Endothelial and leukocyte adhesion molecules in inflammation and disease.
Injury associated with ischemia and reperfusion is a significant factor in a number of clinical diseases. We have completed a number of preclinical studies investigating the blockade of leukocyte adhesion molecules in ischemia-reperfusion injury. In our work and in the work of other investigators, monoclonal antibodies directed to CD18, P-selectin and L-selectin were effective in reducing ischemia-reperfusion injury to the rabbit ear and in reducing injury following hemorrhagic shock in both rabbits and nonhuman primates. Ischemia-reperfusion injury was also reduced by synthetic oligosaccharide sLe(x). These studies suggest that adhesion blockade might be effective in the clinical setting.
Winn
R
R
Department of Surgery, University of Washington, USA.
Vedder
N
N
Ramamoorthy
C
C
Sharar
S
S
Harlan
J
J
D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D018821:CD18 Antigens / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007249:Inflammation; D007511:Ischemia; D019041:L-Selectin / Q000276:immunology / Q000502:physiology*; D019007:P-Selectin / Q000276:immunology / Q000502:physiology*; D011817:Rabbits; D015427:Reperfusion Injury / Q000517:prevention & control*; D012771:Shock, Hemorrhagic / Q000517:prevention & control
D000911:Antibodies, Monoclonal; D018821:CD18 Antigens; D019007:P-Selectin; D019041:L-Selectin