Interactions between Wingless and Notch during the assignment of cell fates in Drosophila.
A large number of observations suggest that, during Drosophila development there are close functional interactions between the activity of Notch receptor and that of a signaling molecule encoded by wingless gene. In this essay, I summarize these interactions and discuss the possibility that Wingless acts as a ligand for Notch as part of a switch that is iteratively involved in the assignation of cell fates during development.
Martinez Arias
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Department of Zoology, University of Cambridge, United Kingdom. ama11@cus.cam.ac.uk
D000818:Animals; D019521:Body Patterning / Q000235:genetics / Q000502:physiology*; D002454:Cell Differentiation; D004330:Drosophila / Q000235:genetics / Q000254:growth & development*; D029721:Drosophila Proteins; D005812:Genes, Switch; D008024:Ligands; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology*; D021382:Protein Sorting Signals / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000502:physiology*; D051880:Receptors, Notch; D051155:Wnt1 Protein
D029721:Drosophila Proteins; D008024:Ligands; D008565:Membrane Proteins; C497759:N protein, Drosophila; D021382:Protein Sorting Signals; D011518:Proto-Oncogene Proteins; D051880:Receptors, Notch; D051155:Wnt1 Protein; C074622:wg protein, Drosophila