Pregnancy after liver transplantation.
This article reviews the reported experience with pregnancy after liver transplantation and describes obstetric risks and medical issues that the maternal fetal medicine specialist has a reference for managing these pregnancies and for providing appropriate preconception counseling. Women who undergo liver transplantations have a higher risk of preeclampsia, worsening hypertension, preterm premature rupture of membranes, anemia, small for gestational age, preterm delivery, and cesarean section than the normal obstetric population. Women with preconceptional renal dysfunction appear to be at greatest risk for pregnancy complications. Women who conceived within 6 months of transplant had a high risk of rejection. Reproductive-aged recipients of liver allograft should receive contraception and preconception counseling. In an appropriately timed and planned pregnancy, women who undergo liver transplantations can have successful pregnancies with little risk to their allograft function.
Casele
H L
HL
Division of Maternal Fetal Medicine, Northwestern University Medical School, Evanston Hospital, IL 60201, USA.
Laifer
S A
SA
D003267:Contraception; D003376:Counseling; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007226:Infant Mortality; D007231:Infant, Newborn; D016031:Liver Transplantation / Q000009:adverse effects*; D049590:Postpartum Period; D011247:Pregnancy; D011256:Pregnancy Outcome; D012307:Risk Factors
D007166:Immunosuppressive Agents