Verapamil for the treatment of acute mania: a double-blind, placebo-controlled trial.
OBJECTIVE
This study investigated the efficacy of verapamil in acute mania.


METHODS
The study was a 3-week double-blind, random-assignment, parallel-group, placebo-controlled inpatient trial of verapamil for patients with acute mania. Of the 32 study patients, 15 were given placebo and 17 were given verapamil.


RESULTS
Mean absolute change scores on the Mania Rating Scale at endpoint, with baseline scores as the covariates, did not differ between the verapamil and placebo groups. There were no significant differences between the two groups in age, sex, and presence of psychosis.


CONCLUSIONS
The investigators found no benefit of verapamil over placebo in treating acute mania.
Janicak
P G
PG
Psychiatric Institute, University of Illinois at Chicago 60612, USA.
Sharma
R P
RP
Pandey
G
G
Davis
J M
JM
D000208:Acute Disease; D000328:Adult; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000523:psychology; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D010919:Placebos; D011569:Psychiatric Status Rating Scales; D016896:Treatment Outcome; D014700:Verapamil / Q000008:administration & dosage / Q000627:therapeutic use*
D002121:Calcium Channel Blockers; D010919:Placebos; D014700:Verapamil