title: Synthesis of 1-methyl-4-(N-aroyl)-piperidinamides with anti-inflammatory and analgesic activities.
abstract: Two series of 1-methyl-4-(N-aroyl)-piperidinamides were synthesized and evaluated for their anti-inflammatory and analgesic properties, as well as for their gastrointestinal irritation liability. A non-aromatic derivative, 1-methyl-4-(N-cyclohexanoyl)-piperidinamide, was synthesized and evaluated in order to obtain a more exhaustive knowledge of the structure-activity relationship.
authors.affiliation: Istituto di Analitica Farmaceutica, Facoltà di Farmacia, Università di Sassari, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Pau
authors.forename: G
authors.initials: G
authors.lastname: Boatto
authors.forename: R
authors.initials: R
authors.lastname: Cerri
authors.forename: F
authors.initials: F
authors.lastname: Palagiano
authors.forename: W
authors.initials: W
authors.lastname: Filippelli
authors.forename: G
authors.initials: G
authors.lastname: Falcone
authors.forename: E
authors.initials: E
authors.lastname: Lampa
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology; D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D004487:Edema / Q000188:drug therapy; D005260:Female; D008297:Male; D051379:Mice; D015394:Molecular Structure; D010880:Piperidines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
chemical_list: D000577:Amides; D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010880:Piperidines