title: [Effect of human recombinant gamma-interferon on proliferative activity of human laryngeal cancer cell lines].
abstract: The effect of human on PCNA expressions of HEP-2 lines was investigated using LSAB (Labelled streptacidin biotin method) with monoclonal antibody Ki-67 (anti-PCNA). The results showed that the PCNA expression which reflects the proliferative activity of cells was dependent on dose of rhu-IFN-gamma in HEP-2 cell lines. Thus, our data suggest that rhu-IFN-gamma might be useful in the treatment of laryngeal cancer because it provides effective cytostatic.
authors.affiliation: Department of Otolaryngology, Tongji Hospital, Tongji Medical University, Wuhan.
authors.forename: Q
authors.initials: Q
authors.lastname: Ruan
authors.forename: Q
authors.initials: Q
authors.lastname: Liu
authors.forename: S
authors.initials: S
authors.lastname: Tan
mesh_terms: D004305:Dose-Response Relationship, Drug; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology*; D007822:Laryngeal Neoplasms / Q000378:metabolism / Q000473:pathology*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism*; D011994:Recombinant Proteins; D014407:Tumor Cells, Cultured
chemical_list: D018809:Proliferating Cell Nuclear Antigen; D011994:Recombinant Proteins; D007371:Interferon-gamma