[A study of LOH on chromosome 9p21 region D9S319 locus of laryngeal carcinoma].
Loss of Heterozygosity (LOH) on chromosome 9p21 (D9S319) from fifty-four laryngeal cancer patients has been examined by using the PCR technique of DNA microsatellite markers in this study. The results showed that the LOH on 9p21 was 100% present (2/2) in in situ carcinomas and 66% (29/44) in invasive carcinomas. Therefore, these results suggest that there is a tumor suppressor gene located on 9p21 region. Its inactivation was related to laryngeal carcinoma and it was an early event.
Bai
S
S
1st Hospital of China Medical University, Shengyang.
Zhang
X
X
Wang
Y
Y
D002278:Carcinoma in Situ / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics; D002899:Chromosomes, Human, Pair 9; D016147:Genes, Tumor Suppressor; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics*; D019656:Loss of Heterozygosity