Retrospective analysis of birth weight and prostate cancer in the Health Professionals Follow-up Study.
The authors retrospectively evaluated the relation between birth weight and prostate cancer (1986-1994) among 21,140 men of the Health Professionals Follow-up Study who reported in 1994 their weight at birth. No relation between birth weight and prostate cancer (n=545) was observed in multivariate logistic models. For high stage/grade tumors (n=213), compared with birth weights <7.0 lbs (<3,175 g), the relative risks were 1.20 (95% confidence interval (CI) 0.79-1.83) for 8.5-9.9 lbs (3,855.6-4,490.6 g) and 1.30 (95% CI 0.80-2.10) for > or = 10 lbs (> or = 4,536 g). These findings do not support an overall association between birth weight and prostate cancer incidence, but the possibility of a modest positive association between birth weight and high stage/grade prostatic cancer cannot be excluded.
Platz
E A
EA
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.
Giovannucci
E
E
Rimm
E B
EB
Curhan
G C
GC
Spiegelman
D
D
Colditz
G A
GA
Willett
W C
WC
D000328:Adult; D000368:Aged; D001724:Birth Weight; D015331:Cohort Studies; D006282:Health Personnel; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000473:pathology