Linear IgA disease and ulcerative colitis.
Linear IgA disease is an acquired bullous disease of the skin characterized by linear IgA deposits along the dermal-epidermal junction. Inflammatory bowel diseases have been rarely reported in association with linear IgA disease. We have recently observed a patient suffering from ulcerative colitis who developed a cutaneous bullous eruption that was diagnosed as a linear IgA disease. Foreign antigens penetrating the inflamed bowel mucosa might give rise to the production of autoantibodies cross-reacting with the cutaneous antigens involved in the pathogenesis of linear IgA disease.
De Simone
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Department of Dermatology Università Cattolica del Sacro Cuore, Largo A. Gemelli, 8, 00168 Roma, Italy.
Guerriero
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Pellicano
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D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D001485:Basement Membrane / Q000737:chemistry; D003093:Colitis, Ulcerative / Q000150:complications* / Q000276:immunology; D003622:Dapsone / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D008297:Male; D012872:Skin Diseases, Vesiculobullous / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D016896:Treatment Outcome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007070:Immunoglobulin A; D003622:Dapsone