[Potentiometric electrodes for determining choline, butyrylcholine and cholinesterase inhibitors].
Potentiometric choline electrodes were developed on the basis of the mediator-free bioelectrocatalysis. The electrodes made of a composite carbon-polymer material contain choline oxidase and peroxidase coimmobilized on the surface of the electrode. The rate of the potential increase was shown to be proportional to the choline concentration within a broad range of variation. Coupling of choline-sensitive electrodes with butyrylcholinesterase makes possible both the direct detection of butyrylcholine and analysis of butyrylcholinesterase inhibitors.
Gindilis
A L
AL
All-Russia Research Center for Molecular Diagnosis and Treatment, Moscow, Russia.
Kurochkin
I N
IN
D002091:Butyrylcholinesterase / Q000187:drug effects; D002384:Catalysis; D002794:Choline / Q000031:analogs & derivatives* / Q000032:analysis*; D002800:Cholinesterase Inhibitors / Q000032:analysis*; D004566:Electrodes; D007700:Kinetics; D011199:Potentiometry / Q000295:instrumentation*
D002800:Cholinesterase Inhibitors; C017100:butyrylcholine; D002091:Butyrylcholinesterase; D002794:Choline
Potentsiometricheskie élektrody dlia opredeleniia kholina, butirilkholina i ingibitorov kholinésteraz.