title: Some perspectives on modeling leukemia.
abstract: A diffusion model of leukemia is presented. The space-occupying effects of leukemic cells during leukemic expansion is investigated. The analyses and simulations of the model suggest that acute leukemia is a state in which positions inhabited by colonies of normal cells are invaded by emerging colonies of abnormal cells. Normal cells are then driven to a state of extinction as leukemic cells evolve toward high and dominant steady state levels.
authors.affiliation: Department of Mathematics, Elmhurst College, IL 60126, USA. evansa@elmhurst.edu
authors.forename: E K
authors.initials: EK
authors.lastname: Afenya
authors.forename: D E
authors.initials: DE
authors.lastname: Bentil
mesh_terms: D002455:Cell Division; D002465:Cell Movement; D003198:Computer Simulation; D006801:Humans; D007938:Leukemia / Q000473:pathology*; D008954:Models, Biological