Flavonoids reduce morphine withdrawal in-vitro.
The effects of quercetin, flavone, catechin and chrysin on the naloxone-precipitated withdrawal contracture of the acute morphine-dependent guinea-pig ileum have been investigated in-vitro. After 4 min in-vitro exposure to morphine a strong contracture of guinea-pig isolated ileum was observed after the addition of naloxone. All the flavonoids, injected 10 min before morphine at concentrations between 10(-7) and 10(-5) M, were capable of blocking naloxone-induced contracture after exposure to morphine in a concentration-dependent fashion. IC50 values calculated for quercetin, flavone, catechin and chrysin were 2.7 x 10(-6), 7.3 x 10(-7), 8.5 x 10(-7) and 5.3 x 10(-6) M, respectively. These results suggest that flavonoids might play an important role in the control of morphine withdrawal.
Capasso
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Department of Pharmaceutical Sciences, University of Salerno, Penta di Fisciano, Italy.
Piacente
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Pizza
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Sorrentino
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D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002392:Catechin / Q000627:therapeutic use; D004347:Drug Interactions; D004558:Electric Stimulation; D005419:Flavonoids / Q000627:therapeutic use*; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D008297:Male; D009020:Morphine / Q000009:adverse effects*; D009119:Muscle Contraction / Q000187:drug effects*; D009270:Naloxone / Q000627:therapeutic use; D009292:Narcotic Antagonists / Q000627:therapeutic use; D011794:Quercetin / Q000627:therapeutic use; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*
D005419:Flavonoids; D009292:Narcotic Antagonists; D009270:Naloxone; D009020:Morphine; D002392:Catechin; D011794:Quercetin; D000109:Acetylcholine