Effect of cyclosporine on fertility in male rats.
The effect of cyclosporine (CsA) on fertility has assumed greater importance with the increasing numbers of pediatric transplantations being performed all over the world. Conflicting reports on the effects of CsA on sex hormones are available. This experimental animal study was designed to examine the effect of CsA on testicular weight, sperm counts, seminiferous tubular diameter (STD), testicular morphology, DNA flowcytometry, sex hormone levels, and fertility in male rats. Those rats who received CsA (20 mg/kg per day) showed significant reductions in testicular weight (P < 0.05), sperm count (P < 0.01), Johnsen score (P < 0.05), STD (P < 0.01), serum testosterone levels (P < 0.05), haploid cell population (P < 0. 001) in the testis, and fertility (P < 0.001) compared to those receiving CsA 10 mg/kg per day and control rats. These findings will have an important bearing for children receiving cyclosporine for long periods to guide the physician in optimally adjusting long-term treatment.
Srinivas
M
M
Department of Paediatric Surgery, All India Institute of Medical Sciences, New Delhi, India.
Agarwala
S
S
Datta Gupta
S
S
Das
S N
SN
Jha
P
P
Misro
M M
MM
Mitra
D K
DK
D000818:Animals; D000831:Animals, Newborn; D016572:Cyclosporine / Q000008:administration & dosage / Q000633:toxicity*; D004247:DNA / Q000032:analysis; D005298:Fertility / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D005434:Flow Cytometry; D005640:Follicle Stimulating Hormone / Q000097:blood; D005500:Follow-Up Studies; D006238:Haploidy; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000633:toxicity*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013076:Sperm Count / Q000187:drug effects; D013079:Sperm Maturation / Q000187:drug effects; D013094:Spermatozoa / Q000166:cytology / Q000187:drug effects; D013737:Testis / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D013739:Testosterone / Q000097:blood
D007166:Immunosuppressive Agents; D013739:Testosterone; D016572:Cyclosporine; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D004247:DNA