title: Successful treatment of rhinocerebral mucormycosis by a combination of aggressive surgical debridement and the use of systemic liposomal amphotericin B and local therapy with nebulized amphotericin--a case report.
abstract: A case of mucormycosis involving the nose and paranasal sinuses in a 55-year-old man with recently diagnosed acute promyelocytic leukaemia is reported. It was successfully treated with a combination of aggressive surgical debridement and systemic amphotericin B. In addition, local nebulized amphotericin B was used as an adjunct to therapy. We believe this is only the second documented use of nebulized amphotericin in the management of sinonasal mucormycosis. The need for a high index of suspicion and early aggressive management is emphasized.
authors.affiliation: Department of Otolaryngology, Warwick Hospital, UK.
authors.forename: P
authors.initials: P
authors.lastname: Raj
authors.forename: E J
authors.initials: EJ
authors.lastname: Vella
authors.forename: R C
authors.initials: RC
authors.lastname: Bickerton
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D006801:Humans; D008081:Liposomes; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery*; D009330:Nebulizers and Vaporizers; D009668:Nose Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery*; D010254:Paranasal Sinus Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery; D014057:Tomography, X-Ray Computed
chemical_list: D000935:Antifungal Agents; D008081:Liposomes; D000666:Amphotericin B