Sympathetic activation triggers systemic interleukin-10 release in immunodepression induced by brain injury.
The mechanism of immunodepression after brain injury is not yet clear. Here we demonstrate rapid systemic release of the immunoinhibitory cytokine interleukin-10, monocytic deactivation and a high incidence of infection in patients with 'sympathetic storm' due to acute accidental or iatrogenic brain trauma. In vitro studies showed that within minutes catecholamines trigger the secretion of interleukin-10 from unstimulated monocytes through a beta-adrenoreceptor-mediated, cAMP/protein kinase A-dependent pathway. We found that in a rat model of acute brain injury, the beta-receptor antagonist propranolol prevented the increase of interleukin-10 plasma levels. Rapid monocytic interleukin-10 release after sympathetic activation may represent a common pathway for immunodepression induced by stress and injury.
Woiciechowsky
C
C
Department of Neurosurgery, Medical School Charité, Humboldt University, Berlin, Germany.
Asadullah
K
K
Nestler
D
D
Eberhardt
B
B
Platzer
C
C
Schöning
B
B
Glöckner
F
F
Lanksch
W R
WR
Volk
H D
HD
Döcke
W D
WD
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000328:Adult; D000368:Aged; D000818:Animals; D001921:Brain / Q000601:surgery; D001930:Brain Injuries / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D001932:Brain Neoplasms / Q000097:blood / Q000601:surgery; D001933:Brain Stem / Q000503:physiopathology; D002395:Catecholamines / Q000494:pharmacology; D006801:Humans; D007108:Immune Tolerance; D016753:Interleukin-10 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009380:Neoplasms, Nerve Tissue / Q000097:blood / Q000601:surgery; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000503:physiopathology*; D013565:Sympatholytics / Q000494:pharmacology; D013566:Sympathomimetics / Q000494:pharmacology
D000319:Adrenergic beta-Antagonists; D002395:Catecholamines; D013565:Sympatholytics; D013566:Sympathomimetics; D016753:Interleukin-10; D011433:Propranolol