Influence of felodipine on experimental seizures and activity of different antiepileptic drugs in mice.
Effects of felodipine, the calcium channel blocker, on the electroshock, pentetrazole-, aminophylline-, and pilocarpine-induced seizures and on the anticonvulsant activity of different antiepileptic drugs against maximal electroshock were examined in mice. Felodipine increased the threshold for electroconvulsions. The drug exerted also a protective effect against pentetrazole-induced seizures, but not against aminophylline- and pilocarpine-induced seizures. The protective efficacy of diazepam and diphenylhydantoin (but not phenobarbital and valproate) against electroconvulsions was significantly enhanced by felodipine. A pharmacokinetic interaction did not seem to be responsible for the interaction of felodipine with antiepileptic drugs in the maximal electroshock test.
Waciński
P
P
Department of Pharmacology, Medical University School, Lublin, Poland.
D000628:Aminophylline / Q000097:blood; D000818:Animals; D000927:Anticonvulsants / Q000097:blood / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D015736:Felodipine / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D012640:Seizures / Q000188:drug therapy*
D000927:Anticonvulsants; D002121:Calcium Channel Blockers; D000628:Aminophylline; D015736:Felodipine