title: About 8-hour variation of circulating human endothelin-1.
abstract: Plasma endothelin-1 (ET-1) and cortisol were measured around the clock at hourly intervals on 7 clinically healthy, diurnally active, nocturnally resting subjects 22-27 years of age. The circadian rhythm in cortisol is demonstrated for each subject (p < or = 0.020) as well as on a group basis (p = 0.002), peaking in the morning. By contrast, the circadian variation of ET-1 is statistically significant in only one of the subjects, and it is not detected for the group as a whole (p > 0.20). Instead, ET-1 is characterized by an about 8-h component (p < 0.001) that is not found for cortisol.
authors.affiliation: Universitäts-Klinik für Innere Medizin, Innsbruck, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Herold
authors.forename: G
authors.initials: G
authors.lastname: Cornélissen
authors.forename: A
authors.initials: A
authors.lastname: Loeckinger
authors.forename: D
authors.initials: D
authors.lastname: Koeberle
authors.forename: P
authors.initials: P
authors.lastname: Koenig
authors.forename: F
authors.initials: F
authors.lastname: Halberg
mesh_terms: D000328:Adult; D002940:Circadian Rhythm / Q000502:physiology*; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D012016:Reference Values
chemical_list: D019332:Endothelin-1; D006854:Hydrocortisone