Differences in the immune response during the acute phase of E-55+ murine leukemia virus infection in progressor BALB and long term nonprogressor C57BL mice.
E-55+ murine leukemia virus infection of both progressor (BALB) and long term nonprogressor (C57BL) mouse strains is characterized by an acute and a persistent phase of infection. During the acute phase, progressor strains require CD8+ T cells to decrease virus burden, whereas the long term nonprogressor strains do not. In the present studies the immune response in BALB and C57BL mice during the acute phase of E-55+ murine leukemia virus infection was examined. The results demonstrate that BALB mice produce both IL-4 and IFN-gamma, in contrast to C57BL mice, which produce only IFN-gamma. In BALB mice, IL-4 production results in the absolute requirement for CD8+ T cells to reduce the virus burden during the acute phase of infection. The anti-virus immune response in these mice is IFN-gamma dependent. On the other hand, C57BL mice do not produce IL-4 and, in the absence of both CD8+ T cells and IFN-gamma, still generate an effective anti-virus immune response. Genetic studies suggest that these distinct immune responses are regulated by more than one non-MHC-linked gene. Two candidate regions that may encode this gene(s), located on chromosomes 7 and 19, respectively, were identified by recombinant inbred strain linkage analysis.
Panoutsakopoulou
V
V
Department of Pathology, Allegheny University of the Health Sciences, Philadelphia, PA 19102, USA.
Little
C S
CS
Sieck
T G
TG
Blankenhorn
E P
EP
Blank
K J
KJ
D000208:Acute Disease; D000818:Animals; D016207:Cytokines / Q000096:biosynthesis; D004198:Disease Susceptibility; D008040:Genetic Linkage; D007113:Immunity, Innate; D007371:Interferon-gamma / Q000502:physiology; D015847:Interleukin-4 / Q000096:biosynthesis / Q000502:physiology; D009052:Leukemia Virus, Murine / Q000276:immunology*; D007942:Leukemia, Experimental / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D008285:Major Histocompatibility Complex / Q000235:genetics / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D012192:Retroviridae Infections / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D014412:Tumor Virus Infections / Q000235:genetics / Q000276:immunology* / Q000378:metabolism
D016207:Cytokines; D015847:Interleukin-4; D007371:Interferon-gamma