[Soluble IL-6 receptors].
Both subunits of IL-6 membrane--associated receptor, IL-6R and gp130 can exhibit in a soluble forms--sIL-6R and sgp130 respectively. Soluble IL-6 receptor (sIL-6R) can bind IL-6 and mediate IL-6 function through association with gp130 which is the signal transducing protein. In contrast to other receptors, sIL-6R has a potential to enhance the IL-6 biological function. sIL-6R and sgp130 were found in appreciable amounts in body fluids, although the exact cellular source and function of these proteins are not completely clear.
Jabłońska
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Zakład Immunopatologii Akademii Medycznej w Białymstoku.
D000818:Animals; D015703:Antigens, CD / Q000378:metabolism*; D001826:Body Fluids / Q000378:metabolism; D050822:Cytokine Receptor gp130; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism*; D019947:Receptors, Interleukin-6 / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D015854:Up-Regulation
D015703:Antigens, CD; C494199:IL6ST protein, human; D008562:Membrane Glycoproteins; D019947:Receptors, Interleukin-6; D050822:Cytokine Receptor gp130
Rozpuszczalne receptory IL-6.