title: Dehydroradiosumin, a trypsin inhibitor from the cyanobacterium Anabaena cylindrica.
abstract: Dehydroradiosumin, a novel potent trypsin inhibitory dipeptide, was isolated from the freshwater cyanobacterium Anabaena cylindrica (NIES-19). Its structure was elucidated as 1 on the basis of 2D NMR data and chemical degradation. The IC50 of 1 against trypsin was 0.1 microg/mL.
authors.affiliation: Laboratory of Marine Biochemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kodani
authors.forename: K
authors.initials: K
authors.lastname: Ishida
authors.forename: M
authors.initials: M
authors.lastname: Murakami
mesh_terms: D017033:Anabaena / Q000737:chemistry*; D002240:Carbohydrate Sequence; D004151:Dipeptides / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008969:Molecular Sequence Data; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014361:Trypsin Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D004151:Dipeptides; D014361:Trypsin Inhibitors; C113242:dehydroradiosumin