title: Diabetic patients produce an increase in coronary sinus endothelin 1 after coronary artery bypass grafting.
abstract: Diabetes is associated with altered vascular responses, and diabetic patients demonstrate increased morbidity and mortality after coronary artery bypass grafting (CABG). We tested whether endothelin (ET)-1 levels in this patient population differed from those in nondiabetic subjects after CABG. Of 14 consecutive patients who underwent CABG by the same surgeon, 7 had type 2 diabetes and 7 were nondiabetic. The two groups did not differ significantly in preoperative ejection fraction, number of vessels bypassed, cross-clamp time, or Parsonnet's score. Coronary sinus blood samples were obtained before cardioplegic arrest and then obtained at 1 and 15 min after each of two reperfusion periods: reperfusion A (native coronary perfusion plus the left internal mammary artery), reperfusion B (saphenous vein graft perfusion). ET-1 was significantly increased at all reperfusion time points in diabetic patients compared with nondiabetic patients. In diabetic patients, reperfusion after CABG can trigger the release of ET-1, which may be a contributing factor in the increased cardiac morbidity seen in this patient population.
authors.affiliation: Department of Surgery, University of Illinois at Chicago College of Medicine, 60612, USA.
authors.forename: B G
authors.initials: BG
authors.lastname: Fogelson
authors.forename: S I
authors.initials: SI
authors.lastname: Nawas
authors.forename: W T
authors.initials: WT
authors.lastname: Vigneswaran
authors.forename: J L
authors.initials: JL
authors.lastname: Ferguson
authors.forename: W R
authors.initials: WR
authors.lastname: Law
authors.forename: A C
authors.initials: AC
authors.lastname: Sharma
mesh_terms: D001026:Coronary Artery Bypass; D003331:Coronary Vessels / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D019332:Endothelin-1 / Q000096:biosynthesis*; D006324:Heart Arrest, Induced; D006801:Humans; D008875:Middle Aged
chemical_list: D019332:Endothelin-1