title: Application of FT-IR microspectroscopy to the study of an injectable composite for bone and dental surgery.
abstract: Hydroxypropylmethylcellulose (HPMC) of high-viscosity grade is used as a ligand for a bioactive calcium phosphate ceramic (the filler) in a ready-to-use injectable sterilized biomaterial for bone and dental surgery. Application of physico-chemical methods such as XPS, NMR, or Raman spectroscopy encounters difficulties when used to study such a multiphased material. This paper reports on the application of FT-IR microspectroscopy (FT-IRM) for the investigation of inorganic and organic phases of the rough composite and separated phases obtained by mechanical or chemical extraction methods. A comparison of FT-IRM with the conventional KBr pellet method was made and indicates that the macro and micro FT-IR methods are complementary: the former revealed new chemical groups not visualized with the KBr method whereas the latter detected the major compound of the blend. FT-IR microspectroscopy was revealed to be a powerful method of analysis that is complementary to other existing spectroscopic methods. Moreover, it is expected to be a useful tool in the study of biomaterials in biological samples.
authors.affiliation: Centre de Recherche sur les Matériaux d'Intérêt Biologique, UPRES EA 2159, Faculté de Chirurgie Dentaire, Nantes, France.
authors.forename: P
authors.initials: P
authors.lastname: Weiss
authors.forename: S
authors.initials: S
authors.lastname: Bohic
authors.forename: M
authors.initials: M
authors.lastname: Lapkowski
authors.forename: G
authors.initials: G
authors.lastname: Daculsi
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D001843:Bone Cements / Q000737:chemistry*; D003188:Composite Resins / Q000737:chemistry*; D003764:Dental Materials / Q000737:chemistry*; D065347:Hypromellose Derivatives; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods*; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D001843:Bone Cements; D003188:Composite Resins; D003764:Dental Materials; D065347:Hypromellose Derivatives; D008747:Methylcellulose