title: Hepatic glycogen and lactate handling in dietary obese rats.
abstract: Hepatic balances for glucose and its precursor, lactate, were calculated by measuring hepatic blood flows and the arteriovenous differences of these metabolites in 2 groups of overweight rats: cafeteria diet-fed rats and post-cafeteria rats. Obese rats show abnormal hepatic glycogen handling, since they do not mobilize all hepatic glycogen stores after 24-hour starvation, in a situation in which a lower rate of hepatic glucose output and a higher capacity for lactate uptake are attained. The important decrease (about 50%) in the hepatic blood flows observed in post-cafeteria rats versus control rats was similar to that caused by 24-hour starvation in control animals, suggesting that after withdrawal of the cafeteria diet, the liver blood flow of the post-cafeteria rats was adapted to the low-food intake in order to make better use of the energy consumed. The results also suggest an increased efficiency of hepatic lactate uptake in post-cafeteria rats.
authors.affiliation: Department de Biologia Fonamental i Ciències de la Salut, Universitat de les Illes Balears, Palma de Mallorca, España.
authors.forename: I
authors.initials: I
authors.lastname: Lladó
authors.forename: A
authors.initials: A
authors.lastname: Palou
authors.forename: A
authors.initials: A
authors.lastname: Pons
mesh_terms: D000818:Animals; D004032:Diet; D005260:Female; D005947:Glucose / Q000378:metabolism; D019344:Lactic Acid / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008102:Liver Circulation / Q000502:physiology; D008112:Liver Glycogen / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism*; D009929:Organ Size / Q000502:physiology; D011168:Portal System / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D008112:Liver Glycogen; D019344:Lactic Acid; D005947:Glucose