title: A QTL with major effect on milk yield and composition maps to bovine chromosome 14.
abstract: A whole genome scan was undertaken in a granddaughter design comprising 1158 progeny-tested bulls in order to map QTL influencing milk yield and composition. In this paper we report the identification of a locus on the centromeric end of bovine Chromosome (Chr) 14, with major effect on fat and protein percentage as well as milk yield. The genuine nature of this QTL was verified using the grand2-daughter design, that is, by tracing the segregating QTL alleles from heterozygous grandsires to their maternal grandsons and confirming the predicted QTL allele substitution effect.
authors.affiliation: Department of Genetics, Faculty of Veterinary Medicine, University of Liège, Belgium.
authors.forename: W
authors.initials: W
authors.lastname: Coppieters
authors.forename: J
authors.initials: J
authors.lastname: Riquet
authors.forename: J J
authors.initials: JJ
authors.lastname: Arranz
authors.forename: P
authors.initials: P
authors.lastname: Berzi
authors.forename: N
authors.initials: N
authors.lastname: Cambisano
authors.forename: B
authors.initials: B
authors.lastname: Grisart
authors.forename: L
authors.initials: L
authors.lastname: Karim
authors.forename: F
authors.initials: F
authors.lastname: Marcq
authors.forename: L
authors.initials: L
authors.lastname: Moreau
authors.forename: C
authors.initials: C
authors.lastname: Nezer
authors.forename: P
authors.initials: P
authors.lastname: Simon
authors.forename: P
authors.initials: P
authors.lastname: Vanmanshoven
authors.forename: D
authors.initials: D
authors.lastname: Wagenaar
authors.forename: M
authors.initials: M
authors.lastname: Georges
mesh_terms: D000483:Alleles; D000818:Animals; D002417:Cattle / Q000235:genetics* / Q000502:physiology; D002503:Centromere; D002874:Chromosome Mapping; D005260:Female; D008297:Male; D008892:Milk / Q000737:chemistry; D019655:Quantitative Trait, Heritable