title: Serotonin-immune interactions in detoxified chronic alcoholic patients without apparent liver disease: activation of the inflammatory response system and lower plasma total tryptophan.
abstract: The aims of the present study were to examine (1) the inflammatory response system (IRS), through measurements of serum interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), sgp130 (the soluble form of the IL-6 transducer signal protein), CC16 (Clara Cell protein; an endogenous anti-cytokine), IL-1R antagonist (IL-1RA), IL-8 and sCD14; and (2) the availability of plasma total tryptophan to the brain in chronic alcoholic patients without apparent liver disease (AWLD). Detoxified AWLD patients had significantly lower plasma tryptophan and serum CC16 and significantly higher serum IL-1RA and IL-8 concentrations than normal volunteers. There were significant correlations between the availability of tryptophan to the brain and serum IL-6, IL-8 and IL-1RA (all negative) and CC16 (positive). The results suggest that (1) there is, in detoxified AWLD patients, an activation of the monocytic arm of cell-mediated immunity and a lowered anti-inflammatory capacity of the serum; and that (2) lower availability of plasma tryptophan to the brain in detoxified AWLD patients is related to activation of the IRS. Lower CC16 may be one factor predisposing chronic alcoholic patients toward infectious disorders.
authors.affiliation: University Department of Psychiatry, Clinical Research Center for Mental Health, Antwerp, Belgium. m.maes@unicall.be
authors.forename: M
authors.initials: M
authors.lastname: Maes
authors.forename: A
authors.initials: A
authors.lastname: Lin
authors.forename: E
authors.initials: E
authors.lastname: Bosmans
authors.forename: E
authors.initials: E
authors.lastname: Vandoolaeghe
authors.forename: S
authors.initials: S
authors.lastname: Bonaccorso
authors.forename: G
authors.initials: G
authors.lastname: Kenis
authors.forename: R
authors.initials: R
authors.lastname: De Jongh
authors.forename: R
authors.initials: R
authors.lastname: Verkerk
authors.forename: C
authors.initials: C
authors.lastname: Song
authors.forename: S
authors.initials: S
authors.lastname: Scharpé
authors.forename: H
authors.initials: H
authors.lastname: Neels
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000097:blood / Q000276:immunology* / Q000503:physiopathology; D015703:Antigens, CD / Q000097:blood; D050822:Cytokine Receptor gp130; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D053590:Interleukin 1 Receptor Antagonist Protein; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D018950:Lipopolysaccharide Receptors / Q000097:blood; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood; D011506:Proteins / Q000032:analysis; D019947:Receptors, Interleukin-6 / Q000097:blood; D012701:Serotonin / Q000276:immunology*; D012795:Sialoglycoproteins / Q000097:blood; D014364:Tryptophan / Q000097:blood*; D014598:Uteroglobin
chemical_list: D015703:Antigens, CD; C507763:IL1RN protein, human; C494199:IL6ST protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D015850:Interleukin-6; D016209:Interleukin-8; D018950:Lipopolysaccharide Receptors; D008562:Membrane Glycoproteins; D011506:Proteins; D019947:Receptors, Interleukin-6; C556389:SCGB1A1 protein, human; D012795:Sialoglycoproteins; D050822:Cytokine Receptor gp130; D012701:Serotonin; D014364:Tryptophan; D014598:Uteroglobin