Functional universality and evolutionary diversity: insights from the structure of the ribosome.
The structure of the mammalian ribosome, reconstructed at 25 A resolution, has added a new dimension to our current knowledge, as it manifests the conservation and universality of the ribosome in respect to its primary tasks in protein biosynthesis. A combined approach to study of the ribosome, using X-ray crystallography and electron microscopy, may further improve our understanding of ribosome function in the future.
Yonath
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Max-Planck Unit for Structural Molecular Biology 22603, Hamburg, Germany Department of Structural Biology Weizmann Institute Rehovot, 76100, Israel YONATH@MPGARS.DESY.DE
Franceschi
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F
D000818:Animals; D018360:Crystallography, X-Ray; D019143:Evolution, Molecular; D008322:Mammals; D008854:Microscopy, Electron; D008958:Models, Molecular; D014176:Protein Biosynthesis; D012270:Ribosomes / Q000737:chemistry*