Effect of intra-arachnoid space perfusion on thromboxane A and prostacycline in experimental spinal cord injury.
In order to understand the relation between TXA2-PGI2 and secondary trauma and the effect of intra-arachnoid perfusion of dexamethasone and verapamil on alteration of TXA2-PGI2 following spinal cord injury, TXB2 and 6-keto-PGF alpha concentration and pathological changes in injured site 1, 2, 4, and 6 h after injury were studied using a rabbit spinal cord injury model by Allen's weight drop method.
Tu
Y
Y
Department of Orthopedics, Xiehe Hospital, Tongji Medical University, Wuhan.
Du
J
J
Xia
Z
Z
Wang
L
L
D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology*; D007278:Injections, Spinal; D008297:Male; D011817:Rabbits; D013119:Spinal Cord Injuries / Q000378:metabolism*; D013929:Thromboxane B2 / Q000378:metabolism*; D014700:Verapamil / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D002121:Calcium Channel Blockers; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D003907:Dexamethasone; D014700:Verapamil