title: [Hydrocortisone Acetate Reference Standard (Control 961) of National Institute of Health Sciences].
abstract: The raw material of hydrocortisone acetate was tested for the preparation of the "Hydrocortisone Acetate Reference Standard (Control 961)". Analytical data obtained were as follows: IR spectrum, specific absorption wave numbers at 3428, 1748, 1723, 1631, and 1375 cm-1; specific absorbance, E1cm1% (242 nm) = 406; thin-layer chromatography, no impurities were detected until 0.05 microgram; high-performance liquid chromatography (HPLC), 2-3 impurities were detected and the amount of the total impurities was estimated to be about 0.2%; assay by HPLC, 100.7%. Based on the above results, the raw material was authorized as the Japanese Pharmacopoeia Reference Standard (Control 961).
authors.forename: Y
authors.initials: Y
authors.lastname: Tagashira
authors.forename: A
authors.initials: A
authors.lastname: Kitajima
authors.forename: K
authors.initials: K
authors.lastname: Maekawa
authors.forename: K
authors.initials: K
authors.lastname: Yoshii
authors.forename: T
authors.initials: T
authors.lastname: Tanimoto
authors.forename: S
authors.initials: S
authors.lastname: Okada
mesh_terms: D006854:Hydrocortisone / Q000031:analogs & derivatives* / Q000592:standards; D007564:Japan; D012015:Reference Standards
chemical_list: C021650:hydrocortisone acetate; D006854:Hydrocortisone