title: Viral determinants of rotavirus pathogenicity in pigs: evidence that the fourth gene of a porcine rotavirus confers diarrhea in the homologous host.
abstract: A porcine rotavirus (prv) monoreassortant, S-F4, which carries RNA segment 4 of the pig-pathogenic variant prv 4F in the genetic background of the pig-apathogenic variant prv 4S (G. I. Tauscher and U. Desselberger, J. Virol. 71:853-857, 1997), was found to be pathogenic in gnotobiotic piglets. This indicates that RNA segment 4 of the pig-pathogenic variant prv 4F is a major determinant of pathogenicity in its homologous host.
authors.affiliation: Department of Pathology and Infectious Diseases, The Royal Veterinary College, University of London, London NW1 0TU, United Kingdom. jbridger@rvc.ac.uk
authors.forename: J C
authors.initials: JC
authors.lastname: Bridger
authors.forename: G I
authors.initials: GI
authors.lastname: Tauscher
authors.forename: U
authors.initials: U
authors.lastname: Desselberger
mesh_terms: D000818:Animals; D003967:Diarrhea / Q000662:veterinary* / Q000821:virology; D012367:RNA, Viral; D012401:Rotavirus / Q000235:genetics*; D013552:Swine; D013553:Swine Diseases / Q000821:virology*
chemical_list: D012367:RNA, Viral