title: Single-fraction stereotactic radiotherapy: a dose-response analysis of arteriovenous malformation obliteration.
abstract: OBJECTIVE
  Stereotactic radiotherapy delivered in a high-dose single fraction is an effective technique to obliterate intracranial arteriovenous malformations (AVM). To attempt to analyze the relationships between dose, volume, and obliteration rates, we studied a group of patients treated using single-isocenter treatment plans.
  
  
  METHODS
  From May 1986 to December 1989, 100 consecutive patients with angiographically proven AVM had stereotactic radiotherapy delivered as a high-dose single fraction using a single-isocenter technique. Distribution according to Spetzler-Martin grade was as follows: 79 grade 1-3, three grade 4, 0 grade 5, and 18 grade 6. The target volume was spheroid in 74 cases, ellipsoid in 11, and large and irregular in 15. The targeted volume of the nidus was estimated using two-dimensional stereotactic angiographic data and, calculated as an ovoid-shaped lesion, was 1900 +/- 230 mm3 (median 968 mm3; range 62-11, 250 mm3). The mean minimum target dose (Dmin) was 19 +/- 0.6 Gy (median 20 Gy; range: 3-31.5). The mean volume within the isodose which corresponded to the minimum target dose was 2500 +/- 300 mm3 (median 1200 mm3; range 75-14 900 mm3). The mean maximum dose (Dmax) was 34.5 +/- 0.5 Gy (median 35 Gy; range 15-45). The mean angiographic follow-up was 42 +/- 2.3 months (median 37.5; range 7-117).
  
  
  RESULTS
  The absolute obliteration rate was 51%. The 5-year actuarial obliteration rate was 62.5 +/- 7%. After univariate analysis, AVM obliteration was influenced by previous surgery (p = 0.0007), Dmin by steps of 5 Gy (p = 0.005), targeted volume of the nidus (< or = 968 mm3 vs. >968 mm3; p = 0.015), and grade according to Spetzler-Martin (grade 1-3 vs. grade 4-6; p = 0.011). After multivariate analysis, the independent factors influencing AVM obliteration were the Dmin [relative risk (RR) 1.9; 95% confidence interval (CI) 1.4-2.5; p < 0.0001] and grade distribution according to Spetzler-Martin (RR 1.4; 95% CI 1.1-1.7; p = 0.010). Delayed complications were observed in eight patients. The 5-year actuarial rate of delayed complications was 7.4%.
  
  
  CONCLUSIONS
  After stereotactic radiotherapy delivered in a single high dose using a single-isocenter technique, the success rate for complete obliteration is independently correlated to Dmin but does not seem to be influenced by Dmax and the targeted volume of the nidus.
authors.affiliation: Department of Radiation Oncology, Tenon Hospital, Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: Touboul
authors.forename: A
authors.initials: A
authors.lastname: Al Halabi
authors.forename: L
authors.initials: L
authors.lastname: Buffat
authors.forename: L
authors.initials: L
authors.lastname: Merienne
authors.forename: J
authors.initials: J
authors.lastname: Huart
authors.forename: M
authors.initials: M
authors.lastname: Schlienger
authors.forename: D
authors.initials: D
authors.lastname: Lefkopoulos
authors.forename: H
authors.initials: H
authors.lastname: Mammar
authors.forename: O
authors.initials: O
authors.lastname: Missir
authors.forename: J F
authors.initials: JF
authors.lastname: Meder
authors.forename: A
authors.initials: A
authors.lastname: Laurent
authors.forename: M
authors.initials: M
authors.lastname: Housset
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D002648:Child; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery / Q000379:methods*