Accelerated laser resurfacing wound healing using a triad of topical antioxidants.
BACKGROUND
The speed of wound healing and the duration of erythema are the primary complaints after laser skin resurfacing. Antioxidants have been shown to enhance the healing of wounds by reducing free radical damage. Reepithelialization is also enhanced by the moist environment produced by occlusive dressings.


OBJECTIVE
This study was conducted to compare two occlusive agents: white petrolatum and "melting" petrolatum. Another arm of the study evaluated the use of melting petrolatum with and without a triad of topical antioxidants (TTA).


RESULTS
Plain white petrolatum proved superior to melting petrolatum in time required for reepithelialization as well as in discomfort. Crusting and pain were decreased with white petrolatum but duration of erythema was equivalent. Wound healing was enhanced when TTA was added. Time for reepithelialization, duration of crusting and scabbing, pain, redness, and swelling were decreased when TTA was added to topical therapy.


CONCLUSIONS
TTA compound enhances and hastens wound healing. White petrolatum as a base occlusive vehicle shortens reepithelialization compared with "melting" petrolatum.
McDaniel
D H
DH
Laser Center of Virginia, Virginia Beach 23454-3101, USA.
Ash
K
K
Lord
J
J
Newman
J
J
Zukowski
M
M
D000279:Administration, Cutaneous; D000328:Adult; D000975:Antioxidants / Q000627:therapeutic use*; D062109:Dermatologic Surgical Procedures; D004643:Emollients / Q000627:therapeutic use; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010577:Petrolatum / Q000627:therapeutic use; D012867:Skin / Q000503:physiopathology; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*
D000975:Antioxidants; D004643:Emollients; D010577:Petrolatum