title: Oestrogen-regulated genes in breast cancer: association of pLIV1 with response to endocrine therapy.
abstract: Northern hybridization analyses of the oestrogen-inducible mRNAs pLIV1 and pS2 were compared with oestrogen receptor (ER) immunocytochemistry assessments in 40 untreated primary or early recurrent breast tumours. Significant associations were observed between pLIV1/ER (P < 0.03), pS2/ER (P < 0.001) and pLIV1/pS2 (P < 0.04) status. After disease recurrence, patients were treated with assessable courses of endocrine therapies. Positive pLIV1, pS2 and ER statuses in primary disease were consequently found to be predictive of endocrine responsiveness in the secondary lesions (P < 0.03, P < 0.02, P < 0.005 respectively). However, despite these associations, a number of pLIV1- and/or pS2-positive tumours failed to respond to therapy.
authors.affiliation: Tenovus Cancer Research Centre, University Hospital of Wales, Heath Park, Cardiff, UK.
authors.forename: R A
authors.initials: RA
authors.lastname: McClelland
authors.forename: D L
authors.initials: DL
authors.lastname: Manning
authors.forename: J M
authors.initials: JM
authors.lastname: Gee
authors.forename: P
authors.initials: P
authors.lastname: Willsher
authors.forename: J F
authors.initials: JF
authors.lastname: Robertson
authors.forename: I O
authors.initials: IO
authors.lastname: Ellis
authors.forename: R W
authors.initials: RW
authors.lastname: Blamey
authors.forename: R I
authors.initials: RI
authors.lastname: Nicholson
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics*; D004967:Estrogens / Q000235:genetics* / Q000627:therapeutic use; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D008875:Middle Aged; D009376:Neoplasms, Hormone-Dependent / Q000235:genetics*; D011506:Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism; D011960:Receptors, Estrogen / Q000032:analysis; D000071163:Trefoil Factor-1; D025521:Tumor Suppressor Proteins
chemical_list: D004967:Estrogens; D011506:Proteins; D012333:RNA, Messenger; D011960:Receptors, Estrogen; C051838:TFF1 protein, human; D000071163:Trefoil Factor-1; D025521:Tumor Suppressor Proteins