[Therapeutic modalities of endometrial carcinoma in stage I and II].
OBJECTIVE
To evaluate the effectiveness of different therapeutic modalities of endometrial carcinoma in stage I and stage II.


METHODS
From 1984 to 1992, 205 patients with endometrial carcinoma in stage I and stage II were treated in our hospital. The clinical and pathological data were analyzed retrospectively. There were 122 cases in stage I and 83 in stage II. According to therapeutic methods, patients could be divided into 4 groups. Group 1 (surgery group): 81 cases; Group 2 (full dose preoperative intracavitary afterloading irradiation, A point 45G y +/- 10%, F point 50 Gy +/- 10%): 62 cases; Group 3 (non-full dose preoperative intracavitary afterloading irradiation, doses at both point A and point F less than 1/2 of full dose mentioned above): 36 cases; Group 4 (radiotherapy alone): 26 cases. There were no significant differences in pathological type, differential grade, median age and operative methods among the 4 groups.


RESULTS
The 5-year survival rate of group 1 to group 4 was 83.1%, 96.5%, 84.8% and 62.5% respectively in stage I, and 82.0%, 90.9%, 51.4% and 62.7% respectively in stage II. The 5-year survival rate was significantly higher in group 2 (P < 0.05).


CONCLUSIONS
The results suggested that operation combined with full dose preoperative intracavitary afterloading irradiation provided the best therapeutic effect, whereas non-full dose preoperative intracavitary afterloading irradiation showed none of benefit.
Sun
J
J
Cancer Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing.
Sheng
X
X
Chou
Z
Z
D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D000231:Adenocarcinoma, Papillary / Q000401:mortality / Q000628:therapy; D000328:Adult; D000368:Aged; D001918:Brachytherapy / Q000379:methods; D003131:Combined Modality Therapy; D016889:Endometrial Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D015996:Survival Rate