title: Congenital melanocytic nevi with placental infiltration by melanocytes: a benign condition that mimics metastatic melanoma.
abstract: BACKGROUND
  Placental metastases from cutaneous malignant melanoma from both the mother and the fetus have been reported. The finding of benign-appearing melanocytes in the placenta in association with congenital melanocytic nevi (CMN) is more exceptional, with only 6 reports in the literature. Clinically, the finding of melanocytes in the placenta in this setting can be alarming and might erroneously lead to the diagnosis of metastatic melanoma.
  
  
  METHODS
  Herein, we describe 3 additional patients with CMN with placental infiltration by melanocytes with a benign phenotype. In the results of immunoperoxidase stains, the melanocytic cells were positive for S-100 protein and HMB-45 in the 2 lesions available for study. Staining of placental vessels with Ulex europaeus agglutinin I (Vector Laboratories, Burlingame, Calif) failed to show intravascular melanocytes in the 1 lesion available for study. We report for the first time DNA diploidy in 2 lesions available for study, which were analyzed by DNA image cytometry. We describe the first patient with a relatively small, nongiant CMN.
  
  
  CONCLUSIONS
  We support the notion of the aberrant migration of melanocytes from the neural crest during fetal development as the most likely explanation of this phenomenon and note the similarity to the association of CMN and leptomeningeal melanocytosis. However, the precise histogenesis of this process remains uncertain. Most importantly, our data provide further evidence for the benign nature of this condition. Awareness of this entity is of vital importance in avoiding overdiagnosis of melanoma in this clinical setting.
authors.affiliation: Division of Dermatopathology, Harvard Medical School, Brigham and Women's Hospital, Boston, Mass, USA.
authors.forename: R A
authors.initials: RA
authors.lastname: Ball
authors.forename: D
authors.initials: D
authors.lastname: Genest
authors.forename: M
authors.initials: M
authors.lastname: Sander
authors.forename: B
authors.initials: B
authors.lastname: Schmidt
authors.forename: R L
authors.initials: RL
authors.lastname: Barnhill
mesh_terms: D000293:Adolescent; D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008544:Melanocytes / Q000473:pathology*; D009508:Nevus, Pigmented / Q000151:congenital / Q000175:diagnosis* / Q000473:pathology; D010922:Placenta Diseases / Q000151:congenital / Q000175:diagnosis* / Q000473:pathology; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis* / Q000473:pathology; D012878:Skin Neoplasms / Q000151:congenital / Q000175:diagnosis* / Q000473:pathology