title: [Clinical case of the month. Galloping nephropathy in a patient with type 2 diabetes].
abstract: We report the case of a patient with insulin-requiring type 2 diabetes who exhibited a rapid deterioration of his renal function leading to haemodialysis in a few months. Various diagnosis were considered to explain this rapid deterioration, excluding diabetic nephropathy as major etiology. The exploration, especially renal biopsy, demonstrated the presence of a glomerulonephritis due to the deposition of immune complexes associated to active hepatitis C rather than diabetic glomerulosclerosis. A treatment with interferon-alpha allowed to partially restore renal function, this recovery permitting the interruption of hemodialysis, with a current follow-up of more than 6 months.
authors.affiliation: Département de Médecine, Université de Liège.
authors.forename: J C
authors.initials: JC
authors.lastname: Philips
authors.forename: A J
authors.initials: AJ
authors.lastname: Scheen
authors.forename: E
authors.initials: E
authors.lastname: Firre
authors.forename: M
authors.initials: M
authors.lastname: Robin
authors.forename: P
authors.initials: P
authors.lastname: Cambier
authors.forename: P J
authors.initials: PJ
authors.lastname: Lefèbvre
mesh_terms: D000328:Adult; D000936:Antigen-Antibody Complex / Q000032:analysis; D000998:Antiviral Agents / Q000627:therapeutic use; D001706:Biopsy; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003928:Diabetic Nephropathies / Q000175:diagnosis; D005500:Follow-Up Studies; D005921:Glomerulonephritis / Q000276:immunology / Q000473:pathology / Q000628:therapy / Q000821:virology*; D016174:Hepacivirus / Q000276:immunology; D006526:Hepatitis C / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use; D008297:Male; D006435:Renal Dialysis
chemical_list: D000936:Antigen-Antibody Complex; D000998:Antiviral Agents; D016898:Interferon-alpha
vernacular_title: Le cas clinique du mois. Une néphropathie galopante chez un patient diabétique de type 2.