title: Atypical cervical polyp with intracytoplasmic inclusions.
abstract: Benign polyps containing atypical stromal cells are described at many anatomical sites and some such lesions have been shown to contain intracytoplasmic actin-rich inclusions, believed to represent deranged filament metabolism in proliferating myofibroblastic cells. We present a case of an atypical cervical polyp with intracytoplasmic inclusions, occurring in a 23 year old female, and provide support for the proposal that these inclusions are composed of actin filaments, identical to those initially reported in infantile digital fibromatosis. This report emphasises the need to recognise the benign nature of such stromal proliferations and expands the range of myofibroblastic lesions in which actin inclusions may occur. Characterisation of the inclusions will provide further insight into the complexities of actin metabolism.
authors.affiliation: Department of Anatomical Pathology, The Western Australian Centre for Pathology and Medical Research, Nedlands, Australia.
authors.forename: K L
authors.initials: KL
authors.lastname: Yusoff
authors.forename: D V
authors.initials: DV
authors.lastname: Spagnolo
authors.forename: K I
authors.initials: KI
authors.lastname: Digwood
mesh_terms: D000199:Actins / Q000032:analysis; D000328:Adult; D003893:Desmin / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D002479:Inclusion Bodies / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D011127:Polyps / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D002583:Uterine Cervical Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure
chemical_list: D000199:Actins; D003893:Desmin