title: [Comparison of the multifactorial model as a hereditary mechanism of non-myoclonic generalized idiopathic epilepsy and partial idiopathic epilepsy].
abstract: OBJECTIVE
  An experimental study about the predictions from the multifactorial threshold model created by Falconer is presented, assuming that this model may explain the genetic mechanisms underlying the family aggregation of idiopathic epilepsies.
  
  
  RESULTS
  We failed to confirm the following predictions from the falconer model: decreased prevalence of disease in relatives, proportional to decreased family links, and the order of birth effect. An heredity greater than 100% was calculated which is concordant with the presence of at least a locus with a major gen affect.
  
  
  CONCLUSIONS
  Our results reject the multifactorial threshold effect and suggest the presence of a major gen or Mendelian effect. An analysis of complex segregation is suggested for future studies.
authors.affiliation: Instituto Neurológico de Antioquia, Universidad de Antioquia, Medellin, Columbia.
authors.forename: J L
authors.initials: JL
authors.lastname: Sánchez
authors.forename: I
authors.initials: I
authors.lastname: Jiménez
authors.forename: L G
authors.initials: LG
authors.lastname: Palacio
authors.forename: M
authors.initials: M
authors.lastname: Jiménez
authors.forename: O
authors.initials: O
authors.lastname: Mora
authors.lastname: López-Gardner
authors.forename: L
authors.initials: L
authors.lastname: Zuluaga
authors.forename: C S
authors.initials: CS
authors.lastname: Uribe
authors.forename: R
authors.initials: R
authors.lastname: Isaza
authors.forename: A
authors.initials: A
authors.lastname: Villa
authors.forename: R
authors.initials: R
authors.lastname: Blanco
authors.forename: M
authors.initials: M
authors.lastname: Arcos-Burgos
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D017668:Age of Onset; D002648:Child; D018450:Disease Progression; D004827:Epilepsy / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D015995:Prevalence; D017678:Sex Distribution
vernacular_title: Contraste del modelo multifactorial como mecanismo hereditario de epilepsia idiopática generalizada no mioclónica y de epilepsia idiopática parcial.