title: Role of injury of gastric parietal vessels by immunocomplexes in the mechanism of gastric mucosal lesion in portal hypertension with cirrhosis.
abstract: The present experiment employed the immunohistochemical technique and morphological observation to investigate the expression and distribution of C3, C4, IgG, IgE 5-HT in portal hypertensive pigs with pathological change of gastric mucosa and gastric parietal vessels. The wall of gastric mucosal mirco-vessels in portal hypertensive pigs had a positive or strong positive reaction of C3, C4, IgG, IgE and 5-HT with obvious injury of gastric mucosa normal pigs imparted negative or feeble positive reaction, suggesting that during portal hypertension, the gastric mucosal micro-vessels has deposit of immunocomplexes resulting in the injury of the micro-vessels. It might be a factor involved in the pathogenesis of the gastric mucosal lesion during portal hypertension with cirrhosis.
authors.affiliation: Department of General Surgery, Tongji Hospital, Tongji Medical University, Wuhan.
authors.forename: C
authors.initials: C
authors.lastname: Mba Mba
authors.forename: Z
authors.initials: Z
authors.lastname: Yang
mesh_terms: D000818:Animals; D000936:Antigen-Antibody Complex / Q000378:metabolism*; D002196:Capillaries / Q000276:immunology; D003176:Complement C3 / Q000378:metabolism; D003181:Complement C4 / Q000378:metabolism; D005753:Gastric Mucosa / Q000276:immunology / Q000473:pathology*; D006975:Hypertension, Portal / Q000150:complications / Q000473:pathology*; D007074:Immunoglobulin G / Q000378:metabolism; D008106:Liver Cirrhosis, Experimental / Q000150:complications / Q000473:pathology*; D013270:Stomach / Q000098:blood supply*; D013552:Swine
chemical_list: D000936:Antigen-Antibody Complex; D003176:Complement C3; D003181:Complement C4; D007074:Immunoglobulin G