title: Malignant lymphoma demonstrating sick sinus syndrome.
abstract: We report a case of T-cell-rich large B-cell lymphoma demonstrating sick sinus syndrome as a single initial symptom, followed by the retention of pericardial and pleural effusions. Intrapleural administration of interferon-alpha prevented reaccumulation of the pleural effusion for one and a half months, whereas systemic chemotherapy failed to control tumor growth in the skin and lymph nodes. The autopsy revealed involvement of the sinoatrial node of the heart by lymphoma cells.
authors.affiliation: Pulmonology Department, International Medical Center of Japan, Tokyo.
authors.forename: M
authors.initials: M
authors.lastname: Kamimura
authors.forename: N
authors.initials: N
authors.lastname: Tanabe
authors.forename: M
authors.initials: M
authors.lastname: Hojo
authors.forename: T
authors.initials: T
authors.lastname: Horiuchi
authors.forename: K
authors.initials: K
authors.lastname: Kudo
authors.forename: K
authors.initials: K
authors.lastname: Saitoh
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use; D004562:Electrocardiography; D017809:Fatal Outcome; D006338:Heart Neoplasms / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D010490:Pericardial Effusion / Q000175:diagnosis / Q000628:therapy; D010996:Pleural Effusion / Q000175:diagnosis / Q000628:therapy; D012804:Sick Sinus Syndrome / Q000175:diagnosis* / Q000628:therapy; D012849:Sinoatrial Node / Q000473:pathology*; D013601:T-Lymphocytes / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D016898:Interferon-alpha