title: Clinical and stabilometric monitoring in a case of cerebellar atrophy with vitamin E deficiency.
abstract: The authors describe a case of early onset ataxia with cerebellar atrophy and vitamin E deficiency, treated with alpha-tocopherol supplementation and physically rehabilitated by postural biofeedback. Clinical assessments, serum vitamin E levels and postural evaluation by means of a stabilometric platform continued for about 2 years and significant clinical improvement was recorded. Our study confirms that combined physical therapy and vitamin E supplementation may result in improvement of cerebellar function. Motor improvement is directly related to vitamin E serum levels, providing further confirmation that normal vitamin E levels are crucial for proper brain functions.
authors.affiliation: Institute of Neurological Sciences, Unit of Neurometabolic Diseases, University of Siena, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Battisti
authors.forename: E D
authors.initials: ED
authors.lastname: Toffola
authors.forename: A P
authors.initials: AP
authors.lastname: Verri
authors.forename: E
authors.initials: E
authors.lastname: Serra
authors.forename: M T
authors.initials: MT
authors.lastname: Dotti
authors.forename: P
authors.initials: P
authors.lastname: Formichi
authors.forename: A
authors.initials: A
authors.lastname: Federico
mesh_terms: D000293:Adolescent; D001284:Atrophy; D001676:Biofeedback, Psychology; D002526:Cerebellar Diseases / Q000175:diagnosis* / Q000209:etiology*; D002531:Cerebellum / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D026741:Physical Therapy Modalities; D011187:Posture / Q000502:physiology; D014810:Vitamin E / Q000627:therapeutic use; D014811:Vitamin E Deficiency / Q000150:complications* / Q000503:physiopathology / Q000534:rehabilitation
chemical_list: D014810:Vitamin E