JAK/STAT signaling by cytokine receptors.
The JAK/STAT pathway is recognized as one of the major mechanisms by which cytokine receptors transduce intracellular signals. This system is regulated at multiple levels, including JAK activation, nuclear trafficking of STAT factors, and negative feedback loops. Gene deletion studies have implicated selected STAT factors as predominant mediators for a limited number of lymphokines. This signaling pathway influences normal cell survival and growth mechanisms and may contribute to oncogenic transformation.
Liu
K D
KD
Gladstone Institute of Virology and Immunology, San Francisco, California 94141, USA.
Gaffen
S L
SL
Goldsmith
M A
MA
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002471:Cell Transformation, Neoplastic; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D019281:Dimerization; D005246:Feedback; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology*; D018390:Gene Targeting; D005804:Genes, Lethal; D007372:Interferons / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D011505:Protein-Tyrosine Kinases / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D018121:Receptors, Cytokine / Q000187:drug effects / Q000502:physiology*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D015534:Trans-Activators / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D018909:src Homology Domains
D004268:DNA-Binding Proteins; D018121:Receptors, Cytokine; D015534:Trans-Activators; D007372:Interferons; D011505:Protein-Tyrosine Kinases