title: Field evaluation of a topical doramectin formulation for the chemoprophylaxis of parasitic bronchitis in calves.
abstract: A study was conducted to evaluate the efficacy of two topical treatments with doramectin on the season-long control of lungworm and gastrointestinal infections in first grazing season (FGS) calves. At the start of the study, 20 FGS calves were randomly allocated into two treatment groups of 10 animals each. Calves in the D-group were treated with doramectin pour-on on days 0 and 56, at a dosage of 500 microg kg(-1) BW: calves in the C-group were designated as controls. A permanent pasture was divided in two blocks and these were randomly allocated to the treatment groups. Throughout the study, tracers (n = 32) were grazed on each paddock at 3-week intervals. Clinical signs of parasitic bronchitis (PB) were observed in the C-group in July and this necessitated two salvage treatments with levamisole. From day 28, post-turnout lungworm larvae were recovered from faeces of the C-calves until housing. No signs of PB were observed in the D-group during the entire grazing season. Shedding of lungworm larvae in the principals of the D-group did not occur until 112 days post-turnout. From the data obtained from the tracer calves. it appeared that larvae had overwintered on both pastures. On the C-pasture, the number of lungworms recovered from the tracer calves gradually increased to a peak in September, whereas on the D-pasture, the increase was observed only at the end of the pasture season. Both strongyle faecal egg counts and pepsinogen levels were relatively low in both groups throughout the present study. At the end of the grazing period (day 161). the principals were housed and treated with oxfendazole. During the housing period, all principal animals (D- and C-groups) and a third group of four helminth free animals (N-group) received a challenge infection with Dictyocaulus viviparus. It appeared that the different exposure to the parasite during the grazing season resulted in different establishment rates, i.e.. group C < group D < group N. The present results show that overwintering of lungworm larvae occurs in Belgium and that in such conditions, doramectin pour-on given at turnout and at 8 weeks controls PB in calves during the first grazing season.
authors.affiliation: Faculty of Veterinary Medicine, University of Gent, Department of Virology, Parasitology and Immunology, Merelbeke, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Vercruysse
authors.forename: P
authors.initials: P
authors.lastname: Dorny
authors.forename: E
authors.initials: E
authors.lastname: Claerebout
authors.forename: A
authors.initials: A
authors.lastname: Weatherley
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage* / Q000627:therapeutic use; D001530:Belgium; D001562:Benzimidazoles / Q000627:therapeutic use; D001835:Body Weight; D001991:Bronchitis / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy / Q000517:prevention & control*; D004021:Dictyocaulus / Q000187:drug effects / Q000276:immunology; D004022:Dictyocaulus Infections / Q000276:immunology / Q000517:prevention & control; D005243:Feces / Q000469:parasitology; D007411:Intestinal Diseases, Parasitic / Q000517:prevention & control / Q000662:veterinary; D007559:Ivermectin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008174:Lung Diseases, Parasitic / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*; D008297:Male; D010028:Ostertagia / Q000737:chemistry; D010270:Parasite Egg Count / Q000662:veterinary; D010435:Pepsinogens / Q000097:blood; D011897:Random Allocation; D014251:Trichostrongyloidea / Q000737:chemistry
chemical_list: D000871:Anthelmintics; D001562:Benzimidazoles; D010435:Pepsinogens; D007559:Ivermectin; C084101:doramectin; C011030:oxfendazole