title: Reproducibility of 1H-NMR integrals: a collaborative study.
abstract: The quantitative use of NMR spectroscopy was investigated by a reproducibility study of 1H-NMR integrals involving five laboratories. A significant laboratory effect was found confirming the difficulty to obtain very precise data by integration of complex signals. The reproducibility of any NMR assay measurement, which requires a high precision should be validated by an interlaboratory study.
authors.affiliation: Sanofi Recherche, Toulouse, France.
authors.forename: M
authors.initials: M
authors.lastname: Bauer
authors.forename: A
authors.initials: A
authors.lastname: Bertario
authors.forename: G
authors.initials: G
authors.lastname: Boccardi
authors.forename: X
authors.initials: X
authors.lastname: Fontaine
authors.forename: R
authors.initials: R
authors.lastname: Rao
authors.forename: D
authors.initials: D
authors.lastname: Verrier
mesh_terms: D005069:Evaluation Studies as Topic; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D015203:Reproducibility of Results