Transcriptional control: Tat cofactors and transcriptional elongation.
HIV-1 gene expression requires the transactivator Tat, which stimulates viral transcript elongation. Recent results show that two cellular cyclin-dependent kinases, which phosphorylate the carboxy-terminal domain of the RNA polymerase II large subunit, contact Tat and contribute to the control of transcriptional elongation.
Yankulov
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Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Bentley
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D000818:Animals; D015696:Gene Products, tat / Q000502:physiology*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D010441:Peptide Chain Elongation, Translational / Q000235:genetics; D010445:Peptide Elongation Factors / Q000502:physiology; D014158:Transcription, Genetic / Q000502:physiology*; D054322:tat Gene Products, Human Immunodeficiency Virus
D015696:Gene Products, tat; D010445:Peptide Elongation Factors; D054322:tat Gene Products, Human Immunodeficiency Virus