title: Influence of the sequence of administration of beta-glucans and a Vibrio damsela vaccine on the immune response of turbot (Scophthalmus maximus L.).
abstract: Yeast (Saccharomyces cerevisae) beta-1,3 glucans were used as adjuvant in a Vibrio damsela vaccine for turbot (Scophthalmus maximus L.). Turbot were injected with the adjuvant prior, at the same time and after the vaccine. Several immune parameters (index and rate of phagocytosis, passive haemolytic plaque numbers, and agglutinating antibody titers) were determined at different times postinoculation. The highest activity of all the immune parameters was obtained when glucans were injected after the bacterin. It is concluded that the sequence of glucan administration is critical when used as a vaccine adjuvant.
authors.affiliation: Instituto de Investigaciones Marinas, Consejo Superior de Investigaciones Científicas (CSIC), Vigo, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Figueras
authors.forename: M M
authors.initials: MM
authors.lastname: Santarém
authors.forename: B
authors.initials: B
authors.lastname: Novoa
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage*; D005412:Flatfishes / Q000276:immunology*; D005936:Glucans / Q000008:administration & dosage* / Q000276:immunology; D006388:Hemagglutinins / Q000096:biosynthesis; D006462:Hemolytic Plaque Technique; D007115:Immunization Schedule; D019081:O Antigens / Q000008:administration & dosage; D010587:Phagocytosis; D012441:Saccharomyces cerevisiae / Q000276:immunology; D014733:Vibrio / Q000276:immunology*; D047071:beta-Glucans
chemical_list: D000276:Adjuvants, Immunologic; D001428:Bacterial Vaccines; D005936:Glucans; D006388:Hemagglutinins; D019081:O Antigens; D047071:beta-Glucans; C033363:beta-1,3-glucan