Multiple myeloma-associated amyloidosis and giant cell arteritis.
Primary systemic amyloidosis has been associated with the development of symptoms and clinical features characteristic of polymyalgia rheumatica and/or giant cell arteritis (GCA). Case reports of this clinical entity have been published, stating that the amyloid deposition leads to the symptoms of vasculitis. In this report, we present a second case in the English literature of a patient presenting with multiple myeloma-associated amyloidosis and GCA. This is the first case in which the histopathologic findings are described in enough detail to suggest a pathogenic relationship between the two diseases.
Estrada
A
A
Duke University Medical Center, Durham, North Carolina 27710, USA.
Stenzel
T T
TT
Burchette
J L
JL
Allen
N B
NB
D000368:Aged; D000686:Amyloidosis / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D001402:B-Lymphocytes / Q000166:cytology; D017809:Fatal Outcome; D005260:Female; D013700:Giant Cell Arteritis / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D008264:Macrophages / Q000166:cytology; D009101:Multiple Myeloma / Q000175:diagnosis*; D013601:T-Lymphocytes / Q000166:cytology