title: Prostate cancer: local staging with endorectal magnetic resonance imaging.
abstract: BACKGROUND
  Prostate cancer has received increasing attention during the past decades. Staging of tumors before treatment is imperative for planning appropriate therapy. The purpose of this study is to assess the role of endorectal magnetic resonance imaging (MRI) in local staging of prostate cancer.
  
  
  METHODS
  Endorectal MRI was performed in 31 patients with histologically-proven prostate cancer. MRI was done three to 100 days (mean, 32.1 days) after either transrectal ultrasonography (TRUS) with biopsy or transurethral resection of the prostate (TURP). Radical prostatectomies were performed within two weeks after MRI. The diagnostic accuracy of endorectal MRI for local tumor staging, specifically for extracapsular extension (ECE) and seminal vesicle invasion (SVI), was evaluated by correlating MRI results with histopathologic findings of whole-mount specimens.
  
  
  RESULTS
  The accuracy of endorectal MRI for the detection of tumor presence and estimation of tumor volume was 48%. Sensitivity, specificity and positive predictive value for evaluation of ECE were 88%, 69% and 80%, respectively, and for SVI, were 66%, 84% and 50%, respectively. The overall accuracy of MRI in local tumor staging (using the TMN system) was 61%. Accuracy in differentiating localized from invasive cancer was 84%.
  
  
  CONCLUSIONS
  Endorectal MRI is not accurate enough to detect tumor presence or estimate tumor volume. Diagnostic accuracy for local tumor staging is unsatisfactory. However, endorectal MRI is highly accurate in differentiating localized (stage B) from invasive (stage C) cancer.
authors.affiliation: Department of Radiology, Veterans General Hospital-Taipei, Taiwan, ROC.
authors.forename: M H
authors.initials: MH
authors.lastname: Sheu
authors.forename: J H
authors.initials: JH
authors.lastname: Wang
authors.forename: K K
authors.initials: KK
authors.lastname: Chen
authors.forename: H
authors.initials: H
authors.lastname: Chiang
authors.forename: M H
authors.initials: MH
authors.lastname: Teng
mesh_terms: D000368:Aged; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000473:pathology*; D012007:Rectum