[Micromycetes extracellular proteinases with fibrinolytic and anticoagulant properties].
One hundred and sixteen strains of microscopic fungal belonging to different taxonomic groups were tested for their ability ti synthesize extracellular proteinases with caseinolytic, fibrinolytic, plasminogen activator-like, and anticoagulant (prolonging the partial thromboplastin time) activities. Several producers of anticoagulants prolonging the partial thromboplastin time, probably via the activation of the protein C system, were revealed. The effectiveness of the fungal anticoagulants was close to that of the protein C activators from Agkistrodon snake venom.
Landau
N S
NS
Moscow State University, Vorob'evy gory, Russia.
Kurakov
A V
AV
Gulikova
O M
OM
Batomunkueva
B
B
Strukova
S M
SM
Egorov
N S
NS
D000925:Anticoagulants / Q000378:metabolism*; D002364:Caseins / Q000378:metabolism; D010450:Endopeptidases / Q000096:biosynthesis / Q000378:metabolism*; D005343:Fibrinolytic Agents / Q000378:metabolism*; D005658:Fungi / Q000145:classification / Q000201:enzymology*; D006868:Hydrolysis; D010960:Plasminogen Activators / Q000378:metabolism; D013045:Species Specificity
D000925:Anticoagulants; D002364:Caseins; D005343:Fibrinolytic Agents; D010450:Endopeptidases; D010960:Plasminogen Activators
Ekstratselliularnye proteinazy mikromitsetov s fibrinoliticheskimi i antikoaguliantnymi svoĭstvami.