[The immunomodulating activity of a transfer-factor preparation transflavin, specific to tick-borne encephalitis virus].
Transflavin, a transfer-factor preparation specific to tick-borne encephalitis virus, was experimentally shown to possess immunomodulating action. The immunomodulating action of this preparation could be observed in a dose of 1 D (1 D being equivalent to 5 x 10(8) lymphocytes), which was manifested by an increase in the phagocytic activity of neutrophils and macrophages, a rise in the amount of T-lymphocytes, an increase in rosette formation, the number of antibody-forming cells, increased proliferation on T- and, to a lesser extent, B-cell mitogens, the restoration of the T-dependent expression of lymphocyte receptors, inhibited by trypsin. Transflavin in doses of 0, 1 and 10 D suppressed primary immune response. The probable mechanisms of the immunomodulating action of the Transflavin under study is discussed.
Iushkova
T A
TA
Iushkov
V V
VV
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects; D004669:Encephalitis Viruses, Tick-Borne / Q000187:drug effects*; D051379:Mice; D008808:Mice, Inbred CBA; D013601:T-Lymphocytes / Q000187:drug effects; D014165:Transfer Factor / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D014165:Transfer Factor
Immunomoduliruiushchaia aktivnost' transferfaktornogo preparata transflavina, spetsifichnogo virusu kleshchevogo entsefalita.