Preparation of a novel functional hydrogel consisting of sulfated glucoside-bearing polymer: activation of basic fibroblast growth factor.
Sulfated poly(glucosyloxyethyl methacrylate) [poly(GEMA)-sulfate] and its hydrogel were synthesized and evaluated to develop novel tissue regeneration assist devices. The poly(GEMA)-sulfate hydrogel was obtained by gamma-ray irradiation. Basic fibroblast growth factor (bFGF) was expected to be subsequently incorporated with hydrogel matrices and activated or released from the matrices. A sustained release of bFGF from the poly(GEMA)-sulfate hydrogel was not realized; however, bFGF from poly(GEMA)-sulfate hydrogel was effectively activated. Poly(GEMA)-sulfate hydrogels are thought to be potential component materials for a tissue engineering matrix.
Taguchi
T
T
Department of Applied Chemistry and Chemical Engineering, Faculty of Engineering, Kagoshima University, Japan.
Kishida
A
A
Sakamoto
N
N
Akashi
M
M
D002448:Cell Adhesion; D002460:Cell Line; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism*; D005960:Glucosides / Q000138:chemical synthesis* / Q000494:pharmacology; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols; D011108:Polymers / Q000138:chemical synthesis* / Q000494:pharmacology; D013431:Sulfates / Q000737:chemistry
D005960:Glucosides; D011108:Polymers; D013431:Sulfates; D016222:Fibroblast Growth Factor 2; C090633:poly(glucosylethyl methacrylate); D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols