Gene cloning of BM180, a lacrimal gland enriched basement membrane protein with a role in stimulated secretion.
BM180 is a novel basement membrane component with a role in regulated tear secretion by lacrimal acinar cells. BM180 bears some sequence similarity to alpha-gliadin, a plant protein against which antibodies have been reported in patients with Sjögren's syndrome. A precedent for plantlike sequence in the mammalian genome is provided by selectins, which possess a plant lectinlike domain involved in inflammatory cell homing. Cloning the mouse and human BM180 gene will aid molecular investigation of lacrimal acinar cell-BM180 interactions and may lead to a new molecular understanding of mechanisms contributing to dry eye.
Asrani
A C
AC
Department of Cell Biology, University of Virginia, Charlottesville, USA.
Lumsden
A J
AJ
Kumar
R
R
Laurie
G W
GW
D000818:Animals; D000906:Antibodies / Q000097:blood; D001485:Basement Membrane / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000096:biosynthesis* / Q000737:chemistry / Q000378:metabolism; D003001:Cloning, Molecular; D005136:Eye Proteins / Q000378:metabolism*; D005903:Gliadin / Q000737:chemistry / Q000276:immunology; D006801:Humans; D007765:Lacrimal Apparatus / Q000378:metabolism*; D008322:Mammals; D051379:Mice; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism; D012859:Sjogren's Syndrome / Q000276:immunology; D013666:Tears / Q000502:physiology; D014908:Triticum / Q000378:metabolism
D000906:Antibodies; C101023:BM180 protein, mouse; D015815:Cell Adhesion Molecules; D005136:Eye Proteins; D011994:Recombinant Proteins; C042434:tear proteins; D005903:Gliadin