Serum levels of macrophage-derived protein MRP-8/14 are elevated in active multiple sclerosis.
Serum concentrations of two macrophage-derived calcium-binding proteins, MRP-8 and MRP-8/14, were studied in 28 patients with relapsing multiple sclerosis (MS). Serum levels were determined with a commercially available sandwich ELISA and the one-tailed Mann-Whitney U test was used for statistical analysis. Median serum levels of MRP-8/14 were significantly higher in MS patients (5150 ng/ml) compared to 26 healthy controls (1482 ng/ml) and significantly higher in MS patients within an acute relapse (6690 ng/ml) compared to MS patients with stable disease (3050 ng/ml). MRP-8 levels were not elevated in MS patients. These results may indicate an early activation of macrophages in the formation of demyelinating MS plaques. In addition, increased serum levels of MRP-8/14 may prove to be a useful paraclinical disease activity parameter in MS patients.
Bogumil
T
T
Department of Neurology, University of Göttingen, Germany. tbogumi@gwdg.de
Rieckmann
P
P
Kubuschok
B
B
Felgenhauer
K
K
Brück
W
W
D000208:Acute Disease; D000943:Antigens, Differentiation / Q000097:blood*; D001327:Autoimmune Diseases / Q000097:blood*; D015415:Biomarkers; D002135:Calcium-Binding Proteins / Q000097:blood*; D040501:Calgranulin A; D002908:Chronic Disease; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D039841:Leukocyte L1 Antigen Complex; D008262:Macrophage Activation; D008562:Membrane Glycoproteins / Q000097:blood*; D009103:Multiple Sclerosis / Q000097:blood*; D019006:Neural Cell Adhesion Molecules / Q000097:blood*; D012008:Recurrence
D000943:Antigens, Differentiation; D015415:Biomarkers; D002135:Calcium-Binding Proteins; D040501:Calgranulin A; D039841:Leukocyte L1 Antigen Complex; D008562:Membrane Glycoproteins; D019006:Neural Cell Adhesion Molecules