title: Can a total knee replacement prosthesis be made entirely of polymers?
abstract: We have prospectively studied 63 total knee replacements (TKR) in which the femoral component was polyacetal, and 138 TKRs in which the femoral component was conventional cobalt chrome. The tibial and patellar components were of ultrahigh molecular weight polyethylene (UHMWPE). Patients were followed-up for at least 10 years. In the polyacetal group, a number of patients have died or have been revised, for reasons unrelated to the presence of polyacetal. There were no instances of femoral component fracture, nor failure by wear. One postmortem specimen, retrieved at 9 years after surgery, showed no measurable polyacetal wear and negligible HDP wear. The histology of tissue in contact with polyacetal was indistinguishable from that adjacent to polymethyl methacrylate and UHMWPE in the same knee. We believe that polyacetal could be used for the femoral component of a TKR and that a further trial should be undertaken.
authors.affiliation: The Royal London Hospital, England.
authors.forename: D J
authors.initials: DJ
authors.lastname: Moore
authors.forename: M A
authors.initials: MA
authors.lastname: Freeman
authors.forename: P A
authors.initials: PA
authors.lastname: Revell
authors.forename: G W
authors.initials: GW
authors.lastname: Bradley
authors.forename: M
authors.initials: M
authors.lastname: Tuke
mesh_terms: D000080:Acetals; D019645:Arthroplasty, Replacement, Knee / Q000295:instrumentation*; D001672:Biocompatible Materials; D002858:Chromium Alloys; D003035:Cobalt; D016001:Confidence Intervals; D005500:Follow-Up Studies; D006801:Humans; D007720:Knee Prosthesis; D015993:Life Tables; D011095:Polyethylenes; D011108:Polymers; D011446:Prospective Studies; D011474:Prosthesis Design; D011475:Prosthesis Failure; D015996:Survival Rate
chemical_list: D000080:Acetals; D001672:Biocompatible Materials; D002858:Chromium Alloys; D011095:Polyethylenes; D011108:Polymers; C016067:polyacetal; D003035:Cobalt