Stiffness indexes beta of the common carotid and femoral arteries are associated with insulin resistance in NIDDM.
OBJECTIVE
To investigate the association between arterial wall stiffness indexes beta of the common carotid artery (CCA) and the femoral artery (FA) and insulin resistance in NIDDM subjects in a cross-sectional study.


METHODS
We evaluated the arterial stiffness indexes beta of CCA and FA using an ultrasonic phase-locked echo-tracking system in 60 NIDDM subjects attending the diabetes center in Osaka City University Hospital, compared with 120 age- and sex-matched control subjects. Insulin sensitivity indexes were evaluated using a euglycemic-hyperinsulinemic clamp.


RESULTS
Stiffness indexes beta of both CCA and FA were significantly higher in NIDDM subjects than in control subjects (CCA 18.1 +/- 0.9 vs. 11.7 +/- 0.3, respectively, P < 0.001; FA 35.7 +/- 2.3 vs. 23.7 +/- 0.8, respectively, P < 0.001). The mean insulin sensitivity index in NIDDM subjects was 4.69 +/- 0.29 mg.kg-1.min-1.mU-1.l. The stiffness indexes beta of both CCA and FA were inversely correlated with insulin sensitivity indexes (CCA r = -0.393, P = 0.002; FA r = -0.329, P = 0.010), as well as with age, duration of diabetes, and mean blood pressure. In stepwise multiple regression analyses, insulin sensitivity index and duration of diabetes were identified as significant independent variables for stiffness indexes beta in both CCA and FA (CCA R2 = 0.249, P = 0.0003; FA R2 = 0.336, P < 0.001).


CONCLUSIONS
Arterial stiffness indexes beta of CCA and FA were associated with insulin resistance in NIDDM subjects.
Emoto
M
M
Second Department of Internal Medicine, Osaka City University Medical School, Japan.
Nishizawa
Y
Y
Kawagishi
T
T
Maekawa
K
K
Hiura
Y
Y
Kanda
H
H
Izumotani
K
K
Shoji
T
T
Ishimura
E
E
Inaba
M
M
Okuno
Y
Y
Morii
H
H
D000328:Adult; D000367:Age Factors; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D017536:Carotid Artery, Common / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D004548:Elasticity; D005260:Female; D005263:Femoral Artery / Q000503:physiopathology*; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis
D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin