Detection of phosphomonoester signals in proton-decoupled 31P NMR spectra of the myocardium of patients with myocardial hypertrophy.
Proton-decoupled 31P NMR spectroscopy at 1.5 T of the anterior left ventricular myocardium was used to monitor myocardial phosphate metabolism in asymptomatic patients with hypertrophic cardiomyopathy (HCM, n = 14) and aortic stenosis (AS, n = 12). In addition to the well-known phosphorus signals a phosphomonoester (PME) signal was detected at about 6.9 ppm in 7 HCM and 2 AS patients. This signal was not observed in the spectra of normal controls (n = 11). We suggest that in spectra of patients with myocardial hypertrophy the presence of a PME signal reflects alterations in myocardial glucose metabolism.
Jung
W I
WI
Physikalisches Institut, University of Tübingen, Tübingen, 72076, Germany.
Sieverding
L
L
Breuer
J
J
Schmidt
O
O
Widmaier
S
S
Bunse
M
M
van Erckelens
F
F
Apitz
J
J
Dietze
G J
GJ
Lutz
O
O
D019794:2,3-Diphosphoglycerate / Q000032:analysis; D000255:Adenosine Triphosphate / Q000032:analysis; D000293:Adolescent; D000328:Adult; D001024:Aortic Valve Stenosis / Q000378:metabolism; D002312:Cardiomyopathy, Hypertrophic / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000378:metabolism; D006352:Heart Ventricles / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D009206:Myocardium / Q000737:chemistry* / Q000378:metabolism; D009243:NAD / Q000032:analysis; D010755:Organophosphates / Q000032:analysis*; D010710:Phosphates / Q000378:metabolism; D010725:Phosphocreatine / Q000032:analysis; D010758:Phosphorus
D010755:Organophosphates; D010710:Phosphates; D010725:Phosphocreatine; D009243:NAD; D019794:2,3-Diphosphoglycerate; D010758:Phosphorus; D000255:Adenosine Triphosphate; D005947:Glucose