Estrogen-induced tumorigenesis in the pituitary gland of TGF-beta(+/-) knockout mice.
Transforming growth factor (TGF)-beta receptor type II gene (Tgfbr2) knockout and wild type mice underwent chronic estrogen exposure using estradiol pellets. Histological examination of the pituitary glands found 38 adenomas in 14 Tgfbr2(+/-) mice but only one tumor in ten wild type mice. Pituitary tumorigenesis is greatly accelerated in Tgfbr2(+/-) mice by estrogen treatment.
Shida
N
N
Department of Neurosurgery, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980, Japan.
Ikeda
H
H
Yoshimoto
T
T
Oshima
M
M
Taketo
M M
MM
Miyoshi
I
I
D000236:Adenoma / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D004958:Estradiol / Q000494:pharmacology*; D006579:Heterozygote; D051379:Mice; D018345:Mice, Knockout; D010911:Pituitary Neoplasms / Q000139:chemically induced* / Q000473:pathology; D017346:Protein Serine-Threonine Kinases; D000077294:Receptor, Transforming Growth Factor-beta Type II; D018125:Receptors, Transforming Growth Factor beta / Q000032:analysis / Q000235:genetics*
D018125:Receptors, Transforming Growth Factor beta; D004958:Estradiol; D017346:Protein Serine-Threonine Kinases; D000077294:Receptor, Transforming Growth Factor-beta Type II