title: Studies on the constituents of Broussonetia species. III. Two new pyrrolidine alkaloids, broussonetines G and H, as inhibitors of glycosidase, from Broussonetia kazinoki Sieb.
abstract: Two new pyrrolidine alkaloids, broussonetines G and H, were isolated from the branches of Broussonetia kazinoki SIEB. (Moraceae). Broussonetines G and H were formulated as 2 beta-hydroxymethyl-3 alpha, 4 beta-dihydroxy-5 alpha-(1-hydroxy- 6:10;10:13-diepoxytridecyl)-pyrrolidine (1) and 2 beta-hydroxymethyl-3 alpha, 4 beta-dihydroxy-5 alpha-(1-hydroxy- 5:9;9:13-diepoxytridecyl)-pyrrolidine (2), respectively, by spectroscopic methods. 1 and 2 inhibited beta-glucosidase, beta-galactosidase and beta-mannosidase.
authors.affiliation: Osaka University of Pharmaceutical Sciences, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Shibano
authors.forename: S
authors.initials: S
authors.lastname: Nakamura
authors.forename: N
authors.initials: N
authors.lastname: Akazawa
authors.forename: G
authors.initials: G
authors.lastname: Kusano
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008361:Mannosidases / Q000037:antagonists & inhibitors*; D013058:Mass Spectrometry; D010946:Plants, Medicinal / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001616:beta-Galactosidase / Q000037:antagonists & inhibitors*; D001617:beta-Glucosidase / Q000037:antagonists & inhibitors*; D044902:beta-Mannosidase
chemical_list: D000470:Alkaloids; D011759:Pyrrolidines; C113406:broussonetine G; C113405:broussonetine H; D008361:Mannosidases; D001617:beta-Glucosidase; D001616:beta-Galactosidase; D044902:beta-Mannosidase