Molecular cloning and characterisation of a mouse gene encoding an isoform of the neuronal cyclin-dependent kinase 5 (CDK5) activator.
We have isolated and characterised the mouse gene for the p39 activator, designated p39is, which encodes a protein of 369 amino acids. The mouse p39 protein exhibits 95% amino acid identity to a previously characterised human p39 cDNA and the novel gene sequence corresponds to a single genomic locus in mouse. The p39is mRNA is highly expressed in the mouse central nervous system.
Nildén
F
F
Department of Developmental Neuroscience, Uppsala University, BMC, Box 587, 751 23 Uppsala, Sweden.
Bäckström
A
A
Bark
C
C
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D051360:Cyclin-Dependent Kinase 5; D018844:Cyclin-Dependent Kinases; D018076:DNA, Complementary; D004789:Enzyme Activation; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009474:Neurons / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid
C108298:Cdk5 activator p39; D018076:DNA, Complementary; D009419:Nerve Tissue Proteins; D051360:Cyclin-Dependent Kinase 5; D017346:Protein Serine-Threonine Kinases; C495905:CDK5 protein, human; C495906:Cdk5 protein, mouse; D018844:Cyclin-Dependent Kinases