Distant metastasis of gastric cancer is associated with elevated expression of the antimetastatic nm23 gene.
To understand the clinical significance of nm23 gene expression in gastric cancer patients, the Nm23-H1 protein level of fresh resected specimens from a total of 37 gastric cancer patients was measured by Western blot analysis. The elevated nm23 expression group (Nm23-H1 protein level in tumor tissue greater than the 75th percentile value of patients) was significantly associated with the histologically differentiated type (P = 0.036). This group had a higher incidence of distant (hematogeneous) metastasis (P = 0.0023) and a lower 2-year disease-free survival rate (P = 0.033) than the non-elevated group. The result was not consistent with the previous assumption that nm23 is an antimetastatic gene for gastric cancer.
Wang
C S
CS
Department of Surgery, Chang Gung Medical College, Taipei, Taiwan.
Lin
K H
KH
Hsu
Y C
YC
Hsueh
S
S
D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000328:Adult; D000368:Aged; D018279:Carcinoma, Signet Ring Cell / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D020559:Monomeric GTP-Binding Proteins; D054778:NM23 Nucleoside Diphosphate Kinases; D009362:Neoplasm Metastasis; D009701:Nucleoside-Diphosphate Kinase; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology; D014157:Transcription Factors / Q000235:genetics*
D054778:NM23 Nucleoside Diphosphate Kinases; D014157:Transcription Factors; C517938:NME1 protein, human; D009701:Nucleoside-Diphosphate Kinase; D020559:Monomeric GTP-Binding Proteins