title: Coronary artery stenoses: assessment with contrast-enhanced electron-beam CT and axial reconstructions.
abstract: OBJECTIVE
  To evaluate the usefulness of electron-beam computed tomography (CT) for identification of coronary artery stenoses.
  
  
  METHODS
  Coronary angiography and contrast material-enhanced, electrocardiographically triggered electron-beam CT of the heart were performed in 23 patients. With axial CT images and axial maximum intensity projection reconstructions, the coronary arteries were assessed by two observers blinded to the results of angiography.
  
  
  RESULTS
  Cardiac motion artifact (unsharpness) precluded evaluation of the right coronary artery (RCA) in six subjects and the left circumflex coronary artery (LCX) in one patient. With the vessels degraded by motion artifact eliminated from analysis, overall sensitivity of electron-beam CT for hemodynamically significant stenoses was 88%, and specificity was 79%. In the left anterior descending coronary artery (LAD), sensitivity was 93% and specificity was 63%; in the LCX, sensitivity was 100% and specificity was 67%; and in the RCA, sensitivity was 67% and specificity was 77%. The presence of coronary artery calcification did not have an effect on sensitivity for stenoses, but it did decrease specificity.
  
  
  CONCLUSIONS
  Electron-beam CT angiography can depict hemodynamically significant stenoses in the LAD and LCX with a sensitivity of more than 90%. The presence of coronary artery calcification resulted in decreased specificity but no appreciable change in sensitivity.
authors.affiliation: Department of Radiology, University of California, San Francisco 94143, USA.
authors.forename: G P
authors.initials: GP
authors.lastname: Reddy
authors.forename: D M
authors.initials: DM
authors.lastname: Chernoff
authors.forename: J R
authors.initials: JR
authors.lastname: Adams
authors.forename: C B
authors.initials: CB
authors.lastname: Higgins
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016477:Artifacts; D002114:Calcinosis / Q000000981:diagnostic imaging; D003287:Contrast Media; D017023:Coronary Angiography / Q000379:methods*; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D003331:Coronary Vessels / Q000473:pathology; D004562:Electrocardiography; D005069:Evaluation Studies as Topic; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D007472:Iohexol; D008297:Male; D008875:Middle Aged; D011856:Radiographic Image Enhancement / Q000379:methods*; D012680:Sensitivity and Specificity; D016037:Single-Blind Method; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; D007472:Iohexol