title: Hemopericardium and cardiac tamponade after thrombolysis for acute ischemic stroke.
abstract: Hemorrhage is the major complication of IV recombinant tissue plasminogen activator (rt-PA) treatment for stroke. We report three patients with mild or indistinct cardiac symptoms prior to thrombolysis in whom hemodynamically significant cardiac tamponade occurred after treatment with rt-PA. Acute ischemic stroke patients may have undetected myocardial or pericardial disease that may pose a risk for hemopericardium and life-threatening tamponade after treatment with rt-PA.
authors.affiliation: University of Pennsylvania Medical Center, Philadelphia, USA.
authors.forename: S E
authors.initials: SE
authors.lastname: Kasner
authors.forename: C E
authors.initials: CE
authors.lastname: Villar-Cordova
authors.forename: D
authors.initials: D
authors.lastname: Tong
authors.forename: J C
authors.initials: JC
authors.lastname: Grotta
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000188:drug therapy*; D002305:Cardiac Tamponade / Q000139:chemically induced* / Q000000981:diagnostic imaging; D002561:Cerebrovascular Disorders / Q000188:drug therapy*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008875:Middle Aged; D010490:Pericardial Effusion / Q000139:chemically induced* / Q000000981:diagnostic imaging; D010960:Plasminogen Activators / Q000009:adverse effects* / Q000627:therapeutic use; D011994:Recombinant Proteins; D015912:Thrombolytic Therapy / Q000009:adverse effects*; D010959:Tissue Plasminogen Activator / Q000009:adverse effects* / Q000627:therapeutic use; D014463:Ultrasonography
chemical_list: D011994:Recombinant Proteins; D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator