[Study of the expression of the epidermal growth factor-receptor in the laryngeal squamous cell carcinoma and the correlation with clinical pathology characteristics].
OBJECTIVE
The expression of the epidermal growth factor-receptor (EGF-R) in the laryngeal squamous cell carcinoma and the correlation with clinical characteristics of the tumor, difference of tissues.


METHODS
Immunohistochemical detection.


RESULTS
The EGF-R expression was evaluated in 36 laryngeal squamous cell carcinoma and 25 normal laryngeal tissues specimens. The EGF-R expression showed only in one specimen of normal laryngeal tissues, whereas twenty-four of thirty-six carcinomas showed positive staining reaction with the anti EGF-R antibodies. The EGF-R expression did not correlate with age, whereas it was higher in poorly differentiated tumors than in moderately and well differentiated tumors (P < 0.05) and it was higher in T3, 4 of TNM classification than in T1, 2 (P < 0.05). Four patients being the recurrence cancers after the operation had an enhanced expression of EGF-R. Six of seven patients with the metastatic cervicallymph-node involvement showed an enhanced expression of EGF-R.


CONCLUSIONS
The uncontrolled cell growth and proliferation of the laryngeal squamous cell carcinomas may be related to the abnormal EGF-R expression. The enhanced expression of EGF-R can be identified as a poorly prognostic parameter.
Fu
Z
Z
Department of Otolaryngology, Union Hospital, Tongji Medical University, Wuhan.
Wang
J
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D066246:ErbB Receptors / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local
D066246:ErbB Receptors