The intercellular adhesion molecule (ICAM) family of proteins. New members and novel functions.
Macromolecular adhesive associations between cells are important for transmitting spatial and temporal information that is critical for immune system function. One such group of proteins, the intercellular adhesion molecules (ICAMs), has grown as newly identified members are revealed. In addition, the functions of the ICAMs, in general, have begun to be better understood, including intracellular signaling events. This information has led to the design of novel therapeutic agents that may prove effective in a variety of disease states.
Hayflick
J S
JS
ICOS Corp., Bothell, WA 98021, USA. jhayflick@icos.com
Kilgannon
P
P
Gallatin
W M
WM
D000595:Amino Acid Sequence; D015703:Antigens, CD / Q000737:chemistry / Q000502:physiology*; D000943:Antigens, Differentiation; D015815:Cell Adhesion Molecules / Q000737:chemistry / Q000502:physiology*; D002450:Cell Communication / Q000502:physiology*; D017124:Conserved Sequence; D003593:Cytoplasm / Q000737:chemistry; D015195:Drug Design; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000737:chemistry / Q000502:physiology; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000502:physiology; D017386:Sequence Homology, Amino Acid
D015703:Antigens, CD; D000943:Antigens, Differentiation; D015815:Cell Adhesion Molecules; C065289:ICAM2 protein, human; C483616:ICAM3 protein, human; C095100:ICAM4 protein, human; C086747:ICAM5 protein, human; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D018799:Intercellular Adhesion Molecule-1