Review of ionic models of vagal-cardiac pacemaker control.
Mathematical models of ion currents in pacemaker cells of the heart and their associated modulation by vagal stimulation have provided numerous insights into the ionic mechanisms underlying parasympathetic control of heart rate. In this article, ionic models described in the literature are reviewed and compared, with a view to examining their effectiveness in reproducing known chronotropic responses to vagal stimulation.
Dokos
S
S
Department of Physiology, School of Medicine, University of Auckland, New Zealand.
Lovell
N H
NH
Celler
B G
BG
D003198:Computer Simulation; D006329:Heart Conduction System / Q000502:physiology*; D006801:Humans; D017136:Ion Transport; D008955:Models, Cardiovascular; D014630:Vagus Nerve / Q000502:physiology*