title: Metabolic activation of dopamine o-quinones to o-semiquinones by NADPH cytochrome P450 reductase may play an important role in oxidative stress and apoptotic effects.
abstract: In this study, it is shown that considerable evidence for the possible pathway by which dopamine o-quinone, o-quinone and aminochrome can be activated metabolically by NADPH cytochrome P450 reductase to high reactive semiquinones. These findings were discussed from a mechanistic standpoint as well as in terms of potential physiological implications of dopamine o-quinones and o-semiquinones' concerted action in oxidative stress and apoptotic events.
authors.affiliation: Unit for Biochemical Toxicology, Wallenberg Laboratory, Stockholm University, Sweden. juan.segura-aguilar@tuborg.biokemi.su.se
authors.forename: J
authors.initials: J
authors.lastname: Segura-Aguilar
authors.forename: D
authors.initials: D
authors.lastname: Metodiewa
authors.forename: C J
authors.initials: CJ
authors.lastname: Welch
mesh_terms: D000818:Animals; D017209:Apoptosis; D001711:Biotransformation; D016466:CHO Cells; D006224:Cricetinae; D004298:Dopamine / Q000031:analogs & derivatives* / Q000378:metabolism; D009251:NADPH-Ferrihemoprotein Reductase / Q000502:physiology*; D018384:Oxidative Stress
chemical_list: C104705:dopamine quinone; D009251:NADPH-Ferrihemoprotein Reductase; D004298:Dopamine