Borna disease in a dog with lethal meningoencephalitis.
A dog was euthanatized because of progressive neurological signs. Histologically, a nonsuppurative meningoencephalitis was found. By immunohistochemistry, in situ hybridization, and nested PCR procedures, Borna disease virus (BDV) antigen and BDV-specific RNA were demonstrated in brain tissues of the dog. The nucleotide sequence of the PCR product showed 94 to 98% homology to published BDV sequences. This is the first description of Borna disease in a dog.
Weissenböck
H
H
Institute of Pathology and Forensic Veterinary Medicine, University of Veterinary Medicine, Vienna, Austria. Herbert.Weissenboeck@vu-wien.ac.at
Nowotny
N
N
Caplazi
P
P
Kolodziejek
J
J
Ehrensperger
F
F
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D001483:Base Sequence; D001890:Borna Disease / Q000821:virology*; D001891:Borna disease virus / Q000145:classification / Q000302:isolation & purification*; D001921:Brain / Q000648:ultrastructure / Q000821:virology; D004283:Dog Diseases / Q000821:virology*; D004285:Dogs; D005260:Female; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008590:Meningoencephalitis / Q000662:veterinary* / Q000821:virology; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction / Q000379:methods; D012367:RNA, Viral / Q000032:analysis
D000956:Antigens, Viral; D012367:RNA, Viral