title: The efficiency of CO2 elimination during high-frequency jet ventilation for laryngeal microsurgery.
abstract: For adequate and safe use of high-frequency jet ventilation (HFJV), reliable monitoring of the PCO2 status and course is necessary. Because of improved handling and performance, recently available transcutaneous PCO2 monitoring devices such as MicroGas 7650 (Kontron Instruments Medical Sensors, Basel, Switzerland) should enable more effective surveillance of CO2 elimination and, subsequently, better control of subglottic HFJV. Adult patients (n = 164) undergoing laryngeal microsurgery during total i.v. anesthesia were assessed. The resulting transcutaneous PCO2 values, as well as the necessary driving pressure settings, were analyzed to define the CO2 elimination capacity of each patient. Therefore, an individual CO2 elimination coefficient (ECCO2) was calculated. The frequency distribution of the obtained ECCO2 values showed a normal distribution with a median at 0.79 and a range between 0.30 and 2.17. A significant difference in the frequency of obstructive lung disease was found between two patient subpopulations separated by the 25th percentile at an ECCO2 value of 0.63. Other co-factors of CO2 elimination during HFJV were age, gender, and body weight, whereas height and ventilation duration were not involved. We conclude that the individual assessment of ECCO2 enables one to find adequate ventilator settings, resulting in lower airway pressure and less cooling and drying of the tracheobronchial mucosa.
  
  
  CONCLUSIONS
  CO2 elimination during high-frequency jet ventilation can be assessed by calculating the CO2 elimination coefficient (ECCO2) of each patient from the required driving pressure and the resulting transcutaneous CO2 partial pressure. The frequency distribution of ECCO2 in a typical laryngological patient population was analyzed, and a value of 0.63 was found to be a characteristic limit between sufficient and difficult CO2 elimination. The individual assessment of ECCO2 enables one to find adequate ventilator settings, resulting in lower airway pressure and less cooling and drying of the tracheobronchial mucosa.
authors.affiliation: Department of Anesthesiology, University Hospital Zurich, Switzerland. pbiro8888@aol.com
authors.forename: P
authors.initials: P
authors.lastname: Biro
authors.forename: G
authors.initials: G
authors.lastname: Eyrich
authors.forename: R G
authors.initials: RG
authors.lastname: Rohling
mesh_terms: D000328:Adult; D000368:Aged; D002245:Carbon Dioxide / Q000032:analysis*; D006611:High-Frequency Jet Ventilation / Q000379:methods*; D006801:Humans; D007830:Larynx / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000008:administration & dosage; D010313:Partial Pressure; D012189:Retrospective Studies
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen