title: Mortality from cancer of the male reproductive tract and environmental exposure to the anti-androgen p,p'-dichlorodiphenyldichloroethylene in the United States.
abstract: The association of prostate cancer mortality and testicular cancer mortality with environmental exposure to the anti-androgen dichlorodiphenyltrichloroethane (DDT) derivative p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) in the USA was explored in the period 1971-1994 using multiple linear regression analysis. Environmental p,p'-DDE contamination by state was estimated by p,p'-DDE concentrations in the subcutaneous fat of population samples and by measurements of p,p'-DDE in tree bark. On average, African Americans had adipose p,p'-DDE levels 74% higher than Whites (8.49 vs. 4.88 microg/g; p < 0.001). Neither prostate cancer mortality nor testicular cancer mortality showed a positive association with either indicator of p,p'-DDE environmental contamination. On the contrary, the regression coefficient for prostate cancer was constantly inverse for adipose p,p'-DDE along the period of study, although it approached statistical significance only for African Americans in 1981-1985 (P=-0.755; 0.10 > p > 0.05). This ecologic study does not provide support to the hypothesis of a link between environmental exposure to DDT derivatives and cancer of the male reproductive tract.
authors.affiliation: Istituto di Medicina del Lavoro, Università di Cagliari, Italy. coccop@pacs.unica.it
authors.forename: P
authors.initials: P
authors.lastname: Cocco
authors.forename: J
authors.initials: J
authors.lastname: Benichou
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data; D000368:Aged; D003633:Dichlorodiphenyl Dichloroethylene / Q000009:adverse effects* / Q000378:metabolism; D004781:Environmental Exposure / Q000009:adverse effects*; D005834:Genital Neoplasms, Male / Q000139:chemically induced* / Q000208:ethnology / Q000401:mortality*; D006801:Humans; D007182:Income; D007306:Insecticides / Q000009:adverse effects*; D016014:Linear Models; D008297:Male; D017533:Marital Status; D008875:Middle Aged; D014481:United States / Q000453:epidemiology; D044465:White People / Q000706:statistics & numerical data
chemical_list: D007306:Insecticides; D003633:Dichlorodiphenyl Dichloroethylene