Pancreatic leiomyosarcoma. Case report with immunohistochemical and flow cytometric studies.
A leiomyosarcoma originating from the pancreas of a 57-year-old man is presented. A 6x5x4 cm tumour was located in the head region, and the patient underwent surgical palliation. Immunohistochemical studies excluded an epithelial origin; a myogenic origin was suggested by strong vimentin and smooth muscle actin positivity. Flow cytometric analysis revealed an aneuploid pattern (DNA index: 1,561). The patient died with widespread metastases 7 month after the operation.
Zalatnai
A
A
1st Institute of Pathology and Experimental Cancer Research, Semmelweis University of Medicine, Budapest, Hungary. zalatnai@korb1.sote.hu
Kovács
M
M
Flautner
L
L
Sipos
B
B
Sarkady
E
E
Bocsi
J
J
D000199:Actins / Q000378:metabolism; D000782:Aneuploidy; D004273:DNA, Neoplasm / Q000378:metabolism; D017809:Fatal Outcome; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D007890:Leiomyosarcoma / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D014746:Vimentin / Q000378:metabolism
D000199:Actins; D004273:DNA, Neoplasm; D014746:Vimentin