title: A systematic study of the lactate lineshape in PRESS-localized proton spectroscopy.
abstract: J-coupled resonances such as lactate exhibit complex behavior in PRESS-localized spectroscopy. Polarization transfer effects due to nonideal slice profiles can lead to substantial errors in quantification unless recognized. In this work, it is shown how these effects can be predicted in a systematic way given the sequence timing and the RF pulse envelopes. Experimental results are presented to highlight the problems of working at the popular echo time of 2/J.
authors.affiliation: Department of Medical Physics and Medical Engineering, University of Edinburgh, United Kingdom.
authors.forename: I
authors.initials: I
authors.lastname: Marshall
authors.forename: J
authors.initials: J
authors.lastname: Wild
mesh_terms: D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D019344:Lactic Acid / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods*; D008961:Models, Structural; D019047:Phantoms, Imaging; D011522:Protons; D012680:Sensitivity and Specificity
chemical_list: D011522:Protons; D019344:Lactic Acid