title: Oral pharmacological treatments for parasitic diseases of rainbow trout Oncorhynchus mykiss. I: Hexamita salmonis.
abstract: Various drugs were evaluated as regards efficacy for the treatment of Hexamita salmonis infection in rainbow trout. The results confirm the efficacy of nitroimidazoles: infection was completely eradicated not only by metronidazole (which has been recommended previously for the treatment of hexamitosis), but also by benznidazole, ronidazole and secnidazole, which have not been assayed previously. The non-nitroimidazoles albendazole, aminosidine, diethylcarbamazine and nitroscanate also completely eliminated infection. The remaining non-nitroimidazoles tested (amprolium, bithionol, febantel, flubendazole, levamisole, netobimin, niclosamide, nitroxynil, oxibendazole, parbendazole, piperazine, praziquentel, tetramisole, thiophanate, toltrazuril, trichlorfon and triclabendazole) were not effective.
authors.affiliation: Department of Microbiology and Parasitology, Faculty of Pharmacy, Universidad de Santiago de Compostela, Spain. mpmatesa@usc.es
authors.forename: J L
authors.initials: JL
authors.lastname: Tojo
authors.forename: M T
authors.initials: MT
authors.lastname: Santamarina
mesh_terms: D000284:Administration, Oral; D015766:Albendazole / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004049:Diethylcarbamazine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D016828:Diplomonadida / Q000187:drug effects*; D005243:Feces / Q000469:parasitology; D005393:Fish Diseases / Q000188:drug therapy* / Q000469:parasitology; D009593:Nitroimidazoles / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D017686:Oncorhynchus mykiss / Q000469:parasitology*; D010303:Paromomycin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D010647:Phenyl Ethers / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D011529:Protozoan Infections, Animal / Q000188:drug therapy* / Q000469:parasitology; D013861:Thiocyanates / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000981:Antiprotozoal Agents; D009593:Nitroimidazoles; D010647:Phenyl Ethers; D013861:Thiocyanates; D010303:Paromomycin; D015766:Albendazole; C011042:nitroscanate; D004049:Diethylcarbamazine