Stereocilia-like structures in the endolymphatic sac in Ménière's disease and acoustic neuroma.
The vestibular aqueduct was surgically removed in 3 patients undergoing labyrinthectomy due to severe Ménière's disease (MD). Stereocilia-like structures were found in the luminal contents of the endolymphatic sac (ES) in all of these patients. The ES from 18 patients with acoustic neuroma were used as controls. In 1 of these, numerous stereocilia-like structures were found in the ES and in 3 additional patients, a few isolated cilia-like structures were disclosed. The findings may suggest an ongoing hair cell degeneration in the inner ear that is more advanced in patients with MD. The data also suggest that the endolymphatic duct is patent and that a longitudinal flow of endolymph also occurs in patients with MD.
Danckwardt-Lillieström
N
N
Department of Otolaryngology, Head and Neck Surgery, University Hospital, Uppsala, Sweden. niklas.danckwardt@uas.ent.se
Friberg
U
U
Kinnefors
A
A
Rask-Andersen
H
H
D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D001299:Audiometry; D002923:Cilia / Q000648:ultrastructure*; D004712:Endolymphatic Sac / Q000473:pathology / Q000502:physiology / Q000648:ultrastructure*; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage; D006198:Hair Cells, Auditory / Q000473:pathology* / Q000648:ultrastructure; D006319:Hearing Loss, Sensorineural / Q000209:etiology; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000150:complications / Q000473:pathology* / Q000628:therapy; D017348:Microscopy, Electron, Scanning Transmission; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000150:complications / Q000473:pathology* / Q000628:therapy; D014717:Vertigo / Q000209:etiology
D000900:Anti-Bacterial Agents; D005839:Gentamicins