title: [Liver changes in AIDS. Retrospective analysis of 227 autopsies of HIV-positive patients].
abstract: In a retrospective study of a 12-year period (1981-1992) liver histology was analyzed in 227 autopsied patients infected with the human immunodeficiency virus. Normal histology could only be documented in 29 patients (13%). In the majority of cases (56%) uncharacteristic changes were seen such as steatosis (34%), hemosiderosis (10%) or non-specific reactive hepatitis (7%). The finding of hepatic peliosis obtained in 4 patients was not associated with inflammatory liver changes, especially infections from Rochalimaea. Within a wide range of opportunistic infections recorded in 50 patients (22%), hepatitis caused by Cytomegalovirus (8%), Toxoplasma gondii (5%), Leishmania donovani (1%), Cryptococcus neoformans and Pneumocystis carinii (each 0.5%) was diagnosed. Among 16 cases (7%) of mycobacterial liver infections typical mycobacteria were found in two patients and atypical mycobacteria in 14 patients, respectively. In 23 patients (10%) chronic viral hepatitis, caused by HBV (7%) or HCV infections (3%), respectively, was observed. Hepatitis was typed as mild only in each 5 patients with HBV or HCV infection, whereas the remaining cases showed a transition towards cirrhosis. Two patients with HBV-associated cirrhosis developed hepatocellular carcinoma. The remaining 32 malignant liver tumors represented secondary neoplasms, including 13 cases of non-Hodgkin's lymphomas.
authors.affiliation: Departement für Innere Medizin, Universitätsspital Zürich.
authors.forename: A
authors.initials: A
authors.lastname: Trojan
authors.forename: K A
authors.initials: KA
authors.lastname: Kreuzer
authors.forename: R
authors.initials: R
authors.lastname: Flury
authors.forename: M
authors.initials: M
authors.lastname: Schmid
authors.forename: J
authors.initials: J
authors.lastname: Schneider
authors.forename: S
authors.initials: S
authors.lastname: Schröder
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000473:pathology*; D000163:Acquired Immunodeficiency Syndrome / Q000473:pathology*; D006679:HIV Seropositivity / Q000473:pathology*; D006801:Humans; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000473:pathology*; D008113:Liver Neoplasms / Q000473:pathology; D012189:Retrospective Studies
vernacular_title: Leberveränderungen bei AIDS. Retrospektive Analyse von 227 Sektionen HIV-positiver Patienten.