Cutaneous ulceration: an unusual sign of methotrexate toxicity--first report in a patient without psoriasis.
OBJECTIVE
To describe a case of skin ulcer related to methotrexate toxicity.


METHODS
A 67-year-old white man with seronegative arthralgia developed recurrent skin ulcer concurrent with 3-year treatment with methotrexate 5 mg daily. The skin ulcer resolved on discontinuation of methotrexate.


CONCLUSIONS
To the best of our knowledge, this is the first reported case of skin ulcer believed to be induced by methotrexate in a patient without psoriasis.


CONCLUSIONS
Skin ulceration should be added to the list of possible toxic adverse effects of methotrexate, not only in psoriatic patients but also in those without psoriasis.
Ben-Amitai
D
D
Pediatric Dermatology Unit, Schneider Children's Medical Center of Israel, Tel Aviv University, Petah Tiqva, Israel.
Hodak
E
E
David
M
M
D000368:Aged; D018501:Antirheumatic Agents / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D012883:Skin Ulcer / Q000139:chemically induced* / Q000188:drug therapy
D018501:Antirheumatic Agents; D008727:Methotrexate