Two (Z)-dehydrobutyrine-containing microcystins from a hepatotoxic bloom of Oscillatoria agardhii from Soulseat Loch, Scotland.
Two (Z)-dehydrobutyrine(Dhb)-containing microcystins, [d-Asp3, (Z)-Dhb7]microcystin-HtyR (1) and [d-Asp3, (Z)-Dhb7]microcystin-LR (2), were isolated from a hepatotoxic bloom of the cyanobacterium Oscillatoria agardhii from a freshwater lake in Scotland. The geometrical structure of the Dhb units in the microcystins was determined as Z on the basis of NOE and ROESY experiments.
Sano
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Environmental Chemistry Division, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-0053, Japan. sanotomo@nies.go.jp
Beattie
K A
KA
Codd
G A
GA
Kaya
K
K
D002240:Carbohydrate Sequence; D056486:Chemical and Drug Induced Liver Injury; D000458:Cyanobacteria / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D052998:Microcystins; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification*; D012606:Scotland; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D052998:Microcystins; D010456:Peptides, Cyclic; C113240:microcystin-HtyR, Asp(3)-Dhb(7)-; C113241:microcystin-LR, Asp(3)-Dhb(7)-