title: Low density lipoprotein receptor related protein gene exon 3 polymorphism association with Alzheimer's disease in Chinese.
abstract: Since apolipoprotein E4 (apoE4) is the major genetic risk for late onset Alzheimer's disease (AD), proteins that interact with apoE might be involved in AD pathogenesis. Low density lipoprotein receptor related protein (LRP) is an apoE receptor in the brain. In exon 3 of the LRP gene a polymorphism was found to be underrepresented in AD compared to normal Caucasian subjects (N). We examined this polymorphism in Chinese AD and N subjects. The polymorphism frequency in N was roughly half that reported for Caucasians. Compared to N, the frequency was significantly decreased in pathologically diagnosed, but not in clinically diagnosed AD patients. Thus, the role of the LRP exon 3 polymorphism in AD has now been demonstrated in two ethnic groups, suggesting the importance of LRP in AD pathogenesis.
authors.affiliation: Department of Chemical Pathology, Chinese University of Hong Kong, Shatin.
authors.forename: L
authors.initials: L
authors.lastname: Baum
authors.forename: L
authors.initials: L
authors.lastname: Chen
authors.forename: H K
authors.initials: HK
authors.lastname: Ng
authors.forename: Y S
authors.initials: YS
authors.lastname: Chan
authors.forename: Y T
authors.initials: YT
authors.lastname: Mak
authors.forename: J
authors.initials: J
authors.lastname: Woo
authors.forename: H F
authors.initials: HF
authors.lastname: Chiu
authors.forename: C P
authors.initials: CP
authors.lastname: Pang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics* / Q000378:metabolism; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005091:Exons / Q000235:genetics*; D006723:Hong Kong; D006801:Humans; D026503:Low Density Lipoprotein Receptor-Related Protein-1; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D018807:Polymorphism, Single-Stranded Conformational; D011971:Receptors, Immunologic / Q000235:genetics*; D011973:Receptors, LDL / Q000235:genetics*; D012307:Risk Factors
chemical_list: D001057:Apolipoproteins E; D026503:Low Density Lipoprotein Receptor-Related Protein-1; D011971:Receptors, Immunologic; D011973:Receptors, LDL