title: [Potentiometric electrodes for determining choline, butyrylcholine and cholinesterase inhibitors].
abstract: Potentiometric choline electrodes were developed on the basis of the mediator-free bioelectrocatalysis. The electrodes made of a composite carbon-polymer material contain choline oxidase and peroxidase coimmobilized on the surface of the electrode. The rate of the potential increase was shown to be proportional to the choline concentration within a broad range of variation. Coupling of choline-sensitive electrodes with butyrylcholinesterase makes possible both the direct detection of butyrylcholine and analysis of butyrylcholinesterase inhibitors.
authors.affiliation: All-Russia Research Center for Molecular Diagnosis and Treatment, Moscow, Russia.
authors.forename: A L
authors.initials: AL
authors.lastname: Gindilis
authors.forename: I N
authors.initials: IN
authors.lastname: Kurochkin
mesh_terms: D002091:Butyrylcholinesterase / Q000187:drug effects; D002384:Catalysis; D002794:Choline / Q000031:analogs & derivatives* / Q000032:analysis*; D002800:Cholinesterase Inhibitors / Q000032:analysis*; D004566:Electrodes; D007700:Kinetics; D011199:Potentiometry / Q000295:instrumentation*
chemical_list: D002800:Cholinesterase Inhibitors; C017100:butyrylcholine; D002091:Butyrylcholinesterase; D002794:Choline
vernacular_title: Potentsiometricheskie élektrody dlia opredeleniia kholina, butirilkholina i ingibitorov kholinésteraz.