title: The electroneutral cation-chloride cotransporters.
abstract: Electroneutral cation-chloride cotransporters are widely expressed and perform a variety of physiological roles. A novel gene family of five members, encompassing a Na+-Cl- transporter, two Na+-K+-2Cl- transporters and two K+-Cl- cotransporters, encodes these membrane proteins; homologous genes have also been identified in a prokaryote and a number of lower eukaryotes. The cotransporter proteins share a common predicted membrane topology, with twelve putative transmembrane segments flanked by long hydrophilic N- and C-terminal cytoplasmic domains. The molecular identification of these transporters has had a significant impact on the study of their function, regulation and pathophysiology.
authors.affiliation: Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA.
authors.forename: D B
authors.initials: DB
authors.lastname: Mount
authors.forename: E
authors.initials: E
authors.lastname: Delpire
authors.forename: G
authors.initials: G
authors.lastname: Gamba
authors.forename: A E
authors.initials: AE
authors.lastname: Hall
authors.forename: E
authors.initials: E
authors.lastname: Poch
authors.forename: R S
authors.initials: RS
authors.lastname: Hoover
authors.forename: S C
authors.initials: SC
authors.lastname: Hebert
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000502:physiology*; D002412:Cations / Q000378:metabolism*; D002712:Chlorides / Q000378:metabolism*; D006801:Humans; D017136:Ion Transport
chemical_list: D002352:Carrier Proteins; D002412:Cations; D002712:Chlorides