title: [Controlled release antigen from the injection site--new model for a single-shot vaccination?].
abstract: Continuously increasing number of available vaccines and a wide use of mass vaccination campaigns lead to the development of simpler methods of vaccine delivery. There is the WHO-sponsored project, including several scientific groups, which aims to reduce the number of repeated administrations of vaccines required for long-term protection and to obviate the need for booster immunization. Such a task may be achieved by the use of controlled-release parenteral systems. One such delivery system comprises microspheres constructed from biodegradable, biocompatible polymers based on poly lactic/glycolic acid. Recent developments of a single-shot tetanus toxoid, encapsulated in the biodegradable polymeric microspheres or microcapsules are reviewed. There are promising advances in the WHO-sponsored project. However, further efforts are needed to elaborate an affective late release of antigen and to obtain a strong booster effect in vaccinated animals.
authors.affiliation: Zakład Badania Surowic i Szczepionek Państwowego Zakładu Higieny w Warszawie.
authors.forename: A
authors.initials: A
authors.lastname: Gałazka
authors.forename: T
authors.initials: T
authors.lastname: Wysokińska
mesh_terms: D000328:Adult; D001672:Biocompatible Materials; D001673:Biodegradation, Environmental; D002648:Child; D003692:Delayed-Action Preparations; D006801:Humans; D007115:Immunization Schedule; D008863:Microspheres; D013742:Tetanus / Q000517:prevention & control*; D013745:Tetanus Toxoid / Q000008:administration & dosage*; D014944:World Health Organization
chemical_list: D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D013745:Tetanus Toxoid
vernacular_title: Kontrolowane uwalnianie antygenu z miejsca wstrzykniecia szczepionki--nowy model jednodawkowej szczepionki?