title: Topical PUVA therapy for chronic hand eczema.
abstract: Seventeen patients with persistent chronic hand eczema were treated with topical 0.1% 8-methoxypsoralen and UVA (PUVA) for 8 weeks. Significant improvement was achieved in 5 cases (29%), moderate improvement in 9 (53%), and little improvement in 3 (18%). The mean number of PUVA treatments was 22.2, and the mean total UVA dose was 63.5 J/cm2. There was no association between clinical response and duration of hand eczema, positive patch test reaction, or atopic status. Since topical PUVA has no risk of systemic side effects, it should be considered as an alternative treatment for patients with chronic hand eczema who are resistant to other topical medications.
authors.affiliation: Institute of Dermatology, Bangkok, Thailand.
authors.forename: P
authors.initials: P
authors.lastname: Gritiyarangsan
authors.forename: A
authors.initials: A
authors.lastname: Sukhum
authors.forename: P
authors.initials: P
authors.lastname: Tresukosol
authors.forename: P
authors.initials: P
authors.lastname: Kullavanijaya
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D004485:Eczema / Q000188:drug therapy*; D005260:Female; D006229:Hand Dermatoses / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008730:Methoxsalen / Q000008:administration & dosage*; D008875:Middle Aged; D011701:PUVA Therapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage*
chemical_list: D017319:Photosensitizing Agents; D008730:Methoxsalen