title: Adhesion inhibitory activity of beta-lactoglobulin isolated from infant formulae.
abstract: Beta-lactoglobulin was isolated from infant formulae that were ultra high temperature (UHT) -treated, sterilized or spray-dried. The effect of the isolated beta-lactoglobulin on SfaII-fimbriae-mediated adhesion of Escherichia coli to human ileostomy glycoproteins was studied in vitro. Beta-lactoglobulin isolated from sterilized formulae was found to perform significantly less well than preparations from spray-dried formulae (p = 0.05). Great heterogeneity was observed in the adhesion inhibitory capacity of beta-lactoglobulin isolated from UHT-treated formulae. Therefore, no significant difference was observed between UHT-treated and sterilized formulae or spray-dried formulae (p > 0.10). It can be hypothesized that beta-lactoglobulin from spray-dried and some UHT-treated infant formulae may affect the colonization of mucous membranes by E. coli strains causing neonatal septicaemia and meningitis.
authors.affiliation: Centre for Biotechnology, University of Turku, Abo Akademi University, Finland.
authors.forename: A C
authors.initials: AC
authors.lastname: Ouwehand
authors.forename: S J
authors.initials: SJ
authors.lastname: Salminen
mesh_terms: D001422:Bacterial Adhesion / Q000187:drug effects*; D004926:Escherichia coli / Q000502:physiology; D006023:Glycoproteins / Q000378:metabolism; D066298:In Vitro Techniques; D007225:Infant Food / Q000032:analysis; D007782:Lactoglobulins / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D006023:Glycoproteins; D007782:Lactoglobulins