title: Development of a pediatric liver transplantation program in Argentina.
abstract: This article describes the preliminary experimental steps and clinical implementation of a purely pediatric liver transplantation (LT) program in a large public children's hospital in Buenos Aires, Argentina, a city with well over 10 million inhabitants and a referral population of over 30 million. Between 1993 and 1997, 84 LTs were performed in 81 patients, of which one-fourth weighed below 10 kg. The main indications were biliary atresia (n = 25, 30%) and fulminant liver failure (n = 23, 27%), followed by autoimmune cirrhosis (n = 14, 16%) and other liver diseases. Shortage of organs due to local conditions led to the use of liver-reduction techniques in 48 cases (57%), split liver in 2, and living-related donor (LRD) in 2. Retransplantation was necessary in 3 instances. Seventy-eight percent of the recipients survived for more than 1 year and 71% were alive after 4 years. The authors comment on the need for adaptation to local conditioning factors when developing a pediatric LT program in any country in which demographics and economic, medical, and sociological environments have a decisive influence on organ procurement, the actual performance of the operation, and the lifelong postoperative medication. In Buenos Aires, where the hospital setting is well-developed, the indications are in part determined by the high incidence of hepatitis A. Organ shortages in our area led to liberal use of liver reduction, split-liver, and LRD techniques. The overall results of the first years of such a program were largely satisfactory.
authors.affiliation: Hospital Juan P. Garrahan, Buenos Aires, Argentina.
authors.forename: E
authors.initials: E
authors.lastname: Williams
authors.forename: H
authors.initials: H
authors.lastname: Questa
authors.forename: V
authors.initials: V
authors.lastname: Wacholder
authors.forename: L
authors.initials: L
authors.lastname: Rojas
authors.forename: G
authors.initials: G
authors.lastname: Cervio
authors.forename: G
authors.initials: G
authors.lastname: Bianco
authors.forename: O
authors.initials: O
authors.lastname: Imventarza
mesh_terms: D001118:Argentina; D002648:Child; D006801:Humans; D017114:Liver Failure, Acute / Q000209:etiology / Q000601:surgery; D016031:Liver Transplantation / Q000401:mortality / Q000592:standards; D008297:Male; D016730:Program Development; D012189:Retrospective Studies; D015996:Survival Rate; D014019:Tissue Donors