title: Fc receptors as targets for immunotherapy.
abstract: Human membrane and soluble Fc epsilon receptors (Fc epsilon RI, Fc epsilon RII/CD23) and Fc gamma receptors (Fc gamma RI/CD64, Fc gamma RII/CD32, Fc gamma RIII/CD16) have been implicated in a number of diseases. Their functional roles such as capture and clearance of immune complexes, antibody-dependent cell cytotoxicity, or cytokine or inflammatory mediator release, make them potential targets for immuno-intervention. In the present review, we will describe how membrane and soluble human Fc epsilon R and Fc gamma R have been already used as targets/tools for immuno-interventions by using monoclonal and bispecific engineered antibodies. Some therapeutic uses of these molecules both in cancer, infectious, and auto-immune diseases are presented.
authors.affiliation: Laboratoire d'Immunologie Cellulaire et Clinique, Unité INSERM 255, Paris, France.
authors.forename: H
authors.initials: H
authors.lastname: Rouard
authors.forename: S
authors.initials: S
authors.lastname: Tamasdan
authors.forename: J
authors.initials: J
authors.lastname: Moncuit
authors.forename: S
authors.initials: S
authors.lastname: Moutel
authors.forename: J
authors.initials: J
authors.lastname: Michon
authors.forename: W H
authors.initials: WH
authors.lastname: Fridman
authors.forename: J L
authors.initials: JL
authors.lastname: Teillaud
mesh_terms: D006801:Humans; D007167:Immunotherapy; D011961:Receptors, Fc / Q000276:immunology*
chemical_list: D011961:Receptors, Fc