title: Alphitol, a phenolic substance from Alphitonia zizyphoides which inhibits prostaglandin biosynthesis in vitro.
abstract: The new phenolic compound, 3,5-dihydroxy-4-methoxy phenethyl alcohol, named alphitol, and betulinic acid were from the bark of Alphitonia zizyphoides. The chemical structure of alphitol was determined by mass spectrometry in combination with one and two dimensional NMR, including HMBC. Both compounds inhibited prostaglandin biosynthesis in vitro, alphitol with an IC50 value of 0.66mM, which is of the same magnitude as acetyl salicylic acid.
authors.affiliation: Department of Pharmacy, Uppsala University, Sweden.
authors.forename: C
authors.initials: C
authors.lastname: Dunstan
authors.forename: B
authors.initials: B
authors.lastname: Liu
authors.forename: C J
authors.initials: CJ
authors.lastname: Welch
authors.forename: P
authors.initials: P
authors.lastname: Perera
authors.forename: L
authors.initials: L
authors.lastname: Bohlin
mesh_terms: D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry / Q000379:methods; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D011448:Prostaglandin Antagonists / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D010636:Phenols; D011448:Prostaglandin Antagonists; C113440:alphitol; D010626:Phenylethyl Alcohol