title: [Development and use of erythrocyte diagnosticums for the detection of rickettsiae and antibodies to them].
abstract: The hemosensitizing activity of different fractions of antirickettsial sera, obtained from horses in the process immunization (primary sera) and remote reimmunization (reimmune sera), was studied. The study revealed that in the process of hemosensitization the leading role was played by IgM of primary sera and IgG of reimmune sera, the latter having the most active hemosensitizing properties. The inhibiting action of ballast proteins on the process of hemosensitization was demonstrated. On the model of antirickettsial sera obtained at different stages of the immunization of animals with R.prowazekii the possibility of using the reaction of antigen neutralization, made with the use of different working doses of the antigen, for the differentiation of primary and repeated immune response was shown. The mechanism of such modified variant of the reaction of antigen neutralization is considered and the possibility of using it for the differentiation of epidemic typhus and Brill's disease is discussed.
authors.forename: A V
authors.initials: AV
authors.lastname: Misenzhnikov
mesh_terms: D000907:Antibodies, Bacterial / Q000096:biosynthesis / Q000097:blood*; D004912:Erythrocytes / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood*; D012281:Rickettsia / Q000276:immunology*; D012698:Serologic Tests / Q000379:methods*
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D007075:Immunoglobulin M
vernacular_title: Razrabotka i primenenie éritrotsitarnykh diagnostikumov dlia vyiavleniia rikketsiĭ i antitel k nim.