title: Degradation of dioxin-like compounds by microorganisms.
abstract: Polychlorinated dibenzo-p-dioxins (PCDD) and polychlorinated dibenzofurans (PCDF; PCDD/F, dioxins) have not been commercially produced in bulk amounts, as were polychlorinated biphenyls and other haloaromatic organics. Within the past two decades a lot of information has accumulated on the biodegradation of PCDD/F and other dioxin-like compounds because of their toxicity and because of significant environmental concern about many congeners of this class of chemicals. PCDD/F are subjected to reductive dehalogenations leading to less halogenated congeners, which can be attacked efficiently by fungal and bacterial oxidases and dioxygenases. In several cases these compounds can be utilized as carbon and energy sources. Pathways for their enzymatic degradation and the organisation of the corresponding degradative genes have been elucidated. Consequently, biotechnological applications will exploit the degradative potential of such microorganisms for bioremediation of contaminated sites.
authors.affiliation: Gesellschaft für Biotechnologische Forschung-GBF, Braunschweig, Germany. wittich@gbf.de
authors.forename: R M
authors.initials: RM
authors.lastname: Wittich
mesh_terms: D001419:Bacteria / Q000378:metabolism*; D001572:Benzofurans / Q000378:metabolism; D001673:Biodegradation, Environmental; D000072338:Dibenzofurans, Polychlorinated; D004147:Dioxins / Q000378:metabolism*; D005658:Fungi / Q000378:metabolism*; D019015:Geologic Sediments; D010084:Oxidation-Reduction; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives / Q000378:metabolism; D012988:Soil Microbiology
chemical_list: D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D004147:Dioxins; D000072317:Polychlorinated Dibenzodioxins