title: Tigloylcholine: a new choline ester toxin from the hypobranchial gland of two species of muricid gastropods (Thais clavigera and Thais bronni).
abstract: Crude extracts from hypobranchial glands of two species of muricid gastropods, Thais clavigera and Thais bronni, were highly lethal to mice. Regardless of species, a new choline ester was isolated as the major toxic principle and elucidated to be tigloylcholine, a structural isomer of senecioylcholine widely found in gastropod hypobranchial glands, by 1H- and 13C-NMR as well as FAB-MS. The i.v. LD50 (mouse) of tigloylcholine was estimated to be 0.92 mg/kg.
authors.affiliation: Department of Food Science and Technology, Tokyo University of Fisheries, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Shiomi
authors.forename: M
authors.initials: M
authors.lastname: Ishii
authors.forename: K
authors.initials: K
authors.lastname: Shimakura
authors.forename: Y
authors.initials: Y
authors.lastname: Nagashima
authors.forename: M
authors.initials: M
authors.lastname: Chino
mesh_terms: D000818:Animals; D002794:Choline / Q000031:analogs & derivatives* / Q000737:chemistry / Q000633:toxicity; D002855:Chromatography, Thin Layer; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008978:Mollusk Venoms / Q000737:chemistry / Q000633:toxicity*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013237:Stereoisomerism
chemical_list: D008978:Mollusk Venoms; C000840:senecioylcholine; D002794:Choline