title: [A case of secondary invasive pulmonary aspergillosis originating from an aspergilloma, successfully treated with itraconazole].
abstract: A 65-year-old man was admitted to our division with of productive cough and hemosputum. Chest radiographs and chest CT on admission showed old inflammatory shadows in both upper lung fields and a fungus ball in the left upper lung field. Despite antibiotic treatment, the patient's sputum volume increased and Aspergillus niger was repeatedly cultured from his sputum. Chest radiographs showed deterioration around the intracavitary fungus ball and a test for serum aspergillus antigen was positive. Secondary invasive pulmonary aspergillosis originating from aspergilloma was diagnosed based on his clinical symptoms, radiographic features and laboratory data. Administration of fluconazole failed to improve his clinical course and amphotericin B was discontinued because of hypokalemia. Oral administration of itraconazole was a successful treatment.
authors.affiliation: Department of Internal Medicine, National Kumamoto South Hospital, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nakagawa
authors.forename: K
authors.initials: K
authors.lastname: Shimazu
authors.forename: M
authors.initials: M
authors.lastname: Ebihara
authors.forename: K
authors.initials: K
authors.lastname: Amann
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy* / Q000382:microbiology; D001234:Aspergillus niger / Q000302:isolation & purification; D018450:Disease Progression; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use*; D008172:Lung Diseases, Fungal / Q000188:drug therapy* / Q000382:microbiology; D008297:Male
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole