Effects of pentoxifylline on some peripheral blood parameters and haemostasis in acute pulmonary tissue injury after cyclophosphamide.
Cyclophosphamide (CP) is one of the widely used cytostatic drugs, with a strong toxic influence on pulmonary tissue. Experimental works have shown that a single high dose of CP causes injury to all elements of the interalveolar septum, especially to the alveolar endothelial and epithelial cells. The aim of this work was to evaluate the influence of pentoxifylline (PTXF) (30 mg/kg b.w.) on the ultrastructure of lungs capillaries and blood cell count as well as plasma fibrinogen levels in Wistar rats after intraperitoneal injection of 150 mg/b.w. CP. We established that in the doses applied PTXF had no statistically significant influence on the number of leukocytes and erythrocytes determined in the left ventricular blood of rats receiving CP, while the number of white cells from animals given PTXF only was higher than in controls. There was a smaller decrease in the number of platelets (p < 0.05) and smaller reduction in fibrinogen level (p < 0.01) in the serum of PTXF-CP animals than in the CP group. The results obtained suggest a protective effect of PTXF on CP induced changes, which have been evidenced in some of the parameters examined. Ultrastructural examinations found the lungs to be the organ of extramedullary thrombocytopoiesis in CP-treated animals and revealed that platelet accumulation in the system of lung capillaries was a potential cause of the decrease observed in the number of blood platelets following CP administration.
Sulkowska
M
M
Department of Pathological Anatomy, Medical Academy of Białystok.
Musiatowicz
B
B
Sulkowski
S
S
Giedrojć
J
J
Sulik
M
M
Jakubowski
A
A
Terlikowski
S
S
Pasztaleniec
L
L
Baltaziak
M
M
Sobaniec-Lotowska
M
M
D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000633:toxicity*; D001772:Blood Cell Count / Q000187:drug effects*; D002196:Capillaries / Q000187:drug effects / Q000648:ultrastructure; D003520:Cyclophosphamide / Q000633:toxicity*; D004347:Drug Interactions; D006487:Hemostasis / Q000187:drug effects*; D008168:Lung / Q000098:blood supply* / Q000187:drug effects; D008297:Male; D008854:Microscopy, Electron; D010431:Pentoxifylline / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D018906:Antineoplastic Agents, Alkylating; D003520:Cyclophosphamide; D010431:Pentoxifylline