title: A new class of cis-monobactam derivatives bearing a sulfamoyloxymethyl or an N-alkylsulfamoyloxymethyl group at position 4: synthesis and antibacterial activity.
abstract: A new series of monobactam derivatives, bearing unsubstituted or N-monosubstituted sulfamoyloxymethyl groups in position 4 was synthesized either in racemic or in optically active form. Their in vitro antibacterial activity was tested in comparison with carumonam 1a and its methoxyimino derivative 1b.
authors.affiliation: Dipartimento di Chimica e Chimica Industriale e C.N.R., Centro di Studi per la Chimica dei Composti Cicloalifatici ed Aromatici, Genoa, Italy. guanti@chimica unige.it
authors.forename: G
authors.initials: G
authors.lastname: Guanti
authors.forename: R
authors.initials: R
authors.lastname: Riva
authors.forename: G
authors.initials: G
authors.lastname: Cascio
authors.forename: E
authors.initials: E
authors.lastname: Manghisi
authors.forename: G
authors.initials: G
authors.lastname: Morandotti
authors.forename: G
authors.initials: G
authors.lastname: Satta
authors.forename: R
authors.initials: R
authors.lastname: Sperning
mesh_terms: D004926:Escherichia coli / Q000187:drug effects; D015394:Molecular Structure; D008997:Monobactams / Q000138:chemical synthesis* / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013457:Sulfur Compounds / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D008997:Monobactams; D013457:Sulfur Compounds