title: Adaptor proteins in lymphocyte antigen-receptor signaling.
abstract: Adaptor molecules, proteins that possess no intrinsic enzymatic function, but which mediate protein-protein interactions, have a critical role in integrating signal transduction pathways following engagement of cell-surface receptors. Several newly described adaptor molecules have been shown to serve important functions in the regulation of signaling events initiated by lymphocyte antigen receptors. Understanding how these adaptor proteins function to modulate signaling cascades will provide important insights into the complex biology of lymphocyte activation.
authors.affiliation: Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USA. ejpeter@blue.weeg.uiowa.edu
authors.forename: E J
authors.initials: EJ
authors.lastname: Peterson
authors.forename: J L
authors.initials: JL
authors.lastname: Clements
authors.forename: N
authors.initials: N
authors.lastname: Fang
authors.forename: G A
authors.initials: GA
authors.lastname: Koretzky
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D002352:Carrier Proteins / Q000502:physiology; D051380:GRB2 Adaptor Protein; D006801:Humans; D008213:Lymphocyte Activation / Q000502:physiology*; D008565:Membrane Proteins; D018448:Models, Immunological; D009687:Nuclear Proteins / Q000502:physiology; D010750:Phosphoproteins / Q000502:physiology; D011506:Proteins / Q000502:physiology; D017260:Receptor-CD3 Complex, Antigen, T-Cell / Q000276:immunology; D011947:Receptors, Antigen, B-Cell / Q000276:immunology*; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D015398:Signal Transduction / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology; D018909:src Homology Domains / Q000502:physiology
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C082869:CRKL protein; D002352:Carrier Proteins; C106957:FYB1 protein, human; D051380:GRB2 Adaptor Protein; C495948:GRB2 protein, human; C110810:LAT protein, human; D008565:Membrane Proteins; D009687:Nuclear Proteins; D010750:Phosphoproteins; D011506:Proteins; D017260:Receptor-CD3 Complex, Antigen, T-Cell; D011947:Receptors, Antigen, B-Cell; D011948:Receptors, Antigen, T-Cell; C108336:SKAP1 protein, human; C092947:SLP-76 signal Transducing adaptor proteins