About 8-hour variation of circulating human endothelin-1.
Plasma endothelin-1 (ET-1) and cortisol were measured around the clock at hourly intervals on 7 clinically healthy, diurnally active, nocturnally resting subjects 22-27 years of age. The circadian rhythm in cortisol is demonstrated for each subject (p < or = 0.020) as well as on a group basis (p = 0.002), peaking in the morning. By contrast, the circadian variation of ET-1 is statistically significant in only one of the subjects, and it is not detected for the group as a whole (p > 0.20). Instead, ET-1 is characterized by an about 8-h component (p < 0.001) that is not found for cortisol.
Herold
M
M
Universitäts-Klinik für Innere Medizin, Innsbruck, Austria.
Cornélissen
G
G
Loeckinger
A
A
Koeberle
D
D
Koenig
P
P
Halberg
F
F
D000328:Adult; D002940:Circadian Rhythm / Q000502:physiology*; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D012016:Reference Values
D019332:Endothelin-1; D006854:Hydrocortisone