A Taenia solium oncosphere protein homologous to host-protective Taenia ovis and Taenia saginata 18 kDa antigens.
A Taenia solium cDNA (TSOL-18) encoding a protein with close homology to host protective oncosphere antigens from Taenia ovis (To18) and Taenia saginata (TSA-18) is described here. TSOL-18 was cloned from mRNA obtained from hatched and activated oncospheres of T. solium. The high level of predicted amino acid sequence homology among TSOL-18 and other host protective taeniid antigens suggests that the protein expressed by TSOL-18 may be capable of being used as a vaccine against T. solium infection in the parasite's intermediate hosts.
Gauci
C G
CG
Molecular Parasitology Laboratory, University of Melbourne, Werribee, Victoria, Australia. c.gauci@vet__science.unimelb.edu.au
Flisser
A
A
Lightowlers
M W
MW
D000595:Amino Acid Sequence; D000818:Animals; D000947:Antigens, Helminth / Q000737:chemistry* / Q000235:genetics* / Q000276:immunology; D001483:Base Sequence; D003001:Cloning, Molecular; D018076:DNA, Complementary; D018509:DNA, Helminth / Q000235:genetics; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D013621:Taenia / Q000235:genetics* / Q000276:immunology; D013622:Taeniasis / Q000276:immunology / Q000517:prevention & control
D000947:Antigens, Helminth; D018076:DNA, Complementary; D018509:DNA, Helminth; C113407:TSOL-18 antigen