Effect of EMD 57445, the selective sigma receptor ligand, on the turnover and release of dopamine.
EMD 57445 (1, 3 and 10 mg/kg, po), a selective sigma receptor ligand without an affinity to dopamine receptors, induced potent, dose-dependent increases in the tissue DOPAC and HVA levels in the rat brain cortex, nucleus accumbens and striatum. The extracellular DOPAC and HVA levels after EMD 57445 and (3 and 10 mg/kg, po) administrations, measured by microdialysis in the rat prefrontal cortex, were also increased, without significant effects on the outflow of dopamine.
Skuza
G
G
Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
Gołembiowska
K
K
Wedzony
K
K
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D008297:Male; D017551:Microdialysis; D010080:Oxazoles / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D014150:Antipsychotic Agents; D010080:Oxazoles; D010880:Piperidines; C103849:panamesine; D004298:Dopamine