title: Cutaneous angiosarcoma with eyelid involvement.
abstract: OBJECTIVE
  To report a clinicopathologic correlation of angiosarcoma affecting the eyelid skin.
  
  
  METHODS
  An 82-year-old man developed multiple bruise-like maculopapular lesions, subcutaneous nodules, and diffuse edema over his scalp, face, and eyelids. Biopsy disclosed angiosarcoma, and the patient was treated with wide-field external beam radiotherapy (5,000 cGy).
  
  
  RESULTS
  He responded to radiotherapy with partial regression of the tumor. Twelve months later, he developed extensive lymphedema secondary to the residual tumor. He was also found to have parotid gland and bone metastases, treated with radiotherapy. The patient died of widespread bone metastases 3 months later.
  
  
  CONCLUSIONS
  Angiosarcoma is a rare skin tumor that has a poor prognosis despite treatment. It should be considered in the differential diagnosis of eyelid tumors and edema because it may affect only the central portion of the face.
authors.affiliation: Oncology Service, Wills Eye Hospital, Philadelphia, Pennsylvania 19107, USA.
authors.forename: K
authors.initials: K
authors.lastname: Gündüz
authors.forename: J A
authors.initials: JA
authors.lastname: Shields
authors.forename: C L
authors.initials: CL
authors.lastname: Shields
authors.forename: R C
authors.initials: RC
authors.lastname: Eagle
authors.forename: F
authors.initials: F
authors.lastname: Nathan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000532:radiotherapy / Q000556:secondary*; D005142:Eyelid Neoplasms / Q000150:complications / Q000473:pathology* / Q000532:radiotherapy; D006394:Hemangiosarcoma / Q000532:radiotherapy / Q000556:secondary*; D006801:Humans; D008209:Lymphedema / Q000209:etiology; D008297:Male; D010307:Parotid Neoplasms / Q000532:radiotherapy / Q000556:secondary*; D012878:Skin Neoplasms / Q000150:complications / Q000473:pathology* / Q000532:radiotherapy