title: No serotonin 5-HT2A receptor density abnormality in the cortex of schizophrenic patients studied with PET.
abstract: To investigate putative abnormalities of cortical 5-HT2A receptor density in schizophrenia, we used positron emission tomography and [18F]setoperone, a high-affinity 5-HT2A receptor radioligand, in 14 neuroleptic-free or -naive schizophrenic patients and in 15 normal controls. No significant difference between the groups was observed in the whole or regional cortical binding potential of [18F]setoperone, indicating an absence of major 5-HT2A receptor cortical density abnormalities in schizophrenics.
authors.affiliation: INSERM U334, S.H.F.J., DRM, DSV, CEA, Orsay, France.
authors.forename: C
authors.initials: C
authors.lastname: Trichard
authors.forename: M L
authors.initials: ML
authors.lastname: Paillère-Martinot
authors.forename: D
authors.initials: D
authors.lastname: Attar-Levy
authors.forename: J
authors.initials: J
authors.lastname: Blin
authors.forename: A
authors.initials: A
authors.lastname: Feline
authors.forename: J L
authors.initials: JL
authors.lastname: Martinot
mesh_terms: D000328:Adult; D002452:Cell Count; D002540:Cerebral Cortex / Q000000981:diagnostic imaging* / Q000378:metabolism*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D011744:Pyrimidinones / Q000493:pharmacokinetics; D011985:Receptors, Serotonin / Q000378:metabolism*; D012559:Schizophrenia / Q000000981:diagnostic imaging* / Q000378:metabolism*; D014055:Tomography, Emission-Computed
chemical_list: D011744:Pyrimidinones; D011985:Receptors, Serotonin; C045359:setoperone