[Responses of growth hormone and prolactin to L-Dopa in women with polycystic ovarian syndrome].
OBJECTIVE
To evaluate the altered dopaminergic modulation of growth hormone (GH) and prolactin (PRL) in polycystic ovarian syndrome (PCOS).


METHODS
Responses of GH and PRL to L-Dopa (L-DA) (500 mg) were observed in two PCOS groups (LH/FSH > or = 3, Group I, n = 15, LH/FSH < 3, Group II, n = 15) and the control (n = 20).


RESULTS
Significantly lower GH (P < 0.01) and higher PRL levels (P < 0.05 in group I) in the basal state, and lower responses of GH and PRL to L-DA were found in two PCOS groups as compared with the control.


CONCLUSIONS
The altered basal levels and blunted L-DA evoked responses of GH and PRL suggest a relative decrease of the dopaminergic activity in PCOS patients.
Wu
X
X
Nanjing Jinling Hospital.
Gu
Q
Q
Su
Y
Y
D000328:Adult; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007980:Levodopa / Q000494:pharmacology*; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D011388:Prolactin / Q000097:blood*
D007980:Levodopa; D011388:Prolactin; D013006:Growth Hormone