HMGI family proteins: architectural transcription factors in mammalian development and cancer.
The HMGI proteins, a subfamily of the high mobility group (HMG) proteins, play an important role in the regulation of gene expression. They bind to AT-rich DNA sequences and alter DNA conformation to modulate the binding affinity of transcription factors to their cognate sites. They are expressed almost exclusively during embryogenesis and Hmgi-c null mice have the mouse pygmy phenotype. Studies have revealed the disruption of HMGI family genes in a variety of mesenchymal-derived benign tumors. Therefore, the HMGI genes function in the coordination of cell proliferation and differentiation during mammalian development.
Zhou
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Department of Biochemistry, UMDNJ-Robert Wood Johnson Medical School 08854-5635, USA.
Chada
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D000595:Amino Acid Sequence; D000818:Animals; D005314:Embryonic and Fetal Development / Q000502:physiology; D006609:High Mobility Group Proteins / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family; D009369:Neoplasms / Q000503:physiopathology*; D014157:Transcription Factors / Q000502:physiology*
D006609:High Mobility Group Proteins; D014157:Transcription Factors