title: The complex relation between myocardial viability and functional recovery in chronic left ventricular dysfunction.
abstract: Preserved myocardial viability and recurrent symptomatic ischemia are the most widely accepted criteria indicating that coronary revascularization should take place in patients with postischemic left ventricular dysfunction. However, the presence of viable myocardium within the infarct zone does not necessarily imply recovery of function after coronary revascularization. The complex relation between the extent of transmural necrosis and the degree of residual perfusion within the infarct area plays an important role. However, independently of functional recovery, cell viability may have important clinical implications, since it may improve long-term prognosis by attenuating left ventricular remodeling processes. Several different methods are used to detect hibernating myocardium. Mounting evidence suggests that thallium-201 scintigraphy is most sensitive in identifying tissue viability, whereas dobutamine echocardiography is most specific in predicting functional recovery after revascularization. In between, myocardial contrast echocardiography is the only technique able to evaluate the microvascular integrity that is a condition sine qua non for both cell viability and later functional recovery. Combined information derived from these 3 different approaches might be considered as the best way to understand how the combination of contractile, viable but noncontractile, and dead tissue affect resultant function and prognosis.
authors.affiliation: Department of Cardiovascular and Respiratory Sciences, La Sapienza University, Rome, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Agati
authors.forename: C
authors.initials: C
authors.lastname: Autore
authors.forename: C
authors.initials: C
authors.lastname: Iacoboni
authors.forename: M
authors.initials: M
authors.lastname: Castaldo
authors.forename: G
authors.initials: G
authors.lastname: Veneroso
authors.forename: P
authors.initials: P
authors.lastname: Voci
authors.forename: F
authors.initials: F
authors.lastname: Fedele
authors.forename: A
authors.initials: A
authors.lastname: Dagianti
mesh_terms: D002316:Cardiotonic Agents; D003935:Diagnostic Techniques, Cardiovascular; D004280:Dobutamine; D015150:Echocardiography, Doppler / Q000379:methods; D006801:Humans; D017202:Myocardial Ischemia / Q000175:diagnosis*; D009206:Myocardium / Q000473:pathology*; D011877:Radionuclide Imaging / Q000379:methods; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000503:physiopathology
chemical_list: D002316:Cardiotonic Agents; D004280:Dobutamine