Antimicrobial activity of a compound isolated from an oil-macerated garlic extract.
A compound showing antimicrobial activity was isolated from an oil-macerated garlic extract by silica gel column chromatography and preparative TLC. On basis of the results of NMR and MS analyses, it was identified as Z-4,5,9-trithiadeca-1,6-diene-9-oxide (Z-10-devinylajoene; Z-10-DA). Z-10-DA exhibited a broad spectrum of antimicrobial activity against such microorganisms as gram-positive and gram-negative bacteria and yeasts. The antimicrobial activity of Z-10-DA was comparable to that of Z-ajoene, but was superior to that of E-ajoene. Z-10-DA and Z-ajoene are different in respect of substitution of the allyl group by the methyl group flanking a sulfinyl group. This result suggests that substitution by the methyl group would also be effective for the inhibition of microbial growth.
Yoshida
H
H
Biodevelopment Division, Central Institute, Nagoya Seiraku Co., Ltd., Aichi, Japan.
Iwata
N
N
Katsuzaki
H
H
Naganawa
R
R
Ishikawa
K
K
Fukuda
H
H
Fujino
T
T
Suzuki
A
A
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D004220:Disulfides / Q000737:chemistry*; D005737:Garlic / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry*; D010938:Plant Oils / Q000737:chemistry*; D010946:Plants, Medicinal; D013329:Structure-Activity Relationship; D013454:Sulfoxides
D000900:Anti-Bacterial Agents; D004220:Disulfides; D010936:Plant Extracts; D010938:Plant Oils; D013454:Sulfoxides; C048980:ajoene