Alternative splicing and structure of the human erythroid dematin gene.
Human erythroid dematin is a cytoskeletal protein capable of bundling actin filaments in vitro. The carboxyl terminal domain of dematin is homologous to the headpiece domain of villin, an actin-binding protein of the brush border cytoskeleton. Here we report the complete structure of the dematin gene located on human chromosome 8p21.1, a region frequently deleted in prostate cancer. The dematin gene is composed of 15 exons spanning approximately 15 kb. We also report two novel isoforms of dematin derived from alternative splicing of the dematin gene in the brain.
Kim
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Laboratory of Tumor Cell Biology, St. Elizabeth's Medical Center, Tufts University School of Medicine, ACH4, 736 Cambridge Street, Boston, MA 02135, USA.
Azim
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Chishti
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AH
D017398:Alternative Splicing; D000595:Amino Acid Sequence; D001483:Base Sequence; D001798:Blood Proteins / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8; D018076:DNA, Complementary; D015672:Erythroid Precursor Cells / Q000378:metabolism; D006801:Humans; D008840:Microfilament Proteins; D008969:Molecular Sequence Data; D010750:Phosphoproteins; D017386:Sequence Homology, Amino Acid
D001798:Blood Proteins; C044805:DMTN protein, human; D018076:DNA, Complementary; D008840:Microfilament Proteins; D010750:Phosphoproteins