title: Platelet-derived endothelial cell growth factor/thymidine phosphorylase expression correlated with tumor angiogenesis and macrophage infiltration in colorectal cancer.
abstract: To clarify whether platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP) expression in both tumor cells and stromal cells has independent or synergistic effects on tumor angiogenesis and progression and to explore a possible regulator for PD-ECGF/TP expression, immunohistochemical staining was conducted on 148 specimens of colorectal cancer. The microvessel count was significantly correlated with the extent of PD-ECGF/TP expression. Macrophage infiltration in tumors with positive TP was significantly higher than in tumors with negative TP (P < 0.001). The Cox model showed that PD-ECGF/TP expression was an independent prognostic factor, although the microvessel count had a stronger value in determining the patient prognosis.
authors.affiliation: The Second Department of Surgery, Fukui Medical University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Matsumura
authors.forename: Y
authors.initials: Y
authors.lastname: Chiba
authors.forename: C
authors.initials: C
authors.lastname: Lu
authors.forename: H
authors.initials: H
authors.lastname: Amaya
authors.forename: T
authors.initials: T
authors.lastname: Shimomatsuya
authors.forename: T
authors.initials: T
authors.lastname: Horiuchi
authors.forename: R
authors.initials: R
authors.lastname: Muraoka
authors.forename: N
authors.initials: N
authors.lastname: Tanigawa
mesh_terms: D000230:Adenocarcinoma / Q000098:blood supply* / Q000201:enzymology* / Q000276:immunology; D000368:Aged; D015179:Colorectal Neoplasms / Q000098:blood supply* / Q000201:enzymology* / Q000276:immunology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008264:Macrophages / Q000276:immunology*; D008297:Male; D009389:Neovascularization, Pathologic; D017154:Stromal Cells / Q000201:enzymology; D013939:Thymidine Phosphorylase / Q000378:metabolism*
chemical_list: D013939:Thymidine Phosphorylase