Enhancement of NO production in activated macrophages in vivo by an antimalarial crude drug, Dichroa febrifuga.
The effect of an antimalarial crude drug, Dichroafebrifuga Lour. on nitric oxide (NO) production in bacillus Calmette Guérin-induced mouse peritoneal macrophages activated by lipopolysaccharide was investigated. The NO production was significantly enhanced by an oral administration of a MeOH extract of D. febrifuga. Febrifugine (1) was isolated as the main active compound, and the activation was dose-dependent in the dosage range of 0.1-1 mg/kg/day.
Murata
K
K
Department of Pharmacognosy, and Experimental Station for Medicinal Plant Studies, Faculty of Pharmaceutical Sciences, Tohoku University, Aoba-yama, Aoba-ku, Sendai 980-77, Japan.
Takano
F
F
Fushiya
S
S
Oshima
Y
Y
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D002681:China; D066298:In Vitro Techniques; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D008813:Mice, Inbred ICR; D009569:Nitric Oxide / Q000096:biosynthesis*; D010880:Piperidines; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011799:Quinazolines / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000962:Antimalarials; D010880:Piperidines; D010936:Plant Extracts; D011799:Quinazolines; D009569:Nitric Oxide; C001207:febrifugine