Interleukin-17.
The particular interest of IL-17, a homodimeric cytokine of about 32 kDa, is the strict requirement for an activation signal to induce its expression from a rather restricted set of cells, human memory T cells or mouse alpha beta TCR+CD4-CD8- thymocytes. In contrast with the tightly controlled expression pattern of this gene, the IL-17 receptor, a novel cytokine receptor, is ubiquitously distributed but apparently more abundant in spleen and kidney. In addition to its capture by the T lymphotropic Herpesvirus Saimiri (HVS), this cytokine is inducing the secretion of IL-6, IL-8, PGE2, MCP-1 and G-CSF by adherent cells like fibroblasts, keratinocytes, epithelial and endothelial cells. IL-17 is also able to induce ICAM-1 surface expression, proliferation of T cells, and growth and differentiation of CD34+ human progenitors into neutrophils when cocultured in presence of irradiated fibroblasts. In vitro, IL-17 synergizes with other proinflammatory signals like TNF alpha for GM-CSF induction, and with CD40-ligand for IL-6, IL-8, RANTES and MCP-1 secretion from kidney epithelial cells. In vivo, injection of IL-17 induces a neutrophilia, except in IL-6-KO mice. The involvement of IL-17 in rejection of kidney graft has also been demonstrated. The role of this T cell secreted factor in various inflammatory processes is presently investigated.
Fossiez
F
F
Schering-Plough, Laboratory for Immunological Research, Dardilly, France.
Banchereau
J
J
Murray
R
R
Van Kooten
C
C
Garrone
P
P
Lebecque
S
S
D000818:Animals; D016207:Cytokines / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D020381:Interleukin-17; D007378:Interleukins / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D012333:RNA, Messenger; D018123:Receptors, Interleukin / Q000235:genetics; D053722:Receptors, Interleukin-17; D011994:Recombinant Proteins / Q000235:genetics
D016207:Cytokines; C109985:IL17RA protein, human; C491673:Il17ra protein, mouse; D020381:Interleukin-17; D007378:Interleukins; D012333:RNA, Messenger; D018123:Receptors, Interleukin; D053722:Receptors, Interleukin-17; D011994:Recombinant Proteins