[Pathogenesis of osteoporosis and risk factors].
Osteoporosis is defined as a disease with low bone mineral density (BMD) and the increased probability for non-traumatic fractures in elderly. BMD in the elderly is theoretically determined by the BMD reached in younger era and the rate of bone loss in the later life. Both of peak bone mass and bone loss rate are known to be affected by environmental factors as well as genetic factors. In addition, both factors are assumed to interact each other. Prevention and treatment of osteoporosis would be fascilitated by understanding both of these factors.
Hosoi
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Dept. of Geriatrics, Faculty of Med., Univ. of Tokyo.
D000368:Aged; D005260:Female; D006801:Humans; D008875:Middle Aged; D010024:Osteoporosis / Q000209:etiology*; D012307:Risk Factors