title: [Cardiac accidents of locoregional anesthesia: experimental study of risk factors with bupivacaine].
abstract: Cardiac disorders are observed when excessive plasma concentrations of local anaesthetics are reached, following for instance intravascular accidental injection for epidural anaesthesia or brachial plexus block. Bupivacaine particularly, which is one of the most used local anaesthetics, adversely affects intraventricular conduction and cardiac contractile strength from the 3.0-4.0 micrograms/ml blood levels. Depression of conduction is especially to be feared, for it can result in reentrant arrhythmias likely to degenerate into often fatal ventricular fibrillation. Such accidents may sometimes occur at far lower concentrations, subsequent to diffusion into systemic circulation from the injection site (0.4-1.2 micrograms/ml). These accidents were probably due to various factors which concomitantly intervene during the anaesthesia. We could identify a number of these factors by associating them to an intravenous infusion of bupivacaine (0.04 mg/kg/min after a loading dose of 1.00 mg/kg) in animals (dogs and pigs) under electrocardiographic monitoring, in which conduction time, monophasic action potential duration, effective refractory period and electrical fibrillation threshold were determined in the ventricular fibres. The electrophysiological changes due to bupivacaine may be enhanced by 1) dilution hyponatremia (115-110 mmol/l) induced by a short (5 min) intravenous 10 ml/kg/min infusion of hypotonic solution and/or hyperkalemia (7-8 mmol/l) induced by 0.05 mmol/kg/min infusion of potassium chloride; 2) the acceleration of cardiac contractions (180-210 beats/min) induced by ventricular pacing; 3) mild hypothermia (35-34 degrees C) induced by blood cooling in an extracorporeal circuit; 4) myocardial ischaemia induced by complete temporary occlusion of the left anterior descending coronary artery near its origin. The risk of cardiac accidents, possibly severe, is therefore enhanced by each of these factors capable of lowering the concentration required for their triggering and, of course, the combination of two or several of them. On the contrary, the knowledge of these factors should allow to prevent most of cardiac accidents of locoregional anaesthesia.
authors.affiliation: Pharmacologie Médicale, Université Claude Bernard, Lyon.
authors.forename: Q
authors.initials: Q
authors.lastname: Timour
authors.forename: P
authors.initials: P
authors.lastname: Gaillard
authors.forename: B
authors.initials: B
authors.lastname: Bui-Xuan
authors.forename: T
authors.initials: T
authors.lastname: Vial
authors.forename: J C
authors.initials: JC
authors.lastname: Evreux
authors.forename: M
authors.initials: M
authors.lastname: Freysz
mesh_terms: D000059:Accidents; D000779:Anesthetics, Local / Q000009:adverse effects*; D000818:Animals; D002045:Bupivacaine / Q000009:adverse effects*; D009202:Cardiomyopathies / Q000139:chemically induced*; D004285:Dogs; D012307:Risk Factors; D013552:Swine
chemical_list: D000779:Anesthetics, Local; D002045:Bupivacaine
vernacular_title: Accidents cardiaques de l'anesthésie locorégionale: étude expérimentale des facteurs de risque avec la bupivacaïne.