title: [Malignant changes in laryngeal papilloma with 13 case reports].
abstract: The 13 cases of malignant changes in 43 cases of laryngeal papilloma are reported. The rate of malignant change was 30. 2%. Laryngeal papilloma with epithelial atypia has proclaimed the onset of carcinoma. Therefore, high attention should be paid on its treatment. The safe margin on the operation of the malignant change case should be kept above 0.5 cm and radiation should be followed after the operation. It was invalid by using only radiation treatment. The pathogenesis and diagnosis of malignant change in laryngeal papillomas were also discussed in this article.
authors.affiliation: Head-Neck Surgical Department, Third Hospital of Harbin Medical University.
authors.forename: N
authors.initials: N
authors.lastname: Zhang
authors.forename: S
authors.initials: S
authors.lastname: Jia
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D013517:Otorhinolaryngologic Surgical Procedures / Q000379:methods; D010212:Papilloma / Q000473:pathology* / Q000601:surgery; D011230:Precancerous Conditions / Q000473:pathology* / Q000601:surgery