title: Therapeutic amnioinfusions and fetal fibronectin pattern in a case with preterm ruptured membranes that resealed.
abstract: OBJECTIVE
  Determination of fetal fibronectin (fFN) levels in a patient at risk of preterm delivery and having premature rupture of the membranes.
  
  
  METHODS
  The present case report concerns a pregnant woman with premature rupture of the membranes at 16 weeks of gestation who was submitted to repeated therapeutic transabdominal amnioinfusions and had a spontaneous resolution of the rupture at 32 weeks of gestation.
  
  
  RESULTS
  A good pregnancy outcome was observed. High cervicovaginal fFN levels were observed during the period of membrane rupture with following drop of fFN levels during this period and spontaneous reseal of the membranes.
  
  
  CONCLUSIONS
  Active expectant management, using repeated amnioinfusions, probably played a useful role in the therapeutic success of this pregnancy. Further, fFN was a reliable marker of the rupture of membranes. The possible role of fFN in the clinical management of high-risk pregnancies is confirmed.
authors.affiliation: Department of Obstetrics and Gynecology, Catholic University of Rome, Italy.
authors.forename: S
authors.initials: S
authors.lastname: De Carolis
authors.forename: B
authors.initials: B
authors.lastname: Carducci
authors.forename: L
authors.initials: L
authors.lastname: De Santis
authors.forename: S
authors.initials: S
authors.lastname: Ferrazzani
authors.forename: G
authors.initials: G
authors.lastname: Noia
authors.forename: A
authors.initials: A
authors.lastname: Merola
authors.forename: A
authors.initials: A
authors.lastname: Caruso
mesh_terms: D000328:Adult; D000650:Amnion; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000628:therapy*; D005333:Fetus / Q000378:metabolism*; D005353:Fibronectins / Q000378:metabolism*; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D012965:Sodium Chloride / Q000008:administration & dosage*; D012996:Solutions
chemical_list: D005353:Fibronectins; D012996:Solutions; D012965:Sodium Chloride