Transforming growth factor-beta in renal disease.
An extensive number of animal and clinical studies indicate that transforming growth factor-beta (TGF-beta s) play an important role in inflammatory and fibrotic diseases, including renal fibrosis. Recent mouse models harboring genetically engineered alterations in TGF-beta pathways reveal complicated mechanisms of regulation of TGF-beta activity in vivo. The purpose of this review is to present recent advances relevant to our understanding of the TGF-beta-signaling system in renal physiology and pathophysiology.
Bitzer
M
M
Medizinische Klinik IV mit Poliklinik, Friedrich-Alexander Universität Erlangen-Nürnberg, Germany. Markus.Bitzer@rzmail.uni-erlangen.de
Sterzel
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Böttinger
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D000818:Animals; D004195:Disease Models, Animal; D005355:Fibrosis / Q000378:metabolism; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism*
D018125:Receptors, Transforming Growth Factor beta; D016212:Transforming Growth Factor beta