[Studies on penetration of cefepime into respiratory tract using broncho-alveolar lavage and sputum].
We investigated broncho-alveolar distribution of cefepime (CFPM), a fourth generation cephem, using 38 BALF specimens from 19 serious pneumonia patients who underwent artificial respiratory system control. The mean broncho-alveolar CFPM level was 3.44 microgram/ml (5.34% of the mean peak blood level). We thus observed that the BALF level after a single dose of 1 g of CFPM exceeds the MIC90 of the drug against RTI causing bacteria such as Streptococcus pneumoniae, Klebsiella pneumoniae, Haemophillus influenzae, Branhamella catarrhalis, coagulase-negative Staphylococcus, Pseudomonas aeruginosa and Staphylococcus aureus.
Arai
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C
Department of Emergency Medicine, Tokyo Women's Medical College, Japan.
Suzuki
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T
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D000077723:Cefepime; D002511:Cephalosporins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000188:drug therapy; D012137:Respiratory System / Q000378:metabolism*; D013183:Sputum / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D000077723:Cefepime