title: [Chlormadinone Acetate Reference Standard (Control 961) of National Institute of Health Sciences].
abstract: The raw material for chlormadinone acetate was tested for preparation of the "Chlormadinone Acetate Reference Standard (Control 961)" of National Institute of Health Sciences. Analytical data obtained were as follows: melting point, 215. 3 degrees C; UV spectrum, lambda max = 283.5 nm; IR spectrum, the same as that of JP Chlormadinone Acetate Reference Standard (Control 885); optical rotation, [alpha]20D = -13.0 degrees; thin-layer chromatography, one impurity was detected; high-performance liquid chromatography, two impurities were detected; loss on drying, 0.01%; assay, 99.4% by spectrophotometry and 99.5% by HPLC. Based on the above results, the raw material was authorized as the Chlormadinone Acetate Reference Standard (Control 961) of National Institute of Health Sciences (Japanese Pharmacopoeia).
authors.forename: A
authors.initials: A
authors.lastname: Kitajima
authors.forename: Y
authors.initials: Y
authors.lastname: Tagashira
authors.forename: K
authors.initials: K
authors.lastname: Maekawa
authors.forename: K
authors.initials: K
authors.lastname: Yoshii
authors.forename: H
authors.initials: H
authors.lastname: Komatsu
authors.forename: T
authors.initials: T
authors.lastname: Tanimoto
authors.forename: S
authors.initials: S
authors.lastname: Okada
mesh_terms: D002715:Chlormadinone Acetate / Q000592:standards*; D007564:Japan; D012015:Reference Standards
chemical_list: D002715:Chlormadinone Acetate