[Human leucocyte antigen-DQA1, -DQB1 polymorphism distribution in Shanghai Chinese women with pregnancy induced hypertension].
OBJECTIVE
To explore the mechanism of correlation between human leucocyte antigen (HLA) and pregnancy induced hypertension (PIH).


METHODS
Oligotyped HLA-DQA1, -DQB1 locus in 30 Shanghai Chinese PIH families and 14 control families were analysed by polymerase chain reaction-sequence specific oligonucleotide (PCR-SSO) hybridization method (probes labelled by nonradioactive technique).


RESULTS
Compared with the control group, the allelic frequency of HLA-DQB1 * 0502 was significantly higher in PIH couples, and their sharing of HLA-DQA1 increased. No difference was found in HLA-DQA1 allelic frequency or HLA-DQB1 sharing in couples of the two groups. Analysis of HLA-DQA1 and DQB1 allelic frequency in PIH patients and their neonates showed no positive results.


CONCLUSIONS
HLA-DQB1 * 0502 may be the marker of susceptibility to PIH. The increase of compatibility in HLA-D region resulted in decrease of producting blocking antibody. The unbalance of maternal-fetal immunity will induce PIH.
Mao
Y
Y
Obstetrics and Gynecology Hospital, Shanghai Medical University.
Zhang
Z
Z
Wu
Q
Q
D000328:Adult; D000483:Alleles; D005260:Female; D006683:HLA-DQ Antigens / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000209:etiology / Q000235:genetics*; D011247:Pregnancy
D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; C069050:HLA-DQA1 antigen; C069051:HLA-DQB1 antigen