Toxicokinetics of trimethyltin in four inbred strains of mice.
Sixteen week old male AKR/J, Balb/cByJ, C57B1/6J and DBA/2J mice received single i.p. injections of trimethyltin (TMT). The toxic effects were weight loss, hyperexcitability, tremor, clonic-tonic convulsion, posterior paresis and death. The minimum toxic dose was 1.8 mg/kg, for the AKR strain and 2.3 mg/kg for the other strains. The highest non-lethal dose was 2.7 mg/kg for the AKR, DBA/2 and C57B1/6 strains and 3.0 mg/kg for the Balb/c strain. Blood levels of TMT peaked within 1 h and declined with half-lives of approximately 1.5 days. Blood levels of TMT were lower in the C57B1/6 mice due to greater tissue binding of TMT in C57B1/6 mice. Some of the toxic endpoints showed different rank orders among the strains, leading us to conclude that more than one biological process is responsible for the acute toxic effects of TMT in mice.
Ekuta
J E
JE
Department of Pharmacology, School of Pharmacy, The University of Mississippi, University 38677, USA.
Hikal
A H
AH
Matthews
J C
JC
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006207:Half-Life; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010291:Paresis / Q000139:chemically induced; D012640:Seizures / Q000139:chemically induced*; D013045:Species Specificity; D014202:Tremor / Q000139:chemically induced; D014298:Trimethyltin Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000633:toxicity*; D015431:Weight Loss / Q000187:drug effects
D014298:Trimethyltin Compounds; C046488:trimethyltin