Nonconvulsive status epilepticus in two patients receiving tiagabine treatment.
In the course of an open study on the add-on treatment of tiagabine (TGB) in patients with localization-related epilepsy syndromes, 2 of 9 patients developed nonconvulsive status epilepticus (NCSE) with electroclinical features consistent with those of atypical absence seizures. One patient had never had atypical absence seizures before. In both cases, immediate discontinuation of TGB was followed by complete and sustained electroclinical remission; we suggest a possible causative role of TGB. This observation may be consistent with a paradoxical effect of TGB in selected cases. Possible risk factors and a pathophysiological hypothesis are discussed.
Eckardt
K M
KM
Department of Clinical Neurophysiology, Georg-August Universität, Göttingen, Germany.
Steinhoff
B J
BJ
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004569:Electroencephalography / Q000706:statistics & numerical data*; D004827:Epilepsy / Q000188:drug therapy; D004832:Epilepsy, Absence / Q000139:chemically induced* / Q000175:diagnosis; D005260:Female; D006801:Humans; D009557:Nipecotic Acids / Q000009:adverse effects* / Q000627:therapeutic use; D013226:Status Epilepticus / Q000139:chemically induced* / Q000175:diagnosis; D000078308:Tiagabine
D000927:Anticonvulsants; D009557:Nipecotic Acids; D000078308:Tiagabine