Inhaled nitric oxide improves exercise capacity in patients with severe heart failure and right ventricular dysfunction.
Fourteen cardiac transplant candidates were studied with cardiopulmonary exercise testing at baseline and while breathing nitric oxide (40 ppm). Oxygen consumption at the anaerobic threshold was improved by breathing nitric oxide in patients with pulmonary hypertension and in patients with an elevated left ventricular end-diastolic volume index.
Koelling
T M
TM
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA.
Kirmse
M
M
Di Salvo
T G
TG
Dec
G W
GW
Zapol
W M
WM
Semigran
M J
MJ
D000280:Administration, Inhalation; D015444:Exercise; D005080:Exercise Test / Q000187:drug effects; D005260:Female; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome; D018497:Ventricular Dysfunction, Right / Q000188:drug therapy* / Q000503:physiopathology
D009569:Nitric Oxide