title: [Choroid neovascularization in age-related macular degeneration. Correlation of histological and fluorescence angiography findings].
abstract: BACKGROUND
  Recent studies have raised confusion about the fluorescein angiographical and histopathological correlation of CNV.
  
  
  METHODS
  The preoperative fluorescein angiograms of four patients with subfoveal CNV due to ARMD extracted by pars plana vitrectomy were classified as wellor ill-defined CNV and were correlated to the histopathologically (in serial sections) verrified CNV-location (subneuroretinal (= type II according to Gass) versus sub-RPE (type I according to Gass)).
  
  
  RESULTS
  The locations of all four CNV could be classified by histopathological landmarks as there were RPE, BLD/drusen, and inner Bruchs membrane. Angiographically welldefined membranes were type II membranes according to Gass, whereas the ill-defined membrane represented type I. The CNV with well- and ill-defined borders consisted of type II and type I parts according to Gass.
  
  
  CONCLUSIONS
  We find subneuroretinal locations of the well-defined CNV examined (type II membranes according to Gass). Correspondingly, ill-defined CNV or ill-defined parts of a CNV seem to be beneath the RPE (type I). The correlation of fluorescein angiography and histopathology should be studied in greater numbers of well- and ill-defined CNV.
authors.affiliation: Augenklinik der Ludwig-Maximilians-Universität München.
authors.forename: J P
authors.initials: JP
authors.lastname: Hoops
authors.forename: A
authors.initials: A
authors.lastname: Scheider
authors.forename: E M
authors.initials: EM
authors.lastname: Messmer
authors.forename: T
authors.initials: T
authors.lastname: Grasbon
authors.forename: O
authors.initials: O
authors.lastname: Gündisch
authors.forename: A
authors.initials: A
authors.lastname: Kampik
mesh_terms: D016570:Bruch Membrane / Q000473:pathology; D002829:Choroid / Q000098:blood supply*; D005451:Fluorescein Angiography; D006801:Humans; D008268:Macular Degeneration / Q000175:diagnosis* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000175:diagnosis* / Q000473:pathology; D010857:Pigment Epithelium of Eye / Q000473:pathology; D015593:Retinal Drusen / Q000473:pathology; D012166:Retinal Hemorrhage / Q000175:diagnosis / Q000473:pathology
vernacular_title: Chorioidale Neovaskularisationen bei AMD. Korrelation histologischer und fluoreszenzangiographischer Befunde.