Dehydroradiosumin, a trypsin inhibitor from the cyanobacterium Anabaena cylindrica.
Dehydroradiosumin, a novel potent trypsin inhibitory dipeptide, was isolated from the freshwater cyanobacterium Anabaena cylindrica (NIES-19). Its structure was elucidated as 1 on the basis of 2D NMR data and chemical degradation. The IC50 of 1 against trypsin was 0.1 microg/mL.
Kodani
S
S
Laboratory of Marine Biochemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113, Japan.
Ishida
K
K
Murakami
M
M
D017033:Anabaena / Q000737:chemistry*; D002240:Carbohydrate Sequence; D004151:Dipeptides / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008969:Molecular Sequence Data; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014361:Trypsin Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology
D004151:Dipeptides; D014361:Trypsin Inhibitors; C113242:dehydroradiosumin