Platelet-derived endothelial cell growth factor/thymidine phosphorylase expression correlated with tumor angiogenesis and macrophage infiltration in colorectal cancer.
To clarify whether platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP) expression in both tumor cells and stromal cells has independent or synergistic effects on tumor angiogenesis and progression and to explore a possible regulator for PD-ECGF/TP expression, immunohistochemical staining was conducted on 148 specimens of colorectal cancer. The microvessel count was significantly correlated with the extent of PD-ECGF/TP expression. Macrophage infiltration in tumors with positive TP was significantly higher than in tumors with negative TP (P < 0.001). The Cox model showed that PD-ECGF/TP expression was an independent prognostic factor, although the microvessel count had a stronger value in determining the patient prognosis.
Matsumura
M
M
The Second Department of Surgery, Fukui Medical University, Japan.
Chiba
Y
Y
Lu
C
C
Amaya
H
H
Shimomatsuya
T
T
Horiuchi
T
T
Muraoka
R
R
Tanigawa
N
N
D000230:Adenocarcinoma / Q000098:blood supply* / Q000201:enzymology* / Q000276:immunology; D000368:Aged; D015179:Colorectal Neoplasms / Q000098:blood supply* / Q000201:enzymology* / Q000276:immunology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008264:Macrophages / Q000276:immunology*; D008297:Male; D009389:Neovascularization, Pathologic; D017154:Stromal Cells / Q000201:enzymology; D013939:Thymidine Phosphorylase / Q000378:metabolism*
D013939:Thymidine Phosphorylase