title: [Clinical characterization of patients with multiple sclerosis defined in Cuba].
abstract: BACKGROUND
  Since 1975 no studies have been done in Cuba defining the clinical characteristics of patients with multiple sclerosis (MS).
  
  
  OBJECTIVE
  To describe the characteristics of a group of Cuban patients with definite clinical MS.
  
  
  METHODS
  Fifty eight patients with definite clinical MS were studied (Poser et al) with normal motor (VCM) and sensory (VCS) conduction velocities. Tests were done on them: clinical scale (Scripps), incapacity (EDSS) and quality of life (Steps), together with various complementary tests. Each patient was classified according to the way in which the disease evolved. Also the two commonest clinical types were compared and we applied the difference test between percentages of non-paired samples with an alfa level of 0.05.
  
  
  RESULTS
  Onset of the illness in most cases was before the age of 40 (86.1%), 75.9% were women and 82.8% were white. In 15.3% there was a family history of MS. In 25.9% there were psychiatric disorders and trigger factors (43.1%. The most frequent initial symptoms were pyramidal (48.3%) sensorial (41.4%) and cerebellar (39.7%). Scripps scale scores were < 80 in 60.2%, in EDSS < 5 (61.9%) and in the Clinical Steps < 3 in 65.4%). Motor potentials (81.9%) somatosensory potential (PESS) (72.3%) and magnetic resonance imaging (MR) (76.4%) were the most abnormal results. Exacerbation-remission (ER) was the most frequent type of evolution (53.4%) generally affecting patients aged under 40 years old (p = 0.02), EDSS < 5 (64.4%), Scripps > 80 (61.2%), Steps < 3 (95.6%), pyramidal system involvement (58.5%), cerebellar (29.2%) and MRI abnormality (80%). The progressive primary form (PP) was the second most frequent (29.3%); 29.4% were under 40 years of age, had more marked changes in all functional system (100%), degree of incapacity and quality of life (100%). PESS (92.5%); the urodynamic tests 58.85%) were less positive on MRI (54.5%) as compared with the ER form.
  
  
  CONCLUSIONS
  The differences found between the clinical forms ER and II indicate that there is greater deterioration in the PP form, probably due to age and more cerebellar and spinal cord involvement.
authors.affiliation: Sección de Esclerosis Multiple, Hospital Gustavo Aldereguía Cienfuegos Cuba cabrera@jagua.sld.cu
authors.forename: J A
authors.initials: JA
authors.lastname: Cabrera-Gómez
authors.forename: E
authors.initials: E
authors.lastname: Santana
authors.forename: O
authors.initials: O
authors.lastname: Vals
authors.forename: M
authors.initials: M
authors.lastname: Casanova
authors.forename: I
authors.initials: I
authors.lastname: Alfaro
authors.forename: A
authors.initials: A
authors.lastname: González-Quevedo
authors.forename: R
authors.initials: R
authors.lastname: Fernández
authors.forename: L
authors.initials: L
authors.lastname: Gómez
authors.forename: M
authors.initials: M
authors.lastname: Báez
authors.forename: A
authors.initials: A
authors.lastname: Rodríguez
authors.forename: L
authors.initials: L
authors.lastname: Quevedo
authors.forename: J A
authors.initials: JA
authors.lastname: Cabrera-Núñez
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D017668:Age of Onset; D002531:Cerebellum / Q000473:pathology*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D003462:Cuba / Q000453:epidemiology; D018450:Disease Progression; D005071:Evoked Potentials; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000453:epidemiology*; D011712:Pyramidal Tracts / Q000473:pathology; D011788:Quality of Life; D017678:Sex Distribution; D013116:Spinal Cord / Q000473:pathology
vernacular_title: Caracterización clínica de pacientes con esclerosis múltiple definida en Cuba.