High local production of nitric oxide as a possible mechanism by which rapamycin prevents transplant arteriosclerosis.
Pham
S M
SM
Department of Surgery, University of Pittsburgh, PA 15213, USA.
Shears
L L
LL
Kawaharada
N
N
Li
S
S
Venkataramanan
R
R
Sehgal
S
S
D000818:Animals; D001013:Aorta, Thoracic / Q000473:pathology / Q000637:transplantation*; D001161:Arteriosclerosis / Q000517:prevention & control*; D016572:Cyclosporine / Q000494:pharmacology; D004790:Enzyme Induction; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D019001:Nitric Oxide Synthase / Q000096:biosynthesis*; D052247:Nitric Oxide Synthase Type II; D011090:Polyenes / Q000494:pharmacology*; D011183:Postoperative Complications / Q000517:prevention & control; D051381:Rats; D011912:Rats, Inbred ACI; D011920:Rats, Inbred WF; D020123:Sirolimus; D014184:Transplantation, Homologous / Q000276:immunology / Q000473:pathology / Q000502:physiology*; D014185:Transplantation, Isogeneic / Q000276:immunology / Q000473:pathology / Q000502:physiology*
D007166:Immunosuppressive Agents; D011090:Polyenes; D016572:Cyclosporine; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; C496318:Nos2 protein, rat; D020123:Sirolimus