Cognitive screening examinations for silent cerebral infarcts in sickle cell disease.
OBJECTIVE
In children with sickle cell disease (SCD), silent cerebral infarcts are the most frequent cause of neurologic injury. We determined the sensitivity and specificity of selective neurocognitive measures when separating children with silent cerebral infarcts and SCD from sibling controls. Additionally, we tested the validity of the same cognitive measures to identify patients with overt strokes.


METHODS
We examined performance on a neuropsychologic battery containing measures of attention/executive, spatial, language, memory, and motor functioning for seven children with SCD and silent cerebral infarct, 21 children with SCD and overt stroke, and 17 normal siblings. Diagnosis of cerebral infarct was based on results of MRI.


RESULTS
Measures from the attention and executive domains were the most useful for identifying children with silent cerebral infarct. The Test of Variables of Attention was the most robust measure and yielded a sensitivity rate of 86% and a specificity rate of 81%. This measure also showed a sensitivity rate of 95% in identifying overt stroke.


CONCLUSIONS
Brief cognitive screening measures, if properly constructed, may be an effective means of identifying children with silent cerebral infarct. Future prospective studies should be pursued to assess the utility of cognitive screening for silent cerebral infarcts in SCD.
DeBaun
M R
MR
Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Schatz
J
J
Siegel
M J
MJ
Koby
M
M
Craft
S
S
Resar
L
L
Chu
J Y
JY
Launius
G
G
Dadash-Zadeh
M
M
Lee
R B
RB
Noetzel
M
M
D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications*; D001288:Attention / Q000502:physiology; D002544:Cerebral Infarction / Q000175:diagnosis* / Q000209:etiology* / Q000523:psychology; D002648:Child; D003071:Cognition / Q000502:physiology*; D006801:Humans; D009483:Neuropsychological Tests; D012680:Sensitivity and Specificity