title: Body composition in patients treated with peritoneal dialysis.
abstract: BACKGROUND
  Malnutrition is a common complication in uremia and during maintenance dialysis. Several factors contribute to its development. Different modes of dialysis treatment may differ in their effects on nutritional status.
  
  
  METHODS
  In order to analyse the nutritional consequences of peritoneal dialysis (PD), body composition analyses were performed in PD patients between February 1993 and March 1996. Body cell mass (BCM) was estimated from measurements of total body potassium (TBK) in a whole-body counter. Total body water (TBW) was determined by measurement of tritiated water. Body fat (BF) was calculated from body weight (BW), TBK and TBW. Observed values were related to predicted (o/p) derived from local population studies.
  
  
  RESULTS
  Sixty patients were repeatedly investigated during the study period. Of these, 34 were investigated during the first year of PD. At the start of dialysis, TBK o/p was 0.94 and BF o/p 0.76. No change in body composition was seen during the observation period in the group as a whole. However, within the group individual changes in BW were strongly correlated with individual changes in BF (r=0.66, P=0.0001). Twenty-six patients were examined during the second and third year of PD. In this group, BW o/p remained constant over time. However, there was a small but significant decline of TBK o/p and a concomitant increase of BF o/p (P<0.05). No correlation was observed between changes in TBK and changes in serum albumin.
  
  
  CONCLUSIONS
  The results of this study indicate, that there may be a risk for further reduction of body cell mass during long-term PD treatment, while body energy stores are maintained or even increased.
authors.affiliation: Department of Nephrology, Sahlgrenska University Hospital, Göteborg, Sweden.
authors.forename: A C
authors.initials: AC
authors.lastname: Johansson
authors.forename: O
authors.initials: O
authors.lastname: Samuelsson
authors.forename: B
authors.initials: B
authors.lastname: Haraldsson
authors.forename: I
authors.initials: I
authors.lastname: Bosaeus
authors.forename: P O
authors.initials: PO
authors.lastname: Attman
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001823:Body Composition; D001834:Body Water / Q000378:metabolism; D001835:Body Weight; D018753:Diet, Protein-Restricted; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009748:Nutrition Disorders / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D009752:Nutritional Status; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D011188:Potassium / Q000378:metabolism; D013997:Time Factors; D014511:Uremia / Q000150:complications / Q000178:diet therapy / Q000628:therapy
chemical_list: D011188:Potassium