title: CSF levels of carnitine in children with meningitis, neurologic disorders, acute gastroenteritis, and seizure.
abstract: Carnitine concentrations in CSF, serum, and urine in normal febrile children and children with meningitis, neurologic disorders, and dehydration were studied. Carnitine levels in CSF were 1/10 compared with serum in normal febrile children. These levels increased two- to three-fold in the pathologic conditions studied. Since damage to the blood-brain barrier occurs in these conditions, higher blood-brain barrier permeability might explain CNS carnitine accumulation.
authors.affiliation: Department of Pediatrics, Carmel Medical Center, Haifa, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Shinawi
authors.forename: N
authors.initials: N
authors.lastname: Gruener
authors.forename: A
authors.initials: A
authors.lastname: Lerner
mesh_terms: D000293:Adolescent; D002331:Carnitine / Q000097:blood / Q000134:cerebrospinal fluid* / Q000652:urine; D002648:Child; D002675:Child, Preschool; D005260:Female; D005334:Fever / Q000097:blood / Q000134:cerebrospinal fluid / Q000652:urine; D005759:Gastroenteritis / Q000097:blood / Q000134:cerebrospinal fluid* / Q000652:urine; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D016920:Meningitis, Bacterial / Q000097:blood / Q000134:cerebrospinal fluid* / Q000652:urine; D009422:Nervous System Diseases / Q000097:blood / Q000134:cerebrospinal fluid* / Q000652:urine; D009994:Osmolar Concentration; D012016:Reference Values; D012640:Seizures / Q000097:blood / Q000134:cerebrospinal fluid* / Q000652:urine
chemical_list: D002331:Carnitine