[The effect of calcium precipitate of double-stranded RNA on erythropoiesis in rats with acute anemia].
On the model of experimental acute anaemia of rats, induced by injection of phenilhydrazine, the influence of calcium precipitate of double-stranded RNA (Ca-ds-RNA), introduced during the crise of anaemia, on the process of erythron restoration, was studied. In the presence of Ca-ds-RNA the number of pro- and erythroblasts in fission increases by 1.5 times, compared with "pure" anaemia situation, and accordingly there is a marked decrease in the share of microcytes, which play an important role in the restoration of cell number, and in the erythron recovery after the crise of anaemia. Less pronounced is the influence of Ca-ds-RNA on the macrocytosis, which keeps its value in spite of the increase in the speed of development and of the number of normocytes after Ca-ds-RNA introduction. The mechanism of Ca-ds-RNA inclusion in the system, which controls the process of erythropoiesis during anaemia, is discussed. A conclusion is drawn that Ca-ds-RNA may directly affect the inductive stage of erythropoiesis, stimulating the formation of competent erythroid cells in population of stem haemopoiethic cells and their proliferation. Further development of bone marrow cells takes place according to the known programme of erythropoiesis whose variations are stimulated by the current conditions of its realization, but not by the presence of Ca-ds-RNA.
Magakian
Iu A
IuA
Institute of Molecular Biology, National Academy of Sciences, Republic of Armenia, Yerevan.
Karalova
E M
EM
Abroian
L O
LO
Zakharian
R A
RA
Karapetian
S A
SA
D000208:Acute Disease; D000740:Anemia / Q000097:blood* / Q000139:chemically induced / Q000473:pathology; D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D002118:Calcium / Q000737:chemistry / Q000494:pharmacology*; D002470:Cell Survival; D004920:Erythropoiesis / Q000187:drug effects*; D006454:Hemoglobins / Q000032:analysis; D010659:Phenylhydrazines / Q000633:toxicity; D012330:RNA, Double-Stranded / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats
D006454:Hemoglobins; D010659:Phenylhydrazines; D012330:RNA, Double-Stranded; C030299:phenylhydrazine; D002118:Calcium
Vliianie kal'tsievogo pretsipitata dvuspiral'noĭ RNK na éritropoéz u krys pri ostroĭ anemii.