title: [Interleukin-8 levels in gastric biopsies of children colonized by Helicobacter pylori].
abstract: BACKGROUND
  Helicobacter pylori produces a gastric mucosal inflammation characterized by neutrophil infiltration, due to the liberation of interleukin-8.
  
  
  OBJECTIVE
  To measure interleukin-8 levels in gastric mucosa samples from children colonized by H. pylori.
  
  
  METHODS
  Thirty one children that required an upper gastrointestinal endoscopy for diagnostic purpose were studied. Antral biopsies were obtained for pathological study, H. pylori detection using CLO-test and interleukin-8 determination by ELISA.
  
  
  RESULTS
  Nine children were not infected with H. pylori. Of these, six had a pathologically normal gastric mucosa and three had a mild chronic gastritis. Twenty two children were infected by H. pylori and all had a chronic gastritis with activity signs in 13. Mucosal interleukin-8 was higher in infected than in non infected children (59.7 (range 6.1-379.7) and 15.8 (range 3.9-104.1) pg/mg respectively p = 0.029). Colonized children with an active chronic gastritis had higher interleukin-8 levels than those with inactive gastritis (84.4 (range 33.3-379.0) and 26.8 (range 6.1-372.6) pg/ml respectively p = 0.04).
  
  
  CONCLUSIONS
  Stomach colonization by H. pylori is associated with higher mucosal levels of interleukin-8. This phenomenon probably plays a role in the genesis and intensity of gastric mucosal inflammation in children.
authors.affiliation: Departamento de Anatomía Patológica, Hospital Clínico San Borja-Arriarán.
authors.forename: E
authors.initials: E
authors.lastname: Chávez
authors.forename: F
authors.initials: F
authors.lastname: Sarmiento
authors.forename: M
authors.initials: M
authors.lastname: López
authors.forename: E
authors.initials: E
authors.lastname: Kakarieka
authors.forename: M T
authors.initials: MT
authors.lastname: Vial
authors.forename: M
authors.initials: M
authors.lastname: Gotteland
mesh_terms: D000293:Adolescent; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D005753:Gastric Mucosa / Q000737:chemistry* / Q000378:metabolism; D005756:Gastritis / Q000378:metabolism*; D016481:Helicobacter Infections / Q000378:metabolism*; D016480:Helicobacter pylori; D006801:Humans; D016209:Interleukin-8 / Q000032:analysis*; D008297:Male
chemical_list: D016209:Interleukin-8
vernacular_title: Niveles de interleuquina-8 en biopsias gástricas de niños colonizados por Helicobacter pylori.