title: Apolipoprotein E alleles in women with severe pre-eclampsia.
abstract: This study investigated the frequency of apolipoprotein E (apoE) alleles among women with severe pre-eclampsia. The presence of the three most common apoE alleles (epsilon 2, epsilon 3, epsilon 4) was determined by polymerase chain reaction-restriction fragment length polymorphism in three groups of white women: non-pregnant healthy (n = 101), pregnant healthy (n = 52), and pregnant with a diagnosis of severe pre-eclampsia (n = 54). The frequency of apo epsilon 2 was highest among women with severe pre-eclampsia (16.6%) followed by non-pregnant women (12.9%), and those experiencing a healthy pregnancy (10.6%). The higher frequency of the apo epsilon 2 allele detected among women with severe pre-eclampsia suggests that apoE may play a role in the development of pre-eclampsia.
authors.affiliation: First Department of Obstetrics and Gynecology, Semmelweis University Medical School, Budapest, Hungary. NABAL@NOI1.SOTE.HU
authors.forename: B
authors.initials: B
authors.lastname: Nagy
authors.forename: J
authors.initials: J
authors.lastname: Rigó
authors.forename: L
authors.initials: L
authors.lastname: Fintor
authors.forename: I
authors.initials: I
authors.lastname: Karádi
authors.forename: T
authors.initials: T
authors.lastname: Tóth
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy
chemical_list: D001057:Apolipoproteins E