title: Physiological and performance responses to supplementation with thiamin and pantothenic acid derivatives.
abstract: The purpose of this study was to investigate the physiological and performance responses to supplementation with allithiamin and pantethine. On two separate occasions, six highly trained cyclists [maximum O2 consumption or VO2max 61.8 (2.1) ml x kg(-1) x min(-1)] performed a 50-km steady-state ride on a cycle ergometer at a workload corresponding to approximately 60% of VO2max followed by a 2000-m time trial. For 7 days prior to each ride, subjects daily ingested either a placebo (PL) or a combination of 1 g of allithiamin and 1.8 g of a 55%/45% pantethine/pantothenic acid compound (AP). Treatments were administered using a randomized, double-blind, counter-balanced design. During the 50km ride, measures of heart rate, respiratory gas exchange and ratings of perceived exertion were recorded at 5, 15, 25, 35 and 45 km. Blood samples were collected at 10, 20, 30, 40 and 50 km and analyzed for lactate, glucose and free fatty acids. Blood samples for the analysis of lactate were also collected 3 and 5 min after the completion of the 2000-m time trial. There were no significant differences in any of the measured parameters between experimental conditions. Time to complete the 2000-m time trial was also not significantly different between experimental conditions [PL 178.2 (8.4), AP 170.7 (10.2) s; P=0.58]. These results suggest that, despite the reported enhanced absorption properties, supplementation with allithiamin and pantethine does not alter exercise metabolism or exercise performance.
authors.affiliation: Laboratory of Applied Physiology, School of Human Performance and Recreation, University of Southern Mississippi, Hattiesburg 39406, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Webster
mesh_terms: D000328:Adult; D001642:Bicycling / Q000502:physiology; D001786:Blood Glucose / Q000378:metabolism; D004311:Double-Blind Method; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D019344:Lactic Acid / Q000097:blood; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D010204:Pantetheine / Q000008:administration & dosage / Q000031:analogs & derivatives; D010205:Pantothenic Acid / Q000008:administration & dosage*; D011659:Pulmonary Gas Exchange / Q000187:drug effects; D013831:Thiamine / Q000008:administration & dosage* / Q000031:analogs & derivatives
chemical_list: D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D010205:Pantothenic Acid; D019344:Lactic Acid; D010204:Pantetheine; C005425:pantethine; C012710:allithiamine; D013831:Thiamine