Hepatitis C virus infection and mutations of mannose-binding lectin gene MBL.
We assessed the genetic polymorphism of mannose-binding lectin (MBL) in 93 patients with chronic hepatitis C (45 responders and 48 nonresponders to interferon) and 218 healthy controls. Mutant allele was identified only at codon 54 (Gly-->Asp), leading to three genotypes (54 m/m, 54 W/m, and 54 W/W). Frequency of 54 m/m was significantly lower in interferon-responders (2.2%), compared to those in nonresponders (14.6%) and controls (10.6%): p < 0.05. Our results suggest that homozygous carriage of the variant allele of codon 54 of MBL may predict poor response to interferon in chronic hepatitis C patients.
Matsushita
M
M
Department of Medical Sciences, Toshiba General Hospital, Tokyo, Japan.
Hijikata
M
M
Ohta
Y
Y
Iwata
K
K
Matsumoto
M
M
Nakao
K
K
Kanai
K
K
Yoshida
N
N
Baba
K
K
Mishiro
S
S
D000328:Adult; D000483:Alleles; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D037222:Collectins; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D019698:Hepatitis C, Chronic / Q000188:drug therapy / Q000235:genetics*; D006801:Humans; D007372:Interferons / Q000627:therapeutic use; D007564:Japan; D009154:Mutation; D017354:Point Mutation
D002352:Carrier Proteins; D037222:Collectins; D007372:Interferons