Molecular basis of beta-thalassemia in Thai Muslim patients in the the south of Thailand.
Among a sample of 29 unrelated Thai Muslim children, a total of 37 beta thalassemia genes was identified and 33 out of 37 mutations (89%) were characterized giving 6 different mutations. Four mutations [IVS-1 nt 5 (G-C), codon 19 (A-G), codons 41/42 (-CTTT) and IVS-1 nt 1 (G-T)] account for 86%. IVS-1 nt 5 (G-C) is the most common mutation found in Thai Muslim patients. Thai Muslim patients share the four most common mutations with Malays.
Laosombat
V
V
Department of Pediatrics, Faculty of Medicine, Prince of Songkhla University, Thailand. lvichai@ratree,psu,ac.th
Nopparatana
C
C
Wongchanchailert
M
M
Wiriyasateinkul
A
A
D002648:Child; D006801:Humans; D007514:Islam; D009154:Mutation; D013785:Thailand; D017086:beta-Thalassemia / Q000235:genetics*