title: Application of a Finnish mutagenicity model to drinking waters in the U.S.
abstract: Recent epidemiological studies conducted in Finland have reported a positive correlation between the mutagenicity of chlorinated drinking waters and certain human cancers. In these studies, past exposure to drinking water mutagenicity was assessed using a model developed by Vartiainen et al. [1] based on data collected in Finland. In this model, mutagenicity, as determined in the Ames assay, is a function of the total organic carbon (TOC) concentration of the water, chlorine dose, and to a minor extent, the concentration of ammonia. A study has been initiated to assess the applicability of this model to source waters and water treatment practices in the United States. Water samples were collected from three full-scale treatment plants and one pilot-scale plant. All the plants used chlorine exclusively for disinfection. One full-scale plant used ground water. Surface water sources were used by the other plants. TOC and ammonia concentrations were determined analytically and chlorine doses were obtained from the treatment plants. The water samples were concentrated by XAD resin adsorption for testing in the Ames assay. The observed levels of mutagenicity in the finished waters were 1.5 to 2-fold higher than those predicted using the model as specified in Vartiainen et al. [1]. Consequently, further validation is needed prior to widespread use of the Finnish model to assess exposure to mutagenicity in chlorinated drinking waters in the United States.
authors.affiliation: U.S. Environmental Protection Agency, Cincinnati, OH 45268, USA.
authors.forename: K M
authors.initials: KM
authors.lastname: Schenck
authors.forename: L J
authors.initials: LJ
authors.lastname: Wymer
authors.forename: B W
authors.initials: BW
authors.lastname: Lykins
authors.forename: R M
authors.initials: RM
authors.lastname: Clark
mesh_terms: D000641:Ammonia / Q000032:analysis; D002244:Carbon / Q000032:analysis; D002713:Chlorine / Q000009:adverse effects / Q000032:analysis*; D004784:Environmental Monitoring; D005387:Finland; D005618:Fresh Water / Q000032:analysis*; D006801:Humans; D008962:Models, Theoretical; D009152:Mutagenicity Tests; D009153:Mutagens / Q000032:analysis*; D009369:Neoplasms / Q000139:chemically induced; D012117:Resins, Synthetic / Q000737:chemistry; D014481:United States; D014874:Water Pollutants, Chemical / Q000009:adverse effects / Q000032:analysis*; D018508:Water Purification
chemical_list: D009153:Mutagens; D012117:Resins, Synthetic; D014874:Water Pollutants, Chemical; D002713:Chlorine; D002244:Carbon; D000641:Ammonia; C046797:amberlite