Mortality in the first 2 years among infants born to human immunodeficiency virus-infected women in Harare, Zimbabwe.
Transmission of human immunodeficiency virus (HIV) and mortality was studied among infants of infected women in Zimbabwe. Of 367 infants born to HIV-infected women, 72 (19.6%) died compared with 20 (5.4%) of 372 infants of uninfected women (P < .01). Infection by HIV DNA polymerase chain reaction among infants who survived >7 days and died within 2 years could be assessed in 87% (58/67) of infants of infected women and 83% (5/6) of infants of uninfected women; transmission occurred in 40 of 58 infants. Among 27 infected infants tested at birth, 19 (70%), 5 (19%), and 3 (11%) were apparently infected via in utero, intrapartum or early postpartum, and late postpartum transmission, respectively. The majority of HIV-infected infants who died in the first 2 years of life were likely to have acquired in utero infection.
Zijenah
L
L
Department of Immunology, University of Zimbabwe, Harare.
Mbizvo
M T
MT
Kasule
J
J
Nathoo
K
K
Munjoma
M
M
Mahomed
K
K
Maldonado
Y
Y
Madzime
S
S
Katzenstein
D
D
D000328:Adult; D004279:DNA, Viral / Q000097:blood; D005260:Female; D015658:HIV Infections / Q000401:mortality* / Q000635:transmission*; D015497:HIV-1 / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D007226:Infant Mortality; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D015030:Zimbabwe / Q000453:epidemiology
D004279:DNA, Viral