title: Clonidine does not impair redistribution hypothermia after the induction of anesthesia.
abstract: Clonidine is commonly given for premedication, and it impairs normal thermoregulatory responses to warm and cold stimuli while depressing sympathetic tone. We studied the effect of premedication by clonidine on redistribution hypothermia induced by the induction of anesthesia. Sixteen ASA physical status I or II patients were randomly assigned to receive either clonidine 150 micrograms or a placebo. Anesthesia was induced 45 min later by thiopental, fentanyl, and vecuronium i.v. and was maintained by the administration of 0.6% isoflurane. We monitored central core (tympanic) temperature and skin surface temperatures at the forearm and the fingertip during the 2 h after the induction of anesthesia before surgery. We estimated skin blood flow at the level of the forearm by using laser Doppler during the same period. The core temperature decreased comparably in the two groups of patients, from 37.1 +/- 0.2 degrees C to 35.3 +/- 0.4 degrees C and from 37.1 +/- 0.2 degrees C to 35.5 +/- 0.3 degrees C in the clonidine and placebo groups, respectively. The forearm-fingertip surface temperature gradient decreased similarly in the two groups. There was no evidence of cutaneous vasoconstriction. The laser Doppler index at the fingertip increased similarly in the two groups, as did the forearm-fingertip temperature gradient. We conclude that premedication with clonidine does not significantly impair the profile of central hypothermia induced by heat redistribution after the induction of anesthesia.
  
  
  CONCLUSIONS
  The induction of general anesthesia is associated with redistribution hypothermia. This study shows that premedication with oral clonidine does not worsen the decrease in core temperature resulting from general anesthesia.
authors.affiliation: Département d'Anesthésie Réanimation, Hôpital Tenon, Paris, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Bernard
authors.forename: J P
authors.initials: JP
authors.lastname: Fulgencio
authors.forename: L
authors.initials: L
authors.lastname: Delaunay
authors.forename: F
authors.initials: F
authors.lastname: Bonnet
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use*; D000328:Adult; D000768:Anesthesia, General / Q000009:adverse effects*; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects*; D003000:Clonidine / Q000627:therapeutic use*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007035:Hypothermia / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010919:Placebos; D012881:Skin Temperature / Q000187:drug effects
chemical_list: D000316:Adrenergic alpha-Agonists; D010919:Placebos; D003000:Clonidine