title: Adjuvant properties of killed Propionibacterium avidum KP-40 in vaccination of dogs against canine parvovirosis.
abstract: Immunomodulating and adjuvant properties of Propionibacterium avidum KP-40 (PA), a potent stimulator of the macrophage-monocyte system and inducer of endogenous interferon, were tested in healthy dogs and in dogs vaccinated against canine parvovirosis (CPV). A single subcutaneous injection of PA (0.5 mg/kg b. m.) was administered either 10 days before or simultaneously with CPV immunization. The immunomodulating properties of PA were expressed by enhancement of phagocytic and bactericidal activities of blood leukocytes, accompanied by elevated serum levels of interferon-gamma and interleukin-1 and higher Con-A-induced transformation rates of lymphocytes. Titres of CPV antibodies were significantly (p < 0.01) higher in dogs vaccinated and treated with PA either 10 days prior to or simultaneously with immunization. It is concluded that PA may be applied as a potent and safe adjuvant in vaccination of small animals and additionally, it provides enhancement of non-specific antibacterial and antiviral resistance of the organism.
authors.affiliation: Department of Epizootiology, Agriculture Academy, Olsztyn, Poland.
authors.forename: A K
authors.initials: AK
authors.lastname: Siwicki
authors.forename: J
authors.initials: J
authors.lastname: Krzyzanowski
authors.forename: M
authors.initials: M
authors.lastname: Bartoszcze
authors.forename: Z
authors.initials: Z
authors.lastname: Mizak
authors.forename: S
authors.initials: S
authors.lastname: Paluch
authors.forename: S
authors.initials: S
authors.lastname: Szmigielski
authors.forename: J
authors.initials: J
authors.lastname: Jeljaszewicz
authors.forename: G
authors.initials: G
authors.lastname: Pulverer
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D001770:Blood Bactericidal Activity; D004283:Dog Diseases / Q000276:immunology / Q000517:prevention & control*; D004285:Dogs; D008297:Male; D010322:Parvoviridae Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D017993:Parvovirus, Canine; D010587:Phagocytosis; D011424:Propionibacterium; D014765:Viral Vaccines
chemical_list: D000276:Adjuvants, Immunologic; D014765:Viral Vaccines