[Hydrocortisone Acetate Reference Standard (Control 961) of National Institute of Health Sciences].
The raw material of hydrocortisone acetate was tested for the preparation of the "Hydrocortisone Acetate Reference Standard (Control 961)". Analytical data obtained were as follows: IR spectrum, specific absorption wave numbers at 3428, 1748, 1723, 1631, and 1375 cm-1; specific absorbance, E1cm1% (242 nm) = 406; thin-layer chromatography, no impurities were detected until 0.05 microgram; high-performance liquid chromatography (HPLC), 2-3 impurities were detected and the amount of the total impurities was estimated to be about 0.2%; assay by HPLC, 100.7%. Based on the above results, the raw material was authorized as the Japanese Pharmacopoeia Reference Standard (Control 961).
Tagashira
Y
Y
Kitajima
A
A
Maekawa
K
K
Yoshii
K
K
Tanimoto
T
T
Okada
S
S
D006854:Hydrocortisone / Q000031:analogs & derivatives* / Q000592:standards; D007564:Japan; D012015:Reference Standards
C021650:hydrocortisone acetate; D006854:Hydrocortisone