Isolation and identification of bromfenac glucoside from rat bile.
Bromfenac (Duract(R)), a drug approved for pain, was expected to be metabolized by the rat to an acyl glucuronide, a metabolite formed with most compounds of similar structure. During the investigation of metabolite profiles in rat bile following administration of 1 mg/kg iv doses of 14C-bromfenac, an acid-labile metabolite was found that degraded to form 14C-bromfenac. Isolation and characterization of this metabolite indicated that it is an unusual conjugate, bromfenac N-glucoside.
Kirkman
S K
SK
Wyeth-Ayerst Research Drug Safety and Metabolism Division, Princeton, NJ 08543, USA.
Zhang
M Y
MY
Horwatt
P M
PM
Scatina
J
J
D000700:Analgesics / Q000378:metabolism*; D000818:Animals; D001577:Benzophenones / Q000378:metabolism*; D001646:Bile / Q000378:metabolism*; D001969:Bromobenzenes / Q000378:metabolism*; D005960:Glucosides / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D008297:Male; D013058:Mass Spectrometry; D051381:Rats; D017207:Rats, Sprague-Dawley
D000700:Analgesics; D001577:Benzophenones; D001969:Bromobenzenes; D005960:Glucosides; C053083:bromfenac