The immunomodulator OM-89 induces ACTH and glucocorticoid secretion in rats through an IL-1 dependent pathway.
The immunomodulator OM-89 (bacterial extract from E. coli), known to act on the immune system by modulating both humoral and cellular responses, significantly increases ACTH and glucocorticoids secretion in normal Wistar rats. A comparative administration of IL-1 displays a similar pattern of release. Moreover, OM-89-induced responses are blocked by IL-1ra, the soluble receptor antagonist of IL-1. The effect of OM-89 can thus be explained, at least in part, via IL-1 which directly enhances the secretion of both stress hormones. Finally, a comparative experiment between control and stressed rats (by immobilization) shows that the responses to OM-89 measured in this study (ACTH and corticosterone secretion) are stress-modulated.
Mimouni
J
J
Laboratory of Cell Physiology, University Claude Bernard Lyon-1, Villeurbanne, France.
Farine
J C
JC
Melhaoui
A
A
Fontanges
R
R
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000818:Animals; D000942:Antigens, Bacterial / Q000494:pharmacology*; D003345:Corticosterone / Q000378:metabolism*; D004702:Endocrine Glands / Q000187:drug effects / Q000276:immunology / Q000502:physiology; D007103:Immobilization; D007107:Immune System / Q000187:drug effects / Q000502:physiology; D007375:Interleukin-1 / Q000494:pharmacology / Q000502:physiology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000276:immunology / Q000503:physiopathology
D000276:Adjuvants, Immunologic; D000942:Antigens, Bacterial; D007375:Interleukin-1; C050501:OM 89; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone