Cognitive involvement by negative modulation of histamine H2 receptors in passive avoidance task in mice.
In this study, the intracerebroventricular administration of 4-methylhistamine (3 and 10 micrograms/head), a histamine H2 receptor agonist, shortened the step-through latency in the retention trial using a step-through passive avoidance task in mice. This deteriorating effect of 4-methylhistamine (3 micrograms/head) was clearly antagonized by pretreatment with zolantidine (10 mg/kg, i.p.), a histamine H2 receptor antagonist, 20 min before an acquisition trial. Zolantidine alone at the dose tested had no effect. Thus, it is likely that activation of histamine H2 receptors has a deteriorating effect on avoidance learning in mice. The present results indicate the cognitive involvement by negative modulation of histamine H2 receptors in passive avoidance task in mice.
Onodera
K
K
Department of Pharmacology, Tohoku University School of Dentistry, Sendai, Japan.
Miyazaki
S
S
Imaizumi
M
M
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D052160:Benzothiazoles; D003071:Cognition / Q000187:drug effects* / Q000502:physiology*; D004347:Drug Interactions; D017442:Histamine Agonists / Q000494:pharmacology; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D008568:Memory / Q000187:drug effects; D008761:Methylhistamines / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051379:Mice; D008813:Mice, Inbred ICR; D050198:Phenoxypropanolamines; D010880:Piperidines / Q000494:pharmacology; D011970:Receptors, Histamine H2 / Q000187:drug effects* / Q000502:physiology*; D013844:Thiazoles / Q000494:pharmacology
D052160:Benzothiazoles; D017442:Histamine Agonists; D006635:Histamine H2 Antagonists; D008761:Methylhistamines; D050198:Phenoxypropanolamines; D010880:Piperidines; D011970:Receptors, Histamine H2; D013844:Thiazoles; C025566:4-methylhistamine; C055302:zolantidine