Periodic limb movement disorder in neuroleptic-induced akathisia.
We recorded all-night polysomnograms of four schizophrenic patients with neuroleptic-induced akathisia (NIA) before and during treatment with clonazepam. Also, four non-akathitic schizophrenic patients were recorded all-night polysomnograms as control subjects. Daily treatment with 1.5 to 3 mg clonazepam improved subjective complaints of all the 4 patients with NIA. Three of 4 patients with NIA exhibited periodic limb movements (PLM) on bilateral legs, but none of 4 control subjects showed PLM. Total number of PLM and PLM per hour decreased during clonazepam treatment. Moreover, mean inter-movement intervals of PLM of 3 patients were prolonged on bilateral legs. NIA might change its feature as PLM during night sleep.
Nishimatsu
O
O
Nishimatsu Clinic, Hyogo, Japan.
Horiguchi
J
J
Inami
Y
Y
Sukegawa
T
T
Sasaki
A
A
D000328:Adult; D017109:Akathisia, Drug-Induced / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D000927:Anticonvulsants / Q000008:administration & dosage*; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002998:Clonazepam / Q000008:administration & dosage*; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D012148:Restless Legs Syndrome / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D012559:Schizophrenia / Q000188:drug therapy; D016896:Treatment Outcome
D000927:Anticonvulsants; D014150:Antipsychotic Agents; D002998:Clonazepam