Small-molecule-based strategies for controlling gene expression.
A central goal in chemical biology is to gain control over biological pathways using small molecules, and the mRNA-synthesizing machinery is a particular important target. New advances in our understanding of transcriptional regulation suggests strategies to manipulate these pathways using small molecules.
Denison
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Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-8573, USA.
Kodadek
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T
D000818:Animals; D015195:Drug Design; D005786:Gene Expression Regulation; D005818:Genetic Engineering / Q000379:methods*; D006801:Humans; D008957:Models, Genetic; D008958:Models, Molecular; D012333:RNA, Messenger / Q000096:biosynthesis*
D012333:RNA, Messenger