In vitro study of BCX-34: a new human T-lymphocyte-specific purine phosphorylase inhibitor.
Iwata
H
H
Department of Urology, Metic Transplantation Laboratories, University of Southern California School of Medicine, Los Angeles 90057, USA.
Wada
Y
Y
Walsh
M
M
Montgomery
J A
JA
Hirose
H
H
Mendez
R
R
Cicciarelli
J
J
Iwaki
Y
Y
D000818:Animals; D002461:Cell Line, Transformed; D003849:Deoxyguanosine / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006147:Guanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007376:Interleukin-2 / Q000096:biosynthesis; D019169:Jurkat Cells; D007700:Kinetics; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008810:Mice, Inbred C57BL; D011683:Purine-Nucleoside Phosphorylase / Q000037:antagonists & inhibitors*; D051381:Rats; D011916:Rats, Inbred F344; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000201:enzymology / Q000276:immunology*
D004791:Enzyme Inhibitors; D007166:Immunosuppressive Agents; D007376:Interleukin-2; D006147:Guanine; C104194:peldesine; D011683:Purine-Nucleoside Phosphorylase; D003849:Deoxyguanosine