[Experimental endocarditis. Pathological anatomy of human endocarditis].
Experimental reproduction of human endocarditis in animal models has been based on the induction of structural lesions in valve endocardium using different methods. The primary lesion caused in this way is the so called non-bacterial thrombotic endocarditis. Its colonization is then induced by inoculation of microorganisms in the bloodstream. Freedman's modified method has been the most widespread model of this type. It has mainly been performed in rabbits with inoculation of Staphylococcus aureus or alpha-hemolitic Streptococcus. Experimental models of endocarditis have contributed to our knowledge of the pathogenic mechanisms, causative agents and predisposing factors of endocarditis. They have also allowed us to develop appropriate diagnostic, therapeutic and prophylactic measures for its management.
Alonso Pulpón
L
L
Servicio de Cardiología, Clínica Puerta de Hierro, Madrid.
Tejero Romero
C
C
Segovia Cubero
J
J
Sanmartín Fernández
M
M
Cristóbal Varela
C
C
Gallego Page
J C
JC
D000818:Animals; D004285:Dogs; D004697:Endocarditis, Bacterial / Q000209:etiology / Q000473:pathology*; D004699:Endocardium / Q000473:pathology; D006439:Hemodynamics; D006801:Humans; D011817:Rabbits; D012307:Risk Factors
Endocarditis experimental. Anatomía patológica de la endocarditis humana.