Spectrofluorometric determination of piroxicam.
The spectrofluorometric determination of piroxicam [4-hydroxy-2-methyl-N-(2-pyridyl)-2II-1,2-benzothiazine-3-carboxam ide-1, 1-dioxide] in pharmaceutical tablets is described. It involves excitation at 330 nm of an acid solution (HNO3 0.5 M) of the drug, and measurement of the fluorescence intensity at 440 nm. The linear range is 0.01-1.25 micrograms ml-1.
Damiani
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PC
Departamento de Química Analítica, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Argentina.
Bearzotti
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M
Cabezón
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M
Olivieri
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AC
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis*; D002214:Capsules; D006863:Hydrogen-Ion Concentration; D017942:Nitric Acid; D010894:Piroxicam / Q000032:analysis*; D015203:Reproducibility of Results; D012972:Sodium Hydroxide; D013050:Spectrometry, Fluorescence / Q000379:methods
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002214:Capsules; D010894:Piroxicam; D017942:Nitric Acid; D012972:Sodium Hydroxide