title: Neoadjuvant chemotherapy for hypervascular malignant brain tumors of childhood.
abstract: Some large hypervascular brain tumors pose an exceptional challenge to surgical resection, particularly in young children with small blood volumes. To limit blood loss during resection of hypervascular tumors, the authors used upfront chemotherapy as the primary treatment modality in 2 young children. This produced a dramatic reduction in tumor size and vascularity and greatly facilitated definitive surgical removal.
authors.affiliation: Division of Pediatric Neurosurgery, Rainbow Babies and Children's Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA.
authors.forename: A A
authors.initials: AA
authors.lastname: Razzaq
authors.forename: A R
authors.initials: AR
authors.lastname: Cohen
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000098:blood supply / Q000188:drug therapy* / Q000601:surgery; D002277:Carcinoma / Q000098:blood supply / Q000188:drug therapy* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D002675:Child, Preschool; D016545:Choroid Plexus Neoplasms / Q000098:blood supply / Q000188:drug therapy* / Q000601:surgery; D003131:Combined Modality Therapy; D003952:Diagnostic Imaging; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D018365:Neoplasm, Residual / Q000098:blood supply / Q000188:drug therapy / Q000601:surgery; D009389:Neovascularization, Pathologic / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D018242:Neuroectodermal Tumors, Primitive / Q000098:blood supply / Q000188:drug therapy* / Q000601:surgery; D012086:Reoperation