title: A2rel: a constitutively expressed Leishmania gene linked to an amastigote-stage-specific gene.
abstract: The A2-A2rel gene copies are arranged in tandem arrays on a 850 kb chromosome in Leishmania donovani. Contrary to A2 mRNA which displays amastigote-stage-specific expression, A2rel gene expression is constitutive throughout the L. donovani life cycle. The A2rel sequence was found to be conserved in all Leishmania species tested, while the A2 sequence is specific to L. donovani and L. mexicana. The A2rel full length cDNA is of 2.3 kb and it contains one open reading frame coding for a putative protein of 436 amino acids.
authors.affiliation: Institute of Parasitology, McGill University, Macdonald campus, Ste Anne-de-Bellevue, Quebec, Canada.
authors.forename: E
authors.initials: E
authors.lastname: Ghedin
authors.forename: H
authors.initials: H
authors.lastname: Charest
authors.forename: G
authors.initials: G
authors.lastname: Matlashewski
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000953:Antigens, Protozoan; D001483:Base Sequence; D002454:Cell Differentiation; D002874:Chromosome Mapping; D017124:Conserved Sequence; D018628:Gene Dosage; D015870:Gene Expression; D008040:Genetic Linkage; D007893:Leishmania donovani / Q000166:cytology / Q000235:genetics*; D008969:Molecular Sequence Data; D005810:Multigene Family; D015800:Protozoan Proteins / Q000235:genetics*
chemical_list: C107645:A2 protein, Leishmania donovani; C114748:A2rel protein, Lesimania; D000953:Antigens, Protozoan; D015800:Protozoan Proteins