Dental caries susceptibility in mice is closely linked to the H-2 region on chromosome 17.
The generation of dental caries in humans is thought to be regulated by many intrinsic and social factors. In this study, we examined the effect of MHC on susceptibility to dental caries in mice. The mean carious score of BALB.K/Ola, a H-2 congenic strain in which the H-2 region derived from C3H/HeJ (H-2(k/k)) is introduced into BALB/cJ (H-2(d/d)), was markedly reduced as compared with that of its recipient strain (BALB/cJ). Mating experiments confirmed a strong genetic linkage between H-2 haplotype and caries susceptibility. These results demonstrate that one of the genetic factors of the susceptibility in the mouse is mapped within the H-2 region. This finding of a host genetic factor influencing the generation of dental caries will help in developing clinical preventive strategies.
Suzuki
N
N
Department of Pedodontics, Nihon University School of Dentistry at Matsudo, Japan.
Kurihara
Y
Y
Kurihara
Y
Y
D000818:Animals; D002874:Chromosome Mapping; D002875:Chromosomes / Q000235:genetics*; D003731:Dental Caries / Q000209:etiology / Q000235:genetics / Q000382:microbiology; D003733:Dental Caries Susceptibility / Q000235:genetics*; D004037:Diet, Cariogenic; D005260:Female; D008040:Genetic Linkage; D006183:H-2 Antigens / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D008285:Major Histocompatibility Complex / Q000235:genetics; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008815:Mice, Inbred Strains; D013295:Streptococcus mutans / Q000502:physiology
D006183:H-2 Antigens