[Mechanism of severe, immediate reactions to iodinated contrast material].
Immediate reactions to iodinated contrast material are usually supposed to be due to complement activation. Histamine has not been proved responsible for signs. However the results described in the literature are controversial: they have been obtained from non-reacting patients or during minor or moderate reactions. We suggest to study mediator release during unexpected severe reactions and to perform skin tests and IgE measurements in patients with proved liberation of mediators.
Laroche
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Service de Biophysique Médicale-C.H.R.U. de Caen, France.
D000707:Anaphylaxis / Q000276:immunology; D018681:Anesthetics, General / Q000009:adverse effects; D003167:Complement Activation; D003287:Contrast Media / Q000009:adverse effects*; D006632:Histamine / Q000502:physiology; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D017613:Iodine Compounds / Q000009:adverse effects* / Q000276:immunology
D018681:Anesthetics, General; D003287:Contrast Media; D017613:Iodine Compounds; D007073:Immunoglobulin E; D006632:Histamine
Mécanismes des réactions immédiates sévères aux produits de contraste iodés.