A first and straightforward approach to detection limits for narrow-bore HPLC and CE.
Two methodologies have been proposed for a simple statistical estimation of the detection limits in microbore-HPLC and CE techniques. Due to the impossibility to measure the blank, by using the extrapolated or approximated expressions it is possible to obtain a straightforward approach of the detection limits from the study of the residuals of the calibration data set, avoiding tedious treatment of the signals. The utility of these expressions has been checked on the data from an experimental microbore HPLC system.
García Campaña
A M
AM
Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Spain.
Baeyens
W R
WR
Van der Weken
G
G
Cuadros Rodríguez
L
L
Alés Barrero
F
F
D002138:Calibration; D002851:Chromatography, High Pressure Liquid / Q000379:methods / Q000706:statistics & numerical data*; D019075:Electrophoresis, Capillary / Q000379:methods / Q000706:statistics & numerical data*