Removal of morphine with the new high-efficiency and high-flux membranes during haemofiltration and haemodialfiltration.
We present three critically ill patients with severe renal failure who required haemofiltration or haemodiafiltration, with high-efficiency or high-flux membranes, while receiving an intravenous infusion of morphine. We show that despite the very high ultrafiltrability/diffusability of free morphine, only 1-3% of the total amount of infused morphine is removed in 24 h. This is in marked contrast to haemodialysis where, owing to much higher dialysate flow rate, a significant quantity of free morphine is removed.
Jamal
J A
JA
Division of Nephrology, St. Louis University Health Sciences Center, Missouri, USA.
Joh
J
J
Bastani
B
B
D058186:Acute Kidney Injury / Q000097:blood / Q000188:drug therapy / Q000628:therapy; D000328:Adult; D016638:Critical Illness; D005260:Female; D017583:Hemodiafiltration / Q000295:instrumentation / Q000379:methods*; D006440:Hemofiltration / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage / Q000097:blood / Q000302:isolation & purification*
D009020:Morphine