Ischemia/reperfusion injury in flow-through venous flaps.
The effects of ischemia/reperfusion (I/R) injury in flow-through venous flaps were evaluated in rabbits. The rates of flap survival and the levels of lipid peroxidation, protein oxidation, and sulfhydryl groups were compared between flow-through venous flaps, conventional flaps after an I/R period (experimental groups), and flow-through venous flaps without being subjected to I/R injury (control groups) in 20 animals. On the seventh day after the onset of reperfusion, 3 of 10 flow-through venous flaps (30%) and 6 of 10 arteriovenous flaps (60%) survived in the experimental groups. Flow-through venous flaps showed a decreased survival rate compared with control and conventional flaps (p < 0.05). Tissue lipid peroxide levels were found to be higher in venous flaps during reperfusion after secondary ischemia (p < 0.05). Tissue protein oxidation and total sulfhydryl groups levels did not show any difference among groups. This study suggests that more free radical damage occurs in flow-through venous flaps during I/R injury.
Atabey
A
A
Department of Plastic and Reconstructive Surgery, School of Medicine, Dokuz Eylül University, Izmir, Turkey.
Gezer
S
S
Vayvada
H
H
Kirkali
G
G
Menderes
A
A
Karaca
C
C
Barutçu
A
A
D000818:Animals; D015227:Lipid Peroxidation; D009336:Necrosis; D011817:Rabbits; D015427:Reperfusion Injury / Q000503:physiopathology*; D013524:Surgical Flaps / Q000098:blood supply* / Q000473:pathology / Q000502:physiology