A new class of cis-monobactam derivatives bearing a sulfamoyloxymethyl or an N-alkylsulfamoyloxymethyl group at position 4: synthesis and antibacterial activity.
A new series of monobactam derivatives, bearing unsubstituted or N-monosubstituted sulfamoyloxymethyl groups in position 4 was synthesized either in racemic or in optically active form. Their in vitro antibacterial activity was tested in comparison with carumonam 1a and its methoxyimino derivative 1b.
Guanti
G
G
Dipartimento di Chimica e Chimica Industriale e C.N.R., Centro di Studi per la Chimica dei Composti Cicloalifatici ed Aromatici, Genoa, Italy. guanti@chimica unige.it
Riva
R
R
Cascio
G
G
Manghisi
E
E
Morandotti
G
G
Satta
G
G
Sperning
R
R
D004926:Escherichia coli / Q000187:drug effects; D015394:Molecular Structure; D008997:Monobactams / Q000138:chemical synthesis* / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013457:Sulfur Compounds / Q000138:chemical synthesis / Q000494:pharmacology
D008997:Monobactams; D013457:Sulfur Compounds