title: [Influences of trabeculectomy combined with the use of mitomycin C on corneal endothelial cells].
abstract: We used a specular microscope to evaluate the corneal endothelial cells in 119 eyes before and 2 to 3 weeks after trabeculectomy with topical mitomycin C. The endothelial cell density per square millimeter averaged 2,569 +/- 487 (mean +/- standard deviation) before surgery and 2,444 +/- 536 after surgery, showing a decrease of 4.98%. The hexagonality decreased by 1.7%, the coefficient of variation increased by 1.9, and the average cell area increased by 6.82%. There were no statistical differences as a whole in these values. Decrease in hexagonality was more frequent in eyes with prior intraocular or glaucoma surgery. Eyes treated by laser trabeculoplasty showed a decrease in endothelial cell density, an increase in coefficient of variation and an increase in hexagonality. Eyes with postoperative flat anterior chamber showed significant changes in each parameter. The findings show that trabeculectomy with topical mitomycin C does not significantly affect the corneal endothelial cells at 2 to 3 weeks after surgery.
authors.affiliation: Department of Ophthalmology, Niigata University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sano
authors.forename: T
authors.initials: T
authors.lastname: Fukuchi
authors.forename: S
authors.initials: S
authors.lastname: Sawaguchi
authors.forename: H
authors.initials: H
authors.lastname: Hara
authors.forename: J
authors.initials: J
authors.lastname: Watanabe
authors.forename: A
authors.initials: A
authors.lastname: Oota
authors.forename: M
authors.initials: M
authors.lastname: Shirakashi
authors.forename: H
authors.initials: H
authors.lastname: Abe
mesh_terms: D000287:Administration, Topical; D004728:Endothelium, Corneal / Q000166:cytology* / Q000187:drug effects; D005260:Female; D005901:Glaucoma / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage / Q000494:pharmacology*; D014130:Trabeculectomy
chemical_list: D016685:Mitomycin