Colonic strictures induced by nonsteroidal anti-inflammatory drugs.
Long-term use of nonsteroidal anti-inflammatory drugs has been reported to cause small bowel and colonic ulcerations and strictures. Abdominal pain, change in bowel habits, and anemia are frequently present, mimicking other inflammatory and neoplastic diseases of the gut. We report two cases of drug-induced colonic stricture that illustrate two different spectrums of this disease. The first is a case of ascending colon ulcerated strictures and severe anemia managed conservatively, and the second is a chronic variant with obstructive-type symptoms and a tight nonulcerated colonic stricture that necessitated right hemicolectomy.
Ribeiro
A
A
Department of Pathology, Mayo Clinic Jacksonville, Fla 32224, USA.
Wolfsen
H C
HC
Wolfe
J T
JT
Loeb
D S
DS
D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D002908:Chronic Disease; D003108:Colonic Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D003113:Colonoscopy; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology; D007415:Intestinal Obstruction / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D008134:Long-Term Care; D008875:Middle Aged; D014456:Ulcer / Q000139:chemically induced / Q000175:diagnosis / Q000473:pathology
D000894:Anti-Inflammatory Agents, Non-Steroidal