Recent advances in intestinal macromolecular drug delivery via receptor-mediated transport pathways.
Receptor-mediated transport mechanisms provide a pathway for the trafficking of extracellular macromolecules into (endocytosis) and across (transcytosis) the cell. This comprises the binding of a ligand to a specific cell-surface receptor, clustering of the ligand-receptor complexes in endocytotic vesicles and vesicular sorting. This review focuses on recent advances in cellular and molecular biology pertaining to receptor-mediated endocytosis. A concise overview is presented of current and potential future applications of targeting to RME mechanisms to improve oral macromolecular drug delivery.
Swaan
P W
PW
Division of Pharmaceutics and Pharmaceutical Chemistry, The Ohio State University, Columbus 43210, USA. swaan.1@osu.edu
D000284:Administration, Oral; D000818:Animals; D001692:Biological Transport; D016503:Drug Delivery Systems; D004705:Endocytosis; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D008670:Metals / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism*; D014815:Vitamins / Q000378:metabolism
D008670:Metals; D011956:Receptors, Cell Surface; D014815:Vitamins