A review of tumor suppressor genes in cutaneous neoplasms with emphasis on cell cycle regulators.
Cells normally have five options. These include renewal or proliferation, terminal differentiation, quiescence, senescence, and apoptosis. Many factors interact with cell cycle regulators to direct the cells toward these different options. Tumor suppressor genes play a pivotal role in this process. Alterations in these genes may limit the options that cells have and thus play a significant role in the multistep process of carcinogenesis. We will focus on tumor suppressor genes and especially tumor suppressor genes that interact directly with the cell cycle proteins.
Smith
K J
KJ
National Naval Medical Center, Bethesda, Maryland, USA.
Barrett
T L
TL
Smith
W F
WF
Skelton
H M
HM
D018797:Cell Cycle Proteins / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D016147:Genes, Tumor Suppressor / Q000235:genetics / Q000502:physiology*; D018816:Genes, cdc / Q000502:physiology; D006801:Humans; D012867:Skin / Q000166:cytology / Q000473:pathology; D012878:Skin Neoplasms / Q000235:genetics / Q000503:physiopathology*
D018797:Cell Cycle Proteins