title: [Evaluation of the efficiency and safety of the loratadine with pseudoephedrine combination drug in treatment of seasonal allergic rhinitis].
abstract: The aim of the study was to assess efficacy and safety of 5 mg loratadine/120 mg pseudoephedrine combination drug in patients with seasonal allergic rhinitis. 30 patients allergic to grass pollen were treated with the new drug (Clarinase) twice a day in 15-day study during grass pollen seasonal. Nasal an non-nasal symptoms were evaluated for efficacy. Loratadine/pseudoephedrine combination effected a significant decrease in total symptoms score as well as individual evaluated symptoms score: nasal stuffiness, itching and discharge, sneezing, eye itching, tearing and redness of the eyes. The treatments was well tolerated. No serious side effects were noticed. The incidence of mild sedation, dry mouth, insomnia and nervousness was only 3 to 7 percent. 5 mg loratadine plus 120 mg pseudoephedrine was safe and effective in relieving the symptoms of allergic rhinitis.
authors.affiliation: Poradni Alergologicznej Przychodni Przyszpitalnej CSK AM w Warszawie.
authors.forename: E
authors.initials: E
authors.lastname: Zawisza
authors.forename: A
authors.initials: A
authors.lastname: Lipiec
authors.forename: P
authors.initials: P
authors.lastname: Rapiejko
mesh_terms: D000293:Adolescent; D000328:Adult; D018926:Anti-Allergic Agents / Q000627:therapeutic use*; D004338:Drug Combinations; D004809:Ephedrine / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D017336:Loratadine / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D014663:Nasal Decongestants / Q000009:adverse effects / Q000627:therapeutic use*; D054199:Pseudoephedrine; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy*; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
chemical_list: D018926:Anti-Allergic Agents; D004338:Drug Combinations; D014663:Nasal Decongestants; C060049:Sch 434; D017336:Loratadine; D054199:Pseudoephedrine; D004809:Ephedrine
vernacular_title: Ocena skuteczności i bezpieczeństwa preparatu złozonego loratadyny z pseudoefedryna w leczeniu sezonowego alergicznego zapalenia błony śluzowej nosa.