Pharmacokinetics and efficacy of long-term low-level administration of triclabendazole in urea molasses blocks against induced bovine and bubaline fasciolosis.
The pharmacokinetics and flukicidal efficacy of triclabendazole delivered in low doses on a daily basis through urea molasses blocks were studied in cattle and buffaloes experimentally infected with Fasciola gigantica. The observations were compared with single therapeutic doses at 12.0 and 24.0 mg/kg body weight in cattle and buffaloes, respectively, prior to becoming experimentally infected. After receipt of triclabendazole by cattle and buffaloes at 0.83 and 3.0 mg/kg body weight, respectively, on a daily basis, both the animal species exhibited equilibrium between its absorption and disposition of its metabolites in plasma on day 4 and remained almost unchanged thereafter. The continuous subtherapeutic dosing of triclabendazole through urea molasses block at 0.83 mg/kg body weight in cattle and 3.0 mg/kg body weight in buffalo proved to be efficacious against mature liver flukes.
Sanyal
P K
PK
Biotechnology Laboratory, National Dairy Development Board, Anand, Gujarat, India. pksanyal@anand.nddb.ernet.in
Gupta
S C
SC
D000284:Administration, Oral; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D002020:Buffaloes; D002417:Cattle; D002418:Cattle Diseases; D002626:Chemistry, Pharmaceutical; D004334:Drug Administration Schedule; D005209:Fasciola / Q000254:growth & development; D005211:Fascioliasis / Q000517:prevention & control / Q000662:veterinary*; D008195:Lymnaea / Q000469:parasitology; D008297:Male; D008965:Molasses; D012417:Rumen; D000077682:Triclabendazole; D014508:Urea
D000871:Anthelmintics; D001562:Benzimidazoles; D000077682:Triclabendazole; D014508:Urea