title: [loop electrosurgical excision procedure: a review of our recent experience].
abstract: OBJECTIVE
  To investigated whether persistence or recurrence of cervical intraepithelial neoplasis (CIN) is associated with an involved excisional margin during loop electrosurgical excision procedure (LEEP).
  
  
  METHODS
  The records of 256 consecutive LEEP were studied. After LEEP, all patients were followed up by colposcopy and cytology at 4 to 6 month intervals for at least two years. A patient was classified as having persistent disease if SIL was seen within one year of treatment or recurrent disease if SIL was detected after one year of treatment. All relevant patient details including cytology, colposcopy findings, treatment histology, complications, recurrence or persistence of disease entered into a computer database.
  
  
  RESULTS
  Complications occurred in 8 patients (3.1%). LEEP was successful in treating 226 patients (95.4)%. Eleven patients (4.6%) had persistent SIL. Involvement of the resection margin was a significant risk factor for persistent disease (3.1% for uninvolved margins vs 11.4% for involved margins, P < 0.05). Similarly, recurrent disease occurred in 9.1% of patients with involved resection margins vs 2.1% with uninvolved margins (P < 0.05). Eleven patients (4.3%) had microinvasive carcinoma. Only 3 were identified by colposcopy and directed biopsy.
  
  
  CONCLUSIONS
  LEEP is established as a safe and efficacious method for the treatment of CIN, long term morbidity including the effect on subsequent fertility must be observed.
authors.affiliation: Department of Obstetrics and Gynecology, Queen Mary Hospital, Hong Kong.
authors.forename: T Y
authors.initials: TY
authors.lastname: Ng
authors.forename: K L
authors.initials: KL
authors.lastname: Liu
authors.forename: D K
authors.initials: DK
authors.lastname: Cheng
mesh_terms: D004598:Electrosurgery / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D009364:Neoplasm Recurrence, Local; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000601:surgery*; D002578:Uterine Cervical Dysplasia / Q000473:pathology / Q000601:surgery*