[Protective effects of radix Salviae miltiorrhizae on azathioprine hepatotoxicity in rats].
The changes of liver function and malondialdehyde (MDA) and glutathione (GSH) were studied in rats intoxicated with azathioprine (Aza) 15mg/(kg.d) and in rats treated with Aza mixed Salviae 8g/(kg.d). The results showed that in the Aza group, the levels of ALT, AKP, MDA increased and GSH decreased significantly in week 1 and week 2. But in the Salviae group the levels of ALT, AKP, MDA decreased and GSH increased significantly, approaching the normal levels, It follows that Salviae has protective effects on Aza hepatotoxicity in rats.
Sun
C
C
General Hospital of Jinan Military District.
Chen
D
D
Qu
Z
Z
Hao
J
J
Wang
J
J
D000818:Animals; D001379:Azathioprine; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005978:Glutathione / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D010936:Plant Extracts; D051381:Rats; D017208:Rats, Wistar; D027561:Salvia miltiorrhiza
D004365:Drugs, Chinese Herbal; D016166:Free Radical Scavengers; D010936:Plant Extracts; D008315:Malondialdehyde; D005978:Glutathione; D001379:Azathioprine