title: Release of a substance that suppresses spontaneous motor activity in the brain by physical exercise.
abstract: Injection of the cerebrospinal fluid (CSF) collected from rats fatigued by obligatory swimming into the cisterna magna of mice suppressed the spontaneous motor activity of the mice. The suppressive activity was abolished by heat denaturation of the CSF and was found in the CSF fraction with a molecular weight above 10,000 after ultrafiltration. These findings suggest the presence of a substance(s) released in a fatigued animal's brain that suppresses its spontaneous motor activity and generates the sensation of fatigue.
authors.affiliation: Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Inoue
authors.forename: H
authors.initials: H
authors.lastname: Yamazaki
authors.forename: Y
authors.initials: Y
authors.lastname: Manabe
authors.forename: C
authors.initials: C
authors.lastname: Fukuda
authors.forename: T
authors.initials: T
authors.lastname: Fushiki
mesh_terms: D000818:Animals; D015306:Biogenic Monoamines / Q000134:cerebrospinal fluid; D001923:Brain Chemistry / Q000502:physiology*; D002555:Cerebrospinal Fluid / Q000502:physiology*; D019344:Lactic Acid / Q000134:cerebrospinal fluid; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008970:Molecular Weight; D009043:Motor Activity / Q000502:physiology*; D018763:Muscle Fatigue / Q000502:physiology; D005082:Physical Exertion / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013550:Swimming
chemical_list: D015306:Biogenic Monoamines; D019344:Lactic Acid