Hypolipidemic effect of flavonoids from Solanum melongena.
Flavonoids extracted from the fruits of Solanum melongena (Brinjal) orally administered at a dose of 1 mg/100 g BW/day showed significant hypolipidemic action in normal and cholesterol fed rats. HMG CoA reductase activity was found to be enhanced, while activities of glucose-6-phosphate dehydrogenase and malate dehydrogenase were significantly reduced. Activities of lipoprotein lipase and plasma LCAT showed significant enhancement. A significant increase in the concentrations of hepatic and fecal bile acids and fecal neutral sterols was also observed indicating a higher rate of degradation of cholesterol.
Sudheesh
S
S
Department of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram, India.
Presannakumar
G
G
Vijayakumar
S
S
Vijayalakshmi
N R
NR
D000818:Animals; D001011:Aorta / Q000378:metabolism; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005419:Flavonoids / Q000494:pharmacology* / Q000627:therapeutic use; D005638:Fruit / Q000737:chemistry*; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D008099:Liver / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D002791:Cholesterol, Dietary; D005230:Fatty Acids, Nonesterified; D005419:Flavonoids; D000960:Hypolipidemic Agents; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases