title: Clinicopathological features of early gastric cancer in younger versus older patients in a high incidence area of northern Italy.
abstract: OBJECTIVE
  The relationship between the clinicopathological features of early gastric cancer and age were analysed in a retrospective study of 168 patients.
  
  
  METHODS
  168 patients, residents of the Region of Cremona, who had undergone surgery in the period 1978 to 1990 for early gastric cancer, were divided into two groups by age and compared. Group I (n = 89) consisted of patients less than 65 years of age and Group II (n = 79) of patients between 66 and 85 years of age.
  
  
  RESULTS
  There were no significant differences between the two groups with respect to the sex ratio, tumour size, depth of tumour invasion, and 5-year survival rate. Group I patients showed more lymph node involvement (p < 0.01), cancer of the diffuse histological type (p < 0.01), and cancers located in the gastric body (p < 0.05). Conversely, Group II exhibited more cancers of the protruded (p < 0.05) and intestinal histological type (p < 0.01), and more adenomatous residue (p < 0.01).
  
  
  CONCLUSIONS
  Our findings suggest that early gastric cancer may present differently in different age groups; persons 65 years of age and older are more likely to have early gastric cancer of the slow-growing type than middle-aged patients.
authors.affiliation: Department of Human Pathology, University of Messina, Italy.
authors.forename: R A
authors.initials: RA
authors.lastname: Caruso
authors.forename: G
authors.initials: G
authors.lastname: Finocchiaro
authors.forename: A
authors.initials: A
authors.lastname: Bersiga
authors.forename: F
authors.initials: F
authors.lastname: Fedele
authors.forename: E
authors.initials: E
authors.lastname: Betri
authors.forename: L
authors.initials: L
authors.lastname: Rigoli
authors.forename: C
authors.initials: C
authors.lastname: Inferrera
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000503:physiopathology; D015996:Survival Rate