PET imaging studies in drug abuse.
In spite of the massive public health problem associated with drug abuse, effective treatments remain elusive. This is due in part to a relatively poor understanding of the neurochemical changes which drugs of abuse produce in the human brain and the relationship of these changes to the behavioral and addictive properties of drugs. With the development of modern imaging methods and a variety of labeled drugs and radiotracers, it has now become possible to track many aspects of drug pharmacokinetics and pharmacodynamics directly in the human brain and to relate these parameters to the behavioral and toxic properties of drugs.


METHODS
In this article, we will highlight some examples of the use of Positron Emission Tomography to measure drug pharmacokinetics and pharmacodynamics and their relationship to addiction and to toxicity.
Fowler
J S
JS
Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA. fowler@bnl.gov
Volkow
N D
ND
D001921:Brain / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D013287:Illicit Drugs / Q000493:pharmacokinetics / Q000494:pharmacology; D015813:Substance Abuse Detection; D019966:Substance-Related Disorders / Q000000981:diagnostic imaging*; D014055:Tomography, Emission-Computed
D013287:Illicit Drugs