Renal function in primary liver transplant recipients receiving neoral (cyclosporine) versus prograf (tacrolimus).
Immunosuppressive efficacy of Neoral and Prograf following primary hepatic transplantation was comparable. Incidence of rejection episodes, infectious complications, hypertension, and postoperative diabetes mellitus was comparable. Although clinical use of both immunosuppressants was associated with early compromise in renal function, no progressive renal dysfunction was observed.
Van Buren
D
D
Divison of Renal Transplantation, Vanderbilt University Medical Center, Nashville, TN 37212, USA.
Payne
J
J
Geevarghese
S
S
MacDonell
R
R
Chapman
W
W
Wright
J K
JK
Helderman
J H
JH
Richie
R
R
Pinson
C W
CW
D000704:Analysis of Variance; D001379:Azathioprine / Q000627:therapeutic use; D003404:Creatinine / Q000097:blood; D016572:Cyclosporine / Q000009:adverse effects / Q000627:therapeutic use*; D003920:Diabetes Mellitus / Q000453:epidemiology; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000453:epidemiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D015994:Incidence; D007668:Kidney / Q000187:drug effects*; D016031:Liver Transplantation / Q000276:immunology* / Q000401:mortality / Q000502:physiology; D011183:Postoperative Complications / Q000453:epidemiology; D011241:Prednisone / Q000627:therapeutic use; D011446:Prospective Studies; D012044:Regression Analysis; D015996:Survival Rate; D016559:Tacrolimus / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D003404:Creatinine; D001379:Azathioprine; D011241:Prednisone; D016559:Tacrolimus