[Dual reciprocal regulation of the succinate oxidation system in heart and liver mitochondria in pathological conditions].
The phenomenon of the dual reciprocal regulation of succinate dependent 2H+/Ca2+ exchange was studied in heart and liver mitochondria of experimental animals (allogenic heart transplantation in rat; myocardium infarction in rabbits; pulmonary arteria coarctation in dogs) and in liver bioptates from patients with stomach ulcer. Under pathology two coupled but opposite changes (simultaneous activation and inhibition) in succinate dependent Ca2+ transport occur. The inhibition of Ca2+ transport was detected by its elimination with glutamate, being mostly pronounced after cycle of ADP phosphorylation added to suspension of mitochondria. The treatment of animal with 2-oxoglutarate abolished this inhibition. This was not observed in healthy animals. The described phenomenon can prevent hyperactivation of succinate oxidation under strong pathological (distress) influences.
Saakian
I R
IR
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow region, Russia.
Saakian
A G
AG
D000818:Animals; D017920:Antiporters / Q000378:metabolism; D001157:Arterial Occlusive Diseases / Q000378:metabolism*; D001706:Biopsy; D002118:Calcium / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000378:metabolism; D027682:Cation Transport Proteins; D004195:Disease Models, Animal; D004285:Dogs; D016027:Heart Transplantation; D006801:Humans; D017136:Ion Transport; D008929:Mitochondria, Heart / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000378:metabolism*; D009203:Myocardial Infarction / Q000378:metabolism*; D010084:Oxidation-Reduction; D011651:Pulmonary Artery / Q000473:pathology; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D019802:Succinic Acid / Q000378:metabolism*
D017920:Antiporters; D002135:Calcium-Binding Proteins; D027682:Cation Transport Proteins; C027614:calcium-hydrogen antiporters; D019802:Succinic Acid; D002118:Calcium
Dvoĭnaia retsiproknaia reguliatsiia sistemy okisleniia suktsinata v mitokhondriiakh serdtsa i pecheni v usloviiakh patologii.