title: Synthesis and antibacterial activities of new carbapenems having a proline reverse amide moiety at the C-2 position.
abstract: The synthesis of new 1 beta-methylcarbapenems (1a-l) having a proline reverse amide moiety at the C-2 position and their in vitro antibacterial activities are described. The compounds were evaluated by the Mueller-Hinton agar dilution method and compared with meropenem as control. Aliphatic amides (1a-h) are found to show greater antibacterial activity than aromatic amides (1i-l). Moreover, C-2 free amino compound (1m) reveals greater activity than any other amide compounds (1a-l).
authors.affiliation: Medicinal Chemistry Research Center, Korea Institute of Science and Technology, Seoul, Korea.
authors.forename: S H
authors.initials: SH
authors.lastname: Hwang
authors.forename: K J
authors.initials: KJ
authors.lastname: Shin
authors.forename: Y K
authors.initials: YK
authors.lastname: Kang
authors.forename: D J
authors.initials: DJ
authors.lastname: Kim
authors.forename: D C
authors.initials: DC
authors.lastname: Kim
authors.forename: K H
authors.initials: KH
authors.lastname: Yoo
authors.forename: S W
authors.initials: SW
authors.lastname: Park
authors.forename: K J
authors.initials: KJ
authors.lastname: Lee
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry; D015780:Carbapenems / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D011392:Proline / Q000031:analogs & derivatives / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D015780:Carbapenems; D011392:Proline