title: [The mechanisms of progesterone treatment on endometrial carcinoma].
abstract: OBJECTIVE
  To study the mechanisms of the exogenic progestrerone treatment on endometrial carcinoma.
  
  
  METHODS
  We observed the morphologic changes of the endometrial cancer cells treated by exogenic progesterone with light and electronic microscopy.
  
  
  RESULTS
  The main changes of the tumor cell treated were well differentiation, increase in secretory activity and apoptosis of tumor cells.
  
  
  CONCLUSIONS
  Progesterone may directly affect tumor cells, inhibit the growth of tumor cells and lead to well differentiation. Clinically with preoperative and postoperative progesterone therapy, it can decrease the peritoneum implantation and metastasis, and also decrease the recurrence after operation.
authors.affiliation: Shanghai Ruijin Hospital.
authors.forename: C
authors.initials: C
authors.lastname: Chen
authors.forename: Z
authors.initials: Z
authors.lastname: Hua
authors.forename: X
authors.initials: X
authors.lastname: Jin
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000648:ultrastructure; D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D016889:Endometrial Neoplasms / Q000188:drug therapy* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D006908:Hydroxyprogesterones / Q000627:therapeutic use*; D008875:Middle Aged
chemical_list: D018931:Antineoplastic Agents, Hormonal; D006908:Hydroxyprogesterones