title: Prevention of hypoglycaemia in a patient with type Ib glycogen storage disease by an amylase (alpha-glucosidase) inhibitor.
abstract: Patients with type Ib glycogen storage disease (GSD Ib) are susceptible to hypoglycaemic episodes. To determine whether an amylase (alpha-glucosidase) inhibitor, voglibose, can be useful in the control of hypoglycaemia, we tried it in a 14-y-old male with GSD Ib. Oral administration of voglibose prolonged the duration of normoglycaemia and reduced the incidence of hypoglycaemia attacks. These findings indicate that voglibose may be useful for preventing hypoglycaemia in GSD Ib patients.
authors.affiliation: Department of Paediatrics, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ihara
authors.forename: R
authors.initials: R
authors.lastname: Kuromaru
authors.forename: A
authors.initials: A
authors.lastname: Ryu
authors.forename: J
authors.initials: J
authors.lastname: Fukushige
authors.forename: T
authors.initials: T
authors.lastname: Hara
mesh_terms: D000293:Adolescent; D001786:Blood Glucose; D005953:Glycogen Storage Disease Type I / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D065089:Glycoside Hydrolase Inhibitors; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology / Q000517:prevention & control*; D007294:Inositol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male
chemical_list: D001786:Blood Glucose; D065089:Glycoside Hydrolase Inhibitors; D007294:Inositol; C102817:voglibose