Biocompatibility of two apatite cements.
Biocompatibility and osteogenic potential of two calcium phosphate cements (G-5 and G-6) and Super-EBA were investigated by subcutaneous and intraosseous implantation in 90 rats. Reactions were studied microscopically at 15, 30, and 60 days after implantation. Super-EBA was well tolerated by both soft and hard tissues. G-5 was highly biocompatible with resorption and bone replacement at intraosseous implantation sites. G-6 promoted moderate inflammation and a foreign body giant cell response over the 60-day study period. None of the materials elicited osteogenesis or dystrophic calcification at the subcutaneous implantation sites.
Steinbrunner
R L
RL
Department of Restorative Dentistry, Indiana University School of Dentistry, Indianapolis 46202-5186, USA.
Brown
C E
CE
Legan
J J
JJ
Kafrawy
A H
AH
D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology; D001842:Bone and Bones / Q000187:drug effects; D002130:Calcium Phosphates / Q000494:pharmacology*; D003738:Dental Cements / Q000494:pharmacology*; D017220:Dentin-Bonding Agents / Q000494:pharmacology; D005549:Foreign-Body Reaction / Q000145:classification; D015726:Giant Cells; D007249:Inflammation / Q000139:chemically induced*; D008297:Male; D010012:Osteogenesis / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012886:Skull
D001672:Biocompatible Materials; D002130:Calcium Phosphates; D003738:Dental Cements; D017220:Dentin-Bonding Agents; C084074:Super EBA