title: [New hydroxylapatite cement for craniofacial surgery].
abstract: A new stoechiometric mixture of 27% dicalcium-phosphate (DCPA) and 73% tetra-calcium-phosphate (TTCP) can be prepared with water intraoperatively to a paste that subsequently sets to a structurally stabile implant composed of hydroxyapatite (HA). Primary setting time is about 20 min; pH during setting ranges from 6.5 to 8.5. There is no relevant curing heat or expansion or contraction. Compressive strength is about 50 MPa, tensile strength about 8 MPa. Over a period of about 4 h in physiological milieu, the cement converts to hydroxyapatite. This product is no longer redissolvable in normal body fluid. This cement can be used for non-load-bearing applications especially in craniofacial bone surgery. Cranial defects due to tumour or trauma as well as deficits in the facial skeleton may be reconstructed using this new biomaterial. In nine of ten patients we used the hydroxyapatite cement successfully for reconstructions in the craniofacial area. Fluid control of the operation field and implant site is extremely important and sometimes difficult to achieve. Further applications could be all non-load-bearing augmentations such as filling of blocked paranasal sinuses, of dentoalveolar cysts and defects following dental apectomy or fixation of implanted hearing-aid electrodes. The perspectives for the hydroxyapatite cement include its application as a carrier for osteogenic protein preparations, especially because of its isothermic reaction and intrinsic osteoconductive characteristics.
authors.affiliation: Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie, Universität Würzburg.
authors.forename: H
authors.initials: H
authors.lastname: Pistner
authors.forename: J
authors.initials: J
authors.lastname: Reuther
authors.forename: E
authors.initials: E
authors.lastname: Reinhart
authors.forename: N
authors.initials: N
authors.lastname: Kübler
authors.forename: B
authors.initials: B
authors.lastname: Priessnitz
mesh_terms: D001843:Bone Cements / Q000737:chemistry; D016025:Bone Transplantation; D019465:Craniofacial Abnormalities / Q000000981:diagnostic imaging / Q000601:surgery; D003399:Craniotomy / Q000379:methods*; D017886:Durapatite / Q000737:chemistry; D005500:Follow-Up Studies; D006801:Humans; D011183:Postoperative Complications / Q000000981:diagnostic imaging; D011859:Radiography; D012887:Skull Fractures / Q000000981:diagnostic imaging / Q000601:surgery; D012888:Skull Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery; D013329:Structure-Activity Relationship; D013718:Tensile Strength; D014184:Transplantation, Homologous
chemical_list: D001843:Bone Cements; D017886:Durapatite
vernacular_title: Neuer Hydroxylapatitzement für die kraniofaciale Chirurgie.