[Changes of lipid metabolism in cardiac failure patients with rheumatic heart disease].
OBJECTIVE
The study of lipid metabolism parameters involved in lipid mechanisms of damage and elucidation of their role in disorders of central hemodynamics (CH), microcirculation (MC) and oxygenation (OG) of peripheral tissues in cardiac failures (CF) in rheumatic patients.


METHODS
In 55 patients with rheumatic heart disease (RHD) with CF measurements were made of serum characteristics of peroxidation-antioxidant balance, activity of phospholipase A2, concentration of nonesterifized fatty acids, total lipids, total phospholipids, total, ether-bound and free cholesterol, skin OG and MC. Tetrapolar chest rheography was followed by calculation CH parameters.


RESULTS
CF aggravation occurred in parallel with progression of generalized activation of lipid peroxidation (LPO) and phospholipase A2. LPO activation contributes to inhibition of antioxidant activity and to decline of hypercholetsrolemia. Negative correlation exists between primary LPO products, dienic conjugates and CH.


CONCLUSIONS
LPO and phospholipase A2 activation are essential in the onset and progression of CF in RHD patients. This should be considered in therapy of such patients.
Chizhov
P A
PA
Bobylev
V Ia
VIa
D006333:Heart Failure / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood*; D008875:Middle Aged; D010992:Plethysmography, Impedance; D012214:Rheumatic Heart Disease / Q000097:blood* / Q000150:complications / Q000503:physiopathology
D008055:Lipids
Izmenenie lipidnogo obmena pri serdechnoĭ nedostatochnosti u bol'nykh s revmaticheskimi prokami serdtsa.