title: Aberrant cell division and random FtsZ ring positioning in Escherichia coli cpxA* mutants.
abstract: In Escherichia coli, certain mutations in the cpxA gene (encoding a sensor kinase of a two-component signal transduction system) randomize the location of FtsZ ring assembly and dramatically affect cell division. However, deletion of the cpxRA operon, encoding the sensor kinase and its cognate regulator CpxR, has no effect on division site biogenesis. It appears that certain mutant sensor kinases (CpxA*) either exhibit hyperactivity on CpxR or extend their signalling activity to one or more noncognate response regulators involved in cell division.
authors.affiliation: Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: J
authors.initials: J
authors.lastname: Pogliano
authors.forename: J M
authors.initials: JM
authors.lastname: Dong
authors.forename: P
authors.initials: P
authors.lastname: De Wulf
authors.forename: D
authors.initials: D
authors.lastname: Furlong
authors.forename: D
authors.initials: D
authors.lastname: Boyd
authors.forename: R
authors.initials: R
authors.lastname: Losick
authors.forename: K
authors.initials: K
authors.lastname: Pogliano
authors.forename: E C
authors.initials: EC
authors.lastname: Lin
mesh_terms: D001426:Bacterial Proteins / Q000032:analysis / Q000096:biosynthesis*; D002455:Cell Division; D002872:Chromosome Deletion; D002876:Chromosomes, Bacterial; D003598:Cytoskeletal Proteins; D004926:Escherichia coli / Q000166:cytology* / Q000235:genetics* / Q000648:ultrastructure; D029968:Escherichia coli Proteins; D019204:GTP-Binding Proteins / Q000096:biosynthesis; D005838:Genotype; D008854:Microscopy, Electron; D009876:Operon; D011494:Protein Kinases / Q000235:genetics*; D015398:Signal Transduction
chemical_list: D001426:Bacterial Proteins; D003598:Cytoskeletal Proteins; D029968:Escherichia coli Proteins; C071525:FtsZ protein, Bacteria; D011494:Protein Kinases; C490475:CpxA protein, E coli; C092472:CpxA protein, bacteria; D019204:GTP-Binding Proteins