[The control of brain tissue temperature and stimulation of dopamine-immune system to the severe brain injury patients].
The recovery of injured neurons in primely brain damage, neuroprotection to the secondary brain damage (such as brain edema, brain ischemia, free radicals, neuroexcitation and ICP elevation), activation of gene-tropic regeneration, and prevention of apobiosis are major targets on the management of severe brain injury. However, excess release of catecholamines (catecholamine surge) make a very difficult to control of cerebral hypoxia by changes of systemic blood circulations. Mild cerebral hypothermia is only one method to prevent of these catecholamines surge. We developed new technique, cerebral hypothermia that control brain tissue temperature at 32-34 degrees C with more than 800 ml/min. oxygen delivery at acute stage. Combination therapy with these cerebral hypothermia and replacement of cerebral dopamine-pituitary hormone-estrogen was very successful to prevent of vegetation after severe brain injury.
Hayashi
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Nihon University, Department of Emergency and Critical Medicine.
D001930:Brain Injuries / Q000628:therapy*; D004298:Dopamine / Q000378:metabolism; D006801:Humans; D007036:Hypothermia, Induced; D007167:Immunotherapy / Q000379:methods
D004298:Dopamine