Direct enantiomeric separation of mianserin and 6-azamianserin derivatives using chiral stationary phases.
The direct enantiomeric separation of mianserin and 6-azamianserin and some of their derivatives, respectively, by means of HPLC using two different chiral selectors was investigated. For the cellulose-based Chiralcel OD column, a strong dependence of the lipophilicity of the compounds tested on the retention behaviour was observed. To some extent, this was also found for the enantiomeric separation on the amylose-based Chiralpak AD column. In some cases a complementary behaviour of these two phases was observed: racemic mixtures that could not be separated by one column could be resolved by the other one.
Selditz
U
U
Groningen Institute for Drug Studies, Department of Analytical Chemistry and Toxicology, The Netherlands.
Liao
Y
Y
Franke
J P
JP
de Zeeuw
R A
RA
Wikström
H
H
D000317:Adrenergic alpha-Antagonists / Q000032:analysis* / Q000737:chemistry; D000688:Amylose / Q000737:chemistry; D000928:Antidepressive Agents / Q000032:analysis* / Q000737:chemistry; D002482:Cellulose / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D008803:Mianserin / Q000031:analogs & derivatives* / Q000032:analysis* / Q000737:chemistry; D000078785:Mirtazapine; D012702:Serotonin Antagonists / Q000032:analysis* / Q000737:chemistry; D013237:Stereoisomerism
D000317:Adrenergic alpha-Antagonists; D000928:Antidepressive Agents; D012702:Serotonin Antagonists; D008803:Mianserin; D002482:Cellulose; D000688:Amylose; D000078785:Mirtazapine