Long-term food restriction, deprenyl, and nimodipine treatment on life expectancy and blood pressure of stroke-prone rats.
We determined whether food restriction or the drugs nimodipine (Ca2+ antagonist) and deprenyl (a MAO-B inhibitor) prevent the development of stroke in the spontaneously hypertensive stroke-prone rat (SHR-SP). Forty male SHR-SP rats, in the age of 34 weeks, were exposed to various treatments. During a period of 27 weeks, survival and blood pressure were followed. In the control and deprenyl group, the blood pressure values remained unchanged; 50% had died after 27 weeks. All rats that were treated with nimodipine survived. After food restriction, 7/8 rats survived and showed a lower blood pressure. This study in SHR-PR rats shows the superiority of nimodipine on survival, and the potential of food restriction as a stroke-preventing measure.
Stevens
H
H
Department of Biological Psychiatry, University Hospital Groningen, Netherlands.
Knollema
S
S
De Jong
G
G
Korf
J
J
Luiten
P G
PG
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002561:Cerebrovascular Disorders / Q000235:genetics / Q000503:physiopathology*; D005508:Food Deprivation / Q000502:physiology*; D008017:Life Expectancy; D008136:Longevity / Q000187:drug effects*; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D009553:Nimodipine / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D012642:Selegiline / Q000494:pharmacology*; D016019:Survival Analysis
D002121:Calcium Channel Blockers; D008996:Monoamine Oxidase Inhibitors; D012642:Selegiline; D009553:Nimodipine