End-stage renal failure due to crescentic glomerulonephritis in a patient with Behçet's syndrome. Review of the literature.
We report a rare case of a patient with Behçet's syndrome who developed end-stage renal failure due to crescentic glomerulonephritis (GN). A 20-year-old male patient had suffered from uveitis, aphthous mouth ulcers and genital ulceration for the past 7 years. His renal function rapidly deteriorated and renal biopsy specimens obtained when his serum creatinine level was 3 mg/dl showed diffuse proliferative GN with fibrous crescent formation in 75% of glomeruli excluding totally sclerotic glomeruli. Immune complexes were identified by demonstration of complement and immunoglobulins in the glomeruli. He developed end-stage renal failure during a 1-year course and received maintenance hemodialysis. We reviewed the literature on severe forms of GN in patients with Behçet's syndrome.
Sakemi
T
T
Department of Internal Medicine, Saga Medical School, Japan.
Yoshiyuki
T
T
Ikeda
Y
Y
Suzuki
N
N
Nagasawa
K
K
D000328:Adult; D001528:Behcet Syndrome / Q000150:complications*; D001706:Biopsy; D005921:Glomerulonephritis / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology*; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male