A method for the confirmation and identification of drugs of misuse in urine using solid phase extraction and gas-liquid chromatography with mass spectrometry.
A method is described for the confirmation/identification of a range of commonly misused drugs in urine samples. The method has been used for two years without problems for a range of purposes including hospital/clinic drugs of misuse screening and for toxicology in coroner's cases. Urine samples which have given a positive result on immunochemical screening for a particular drug group or groups (for example, opiates) can be processed with identification of the drugs present using a single procedure. Bond ElutCertify columns are used for the extraction of drugs from the samples followed by propionylation and gas chromatography with mass selective detection.
Galloway
J H
JH
Department of Clinical Chemistry, Royal Hallamshire Hospital, Sheffield, UK.
Ashford
M
M
Marsh
I D
ID
Holden
M
M
Forrest
A R
AR
D003061:Codeine / Q000652:urine; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D013287:Illicit Drugs / Q000652:urine*; D008691:Methadone / Q000652:urine; D009020:Morphine / Q000652:urine; D009022:Morphine Derivatives / Q000652:urine; D012680:Sensitivity and Specificity; D015813:Substance Abuse Detection / Q000379:methods*
D013287:Illicit Drugs; D009022:Morphine Derivatives; D009020:Morphine; C026979:6-O-monoacetylmorphine; D008691:Methadone; D003061:Codeine