5-Fluoro-2-methyl-N-[4-(5H-pyrrolo[2,1-c]-[1, 4]benzodiazepin-10(11H)-ylcarbonyl)-3-chlorophenyl]benzamide (VPA-985): an orally active arginine vasopressin antagonist with selectivity for V2 receptors.
Albright
J D
JD
Wyeth-Ayerst Research, Pearl River, New York 10965, and Wyeth-Ayerst Research, Princeton, New Jersey 08543-8000, USA.
Reich
M F
MF
Delos Santos
E G
EG
Dusza
J P
JP
Sum
F W
FW
Venkatesan
A M
AM
Coupet
J
J
Chan
P S
PS
Ru
X
X
Mazandarani
H
H
Bailey
T
T
D000284:Administration, Oral; D000818:Animals; D001127:Arginine Vasopressin / Q000037:antagonists & inhibitors* / Q000172:deficiency; D001381:Azepines / Q000008:administration & dosage / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology; D001549:Benzamides / Q000008:administration & dosage / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology; D001792:Blood Platelets / Q000378:metabolism; D001834:Body Water / Q000378:metabolism; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D004285:Dogs; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D009994:Osmolar Concentration; D011758:Pyrroles; D051381:Rats; D017483:Receptors, Vasopressin / Q000378:metabolism*; D012964:Sodium / Q000097:blood; D013329:Structure-Activity Relationship; D014556:Urine / Q000737:chemistry; D001569:Benzodiazepines
D001127:Arginine Vasopressin; D001381:Azepines; D001549:Benzamides; D011758:Pyrroles; D017483:Receptors, Vasopressin; D012964:Sodium; C409452:lixivaptan; D001569:Benzodiazepines