Beta-adrenoceptor-stimulated renin release is blunted in old rats.
Plasma renin activity (PRA) was similar in young versus old male Sprague Dawley rats under unstressed conditions (1.3 +/- 0.2 versus 1.8 +/- 0.3 ng angiotensin I/ml per min). Airjet stress increases PRA in young but not old rats (13.9 +/- 3.8 versus 2.9 +/- 0.8 ng angiotensin I/ml per min), respectively. This response is ablated in young rats by beta-adrenoceptor blockade, suggesting that the increased PRA is mediated by beta-adrenoceptors, and this response was blunted in old rats.
Baylis
C
C
Department of Physiology, West Virginia University, Morgantown 26506-9229, USA.
Engels
K
K
Beierwaltes
W H
WH
D000375:Aging / Q000097:blood*; D000818:Animals; D004195:Disease Models, Animal; D008297:Male; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000378:metabolism*; D012016:Reference Values; D012083:Renin / Q000097:blood*; D012084:Renin-Angiotensin System / Q000187:drug effects / Q000502:physiology; D013312:Stress, Physiological / Q000097:blood*
D011943:Receptors, Adrenergic, beta; D011433:Propranolol; D012083:Renin