title: Poor prognosis in early gastric cancer complicated by five or more positive nodes.
abstract: OBJECTIVE
  Despite the increased frequency of early gastric cancer, little is known about the clinicopathological features of early gastric cancers complicated by lymph node metastasis. This study was designed to determine whether the number of involved lymph nodes is associated with prognosis in patients with early gastric cancer.
  
  
  METHODS
  Fifty one patients with node-positive early gastric cancer were reviewed retrospectively from hospital records. The patients were divided into two groups according to the number of positive nodes: a) 40 patients with 1-4 positive nodes, b) 11 patients with 5 or more positive nodes.
  
  
  RESULTS
  The patients with 5 or more positive nodes showed poorer prognosis than patients with less than 5 positive nodes.
  
  
  CONCLUSIONS
  Early gastric cancer patients with 5 or more positive nodes show a poorer prognosis than early gastric cancer patients with less than 5 positive nodes. Since surgery alone cannot completely cure patients with early gastric cancer complicated by 5 or more positive nodes, intensive postoperative chemo-immunotherapy should be administered to these patients.
authors.affiliation: First Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kitamura
authors.forename: S
authors.initials: S
authors.lastname: Nishida
authors.forename: K
authors.initials: K
authors.lastname: Yamamoto
authors.forename: D
authors.initials: D
authors.lastname: Ichikawa
authors.forename: K
authors.initials: K
authors.lastname: Okamoto
authors.forename: T
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: K
authors.initials: K
authors.lastname: Sawai
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
mesh_terms: D016022:Case-Control Studies; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D015996:Survival Rate