Diffuse anterior retinoblastoma.
OBJECTIVE
The authors describe the clinicopathologic features of an anterior variant of diffuse retinoblastoma.


METHODS
The clinical history of a child with an anterior chamber infiltrate and cells in the anterior vitreous was reviewed. An anterior chamber aspirate was processed by a Millipore filter technique. The eye was enucleated and routinely processed for light and transmission electron microscopic examination.


RESULTS
An 8-year-old girl was treated for anterior uveitis in her right eye that failed to resolve. Examination of an anterior chamber aspirate showed cells suggestive of retinoblastoma. The eye was enucleated, and the enucleation specimen showed retinoblastoma confined to the iris, ciliary body, and anterior vitreous with one microscopic focus of tumor in the peripheral retina.


CONCLUSIONS
This variant of diffuse retinoblastoma involved only anterior ocular structures with minimal involvement of the retina.
Grossniklaus
H E
HE
Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.
Dhaliwal
R S
RS
Martin
D F
DF
D000867:Anterior Chamber / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D001707:Biopsy, Needle; D002648:Child; D002924:Ciliary Body / Q000473:pathology; D015353:Eye Enucleation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007498:Iris / Q000473:pathology; D009361:Neoplasm Invasiveness; D019572:Retinal Neoplasms / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D012175:Retinoblastoma / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D014822:Vitreous Body / Q000473:pathology