In vitro evaluation of the cytotoxic, hemolytic and clastogenic activities of Rhizostoma pulmo toxin(s).
Cytotoxic, hemolytic and clastogenic activities of Rhizostoma pulmo toxin(s) contained in the jelly tissue free of nematocysts were investigated in mammalian cells with in vitro procedures. At the concentration of 37.6 microg/ml the tissue protein produced the death of 50% V79 cells; a similar potency was observed in terms of hemolytic activity. The toxin(s) was not clastogenic for human lymphocytes in culture at the concentration of 5 microg/ml.
Allavena
A
A
Department of Internal Medicine, Pharmacology and Toxicology Unit, University of Genoa, Italy.
Mariottini
G L
GL
Carli
A M
AM
Contini
S
S
Martelli
A
A
D000818:Animals; D002460:Cell Line; D004912:Erythrocytes / Q000187:drug effects*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008387:Marine Toxins / Q000633:toxicity*; D015162:Micronucleus Tests; D037401:Scyphozoa
D008387:Marine Toxins