title: Myoglobin clearance during continuous veno-venous hemofiltration with or without dialysis.
abstract: The management of acute myoglobinuric renal failure, the major complication of rhabdomyolysis, continues to be a treatment dilemma for the clinician as limited therapeutic options are available. Previously, we have demonstrated that continuous arteriovenous hemofiltration (CAVH) is an effective technique for removing myoglobin in an animal model. In the present study, swine were administered four grams of equine myoglobin intravenously and underwent the continuous veno-venous hemofiltration (CVVH) procedure for six hours each. Animals were studied in each of the following groups: CVVH at a pump rate 100 ml/minute, CVVH at a pump rate 200 ml/minute and CVVH at a pump rate 100 ml/minute plus dialysis at a dialysate flow rate of one Liter/h. Once the filtering process was initiated there was a rapid and sustained production of ultrafiltrate in all groups. The amount of myoglobin excreted in the ultrafiltrate over the six-hour filtering period was 688, 948 and 570 mg which corresponded to 17, 24 and 14 percent of the administered dose, respectively, for the three treatments. In comparison to previous CAVH experiments, CVVH removed more circulating myoglobin and the addition of the dialysis component did not appear to improve removal. Based on these findings, it appears that the CVVH hemofiltration system is a viable option for the removal of systemic myoglobin.
authors.affiliation: Department of Pharmacy, Hartford Hospital, Connecticut 06102, USA.
authors.forename: D
authors.initials: D
authors.lastname: Nicolau
authors.forename: Y S
authors.initials: YS
authors.lastname: Feng
authors.forename: A H
authors.initials: AH
authors.lastname: Wu
authors.forename: S P
authors.initials: SP
authors.lastname: Bernstein
authors.forename: C H
authors.initials: CH
authors.lastname: Nightingale
mesh_terms: D000818:Animals; D005260:Female; D006440:Hemofiltration; D006736:Horses; D007275:Injections, Intravenous; D009211:Myoglobin / Q000008:administration & dosage / Q000097:blood*; D006435:Renal Dialysis; D013552:Swine
chemical_list: D009211:Myoglobin