[Prenatal screening for major fetal defects by using of maternal serum markers].
OBJECTIVE
To investigate the effect of second-trimester maternal serum markers AFP, beta-hCG, uE3, for prenatal screening of the fetal defects.


METHODS
In 677 women the triple markers were measured. Some factors that may affect the testing such as maternal weight, gestational age, were adjusted on analyzing the result of the testing. Each woman, who underwent the triple screening, will be followed up until her fetus was delivered.


RESULTS
Among the women who were screened, 11 patients who presented at least one marker positive were identified as having an abnormal fetus, and the positive rate was 1.6%. While 32 women were confirmed to be false positive with a rate of 4.7%. Another 11 women had fetal demise on second-trimester, which had been proved to be not caused by fetal abnormality.


CONCLUSIONS
Maternal triple serum markers may take as a routine protocol for prenatal screening of the fetal defects.
Bao
P
P
First People's Hospital of Shanghai.
Wu
Y
Y
Gu
Q
Q
D000328:Adult; D000757:Anencephaly / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood*; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D004964:Estriol / Q000097:blood; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis*; D006801:Humans; D009436:Neural Tube Defects / Q000175:diagnosis; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011296:Prenatal Diagnosis / Q000379:methods*; D000509:alpha-Fetoproteins / Q000032:analysis
D015415:Biomarkers; D018997:Chorionic Gonadotropin, beta Subunit, Human; D000509:alpha-Fetoproteins; D004964:Estriol