title: Regulation of translation initiation factors by signal transduction.
abstract: Regulation of eukaryotic translation initiation is a process that requires collaboration between multiple proteins. The cap-binding factor eukaryotic initiation factor (eIF)4E, its binding protein 4E-BP1, and the guanine-nucleotide-exchange factor eIF2B play important roles in the regulation of the rate of protein synthesis. This review describes the regulation of the activity of these three proteins and the signal-transduction pathways involved therein.
authors.affiliation: Utrecht University, Department of Molecular Cell Biology, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Kleijn
authors.forename: G C
authors.initials: GC
authors.lastname: Scheper
authors.forename: H O
authors.initials: HO
authors.lastname: Voorma
authors.forename: A A
authors.initials: AA
authors.lastname: Thomas
mesh_terms: D000818:Animals; D020717:Eukaryotic Initiation Factor-2B; D039561:Eukaryotic Initiation Factor-4E; D020662:Guanine Nucleotide Exchange Factors; D006801:Humans; D010442:Peptide Chain Initiation, Translational; D010448:Peptide Initiation Factors / Q000378:metabolism*; D014176:Protein Biosynthesis; D011506:Proteins / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D020717:Eukaryotic Initiation Factor-2B; D039561:Eukaryotic Initiation Factor-4E; D020662:Guanine Nucleotide Exchange Factors; D010448:Peptide Initiation Factors; D011506:Proteins