Cervical spine abnormalities and instability with myelopathy in warfarin-related chondrodysplasia: 17-year follow-up.
A patient with warfarin embryopathy developed progressive cervical spinal myelopathy owing to bony cervical spinal damage. While there are several descriptions of warfarin embryopathy, the long-term complication of cervical spinal instability has not been reported. This cervical instability may, as in our patient, cause severe neurological dysfunction or even sudden death; therefore, it is important that pediatric radiologists should be alert to this condition.
Takano
H
H
Department of Radiology, The University of Iowa Clinics and Hospitals, 200 Hawkins Dr., #3966 JPP, Iowa City, IA 52242-1077, USA.
Smith
W L
WL
Sato
Y
Y
Kao
S C
SC
D000014:Abnormalities, Drug-Induced / Q000000981:diagnostic imaging / Q000209:etiology; D000925:Anticoagulants / Q000009:adverse effects*; D002574:Cervical Vertebrae / Q000002:abnormalities* / Q000000981:diagnostic imaging; D002806:Chondrodysplasia Punctata / Q000139:chemically induced* / Q000000981:diagnostic imaging; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000188:drug therapy; D011655:Pulmonary Embolism / Q000188:drug therapy; D011859:Radiography; D013117:Spinal Cord Compression / Q000000981:diagnostic imaging / Q000209:etiology*; D014859:Warfarin / Q000009:adverse effects*
D000925:Anticoagulants; D014859:Warfarin