Anti-viral immunity: spotting virus-specific T cells.
Historically, quantitation of virus-specific CD8+ T cells has been accomplished by limiting dilution analysis of cytotoxic precursor cells. Recent studies have shown that this technique greatly underestimates the actual number of antigen-specific cells and have provided new insight into anti-viral immune responses.
Tough
D F
DF
Edward Jenner Institute for Vaccine Research, Newbury, Berkshire, UK.
Sprent
J
J
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology*; D003602:Cytotoxicity, Immunologic; D006801:Humans; D008285:Major Histocompatibility Complex; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology; D014780:Viruses / Q000276:immunology*
D011948:Receptors, Antigen, T-Cell