title: Effect of thromboxane synthetase inhibitor on feline infectious peritonitis in cats.
abstract: Two cats with abdominal effusion and anorexia were diagnosed as feline infectious peritonitis (FIP). We tried to evaluate the effect of thromboxane (Tx) synthetase inhibitor, ozagrel hydrochloride, on the progression of symptoms and clinicopathologic data characteristic to FIP. After administration of Tx synthetase inhibitor, improvement of appetite and activity, decreases of peritoneal effusion, reduction of leukocyte number to normal level, and improvement of hyper gamma-globulinemia were found in 2 cats with FIP. These findings suggest that the vasculitis in FIP can be successfully treated with Tx synthetase inhibitor which inhibits platelet aggregation.
authors.affiliation: Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Watari
authors.forename: T
authors.initials: T
authors.lastname: Kaneshima
authors.forename: H
authors.initials: H
authors.lastname: Tsujimoto
authors.forename: K
authors.initials: K
authors.lastname: Ono
authors.forename: A
authors.initials: A
authors.lastname: Hasegawa
mesh_terms: D000818:Animals; D000855:Anorexia; D001201:Ascites / Q000209:etiology; D001772:Blood Cell Count / Q000187:drug effects; D002415:Cats; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D016766:Feline Infectious Peritonitis / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D008297:Male; D008689:Methacrylates / Q000627:therapeutic use*; D009919:Orchiectomy; D011860:Radiography, Abdominal / Q000662:veterinary; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D008689:Methacrylates; D013930:Thromboxane-A Synthase; C034364:ozagrel