[The effect of serotonin antibodies on the behavior of C57Bl/6 mice in an open field and on the level of monoamines in the brain structures].
Mice of C57BL/6 strain were singly injected intraperitoneally with antibodies (AB) to serotonin (5-HT). The "open-field" testing in different periods after the AB injection revealed a depression of behavior within 1.5 h which changed for activation within 1 day and, again, depression within 5 days after the injection. The analysis of neurotransmitter content in the sensorimotor cortex and hypothalamus revealed increased levels of serotonin and, especially, dopamine in the cortex within 1 day. The cortex serotonin level within 5 days was also increased. The possible mechanisms are discussed of neurotropic action of AB to 5-HT.
Trekova
N A
NA
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
Khlopushina
T G
TG
Basharova
L A
LA
Vetrilé
L A
LA
Mikovskaia
O I
OI
Evseev
V A
VA
D000818:Animals; D000906:Antibodies / Q000302:isolation & purification / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D015306:Biogenic Monoamines / Q000032:analysis*; D001923:Brain Chemistry / Q000187:drug effects; D004298:Dopamine / Q000032:analysis; D007031:Hypothalamus / Q000737:chemistry / Q000187:drug effects*; D007114:Immunization / Q000379:methods; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000502:physiology*; D009044:Motor Cortex / Q000737:chemistry / Q000187:drug effects*; D011817:Rabbits; D012701:Serotonin / Q000032:analysis / Q000276:immunology*; D013997:Time Factors
D000906:Antibodies; D015306:Biogenic Monoamines; D012701:Serotonin; D004298:Dopamine
Vliianie antitel k serotoninu na povedenie mysheĭ C57Bl/6 v otkrytom pole i soderzhanie monoaminov v strukturakh golovnogo mozga.