The role of IL-6 in the pathogenesis of periodontal disease.
The mechanisms underlying periodontal disease involve complex interactions between bacterial products, host cells and locally produced, biologically active factors. The umbrella term cytokine has been used to include a variety of such factors, including the interleukin family. The role of one cytokine, IL-1 beta, in periodontal disease pathogenesis has been widely reported. More recent studies have focused on a potential role for IL-6 in driving the destructive processes. Most of these reports have suggested a pro-inflammatory role for IL-6 alongside IL-1 and TNF-alpha. This manuscript reviews the biological functions of IL-6, specifically related to tissue destruction at the periodontal site. We would suggest that the activity of IL-6 in periodontal disease differs from IL-1 and TNF-alpha, and may, in part, play a protective role.
Irwin
C R
CR
Department of Restorative Dentistry, School of Clinical Dentistry, Queen's University, Belfast, UK.
Myrillas
T T
TT
D005109:Extracellular Matrix / Q000201:enzymology; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology*; D007375:Interleukin-1 / Q000502:physiology; D015850:Interleukin-6 / Q000096:biosynthesis / Q000502:physiology*; D010510:Periodontal Diseases / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D010519:Periodontium / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D018836:Inflammation Mediators; D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha