title: Magnetic field exposure and neurodegenerative disease mortality among electric utility workers.
abstract: Several recent reports indicate that occupational exposure to electric and magnetic fields may be associated with increased risk of neurodegenerative diseases. To address that hypothesis, we analyzed data from a cohort study of electric utility workers. We examined exposure to magnetic fields, assessed as duration of work in exposed jobs and through an index of cumulative exposure based on magnetic field measurements, in relation to mortality from Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, considering both underlying and all mentioned causes of death. Adjusted mortality rate ratios based on Poisson regression models indicate no association between magnetic fields and Parkinson's disease and little support for an association with Alzheimer's disease mortality. Mortality from amyotrophic lateral sclerosis was positively associated with duration of work in exposed jobs [rate ratio = 2.0, 95% confidence interval (CI)= 0.7-6.0; and rate ratio = 3.1, 95% CI = 1.0-9.8, based on underlying cause for 5 - < 20 years and > or = 20 years vs < 5 years, respectively], as well as with cumulative magnetic field exposure with a > or = 20-year lag (rate ratio = 2.3, 95% CI = 0.8-6.6; and rate ratio = 3.0, 95% CI = 1.0-9.2, for exposure in the middle and upper intervals relative to the lowest interval, respectively).
authors.affiliation: Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill 27599-7400 USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Savitz
authors.forename: H
authors.initials: H
authors.lastname: Checkoway
authors.forename: D P
authors.initials: DP
authors.lastname: Loomis
mesh_terms: D000328:Adult; D000544:Alzheimer Disease / Q000209:etiology / Q000401:mortality; D000690:Amyotrophic Lateral Sclerosis / Q000209:etiology / Q000401:mortality; D002423:Cause of Death; D015331:Cohort Studies; D016001:Confidence Intervals; D011211:Electric Power Supplies / Q000009:adverse effects*; D004574:Electromagnetic Fields / Q000009:adverse effects*; D006801:Humans; D008297:Male; D019636:Neurodegenerative Diseases / Q000209:etiology / Q000401:mortality*; D009784:Occupational Diseases / Q000209:etiology / Q000401:mortality*; D016273:Occupational Exposure / Q000009:adverse effects* / Q000706:statistics & numerical data; D016017:Odds Ratio; D010300:Parkinson Disease / Q000209:etiology / Q000401:mortality; D011829:Radiation Dosage; D012044:Regression Analysis; D012189:Retrospective Studies; D013997:Time Factors; D014481:United States / Q000453:epidemiology