title: Two (Z)-dehydrobutyrine-containing microcystins from a hepatotoxic bloom of Oscillatoria agardhii from Soulseat Loch, Scotland.
abstract: Two (Z)-dehydrobutyrine(Dhb)-containing microcystins, [d-Asp3, (Z)-Dhb7]microcystin-HtyR (1) and [d-Asp3, (Z)-Dhb7]microcystin-LR (2), were isolated from a hepatotoxic bloom of the cyanobacterium Oscillatoria agardhii from a freshwater lake in Scotland. The geometrical structure of the Dhb units in the microcystins was determined as Z on the basis of NOE and ROESY experiments.
authors.affiliation: Environmental Chemistry Division, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-0053, Japan. sanotomo@nies.go.jp
authors.forename: T
authors.initials: T
authors.lastname: Sano
authors.forename: K A
authors.initials: KA
authors.lastname: Beattie
authors.forename: G A
authors.initials: GA
authors.lastname: Codd
authors.forename: K
authors.initials: K
authors.lastname: Kaya
mesh_terms: D002240:Carbohydrate Sequence; D056486:Chemical and Drug Induced Liver Injury; D000458:Cyanobacteria / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D052998:Microcystins; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification*; D012606:Scotland; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D052998:Microcystins; D010456:Peptides, Cyclic; C113240:microcystin-HtyR, Asp(3)-Dhb(7)-; C113241:microcystin-LR, Asp(3)-Dhb(7)-