Taste conditioning effects of buprenorphine in morphine-naive and morphine-experienced rats.
Male Sprague-Dawley rats were injected daily with saline (morphine-naive rats) or 20 mg kg-1 morphine (morphine-experienced rats), starting 15 days before the experiment. Subsequent taste conditioning indicated that 0.1 mg kg-1 buprenorphine significantly decreased 0.025% saccharin consumption in morphine-naive, but not in morphine-experienced rats. A 10 mg kg-1 dose of morphine gave similar results, while d-amphetamine (0.75 mg kg-1) was consistently aversive. It was concluded that morphine experience selectively blocks the aversive effects of buprenorphine in rats; thus it possibly increases the potential for buprenorphine abuse.
Gaiardi
M
M
Department of Pharmacology, University of Bologna, Italy.
Gubellini
C
C
Bartoletti
M
M
D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology; D002047:Buprenorphine / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects*; D003913:Dextroamphetamine / Q000494:pharmacology; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012439:Saccharin; D013549:Sweetening Agents; D013649:Taste / Q000187:drug effects*
D000701:Analgesics, Opioid; D001067:Appetite Depressants; D013549:Sweetening Agents; D002047:Buprenorphine; D009020:Morphine; D012439:Saccharin; D003913:Dextroamphetamine