Intact autocrine activation and cytokine production by PMNs from injured adults with elevated Candida antigen titres.
Injured patients with Candida antigen titres have increased mortality due to sepsis. Polymorphonuclear leucocytes (PMNs) from injured patients with elevated Candida antigen titres demonstrate impaired function against Candida albicans growth when compared with PMNs from injury matched controls. To determine if PMN dysfunction is global, PMNs from patients with positive Candida antigen titres were evaluated for their ability to activate the anticandidal function of normal PMNs (autocrine activation) and to produce tumour necrosis factor (TNF) and interleukin 8 (IL8), known activators of PMN anticandidal function, this study demonstrates that the PMN dysfunction is not global, as PMN cytokine production and autocrine activation remain intact.
Sweeney
J F
JF
Department of Surgery and Medical Microbiology and Immunology, University of South Florida College of Medicine, USA.
Rosemurgy
A S
AS
Wei
S
S
Djeu
J Y
JY
D000328:Adult; D000946:Antigens, Fungal / Q000097:blood*; D019898:Autocrine Communication; D002176:Candida albicans / Q000276:immunology*; D002478:Cells, Cultured; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000378:metabolism; D008297:Male; D009181:Mycoses / Q000276:immunology; D009504:Neutrophils / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D014949:Wounds, Nonpenetrating / Q000276:immunology* / Q000382:microbiology
D000946:Antigens, Fungal; D016207:Cytokines; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha