Bioinorganic chemistry and drug design: here comes zinc again.
The structures and reactions of metal ions in proteins are of tremendous interest in bioinorganic chemistry, as is the potential for metals in creating novel medicines. New results combine these aspects in describing an unexpected mode for metal-mediated drug efficacy that relies on well-established principles of metalloprotein structure.
Thorp
H H
HH
Department of Chemistry, University of North Carolina, Chapel Hill 27599-3290, USA.
D000818:Animals; D015195:Drug Design; D006801:Humans; D008667:Metalloproteins / Q000737:chemistry; D008958:Models, Molecular; D015032:Zinc / Q000737:chemistry*
D008667:Metalloproteins; D015032:Zinc