title: Asbestos-induced pleural disease.
abstract: Asbestos-induced pleural disease has become the most common manifestation of asbestos exposure. Asbestos has an unusual affinity for the pleural space and leads to plaques, benign effusions, fibrosis, and malignant mesothelioma. The explanation for its affinity for the pleura may lie in part with new evidence showing that asbestos fibers can accumulate in certain regions of the parietal pleura at higher concentrations than in the lung. With the control of industrial exposures to asbestos, the incidence of this disease should decrease, with the incidence of mesothelioma peaking in the years 2000 to 2020. Nonetheless, the toxic features of asbestos including shape, chemical composition, and surface characteristics should be understood to avoid toxicity in fibers used to replace asbestos and to know the risks of low level exposures from asbestos currently in our environment.
authors.affiliation: Department of Pathology, University of California, San Francisco, USA.
authors.forename: S L
authors.initials: SL
authors.lastname: Nishimura
authors.forename: V C
authors.initials: VC
authors.lastname: Broaddus
mesh_terms: D001194:Asbestos / Q000009:adverse effects; D001195:Asbestosis / Q000175:diagnosis* / Q000473:pathology / Q000517:prevention & control; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D006801:Humans; D008654:Mesothelioma / Q000175:diagnosis / Q000473:pathology / Q000517:prevention & control; D010994:Pleura / Q000473:pathology; D010997:Pleural Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000517:prevention & control; D013329:Structure-Activity Relationship; D014057:Tomography, X-Ray Computed
chemical_list: D001194:Asbestos