Interleukin-10 as a regulatory cytokine induced by cellular stress: molecular aspects.
Interleukin-10 is an ubiquitous cytokine which plays a major regulatory role in the course of inflammatory responses by downregulating the synthesis of cytokines. In this paper, we summarize the major biological properties of IL-10 and the current knowledge of the molecular mechanisms by which IL-10 inhibits the expression of genes encoding proinflammatory cytokines. We then review the factors upregulating IL-10 synthesis and we present the concept that IL-10 is a stress cytokine produced not only in response to microbial pathogens but also to cellular injuries of diverse origins.
Stordeur
P
P
Department of Immunology, Hôpital Erasme, Faculty of Medicine, Université Libre de Bruxelles, Belgium.
Goldman
M
M
D000818:Animals; D016207:Cytokines / Q000096:biosynthesis*; D006801:Humans; D016753:Interleukin-10 / Q000096:biosynthesis* / Q000276:immunology
D016207:Cytokines; D016753:Interleukin-10