[Overexpression of p53 protein in epidermoid carcinoma of the pyriform sinus].
Mutation of the p53 protein may be the commonest genetic event in the development of malignant neoplasms in humans. We analyzed the immunohistological expression of p53 in tissue sections from 51 patients with squamous cell carcinoma of the pyriform sinus who were treated with surgery and postoperative radiotherapy. Overexpression of p53 was found in 37 (72.5%) tumors. No correlation was found between p53 overexpression and clinical and histopathological parameters. Recurrence and overall survival did not differ between p53-positive and p53-negative cases.
del Valle Zapico
A
A
Servicio de ORL, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria.
Fernández Fernández
F
F
Mayorga Fernández
M
M
Rubio Suárez
A
A
Morales Angulo
C
C
Rama Quintela
J
J
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000401:mortality; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000401:mortality; D008875:Middle Aged; D017354:Point Mutation; D012189:Retrospective Studies; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
D016159:Tumor Suppressor Protein p53
Sobreexpresión de la proteína p53 en el carcinoma epidermoide de seno piriforme.