[Effect of human recombinant gamma-interferon on proliferative activity of human laryngeal cancer cell lines].
The effect of human on PCNA expressions of HEP-2 lines was investigated using LSAB (Labelled streptacidin biotin method) with monoclonal antibody Ki-67 (anti-PCNA). The results showed that the PCNA expression which reflects the proliferative activity of cells was dependent on dose of rhu-IFN-gamma in HEP-2 cell lines. Thus, our data suggest that rhu-IFN-gamma might be useful in the treatment of laryngeal cancer because it provides effective cytostatic.
Ruan
Q
Q
Department of Otolaryngology, Tongji Hospital, Tongji Medical University, Wuhan.
Liu
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Q
Tan
S
S
D004305:Dose-Response Relationship, Drug; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology*; D007822:Laryngeal Neoplasms / Q000378:metabolism / Q000473:pathology*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism*; D011994:Recombinant Proteins; D014407:Tumor Cells, Cultured
D018809:Proliferating Cell Nuclear Antigen; D011994:Recombinant Proteins; D007371:Interferon-gamma