title: Diagnostic thoracic-computed tomography in radiotherapy for loco-regional recurrent breast carcinoma.
abstract: OBJECTIVE
  This study was initiated to evaluate whether pretreatment diagnostic thoracic CT scan was useful for patients with loco-regional recurrent breast carcinoma, and to assess its impact on the design of radiotherapeutic treatment.
  
  
  METHODS
  Between March 1991 and January 1997, 44 patients underwent thoracic CT examination with contrast material before the consideration of radiotherapy for their isolated loco-regional recurrent breast carcinoma. The CT radiographs were prospectively reviewed for additional findings clinically undetected by prior physical examination and plain-chest radiograph. The changes made in treatment design and dosage of radiation as a result of CT findings were recorded for analysis. The correlation between prognostic indicators and the CT findings was also studied.
  
  
  RESULTS
  Twenty-two of 44 (50%) patients were found to have additional abnormalities detected only after thoracic CT examinations were performed. The strategy of radiation therapy was altered in 17 of 22 (77%) patients as a result. Patients with shorter disease-free interval (p = 0.08) and multiple sites of recurrence (p = 0.05) tended to have greater numbers of findings on CT scan previously unsuspected. Thus, CT scan is a valuable guide to treating loco-regional recurrent disease.
  
  
  CONCLUSIONS
  Pretreatment diagnostic thoracic CT scan offers essential information that can alter treatment planning and thus optimize treatment strategy for a large proportion of patients with clinically isolated loco-regional recurrent breast carcinoma. In this population of patients we recommend that thoracic CT examination be considered before the initiation of radiation therapy.
authors.affiliation: Department of Radiation Oncology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan.
authors.forename: J C
authors.initials: JC
authors.lastname: Cheng
authors.forename: S H
authors.initials: SH
authors.lastname: Cheng
authors.forename: K J
authors.initials: KJ
authors.lastname: Lin
authors.forename: J J
authors.initials: JJ
authors.lastname: Jian
authors.forename: K Y
authors.initials: KY
authors.lastname: Chan
authors.forename: A T
authors.initials: AT
authors.lastname: Huang
mesh_terms: D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000532:radiotherapy*; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging* / Q000532:radiotherapy* / Q000556:secondary; D018276:Carcinoma, Medullary / Q000000981:diagnostic imaging* / Q000532:radiotherapy* / Q000556:secondary; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging* / Q000473:pathology / Q000532:radiotherapy*; D009367:Neoplasm Staging; D011446:Prospective Studies; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods*