[The initial level of motor activity determines the directivity of the motor effect of apomorphine].
In male mice of BALB/c and SHR strains with the highest base level of locomotion and rearings apomorphine (5 mg/kg) decreased these forms of motor activity while in C57BL/6 mice with the lowest base level of motor activity apomorphine increased it. In mice of C57BR and C3H/A strains with intermediate base level there was a tendency for an increase in activity. Extinction of exploratory motor activity in BALB/c as a result of four consecutive testings in the same experimental chamber with hourly intervals induced a decrease in activity of the animals by half. Being injected against this background the same dose of apomorphine (5 mg/kg) twice increased locomotion and rearings in these mice.
Lapin
I P
IP
Bekhterev Psychoneurological Research Institute, St.-Petersburg.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D018491:Dopamine Agonists / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology*; D013045:Species Specificity; D018709:Statistics, Nonparametric; D013997:Time Factors
D018491:Dopamine Agonists; D001058:Apomorphine
Iskhodnyĭ uroven' dvigatel'noĭ aktivnost' opredeliaet napravlennost' motornogo éffekta apomorfina.