title: [A new parameter for the evaluation of premature luteinization: the pre-ovulatory molecular relation between serum concentrations of progesterone and estradiol].
abstract: The objective was to evaluate the molecular ratio between the serum levels of progesterone (P) and estradiol (E2) and to determine it's effect on the in vitro fertilization performance. Sixty two couples were studied, the molecular P:E2 ratio was established the day of human chorionic gonadotropin (hCG) injection. The mean serum P concentration the day of hCG administration 1.45 +/- 0.50 ng/mL, while the mean P:E2 ratio was 0.63 +/- 0. Pregnancies were observed since molecular ration of 0.22, no pregnancies were obtained if the molecular ratio was > 1.02. No significant difference was detected in the fertilization and pregnancy rates in the patients who have or not premature luteinization. The implantation rate was low in patients with premature luteinization, however, there was not significant difference with patients without premature luteinization. In conclusion, the P:E2 ratio surrounding 1.0 is desirable to obtain adequate results in in vitro fertilization programs. In this work as others, the premature luteinization do not have effect in the reproductive results.
authors.affiliation: Clínica de Infertilidad, Endoscopía y Embarazo de Alto Riesgo, México, D.F.
authors.forename: A
authors.initials: A
authors.lastname: Kably Ambe
authors.forename: G
authors.initials: G
authors.lastname: Méndez Espinosa
authors.forename: J
authors.initials: J
authors.lastname: Barrón Vallejo
mesh_terms: D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000008:administration & dosage*; D004958:Estradiol / Q000097:blood*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007246:Infertility; D007986:Luteinizing Hormone / Q000378:metabolism*; D016471:Ovarian Hyperstimulation Syndrome / Q000209:etiology; D011247:Pregnancy; D011374:Progesterone / Q000097:blood*
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone
vernacular_title: "Un nuevo parámetro para evaluar la luteinización prematura: la relación molecular preovulatoria entre las concentraciones séricas de progesterona y estradiol".