title: Allele frequency distributions of the polymorphic STR loci HUMVWA, HUMFES, HUMF13A01 and the VNTR D1S80 in a Filipino population from Metro Manila.
abstract: Allele frequency distributions at the short tandem repeat (STR) loci HUMVWA, HUMFES, HUMF13A01 and of the variable number of tandem repeat (VNTR) locus D1S80 were determined in a Filipino population from Metro Manila (103 individuals) by use of the polymerase chain reaction (PCR) followed by polyacrylamide gel electrophoresis (PAGE). The exact test demonstrated that all four loci had no deviations from Hardy-Weinberg equilibrium (HWE) with the only reservation that the exact test p-value for F13A01 is weak. The discriminating power is 0.82 for D1S80, and the expected exclusion chance is 0.85 for F13A01, 0.83 for FES, and 0.93 for VWA. The observed heterozygosity rates are 0.63 for D1S80, 0.66 for F13A01, 0.67 for FES, and 0.80 for VWA. The exact test for independance between all loci gave a p-value of 0.0195. This is the first time that Filipino population data of DNA loci of forensic importance are reported.
authors.affiliation: Molecular Biology & Biotechnology Program, Albert Hall, University of the Philippines, Quezon City, Metro Manila, Philippines.
authors.forename: S C
authors.initials: SC
authors.lastname: Halos
authors.forename: E S
authors.initials: ES
authors.lastname: Fortuno
authors.forename: A C
authors.initials: AC
authors.lastname: Ferreon
authors.forename: J Y
authors.initials: JY
authors.lastname: Chu
authors.forename: J
authors.initials: J
authors.lastname: Miranda
authors.forename: S
authors.initials: S
authors.lastname: Harada
authors.forename: M
authors.initials: M
authors.lastname: Benecke
mesh_terms: D000483:Alleles; D001779:Blood Coagulation Factors / Q000235:genetics; D005787:Gene Frequency / Q000235:genetics*; D005828:Genetics, Population; D006801:Humans; D018598:Minisatellite Repeats / Q000235:genetics*; D010679:Philippines; D011110:Polymorphism, Genetic / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics; D014841:von Willebrand Factor / Q000235:genetics
chemical_list: D001779:Blood Coagulation Factors; D011518:Proto-Oncogene Proteins; D014841:von Willebrand Factor