The electroneutral cation-chloride cotransporters.
Electroneutral cation-chloride cotransporters are widely expressed and perform a variety of physiological roles. A novel gene family of five members, encompassing a Na+-Cl- transporter, two Na+-K+-2Cl- transporters and two K+-Cl- cotransporters, encodes these membrane proteins; homologous genes have also been identified in a prokaryote and a number of lower eukaryotes. The cotransporter proteins share a common predicted membrane topology, with twelve putative transmembrane segments flanked by long hydrophilic N- and C-terminal cytoplasmic domains. The molecular identification of these transporters has had a significant impact on the study of their function, regulation and pathophysiology.
Mount
D B
DB
Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA.
Delpire
E
E
Gamba
G
G
Hall
A E
AE
Poch
E
E
Hoover
R S
RS
Hebert
S C
SC
D000818:Animals; D002352:Carrier Proteins / Q000502:physiology*; D002412:Cations / Q000378:metabolism*; D002712:Chlorides / Q000378:metabolism*; D006801:Humans; D017136:Ion Transport
D002352:Carrier Proteins; D002412:Cations; D002712:Chlorides