title: Magnone A and B, novel anti-PAF tetrahydrofuran lignans from the flower buds of Magnolia fargesii.
abstract: In a search for platelet-activating-factor (PAF) antagonists, two new lignan compounds were isolated from the Chinese crude drug shin-i, the flower buds of Magnolia fargesii. Their structures were elucidated as (2S,3R,4R)-tetrahydro-2-(3,4-dimethoxyphenyl)-4-(3, 4-dimethoxybenzoyl)-3-(hydroxymethyl)furan (magnone A, 1) and (2S,3R, 4R)-tetrahydro-2-(3,4,5-trimethoxyphenyl)-4-(3, 4-dimethoxybenzoyl)-3-(hydroxymethyl)furan (magnone B, 2). Magnones A and B showed antagonistic activity against PAF in the [3H]PAF receptor binding assay with the IC50 values of 3.8 x 10(-5) M and 2.7 x 10(-5) M, respectively.
authors.affiliation: Natural Product Biosynthesis Research Unit, Korea Research Institute of Bioscience & Biotechnology, Yusong P.O. Box 115, Taejon 305-600, Korea.
authors.forename: K Y
authors.initials: KY
authors.lastname: Jung
authors.forename: D S
authors.initials: DS
authors.lastname: Kim
authors.forename: S R
authors.initials: SR
authors.lastname: Oh
authors.forename: S H
authors.initials: SH
authors.lastname: Park
authors.forename: I S
authors.initials: IS
authors.lastname: Lee
authors.forename: J J
authors.initials: JJ
authors.lastname: Lee
authors.forename: D H
authors.initials: DH
authors.lastname: Shin
authors.forename: H K
authors.initials: HK
authors.lastname: Lee
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000187:drug effects; D002396:Catechols / Q000302:isolation & purification* / Q000494:pharmacology; D002681:China; D005663:Furans / Q000302:isolation & purification* / Q000494:pharmacology; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010946:Plants, Medicinal / Q000737:chemistry*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D011817:Rabbits; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D002396:Catechols; D005663:Furans; D010972:Platelet Activating Factor; C113221:magnone A; C113222:magnone B