The probability of in vivo reactivation of herpes simplex virus type 1 increases with the number of latently infected neurons in the ganglia.
The purpose of this study was to define the relationship between herpes simplex virus (HSV) latency and in vivo ganglionic reactivation. Groups of mice with numbers of latently infected neurons ranging from 1.9 to 24% were generated by varying the input titer of wild-type HSV type 1 strain 17syn+. Reactivation of the virus in mice from each group was induced by hyperthermic stress. The number of animals that exhibited virus reactivation was positively correlated with the number of latently infected neurons in the ganglia over the entire range examined (r = 0.9852, P < 0. 0001 [Pearson correlation]).
Sawtell
N M
NM
Division of Infectious Diseases, Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA. Sawtn0@CHMCC.org
D000212:Acyclovir / Q000008:administration & dosage; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage; D004195:Disease Models, Animal; D006561:Herpes Simplex / Q000188:drug therapy / Q000821:virology*; D018259:Herpesvirus 1, Human / Q000254:growth & development* / Q000502:physiology*; D006801:Humans; D008297:Male; D051379:Mice; D009474:Neurons / Q000821:virology*; D012668:Trigeminal Ganglion / Q000821:virology; D014775:Virus Activation; D017735:Virus Latency
D000998:Antiviral Agents; D000212:Acyclovir