title: Alpha-fetoprotein producing pulmonary blastoma in a patient with systemic sclerosis: pathogenetic analysis.
abstract: We describe a rare case of pulmonary blastoma complicated with systemic sclerosis. The serum alpha-fetoprotein level was elevated at presentation and the biopsied tumour stained positively against anti-alpha-fetoprotein antibody. The alpha-fetoprotein produced autonomously by tumour cells was of yolk-sac origin. Although the pathogenesis of pulmonary blastoma has not been clarified, we suggest that this pulmonary blastoma is a type of yolk-sac tumour.
authors.affiliation: First Dept of Internal Medicine, Tokyo Medical College Hospital, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Kasuga
authors.forename: D
authors.initials: D
authors.lastname: Miyamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Ichinose
authors.forename: W
authors.initials: W
authors.lastname: Chimangul
authors.forename: K
authors.initials: K
authors.lastname: Minemura
authors.forename: K
authors.initials: K
authors.lastname: Utsumi
authors.forename: M
authors.initials: M
authors.lastname: Yonemaru
authors.forename: H
authors.initials: H
authors.lastname: Serizawa
authors.forename: Y
authors.initials: Y
authors.lastname: Ebihara
authors.forename: K
authors.initials: K
authors.lastname: Toyama
mesh_terms: D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008175:Lung Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism*; D008875:Middle Aged; D018202:Pulmonary Blastoma / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism*; D013902:Radiography, Thoracic; D012595:Scleroderma, Systemic / Q000150:complications*; D014057:Tomography, X-Ray Computed; D000509:alpha-Fetoproteins / Q000096:biosynthesis*
chemical_list: D000509:alpha-Fetoproteins