title: The expression in vivo of a second isoform of pT alpha: implications for the mechanism of pT alpha action.
abstract: A second isoform of pT alpha, "pT alpha(b)," is derived from the pT alpha locus by tissue-specific, alternative splicing. pT alpha(b) is coexpressed in the thymus with the previously characterized form of pT alpha (which we term pT alpha(a)) and is also expressed in peripheral cells without pT alpha(a). While pT alpha(a) acts to retain most TCR beta-chains intracellularly, pT alpha(b) permits higher levels of cell surface TCR beta expression and facilitates signaling from a CD3-TCR beta complex.
authors.affiliation: Department of Molecular, Cell & Developmental Biology, Yale University, New Haven, CT 06520, USA.
authors.forename: D F
authors.initials: DF
authors.lastname: Barber
authors.forename: L
authors.initials: L
authors.lastname: Passoni
authors.forename: L
authors.initials: L
authors.lastname: Wen
authors.forename: L
authors.initials: L
authors.lastname: Geng
authors.forename: A C
authors.initials: AC
authors.lastname: Hayday
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D002469:Cell Separation; D002999:Clone Cells; D007536:Isomerism; D008213:Lymphocyte Activation / Q000235:genetics; D008562:Membrane Glycoproteins / Q000096:biosynthesis* / Q000235:genetics / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D012333:RNA, Messenger / Q000096:biosynthesis; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000096:biosynthesis* / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism
chemical_list: D008562:Membrane Glycoproteins; D012333:RNA, Messenger; D016693:Receptors, Antigen, T-Cell, alpha-beta; C090377:pre-T cell receptor alpha