The effect of forskolin on the sound-evoked potentials in the guinea pig cochlea.
The effect of forskolin (FSK) on cochlear sound-evoked potentials was examined in the guinea pig. The perfusion of the scala vestibuli (SV) with FSK (2 x 10(-4) M) produced a significant increase in the amplitude of negative summating potential (- SP) with no change in cochlear microphonics (CM) amplitude, and a significant decrease in the amplitude of compound action potential (CAP) with a significant prolongation of N1 latency and a 20 dB CAP threshold elevation. The results lead us to speculate that FSK-induced changes may be involved in the transient formation of endolymphatic hydrops.
Kitano
I
I
Department of Otolaryngology, Nara Medical University, Kashihara City, Japan.
Mori
N
N
Nario
K
K
Doi
K
K
Matsunaga
T
T
D000818:Animals; D003051:Cochlea / Q000187:drug effects* / Q000502:physiology; D003055:Cochlear Microphonic Potentials / Q000187:drug effects* / Q000502:physiology; D005576:Colforsin / Q000494:pharmacology*; D018159:Endolymphatic Hydrops / Q000209:etiology; D006168:Guinea Pigs; D017136:Ion Transport
D005576:Colforsin