[Cross susceptibility of ototoxicity about aminoglycoside antibiotics].
A familial investigation was made in three families with deafness patients caused by aminoglycoside (AMI). The results showed that there was cross susceptibility among a few AMI antibiotics. The people with familial history of deafness caused by AMI were easier to be toxic than those without familial history, even though little dose of AMI for the former, especially for children. The cross susceptibility is dominated by inheritance of matriarchal heredity and by general chromosome. The data suggest that medical history should be inquired before treatment with AMI, and patients with matriarchal heredity must be prohibited from using AMI.
Wu
J
J
Military General Hospital, Jinan.
D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003638:Deafness / Q000139:chemically induced / Q000235:genetics*; D004198:Disease Susceptibility; D005192:Family Health; D005260:Female; D005839:Gentamicins / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007612:Kanamycin / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D010375:Pedigree
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D007612:Kanamycin