[Distribution of clozapine in poisoned rabbits].
The distribution of clozapine in the body of rabbits died of poison was studied by the method of TLC. The concentration of clozapine in blood, urine, bile, livers, kidneys, spleen, lungs, hearts and brains were 19.4 +/- 6.9, 50.2 +/- 12.6, 75.9 +/- 12.5, 25.9 +/- 4.0, 34.0 +/- 4.7, 13.3 +/- 2.2, 20.0 +/- 4.3, 5.0 +/- 2.3 and 43.6 +/- 43.4 ug/ml or ug/g.respectively. It is concluded that the Clozapine be not well-distributed in poisoned rabbits, Blood, bile, urine, liver and spleen are better samples for the analysis of clozapine than others.
Yun
K
K
Department of Forensic Medicine, Shanxi Medical University.
Li
G
G
D000818:Animals; D014150:Antipsychotic Agents / Q000493:pharmacokinetics* / Q000633:toxicity; D003024:Clozapine / Q000493:pharmacokinetics* / Q000633:toxicity; D011817:Rabbits; D014018:Tissue Distribution
D014150:Antipsychotic Agents; D003024:Clozapine