[Brain monoamine oxidases in rats selected for their predisposition to pendular-like movements of the head and shoulder girdle].
Brain MAO activity was studied in male rats from the strains bred from Wistar stock for predisposition to pendulum movements (PM+) and for the absence of such predisposition (PM-). By 16.00 o'clock, in PM+ rats MAO A activity significantly increased in the brain hemispheres and decreased in the brainstem. By this time, MAO B/MAO A ratio decreased in the hemispheres and increased in the brainstem. Emotional (immobilization) stress induced an increase in activity both of MAO A and MAO B in the brainstem of PM+ rats and increase only in MAO A activity in the hemispheres of PM- rats. Actinomycin D abolished the effect of stress on MAO A and MAO B in PM+ rats but increased MAO A activity in the hemispheres of PM- rats. Possible molecular modifications are discussed in regulation of MAO activity in PM+ rats.
Voĭtenko
N N
NN
Institute of Cytology and Genetics, Russian Academy of Sciences, Siberian Branch, Novosibirsk.
Barykina
N N
NN
Kolpakov
V G
VG
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology; D003609:Dactinomycin / Q000494:pharmacology; D004198:Disease Susceptibility; D019416:Head Movements / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008995:Monoamine Oxidase / Q000145:classification / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D012641:Selection, Genetic; D012782:Shoulder / Q000502:physiology*; D013315:Stress, Psychological / Q000201:enzymology / Q000503:physiopathology
D000900:Anti-Bacterial Agents; D003609:Dactinomycin; D008995:Monoamine Oxidase
Monoaminoksidazy mozga krys, selektsionirovannykh na predraspolozhenie k maiatnikoobraznym dvizheniiam golovy i plechevogo poiasa.