title: A randomized controlled trial comparing nonoxynol-9 lubricated condoms with silicone lubricated condoms for prophylaxis.
abstract: OBJECTIVE
  We tested the effect of nonoxynol-9 (N-9) in condom lubrication on the risk of acquiring STD and genital discomfort.
  
  
  METHODS
  The study was a triple masked, randomised controlled trial comparing N-9 lubricated condoms with plain silicone lubricated condoms among Dominican female sex workers.
  
  
  RESULTS
  Randomisation provided two groups (313 for N-9 and 322 for plain) similar in baseline characteristics, but extensive loss to follow up occurred (56 women in each group completed the 24 week follow up). Most vaginal acts with clients were protected with condoms (99% of vaginal sex) but fewer acts with non-clients were protected (43% of vaginal sex). No significant differences occurred in rates of cervical infections (N-9 = 3.4 per 100 person months v plain = 2.8), trichomoniasis (N-9 = 2.8 v plain = 3.6), or discomfort rates (N-9 = 0.82 v plain = 0.92).
  
  
  CONCLUSIONS
  Plain silicone lubricated condoms are as effective as N-9 lubricated condoms, cost less, have longer expected shelf life, and therefore may be the better condom to provide.
authors.affiliation: Family Health International, Durham, North Carolina, USA.
authors.forename: R E
authors.initials: RE
authors.lastname: Roddy
authors.forename: M
authors.initials: M
authors.lastname: Cordero
authors.forename: K A
authors.initials: KA
authors.lastname: Ryan
authors.forename: J
authors.initials: J
authors.lastname: Figueroa
mesh_terms: D000293:Adolescent; D000328:Adult; D002690:Chlamydia Infections / Q000517:prevention & control; D017280:Condoms; D005260:Female; D006069:Gonorrhea / Q000517:prevention & control; D006801:Humans; D008153:Lubrication; D008875:Middle Aged; D017137:Nonoxynol; D010146:Pain / Q000517:prevention & control*; D011477:Sex Work; D012749:Sexually Transmitted Diseases / Q000517:prevention & control*; D012828:Silicones; D014247:Trichomonas Vaginitis / Q000517:prevention & control
chemical_list: D012828:Silicones; D017137:Nonoxynol