title: Antimicrobial activity of a compound isolated from an oil-macerated garlic extract.
abstract: A compound showing antimicrobial activity was isolated from an oil-macerated garlic extract by silica gel column chromatography and preparative TLC. On basis of the results of NMR and MS analyses, it was identified as Z-4,5,9-trithiadeca-1,6-diene-9-oxide (Z-10-devinylajoene; Z-10-DA). Z-10-DA exhibited a broad spectrum of antimicrobial activity against such microorganisms as gram-positive and gram-negative bacteria and yeasts. The antimicrobial activity of Z-10-DA was comparable to that of Z-ajoene, but was superior to that of E-ajoene. Z-10-DA and Z-ajoene are different in respect of substitution of the allyl group by the methyl group flanking a sulfinyl group. This result suggests that substitution by the methyl group would also be effective for the inhibition of microbial growth.
authors.affiliation: Biodevelopment Division, Central Institute, Nagoya Seiraku Co., Ltd., Aichi, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yoshida
authors.forename: N
authors.initials: N
authors.lastname: Iwata
authors.forename: H
authors.initials: H
authors.lastname: Katsuzaki
authors.forename: R
authors.initials: R
authors.lastname: Naganawa
authors.forename: K
authors.initials: K
authors.lastname: Ishikawa
authors.forename: H
authors.initials: H
authors.lastname: Fukuda
authors.forename: T
authors.initials: T
authors.lastname: Fujino
authors.forename: A
authors.initials: A
authors.lastname: Suzuki
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D004220:Disulfides / Q000737:chemistry*; D005737:Garlic / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry*; D010938:Plant Oils / Q000737:chemistry*; D010946:Plants, Medicinal; D013329:Structure-Activity Relationship; D013454:Sulfoxides
chemical_list: D000900:Anti-Bacterial Agents; D004220:Disulfides; D010936:Plant Extracts; D010938:Plant Oils; D013454:Sulfoxides; C048980:ajoene