[Relation between fetal intrauterine growth retardation and anticardiolipin antibodies].
OBJECTIVE
To investigate the relationship between fetal intrauterine growth retardation and anticardiolipin antibodies.


METHODS
Serum anticardiolipin antibodies were detected with ELISA method in 5,330 cases of normal gravidas. Meanwhile, the observation of immunocomplex depositions in placentas in cases of positive anticardiolipin antibodies (ACA) were observed by immunofluorescence examination.


RESULTS
The positive ACA rate in normal gravidas was 2.70%. The incidence of intrauterine growth retardation (IUGR) was 15.28% in cases of positive ACA, whereas was 1.77% in cases of negative ACA. There were significant differences between two groups (P < 0.001). Among children born in mothers with positive ACA, there were 5 cases of positive ACA. Immunocomplex depositions (Immunoglobulins & Complements) were all found in placenta of IUGR.


CONCLUSIONS
ACA could be one of causes of IUGR. Determination of serum ACA would offer a new clue to diagnosis and treatment of IUGR.
Wang
Z
Z
Chang Zhou Obstetric and Gynecologic Hospital, Changzhou.
Fan
Y
Y
Wu
G
G
D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood*; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis; D005317:Fetal Growth Retardation / Q000175:diagnosis / Q000276:immunology*; D006801:Humans; D007231:Infant, Newborn; D010920:Placenta / Q000648:ultrastructure; D011247:Pregnancy; D011296:Prenatal Diagnosis
D017153:Antibodies, Anticardiolipin