title: Hemorrhagic and thrombotic complications in patients with myeloproliferative diseases.
abstract: OBJECTIVE
  To correlate the incidence of hemorrhage and thrombosis to bleeding time (BT) and platelet aggregation in 27 consecutive patients with myeloproliferative diseases (MPD).
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Public tertiary referral center.
  
  
  METHODS
  Eighteen patients with chronic myelogenous leukemia (CML), 5 with polycytemia vera (PV), 2 with essential thrombocytemia (ET) and 2 with idiopathic myelofibrosis (MF). Duke's BT and epinephrine-induced platelet aggregation were performed on the patients and on 10 healthy individuals.
  
  
  RESULTS
  Eleven patients presented symptoms (41%):9 with hemorrhage (33%) and 5 with thrombosis (19%). There were less symptomatic patients in the CML group (28%) than in the other MPD (67%), without statistical significance (Fisher, p = 0.06). Duke's BT was longer in symptomatic patients (Mann-Whitney, p < 0.05). Platelet aggregation was abnormal in 7 patients (26%) and 71% of them were symptomatic (Fisher, p = 0.07).
  
  
  CONCLUSIONS
  The high incidence of bleeding and thrombosis in patients with MPD was related to prolonged BT, but not to platelet aggregation abnormalities.
authors.affiliation: Department of Hematology, Universidade Federal de São Paulo, Brazil.
authors.forename: C V
authors.initials: CV
authors.lastname: Vignal
authors.forename: D M
authors.initials: DM
authors.lastname: Lourenço
authors.forename: M A
authors.initials: MA
authors.lastname: Noguti
authors.forename: M de L
authors.initials: Mde L
authors.lastname: Chauffaille
authors.forename: J
authors.initials: J
authors.lastname: Kerbauy
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001760:Bleeding Time; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D005500:Follow-Up Studies; D006470:Hemorrhage / Q000209:etiology*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000150:complications*; D010974:Platelet Aggregation / Q000187:drug effects; D010976:Platelet Count; D012189:Retrospective Studies; D013927:Thrombosis / Q000209:etiology*
chemical_list: D004837:Epinephrine