Regulation of the type II oncostatin M receptor expression in lung-derived epithelial cells.
Oncostatin M (OSM) is a potent modulator of human lung-derived epithelial cell function. This cytokine binds two distinct receptor complexes: type I OSM receptor which is also a functional receptor for leukemia inhibitory factor (LIF), and type II OSM-specific receptor. The role of these two distinct receptors in mediating the response of individual cell types to OSM has not been delineated. In contrast to LIF, OSM induces synthesis of alpha1-antichymotrypsin and alpha1-antiproteinase inhibitor in lung-derived epithelial cells. The differential responsiveness to LIF and OSM suggested that the response of lung epithelial cells to OSM may be mediated by the OSM-specific receptor. Therefore, we characterized lung-derived epithelial cells for the expression of type II OSM receptor mRNAs, and the regulation of the mRNAs encoding the components of the OSM-specific receptor by cytokines and dexamethasone.
Cichy
J
J
Department of Microbiology and Immunology, Institute of Molecular Biology, Jagiellonian University, Cracow, Poland. JCichy@wista.wistar.upenn.edu
Rose-John
S
S
Puré
E
E
D015703:Antigens, CD / Q000096:biosynthesis; D001980:Bronchi / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D050822:Cytokine Receptor gp130; D016207:Cytokines / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism*; D005786:Gene Expression Regulation; D006131:Growth Inhibitors / Q000494:pharmacology; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D015850:Interleukin-6; D053605:Leukemia Inhibitory Factor; D008168:Lung / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D008222:Lymphokines / Q000494:pharmacology; D008562:Membrane Glycoproteins / Q000096:biosynthesis; D053683:Oncostatin M; D010455:Peptides / Q000378:metabolism*; D018121:Receptors, Cytokine / Q000096:biosynthesis*; D053677:Receptors, Oncostatin M; D012137:Respiratory System / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*
D015703:Antigens, CD; D016207:Cytokines; D006131:Growth Inhibitors; C494199:IL6ST protein, human; D018836:Inflammation Mediators; D015850:Interleukin-6; C507837:LIF protein, human; D053605:Leukemia Inhibitory Factor; D008222:Lymphokines; D008562:Membrane Glycoproteins; C508351:OSM protein, human; D010455:Peptides; D018121:Receptors, Cytokine; D053677:Receptors, Oncostatin M; D053683:Oncostatin M; D050822:Cytokine Receptor gp130; D003907:Dexamethasone