title: The effect of hysterectomy and endometrial ablation on follicle stimulating hormone (FSH) levels up to 1 year after surgery.
abstract: OBJECTIVE
  In this study the hypothesis was tested, that in premenopausal patients FSH-levels would rise after 'simple hysterectomy'. As endometrial ablation is not supposed to compromise ovarian bloodflow, there would be no such change in ablated patients.
  
  
  METHODS
  Between January 1995 and April 1996, consecutive premenopausal patients with dysfunctional uterine bleeding who were scheduled for hysterectomy or endometrial ablation were asked to participate in the study. Bloodsamples were drawn before surgery, six weeks, six months and one year after surgery. FSH and oestradiol (E2) were assayed. In all patients data about length and weight were collected to calculate Body Mass Index (BMI). Every visit patients filled in a questionnaire, containing questions about typical climacteric complaints, combined in a five-point scale.
  
  
  RESULTS
  Except for a significant difference in preoperative FSH-level between both groups, there were no significant differences regarding age, Body Mass Index (BMI), oestradiol (E2) or the percentage of women with vasomotor complaints. Compared to the preoperative starting level, six weeks, six months and one year after surgery a significant rise in serum FSH in the hysterectomy group, as well as in the ablation group was found. However there was no significant difference in FSH increase between both groups. One third of the patients in both groups had typical climacteric complaints as flushing and nocturnal sweating.
  
  
  CONCLUSIONS
  Assaying serum FSH-levels before and after uterine surgery and comparing hysterectomized patients and patients after endometrial ablation, we found a significant rise in FSH-level up to one year after surgery in both groups postoperatively, indicating impaired ovarian function. There was no difference in FSH-levels between both groups. Therefore major uterine surgery (hysterectomy, ablation) may prelude an earlier onset of menopause.
authors.affiliation: Department of Obstetrics and Gynecology, University Hospital, Utrecht, The Netherlands.
authors.forename: J G
authors.initials: JG
authors.lastname: Derksen
authors.forename: H A
authors.initials: HA
authors.lastname: Brölmann
authors.forename: M A
authors.initials: MA
authors.lastname: Wiegerinck
authors.forename: H L
authors.initials: HL
authors.lastname: Vader
authors.forename: A P
authors.initials: AP
authors.lastname: Heintz
mesh_terms: D000328:Adult; D004598:Electrosurgery; D004717:Endometrium / Q000601:surgery*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D007044:Hysterectomy; D017697:Premenopause / Q000097:blood; D014592:Uterine Hemorrhage / Q000097:blood / Q000601:surgery
chemical_list: D005640:Follicle Stimulating Hormone