[Anticoagulant and fibrinolytic effects of proline-containing peptides].
Anticoagulant, fibrinolytic, and fibrin-depolymerization effects were revealed during in vitro study of five proline-containing peptides (Gly-Pro, Trp-Pro, Pro-Gly, Gly-Pro-Gly-Gly, and Pro-Gly-Pro) in the concentration range 10(-9) to 10(-1) mg/ml. Intravenous injection of Trp-Pro and Pro-Gly into white rats at 250 micrograms/kg body weight significantly increased recalcification time and activated partial thromboplastin time of serum coagulation, increased fibrinolytic activity, decreased the level of serum factor XIII/(/)a and fibrinogen, and reduced thrombocyte aggregation. We propose inhibition of thromboplastin and thrombin formation in the serum by the studied proline-containing peptides both in vitro and in vivo.
Pastorova
V E
VE
Biology Faculty, Moscow State University, Moscow, Russia.
Liapina
L A
LA
Smolina
T Iu
TIu
Ashmarin
I P
IP
D000818:Animals; D000925:Anticoagulants / Q000008:administration & dosage / Q000494:pharmacology*; D004151:Dipeptides / Q000008:administration & dosage / Q000494:pharmacology; D005340:Fibrinogen / Q000032:analysis; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D006487:Hemostasis / Q000187:drug effects; D066298:In Vitro Techniques; D007275:Injections, Intravenous; D008297:Male; D009842:Oligopeptides / Q000008:administration & dosage / Q000494:pharmacology*; D010314:Partial Thromboplastin Time; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D011392:Proline / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D051381:Rats; D011503:Transglutaminases / Q000032:analysis
D000925:Anticoagulants; D004151:Dipeptides; D005343:Fibrinolytic Agents; D009842:Oligopeptides; D010975:Platelet Aggregation Inhibitors; C113164:prolyl-glycyl-proline; C113296:tryptophyl-proline; C113165:glycyl-prolyl-glycyl-glycine; C057749:prolylglycine; C015248:glycylproline; D005340:Fibrinogen; D011392:Proline; D011503:Transglutaminases
Antikoaguliantnye i fibrinoloticheskie éffekty nekotorykh prolinsoderzhashchikh peptidov.