title: Electrocardiographic changes during prolonged coronary artery occlusion in man: comparison of standard and high-frequency recordings.
abstract: Detection of acute myocardial ischaemia using electrocardiographic methods is generally based on assessment of the ST segments in the standard 12-lead electrocardiogram (ECG). Several studies have also shown changes in high-frequency QRS components during acute ischaemia. The purpose of the present study was to determine the changes in high-frequency QRS components during prolonged percutaneous transluminal coronary angioplasty (PTCA) and to compare these changes with ST-segment deviations in the standard 12-lead ECG. The study population consisted of 19 patients receiving prolonged PTCA. Standard and high-resolution signal-averaged ECGs were recorded before and during balloon inflation. The high-resolution recordings were performed using bipolar X, Y and Z leads. The QRS complexes in the high-resolution signal-averaged ECGs were analysed within a bandwidth of 150-250 Hz. During inflation, significant reductions in high-frequency QRS components were observed (12-72%). Changes in the high-frequency QRS components were seen in four of the patients without ST-segments deviation in the standard ECG. The correlation between the ST-segment deviation and the reduction in high-frequency QRS components was weak (r = 0.27). Acute coronary artery occlusion produces changes in high-frequency QRS components, even in the absence of ST-segment deviation in the standard ECG. Further studies need to be carried out to evaluate whether analysis of high-frequency QRS components could provide a method for detecting myocardial ischaemia and give additional information to that available in the ST segment in the standard ECG.
authors.affiliation: Department of Clinical Physiology, Lund University, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Pettersson
authors.forename: P
authors.initials: P
authors.lastname: Lander
authors.forename: O
authors.initials: O
authors.lastname: Pahlm
authors.forename: L
authors.initials: L
authors.lastname: Sörnmo
authors.forename: S G
authors.initials: SG
authors.lastname: Warren
authors.forename: G S
authors.initials: GS
authors.lastname: Wagner
mesh_terms: D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D004562:Electrocardiography / Q000145:classification* / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000175:diagnosis* / Q000628:therapy; D012815:Signal Processing, Computer-Assisted; D013223:Statistics as Topic