title: Hospital acquired native valve endocarditis: analysis of 22 cases presenting over 11 years.
abstract: OBJECTIVE
  To analyse hospital acquired infective endocarditis cases with respect to age, sex, clinical, laboratory, and echocardiographic features, predisposition, complications, surgery, mortality, and diagnostic criteria.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  Teaching hospital.
  
  
  METHODS
  A series of 200 patients with infective endocarditis presenting over 11 years, 168 with native valve infective endocarditis, of whom 22 acquired this infection in hospital.
  
  
  RESULTS
  22 (14%) of the 168 cases of native valve infection were hospital acquired. The most common pathogens were staphylococci (77%). Two thirds of patients had no cardiac predisposition; one third had end stage renal disease. The most common source of infection was vascular access sites (73%). Eleven patients died. In 11 cases, infective endocarditis was proven pathologically (six at necropsy, five during surgery) and analysis of these showed that 45% were classed as probable by the Beth Israel criteria, 73% as definite by the Duke criteria, and 91% as definite by our suggested modifications of the Duke criteria. Figures for the 11 cases not proven pathologically were 27%, 73%, and 91%, respectively. Five of the 22 cases (22%) were rejected by the Beth Israel criteria but none were rejected by the Duke criteria with or without our modifications.
  
  
  CONCLUSIONS
  Hospital acquired infective endocarditis is difficult to diagnose. The Duke criteria have improved diagnostic sensitivity and our modifications have improved it further. Mortality is high but has been reduced by surgery. This serious infection could, in many cases, be prevented by improved care of intravascular lines and prompt removal when obviously infected.
authors.affiliation: Division of Infection, United Medical and Dental School, St Thomas's Hospital, London, UK.
authors.forename: C C
authors.initials: CC
authors.lastname: Lamas
authors.forename: S J
authors.initials: SJ
authors.lastname: Eykyn
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002404:Catheterization; D003428:Cross Infection / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality; D004697:Endocarditis, Bacterial / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D017678:Sex Distribution; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality