[Metastatic potential correlates with cell surface carbohydrate profiles of nasopharyngeal carcinoma].
In order to investigate the changes in glycoprotein structure between non-metastatic and metastatic cells of nasopharyngerl carcinoma (NPC), peanut agglutinin (PNA), ulex europeaus (UEA-I) and concanavalin ensifomis agglutinin (ConA) staining were used to examine 102 nasopharyngeal carcinoma tissues (84 primary tumors and 18 metastatic lymph nodes) with the avidin-biotinperoxidase complex method. PNA reaction was positive in most cells of nasopharyngeal carcinomas regardles of in histopathologic type, the degree of differentiation and metastasis. The levels of UEA-I receptors apparently increased during nasopharyngeal carcinoma progression from non-metastatic to metastatic tumors. The binding to ConA clearly decreased in the cells of metastatic cases and metastatic lymph node. So, the increased expression of UEA-I receptors and decrease of ConA receptors on tumor cells might have been implicated in the expression of metastatic potential.
Huang
H
H
Changhai Hospital, Second Military University.
Jiang
D
D
Li
Z
Z
D010367:Arachis; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000556:secondary; D006801:Humans; D008207:Lymphatic Metastasis; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D011956:Receptors, Cell Surface; D011952:Receptors, Concanavalin A / Q000378:metabolism*; D011975:Receptors, Mitogen / Q000378:metabolism*
D011956:Receptors, Cell Surface; D011952:Receptors, Concanavalin A; D011975:Receptors, Mitogen; C053203:Ulex europaeus lectin receptor; C038223:peanut agglutinin receptor