title: Prognosis value of the expression of Ki-67 for squamous cell carcinoma of the oral cavity.
abstract: Ki-67 is a nuclear antigen expressed in G1, S, G2 and M phase of cell cycle and absent in quiescent cells (G0). In some neoplasms, Ki-67 expression has a prognostic value. The purpose of this study was to determine the role of Ki-67 expression like prognostic factor in oral squamous cell carcinoma (OSCC). Monoclonal antibody MIB-1 that recognizes Ki-67 antigen was used. 74 OSCCs were analyzed. 49% of OSCCs did not express Ki-67 antigen. In the Ki-67 positive tumours, the expression was slight in 36.5%, moderate in 10.8% and intense in 10.8% of the cases. In all the positive OSCCs, the distribution of the marking was patchy in different zones of the tumour, moreover, in 65% of the lesions, the positive cells were located mainly in the proximity of intraoral blood vessels. A significantly more intense expression was noted on tumours that had not been differentiated (p < 0.05), with a larger nuclear pleomorphism (p < 0.05) and in lesions that invaded in the form of disassociated neoplastic cells of in small groups of neoplastic cells (p < 0.001). However, the expression of Ki-67 did not correlate with the mitosis count and it had no influence on survival.
authors.affiliation: Department of Oral Medicine, School of Dentistry, University of Granada, Spain.
authors.forename: M A
authors.initials: MA
authors.lastname: Gonzalez-Moles
authors.forename: R
authors.initials: R
authors.lastname: Caballero
authors.forename: A
authors.initials: A
authors.lastname: Rodriguez-Archilla
authors.forename: I
authors.initials: I
authors.lastname: Ruiz-Avila
authors.forename: I
authors.initials: I
authors.lastname: Bravo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000235:genetics; D001808:Blood Vessels / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy*; D002454:Cell Differentiation; D002467:Cell Nucleus / Q000648:ultrastructure; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis* / Q000235:genetics; D008048:Lip Neoplasms / Q000473:pathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D008938:Mitosis; D009055:Mouth / Q000098:blood supply; D009062:Mouth Neoplasms / Q000473:pathology / Q000628:therapy*; D009361:Neoplasm Invasiveness; D011379:Prognosis; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen