Transcriptional cooperativity: bending over backwards and doing the flip.
The structures of the NFAT1-Fos-Jun-ARRE2 and MAT alpha 2-MCM1-STE6 transcription regulatory complexes reveal changes in protein conformation and DNA bending. Studies of the interaction between Fos-Jun and NFAT1 in solution corroborate the crystallographic analysis. These results manifest the flexibility required for cooperative binding to composite regulatory elements.
Kerppola
T K
TK
Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor 48109-0650, USA. kerppola@umich.edu
D004247:DNA; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D005786:Gene Expression Regulation; D008958:Models, Molecular; D008968:Molecular Conformation; D009690:Nucleic Acid Conformation; D011485:Protein Binding; D011487:Protein Conformation; D014157:Transcription Factors / Q000737:chemistry / Q000378:metabolism*; D014158:Transcription, Genetic
D004268:DNA-Binding Proteins; D014157:Transcription Factors; D004247:DNA