Enzyme replacement therapy decreases hypergammaglobulinemia in Gaucher's disease.
We report the effects of enzyme replacement therapy in a patient with Gaucher's disease associated with a monoclonal gammopathy. Alglucerase induces a linear decline in immunoglobulin and beta 2-microglobulin levels. This observation suggests that this treatment decreases the chronic antigenic stimulation commonly found in Gaucher's disease.
Deibener
J
J
Kaminsky
P
P
Jacob
C
C
Dousset
B
B
Klein
M
M
Duc
M
M
D000328:Adult; D005776:Gaucher Disease / Q000150:complications / Q000188:drug therapy*; D005962:Glucosylceramidase / Q000627:therapeutic use*; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications / Q000188:drug therapy*; D008297:Male
C070292:alglucerase; D005962:Glucosylceramidase