title: Cytogenetics of a malignant ovarian germ-cell tumor.
abstract: Cytogenetic investigation of a malignant ovarian tumor diagnosed as a mixed germ-cell tumor, composed of extensive choriocarcinoma and foci of yolk-sac tumor, revealed a highly abnormal chromosomal pattern. We found a chromosome number in the hypertriploid/hypotetraploid range, and several clonal structural abnormalities, including 2 copies of an isochromosome 12p. We showed that the chromosomal pattern of this ovarian tumor is very similar to that of testicular germ-cell tumors. This finding, together with reported cytogenetic data of malignant ovarian germ-cell tumors, supports the hypothesis that ovarian and testicular germ-cell tumors are strongly related entities that may have a similar origin and pathogenetic pathway.
authors.affiliation: Department of Medical Genetics, University of Groningen, The Netherlands. J.van.Echten-Arends@Med.Rug.nl
authors.forename: J
authors.initials: J
authors.lastname: van Echten
authors.forename: L C
authors.initials: LC
authors.lastname: van Doorn
authors.forename: H C
authors.initials: HC
authors.lastname: van der Linden
authors.forename: A Y
authors.initials: AY
authors.lastname: van der Veen
authors.forename: C W
authors.initials: CW
authors.lastname: Burger
authors.forename: B
authors.initials: B
authors.lastname: de Jong
mesh_terms: D000328:Adult; D000782:Aneuploidy; D002869:Chromosome Aberrations; D002881:Chromosomes, Human, Pair 12; D005260:Female; D018237:Germinoma / Q000235:genetics*; D006801:Humans; D018404:Isochromosomes; D007621:Karyotyping; D010051:Ovarian Neoplasms / Q000235:genetics*