title: [Metastatic potential correlates with cell surface carbohydrate profiles of nasopharyngeal carcinoma].
abstract: In order to investigate the changes in glycoprotein structure between non-metastatic and metastatic cells of nasopharyngerl carcinoma (NPC), peanut agglutinin (PNA), ulex europeaus (UEA-I) and concanavalin ensifomis agglutinin (ConA) staining were used to examine 102 nasopharyngeal carcinoma tissues (84 primary tumors and 18 metastatic lymph nodes) with the avidin-biotinperoxidase complex method. PNA reaction was positive in most cells of nasopharyngeal carcinomas regardles of in histopathologic type, the degree of differentiation and metastasis. The levels of UEA-I receptors apparently increased during nasopharyngeal carcinoma progression from non-metastatic to metastatic tumors. The binding to ConA clearly decreased in the cells of metastatic cases and metastatic lymph node. So, the increased expression of UEA-I receptors and decrease of ConA receptors on tumor cells might have been implicated in the expression of metastatic potential.
authors.affiliation: Changhai Hospital, Second Military University.
authors.forename: H
authors.initials: H
authors.lastname: Huang
authors.forename: D
authors.initials: D
authors.lastname: Jiang
authors.forename: Z
authors.initials: Z
authors.lastname: Li
mesh_terms: D010367:Arachis; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000556:secondary; D006801:Humans; D008207:Lymphatic Metastasis; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D011956:Receptors, Cell Surface; D011952:Receptors, Concanavalin A / Q000378:metabolism*; D011975:Receptors, Mitogen / Q000378:metabolism*
chemical_list: D011956:Receptors, Cell Surface; D011952:Receptors, Concanavalin A; D011975:Receptors, Mitogen; C053203:Ulex europaeus lectin receptor; C038223:peanut agglutinin receptor