The physics of transmyocardial laser revascularization.
Lasers create channels through the myocardium by ablating the tissue and tissue ablation is achieved by breaking the molecular bonds of the organic constituents of the myocardium. Lasers provide the energy required to dissociate these molecular bonds by the interaction of laser photons with the tissue. However, the energy supplied to the electrons within the bonds must match specific allowed energy levels. Such energy matching is accomplished through different mechanisms by different laser wavelengths. Infrared laser photons are strongly absorbed by water in the tissue and it is the subsequent vaporization of the water that provides the energy necessary to break the bonds. In contrast, ultraviolet laser photons are not absorbed by water and have energies that can match those required for bond dissociation. Thus, ablation by ultraviolet lasers is achieved primarily by direct bond absorption of the photons. Both of these ablation mechanisms produce secondary effects that can cause injury to tissue surrounding the channels. The generation of steam or the gaseous breakdown products of tissue proteins can cause thermal injury in addition to the mechanical injury produced by escape of these gases into the tissue. Furthermore, shock waves generated by ablation are also a possible source of mechanical injury, while free radical molecules capable of cell injury are known to be formed after breaking chemical bonds. The variety of tissue interactions provided by the different lasers should enable the optimal laser treatment to be applied once the optimal channel configuration has been determined.
Hartman
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AccuLase, Inc., San Diego, California 92121, USA.
Whittaker
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D055592:Biophysical Phenomena; D001703:Biophysics; D002245:Carbon Dioxide; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006335:Heart Injuries / Q000209:etiology; D006695:Holmium; D006358:Hot Temperature; D006801:Humans; D007259:Infrared Rays; D053685:Laser Therapy / Q000009:adverse effects; D015394:Molecular Structure; D009204:Myocardial Revascularization / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods*; D009206:Myocardium / Q000737:chemistry*; D017785:Photons; D014466:Ultraviolet Rays; D014867:Water / Q000737:chemistry
D014867:Water; D002245:Carbon Dioxide; D006695:Holmium