title: Cardiac sarcoidosis mimicking hypertrophic cardiomyopathy: clinical utility of radionuclide imaging for differential diagnosis.
abstract: A 62-year-old woman with skin sarcoidosis was admitted to our hospital to ascertain whether she had cardiac involvement. Although she displayed no cardiac signs or symptoms, the electrocardiogram showed first-degree atrioventricular block, right bundle branch block with left anterior fascicular block, and giant negative T waves in the V3 lead. Echocardiography revealed marked hypertrophy localized in the basal portion of the interventricular septum (IVS) without systolic dysfunction, mimicking hypertrophic cardiomyopathy (HCM). Exercise thallium-201 myocardial imaging revealed redistribution in the anteroseptal region. Both gallium-67 (67Ga) and technetium-99m pyrophosphate (99mTc-PYP) scintigraphy revealed abnormal uptake in the myocardium. These findings disappeared after 2 months of steroid treatment. Reports of cardiac sarcoidosis mimicking HCM are rare. However, hypertrophy in the basal portion of the IVS is an important sign of early cardiac involvement in sarcoidosis. 67Ga and 99mTc-PYP scintigraphy were useful and necessary to differentiate this type of cardiac sarcoidosis from HCM.
authors.affiliation: First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Yazaki
authors.forename: M
authors.initials: M
authors.lastname: Isobe
authors.forename: M
authors.initials: M
authors.lastname: Hayasaka
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: T
authors.initials: T
authors.lastname: Fujii
authors.forename: M
authors.initials: M
authors.lastname: Sekiguchi
mesh_terms: D009202:Cardiomyopathies / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D002312:Cardiomyopathy, Hypertrophic / Q000175:diagnosis* / Q000000981:diagnostic imaging; D003937:Diagnosis, Differential; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D005710:Gallium Radioisotopes; D006327:Heart Block / Q000209:etiology; D006801:Humans; D008875:Middle Aged; D011877:Radionuclide Imaging; D012507:Sarcoidosis / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D016698:Technetium Tc 99m Pyrophosphate; D013794:Thallium Radioisotopes
chemical_list: D005710:Gallium Radioisotopes; D013794:Thallium Radioisotopes; D016698:Technetium Tc 99m Pyrophosphate