The use of tretinoin as oral mucositis prophylaxis in bone marrow transplantation patients: a preliminary study.
OBJECTIVE
The examination of prophylactic efficacy of tretinoin on oral mucositis, post bone marrow transplantation (BMT).


METHODS
The study population consisted of 11 patients undergoing BMT. Six tretinoin topically-treated patients (0.25 mg daily of 0.1% tretinoin cream) were matched with five non-treated control patients comparing mucositis severity, duration and analgetic (morphine) requirements. Concomitant follow-up included conditioning parameters associated with mucositis and engraftment.


RESULTS
The mean of oral mucositis peak scores was significantly lower in the tretinoin-treated patients vs the non-treated patients (score 1.5 vs 3.6; P < 0.02). In the majority of cases the duration of the most severe phase of oral mucositis was shorter in the tretinoin-treated group as compared with the control. Only one patient in the experimental group required morphine analgesics compared with four patients in the control group.


CONCLUSIONS
This preliminary study indicates that the severity of oral mucositis, both objective and subjective, in BMT patients may be reduced by 0.1% topical tretinoin cream, 0.25 mg, administered daily from the beginning of the BMT conditioning regimen until marrow engraftment.
Cohen
G
G
Hospital Oral Medicine Department, Hadassah, Hebrew University, School of Dental Medicine, Jerusalem, Israel.
Elad
S
S
Or
R
R
Galili
D
D
Garfunkel
A A
AA
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D002648:Child; D017742:Dental Care for Chronically Ill / Q000379:methods*; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa; D010865:Pilot Projects; D013280:Stomatitis / Q000209:etiology / Q000517:prevention & control*; D014212:Tretinoin / Q000008:administration & dosage / Q000627:therapeutic use*
D014212:Tretinoin