Uncoupling proteins: beyond brown adipose tissue.
Uncoupling protein, originally described in the inner mitochondrial membrane of brown adipose tissue, permits the oxidation of fuels without the generation of adenosine triphosphate (ATP). Closely related proteins have now been found in many other tissues and shown to be regulated by thyroid hormones and dietary factors. These uncoupling proteins may play a significant role in energy expenditure, with implications for the development of human obesity.
Freake
H C
HC
Department of Nutritional Sciences, University of Connecticut, Storrs 06269-4017, USA.
D002001:Adipose Tissue, Brown / Q000378:metabolism*; D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000502:physiology; D004032:Diet; D015870:Gene Expression; D006801:Humans; D007473:Ion Channels; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology; D024101:Mitochondrial Proteins; D009765:Obesity / Q000209:etiology*; D012333:RNA, Messenger / Q000032:analysis; D013963:Thyroid Hormones / Q000494:pharmacology; D014018:Tissue Distribution; D000071256:Uncoupling Protein 1
D002352:Carrier Proteins; D007473:Ion Channels; D008565:Membrane Proteins; D024101:Mitochondrial Proteins; D012333:RNA, Messenger; D013963:Thyroid Hormones; D000071256:Uncoupling Protein 1