Medicinal foodstuffs. XIV. On the bioactive constituents of moroheiya. (2): New fatty acids, corchorifatty acids A, B, C, D, E, and F, from the leaves of Corchorus olitorius L. (Tiliaceae): structures and inhibitory effect on NO production in mouse peritoneal macrophages.
Following the characterization of the glycosidic constituents in a medical foodstuff "moroheiya," the leaves of Corchorus olitorius L., four higher fatty acids with a trienone function, corchorifatty acids, A, B, C, and D, an undecanoic acid, corchorifatty acid E, and a trihydroxyfatty acid, corchorifatty acid F, were isolated from the less polar fraction of "moroheiya". The structures and optical purity of corchorifatty acids were determined on the basis of chemical and physicochemical evidence. Corchorifatty acids A, B, and C showed an inhibitory effect on lipopolysaccharide-induced NO production in cultured mouse peritoneal macrophages.
Yoshikawa
M
M
Kyoto Pharmaceutical University, Japan.
Murakami
T
T
Shimada
H
H
Yoshizumi
S
S
Saka
M
M
Yamahara
J
J
Matsuda
H
H
D000818:Animals; D002478:Cells, Cultured; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D005227:Fatty Acids / Q000302:isolation & purification* / Q000494:pharmacology; D007564:Japan; D008070:Lipopolysaccharides; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000201:enzymology; D051379:Mice; D009569:Nitric Oxide / Q000032:analysis; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D009573:Nitrites / Q000032:analysis; D018515:Plant Leaves / Q000737:chemistry; D010945:Plants, Edible / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; D005227:Fatty Acids; D008070:Lipopolysaccharides; D009573:Nitrites; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase