The retinoblastoma gene family: cousins with overlapping interests.
The retinoblastoma tumor suppressor gene (RB1) and its relatives, p107 and p130, encode a family of proteins that share several properties, including the capacity to regulate E2F-dependent transcription and inhibit cell-cycle progression. Although RB1 inactivation is widely implicated in human cancer, the growth regulatory functions of p107 and p130, and the functional relationships within the gene family, are emerging only recently. Here we review studies of RB1 gene family function, with emphasis on in vivo experiments that explore shared and distinct functions within this family.
Mulligan
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Center for Cancer Research, Howard Hughes Medical Institute, Cambridge, MA, USA.
Jacks
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D000818:Animals; D016147:Genes, Tumor Suppressor; D006131:Growth Inhibitors / Q000235:genetics; D006801:Humans; D051379:Mice; D008817:Mice, Mutant Strains; D009687:Nuclear Proteins / Q000235:genetics; D010750:Phosphoproteins / Q000235:genetics; D011506:Proteins; D016160:Retinoblastoma Protein / Q000235:genetics*; D050720:Retinoblastoma-Like Protein p107; D050717:Retinoblastoma-Like Protein p130
D006131:Growth Inhibitors; D009687:Nuclear Proteins; D010750:Phosphoproteins; D011506:Proteins; C493844:RBL1 protein, human; C493837:RBL2 protein, human; C489485:Rbl1 protein, mouse; C493838:Rbl2 protein, mouse; D016160:Retinoblastoma Protein; D050720:Retinoblastoma-Like Protein p107; D050717:Retinoblastoma-Like Protein p130