Two new ergostane-type steroidal lactones from Withania coagulans.
Two new withanolides (steroidal lactones) named coagulin F [27-hydroxy-14,20-epoxy-1-oxo-(22R)-witha-3,5,24-trienolide] (1) and coagulin G [17beta,27-dihydroxy-14,20-epoxy-1-oxo-(22R)-witha-2,5, 24-trienolide] (2) were isolated from the whole plant of Withania coagulans, and their structures were deduced by spectral analysis.
Atta-ur-Rahman
A
A
International Center for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.
Choudhary
M I
MI
Qureshi
S
S
Gul
W
W
Yousaf
M
M
D000107:Acetylation; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D004875:Ergosterol / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D007783:Lactones / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010154:Pakistan; D010946:Plants, Medicinal / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000935:Antifungal Agents; D007783:Lactones; C113223:coagulin F; C113224:coagulin G; D004875:Ergosterol