title: shaven and sparkling are mutations in separate enhancers of the Drosophila Pax2 homolog.
abstract: We have previously shown that the sparkling gene, which like mammalian Pax2 plays an important role in eye development, is encoded by the Drosophila homolog of Pax2. Here we demonstrate that D-Pax2 also encodes the shaven function, which is crucial during bristle development. Both sv and spa alleles, previously thought to represent different genes, are mutations in two widely separated enhancers of D-Pax2. The sv function of D-Pax2 acts in at least two distinct steps of mechanosensory bristle development: the specification of the alternative fate of shaft as opposed to socket cell, and later the differentiation of the shaft cell.
authors.affiliation: Institute for Molecular Biology, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.
authors.forename: W
authors.initials: W
authors.lastname: Fu
authors.forename: H
authors.initials: H
authors.lastname: Duan
authors.forename: E
authors.initials: E
authors.lastname: Frei
authors.forename: M
authors.initials: M
authors.lastname: Noll
mesh_terms: D000483:Alleles; D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics*; D004330:Drosophila / Q000235:genetics*; D029721:Drosophila Proteins; D004742:Enhancer Elements, Genetic; D005123:Eye / Q000196:embryology; D005136:Eye Proteins / Q000235:genetics*; D017344:Genes, Insect; D005804:Genes, Lethal; D005816:Genetic Complementation Test; D019476:Insect Proteins / Q000235:genetics; D007814:Larva; D016254:Mutagenesis, Insertional; D009154:Mutation; D051762:PAX2 Transcription Factor; D018626:Retroelements; D012679:Sense Organs / Q000196:embryology; D017385:Sequence Homology; D014157:Transcription Factors / Q000235:genetics*; D019076:Transgenes
chemical_list: D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D005136:Eye Proteins; D019476:Insect Proteins; D051762:PAX2 Transcription Factor; D018626:Retroelements; D014157:Transcription Factors; C107990:sv protein, Drosophila