title: Enzyme replacement therapy decreases hypergammaglobulinemia in Gaucher's disease.
abstract: We report the effects of enzyme replacement therapy in a patient with Gaucher's disease associated with a monoclonal gammopathy. Alglucerase induces a linear decline in immunoglobulin and beta 2-microglobulin levels. This observation suggests that this treatment decreases the chronic antigenic stimulation commonly found in Gaucher's disease.
authors.forename: J
authors.initials: J
authors.lastname: Deibener
authors.forename: P
authors.initials: P
authors.lastname: Kaminsky
authors.forename: C
authors.initials: C
authors.lastname: Jacob
authors.forename: B
authors.initials: B
authors.lastname: Dousset
authors.forename: M
authors.initials: M
authors.lastname: Klein
authors.forename: M
authors.initials: M
authors.lastname: Duc
mesh_terms: D000328:Adult; D005776:Gaucher Disease / Q000150:complications / Q000188:drug therapy*; D005962:Glucosylceramidase / Q000627:therapeutic use*; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications / Q000188:drug therapy*; D008297:Male
chemical_list: C070292:alglucerase; D005962:Glucosylceramidase