Chemokines, lymphocytes and viruses: what goes around, comes around.
Chemokines are believed to be the long-sought soluble mediators of selective lymphocyte recruitment. As most selectin-integrin interactions are nonselective, it is thought that the discrimination seen during lymphocyte infiltration into tissues is brought about by the actions of distinct chemokines. Developments over the past year have demonstrated the expanding roles of these factors in lymphocyte chemoattraction, normal trafficking, and viral immunity.
Nelson
P J
PJ
Department of Internal Medicine, Clinic Innenstadt, Ludwig-Maximilians-University of Munich, Germany. Nelson@medpoli.med.uni-muenchen.de
Krensky
A M
AM
D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D015815:Cell Adhesion Molecules / Q000502:physiology; D018925:Chemokines / Q000037:antagonists & inhibitors / Q000502:physiology*; D002634:Chemotaxis, Leukocyte / Q000502:physiology*; D015658:HIV Infections / Q000276:immunology / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D016023:Integrins / Q000502:physiology; D016131:Lymphocyte Subsets / Q000166:cytology / Q000276:immunology*; D018448:Models, Immunological; D011212:Poxviridae / Q000502:physiology; D011213:Poxviridae Infections / Q000276:immunology / Q000473:pathology; D019707:Receptors, Chemokine / Q000187:drug effects / Q000502:physiology; D018418:Th2 Cells / Q000166:cytology / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology* / Q000473:pathology
D015815:Cell Adhesion Molecules; D018925:Chemokines; D016023:Integrins; D019707:Receptors, Chemokine