title: Electronic monitoring of adherence to treatment in the preventive chemotherapy of tuberculosis.
abstract: METHODS
  Non-adherence to treatment is a frequent problem in the preventive chemoprophylaxis of tuberculosis.
  
  
  OBJECTIVE
  To evaluate the usefulness of the Medication Event Monitoring System (MEMS) for following and improving patient adherence to 6-month treatment with isoniazid.
  
  
  METHODS
  Three methods of monitoring compliance, MEMS, pill count and a urine test for isoniazid, were compared prospectively in 30 patients. The efficacy of a combined intervention by the physician and the pharmacist was evaluated in non-compliant patients.
  
  
  RESULTS
  According to the MEMS data, overall adherence to isoniazid therapy was 91.5%, and 86% of the patients were considered compliant throughout the period of observation. The pill count and the urine test tended to overestimate the overall compliance when compared to the MEMS. The combined intervention of the physician and pharmacist allowed drug adherence to be enhanced in non-compliant patients, but the effect was only transient if this was not repeated every month.
  
  
  CONCLUSIONS
  Our results suggest that the MEMS system is a useful approach for monitoring and improving compliance with preventive chemotherapy for tuberculosis.
authors.affiliation: Policlinique Médicale Universitaire, Lausanne, Switzerland.
authors.forename: C L
authors.initials: CL
authors.lastname: Fallab-Stubi
authors.forename: J P
authors.initials: JP
authors.lastname: Zellweger
authors.forename: A
authors.initials: A
authors.lastname: Sauty
authors.forename: C
authors.initials: C
authors.lastname: Uldry
authors.forename: D
authors.initials: D
authors.lastname: Iorillo
authors.forename: M
authors.initials: M
authors.lastname: Burnier
mesh_terms: D000293:Adolescent; D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use*; D004349:Drug Packaging; D004581:Electronics; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D014376:Tuberculosis / Q000517:prevention & control*
chemical_list: D000995:Antitubercular Agents; D007538:Isoniazid