title: Provisional quantitative trait loci (QTL) for the Aschoff effect in RI mice.
abstract: Mice of the CXB recombinant inbred (RI) panel were phenotyped for period of locomotor activity in continuous dark (tau) and in continuous 10-lux light (tauLL). There were significant differences in the effect of light on period, delta tau (tauLL-tau), among CXB RI strains and their progenitors. By comparing strain means for delta tau in the CXB RI strains with typed genetic loci using a product moment correlation, it was possible to hypothesize quantitative trait loci (QTL) important to the genetic variance in the effect of constant low-level light on circadian period. Some of the candidate genes linked to statistically associated markers are neuropharmacologically interesting. Provisional QTL for delta tau were found on proximal Chromosome 8 and mid Chromosome 11 in regions near QTL identified in a similar analysis of the BXD RI panel. This provides additional evidence for the importance of loci on Chromosomes 8 and 11.
authors.affiliation: Roudebush VA Medical Center, Department of Veteran Affairs, Indianapolis, IN 46202, USA. JHOFSTET@iupui.edu
authors.forename: J R
authors.initials: JR
authors.lastname: Hofstetter
authors.forename: A R
authors.initials: AR
authors.lastname: Mayeda
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D002940:Circadian Rhythm / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D008027:Light; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C / Q000235:genetics*; D008810:Mice, Inbred C57BL / Q000235:genetics*; D015999:Multivariate Analysis; D017440:Photoperiod; D019655:Quantitative Trait, Heritable; D013045:Species Specificity; D013223:Statistics as Topic
chemical_list: D005819:Genetic Markers