title: Malononitrilamides reduce IgM and IgG xenoantibodies and prolong skin xenograft survival in a mouse-to rat model.
authors.affiliation: Research Laboratories Hoechst Marion Roussel, Pharma Research Werk Kalle-Albert, Wiesbaden, Germany.
authors.forename: H U
authors.initials: HU
authors.lastname: Schorlemmer
authors.forename: R
authors.initials: R
authors.lastname: Kurrle
mesh_terms: D000208:Acute Disease; D000480:Alkynes; D000818:Animals; D000910:Antibodies, Heterophile / Q000096:biosynthesis*; D000917:Antibody Formation / Q000187:drug effects; D016572:Cyclosporine / Q000627:therapeutic use; D006084:Graft Rejection / Q000276:immunology / Q000517:prevention & control*; D006085:Graft Survival / Q000187:drug effects / Q000276:immunology*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007555:Isoxazoles; D051379:Mice; D008807:Mice, Inbred BALB C; D009570:Nitriles / Q000627:therapeutic use*; D051381:Rats; D011917:Rats, Inbred Lew; D016038:Skin Transplantation / Q000276:immunology* / Q000473:pathology; D013997:Time Factors; D014183:Transplantation, Heterologous / Q000276:immunology* / Q000473:pathology
chemical_list: D000480:Alkynes; D000910:Antibodies, Heterophile; D007166:Immunosuppressive Agents; D007555:Isoxazoles; D009570:Nitriles; C102911:X 910279; C115284:2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide; D016572:Cyclosporine