title: Ischemia/reperfusion injury in flow-through venous flaps.
abstract: The effects of ischemia/reperfusion (I/R) injury in flow-through venous flaps were evaluated in rabbits. The rates of flap survival and the levels of lipid peroxidation, protein oxidation, and sulfhydryl groups were compared between flow-through venous flaps, conventional flaps after an I/R period (experimental groups), and flow-through venous flaps without being subjected to I/R injury (control groups) in 20 animals. On the seventh day after the onset of reperfusion, 3 of 10 flow-through venous flaps (30%) and 6 of 10 arteriovenous flaps (60%) survived in the experimental groups. Flow-through venous flaps showed a decreased survival rate compared with control and conventional flaps (p < 0.05). Tissue lipid peroxide levels were found to be higher in venous flaps during reperfusion after secondary ischemia (p < 0.05). Tissue protein oxidation and total sulfhydryl groups levels did not show any difference among groups. This study suggests that more free radical damage occurs in flow-through venous flaps during I/R injury.
authors.affiliation: Department of Plastic and Reconstructive Surgery, School of Medicine, Dokuz Eylül University, Izmir, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Atabey
authors.forename: S
authors.initials: S
authors.lastname: Gezer
authors.forename: H
authors.initials: H
authors.lastname: Vayvada
authors.forename: G
authors.initials: G
authors.lastname: Kirkali
authors.forename: A
authors.initials: A
authors.lastname: Menderes
authors.forename: C
authors.initials: C
authors.lastname: Karaca
authors.forename: A
authors.initials: A
authors.lastname: Barutçu
mesh_terms: D000818:Animals; D015227:Lipid Peroxidation; D009336:Necrosis; D011817:Rabbits; D015427:Reperfusion Injury / Q000503:physiopathology*; D013524:Surgical Flaps / Q000098:blood supply* / Q000473:pathology / Q000502:physiology