Clinical and biochemical determinants of plasma lipid peroxide levels in type 2 diabetes.
The enhanced risk and increased severity of atheroma in diabetes is well recognized but, as yet, incompletely explained. A cross-sectional study of vascular disease risk factors in a group of type 2 diabetic patients from South West Scotland has revealed an association between glycaemic control, assessed by HbAl level and plasma lipid peroxides measured by a specific high-performance liquid chromatography method. Duration of diabetes appeared to be a subsidiary contributor to lipid peroxidation. We suggest this evidence supports the importance of glycaemic control in modulating glyco-oxidative mechanisms probably crucial to production of diabetic complications. Atherosclerosis prevention in diabetes may hinge on exemplary simultaneous control of both hyperglycaemia and hyperlipidaemia.
Lawrence
J R
JR
Department of Medicine, Dumfries & Galloway Royal Infirmary.
Campbell
G R
GR
Barrington
H
H
Malcolm
E A
EA
Brennan
G
G
Wiles
D H
DH
Paterson
J R
JR
D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008054:Lipid Peroxides / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012907:Smoking / Q000097:blood
D007004:Hypoglycemic Agents; D008054:Lipid Peroxides