Cyclosporine distribution into the conjunctiva, cornea, lacrimal gland, and systemic blood following topical dosing of cyclosporine to rabbit, dog, and human eyes.
Acheampong
A
A
Allergan, Irvine, California, USA.
Shackleton
M
M
Lam
S
S
Rudewicz
P
P
Tang-Liu
D
D
D000287:Administration, Topical; D000818:Animals; D003228:Conjunctiva / Q000378:metabolism*; D003315:Cornea / Q000378:metabolism*; D016572:Cyclosporine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007638:Keratoconjunctivitis Sicca / Q000188:drug therapy / Q000378:metabolism*; D007765:Lacrimal Apparatus / Q000378:metabolism*; D008657:Metabolic Clearance Rate; D011817:Rabbits; D014018:Tissue Distribution
D016572:Cyclosporine