title: Comparison of low-technology and high-technology monitoring of clomiphene citrate ovulation induction.
abstract: OBJECTIVE
  To determine whether newer monitoring techniques, including urinary detection of the LH surge and vaginal ultrasound, offer an advantage over basal body temperature (BBT) charts alone in achieving pregnancy using clomiphene citrate (CC).
  
  
  METHODS
  Randomized clinical trial.
  
  
  METHODS
  Infertility patients in an academic research environment.
  
  
  METHODS
  Forty-five women undergoing ovulation induction with CC.
  
  
  METHODS
  The women were assigned randomly to receive either low- or high-technology ovulation monitoring for a total of 3 ovulatory cycles. Both groups were followed with BBT charts. The high-technology group also was monitored with urinary LH kits and vaginal ultrasound.
  
  
  METHODS
  Cycle fecundity rates for each technique were compared statistically with use of life-table analysis.
  
  
  RESULTS
  Forty-five patients were studied during a total of 134 cycles. The overall cycle fecundity rate was 8%, 10% (8 of 81 cycles) for the low-technology monitoring group and 6% (3 of 53 cycles) for the high-technology monitoring group. These rates were not statistically significant when evaluated by Fisher's exact test (P = .53) or when using life-table analysis and a log-rank test (P = .48).
  
  
  CONCLUSIONS
  These data suggest that, for initial attempts at ovulation induction with CC in unselected patients, high-technology monitoring of ovulation offers no increase in fecundity over low-technology monitoring.
authors.affiliation: Department of Obstetrics and Gynecology, University of Michigan Medical Center, Ann Arbor 48109-0276, USA. ysmith@umich.edu
authors.forename: Y R
authors.initials: YR
authors.lastname: Smith
authors.forename: J F
authors.initials: JF
authors.lastname: Randolph
authors.forename: G M
authors.initials: GM
authors.lastname: Christman
authors.forename: R
authors.initials: R
authors.lastname: Ansbacher
authors.forename: D M
authors.initials: DM
authors.lastname: Howe
authors.forename: W W
authors.initials: WW
authors.lastname: Hurd
mesh_terms: D000328:Adult; D001831:Body Temperature / Q000502:physiology; D002996:Clomiphene / Q000494:pharmacology*; D005260:Female; D005298:Fertility / Q000187:drug effects; D005300:Fertility Agents, Female / Q000494:pharmacology*; D006801:Humans; D007986:Luteinizing Hormone / Q000652:urine; D010062:Ovulation Induction; D011247:Pregnancy; D013675:Technology, High-Cost; D014463:Ultrasonography; D014621:Vagina / Q000000981:diagnostic imaging
chemical_list: D005300:Fertility Agents, Female; D002996:Clomiphene; D007986:Luteinizing Hormone