title: Scaling of movement velocity: a measure of neuromotor retardation in individuals with psychopathology.
abstract: The study of motor slowness based on observational methods has limitations. Whether motor retardation has a psychomotor or neuromotor basis is unclear because psychiatric and motor symptoms overlap. Observational methods lack the precision necessary to distinguish cognitive from motor processes. For the present study, we used an objective measure of neuromotor dysfunction to quantify the extent to which an individual programs movement velocity in anticipation of increasing target distance. Persons with Parkinson's disease (PD) or functional psychosis were studied with a group of healthy comparison subjects. Results indicated that the slope of the linear function relating velocity to distance was abnormal in the PD group and in approximately half of the psychosis group. Analyses revealed the measure to have high specificity and sensitivity. Weak correlations between velocity scaling and psychopathology support the neuromotor basis of the measure. We conclude that this measure of velocity scaling is relatively uninfluenced by cognitive factors that may underlie psychomotor retardation.
authors.affiliation: Department of Psychiatry, University of California at San Diego, La Jolla 92058, USA. mcaligiuri@ucsd.edu
authors.forename: M P
authors.initials: MP
authors.lastname: Caligiuri
authors.forename: J B
authors.initials: JB
authors.lastname: Lohr
authors.forename: R K
authors.initials: RK
authors.lastname: Ruck
mesh_terms: D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use; D004409:Dyskinesia, Drug-Induced / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009469:Neuromuscular Junction / Q000187:drug effects / Q000503:physiopathology; D010300:Parkinson Disease / Q000175:diagnosis / Q000503:physiopathology*; D011434:Proprioception / Q000187:drug effects / Q000502:physiology; D011596:Psychomotor Disorders / Q000175:diagnosis / Q000503:physiopathology*; D011597:Psychomotor Performance / Q000187:drug effects / Q000502:physiology*; D011618:Psychotic Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology*; D012680:Sensitivity and Specificity
chemical_list: D014150:Antipsychotic Agents