A model of subarachnoid cavity drugs perfusion and its clinical application in treatment of spinal cord injury.
An animal model of subarachnoid cavity drugs perfusion and its prelimilary clinical application in treatment of acute spinal cord injury (SCI) were reported. Analysis of the heart rate (HR), ECG blood pressure (CVP, CAP) cerebrospinal fluid (CSF) pressuer and CSF gas and pH values of 10 healthy adult goats during subarachnoid daxamethasone verapamil perfusion showed that this model was safe anti reliable. 26 patients with acute SCI were selected for a clinical obseration. Good results were obtained in 7 cases who received this treatment of subarachnoid cavity perfusion with dexamethasone and verapamil.
Du
J
J
Department of Orthopedics, Xiehe Hospital, Tongji Medical University, Wuhan.
Xia
Z
Z
Tu
Y
Y
Wang
L
L
D000293:Adolescent; D000328:Adult; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D002121:Calcium Channel Blockers / Q000008:administration & dosage*; D002404:Catheterization; D003907:Dexamethasone / Q000008:administration & dosage*; D005260:Female; D006041:Goats; D006801:Humans; D008297:Male; D013119:Spinal Cord Injuries / Q000188:drug therapy*; D013346:Subarachnoid Space; D014700:Verapamil / Q000008:administration & dosage*
D000893:Anti-Inflammatory Agents; D002121:Calcium Channel Blockers; D003907:Dexamethasone; D014700:Verapamil