title: [Evaluation of the reserve potential of the blood kallikrein-kinin system in healthy subjects].
abstract: The reserve potential of the blood kinin-producing activity and kallikrein inhibitors were assessed under conditions of a functional test (double local hypoxia of the upper limb) in 68 healthy volunteers aged 17-45 years. Three types of reactions of the studied components of the kallikrein-kinin system (KKS) were distinguished: concomitant (79.4%), kininase (5.9%), and kininogenesis (14.7%). The concomitant type was characterized by increased activity of all components of the system during the test, indicating its sufficient reserve potential. A drop of kinin production and increased activity of the inhibitory component of KKS in response to hypoxia reflect a low reserve potential of kininogenesis in subjects with the kininase type of KKS. An appreciable decrease of kallikrein inhibitor activity during the test in the presence of increased kininogenesis demonstrates the limited reserves of the inhibitory component of the kinin cascade in normal subjects with the kininogenesis type of KKS.
authors.forename: V V
authors.initials: VV
authors.lastname: Udut
authors.forename: G T
authors.initials: GT
authors.lastname: Kairov
authors.forename: A B
authors.initials: AB
authors.lastname: Karpov
authors.forename: E V
authors.initials: EV
authors.lastname: Borodulina
authors.forename: L M
authors.initials: LM
authors.lastname: V'iugova
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D016234:Kallikrein-Kinin System; D008297:Male; D008875:Middle Aged; D012016:Reference Values
vernacular_title: Otsenka rezervnykh vozmozhnosteĭ kallikrein-kininovoĭ sistemy krovi zdorovykh liudeĭ.