[Myofibroblastic tumors. Brief review of clinical aspects, diagnosis and differential diagnosis].
This review summarizes myofibroblastic tumours that have been characterized in the last years. These lesions include: fibromatoses in adults and infants (infantile digital fibromatosis and infantile myofibromatosis); myofibroma of adults, an almost exclusively solitary lesion in the skin which is characterized morphologically as a biphasic lesion composed of spindle-shaped eosinophilic tumour cells and more primitive mesenchymal tumour cells associated with a haemangiopericytoma-like vasculature; dermatomyofibroma (plaque-like dermal fibromatosis), a band-like myofibroblastic proliferation in young female patients, which is mainly located in the periaxillar region and in which distinction from more aggressive, plaque-like variant of dermatofibrosarcoma protuberans is mandatory; myofibroblastoma of the breast, a well-circumscribed lesion composed of spindle shaped, desmin-positive tumour cells, which is seen mainly in elderly male patients and has to be distinguished from other spindle cell lesions of the breast; angiomyofibroblastoma, a well-circumscribed myofibroblastic neoplasm of the vulva and vagina composed of avoid to round myoid tumour cells with scattered multinucleated cells, which forms a continuous morphological spectrum with the clinically more aggressive angiomyxoma in this location; intranodal myofibroblastoma, a distinctive proliferation of myofibroblastic cells associated with so-called amianthoid fibres, which is seen most commonly in inguinal lymph nodes; myofibroblastoma/myofibroblastic tumour of soft tissues, a variably well-circumscribed myofibroblastic lesion which lacks atypia and is composed of actin and/or desmin positive tumour cells, and poorly delineated sarcomas with myofibroblastic differentiation (myofibrosarcoma).
Mentzel
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T
Institut für Pathologie der Friedrich-Schiller-Universität, Jena.
Katenkamp
D
D
D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D018222:Desmoid Tumors / Q000473:pathology*; D006801:Humans; D007223:Infant; D007889:Leiomyoma / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D018224:Myofibromatosis / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000473:pathology*
D014408:Biomarkers, Tumor
Myofibroblastäre Tumoren. Kurzgefasste Ubersicht zur Klinik, Diagnose und Differentialdiagnose.