Formulation and characterization of calcium alginate beads containing ampicillin.
The purpose of this work was the preparation and characterization of calcium alginate beads containing ampicillin. Aqueous solutions of drug and sodium alginate (three viscosity grades) were added drop by drop to aqueous solutions of calcium chloride; the droplets instantaneously formed gel beads, which were then dried. Morphological studies and drug contents, in vitro release, and erosion tests were carried out for the characterization of the prepared beads. The dried particles were characterized by irregular shape and a smooth or rough surface, depending on the viscosity grade of the alginate used. The control of the drug for different time intervals depended on the molecular weight of the polymer used; however, the pH-change test showed that this capacity was much lower in the case of acid-treated particles. The results obtained show that the ampicillin beads prepared are suitable for intramammary therapy.
Torre
M L
ML
Dipartimento di Chimica Farmaceutica, Università di Pavia, Italy.
Giunchedi
P
P
Maggi
L
L
Stefli
R
R
Machiste
E O
EO
Conte
U
U
D000464:Alginates / Q000737:chemistry*; D000667:Ampicillin / Q000737:chemistry*; D004337:Drug Carriers; D004339:Drug Compounding; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D012995:Solubility; D014783:Viscosity
D000464:Alginates; D004337:Drug Carriers; D006603:Hexuronic Acids; D000667:Ampicillin; D020723:Glucuronic Acid