Oesophageal narrowing in chronic granulomatous disease.
A 14 year-old boy with X-linked chronic granulomatous disease (CGD) developed a long smooth narrowing at the mid oesophagus with severe dysphagia. Endoscopy revealed a normal mucosa and biopsy showed non-specific acute inflammatory changes. Bacterial cultures of the biopsy specimens were sterile. Combined treatment with antibiotics and steroids resulted in a transitory remission, but symptoms recurred after 2.5 months. One second course of steroids and antibiotics lead to a long-term remission. Oesophagogram was more useful than endoscopy to evaluate the severity of the stricture.
Ruiz-Contreras
J
J
Department of Pediatrics, Hospital Universitario 12 de Octubre, Madrid, Spain. jruiz@h12o.es
Bastero
R
R
Serrano
C
C
Benavent
M I
MI
Martinez
A
A
D000293:Adolescent; D000900:Anti-Bacterial Agents; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D004940:Esophageal Stenosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D008040:Genetic Linkage; D005938:Glucocorticoids / Q000627:therapeutic use; D006105:Granulomatous Disease, Chronic / Q000150:complications* / Q000235:genetics; D006801:Humans; D008297:Male; D011859:Radiography; D012008:Recurrence; D014960:X Chromosome
D000900:Anti-Bacterial Agents; D005938:Glucocorticoids