Onset age-dependent variations of three islet specific autoantibodies in Japanese IDDM patients.
The age related incidence rate of insulin-dependent diabetes mellitus shows a bimodal distribution, not only in Caucasians but also in Japanese. To evaluate the onset age-related autoimmune profile at presentation in insulin-dependent diabetes mellitus (IDDM), glutamic acid decarboxylase (GAD) autoantibody, islet cell antibody (ICA), and insulin autoantibody (IAA) were measured in 137 newly diagnosed Japanese IDDM patients with onset ages between 0-29 years. The prevalence of GAD autoantibody was significantly increased from the lowest (32%) in the 0-5 years onset age group to 75% in the 13-19 years onset age group (P < 0.05), whereas the IAA prevalence significantly decreased from the peak (48%) in the 6-12 years onset age group to 10% in the 20-29 years onset age group (P < 0.05). The ICA prevalence was increased from the lowest (32%) in the 0-5 years onset age group to the highest (53%) in the 20-29 years onset age group similar to that for the GAD autoantibody. Such results demonstrate that there was age-related autoimmune characteristics at presentation of IDDM in Japanese as well as in Caucasians.
Yamada
H
H
Diabetes Centre, Tokyo Women's Medical College, Japan.
Uchigata
Y
Y
Kawasaki
E
E
Matsuura
N
N
Otani
T
T
Sato
A
A
Mutoh
K
K
Kasahara
T
T
Fukushima
N
N
Koike
A
A
Mizota
M
M
Miura
J
J
Kubo
H
H
Yamaguchi
A
A
Nagataki
S
S
Omori
Y
Y
Iwamoto
Y
Y
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D044466:Asian People; D001323:Autoantibodies / Q000032:analysis*; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D005260:Female; D005968:Glutamate Decarboxylase / Q000276:immunology*; D006801:Humans; D007330:Insulin Antibodies / Q000032:analysis*; D007515:Islets of Langerhans / Q000276:immunology*; D007564:Japan; D008297:Male; D015995:Prevalence; D013954:Thyroglobulin / Q000276:immunology
D001323:Autoantibodies; D007330:Insulin Antibodies; D013954:Thyroglobulin; D005968:Glutamate Decarboxylase