[Comparative efficacy, safety, cardio-hemodynamic effects of isosorbide dinitrate (ID) aerosol and sublingual tablets of nitroglycerin].
OBJECTIVE
To study efficacy, safety, cardiohemodynamic effects of ID aerosol--isoket--for relief of anginal attacks and their prevention in long-term treatment.


METHODS
15 patients with ischemic heart disease suffering from stable angina class II-III. Isoket was tried for efficacy, tolerance, hemodynamic parameters, morphofunctional status of the heart, exercise tolerance.


RESULTS
Isoket aerosol in a dose 1.25 mg as a single oral spray arrested anginal attacks in all the patients. In long-term regimens good antianginal effect was achieved in 60% of cases. The ID aerosol produces a fast antianginal effect, improves morphofunctional cardiac parameters and exercise tolerance.


CONCLUSIONS
Isoket spray is effective and safe antianginal drug.
Ol'binskaia
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Ushakova
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D000280:Administration, Inhalation; D000286:Administration, Sublingual; D000336:Aerosols; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy* / Q000503:physiopathology / Q000517:prevention & control; D004562:Electrocardiography; D017079:Exercise Tolerance; D005260:Female; D005500:Follow-Up Studies; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000008:administration & dosage* / Q000627:therapeutic use; D012449:Safety; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000627:therapeutic use
D000336:Aerosols; D014665:Vasodilator Agents; D005996:Nitroglycerin; D007548:Isosorbide Dinitrate
Sravnitel'naia éffektivnost', bezopasnost', kardiogemodinamicheskie éffekty aérozolia izosorbida dinitrata i sublingval'nykh tabletok nitroglitserina.