Novel cytotoxic cembranoids from the soft coral Sinularia flexibilis.
Three new cytotoxic cembranoid diterpenes, sinuflexolide (1), dihydrosinuflexolide (2), and sinuflexibilin (3), have been isolated from the soft coral Sinularia flexibilis. The structures of compounds 1-3 were determined by spectral and X-ray crystallographic analysis.
Duh
C Y
CY
Department of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China.
Wang
S K
SK
Tseng
H K
HK
Sheu
J H
JH
Chiang
M Y
MY
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D003063:Cnidaria / Q000737:chemistry*; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D004224:Diterpenes; C113236:dihydrosinuflexolide; C113237:sinuflexibilin; C113235:sinuflexolide