Cerebral hypoperfusion during acute Kawasaki disease.
OBJECTIVE
Kawasaki disease is a febrile disease of children notable for systemic vasculitis. There have been many previous reports of various complications, including disorders of the central nervous system. We evaluated cerebral perfusion during the acute stage in patients with Kawasaki disease.


METHODS
Single-photon emission-computed tomography (SPECT) with 99mTc-hexamethylpropyleneamine oxime was performed in 21 children with acute stage Kawasaki disease. Follow-up SPECT and MRI were performed about 1 month after the first SPECT in patients who exhibited abnormal SPECT findings during the acute stage.


RESULTS
In 6 of 21 children SPECT imaging demonstrated localized cerebral hypoperfusion without abnormal neurological findings or clinical symptoms, and the follow-up SPECT and MRI approximately 1 month after the first SPECT revealed no abnormalities.


CONCLUSIONS
Some patients with Kawasaki disease have transient localized cerebral hypoperfusion at the acute stage.
Ichiyama
T
T
Department of Pediatrics, Yamaguchi University School of Medicine, Ube, Japan.
Nishikawa
M
M
Hayashi
T
T
Koga
M
M
Tashiro
N
N
Furukawa
S
S
D000208:Acute Disease; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime