title: The immune system can affect learning: chronic immune complex disease in a rat model.
abstract: Evidence is presented that the immune system can affect central nervous system functioning, leading to changes in learning. Immune complex disease is induced in rats and their behavior tested using a Lashley maze. Significant differences in behavior were found between the animals with high disease activity and those with low disease activity and the non-disease controls. These changes were not due to uremia and are most likely due to the immune response. There is some evidence immune complex deposits in the choroid plexus may play some role, but not the sole or major role in the behavioral changes. This provides a model by which immunologic processes can cause neuropsychiatric manifestations in autoimmune diseases like lupus, as well as showing that immune processes can affect behavioral functioning.
authors.affiliation: Department of Microbiology and Molecular and Cell Biology Program, Arizona State University, Tempe 85287-2701, USA. atsah@asuvm.inre.asu.edu
authors.forename: S A
authors.initials: SA
authors.lastname: Hoffman
authors.forename: D W
authors.initials: DW
authors.lastname: Shucard
authors.forename: R J
authors.initials: RJ
authors.lastname: Harbeck
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D002831:Choroid Plexus / Q000276:immunology; D002908:Chronic Disease; D003071:Cognition / Q000502:physiology; D004195:Disease Models, Animal; D007105:Immune Complex Diseases / Q000276:immunology*; D007107:Immune System / Q000502:physiology*; D007678:Kidney Glomerulus / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D008568:Memory / Q000502:physiology; D009043:Motor Activity / Q000502:physiology; D015213:Neuroimmunomodulation / Q000502:physiology*; D011507:Proteinuria / Q000276:immunology; D051381:Rats; D017207:Rats, Sprague-Dawley