title: Syndromes of thrombosis and hypercoagulability. Congenital and acquired causes of thrombosis.
abstract: Blood coagulation protein and platelet defects are now known to account for up to ninety percent of unexplained venous thrombosis and up to seventy percent of unexplained arterial thrombotic or ischemic events. This article summarizes the common and uncommon blood protein and platelet defects which should be suspected, and searched for, in patients with such events. Defining such defects will have major impact on secondary prevention and duration of antithrombotic therapy in the afflicted patient and impact on primary prevention for identified family members in those harboring hereditary defects.
authors.affiliation: Department of Medicine (Hematology/Oncology), University of Texas Southwestern Medical Center, Dallas 75231, USA.
authors.forename: R L
authors.initials: RL
authors.lastname: Bick
authors.forename: H
authors.initials: H
authors.lastname: Kaplan
mesh_terms: D016736:Antiphospholipid Syndrome / Q000097:blood / Q000151:congenital / Q000209:etiology; D000991:Antithrombins / Q000172:deficiency; D001778:Blood Coagulation Disorders / Q000097:blood / Q000151:congenital / Q000209:etiology*; D001791:Blood Platelet Disorders / Q000097:blood / Q000151:congenital / Q000209:etiology; D005342:Fibrinolysis; D015844:Heparin Cofactor II / Q000172:deficiency; D006801:Humans; D020151:Protein C Deficiency; D018455:Protein S Deficiency / Q000097:blood / Q000151:congenital / Q000209:etiology; D013577:Syndrome; D013927:Thrombosis / Q000097:blood / Q000151:congenital / Q000209:etiology*
chemical_list: D000991:Antithrombins; D015844:Heparin Cofactor II