Comparison between the effects of D-mannoheptulose and its hexaacetate ester upon D-glucose metabolism in rat erythrocytes.
At a 2.0 mM concentration, D-mannoheptulose hexaacetate, but not unesterified D-mannoheptulose, inhibited the generation of radioactive acidic metabolites by rat erythrocytes exposed to D-[U-14C]glucose (8.3 mM). It is proposed that D-mannoheptulose hexaacetate represents a valuable tool to interfere with the phosphorylation of D-glucose in cell types otherwise resistant to the heptose.
Ladrière
L
L
Laboratory of Experimental Medicine, Brussels Free University, Belgium.
Kadiata
M M
MM
Malaisse
W J
WJ
D000085:Acetates / Q000494:pharmacology*; D000818:Animals; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D004952:Esters / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism*; D019344:Lactic Acid / Q000378:metabolism; D008356:Mannoheptulose / Q000031:analogs & derivatives / Q000494:pharmacology*; D051381:Rats
D000085:Acetates; D004952:Esters; D019344:Lactic Acid; D008356:Mannoheptulose; D005947:Glucose