[The properties of the benzodiazepine receptors of the rat cerebellum 6 months after korazol-induced kindling and recurrent seizures].
It was shown that the increased brain seizure readiness persisted within 6 months after termination of corazol kindling. Seizures of the same severity as during kindling (corazol injection in a dose of 20 mg/kg) were reproduced by corazol injection in a dose of 30 mg/kg. In contrast to the control rats, in this situation an autoenhancement of seizures was observed in the kindled animals. Acute corazol seizures induced a decrease in Bmax and Kd of 3H-diazepam binding with benzodiazepine receptors (BDR) in the cerebellum of the 10-months-old control rats white the young animals demonstrated only a decrease in Bmax of binding. In 6 months after kindling termination the BDR activity (Bmax) was reduced by one half. However, we think that the increase in Bmax is not responsible for persistence of the increased seizure readiness. It seems possible that down regulation of receptor activity develops independently of kindling but in response to long-lasting corazol application. Probably, Bmax spontaneously decreases after the termination of the long-term corazol application. The single dose of corazol (30 mg/kg) restores the changes in BDR density to the level when seizure readiness has been just fixed (6 months after kindling termination), independently of the primary receptor density.
Bazian
A S
AS
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
Zhulin
V V
VV
Karpova
M N
MN
Klishina
N Iu
NIu
Glebov
R N
RN
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects / Q000502:physiology; D002531:Cerebellum / Q000737:chemistry / Q000187:drug effects* / Q000502:physiology; D003292:Convulsants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007696:Kindling, Neurologic / Q000187:drug effects* / Q000502:physiology; D008297:Male; D010433:Pentylenetetrazole / Q000494:pharmacology*; D011869:Radioligand Assay; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA-A / Q000032:analysis / Q000187:drug effects* / Q000502:physiology; D012008:Recurrence; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*; D013997:Time Factors
D003292:Convulsants; D011963:Receptors, GABA-A; D010433:Pentylenetetrazole
Svoĭstva benzodiazepinovykh retseptorov mozzhechka krys cherez shest' mesiatsev posle korazolovogo kindlinga i povtornykh sudorog.