Coexistence of chronic myelogenous leukemia and multiple myeloma. Case report and review of the literature.
A case report of simultaneous presentation of chronic myelogenous leukemia (CML) and multiple myeloma (MM) in a 72-year-old female is described. Our case was typical of Ph1-positive and chimeric bcr-abl messenger RNA-positive CML. Furthermore, a marked IgG (kappa-type) paraproteinemia was present. Fluorescence in situ hybridization showed that 97% of marrow nucleated cells were positive for bcr-abl fusion signal, when myeloma cells in the bone marrow amounted to 19.0%. In the literature survey, 4 similar cases with coexistence of CML and MM have been identified.
Tanaka
M
M
First Department of Internal Medicine, Kurume University School of Medicine, Fukuoka, Japan. m-tanaka@kurume.ktarn.or.jp
Kimura
R
R
Matsutani
A
A
Zaitsu
K
K
Oka
Y
Y
Oizumi
K
K
D000368:Aged; D001854:Bone Marrow Cells / Q000737:chemistry / Q000473:pathology; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000032:analysis; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007145:Immunoglobulin kappa-Chains / Q000097:blood; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000473:pathology; D009101:Multiple Myeloma / Q000150:complications* / Q000473:pathology; D010265:Paraproteinemias / Q000150:complications
D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains; D016044:Fusion Proteins, bcr-abl