title: High-risk gestational trophoblastic disease: analysis of clinical prognoses.
abstract: OBJECTIVE
  An attempt to better define factors leading to patient survival in the high-risk group of malignant gestational trophoblastic disease (GTD).
  
  
  METHODS
  From January 1, 1997 to December 31, 1995 25 cases of malignant high-risk GTD were retrospectively collected to evaluate prognostic factors by univariate and multivariate analysis.
  
  
  RESULTS
  We identified the presence of liver metastases and/or brain metastases and the presence of intestinal metastases as significant by using univariate analysis. However, only the presence of liver metastases of brain metastases was significant by multivariate analysis (p=0.009).
  
  
  CONCLUSIONS
  Although a high-risk group of GTD can be identified according to the modified World Health Organization (WHO) prognostic scoring system, liver metastases were not emphasized (only two points) in this scoring system. We suggested that these risk factors, including brain metastases and liver metastases, should be weighted more than other risk factors.
authors.affiliation: Department of Obstetrics and Gynecology, Veterans General Hospital-Taipei, National Yang-Ming University School of Medicine, Taiwan.
authors.forename: P H
authors.initials: PH
authors.lastname: Wang
authors.forename: C C
authors.initials: CC
authors.lastname: Yuan
authors.forename: J Y
authors.initials: JY
authors.lastname: Tseng
authors.forename: H T
authors.initials: HT
authors.lastname: Chao
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D015999:Multivariate Analysis; D011247:Pregnancy; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D014328:Trophoblastic Neoplasms / Q000401:mortality* / Q000556:secondary / Q000628:therapy; D014594:Uterine Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy