title: Predictive value of plasma thrombomodulin in preeclampsia and gestational hypertension.
abstract: In a prospective longitudinal study, 130 primigravidae at risk for preeclampsia were examined and plasma sampling performed in 45 of them. Plasma thrombomodulin (pTM) was sequentially measured at weeks 12, 24 and 32 of gestation and after delivery in 20 primigravidae who developed either mild preeclampsia (n = 8) or gestational hypertension (n = 12) between weeks 32 and 39 of gestation and in 25 (age-matched) primigravidae who had uneventful pregnancies. pTM elevations were not observed until week 32 in uneventful pregnancies, but were present by week 24 (p = 0.002) in patients who later developed hypertensive complications. A net individual pTM increase > or = 4.2 ng/ml between weeks 12 and 24 (more than 8 times that of normotensive primigravidae) and/or pTM level > or = 47.5 ng/ml at week 32 predicted the development of hypertensive complications with 80% accuracy. Serial pTM determinations can be useful to select pregnancies who may benefit from early pharmacological intervention.
authors.affiliation: INSERM Unité 353, Hôpital Saint-Louis, Paris, France.
authors.forename: M C
authors.initials: MC
authors.lastname: Boffa
authors.forename: L
authors.initials: L
authors.lastname: Valsecchi
authors.forename: A
authors.initials: A
authors.lastname: Fausto
authors.forename: D
authors.initials: D
authors.lastname: Gozin
authors.forename: S
authors.initials: S
authors.lastname: Vigano' D'Angelo
authors.forename: O
authors.initials: O
authors.lastname: Safa
authors.forename: M T
authors.initials: MT
authors.lastname: Castiglioni
authors.forename: J
authors.initials: J
authors.lastname: Amiral
authors.forename: A
authors.initials: A
authors.lastname: D'Angelo
mesh_terms: D000328:Adult; D015415:Biomarkers; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007677:Kidney Function Tests; D011225:Pre-Eclampsia / Q000097:blood* / Q000453:epidemiology; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D011264:Pregnancy Trimesters / Q000097:blood*; D011446:Prospective Studies; D012372:ROC Curve; D012307:Risk Factors; D018180:Thrombomodulin / Q000097:blood*
chemical_list: D015415:Biomarkers; D018180:Thrombomodulin; D003404:Creatinine