title: A case of chromoblastomycosis due to Phialophora verrucosa responding to treatment with fluconazole.
abstract: We report the case of a 40-year-old Filippino woman, with a 5-year history of a slowly spreading, painful skin lesion on her left foot. Histological examination showed a dermal, granulomatous infiltrate consisting of neutrophils, histiocytes and lymphocytes, with "sclerotic bodies" in the cytoplasm of phagocytic cells. Mycological culture revealed the presence of Phialophora verrucosa and confirmed the histopathological diagnosis of chromo-blastomycosis. Association of surgical curettage of the exuberant, infected tissue with systemic fluconazole administration gave good therapeutic results with no relevant side effects.
authors.affiliation: Department of Dermatology, Università Cattolica del Sacro Cuore, Largo A. Gemelli, 8, 00168 Roma, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Guerriero
authors.forename: C
authors.initials: C
authors.lastname: De Simone
authors.forename: A
authors.initials: A
authors.lastname: Tulli
mesh_terms: D000328:Adult; D002862:Chromoblastomycosis / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use*; D005533:Foot Dermatoses / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D006801:Humans; D010676:Phialophora / Q000302:isolation & purification
chemical_list: D015725:Fluconazole