Use of quantitative trait loci to map murine lung tumor susceptibility genes.
During the last decade new methods for mapping quantitative trait loci (QTLs) have helped geneticists uncover disease-associated genes. Genetic dissection of complex multigenic diseases such as cancer is being accomplished in part by mapping QTLs in experimental crosses of mice [1]. With the recent construction of dense genetic linkage maps for the mouse, mapping of quantitative trait loci has become practical [2]. Over 6000 polymorphic simple sequence length repeat markers (microsatellite markers) have been mapped in the mouse genome [3], and new analytical approaches to linkage analysis have made QTL mapping a powerful technique for identifying cancer genes [4-7]. In this overview we discuss the design of QTL mapping studies and some of the findings from studies on the mapping of murine lung tumor susceptibility loci.
Devereux
T R
TR
Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. devereux@niehs.nih.gov
Kaplan
N L
NL
D000818:Animals; D002874:Chromosome Mapping; D004273:DNA, Neoplasm / Q000032:analysis*; D004195:Disease Models, Animal; D015972:Gene Expression Regulation, Neoplastic; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D007178:Inbreeding; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D018895:Microsatellite Repeats; D019655:Quantitative Trait, Heritable
D004273:DNA, Neoplasm