Effect of oral supplementation of vitamin E on the hemolysis and erythrocyte phospholipid-splitting action of cobra and viper venoms.
In the present investigation, it was found that oral supplementation of graded amounts of vitamin E to volunteers increased the alpha-tocopherol content of the erythrocytes and decreased the susceptibility of the latter to the hemolytic action of cobra and viper venoms. Further, exogenous addition of graded amounts of alpha-tocopherol to the red cells, prior to the addition of either venoms, minimizes the venom-induced lysis and erythrocyte phospholipid splitting. It may thus be inferred that vitamin E, a fat-soluble antioxidant, plays an important role in reducing the hemolytic action of cobra and viper venoms.
Mukherjee
A K
AK
Department of Biochemistry, Burdwan Medical College, India.
Ghosal
S K
SK
Maity
C
C
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004546:Elapid Venoms / Q000633:toxicity*; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D006461:Hemolysis; D006801:Humans; D010743:Phospholipids / Q000378:metabolism*; D014757:Viper Venoms / Q000633:toxicity*; D017819:Viperidae; D014810:Vitamin E / Q000494:pharmacology*
D000975:Antioxidants; D004546:Elapid Venoms; D010743:Phospholipids; D014757:Viper Venoms; D014810:Vitamin E