Effect of intravenous vasopressin on endocochlear potential and systemic blood pressure in the guinea pig.
The effects of intravenous arginine-vasopressin (AVP) on the endocochlear potential (EP) and systemic blood pressure (BP) were examined in the guinea pig. Intravenous AVP (10(-7) M) elevated BP significantly but did not change EP. AVP (10(-8) M) produced a significant decrease in the amplitude of EP but did not change mean blood pressure significantly. AVP at 10(-9) M did not affect EP or BP. These results suggest that intravenous AVP might have an inhibitory effect on EP.
Nario
K
K
Department of Otolaryngology, Nara Medical University, Kashihara City, Japan.
Ueda
T
T
Murai
T
T
Miyahara
H
H
Matsunaga
T
T
D000818:Animals; D001127:Arginine Vasopressin / Q000008:administration & dosage / Q000494:pharmacology* / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D003055:Cochlear Microphonic Potentials / Q000187:drug effects* / Q000502:physiology; D006168:Guinea Pigs; D007262:Infusions, Intravenous; D014662:Vasoconstrictor Agents / Q000008:administration & dosage / Q000494:pharmacology*
D014662:Vasoconstrictor Agents; D001127:Arginine Vasopressin