[Epinephrine Bitartrate Reference Standard (Control 951) of National Institute of Health Sciences].
The raw material for epinephrine bitartrate was tested for preparation of the "Epinephrine Bitartrate Reference Standard (Control 951)" of National Institute of Health Sciences. Analytical data obtained were as follows: melting point, 148.6 degrees C (decomposition); UV spectrum, lambda max = 279 nm; IR spectrum, the same as that of JP Epinephrine Bitartrate Reference Standard (Control 792); optical rotation, [alpha]20D = -52.8 degrees; thin-layer chromatography, one impurity was detected; high-performance liquid chromatography, no impurity was detected; loss on drying, 0.01%; assay, 99.6% by potentiometric titration, 100.3% by spectrophotometry. Based on the above results, the raw material was authorized as the Epinephrine Bitartrate Reference Standard (Control 951) of National Institute of Health Sciences (Japanese Pharmacopoeia).
Kitajima
A
A
Tagashira
Y
Y
Maekawa
K
K
Yoshii
K
K
Komatsu
H
H
Tanimoto
T
T
Okada
S
S
D004837:Epinephrine / Q000592:standards*; D007564:Japan; D012015:Reference Standards
D004837:Epinephrine