Effect of 4-phenyl-1,3-dithia-2-thioxo-cyclopent-4-ene on liver injury induced by repeated exposure to galactosamine plus carbon tetrachloride in rats.
The protective effects of 1,3-dithia-2-thioxo-cyclopent-4-ene (DT827A),4-phenyl-1,3-dithia-2-thioxo-cyclopent- 4-ene (DT827B) and 4-(4-fluorophenyl)-1,3-dithia-2-thioxo-cyclopent-4-ene (DT827C) on liver injury induced by D-galactosamine plus carbon tetrachloride (D-GalN + CCl4) and that of DT827B on liver injury induced by thioacetamide were studied using male rats. Out of the three DT827 series of compounds, DT827B was more effective on liver injury induced by the combination exposure to D-GalN + CCl4 for 4 weeks, and accordingly the following two experiments were carried out using DT827B only. Twelve-week administration of DT827B at dose levels of 5, 10 and 20 mg/kg/day revealed a therapeutic effect against liver injury induced by D-GalN + CCl4 dose-dependently, and another twelve-week administration of DT827B at the same three dose levels also revealed a therapeutic effect against liver injury induced by thioacetamide dose-dependently. A hepatoprotective potential of DT827B was suggested under the conditions of these studies.
Sadanobu
S
S
Department of Hygienic Chemistry, College of Pharmacy, Nihon University, Chiba, Japan.
Takeuchi
M
M
Tezuka
M
M
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000517:prevention & control*; D056486:Chemical and Drug Induced Liver Injury; D004305:Dose-Response Relationship, Drug; D005688:Galactosamine / Q000008:administration & dosage / Q000506:poisoning*; D006573:Heterocyclic Compounds, 1-Ring / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008107:Liver Diseases / Q000517:prevention & control*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013853:Thioacetamide / Q000506:poisoning; D013871:Thiones / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
C111193:1,3-dithia-2-thioxocyclopent-4-ene; C111195:4-(4-fluorophenyl)-1,3-dithia-2-thioxocyclopent-4-ene; C111194:4-phenyl-1,3-dithia-2-thioxocyclopent-4-ene; D006573:Heterocyclic Compounds, 1-Ring; D013871:Thiones; D013853:Thioacetamide; D005688:Galactosamine