The place of migraine as a channelopathy.
Over the past 8 years an increasing awareness of the role of mutant ion channels in episodic diseases of humans has emerged. The importance of these discoveries is now being extended to a growing list of membrane excitability disorders of the nervous system. Molecular characterization of episodic diseases that are rare and monogenic will ultimately shed light on more common and complex disorders, such as epilepsy and migraine.
Ptácek
L J
LJ
Department of Neurology, Howard Hughes Medical Institute, University of Utah, Salt Lake City 84112, USA.
D018118:Chloride Channels / Q000502:physiology; D004827:Epilepsy / Q000235:genetics; D006801:Humans; D007473:Ion Channels / Q000502:physiology*; D008881:Migraine Disorders / Q000235:genetics / Q000503:physiopathology*; D009222:Myotonia / Q000503:physiopathology; D010245:Paralyses, Familial Periodic / Q000503:physiopathology; D010507:Periodicity; D015222:Sodium Channels / Q000502:physiology
D018118:Chloride Channels; D007473:Ion Channels; D015222:Sodium Channels