title: Transcriptional control: Tat cofactors and transcriptional elongation.
abstract: HIV-1 gene expression requires the transactivator Tat, which stimulates viral transcript elongation. Recent results show that two cellular cyclin-dependent kinases, which phosphorylate the carboxy-terminal domain of the RNA polymerase II large subunit, contact Tat and contribute to the control of transcriptional elongation.
authors.affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
authors.forename: K
authors.initials: K
authors.lastname: Yankulov
authors.forename: D
authors.initials: D
authors.lastname: Bentley
mesh_terms: D000818:Animals; D015696:Gene Products, tat / Q000502:physiology*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D010441:Peptide Chain Elongation, Translational / Q000235:genetics; D010445:Peptide Elongation Factors / Q000502:physiology; D014158:Transcription, Genetic / Q000502:physiology*; D054322:tat Gene Products, Human Immunodeficiency Virus
chemical_list: D015696:Gene Products, tat; D010445:Peptide Elongation Factors; D054322:tat Gene Products, Human Immunodeficiency Virus