title: Comparative assessment of hepatic Glisson's capsule and bovine pericardium in heart valve bioprostheses.
abstract: OBJECTIVE
  The optimal material for heart valve bioprostheses remains disputable. This investigation was initiated to compare the properties of hepatic Glisson's capsule, clinical experience of which in cardiovascular surgery is minimal, with those of bovine pericardium.
  
  
  METHODS
  Hepatic Glisson's capsule was harvested from bull calves and used to create composite pulmonary arterial monocusp grafts and bioprostheses. Comparison of the strength and elastic properties of Glisson's capsule and bovine pericardium, as well as the hydrodynamic characteristics of valves made from these materials, was performed. Late results of operations using these materials were estimated echocardiographically.
  
  
  RESULTS
  Although Glisson's capsule tissue is thinner than the bovine pericardium, its elasticity modulus is greater. However, the hydrodynamic characteristics of heart valves made from either tissue are similar. Moreover, valves made from Glisson's capsule have a lower systolic pressure gradient on the prosthesis and a higher effective orifice area. Composite pulmonary arterial xenopericardial grafts with a monocusp of Glisson's capsule were used in 30 patients during tetralogy of Fallot repair. Glisson's capsule was also used for tricuspid valve reconstruction and as a bioprosthesis in six patients with Ebstein's anomaly. At 1-2 years after surgery, the Glisson's capsule tissue remained thin and flexible, with no calcification.
  
  
  CONCLUSIONS
  Although the hydrodynamic properties of hepatic Glisson's capsule and the bovine pericardium are similar, the capsule tissue is thinner and has a greater elasticity modulos. Thus, Glisson's capsule may be used for bioprosthesis construction both independently and in combination with bovine pericardium.
authors.affiliation: Bakoulev Scientific Center for Cardiovascular Surgery, Moscow, Russia.
authors.forename: I I
authors.initials: II
authors.lastname: Kagramanov
authors.forename: I V
authors.initials: IV
authors.lastname: Kokshenev
authors.forename: N B
authors.initials: NB
authors.lastname: Dobrova
authors.forename: V T
authors.initials: VT
authors.lastname: Kastava
authors.forename: R A
authors.initials: RA
authors.lastname: Serov
authors.forename: S B
authors.initials: SB
authors.lastname: Zaets
mesh_terms: D000818:Animals; D001705:Bioprosthesis; D002417:Cattle; D004437:Ebstein Anomaly / Q000601:surgery; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008099:Liver / Q000033:anatomy & histology; D008297:Male; D010496:Pericardium / Q000637:transplantation; D011474:Prosthesis Design; D051381:Rats; D017208:Rats, Wistar; D013771:Tetralogy of Fallot / Q000601:surgery