[Cytomegalovirus and herpes simplex virus in pathogenesis and progression of native arteriosclerosis and recurrent stenosis after intervention].
An increasing number of clinical and experimental studies point to a contribution of various infectious organisms like chlamydia pneumoniae or herpesviruses to atherosclerosis in man. Cytomegalovirus induces atherosclerotic lesions in animals. In vitro studies reveal functional changes of endothelial cells after infection with cytomegalovirus. Infection with this virus renders endothelial cells immunogenic for cellular and humoral immune reactions. In man a significant association of infections with herpesviruses and atherosclerosis could be established in several studies. Cytomegalovirus infection has been incriminated as an independent risk factor in restenosis after coronary angioplasty.
Herzum
M
M
Abteilung Innere Medizin-Schwerpunkt Kardiologie, Universitätsklinik, Philipps-Universität Marburg.
Schaefer
J R
JR
Hufnagel
G
G
Maisch
B
B
D015906:Angioplasty, Balloon, Coronary; D000818:Animals; D001161:Arteriosclerosis / Q000473:pathology / Q000821:virology*; D003324:Coronary Artery Disease / Q000473:pathology / Q000821:virology*; D003587:Cytomegalovirus / Q000472:pathogenicity*; D003586:Cytomegalovirus Infections / Q000473:pathology / Q000821:virology*; D004730:Endothelium, Vascular / Q000473:pathology / Q000821:virology; D005260:Female; D006561:Herpes Simplex / Q000473:pathology / Q000821:virology*; D006801:Humans; D008297:Male; D012008:Recurrence; D012307:Risk Factors; D018139:Simplexvirus / Q000472:pathogenicity*; D014774:Virulence
Zytomegalie- und Herpes-simplex-Viren in Pathogenese und Progression der nativen Arteriosklerose und der Rezidivstenose nach Intervention.