Ketotifen treatment of active colitis in patients with 5-aminosalicylate intolerance.
Mast cell stabilizers are commonly used in the treatment of asthma and allergic disorders. Although the role of mucosal mast cells in the pathogenesis of inflammatory bowel disease remains uncertain, mast cell stabilizers have been shown in animal models to attenuate the severity of experimental colitis. The authors' experience with ketotifen in three patients--one each with Crohn's disease, ulcerative colitis and collagenous colitis--who had demonstrated allergy to, or intolerance of, 5-aminosalicylic acid is reported.
Marshall
J K
JK
Department of Medicine, McMaster University, Hamilton, Ontario. marshllj@fhs.mcmaster.ca
Irvine
E J
EJ
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D003092:Colitis / Q000175:diagnosis / Q000188:drug therapy*; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D007665:Ketotifen / Q000627:therapeutic use*; D019804:Mesalamine / Q000009:adverse effects*; D008875:Middle Aged; D012074:Remission Induction; D012812:Sigmoidoscopy
D000894:Anti-Inflammatory Agents, Non-Steroidal; D006634:Histamine H1 Antagonists; D019804:Mesalamine; D007665:Ketotifen