Primary manifestation of Hodgkin's disease in the central nervous system.
A 62-year-old woman presented with loss of memory and a mild hemiparesis. Neuroradiology demonstrated a left frontoparietal tumour. Biopsy specimens of this lesion revealed intracerebral Hodgkin's lymphoma, a diagnosis supported by immunohistochemical reactions of the tumour cells for the CD30 antigen. Additional cell cycle studies revealed a high proliferative activity of the tumour cells in association with absence of apoptosis. There was no evidence that overexpression of bcl-2 or Epstein-Barr virus infection was involved in the pathogenesis of this neoplasm. Lymphomas in the lung were detected 3 months later. Following neurosurgical excision, radiotherapy, and chemotherapy, the patient had no evidence of Hodgkin's disease after 13 months of follow-up.
Deckert-Schlüter
M
M
Institut für Neuropathologie, Universitätskliniken Bonn, Germany.
Marek
J
J
Setlík
M
M
Marková
J
J
Pakos
E
E
Fischer
R
R
Wiestler
O D
OD
D017209:Apoptosis; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D003937:Diagnosis, Differential; D005260:Female; D006689:Hodgkin Disease / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D017730:Ki-1 Antigen / Q000378:metabolism; D016393:Lymphoma, B-Cell / Q000378:metabolism / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008479:Mediastinal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D011859:Radiography; D016539:Reed-Sternberg Cells / Q000473:pathology
D017730:Ki-1 Antigen; D019253:Proto-Oncogene Proteins c-bcl-2