1-Aminocylopropane-1-carboxylic acid derivatives as ligands at the glycine-binding site of the N-methyl-D-aspartate receptor.
Several 1-aminocyclopropane-1-carboxylic acid derivatives were prepared and tested for activity at the glycine-binding site of the N-methyl-D-aspartate (NMDA) receptor complex. Structural modifications involved the amino group, the carboxylic function or position 2 of the ring. When tested in a [3H]-MK-801 binding assay in the presence of glutamic acid, some of the compounds were able to activate the receptor. Two of them (3e and 6) are selective ligands for the glycine site of the NMDA receptor.
Balsamini
C
C
Istituto di Chimica Farmaceutica, Università di Urbino, Italy.
Bedini
A
A
Spadoni
G
G
Tarzia
G
G
Tontini
A
A
Balduini
W
W
Cimino
M
M
D000596:Amino Acids / Q000737:chemistry* / Q000378:metabolism*; D000598:Amino Acids, Cyclic; D001665:Binding Sites; D005998:Glycine / Q000378:metabolism*; D008024:Ligands; D015394:Molecular Structure; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*
D000596:Amino Acids; D000598:Amino Acids, Cyclic; D008024:Ligands; D016194:Receptors, N-Methyl-D-Aspartate; C023863:1-aminocyclopropane-1-carboxylic acid; D005998:Glycine