Recombinant Sindbis viruses expressing a cytotoxic T-lymphocyte epitope of a malaria parasite or of influenza virus elicit protection against the corresponding pathogen in mice.
Subcutaneous administration in mice of recombinant Sindbis viruses expressing a class I major histocompatibility complex-restricted 9-mer epitope of the Plasmodium yoelii circumsporozoite protein or the nucleoprotein of influenza virus induces a large epitope-specific CD8(+) T-cell response. This immunization also elicits a high degree of protection against infection with malaria or influenza A virus.
Tsuji
M
M
Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, New York 10010, USA.
Bergmann
C C
CC
Takita-Sonoda
Y
Y
Murata
K
K
Rodrigues
E G
EG
Nussenzweig
R S
RS
Zavala
F
F
D000818:Animals; D004333:Drug Administration Routes; D018984:Epitopes, T-Lymphocyte / Q000276:immunology*; D005822:Genetic Vectors / Q000235:genetics; D006801:Humans; D009980:Influenza A virus / Q000254:growth & development / Q000276:immunology*; D007252:Influenza Vaccines / Q000276:immunology; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control*; D008288:Malaria / Q000517:prevention & control*; D051379:Mice; D008807:Mice, Inbred BALB C; D019590:Nucleocapsid Proteins; D009698:Nucleoproteins / Q000235:genetics / Q000276:immunology; D010967:Plasmodium yoelii / Q000235:genetics / Q000254:growth & development / Q000276:immunology*; D015800:Protozoan Proteins / Q000235:genetics / Q000276:immunology; D016052:Protozoan Vaccines / Q000276:immunology; D016053:RNA, Protozoan; D016601:RNA-Binding Proteins; D012845:Sindbis Virus / Q000235:genetics; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000276:immunology; D014758:Viral Core Proteins / Q000235:genetics / Q000276:immunology
D018984:Epitopes, T-Lymphocyte; D007252:Influenza Vaccines; C048842:NP protein, Influenza A virus; D019590:Nucleocapsid Proteins; D009698:Nucleoproteins; D015800:Protozoan Proteins; D016052:Protozoan Vaccines; D016053:RNA, Protozoan; D016601:RNA-Binding Proteins; D014614:Vaccines, Synthetic; D014758:Viral Core Proteins; C041595:circumsporozoite protein, Protozoan