title: Association study between the -141C Ins/Del and TaqI A polymorphisms of the dopamine D2 receptor gene and alcoholism.
abstract: Dopamine D2 receptors have been implicated in the biology of alcohol preference. We examined the -141 C Ins/Del polymorphism in the promoter region of the dopamine D2 receptor gene (DRD2) and the DRD2 TaqI A polymorphisms in 209 Japanese alcoholics and 152 age- and sex-matched Japanese controls. The Ins allele was significantly increased in the alcoholics, compared with the controls (p < 0.002, odds ratio = 1.82). The TaqI A1 allele tended to be more frequent in the alcoholics than in the controls (p < 0.04). Linkage disequilibrium between these two polymorphisms was weak (a maximum delta value = 0.13). The -141 C Ins/Del polymorphism may affect the vulnerability for alcoholism presumably through different expression of DRD2 in the Japanese.
authors.affiliation: Department of Neuropsychiatry, Tokyo Medical and Dental University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ishiguro
authors.forename: T
authors.initials: T
authors.lastname: Arinami
authors.forename: T
authors.initials: T
authors.lastname: Saito
authors.forename: S
authors.initials: S
authors.lastname: Akazawa
authors.forename: M
authors.initials: M
authors.lastname: Enomoto
authors.forename: H
authors.initials: H
authors.lastname: Mitushio
authors.forename: H
authors.initials: H
authors.lastname: Fujishiro
authors.forename: K
authors.initials: K
authors.lastname: Tada
authors.forename: Y
authors.initials: Y
authors.lastname: Akimoto
authors.forename: H
authors.initials: H
authors.lastname: Mifune
authors.forename: S
authors.initials: S
authors.lastname: Shioduka
authors.forename: H
authors.initials: H
authors.lastname: Hamaguchi
authors.forename: M
authors.initials: M
authors.lastname: Toru
authors.forename: H
authors.initials: H
authors.lastname: Shibuya
mesh_terms: D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000235:genetics*; D000483:Alleles; D002872:Chromosome Deletion; D004251:DNA Transposable Elements / Q000235:genetics*; D005260:Female; D015870:Gene Expression / Q000502:physiology; D005787:Gene Frequency / Q000235:genetics; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D019914:Taq Polymerase / Q000235:genetics*
chemical_list: D004251:DNA Transposable Elements; D017448:Receptors, Dopamine D2; D019914:Taq Polymerase