[Relation between chemical structure and antimycobacterial activity against atypical strains. XIII. Thiosalicylanilides].
On the basis of a preliminary study of antimycobacterial activity of thiobenzanilides a series of eight thiosalicylanilides have been prepared. Synthetized compounds have been examined in vitro against Mycobacterium tuberculosis, Mycobacterium kansasii, Mycobacterium avium and Mycobacterium fortuitum. All compounds have been found very active. The values of minimal inhibitory concentrations are summarized in Table 1. 3',4'-Salicylanilide was selected for the following research. The compound have been found inactive in vivo (on experimental murine tuberculosis).
Waisser
K
K
Katedra anorganické a organické chemie Farmaceutické fakulty Univerzity Karlovy, Hradec.
Kubicová
L
L
Gregor
J
J
Budová
J
J
Andrlová
A
A
Drsata
J
J
Odlerová
Z
Z
D000818:Animals; D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D008826:Microbial Sensitivity Tests; D009170:Nontuberculous Mycobacteria / Q000254:growth & development*; D051381:Rats; D017208:Rats, Wistar; D012458:Salicylanilides / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D013329:Structure-Activity Relationship
D000995:Antitubercular Agents; D012458:Salicylanilides
Vztahy mezi chemickou strukturou látek a jejich antimykobakteriální aktivitou vůci atypickým kmenům XIII. Thiosalicylanilidy.