[Purinoceptor-induced cytoplasmic calcium oscillation in megakaryocytes].
Megakaryocytes isolated from rat bone marrow respond to externally applied ATP and ADP, showing a periodic K+ current that reflects oscillation in cytoplasmic calcium concentration. The agonist selectivity of the purinoceptor on the megakaryocyte is unique. In addition, the intracellular mechanism of calcium oscillation and the effects of many modulating factors were investigated.
Uneyama
C
C
uneyama@nihs.go.jp
D000244:Adenosine Diphosphate / Q000502:physiology; D000255:Adenosine Triphosphate / Q000502:physiology; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D008533:Megakaryocytes / Q000378:metabolism*; D015221:Potassium Channels / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D011983:Receptors, Purinergic / Q000502:physiology*
D015221:Potassium Channels; D011983:Receptors, Purinergic; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D002118:Calcium