Alpha-fetoprotein producing pulmonary blastoma in a patient with systemic sclerosis: pathogenetic analysis.
We describe a rare case of pulmonary blastoma complicated with systemic sclerosis. The serum alpha-fetoprotein level was elevated at presentation and the biopsied tumour stained positively against anti-alpha-fetoprotein antibody. The alpha-fetoprotein produced autonomously by tumour cells was of yolk-sac origin. Although the pathogenesis of pulmonary blastoma has not been clarified, we suggest that this pulmonary blastoma is a type of yolk-sac tumour.
Kasuga
I
I
First Dept of Internal Medicine, Tokyo Medical College Hospital, Japan.
Miyamoto
D
D
Ichinose
Y
Y
Chimangul
W
W
Minemura
K
K
Utsumi
K
K
Yonemaru
M
M
Serizawa
H
H
Ebihara
Y
Y
Toyama
K
K
D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008175:Lung Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism*; D008875:Middle Aged; D018202:Pulmonary Blastoma / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism*; D013902:Radiography, Thoracic; D012595:Scleroderma, Systemic / Q000150:complications*; D014057:Tomography, X-Ray Computed; D000509:alpha-Fetoproteins / Q000096:biosynthesis*
D000509:alpha-Fetoproteins