Hemorrhagic and thrombotic complications in patients with myeloproliferative diseases.
OBJECTIVE
To correlate the incidence of hemorrhage and thrombosis to bleeding time (BT) and platelet aggregation in 27 consecutive patients with myeloproliferative diseases (MPD).


METHODS
Retrospective study.


METHODS
Public tertiary referral center.


METHODS
Eighteen patients with chronic myelogenous leukemia (CML), 5 with polycytemia vera (PV), 2 with essential thrombocytemia (ET) and 2 with idiopathic myelofibrosis (MF). Duke's BT and epinephrine-induced platelet aggregation were performed on the patients and on 10 healthy individuals.


RESULTS
Eleven patients presented symptoms (41%):9 with hemorrhage (33%) and 5 with thrombosis (19%). There were less symptomatic patients in the CML group (28%) than in the other MPD (67%), without statistical significance (Fisher, p = 0.06). Duke's BT was longer in symptomatic patients (Mann-Whitney, p < 0.05). Platelet aggregation was abnormal in 7 patients (26%) and 71% of them were symptomatic (Fisher, p = 0.07).


CONCLUSIONS
The high incidence of bleeding and thrombosis in patients with MPD was related to prolonged BT, but not to platelet aggregation abnormalities.
Vignal
C V
CV
Department of Hematology, Universidade Federal de São Paulo, Brazil.
Lourenço
D M
DM
Noguti
M A
MA
Chauffaille
M de L
Mde L
Kerbauy
J
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D001760:Bleeding Time; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D005500:Follow-Up Studies; D006470:Hemorrhage / Q000209:etiology*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000150:complications*; D010974:Platelet Aggregation / Q000187:drug effects; D010976:Platelet Count; D012189:Retrospective Studies; D013927:Thrombosis / Q000209:etiology*
D004837:Epinephrine