[Renin-angiotensin system: involvement in polycystic ovarian syndrome].
OBJECTIVE
To investigate the relationship between renin-angiotensin system (RAS) and polycystic ovarian syndrome (PCOS) METHODS: A pituitary-stimulating test with luteinizing hormone releasing hormone (LRH, 100 micrograms) was performed in two PCOS groups with similar mean testosteron (T) levels of luteinizing hormone/follicular stimulating hormone (LH/FSH) (LH/FSH > or = 3, group 1, n = 15; LH/FSH < 3, group 2, n = 15) and the controls (n = 20) of matched body mass index with group 1. The basal level and LRH-evoked responses of LH, plasma renin activity (PRA), angiotensin II (AT II ) and aldosterone (ALD) were measured by RIA with commercially available kits. In the basal state, a positive correlation was found between T and AT II levels (r = 0. 49, P < 0.05) in all PCOS subjects. After LRH administration, susceptible individuals, especially of group 1 had exaggerated responses of LH, PRA, AT II and ALD as compared with the controls, and a positive correlation was also found between peak levels of LH and AT II (r = 0.54, P < 0.01).


CONCLUSIONS
There is enhanced RAS function in PCOS especially in group 1. This may contribute to the excess androgen production and high incidence of ovarian hyperstimulation syndrome in this disorder.
Wu
X
X
Nanjing Jinling Hospital.
Lu
K
K
Su
Y
Y
D000328:Adult; D005260:Female; D006801:Humans; D007986:Luteinizing Hormone / Q000378:metabolism; D010053:Ovary / Q000503:physiopathology; D011085:Polycystic Ovary Syndrome / Q000378:metabolism*; D012084:Renin-Angiotensin System / Q000502:physiology*; D013739:Testosterone / Q000378:metabolism
D013739:Testosterone; D007986:Luteinizing Hormone