Antiischemic effect of ZK-118.182 in rabbits: a comparative study with iloprost.
The effects of ZK-118.182, a stable analogue of PGD2, were evaluated in an endothelin-1-induced cerebral ischemia rabbit model. Ischemia was induced by endothelin-1 injection (0.25 ng bolus) into subcavian artery and ischemic changes were assessed histologically by the number of ischemic neurons in the brain stem. ZK-118.182 (2 micrograms/kg, bolus into subclavian artery) reduced the number of ischemic neurons when injected 20 min after endothelin-1 injection, Iloprost, a stable analogue of PGI2, was also effective in reducing the number of ischemic neurons in a dose of 0.5 microgram/kg (bolus into subclavian artery). The results suggested that ZK-118.182 has a potent antiischemic effect which is comparable to that of iloprost in rabbits.
Akarsu
E S
ES
Faculty of Medicine, Department of Pharmacology & Clinical Pharmacology, University of Ankara, Turkey. akarsu@dialup.ankara.edu.tr
Keskil
S
S
Kaymaz
M
M
Uysal
S
S
Ceviker
N
N
Ataoglu
O
O
Baykaner
K
K
D000818:Animals; D002545:Brain Ischemia / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000494:pharmacology; D004195:Disease Models, Animal; D019332:Endothelin-1 / Q000633:toxicity; D016285:Iloprost / Q000494:pharmacology*; D009474:Neurons / Q000473:pathology; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011817:Rabbits
D019332:Endothelin-1; D010975:Platelet Aggregation Inhibitors; C067426:ZK 118182; D015237:Dinoprost; D016285:Iloprost