title: Combined evaluation of rest-redistribution thallium-201 tomography and low-dose dobutamine echocardiography enhances the identification of viable myocardium in patients with chronic coronary artery disease.
abstract: The purpose of this study was to evaluate whether combined evaluation by discriminant analysis of rest-redistribution thallium-201 tomography and low-dose dobutamine echocardiography enhances the accuracy in identifying viable myocardium in patients with chronic coronary artery disease. Rest-redistribution 201Tl has high sensitivity but low specificity in identifying viable myocardium, while the opposite is true for low-dose dobutamine echocardiography. Forty-six patients underwent low-dose dobutamine echocardiography and rest-redistribution 201Tl tomography on the same day. Rest echocardiography was repeated at least 30 days (mean 40+/-20) after myocardial revascularization. Discriminant analysis was applied to the results of 201Tl tomography and dobutamine echocardiography to classify a/dyskinetic segments as viable or non-viable. In 92 a/dyskinetic segments that were revascularized, rest-redistribution 201Tl tomography yielded an accuracy of 75%, while the accuracy of dobutamine echocardiography was 70% (P<0.05). When discriminant analysis was used, the combined evaluation gave an accuracy of 83% (P<0.05 vs both tests). These findings demonstrate that low-dose dobutamine echocardiography and 201Tl imaging are useful and complementary techniques for identifying viable myocardium in patients with chronic coronary artery disease. Combined evaluation by discriminant analysis significantly improves accuracy, although the cost-effectiveness of such an approach remains to be determined.
authors.affiliation: Cattedra di Medicina Nucleare, Istituto di Scienze Radiologiche, Facoltà di Medicina, Università "Federico II", Napoli, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Pace
authors.forename: P
authors.initials: P
authors.lastname: Perrone-Filardi
authors.forename: P
authors.initials: P
authors.lastname: Mainenti
authors.forename: M
authors.initials: M
authors.lastname: Prastaro
authors.forename: P
authors.initials: P
authors.lastname: Vezzuto
authors.forename: A
authors.initials: A
authors.lastname: Varrone
authors.forename: T
authors.initials: T
authors.lastname: Crisci
authors.forename: A
authors.initials: A
authors.lastname: Cuocolo
authors.forename: S
authors.initials: S
authors.lastname: Dellegrottaglie
authors.forename: F
authors.initials: F
authors.lastname: Piscione
authors.forename: M
authors.initials: M
authors.lastname: Chiariello
authors.forename: M
authors.initials: M
authors.lastname: Salvatore
mesh_terms: D000318:Adrenergic beta-Agonists; D000328:Adult; D000368:Aged; D003327:Coronary Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology; D004280:Dobutamine; D004452:Echocardiography; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization; D011877:Radionuclide Imaging; D012044:Regression Analysis; D013318:Stroke Volume; D013794:Thallium Radioisotopes
chemical_list: D000318:Adrenergic beta-Agonists; D013794:Thallium Radioisotopes; D004280:Dobutamine