[Response of the isolated muscle tissue of frog species to the successive effects of subtoxic and toxic chloral hydrate solutions].
Time-related changes in the mean resistance of sartorius muscle from individual common frogs to the toxic effect of chloral hydrate (0.05 and 0.08 M) were observed. The correlation coefficient between the initial muscle resistance and the value and direction of its changes as well as between the resistance of the paired muscle under the influence of subtoxic chloral hydrate solution (0.005 M) was calculated. A biphase pattern of change of almost all the above indices depending on the dose of pretreatment was observed. Time-related changes in the correlation coefficient between muscle resistance and its changes and between the resistance of the paired muscle and variability of the resistance proved to be much more informative than the mean resistance concerning both the muscle response to the stimulus and functional state of the muscle cells.
Mironova
A P
AP
Institute of Cytology, Russian Academy of Sciences, St.-Petersburg, Russia.
D000222:Adaptation, Physiological; D000818:Animals; D002697:Chloral Hydrate / Q000008:administration & dosage / Q000633:toxicity*; D003627:Data Interpretation, Statistical; D004305:Dose-Response Relationship, Drug; D018482:Muscle, Skeletal / Q000187:drug effects*; D011898:Ranidae; D013045:Species Specificity; D013997:Time Factors
D002697:Chloral Hydrate
Reaktsiia izolirovannoĭ myshechnoĭ tkani raznykh osobeĭ liagushek na posledovatel'noe vozdeĭstvie subtoksicheskogo i toksicheskogo rastvorov khloralgidrata.