Soluble Fc gamma receptors: interaction with ligands and biological consequences.
Soluble Fc gamma receptors are produced by cleavage of the membrane receptors or by alternative splicing. They are found in biologic fluids. After a brief description of the structure and mode of production of soluble Fc gamma R, we address the question of ligands and function of the soluble Fc gamma R by using recombinant molecules and transgenic animals. We show that soluble Fc gamma R are not only IgG-binding factors which interfere with, and block, Fc-dependent immune reactions but also molecules that interact, in vitro, with non-Ig-ligands such as CR3 and CR4 and are trigger or regulate immune functions via these receptors.
Galon
J
J
Unité INSERM 255, Institut Curie, Paris, France.
Paulet
P
P
Galinha
A
A
Lorès
P
P
Bonnerot
C
C
Jami
J
J
Fridman
W H
WH
Sautès
C
C
D000818:Animals; D006801:Humans; D008024:Ligands; D051379:Mice; D008822:Mice, Transgenic; D017452:Receptors, IgG / Q000276:immunology*; D012995:Solubility
D008024:Ligands; D017452:Receptors, IgG