Urinary endothelin-1 in children with acute renal failure of tubular origin.
To understand the changes of urinary endothelin-1 (ET-1) concentrations in acute renal failure (ARF) and to investigate the origin of human urinary ET-1, we studied urinary ET-1 excretion in 70 normal children and 12 children with ARF caused by tubular dysfunction. Urinary ET-1 excretion was expressed as a ratio of urinary ET-1 to urinary creatinine (ET-1/Cr). Among healthy children, the highest urinary ET-1/Cr values were found during infancy. In patients with ARF, there was a positive correlation between urinary ET-1/Cr values and daily total urinary ET-1 (r = 0.42, n = 26, p < 0.05). Plasma ET-1 concentrations were elevated in children with ARF during the period of peak serum creatinine concentration. During the course of ARF, the lowest urinary ET-1/Cr value occurred during the period of peak serum creatinine, whereas the plasma ET-1 concentration declined after the peak. These results provide insight into the developmental changes of urinary ET-1 values in normal children, and illustrate the pattern of changes in plasma and urinary ET-1 concentrations during the course of ARF in children. The results suggest that renal production, rather than clearance from the circulation by glomerular filtration, may be the source of urinary ET-1.
Tsau
Y K
YK
Department of Pediatrics, National Taiwan University Hospital, Taipei.
Tsai
W S
WS
Chen
C H
CH
D058186:Acute Kidney Injury / Q000652:urine*; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D019332:Endothelin-1 / Q000097:blood / Q000652:urine*; D006801:Humans; D007684:Kidney Tubules / Q000378:metabolism
D019332:Endothelin-1