title: Lactic dehydrogenase virus infection enhances parasite egg production and inhibits eosinophil and mast cell responses in mice infected with the nematode Nippostrongylus brasiliensis.
abstract: The effects of lactic dehydrogenase virus (LDV) infection on the protective immune responses to the nematode Nippostrongylus brasiliensis were studied. Mice with chronic LDV infection showed significantly higher levels of parasite egg production than non-LDV-infected (control) mice after N. brasiliensis infection. Concurrent LDV infection also suppressed peripheral blood eosinophilia and the lung mastocytosis induced by this nematode. LDV infection showed higher expression levels of the interferon-gamma (IFN-gamma) mRNA in lymph nodes compared with control mice before N. brasiliensis infection. In addition, the IgG2a production in LDV-infected mice was higher than that in control mice before and after N. brasiliensis infection. These results suggest that LDV infection modulates protective immune responses against N. brasiliensis infection by the activation of T-helper type 1 cells.
authors.affiliation: Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Morimoto
authors.forename: M
authors.initials: M
authors.lastname: Yamada
authors.forename: N
authors.initials: N
authors.lastname: Arizono
authors.forename: T
authors.initials: T
authors.lastname: Hayashi
mesh_terms: D000818:Animals; D018174:Arterivirus Infections / Q000276:immunology* / Q000469:parasitology; D002908:Chronic Disease; D004804:Eosinophils / Q000276:immunology; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007371:Interferon-gamma / Q000096:biosynthesis; D007583:Jejunum / Q000276:immunology; D007772:Lactate dehydrogenase-elevating virus; D007958:Leukocyte Count; D008168:Lung / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology; D008297:Male; D008407:Mast Cells / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D009559:Nippostrongylus; D010270:Parasite Egg Count; D012333:RNA, Messenger / Q000378:metabolism; D017206:Strongylida Infections / Q000276:immunology* / Q000469:parasitology
chemical_list: D007074:Immunoglobulin G; D012333:RNA, Messenger; D007073:Immunoglobulin E; D007371:Interferon-gamma