Effects of voluntary contraction on tibial nerve somatosensory evoked potentials: gating of specific cortical responses.
We evaluated vertex-parietal P37, N50, and contralateral N37 somatosensory evoked potentials (SEPs) to posterior tibial nerve stimulation during weak (20 to 30%) and strong (80 to 90%) ipsilateral gastrocnemius-soleus contraction. The results were compared with data obtained during full relaxation. P37 and N50 were attenuated significantly during weak contraction and then abolished during strong contraction, whereas the contralateral N37 was not. The N37 potential spreads over the vertex and over the ipsilateral parietal region during strong contraction. The Cz'-F3 montage was not appropriate for detecting these SEP patterns. These findings suggest that thalamic or cortical gating mechanisms affect specific cortical responses. P37 and N50 could reflect the arrival of the afferent volley into the motor areas from thalamic and cortical (subareas 1 and 2 of S1) projections. N37 could be generated in subarea 3b. Differential analysis of N37 and P37 is required in clinical practice, mainly in those conditions that involve the motor system and in those conditions in which tonic muscular activity is increased.
Tinazzi
M
M
Department of Neurological and Visual Sciences, Section of Neurology, Verona, Italy.
Fiaschi
A
A
Mauguière
F
F
Manganotti
P
P
Polo
A
A
Bonato
C
C
Zanette
G
G
D000328:Adult; D004558:Electric Stimulation; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D005260:Female; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology*; D008297:Male; D009119:Muscle Contraction / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology; D013003:Somatosensory Cortex / Q000502:physiology*; D013979:Tibial Nerve / Q000502:physiology*