title: The cytochromes P450 and mechanisms of chemical carcinogenesis.
abstract: This article reviews mechanisms of chemical carcinogenesis, from metabolic activation and generation of reactive oxygen species by cytochromes P4511 and P4502E to DNA damage, activation of protein kinase C and ocogenes, hyperplasia, and proteoglycan changes in the cell glycocalyx and lysosomal enzymes which mediate invasion and metastasis.
authors.affiliation: Division of Molecular Toxicology, School of Biological Sciences, University of Surrey, Guilford, UK.
authors.forename: D V
authors.initials: DV
authors.lastname: Parke
mesh_terms: D001711:Biotransformation; D002273:Carcinogens / Q000009:adverse effects* / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004249:DNA Damage; D006801:Humans; D009369:Neoplasms / Q000209:etiology*; D009857:Oncogenes / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D002273:Carcinogens; D017382:Reactive Oxygen Species; D003577:Cytochrome P-450 Enzyme System