title: [Non-palpable lesions of the breast. Retrospective analysis of mammographic and ultrasonographic indications for surgery].
abstract: BACKGROUND
  The differential diagnosis of malignancy in small foci of microcalcifications or in extremely small nodes can be difficult. We carried out a retrospective analysis of integrated mammographic and US results, correlated with histologic data, to assess the limitations of each method and to optimize and benign/malignant ratio.
  
  
  METHODS
  Our series consisted of 485 nonpalpable breast lesions submitted to histologic examination after vegetable charcoal marking. We gave each lesion an 0-5 score according to the degree of diagnostic doubt/suspicion after mammography and US, which results were correlated with histologic data to assess the carcinoma frequency in the various groups identified.
  
  
  RESULTS
  The analysis of mammographic and US images showed that the most frequent mammographic alteration in the lesions submitted to biopsy was an isolated cluster of microcalcifications (40.99%): of these, 36.86% were neoplastic. The nodules submitted to biopsy, which were 29.81% of the total, showed a cancer rate (36.80%) very similar to that of the microcalcifications. The carcinoma rate rose to 37.93% when the microcalcifications were associated with nodes. The highest carcinoma rates, i.e., 52.94% and 66.66%, respectively, were found in parenchymal distortions, either isolated or associated with microcalcifications, which however were only 7.03% and 3.10%, respectively, of the total number of cases.
  
  
  CONCLUSIONS
  Our study showed that: 1) a highly suspicious US result must be seriously considered when a negative mammography has poor intrinsic contrast; 2) a highly suspicious US image with a little suspicious good contrast mammography requires further confirmation before surgery is planned; 3) when the mammographic finding is mid-to-highly suspicious, further investigations are needed even if US is negative. To conclude, even though the histologic examination of nonpalpable breast lesions involves performing a biopsy, we believe this is acceptable when performed on an outpatient basis, under local anesthesia and removing a limited amount of tissue only. The benign/malignant ratio ranges 2 to 1.5: if it is further reduced (below 1.5), there will be the risk of missing some early neoplastic lesions.
authors.affiliation: Servizio di Radiodiagnostica e di Radioterapia, Clinica Mangiagalli, Milano.
authors.forename: L
authors.initials: L
authors.lastname: Recanatini
authors.forename: L
authors.initials: L
authors.lastname: Renoldi
authors.forename: M S
authors.initials: MS
authors.lastname: Sfondrini
authors.forename: B
authors.initials: B
authors.lastname: Di Nubila
authors.forename: L
authors.initials: L
authors.lastname: Marzano
authors.forename: M
authors.initials: M
authors.lastname: Campoleoni
authors.forename: A
authors.initials: A
authors.lastname: Landini
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D003937:Diagnosis, Differential; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D012189:Retrospective Studies; D014463:Ultrasonography
vernacular_title: Lesioni non palpabili della mammella. Analisi retrospettiva delle indicazioni mammografiche ed ecografiche all'intervento chirurgico.