title: Quantitative and qualitative changes in intestinal goblet cells during primary infection of Trichostrongylus colubriformis high and low responder guinea pigs.
abstract: Small intestine goblet cell numbers and the composition of their mucus were compared in guinea pigs with genetically determined differences in responsiveness to Trichostrongylus colubriformis infection. Prior to infection, no differences between high responder and low responder animals were detected. However, following primary infection with T. colubriformis, pronounced goblet cell hyperplasia developed and the proportion of sulphomucin in these cells increased. Both changes developed significantly earlier in high responder animals.
authors.affiliation: Department of Veterinary Anatomy and Pathology, University of Sydney, NSW, Australia.
authors.forename: M H
authors.initials: MH
authors.lastname: Manjili
authors.forename: M P
authors.initials: MP
authors.lastname: France
authors.forename: N C
authors.initials: NC
authors.lastname: Sangster
authors.forename: T L
authors.initials: TL
authors.lastname: Rothwell
mesh_terms: D000818:Animals; D004198:Disease Susceptibility; D005243:Feces / Q000469:parasitology; D006168:Guinea Pigs; D006790:Host-Parasite Interactions; D007413:Intestinal Mucosa / Q000737:chemistry / Q000469:parasitology / Q000473:pathology*; D009077:Mucins / Q000032:analysis; D010270:Parasite Egg Count; D013194:Staining and Labeling; D013997:Time Factors; D014253:Trichostrongylosis / Q000276:immunology / Q000469:parasitology / Q000473:pathology*; D014254:Trichostrongylus / Q000502:physiology
chemical_list: D009077:Mucins