Injection of T-cell receptor peptide reduces immunosenescence in aged C57BL/6 mice.
Previous studies established that retrovirally infected young mice produced large amounts of autoantibodies to certain T-cell receptor (TCR) peptides whose administration diminished retrovirus-induced immune abnormalities. C57BL/6 young (4 weeks) and old (16 months) female mice were injected with these same synthetic human TCR V beta 8.1 or 5.2 peptides. Administration of these autoantigenic peptides to old mice prevent immunosenescence, such as age-related reduction in splenocyte proliferation and interleukin-2 (IL-2) secretion. TCR V beta peptide injection into young mice had no effect on T- or B-cell mitogenesis and IL-4 production while modifying tumour necrosis factor-alpha (TNF-alpha), IL-6, and interferon-gamma (IFN-gamma) secreted by mitogen-stimulated spleen cells. TCR V beta injection also retarded the excessive production of IL-4, IL-6 and TNF-alpha induced by ageing. These data suggest that immune dysfunction and abnormal cytokine production, induced by the ageing process, were largely prevented by injection of selected TCR V beta CDR1 peptides.
Liang
B
B
Arizona Prevention Center, Tucson 85724, USA.
Zhang
Z
Z
Inserra
P
P
Jiang
S
S
Lee
J
J
Garza
A
A
Marchalonis
J J
JJ
Watson
R R
RR
D000375:Aging / Q000276:immunology*; D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis; D001835:Body Weight; D002455:Cell Division / Q000276:immunology; D016207:Cytokines / Q000096:biosynthesis; D005260:Female; D006801:Humans; D007108:Immune Tolerance; D051379:Mice; D008810:Mice, Inbred C57BL; D008934:Mitogens / Q000276:immunology; D010446:Peptide Fragments / Q000276:immunology*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology*; D013154:Spleen / Q000276:immunology
D001323:Autoantibodies; D016207:Cytokines; D008934:Mitogens; D010446:Peptide Fragments; D016693:Receptors, Antigen, T-Cell, alpha-beta; C113248:T cell receptor peptide Vbeta5.2; C113249:T cell receptor peptide Vbeta8.1