title: Molecular and cellular mechanisms of action of angiotensin II (AT1) receptors in vascular smooth muscle.
abstract: Angiotensin is an important regulator of blood pressure and exerts both pressor actions and influences growth in the cardiovascular system via the AT1 receptor. This review describes a number of signalling mechanisms involved in vasoconstriction and growth in response to AT1 receptor activation in vascular smooth muscle.
authors.affiliation: Clinical Pharmacology, National Heart and Lung Institute, Imperial College of Science, Technology & Medicine, London, UK.
authors.forename: A D
authors.initials: AD
authors.lastname: Hughes
mesh_terms: D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D002478:Cells, Cultured; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007473:Ion Channels / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000378:metabolism*; D011493:Protein Kinase C / Q000378:metabolism; D044140:Receptor, Angiotensin, Type 1; D044139:Receptor, Angiotensin, Type 2; D011945:Receptors, Angiotensin / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D010738:Type C Phospholipases / Q000378:metabolism; D014661:Vasoconstriction
chemical_list: D007473:Ion Channels; D044140:Receptor, Angiotensin, Type 1; D044139:Receptor, Angiotensin, Type 2; D011945:Receptors, Angiotensin; D000804:Angiotensin II; D011493:Protein Kinase C; D010738:Type C Phospholipases