title: [TNF-alpha preactivation (priming) of neutrophils--effect on selected neutrophil functions].
abstract: Human polymorphonuclear cells (neutrophils) are fundamentally protective, but extracellular release of proteolytic enzymes and oxygen radicals may lead to tissue destruction. Granulocyte function can be rapidly amplified by environmental factors through a mechanism termed "priming". Priming enhances the neutrophils' ability to respond to a secondary agonist, with increased adhesion, respiratory burst, and degranulation. This review summarizes the effects of TNF-alpha priming on the neutrophils' function.
authors.affiliation: Zakład Patofizjologii Katedry Nauk Patofizjologicznych Wojskowej Akademii Medycznej w Lodzi.
authors.forename: J
authors.initials: J
authors.lastname: Paśnik
mesh_terms: D002448:Cell Adhesion / Q000502:physiology; D002633:Chemotaxis / Q000502:physiology; D006801:Humans; D018375:Neutrophil Activation / Q000502:physiology*; D010586:Phagocytes / Q000378:metabolism; D016897:Respiratory Burst / Q000502:physiology; D015398:Signal Transduction; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D014409:Tumor Necrosis Factor-alpha
vernacular_title: Preaktywacja (priming) neutrofila przez TNF-alpha--wpływ na wybrane funkcje neutrofila.