[Effects of saponins from stems and leaves of Panax quinquefolium L. on the contraction of rabbit aortic strips].
It has been found out that the saponins from stems and leaves of Panax quinquefolium (PQS) can non-competitively antagonize the dose-response curves of norepinephrine (NE), potassium chloride and calcium chloride on the isolated aortic strips of rabbits, and obviously inhibit intracellular and extracellular Ca2(+)-dependent contraction of the aortic strips induced by NE. These effects of PQS are similar to verapamil.
Guan
L
L
Mudanjiang Medical College.
Yi
X
X
Feng
Q
Q
Yang
L
L
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D005260:Female; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D005894:Panax / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal; D011817:Rabbits; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology*
D002121:Calcium Channel Blockers; D012503:Saponins