[Usefulness of biochemical tumor markers (CEA, Ca 19-9, ferritin and sialic acid) in diagnosis and prognosis of colonic neoplasms].
The aim of the study was: to determine the value of CEA, Ca 19-9, ferritin and sialic acid in diagnostics, to assess the prognostic role of serum CEA and Ca 19-9 levels before surgery and to evaluate their usefulness in diagnostics of recurrences. The study included 352 patients with colorectal carcinoma (adenocarcinoma). The preoperative level of CEA was elevated in 286 patients, Ca 19-9 in 108, ferritin in 60 and sialic acid in 58 patients. All of them are poor markers in diagnostics because of the low sensitivity, respectively 47.6%, 37.0%, 16.7% and 55.2%. Preoperative high, CEA and Ca 19-9 values are associated with a significantly poorer prognosis and with frequency of recurrences.
Krasnodebski
I W
IW
Katedry i Kliniki Chirurgii Gastroenterologicznej Akademii Medycznej, Warszawie.
D000230:Adenocarcinoma / Q000175:diagnosis* / Q000601:surgery; D014408:Biomarkers, Tumor / Q000032:analysis*; D018395:CA-19-9 Antigen / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000097:blood; D003110:Colonic Neoplasms / Q000175:diagnosis* / Q000601:surgery; D005293:Ferritins / Q000032:analysis; D006801:Humans; D007813:Laparotomy; D019158:N-Acetylneuraminic Acid / Q000032:analysis; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis; D009367:Neoplasm Staging; D010166:Palliative Care; D011300:Preoperative Care; D011379:Prognosis; D012680:Sensitivity and Specificity
D014408:Biomarkers, Tumor; D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen; D005293:Ferritins; D019158:N-Acetylneuraminic Acid
Przydatność biochemicznych markerów nowotworowych (CEA, Ca 19-9, ferrytyna i kwas sialowy) w diagnostyce i rokowaniu raka jelita grubego.