title: [Hemophagocytic syndrome due to miliary tuberculosis in the course of aplastic anemia].
abstract: We report a 63 year-old female with aplastic anemia (AA) who was complicated with hemophagocytic syndrome induced by systemic miliary tuberculosis. Two years before admission to our hospital, she was diagnosed as AA and had been treated with granulocyte colony-stimulating factor, erythropoietin and methenolone acetate. In May, 1996, She was transferred to our hospital because of high fever and exacervation of pancytopenia. She showed severe pancytopenia, and an increase in macrophages showing remarkable erythrophagocytosis and decrease in hemopoietic cells in the bone marrow. In initial examination, high titer of IgM antibody to herpes simplex virus type I was identified and methylprednisolone pulse therapy was started under the diagnosis of virus associated hemophagocytic syndrome. Ten days later, however, she died for intestinal hemorrhage followed by multiorgan failure. In autopsy, multiple epitheloid cell granulomas with acid-fast bacilli were found in bone marrow, lungs, liver, spleen and kidneys.
authors.affiliation: Hematology Division, School of Medicine Iwate Medical University.
authors.forename: A
authors.initials: A
authors.lastname: Yashima
authors.forename: Y
authors.initials: Y
authors.lastname: Narigasawa
authors.forename: Y
authors.initials: Y
authors.lastname: Ishida
authors.forename: T
authors.initials: T
authors.lastname: Uchiyama
authors.forename: T
authors.initials: T
authors.lastname: Oyake
authors.forename: S
authors.initials: S
authors.lastname: Enomoto
authors.forename: J
authors.initials: J
authors.lastname: Kaneko
authors.forename: Y
authors.initials: Y
authors.lastname: Ono
authors.forename: T
authors.initials: T
authors.lastname: Sugawara
authors.forename: H
authors.initials: H
authors.lastname: Numaoka
authors.forename: K
authors.initials: K
authors.lastname: Shimosegawa
authors.forename: K
authors.initials: K
authors.lastname: Murai
authors.forename: S
authors.initials: S
authors.lastname: Itoh
authors.forename: T
authors.initials: T
authors.lastname: Ito
authors.forename: S
authors.initials: S
authors.lastname: Kuriya
mesh_terms: D000741:Anemia, Aplastic / Q000150:complications*; D005260:Female; D015616:Histiocytosis, Non-Langerhans-Cell / Q000209:etiology*; D006801:Humans; D016867:Immunocompromised Host; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000209:etiology; D014391:Tuberculosis, Miliary / Q000150:complications*