Sotalol associated polymorphic ventricular tachycardia and coronary spasm.
Sotalol may induce torsade de pointes through cardiac action potential prolongation, but a proarrhythmic effect secondary to its beta blocking action has not been reported. A 54 year old man presented with symptoms of angina and presyncope, subsequently demonstrated to be associated with coronary spasm. Treatment with sotalol exacerbated his symptoms and resulted in recurrent polymorphic ventricular tachycardia with a pattern indistinguishable from that caused by a class III action. Following sotalol with-drawal polymorphic ventricular tachycardia resolved completely. Polymorphic ventricular tachycardia in patients treated with sotalol may therefore not always be the result of delayed repolarisation, but may be caused by beta adrenoceptor blockade.
Lowe
M D
MD
Department of Cardiology, Papworth Hospital, Cambridge, UK.
Stone
D L
DL
Grace
A A
AA
D000319:Adrenergic beta-Antagonists / Q000009:adverse effects*; D003329:Coronary Vasospasm / Q000139:chemically induced; D015716:Electrocardiography, Ambulatory; D004874:Ergonovine; D006801:Humans; D008297:Male; D008875:Middle Aged; D013015:Sotalol / Q000009:adverse effects*; D017180:Tachycardia, Ventricular / Q000139:chemically induced* / Q000175:diagnosis
D000319:Adrenergic beta-Antagonists; D013015:Sotalol; D004874:Ergonovine