title: Does disparate occurrence of autoregulatory programmed frameshifting in decoding the release factor 2 gene reflect an ancient origin with loss in independent lineages?
abstract: In Escherichia coli an autoregulatory mechanism of programmed ribosomal frameshifting governs the level of polypeptide chain release factor 2. From an analysis of 20 sequences of genes encoding release factor 2, we infer that this frameshift mechanism was present in a common ancestor of a large group of bacteria and has subsequently been lost in three independent lineages.
authors.affiliation: Howard Hughes Medical Institute, University of Utah, Salt Lake City 84112-5330, USA.
authors.forename: B C
authors.initials: BC
authors.lastname: Persson
authors.forename: J F
authors.initials: JF
authors.lastname: Atkins
mesh_terms: D000595:Amino Acid Sequence; D001419:Bacteria / Q000145:classification / Q000235:genetics*; D001483:Base Sequence; D017124:Conserved Sequence; D019143:Evolution, Molecular; D016368:Frameshift Mutation; D006706:Homeostasis; D008969:Molecular Sequence Data; D010454:Peptide Termination Factors / Q000737:chemistry / Q000235:genetics*; D010802:Phylogeny; D012270:Ribosomes / Q000378:metabolism; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid
chemical_list: D010454:Peptide Termination Factors; C041460:peptide chain termination release factor 2