title: Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study.
abstract: BACKGROUND
  The relationship of health risk behavior and disease in adulthood to the breadth of exposure to childhood emotional, physical, or sexual abuse, and household dysfunction during childhood has not previously been described.
  
  
  METHODS
  A questionnaire about adverse childhood experiences was mailed to 13,494 adults who had completed a standardized medical evaluation at a large HMO; 9,508 (70.5%) responded. Seven categories of adverse childhood experiences were studied: psychological, physical, or sexual abuse; violence against mother; or living with household members who were substance abusers, mentally ill or suicidal, or ever imprisoned. The number of categories of these adverse childhood experiences was then compared to measures of adult risk behavior, health status, and disease. Logistic regression was used to adjust for effects of demographic factors on the association between the cumulative number of categories of childhood exposures (range: 0-7) and risk factors for the leading causes of death in adult life.
  
  
  RESULTS
  More than half of respondents reported at least one, and one-fourth reported > or = 2 categories of childhood exposures. We found a graded relationship between the number of categories of childhood exposure and each of the adult health risk behaviors and diseases that were studied (P < .001). Persons who had experienced four or more categories of childhood exposure, compared to those who had experienced none, had 4- to 12-fold increased health risks for alcoholism, drug abuse, depression, and suicide attempt; a 2- to 4-fold increase in smoking, poor self-rated health, > or = 50 sexual intercourse partners, and sexually transmitted disease; and 1.4- to 1.6-fold increase in physical inactivity and severe obesity. The number of categories of adverse childhood exposures showed a graded relationship to the presence of adult diseases including ischemic heart disease, cancer, chronic lung disease, skeletal fractures, and liver disease. The seven categories of adverse childhood experiences were strongly interrelated and persons with multiple categories of childhood exposure were likely to have multiple health risk factors later in life.
  
  
  CONCLUSIONS
  We found a strong graded relationship between the breadth of exposure to abuse or household dysfunction during childhood and multiple risk factors for several of the leading causes of death in adults.
authors.affiliation: Department of Preventive Medicine, Southern California Permanente Medical Group (Kaiser Permanente), San Diego 92111, USA.
authors.forename: V J
authors.initials: VJ
authors.lastname: Felitti
authors.forename: R F
authors.initials: RF
authors.lastname: Anda
authors.forename: D
authors.initials: D
authors.lastname: Nordenberg
authors.forename: D F
authors.initials: DF
authors.lastname: Williamson
authors.forename: A M
authors.initials: AM
authors.lastname: Spitz
authors.forename: V
authors.initials: V
authors.lastname: Edwards
authors.forename: M P
authors.initials: MP
authors.lastname: Koss
authors.forename: J S
authors.initials: JS
authors.lastname: Marks
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002140:California / Q000453:epidemiology; D002423:Cause of Death; D002648:Child; D002649:Child Abuse / Q000706:statistics & numerical data; D016241:Child of Impaired Parents; D017579:Domestic Violence / Q000706:statistics & numerical data; D005190:Family; D005260:Female; D015438:Health Behavior; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012940:Social Problems; D011795:Surveys and Questionnaires; D014754:Violence / Q000706:statistics & numerical data