title: Pilot study on patients' and spouses' attitudes toward potential genetic testing for bipolar disorder.
abstract: OBJECTIVE
  The purpose of this pilot study was to gain information about attitudes of individuals with bipolar disorder and their spouses toward some of the ethical and social issues arising from rapidly advancing genetic research on bipolar disorder.
  
  
  METHODS
  Patients with bipolar disorder and their unaffected spouses were asked to answer questionnaires assessing their knowledge and attitudes about treatment response rates for bipolar disorder, probability of inheritance, genetic testing, disclosure of genetic information, abortion, marriage, and child-bearing.
  
  
  RESULTS
  The overwhelming majority of the patients and spouses said that they would take advantage of genetic tests for bipolar disorder if such tests were to become available. Most patients and spouses agreed that the benefits of knowing whether one carries a gene for bipolar disorder would outweigh the risks. The decisive majority of respondents also felt that they would not abort a fetus that carried a gene for bipolar disorder. Furthermore, most patients and spouses agreed that the knowledge that one of them carried a gene for bipolar disorder would not have deterred them from marriage or childbearing.
  
  
  CONCLUSIONS
  The results of this study suggest that most individuals believe that they would benefit from the use of genetic testing for bipolar disorder if it were to become available. Follow-up studies using a broader patient sample and nonclinical control groups would be useful in further evaluating the issues addressed in this pilot study.
authors.affiliation: Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: C L
authors.initials: CL
authors.lastname: Trippitelli
authors.forename: K R
authors.initials: KR
authors.lastname: Jamison
authors.forename: M F
authors.initials: MF
authors.lastname: Folstein
authors.forename: J J
authors.initials: JJ
authors.lastname: Bartko
authors.forename: J R
authors.initials: JR
authors.lastname: DePaulo
mesh_terms: D000025:Abortion, Eugenic / Q000523:psychology; D001294:Attitude to Health; D001675:Bioethics; D001714:Bipolar Disorder / Q000235:genetics* / Q000517:prevention & control / Q000523:psychology*; D030881:Disclosure; D005260:Female; D005817:Genetic Counseling; D030661:Genetic Privacy; D005820:Genetic Testing; D006801:Humans; D008297:Male; D008393:Marriage / Q000523:psychology*; D028642:Persons with Psychiatric Disorders; D008875:Middle Aged; D033242:Minors; D010342:Patient Acceptance of Health Care; D010865:Pilot Projects; D011336:Probability; D018570:Risk Assessment; D012307:Risk Factors; D011795:Surveys and Questionnaires; D016896:Treatment Outcome