title: Cytotoxic quassinoids from Simaba cedron.
abstract: Four new quassinoids, cedronolactones A-D (1-4), together with nine known compounds, simalikalactone D (5), chaparrinone (6), chaparrin (7), glaucarubolone (8), glaucarubol (9), samaderine Z (10), guanepolide (11), ailanquassin A (12), and polyandrol (13), were isolated from the wood of Simaba cedron. The chemical structures of 1-4 were elucidated on the basis of their chemical and spectral properties. Cedronolactone A (1) was shown to exhibit a significant in vitro cytotoxicity (IC50 0.0074 microg/mL) against P-388 cells.
authors.affiliation: Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-03, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Ozeki
authors.forename: Y
authors.initials: Y
authors.lastname: Hitotsuyanagi
authors.forename: E
authors.initials: E
authors.lastname: Hashimoto
authors.forename: H
authors.initials: H
authors.lastname: Itokawa
authors.forename: K
authors.initials: K
authors.lastname: Takeya
authors.forename: S
authors.initials: S
authors.lastname: de Mello Alves
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007783:Lactones / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured; D014934:Wood
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; D010936:Plant Extracts