title: Medical illness burden, trait neuroticism, and depression in older primary care patients.
abstract: OBJECTIVE
  The authors tested the hypotheses that medical illness burden is independently associated with depression and that this association is moderated by neuroticism.
  
  
  METHODS
  Multiple regression techniques were used to determine the independent associations of medical burden and neuroticism with depression in a group of 196 subjects, 60 years of age and older, recruited from primary care settings.
  
  
  RESULTS
  Medical burden and neuroticism were independently associated with major depression, depressive symptoms, and psychiatric dysfunction.
  
  
  CONCLUSIONS
  These findings support models in which medical disorders may contribute directly to depression. At the same time, the role of neuroticism in later-life depression warrants further study.
authors.affiliation: Department of Psychiatry, University of Rochester School of Medicine and Dentistry, NY, USA. Jeffrey_Lyness@urmc.rochester.edu
authors.forename: J M
authors.initials: JM
authors.lastname: Lyness
authors.forename: P R
authors.initials: PR
authors.lastname: Duberstein
authors.forename: D A
authors.initials: DA
authors.lastname: King
authors.forename: C
authors.initials: C
authors.lastname: Cox
authors.forename: E D
authors.initials: ED
authors.lastname: Caine
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015897:Comorbidity; D003866:Depressive Disorder / Q000175:diagnosis* / Q000453:epidemiology; D015577:Geriatric Assessment; D006304:Health Status; D006801:Humans; D001523:Mental Disorders / Q000175:diagnosis; D008875:Middle Aged; D009497:Neurotic Disorders / Q000175:diagnosis* / Q000453:epidemiology; D010551:Personality / Q000145:classification*; D010555:Personality Inventory / Q000706:statistics & numerical data; D011320:Primary Health Care; D011569:Psychiatric Status Rating Scales; D012044:Regression Analysis