title: [Hereditary spherocytosis associated with severe hypophosphatemia in patients recovering from aplastic crisis].
abstract: This is a report about two cases of hereditary spherocytosis complicated by severe hypophosphatemia, while recovering from aplastic crisis. Case #1: A 31-year-old male, who had jaundice and splenomegaly since the age of 15 and who has a son diagnosed with hemolytic anemia, was admitted because of fever lymphadenopathy, and jaundice. A diagnosis of hereditary spherocytosis was made based on microspherocytes observed in his peripheral blood smear. After admission, the anemia became more serious for a few days and he was considered suffering from bone marrow aplastic crisis. His serum phosphorus level fell to 0.5 mg/dl on the second day, but it rapidly returned to normal as reticulocyte counts rose. Case #2: A 29-year-old male with known transient jaundice and splenomegaly suffered from fever, anemia and jaundice, but recovered two weeks later. Laboratory examination revealed positive human Parvovirus B19 (HPV-B19) DNA, anti-HPV-19 IgM and IgG-antibody. His serum phosphorus level fell to 1.2 mg/dl on the eighth day, but it rose in the same manner as seen in case #1. The fall in serum phosphorus is probably due to its shift to the erythroblasts during erythroid hyperplasia.
authors.affiliation: Department of Hematology, Seirei Hamamatsu General Hospital.
authors.forename: N
authors.initials: N
authors.lastname: Sahara
authors.forename: S
authors.initials: S
authors.lastname: Tamashima
authors.forename: M
authors.initials: M
authors.lastname: Ihara
mesh_terms: D000328:Adult; D000741:Anemia, Aplastic / Q000209:etiology* / Q000821:virology*; D006801:Humans; D017674:Hypophosphatemia / Q000209:etiology*; D008297:Male; D010322:Parvoviridae Infections; D016732:Parvovirus B19, Human; D013103:Spherocytosis, Hereditary / Q000150:complications*