Imidazoline receptor proteins in brains of patients with Alzheimer's disease.
Imidazoline receptors (29/30- and 45-kDa proteins) were quantitated in postmortem brains of patients with Alzheimer's disease (AD) by using immunoblotting techniques and a specific antiserum. Increased levels of the 29/30-kDa protein (30%), 45-kDa protein (36%) and glial fibrillary acidic protein (88%) were found in the frontal cortex of AD patients. These findings are in line with the reported higher density of imidazoline receptors labelled by [3H]idazoxan in AD brains, suggesting that these imidazoline receptor proteins are related to the I2-imidazoline receptor located in mitochondria of glial (astrocyte) cells.
García-Sevilla
J A
JA
Department of Psychiatry, Faculty of Medicine, University of Geneva, H.U.G., Chêne-Bourg, Switzerland.
Escribá
P V
PV
Walzer
C
C
Bouras
C
C
Guimón
J
J
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D001253:Astrocytes / Q000737:chemistry; D001284:Atrophy; D015415:Biomarkers / Q000032:analysis; D005260:Female; D005625:Frontal Lobe / Q000737:chemistry* / Q000473:pathology; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006801:Humans; D054755:Imidazoline Receptors; D008297:Male; D009419:Nerve Tissue Proteins / Q000032:analysis*; D011942:Receptors, Adrenergic, alpha / Q000032:analysis*; D011955:Receptors, Drug / Q000032:analysis*
D015415:Biomarkers; D005904:Glial Fibrillary Acidic Protein; D054755:Imidazoline Receptors; D009419:Nerve Tissue Proteins; D011942:Receptors, Adrenergic, alpha; D011955:Receptors, Drug; C064580:idazoxan receptor