title: Progress in the development of Helicobacter pylori strain typing methods.
abstract: Helicobacter pylori is very different from other Gram negative bacteria that inhabit the human gastroduodenal tract. Its success in adapting to colonise and persist in the stomach is reflected in key features such as unique chemical structure and architecture of lipopolysaccharide, sheathed flagella, genomic diversity, and potent urease activity. Strain diversity within the species is well established and so the challenge is to exploit variations in these features for developing relevant epidemiological typing methods.
authors.affiliation: Helicobacter Reference Unit, PHLS Laboratory of Enteric Pathogens, PHLS Central Public Health Laboratory, London.
authors.forename: R J
authors.initials: RJ
authors.lastname: Owen
authors.forename: J
authors.initials: J
authors.lastname: Gibson
authors.forename: E
authors.initials: E
authors.lastname: Slater
mesh_terms: D004269:DNA, Bacterial / Q000032:analysis*; D004739:England; D005838:Genotype; D016480:Helicobacter pylori / Q000145:classification* / Q000235:genetics; D006801:Humans; D016133:Polymerase Chain Reaction; D012680:Sensitivity and Specificity; D012703:Serotyping / Q000379:methods*; D013045:Species Specificity
chemical_list: D004269:DNA, Bacterial