title: Comparison of detomidine/ketamine and guaiphenesin/thiopentone for induction of anaesthesia in horses maintained with halothane.
abstract: This prospective clinical study compared the physiological effects of two commonly used anaesthetic induction techniques in horses maintained with halothane. One hundred horses admitted for elective surgery were randomly allocated to receive either guaiphenesin (to effect) and thiopentone (5 mg/kg), or detomidine (20 microg/kg) and ketamine (2 mg/kg) for the induction of anaesthesia after acepromazine premedication. Anaesthesia was maintained with halothane in oxygen. There were no significant differences in breed, age, sex, weight, type of surgery and duration of anaesthesia between the groups. Immediately after induction of anaesthesia heart rate was higher after guaiphenesin and thiopentone, and arterial blood pressure was higher after detomidine and ketamine. Thereafter hypotension, often necessitating an infusion of dobutamine, developed in both groups. Arterial blood gases and respiratory rates were similar in the two groups. There were no significant differences between the groups in the subjectively scored quality of induction and recovery, or in recovery time.
authors.affiliation: Animal Health Trust, Newmarket, Suffolk.
authors.forename: R C
authors.initials: RC
authors.lastname: Bennett
authors.forename: P M
authors.initials: PM
authors.lastname: Taylor
authors.forename: J C
authors.initials: JC
authors.lastname: Brearley
authors.forename: C B
authors.initials: CB
authors.lastname: Johnson
authors.forename: S P
authors.initials: SP
authors.lastname: Luna
mesh_terms: D000700:Analgesics / Q000008:administration & dosage*; D000768:Anesthesia, General / Q000662:veterinary*; D000778:Anesthetics, Dissociative / Q000008:administration & dosage*; D018685:Anesthetics, Inhalation / Q000008:administration & dosage*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D000818:Animals; D001794:Blood Pressure; D004359:Drug Therapy, Combination; D005100:Expectorants / Q000008:administration & dosage*; D005260:Female; D006140:Guaifenesin; D006221:Halothane; D006339:Heart Rate; D006736:Horses / Q000601:surgery; D007093:Imidazoles; D007649:Ketamine; D008297:Male; D011446:Prospective Studies; D013514:Surgical Procedures, Operative / Q000662:veterinary; D013874:Thiopental
chemical_list: D000700:Analgesics; D000778:Anesthetics, Dissociative; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D005100:Expectorants; D007093:Imidazoles; D006140:Guaifenesin; D007649:Ketamine; C041255:detomidine; D013874:Thiopental; D006221:Halothane