title: Intrauterine irrigation with prostaglandin F2-alpha for management of severe postpartum hemorrhage.
abstract: BACKGROUND
  Severe postpartum hemorrhage is a significant contributor to maternal morbidity and mortality. The use of prostaglandin F2-alpha to control severe postpartum hemorrhage may avert surgery for the control of bleeding.
  
  
  METHODS
  After ruling out the possibility of genital tract injuries, 18 patients with severe postpartum hemorrhage caused by uterine atony were enrolled in the study. None of the patients responded to treatment with oxytocin, methylergonovine, or uterine massage. A Foley catheter was introduced into the uterine cavity and the balloon was inflated with 5 ml sterile saline solution. The catheter was connected to an infusion line of 500 ml saline solution containing 20 mg prostaglandin F2-alpha. The solution was infused at a rate of 3-4 ml/minute for the first 10 min, and then reduced to 1 ml/minute for a period of 12 24 hours.
  
  
  RESULTS
  In 17 patients (94.4%) bleeding ceased within several minutes of initiation of intrauterine prostaglandin F2-alpha infusion, the uterus was firmly contracted and uterine bleeding did not recur. In one patient with placenta increta bleeding continued and hysterectomy was performed. None of the patients had any side effects.
  
  
  CONCLUSIONS
  Intrauterine irrigation with low concentrations of prostaglandin F2-alpha is a simple, rapid and effective treatment for severe postpartum hemorrhage and facilitates constant and continuous hemostasis. Moreover, the minute dosage used eludes potentially complicating side effects.
authors.affiliation: Department of Obstetrics and Gynecology, Lis Maternity Hospital, Sackler Faculty of Medicine, Tel Aviv University, Israel.
authors.forename: M J
authors.initials: MJ
authors.lastname: Kupferminc
authors.forename: I
authors.initials: I
authors.lastname: Gull
authors.forename: A
authors.initials: A
authors.lastname: Bar-Am
authors.forename: Y
authors.initials: Y
authors.lastname: Daniel
authors.forename: A
authors.initials: A
authors.lastname: Jaffa
authors.forename: M
authors.initials: M
authors.lastname: Shenhav
authors.forename: J B
authors.initials: JB
authors.lastname: Lessing
mesh_terms: D015237:Dinoprost / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D006473:Postpartum Hemorrhage / Q000188:drug therapy* / Q000209:etiology; D011247:Pregnancy; D007507:Therapeutic Irrigation; D016896:Treatment Outcome; D014593:Uterine Inertia / Q000150:complications; D014599:Uterus
chemical_list: D015237:Dinoprost