title: Henoch-Schoenlein purpura and acute interstitial nephritis after intravenous vancomycin administration in a patient with a staphylococcal infection.
abstract: We describe a case of Henoch-Schoenlein purpura, associated with oliguric acute renal failure due to acute interstitial nephritis histologically proven, in a patient with a staphylococcal chest infection. The clinical syndrome appeared twice after vancomycin administration and yielded on the withdrawal of the drug. As pathogenetic mechanism we propose an anaphylactoid reaction either to vancomycin or to a staphylococcal glycoprotein released after breakdown of the microbial cells caused by vancomycin.
authors.affiliation: Department of Nephrology, Laikon General Hospital, Athens, Greece.
authors.forename: S
authors.initials: S
authors.lastname: Michail
authors.forename: G
authors.initials: G
authors.lastname: Vaiopoulos
authors.forename: L
authors.initials: L
authors.lastname: Nakopoulou
authors.forename: C
authors.initials: C
authors.lastname: Revenas
authors.forename: K
authors.initials: K
authors.lastname: Aroni
authors.forename: P
authors.initials: P
authors.lastname: Karam
authors.forename: C
authors.initials: C
authors.lastname: Stathakis
authors.forename: T
authors.initials: T
authors.lastname: Thosios
mesh_terms: D000208:Acute Disease; D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D005920:Glomerular Mesangium / Q000473:pathology; D006801:Humans; D011695:IgA Vasculitis / Q000139:chemically induced* / Q000473:pathology; D007275:Injections, Intravenous; D008297:Male; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000473:pathology; D012867:Skin / Q000473:pathology; D013203:Staphylococcal Infections / Q000188:drug therapy*; D014640:Vancomycin / Q000009:adverse effects*
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin