title: Effect of intravenous vasopressin on endocochlear potential and systemic blood pressure in the guinea pig.
abstract: The effects of intravenous arginine-vasopressin (AVP) on the endocochlear potential (EP) and systemic blood pressure (BP) were examined in the guinea pig. Intravenous AVP (10(-7) M) elevated BP significantly but did not change EP. AVP (10(-8) M) produced a significant decrease in the amplitude of EP but did not change mean blood pressure significantly. AVP at 10(-9) M did not affect EP or BP. These results suggest that intravenous AVP might have an inhibitory effect on EP.
authors.affiliation: Department of Otolaryngology, Nara Medical University, Kashihara City, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nario
authors.forename: T
authors.initials: T
authors.lastname: Ueda
authors.forename: T
authors.initials: T
authors.lastname: Murai
authors.forename: H
authors.initials: H
authors.lastname: Miyahara
authors.forename: T
authors.initials: T
authors.lastname: Matsunaga
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000008:administration & dosage / Q000494:pharmacology* / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D003055:Cochlear Microphonic Potentials / Q000187:drug effects* / Q000502:physiology; D006168:Guinea Pigs; D007262:Infusions, Intravenous; D014662:Vasoconstrictor Agents / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D014662:Vasoconstrictor Agents; D001127:Arginine Vasopressin