Phospholipid-binding activity of human mannan-binding lectin.
Some C-type lectins possess phospholipid-binding ability, which may be of physiological importance. Human mannan-binding lectin (MBL) was found to bind specifically to solid-phase phosphatidylserine (PS), phosphatidylinositol (PI) and phosphatidylcholine (PC), but not cardiolipin (CL), in a concentration-dependent manner. This property was inhibited by EDTA and by monosaccharides, and exhibited a similar pH dependence to the carbohydrate (mannan)-binding activity of MBL. These findings may be of immunological relevance.
Kilpatrick
D C
DC
Department of Transfusion Medicine, Edinburgh, Scotland, UK. 100436.51@compuserve.com
D000818:Animals; D002308:Cardiolipins / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism*; D002417:Cattle; D037222:Collectins; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009005:Monosaccharides / Q000378:metabolism; D010713:Phosphatidylcholines / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism; D010718:Phosphatidylserines / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*
D002308:Cardiolipins; D002352:Carrier Proteins; D037222:Collectins; D009005:Monosaccharides; D010713:Phosphatidylcholines; D010716:Phosphatidylinositols; D010718:Phosphatidylserines; D010743:Phospholipids