title: [Antiedema activity of selected compounds with a gallate skeleton].
abstract: Using rat paw dextran-induced and carrageenan-induced edemas, the anti-inflammatory activity of gallic acid (I), triacetylgallic acid (II) and monohydrate copper(II) triacetylgallate (III) was assayed. All compounds tested were applied i.p. in a single dose of 50 mumol/kg body weight, calculated for the RCOO-fragment. The average antiedematous activities in dextran/carrageenan edemas were decreasing in the following order: III (55.9/41.8%) > I (38.6/31.1%) > II (-3.4/13.3%). The relationship between the biological effects found and gallic acid as well as its structural derivatives is discussed.
authors.affiliation: Katedra chemickej teórie lieciv Farmaceutickej fakulty Univerzity Komenského, Bratislava.
authors.forename: J
authors.initials: J
authors.lastname: Sokolík
authors.forename: K
authors.initials: K
authors.lastname: Karovicová
authors.forename: I
authors.initials: I
authors.lastname: Tumová
authors.forename: M
authors.initials: M
authors.lastname: Blahová
authors.forename: P
authors.initials: P
authors.lastname: Svec
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002351:Carrageenan; D003911:Dextrans; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005707:Gallic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use*; D051379:Mice; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000893:Anti-Inflammatory Agents; D003911:Dextrans; D005707:Gallic Acid; D002351:Carrageenan
vernacular_title: Antiedematózna aktivita vybraných zlúcenín s galátovým skeletom.