title: A case of chronic hepatitis C with sinus bradycardia during IFN therapy.
abstract: The patient was a 55-year-old male with no history of heart diseases. He was administered recombinant IFN alpha-2b under the diagnosis of chronic hepatitis C. Since sinus bradycardia (heart rate 40 bpm) appeared in the fourth week of administration (cumulative dose; 240 M.U), IFN was discontinued. Bradycardia was resolved 1 week after discontinuation of IFN, and the treatment was resumed with a change of the regimen to IFN-beta. Since no bradycardia was noted thereafter, IFN therapy could be completed (total dose; 108 M.U). These observations suggest that the type of IFN or total dose contributed to the appearance of cardiotoxicity.
authors.affiliation: Second Department of Medicine, Kurume University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Sasaki
authors.forename: M
authors.initials: M
authors.lastname: Sata
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Tanikawa
mesh_terms: D001146:Arrhythmia, Sinus / Q000139:chemically induced*; D001919:Bradycardia / Q000139:chemically induced*; D019698:Hepatitis C, Chronic / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins