Antiallergic/antiasthmatic activity of oligopeptide related to IgE.
In spite of continuous research in the field of bronchial asthma, still no satisfactory drug is available. Recently a new class of oligopeptide exhibited antiallergic activity by inhibiting the synthesis of IgE antibody. The analogue of ADSDGK (94-335) has shown antiallergic activity in experimental models. The 94-335 inhibited the passive cutaneous anaphylaxis (PCA) reactions in rats in a dose-dependent manner (0.5-10 mg kg-1 p.o.) by 47-90%. There was a 70-87% protection of mast cell degranulation induced by compound 48/80 with peptide 94-335 at 0.5-1.5 mg kg-1 p.o. in rats. This peptide also inhibited antigen- induced contraction in sensitised guinea pig ileum. There was 18 and 72% protection to bronchoconstriction induced by histamine and egg albumin, respectively, in an aerosol test in guinea pigs. These effects of compound 94-335 were comparable with that of the clinically-used antiallergic drug disodium cromoglycate (DSCG). The results suggest that peptide 94-335 possesses potent antiallergic activity.
Singh
R
R
Division of Pharmacology, Central Drug Research Institute, Lucknow, 226001, India.
Nath
A
A
Gupta
P P
PP
Shulka
M
M
Khare
S K
SK
Kundu
B
B
D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D018927:Anti-Asthmatic Agents / Q000494:pharmacology*; D006168:Guinea Pigs; D007073:Immunoglobulin E / Q000096:biosynthesis*; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley
D018926:Anti-Allergic Agents; D018927:Anti-Asthmatic Agents; D009842:Oligopeptides; D007073:Immunoglobulin E