title: Prevention of Borrelia burgdorferi transmission in guinea pigs by tick immunity.
abstract: We examined the effect of repeated infestation of guinea pigs with Ixodes scapularis on the capacity of ticks to transmit Borrelia burgdorferi infection. Repeated challenges with nymphs or larvae lead to a reduction in duration of nymphal tick attachment and weight of recovered ticks consistent with the development of tick immunity. Only one of 18 I. scapularis-immune guinea pigs challenged with B. burgdorferi-infected nymphal ticks became infected, whereas 10 of 18 naive guinea pigs similarly challenged became infected. We conclude that tick immunity interferes with borrelial transmission.
authors.affiliation: Department of Internal Medicine, Yale University, New Haven, Connecticut, USA.
authors.forename: S
authors.initials: S
authors.lastname: Nazario
authors.forename: S
authors.initials: S
authors.lastname: Das
authors.forename: A M
authors.initials: AM
authors.lastname: de Silva
authors.forename: K
authors.initials: K
authors.lastname: Deponte
authors.forename: N
authors.initials: N
authors.lastname: Marcantonio
authors.forename: J F
authors.initials: JF
authors.lastname: Anderson
authors.forename: D
authors.initials: D
authors.lastname: Fish
authors.forename: E
authors.initials: E
authors.lastname: Fikrig
authors.forename: F S
authors.initials: FS
authors.lastname: Kantor
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D001096:Arachnid Vectors / Q000276:immunology* / Q000382:microbiology; D015748:Borrelia burgdorferi Group / Q000276:immunology; D005260:Female; D006168:Guinea Pigs; D015151:Immunoblotting; D018884:Ixodes / Q000276:immunology* / Q000382:microbiology; D007814:Larva / Q000276:immunology; D008193:Lyme Disease / Q000517:prevention & control* / Q000635:transmission; D009758:Nymph / Q000276:immunology / Q000382:microbiology; D012867:Skin / Q000469:parasitology; D013984:Tick Infestations / Q000276:immunology*; D013997:Time Factors
chemical_list: D000907:Antibodies, Bacterial