title: Sympathetic activation triggers systemic interleukin-10 release in immunodepression induced by brain injury.
abstract: The mechanism of immunodepression after brain injury is not yet clear. Here we demonstrate rapid systemic release of the immunoinhibitory cytokine interleukin-10, monocytic deactivation and a high incidence of infection in patients with 'sympathetic storm' due to acute accidental or iatrogenic brain trauma. In vitro studies showed that within minutes catecholamines trigger the secretion of interleukin-10 from unstimulated monocytes through a beta-adrenoreceptor-mediated, cAMP/protein kinase A-dependent pathway. We found that in a rat model of acute brain injury, the beta-receptor antagonist propranolol prevented the increase of interleukin-10 plasma levels. Rapid monocytic interleukin-10 release after sympathetic activation may represent a common pathway for immunodepression induced by stress and injury.
authors.affiliation: Department of Neurosurgery, Medical School Charité, Humboldt University, Berlin, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Woiciechowsky
authors.forename: K
authors.initials: K
authors.lastname: Asadullah
authors.forename: D
authors.initials: D
authors.lastname: Nestler
authors.forename: B
authors.initials: B
authors.lastname: Eberhardt
authors.forename: C
authors.initials: C
authors.lastname: Platzer
authors.forename: B
authors.initials: B
authors.lastname: Schöning
authors.forename: F
authors.initials: F
authors.lastname: Glöckner
authors.forename: W R
authors.initials: WR
authors.lastname: Lanksch
authors.forename: H D
authors.initials: HD
authors.lastname: Volk
authors.forename: W D
authors.initials: WD
authors.lastname: Döcke
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000328:Adult; D000368:Aged; D000818:Animals; D001921:Brain / Q000601:surgery; D001930:Brain Injuries / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D001932:Brain Neoplasms / Q000097:blood / Q000601:surgery; D001933:Brain Stem / Q000503:physiopathology; D002395:Catecholamines / Q000494:pharmacology; D006801:Humans; D007108:Immune Tolerance; D016753:Interleukin-10 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009380:Neoplasms, Nerve Tissue / Q000097:blood / Q000601:surgery; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000503:physiopathology*; D013565:Sympatholytics / Q000494:pharmacology; D013566:Sympathomimetics / Q000494:pharmacology
chemical_list: D000319:Adrenergic beta-Antagonists; D002395:Catecholamines; D013565:Sympatholytics; D013566:Sympathomimetics; D016753:Interleukin-10; D011433:Propranolol