Micronization: a method of improving the bioavailability of poorly soluble drugs.
For poorly soluble drugs, the digestive absorption depends on their rate of dissolution. Decreasing the particle size of these drugs improves their rate of dissolution. Fine grinding mills are use to micronize powders: either jar mills or fluid energy mills. Theses processes were applied to griseofulvin, progesterone, spironolactone and diosmin. For each drug, micronization improved their digestive absorption, and consequently their bioavailability and clinical efficacy.
Chaumeil
J C
JC
Laboratoire de Pharmacotechnie et Dermopharmacie, Faculté des Sciences Pharmaceutiques et Biologiques, Université René-Descartes, Paris, France.
D001682:Biological Availability; D004145:Diosmin / Q000493:pharmacokinetics*; D004339:Drug Compounding; D006118:Griseofulvin / Q000493:pharmacokinetics*; D010316:Particle Size; D011374:Progesterone / Q000493:pharmacokinetics*; D012995:Solubility; D013148:Spironolactone / Q000493:pharmacokinetics*
D013148:Spironolactone; D006118:Griseofulvin; D011374:Progesterone; D004145:Diosmin