Methylprednisolone in bilayer liposomes prolongs cardiac and renal allograft survival, inhibits macrophage activation, and selectively modifies antigen presentation and T-helper cell function in rat recipients.
Binder
J
J
Department of Urology and Pediatric Urology, Johann Wolfgang Goethe University Medical Center, Frankfurt am Main, Germany.
Braeutigam
R
R
Oertl
A
A
Kramer
W
W
Jonas
D
D
Hancock
W W
WW
Kupiec-Weglinski
J W
JW
D000818:Animals; D000938:Antigen-Presenting Cells / Q000187:drug effects / Q000276:immunology; D004337:Drug Carriers; D006085:Graft Survival / Q000187:drug effects* / Q000276:immunology; D016027:Heart Transplantation / Q000276:immunology* / Q000473:pathology; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000276:immunology* / Q000473:pathology; D008051:Lipid Bilayers; D008262:Macrophage Activation / Q000187:drug effects; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000627:therapeutic use; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects / Q000276:immunology; D014184:Transplantation, Homologous
D004337:Drug Carriers; D007166:Immunosuppressive Agents; D008051:Lipid Bilayers; D008775:Methylprednisolone