title: [Cavitating lung lesions in the course of ANCA-associated vasculitis: differential diagnostic aspects].
abstract: Antineutrophil cytoplasmatic antibodies (ANCA)-associated vasculitides (Wegener's granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome) show quite variable courses. Clinical features of the full blown generalized systemic vasculitis are usually found in the respiratory tract and the kidney. Pulmonary involvement of Wegener's granulomatosis shows commonly nodules and cavitations but also diffuse alveolar hemorrhage. We report the case of a 57 year-old man suffering from dyspnea, thoracal pain, arthralgia, purpura, scleritis and tinitus. Specimen of the kidney showed segmental glomerulosclerosis and tubulointerstitial nephritis. Because of the presence of cANCA Wegener's disease was assumed. Pulmonary infiltrates developed under immunosuppressive treatment with cyclophosphamid. As differential diagnosis of the pulmonary infiltrates, we considered invasive pulmonary aspergillosis as well as infiltrates due to Wegener's granulomatosis. In spite of maximal therapeutic management of patient died of respiratory and cardiovascular failure. The findings at autopsy showed distinct invasive pulmonary aspergillosis and perifocal hemorrhage.
authors.affiliation: Institut für Röntgendiagnostik, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main.
authors.forename: J
authors.initials: J
authors.lastname: Kirchner
authors.forename: H P
authors.initials: HP
authors.lastname: Raab
authors.forename: F
authors.initials: F
authors.lastname: Länger
authors.forename: R
authors.initials: R
authors.lastname: Wigand
authors.forename: P
authors.initials: P
authors.lastname: Mitrou
authors.forename: V
authors.initials: V
authors.lastname: Jacobi
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D001228:Aspergillosis / Q000000981:diagnostic imaging* / Q000473:pathology; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D014890:Granulomatosis with Polyangiitis / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008168:Lung / Q000473:pathology; D008172:Lung Diseases, Fungal / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D014657:Vasculitis / Q000000981:diagnostic imaging* / Q000473:pathology
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic
vernacular_title: Einschmelzende Lungenherde im Verlauf einer ANCA-assoziierten Vaskulitis: differentialdiagnostische Aspekte.