Prognostic value of DNA ploidy and proliferating cell nuclear antigen in gastric cancer.
DNA ploidy and the labeling index (LI) of proliferating cell nuclear antigen (PCNA) in gastric cancers were determined using cytofluorometry and immunohistochemistry, respectively, and the prognostic value of these two parameters was evaluated. Of 66 patients with advanced gastric cancers treated with radical resection, 27 with aneuploidy and a high PCNA-LI (> or = 40) showed the lowest 5-year survival rate (38%). Twenty patients with diploid cancers and a high LI showed a lower 5-year survival rate (59%) than the 15 patients with diploid cancers and a low LI (<40), who had the highest 5-year survival rate (86%). A multivariate analysis showed that the grouping based on the ploidy and the LI was an independent prognostic factor. Thus, the combination of DNA ploidy and PCNA-LI may be a useful prognostic indicator for advanced gastric cancers.
Hirose
K
K
First Department of Surgery, Fukui Medical School, Japan.
Iida
A
A
Yamaguchi
A
A
Onchi
H
H
Awata
H
H
Katayama
K
K
Nakagawara
G
G
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004273:DNA, Neoplasm / Q000235:genetics*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011003:Ploidies; D011237:Predictive Value of Tests; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen / Q000097:blood*; D012306:Risk; D013274:Stomach Neoplasms / Q000235:genetics* / Q000276:immunology* / Q000473:pathology / Q000601:surgery; D016019:Survival Analysis
D004273:DNA, Neoplasm; D018809:Proliferating Cell Nuclear Antigen