Confirmation of an association between a polymorphism in exon 3 of the low-density lipoprotein receptor-related protein gene and Alzheimer's disease.
C766T, a polymorphism in exon 3 of the gene for the low-density lipoprotein receptor-related protein (LRP), was found to be associated with late-onset Alzheimer's disease (AD). We developed a PCR-restriction enzyme-based assay to analyze this allele in 234 AD patients and 103 controls. We confirmed that the LRP C766T polymorphism was in disequilibrium with AD--the C/C genotype was present in 76% of AD patients and 60% of controls (p < 0.01); however, the LRP polymorphism did not influence age at onset of AD.
Hollenbach
E
E
Alzheimer's Research Unit, Massachusetts General Hospital, Charlestown 02129, USA.
Ackermann
S
S
Hyman
B T
BT
Rebeck
G W
GW
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D002648:Child; D005091:Exons / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D026503:Low Density Lipoprotein Receptor-Related Protein-1; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D011971:Receptors, Immunologic / Q000235:genetics*
D001057:Apolipoproteins E; D026503:Low Density Lipoprotein Receptor-Related Protein-1; D011971:Receptors, Immunologic