title: [Spasmolytic effects of crebanine on isolated gallbladder and Oddi's sphincter in vitro].
abstract: The study has shown that the contraction induced by histamine, Ca2+ and K+ in the biliary system of guinea-pigs is antagonized by crebanine in vitro. The antagonism presents a depression of the maximal response of the dose-response curve for the agonists in a non-competitive manner. Crebanine blocks the release of calcium from intracellular storage on isolated gall-bladder. The spontaneous activity of the oddi's sphincter in vitro is inhibited by crebanine. The initial phasic and the ionic contraction induced by K+ (40 mmol/L) in the isolated oddi's sphincters of guinea-pigs are inhibited by crebanine.
authors.affiliation: Department of Pharmacology, Kunming Medical College.
authors.forename: H
authors.initials: H
authors.lastname: Li
authors.forename: C
authors.initials: C
authors.lastname: Su
authors.forename: F
authors.initials: F
authors.lastname: Wang
mesh_terms: D000818:Animals; D001060:Aporphines / Q000494:pharmacology*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D005260:Female; D005704:Gallbladder / Q000187:drug effects*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D009803:Sphincter of Oddi / Q000187:drug effects*
chemical_list: D001060:Aporphines; D002121:Calcium Channel Blockers; C061009:crebanine