Effects of ethanol on temporal recovery of auditory-evoked potentials in individuals at risk for alcoholism.
The present investigation examined the effects of placebo (P), low dose (LD), and high dose (HD) ethanol on auditory event-related potential (AEP) recovery functions in a group of males at high risk to develop alcoholism (HR; n = 23, mean = 22.3 years) and a low risk (LR; n = 27, mean = 23.0 years) control group. Condition order was randomized, with one condition (P, LD, or HD) per day and a minimum 1-day interval between conditions. For each subject, both blood alcohol levels (BALs) measured via breathalyzer, and event-related potentials recorded with the entire 10/20 International System, were assessed prior to and at mean intervals of 20, 60, 90, and 130 min after P, LD, or HD administration. A series of binaural auditory stimuli with randomly interposed interstimulus intervals of 0.5, 1.0, and 10.0 sec were used to elicit the N100 and P200 components of the AEP. Between-groups comparisons indicated that ethanol elicited risk group differences in recovery functions not present at baseline. The differences were manifested in the HR group as larger decrements in P200 amplitude during the ascending blood alcohol curve (acute sensitivity) and more rapid returns of both N100 and P200 to baseline levels during the descending blood alcohol curve (acute tolerance). These findings support Newlin and Thomson's (1990) Differentiator Model, suggesting that LR and HR individuals are differentially sensitive to the effects of ethanol.
Cohen
H L
HL
Department of Psychiatry, SUNY Health Science Center-Brooklyn, New York 11203, USA.
Porjesz
B
B
Stimus
A T
AT
Begleiter
H
H
D000293:Adolescent; D000328:Adult; D000437:Alcoholism / Q000097:blood / Q000235:genetics*; D001143:Arousal / Q000187:drug effects / Q000235:genetics; D016241:Child of Impaired Parents; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000493:pharmacokinetics / Q000494:pharmacology*; D005072:Evoked Potentials, Auditory / Q000187:drug effects / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D011930:Reaction Time / Q000187:drug effects / Q000235:genetics*; D012307:Risk Factors
D000431:Ethanol