title: Detection of phosphomonoester signals in proton-decoupled 31P NMR spectra of the myocardium of patients with myocardial hypertrophy.
abstract: Proton-decoupled 31P NMR spectroscopy at 1.5 T of the anterior left ventricular myocardium was used to monitor myocardial phosphate metabolism in asymptomatic patients with hypertrophic cardiomyopathy (HCM, n = 14) and aortic stenosis (AS, n = 12). In addition to the well-known phosphorus signals a phosphomonoester (PME) signal was detected at about 6.9 ppm in 7 HCM and 2 AS patients. This signal was not observed in the spectra of normal controls (n = 11). We suggest that in spectra of patients with myocardial hypertrophy the presence of a PME signal reflects alterations in myocardial glucose metabolism.
authors.affiliation: Physikalisches Institut, University of Tübingen, Tübingen, 72076, Germany.
authors.forename: W I
authors.initials: WI
authors.lastname: Jung
authors.forename: L
authors.initials: L
authors.lastname: Sieverding
authors.forename: J
authors.initials: J
authors.lastname: Breuer
authors.forename: O
authors.initials: O
authors.lastname: Schmidt
authors.forename: S
authors.initials: S
authors.lastname: Widmaier
authors.forename: M
authors.initials: M
authors.lastname: Bunse
authors.forename: F
authors.initials: F
authors.lastname: van Erckelens
authors.forename: J
authors.initials: J
authors.lastname: Apitz
authors.forename: G J
authors.initials: GJ
authors.lastname: Dietze
authors.forename: O
authors.initials: O
authors.lastname: Lutz
mesh_terms: D019794:2,3-Diphosphoglycerate / Q000032:analysis; D000255:Adenosine Triphosphate / Q000032:analysis; D000293:Adolescent; D000328:Adult; D001024:Aortic Valve Stenosis / Q000378:metabolism; D002312:Cardiomyopathy, Hypertrophic / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000378:metabolism; D006352:Heart Ventricles / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D009206:Myocardium / Q000737:chemistry* / Q000378:metabolism; D009243:NAD / Q000032:analysis; D010755:Organophosphates / Q000032:analysis*; D010710:Phosphates / Q000378:metabolism; D010725:Phosphocreatine / Q000032:analysis; D010758:Phosphorus
chemical_list: D010755:Organophosphates; D010710:Phosphates; D010725:Phosphocreatine; D009243:NAD; D019794:2,3-Diphosphoglycerate; D010758:Phosphorus; D000255:Adenosine Triphosphate; D005947:Glucose