Effect of running training on brown adipose tissue activity in rats: a reevaluation.
The effect was investigated of running training on the thermogenic activity of brown adipose tissue (BAT) in rats. The exercised rats were trained on a rodent treadmill for 5 days per week and a total of 9 weeks. After the training, a significantly lower rate of increase in body weight was found, suggesting some training effect, whereas the training failed to induce a decrease in BAT mass. As previously reported (Yamashita, Yamamoto et al., 1993), there was also a markedly lower expression of uncoupling protein (UCP) mRNA in BAT from trained rats; nevertheless, no definite effect of the running training was noted on either UCP content or guanosine 5'-diphosphate binding in the mitochondria recovered from BAT. The results obtained suggest that running training has no overt effect on the thermogenic activity of BAT in rats.
Segawa
M
M
Department of Hygiene, National Defense Medical College, Tokorozawa, Japan.
Oh-Ishi
S
S
Kizaki
T
T
Ookawara
T
T
Sakurai
T
T
Izawa
T
T
Nagasawa
J
J
Kawada
T
T
Fushiki
T
T
Ohno
H
H
D002001:Adipose Tissue, Brown / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D002352:Carrier Proteins / Q000096:biosynthesis; D006153:Guanosine Diphosphate / Q000096:biosynthesis; D007473:Ion Channels; D008297:Male; D008565:Membrane Proteins / Q000096:biosynthesis; D008928:Mitochondria / Q000378:metabolism; D024101:Mitochondrial Proteins; D010805:Physical Conditioning, Animal / Q000502:physiology*; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar; D012420:Running / Q000502:physiology; D000071256:Uncoupling Protein 1
D002352:Carrier Proteins; D007473:Ion Channels; D008565:Membrane Proteins; D024101:Mitochondrial Proteins; D012333:RNA, Messenger; D000071256:Uncoupling Protein 1; D006153:Guanosine Diphosphate