[Choroid neovascularization in age-related macular degeneration. Correlation of histological and fluorescence angiography findings].
BACKGROUND
Recent studies have raised confusion about the fluorescein angiographical and histopathological correlation of CNV.


METHODS
The preoperative fluorescein angiograms of four patients with subfoveal CNV due to ARMD extracted by pars plana vitrectomy were classified as wellor ill-defined CNV and were correlated to the histopathologically (in serial sections) verrified CNV-location (subneuroretinal (= type II according to Gass) versus sub-RPE (type I according to Gass)).


RESULTS
The locations of all four CNV could be classified by histopathological landmarks as there were RPE, BLD/drusen, and inner Bruchs membrane. Angiographically welldefined membranes were type II membranes according to Gass, whereas the ill-defined membrane represented type I. The CNV with well- and ill-defined borders consisted of type II and type I parts according to Gass.


CONCLUSIONS
We find subneuroretinal locations of the well-defined CNV examined (type II membranes according to Gass). Correspondingly, ill-defined CNV or ill-defined parts of a CNV seem to be beneath the RPE (type I). The correlation of fluorescein angiography and histopathology should be studied in greater numbers of well- and ill-defined CNV.
Hoops
J P
JP
Augenklinik der Ludwig-Maximilians-Universität München.
Scheider
A
A
Messmer
E M
EM
Grasbon
T
T
Gündisch
O
O
Kampik
A
A
D016570:Bruch Membrane / Q000473:pathology; D002829:Choroid / Q000098:blood supply*; D005451:Fluorescein Angiography; D006801:Humans; D008268:Macular Degeneration / Q000175:diagnosis* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000175:diagnosis* / Q000473:pathology; D010857:Pigment Epithelium of Eye / Q000473:pathology; D015593:Retinal Drusen / Q000473:pathology; D012166:Retinal Hemorrhage / Q000175:diagnosis / Q000473:pathology
Chorioidale Neovaskularisationen bei AMD. Korrelation histologischer und fluoreszenzangiographischer Befunde.