Obstruction of the renal pelvis due to an insoluble blood clot after epsilon-aminocaproic acid therapy: resolution with intraureteral streptokinase instillations.
OBJECTIVE
We demonstrate the effectiveness of intraureteral streptokinase instillations for the resolution of an insoluble blood clot in the renal pelvis.


METHODS
A patient with renal adenocarcinoma had prolonged hematuria related to involvement of the "pyelum" by the tumor. An insoluble blood clot obstruction of the left renal collecting system developed as a consequence of epsilon aminocaproic acid therapy, which was treated with low dose streptokinase through a ureteral catheter.


RESULTS
Complete resolution of the clot and obstruction occurred within 3 days of therapy.


CONCLUSIONS
This relatively simple approach should be used for the treatment of obstruction before radical surgery is performed.
Wymenga
L F
LF
Department of Urology, Nij Smellinghe Hospital, Drachten, The Netherlands.
van der Boon
W J
WJ
D000368:Aged; D000369:Aged, 80 and over; D015119:Aminocaproic Acid / Q000009:adverse effects*; D000933:Antifibrinolytic Agents / Q000009:adverse effects*; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006801:Humans; D007322:Instillation, Drug; D007674:Kidney Diseases / Q000209:etiology; D007682:Kidney Pelvis; D013300:Streptokinase / Q000008:administration & dosage*; D013927:Thrombosis / Q000139:chemically induced* / Q000150:complications / Q000188:drug therapy*
D000933:Antifibrinolytic Agents; D005343:Fibrinolytic Agents; D013300:Streptokinase; D015119:Aminocaproic Acid