title: Apolipoprotein E polymorphism in Alzheimer's disease: a comparative study of two research populations from Spain and the United States.
abstract: We examined the distribution of the apolipoprotein E (APOE) polymorphism in two Caucasian populations of Alzheimer's disease (AD) patients referred to dementia clinics; one in Gerona, Spain (66 AD patients, 49 controls), and the other in Pittsburgh, Pa., USA (209 AD patients, 58 controls). The presence of the APOE*4 allele was a significant risk for developing AD in both cohorts: Gerona (odds ratio = 2.34, CI: 1.03-5.55) and Pittsburgh (odds ratio = 3.64, CI: 1.78-7.69). The proportion of AD with the APOE*4 allele was greater in the Pittsburgh cohort than in the Gerona cohort (p = 0.02). However, no statistical difference was noted between the two populations in nondemented controls (p = 0.41). These data emphasize the importance of geographical and ethnic variations in the study of APOE genotypes.
authors.affiliation: Alzheimer's Disease Research Center, Department of Neurology, University of Pittsburgh School of Medicine, PA, USA.
authors.forename: O L
authors.initials: OL
authors.lastname: Lopez
authors.forename: S
authors.initials: S
authors.lastname: Lopez-Pousa
authors.forename: M I
authors.initials: MI
authors.lastname: Kamboh
authors.forename: R
authors.initials: R
authors.lastname: Adroer
authors.forename: R
authors.initials: R
authors.lastname: Oliva
authors.forename: M
authors.initials: M
authors.lastname: Lozano-Gallego
authors.forename: J T
authors.initials: JT
authors.lastname: Becker
authors.forename: S T
authors.initials: ST
authors.lastname: DeKosky
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D016022:Case-Control Studies; D003710:Demography; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011110:Polymorphism, Genetic; D012107:Research Design; D012307:Risk Factors; D013030:Spain; D014481:United States; D044465:White People / Q000235:genetics*
chemical_list: D001057:Apolipoproteins E