Resolution of xanthomas in Alagille syndrome after liver transplantation.
Alagille syndrome (arteriohepatic dysplasia) is a genetic disorder with autosomal dominant transmission which has been localized to chromosome 20p. Cutaneous manifestations include jaundice, pruritus, and widespread xanthomata. We report a child with severe Alagille syndrome in whom orthotopic liver transplantation caused rapid resolution of disfiguring xanthomas.
Buckley
D A
DA
Department of Dermatology, King's College Hospital, Denmark Hill, London, England.
Higgins
E M
EM
du Vivier
A W
AW
D016738:Alagille Syndrome / Q000150:complications* / Q000601:surgery*; D002648:Child; D005500:Follow-Up Studies; D006229:Hand Dermatoses / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D014973:Xanthomatosis / Q000209:etiology* / Q000503:physiopathology