title: [Nucleolar apparatus of neurosecretory cells in the hypothalamus of rats of different age during acute immobilization stress].
abstract: To determine condition and adaptive capacity of cell nucleoli at ageing, the effect of acute immobilization on the hypothalamic neurosecretory cells was investigated in young and old male Wistar rats. Using immunohistochemical methods and nucleolometry we have shown that: 1) the nuclear volume in all neurosecretory cells is increased; 2) the share of cells, containing nucleoli with marginal position or multiple nucleoli in the nuclei, displays opposite changes in young and in old rats under stress condition. We suppose that adaptive mechanisms are different in young and old animals. Although, both kinds of morphological reorganization result in the increase in functional activity.
authors.affiliation: Institute of Evolutionary Biochemistry and Physiology, Russian Academy of Sciences, St. Petersburg.
authors.forename: E D
authors.initials: ED
authors.lastname: Bazhanova
authors.forename: E V
authors.initials: EV
authors.lastname: Chernigovskaia
authors.forename: O A
authors.initials: OA
authors.lastname: Danilova
authors.forename: I A
authors.initials: IA
authors.lastname: Bazhanov
mesh_terms: D000208:Acute Disease; D000375:Aging; D000818:Animals; D002452:Cell Count; D002466:Cell Nucleolus / Q000378:metabolism / Q000648:ultrastructure*; D007031:Hypothalamus / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure*; D007103:Immobilization; D008297:Male; D009490:Neurosecretory Systems / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure*; D010121:Oxytocin / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000378:metabolism / Q000473:pathology*; D014667:Vasopressins / Q000378:metabolism
chemical_list: D014667:Vasopressins; D010121:Oxytocin
vernacular_title: Kharakteristika iadryshkovogo apparata neĭrosekretornykh kletok gipotalamusa u krys raznogo vosrasta pri ostroĭ immobilizatsii zhivotnykh.