title: Nicotine metabolism defect reduces smoking.
authors.forename: M L
authors.initials: ML
authors.lastname: Pianezza
authors.forename: E M
authors.initials: EM
authors.lastname: Sellers
authors.forename: R F
authors.initials: RF
authors.lastname: Tyndale
mesh_terms: D000483:Alleles; D001189:Aryl Hydrocarbon Hydroxylases; D065637:Cytochrome P-450 CYP2A6; D003577:Cytochrome P-450 Enzyme System / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D005787:Gene Frequency; D006801:Humans; D006899:Mixed Function Oxygenases / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D009538:Nicotine / Q000378:metabolism*; D012907:Smoking / Q000235:genetics*; D014029:Tobacco Use Disorder / Q000201:enzymology*
chemical_list: D009538:Nicotine; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D001189:Aryl Hydrocarbon Hydroxylases; D065637:Cytochrome P-450 CYP2A6