[Bone matrix proteins].
Bone matrix is composed of collagen and non-collagenous proteins. The collagen is mainly type I collagen. Characteristics of bone collagen are in posttranslational modifications and utilization of transcriptional elements in the promoter. The non-collagenous proteins are acidic Ca-binding proteins: bone Gla protein(BGP), bone sialoprotein (BSP), osteopontin, osteonectin etc. BGP and BSP are specific to bone, and other proteins are present also in non-mineralized tissues. BGP functions in suppression of excessive mineralization. BSP and osteopontin are sialoproteins containing a RGD cell-attachment sequence and poly(acidic amino acid) sequences. BSP is present in sites of bone formation. Osteopontin is involved in attachment of osteoclasts to bone surface.
Fujisawa
R
R
Department of Biochemistry, School of Dentistry, Hokkaido University.
Kuboki
Y
Y
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D002135:Calcium-Binding Proteins / Q000502:physiology*; D003094:Collagen / Q000502:physiology; D016326:Extracellular Matrix Proteins; D006801:Humans; D058574:Integrin-Binding Sialoprotein; D053495:Osteopontin; D012795:Sialoglycoproteins / Q000502:physiology; D000097568:Matrix Gla Protein
D002135:Calcium-Binding Proteins; D003094:Collagen; D016326:Extracellular Matrix Proteins; D058574:Integrin-Binding Sialoprotein; D053495:Osteopontin; D012795:Sialoglycoproteins; D000097568:Matrix Gla Protein; C546871:IBSP protein, human; C506895:SPP1 protein, human