[Final results of the administration of biosynthetic growth hormone. Preliminary report].
From March, 1987 to November, 1995, we have included 89 growth hormone-deficient children for treatment for their low height with the biosynthetic growth hormone; 23 of them have concluded treatment. Without taking into account the etiological factor of their deficiency, 6 girls and 17 boys during different lapses had modified their initial height and the scores of the standard deviation as groups, range from 113.11 +/- 14.83 cm and -5.12 +/- 1.21 to 139.11 +/- 8.96 cm. and -2.68 +/- 1.17 in the girls, and from 128.46 +/- 12.49 cm and -4.13 +/- 1.35 to 158.61 +/- 6.47 cm and -1.76 +/- 0.9 in the boys, respectively. These results between the initial height and the score of the standard deviation compared with the final height and the standard deviation score, showed a statistically significant difference of p < 0.001 both in girls and boys. Two girls and 3 boys developed hypothyroidism during the treatment, without any other side effect. We concluded that early and prolonged biosynthetic growth hormone administration in growth hormone-deficient children might produce a final adult height similar to the normal population standards.
Mendoza-Morfín
F
F
Departamento Clínico de Endocrinología Pediátrica, Hospital General Centro Médico Nacional La Raza IMSS, México D.F.
Cárdenas-Tirado
H
H
Montero-González
P
P
Bravo-Ríos
L E
LE
Gutiérrez-Avila
C
C
Torres-Tamayo
M
M
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001827:Body Height; D002648:Child; D003627:Data Interpretation, Statistical; D005260:Female; D006130:Growth Disorders / Q000188:drug therapy*; D019382:Human Growth Hormone / Q000008:administration & dosage* / Q000172:deficiency*; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D012737:Sex Factors; D013997:Time Factors
D019382:Human Growth Hormone
Resultado final de la administración de hormona de crecimiento biosintética. Informe preliminar.