[In vivo diagnosis of Creutzfeldt-Jakob disease].
The paper presents the data concerning usage of some original method of vital laboratory diagnostics of Creutzfeldt-Jacob disease that belongs to the group of prionic diseases. The method consisted in the inoculation of inoculative culture of rat Gasser ganglion's neurinoma by biologic materials investigated (serum and clot of blood) with the following passivation and investigation of the contaminated culture by means of both morphologic and electron microscopic methods. As an example of vital verificated case the wide pathomorphologic analysis of the biopsy sample of brain was presented. Besides, the efficiency of the investigation of cognitive evoked potentials (P300) together with EEG was also demonstrated as the method of objectification of the development of dementia in this disease.
Zavalishin
I A
IA
Roĭkhel'
V M
VM
Gulevskaia
T S
TS
Gnezditskiĭ
V V
VV
Shitikova
I E
IE
Dzhibladze
D N
DN
Kugoev
A I
AI
Fokona
G I
GI
Kondakova
L M
LM
Sobolev
S G
SG
Pogodina
V V
VV
Chaĭkovskaia
R P
RP
Lozhnikova
S M
SM
Sakharova
A V
AV
Kashina
E M
EM
Sungurov
E B
EB
D001921:Brain / Q000648:ultrastructure*; D007562:Creutzfeldt-Jakob Syndrome / Q000150:complications* / Q000175:diagnosis*; D003704:Dementia / Q000175:diagnosis / Q000209:etiology*; D004569:Electroencephalography; D018913:Event-Related Potentials, P300; D005260:Female; D006801:Humans; D008875:Middle Aged; D009483:Neuropsychological Tests
Prizhiznennaia diagnostika bolezni Kreĭtzfel'dta-Iakoba.