Hypothesis: are fatty acid patterns characteristic of essential fatty acid deficiency indicative of oxidative stress?
Several unrelated diseases show plasma and tissue fatty acid patterns characteristic of those seen in Essential Fatty Acid Deficiency Disease (EFADD). A common feature occurring in all these diseases is oxidative stress. We hypothesize that reactive oxygen species or products of oxidative damage, particularly those derived from lipids, act as signal molecules to alter desaturase enzymes and induce the fatty acid patterns characteristic of EFADD.
Gutteridge
J M
JM
Oxygen Chemistry Laboratory, Royal Brompton Hospital, London.
Quinlan
G J
GJ
Yamamoto
Y
Y
D000818:Animals; D004041:Dietary Fats / Q000378:metabolism; D044943:Fatty Acid Desaturases / Q000378:metabolism*; D005227:Fatty Acids / Q000097:blood*; D005228:Fatty Acids, Essential / Q000172:deficiency*; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation; D008171:Lung Diseases / Q000097:blood; D008322:Mammals / Q000378:metabolism; D008954:Models, Biological; D018384:Oxidative Stress; D017382:Reactive Oxygen Species; D013230:Stearoyl-CoA Desaturase; D013577:Syndrome
D004041:Dietary Fats; D005227:Fatty Acids; D005228:Fatty Acids, Essential; D005231:Fatty Acids, Unsaturated; D017382:Reactive Oxygen Species; D044943:Fatty Acid Desaturases; D013230:Stearoyl-CoA Desaturase; C029627:delta-9 fatty acid desaturase