Predictive sensitivity of human cancer cells in vivo using semipermeable polysulfone fibers.
An in vivo experimental model was developed to predict efficiently and accurately chemosensitivity of human tumors. Human cancer cells either from cultured cell lines or from patients' tumors were injected directly into semipermeable polysulfone fibers subsequently implanted into immunocompetent rats. Results suggest utility of this novel model system for predicting tumor sensitivity to a wide range of anticancer agents and for potentially guiding the treatment of cancer patients in the clinical setting.
Chu
M Y
MY
Department of Medicine and Clinical Pharmacology, Brown University and Rhode Island Hospital, Providence 02903, USA.
Lipsky
M H
MH
Yee
L K
LK
Epstein
J
J
Whartenby
K A
KA
Freeman
S
S
Chen
T M
TM
Chu
E
E
Forman
E N
EN
Calabresi
P
P
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use; D001672:Biocompatible Materials; D002292:Carcinoma, Renal Cell / Q000188:drug therapy / Q000473:pathology; D005057:Eukaryotic Cells / Q000187:drug effects / Q000378:metabolism / Q000821:virology; D005260:Female; D015774:Ganciclovir / Q000494:pharmacology / Q000627:therapeutic use; D005814:Genes, Viral / Q000235:genetics; D006801:Humans; D008567:Membranes, Artificial; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000235:genetics; D011108:Polymers; D011237:Predictive Value of Tests; D011379:Prognosis; D051381:Rats; D017207:Rats, Sprague-Dawley; D012680:Sensitivity and Specificity; D018139:Simplexvirus / Q000201:enzymology / Q000235:genetics; D013450:Sulfones; D013937:Thymidine Kinase / Q000235:genetics; D014162:Transfection; D014407:Tumor Cells, Cultured / Q000166:cytology / Q000187:drug effects / Q000637:transplantation
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D001672:Biocompatible Materials; D008567:Membranes, Artificial; D011108:Polymers; D013450:Sulfones; D013937:Thymidine Kinase; D015774:Ganciclovir