title: High incidence of hypoglycemic episodes with neurologic manifestations in children with insulin dependent diabetes mellitus.
abstract: Hypoglycemia is a serious frequent complication of insulin therapy in type 1 diabetes.
  
  
  METHODS
  We surveyed 139 IDDM patients.
  
  
  RESULTS
  Forty-four patients (32%) reported at least one severe hypoglycemic episode. All patients with severe hypoglycemia experienced neurological manifestations. Symptoms included confusion and abnormal behavior, convulsions, coma, transient hemiparesis and one case of permanent hemiparesis. Most episodes occurred at night or during morning hours. 44% of episodes were related to delayed meal or snack, 11% to excess insulin administration and 13% to extra physical activity. HbA1c was significantly lower in patients with severe hypoglycemia compared with diabetic controls (7.33 +/- 1.09% and 9.45 +/- 4.32%, respectively).
authors.affiliation: Juvenile Diabetes Unit, Rambam Medical Center, Haifa, Israel.
authors.forename: N
authors.initials: N
authors.lastname: Shehadeh
authors.forename: J
authors.initials: J
authors.lastname: Kassem
authors.forename: I
authors.initials: I
authors.lastname: Tchaban
authors.forename: S
authors.initials: S
authors.lastname: Ravid
authors.forename: E
authors.initials: E
authors.lastname: Shahar
authors.forename: T
authors.initials: T
authors.lastname: Naveh
authors.forename: A
authors.initials: A
authors.lastname: Etzioni
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism; D002648:Child; D003221:Confusion / Q000209:etiology*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D015444:Exercise; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006429:Hemiplegia / Q000209:etiology; D006801:Humans; D007003:Hypoglycemia / Q000453:epidemiology* / Q000209:etiology; D015994:Incidence; D007328:Insulin / Q000009:adverse effects; D008297:Male; D012640:Seizures / Q000209:etiology*; D014474:Unconsciousness / Q000209:etiology*
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007328:Insulin