Anti-retroviral drugs--implications for dental prescribing.
Many patients with HIV/AIDS are now being treated with two or more drugs to reduce HIV viraemia and boost CD4 T-cell counts. Patients are using these drugs earlier in the course of their disease and so GDPs are likely to encounter them in practice. The drugs have dramatically altered short term prognosis but are potent and have potentially serious drug interactions. Some of these drugs have interactions with drugs used in the dental care setting and this paper sets out to summarise those that are relevant in this area.
Greenwood
I
I
Mortimer Market Dental Clinic, Camden Community Health Service NHS Trust, London.
Heylen
R
R
Zakrzewska
J M
JM
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy; D000766:Anesthesia, Dental / Q000009:adverse effects; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000009:adverse effects; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000009:adverse effects; D019380:Anti-HIV Agents / Q000009:adverse effects / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count / Q000187:drug effects; D017742:Dental Care for Chronically Ill; D004347:Drug Interactions; D064420:Drug-Related Side Effects and Adverse Reactions; D015658:HIV Infections / Q000188:drug therapy; D017320:HIV Protease Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage / Q000009:adverse effects; D011379:Prognosis; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D014766:Viremia / Q000188:drug therapy; D014779:Virus Replication / Q000187:drug effects
D018686:Anesthetics, Intravenous; D000779:Anesthetics, Local; D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors; D018894:Reverse Transcriptase Inhibitors; D008012:Lidocaine