Freeze-drying of bioproducts: putting principles into practice.
The product and process parameters that determine successful freeze-drying are described and their interrelationships are explored. It is shown that the thermochemical and thermomechanical properties of water-soluble, amorphous materials form the basis of effective formulation design and that coordinated approaches to formulation and process development achieve optimum results with a minimum of trial-and-error experimentation.
Franks
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BioUpdate Foundation, Cambridge, UK. bioup@dial.pipex.com
D001688:Biological Products / Q000737:chemistry*; D004355:Drug Stability; D005612:Freeze Drying / Q000379:methods
D001688:Biological Products