[Does flumazenil correct disorders of intracardiac conduction induced by accidental intravenous injection of bupivacaine?].
The authors report the case of a patient who experienced intracardiac conduction disturbances from accidental intravenous injection of bupivacaine, which were reversed by an intravenous injection of flumazenil. Flumazenil could act either in displacing bupivacaine from its binding site, or by an interaction involving the GABAergic system, unless a specific interaction between flumazenil and bupivacaine does exist. In case of experimental confirmation of this feature, flumazenil could be proposed as a new therapeutic tool for bupivacaine-induced cardiotoxicity.
Lenfant
F
F
Département d'anesthésie-réanimation, hôpital général, Dijon, France.
Volot
F
F
Freysz
M
M
Wilkening
M
M
D000779:Anesthetics, Local / Q000008:administration & dosage / Q000009:adverse effects*; D000931:Antidotes / Q000494:pharmacology / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced* / Q000188:drug therapy; D002045:Bupivacaine / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005442:Flumazenil / Q000494:pharmacology / Q000627:therapeutic use*; D006329:Heart Conduction System / Q000187:drug effects*; D006801:Humans; D007049:Iatrogenic Disease; D007275:Injections, Intravenous; D008875:Middle Aged
D000779:Anesthetics, Local; D000931:Antidotes; D005442:Flumazenil; D002045:Bupivacaine
Le flumazénil corrige-t-il les troubles de la conduction intracardiaque induits par l'injection intraveineuse accidentelle de bupivacaïne?