title: Mathematical model for the blood coagulation prothrombin time test.
abstract: A mathematical model for the prothrombin time test is proposed. The time course of clotting factor activation during coagulation was calculated, and the sensitivity of the test to a decrease in the concentrations of coagulation proteins or their activities was studied. The model predicts that only severe coagulation disorders connected with a more than five-fold decrease in the concentrations or activities of the blood coagulation factors can be revealed by the test.
authors.affiliation: Laboratory of Theoretical Biology, Russian State University of Technology, Moscow. khanin@landau.ac.ru
authors.forename: M A
authors.initials: MA
authors.lastname: Khanin
authors.forename: D V
authors.initials: DV
authors.lastname: Rakov
authors.forename: A E
authors.initials: AE
authors.lastname: Kogan
mesh_terms: D001779:Blood Coagulation Factors / Q000032:analysis; D001780:Blood Coagulation Tests; D006801:Humans; D008954:Models, Biological; D010314:Partial Thromboplastin Time; D012680:Sensitivity and Specificity
chemical_list: D001779:Blood Coagulation Factors