title: Tissue response and the cytoconduction ability to collagen/hydroxyapatite heterotopic implantation.
abstract: A histological and ultrastructural observation of CHA implanted intramuscularly and subcutaneously had been reported. Our results showed that a mild inflammation developed at the early stage and disappeared 2 weeks after implantation. The infiltrating cells were mainly monocyte-macrophages, a number of fibroblasts followed macrophages closely. It was possible that as CHA degrades, monocyte-macrophages continuously released inflammatory factors, thus enhancing fibroblast proliferation activity and tissue regeneration. In addition, the heterotopic calcification of collagen matrix was observed, suggesting that CHA promoted calcification deposition.
authors.affiliation: Department of Orthopedics, Xiehe Hospital, Tongji Medical University, Wuhan.
authors.forename: Z
authors.initials: Z
authors.lastname: Xia
authors.forename: T
authors.initials: T
authors.lastname: Zhu
authors.forename: J
authors.initials: J
authors.lastname: Du
authors.forename: L
authors.initials: L
authors.lastname: Wang
mesh_terms: D000818:Animals; D002113:Calcification, Physiologic; D003094:Collagen; D017886:Durapatite; D020007:Implants, Experimental; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010012:Osteogenesis
chemical_list: D003094:Collagen; D017886:Durapatite