[Chemotherapy repeated injection via pelvic retroperitoneal cannulation].
OBJECTIVE
To investigate the feasibility of chemotherapy for lymphatic metastases of gynecologic cancer by repeated injection via pelvic retroperitoneal cannulation.


METHODS
5-fluorouracil (5-FU), thiotepa, methofrexate were repeatedly injected into the pelvic retroperitoneal space of 25 dogs and 24 patients respectively via cannulation. Microscope and high-performance liquid chromatography were used to observe the drug concentration of 5-FU and pathologic changes of the involved tissues.


RESULTS
Animal experiment showed no toxicity to vessels, ureter and the normal tissues involved; nodal 5-FU concentration of repeated injection side was 7 to 9 times of that on the peripheral connective tissue (P < 0.05). Clinical study revealed: (1) the external iliac, hypogastric, obturator, deep inguinal and most of the common iliac lymph nodes were submerged in the 5-FU solution; (2) pelvic and periaortic nodal 5-FU concentrations of repeated injection side were 20 to 73 and 27 to 110 times of that on single injection side respectively; nodal 5-FU concentration was 11 to 20 times of that on the peripheral connective tissue; (3) metastatic cancer cells of nodal in the study group showed obvious degeneration and necrosis while no changes in the control; (4) no severe complications or adverse effects were observed.


CONCLUSIONS
Repeated injection via pelvic retroperitoneal cannulation was feasible and probably more effective for the treatment of lymphatic metastases of gynecologic cancer.
Cao
Z
Z
Second Affiliated Hospital, West China University of Medical Sciences, Chengdu.
Zhang
D
D
Peng
Z
Z
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002408:Catheters, Indwelling; D004285:Dogs; D016889:Endometrial Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008207:Lymphatic Metastasis; D008727:Methotrexate / Q000008:administration & dosage; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology; D010388:Pelvis; D011897:Random Allocation; D012187:Retroperitoneal Space; D013852:Thiotepa / Q000008:administration & dosage
D013852:Thiotepa; D005472:Fluorouracil; D008727:Methotrexate