Molecular recapitulation: the growth of the vertebrate retina.
In postembryonic lower vertebrates, the ciliary marginal zone (CMZ) of the retina is a continuously growing zone in the central nervous system. By studying the cellular and molecular biology of the cells in this region, we have discovered that the CMZ can be divided into several zones, from peripheral to central, which reflect different stages of development of retinal stem cells. Based on the behavior of the cells and on the genes expressed in different regions, we propose here that cellular development in the CMZ recapitulates in space what happens in embryonic retinal development in time.
Harris
W A
WA
Department of Anatomy, University of Cambridge, United Kingdom. harris@mole.bio.cam.ac.uk
Perron
M
M
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D008954:Models, Biological; D012160:Retina / Q000166:cytology / Q000254:growth & development*; D013234:Stem Cells / Q000502:physiology