title: Lack of relationship between the P1A1/P1A2 polymorphism of platelet glycoprotein IIIa and premature myocardial infarction.
abstract: BACKGROUND
  The P1A1/P1A2 polymorphism of the platelet glycoprotein IIIa has been variably associated with an increased risk of coronary thrombosis.
  
  
  METHODS
  We investigated the linkage between the P1A1/P1A2 polymorphism and the risk of myocardial infarction in 98 patients who suffered their first myocardial infarction at the age of 45 years or less and 98 well-matched control subjects without coronary artery disease. Lipid parameters were measured using conventional methods of clinical chemistry; P1A genotypes were determined by polymerase chain reaction and restriction enzyme digestion.
  
  
  RESULTS
  There was no significant difference in the prevalence of P1A2-positive genotypes (either P1A1/P1A2 or P1A2/P1A2) between patients and control subjects (chi 2 = 0.66, d.f. = 1, P = 0.41).
  
  
  CONCLUSIONS
  These results suggest that the P1A2 polymorphism of the platelet glycoprotein IIIa does not contribute to the genetic susceptibility to premature myocardial infarction.
authors.affiliation: Department of Internal Medicine, University of Turin, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Scaglione
authors.forename: S
authors.initials: S
authors.lastname: Bergerone
authors.forename: G
authors.initials: G
authors.lastname: Gaschino
authors.forename: M
authors.initials: M
authors.lastname: Imazio
authors.forename: A
authors.initials: A
authors.lastname: Maccagnani
authors.forename: R
authors.initials: R
authors.lastname: Gambino
authors.forename: M
authors.initials: M
authors.lastname: Cassader
authors.forename: M
authors.initials: M
authors.lastname: Di Leo
authors.forename: G
authors.initials: G
authors.lastname: Macchia
authors.forename: A
authors.initials: A
authors.lastname: Brusca
authors.forename: G
authors.initials: G
authors.lastname: Pagano
authors.forename: P
authors.initials: P
authors.lastname: Cavallo-Perin
mesh_terms: D000328:Adult; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000097:blood / Q000235:genetics*; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D019039:Platelet Glycoprotein GPIIb-IIIa Complex