title: [13-week subchronic oral toxicity study of phaffia colour in F344 rats].
abstract: A 13-week subchronic oral toxicity study of phaffia colour was performed in both sexes of F344 rats by feeding of CRF-1 powder diet containing 0, 0.2, 0.6, 1.7 and 5%. Rats were randomly divided into 5 groups, each consisting of 10 males and 10 females. No animals died during the administration period. There were no treatment-related changes in body weight gain, hematological and blood biochemical examination. No treatment-related histopathological changes were also observed in any dosed groups. These findings indicate that the treatment of 5% phaffia colour in diet for 13 weeks does not cause any toxicological changes in rats.
authors.affiliation: onodera@nihs.go.jp
authors.forename: H
authors.initials: H
authors.lastname: Onodera
authors.forename: K
authors.initials: K
authors.lastname: Mitsumori
authors.forename: K
authors.initials: K
authors.lastname: Yasuhara
authors.forename: K
authors.initials: K
authors.lastname: Takegawa
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
mesh_terms: D000284:Administration, Oral; D000473:Alkanes / Q000633:toxicity*; D000818:Animals; D004396:Coloring Agents / Q000633:toxicity*; D005260:Female; D008297:Male; D019800:Phenol / Q000633:toxicity*; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: C113325:2,4-dimethoxy-6-heptadecylphenol; D000473:Alkanes; D004396:Coloring Agents; D019800:Phenol