General stress transcription factor sigmaB and sporulation transcription factor sigmaH each contribute to survival of Bacillus subtilis under extreme growth conditions.
The general stress response of the bacterium Bacillus subtilis is controlled by the sigmaB transcription factor. Here we show that loss of sigmaB reduces stationary-phase viability 10-fold in either alkaline or acidic media and reduces cell yield in media containing ethanol. We further show that loss of the developmental transcription factor sigmaH also has a marked effect on stationary-phase viability under these conditions and that this effect is independent from the simple loss of sporulation ability.
Gaidenko
T A
TA
Department of Food Science and Technology, University of California, Davis, California 95616, USA.
Price
C W
CW
D000891:Anti-Infective Agents, Local / Q000494:pharmacology; D001412:Bacillus subtilis / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D001426:Bacterial Proteins / Q000187:drug effects / Q000502:physiology*; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D015169:Colony Count, Microbial; D000431:Ethanol / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D012808:Sigma Factor / Q000187:drug effects / Q000502:physiology*; D013171:Spores, Bacterial / Q000235:genetics; D014157:Transcription Factors / Q000502:physiology*
D000891:Anti-Infective Agents, Local; D001426:Bacterial Proteins; C079011:SigB protein, Bacteria; D012808:Sigma Factor; D014157:Transcription Factors; D000431:Ethanol