Magnone A and B, novel anti-PAF tetrahydrofuran lignans from the flower buds of Magnolia fargesii.
In a search for platelet-activating-factor (PAF) antagonists, two new lignan compounds were isolated from the Chinese crude drug shin-i, the flower buds of Magnolia fargesii. Their structures were elucidated as (2S,3R,4R)-tetrahydro-2-(3,4-dimethoxyphenyl)-4-(3, 4-dimethoxybenzoyl)-3-(hydroxymethyl)furan (magnone A, 1) and (2S,3R, 4R)-tetrahydro-2-(3,4,5-trimethoxyphenyl)-4-(3, 4-dimethoxybenzoyl)-3-(hydroxymethyl)furan (magnone B, 2). Magnones A and B showed antagonistic activity against PAF in the [3H]PAF receptor binding assay with the IC50 values of 3.8 x 10(-5) M and 2.7 x 10(-5) M, respectively.
Jung
K Y
KY
Natural Product Biosynthesis Research Unit, Korea Research Institute of Bioscience & Biotechnology, Yusong P.O. Box 115, Taejon 305-600, Korea.
Kim
D S
DS
Oh
S R
SR
Park
S H
SH
Lee
I S
IS
Lee
J J
JJ
Shin
D H
DH
Lee
H K
HK
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects; D002396:Catechols / Q000302:isolation & purification* / Q000494:pharmacology; D002681:China; D005663:Furans / Q000302:isolation & purification* / Q000494:pharmacology; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010946:Plants, Medicinal / Q000737:chemistry*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D011817:Rabbits; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D002396:Catechols; D005663:Furans; D010972:Platelet Activating Factor; C113221:magnone A; C113222:magnone B