Tigloylcholine: a new choline ester toxin from the hypobranchial gland of two species of muricid gastropods (Thais clavigera and Thais bronni).
Crude extracts from hypobranchial glands of two species of muricid gastropods, Thais clavigera and Thais bronni, were highly lethal to mice. Regardless of species, a new choline ester was isolated as the major toxic principle and elucidated to be tigloylcholine, a structural isomer of senecioylcholine widely found in gastropod hypobranchial glands, by 1H- and 13C-NMR as well as FAB-MS. The i.v. LD50 (mouse) of tigloylcholine was estimated to be 0.92 mg/kg.
Shiomi
K
K
Department of Food Science and Technology, Tokyo University of Fisheries, Japan.
Ishii
M
M
Shimakura
K
K
Nagashima
Y
Y
Chino
M
M
D000818:Animals; D002794:Choline / Q000031:analogs & derivatives* / Q000737:chemistry / Q000633:toxicity; D002855:Chromatography, Thin Layer; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008978:Mollusk Venoms / Q000737:chemistry / Q000633:toxicity*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013237:Stereoisomerism
D008978:Mollusk Venoms; C000840:senecioylcholine; D002794:Choline