title: Initially unresectable hilar cholangiocarcinoma: hepatic regeneration after transarterial embolization.
abstract: OBJECTIVE
  To assess with volumetric computed tomography (CT) the pattern and extent of hepatic regeneration induced with transarterial embolization of initially unresectable hilar cholangiocarcinoma (Klatskin tumor).
  
  
  METHODS
  In this prospective study, 13 patients (four men, nine women) with hilar cholangiocarcinoma, aged 43-74 years (mean +/- 1 standard deviation, 59.9 years +/- 9.6), underwent preoperative embolization of the right hepatic lobe. Embolization was performed transarterially by using four to 15 embolization coils. Volumetric measurements of the entire liver, left hepatic lobe, and spleen were performed with contrast material-enhanced and unenhanced helical CT before and after embolization in all patients.
  
  
  RESULTS
  After right lobe embolization, volumetric helical CT measurements revealed a 2%-33% decrease (mean, 10%) in the volume of the affected right hepatic lobe, an 11%-68% increase (mean, 37%) in the volume of left hepatic lobe parenchyma, and variations in splenic volume of -5% to +28% (mean, +11%). Nine patients underwent extended hepatectomy 27-75 days (mean, 44 days) after embolization. No patient had severe complications due to embolization.
  
  
  CONCLUSIONS
  In patients with an initially unresectable bilateral Klatskin tumor, right lobar arterial coil embolization results in enlargement of the left hepatic lobe (as verified with volumetric helical CT), thus allowing right hemihepatectomy.
authors.affiliation: Department of Radiology, University Hospital Charité, Germany.
authors.forename: T J
authors.initials: TJ
authors.lastname: Vogl
authors.forename: J O
authors.initials: JO
authors.lastname: Balzer
authors.forename: K
authors.initials: K
authors.lastname: Dette
authors.forename: R
authors.initials: R
authors.lastname: Hintze
authors.forename: W
authors.initials: W
authors.lastname: Pegios
authors.forename: J
authors.initials: J
authors.lastname: Mäurer
authors.forename: H
authors.initials: H
authors.lastname: Keck
authors.forename: P
authors.initials: P
authors.lastname: Neuhaus
authors.forename: R
authors.initials: R
authors.lastname: Felix
mesh_terms: D000328:Adult; D000368:Aged; D001650:Bile Duct Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery / Q000628:therapy*; D001653:Bile Ducts, Intrahepatic / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D018281:Cholangiocarcinoma / Q000000981:diagnostic imaging / Q000601:surgery / Q000628:therapy*; D002760:Cholangiopancreatography, Endoscopic Retrograde; D003287:Contrast Media; D004621:Embolization, Therapeutic / Q000295:instrumentation / Q000379:methods; D005260:Female; D006498:Hepatectomy; D006499:Hepatic Artery; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007472:Iohexol / Q000031:analogs & derivatives; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery / Q000628:therapy*; D008115:Liver Regeneration; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011856:Radiographic Image Enhancement; D013154:Spleen / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D007472:Iohexol; C038192:iopromide