title: An evaluation of the effect of an alpha hydroxy acid-blend skin cream in the cosmetic improvement of symptoms of moderate to severe xerosis, epidermolytic hyperkeratosis, and ichthyosis.
abstract: A number of genetic, intrinsic, and extrinsic factors can cause conditions of problem dry skin, marked by unusual dryness, rough texture, and extreme flaking and scaling, that are generally not controlled by conventional moisturizers. A study was undertaken to evaluate the safety and efficacy of two novel alpha hydroxy acid (AHA)-containing creams in reducing the appearance and symptoms of problem dry skin on subjects with a range of dry skin conditions, including xerosis, epidermolytic hyperkeratosis, and ichthyosis. Twenty subjects completed a course of treatment with either regular or extra strength AHA-blend cream on a test site, compared with a currently marketed, non-AHA moisturizing lotion on a control site. Subjects were treated for 4 weeks, with clinical evaluations performed at weeks 0, 2, and 4. The test for mulations reduced symptoms and improved cosmetic appearance following 2 weeks of use, with continued improvement following 4 weeks of use. Improvements were significant compared to baseline and compared to sites treated with the control lotion. Some patients experienced mild to moderate local adverse effects; all subjects were able to continue using the test product for the duration of the study.
authors.affiliation: Minnesota Clinical Study Center, Fridley 55432-3313, USA.
authors.forename: S
authors.initials: S
authors.lastname: Kempers
authors.forename: H I
authors.initials: HI
authors.lastname: Katz
authors.forename: R
authors.initials: R
authors.lastname: Wildnauer
authors.forename: B
authors.initials: B
authors.lastname: Green
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D003358:Cosmetics / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D006880:Hydroxy Acids / Q000008:administration & dosage*; D017488:Hyperkeratosis, Epidermolytic / Q000534:rehabilitation*; D007057:Ichthyosis / Q000534:rehabilitation*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012720:Severity of Illness Index; D016037:Single-Blind Method; D017592:Skin Care; D016896:Treatment Outcome
chemical_list: D003358:Cosmetics; D006880:Hydroxy Acids