Catecholamines: the cardiovascular and neuroendocrine system.
The development of profound autonomic dysfunction and of neuroendocrine activation characterizes and possibly contributes to the progression of heart disease to congestive heart failure. Sympathetic activation is a generalized process and the proposed mechanisms for neurohumoral activation include decreased input from excitatory afferences and increased input from excitatory chemoceptors and metabaroceptor. These phenomena vary to a great extent in different subjects: in the more impaired patients, renal and cardiac overflow of catecholamines can increase three- and ten-fold, respectively, accounting for about 60% of the increase of noradrenaline in congestive heart failure. Efficient methods to quantify sympathetic cardiovascular influences and neuroendocrine indices have been developed and it has been recognized that sympathoneural activation independently predicts the survival of patients. The pathophysiological role and the clinical relevance of neuroadrenergic abnormalities also constitute the grounds for the understanding of the therapeutic benefit obtained with interventions aimed at mitigating the harmful consequences of adrenergic hyperactivity.
Ceconi
C
C
University of Brescia, Spedali Civili, Italy.
Curello
S
S
Ferrari
R
R
D002319:Cardiovascular System / Q000503:physiopathology*; D002395:Catecholamines / Q000502:physiology*; D006333:Heart Failure / Q000503:physiopathology*; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D009490:Neurosecretory Systems / Q000503:physiopathology*; D011379:Prognosis; D013564:Sympathetic Nervous System / Q000503:physiopathology
D002395:Catecholamines