title: Cinoxacin complexes with divalent metal ions. Spectroscopic characterization. Crystal structure of a new dinuclear Cd(II) complex having two chelate-bridging carboxylate groups. Antibacterial studies.
abstract: Several cinoxacin (HCx) complexes with divalent metal ions have been prepared and characterized by spectroscopic techniques. The crystal structure of [Cd2(Cx)4(H2O)2].10H2O has been determined by X-ray diffraction. The complex is triclinic, space group P1 with unit-cell dimensions: a = 10.412(2), b = 11.119(2), c = 13.143(6)A, chi== 76.78(4) degrees, beta = 74.59(3) degrees, gamma = 77.12(3) degrees, V = 1406.0(8) A3. In this complex each cadmium atom is heptacoordinated: the metal environment is formed by two Oketo and two Ocarbox atoms from two different cinoxacinate monoanions, two carboxylate oxygen atoms from a third cinoxacinate ligand and by one water oxygen atom on the seventh position. Two of the cinoxacinate ions act as tridentate chelate and bridging ligands and the other one as a bidentate chelate ligand. In the bridging monoanions the carboxylate group is behaving as a chelate ligand. All the complexes were screened for their activity against several bacteria, showing activity similar to that of cinoxacin. Additionally, the number of bacteria killed after 3 h of incubation with cinoxacin, [Cu(Cx)2].2H2O and [Co(Cx)3]Na.10H2O complexes was determined against E. coli ATCC 25922; the copper compound presents paradoxical effect which has been described and related to the mechanism of action of quinolones.
authors.affiliation: Departamento de Química Inorgánica, Faculdad de Farmacia, Universidad de Valencia, Burjassot (Valencia), Spain.
authors.forename: M
authors.initials: M
authors.lastname: Ruíz
authors.forename: L
authors.initials: L
authors.lastname: Perelló
authors.forename: J
authors.initials: J
authors.lastname: Server-Carrió
authors.forename: R
authors.initials: R
authors.lastname: Ortiz
authors.forename: S
authors.initials: S
authors.lastname: García-Granda
authors.forename: M R
authors.initials: MR
authors.lastname: Díaz
authors.forename: E
authors.initials: E
authors.lastname: Cantón
mesh_terms: D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D002104:Cadmium; D002264:Carboxylic Acids / Q000737:chemistry; D002614:Chelating Agents; D002937:Cinoxacin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D042462:4-Quinolones; D000890:Anti-Infective Agents; D002264:Carboxylic Acids; D002614:Chelating Agents; D009942:Organometallic Compounds; C096135:bis(cinoxacinate)copper(II); D002104:Cadmium; D002937:Cinoxacin