title: Resection and graft repair for localized hypertrophic neuropathy.
abstract: OBJECTIVE
  Formulation of surgical management recommendations for localized hypertrophic mononeuropathy has been difficult because of the infrequency of the lesion, lack of precise pathological diagnosis, and uncertainties regarding its cause. The purpose of this retrospective review of the Louisiana State University (LSU) experience with this unusual neuropathy was to evaluate the efficacy of lesion resection and interposition grafting in its management.
  
  
  METHODS
  The charts of 15 patients operated on at LSU during a 15-year period with a pathological diagnosis of localized hypertrophic neuropathy were reviewed.
  
  
  RESULTS
  Hypertrophic lesions were located on major named peripheral nerves of the extremities, distributed equally to the upper and lower extremities. Family history was negative for all patients, and entrapment or trauma, other than previous surgery, were unlikely by symptom location or history. Weakness was the most common presentation. The mean length of symptoms was 76 months. Atrophy, sensory loss, Tinel's sign, focal tenderness, and a mass were found in the majority of patients. Preoperative electrophysiological studies showed chronic denervational changes in all patients. At surgery, if no action potential or one of low amplitude was recorded across the lesion, the lesion was resected and an autologous nerve graft measuring from 3.5 to 8.5 cm in length was interposed. During follow-up periods of 1 or more years, seven of nine patients with localized hypertrophic mononeuropathy treated with graft repairs were either unchanged or improved.
  
  
  CONCLUSIONS
  Localized hypertrophic mononeuropathy is a progressive process associated with pathological nerve changes that correlate with eventual severe functional loss. If intraoperative histological examination shows onion bulb neuropathy and intraoperative nerve action potentials confirm a nonfunctioning or poorly functioning segment, lesion resection with interposition graft repair provides the possibility of some degree of recovery.
authors.affiliation: Department of Neurological Surgery, School of Medicine, University of Southern California, Los Angeles 90033, USA.
authors.forename: J P
authors.initials: JP
authors.lastname: Gruen
authors.forename: W
authors.initials: W
authors.lastname: Mitchell
authors.forename: D G
authors.initials: DG
authors.lastname: Kline
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000293:Adolescent; D000328:Adult; D001132:Arm / Q000294:innervation; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006984:Hypertrophy; D007866:Leg / Q000294:innervation; D008297:Male; D009416:Nerve Regeneration / Q000502:physiology; D010525:Peripheral Nerves / Q000637:transplantation*; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D011183:Postoperative Complications / Q000175:diagnosis / Q000503:physiopathology; D012189:Retrospective Studies; D016896:Treatment Outcome