title: Incidence and risk factors of perioperative cerebral complications. Heart transplantation compared to coronary artery bypass grafting and valve surgery.
abstract: OBJECTIVE
  The aim of this study was to define the neurologic risk of heart transplantation compared to coronary artery bypass grafting (CABG) and valve surgery.
  
  
  METHODS
  A retrospective study.
  
  
  METHODS
  A university hospital.
  
  
  METHODS
  8001 patients undergoing heart transplantation, CABG and valve surgery.
  
  
  METHODS
  The incidences of perioperative central nervous system (CNS) complications were compared between different procedures. Risk factors were analysed using univariate and multivariate methods.
  
  
  RESULTS
  The overall incidence of CNS complications was 19.8% (78/393) in heart transplantation, 3.1% (176/5734) in elective CABG, 9.5% (161/1689) in elective valve surgery, 10.3% (15/146) in emergency CABG and 51.3% (20/39) in emergency valve surgery. Most powerful predictors of CNS complications were preoperative intra-aortic counterpulsation (IABP) in the heart transplantation group, age >65 years in the CABG group and preoperative use of catecholamine in the valve group.
  
  
  CONCLUSIONS
  CNS complications occur much more frequently after heart transplantation than elective CABG and valve surgery. The high incidence of CNS complications after emergency operations as well as preoperative catecholamine and IABP as powerful contributing factors suggest that preoperative cerebral hypoperfusion due to a compromised hemodynamic state facilitates postoperative CNS complications and this may partly explain the high incidence of CNS complications after heart transplantation.
authors.affiliation: Department of Anaesthesia, Heart and Diabetes Center Nordrhein-Westfalen, Ruhr University of Bochum, Bad Oeynhausen, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Inoue
authors.forename: J U
authors.initials: JU
authors.lastname: Lüth
authors.forename: D
authors.initials: D
authors.lastname: Pottkämper
authors.forename: K M
authors.initials: KM
authors.lastname: Strauss
authors.forename: K
authors.initials: K
authors.lastname: Minami
authors.forename: W
authors.initials: W
authors.lastname: Reichelt
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002395:Catecholamines / Q000009:adverse effects; D002560:Cerebrovascular Circulation / Q000187:drug effects; D002561:Cerebrovascular Disorders / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D016027:Heart Transplantation / Q000009:adverse effects*; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D007423:Intra-Aortic Balloon Pumping / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D002395:Catecholamines