Repeated mazindol and methamphetamine administration produces cross-sensitization to stereotyped behavior induced by these agents in rats.
The cross-sensitization to stereotyped behavior between mazindol (MZD) and methamphetamine (MAP) was investigated in rats. MZD (5 and 10 mg/kg/day, p.o.), MAP (5 and 10 mg/kg/day, p.o.) and saline (1 ml/kg, p.o.) were administered once daily for a week. Challenge with MZD (10 mg/kg, p.o.) on the 8th day caused markedly stereotyped behavior in MAP-pretreated group compared with the saline-pretreated control group. MAP (10 mg/kg, p.o.)-induced stereotyped behavior on the 8th day was also greater in MZD-pretreated group rather than the saline-pretreated control group. These results suggest that repeated MZD and MAP administration cross-sensitizes to their stereotype-producing effects.
Kawakami
Y
Y
Division of Pharmacy, Misasa Medical Branch, Okayama University Medical School, Tottori, Japan.
Suemaru
K
K
Araki
H
H
Kawasaki
H
H
Gomita
Y
Y
Tanizaki
Y
Y
D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology*; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology*; D004334:Drug Administration Schedule; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D008297:Male; D008454:Mazindol / Q000494:pharmacology*; D008694:Methamphetamine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013239:Stereotyped Behavior / Q000187:drug effects*
D001067:Appetite Depressants; D018765:Dopamine Uptake Inhibitors; D008694:Methamphetamine; D008454:Mazindol