title: A transcriptional Map of the FMF region.
abstract: Familial Mediterranean fever (FMF) is a recessively inherited disorder characterized by attacks of fever and serositis, which affects primarily non-Ashkenazi Jews, Armenians, Turks, and Arabs. We present here a transcriptional map covering the FMF locus that we constructed in the course of the positional cloning of the gene responsible for this disease. This map was established from a contig constructed with YAC, BAC, and cosmid clones and covers about 500 kb of 16p13.3. It contains nine transcriptional units corresponding to known genes or to genes belonging to known gene families, 23 gene fragments characterized by partial sequences, and an endogenous retrovirus sequence. It thus considerably increases the number of genes in this interval and improves our knowledge concerning some of the genes or gene families present in this region. Data accumulated in this region were also used in a comparative study of different methods of exon detection.
authors.affiliation: Généthon, CNRS-URA 1922, Evry, France. bernot@genos cope.cns.fr
authors.forename: A
authors.initials: A
authors.lastname: Bernot
authors.forename: R
authors.initials: R
authors.lastname: Heilig
authors.forename: C
authors.initials: C
authors.lastname: Clepet
authors.forename: N
authors.initials: N
authors.lastname: Smaoui
authors.forename: C
authors.initials: C
authors.lastname: Da Silva
authors.forename: J L
authors.initials: JL
authors.lastname: Petit
authors.forename: C
authors.initials: C
authors.lastname: Devaud
authors.forename: N
authors.initials: N
authors.lastname: Chiannilkulchai
authors.forename: C
authors.initials: C
authors.lastname: Fizames
authors.forename: D
authors.initials: D
authors.lastname: Samson
authors.forename: C
authors.initials: C
authors.lastname: Cruaud
authors.forename: C
authors.initials: C
authors.lastname: Caloustian
authors.forename: G
authors.initials: G
authors.lastname: Gyapay
authors.forename: M
authors.initials: M
authors.lastname: Delpech
authors.forename: J
authors.initials: J
authors.lastname: Weissenbach
mesh_terms: D001483:Base Sequence; D015152:Blotting, Northern; D002874:Chromosome Mapping; D018244:Chromosomes, Artificial, Yeast; D003598:Cytoskeletal Proteins; D018076:DNA, Complementary; D005091:Exons; D010505:Familial Mediterranean Fever / Q000235:genetics*; D015870:Gene Expression; D015698:Genomic Library; D006801:Humans; D008666:Metalloendopeptidases / Q000235:genetics; D008969:Molecular Sequence Data; D011506:Proteins / Q000235:genetics; D000071198:Pyrin; D018035:Receptors, Odorant / Q000235:genetics; D015183:Restriction Mapping; D012680:Sensitivity and Specificity; D017422:Sequence Analysis, DNA; D012984:Software; D014158:Transcription, Genetic; D016335:Zinc Fingers / Q000235:genetics
chemical_list: D003598:Cytoskeletal Proteins; D018076:DNA, Complementary; C000604192:MEFV protein, human; D011506:Proteins; D000071198:Pyrin; D018035:Receptors, Odorant; D008666:Metalloendopeptidases