New pyrrole alkaloids from Solanum sodomaeum.
Two new pyrrole alkaloids, solsodomine A and B, were isolated from the fresh berries of Solanum sodomaeum L., collected from the Libyan desert. The structures of these compounds were established by 2D-NMR, including 15N NMR spectroscopy and chemical degradation. Solsodomine A (1) shows activity against Mycobacterium intracellulare. This is the first report of pyrrole alkaloids from the genus Solanum.
El Sayed
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KA
The Department of Pharmacognosy and National Center for the Development of Natural Products and Research Institute of Pharmaceutical Sciences, University of Mississippi, University, Mississippi 38677, USA. elsayed@olemiss.edu
Hamann
M T
MT
Abd El-Rahman
H A
HA
Zaghloul
A M
AM
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002240:Carbohydrate Sequence; D008002:Libya; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009161:Mycobacterium / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry*; D012991:Solanaceous Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000900:Anti-Bacterial Agents; D012991:Solanaceous Alkaloids; C113238:solsodomine A; C113239:solsodomine B