title: Premature ejaculation and serotonergic antidepressants-induced delayed ejaculation: the involvement of the serotonergic system.
abstract: Premature ejaculation has generally been considered a psychosexual disorder with psychogenic aetiology. Although still mainly treated by behavioural therapy, in recent years double-blind studies have indicated the beneficial effects of some of the serotonergic antidepressants (SSRIs) in delaying ejaculation. We describe here the neurophysiology and the peripheral neuroanatomy of ejaculation and provide a review of the involvement of serotonin in the central nervous system in relation to serotonergic nuclei and their projections. A hypothesis of the role of 5-HT1A and 5-HT2C receptors in premature ejaculation is postulated.
authors.affiliation: Department of Psychiatry and Neurosexology, Leyenburg Hospital, The Hague, The Netherlands.
authors.forename: M D
authors.initials: MD
authors.lastname: Waldinger
authors.forename: H H
authors.initials: HH
authors.lastname: Berendsen
authors.forename: B F
authors.initials: BF
authors.lastname: Blok
authors.forename: B
authors.initials: B
authors.lastname: Olivier
authors.forename: G
authors.initials: G
authors.lastname: Holstege
mesh_terms: D000818:Animals; D004542:Ejaculation / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008297:Male; D012701:Serotonin / Q000502:physiology*; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*
chemical_list: D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors