Steroidal saponins from the underground parts of Ruscus aculeatus and their cytostatic activity on HL-60 cells.
Phytochemical examination of the underground parts of Ruscus aculeatus has been undertaken as part of systematic study of plants of the Liliaceae. Six new spirostanol saponins and five new furostanol saponins were isolated, and their structures were assigned on the basis of spectroscopic analysis, including two-dimensional NMR techniques, and hydrolysis. Ruscogenin diglycoside with three acetyl groups attached to the inner galactosyl moiety and its corresponding 26-glucosyloxyfurostanol saponin showed cytostatic activity on leukemia HL-60 cells.
Mimaki
Y
Y
School of Pharmacy, Tokyo University of Pharmacy and life Science, Japan.
Kuroda
M
M
Kameyama
A
A
Yokosuka
A
A
Sashida
Y
Y
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D019668:Liliaceae / Q000737:chemistry*; D008969:Molecular Sequence Data; D018517:Plant Roots / Q000737:chemistry; D012503:Saponins / Q000302:isolation & purification* / Q000494:pharmacology; D013057:Spectrum Analysis; D013256:Steroids / Q000302:isolation & purification* / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D013256:Steroids