title: Successful treatment with insulin analog lispro in IDDM with delayed absorption of subcutaneously applied human regular insulin and complicated intraperitoneal insulin infusion. A case report.
abstract: OBJECTIVE
  To subcutaneously administer the insulin analog lispro in a patient with delayed absorption of subcutaneously applied human regular insulin whose continuous intraperitoneal insulin infusion (CIPII) with a percutaneous access device had required multiple surgical interventions because of complications.
  
  
  METHODS
  In a 35-year-old woman with long-term IDDM and delayed absorption of subcutaneously applied human regular insulin, a 3-year CIPII with human regular insulin via a percutaneous access device was complicated by three catheter obstructions and one subcutaneous abscess. Each complication required the implantation of a new percutaneous access device. During a 2-day trial with continuous subcutaneous insulin infusion (CSII) of the insulin analog lispro at basal infusion rates of 0.5-1.1 U/h, stable metabolic control was achieved. A 5-h intermediate attempt with human regular insulin in CSII, however, increased blood glucose concentrations from 6.0 to 28.8 mmol/l, despite identical basal rates and additional injection of 16 U of human regular insulin. Restarting with CSII of the insulin analog lispro reinforced stable metabolic control.
  
  
  CONCLUSIONS
  It is suggested that the insulin analog lispro is a promising approach in the treatment of IDDM with delayed absorption of subcutaneously applied human regular insulin and a suitable alternative therapy for patients with complications attributed to percutaneous access devices for CIPII.
authors.affiliation: Diabetes Research Institute, Schwabing Hospital, Munich, Germany. meierm@joslab.harvard.edu
authors.forename: M
authors.initials: M
authors.lastname: Meier
authors.forename: J
authors.initials: J
authors.lastname: Brand
authors.forename: E
authors.initials: E
authors.lastname: Standl
authors.forename: O
authors.initials: O
authors.lastname: Schnell
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007263:Infusions, Parenteral / Q000009:adverse effects; D007328:Insulin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D007332:Insulin Infusion Systems / Q000009:adverse effects; D061268:Insulin Lispro; D007408:Intestinal Absorption; D008297:Male; D013997:Time Factors
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin; D061268:Insulin Lispro