Depressive symptoms and Depo-Provera.
Women enrolled in a multicenter prospective study were evaluated to identify any possible relationship between depressive symptoms and the use of contraceptives. Women choosing Depo-Provera (n = 495) were evaluated before starting these contraceptives and were reinterviewed 1 year later. Women who continued the method had lower depressive symptom scores at baseline than did the women who discontinued the method or who were lost to follow-up. Among the continuing Depo-Provera users, the depressive symptom scores improved slightly at 1 year (7.4 vs 6.7). Those subjects with the highest (i.e., worst) scores at enrollment demonstrated improved scores at follow-up.
Westhoff
C
C
College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Truman
C
C
Kalmuss
D
D
Cushman
L
L
Davidson
A
A
Rulin
M
M
Heartwell
S
S
D000293:Adolescent; D000328:Adult; D003271:Contraceptive Agents, Female / Q000009:adverse effects*; D003863:Depression / Q000139:chemically induced*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017258:Medroxyprogesterone Acetate / Q000009:adverse effects*; D019964:Mood Disorders / Q000139:chemically induced; D011446:Prospective Studies; D011795:Surveys and Questionnaires
D003271:Contraceptive Agents, Female; D017258:Medroxyprogesterone Acetate