title: Freeze-drying of bioproducts: putting principles into practice.
abstract: The product and process parameters that determine successful freeze-drying are described and their interrelationships are explored. It is shown that the thermochemical and thermomechanical properties of water-soluble, amorphous materials form the basis of effective formulation design and that coordinated approaches to formulation and process development achieve optimum results with a minimum of trial-and-error experimentation.
authors.affiliation: BioUpdate Foundation, Cambridge, UK. bioup@dial.pipex.com
authors.forename: F
authors.initials: F
authors.lastname: Franks
mesh_terms: D001688:Biological Products / Q000737:chemistry*; D004355:Drug Stability; D005612:Freeze Drying / Q000379:methods
chemical_list: D001688:Biological Products