title: Osteomyelitis of the fibula due to septic embolism: a rare complication of a graft enteric erosion. Case report.
abstract: We report the case of a 70-year-old female who experienced a graft enteric erosion (GEE) three years after a right aorto-femoral bypass. She was treated by right axillo-femoral bypass, removal of the aortic prosthesis and direct aortic suture. The duodenum was stitched up and separated from the aorta by omentoplasty. Bacteriological culture of the removed graft identified Escherichia coli and Peptostreptococcus. Antibiotic therapy consisting of Amoxicillin and Gentamycin was given for seven days. A month later this patient developed a fibula osteomyelitis due to the same germs. She was then treated by surgical excision of the infected tissues and by antibiotics: Amoxicillin, Metronidazole and Gentamycin for one month. This case of embolism into bone due to GEE is a rare complication which indisputably establishes a link between the spontaneously septic cavity of the bowel and bone tissue by way of blood via the interstices of the fabric. The prosthesis may be responsible for blood seeding infection and not only a mere victim. The prosthesis acts as a porous membrane which allows two opposite flows: the passage of blood from graft to bowel and germ migration from naturally septic bowel to blood. When a GEE is encountered, a rigorous management is required to prevent septic embolism. The precise timing of each step of the surgical procedure remains difficult to codify.
authors.affiliation: Centre Medical du Trencavel Beziers, France.
authors.forename: P M
authors.initials: PM
authors.lastname: Moreau
mesh_terms: D000368:Aged; D000714:Anastomosis, Surgical / Q000009:adverse effects; D000900:Anti-Bacterial Agents; D001012:Aorta, Abdominal / Q000601:surgery; D016470:Bacteremia / Q000150:complications* / Q000188:drug therapy; D001807:Blood Vessel Prosthesis / Q000009:adverse effects* / Q000382:microbiology; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D004617:Embolism / Q000150:complications*; D004926:Escherichia coli / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000150:complications / Q000188:drug therapy; D005260:Female; D005263:Femoral Artery / Q000601:surgery; D005360:Fibula / Q000382:microbiology; D005500:Follow-Up Studies; D016908:Gram-Positive Bacterial Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007083:Iliac Artery / Q000601:surgery; D007383:Intermittent Claudication / Q000601:surgery; D010019:Osteomyelitis / Q000188:drug therapy / Q000209:etiology*; D010462:Peptostreptococcus / Q000302:isolation & purification; D016491:Peripheral Vascular Diseases / Q000601:surgery; D016459:Prosthesis-Related Infections / Q000188:drug therapy / Q000209:etiology*
chemical_list: D000900:Anti-Bacterial Agents