[Acne induced by amineptin: adnexal toxiderma].
BACKGROUND
Amineptine-induced acne is a classical side effect often encountered after prolonged and excessive use of the antidepressor.


METHODS
We report the case of a young female drug addict (benzodiazepines and alcohol) who denied overuse of amineptine. The initial inflammatory aspect of the lesion was unusual as was the histology report. The sebaceous glands were the site of cystic dilatation as would be expected, but in addition the sudoriparous glands showed keratinizing syringometaplasia with areas of neutrophilic eccrine hidradenitis.


CONCLUSIONS
This is the second report of such a case similar to other due to chemotherapy, benaxoprofene or toxic agents for example, and corresponds to direct toxicity to the sudoriparous glands which accumulate amineptine. We therefore propose the term of adnexal toxic drug eruption.
Huet
P
P
Service de Dermatologie, Hôpital Caremeau, CHRU Nîmes.
Dandurand
M
M
Joujoux
J M
JM
Amaudric
F
F
Guillot
B
B
D000152:Acne Vulgaris / Q000139:chemically induced* / Q000473:pathology; D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects*; D003986:Dibenzocycloheptenes / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D005148:Facial Dermatoses / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D007049:Iatrogenic Disease
D000929:Antidepressive Agents, Tricyclic; D003986:Dibenzocycloheptenes; C011597:amineptin
L'acné induite par l'amineptine: une toxidermie annexielle.