title: Locus control regions, chromatin activation and transcription.
abstract: The past year has seen interesting advances in our understanding of the action of locus control regions. For the first time, the chromosomal distance was described in detail as a parameter in positive/negative regulation of transcription via gene competition. A number of publications have also described negative regulatory elements which restrict the action of locus control regions and other regulatory regions to specific genes and/or specific tissues. The emerging picture indicates that several very different types of negative regulation ensure that transcriptional activation occurs only in the appropriate cells.
authors.affiliation: Erasmus University, Faculty of Medicine, Department of Cell Biology and Genetics, Rotterdam, The Netherlands. fraser@ch1.fgg.eur.nl
authors.forename: P
authors.initials: P
authors.lastname: Fraser
authors.forename: F
authors.initials: F
authors.lastname: Grosveld
mesh_terms: D000818:Animals; D002843:Chromatin / Q000235:genetics*; D006801:Humans; D019901:Locus Control Region / Q000502:physiology*; D015533:Transcriptional Activation / Q000235:genetics*
chemical_list: D002843:Chromatin