Rifabutin-associated uveitis in an immunosuppressed pediatric patient without acquired immunodeficiency syndrome.
OBJECTIVE
To describe a case of bilateral, symptomatic rifabutin-associated uveitis with hypopyon and vitreal opacities in an immunosuppressed pediatric patient without acquired immunodeficiency syndrome (AIDS).


METHODS
Case report. An 8-year-old boy presented with bilateral uveitis 24 months after a bilateral lung transplant.


RESULTS
Our patient, whose medications included rifabutin, clarithromycin, and immunosuppressive agents, responded to discontinuation of the rifabutin and initiation of intensive topical corticosteroid therapy with complete resolution of the uveitis.


CONCLUSIONS
Rifabutin-associated uveitis may occur in a non-AIDS pediatric patient.
Jewelewicz
D A
DA
Edward S. Harkness Eye Institute, Columbia Presbyterian Medical Center, New York, NY 10032, USA. daj17@columbia.edu
Schiff
W M
WM
Brown
S
S
Barile
G R
GR
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D000904:Antibiotics, Antitubercular / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D005128:Eye Diseases / Q000139:chemically induced; D006801:Humans; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D008171:Lung Diseases / Q000188:drug therapy / Q000382:microbiology; D016040:Lung Transplantation; D008297:Male; D015270:Mycobacterium avium-intracellulare Infection / Q000188:drug therapy / Q000382:microbiology; D017828:Rifabutin / Q000009:adverse effects* / Q000627:therapeutic use; D014605:Uveitis / Q000139:chemically induced*; D014822:Vitreous Body / Q000187:drug effects*
D000904:Antibiotics, Antitubercular; D007166:Immunosuppressive Agents; D017828:Rifabutin