title: Sasanquol, a 3,4-seco-triterpene alcohol from sasanqua oil, and its anti-inflammatory effect.
abstract: A novel 3,4-seco-triterpene alcohol, named sasanquol, was isolated from the non-saponifiable lipid of sasanqua oil from the seeds of Camellia sasanqua. Its structure was established to be 3,4-seco-D:B-friedobacchara-4,21-dien-3-ol by spectroscopic methods. This is the first example of naturally occurring triterpene with a D:B-friedobaccharane skeleton. The 50% inhibitory dose of this compound against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear inflammation (1 microgram per ear) in mice was 0.4 mg per ear.
authors.affiliation: College of Science and Technology, Nihon University, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Akihisa
authors.forename: K
authors.initials: K
authors.lastname: Yasukawa
authors.forename: Y
authors.initials: Y
authors.lastname: Kimura
authors.forename: S
authors.initials: S
authors.lastname: Yamanouchi
authors.forename: T
authors.initials: T
authors.lastname: Tamura
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D007249:Inflammation / Q000188:drug therapy; D051379:Mice; D010938:Plant Oils / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry; D013662:Tea / Q000737:chemistry*; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D010938:Plant Oils; D013662:Tea; D014315:Triterpenes; C112978:sasanquol