Human IgG Fc receptors.
Human IgG receptors constitute a family of glycoprotein complexes consisting of ligand-binding, and associated signaling chains. Three leukocyte classes (Fc gamma RI, II, and III) and one separate endothelial Fc gamma R class (FcRB) are defined which are expressed on hematopoietic and endothelial cells. Upon interaction with IgG, Fc gamma R initiate a plethora of signaling cascades involving receptor signaling motifs, and protein tyrosine kinases and phosphatases. These cascades ultimately culminate in activation or deactivation of effector cells, resulting in initiation or down-modulation of cellular processes. Recent evidence points to a crucial in vivo role of Fc gamma R in both initiation and regulation of inflammatory and cytotoxic responses. These Fc gamma R-mediated immune responses can be exploited to develop novel immunotherapies.
Heijnen
I A
IA
Department of Immunology and Medarex Europe BV, G04.614, University Hospital Utrecht, The Netherlands.
van de Winkel
J G
JG
D006801:Humans; D017452:Receptors, IgG / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction
D017452:Receptors, IgG