title: Trypanocidal effects of curcumin in vitro.
abstract: During the course of study searching for the antiparasitic agents from natural compounds, we found that curcumin showed cytotoxicity against African trypanosomes in vitro. The LD50 values of curcumin were 4.77 +/- 0.91 microM for bloodstream forms and 46.52 +/- 4.94 microM for procyclic forms of Trypanosoma brucei brucei (GUTat 3.1 clone).
authors.affiliation: Department of Pharmacognosy and Plant Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nose
authors.forename: T
authors.initials: T
authors.lastname: Koide
authors.forename: Y
authors.initials: Y
authors.lastname: Ogihara
authors.forename: Y
authors.initials: Y
authors.lastname: Yabu
authors.forename: N
authors.initials: N
authors.lastname: Ohta
mesh_terms: D000818:Animals; D003474:Curcumin / Q000494:pharmacology*; D051379:Mice; D014344:Trypanocidal Agents / Q000494:pharmacology*; D014346:Trypanosoma brucei brucei / Q000187:drug effects*
chemical_list: D014344:Trypanocidal Agents; D003474:Curcumin