Effect of chronic administration of Tamoxifen on fertility in male bonnet monkeys (Macaca radiata).
Administration of Tamoxifen via the Alzet pump at a rate of 50 micrograms hr-1 for 90 days in the adult male bonnet monkeys Macaca radiata had no effect on the serum testosterone concentration determined at 10 AM and 10 PM as well as total sperm count determined at 15-day intervals over a period of 260 days. However, a significant reduction in sperm motility was observed beyond 90 days up until the 225th day. Breeding studies conducted from day 90 to 260 revealed that these males were infertile.
Rao
A J
AJ
Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, India.
Ramachandra
S G
SG
Ramesh
V
V
Krishnamurthy
H N
HN
Jayaraman
S
S
Gopalakrishnan
K
K
Juneja
H S
HS
D000818:Animals; D005298:Fertility / Q000187:drug effects*; D008251:Macaca; D008297:Male; D013076:Sperm Count / Q000187:drug effects*; D013077:Sperm Head / Q000187:drug effects; D013081:Sperm Motility / Q000187:drug effects*; D013082:Sperm Tail / Q000187:drug effects; D013094:Spermatozoa / Q000166:cytology* / Q000187:drug effects; D013629:Tamoxifen / Q000494:pharmacology*; D013739:Testosterone / Q000097:blood*; D013997:Time Factors
D013629:Tamoxifen; D013739:Testosterone