Time course of apoptosis in collagen-induced arthritis.
Recently, apoptotic cells were discovered in the synovial cells of rheumatoid arthritis patients. Their role, however, is unknown. We thus examined the time course of apoptosis in the synovium using an animal model of rheumatoid arthritis, in which arthritis was induced by intracutaneous injection of collagen. No apoptotic cells were detected before the onset of synovitis, but they increased in parallel with the progress of arthritis in its initial period, and decreased in the later chronic stages. Apoptotic cells appear to maintain the homeostasis of a joint when synovial proliferation occurs.
Morita
I
I
Department of Orthopedic Surgery, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan. matsuno@ms.Toyama-mpu.ac.jp
Matsuno
H
H
Sakai
K
K
Nezuka
T
T
Tsuji
H
H
Shirai
T
T
Nishioka
K
K
D000818:Animals; D017209:Apoptosis / Q000276:immunology; D001168:Arthritis / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D001710:Biotin / Q000378:metabolism; D003094:Collagen / Q000008:administration & dosage / Q000276:immunology*; D004253:DNA Nucleotidylexotransferase / Q000378:metabolism; D003856:Deoxyuracil Nucleotides / Q000378:metabolism; D004195:Disease Models, Animal; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D013583:Synovial Membrane / Q000473:pathology / Q000648:ultrastructure; D013997:Time Factors
D003856:Deoxyuracil Nucleotides; C027078:deoxyuridine triphosphate; D001710:Biotin; D003094:Collagen; D004253:DNA Nucleotidylexotransferase