title: [Genetic structure of the population of Guarico, Venezuela, studied through isonymy].
abstract: The genetic structure of the State of Guárico, Venezuela, was studied through the distribution of surnames from individuals above 40 years of age, obtained from the register of electors. The sample studied consisted in 109,200 individuals and 14,138 different surnames. For each of the 32 counties of the State, the following estimators were calculated: percentage of the population included in surnames which appear only once (estimator A), percentage of the population included in the seven most frequent surnames (estimator B), the coefficient of consanguinity due to random isonymy (n phi ii), and Karlin and McGregors ni nu, an estimator of migration. The correlation between n phi ii and B was 0.97, indicating that 94% of the variation observed in the coefficient of consanguinity due to random isonymy is due to the seven most frequent surnames. The correlation between A and ni was 0.93, so that 86% of the variation observed in ni, is due to surnames which appear only once. On the other hand, correlations between A and B, and between n phi ii and nu were non significant (0.25 and 0.01 respectively), meaning that they are measuring different features of population structure: B and n phi ii, and v were non significant (0.25 and 0.01 respectively), meaning that they are measuring different features of population structure: B and n phi ii, isolation, and A and nu, migration. The most isolated counties of Guárico, according to n phi ii and B, are Santa Rita, Espino, El Calvario, Ortiz and Santa María de Ipire. Microdifferentiation of the State was studied through the estimation of RST, which gave a value of 0.0008. Comparing this value with those obtained in other Venezuelan States, it is found that Guárico, with Aragua and Yaracuy, are among the least differentiated States, probably because of the absence of important geographical barriers and the nearness to the Capital City of our country.
authors.affiliation: Laboratorio de Genética Humana, IVIC, Caracas, Venezuela. arodrigu@ivic.ivic.ve
authors.forename: A
authors.initials: A
authors.lastname: Rodríguez Larralde
authors.forename: I
authors.initials: I
authors.lastname: Barrai
mesh_terms: D000328:Adult; D005260:Female; D005828:Genetics, Population; D006801:Humans; D008297:Male; D009275:Names; D014687:Venezuela
vernacular_title: Estructura genética poblacional del Estado Guárico, Venezuela, estimada a través de isonimia.