title: Structural and functional changes in skeletal muscle in anorexia nervosa.
abstract: Protein-energy malnutrition in anorexia nervosa is an under-recognised cause of muscle dysfunction. To characterise the skeletal myopathy that occurs in patients with severe anorexia nervosa, muscle function and structure were comprehensively examined in eight young adult female patients with severe (40%) self-induced weight loss. All of the patients showed impaired muscle function on strength and exercise measurement. The maximum voluntary contraction force for the patient group was significantly less than predicted values. Electromyography revealed myopathy in five of the patients, four of whom also had electro-physiological evidence of neuropathy. However, muscle biopsy specimens consistently showed myopathic changes with severe type 2 fibre atrophy but with no evidence of neuropathic changes. Ultrastructurally, there was separation and segmental loss of myofibrils and most biopsy samples contained abundant glycogen granules; we have previously reported that one of the most consistent biochemical abnormalities in these patients is impaired ischaemic lactate responses to forearm exercise. The result of severe protein-energy malnutrition on the musculo-skeletal system is a metabolic myopathy. Although the patients admitted to a variety of abnormal dieting behaviours, such as over-exercising and self-induced vomiting, no association was found between any of these and quantitative histological changes in the muscle biopsy samples. It is recommended that myopathy in anorexia nervosa be treated by instituting an appropriate refeeding programme.
authors.affiliation: Department of Psychiatry, Institute of Psychiatry, London, UK.
authors.forename: D M
authors.initials: DM
authors.lastname: McLoughlin
authors.forename: E
authors.initials: E
authors.lastname: Spargo
authors.forename: W S
authors.initials: WS
authors.lastname: Wassif
authors.forename: D J
authors.initials: DJ
authors.lastname: Newham
authors.forename: T J
authors.initials: TJ
authors.lastname: Peters
authors.forename: P L
authors.initials: PL
authors.lastname: Lantos
authors.forename: G F
authors.initials: GF
authors.lastname: Russell
mesh_terms: D000328:Adult; D000856:Anorexia Nervosa / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D001706:Biopsy; D002400:Cathartics; D004032:Diet; D005260:Female; D006801:Humans; D007537:Isometric Contraction; D018656:Muscle Fibers, Fast-Twitch / Q000473:pathology; D018908:Muscle Weakness / Q000209:etiology* / Q000473:pathology; D018482:Muscle, Skeletal / Q000473:pathology*; D009133:Muscular Atrophy / Q000209:etiology* / Q000473:pathology; D005082:Physical Exertion; D011502:Protein-Energy Malnutrition / Q000209:etiology / Q000473:pathology; D019966:Substance-Related Disorders; D014839:Vomiting
chemical_list: D002400:Cathartics