Evolution of the local calcium content around irradiated beta-tricalcium phosphate ceramic implants: in vivo study in the rabbit.
To evaluate whether dissolved calcium from tricalcium phosphate implants contributes to osseous wound healing in bone defects, the authors used nuclear radioactivated materials. Six months after irradiation, the calcium was still radioactive. Samples of the material were prepared and placed in rabbit condyles for 1, 3 and 9 months. Over time the condyles were retrieved and treated for histology or radiocounting. Measurements of the radioactivity of the slices and histomorphometry of the implants and surrounding tissues were performed. The authors observed that the radioactivity decreased regularly. Connective tissue had penetrated the pores and totally invaded the implants, first at the periphery of the implants, then inside the pores. Comparison of the results of radioactivity and histomorphometry suggest that part of the calcium from the implants was re-used specifically in the new osseous tissue.
Le Huec
J C
JC
Orthopédie A Le Rebeller CHU Pellegrin, INSERM U443, Université Victor Ségalen, Bordeaux, France.
Clément
D
D
Brouillaud
B
B
Barthe
N
N
Dupuy
B
B
Foliguet
B
B
Basse-Cathalinat
B
B
D000818:Animals; D001345:Autoradiography; D001672:Biocompatible Materials / Q000378:metabolism*; D001862:Bone Resorption; D018786:Bone Substitutes / Q000378:metabolism / Q000528:radiation effects*; D001842:Bone and Bones / Q000378:metabolism / Q000528:radiation effects*; D002118:Calcium / Q000032:analysis / Q000378:metabolism*; D002130:Calcium Phosphates / Q000378:metabolism*; D002132:Calcium Radioisotopes; D002516:Ceramics / Q000378:metabolism*; D005269:Femur / Q000378:metabolism / Q000528:radiation effects; D008297:Male; D011817:Rabbits; D014945:Wound Healing / Q000187:drug effects / Q000528:radiation effects
D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; D002132:Calcium Radioisotopes; C485817:beta-tricalcium phosphate; C018392:tricalcium phosphate; D002118:Calcium