title: Enhancement of NO production in activated macrophages in vivo by an antimalarial crude drug, Dichroa febrifuga.
abstract: The effect of an antimalarial crude drug, Dichroafebrifuga Lour. on nitric oxide (NO) production in bacillus Calmette Guérin-induced mouse peritoneal macrophages activated by lipopolysaccharide was investigated. The NO production was significantly enhanced by an oral administration of a MeOH extract of D. febrifuga. Febrifugine (1) was isolated as the main active compound, and the activation was dose-dependent in the dosage range of 0.1-1 mg/kg/day.
authors.affiliation: Department of Pharmacognosy, and Experimental Station for Medicinal Plant Studies, Faculty of Pharmaceutical Sciences, Tohoku University, Aoba-yama, Aoba-ku, Sendai 980-77, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Murata
authors.forename: F
authors.initials: F
authors.lastname: Takano
authors.forename: S
authors.initials: S
authors.lastname: Fushiya
authors.forename: Y
authors.initials: Y
authors.lastname: Oshima
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D002681:China; D066298:In Vitro Techniques; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D008813:Mice, Inbred ICR; D009569:Nitric Oxide / Q000096:biosynthesis*; D010880:Piperidines; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011799:Quinazolines / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000962:Antimalarials; D010880:Piperidines; D010936:Plant Extracts; D011799:Quinazolines; D009569:Nitric Oxide; C001207:febrifugine