title: Cyclophosphamide-induced changes of serum angiotensin converting enzyme activity and pulmonary microvessels ultrastructure.
abstract: The effect of cyclophosphamide (CP) on the ultrastructure of the lung tissue and the activity of angiotensin converting enzyme (ACE) in serum was evaluated in rats. The animals were given cyclophosphamide (CP) in a single intraperitoneal dose of 150 mg/kg b.w. ACE activity was evaluated in the blood serum collected from the left ventricle of the heart using the spectrophometric method. In all time subgroups, the CP-receiving animals showed a decrease in ACE activity. Ultrastructural examinations of CP-treated animals revealed increased adhesion of neutrophiles and monocytes to the damage endothelium of the alveolar septa vessels and focally accumulation of the platelets.
authors.affiliation: Department of Pathological Anatomy, Medical Academy of Białystok.
authors.forename: B
authors.initials: B
authors.lastname: Musiatowicz
authors.forename: S
authors.initials: S
authors.lastname: Terlikowski
authors.forename: M
authors.initials: M
authors.lastname: Sulik
authors.forename: W
authors.initials: W
authors.lastname: Famulski
authors.forename: J
authors.initials: J
authors.lastname: Giedrojć
authors.forename: A
authors.initials: A
authors.lastname: Jakubowski
authors.forename: M
authors.initials: M
authors.lastname: Sobaniec-Lotowska
authors.forename: L
authors.initials: L
authors.lastname: Pasztaleniec
authors.forename: M
authors.initials: M
authors.lastname: Baltaziak
authors.forename: E
authors.initials: E
authors.lastname: Jabłońska
mesh_terms: D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000633:toxicity*; D002196:Capillaries / Q000187:drug effects / Q000648:ultrastructure; D003520:Cyclophosphamide / Q000633:toxicity*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000648:ultrastructure; D008168:Lung / Q000098:blood supply*; D008297:Male; D008854:Microscopy, Electron; D007703:Peptidyl-Dipeptidase A / Q000097:blood*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D018906:Antineoplastic Agents, Alkylating; D003520:Cyclophosphamide; D007703:Peptidyl-Dipeptidase A