[Neurosteroids. Neuromodulators of cerebral excitability].
Steroids which are produced by the brain are called neurosteroids, and they are able to modulate neurotransmissions: GABAergic; glutamatergic; glycinergic, and cholinergic (nicotine receptor). These effects are of short latency and duration, and do not implicate the cellular genome. The interaction of these neurosteroids with membrane receptors contribute to the regulation of neuronal excitability, and their study has allowed a better understanding of cognitive, hormonal, and epileptic phenomena as well as the development of new drugs with anxiolytic, antidepressive, anesthetic and anti-epileptic effects.
Calixto González
E
E
Departamento de Neurociencias, Instituto de Fisiología Celular y Fisiología Humana, Facultad de Medicina, UNAM, México.
Brailowsky
S
S
D000305:Adrenal Cortex Hormones / Q000494:pharmacology / Q000502:physiology; D000328:Adult; D000368:Aged; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D003863:Depression / Q000503:physiopathology; D004644:Emotions / Q000187:drug effects / Q000502:physiology; D004827:Epilepsy / Q000503:physiopathology; D005260:Female; D012739:Gonadal Steroid Hormones / Q000494:pharmacology / Q000502:physiology; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000503:physiopathology; D015213:Neuroimmunomodulation; D018377:Neurotransmitter Agents / Q000502:physiology*; D011247:Pregnancy; D051381:Rats; D018079:Receptors, GABA / Q000187:drug effects / Q000502:physiology; D017470:Receptors, Glutamate / Q000187:drug effects / Q000502:physiology; D018009:Receptors, Glycine / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects / Q000502:physiology; D011978:Receptors, Nicotinic / Q000187:drug effects / Q000502:physiology; D012098:Reproduction / Q000502:physiology; D015290:Second Messenger Systems / Q000502:physiology; D014981:Xenopus
D000305:Adrenal Cortex Hormones; D012739:Gonadal Steroid Hormones; D018377:Neurotransmitter Agents; D018079:Receptors, GABA; D017470:Receptors, Glutamate; D018009:Receptors, Glycine; D016194:Receptors, N-Methyl-D-Aspartate; D011978:Receptors, Nicotinic
Neuroesteroides. Neuromoduladores de la excitabilidad cerebral.