Susceptibility of the anaerobic gram-negative non-sporulating rod, Bilophila wadsworthia to beta-lactams, beta-lactamase inhibitors, meropenem, metronidazole, clindamycin and quinolones.
The susceptibility of eighty-seven strain of Bilophila wadsworthia to five beta-lactams, two beta-lactamase inhibitors, meropenem, metronidazole, clindamycin and two quinolones was determined. Tests were performed by the modified reference agar dilution technique using triphenyltetrazolium chloride for endpoint reading. The test strains showed a reduced susceptibility to the beta-lactams, penicillin G (MIC90 4 micrograms/ml), ampicillin (MIC90 32 micrograms/ml), piperacillin (MIC90 64 micrograms/ml), cephalothin (MIC90 2 micrograms/ml and cefotaxim (MIC90 4 micrograms/ml). The activity of ampicillin was increased by addition of the beta-lactamase inhibitor, sulbactam (MIC90 2 micrograms/ml), as was the activity of piperacillin by the addition of tazobactam (MIC90 4 micrograms/ml) 90.8% of the strains were found to produce beta-lactamase by the nitrocefin tube method. All strains were shown to be highly susceptible to meropenem, metronidazole and clindamycin (MICs < or = 1 microgram/ml). Sparfloxacin (MIC90 1 microgram/ml) and ciprofloxacin (MIC90 0.5 microgram/ml) were found to be active against most of the strains tested.
Schumacher
U K
UK
Abteilung für Medizinische Mikrobiologie, Eberhard-Karls-Universität Tübingen.
Single
B
B
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002981:Clindamycin / Q000494:pharmacology*; D016965:Gram-Negative Anaerobic Straight, Curved, and Helical Rods / Q000187:drug effects*; D000077731:Meropenem; D008795:Metronidazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015363:Quinolones / Q000494:pharmacology*; D013845:Thienamycins / Q000494:pharmacology*; D065093:beta-Lactamase Inhibitors; D047090:beta-Lactams / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D015363:Quinolones; D013845:Thienamycins; D065093:beta-Lactamase Inhibitors; D047090:beta-Lactams; D008795:Metronidazole; D002981:Clindamycin; D000077731:Meropenem