Polygenic control of the expression of biological activities of an antitumor polysaccharide, lentinan.
Genetic studies were carried out on two in vivo responses of lentinan, delayed type-acute phase responses (DT-APR) and vascular dilation and hemorrhage (VDH). Linkage analyses showed that DT-APR was controlled by two recessive genes, ltnr1 and ltnr2, which were mapped on chromosome 3 and 11, respectively. VDH was also found to be controlled by polygenes. One dominant major gene, Ltnr3, and three dominant minor genes, Ltnr4, Ltnr5, and Ltnr6, were mapped on chromosomes 6, 9, 15 and 16, respectively.
Maeda
Y Y
YY
Department of Laboratory Animal Science, The Tokyo Metropolitan Institute of Medical Science, Japan. maeda@rinshoken.or.jp
Takahama
S
S
Kohara
Y
Y
Yonekawa
H
H
D000210:Acute-Phase Reaction / Q000209:etiology / Q000235:genetics / Q000276:immunology; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002874:Chromosome Mapping; D005799:Genes, Dominant; D005802:Genes, MHC Class II; D005808:Genes, Recessive; D008040:Genetic Linkage; D006470:Hemorrhage / Q000209:etiology / Q000235:genetics / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000209:etiology / Q000235:genetics / Q000276:immunology; D007912:Lentinan / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D013045:Species Specificity; D014664:Vasodilation / Q000187:drug effects / Q000235:genetics / Q000276:immunology
D000970:Antineoplastic Agents; D007912:Lentinan