Lead poisoning, haem synthesis and 5-aminolaevulinic acid dehydratase.
In mammals and yeast, 5-aminolaevulinic acid dehydratase is a zinc-dependent enzyme that catalyses the synthesis of porphobilinogen-the pyrrole building block that is incorporated into all modified tetrapyrroles, including haem, chlorophyll and vitamin B12. The X-ray structure of this enzyme reveals how substitution of the catalytically important zinc ion by lead inactivates the enzyme and causes a form of pseudo-porphyria.
Warren
M J
MJ
Dept of Molecular Genetics, Institute of Ophthalmology, London, UK. warren@ucl.ac.uk
Cooper
J B
JB
Wood
S P
SP
Shoolingin-Jordan
P M
PM
D000818:Animals; D006418:Heme / Q000096:biosynthesis*; D006801:Humans; D007854:Lead / Q000378:metabolism; D007855:Lead Poisoning / Q000378:metabolism*; D008956:Models, Chemical; D008958:Models, Molecular; D000623:Porphobilinogen Synthase / Q000737:chemistry / Q000378:metabolism*; D011487:Protein Conformation
D007854:Lead; D006418:Heme; D000623:Porphobilinogen Synthase