title: Dynamic magnetic resonance imaging in evaluating suspicious breast lesions: correlation with pathologic findings.
abstract: BACKGROUND
  We used dynamic magnetic resonance imaging (MRI) to study breast lesions in 13 women.
  
  
  METHODS
  We observed differences in contrast uptake between benignancy and malignancy in 14 suspicious breast lesions. Three-dimensional (3D) gradient echo sequences were obtained before and after administration of gadolinium-based contrast medium (0.16 mmol/kg). The percentage of signal increase in lesions was measured in a series of five 90-second sequences, and time-enhancement patterns were correlated with pathologic diagnoses.
  
  
  RESULTS
  Seven benign lesions and three breast cancer recurrences showed less than 185% signal increase at 90 seconds after contrast administration. Three new breast cancers and one recently biopsied benign lesion showed more than 185% signal increase at 90 seconds.
  
  
  CONCLUSIONS
  Using this MRI technique, we can discriminate between new breast cancers (more than 185% early signal increase) and breast cancer recurrence and/or benign lesions (less than 185% early signal increase) but cannot distinguish recurrent from benign lesions.
authors.affiliation: Department of Radiology, University of South Alabama, Mobile 36617, USA.
authors.forename: R D
authors.initials: RD
authors.lastname: Snow
authors.forename: D L
authors.initials: DL
authors.lastname: Dyess
authors.forename: M D
authors.initials: MD
authors.lastname: Harpen
authors.forename: C N
authors.initials: CN
authors.lastname: Kreisberg
authors.forename: J A
authors.initials: JA
authors.lastname: Tucker
mesh_terms: D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology; D003287:Contrast Media; D003937:Diagnosis, Differential; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D010865:Pilot Projects; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; C064925:gadodiamide; D019786:Gadolinium DTPA