title: Intravascular imaging.
abstract: Based on three-dimensional (3D) information, quantitative data such as plaque volume can be calculated. The procedure includes automatic contour detection based in image segmentation methods and greatly speeds up clinical evaluation. With the use of additional X-ray information, the true tortuous vessel geometry can be reconstructed in 3D. This allows, by numerical modelling techniques, to calculate endothelial shear stress values which in turn may indicate sites prone to stenosis. With a decorrelation technique for radio frequency (RF) echo information from sequential data in the same beam direction and integration method over the entire cross section, blood velocity can be shown colour-coded during the cardiac cycle, while even blood flow quantification seems to be possible. In vitro as well as animal experiments have shown the feasibility of the method. Intravascular imaging can be used to study the biomechanical properties of atheroma components. Local radial strain as a measure of local tissue hardness can be estimated in principle. Hard or soft plaques can be identified from the strain images independently of the echogenic contrast between plaque and vessel wall.
authors.affiliation: Thoraxcentre, Erasmus University Rotterdam, The Netherlands. bom@tch.fgg.eur.nl
authors.forename: N
authors.initials: N
authors.lastname: Bom
authors.forename: W
authors.initials: W
authors.lastname: Li
authors.forename: A F
authors.initials: AF
authors.lastname: van der Steen
authors.forename: C T
authors.initials: CT
authors.lastname: Lancée
authors.forename: E I
authors.initials: EI
authors.lastname: Céspedes
authors.forename: C J
authors.initials: CJ
authors.lastname: Slager
authors.forename: C L
authors.initials: CL
authors.lastname: de Korte
mesh_terms: D000792:Angiography; D000818:Animals; D001157:Arterial Occlusive Diseases / Q000209:etiology / Q000503:physiopathology; D001161:Arteriosclerosis / Q000000981:diagnostic imaging; D001783:Blood Flow Velocity / Q000502:physiology; D001808:Blood Vessels / Q000000981:diagnostic imaging*; D003198:Computer Simulation; D004198:Disease Susceptibility; D004548:Elasticity; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging / Q000503:physiopathology; D005240:Feasibility Studies; D006244:Hardness; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D008955:Models, Cardiovascular; D013314:Stress, Mechanical; D018084:Ultrasonography, Interventional / Q000295:instrumentation / Q000379:methods