title: Novel thiazolidinedione derivatives with retinoid synergistic activity.
abstract: Several arylmethylidene thiazolidinediones were synthesized and their retinoidal activities were examined. TZ181 (7a), having a benzanilide skeleton, exhibited differentiation-inducing activity in HL-60 cell assay, while TZ191 (7b), the N-methylated analog of TZ181 (7a), TZ245 (9) and TZ335 (10) acted as retinoid synergists like the RXR-selective ligand, LGD1069 (5).
authors.affiliation: Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ebisawa
authors.forename: E
authors.initials: E
authors.lastname: Kawachi
authors.forename: H
authors.initials: H
authors.lastname: Fukasawa
authors.forename: Y
authors.initials: Y
authors.lastname: Hashimoto
authors.forename: A
authors.initials: A
authors.lastname: Itai
authors.forename: K
authors.initials: K
authors.lastname: Shudo
authors.forename: H
authors.initials: H
authors.lastname: Kagechika
mesh_terms: D002454:Cell Differentiation / Q000187:drug effects; D004357:Drug Synergism; D018922:HL-60 Cells; D006801:Humans; D012176:Retinoids / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000494:pharmacology*
chemical_list: D012176:Retinoids; D013844:Thiazoles