Multiple schwannomas, multiple nevi, and multiple vaginal leiomyomas: a new dominant syndrome.
We report on a family of seven affected with a new syndrome of multiple deep schwannomas, multiple nevi (both intradermal and compound types), and multiple leiomyomas of the vagina. Inheritance is dominant, whether autosomal or X-linked cannot be determined at this time. The nevi, which are congenital, appear to be a marker for the syndrome. Both the schwannomas and leiomyomas do not manifest until adulthood.
Gorlin
R J
RJ
Department of Oral Science, University of Minnesota School of Dentistry, Minneapolis 55455, USA. gorli002@maroon.tc.umn.edu
Koutlas
I G
IG
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000235:genetics*; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics*; D009442:Neurilemmoma / Q000235:genetics* / Q000473:pathology; D009506:Nevus / Q000235:genetics*; D010375:Pedigree; D012878:Skin Neoplasms / Q000235:genetics*; D014625:Vaginal Neoplasms / Q000235:genetics*