Analysis of HLA-DPB1 polymorphisms in African-Americans with sarcoidosis.
Several studies have found weak associations between certain human leukocyte antigen (HLA) alleles and sarcoidosis, but none have been conclusive. Glutamic acid at position 69 in HLA-DPB1 has been reported to be strongly associated with chronic beryllium disease. The immunopathologic and clinical similarities between chronic beryllium disease (CBD) and sarcoidosis suggest that similar immune-response genes may be involved in susceptibility in both diseases. We analyzed the DNA sequence of HLA-DPB1 exon 2, which contains the hypervariable regions involved in binding antigens, in blood samples from African-American sarcoidosis patients and healthy controls. Results indicate that Val36 (odds ratio [OR] = 2.30) and Asp55 (OR = 2.03) are associated with increased risk for sarcoidosis, but no association with Glu69 was found. These results suggest that although HLA-DPB1 Glu69 is not associated with sarcoidosis, other alleles may make some contribution to susceptibility to sarcoidosis in African-Americans.
Maliarik
M J
MJ
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, and Department of Biostatistics and Research Epidemiology, Henry Ford Health Sciences Center, Detroit, Michigan, USA.
Chen
K M
KM
Major
M L
ML
Sheffer
R G
RG
Popovich
J
J
Rybicki
B A
BA
Iannuzzi
M C
MC
D000328:Adult; D000368:Aged; D000483:Alleles; D044383:Black People / Q000235:genetics*; D005260:Female; D006682:HLA-DP Antigens / Q000235:genetics*; D006801:Humans; D007135:Immunoglobulin Variable Region; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic; D017565:Sarcoidosis, Pulmonary / Q000208:ethnology / Q000235:genetics*; D017422:Sequence Analysis, DNA; D001741:Black or African American
D006682:HLA-DP Antigens; D007135:Immunoglobulin Variable Region