[Combined thrombolysis by pharmacokinetically different plasminogen activators].
Prospects for the search for thrombolytic compositions on the basis of short-term and long-term acting plasminogen activators were shown. These will be useful as potential ambulance remedies for effective prehospital treatment. Combined proteolysis by plasminogen activators with complementary action mechanisms and significantly different pharmacokinetic behavior was suggested for this purpose.
Maksimenko
A V
AV
Institute of Experimental Cardiology, Ministry of Health and Medical Industry of the Russian Federation, Moscow, Russia. csc@adonis.ias.msk.su
D000818:Animals; D004285:Dogs; D004338:Drug Combinations; D005340:Fibrinogen / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D005342:Fibrinolysis / Q000187:drug effects; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D007262:Infusions, Intravenous; D013924:Thrombophlebitis / Q000097:blood / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*
D004338:Drug Combinations; D005343:Fibrinolytic Agents; C114398:urokinase-fibrinogen conjugate; D005340:Fibrinogen; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator
Sochetannyĭ trombolizis farmakokineticheski razlichnymi aktivatorami plazminogena.