title: Prevalence of Wernicke-Korsakoff syndrome in Australia: has thiamine fortification made a difference?
abstract: OBJECTIVE
  To determine the prevalence of the Wernicke-Korsakoff syndrome (WKS) in Australia and compare this with previous studies.
  
  
  METHODS
  Prospective autopsy study at the New South Wales Institute of Forensic Medicine, 1996-1997.
  
  
  METHODS
  Brains of deceased people (aged over 15 years) derived from 2212 sequential autopsies performed between 1 January 1996 and 31 December 1997 were studied macroscopically and microscopically to identify cases of WKS.
  
  
  METHODS
  Standard histological criteria for WKS and any available clinical data.
  
  
  RESULTS
  Twenty-five cases of WKS were identified (prevalence, 1.1%), mostly among the 5.9% of the 2212 people who had a history suggestive of alcohol abuse. Only four cases (16%) had been diagnosed during life.
  
  
  CONCLUSIONS
  There has been a significant reduction in the prevalence of WKS in Australia since the introduction of thiamine enrichment of bread flour. While the prevalence is still higher than in most other Western countries, further research is needed before adding thiamine to alcoholic beverages can be recommended.
authors.affiliation: Department of Pathology, University of Sydney, NSW. cliveh@pathology.su.oz.au
authors.forename: C G
authors.initials: CG
authors.lastname: Harper
authors.forename: D L
authors.initials: DL
authors.lastname: Sheedy
authors.forename: A I
authors.initials: AI
authors.lastname: Lara
authors.forename: T M
authors.initials: TM
authors.lastname: Garrick
authors.forename: J M
authors.initials: JM
authors.lastname: Hilton
authors.forename: J
authors.initials: J
authors.lastname: Raisanen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000150:complications; D001315:Australia / Q000453:epidemiology; D001344:Autopsy; D001515:Beer; D001921:Brain / Q000473:pathology*; D001939:Bread; D005260:Female; D005527:Food, Fortified; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D013831:Thiamine / Q000008:administration & dosage*; D014899:Wernicke Encephalopathy / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control*
chemical_list: D013831:Thiamine