title: Effect of a booster-dose of rabies vaccine on the duration of virus neutralizing antibody titers in bovines.
abstract: Humoral immune response using inactivated rabies vaccine was studied in 35 nelore cross-bred bovines of western region of São Paulo state. Ninety days after vaccination, 13 (92.8%) animals presented titers > or = 0.5 IU/ml, through mouse neutralization test. After 180 days, 9 (64.3%) sera showed titers > or = 0.5 IU/ml, after 270 days, only one (7.1%) showed a titer of 0.51 IU/ml, and after 360 days, all animals showed titers < 0.5 IU/ml. Group of animals receiving booster dose 30 days after vaccination presented, two months after, all with titers > 0.5 IU/ml. At 180 days, 17 (80.9%) sera presented titers > 0.5 IU/ml; at 270 days, 15 (71.4%), with titers > or = 0.5 IU/ml and at 360 days, 4 (19.0%), with titers > or = 0.5 IU/ml. Booster-dose ensured high levels of neutralizing antibodies for at least three months, and 240 days after revaccination, 71.4% of animals were found with titers > or = 0.5 IU/ml.
authors.affiliation: Instituto Biológico, Faculdade de Ciências Agrárias, Universidade do Oeste Paulista, SP, Brasil.
authors.forename: A
authors.initials: A
authors.lastname: Albas
authors.forename: P E
authors.initials: PE
authors.lastname: Pardo
authors.forename: A A
authors.initials: AA
authors.lastname: Gomes
authors.forename: F
authors.initials: F
authors.lastname: Bernardi
authors.forename: F H
authors.initials: FH
authors.lastname: Ito
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D001938:Brazil; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000517:prevention & control*; D007117:Immunization, Secondary / Q000706:statistics & numerical data / Q000662:veterinary*; D009500:Neutralization Tests / Q000706:statistics & numerical data / Q000662:veterinary; D011818:Rabies / Q000276:immunology / Q000517:prevention & control* / Q000662:veterinary*; D011819:Rabies Vaccines / Q000008:administration & dosage / Q000276:immunology*; D011820:Rabies virus / Q000276:immunology*; D013997:Time Factors
chemical_list: D000914:Antibodies, Viral; D011819:Rabies Vaccines