[Effect of levamisole on microbicidal activity and chemotaxis in polymorphonuclear cells].
OBJECTIVE
Neonatal septicemia may have a mortality of 20% in newborns small for their-gestational age. This susceptibility for infections has been explained by immunological disorders. The aim of this study to know the effect of levamisole on the functions of chemotaxis and bacterial activity of PMN cells in newborns small for their-gestational age.


METHODS
Twenty full-term newborns were studied. Ten of them were small for their-gestational age, and the other 10 had body weight within the normal range. Microbicidal activity and chemotaxis were measured, and comparisons between groups were made with non-parametric statistical tests.


RESULTS
In the group of newborns small for their-gestational age. Microbicidal activity was similar to control group, but chemotactic activity was reduced (p < 0.05).
Dávila Velázquez
J R
JR
Departamento de Inmunología Clínica y Alergia, Hospital de Especialidades CMN Siglo XXI, IMSS, México, DF.
Santos Preciado
J I
JI
Martínez Cairo
S
S
D001770:Blood Bactericidal Activity; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000276:immunology*; D007978:Levamisole / Q000494:pharmacology*; D008297:Male; D009504:Neutrophils / Q000187:drug effects* / Q000502:physiology*
D007978:Levamisole
Efecto del levamisol en la actividad microbicida y quimiotaxis en células polimorfonucleares.