title: Treatment of hemangioblastomas in von Hippel-Lindau disease with linear accelerator-based radiosurgery.
abstract: OBJECTIVE
  Stereotactic radiosurgery is increasingly being used to treat hemangioblastomas, particularly those that are in surgically inaccessible locations or that are multiple, as is common in von Hippel-Lindau disease. The purpose of this study was to retrospectively evaluate the effectiveness of radiosurgery in the treatment of hemangioblastomas.
  
  
  METHODS
  From 1989 to 1996, 29 hemangioblastomas in 13 patients with von Hippel-Lindau disease were treated with linear accelerator-based radiosurgery. The mean patient age was 40 years (range, 31-57 yr). The radiation dose to the tumor periphery averaged 23.2 Gy (range, 18-40 Gy). The mean tumor volume was 1.6 cm3 (range, 0.07-65.4 cm3). Tumor response was evaluated in serial, contrast-enhanced, computed tomographic and magnetic resonance imaging scans. The mean follow-up period was 43 months (range, 11-84 mo).
  
  
  RESULTS
  Only one (3%) of the treated hemangioblastomas progressed. Five tumors (17%) disappeared, 16 (55%) regressed, and 7 (24%) remained unchanged in size. Five of nine patients with symptoms referable to treated hemangioblastomas experienced symptomatic improvement. During the follow-up period, one patient died as a result of progression of untreated hemangioblastomas in the cervical spine. Three patients developed radiation necrosis, two of whom were symptomatic.
  
  
  CONCLUSIONS
  Although follow-up monitoring is limited, stereotactic radiosurgery provides a high likelihood of local control of hemangioblastomas and is an attractive alternative to multiple surgical procedures for patients with von Hippel-Lindau disease.
authors.affiliation: Department of Neurosurgery, Stanford University Medical Center, California 94305, USA.
authors.forename: S D
authors.initials: SD
authors.lastname: Chang
authors.forename: J A
authors.initials: JA
authors.lastname: Meisel
authors.forename: S L
authors.initials: SL
authors.lastname: Hancock
authors.forename: D P
authors.initials: DP
authors.lastname: Martin
authors.forename: M
authors.initials: M
authors.lastname: McManus
authors.forename: J R
authors.initials: JR
authors.lastname: Adler
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D018325:Hemangioblastoma / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery; D012189:Retrospective Studies; D013120:Spinal Cord Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D015996:Survival Rate; D016896:Treatment Outcome; D006623:von Hippel-Lindau Disease / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*