title: Structure and mRNA expression of a bovine trp homologue related to mammalian trp2 transcripts.
abstract: Mammalian homologues of the transient receptor potential (trp) gene product from Drosophila melanogaster function as Ca2+-selective or non-selective cation channels. Complementary DNA was isolated from a bovine testis cDNA library which encodes bovine trp2 (btrp2), a protein of 432 amino acid residues comprising four predicted transmembrane segments. Btrp2 mRNA is expressed in bovine testis, spleen and liver but not in brain, heart, adrenal gland or retina. In bovine testis expression of btrp2 mRNA is restricted to spermatocytes but is not present in spermatogonia, Leydig or Sertoli cells suggesting that btrp2 may contribute to the formation of ion channels in sperm cells.
authors.affiliation: Institut für Pharmakologie und Toxikologie der Universität des Saarlandes, Homburg/Saar, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Wissenbach
authors.forename: G
authors.initials: G
authors.lastname: Schroth
authors.forename: S
authors.initials: S
authors.lastname: Philipp
authors.forename: V
authors.initials: V
authors.lastname: Flockerzi
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015220:Calcium Channels / Q000737:chemistry; D002417:Cattle; D029721:Drosophila Proteins; D006801:Humans; D019476:Insect Proteins / Q000737:chemistry; D008297:Male; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D010802:Phylogeny; D012333:RNA, Messenger / Q000378:metabolism*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D050052:TRPC Cation Channels; D013737:Testis / Q000166:cytology; D014018:Tissue Distribution; D050051:Transient Receptor Potential Channels
chemical_list: D015220:Calcium Channels; D029721:Drosophila Proteins; D019476:Insect Proteins; D008565:Membrane Proteins; D012333:RNA, Messenger; D050052:TRPC Cation Channels; C491859:TRPC2 protein, human; D050051:Transient Receptor Potential Channels; C113139:Trp2 protein, vertebrate; C063169:trp protein, Drosophila