Cloning and analysis of a transcript derived from two contiguous genes of the cathelicidin family.
Bac4 is a bovine cathelicidin gene contiguous to another member of this family named Bac7. Although mutations in the sequence suggested that Bac4 gene might be non-functional, primers based on Bac4 specific sequences allowed amplification of a 900 bp cDNA. The transcript comprises the sequences of exons 1, 2 and 3 of Bac7, and of exons 2, 3 and 4 of Bac4 gene and may result from a weak termination control of the transcription of the upstream Bac7 gene.
Scocchi
M
M
Laboratorio Nazionale Consorzio Interuniversitario Biotecnologie, Area Science Park, Padriciano, 99, I-34012 Trieste, Italy.
Wang
S
S
Gennaro
R
R
Zanetti
M
M
D000595:Amino Acid Sequence; D000818:Animals; D023181:Antimicrobial Cationic Peptides; D001483:Base Sequence; D001798:Blood Proteins / Q000235:genetics*; D054804:Cathelicidins; D002417:Cattle; D003001:Cloning, Molecular; D018076:DNA, Complementary; D008969:Molecular Sequence Data; D017423:Sequence Analysis, RNA; D017386:Sequence Homology, Amino Acid
D023181:Antimicrobial Cationic Peptides; D001798:Blood Proteins; D054804:Cathelicidins; D018076:DNA, Complementary; C053368:cationic antimicrobial protein 57, human