title: Exacerbation of atopic dermatitis after bacillus Calmette-Guérin vaccination.
abstract: In two children with atopic dermatitis, routine vaccination with bacillus Calmette-Guérin (BCG) was followed by severe exacerbation of skin disease. If the sequence is cause and effect, a possible mechanism is stimulation of a Th2 lymphocyte cytokine profile by the vaccine, with migration of activated lymphocytes to inflamed skin. In children with active atopic dermatitis, BCG vaccination is best deferred until remission.
authors.affiliation: Department of Child Health, University of Manchester, Booth Hall Children's Hospital, Blackley, UK.
authors.forename: S J
authors.initials: SJ
authors.lastname: Dalton
authors.forename: M R
authors.initials: MR
authors.lastname: Haeney
authors.forename: L
authors.initials: L
authors.lastname: Patel
authors.forename: T J
authors.initials: TJ
authors.lastname: David
mesh_terms: D000367:Age Factors; D001500:BCG Vaccine / Q000009:adverse effects*; D002648:Child; D003876:Dermatitis, Atopic / Q000209:etiology* / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D014611:Vaccination / Q000009:adverse effects*
chemical_list: D001500:BCG Vaccine