Inhibitory effect of 2,5-dimethylpyrazine on oxytocic agent-induced uterine hypercontraction of normal or pregnant female rats.
Intraperitoneal administration of 2,5-dimethylpyrazine (2,5-DMP) was found to inhibit oxytocin- and prostaglandin F2alpha-induced tetanic uterine contractions in normal or pregnant female rats. This suggests that 2,5-DMP may be used as a countercontraction agent or relaxant for preventing oxytocic agent-induced medical accident including uterine rupture or pressure death of the fetus due to uterine contractions.
Yamada
K
K
Tokyo University of Pharmacy and Life Science, Hachioji, Japan.
Kobayashi
Y
Y
Fujihara
H
H
Ohta
A
A
D000818:Animals; D015237:Dinoprost / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004576:Electromyography; D005260:Female; D007274:Injections, Intraperitoneal; D010120:Oxytocics / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D010121:Oxytocin / Q000037:antagonists & inhibitors / Q000494:pharmacology; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000502:physiology*; D011719:Pyrazines / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014590:Uterine Contraction / Q000187:drug effects*
D010120:Oxytocics; D011719:Pyrazines; D010121:Oxytocin; D015237:Dinoprost; C075524:2,5-dimethylpyrazine