title: Risperidone for aggression and self-injurious behavior in adults with mental retardation.
abstract: Risperidone has proven efficacy with reduced likelihood of causing extrapyramidal symptoms in the treatment of schizophrenia. Initial work suggests its utility in the management of aggression and self injury in patients with mental retardation. The use of risperidone in eight adult patients with moderate to profound mental retardation is described. Risperidone in these individuals was associated with significant reduction in aggression and self injurious behavior. Side effects were primarily those of sedation and restlessness. These cases illustrate the possible utility of risperidone in the treatment of aggression and self injury in adult patients with moderate to profound mental retardation.
authors.affiliation: Fircrest School, Seattle, Washington, USA.
authors.forename: S A
authors.initials: SA
authors.lastname: Cohen
authors.forename: K
authors.initials: K
authors.lastname: Ihrig
authors.forename: R S
authors.initials: RS
authors.lastname: Lott
authors.forename: J M
authors.initials: JM
authors.lastname: Kerrick
mesh_terms: D000328:Adult; D000374:Aggression / Q000187:drug effects* / Q000523:psychology; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001521:Behavior Therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000523:psychology / Q000534:rehabilitation*; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination / Q000187:drug effects; D018967:Risperidone / Q000009:adverse effects / Q000627:therapeutic use*; D016728:Self-Injurious Behavior / Q000523:psychology / Q000534:rehabilitation*; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D018967:Risperidone