title: Macrocyclic diterpenoids from Euphorbia semiperfoliata.
abstract: In addition to known compounds, the aerial parts of E. semiperfoliata afforded an abietanolide (3), 13 jatrophane polyesters (4-9, 12, 14-19), two 4-deoxyphorbol diesters (23, 24), and a pair of epimeric diterpenes (21, 22) with a novel carbon skeleton, which was named euphoperfoliane. Structures were determined by spectroscopic analysis, and the main conformational features of jatropha-6(17),11-dienes are discussed in detail. The obtained isolation yield of several jatrophanes was unprecedented within the spurges (Euphorbia spp.), making E. semiperfoliata a unique source of macrocyclic diterpenoids.
authors.affiliation: Dipartimento di Scienza e Tecnologia del Farmaco, via Giuria 9, 10125 Torino, Italy. appendin@pharm.unito.it
authors.forename: G
authors.initials: G
authors.lastname: Appendino
authors.forename: S
authors.initials: S
authors.lastname: Jakupovic
authors.forename: G C
authors.initials: GC
authors.lastname: Tron
authors.forename: J
authors.initials: J
authors.lastname: Jakupovic
authors.forename: V
authors.initials: V
authors.lastname: Milon
authors.forename: M
authors.initials: M
authors.lastname: Ballero
mesh_terms: D002240:Carbohydrate Sequence; D004224:Diterpenes / Q000302:isolation & purification*; D019665:Euphorbiaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D004224:Diterpenes