Ultracytochemical analysis of E-PTA-positive synaptic junctions in postmortem-examined brains with neurologic disorders.
The synaptic junctions from four postmortem-examined brains were studied ultracytochemically, using the ethanolic phosphotungustic acid (E-PTA) method. A noteworthy finding was the presence of variable-shaped vesicles that were not observed in the control E-PTA-treated preparations. This structural change in synaptic junctions is thought to represent a degenerative process. It is suggested that the neuronal transmission in brains with acquired neuropathologic abnormalities may be impaired because of the degenerative change in synaptic junctions.
Tateno
A
A
Department of Pediatrics, Sakura Hospital, Toho University School of Medicine, Chiba, Japan.
Inomata
K
K
Makifuchi
T
T
D000328:Adult; D001344:Autopsy; D001921:Brain / Q000473:pathology / Q000648:ultrastructure; D004827:Epilepsy / Q000150:complications / Q000473:pathology*; D000431:Ethanol; D017629:Gap Junctions / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D008607:Intellectual Disability / Q000150:complications / Q000473:pathology*; D008854:Microscopy, Electron; D010772:Phosphotungstic Acid; D012997:Solvents; D013194:Staining and Labeling / Q000379:methods; D013569:Synapses / Q000473:pathology / Q000648:ultrastructure; D013572:Synaptic Vesicles / Q000473:pathology / Q000648:ultrastructure
D012997:Solvents; D010772:Phosphotungstic Acid; D000431:Ethanol