Cytogenetics of a malignant ovarian germ-cell tumor.
Cytogenetic investigation of a malignant ovarian tumor diagnosed as a mixed germ-cell tumor, composed of extensive choriocarcinoma and foci of yolk-sac tumor, revealed a highly abnormal chromosomal pattern. We found a chromosome number in the hypertriploid/hypotetraploid range, and several clonal structural abnormalities, including 2 copies of an isochromosome 12p. We showed that the chromosomal pattern of this ovarian tumor is very similar to that of testicular germ-cell tumors. This finding, together with reported cytogenetic data of malignant ovarian germ-cell tumors, supports the hypothesis that ovarian and testicular germ-cell tumors are strongly related entities that may have a similar origin and pathogenetic pathway.
van Echten
J
J
Department of Medical Genetics, University of Groningen, The Netherlands. J.van.Echten-Arends@Med.Rug.nl
van Doorn
L C
LC
van der Linden
H C
HC
van der Veen
A Y
AY
Burger
C W
CW
de Jong
B
B
D000328:Adult; D000782:Aneuploidy; D002869:Chromosome Aberrations; D002881:Chromosomes, Human, Pair 12; D005260:Female; D018237:Germinoma / Q000235:genetics*; D006801:Humans; D018404:Isochromosomes; D007621:Karyotyping; D010051:Ovarian Neoplasms / Q000235:genetics*