Effects of IFN-beta on human cerebral blood flow distribution.
The effect of interferon-beta1b (IFN-beta) on human cerebral blood flow distribution was examined in five multiple sclerosis patients using functional brain single-photon emission tomography (SPECT). Of nine regions of interest studied, only the basal ganglia exhibited a significant change (increase) in relative photon emission intensity (i.e., relative blood flow) when comparing SPECT scans obtained 6 h after s.c. IFN-beta injection with scans obtained at the same time of day (noon) 30 h after IFN-beta injection (IFN-beta-free day). The increase in relative blood flow to the basal ganglia following IFN-beta injection correlated positively with changes in mean arterial pressure (MAP). Additional studies will be required to determine the relevance of these observations for IFN-beta-induced central nervous system side effects.
Mackowiak
P A
PA
Medical Care Clinical Center, Imaging Service, VA Maryland Health Care System, Baltimore, USA.
Siegel
E
E
Wasserman
S S
SS
Cameron
E
E
Nessaiver
M S
MS
Bever
C T
CT
D000328:Adult; D001479:Basal Ganglia / Q000000981:diagnostic imaging / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D001921:Brain / Q000000981:diagnostic imaging / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects; D002540:Cerebral Cortex / Q000098:blood supply / Q000187:drug effects*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005260:Female; D006801:Humans; D016899:Interferon-beta / Q000494:pharmacology*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology; D015899:Tomography, Emission-Computed, Single-Photon
D016899:Interferon-beta