title: Bacterial genotype and neurological complications of Escherichia coli O157:H7-associated haemolytic uraemic syndrome.
abstract: We examined the possibility of an association between the bacterial genotype of Escherichia coli O157:H7 and the likelihood of progression to neurological complications in childhood gastroenteritis-associated haemolytic uraemic syndrome (D+HUS). Bacterial stool isolates were available from 51 patients with HUS; 11 of these patients suffered a neurological complication. Bacteria were assessed for plasmid content, verotoxin (Shiga-like toxin) profile, verotoxin 2 subtype, and presence of the eaeA (effacement and attachment) marker. No association of bacterial genotype with central nervous system (CNS) manifestations was observed. Whilst the cause of CNS manifestations may be multifactorial, there is no evidence at present to implicate specific bacterial traits.
authors.affiliation: Department of Pathology and Laboratory Medicine, British Columbia's Children's Hospital, The University of British Columbia, Vancouver, Canada.
authors.forename: N
authors.initials: N
authors.lastname: Cimolai
authors.forename: J E
authors.initials: JE
authors.lastname: Carter
mesh_terms: D001427:Bacterial Toxins; D002493:Central Nervous System Diseases / Q000209:etiology / Q000382:microbiology*; D002648:Child; D002675:Child, Preschool; D004927:Escherichia coli Infections / Q000150:complications*; D019453:Escherichia coli O157 / Q000235:genetics*; D005260:Female; D005838:Genotype; D006463:Hemolytic-Uremic Syndrome / Q000209:etiology / Q000382:microbiology*; D006801:Humans; D007223:Infant; D008297:Male; D010957:Plasmids; D022622:Shiga Toxin 1
chemical_list: D001427:Bacterial Toxins; D022622:Shiga Toxin 1