Blockade of alpha 4 beta 1-integrin-fibronectin adhesive interactions prevents chronic allograft rejection in sensitized recipients.
Coito
A J
AJ
Department of Surgery, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Korom
S
S
Hancock
W W
WW
Kupiec-Weglinski
J W
JW
D017398:Alternative Splicing; D000595:Amino Acid Sequence; D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects / Q000276:immunology*; D005353:Fibronectins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis / Q000737:chemistry; D014644:Genetic Variation; D006084:Graft Rejection / Q000276:immunology* / Q000517:prevention & control*; D016027:Heart Transplantation / Q000276:immunology*; D039041:Integrin alpha4beta1; D016023:Integrins / Q000037:antagonists & inhibitors* / Q000276:immunology; D008297:Male; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000276:immunology / Q000494:pharmacology*; D016133:Polymerase Chain Reaction; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D017207:Rats, Sprague-Dawley; D016201:Receptors, Lymphocyte Homing / Q000037:antagonists & inhibitors* / Q000276:immunology; D016029:Receptors, Very Late Antigen / Q000276:immunology; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000737:chemistry; D016038:Skin Transplantation / Q000276:immunology*; D016042:Transplantation, Heterotopic; D014184:Transplantation, Homologous
D005353:Fibronectins; D039041:Integrin alpha4beta1; D016023:Integrins; D010446:Peptide Fragments; D016201:Receptors, Lymphocyte Homing; D016029:Receptors, Very Late Antigen; D011994:Recombinant Proteins