title: Humoral immune and clinical responses to food antigens following acute diarrhoea in children.
abstract: OBJECTIVE
  To investigate the effect of acute watery diarrhoea in children upon humoral immune responses to food antigens and the subsequent development of food allergy.
  
  
  METHODS
  Serum antibodies to cows' milk, beta-lactoglobulin, alpha-lactalbumin, bovine serum albumin and ovalbumin were measured in 30 children with acute diarrhoea in the acute phase and 1 month after recovery. The children were followed for 1 year to assess the development of food allergy.
  
  
  RESULTS
  IgG antibeta-lactoglobulin titres for the study group increased 1 month after recovery compared to the titres during the acute phase (P = 0.02). Antibody concentration for the other antigens studied did not rise. Four children developed positive IgE antibodies to one or more of the allergens after the diarrhoeal episode, although the titres were very low. None showed evidence of allergy to cows' milk or egg during the year-long follow-up.
  
  
  CONCLUSIONS
  Acute diarrhoea in children resulted in increased production of IgG antibody to beta-lactoglobulin and had a priming effect for development of positive IgE antibody to cows' milk. Clinical food allergy was not observed in any of the children during the year-long follow-up.
authors.affiliation: International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
authors.forename: T
authors.initials: T
authors.lastname: Ahmed
authors.forename: R
authors.initials: R
authors.lastname: Sumazaki
authors.forename: K
authors.initials: K
authors.lastname: Shin
authors.forename: Y
authors.initials: Y
authors.lastname: Nagai
authors.forename: M
authors.initials: M
authors.lastname: Shibasaki
authors.forename: G J
authors.initials: GJ
authors.lastname: Fuchs
authors.forename: H
authors.initials: H
authors.lastname: Takita
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology*; D002417:Cattle; D002675:Child, Preschool; D003968:Diarrhea, Infantile / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007768:Lactalbumin / Q000276:immunology; D007782:Lactoglobulins / Q000276:immunology; D008297:Male; D008892:Milk / Q000276:immunology; D016269:Milk Hypersensitivity / Q000276:immunology*; D010047:Ovalbumin / Q000276:immunology; D012307:Risk Factors; D012400:Rotavirus Infections / Q000276:immunology; D012710:Serum Albumin, Bovine / Q000276:immunology
chemical_list: D000941:Antigens; D007782:Lactoglobulins; D012710:Serum Albumin, Bovine; D010047:Ovalbumin; D007768:Lactalbumin