title: Genetic changes in inherited and sporadic ovarian carcinomas by comparative genomic hybridization: extensive similarity except for a difference at chromosome 2q24-q32.
abstract: Germ-line mutations in the BRCA1 and BRCA2 genes confer a predisposition to breast as well as ovarian carcinoma. Except for loss of the respective wild-type allele, somatic genetic changes needed for the progression of inherited ovarian tumors are unknown. A genome-wide search for such alterations was performed by comparative genomic hybridization analysis on BRCA1 and BRCA2 mutation-positive (n = 20) ovarian carcinoma specimens. Comparison with sporadic ovarian carcinomas (n = 20) revealed extensive genetic similarity between the inherited and sporadic carcinomas with the sole exception of a frequent gain of 2q24-q32 in the inherited group, suggesting the presence of an oncogene at 2q24-q32 operating in the absence of BRCA1 function. The overall similarity of gains and losses by comparative genomic hybridization suggests a common main pathway in tumor progression of both inherited and sporadic ovarian carcinomas.
authors.affiliation: Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland.
authors.forename: J
authors.initials: J
authors.lastname: Tapper
authors.forename: L
authors.initials: L
authors.lastname: Sarantaus
authors.forename: P
authors.initials: P
authors.lastname: Vahteristo
authors.forename: H
authors.initials: H
authors.lastname: Nevanlinna
authors.forename: S
authors.initials: S
authors.lastname: Hemmer
authors.forename: M
authors.initials: M
authors.lastname: Seppälä
authors.forename: S
authors.initials: S
authors.lastname: Knuutila
authors.forename: R
authors.initials: R
authors.lastname: Butzow
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics*; D005260:Female; D019398:Genes, BRCA1 / Q000235:genetics; D016147:Genes, Tumor Suppressor / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D009693:Nucleic Acid Hybridization / Q000379:methods*; D010051:Ovarian Neoplasms / Q000235:genetics*; D017354:Point Mutation / Q000235:genetics
chemical_list: D004273:DNA, Neoplasm