title: Transforming growth factor-beta in renal disease.
abstract: An extensive number of animal and clinical studies indicate that transforming growth factor-beta (TGF-beta s) play an important role in inflammatory and fibrotic diseases, including renal fibrosis. Recent mouse models harboring genetically engineered alterations in TGF-beta pathways reveal complicated mechanisms of regulation of TGF-beta activity in vivo. The purpose of this review is to present recent advances relevant to our understanding of the TGF-beta-signaling system in renal physiology and pathophysiology.
authors.affiliation: Medizinische Klinik IV mit Poliklinik, Friedrich-Alexander Universität Erlangen-Nürnberg, Germany. Markus.Bitzer@rzmail.uni-erlangen.de
authors.forename: M
authors.initials: M
authors.lastname: Bitzer
authors.forename: R B
authors.initials: RB
authors.lastname: Sterzel
authors.forename: E P
authors.initials: EP
authors.lastname: Böttinger
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005355:Fibrosis / Q000378:metabolism; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism*
chemical_list: D018125:Receptors, Transforming Growth Factor beta; D016212:Transforming Growth Factor beta