title: Potent retinoid synergists with a diphenylamine skeleton.
abstract: 4-[N-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)amino]benzoic acid (5) exhibited weak retinoidal and retinoid synergistic activities in HL-60 cell differentiation assay. N-Alkylation of 5 caused decrease or loss of differentiation-inducing activity, but enhanced the synergistic activity with a synthetic retinoid Am80 (2), as reflected in the potent synergistic EC50 (SEC50) values of DA023 (11, 1.6 x 10(-10) M) and DA113 (14, 1.4 x 10(-10) M) in the presence of 1.0 x 10(-10) M Am80 (2).
authors.affiliation: Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ohta
authors.forename: M
authors.initials: M
authors.lastname: Tsuji
authors.forename: E
authors.initials: E
authors.lastname: Kawachi
authors.forename: H
authors.initials: H
authors.lastname: Fukasawa
authors.forename: Y
authors.initials: Y
authors.lastname: Hashimoto
authors.forename: K
authors.initials: K
authors.lastname: Shudo
authors.forename: H
authors.initials: H
authors.lastname: Kagechika
mesh_terms: D002454:Cell Differentiation / Q000187:drug effects; D004159:Diphenylamine / Q000494:pharmacology*; D004357:Drug Synergism; D018922:HL-60 Cells; D006801:Humans; D012176:Retinoids / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D012176:Retinoids; D004159:Diphenylamine