[The influence of salmon calcitonin on the soluble form of VCAM-1 (CD 106) and E-selectin (CD 62E) in serum of patients with atopic bronchial asthma].
The aim of the study was to evaluate the effect of salmon calcitonin (CT) on serum level of soluble form of VCAM-1 (sVCAM-1 = soluble vascular cell adhesion molecule-1) and E-selectin (sE-selectin = soluble E-selectin) in patients with atopic bronchial asthma. Twenty-four individuals divided into 4 groups (6 persons each) were investigated. The first group consisted of patients with chronic moderate bronchial asthma, the second and third groups consisted of patients with mild bronchial asthma and the fourth group K consisted of healthy individuals. The patients of the first and second group were treated with CT at a dose of 100 i.v./days s.c. for three days. The patients of the third group were given placebo (phychological saline) in similar way as CT. The indices were measured before the treatment with CT or placebo and on the 4th day of the treatment. It was found that CT treatment decreased sVCAM-1 in serum only in the patients of the first group (p < 0.05) but had no effect upon sE-selectin level. The obtained results suggest that CT interfered into mechanisms of inflammation involving adhesion molecules in patients with bronchial asthma.
Polanowicz
U
U
IV Katedry i Kliniki Chorób Wewnetrznych, Slaskiej Akademii Medycznej, Tychach.
Gina
A R
AR
Pieczyrak
R
R
Jonderko
G
G
Kucharz
E J
EJ
Kondera-Anasz
Z
Z
Krupnik
B
B
D000328:Adult; D000818:Animals; D001249:Asthma / Q000097:blood / Q000188:drug therapy*; D002116:Calcitonin / Q000494:pharmacology* / Q000627:therapeutic use; D019040:E-Selectin / Q000097:blood / Q000187:drug effects*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D012474:Salmon; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood / Q000187:drug effects*
D019040:E-Selectin; D019010:Vascular Cell Adhesion Molecule-1; D002116:Calcitonin
Wpływ kalcytoniny łososiowej na stezenie rozpuszczalnych form VCAM-1 (CD 106) i e-selektyny (CD 62E) w surowicy u chorych na astme oskrzelowa atopowa.