[Immunobiological properties of phospholipid antigens of Rickettsia prowazekii incorporated into rickettsial liposomal preparations].
In this article materials on obtaining rickettsial liposomal preparations on the basis of R.prowazekii phospholipid antigen and chemical typhus vaccine are presented. Electron microscopic studies revealed the formation of liposomes in this system. Liposomal preparations were not hemotoxic and produced no toxic action in experiments on guinea pigs and white mice. Phospholipid antigens incorporated into liposomal preparations were found to produce a potentiating effect on the immunogenic properties of chemical typhus vaccine. The adjuvant properties of rickettsial phospholipids incorporated into liposomes on the basis chemical typhus vaccine were registered.
Timasheva
O A
OA
Gamaleya Research Institute of Epidemiology and Microbiology, Moscow, Russia.
Petrov
V F
VF
Tarasevich
I V
IV
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D000942:Antigens, Bacterial / Q000302:isolation & purification*; D001428:Bacterial Vaccines / Q000276:immunology; D006168:Guinea Pigs; D007111:Immunity, Cellular; D008081:Liposomes; D051379:Mice; D008854:Microscopy, Electron; D010743:Phospholipids / Q000276:immunology*; D011817:Rabbits; D012283:Rickettsia prowazekii / Q000276:immunology*
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D008081:Liposomes; D010743:Phospholipids
Izuchenie immunobiologicheskikh svoĭstv fosfolipidnykh antigenov Rickettsia prowazekii v sostave rickettsial liposomal preparations.