Nodular cutaneous microsporidiosis in a patient with AIDS and successful treatment with long-term oral clindamycin therapy.
BACKGROUND
In AIDS, nodular skin disease can result from various causes.


OBJECTIVE
To report a new manifestation of microsporidial infection presenting as nodular skin disease with underlying osteomyelitis.


METHODS
Case report.


METHODS
Tertiary-care military medical center in Washington, D.C.


METHODS
A 36-year-old woman with late-stage AIDS who presented with disseminated, nodular cutaneous lesions and underlying osteomyelitis.


METHODS
Disseminated microsporidial infection with an Encephalitozoon-like species was diagnosed by electron microscopic examination of material obtained from the skin lesions.


METHODS
The patient received long-term oral clindamycin therapy, which cured her disseminated infection.


CONCLUSIONS
Microsporidia can cause disseminated cutaneous infections in AIDS patients. The response of this patient to long-term clindamycin therapy merits further evaluation.
Kester
K E
KE
Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, DC 20307-5100, USA. kesterk@wrsmtp-ccmail.army.mil
Turiansky
G W
GW
McEvoy
P L
PL
D017088:AIDS-Related Opportunistic Infections / Q000150:complications / Q000175:diagnosis*; D000328:Adult; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000977:Antiparasitic Agents; D002981:Clindamycin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D016816:Microsporida / Q000302:isolation & purification*; D010019:Osteomyelitis / Q000150:complications; D012876:Skin Diseases, Parasitic / Q000150:complications / Q000175:diagnosis
D000900:Anti-Bacterial Agents; D000977:Antiparasitic Agents; D002981:Clindamycin