Novel thiazolidinedione derivatives with retinoid synergistic activity.
Several arylmethylidene thiazolidinediones were synthesized and their retinoidal activities were examined. TZ181 (7a), having a benzanilide skeleton, exhibited differentiation-inducing activity in HL-60 cell assay, while TZ191 (7b), the N-methylated analog of TZ181 (7a), TZ245 (9) and TZ335 (10) acted as retinoid synergists like the RXR-selective ligand, LGD1069 (5).
Ebisawa
M
M
Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan.
Kawachi
E
E
Fukasawa
H
H
Hashimoto
Y
Y
Itai
A
A
Shudo
K
K
Kagechika
H
H
D002454:Cell Differentiation / Q000187:drug effects; D004357:Drug Synergism; D018922:HL-60 Cells; D006801:Humans; D012176:Retinoids / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000494:pharmacology*
D012176:Retinoids; D013844:Thiazoles