title: [Molecular mechanisms of prostatic oncogenesis].
abstract: A model of effector and regulatory determinants of the rate and coordination of proliferation of epithelial and stromal cells in the normal prostate in benign hyperplasia and cancer of the prostate was developed. The direct effector factors-protein growth factors, the regulatory factors: activators (5-alpha-reductase, dehydrotestosterone, prostatic specific antigen) and inhibitors (tumor suppressors and metastatic suppressors, insulin-like growth factor-binding protein type 3) were analyzed and systematized. The molecular mechanisms responsible for the occurrence and progression of prostatic tumors, the role of the above factors, genetic changes in the chromosomes and genes, impaired coordination in the action of oncogenes and antioncogenes were under investigation. Directions of experimental search for the earlier unknown links in the analyzed system are outlined. The prospects for designing and using new diagnostic and prognostic omcomarkers and new means for the prevention and treatment of benign hyperplasia and cancer of the prostate are defined.
authors.forename: E G
authors.initials: EG
authors.lastname: Zezerov
authors.forename: E S
authors.initials: ES
authors.lastname: Severin
mesh_terms: D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000235:genetics / Q000378:metabolism; D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D002455:Cell Division; D004848:Epithelium / Q000378:metabolism / Q000473:pathology; D016147:Genes, Tumor Suppressor / Q000235:genetics; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000235:genetics / Q000378:metabolism; D008297:Male; D009857:Oncogenes / Q000235:genetics; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000235:genetics / Q000378:metabolism; D011470:Prostatic Hyperplasia / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D017154:Stromal Cells / Q000378:metabolism / Q000473:pathology; D013739:Testosterone / Q000031:analogs & derivatives / Q000235:genetics / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D018972:Insulin-Like Growth Factor Binding Protein 3; D013739:Testosterone; C013915:boldenone; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase; D017430:Prostate-Specific Antigen
vernacular_title: Molekuliarnye mekhanismy onkogeneza predstatel'noĭ zhelezy.