Anti-apoptosis therapy: a way of treating neural degeneration?
Many degenerative diseases involve apoptotic cell death--can they be treated with apoptosis inhibitors, while protecting the normal physiological function of the rescued cells? Reason for optimism comes from a recent study of mutant flies with an analogue of the human degenerative disease retinitis pigmentosa.
Jacobson
M D
MD
Millennium Pharmaceuticals Inc., Cambridge, Massachusetts 02139-4815, USA. jacobson@mpi.com
D000818:Animals; D017209:Apoptosis; D002135:Calcium-Binding Proteins; D015853:Cysteine Proteinase Inhibitors / Q000502:physiology*; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics; D005136:Eye Proteins / Q000235:genetics / Q000502:physiology; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D009410:Nerve Degeneration / Q000517:prevention & control*; D010749:Phosphoprotein Phosphatases / Q000235:genetics / Q000502:physiology*; D012162:Retinal Degeneration / Q000517:prevention & control*; D012243:Rhodopsin; D014764:Viral Proteins / Q000235:genetics / Q000502:physiology*
D002135:Calcium-Binding Proteins; D015853:Cysteine Proteinase Inhibitors; D029721:Drosophila Proteins; D005136:Eye Proteins; D051034:Inhibitor of Apoptosis Proteins; D014764:Viral Proteins; C086430:inhibitor of apoptosis, Nucleopolyhedrovirus; C083315:ninaE protein, Drosophila; D012243:Rhodopsin; D010749:Phosphoprotein Phosphatases; C074643:rdgC protein, Drosophila