Morphometric and ultrastructural studies of the spinal sensory ganglia in the course of sciatic nerve regeneration in rats intoxicated with ethanol.
The aim of the study was to examine morphological changes in the spinal dorsal ganglia (from which sensory fibres of the sciatic nerve extend) in animals intoxicated with ethanol, in which the sciatic nerve was transected and then sutured. By means of morphometric methods using a computer system of picture analysis and in ultrastructural examinations it was found that ethanol administered to rats to drink for 3 months caused only slight morphological alterations in the sensory nerve cells of the spinal vertebral ganglia on the non-operated side. However, ethanol or its metabolites destroyed the regenerating sensory nerve cells of the spinal vertebral ganglia of the transected and then sutured sciatic nerve.
Zimnoch
L
L
Department of Pathological Anatomy, Medical Academy of Białystok.
Kozielec
Z
Z
Szynaka
B
B
Dziecioł
J
J
Baltaziak
M
M
D000435:Alcoholic Intoxication / Q000473:pathology* / Q000503:physiopathology; D000818:Animals; D005727:Ganglia, Spinal / Q000648:ultrastructure*; D008854:Microscopy, Electron; D009416:Nerve Regeneration; D051381:Rats; D012584:Sciatic Nerve / Q000502:physiology*