title: Rifabutin-associated uveitis in an immunosuppressed pediatric patient without acquired immunodeficiency syndrome.
abstract: OBJECTIVE
  To describe a case of bilateral, symptomatic rifabutin-associated uveitis with hypopyon and vitreal opacities in an immunosuppressed pediatric patient without acquired immunodeficiency syndrome (AIDS).
  
  
  METHODS
  Case report. An 8-year-old boy presented with bilateral uveitis 24 months after a bilateral lung transplant.
  
  
  RESULTS
  Our patient, whose medications included rifabutin, clarithromycin, and immunosuppressive agents, responded to discontinuation of the rifabutin and initiation of intensive topical corticosteroid therapy with complete resolution of the uveitis.
  
  
  CONCLUSIONS
  Rifabutin-associated uveitis may occur in a non-AIDS pediatric patient.
authors.affiliation: Edward S. Harkness Eye Institute, Columbia Presbyterian Medical Center, New York, NY 10032, USA. daj17@columbia.edu
authors.forename: D A
authors.initials: DA
authors.lastname: Jewelewicz
authors.forename: W M
authors.initials: WM
authors.lastname: Schiff
authors.forename: S
authors.initials: S
authors.lastname: Brown
authors.forename: G R
authors.initials: GR
authors.lastname: Barile
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D000904:Antibiotics, Antitubercular / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D005128:Eye Diseases / Q000139:chemically induced; D006801:Humans; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D008171:Lung Diseases / Q000188:drug therapy / Q000382:microbiology; D016040:Lung Transplantation; D008297:Male; D015270:Mycobacterium avium-intracellulare Infection / Q000188:drug therapy / Q000382:microbiology; D017828:Rifabutin / Q000009:adverse effects* / Q000627:therapeutic use; D014605:Uveitis / Q000139:chemically induced*; D014822:Vitreous Body / Q000187:drug effects*
chemical_list: D000904:Antibiotics, Antitubercular; D007166:Immunosuppressive Agents; D017828:Rifabutin