[Factor XI deficiency, a new way of substitution: human purified concentrates].
Case report of a 26-year-old patient, admitted for severe craniofacial trauma, with facial injuries and intracranial haemorrhage. Preoperative tests showed an aPTT = 64 s (control = 29 s), rapidly recognized as being caused by a major constitutional factor XI deficiency (0.06 Ul.mL-1). Considering the neurological risk and the indication for surgery, concentrates of factor XI were administered at a dosage of 25 Ul.kg-1. This treatment was associated with a biological normalization and uneventful surgery. In patients experiencing a factor XI deficiency, the use of fresh frozen plasma will probably decrease and only administered in emergency cases when factor XI concentrates are not available.
Blanchard
N
N
Jeanjean
P
P
Lepointe
F
F
Dieval
J
J
Ossart
M
M
D000328:Adult; D001778:Blood Coagulation Disorders / Q000517:prevention & control; D001930:Brain Injuries / Q000628:therapy; D005172:Factor XI / Q000032:analysis*; D005173:Factor XI Deficiency / Q000628:therapy*; D006801:Humans; D007430:Intraoperative Care / Q000379:methods; D008297:Male; D010314:Partial Thromboplastin Time; D010956:Plasmapheresis
D005172:Factor XI
Déficit en facteur XI, un nouveau moyen de substitution: les concentrés humains purifíes.