[Changes in the structure of the nucleus of neocortical neurons during deficiency of serotonin and catecholamines].
The study was taken on Wistar rats using selective neurotoxins 5,7-dihydroxytriptamine and 6-hydroxydopamine. The reaction of neocortical neurons to monoamine depletion was examined. Alterations in chromatin distribution and partial nucleolar segregation were detected in cell nuclei of some neurons. Peculiar intranuclear inclusions, persisting for a long period, are also found out. We propose that detected changes in the nuclear structure are due to intracellular adaptive reactions associated with alterations in nuclear-cytoplasmic transport and protein synthesis.
Otellin
V A
VA
Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg.
Neokesariĭskiĭ
A A
AA
Korzhevskiĭ
D E
DE
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism / Q000648:ultrastructure; D004298:Dopamine / Q000172:deficiency*; D008297:Male; D019579:Neocortex / Q000378:metabolism / Q000648:ultrastructure*; D009474:Neurons / Q000378:metabolism / Q000648:ultrastructure*; D009638:Norepinephrine / Q000172:deficiency*; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000172:deficiency*
D012701:Serotonin; D004298:Dopamine; D009638:Norepinephrine
Izmeneniia struktury iader neĭronov neokorteksa v usloviiakh defitsita serotonina i katekholaminov.