title: Fatal cerebral oedema associated with primary dengue infection.
abstract: Encephalopathy associated with dengue fever is considered to be a rare condition in adults. We describe a patient with a primary dengue infection who, in the absence of overt signs of dengue shock syndrome, died due to progressive cerebral oedema. Autopsy findings demonstrated loss of integrity of cerebral vascular endothelium and involvement of complement activation.
authors.affiliation: Department of Internal Medicine, Westeinde Hospital, The Hague, The Netherlands.
authors.forename: H L
authors.initials: HL
authors.lastname: Janssen
authors.forename: H P
authors.initials: HP
authors.lastname: Bienfait
authors.forename: C L
authors.initials: CL
authors.lastname: Jansen
authors.forename: S G
authors.initials: SG
authors.lastname: van Duinen
authors.forename: R
authors.initials: R
authors.lastname: Vriesendorp
authors.forename: R J
authors.initials: RJ
authors.lastname: Schimsheimer
authors.forename: J
authors.initials: J
authors.lastname: Groen
authors.forename: A D
authors.initials: AD
authors.lastname: Osterhaus
mesh_terms: D000328:Adult; D001929:Brain Edema / Q000209:etiology / Q000821:virology*; D003715:Dengue / Q000150:complications*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D014057:Tomography, X-Ray Computed