title: Beta-actin immunoreactivity in rat microglial cells: developmental pattern and participation in microglial reaction after kainate injury.
abstract: In the present study we investigated the developmental and post-injury pattern of beta-actin immunoreactivity in rat brain. Our data suggest that beta-actin is higher in microglia-macrophages than in any other central nervous system cell type, including neurons and astrocytes. We also show that beta-actin immunoreactivity is particularly high in ameboid-macrophagic cells, suggesting a role on the plastic changes that these cells experience during maturation or after activation.
authors.affiliation: Université René Descartes (Paris V) and INSERM U29, France.
authors.forename: M
authors.initials: M
authors.lastname: Plantier
authors.forename: E
authors.initials: E
authors.lastname: Der Terrossian
authors.forename: A
authors.initials: A
authors.lastname: Represa
mesh_terms: D000199:Actins / Q000276:immunology / Q000378:metabolism*; D000818:Animals; D000911:Antibodies, Monoclonal / Q000032:analysis; D001930:Brain Injuries / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D007150:Immunohistochemistry; D007608:Kainic Acid / Q000633:toxicity*; D008297:Male; D017628:Microglia / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000199:Actins; D000911:Antibodies, Monoclonal; D007608:Kainic Acid