title: Cytogenetic analysis of hepatoblastoma: hypothesis of cytogenetic evolution in such tumors and results of a multicentric study.
abstract: Hepatoblastoma is a rare pediatric malignant tumor of the liver. Previous cytogenetic reports are sporadic. We karyotyped nine consecutive hepatoblastomas from the Italian centers participating in a multicentric study on hepatic tumors (SIOPEL 1). Six cases showed abnormal karyotypes. The most common abnormalities were trisomies of chromosomes 2 and 20. Four cases showed abnormalities of chromosome 1. On the basis of findings, we speculate the possibility of a cytogenetic evolutive pattern of hepatoblastomas.
authors.affiliation: Dipartimento di Pediatria, Università di Padova, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Sainati
authors.forename: A
authors.initials: A
authors.lastname: Leszl
authors.forename: M
authors.initials: M
authors.lastname: Stella
authors.forename: A
authors.initials: A
authors.lastname: Montaldi
authors.forename: G
authors.initials: G
authors.lastname: Perilongo
authors.forename: M
authors.initials: M
authors.lastname: Rugge
authors.forename: S
authors.initials: S
authors.lastname: Bolcato
authors.forename: A
authors.initials: A
authors.lastname: Iolascon
authors.forename: G
authors.initials: G
authors.lastname: Basso
mesh_terms: D002675:Child, Preschool; D002999:Clone Cells / Q000473:pathology; D005260:Female; D018197:Hepatoblastoma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D007621:Karyotyping; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000235:genetics / Q000473:pathology; D014407:Tumor Cells, Cultured