Conduction block in vasculitic neuropathy.
Vasculitis involving peripheral nerves usually presents as an acute asymmetrical axonal neuropathy. We report a 67-year-old man with a symmetrical subacute neuropathy in which nerve conduction studies showed prominent conduction block, a finding indicative of demyelination. Sural nerve biopsy showed a vasculitic neuropathy with invasion of blood vessel walls by inflammatory cells and a mixture of nerve fiber loss and demyelination. The demyelination in this case was presumably a consequence of subinfarctive nerve ischemia.
Mohamed
A
A
Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney, Australia.
Davies
L
L
Pollard
J D
JD
D000200:Action Potentials / Q000502:physiology; D000368:Aged; D001706:Biopsy; D003711:Demyelinating Diseases / Q000473:pathology; D019054:Evoked Potentials, Motor / Q000502:physiology; D006801:Humans; D008297:Male; D008475:Median Nerve / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology; D009431:Neural Conduction / Q000502:physiology*; D010523:Peripheral Nervous System Diseases / Q000473:pathology / Q000503:physiopathology*; D013497:Sural Nerve / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology; D014459:Ulnar Nerve / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology; D014657:Vasculitis / Q000503:physiopathology*