Water vapor sorption by peptides, proteins and their formulations.
The interactions of pharmaceutical peptides, proteins and their formulations with environmental water vapor are reviewed. Particular attention is paid to the importance of the physical structure and chemical diversity of peptides and proteins, and comparisons are made with the mechanisms of water vapor sorption by synthetic macromolecular systems. The influences of formulation processes and additives are also considered and suggestions made for future areas of research.
Shamblin
S L
SL
University of Wisconsin-Madison, School of Pharmacy 53706, USA.
Hancock
B C
BC
Zografi
G
G
D000327:Adsorption; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D010455:Peptides / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
D010455:Peptides; D011506:Proteins; D014867:Water