title: Effect of continuous positive airway pressure on forced expiratory flows in infants with tracheomalacia.
abstract: Continuous positive airway pressure (CPAP) is used to minimize airway collapse in infants with tracheomalacia. Forced expiratory flows (FEFs) at functional residual capacity (FRC) increase with increasing CPAP in infants with tracheomalacia, and it has been suggested that CPAP prevents airway collapse by "stenting" the airway open. Since FEF is greater at higher than at lower lung volumes, we evaluated whether the increase in flow measured at FRC (V FRC) with CPAP could be explained by the increase in FRC with CPAP. We measured full FEF-volume curves at CPAP levels of 0, 4, and 8 cm H2O in six infants with tracheomalacia and five healthy control infants. In both groups of infants, FVC did not change with CPAP; however, inspiratory capacity (IC) decreased and thus FRC increased with increasing CPAP. FEFs at FRC increased with increasing levels of CPAP; however, the FEFs at 50% and 75% of expired volume were not different for the three levels of CPAP for both groups of infants. Our finding that FEFs measured at the same lung volumes did not differ for the different levels of CPAP indicates that CPAP affects forced flows primarily by increasing lung volume.
authors.affiliation: Department of Pediatrics, Indiana University Medical Center, James Whitcomb Riley Hospital for Children, Indianapolis, Indiana, USA.
authors.forename: S
authors.initials: S
authors.lastname: Davis
authors.forename: M
authors.initials: M
authors.lastname: Jones
authors.forename: J
authors.initials: J
authors.lastname: Kisling
authors.forename: C
authors.initials: C
authors.lastname: Angelicchio
authors.forename: R S
authors.initials: RS
authors.lastname: Tepper
mesh_terms: D005540:Forced Expiratory Flow Rates; D006801:Humans; D007223:Infant; D008168:Lung / Q000503:physiopathology*; D011175:Positive-Pressure Respiration; D014133:Tracheal Diseases / Q000503:physiopathology* / Q000628:therapy*; D014797:Vital Capacity