Effect of temperature and some common metals on the stability of volatile anaesthetic-Entonox mixtures.
Thermal stability of pressurised ready-to-use volatile liquid anaesthetic mixtures (halothane, isoflurane and enflurane) in Entonox (commercially available premixed 50% N2O, 50% O2 mixture) were investigated at temperatures of 20, 258, 400, 503 and 602 degrees C on glass, stainless steel, copper and aluminium by gas chromatography and GC-MS. It was found that most of the decomposition products formed were halogenated compounds and the observed thermal stabilities in glass, stainless steel and copper allowed a thermal treatment up to 250 degrees C without any decomposition problem. Aluminium was found to be the most effective metal at causing decomposition of the anaesthetic mixtures even at lower temperatures.
Uyanik
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Ondokuz Mayis Universitesi, Fen-Edebiyat Fakültesi, Kimya Bölümü, Kurupelit, Samsun, Turkey.
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D000535:Aluminum; D019162:Anesthetics, Combined / Q000737:chemistry*; D018685:Anesthetics, Inhalation / Q000737:chemistry*; D003300:Copper; D004355:Drug Stability; D004737:Enflurane / Q000737:chemistry; D008401:Gas Chromatography-Mass Spectrometry; D005898:Glass; D006221:Halothane / Q000737:chemistry; D006358:Hot Temperature; D007530:Isoflurane / Q000737:chemistry; D009609:Nitrous Oxide / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry*; D013232:Steel
D019162:Anesthetics, Combined; D018685:Anesthetics, Inhalation; D013232:Steel; C001147:Entonox; D003300:Copper; D004737:Enflurane; D000535:Aluminum; D007530:Isoflurane; D009609:Nitrous Oxide; D010100:Oxygen; D006221:Halothane