Mathematical model for the blood coagulation prothrombin time test.
A mathematical model for the prothrombin time test is proposed. The time course of clotting factor activation during coagulation was calculated, and the sensitivity of the test to a decrease in the concentrations of coagulation proteins or their activities was studied. The model predicts that only severe coagulation disorders connected with a more than five-fold decrease in the concentrations or activities of the blood coagulation factors can be revealed by the test.
Khanin
M A
MA
Laboratory of Theoretical Biology, Russian State University of Technology, Moscow. khanin@landau.ac.ru
Rakov
D V
DV
Kogan
A E
AE
D001779:Blood Coagulation Factors / Q000032:analysis; D001780:Blood Coagulation Tests; D006801:Humans; D008954:Models, Biological; D010314:Partial Thromboplastin Time; D012680:Sensitivity and Specificity
D001779:Blood Coagulation Factors