No serotonin 5-HT2A receptor density abnormality in the cortex of schizophrenic patients studied with PET.
To investigate putative abnormalities of cortical 5-HT2A receptor density in schizophrenia, we used positron emission tomography and [18F]setoperone, a high-affinity 5-HT2A receptor radioligand, in 14 neuroleptic-free or -naive schizophrenic patients and in 15 normal controls. No significant difference between the groups was observed in the whole or regional cortical binding potential of [18F]setoperone, indicating an absence of major 5-HT2A receptor cortical density abnormalities in schizophrenics.
Trichard
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C
INSERM U334, S.H.F.J., DRM, DSV, CEA, Orsay, France.
Paillère-Martinot
M L
ML
Attar-Levy
D
D
Blin
J
J
Feline
A
A
Martinot
J L
JL
D000328:Adult; D002452:Cell Count; D002540:Cerebral Cortex / Q000000981:diagnostic imaging* / Q000378:metabolism*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D011744:Pyrimidinones / Q000493:pharmacokinetics; D011985:Receptors, Serotonin / Q000378:metabolism*; D012559:Schizophrenia / Q000000981:diagnostic imaging* / Q000378:metabolism*; D014055:Tomography, Emission-Computed
D011744:Pyrimidinones; D011985:Receptors, Serotonin; C045359:setoperone