title: [Use of hypoprothrombinemia provocation test for early diagnosis of liver disease caused by harmful environmental agents].
abstract: The aim of this work has been to assess the feasibility of using Prothrombin Time (PT) Assay before and after administration of Pelentan (Hypoprothrombinemia Provocation (HPP) Test) for early detection of subclinical toxic hepatic injuries. The proposed modification of PT Assay is based on the observation that people with slight hepatic injury receiving small doses of Pelentan (diethylcoumarol) display remarkably longer PT than healthy people receiving similar doses of the chemical. The test group comprised 37 people occupationally exposed to hepatotoxic agents, 85 males permanently abusing alcohol, while 24 clinically healthy people, not exposed occupationally to the toxic agents served as the control. In addition, 26 hepatitis B and/or C virus carriers were also examined. The results show that: 1. HPP test enables assessment of hepatic function in patients with suspected hepatic injury and in people permanently abusing alcohol; 2. low value of serum prothrombin index 24 h and 48 h after the administration of Pelentan is indicative of the positive result of the test; 3. HPP test provides more information on the functional condition of liver than single PT determination by the Quick assay.
authors.affiliation: Zakładu Diagnostyki Laboratoryjnej Instytutu Medycyny Pracy, Lodzi.
authors.forename: M
authors.initials: M
authors.lastname: Prazanowski
authors.forename: B
authors.initials: B
authors.lastname: Piłacik
authors.forename: W
authors.initials: W
authors.lastname: Lutz
mesh_terms: D000328:Adult; D000368:Aged; D000395:Air Pollutants, Occupational / Q000009:adverse effects*; D000437:Alcoholism / Q000150:complications; D000925:Anticoagulants / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury; D004784:Environmental Monitoring / Q000379:methods; D005017:Ethyl Biscoumacetate / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007020:Hypoprothrombinemias / Q000175:diagnosis* / Q000209:etiology; D008107:Liver Diseases / Q000150:complications / Q000175:diagnosis*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011517:Prothrombin Time
chemical_list: D000395:Air Pollutants, Occupational; D000925:Anticoagulants; D005017:Ethyl Biscoumacetate
vernacular_title: Zastosowanie próby hipoprotrombinemii prowokowanej we wczesnej diagnostyce chorób watroby wywołanych przez czynniki środowiskowe.