Antitussive effect of moguisteine on allergic coughs in the guinea pig.
The effect of moguisteine, a novel peripherally acting non-narcotic antitussive drug, on allergic coughs was examined in guinea pigs. Male Hartley guinea pigs were actively sensitized to ovalbumin. The number of coughs elicited over 5 min following a 2-min exposure to ovalbumin was counted. Exposure of sensitized guinea pigs to 0.5% ovalbumin aerosol induced 22.0 +/- 3.2 coughs/5 min. Moguisteine at doses of 30 and 56 mg/kg, p.o., dose-dependently and significantly suppressed the number of allergic coughs. Dihydrocodeine at doses of 30 and 56 mg/kg, p.o., dose-dependently but not significantly reduced the number of allergic coughs. These results suggest that moguisteine may be of a therapeutic benefit in reducing allergic coughs.
Kamei
J
J
Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan. kamei@hoshi.ac.jp
Morita
K
K
Kashiwazaki
T
T
Ohsawa
M
M
D000701:Analgesics, Opioid / Q000627:therapeutic use; D000818:Animals; D000996:Antitussive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003061:Codeine / Q000031:analogs & derivatives / Q000627:therapeutic use; D003371:Cough / Q000188:drug therapy* / Q000503:physiopathology; D004195:Disease Models, Animal; D006168:Guinea Pigs; D006967:Hypersensitivity / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D013844:Thiazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D053778:Thiazolidines
D000701:Analgesics, Opioid; D000996:Antitussive Agents; D013844:Thiazoles; D053778:Thiazolidines; C087933:moguisteine; C014481:dihydrocodeine; D003061:Codeine