title: Dancing eye syndrome and hyperphosphatasemia.
abstract: An 11-month-old boy with a relapsing dancing eye syndrome associated with elevation of serum alkaline phosphatase, lactate dehydrogenase, and aminotransferase activities is reported. During two clinical episodes the serum alkaline phosphatase activity increased up to four times the upper reference limit, remained elevated for a few weeks and normalized gradually in parallel with clinical improvement under steroid therapy. We found no evidence of liver or bone pathology nor of a neural crest tumor. The association between dancing eye syndrome and hyperphosphatasemia has not yet been described. The beneficial effect of the steroid therapy strengthens the hypothesis of an autoimmune origin.
authors.affiliation: Department of Pediatrics, Academisch Ziekenhuis-Kinderen Vrije Universiteit Brussel, Brussels, Belgium.
authors.forename: D E
authors.initials: DE
authors.lastname: Hasaerts
authors.forename: F K
authors.initials: FK
authors.lastname: Gorus
authors.forename: L J
authors.initials: LJ
authors.lastname: De Meirleir
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001842:Bone and Bones / Q000201:enzymology; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008099:Liver / Q000201:enzymology; D008297:Male; D009207:Myoclonus / Q000188:drug therapy / Q000201:enzymology*; D015835:Ocular Motility Disorders / Q000188:drug therapy / Q000201:enzymology*; D011239:Prednisolone / Q000627:therapeutic use; D013577:Syndrome
chemical_list: D000893:Anti-Inflammatory Agents; D011239:Prednisolone; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase