title: [Mortality and worsening of prognosis for patients with aortic stenosis while on the waiting list].
abstract: In a prospective study, 99 consecutive patients with an operative indication due to severe aortic stenosis (AS) were put on a surgical waiting list. The waiting time to aortic valve replacement (AVR) averaged 6.3 months (0.5-19 months). There were 58 men and 41 women with a mean age of 61 years (21-82 years). The patients were divided into three groups: group 1 (N = 81) with an uneventful stay on the waiting list; group 2 (N = 11) with significant worsening of a prognostic index; and group 3 (N = 7) with patients who died during the waiting time. The waiting list death rate was 13.5%/patient-year compared with a post-AVR death rate of 4.9% patient-year (p < 0.05) with a mean post-AVR follow-up of 5.7 years. According to a prognostic index (Cox regression model) at inclusion, group 2 patients had a predicted 7-year post-AVR survival probability of 72%, but only of 61% according to their prognostic index immediately preoperatively; their observed 7-year post-AVR survival was 60%. Logistic regression analysis identified high age, short duration of symptoms, signs of severe hypertrophy and strain in the ECG, female gender, and deranged left ventricular diastolic function (related to severely increased left ventricular muscle mass) as independent predictors of prognostic worsening and death while on the waiting list. The predictive models did not allow sufficiently accurate identification of the patients at risk during the waiting period. The consequences of a surgical waiting period averaging 6 months are serious for AS patients. The death rate is high and a subgroup worsens its prognostic profile with a significantly reduced post-AVR long-term survival as the result.
authors.affiliation: Arhus Universitetshospital Skejby Sygehus, hjerte-lunge-karkirurgisk afdeling.
authors.forename: O
authors.initials: O
authors.lastname: Lund
authors.forename: T T
authors.initials: TT
authors.lastname: Nielsen
authors.forename: K
authors.initials: K
authors.lastname: Emmertsen
authors.forename: C
authors.initials: C
authors.lastname: Flø
authors.forename: B S
authors.initials: BS
authors.lastname: Rasmussen
authors.forename: F T
authors.initials: FT
authors.lastname: Jensen
authors.forename: H K
authors.initials: HK
authors.lastname: Pilegaard
authors.forename: L H
authors.initials: LH
authors.lastname: Kristensen
authors.forename: O K
authors.initials: OK
authors.lastname: Hansen
mesh_terms: D000328:Adult; D000368:Aged; D001024:Aortic Valve Stenosis / Q000175:diagnosis / Q000401:mortality* / Q000601:surgery; D003718:Denmark; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D013997:Time Factors; D014850:Waiting Lists
vernacular_title: Mortalitet og prognoseforringelse for patienter med aortastenose på kirurgisk venteliste.