Amino acid transport in cerebral microvessels during Plasmodium yoelii infection in mice.
Plasmodium yoelii infected cerebral microvessels of mice had an enhanced time-dependent, temperature-sensitive, and saturable uptake of [14C]-amino acid. viz. leucine, valine and glycine. Metabolic inhibitors caused a noticeable inhibition of amino acid uptake in normal microvessels as compared to infected cerebral microvessels indicating that the uptake of [14C]-L-leucine, [14C]-L-valine and [14C]-glycine is an energy dependent process.
Agrawal
A
A
Division of Biochemistry, Central Drug Research Institute, Lucknow, India.
Tripathi
L M
LM
Pandey
V C
VC
D000596:Amino Acids / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics*; D000818:Animals; D001692:Biological Transport / Q000502:physiology; D002196:Capillaries / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005998:Glycine / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics; D007930:Leucine / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics; D008288:Malaria / Q000378:metabolism*; D051379:Mice; D009994:Osmolar Concentration; D010967:Plasmodium yoelii; D012016:Reference Values; D013696:Temperature; D014633:Valine / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics
D000596:Amino Acids; D007930:Leucine; D014633:Valine; D005998:Glycine