Liver bilirubin UDP-glucuronosyltransferase activity in chronic nonhemolytic unconjugated hyperbilirubinemia of adults.
Ten adult patients with chronic nonhemolytic unconjugated (indirect) hyperbilirubinemia were analyzed by determining bilirubin uridine diphosphate-glucuronosyltransferase activity according to a more physiological and sensitive method (9 control cases, 0.457 +/- 0.163 nmole/mg protein/min). There was no overlap of the enzyme activities of 2 cases with Crigler-Najjar syndrome (type II) (0.006 nmole/mg protein/min on average) and 6 cases with Gilbert's syndrome (0.051 +/- 0.016 nmole/mg protein/min). The enzyme activities in 2 patients with post-hepatitic hyperbilirubinemia were within the normal range. A new classification of nonhemolytic unconjugated hyperbilirubinemia in adults is proposed according to the results of this enzyme activity and the recent data on the gene mutation of this enzyme.
Watanabe
A
A
Third Department of Internal Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Wakabayashi
H
H
Kuwabara
Y
Y
Yamamoto
H
H
Hattori
S
S
Tsuji
T
T
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002908:Chronic Disease; D003414:Crigler-Najjar Syndrome / Q000145:classification / Q000201:enzymology / Q000235:genetics; D005260:Female; D005878:Gilbert Disease / Q000145:classification / Q000201:enzymology / Q000235:genetics; D014453:Glucuronosyltransferase / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D006932:Hyperbilirubinemia / Q000145:classification / Q000201:enzymology* / Q000235:genetics; D007565:Jaundice / Q000201:enzymology / Q000209:etiology; D008099:Liver / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D009154:Mutation
C019787:bilirubin glucuronoside glucuronosyltransferase; D014453:Glucuronosyltransferase