title: Allogenic grafting of vascularized bone segments under immunosuppression. Clinical results in the transplantation of femoral diaphyses.
abstract: Trauma surgery lack, substitute, for the reconstruction of large defects of the long bones. Encouraged by the promising results of bone allotransplantation in animal models, we successfully performed vascularized bone transplantation in humans. Vascularized femoral diaphyses were allogenically transplanted into three patients suffering from chondrosarcoma or post-traumatic osteomyelitis with postoperative immunosuppression. The bone segments were harvested from multi-organ donors and perfused with UW solution. After back-table preparation, the grafts were transplanted into the defect zone. Interlocking devices were used in these operations. Vascular anastomoses were performed in end-to-side technique. The early clinical course of the patients was not free of anatomical, technical, or immunological complications. However, all patients are currently free of malignancy and infection. They are also free of pain and full weight bearing. We conclude that allogenic grafting of vascularized bone segments has the potential to become an alternative for the replacement of large bone defects.
authors.affiliation: Department of Surgery, Ludwig-Maximilians University Munich, Germany. kirschner@icf.med.uni-muenchen.de
authors.forename: M H
authors.initials: MH
authors.lastname: Kirschner
authors.forename: F D
authors.initials: FD
authors.lastname: Wagner
authors.forename: A
authors.initials: A
authors.lastname: Nerlich
authors.forename: W
authors.initials: W
authors.lastname: Land
authors.forename: V
authors.initials: V
authors.lastname: Bühren
authors.forename: G O
authors.initials: GO
authors.lastname: Hofmann
mesh_terms: D000328:Adult; D001163:Arteriovenous Anastomosis; D001859:Bone Neoplasms / Q000601:surgery; D016025:Bone Transplantation / Q000379:methods*; D002813:Chondrosarcoma / Q000601:surgery; D018483:Diaphyses / Q000637:transplantation*; D005269:Femur / Q000637:transplantation*; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D018919:Neovascularization, Physiologic; D010019:Osteomyelitis / Q000601:surgery
chemical_list: D007166:Immunosuppressive Agents