title: Dynamic assessment of parathyroid function in acute malaria.
abstract: OBJECTIVE
  To investigate the dynamic parathyroid response to rapidly induced, sustained hypocalcaemia in patients with acute malaria and in healthy volunteers.
  
  
  METHODS
  Serum intact parathormone (PTH) concentrations were measured on samples taken before and during a variable-rate tri-sodium citrate infusion designed to 'clamp' the whole blood ionised calcium concentration 0.20 mmol L-1 below baseline for 120 min.
  
  
  METHODS
  Six Malaysian patients aged 17-42 years with acute malaria, four of whom were restudied in convalescence, and 12 healthy controls aged 19-36 years.
  
  
  METHODS
  Whole-blood ionised calcium and serum intact PTH concentrations.
  
  
  RESULTS
  The mean (SD baseline ionised calcium was lower in the malaria patients than in controls (1.09 +/- 0.06 vs. 1.18 +/- 0.03 mmol L-1, respectively; P = 0.01) but PTH concentrations were similar (3.0 +/- 1.8 vs. 3.3 +/- 1.3 pmol L(-1); P = 0.33). Target whole-blood ionised calcium concentrations were achieved more rapidly in the controls than the patients (within 15 vs. 30 min) despite significantly more citrate being required in the patients (area under the citrate infusion-time curve 0.95 (0.25 vs. 0.57 +/- 0.09 mmol kg-1; P < 0.01). The ratio of the change in serum PTH to that in ionised calcium (delta PTH/ delta Ca2+), calculated to adjust for differences in initial rate of fall of ionised calcium, was similar during the first 5 min of the clamp (132 +/- 75 x 10(-6) vs. 131 +/- 43 x 10(-6) in patients and controls, respectively, P > 0.05), as were steady-state serum PTH levels during the second hour (7.0 +/- 2.2 pmol L-1 in each case). Convalescent patients had normal basal ionised calcium levels but the lowest serum intact PTH levels before and during the clamp, consistent with an increase in skeletal PTH sensitivity after treatment.
  
  
  CONCLUSIONS
  There is a decreased ionised calcium 'set point' for basal PTH secretion but a normal PTH response to acute hypocalcaemia in malaria. Skeletal resistance may attenuate the effects of the PTH response but patients with malaria appear relatively resistant to the calcium chelating effects of citrated blood products.
authors.affiliation: University of Western Australia, Department of Medicine, Fremantle Hospital, Australia.
authors.forename: T M
authors.initials: TM
authors.lastname: Davis
authors.forename: B
authors.initials: B
authors.lastname: Singh
authors.forename: K E
authors.initials: KE
authors.lastname: Choo
authors.forename: J
authors.initials: J
authors.lastname: Ibrahim
authors.forename: S A
authors.initials: SA
authors.lastname: Sulaiman
authors.forename: Z A
authors.initials: ZA
authors.lastname: Kadir
authors.forename: R
authors.initials: R
authors.lastname: Ismail
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D002118:Calcium / Q000097:blood*; D019355:Calcium Citrate; D016022:Case-Control Studies; D002614:Chelating Agents; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008288:Malaria / Q000097:blood* / Q000503:physiopathology; D016778:Malaria, Falciparum / Q000097:blood; D016780:Malaria, Vivax / Q000097:blood; D008297:Male; D010280:Parathyroid Glands / Q000187:drug effects / Q000503:physiopathology*; D010281:Parathyroid Hormone / Q000097:blood*; D013997:Time Factors
chemical_list: D002614:Chelating Agents; D010281:Parathyroid Hormone; D019355:Calcium Citrate; D002118:Calcium