[Common variable immunodeficiency in adults and problems of its immunotherapy].
OBJECTIVE
Clinicoimmunological study of adult patients with prevailing defect of humoral immunity, development of diagnostic criteria and treatment of this disease.


METHODS
Clinical, immunological and microbiological examinations were made in 68 patients with defects of antibody formation.


RESULTS
Total variable immunodeficiency (TVID), selective deficiency of IgA, congenital agammaglobulinemia, hyper-IgM-syndrome were detected in 74, 13, 10 and 3% of patients, respectively. TVID was frequently associated with respiratory, chronic ENT and gastrointestinal diseases, low CD4+ and high CD8+ levels. The response was achieved with combined therapy: antibacterial treatment + immunocorrection + differentiated replacement with plasma or immunoglobulins.


CONCLUSIONS
In choice of immunotherapy of TVID patients it is necessary to consider parameters of immunogram. Intravenous administration of immunoglobulin preparations provided the highest effect in good safety.
Borisova
A M
AM
Setdikova
N Kh
NKh
Kaliazina
V A
VA
Malashenkova
E V
EV
Varfolomeeva
M I
MI
D000293:Adolescent; D000328:Adult; D000917:Antibody Formation / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D016913:Blood Component Transfusion; D016516:CD4-CD8 Ratio; D017074:Common Variable Immunodeficiency / Q000097:blood / Q000276:immunology / Q000628:therapy*; D005500:Follow-Up Studies; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007167:Immunotherapy; D008875:Middle Aged; D010949:Plasma; D012074:Remission Induction; D013601:T-Lymphocytes / Q000276:immunology
D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous
Obshchaia variabel'naia immunnaia nedostatochnost' u vzroslykh i problemy ee immunoterapii.