Qualitative changes of anticonvulsant action of felbamate during development in rats.
The anticonvulsant action of felbamate (25, 50, 100 and 150 mg/kg i.p.) was tested against motor seizures induced by pentylenetetrazol in five age-groups of rats (7, 12, 18, 25 and 90 days old). In adult rats, felbamate suppressed generalized tonic-clonic seizures leaving intact minimal clonic seizures. In all groups of rat pups felbamate exhibited a specific action against the tonic phase of generalized tonic-clonic seizures. In addition, the highest dose of felbamate was found to suppress minimal seizures in 18-day-old rats. The changes of felbamate action during ontogeny might be due to multiple mechanisms of anticonvulsant action with an uneven developmental profile.
Haugvicová
R
R
Institute of Physiology of the Academy of Sciences of the Czech Republic, Prague.
Kubová
H
H
Mares
P
P
D000375:Aging / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development / Q000502:physiology*; D000927:Anticonvulsants / Q000627:therapeutic use*; D003292:Convulsants; D004305:Dose-Response Relationship, Drug; D000078328:Felbamate; D008297:Male; D010433:Pentylenetetrazole; D048448:Phenylcarbamates; D011409:Propylene Glycols / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*
D000927:Anticonvulsants; D003292:Convulsants; D048448:Phenylcarbamates; D011409:Propylene Glycols; D010433:Pentylenetetrazole; D000078328:Felbamate