title: Ribozymes: the hammerhead swings into action.
abstract: A new crystal structure of a modified hammerhead ribozyme reveals an intermediate conformation that may explain discrepancies between previous structures and the required orientation of the labile bond in the ribozyme's active site.
authors.affiliation: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520-8114, USA. doudna@csb.yale.edu
authors.forename: J A
authors.initials: JA
authors.lastname: Doudna
mesh_terms: D001483:Base Sequence; D001665:Binding Sites; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D016337:RNA, Catalytic / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D016337:RNA, Catalytic