[Fluctuations of serotonin and its metabolites in the lung and intestinal mucosa in the rat infected with Nippostrongylus brasiliensis].
The influence of parasitism on host biogenic amine levels was investigated in Nippostrongylus brasiliensis infected rats. Amine levels were estimated in tissues surrounding Nematods in their biological environment: the lung and intestinal mucus. D0 being the day of infestation, tissues were obtained at 24, 30 and 45 hrs, and every day between D4 and D14 (when the rat was completely deparasited by the self-cure phenomenon). Biogenic amines belonging to the serotoninergic pathway were quantified by HPLC with electrochemical detection. In the lungs and mucus, parasitism resulted in an important decrease in serotonine (5-HT) and 5-hydroxyindolacetic acid (5-HIAA) levels, as opposed to the immediate 5-HT precursor, the 5-hydroxy-tryptophane (5-HTP). Host response to parasitism is translated by serotoninergic pathway levels. This leads to two hypotheses: 5-HT turn-over may be accelerated, but the inhibition of 5-HT synthetic enzyme, 5-hydroxytryptophane hydroxylase, by the parasite present in the host seems more probable.
Grosclaude
J M
JM
Laboratoire de pharmacodynamie, Faculté de pharmacie, Châtenay-Malabry, France.
Goudey-Perrière
F
F
Gayral
P
P
Jacquot
C
C
Barreteau
H
H
D000818:Animals; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism*; D008168:Lung / Q000378:metabolism*; D008297:Male; D009559:Nippostrongylus; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism*; D017206:Strongylida Infections / Q000378:metabolism*
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid
Fluctuations de la sérotonine et de ses métabolites au niveau du poumon et du mucus intestinal chez le rat infesté par Nippostrongylus brasiliensis.