Acute liver failure caused by isoniazid in a child receiving carbamazepine.
We report a case of a 10-year-old boy, being treated for seizures with carbamazepine, who developed acute liver failure within four days of initiation of therapy for suspected tuberculosis with isoniazid, rifampin, pyrazinamide, and ethambutol. Isoniazid-induced liver disease was diagnosed. The likely role of carbamazepine and rifampin in potentiating the hepatotoxicity of isoniazid, and the importance of early recognition of isoniazid-induced liver disease, are discussed.
Berkowitz
F E
FE
Department of Pediatrics, Emory University School of Medicine, and Pharmacy, Egleston Children's Hospital, Atlanta, Georgia 30303, USA.
Henderson
S L
SL
Fajman
N
N
Schoen
B
B
Naughton
M
M
D000927:Anticonvulsants / Q000009:adverse effects*; D000995:Antitubercular Agents / Q000009:adverse effects*; D002220:Carbamazepine / Q000009:adverse effects*; D002648:Child; D004347:Drug Interactions; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects*; D017114:Liver Failure, Acute / Q000139:chemically induced*; D008297:Male
D000927:Anticonvulsants; D000995:Antitubercular Agents; D002220:Carbamazepine; D007538:Isoniazid