Telomeres: moonlighting by DNA repair proteins.
Chromosome ends, or telomeres, are dynamic DNA structures maintained by a multisubunit telomerase and other proteins. New evidence indicates that proteins previously implicated in the repair of DNA doublestrand breaks also play an important role in the control of telomere organization and length.
Weaver
D T
DT
Center for Blood Research, Harvard Medical School, Boston, Massachusetts 02115, USA. dweaver@cbr.med.harvard.edu
D000818:Animals; D004249:DNA Damage; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000378:metabolism; D008957:Models, Genetic; D012441:Saccharomyces cerevisiae / Q000235:genetics; D019098:Telomerase / Q000378:metabolism; D016615:Telomere / Q000235:genetics* / Q000648:ultrastructure; D014158:Transcription, Genetic
D004268:DNA-Binding Proteins; D019098:Telomerase