Transcription: gene control by targeted histone acetylation.
A transcriptional regulator in yeast, Gcn5p, activates transcription by targeted acetylation of specific lysine residues in the amino-terminal tails of histones. This targeted modification is restricted to nucleosomes assembled on the promoters of Gcn5p-responsive genes.
Imhof
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A
Laboratory of Molecular Embryology, NICHD, NIH, Bethesda, Maryland 20892-5431, USA. awlme@helix.nih.gov
Wolffe
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AP
D000107:Acetylation; D000123:Acetyltransferases / Q000378:metabolism*; D000818:Animals; D004268:DNA-Binding Proteins; D005656:Fungal Proteins / Q000378:metabolism*; D006657:Histones / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D011494:Protein Kinases / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000201:enzymology* / Q000235:genetics / Q000254:growth & development; D029701:Saccharomyces cerevisiae Proteins; D014158:Transcription, Genetic
D004268:DNA-Binding Proteins; D005656:Fungal Proteins; D006657:Histones; D029701:Saccharomyces cerevisiae Proteins; D000123:Acetyltransferases; D011494:Protein Kinases