Compartment boundaries: where, why and how?
In the 1960's, Garcia Bellido and colleagues uncovered the existence of developmental compartments in Drosophila. This observation has had a lasting impact on our understanding of developmental mechanisms in flies and vertebrates. Here, I review the work that demonstrated the existence of compartments. I then conjecture on why compartments exist and review the roles of various gene products in the maintenance of compartment boundaries.
Vincent
J P
JP
National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom. JP.Vincent@nimr.ac.uk
D000818:Animals; D019521:Body Patterning / Q000235:genetics / Q000502:physiology*; D002999:Clone Cells; D004330:Drosophila / Q000254:growth & development*; D029721:Drosophila Proteins; D018398:Homeodomain Proteins / Q000235:genetics / Q000502:physiology*; D019476:Insect Proteins / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000502:physiology
D029721:Drosophila Proteins; C063459:En protein, Drosophila; D018398:Homeodomain Proteins; D019476:Insect Proteins; D014157:Transcription Factors; D016212:Transforming Growth Factor beta; C064196:dpp protein, Drosophila; C106185:engrailed homeobox proteins