title: An experimental comparative study on the characteristics of ventricular fibrillation during cardiac arrest and methoxamine administration.
abstract: The effect of a pure alpha-adrenergic agent, methoxamine on ventricular fibrillation (VF) amplitude and the relation between hemodynamic parameters and survival in a rodent cardiopulmonary resuscitation (CPR) model were studied. Our results suggested that: 1) VF amplitude decreased during untreated VF, but it increased during pericardial chest compression: 2) methoxamine significantly increased the mean aortic pressure (MAP) and coronary perfusion pressure (CPP) but not VF amplitude, and the survival also increased due to elevation of CPP; and 3) all surviving animals with successful defibrillation had a higher VF amplitude.
authors.affiliation: Department of Thoracic and Cardiac Surgery, Tongji Hospital, Tongji Medical University, Wuhan. Wuhan.
authors.forename: T
authors.initials: T
authors.lastname: Pan
authors.forename: S
authors.initials: S
authors.lastname: Chau
authors.forename: M
authors.initials: M
authors.lastname: Von Planta
authors.forename: W
authors.initials: W
authors.lastname: Studer
authors.forename: D
authors.initials: D
authors.lastname: Scheidgger
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D016887:Cardiopulmonary Resuscitation; D004554:Electric Countershock; D006323:Heart Arrest / Q000503:physiopathology*; D008297:Male; D008729:Methoxamine / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014693:Ventricular Fibrillation / Q000503:physiopathology*
chemical_list: D000316:Adrenergic alpha-Agonists; D008729:Methoxamine