[Chlormadinone Acetate Reference Standard (Control 961) of National Institute of Health Sciences].
The raw material for chlormadinone acetate was tested for preparation of the "Chlormadinone Acetate Reference Standard (Control 961)" of National Institute of Health Sciences. Analytical data obtained were as follows: melting point, 215. 3 degrees C; UV spectrum, lambda max = 283.5 nm; IR spectrum, the same as that of JP Chlormadinone Acetate Reference Standard (Control 885); optical rotation, [alpha]20D = -13.0 degrees; thin-layer chromatography, one impurity was detected; high-performance liquid chromatography, two impurities were detected; loss on drying, 0.01%; assay, 99.4% by spectrophotometry and 99.5% by HPLC. Based on the above results, the raw material was authorized as the Chlormadinone Acetate Reference Standard (Control 961) of National Institute of Health Sciences (Japanese Pharmacopoeia).
Kitajima
A
A
Tagashira
Y
Y
Maekawa
K
K
Yoshii
K
K
Komatsu
H
H
Tanimoto
T
T
Okada
S
S
D002715:Chlormadinone Acetate / Q000592:standards*; D007564:Japan; D012015:Reference Standards
D002715:Chlormadinone Acetate