Donor lymphocyte transfusion for the treatment of Epstein-Barr virus-associated lymphoproliferative disorder of the brain.
EBV-associated lymphoproliferative disorder (LPD) is a rare but serious complication in marrow transplant recipients. A 31-year-old Japanese woman in the second chronic phase of CML received an allogeneic BMT from her HLA 2-locus-incompatible 62-year-old father. Around day +200, she developed EBV-LPD of the right parieto-temporal lobe which caused slowly progressive left hemiparesis. Two courses of donor lymphocyte transfusions (DLT) of 10(6)CD3+ T cells/kg of body weight failed to suppress her central nervous system (CNS) EBV-LPD. The patient died of recurrent blastic crisis of CML. This case suggests that DLT may be ineffective for the treatment of CNS EBV-LPD.
Nagafuji
K
K
Department of Hematology, Hara Sanshin General Hospital, Fukuoka, Japan.
Eto
T
T
Hayashi
S
S
Oshima
K
K
Maeda
Y
Y
Gondo
H
H
Inamura
T
T
Niho
Y
Y
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D001927:Brain Diseases / Q000209:etiology* / Q000473:pathology / Q000628:therapy*; D017809:Fatal Outcome; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology; D004854:Herpesvirus 4, Human / Q000472:pathogenicity*; D006801:Humans; D015466:Leukemia, Myeloid, Chronic-Phase / Q000628:therapy; D017710:Lymphocyte Transfusion; D008232:Lymphoproliferative Disorders / Q000209:etiology* / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D014019:Tissue Donors; D014184:Transplantation, Homologous