title: Induction and emergence in infants less than 60 weeks post-conceptual age: comparison of thiopental, halothane, sevoflurane and desflurane.
abstract: We have studied 40 infants with a post-conceptual age of less than 60 weeks undergoing general anaesthesia for herniotomy. Patients were anaesthetized with 1 MAC equivalent values for age and agent and allocated randomly to receive halothane, savoflurane or thiopental for induction, and halothane, sevoflurane or desflurane for maintenance of anaesthesia. At induction, both time to acceptance of a face mask and loss of eyelash reflex were recorded. Emergence times were noted by a blinded observer. Induction and emergence times were similar between the halothane and sevoflurane groups but were consistently shorter in the desflurane group compared with the halothane or sevoflurane groups. There were no problems at extubation or significant apnoea in any group. Induction of anaesthesia in this population was no quicker with sevoflurane than with halothane and the method used for induction did not influence recovery time. Maintenance of anaesthesia with desflurane resulted in a shorter recovery time in infants in whom anaesthesia was induced with halothane or thiopental. Desflurane maintenance may be particularly beneficial in the neonate.
authors.affiliation: Department of Anaesthesia, Royal Hospital for Sick Children, Yorkhill NHS Trust, Glasgow.
authors.forename: K
authors.initials: K
authors.lastname: O'Brien
authors.forename: D N
authors.initials: DN
authors.lastname: Robinson
authors.forename: N S
authors.initials: NS
authors.lastname: Morton
mesh_terms: D000762:Anesthesia Recovery Period; D019162:Anesthetics, Combined; D018685:Anesthetics, Inhalation / Q000009:adverse effects; D018686:Anesthetics, Intravenous; D000077335:Desflurane; D006221:Halothane; D006552:Hernia, Inguinal / Q000601:surgery; D006801:Humans; D007223:Infant; D007530:Isoflurane / Q000031:analogs & derivatives; D008738:Methyl Ethers; D011183:Postoperative Complications / Q000139:chemically induced; D012120:Respiration Disorders / Q000139:chemically induced; D000077149:Sevoflurane; D016037:Single-Blind Method; D013874:Thiopental
chemical_list: D019162:Anesthetics, Combined; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D008738:Methyl Ethers; D000077149:Sevoflurane; D000077335:Desflurane; D007530:Isoflurane; D013874:Thiopental; D006221:Halothane