title: Epithelial anomalies in chronic pancreatitis as a risk factor of pancreatic cancer.
abstract: OBJECTIVE
  The relationship between chronic pancreatitis and the development of pancreatic cancer is still a matter of dispute. Our aim was to determine the frequency of hyperplastic, metaplastic and dysplastic epithelial anomalies in the course of chronic pancreatitis and the potential steps in their development to malignancy.
  
  
  METHODS
  The study was based on biopsy material of 70 patients with clinically diagnosed advanced chronic pancreatitis, who underwent partial or total pancreatectomy, as well as other operations. The patients were assigned to 2 groups: Group I (n = 41) with calcifying chronic pancreatitis; Group II (n = 29) with other forms of the disease. Histological sections were stained with hematoxylin-eosin, Mallory-azan, Gomori's silver method, and glycosaminoglycans (PAS and Alcian blue staining). Special interest was focused on the type and incidence of epithelial ductal and acinar cell anomalies, and on the degree of parenchymal scarring.
  
  
  RESULTS
  Hyperplasia of the ductal epithelium was present in 31.4%, focal squamous metaplasia in 21.4%, mucous metaplasia in 11.1%, cellular dysplasia in 8.6%, dysplastic acinar cell nodules in 21.4%, and "tubular complexes" in 30.0% of all cases. The differences in the frequency of these changes, except for ductal epithelial hyperplasia, were not statistically significant in two comparable groups. Advanced pancreatic fibrosis was associated with epithelial anomalies in 65.7% of all cases.
  
  
  CONCLUSIONS
  From the morphological point of view, the adequate prerequisites for the consideration of advanced forms of chronic pancreatitis, independent of type, as a risk factor of pancreatic cancer exist, necessitating the surgical removal of pathological lesions.
authors.affiliation: Department of Pathological Anatomy, Medical Academy, Bialystok, Poland.
authors.forename: B
authors.initials: B
authors.lastname: Cylwik
authors.forename: H F
authors.initials: HF
authors.lastname: Nowak
authors.forename: Z
authors.initials: Z
authors.lastname: Puchalski
authors.forename: J
authors.initials: J
authors.lastname: Barczyk
mesh_terms: D000328:Adult; D001706:Biopsy; D002908:Chronic Disease; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D005355:Fibrosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000473:pathology*; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D010195:Pancreatitis / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D012307:Risk Factors