title: Subgingival microflora associated with nifedipine-induced gingival overgrowth.
abstract: The purpose of this study was to examine the composition of subgingival plaque of 140 periodontal lesions in 35 patients with cardiovascular disorders who were administered nifedipine and manifested nifedipine-induced gingival overgrowth (GO). Age was inversely associated with the GO. Plaque index and bleeding index showed a significant association with GO, while nifedipine dosage and duration of nifedipine therapy were not found to be significant predictors of GO. The gingival inflammation as expressed in the logistic regression model by the interaction term color x tone was found to be significantly associated with the GO. Statistically significant differences between the groups of comparable probing depth and different degrees of GO were detected for Propionibacterium acnes, Capnocytophaga gingivalis, Capnocytophaga ochracea, Capnocytophaga sputigena, Bacteroides gracilis, Fusobacterium mortiferum, Fusobacterium nucleatum, Fusobacterium varium and Selenomonas sputigena in deep and enlarged lesions. Significantly more frequently isolated were the bacterial species Eubacterium alactolyticum, Campylobacter concisus, C. gingivalis, C. ochracea, C. sputigena, F. mortiferum, F. nucleatum, and F. varium from the more enlarged lesions (GO >3).
authors.affiliation: Department of Periodontology, School of Dental Medicine, University of Athens, Greece.
authors.forename: M
authors.initials: M
authors.lastname: Nakou
authors.forename: J J
authors.initials: JJ
authors.lastname: Kamma
authors.forename: A
authors.initials: A
authors.lastname: Andronikaki
authors.forename: F
authors.initials: F
authors.lastname: Mitsis
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001438:Bacteroidaceae / Q000145:classification / Q000302:isolation & purification; D001439:Bacteroides / Q000302:isolation & purification; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000009:adverse effects*; D002167:Campylobacter / Q000302:isolation & purification; D002206:Capnocytophaga / Q000145:classification / Q000302:isolation & purification; D003773:Dental Plaque / Q000382:microbiology*; D003774:Dental Plaque Index; D005051:Eubacterium / Q000302:isolation & purification; D005260:Female; D005544:Forecasting; D005673:Fusobacterium / Q000145:classification / Q000302:isolation & purification; D016967:Fusobacterium nucleatum / Q000302:isolation & purification; D005881:Gingiva / Q000382:microbiology*; D005884:Gingival Hemorrhage / Q000473:pathology; D019214:Gingival Overgrowth / Q000139:chemically induced* / Q000382:microbiology / Q000473:pathology; D005888:Gingival Pocket / Q000473:pathology; D005891:Gingivitis / Q000139:chemically induced; D006090:Gram-Negative Bacteria / Q000145:classification*; D006094:Gram-Positive Bacteria / Q000145:classification*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage / Q000009:adverse effects*; D010512:Periodontal Index; D011425:Propionibacterium acnes / Q000302:isolation & purification
chemical_list: D002121:Calcium Channel Blockers; D009543:Nifedipine