title: Aortic reconstruction with crimped bovine pericardial conduits.
abstract: OBJECTIVE
  A bovine pericardial conduit processed in glutaraldehyde was designed, incorporating the principle of crimping used for synthetic vascular prostheses. The crimping process did not affect the integrity of collagen fibers and tissue structure. This conduit, designed for aortic reconstruction, is available in different sizes, with or without a biological valve.
  
  
  METHODS
  Between October 1989 and May 1997, 40 patients with aortic dissection, aortic aneurysm, aortic coarctation or aortoiliac occlusive disease underwent aortic reconstruction using this vascular substitute. Procedures included total reconstruction of the ascending aorta and aortic valve with reimplantation of coronary arteries (nine patients), single ascending thoracic aorta (six), descending thoracic aorta (two), aortic arch (one) and thoracoabdominal aorta (one); the abdominal aorta was reconstructed in 21 cases, including those undergoing aortoiliac or aortofemoral bypass.
  
  
  RESULTS
  The hospital mortality rate was 20% (eight patients); causes of deaths were low cardiac output, recurrence of aortic dissection, multiple organ failure and bleeding. Mean follow up was 3.6 years; total follow up was 114 patient-years. Late conduit-related complications occurred in four patients, including a limb obstruction in one patient subjected to aortofemoral bypass and infection of three resulting in pseudoaneurysm (incidence of 3.5 +/- 1.8% per patient-year). All underwent reoperation. There were four late deaths due to sudden death, coronary artery disease, pneumonia and metabolic complications of diabetes and renal failure (incidence of 3.5 +/- 1.8% per patient year). The eight-year actuarial survival rate was 63.7 +/- 11.6%, including hospital mortality, and the eight-year actuarial freedom from conduit failure due to primary tissue structural degeneration was 100%.
  
  
  CONCLUSIONS
  The crimping design provides a circular tube which makes construction of the anastomosis easier, retains its shape with bending, and avoids kinking. The material is very soft, easy to handle and suture, coapts nicely to suture lines resulting in a hemostatic anastomosis. The eight-year follow up demonstrated a satisfactory performance without report of fibrosis, calcification or aneurysmal dilation.
authors.affiliation: Hospital Felicio Rocho, Belo Horizonte, M.G., Brazil.
authors.forename: C A
authors.initials: CA
authors.lastname: Salles
authors.forename: M C
authors.initials: MC
authors.lastname: Moreira
authors.forename: P M
authors.initials: PM
authors.lastname: Borem
authors.forename: J B
authors.initials: JB
authors.lastname: Gusmăo
authors.forename: V C
authors.initials: VC
authors.lastname: Teixeira
authors.forename: R R
authors.initials: RR
authors.lastname: Silva
authors.forename: H F
authors.initials: HF
authors.lastname: Prates
authors.forename: E S
authors.initials: ES
authors.lastname: Araujo
authors.forename: C L
authors.initials: CL
authors.lastname: Gelape
authors.forename: S R
authors.initials: SR
authors.lastname: Silva
mesh_terms: D000818:Animals; D001012:Aorta, Abdominal / Q000601:surgery; D001013:Aorta, Thoracic / Q000601:surgery; D001018:Aortic Diseases / Q000401:mortality / Q000601:surgery*; D001021:Aortic Valve / Q000601:surgery; D001705:Bioprosthesis / Q000009:adverse effects / Q000706:statistics & numerical data; D001807:Blood Vessel Prosthesis / Q000009:adverse effects / Q000706:statistics & numerical data; D019917:Blood Vessel Prosthesis Implantation / Q000379:methods / Q000401:mortality; D002417:Cattle; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010496:Pericardium / Q000637:transplantation; D011474:Prosthesis Design; D015996:Survival Rate; D013997:Time Factors