Immunolocalization of apolipoprotein D, androgen receptor and prostate specific antigen in early stage prostate cancers.
OBJECTIVE
To determine the cellular distribution and levels of immunohistochemical staining for apolipoprotein D (Apo-D), prostate specific antigen (PSA) and androgen receptor (AR) in early stage prostate cancers.


METHODS
Cellular distribution of Apo-D, PSA and AR in 30 stage A/B prostate cancers and in non-malignant glandular tissue contained in the same sections was detected immunohistochemically, and staining was evaluated by computerized video image analysis.


RESULTS
Staining for Apo-D (percentage positive cellular area) was significantly increased in tumor cells of early stage prostate cancers compared with non-malignant glandular tissue. PSA and AR were present at high levels in both early stage prostate tumors and non-malignant prostate.


CONCLUSIONS
Malignant transformation in the prostate is associated with increased cellular levels of Apo-D.
Zhang
S X
SX
Flinders Cancer Centre, Department of Surgery, Flinders University School of Medicine, Bedford Park, Australia.
Bentel
J M
JM
Ricciardelli
C
C
Horsfall
D J
DJ
Haagensen
D E
DE
Marshall
V R
VR
Tilley
W D
WD
D001053:Apolipoproteins / Q000032:analysis*; D053399:Apolipoproteins D; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009367:Neoplasm Staging; D017430:Prostate-Specific Antigen / Q000032:analysis*; D011471:Prostatic Neoplasms / Q000737:chemistry* / Q000473:pathology; D011944:Receptors, Androgen / Q000032:analysis*
D001053:Apolipoproteins; D053399:Apolipoproteins D; D011944:Receptors, Androgen; D017430:Prostate-Specific Antigen