title: Effects of transjugular intrahepatic portosystemic shunt (TIPS) on esophageal motor function and gastroesophageal reflux.
abstract: The effects of transjugular intrahepatic portosystemic shunt (TIPS) placement on esophageal motor function and gastroesophageal reflux were investigated in patients with esophageal varices. In six men with esophageal varices, esophageal manometry and upper gastrointestinal endoscopy were performed before and 15-20 days after TIPS placement. Intraesophageal pH monitoring was performed in the four patients with severe esophageal varices (defined as the largest sized varices) following TIPS placement. Findings were compared with those in six healthy men (controls) who underwent esophageal manometry and intraesophageal pH monitoring. The esophageal varices resolved or were reduced after TIPS placement. Resting lower esophageal sphincter (LES) pressures were similar in the study group before and after TIPS placement and in the control subjects. The incidence and progression of esophageal contractions were similar in the study group before and after TIPS placement and in the control subjects. At 3 cm above the LES, the amplitude of esophageal contraction after TIPS placement was significantly higher than that before TIPS placement. At 3 and 8 cm above the LES, the amplitude of esophageal contraction in the control subjects was significantly higher than that in the study group before and after TIPS placement. Esophageal acid exposure time after TIPS placement was similar to that in the controls. TIPS placement is a useful treatment that improves esophageal motor function without the occurrence of pathologic gastroesophageal reflux.
authors.affiliation: Third Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Iwakiri
authors.forename: H
authors.initials: H
authors.lastname: Kanazawa
authors.forename: S
authors.initials: S
authors.lastname: Matsuzaka
authors.forename: N
authors.initials: N
authors.lastname: Tada
authors.forename: H
authors.initials: H
authors.lastname: Saitoh
authors.forename: H
authors.initials: H
authors.lastname: Yoshimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Nakagawa
authors.forename: Y
authors.initials: Y
authors.lastname: Osada
authors.forename: T
authors.initials: T
authors.lastname: Sugiura
authors.forename: M
authors.initials: M
authors.lastname: Kotoyori
authors.forename: Y
authors.initials: Y
authors.lastname: Mamiya
authors.forename: H
authors.initials: H
authors.lastname: Yamada
authors.forename: Y
authors.initials: Y
authors.lastname: Narahara
authors.forename: A
authors.initials: A
authors.lastname: Kawakami
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
mesh_terms: D004932:Esophageal and Gastric Varices / Q000503:physiopathology / Q000628:therapy*; D004945:Esophagoscopy; D004947:Esophagus / Q000503:physiopathology*; D005764:Gastroesophageal Reflux / Q000517:prevention & control*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D019168:Portasystemic Shunt, Transjugular Intrahepatic / Q000379:methods