Polymorphism of the platelet glycoprotein IIIa gene in patients with coronary stenosis.
Based on genetic variability, structural differences in the glycoprotein IIb/IIIa platelet receptor for adhesive proteins result in individual differences in the thrombogenicity of platelets. Recent studies suggest a controversial association between a genetic polymorphism of the glycoprotein IIIa gene (PlA2) and the risk of coronary artery disease. In our study, the prevalence of the PlA2 allele in a group of patients undergoing percutaneous coronary revascularization was 37%, a value significantly higher than in controls [13%, odds ratio (OR) = 3.93, 95% CI, 1.84 to 8.53] suggesting a significant association between this polymorphism and documented coronary stenosis, which is strongest among <60 years old patients (OR = 12.30, 95% CI, 2.98 to 70.93). This polymorphism represents an inherited risk factor for severe cardiovascular disease due to coronary occlusion.
Garcia-Ribes
M
M
Nutrition and Cardiovascular Risk Unit, University of Cantabria, Spain. garciami@medi.unican.es
Gonzalez-Lamuño
D
D
Hernandez-Estefania
R
R
Colman
T
T
Pocovi
M
M
Delgado-Rodriguez
M
M
Garcia-Fuentes
M
M
Revuelta
J M
JM
D000368:Aged; D000428:Alcohol Drinking / Q000453:epidemiology; D000483:Alleles; D015906:Angioplasty, Balloon, Coronary; D003131:Combined Modality Therapy; D015897:Comorbidity; D003327:Coronary Disease / Q000453:epidemiology / Q000235:genetics* / Q000601:surgery / Q000628:therapy; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D015995:Prevalence; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology; D015607:Stents
D008055:Lipids; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D005340:Fibrinogen