1-[2(R)-(2-amino-2-methylpropionylamino)-3-(1H-indol-3-yl)propionyl]- 3-benzylpiperidine-3(S)-carboxylic acid ethyl ester (L-163,540): a potent, orally bioavailable, and short-duration growth hormone secretagogue.
Yang
L
L
Merck Research Laboratories, Rahway, New Jersey 07065, USA.
Morriello
G
G
Patchett
A A
AA
Leung
K
K
Jacks
T
T
Cheng
K
K
Schleim
K D
KD
Feeney
W
W
Chan
W W
WW
Chiu
S H
SH
Smith
R G
RG
D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D018360:Crystallography, X-Ray; D004285:Dogs; D004952:Esters / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D010880:Piperidines / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D010902:Pituitary Gland / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013237:Stereoisomerism
D004952:Esters; C113159:L 163540; D010880:Piperidines; D013006:Growth Hormone