Heparin-induced thrombocytopenia, paradoxical thromboembolism, and other side effects of heparin therapy.
Although several new anticoagulant drugs are in development, heparin remains the drug of choice for most anticoagulation needs. The clinical effects of heparin are meritorious, but side effects do exist. Important untoward effects of heparin therapy including heparin-induced thrombocytopenia, heparin-associated osteoporosis, eosinophilia, skin reactions, allergic reactions other than thrombocytopenia and alopecia will be discussed in this article.
Walenga
J M
JM
Department of Thoracic-Cardiovascular Surgery, Loyola University Medical Center, Maywood, Illinois 60153, USA.
Bick
R L
RL
D000818:Animals; D000925:Anticoagulants / Q000009:adverse effects* / Q000627:therapeutic use; D019320:Embolism, Paradoxical / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D005343:Fibrinolytic Agents / Q000009:adverse effects*; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D010024:Osteoporosis / Q000139:chemically induced / Q000175:diagnosis; D012871:Skin Diseases / Q000139:chemically induced / Q000175:diagnosis; D013917:Thrombin / Q000037:antagonists & inhibitors; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D013923:Thromboembolism / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy
D000925:Anticoagulants; D005343:Fibrinolytic Agents; D006493:Heparin; D013917:Thrombin