title: Efficacy of moxidectin 2% oral gel against second- and third-instar Gasterophilus intestinalis De Geer.
abstract: In a trial designed to evaluate the efficacy of the recommended dosage of moxidectin 2% oral gel against the gastric stages of Gasterophilus spp., 14 ponies were selected from a herd on the basis of the inclusion criterion of the presence of Gasterophilus spp. eggs attached to their hair coats. After random allocation, the ponies were treated with 1 of 2 treatments, moxidectin 2% equine gel in a single dose at the commercial dosage of 400 microg moxidectin/kg body weight or placebo gel. The animals were necropsied 14 days posttreatment. Efficacies against second- and third-instar Gasterophilus intestinalis De Geer were 100% and 99.5%, respectively.
authors.affiliation: Fort Dodge Animal Health, Princeton, New Jersey 08543-0400, USA.
authors.forename: P J
authors.initials: PJ
authors.lastname: Scholl
authors.forename: M R
authors.initials: MR
authors.lastname: Chapman
authors.forename: D D
authors.initials: DD
authors.lastname: French
authors.forename: T R
authors.initials: TR
authors.lastname: Klei
mesh_terms: D000284:Administration, Oral; D000704:Analysis of Variance; D000818:Animals; D000900:Anti-Bacterial Agents; D004175:Diptera; D005260:Female; D005782:Gels; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D007306:Insecticides / Q000008:administration & dosage / Q000627:therapeutic use*; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000662:veterinary*; D007814:Larva; D018942:Macrolides / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D013270:Stomach / Q000469:parasitology*
chemical_list: D000900:Anti-Bacterial Agents; D005782:Gels; D007306:Insecticides; D018942:Macrolides; C027837:moxidectin