title: Defects of lipoprotein metabolism in familial combined hyperlipidaemia.
abstract: Familial combined hyperlipidaemia is the most common inherited hyperlipidaemia and is found in up to 10% of patients with premature myocardial infarction. The genetic and metabolic bases of the disorder have not yet been defined. This review discusses the important advances in the past year in our understanding of the different metabolic pathways contributing to the pathogenesis of familial combined hyperlipidaemia.
authors.affiliation: Department of Medicine, University Hospital Nijmegen, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: de Graaf
authors.forename: A F
authors.initials: AF
authors.lastname: Stalenhoef
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D053299:Apolipoprotein B-100; D053304:Apolipoprotein C-II; D053305:Apolipoprotein C-III; D001055:Apolipoproteins B / Q000378:metabolism; D001056:Apolipoproteins C / Q000378:metabolism; D006801:Humans; D006950:Hyperlipidemia, Familial Combined / Q000209:etiology / Q000378:metabolism*; D007333:Insulin Resistance; D008071:Lipoprotein Lipase / Q000378:metabolism; D008074:Lipoproteins / Q000378:metabolism*; D008077:Lipoproteins, LDL / Q000378:metabolism
chemical_list: D053299:Apolipoprotein B-100; D053304:Apolipoprotein C-II; D053305:Apolipoprotein C-III; D001055:Apolipoproteins B; D001056:Apolipoproteins C; D008074:Lipoproteins; D008077:Lipoproteins, LDL; D008071:Lipoprotein Lipase