title: Uveal lymphoid infiltration. Report of four cases and clinicopathologic review.
abstract: OBJECTIVE
  The purpose of the study was to report the clinicopathologic features of four patients with uveal lymphoid infiltration who were diagnosed by a conjunctival biopsy.
  
  
  METHODS
  A case series.
  
  
  METHODS
  Four patients at four institutions participated.
  
  
  METHODS
  The histopathologic findings of the conjunctival and episcleral biopsy specimens from four patients with the diagnosis of uveal lymphoid infiltration were recorded. The conjunctival specimens were placed in 10% neutral buffered formaldehyde solution or B5 solution and processed routinely for light microscopic examination and immunohistochemical analysis for B cells and T cells and kappa and lambda light chains. The clinical and histopathologic findings were compared with 47 previously reported cases of uveal lymphoid infiltration.
  
  
  RESULTS
  Two men and two women (average age = 57 years) presented with diffuse punctate to coalescent yellow uveal infiltrates and epibulbar pink fleshy lesions. Ultrasonography of the lesions showed diffuse choroidal thickening and a lack of choroidal or scleral excavation. The conjunctival biopsy specimens showed diffuse infiltration of the substantia propria with B lymphocytes with variable kappa and lambda restriction. Scattered T lymphocytes also were present. Plasmacytoid cells and a prominent Grenz zone were present.
  
  
  CONCLUSIONS
  Patients with solitary or multiple yellow uveal infiltrates should have careful conjunctival evaluation for the presence of pink conjunctival lesions. Biopsy specimens of the conjunctival lesion may establish the diagnosis of uveal lymphoid infiltration.
authors.affiliation: Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: H E
authors.initials: HE
authors.lastname: Grossniklaus
authors.forename: D F
authors.initials: DF
authors.lastname: Martin
authors.forename: R
authors.initials: R
authors.lastname: Avery
authors.forename: J A
authors.initials: JA
authors.lastname: Shields
authors.forename: C L
authors.initials: CL
authors.lastname: Shields
authors.forename: I C
authors.initials: IC
authors.lastname: Kuo
authors.forename: R L
authors.initials: RL
authors.lastname: Green
authors.forename: N A
authors.initials: NA
authors.lastname: Rao
mesh_terms: D000328:Adult; D000368:Aged; D001402:B-Lymphocytes / Q000473:pathology; D001706:Biopsy; D003228:Conjunctiva / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010950:Plasma Cells / Q000473:pathology; D019310:Pseudolymphoma / Q000000981:diagnostic imaging / Q000473:pathology*; D012590:Sclera / Q000000981:diagnostic imaging / Q000473:pathology; D013601:T-Lymphocytes / Q000473:pathology; D014463:Ultrasonography; D014603:Uveal Diseases / Q000000981:diagnostic imaging / Q000473:pathology*