Lack of association between outcome measures of nerve regeneration.
Studies of nerve regeneration in rodents utilize at least one of three classes of outcome measures: electrophysiology, morphometry, and functional tests. The assumption that these measures are correlated was tested utilizing a data set of 16 variables. Significant correlations (Spearman's rho, P < or = 0.05) were found within variable classes; however, none were found between classes. The three commonly utilized outcome measures do not measure the same phenomenon but rather discrete aspects of nerve regeneration.
Munro
C A
CA
Department of Surgery, Sunnybrook Health Science Centre, University of Toronto, North York, ON, Canada.
Szalai
J P
JP
Mackinnon
S E
SE
Midha
R
R
D000818:Animals; D004594:Electrophysiology; D009043:Motor Activity / Q000502:physiology*; D009416:Nerve Regeneration / Q000502:physiology*; D010523:Peripheral Nervous System Diseases / Q000473:pathology / Q000503:physiopathology*; D051381:Rats; D011917:Rats, Inbred Lew; D013979:Tibial Nerve / Q000293:injuries* / Q000473:pathology / Q000637:transplantation; D016896:Treatment Outcome; D016138:Walking / Q000502:physiology