[Comparison of 51Cr-EDTA with 99m-Tc-DTPA slope clearance for estimation of glomerular filtration rate using the one compartment model].
OBJECTIVE
Of this study is to determine the relationship between 51Cr-EDTA and 99mTc-DTPA slope clearance applying the "one-compartment model".


METHODS
The "one-compartment model" was chosen to calculate and to compare the glomerular filtration rates of 25 patients with normal and pathological creatinin values after injection of 51Cr-EDTA and 99mTc-DTPA simultaneously.


RESULTS
The two clearance values correlated well (r = 0.996), and the 99mTc-DTPA clearance was systematically higher (28%). The 99mTc-DTPA was calculated and compared after taking three plasma samples. Taking two samples, only minor differences were seen and the correlation was high (r = 0.992).


CONCLUSIONS
The results of this study encouraged us to adopt the use of 99mTc-DTPA instead of 51Cr-EDTA in determining the glomerular filtration applying the "one-compartment model" in slope with two plasma samples.
Chapot
C
C
Universitätskliniken des Saarlandes, Radiologische Klinik, Deutschland.
Seifert
H
H
Samnick
S
S
Kirsch
C M
CM
D002860:Chromium Radioisotopes / Q000097:blood / Q000493:pharmacokinetics; D004492:Edetic Acid; D005919:Glomerular Filtration Rate; D006801:Humans; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D019275:Radiopharmaceuticals / Q000097:blood / Q000493:pharmacokinetics; D012044:Regression Analysis; D016284:Technetium Tc 99m Pentetate / Q000097:blood / Q000493:pharmacokinetics
D002860:Chromium Radioisotopes; D019275:Radiopharmaceuticals; D004492:Edetic Acid; D016284:Technetium Tc 99m Pentetate
Vergleich der 51Cr-EDTA-mit der 99mTc-DTPA-Slope-Clearance zur Bestimmung der glomerulären Filtrationsrate nach dem Ein-Kompartiment-Modell.