Structural principles in cell-cycle control: beyond the CDKs.
Retinoblastoma protein (Rb) interacts with cyclin-dependent kinases and regulates the transcription of genes necessary for progression through the S phase of the cell cycle. Clues to the atomic mechanisms involved are offered by the structure of the two pocket regions of Rb in complex with a short peptide from a viral oncoprotein. Structures of cyclins, Rb and TFIIB reveal that a common motif occurs in proteins regulating three consecutive events of cell-cycle control.
Endicott
J A
JA
Laboratory of Molecular Biophysics, Oxford, UK.
Noble
M E
ME
D000595:Amino Acid Sequence; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009856:Oncogene Proteins, Viral / Q000737:chemistry / Q000378:metabolism; D027383:Papillomaviridae; D011487:Protein Conformation; D016160:Retinoblastoma Protein / Q000737:chemistry / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D035581:Transcription Factor TFIIB; D014157:Transcription Factors / Q000737:chemistry / Q000378:metabolism
D018797:Cell Cycle Proteins; D009856:Oncogene Proteins, Viral; D016160:Retinoblastoma Protein; D035581:Transcription Factor TFIIB; D014157:Transcription Factors