Synthesis of some indane derivatives of central muscle relaxant and anticonvulsant profiles.
A series of 2,2-bis(hydroxymethyl)indane derivatives 1a-f, 2a-e and 3a-f were synthesized to investigate their central muscle relaxant and anticonvulsant activities. The synthesized compounds 1a-f, 2a-e and 3a-f were found to be devoid of central muscle relaxant activity using meprobamate (100 mg/kg) as a reference standard. However, they showed remarkable anticonvulsant properties in a dose of 80 mg/kg (s.c.) compared with diphenylhydantoin sodium (80 mg/kg) as a reference standard.
Abdallah
N A
NA
Department of Pharmaceutical Sciences, National Research Centre, Dokki, Cairo, Egypt.
el-Shabrawy
O
O
el-Eraky
W
W
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D007189:Indans / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D015394:Molecular Structure; D009125:Muscle Relaxants, Central / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
D000927:Anticonvulsants; D007189:Indans; D009125:Muscle Relaxants, Central