[Glycosylated high density lipoprotein in diabetes related to pregnancy induced hypertension].
OBJECTIVE
To investigate the glycosylation of high density lipoprotein (glc-HDL) and its specific binding to human lung fibroblasts (HLF) receptors in gestational diabetes woman and to study its relationship with pregnancy induced hypertension (PIH).


METHODS
The glc-HDL was measured by fluorimetry and the specific binding of HDL to HLF receptors was measured with enzyme linked immunoreceptor assay in 32 gestational diabetic woman group 1, 34 group II, 36 normal pregnant (NP) and 32 normal non-pregnant (NNP) women.


RESULTS
The levels of glc-HDL and the intracellular total cholesterol in diabetic pregnant woman group I and II were significantly higher than those in the NP and the NNP (P < 0.01). The cell binding, internalization and degradation of glc-HDL were higher than that in the NP and the NNP.


CONCLUSIONS
The change of HDL level and lipid deposition during the process may be one of the causes for arteriole spasm in PIH.
Lipu
Qiannan Medical College of National Minorities, Duyun.
Song
Y
Y
Tian
Y
Y
D000328:Adult; D016640:Diabetes, Gestational / Q000150:complications / Q000378:metabolism*; D005260:Female; D006031:Glycosylation; D006801:Humans; D008075:Lipoproteins, HDL / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000209:etiology / Q000378:metabolism*; D011247:Pregnancy
D008075:Lipoproteins, HDL