Theonellapeptolide IIIe, a new cyclic peptolide from the New Zealand deep water sponge, Lamellomorpha strongylata.
The structure, stereochemistry, and conformation of theonellapeptolide IIIe (1), a new 36-membered ring cyclic peptolide from the New Zealand deep-water sponge Lamellomorpha strongylata, is described. The sequence of the cytotoxic peptolide was determined through a combination of NMR and MS-MS techniques and confirmed by X-ray crystal structure analysis, which, with chiral HPLC, established the absolute stereochemistry.
Li
S
S
Department of Chemistry, University of Canterbury, Christchurch, New Zealand.
Dumdei
E J
EJ
Blunt
J W
JW
Munro
M H
MH
Robinson
W T
WT
Pannell
L K
LK
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D008401:Gas Chromatography-Mass Spectrometry; D009520:New Zealand; D010456:Peptides, Cyclic / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D011487:Protein Conformation; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014961:X-Ray Diffraction
D000596:Amino Acids; D000970:Antineoplastic Agents; D010456:Peptides, Cyclic; C113214:theonellapeptolide IIIe