title: General stress transcription factor sigmaB and sporulation transcription factor sigmaH each contribute to survival of Bacillus subtilis under extreme growth conditions.
abstract: The general stress response of the bacterium Bacillus subtilis is controlled by the sigmaB transcription factor. Here we show that loss of sigmaB reduces stationary-phase viability 10-fold in either alkaline or acidic media and reduces cell yield in media containing ethanol. We further show that loss of the developmental transcription factor sigmaH also has a marked effect on stationary-phase viability under these conditions and that this effect is independent from the simple loss of sporulation ability.
authors.affiliation: Department of Food Science and Technology, University of California, Davis, California 95616, USA.
authors.forename: T A
authors.initials: TA
authors.lastname: Gaidenko
authors.forename: C W
authors.initials: CW
authors.lastname: Price
mesh_terms: D000891:Anti-Infective Agents, Local / Q000494:pharmacology; D001412:Bacillus subtilis / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D001426:Bacterial Proteins / Q000187:drug effects / Q000502:physiology*; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D015169:Colony Count, Microbial; D000431:Ethanol / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D012808:Sigma Factor / Q000187:drug effects / Q000502:physiology*; D013171:Spores, Bacterial / Q000235:genetics; D014157:Transcription Factors / Q000502:physiology*
chemical_list: D000891:Anti-Infective Agents, Local; D001426:Bacterial Proteins; C079011:SigB protein, Bacteria; D012808:Sigma Factor; D014157:Transcription Factors; D000431:Ethanol