[Acute posterior wall infarct after factor VIII concentrate administration to a patient with severe hemophilia A].
METHODS
A 69-year-old man with severe haemophilia A sustained an acute myocardial infarction (MI) after self-administration of 3000 units factor VIII over 10 min. On admission he had no signs of heart failure.


METHODS
The ECG showed an acute posterior wall MI. Creatinekinase rose to a maximum of 321 U/l with a significant MB proportion. The echocardiogram demonstrated hypokinesia of the posterior wall.


METHODS
After initial thrombolysis treatment with a total of 100 mg rtPA according to an accelerated scheme coronary angiography, performed because the symptoms persisted, revealed two-vessel disease. A subtotal stenosis of the right coronary artery was balloon-dilated with good primary results. Regular factor VIII substitution was temporarily administered with the aim of initially achieving high normal levels of factor VIII activity.


CONCLUSIONS
Factor VIII substitution in haemophilia A may promote thrombotic complications. Thrombolytic treatment and balloon angioplasty of acute MI can be successfully performed even in patients with severe haemophilia A.
Lickfett
L
L
Medizinische Universitätsklinik und Poliklinik, Bonn. Lickfett@uni-bonn.de
Hagendorff
A
A
Jung
W
W
Pizzulli
L
L
Brackmann
H H
HH
Lüderitz
B
B
D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D003131:Combined Modality Therapy; D017023:Coronary Angiography; D004452:Echocardiography; D004562:Electrocardiography; D005169:Factor VIII / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006467:Hemophilia A / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D012646:Self Administration; D015912:Thrombolytic Therapy
D005169:Factor VIII
Akuter Hinterwandinfarkt nach Faktor-VIII-Konzentrat bei schwerer Hämophilie A.