Prevention of diabetes in non-obese diabetic (NOD) mice by short-term and high-dose IGF-I treatment.
This report describes the results of IGF-I treatment in a NOD mouse colony with a high incidence of overt diabetes. The animals were treated with IGF-I 17.9 nmol/day at 28-41 days of age and 35.9 nmol/day at 42-69 days of age and observed up to 280 days of age. Three of 12 (25%) IGF-I-treated animals developed diabetes compared with 8 of 11 (73%) controls (P < 0.05). The severity of insulitis at the conclusion of the follow-up was less pronounced in non-diabetic treated animals than in non-diabetic controls. These data support previous findings that IGF-I treatment protects the pancreatic beta-cells from destruction by diabetic autoimmunity in NOD mice.
Kaino
Y
Y
Department of Pediatrics, Ehime University School of Medicine, Japan.
Hirai
H
H
Ito
T
T
Kida
K
K
D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000517:prevention & control*; D005260:Female; D007328:Insulin / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D016688:Mice, Inbred NOD
D007328:Insulin; D007334:Insulin-Like Growth Factor I