title: Clinical regeneration with guided tissue barriers.
abstract: This review of the current periodontal literature evaluates clinical regeneration with guided tissue barriers in infrabony defects and furcations. A meta-analysis was conducted by calculating weighted means with confidence intervals for each treatment group. Clinical improvement in infrabony defects was best for polylactic acid/polyglactin (PLA/PGA) barriers, with a mean pocket reduction of 5.3 mm and a mean gain in clinical probing attachment level of 4.7 mm. For furcations, special attention was given to the frequency of either complete or partial (> or = 50%) furcation closure. Complete furcation closure was an infrequent result of guided tissue regeneration, occurring in only 7% to 19% of furcations treated with barriers. For the time period reported, the best clinical results in furcations and infrabony defects occurred with PLA/PGA-type barriers. However, there were no statistically significant differences among the various barriers in infrabony defects or furcations.
authors.affiliation: Louisiana State University, School of Dentistry, New Orleans 70119, USA.
authors.forename: G H
authors.initials: GH
authors.lastname: Evans
authors.forename: R A
authors.initials: RA
authors.lastname: Yukna
authors.forename: K M
authors.initials: KM
authors.lastname: Cambre
authors.forename: D L
authors.initials: DL
authors.lastname: Gardiner
mesh_terms: D016301:Alveolar Bone Loss / Q000601:surgery*; D003094:Collagen; D017823:Furcation Defects / Q000601:surgery*; D016557:Guided Tissue Regeneration, Periodontal / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D019344:Lactic Acid; D007840:Latex; D008567:Membranes, Artificial; D011091:Polyesters; D011108:Polymers; D011138:Polytetrafluoroethylene
chemical_list: D007840:Latex; D008567:Membranes, Artificial; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D011138:Polytetrafluoroethylene; D003094:Collagen