title: Clear cell carcinoma of the pancreas: an adenocarcinoma with ductal phenotype.
abstract: OBJECTIVE
  Primary clear cell carcinoma of the pancreas resembling metastatic renal carcinoma has only rarely been described. To date it has been poorly characterized as a distinct tumour entity.
  
  
  RESULTS
  We report a case of clear cell carcinoma in a 53-year-old man involving the head of the pancreas and which had a small intraductal papillary component. The clear cell portion comprised about 90% of the tumour mass. It showed predominantly a solid growth pattern with a few scattered tubular structures. Immunocytochemically the tumour cells stained positively for cytokeratins 7, 8, 18 and 19, whereas the reaction for vimentin and neuroendocrine markers was negative. K-ras analysis revealed a point mutation at codon 12 with mutation of GGT to GAT.
  
  
  CONCLUSIONS
  The intraductal tumour component of this clear cell carcinoma as well as the cytokeratin pattern and the K-ras mutation suggest that this rare type of pancreatic cancer has a ductal phenotype.
authors.affiliation: Department of Pathology, University of Kiel, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Lüttges
authors.forename: I
authors.initials: I
authors.lastname: Vogel
authors.forename: M
authors.initials: M
authors.lastname: Menke
authors.forename: D
authors.initials: D
authors.lastname: Henne-Bruns
authors.forename: B
authors.initials: B
authors.lastname: Kremer
authors.forename: G
authors.initials: G
authors.lastname: Klöppel
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D011905:Genes, ras / Q000235:genetics; D006801:Humans; D007124:Immunoenzyme Techniques; D007633:Keratins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D017354:Point Mutation; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
chemical_list: D016159:Tumor Suppressor Protein p53; D007633:Keratins