Anthraquinones from Neonauclea calycina and their inhibitory activity against DNA topoisomerase II.
In a series of searches for DNA topoisomerase II inhibitors from naturally occurring compounds, a wood extract of Neonauclea calycina MERR. (Rubiaceae) showed a moderate effect in vitro. Purification of the extract resulted in the isolation of seven known anthraquinones. The structures were characterized as damnacanthal, rubiadin 1-methyl ether, nordamnacanthal, morindone, damnacanthol, lucidin 3-O-primeveroside and morindone 6-O-primeveroside by spectral analysis, respectively. Damnacanthal and morindone showed an intensive inhibitory effect against topoisomerase II (IC50: 20 micrograms/ml and 21 micrograms/ml).
Tosa
H
H
Department of Pharmacognosy, Gifu Pharmaceutical University, Japan.
Iinuma
M
M
Asai
F
F
Tanaka
T
T
Nozaki
H
H
Ikeda
S
S
Tsutsui
K
K
Tsutsui
K
K
Yamada
M
M
Fujimori
S
S
D000880:Anthraquinones / Q000737:chemistry / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D059005:Topoisomerase II Inhibitors; D014197:Trees / Q000737:chemistry*
D000880:Anthraquinones; D000972:Antineoplastic Agents, Phytogenic; D004791:Enzyme Inhibitors; D010936:Plant Extracts; D059005:Topoisomerase II Inhibitors; C575654:morindone