Cyclophosphamide in diffuse lung damage.
Some cyclophosphamide toxic effects on lung tissue are presented. Cyclophosphamide metabolism, pathogenesis of lung damage and morphological lung tissue changes caused by that agent were characterized. Attention was focused on BAL evaluation as a useful method in the monitoring of lung tissue damage degree.
Musiatowicz
B
B
Department of Pathological Anatomy, Medical Academy of Białystok.
Sulkowska
M
M
Sulik
M
M
Famulski
W
W
Dziecioł
J
J
Sobaniec-Lotowska
M
M
Baltaziak
M
M
Arciuch
L
L
Rółkowski
R
R
Jabłońska
E
E
D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects / Q000378:metabolism / Q000633:toxicity*; D001711:Biotransformation; D003520:Cyclophosphamide / Q000009:adverse effects / Q000378:metabolism / Q000633:toxicity*; D006801:Humans; D008168:Lung / Q000187:drug effects* / Q000648:ultrastructure; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000473:pathology; D051381:Rats
D018906:Antineoplastic Agents, Alkylating; D003520:Cyclophosphamide