Biocompatibility of Clearfil Liner Bond 2 and Clearfil AP-X system on nonexposed and exposed primate teeth.
OBJECTIVE
Recent studies have demonstrated that acid etching of vital dentin and pulpal tissue does not retard pulpal healing, odontoblastoid cell differentiation, or dentinal bridge formation when the pulp is capped with adhesive resins. The purpose of this study was to evaluate the pulpal response in nonexposed and exposed monkey pulps to treatment with the Clearfil Liner Bond 2 and Clearfil AP-X system.


METHODS
Class V and Class I cavities in nonexposed and exposed pulps were observed at 7 or 8, 27, and 97 days.


RESULTS
There were no differences in pulpal inflammation between the Clearfil Liner Bond 2/Clearfil AP-X specimens and calcium hydroxide controls in either Class V or Class I cavities at the various time periods.


CONCLUSIONS
Clearfil Liner Bond 2 and Clearfil AP-X system is not toxic to either nonexposed or exposed pulpal tissues when placed according to manufacturer's directions.
Akimoto
N
N
University of Alabama at Birmingham, School of Dentistry 35294-0007, USA.
Momoi
Y
Y
Kohno
A
A
Suzuki
S
S
Otsuki
M
M
Suzuki
S
S
Cox
C F
CF
D000818:Animals; D001672:Biocompatible Materials / Q000633:toxicity*; D003736:Dental Cavity Lining; D003782:Dental Pulp / Q000187:drug effects* / Q000382:microbiology; D003785:Dental Pulp Capping / Q000009:adverse effects / Q000379:methods*; D003790:Dental Pulp Necrosis / Q000139:chemically induced; D003809:Dentin, Secondary; D008253:Macaca mulatta; D008689:Methacrylates / Q000633:toxicity*; D009804:Odontoblasts / Q000187:drug effects; D011671:Pulpitis / Q000139:chemically induced; D012973:Sodium Hypochlorite / Q000494:pharmacology; D014945:Wound Healing
D001672:Biocompatible Materials; C112828:Clearfil AP-X; C112274:Clearfil Liner Bond 2; D008689:Methacrylates; D012973:Sodium Hypochlorite