title: Short-term intermittent normobaric hypoxia--haematological, physiological and mental effects.
abstract: Effects on erythropoiesis and blood pressure as well as physical performance and mental effects were studied in 15 healthy subjects during intermittent exposure to normobaric hypoxia corresponding to either 2000 m (6 persons) or 2700 m (9 persons) above sea level; another group (5 persons) also served as controls at normoxia. The concept "live high-train low" was used for 10 d consecutively and the exposure to hypoxia was 12 h/d. Blood pO2 and oxygen saturation were significantly decreased during the 10 d at hypoxia. [Hb] and Hct decreased significantly after 2 d in hypoxia and then returned to pre-study levels. Erythropoietin was significantly elevated in both hypoxia groups during the initial 3-5 d. Reticulocytes were significantly increased during 7 d of hypoxia. Submaximal and maximal oxygen uptake, blood pressure at rest and during exercise and the profile of mood states (POMS test) did not change during the study. In conclusion, intermittent normobaric hypoxia for 10 d resulted in a significant stimulation of erythropoiesis. Staying at normobaric hypoxia may serve as a complement to an ordinary altitude level sojourn.
authors.affiliation: Department of Medicine, University of Uppsala, Falun, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Piehl Aulin
authors.forename: J
authors.initials: J
authors.lastname: Svedenhag
authors.forename: L
authors.initials: L
authors.lastname: Wide
authors.forename: B
authors.initials: B
authors.lastname: Berglund
authors.forename: B
authors.initials: B
authors.lastname: Saltin
mesh_terms: D000328:Adult; D001794:Blood Pressure; D004920:Erythropoiesis; D004921:Erythropoietin / Q000097:blood; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D008606:Mental Processes; D010101:Oxygen Consumption; D013997:Time Factors
chemical_list: D004921:Erythropoietin