Effects of ligustrazine on bone marrow microvessel system in the early period of acute radiation injury in mice.
Sublethally irradiated mice were immediately treated with 250 mg/kg Ligustrazine Phosphiatis intraperitoneally twice a day for seven days, and the bone marrow microvessels of the Ligustrazine group was much greater than that of the control group. On the 7th day, the amount of the control group decreased to normal, while the ligustrazine group was still increasing, and the microvessel area was enlarged obviously.. The percentage of the hematopoietic tissue volume in bone marrow between the two groups had no significant difference in the first 7 days. On the 7th day after irradiation, the peripheral neutrophilic granulocytes increased in the Ligustrazine group. The results suggested that early use of Ligustrazine after acute radiation injury might improve the blood supply of bone marrow, and be helpful for recovery of hematopoiesis.
Xiao
K
K
Department of Hematology, Tongji Hospital, Tongji Medical University, Wuhan.
Liu
W
W
Lu
W
W
Xu
H
H
Sun
H
H
Tang
J
J
D000818:Animals; D001853:Bone Marrow / Q000098:blood supply*; D003037:Cobalt Radioisotopes; D006413:Hematopoietic System / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D051379:Mice; D008833:Microcirculation / Q000187:drug effects; D011719:Pyrazines / Q000494:pharmacology*; D011833:Radiation Injuries, Experimental / Q000503:physiopathology*; D011837:Radiation-Protective Agents / Q000494:pharmacology*
D003037:Cobalt Radioisotopes; D011719:Pyrazines; D011837:Radiation-Protective Agents; C017953:tetramethylpyrazine