An experimental comparative study on the characteristics of ventricular fibrillation during cardiac arrest and methoxamine administration.
The effect of a pure alpha-adrenergic agent, methoxamine on ventricular fibrillation (VF) amplitude and the relation between hemodynamic parameters and survival in a rodent cardiopulmonary resuscitation (CPR) model were studied. Our results suggested that: 1) VF amplitude decreased during untreated VF, but it increased during pericardial chest compression: 2) methoxamine significantly increased the mean aortic pressure (MAP) and coronary perfusion pressure (CPP) but not VF amplitude, and the survival also increased due to elevation of CPP; and 3) all surviving animals with successful defibrillation had a higher VF amplitude.
Pan
T
T
Department of Thoracic and Cardiac Surgery, Tongji Hospital, Tongji Medical University, Wuhan. Wuhan.
Chau
S
S
Von Planta
M
M
Studer
W
W
Scheidgger
D
D
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D016887:Cardiopulmonary Resuscitation; D004554:Electric Countershock; D006323:Heart Arrest / Q000503:physiopathology*; D008297:Male; D008729:Methoxamine / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014693:Ventricular Fibrillation / Q000503:physiopathology*
D000316:Adrenergic alpha-Agonists; D008729:Methoxamine