title: Basic studies on N''-ursodeoxycholyldiethylenetriamine-N,N,N'-triacetic acid for the dissolution of calcified gallstones.
abstract: A novel calcium-chelating agent, N"-ursodeoxycholyldiethylenetriamine-N,N,N'-triacetic acid (UDCA-DTTA), was synthesized to study its ability to dissolve calcified gallstones. The chelating activity of the compound was demonstrated by dissolving calcium carbonate in vitro at a high dissolution rate. In the presence of the agent, sliced human gallstone with a composition of more than 50% calcium bilirubinate was thoroughly dissolved, indicating that calcium bilirubinate was dissolved from the gallstone. The ability to dissolve calcium was comparable to that of EDTA. However, the laminar structure of the sliced gallstone did not disappear in the presence of EDTA, whereas the structure disappeared in the presence of UDCA-DTTA. All these results indicate that UDCA-DTTA is an interesting compound as a parent substance for developing a prodrug for an oral or intravenous agent to dissolve calcium-containing gallstones.
authors.affiliation: Department of Surgery, Chugoku Rosai Hospital, Hiroshima, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Konishi
authors.forename: Y
authors.initials: Y
authors.lastname: Maeda
authors.forename: M
authors.initials: M
authors.lastname: Fukuzawa
authors.forename: T
authors.initials: T
authors.lastname: Nishida
authors.forename: T
authors.initials: T
authors.lastname: Ohya
authors.forename: K
authors.initials: K
authors.lastname: Katayama
authors.forename: N
authors.initials: N
authors.lastname: Kakehi
authors.forename: H
authors.initials: H
authors.lastname: Sakakura
authors.forename: A
authors.initials: A
authors.lastname: Takagi
authors.forename: M
authors.initials: M
authors.lastname: Maeda
authors.forename: H
authors.initials: H
authors.lastname: Ohama
mesh_terms: D000284:Administration, Oral; D000581:Amidohydrolases / Q000378:metabolism; D000818:Animals; D001646:Bile / Q000737:chemistry; D001663:Bilirubin / Q000737:chemistry; D002118:Calcium; D002119:Calcium Carbonate / Q000737:chemistry; D002614:Chelating Agents / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D002769:Cholelithiasis / Q000737:chemistry*; D004355:Drug Stability; D004492:Edetic Acid / Q000737:chemistry; D006801:Humans; D007275:Injections, Intravenous; D007413:Intestinal Mucosa / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008297:Male; D010179:Pancreas / Q000201:enzymology; D010194:Pancreatin / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014580:Ursodeoxycholic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism
chemical_list: D002614:Chelating Agents; C113997:N''-ursodeoxycholyldiethylene-N,N,N'-triacetic acid; D014580:Ursodeoxycholic Acid; D010194:Pancreatin; D004492:Edetic Acid; D000581:Amidohydrolases; C023154:choloylglycine hydrolase; D002119:Calcium Carbonate; D001663:Bilirubin; D002118:Calcium