Increased release of IAPP in response to long-term high fat intake in mice.
In the present study, mice were fed high-fat diet or standard animal chow during 6 months. Animals fed high-fat diet showed a 4.5-fold increase in the fasting plasma IAPP levels compared to animals fed standard chow. No significant change in plasma insulin levels occurred between the groups. These differences in hormone response result in a change of the molar ratio between IAPP and insulin in the group fed high-fat diet. An increased IAPP to insulin molar ratio might be important in the pathogenesis of islet amyloid in man.
Westermark
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Division of Molecular and Immunological Pathology, Faculty of Health Sciences, Linköping University, Sweden.
Leckström
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Westermark
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D000682:Amyloid / Q000097:blood / Q000378:metabolism*; D000818:Animals; D004032:Diet; D004041:Dietary Fats / Q000494:pharmacology*; D005227:Fatty Acids / Q000494:pharmacology*; D007328:Insulin / Q000032:analysis / Q000097:blood; D058228:Islet Amyloid Polypeptide; D007515:Islets of Langerhans / Q000737:chemistry; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013997:Time Factors; D015430:Weight Gain
D000682:Amyloid; D004041:Dietary Fats; D005227:Fatty Acids; D007328:Insulin; D058228:Islet Amyloid Polypeptide