Crossed cerebro-cellular diaschisis in a patients with melas with aphasia but without hemiparesis.
We describe a 25 year old woman diagnosed with MELAS during an acute stroke-like episode. Global aphasia, migraine-like headaches and hemi-anopsia were her main clinical features. MR imaging revealed extensive cortical and subcortical left hemispheric signal abnormalities. [Tc-99m]ECD SPECT scanning revealed crossed cerebrocerebellar diaschisis. Aphasia in the absence of gross hemiparesis can be related to cross-cerebellar diaschisis in MELAS.
Bohnen
N I
NI
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Beran-Koehn
M
M
Mullan
B
B
Fulgham
J R
JR
D000328:Adult; D001037:Aphasia / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002531:Cerebellum / Q000098:blood supply* / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation / Q000502:physiology; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006801:Humans; D017241:MELAS Syndrome / Q000000981:diagnostic imaging / Q000503:physiopathology*; D010243:Paralysis / Q000503:physiopathology; D015899:Tomography, Emission-Computed, Single-Photon