title: Lithium discontinuation and subsequent effectiveness.
abstract: OBJECTIVE
  Several reports have raised concern that the discontinuation of lithium may result in treatment resistance following recurrence of affective disorder. This report explores this possibility.
  
  
  METHODS
  The data derive from a large, naturalistic follow-up of patients with major depressive disorder or mania. Twenty-eight of the patients in the study were free of lithium and experiencing an episode of mania or schizoaffective mania diagnosed according to Research Diagnostic Criteria when they entered the study, recovered while taking lithium, later experienced a recurrence while not taking lithium, and then resumed lithium treatment. Survival analyses of time to recovery and, subsequently, time to recurrence, used continued lithium treatment as an additional censoring variable.
  
  
  RESULTS
  Patients given lithium recovered no more quickly from their index episode than they did from their first prospectively observed episode. Moreover, lithium prophylaxis appeared no less effective after the first prospectively observed episode than after the index episode.
  
  
  CONCLUSIONS
  These findings provide no evidence that lithium discontinuation results in treatment resistance when lithium is resumed.
authors.affiliation: University of Iowa College of Medicine, Iowa City 52242-1000, USA. william-coryell@uiowa.edu
authors.forename: W
authors.initials: W
authors.lastname: Coryell
authors.forename: D
authors.initials: D
authors.lastname: Solomon
authors.forename: A C
authors.initials: AC
authors.lastname: Leon
authors.forename: H S
authors.initials: HS
authors.lastname: Akiskal
authors.forename: M B
authors.initials: MB
authors.lastname: Keller
authors.forename: W A
authors.initials: WA
authors.lastname: Scheftner
authors.forename: T
authors.initials: T
authors.lastname: Mueller
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000517:prevention & control; D004334:Drug Administration Schedule; D004351:Drug Resistance; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015993:Life Tables; D008094:Lithium / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D011446:Prospective Studies; D011618:Psychotic Disorders / Q000188:drug therapy* / Q000517:prevention & control; D012008:Recurrence; D012307:Risk Factors; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D008094:Lithium