title: Characterization of the earliest known Staphylococcus aureus plasmid encoding a multidrug efflux system.
abstract: The staphylococcal qacB-encoding multidrug resistance plasmid pSK156, isolated from a clinical strain dating from 1951, was characterized. Comparison of the regions flanking qacB with other qacA- and qacB-encoding plasmids provided insights into the evolution and dissemination of these multidrug efflux genes and led to the detection of the earliest known copy of the insertion sequence IS257.
authors.affiliation: School of Biological Sciences, University of Sydney, New South Wales, Australia.
authors.forename: I T
authors.initials: IT
authors.lastname: Paulsen
authors.forename: M H
authors.initials: MH
authors.lastname: Brown
authors.forename: R A
authors.initials: RA
authors.lastname: Skurray
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics*; D002874:Chromosome Mapping; D002876:Chromosomes, Bacterial; D004251:DNA Transposable Elements; D018432:Drug Resistance, Multiple / Q000235:genetics*; D019143:Evolution, Molecular; D026901:Membrane Transport Proteins; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D011815:R Factors; D015183:Restriction Mapping; D017384:Sequence Deletion; D013211:Staphylococcus aureus / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; D002352:Carrier Proteins; D004251:DNA Transposable Elements; D026901:Membrane Transport Proteins; C099272:QacB protein, Staphylococcus aureus