title: Comparison of hydroxyapatite granules to autogenous bone graft in fusion cages in a goat model.
abstract: BACKGROUND
  With the increased use of fusion cages to achieve lumbar intervertebral fusion, the question arises as to the potential for bone ingrowth from the host bone through the entire cage. Is it even necessary to have an autogenous graft to achieve total bone incorporation?
  
  
  METHODS
  Nine adult male goats had fusion cages implanted into three vertebral bodies. The design was Surgical Dynamics/Ray Fusion Cage, measuring 21 mm x 14 mm. In each animal, one fusion cage was filled with autogenous graft, one with hydroxyapatite, porous granules, and the other with nonporous granules. Amount of new bone formation was determined by backscatter electron microscopy at 3 months post implantation in all animals.
  
  
  RESULTS
  The histologic section shows that there was total incorporation in all specimens at 3 months. There was slightly more new bone (43%) with the nonporous granules compared with the porous granules (35%). The amount of residual void space was about the same in all specimens, indicating that the amount of new bone formation was similar and not statistically different in cages filled with hydroxyapatite granules versus granules of autogenous bone.
  
  
  CONCLUSIONS
  This study confirms that total incorporation by ingrowth of new bone can be expected in fusion cages. The amount of ingrowth is about the same for autogenous graft versus hydroxyapatite granules. Apparently, it is not necessary to use bone graft to achieve successful bone incorporation if an acceptable biocompatable lattice, such as hydroxyapatite granules, is used.
authors.affiliation: University of California, San Diego, Department of Orthopaedics, USA.
authors.forename: V
authors.initials: V
authors.lastname: Mooney
authors.forename: J B
authors.initials: JB
authors.lastname: Massie
authors.forename: B I
authors.initials: BI
authors.lastname: Lind
authors.forename: J H
authors.initials: JH
authors.lastname: Rah
authors.forename: S
authors.initials: S
authors.lastname: Negri
authors.forename: R E
authors.initials: RE
authors.lastname: Holmes
mesh_terms: D000818:Animals; D016025:Bone Transplantation / Q000379:methods*; D004195:Disease Models, Animal; D017886:Durapatite; D006041:Goats; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D008297:Male; D008854:Microscopy, Electron; D011859:Radiography; D013123:Spinal Fusion / Q000295:instrumentation / Q000379:methods*; D014182:Transplantation, Autologous
chemical_list: D017886:Durapatite