title: Seven-up, the Drosophila homolog of the COUP-TF orphan receptors, controls cell proliferation in the insect kidney.
abstract: Morphogenesis of the insect kidney, the Malpighian tubules, is controlled in Drosophila by a single large cell, the tip cell. It has been postulated that this cell sends out a mitogenic signal that induces the division of neighboring cells. The signal and the molecules that receive it have remained elusive. We show that the COUP-TF-related nuclear orphan receptor Seven-up is a key component that becomes induced in response to mitogenic EGF receptor signaling activity emanating from the tip cell. Seven-up in turn is capable of regulating the transcription of cell cycle regulators.
authors.affiliation: Max-Planck-Institut für Biophysikalische Chemie, Abteilung Molekulare Entwicklungsbiologie, 37077 Göttingen, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Kerber
authors.forename: S
authors.initials: S
authors.lastname: Fellert
authors.forename: M
authors.initials: M
authors.lastname: Hoch
mesh_terms: D000818:Animals; D051838:COUP Transcription Factor I; D002453:Cell Cycle / Q000235:genetics; D002455:Cell Division / Q000235:genetics / Q000502:physiology; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D004330:Drosophila / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D066246:ErbB Receptors / Q000502:physiology; D005057:Eukaryotic Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D015870:Gene Expression / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D017344:Genes, Insect / Q000235:genetics; D019476:Insect Proteins / Q000235:genetics / Q000378:metabolism; D008317:Malpighian Tubules / Q000166:cytology* / Q000254:growth & development; D008934:Mitogens / Q000494:pharmacology; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology; D011987:Receptors, Steroid / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology*
chemical_list: D051838:COUP Transcription Factor I; D004268:DNA-Binding Proteins; D019476:Insect Proteins; D008934:Mitogens; D018160:Receptors, Cytoplasmic and Nuclear; D011987:Receptors, Steroid; D014157:Transcription Factors; C094295:svp protein, Drosophila; D066246:ErbB Receptors