Reduced expression of lipophosphoglycan (LPG) and kinetoplastid membrane protein (KMP)-11 in Leishmania donovani promastigotes in axenic culture.
The expression of surface lipophosphoglycan (LPG) and the lipophosphoglycan-associated kinetoplastid membrane protein (KMP)-11 was studied in the strain AG83 of Leishmania donovani in axenic culture. The expression of LPG and KMP-11 decreased along with parasite virulence as a function of the time of the subculture.
Mukhopadhyay
S
S
Department of Immunology, Indian Institute of Chemical Biology, Calcutta.
Sen
P
P
Majumder
H K
HK
Roy
S
S
D000818:Animals; D015152:Blotting, Northern; D015870:Gene Expression; D006028:Glycosphingolipids / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D007893:Leishmania donovani / Q000378:metabolism* / Q000472:pathogenicity; D008562:Membrane Glycoproteins / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D015800:Protozoan Proteins / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000032:analysis; D011863:Radioimmunoassay; D013997:Time Factors; D014774:Virulence
D006028:Glycosphingolipids; D008562:Membrane Glycoproteins; D015800:Protozoan Proteins; D012333:RNA, Messenger; C090009:kinetoplastid membrane protein 11, Leishmania donovani; C008290:lipophosphonoglycan