Malignant cerebellar astrocytoma developing 15 years after radiation therapy for a medulloblastoma.
A case of malignant cerebellar astrocytoma occurring 15 years after the radiation therapy for a medulloblastoma is reported. The tumor developed at the same site of irradiation after a sufficient latent period and was completely different from medulloblastoma in its histology. This tumor fulfilled the criteria of radiation-induced neoplasm. Only seven similar cases have been reported up to the present. Whole neuraxis irradiation following a gross total resection is a standard treatment for medulloblastoma, but the possibility of the development of radiation-induced tumors must be borne in mind for a long time after the radiation therapy for medulloblastoma.
Furuta
T
T
Department of Neurological Surgery, Okayama University Medical School, Japan.
Sugiu
K
K
Tamiya
T
T
Matsumoto
K
K
Ohmoto
T
T
D000328:Adult; D001254:Astrocytoma / Q000209:etiology* / Q000473:pathology; D002528:Cerebellar Neoplasms / Q000209:etiology / Q000473:pathology / Q000532:radiotherapy*; D002648:Child; D016371:Cranial Irradiation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000532:radiotherapy*; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D013997:Time Factors