The cytochromes P450 and mechanisms of chemical carcinogenesis.
This article reviews mechanisms of chemical carcinogenesis, from metabolic activation and generation of reactive oxygen species by cytochromes P4511 and P4502E to DNA damage, activation of protein kinase C and ocogenes, hyperplasia, and proteoglycan changes in the cell glycocalyx and lysosomal enzymes which mediate invasion and metastasis.
Parke
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Division of Molecular Toxicology, School of Biological Sciences, University of Surrey, Guilford, UK.
D001711:Biotransformation; D002273:Carcinogens / Q000009:adverse effects* / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004249:DNA Damage; D006801:Humans; D009369:Neoplasms / Q000209:etiology*; D009857:Oncogenes / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000378:metabolism
D002273:Carcinogens; D017382:Reactive Oxygen Species; D003577:Cytochrome P-450 Enzyme System