[Dynamics of Plasmodium falciparum gametocytemia as a function of therapeutic response to chloroquine in a mesoendemic malaria zone].
Patients with Plasmodium falciparum infections were selected with an in vivo chloroquine sensitivity assay in a mesoendemic area of Senegal. Gametocytemia was studied in relation to asexual parasite responses classified as drug-sensitive or showing RI or RII resistance. Gametocyte prevalence and density appeared significantly higher in resistant infections than in sensitive ones. These observations were made on children as well as on adults. The period between first clinical symptom appearance and treatment, varying from 0 to 5 days, was not linked to asexual parasite responses, but was significantly and positively correlated to gametocyte prevalence and density observed seven days after beginning the treatment. The comparison between these results and those previously observed in a hypoendemic area suggests that the dynamic of gametocytemia is independent of the endemic level. These observations illustrate that the dissemination of chimioresistant malaria can be reinforced--via the gametocyte stage--by selective chloroquine pressure.
Robert
V
V
ORSTOM (Institut français de recherche scientifique pour le développement en coopération), Laboratoire de paludologie, Dakar, Sénégal.
Trape
J F
JF
D000293:Adolescent; D000328:Adult; D000818:Animals; D001769:Blood / Q000469:parasitology; D002648:Child; D002738:Chloroquine / Q000627:therapeutic use*; D004351:Drug Resistance; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000469:parasitology*; D010963:Plasmodium falciparum / Q000254:growth & development*; D012675:Senegal
D002738:Chloroquine
Dynamiques de la gamétocytémie à Plasmodium falciparum en fonction de la réponse thérapeutique à la chloroquine en zone de mésoendémie palustre.