Exacerbation of atopic dermatitis after bacillus Calmette-Guérin vaccination.
In two children with atopic dermatitis, routine vaccination with bacillus Calmette-Guérin (BCG) was followed by severe exacerbation of skin disease. If the sequence is cause and effect, a possible mechanism is stimulation of a Th2 lymphocyte cytokine profile by the vaccine, with migration of activated lymphocytes to inflamed skin. In children with active atopic dermatitis, BCG vaccination is best deferred until remission.
Dalton
S J
SJ
Department of Child Health, University of Manchester, Booth Hall Children's Hospital, Blackley, UK.
Haeney
M R
MR
Patel
L
L
David
T J
TJ
D000367:Age Factors; D001500:BCG Vaccine / Q000009:adverse effects*; D002648:Child; D003876:Dermatitis, Atopic / Q000209:etiology* / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D014611:Vaccination / Q000009:adverse effects*
D001500:BCG Vaccine