Anti-acetylcholinesterase antibody in myasthenic syndrome.
OBJECTIVE
To examine the relationship between antibodies to acetylcholinesterase and myasthenic syndrome.


METHODS
Serum class specific antibodies to acetylcholinesterase and acetylcholine receptor were prepared with solid phase enzyme-linked immunosorbent assay in 51 patients with myasthenic syndrome, 31 controls with other neurological diseases (diseased controls) and 44 normal controls.


RESULTS
The positive rate of anti-acetylcholinesterase antibody in patients with myasthenic syndrome was 25%, while the results of the other two control groups were negative. Furthermore, the positive rate in patients without myasthenia gravis was 45%, which was much higher than that (13%) in those with myasthenic gravis.


CONCLUSIONS
Anti-acetylcholinesterase antibody may play a role in the pathogenesis of myasthenic syndrome.
Tang
J
J
Department of Neurology, First Affiliated Hospital of Beijing Medical University, China.
Yuan
J
J
Hao
H
H
D000110:Acetylcholinesterase / Q000276:immunology*; D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D003680:Deglutition Disorders / Q000276:immunology; D004417:Dyspnea / Q000276:immunology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D018908:Muscle Weakness / Q000276:immunology; D009157:Myasthenia Gravis / Q000276:immunology*; D013577:Syndrome
D001323:Autoantibodies; D000110:Acetylcholinesterase