[The mechanisms of progesterone treatment on endometrial carcinoma].
OBJECTIVE
To study the mechanisms of the exogenic progestrerone treatment on endometrial carcinoma.


METHODS
We observed the morphologic changes of the endometrial cancer cells treated by exogenic progesterone with light and electronic microscopy.


RESULTS
The main changes of the tumor cell treated were well differentiation, increase in secretory activity and apoptosis of tumor cells.


CONCLUSIONS
Progesterone may directly affect tumor cells, inhibit the growth of tumor cells and lead to well differentiation. Clinically with preoperative and postoperative progesterone therapy, it can decrease the peritoneum implantation and metastasis, and also decrease the recurrence after operation.
Chen
C
C
Shanghai Ruijin Hospital.
Hua
Z
Z
Jin
X
X
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000648:ultrastructure; D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D016889:Endometrial Neoplasms / Q000188:drug therapy* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D006908:Hydroxyprogesterones / Q000627:therapeutic use*; D008875:Middle Aged
D018931:Antineoplastic Agents, Hormonal; D006908:Hydroxyprogesterones