[Effect of ephedrine and support loads on development of osteopenia and growth of shin bones in suspended rats].
Effects of graded support loads and stimulators of the central nervous system (ephedrine and strychnine) on growth of bones and the volume of spongy bone tissue in the proximal metaphyses of the shin bones were studied in the 14-day experiment with rats suspended by tail in the orthostatic position. It is indicated that the support loads in combination with ephedrine injection prevent the suspension-induced inhibition of bone growth and development of osteopenia of spongiosa of metaphyses. The preventive effect of support loads and ephedrine relates with their stimulating influence on the functional activity of the STH-cells of adenohypophysis producing the growth hormone.
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D000818:Animals; D001851:Bone Diseases, Metabolic / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003292:Convulsants / Q000494:pharmacology; D004195:Disease Models, Animal; D004809:Ephedrine / Q000494:pharmacology*; D005500:Follow-Up Studies; D018475:Head-Down Tilt / Q000009:adverse effects; D008297:Male; D051381:Rats; D012149:Restraint, Physical; D013331:Strychnine / Q000494:pharmacology; D013977:Tibia / Q000166:cytology / Q000187:drug effects / Q000254:growth & development*; D016474:Weight-Bearing
D000697:Central Nervous System Stimulants; D003292:Convulsants; D004809:Ephedrine; D013331:Strychnine
Vliianie éfedrina i opornykh nagruzok na razvitie osteopeniĭ i rost bol'shebertsovykh kosteĭ u krys pri vyveshivanii.