title: [Development of a test system for detection of anti-endotoxic immunity in young children, healthy donors and some groups of therapeutic patients].
abstract: The content of antibodies to soluble lipid A detritus was studied with the use of the enzyme immunoassay techniques. Some regularities of anti-endotoxic immunity were established: the elevated level of anti-lipid A antibodies in chronic bronchial tree diseases of bacterial etiology. On the other hand, cases of severe purulent septic infections in young children were found to be accompanied by a considerable decrease in the titer of anti-endotoxic antibodies. The approaches to the therapy of diseases caused by Gram-negative bacteria by means of specific immunoglobulins are discussed.
authors.affiliation: Medical Academy, Perm, Russia.
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Uvitskiĭ
authors.forename: L Iu
authors.initials: LIu
authors.lastname: Pagnueva
authors.forename: E D
authors.initials: ED
authors.lastname: Popova
authors.forename: R B
authors.initials: RB
authors.lastname: Khasanova
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood*; D001424:Bacterial Infections / Q000276:immunology; D001982:Bronchial Diseases / Q000276:immunology; D004731:Endotoxins / Q000276:immunology*; D006801:Humans; D007109:Immunity / Q000502:physiology*; D007124:Immunoenzyme Techniques; D007223:Infant; D007231:Infant, Newborn; D008050:Lipid A / Q000276:immunology*; D008070:Lipopolysaccharides / Q000302:isolation & purification*; D012016:Reference Values; D012995:Solubility
chemical_list: D000907:Antibodies, Bacterial; D004731:Endotoxins; D008050:Lipid A; D008070:Lipopolysaccharides
vernacular_title: Razrabotka test-sistemy dlia detektsii antiéndotoksicheskogo immuniteta u deteĭ rannego vozrasta, zdorovykh donorov i nekotorykh grupp terapevticheskikh bol'nykh.