title: Acute liver failure caused by isoniazid in a child receiving carbamazepine.
abstract: We report a case of a 10-year-old boy, being treated for seizures with carbamazepine, who developed acute liver failure within four days of initiation of therapy for suspected tuberculosis with isoniazid, rifampin, pyrazinamide, and ethambutol. Isoniazid-induced liver disease was diagnosed. The likely role of carbamazepine and rifampin in potentiating the hepatotoxicity of isoniazid, and the importance of early recognition of isoniazid-induced liver disease, are discussed.
authors.affiliation: Department of Pediatrics, Emory University School of Medicine, and Pharmacy, Egleston Children's Hospital, Atlanta, Georgia 30303, USA.
authors.forename: F E
authors.initials: FE
authors.lastname: Berkowitz
authors.forename: S L
authors.initials: SL
authors.lastname: Henderson
authors.forename: N
authors.initials: N
authors.lastname: Fajman
authors.forename: B
authors.initials: B
authors.lastname: Schoen
authors.forename: M
authors.initials: M
authors.lastname: Naughton
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects*; D000995:Antitubercular Agents / Q000009:adverse effects*; D002220:Carbamazepine / Q000009:adverse effects*; D002648:Child; D004347:Drug Interactions; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects*; D017114:Liver Failure, Acute / Q000139:chemically induced*; D008297:Male
chemical_list: D000927:Anticonvulsants; D000995:Antitubercular Agents; D002220:Carbamazepine; D007538:Isoniazid