title: Synthesis and cytotoxic activity of N-substituted thiosemicarbazones of 3-(3,4-methylenedioxy)phenylpropanal.
abstract: Five new N-substituted thiosemicarbazones of 3-(3,4-methylenedioxy)phenylpropanal were synthesized. Safrole, a natural product obtained from sassafras oil (Ocotea pretiosa), was oxidized to alcohol using BH3-THF and H2O2, followed by oxidation to aldehyde using pyridinium dichromate (PDC) and condensation with five N-substituted derivatives of thiosemicarbazide. Tests were performed to evaluate the cytotoxic activity with continuous chain KB cells (epidermoide carcinoma of the floor of the mouth). Compounds 5 and 6 showed IC50 values of 1.5 and 4.6 micrograms/ml, respectively.
authors.affiliation: Laboratório de Tecnologia Química-Farmacêutica, Departamento de Farmácia-UFPE, Recife, Brazil.
authors.forename: M
authors.initials: M
authors.lastname: Joselice e Silva
authors.forename: A J
authors.initials: AJ
authors.lastname: Alves
authors.forename: S C
authors.initials: SC
authors.lastname: Do Nascimento
mesh_terms: D002460:Cell Line; D015394:Molecular Structure; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000633:toxicity
chemical_list: D013882:Thiosemicarbazones