Implications of hormesis for biomedical aging research.
Rather than being an exception, non-linearity between dose and response are the rule in biological systems. It might even be anticipated that at some doses a response opposite to that seen at high doses could be elicited (hormesis). Such non-linearity with dose has multiple implications for numerous aspects of biomedical research on aging and for experimental design. Moreover, the implications of such non-linearity are such that governmental regulatory activities and other areas of public health administration will be affected to a large extent once hormesis is widely recognized. The implications with regard to environmental intervention and subsequent regulatory decisions will certainly profoundly affect the political process, as well.
Johnson
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Institute for Behavioral Genetics, University of Colorado, Boulder 80309, USA.
Bruunsgaard
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D000368:Aged; D000375:Aging / Q000502:physiology*; D006801:Humans; D008136:Longevity; D011158:Population Growth; D012107:Research Design; D013315:Stress, Psychological / Q000503:physiopathology