Effect of dexamethasone on Glu-IR and GABA-IR neurons of hippocampus in rats.
Dexamethasone (Dex) was injected into the rat lateral ventricle and the changes of glutamate-immunoreactivity (Glu-IR) and gamma-aminobulyric acid immunoreactivity (GABA-IR) neurons in the hippocampus were immunocytochemically examined 2 h after injection. The results showed that Glu-IR neurons increased and GABA-IR neurons did not show marked change. The mechanism remains to be further studied.
Liu
R
R
Department of Anatomy, Tongji Medical University, Wuhan.
Liu
Y
Y
Zhu
C
C
D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology*; D005938:Glucocorticoids / Q000494:pharmacology*; D005973:Glutamine / Q000378:metabolism*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D007276:Injections, Intraventricular; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005938:Glucocorticoids; D005973:Glutamine; D005680:gamma-Aminobutyric Acid; D003907:Dexamethasone