Levels of troponin I and cardiac enzymes after reinfusion of shed blood in coronary operations.
BACKGROUND
Reinfusion of shed blood after coronary artery bypass grafting might increase the levels of cardiac enzymes with consequent difficulties in the diagnosis of perioperative myocardial infarction.


METHODS
Thirty consecutive patients undergoing coronary artery bypass grafting who bled at least 400 mL within the first 4 hours after operation underwent reinfusion of shed blood. Thirty consecutive patients who were not autotransfused served as control. All patients underwent enzyme determination (total creatine kinase, MB fraction, lactate dehydrogenase, and troponin I) in the shed blood and in circulating blood preoperatively, at arrival in the intensive care unit, and 6, 24, and 48 hours after operation.


RESULTS
The shed blood contained significantly higher concentration of cardiac enzymes than the circulating blood at all time intervals (p = 0.0001). The levels of creatine kinase, its MB fraction, and lactate dehydrogenase in circulating blood were significantly elevated in patients receiving autotransfusion up to 24 hours after autotransfusion. The blood levels of troponin I were not significantly different between the two group of patients at all time points. The percent fraction of MB did not increase after autotransfusion.


CONCLUSIONS
The measurement of cardiac troponin I is a useful marker for the diagnosis of perioperative myocardial infarction in patients undergoing transfusion of shed blood after coronary operation.
De Paulis
R
R
Cattedra di Cardiochirurgia, Università di Roma Tor Vergata, Italy.
Colagrande
L
L
Seddio
F
F
Piciché
M
M
Penta de Peppo
A
A
Bassano
C
C
Tomai
F
F
Chiariello
L
L
D015415:Biomarkers / Q000097:blood; D016063:Blood Loss, Surgical; D001804:Blood Transfusion, Autologous; D001026:Coronary Artery Bypass; D003402:Creatine Kinase / Q000097:blood*; D003422:Critical Care; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology; D019210:Troponin I / Q000097:blood*
D015415:Biomarkers; D007527:Isoenzymes; D019210:Troponin I; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase