[N-3 polyunsaturated fatty acids in surgical nutrition].
Recent surgical nutrition includes the management of mediator to induce the stress response and immune function. N-3 polyunsaturated fatty acid (n-3 PUFA) were reported to increase the survival rate, and to improve the nutritional and immune status of septic or burned animals. N-3 PUFA also inhibited the proliferation and metastasis of cancer, and improved the cancer cachexia. N-3 PUFA decreased the production of cytokine and eicosanoid originated from n-6 PUFA, and reduced the inflammatory and stress response. Cell-mediated immunity was suppressed with the reduction of cytokine. But in the stressed state, N-3 PUFA ameliorated the stress induced immunosuppression. Alteration of transcription of cytokine mRNA, changes of membrane fluidity, and reduced expression of adhesion molecule were proposed to interpret these effects. In conclusion, n-3 PUFA can be applied for the surgical patients, especially for the critically ill patients.
Tashiro
T
T
First Department of Surgery, Chiba University School of Medicine, Japan.
Yamamori
H
H
Morishima
Y
Y
Sugiura
T
T
Hayashi
N
N
Furukawa
K
K
Nakajima
N
N
Itoh
I
I
D000818:Animals; D015815:Cell Adhesion Molecules / Q000378:metabolism; D016638:Critical Illness / Q000628:therapy; D016207:Cytokines / Q000378:metabolism; D015777:Eicosanoids / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007249:Inflammation / Q000378:metabolism / Q000628:therapy; D008560:Membrane Fluidity / Q000187:drug effects; D009369:Neoplasms / Q000628:therapy; D010289:Parenteral Nutrition, Total; D013312:Stress, Physiological / Q000628:therapy
D015815:Cell Adhesion Molecules; D016207:Cytokines; D015777:Eicosanoids; D005231:Fatty Acids, Unsaturated