Physiological role of L-ascorbic acid in rats exposed x887p6arette smoke.
This study clarifies the effect of exposure to cigarette smoke on L-ascorbic acid (AsA) metabolism and on the activities of drug-metabolizing enzymes. Male Wistar rats were used. The test rats (group T) were exposed to side-stream smoke from cigarette for 2 h every day for 25 days. During the experimental period, the excreted amount of AsA in the urine from group T was higher than that from the control group (group C). At the end of the experimental period, the AsA content of the plasma and tissues, the liver cytochrome P-450 content and the activities of drug-metabolizing enzymes in group T were each higher than those in group C.
Kurata
T
T
Institute of Environmental Science for Human Life, Ochanomizu University, Tokyo, Japan.
Suzuki
E
E
Hayashi
M
M
Kaminao
M
M
D000818:Animals; D001205:Ascorbic Acid / Q000097:blood / Q000378:metabolism* / Q000652:urine; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D008099:Liver / Q000201:enzymology; D008297:Male; D010947:Plants, Toxic; D051381:Rats; D017208:Rats, Wistar; D012906:Smoke / Q000009:adverse effects*; D014026:Nicotiana
D012906:Smoke; D003577:Cytochrome P-450 Enzyme System; D001205:Ascorbic Acid