title: Effect of chloroquine on the contractility of the smooth muscles of the rat uterus, trachea and urinary bladder.
abstract: This study was performed to investigate the effect of chloroquine (CQ) on the contractility of isolated smooth muscles of the rat uterus, urinary bladder; and trachea. Chloroquine, 4 x 10(-4) mol.l-1 completely abolished uterine contractions produced by 10(-2) IU/ml oxytocin, and 10(-6) mol.l-1 5-hydroxytryptamine (5-HT) and acetylcholine (Ach). Chloroquine also caused a concentration-dependent relaxation of 10(-6) mol.l-1 Ach-contracted rat trachea. Cumulative addition of CQ (10(-8)-10(-3) mol.l-1) to spontaneously contracting rat urinary bladder did not produce any significant effect. It also did not affect the contractile response of the bladder to Ach and 5-HT. The results suggest that CQ inhibits the contractile process in the rat uterus and trachea but not the urinary bladder.
authors.affiliation: Department of Physiology, College of Medicine, University of Lagos, Nigeria.
authors.forename: C I
authors.initials: CI
authors.lastname: Nwaigwe
authors.forename: B J
authors.initials: BJ
authors.lastname: Adegunloye
authors.forename: O A
authors.initials: OA
authors.lastname: Sofola
mesh_terms: D000818:Animals; D002738:Chloroquine / Q000494:pharmacology*; D005260:Female; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014132:Trachea / Q000187:drug effects* / Q000502:physiology; D001743:Urinary Bladder / Q000187:drug effects* / Q000502:physiology; D014590:Uterine Contraction / Q000187:drug effects*
chemical_list: D002738:Chloroquine