title: Intraventricular streptokinase infusion in acute post-haemorrhagic hydrocephalus.
abstract: Neonatal post-haemorrhagic hydrocephalus is a clinical condition with a high mortality and long-term morbidity. Its clinical management is difficult and not well standardized. We describe the case of a term baby suffering from acute intracranial hypertension caused by an intraventricular and thalamic haemorrhage. In this case, the external ventricular drain inserted to control intracranial pressure was ineffective because of repeated obstructions due to blood clots. Continuous intraventricular infusion of streptokinase of 20,000 U/day allowed quick lysis of the clots, drainage of the cerebrospinal fluid and relief from the coma. Although it did not prevent a permanent ventriculoperitoneal shunt, we obtained reabsorption of the intraventricular haemorrhage without rebleeding complications. We suggest the use of low-dose fibrinolytic infusion through an external drain for the treatment of acute intracranial hypertension following intraventricular haemorrhage in term infants.
authors.affiliation: Institute of Pediatrics, Catholic University of Rome, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Luciano
authors.forename: L
authors.initials: L
authors.lastname: Tortorolo
authors.forename: A
authors.initials: A
authors.lastname: Chiaretti
authors.forename: M
authors.initials: M
authors.lastname: Piastra
authors.forename: F
authors.initials: F
authors.lastname: Velardi
authors.forename: G
authors.initials: G
authors.lastname: Polidori
mesh_terms: D000208:Acute Disease; D002543:Cerebral Hemorrhage / Q000134:cerebrospinal fluid / Q000150:complications / Q000188:drug therapy*; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006801:Humans; D006849:Hydrocephalus / Q000134:cerebrospinal fluid / Q000188:drug therapy* / Q000209:etiology; D007231:Infant, Newborn; D007263:Infusions, Parenteral; D007276:Injections, Intraventricular; D019586:Intracranial Hypertension / Q000134:cerebrospinal fluid / Q000150:complications / Q000188:drug therapy; D013300:Streptokinase / Q000008:administration & dosage*
chemical_list: D005343:Fibrinolytic Agents; D013300:Streptokinase