The correlation between coronary stenosis index and flow-mediated dilation of the brachial artery.
We examined the relationship between flow-mediated dilation (FMD) of the brachial artery and the extent and severity of coronary artery disease (CAD). Using high-resolution ultrasonography, we measured FMD and nitroglycerin-induced brachial artery dilation. We studied 121 patients (77 men, 44 women; mean age 64+/-11 years, range 25-79 years) who underwent coronary arteriography. The extent and severity of CAD were assessed by the coronary stenosis index (CSI). The adjusted FMD correlated inversely with CSI (rs=-0.63, p<0.0001). Multivariate analysis demonstrated that the adjusted FMD was an independent predictor of CSI. The adjusted FMD was 10.2+/-4.8% in patients without CAD (n=32), 7.7+/-6.0% in patients with single-vessel disease (n=31), 5.2+/-5.5% in patients with double-vessel disease (n=29), and 2.0+/-3.9% in patients with triple-vessel disease (n=29). The adjusted FMD was significantly lower in the double- (p<0.01) and triple-vessel (p<0.0001) disease groups than in patients without CAD. The adjusted FMD was significantly lower in the triple-vessel disease group than in the single-vessel disease group (p<0.001). Based on our results, as coronary atherosclerosis becomes more severe, the adjusted brachial artery FMD becomes more severely impaired.
Kaku
B
B
Fukui Cardiovascular Center, Japan.
Mizuno
S
S
Ohsato
K
K
Murakami
T
T
Moriuchi
I
I
Arai
Y
Y
Nio
Y
Y
Hirase
H
H
Nagata
M
M
Takahashi
Y
Y
Ohnaka
M
M
D000328:Adult; D000368:Aged; D000789:Angina, Unstable / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000503:physiopathology; D003327:Coronary Disease / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology*; D003329:Coronary Vasospasm / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology; D003920:Diabetes Mellitus / Q000453:epidemiology; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006940:Hyperemia / Q000209:etiology / Q000503:physiopathology; D006949:Hyperlipidemias / Q000453:epidemiology; D006973:Hypertension / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin; D009765:Obesity / Q000453:epidemiology; D012039:Regional Blood Flow; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology; D014463:Ultrasonography; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*; D014665:Vasodilator Agents
D014665:Vasodilator Agents; D005996:Nitroglycerin