[Genetic aspects of silicosis: polymorphic gene distribution frequency].
Electrophoresis and isoelectrofocusing were used to study polymorphism by 7 genetic loci: haptoglobin (Hp), proteinase inhibitor (PI), transferrin (TF), Vitamin D-transporting protein (GC), complement 3 (C3), phosphoglucomutase 1 (PGM1) and glyoxalase (GLO1) in 60 patients with silicosis and in 70 apparently healthy workers of the Dynamo plant. Comparison of the study groups by significant differences in the summary of the genetic information obtained suggests that 5 (Hp, C3, TF, PI, PGM1) of the 7 studied systems showed the hereditary features of silicosis. The gene carriers Hp*2, C3*F, PGM1*2-, PI*M1, TF*C1, TF*C16 TF*D, GC*R due to peculiar biochemical processes appear to have less adaptive potentialities and a greater likelihood of the disease on exposure to industrial factors.
Kuz'mina
L P
LP
Spitsyn
V A
VA
Tarasova
L A
LA
Milishnikova
V V
VV
D000328:Adult; D000368:Aged; D000483:Alleles; D003176:Complement C3 / Q000235:genetics; D005787:Gene Frequency; D006242:Haptoglobins / Q000235:genetics; D006801:Humans; D007791:Lactoylglutathione Lyase / Q000235:genetics; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects; D010733:Phosphoglucomutase / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D011480:Protease Inhibitors / Q000378:metabolism; D012426:Russia; D012829:Silicosis / Q000209:etiology / Q000235:genetics* / Q000378:metabolism; D014168:Transferrin / Q000235:genetics; D014809:Vitamin D-Binding Protein / Q000235:genetics
D003176:Complement C3; D006242:Haptoglobins; D011480:Protease Inhibitors; D014168:Transferrin; D014809:Vitamin D-Binding Protein; D007791:Lactoylglutathione Lyase; D010733:Phosphoglucomutase
Geneticheskie aspekty silikoza: osobennosti raspredeleniia chastot polimorfnykh genov.