Rotenone at high concentrations inhibits NADH-fumarate reductase and the mitochondrial respiratory chain of Trypanosoma brucei and T. cruzi.
Hernandez
F R
FR
Department of Biomedical Sciences, University of South Alabama, Mobile 36688-0002, USA.
Turrens
J F
JF
D000818:Animals; D004579:Electron Transport / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects*; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000187:drug effects; D010088:Oxidoreductases / Q000187:drug effects*; D044925:Oxidoreductases Acting on CH-CH Group Donors; D015203:Reproducibility of Results; D012402:Rotenone / Q000494:pharmacology*; D014346:Trypanosoma brucei brucei / Q000187:drug effects* / Q000201:enzymology; D014349:Trypanosoma cruzi / Q000187:drug effects* / Q000201:enzymology; D014475:Uncoupling Agents
D014475:Uncoupling Agents; D012402:Rotenone; D010088:Oxidoreductases; D044925:Oxidoreductases Acting on CH-CH Group Donors; C020155:fumarate reductase (NADH); D016660:NAD(P)H Dehydrogenase (Quinone)