Rhinocerebral mucormycosis treated with amphotericin B colloidal dispersion in three patients.
Rhinocerebral mucormycosis (zygomycosis) primarily affects diabetic or immunosuppressed patients and typically progresses rapidly, necessitating surgical excision and antifungal therapy with amphotericin B. Large doses of amphotericin B are required for cure, causing significant renal toxicity. Amphotericin B colloidal dispersion (ABCD; Amphocil, Sequus Pharmaceuticals, Menlo Park, CA) is a 1:1 complex of cholesteryl sulfate and amphotericin B, which results in significant reduction of toxicity, especially nephrotoxicity. We describe three patients with life-threatening rhinocerebral mucormycosis treated with ABCD. All patients had high serum creatinine levels due to prior treatment with amphotericin B; these levels reverted to normal during treatment with ABCD. Two patients with diabetes mellitus were cured after receiving a combination of surgery and ABCD therapy. The third patient, who had myelodysplastic syndrome, had an initial good response, with cure of the fungal infection; however, he eventually died of his primary illness. To the best of our knowledge, this is the first detailed clinical description of the treatment of mucormycosis with ABCD.
Moses
A E
AE
Departments of Clinical Microbiology and Infectious Diseases, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Rahav
G
G
Barenholz
Y
Y
Elidan
J
J
Azaz
B
B
Gillis
S
S
Brickman
M
M
Polacheck
I
I
Shapiro
M
M
D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000188:drug therapy*; D009894:Opportunistic Infections / Q000188:drug therapy; D010254:Paranasal Sinus Diseases / Q000188:drug therapy* / Q000382:microbiology
D000935:Antifungal Agents; D000666:Amphotericin B; D003404:Creatinine