Association study between the -141C Ins/Del and TaqI A polymorphisms of the dopamine D2 receptor gene and alcoholism.
Dopamine D2 receptors have been implicated in the biology of alcohol preference. We examined the -141 C Ins/Del polymorphism in the promoter region of the dopamine D2 receptor gene (DRD2) and the DRD2 TaqI A polymorphisms in 209 Japanese alcoholics and 152 age- and sex-matched Japanese controls. The Ins allele was significantly increased in the alcoholics, compared with the controls (p < 0.002, odds ratio = 1.82). The TaqI A1 allele tended to be more frequent in the alcoholics than in the controls (p < 0.04). Linkage disequilibrium between these two polymorphisms was weak (a maximum delta value = 0.13). The -141 C Ins/Del polymorphism may affect the vulnerability for alcoholism presumably through different expression of DRD2 in the Japanese.
Ishiguro
H
H
Department of Neuropsychiatry, Tokyo Medical and Dental University School of Medicine, Japan.
Arinami
T
T
Saito
T
T
Akazawa
S
S
Enomoto
M
M
Mitushio
H
H
Fujishiro
H
H
Tada
K
K
Akimoto
Y
Y
Mifune
H
H
Shioduka
S
S
Hamaguchi
H
H
Toru
M
M
Shibuya
H
H
D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000235:genetics*; D000483:Alleles; D002872:Chromosome Deletion; D004251:DNA Transposable Elements / Q000235:genetics*; D005260:Female; D015870:Gene Expression / Q000502:physiology; D005787:Gene Frequency / Q000235:genetics; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D019914:Taq Polymerase / Q000235:genetics*
D004251:DNA Transposable Elements; D017448:Receptors, Dopamine D2; D019914:Taq Polymerase