The murine gap junction gene connexin36 is highly expressed in mouse retina and regulated during brain development.
A new gap junction gene isolated from rat brain cDNA, mouse retina cDNA and mouse genomic DNA is called connexin36, since it codes for a connexin protein of 321 amino acids corresponding to the theoretical molecular mass of 36045 kDa (rat) and 36084 kDa (mouse). Only one amino acid residue differs between rat and mouse connexin36. In the single murine connexin36 gene, an 1.14-kb intron interrupts the coding region, similar as in the homologous skate connexin35 gene. Because of this unique feature, mouse connexin36 differs from the other 13 murine connexin genes and is suggested to form a new delta subclass of connexins. Connexin36 mRNA (2.9 kb) is highly expressed in adult retina and less abundant in brain where it gradually increased during fetal development until day 7 post partum, and decreased thereafter.
Söhl
G
G
Institut für Genetik, Abteilung Molekulargenetik, Universität Bonn, Germany.
Degen
J
J
Teubner
B
B
Willecke
K
K
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000196:embryology* / Q000378:metabolism; D017630:Connexins / Q000235:genetics*; D018076:DNA, Complementary; D005136:Eye Proteins / Q000235:genetics*; D017629:Gap Junctions / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D051379:Mice; D008969:Molecular Sequence Data; D051381:Rats; D012160:Retina / Q000378:metabolism*; D000097004:Gap Junction delta-2 Protein
D017630:Connexins; D018076:DNA, Complementary; D005136:Eye Proteins; D000097004:Gap Junction delta-2 Protein