Human antibody response to Moraxella catarrhalis antigens.
Moraxella catarrhalis was isolated from 68 of 200 (34%) sputum and 56 (28%) nasopharyngeal swab samples of patients with community-acquired pneumonia. Of the 68 pneumonia patients, 42 (61.8%) were males and 26 (38.2%) females. Fifty one of the 68 patients (75%) had chronic underlying diseases. beta-lactamase was produced by 37 (54.4%) of the 68 sputum samples and 32(57.1%) of the 56 nasopharyngeal isolates. In an ELISA using outer membrane protein antigens of M. catarrhalis against patient sera showed 40 of 68 (58.8%), and 43 of 68 (63.2%) significant increase in convalescent to acute sera when IgA, IgM and IgG3 were used respectively. In control sera only of 30(3.3%) and none showed significant antibody rise when IgA, IgM and IgG3 conjugates were used respectively (P < 0.05).
Gabre-Selasie
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Department of Medical Microbiology and Parasitology, Jimma Institute of Health Sciences, Ethiopia.
D000209:Acute-Phase Proteins / Q000276:immunology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000097:blood*; D000942:Antigens, Bacterial / Q000276:immunology*; D016022:Case-Control Studies; D017714:Community-Acquired Infections / Q000097:blood / Q000276:immunology / Q000382:microbiology*; D003289:Convalescence; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood*; D008297:Male; D008875:Middle Aged; D001936:Moraxella catarrhalis / Q000201:enzymology / Q000276:immunology*; D009297:Nasal Mucosa / Q000382:microbiology; D016870:Neisseriaceae Infections / Q000097:blood / Q000276:immunology / Q000382:microbiology*; D018410:Pneumonia, Bacterial / Q000097:blood / Q000276:immunology / Q000382:microbiology*; D013183:Sputum / Q000382:microbiology; D001618:beta-Lactamases / Q000096:biosynthesis
D000209:Acute-Phase Proteins; D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D001618:beta-Lactamases