title: Retinoblastoma protein expression in ovarian epithelial neoplasms.
abstract: Progress has been made in identifying the molecular changes that occur in ovarian carcinoma; still our understanding of these changes and their interactions remains incomplete. In the present study the authors examined the expression of retinoblastoma protein, a tumor suppressor protein, in a spectrum of ovarian epithelial tumors including cystadenomas, low-malignant-potential tumors, and carcinomas. A heterogeneous pattern of reactivity was observed in all of the cystadenomas, in all of the low-malignant-potential tumors, and in a majority (27/34) of the carcinomas. The remaining carcinomas showed either a complete absence of reactivity or a pattern of altered reactivity characterized by areas of tumor with intact reactivity adjacent to zones of tumor with a complete absence of reactivity. There was no significant association between grade or stage and absent/altered reactivity. We conclude that alterations of retinoblastoma protein expression are uncommon in ovarian carcinoma.
authors.affiliation: Department of Pathology, Ohio State University Hospital, Columbus, USA.
authors.forename: T H
authors.initials: TH
authors.lastname: Niemann
authors.forename: T L
authors.initials: TL
authors.lastname: Trgovac
authors.forename: V R
authors.initials: VR
authors.lastname: McGaughy
authors.forename: G S
authors.initials: GS
authors.lastname: Lewandowski
authors.forename: L J
authors.initials: LJ
authors.lastname: Copeland
mesh_terms: D002277:Carcinoma / Q000737:chemistry* / Q000235:genetics; D003537:Cystadenoma / Q000737:chemistry* / Q000235:genetics; D004848:Epithelium / Q000737:chemistry; D005260:Female; D015870:Gene Expression; D016147:Genes, Tumor Suppressor; D006801:Humans; D007150:Immunohistochemistry; D010051:Ovarian Neoplasms / Q000737:chemistry* / Q000235:genetics; D011379:Prognosis; D016160:Retinoblastoma Protein / Q000032:analysis* / Q000096:biosynthesis
chemical_list: D016160:Retinoblastoma Protein