Drug eruption due to Bufferin showing erythema exsudativum multiforme with a photo-recall-like phenomenon.
A 21-year-old woman who had been taking several kinds of analgesics to treat dysmenorrhea developed episodic attacks of a purpuric macular eruption and a burning sensation on unexposed areas of the upper chest and back where she had sustained severe sunburn eight months earlier. Target-like lesions developed on these areas after intake of Bufferin, a combination of aspirin and dialuminate. After the eruptions had abated following systemic administration of a corticosteroid agent, a challenge test was performed, using a quarter of a tablet of Bufferin. The patient developed a temporary burning sensation and a erythematous color on the previously sunburned skin. We diagnosed this case as a drug eruption due to Bufferin showing erythema exsudativium multiforme with a photo-recall-like phenomenon. In our case, skin tests would be useful to confirm the causal drug.
Lee
S G
SG
Department of Dermatology, Faculty of Medicine, Kyoto University, Kyoto, 6068507 Japan.
Matsuyoshi
N
N
Ohta
K
K
Horiguchi
Y
Y
Imamura
S
S
D000328:Adult; D001241:Aspirin / Q000009:adverse effects* / Q000627:therapeutic use; D001707:Biopsy, Needle; D017454:Dermatitis, Photoallergic / Q000175:diagnosis / Q000473:pathology*; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology*; D004412:Dysmenorrhea / Q000188:drug therapy; D004892:Erythema Multiforme / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D006801:Humans; D012882:Skin Tests
D001241:Aspirin