Development of a macromolecular prodrug of FK 506: III: In vivo disposition of FK 506-dextran conjugate.
Yoshimura
N
N
Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan.
Yura
H
H
Hamashima
T
T
Oka
T
T
Takakura
Y
Y
Hadhida
M
M
D000818:Animals; D003911:Dextrans / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D007275:Injections, Intravenous; D008297:Male; D008657:Metabolic Clearance Rate; D011355:Prodrugs / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats; D011917:Rats, Inbred Lew; D016559:Tacrolimus / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D003911:Dextrans; C112843:FK 506-dextran conjugate; D007166:Immunosuppressive Agents; D011355:Prodrugs; D016559:Tacrolimus