title: Dental extractions in patients on warfarin: is alteration of anticoagulant regime necessary?
abstract: Various clinical protocols for the management of warfarinised patients needing dental extractions have been suggested. This study was designed to compare two approaches in the management of these patients. A control group of 32 patients had their warfarin treatment stopped for 2-3 days prior to having dental extractions, resulting in a reduction in the average preoperative international normalised ratio (INR) from 2.6 to 1.6. The study group of 33 patients did not have their anticoagulant treatment altered before extractions, and had an average preoperative INR of 2.7. All patients were treated under local analgesia on an outpatient basis, and local measures-consisting of Surgicel pack and sutures-were used in all cases to control postoperative bleeding from extraction sockets. None of the patients had any immediate postoperative bleeding, and only 1 patient from each group had mild delayed haemorrhage, which was easily controlled with local measures. It is proposed that, provided the INR is within the therapeutic range of 2.0 to 4.0 and local measures are used to control postoperative bleeding, there is no justification in altering warfarin treatment prior to dental extractions in these patients, and thereby exposing them to the risk of thromboembolism.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Queen Victoria Hospital, East Grinstead, West Sussex, UK.
authors.forename: P
authors.initials: P
authors.lastname: Devani
authors.forename: K M
authors.initials: KM
authors.lastname: Lavery
authors.forename: C J
authors.initials: CJ
authors.lastname: Howell
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000556:Ambulatory Surgical Procedures / Q000379:methods; D016022:Case-Control Studies; D002985:Clinical Protocols; D017742:Dental Care for Chronically Ill; D006801:Humans; D019934:International Normalized Ratio; D008875:Middle Aged; D019106:Postoperative Hemorrhage / Q000209:etiology / Q000517:prevention & control; D014081:Tooth Extraction / Q000009:adverse effects; D014859:Warfarin / Q000008:administration & dosage*
chemical_list: D014859:Warfarin