Long-lived plasma cells: a mechanism for maintaining persistent antibody production.
Current models suggest that continuous antigenic stimulation of memory B cells is required to maintain long-term antibody production. In view of recent developments concerning plasma cell longevity, a new model is described that incorporates the important role of long-lived plasma cells in sustaining persistent antibody responses.
Slifka
M K
MK
Scripps Research Institute, Department of Neuropharmacology, La Jolla, CA 92122, USA.
Ahmed
R
R
D000818:Animals; D000917:Antibody Formation; D000936:Antigen-Antibody Complex / Q000276:immunology; D016175:B-Lymphocyte Subsets / Q000276:immunology; D002465:Cell Movement; D016922:Cellular Senescence; D002908:Chronic Disease; D003429:Cross Reactions; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000276:immunology; D007156:Immunologic Memory / Q000276:immunology*; D008213:Lymphocyte Activation; D051379:Mice; D018448:Models, Immunological; D010950:Plasma Cells / Q000166:cytology* / Q000276:immunology; D014611:Vaccination
D000936:Antigen-Antibody Complex; D007130:Immunoglobulin Idiotypes