The effect of dietary sulfur-containing amino acids on calcium excretion.
The relationships between dietary protein and sulfur amino acid (methionine and cystine or taurine) intakes and urinary calcium excretion were examined both in animals and in young men. Thirty-two adult Wistar rats were divided into 4 groups, i.e., basal diet (group I), supplemented with albumin (II), methionine and cystine (III), or taurine (IV). During the 5-week feeding period, food consumption was recorded and 48 h urine samples were collected 4 times for each rat. Urinary calcium, creatinine and sulfate were measured. The results showed that the calcium and sulfate excretion in rats in group II and III were significantly higher than rats in the basal diet group. In contrast, supplementing a basal diet with taurine did not increase sulfate excretion and failed to induce hypercalciuria. The same result was also observed in the study carried out in Chinese young men. An increase in protein intake from 67 g to 107 g caused an increase in urinary calcium and sulfate. Supplementation with methionine and cystine in an amount to simulate those in the high protein diet had a similar effect. Adding taurine to the diet had no effect on urinary calcium and sulfate excretion. About 60 percent of the supplemented taurine in the diet was detected in the urine.
Wang
X B
XB
Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, Beijing, P.R. China.
Zhao
X H
XH
D000328:Adult; D000818:Animals; D002118:Calcium / Q000652:urine*; D003545:Cysteine / Q000378:metabolism*; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D008297:Male; D008715:Methionine / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013455:Sulfur / Q000378:metabolism / Q000652:urine; D013654:Taurine / Q000378:metabolism*
D013654:Taurine; D013455:Sulfur; D008715:Methionine; D003545:Cysteine; D002118:Calcium