title: Antimicrobial susceptibility of Moraxella bovis.
abstract: The antimicrobial susceptibility of 55 isolates of Moraxella bovis to seven antibiotics was evaluated by broth microdilution procedures. The isolates had an MIC90 of < or = 1 mg/l to erythromycin, ceftiofur, and ampicillin; 4 mg/l to tilmicosin; 16 mg/l to tylosin and gentamicin; and had MIC90s of > or = 32 mg/l for oxytetracycline. The modal MIC values for these antibiotics were as follows: ampicillin, < 0.25 mg/l; ceftiofur, < or = 0.125 mg/l; tilmicosin, 2 mg/l; tylosin, 8 mg/l; erythromycin 1 mg/l; oxytetracycline, < or = 0.5 mg/l; and gentamicin, < or = 0.5 mg/l. This in vitro data showed most antibiotics have low MICs that are suggestive of clinical efficacy.
authors.affiliation: Animal Science Discovery and Development Research, Elanco Animal Health, Greenfield, IN 46140, USA. trs@lilly.com
authors.forename: T R
authors.initials: TR
authors.lastname: Shryock
authors.forename: D W
authors.initials: DW
authors.lastname: White
authors.forename: C S
authors.initials: CS
authors.lastname: Werner
mesh_terms: D000667:Ampicillin / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002417:Cattle; D002511:Cephalosporins / Q000494:pharmacology; D004917:Erythromycin / Q000494:pharmacology; D005839:Gentamicins / Q000494:pharmacology; D007639:Keratoconjunctivitis, Infectious / Q000382:microbiology*; D018942:Macrolides; D008826:Microbial Sensitivity Tests / Q000379:methods; D016955:Moraxella bovis / Q000187:drug effects* / Q000302:isolation & purification; D016870:Neisseriaceae Infections / Q000382:microbiology / Q000662:veterinary; D010118:Oxytetracycline / Q000494:pharmacology; D015645:Tylosin / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D005839:Gentamicins; D018942:Macrolides; D004917:Erythromycin; D000667:Ampicillin; C053503:ceftiofur; D010118:Oxytetracycline; C052319:tilmicosin; D015645:Tylosin