title: Comparison of thrombolytic therapy of lower-extremity acute, subacute, and chronic arterial occlusions.
abstract: Our purpose was to study the effectiveness of thrombolytic therapy in treating acute, subacute, and chronic arterial occlusions in a multicenter retrospective study. Intraarterial urokinase infusion was performed in 235 patients for occluded native arteries. There were 70 (30%) with acute and 26 (5%) with subacute occlusions, and 141 (59%) with chronic symptoms for longer than 3 mo. Complete thrombolysis was achieved in 60 (86%) of the acute, 20 (77%) of the subacute, and 106 (75%) of the chronic occlusions. Adjunctive interventional procedures were performed as needed. Long-term follow-up revealed a primary patency of 87%, 85%, and 76% for the acute, subacute, and chronic occlusion groups, respectively. We conclude that the rate of complete thrombolysis of chronic occlusions proved slightly more efficient for acute and virtually the same for subacute occlusions. Long-term follow-up demonstrated a higher failure rate with chronic than with acute occlusions, probably due to worsened peripheral vascular runoff.
authors.affiliation: Department of Interventional Radiology, Louisiana State University School of Medicine, New Orleans, USA.
authors.forename: M H
authors.initials: MH
authors.lastname: Wholey
authors.forename: M A
authors.initials: MA
authors.lastname: Maynar
authors.forename: M H
authors.initials: MH
authors.lastname: Wholey
authors.forename: J M
authors.initials: JM
authors.lastname: Pulido-Duque
authors.forename: R
authors.initials: R
authors.lastname: Reyes
authors.forename: C R
authors.initials: CR
authors.lastname: Jarmolowski
authors.forename: W R
authors.initials: WR
authors.lastname: Castaneda
mesh_terms: D000208:Acute Disease; D000368:Aged; D000792:Angiography; D017130:Angioplasty; D001157:Arterial Occlusive Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery; D002908:Chronic Disease; D004691:Endarterectomy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007261:Infusions, Intra-Arterial; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D010960:Plasminogen Activators / Q000008:administration & dosage*; D012189:Retrospective Studies; D015607:Stents; D017131:Thrombectomy; D015912:Thrombolytic Therapy; D016896:Treatment Outcome; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage*
chemical_list: D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator