Some perspectives on modeling leukemia.
A diffusion model of leukemia is presented. The space-occupying effects of leukemic cells during leukemic expansion is investigated. The analyses and simulations of the model suggest that acute leukemia is a state in which positions inhabited by colonies of normal cells are invaded by emerging colonies of abnormal cells. Normal cells are then driven to a state of extinction as leukemic cells evolve toward high and dominant steady state levels.
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Department of Mathematics, Elmhurst College, IL 60126, USA. evansa@elmhurst.edu
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D002455:Cell Division; D002465:Cell Movement; D003198:Computer Simulation; D006801:Humans; D007938:Leukemia / Q000473:pathology*; D008954:Models, Biological