[Antibodies against prolactin in patients with systemic lupus erythematosus and hyperprolactinemia].
We investigated patients with lupus erythematosus to detect the presence of hyperprolactinemia and to determine it's origin. From the seric specimens obtained in 225 patients with LES, we found 37 (14.5%) with hyperprolactinemia and they were trated with polyethylenglicol, in 11 of 37 patients (29.7%) had a high significance of prolactin precipitation (PRL). The test in gel filtration shown the big-big PRL (Molecular weight > 100 kDa) was the predominant form from PRL seric in these patients and no woman had clinic effects of hyperprolactinemia as galactorrhea and/or amenorrhea. The big-big PRL essence was due to an antibody, with it was found like a immune complex (Ig-PRL). This evidence suggest the patients with LES and hyperprolactinemia have a very high incidence of macroprolactinemia relationated to antibodies anti-PRL, and in spite of the hyperprolactinemia not have clinical effects like amenorrhea and/or galactorrhea, and it is other cause to explain the high incidence of hyperprolactinemia in patients with LES.
Leaños Miranda
L
L
Unidad de Investigación Médica en Imnunología, Hospital de Pediatría, CMN Siglo XXI, IMSS, México, D.F., México.
Bustos López
H H
HH
Fraga Mouret
A
A
Blanco Favela
F
F
Dalila Pascoe Lira
M E
ME
Dalila Pascoe Lira
C
C
D001323:Autoantibodies; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008297:Male; D011388:Prolactin / Q000276:immunology*
D001323:Autoantibodies; D011388:Prolactin
Autoanticuerpos dirigidos contra prolactina en pacientes con lupus eritematoso sistémico e hiperprolactinemia.