Synthesis and preliminary antileukemic studies of cyclic mitoguazone analogues.
Analogues of mitoguazone bearing a terminal amidino group as a part of the seven-membered ring of 1,3-diazepine and six-membered ring of pyrimidine were prepared in order to evaluate in vivo antileukemic action towards L1210 leukemia in mice. Preliminary pharmacological screening showed that the investigated compounds increase the life span (T/C%) of the treated mice in comparison with the untreated animals. The strongest antineoplastic effect was exhibited by compound 8.
Krezel
I
I
Department of Pharmaceutical Chemistry and Drug Analysis, Medical Academy, Lódź, Poland.
Graczyk
J
J
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D008811:Mice, Inbred DBA; D008935:Mitoguazone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000627:therapeutic use; D015394:Molecular Structure
D000970:Antineoplastic Agents; D008935:Mitoguazone