The location of a specific epitope in the SU proteins of palysis-inducing PVC murine leukemia viruses.
The location of a specific epitope in the SU proteins (gp70s) of PVC (PVC-111, PVC-211, PVC-321 and PVC-441) murine leukemia viruses (MuLVs) among various MuLVs was determined with chimeric viruses between PVC-211 and F-MuLV and a rat monoclonal antibody to the gp70 of PVC-321. The epitope resided in the N-terminal region from amino acid position 1 to 67 of SU protein and did not correlate to the tropism against brain capillary endothelial cells of the F344 rat or Chinese hamster ovary cells.
Kai
K
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Department of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, Japan.
D000595:Amino Acid Sequence; D000818:Animals; D000911:Antibodies, Monoclonal; D002678:Chimera; D006224:Cricetinae; D018604:Epitope Mapping; D000939:Epitopes / Q000737:chemistry; D015686:Gene Products, env / Q000737:chemistry / Q000276:immunology*; D015752:Genes, env; D015750:Genes, gag; D015751:Genes, pol; D009052:Leukemia Virus, Murine / Q000235:genetics / Q000276:immunology*; D051379:Mice; D008969:Molecular Sequence Data; D051381:Rats; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity
D000911:Antibodies, Monoclonal; D000939:Epitopes; D015686:Gene Products, env