[Development of a test system for detection of anti-endotoxic immunity in young children, healthy donors and some groups of therapeutic patients].
The content of antibodies to soluble lipid A detritus was studied with the use of the enzyme immunoassay techniques. Some regularities of anti-endotoxic immunity were established: the elevated level of anti-lipid A antibodies in chronic bronchial tree diseases of bacterial etiology. On the other hand, cases of severe purulent septic infections in young children were found to be accompanied by a considerable decrease in the titer of anti-endotoxic antibodies. The approaches to the therapy of diseases caused by Gram-negative bacteria by means of specific immunoglobulins are discussed.
Uvitskiĭ
A Iu
AIu
Medical Academy, Perm, Russia.
Pagnueva
L Iu
LIu
Popova
E D
ED
Khasanova
R B
RB
D000907:Antibodies, Bacterial / Q000097:blood*; D001424:Bacterial Infections / Q000276:immunology; D001982:Bronchial Diseases / Q000276:immunology; D004731:Endotoxins / Q000276:immunology*; D006801:Humans; D007109:Immunity / Q000502:physiology*; D007124:Immunoenzyme Techniques; D007223:Infant; D007231:Infant, Newborn; D008050:Lipid A / Q000276:immunology*; D008070:Lipopolysaccharides / Q000302:isolation & purification*; D012016:Reference Values; D012995:Solubility
D000907:Antibodies, Bacterial; D004731:Endotoxins; D008050:Lipid A; D008070:Lipopolysaccharides
Razrabotka test-sistemy dlia detektsii antiéndotoksicheskogo immuniteta u deteĭ rannego vozrasta, zdorovykh donorov i nekotorykh grupp terapevticheskikh bol'nykh.