Transcriptional control of cytokine genes.
With antigen stimulation, cytokine genes are coordinately expressed in T cells. However, the optimal signals or helper T cell subset specificity for each cytokine gene expression differ. Mechanisms probably exist that transmit extracellular signals into the nucleus, thereby coordinately turning on and off transcriptional machinery in a signal-specific or cell type-specific manner. We compare here the regulation of cytokine genes and discuss possible mechanisms of coordinated and differential regulation of cytokine genes.
Tsuruta
L
L
Department of Molecular and Developmental Biology, University of Tokyo, Japan.
Arai
N
N
Arai
K
K
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D016207:Cytokines / Q000235:genetics*; D005786:Gene Expression Regulation; D006801:Humans; D008213:Lymphocyte Activation; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000378:metabolism; D018417:Th1 Cells / Q000378:metabolism; D018418:Th2 Cells / Q000378:metabolism; D014158:Transcription, Genetic
D016207:Cytokines; D000242:Cyclic AMP