Premature ejaculation and serotonergic antidepressants-induced delayed ejaculation: the involvement of the serotonergic system.
Premature ejaculation has generally been considered a psychosexual disorder with psychogenic aetiology. Although still mainly treated by behavioural therapy, in recent years double-blind studies have indicated the beneficial effects of some of the serotonergic antidepressants (SSRIs) in delaying ejaculation. We describe here the neurophysiology and the peripheral neuroanatomy of ejaculation and provide a review of the involvement of serotonin in the central nervous system in relation to serotonergic nuclei and their projections. A hypothesis of the role of 5-HT1A and 5-HT2C receptors in premature ejaculation is postulated.
Waldinger
M D
MD
Department of Psychiatry and Neurosexology, Leyenburg Hospital, The Hague, The Netherlands.
Berendsen
H H
HH
Blok
B F
BF
Olivier
B
B
Holstege
G
G
D000818:Animals; D004542:Ejaculation / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008297:Male; D012701:Serotonin / Q000502:physiology*; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*
D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors