Inhibition of the development of spontaneous autoimmune thyroiditis in the obese strain (OS) chickens by in vivo treatment with anti-CD4 or anti-CD8 antibodies.
The involvement of CD4+ and CD8+ T cells in pathogenesis of spontaneous autoimmune thyroiditis (SAT) in obese strain (OS) chickens has not been studied in depth until now. We depleted CD4+ or CD8+ T cells in OS chickens by treatment with murine monoclonal anti-CD4 or anti-CD8 antibodies at 3 day intervals beginning at hatching. The birds were killed at 19-25 days of age. Treatment with anti-CD4 antibody completely prevented SAT development, while treatment with anti-CD8 antibody partially inhibited SAT. These results show the critical role of CD4+ T cells in the development of SAT in OS chickens, and indicate that CD8+ T cells are also involved in SAT pathogenesis.
Cihak
J
J
Institute for Animal Physiology, University of Munich, Germany. cihak@t-online.de
Hoffmann-Fezer
G
G
Wasl
M
M
Merkle
H
H
Kaspers
B
B
Vainio
O
O
Plachý
J
J
Hála
K
K
Wick
G
G
Stangassinger
M
M
Lösch
U
U
D000367:Age Factors; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use*; D001323:Autoantibodies / Q000032:analysis; D015704:CD4 Antigens / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D016827:CD8 Antigens / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002645:Chickens / Q000235:genetics* / Q000276:immunology; D004195:Disease Models, Animal; D007124:Immunoenzyme Techniques; D007178:Inbreeding; D051379:Mice; D009765:Obesity / Q000235:genetics / Q000662:veterinary*; D011201:Poultry Diseases / Q000235:genetics / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D013954:Thyroglobulin / Q000276:immunology; D013961:Thyroid Gland / Q000276:immunology / Q000473:pathology; D013967:Thyroiditis, Autoimmune / Q000235:genetics / Q000276:immunology / Q000473:pathology / Q000517:prevention & control / Q000662:veterinary*
D000911:Antibodies, Monoclonal; D001323:Autoantibodies; D015704:CD4 Antigens; D016827:CD8 Antigens; C006606:anti-thyroglobulin; D013954:Thyroglobulin