Design and development strategy for the rotary blood pump.
Development of an antitraumatic antithrombogenic and durable blood pump is a very difficult task. Based upon this author's experience of over 35 years in the development of various types of cardiac prostheses, development strategies for a rotary blood pump are described. A step-by-step development strategy is thus proposed. Initially, the development of a 2 day antitraumatic pump (Phase 1) would be made. Then, conversion of this pump to a 2 week antithrombogenic pump (Phase 2) should be attempted. After the successful development of the Phase 2 pump, the conversion of this device to a durable, implantable, and long-term blood pump (Phase 3) should be established. Based upon this development strategy, 2 rotary blood pumps, namely, the axial flow blood pump and the centrifugal blood pump, have been developed in less than 6 years with modest development costs.
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Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA.
D000222:Adaptation, Physiological; D001243:Assisted Circulation / Q000295:instrumentation; D001672:Biocompatible Materials / Q000737:chemistry; D001794:Blood Pressure; D001798:Blood Proteins / Q000737:chemistry; D002315:Cardiopulmonary Bypass / Q000295:instrumentation; D003365:Costs and Cost Analysis; D015199:Extracorporeal Membrane Oxygenation / Q000295:instrumentation; D006354:Heart, Artificial / Q000145:classification / Q000191:economics; D006353:Heart-Assist Devices; D006461:Hemolysis; D018056:Hemorheology; D006358:Hot Temperature; D006801:Humans; D011474:Prosthesis Design / Q000145:classification / Q000191:economics; D012399:Rotation; D013499:Surface Properties; D013927:Thrombosis / Q000517:prevention & control; D014025:Titanium
D001672:Biocompatible Materials; D001798:Blood Proteins; D014025:Titanium