Oral cimetidine prolongs clarithromycin absorption.
The present study was conducted to identify any potential interaction between oral cimetidine and clarithromycin. Twelve healthy subjects were administered single doses of clarithromycin alone and with oral cimetidine dosed to steady state. Cimetidine prolonged the absorption of clarithromycin, as evidenced by decreased peak concentrations of both clarithromycin and 14-OH-clarithromycin (14OHC) in serum (46 and 43%, respectively), a delay in the formation of 14OHC (increase of 68%), and increases in both of their half-lives (75 and 82%, respectively), despite no changes in total oral clearance or area under the concentration-time curve for either compound. No mechanism for this interaction has been identified.
Amsden
G W
GW
Clinical Pharmacology Research Center, Bassett Healthcare, Cooperstown, New York 13326, USA. amsden@telenet.net
Cheng
K L
KL
Peloquin
C A
CA
Nafziger
A N
AN
D000042:Absorption; D000284:Administration, Oral; D000328:Adult; D000900:Anti-Bacterial Agents / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*; D002927:Cimetidine / Q000494:pharmacology*; D017291:Clarithromycin / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*; D018592:Cross-Over Studies; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D013997:Time Factors
D000900:Anti-Bacterial Agents; D065607:Cytochrome P-450 Enzyme Inhibitors; C056228:14-hydroxyclarithromycin; D002927:Cimetidine; D003577:Cytochrome P-450 Enzyme System; D017291:Clarithromycin