title: [Hematuria, dysuria, pollakiuria and general malaise, in a patient treated with BCG instillations].
abstract: OBJECTIVE
  To report a case of granulomatous cystitis in a patient receiving bacillus Calmette-Guerin intravesical therapy for urothelial carcinoma in situ.
  
  
  METHODS
  A 58-year-old man undergoing BCG intravesical therapy for urothelial carcinoma in situ presented symptoms of intense cystitis. Cystoscopy was performed and several bladder cold biopsies were obtained.
  
  
  RESULTS
  Histopathological analysis demonstrated epithelioid granulomas.
  
  
  CONCLUSIONS
  Cystitis arising from BCG therapy is defined as drug-induced or BCG-induced cystitis. Intense cystitis and malaise are a serious complication since it is not possible to distinguish patients with a simple uncomplicated local reaction from those who will develop progressive systemic infection. Cystoscopy and biopsy can be helpful in determining the nature of the condition and are recommended.
authors.affiliation: Servicio de Anatomía Patológica, Hospital de la Merced, Sevilla, España.
authors.forename: M
authors.initials: M
authors.lastname: Medina Pérez
authors.forename: M
authors.initials: M
authors.lastname: Sánchez González
authors.forename: A
authors.initials: A
authors.lastname: Espino Montoro
mesh_terms: D000276:Adjuvants, Immunologic / Q000009:adverse effects*; D000283:Administration, Intravesical; D000368:Aged; D001500:BCG Vaccine / Q000009:adverse effects*; D002295:Carcinoma, Transitional Cell / Q000628:therapy*; D006417:Hematuria / Q000209:etiology*; D006801:Humans; D008297:Male; D001749:Urinary Bladder Neoplasms / Q000628:therapy*; D014555:Urination Disorders / Q000209:etiology*
chemical_list: D000276:Adjuvants, Immunologic; D001500:BCG Vaccine
vernacular_title: Hematuria, disuria, polaquiuria y malestar general, en paciente tratado con instilaciones de BCG.