title: Glycogen-forming function of hepatocytes in the rat regenerating cirrhotic liver after a partial hepatectomy.
abstract: Rat liver punctate biopsies were used for cytofluorimetric determinations of the content of glycogen and its fractions in hepatocytes, and also for microchemical measurements of the activity of glucose-6-phosphatase, glycogen phosphorylase, and glycogen synthase, in liver tissue with cirrhosis produced by carbon tetrachloride (CCl4) poisoning, during regeneration of the liver after the cessation of poisoning and after a partial resection of the cirrhosed liver. The liver cirrhosis was shown to be characterized by an accumulation of glycogen (predominantly of its metabolically less active fraction) in hepatocytes and by a decrease in the activities of the glycogenolytic enzymes in the liver parenchyma. On the cessation of poisoning, there was a partial or complete return to normal levels of the glycogen metabolism parameters. Some of them returned to normal more quickly if a partial hepatectomy was performed after the cessation of poisoning.
authors.affiliation: Institute of Cytology, Russian Academy of Sciences, St Petersburg, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Kudryavtseva
authors.forename: A V
authors.initials: AV
authors.lastname: Emelyanov
authors.forename: G A
authors.initials: GA
authors.lastname: Sakuta
authors.forename: N N
authors.initials: NN
authors.lastname: Bezborodkina
authors.forename: B N
authors.initials: BN
authors.lastname: Kudryavtsev
mesh_terms: D000818:Animals; D001706:Biopsy; D002251:Carbon Tetrachloride; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D006003:Glycogen / Q000032:analysis / Q000096:biosynthesis*; D006006:Glycogen Synthase / Q000378:metabolism; D006498:Hepatectomy; D008099:Liver / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000378:metabolism* / Q000601:surgery; D008115:Liver Regeneration / Q000502:physiology*; D008297:Male; D008861:Microsomes / Q000201:enzymology; D006005:Phosphorylases / Q000378:metabolism; D051381:Rats
chemical_list: D006003:Glycogen; D002251:Carbon Tetrachloride; D006005:Phosphorylases; D006006:Glycogen Synthase; D005952:Glucose-6-Phosphatase