Association of the oral flora with important medical diseases.
Recently, there have been case-control and epidemiologic investigations that strongly associate poor dental health with cardiovascular disease, preterm low birth weight infants, and early death from any cause. In a 7-year prospective study, dental disease was a significant predictor of coronary events leading to death after controlling for known coronary disease risk factors. Missing teeth displaces smoking as a risk factor for ischemic heart disease in another study. Periodontal disease was seven times more likely to be associated with a preterm delivery of a low birth weight infant than mother's age, race, number of live births, and use of tobacco or alcohol. This review examines the role of asymptomatic bacteremia as possibly explaining these associations, focusing on the bacterial load on the teeth as mediated via oral hygiene.
Loesche
W J
WJ
University of Michigan School of Dentistry, Department of Biologic and Material Sciences, Ann Arbor 48109, USA.
D016470:Bacteremia / Q000382:microbiology; D001421:Bacteria, Anaerobic / Q000472:pathogenicity*; D001724:Birth Weight / Q000502:physiology; D002318:Cardiovascular Diseases / Q000209:etiology / Q000382:microbiology*; D003731:Dental Caries / Q000150:complications; D003753:Dental Health Surveys; D003773:Dental Plaque / Q000150:complications / Q000382:microbiology; D005491:Focal Infection, Dental / Q000150:complications*; D006304:Health Status; D006305:Health Status Indicators; D006801:Humans; D007230:Infant, Low Birth Weight / Q000276:immunology; D007231:Infant, Newborn; D009055:Mouth / Q000382:microbiology*; D009910:Oral Hygiene; D010510:Periodontal Diseases / Q000150:complications* / Q000382:microbiology; D016388:Tooth Loss / Q000150:complications