Limited CD4+ T-cell renewal in early HIV-1 infection: effect of highly active antiretroviral therapy.
We show that the fraction of proliferating CD4+ lymphocytes is similar in HIV-infected subjects in the early stage of disease and in HIV-negative subjects, whereas the fraction of proliferating CD8+ lymphocytes is increased 6.8-fold in HIV-infected subjects. After initiation of antiviral therapy, there is a late increase in proliferating CD4+ T cells associated with the restoration of CD4+ T-cell counts. These results provide strong support for the idea of limited CD4+ T-cell renewal in the early stage of HIV infection and indicate that after effective suppression of virus replication, the mechanisms of CD4+ T-cell production are still functional in early HIV infection.
Fleury
S
S
Department of Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland.
de Boer
R J
RJ
Rizzardi
G P
GP
Wolthers
K C
KC
Otto
S A
SA
Welbon
C C
CC
Graziosi
C
C
Knabenhans
C
C
Soudeyns
H
H
Bart
P A
PA
Gallant
S
S
Corpataux
J M
JM
Gillet
M
M
Meylan
P
P
Schnyder
P
P
Meuwly
J Y
JY
Spreen
W
W
Glauser
M P
MP
Miedema
F
F
Pantaleo
G
G
D000328:Adult; D000368:Aged; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D016516:CD4-CD8 Ratio; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002219:Carbamates; D002455:Cell Division; D015224:Dideoxynucleosides / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005663:Furans; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology*; D017320:HIV Protease Inhibitors / Q000627:therapeutic use*; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D008198:Lymph Nodes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use*; D013449:Sulfonamides / Q000627:therapeutic use*; D000099227:Abacavir
D019380:Anti-HIV Agents; D002219:Carbamates; D015224:Dideoxynucleosides; D005663:Furans; D017320:HIV Protease Inhibitors; D019394:Ki-67 Antigen; D018894:Reverse Transcriptase Inhibitors; D013449:Sulfonamides; D000099227:Abacavir; C095108:amprenavir