Flow-injection spectrophotometric determination of diclofenac sodium in pharmaceuticals and urine samples.
A sensitive and fast flow-injection spectrophotometric method for the determination of diclofenac sodium based on the formation of coloured compound with Ce(IV)-3-methyl-2-benzothiazolinone hydrazone hydrochloride (MBTH) in H2SO4 3 x 10(-2) M medium is proposed. Using the peak height as a quantitative parameter diclofenac was determined at 580 nm over the range 0.20-8.0 micrograms ml-1. The proposed method was successfully applied to the determination of diclofenac in pharmaceuticals and urine samples.
García
M S
MS
Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, Spain.
Albero
M I
MI
Sánchez-Pedreño
C
C
Molina
J
J
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis* / Q000652:urine; D052160:Benzothiazoles; D002563:Cerium; D004008:Diclofenac / Q000032:analysis* / Q000652:urine; D017022:Flow Injection Analysis; D006801:Humans; D006835:Hydrazones; D012996:Solutions / Q000032:analysis; D013050:Spectrometry, Fluorescence / Q000379:methods; D013488:Suppositories / Q000032:analysis; D013607:Tablets / Q000032:analysis; D013844:Thiazoles
D000894:Anti-Inflammatory Agents, Non-Steroidal; D052160:Benzothiazoles; D006835:Hydrazones; D012996:Solutions; D013488:Suppositories; D013607:Tablets; D013844:Thiazoles; D004008:Diclofenac; D002563:Cerium; C002536:3-methyl-2-benzothiazolone hydrazone