title: Clinical and biochemical determinants of plasma lipid peroxide levels in type 2 diabetes.
abstract: The enhanced risk and increased severity of atheroma in diabetes is well recognized but, as yet, incompletely explained. A cross-sectional study of vascular disease risk factors in a group of type 2 diabetic patients from South West Scotland has revealed an association between glycaemic control, assessed by HbAl level and plasma lipid peroxides measured by a specific high-performance liquid chromatography method. Duration of diabetes appeared to be a subsidiary contributor to lipid peroxidation. We suggest this evidence supports the importance of glycaemic control in modulating glyco-oxidative mechanisms probably crucial to production of diabetic complications. Atherosclerosis prevention in diabetes may hinge on exemplary simultaneous control of both hyperglycaemia and hyperlipidaemia.
authors.affiliation: Department of Medicine, Dumfries & Galloway Royal Infirmary.
authors.forename: J R
authors.initials: JR
authors.lastname: Lawrence
authors.forename: G R
authors.initials: GR
authors.lastname: Campbell
authors.forename: H
authors.initials: H
authors.lastname: Barrington
authors.forename: E A
authors.initials: EA
authors.lastname: Malcolm
authors.forename: G
authors.initials: G
authors.lastname: Brennan
authors.forename: D H
authors.initials: DH
authors.lastname: Wiles
authors.forename: J R
authors.initials: JR
authors.lastname: Paterson
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008054:Lipid Peroxides / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012907:Smoking / Q000097:blood
chemical_list: D007004:Hypoglycemic Agents; D008054:Lipid Peroxides