title: The effect of forskolin on the sound-evoked potentials in the guinea pig cochlea.
abstract: The effect of forskolin (FSK) on cochlear sound-evoked potentials was examined in the guinea pig. The perfusion of the scala vestibuli (SV) with FSK (2 x 10(-4) M) produced a significant increase in the amplitude of negative summating potential (- SP) with no change in cochlear microphonics (CM) amplitude, and a significant decrease in the amplitude of compound action potential (CAP) with a significant prolongation of N1 latency and a 20 dB CAP threshold elevation. The results lead us to speculate that FSK-induced changes may be involved in the transient formation of endolymphatic hydrops.
authors.affiliation: Department of Otolaryngology, Nara Medical University, Kashihara City, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Kitano
authors.forename: N
authors.initials: N
authors.lastname: Mori
authors.forename: K
authors.initials: K
authors.lastname: Nario
authors.forename: K
authors.initials: K
authors.lastname: Doi
authors.forename: T
authors.initials: T
authors.lastname: Matsunaga
mesh_terms: D000818:Animals; D003051:Cochlea / Q000187:drug effects* / Q000502:physiology; D003055:Cochlear Microphonic Potentials / Q000187:drug effects* / Q000502:physiology; D005576:Colforsin / Q000494:pharmacology*; D018159:Endolymphatic Hydrops / Q000209:etiology; D006168:Guinea Pigs; D017136:Ion Transport
chemical_list: D005576:Colforsin