title: T-cell acute lymphoblastic leukemia occurring in a patient with acute promyelocytic leukemia.
abstract: Secondary acute lymphoblastic leukemia (sALL) following acute myeloid leukemia (AML) is a rare event; only eight cases have been reported. We report a patient with acute promyelocytic leukemia (APL), in hematological and molecular remission who developed T-ALL three years after the diagnosis of APL. The morphological, cytochemical, phenotypical and molecular features of this T-ALL were different from those of the previous APL. The absence of t(15;17), negative PML/RAR alpha at reverse transcription polymerase chain reaction (RT-PCR) analysis and presence of TcR delta support the hypothesis that the T-ALL in this sALL case originated from a different clone from that of the APL cells.
authors.affiliation: Divisione di Ematologia, Università di Bari, Italy. ematba@cimedoc.uniba.it
authors.forename: V
authors.initials: V
authors.lastname: Liso
authors.forename: G
authors.initials: G
authors.lastname: Specchia
authors.forename: A
authors.initials: A
authors.lastname: Pannunzio
authors.forename: A
authors.initials: A
authors.lastname: Mestice
authors.forename: G
authors.initials: G
authors.lastname: Palumbo
authors.forename: A
authors.initials: A
authors.lastname: Biondi
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000473:pathology*; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000473:pathology*