Effects of a combined thermochemotherapy on the xenotransplanted human mammary carcinoma MX-1. A light and transmission electron microscopic study.
A thermochemotherapy (TCT), consisting of the administration of the alkylating agent ifosfamide combined with whole body hyperthermia at 41 degrees C for one hour applied to the xenotransplanted human mammary carcinoma MX-1, leads to a complete remission within one week. This light and transmission electron microscopical study concentrates upon the mechanisms of cell death and upon therapy-induced changes in vasculature. These showed that TCT produces necrotic rather than apoptotic cell death in xenotransplanted MX-1 tumors, whereas apoptosis of endothelial cells was often found. We therefore conclude from our experiments that TCT is a very powerful stimulus which directly impels MX-1 cells towards coagulative necrosis, while endothelial cells, being probably more resistant, often die by apoptosis.
Stobbe
E M
EM
Institut für Anatomie, Medizinische Universität zu Lübeck, Germany.
D000818:Animals; D001943:Breast Neoplasms / Q000473:pathology* / Q000628:therapy / Q000648:ultrastructure; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D007069:Ifosfamide / Q000627:therapeutic use*; D051379:Mice; D008819:Mice, Nude; D008854:Microscopy, Electron; D014183:Transplantation, Heterologous
D007069:Ifosfamide