Reproducibility of 1H-NMR integrals: a collaborative study.
The quantitative use of NMR spectroscopy was investigated by a reproducibility study of 1H-NMR integrals involving five laboratories. A significant laboratory effect was found confirming the difficulty to obtain very precise data by integration of complex signals. The reproducibility of any NMR assay measurement, which requires a high precision should be validated by an interlaboratory study.
Bauer
M
M
Sanofi Recherche, Toulouse, France.
Bertario
A
A
Boccardi
G
G
Fontaine
X
X
Rao
R
R
Verrier
D
D
D005069:Evaluation Studies as Topic; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D015203:Reproducibility of Results