title: Two new ergostane-type steroidal lactones from Withania coagulans.
abstract: Two new withanolides (steroidal lactones) named coagulin F [27-hydroxy-14,20-epoxy-1-oxo-(22R)-witha-3,5,24-trienolide] (1) and coagulin G [17beta,27-dihydroxy-14,20-epoxy-1-oxo-(22R)-witha-2,5, 24-trienolide] (2) were isolated from the whole plant of Withania coagulans, and their structures were deduced by spectral analysis.
authors.affiliation: International Center for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.
authors.forename: A
authors.initials: A
authors.lastname: Atta-ur-Rahman
authors.forename: M I
authors.initials: MI
authors.lastname: Choudhary
authors.forename: S
authors.initials: S
authors.lastname: Qureshi
authors.forename: W
authors.initials: W
authors.lastname: Gul
authors.forename: M
authors.initials: M
authors.lastname: Yousaf
mesh_terms: D000107:Acetylation; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D004875:Ergosterol / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D007783:Lactones / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010154:Pakistan; D010946:Plants, Medicinal / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000935:Antifungal Agents; D007783:Lactones; C113223:coagulin F; C113224:coagulin G; D004875:Ergosterol