Chromatin transcription: clearing the gridlock.
A factor has been purified that specifically facilitates RNA chain elongation in a chromatin context; the properties of this factor help to define the challenges that lie ahead in understanding how RNA polymerase manages to transcribe DNA that is packaged into chromatin.
Geiduschek
E P
EP
Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla 92093-0634, USA. epg@jbiomail.ucsd.edu
D002843:Chromatin / Q000235:genetics*; D004247:DNA / Q000235:genetics; D004271:DNA, Fungal / Q000235:genetics; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D012313:RNA / Q000096:biosynthesis / Q000235:genetics; D012331:RNA, Fungal / Q000096:biosynthesis / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
D002843:Chromatin; D004271:DNA, Fungal; D012331:RNA, Fungal; D012313:RNA; D004247:DNA; D012321:DNA-Directed RNA Polymerases