In vivo microdialysis study of (+/-)-kavain on veratridine-induced glutamate release.
This is the first microdialysis study to address the effects of (+/-)-kavain on veratridine-induced glutamate release in freely moving rats. (+/-)-Kavain (100 mg/kg, p.o.) significantly reduced veratridine-induced glutamate release compared with that of vehicle-treated controls. Maximum extracellular glutamate levels were obtained 20-40 min after veratridine stimulation (500 microM, added to the perfusate). In the control group the increase was 301% and in the (+/-)-kavain group the increase was significantly reduced to 219% (the basal value was 100%). These results demonstrate that (+/-)-kavain reduces veratridine-induced glutamate release in vivo, which confirms previous in vitro data.
Ferger
B
B
Institute of Pharmacology and Toxicology, Faculty of Pharmacy, Philipps-University of Marburg, Germany. ferger@mailer.uni-marburg.de
Boonen
G
G
Häberlein
H
H
Kuschinsky
K
K
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004347:Drug Interactions; D018698:Glutamic Acid / Q000378:metabolism*; D008297:Male; D017551:Microdialysis; D011753:Pyrones / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013779:Tetrodotoxin / Q000494:pharmacology; D014701:Veratridine / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D000927:Anticonvulsants; D011753:Pyrones; D018698:Glutamic Acid; D013779:Tetrodotoxin; D014701:Veratridine; C011889:kavain