title: [No variation in chloroquine resistance (Plasmodium falciparum) from 1986 to 1996 in semi-immune children in Brazzaville (Congo)].
abstract: A simplified Plasmodium falciparum in vivo test was carried out in Brazzaville (Congo) in April 1996. Chloroquine was prescribed at 25 mg/kg for 3 days in asymptomatic Brazzavillian school children who presented parasitemia > 800 P. falciparum trophozoïtes and lived in a highly endemic district. A massive decrease of parasitemia was observed on day 2. The percentage of resistance (presence of P. falciparum trophozoïte on day 7 in a thick blood film) was 43.5, 28 and 21 respectively (IC: 95%: 29-57, 15-41 & 10-34) at the threshold of 6, 50 and 100 parasites/microliter. In positive children on day 7 the reduction of parasitemia was > 95% and no case of R3 resistance was detected. A comparison with previous studies carried out in 1985, 1986, 1990 and 1993 in the same school using the same methodology proves the long-lasting stabilization of chloroquino-resistance for this semi-immune indigenous population.
authors.affiliation: UFR de médecine et CHU des Antilles-Guyane, Cayenne.
authors.forename: B
authors.initials: B
authors.lastname: Carme
authors.forename: M
authors.initials: M
authors.lastname: Ndounga
authors.forename: A M
authors.initials: AM
authors.lastname: Kissila
authors.forename: G
authors.initials: G
authors.lastname: Samba
authors.forename: N
authors.initials: N
authors.lastname: Baya Tsika
mesh_terms: D002648:Child; D002738:Chloroquine / Q000627:therapeutic use*; D003223:Congo; D004351:Drug Resistance; D006801:Humans; D007113:Immunity, Innate; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000276:immunology
chemical_list: D002738:Chloroquine
vernacular_title: Niveau de chloroquinorésistance inchangée (Plasmodium falciparum) de 1986 à 1996 chez les enfants semi-immuns à Brazzaville (Congo).