title: Intracortical functional heterogeneity in area striate during penicillin-induced spikes in rabbits.
abstract: The generation and spread of epileptiform activity within the cortex depend on the functional and anatomical relationships between the focus and its surrounding area. These processes are not completely understood. Thus intracortical current-source-density analysis (CSD) was performed in six rabbits in order to investigate this functional relationship. Electric potential was measured perpendicular to the cortical surface by means of two 16-channel probes, and CSD was calculated within the focus and at various distances of up to 5 mm. The cortical areas surrounding the focus could be subdivided into three regions. The region up to 3 mm from the focus showed similar activity but beyond 4.5 mm no characteristic functional relationship was found with regard to the epileptiform events within the focus. Within the region 3.5-4.5 mm, however, mainly supragranular cells seem to contribute to the electric potential measured at the cortical surface and within the extracellular space. They were activated simultaneously with the initiation of focal spike generation. Taking into account the distribution of the electric potential and the results of CSD analysis, these cells seem mainly involved in the inhibition of the horizontal spread of spike activity.
authors.affiliation: Institute of Pathophysiology, Klinikum der Friedrich Schiller, Universität, Jena, Germany. ime@rz.unijena.de
authors.forename: M
authors.initials: M
authors.lastname: Eiselt
authors.forename: U
authors.initials: U
authors.lastname: Zweiner
authors.forename: H
authors.initials: H
authors.lastname: Wagner
authors.forename: T
authors.initials: T
authors.lastname: Schindler
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D002540:Cerebral Cortex / Q000503:physiopathology*; D004594:Electrophysiology / Q000379:methods; D004827:Epilepsy / Q000139:chemically induced / Q000503:physiopathology*; D010406:Penicillins; D011817:Rabbits
chemical_list: D010406:Penicillins