Interferon-beta inhibits mitogen induced astrocyte proliferation in vitro.
The central nervous system response to injury and inflammation commonly includes astrocytosis. This process, which is manifest by astrocyte hypertrophy and proliferation, is particularly prominent in multiple sclerosis (MS), where in chronic lesions it may contribute to the lack of repair by restricting the migration of remyelinating cells. Interferon-beta (IFN-beta) modestly reduces the frequency of relapses in MS and may have a small effect on the accumulation of permanent disability. Here, we show that IFN-beta inhibits the in vitro proliferative response of rodent astrocytes to a wide variety of growth factors and cytokines. Although important species differences exist in these glial responses this previously unrecognised property of IFN-beta may have implications for reducing astrocytosis and thereby promoting endogenous repair.
Malik
O
O
Department of Neurology, Addenbrooke's Hospital, Cambridge, UK. om200@hermes.cam.ac.uk
Compston
D A
DA
Scolding
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NJ
D000818:Animals; D000831:Animals, Newborn; D000906:Antibodies / Q000494:pharmacology; D000918:Antibody Specificity; D001253:Astrocytes / Q000737:chemistry / Q000166:cytology* / Q000187:drug effects*; D001667:Binding, Competitive / Q000276:immunology; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D016207:Cytokines / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D016899:Interferon-beta / Q000276:immunology* / Q000494:pharmacology*; D008934:Mitogens / Q000494:pharmacology*; D009103:Multiple Sclerosis / Q000276:immunology; D009500:Neutralization Tests; D051381:Rats; D017207:Rats, Sprague-Dawley
D000906:Antibodies; D016207:Cytokines; D005904:Glial Fibrillary Acidic Protein; D008934:Mitogens; D016899:Interferon-beta