title: Effects of gonadotropin and testosterone treatments on plasma leptin levels in male patients with idiopathic hypogonadotropic hypogonadism and Klinefelter's syndrome.
abstract: Since little is known about the effects of gonadotropin and testosterone treatment on leptin levels in male hypogonadism, we determined fasting plasma leptin levels before and 3 months after treatment in 21 patients with idiopathic hypogonadotropic hypogonadism (IHH), 16 patients with Klinefelter's syndrome and 20 male controls. Patients with IHH were treated with hCG/human menopausal gonadotropin, whereas patients with Klinefelter's syndrome received T treatment. Plasma leptin levels were measured by an RIA with a sensitivity of 0.5 microg/L. Mean leptin levels in patients with IHH before treatment (9.23+/-4.09 microg/L) were not significantly different from those in patients with Klinefelter's syndrome (7.29+/-5.05 microg/L; z=-1.41; P=0.15). Leptin levels in both IHH and Klinefelter's syndrome groups were, however, significantly higher than in the normal men (3.91+/-1.67 microg/L) (P<0.001 and P<0.01, respectively). Mean leptin levels did not change significantly 3 months after the initiation of gonadotropin (11.6+/-6.44 microg/L) or T (8.32+/-5.17 microg/L) treatment in either IHH or Klinefelter's syndrome. Our study demonstrated that mean plasma leptin levels are not influenced by short-term gonadotropin or T treatment in male hypogonadism.
authors.affiliation: Department of Endocrinology, Gulhane School of Medicine Etik, Ankara, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Ozata
authors.forename: G
authors.initials: G
authors.lastname: Ozisik
authors.forename: S
authors.initials: S
authors.lastname: Caglayan
authors.forename: Z
authors.initials: Z
authors.lastname: Yesilova
authors.forename: N
authors.initials: N
authors.lastname: Bingöl
authors.forename: M
authors.initials: M
authors.lastname: Saglam
authors.forename: M
authors.initials: M
authors.lastname: Turan
authors.forename: Z
authors.initials: Z
authors.lastname: Beyhan
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage*; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007713:Klinefelter Syndrome / Q000188:drug therapy* / Q000378:metabolism*; D020738:Leptin; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D011388:Prolactin / Q000097:blood; D011506:Proteins / Q000378:metabolism*; D013737:Testis / Q000473:pathology; D013739:Testosterone / Q000008:administration & dosage*
chemical_list: D006063:Chorionic Gonadotropin; D020738:Leptin; D011506:Proteins; D013739:Testosterone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone