Alpha tocopherol in CSF of subjects taking high-dose vitamin E in the DATATOP study. Parkinson Study Group.
Alpha-Tocopherol concentrations were determined in the CSF of patients with early untreated Parkinson's disease receiving 2,000 IU vitamin E orally per day. After treatment the concentrations increased significantly (p < 0.001) by 76+/-10 (SE)%. The net increases in CSF alpha-tocopherol concentrations after treatment showed a significant positive correlation with the number of days of vitamin E ingestion (p < 0.001). Thus, high-dose vitamin E treatment results in elevating CSF vitamin E levels and possibly brain vitamin E levels.
Vatassery
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GRECC, VA Medical Center, Department of Psychiatry, University of Minnesota, Minneapolis 55417, USA.
Fahn
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Kuskowski
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D000975:Antioxidants / Q000627:therapeutic use; D000978:Antiparkinson Agents / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006801:Humans; D010300:Parkinson Disease / Q000188:drug therapy*; D012642:Selegiline / Q000627:therapeutic use; D014810:Vitamin E / Q000008:administration & dosage* / Q000134:cerebrospinal fluid* / Q000627:therapeutic use
D000975:Antioxidants; D000978:Antiparkinson Agents; D014810:Vitamin E; D012642:Selegiline