title: Predictors of eyeblink classical conditioning over the adult age span.
abstract: The major aim was to identify predictors of the large age differences that exist in eyeblink classical conditioning. Eyeblink conditioning was assessed in 190 participants over the age range of 20-89 years, with 150 trained in the paired condition and 40 trained in the explicitly unpaired control condition. Timed-interval tapping was used to assess cerebellar function. Blink reaction time and explicit learning and memory were also assessed. Stepwise multiple regression indicated that the effect of age accounted for the largest proportion of the variance, but the cerebellar measure also predicted eyeblink conditioning at a significant level. Reaction time and explicit memory measures did not account for a significant amount of the variance in eyeblink conditioning. Age-related effects in the cerebellum apparently affect timing and learning in normal adults.
authors.affiliation: Department of Psychology, Temple University, Philadelphia, Pennsylvania 19122, USA. kioku@vm.temple.edu
authors.forename: D S
authors.initials: DS
authors.lastname: Woodruff-Pak
authors.forename: M E
authors.initials: ME
authors.lastname: Jaeger
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D000704:Analysis of Variance; D002531:Cerebellum / Q000502:physiology*; D003215:Conditioning, Eyelid / Q000502:physiology*; D016001:Confidence Intervals; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D008875:Middle Aged; D009048:Motor Skills / Q000502:physiology; D009483:Neuropsychological Tests; D011930:Reaction Time; D012044:Regression Analysis; D013996:Time and Motion Studies; D014888:Wechsler Scales