title: Comparison of hypertonic saline-dextran solution and lactated Ringer's solution for resuscitating severely dehydrated calves with diarrhea.
abstract: OBJECTIVE
  To determine effectiveness of rapid i.v. administration of hypertonic saline-dextran (HSD) solution combined with oral administration of isotonic electrolyte solution for resuscitating severely dehydrated calves and to compare the resuscitative response with that of a conventional treatment of lactated Ringer's solution (LRS) i.v. and orally administered isotonic electrolyte solution.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  15 male dairy calves 3 to 10 days old.
  
  
  METHODS
  Baseline data were obtained. Osmotic diarrhea and severe dehydration were induced for 48 hours. Calves were then allocated to 3 treatment groups. The control group (group C) did not receive fluids, a second group (group H) received hypertonic saline (7.2% NaCl) solution with 6% dextran 70 and isotonic electrolyte solution, and a third group (group L) received LRS and isotonic electrolyte solution. Physical examinations were performed every 8 hours.
  
  
  RESULTS
  Calves developed diarrhea, lethargy, severe dehydration (mean, 14% of body weight), azotemia, hyperkalemia, and mild acidemia. Group-C calves remained lethargic and severely dehydrated during the 24-hour treatment phase. Calves treated with HSD and LRS were effectively resuscitated; however, response for most variables was more rapid and sustained for the HSD-treated group. Cardiac output was greater in LRS- than HSD-treated calves 1, 2, and 8 hours after initiation of treatment because of continued i.v. administration of fluids.
  
  
  CONCLUSIONS
  A combination of HSD and isotonic electrolyte solution was a rapid and effective method for resuscitation of severely dehydrated calves. It was similar in effectiveness to conventional treatment in which LRS and isotonic electrolyte solution were used for resuscitating calves with severe dehydration.
authors.affiliation: Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana 61802, USA.
authors.forename: P G
authors.initials: PG
authors.lastname: Walker
authors.forename: P D
authors.initials: PD
authors.lastname: Constable
authors.forename: D E
authors.initials: DE
authors.lastname: Morin
authors.forename: J H
authors.initials: JH
authors.lastname: Foreman
authors.forename: J K
authors.initials: JK
authors.lastname: Drackley
authors.forename: J C
authors.initials: JC
authors.lastname: Thurmon
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000831:Animals, Newborn; D002302:Cardiac Output; D002417:Cattle; D002418:Cattle Diseases / Q000503:physiopathology / Q000628:therapy*; D003681:Dehydration / Q000209:etiology / Q000503:physiopathology / Q000628:therapy / Q000662:veterinary*; D003911:Dextrans / Q000008:administration & dosage; D003967:Diarrhea / Q000150:complications / Q000503:physiopathology / Q000662:veterinary*; D004573:Electrolytes / Q000008:administration & dosage; D005440:Fluid Therapy / Q000662:veterinary*; D007262:Infusions, Intravenous / Q000662:veterinary; D007552:Isotonic Solutions / Q000008:administration & dosage; D008297:Male; D010953:Plasma Volume; D011446:Prospective Studies; D011897:Random Allocation; D015532:Rehydration Solutions / Q000008:administration & dosage; D000077325:Ringer's Lactate; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage; D013318:Stroke Volume; D014554:Urination
chemical_list: D003911:Dextrans; D004573:Electrolytes; D007552:Isotonic Solutions; D015532:Rehydration Solutions; D000077325:Ringer's Lactate; D012462:Saline Solution, Hypertonic