title: Hyperreninaemic hypoaldosteronism in a dog.
abstract: A 9-year-old male German shepherd dog was evaluated for clinical and clinico-pathological changes that were suggestive of Addison's disease. On further investigation the basal plasma cortisol concentration was high, a normal cortisol response to ACTH stimulation occurred, plasma renin activity was elevated and low serum aldosterone concentration was present. A diagnosis of hyperreninaemic hypoaldosteronism was made. Replacement fludrocortisone resulted in complete normalisation of the electrolyte and fluid imbalances. Hyperreninaemic hypoaldosteronism has never been reported in the dog.
authors.affiliation: Department of Medicine, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa.
authors.forename: R G
authors.initials: RG
authors.lastname: Lobetti
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000097:blood / Q000175:diagnosis*; D004285:Dogs; D006854:Hydrocortisone / Q000097:blood; D006994:Hypoaldosteronism / Q000097:blood / Q000175:diagnosis / Q000662:veterinary*; D008297:Male; D012083:Renin / Q000097:blood*
chemical_list: D012083:Renin; D006854:Hydrocortisone