title: Varicella-zoster virus infection in Australia.
abstract: OBJECTIVE
  To determine the epidemiology of varicella-zoster virus (VZV) infection in Australia using currently available data sources.
  
  
  METHODS
  Analysis of national death data (23 years), congenital and neonatal cases (one year) and attendances at sentinel general practices (two years); hospital admissions in NSW and SA (six years); serological studies in 1995 involving antenatal clinics in Sydney and Brisbane and child-care centre staff and refugees in Sydney; and case-ascertainment in 1995 in South Western Sydney among public hospital staff, child-care centre staff and the community.
  
  
  RESULTS
  In Australia, there have been an average of 3.5 deaths from chickenpox (mostly children) and 11 from herpes zoster (mostly older people) each year since 1980. The crude death rate for chickenpox has declined (p > 0.05). In 1995, there were 14 cases of neonatal and two of congenital varicella. Average annual admission rates for NSW and SA showed 1,200 hospital bed-days used for chickenpox, more than 20% with complications, and more than 7,300 bed days for zoster; annually more than 880 in-patient admissions were complicated by VZV. Most people encounter the virus in their first 15 years, but some remain susceptible into their 20s; 25% of cases and 37% of hospital admissions for chickenpox occur in people > or = 15 years of age.
  
  
  CONCLUSIONS
  VZV infection involves people of all ages. It causes substantial morbidity and mortality, particularly at the extremes of life. The death rate from chickenpox but not zoster has fallen since the introduction of acyclovir in the 1980s. Surveillance of VZV infection must be given priority once vaccines become available, to monitor changes in morbidity and mortality.
authors.affiliation: South Western Sydney Public Health Unit, New South Wales.
authors.forename: K G
authors.initials: KG
authors.lastname: Chant
authors.forename: E A
authors.initials: EA
authors.lastname: Sullivan
authors.forename: M A
authors.initials: MA
authors.lastname: Burgess
authors.forename: M J
authors.initials: MJ
authors.lastname: Ferson
authors.forename: J M
authors.initials: JM
authors.lastname: Forrest
authors.forename: L M
authors.initials: LM
authors.lastname: Baird
authors.forename: D I
authors.initials: DI
authors.lastname: Tudehope
authors.forename: M
authors.initials: M
authors.lastname: Tilse
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D001315:Australia / Q000453:epidemiology; D002644:Chickenpox / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology; D002648:Child; D002675:Child, Preschool; D005260:Female; D014645:Herpesvirus 3, Human / Q000302:isolation & purification*; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011159:Population Surveillance; D011247:Pregnancy; D012042:Registries; D012307:Risk Factors; D017678:Sex Distribution; D015996:Survival Rate