title: AIDS-related Mycobacterium kansasii infection with initial resistance to clarithromycin.
abstract: Clarithromycin is a promising drug for the treatment of Mycobacterium kansasii infection. We report a patient with AIDS and severe M. kansasii infection who had previously received a short course of clarithromycin for sinusitis. He had clinical failure of treatment using clarithromycin plus ethambutol, and the initial isolate was found to be highly resistant to clarithromycin. Nucleotide sequencing of the 23S rRNA gene of this isolate demonstrated a single base mutation at position 2058, the same as that found in clarithromycin-resistant Mycobacterium avium.
authors.affiliation: Denver Health Medical Center, Department of Medicine, University of Colorado Health Sciences Center, USA.
authors.forename: W J
authors.initials: WJ
authors.lastname: Burman
authors.forename: B L
authors.initials: BL
authors.lastname: Stone
authors.forename: B A
authors.initials: BA
authors.lastname: Brown
authors.forename: R J
authors.initials: RJ
authors.lastname: Wallace
authors.forename: E C
authors.initials: EC
authors.lastname: Böttger
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy* / Q000382:microbiology; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017291:Clarithromycin / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D006801:Humans; D009165:Mycobacterium Infections, Nontuberculous / Q000188:drug therapy* / Q000382:microbiology; D019909:Mycobacterium kansasii / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D017291:Clarithromycin