Cytogenetic analysis of hepatoblastoma: hypothesis of cytogenetic evolution in such tumors and results of a multicentric study.
Hepatoblastoma is a rare pediatric malignant tumor of the liver. Previous cytogenetic reports are sporadic. We karyotyped nine consecutive hepatoblastomas from the Italian centers participating in a multicentric study on hepatic tumors (SIOPEL 1). Six cases showed abnormal karyotypes. The most common abnormalities were trisomies of chromosomes 2 and 20. Four cases showed abnormalities of chromosome 1. On the basis of findings, we speculate the possibility of a cytogenetic evolutive pattern of hepatoblastomas.
Sainati
L
L
Dipartimento di Pediatria, Università di Padova, Italy.
Leszl
A
A
Stella
M
M
Montaldi
A
A
Perilongo
G
G
Rugge
M
M
Bolcato
S
S
Iolascon
A
A
Basso
G
G
D002675:Child, Preschool; D002999:Clone Cells / Q000473:pathology; D005260:Female; D018197:Hepatoblastoma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D007621:Karyotyping; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000235:genetics / Q000473:pathology; D014407:Tumor Cells, Cultured