[Immunohistochemical locating and quantitative studies of 5-hydroxytryptamine and 5-hydroxytryptamine receptor in placental villi of patients with pregnancy induced hypertension].
OBJECTIVE
To supply evidence of relationship between pregnancy induced hypertension (PIH) and 5-hydroxytryptamine (5-HT) and 5-hydroxytryptamine receptor (5-HTR) synthesized by placental villi.


METHODS
Five normal placentas and 15 placentas of PIH were used for studying localization and quantification of 5-HT and 5-HTR in placental villi by using immunohistochemical and in situ quantitative methods.


RESULTS
Syncytiotrophoblasts and capillary endothelium in placental villi of control group showed 5-HT and 5-HTR positive immunoreaction, but in placental villi of group with PIH, syncytiotrophoblasts appeared 5-HT and 5-HTR weak positive immunoreaction and capillary endothelium appeared 5-HT and 5-HTR weak positive or negative immunoreaction. The results of in situ quantitation showed that the content of 5-HT and 5-HTR in placental villus syncytiotrophoblasts of group with PIH were significantly lower than those in the control group.


CONCLUSIONS
The content of 5-HT and its receptor in placenta may be related to PIH.
Ren
D
D
General Hospital of Air Force, Beijing.
Huang
W
W
Yang
M
M
D000328:Adult; D002824:Chorionic Villi / Q000737:chemistry*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D011985:Receptors, Serotonin / Q000032:analysis*; D012701:Serotonin / Q000032:analysis*
D011985:Receptors, Serotonin; D012701:Serotonin