title: Management of cervical intraepithelial neoplasia of the uterine cervix: 110 cases treated by cold-knife conization.
abstract: OBJECTIVE
  The purpose of this study was to evaluate treatment by cold-knife-conization in women carriers of cervical intraepithelial neoplasia (CIN).
  
  
  METHODS
  The histologic findings of pre-clinical neoplasia of the cervix after conization were compared to the previous findings of cytology, colposcopy and punch-biopsy in 110 women examined between 1985 and 1995. The chi square test (chi2) was used for the statistical analysis.
  
  
  CONCLUSIONS
  A close correlation is clinically important where complementary roles of these three methods are used to identify lesions suitable for local ablative therapy. The Pap test alone is no longer sufficient for the screening of the pre-cancerous lesion of the cervix and colposcopy is compulsory each time the smear is inadequate or altered. Conization permitted us to single out 13 (11.8%) cases of carcinoma. After cold-knife conization we had six (5.4%) recurrences within two years and two (1.8%) within three years. Our data show that conservative therapy by conization in women with CIN reduces the risk of invasive cancer of the cervix but careful follow-up of these patients is essential.
authors.affiliation: Institute of Gynaecology and Obstetrics, Catholic University of Sacred Heart, Rome, Italy.
authors.forename: P A
authors.initials: PA
authors.lastname: Margariti
authors.forename: G
authors.initials: G
authors.lastname: Balsamo
authors.forename: G
authors.initials: G
authors.lastname: Gullotta
authors.forename: C
authors.initials: C
authors.lastname: Rabitti
authors.forename: D
authors.initials: D
authors.lastname: Valle
authors.forename: S
authors.initials: S
authors.lastname: Mancuso
mesh_terms: D000328:Adult; D019092:Conization; D005260:Female; D006801:Humans; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000601:surgery*; D002578:Uterine Cervical Dysplasia / Q000473:pathology / Q000601:surgery*