title: CT findings in neonatal hypothermia.
abstract: BACKGROUND
  Newborn infants are particularly prone to hypothermia, a condition with a high mortality.
  
  
  OBJECTIVE
  To study the CT brain patterns in infants with hypothermia and neurological symptoms.
  
  
  METHODS
  We reviewed the brain CT of nine infants with neonatal hypothermia, multiple organ failure, seizures and coma.
  
  
  RESULTS
  Two infants had normal CT scans, acutely and at follow-up, and were clinically normal at follow-up. In seven infants, CT showed diffuse cerebral oedema, with reversal of the normal density relationship between grey and white matter and a relative increased density of the thalami, brainstem and cerebellum - the 'reversal sign'. In six surviving infants with severe developmental delay, follow-up CT revealed cerebral atrophy with multicystic encephalomalacia.
  
  
  CONCLUSIONS
  The 'reversal sign' has been described in the abused child, birth asphyxia and anoxia due to drowning. Neonatal hypothermia is offered as a further cause.
authors.affiliation: Department of Radiology, Soroka Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, P. O. Box 151, Beer-Sheva 84101, Israel.
authors.forename: H
authors.initials: H
authors.lastname: Schulman
authors.forename: L
authors.initials: L
authors.lastname: Laufer
authors.forename: J
authors.initials: J
authors.lastname: Berginer
authors.forename: E
authors.initials: E
authors.lastname: Hershkowitz
authors.forename: T
authors.initials: T
authors.lastname: Berenstein
authors.forename: S
authors.initials: S
authors.lastname: Sofer
authors.forename: E
authors.initials: E
authors.lastname: Maor
authors.forename: Y
authors.initials: Y
authors.lastname: Hertzanu
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging*; D001925:Brain Damage, Chronic / Q000209:etiology; D001929:Brain Edema / Q000000981:diagnostic imaging / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007035:Hypothermia / Q000150:complications / Q000000981:diagnostic imaging*; D007231:Infant, Newborn; D008297:Male; D013997:Time Factors; D014057:Tomography, X-Ray Computed