Chronic myelogenous leukemia: extending the prospects for cure.
Advances in our understanding of the molecular defects underlying this leukemia have led to novel therapeutic approaches that have not only altered the natural history of the disease but also apparently effected cures in some patients. The next step may be to offer the possibility of a cure to all patients. Allogeneic bone marrow and T cell transplantation shows promise in this regard.
Mathias
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University of Pennsylvania, School of Medicine, Philadelphia, USA.
Wakoff
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Porter
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D016026:Bone Marrow Transplantation; D018450:Disease Progression; D006801:Humans; D016219:Immunotherapy, Adoptive; D007372:Interferons / Q000627:therapeutic use; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood / Q000235:genetics / Q000628:therapy*; D010677:Philadelphia Chromosome; D013601:T-Lymphocytes / Q000637:transplantation; D014178:Translocation, Genetic
D007372:Interferons