Stability of adenosine in infusion.
Using liquid chromatography the stability of adenosine in aqueous solution was investigated at five different temperatures, namely 4, 22, 37, 60 and 72 degrees C over a period of 6 months. At the three lowest temperatures, the initial concentration of the product was not altered, at the highest temperatures there was a significant decrease. From these data the shelf life (t90) at room temperature was estimated to be at least 5 years.
Proot
P
P
UZ Gasthuisberg Apotheek, Leuven, Belgium.
Van Schepdael
A
A
Raymakers
A A
AA
Hoogmartens
J
J
D000241:Adenosine / Q000032:analysis / Q000737:chemistry*; D002853:Chromatography, Liquid; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D012996:Solutions; D013696:Temperature; D013997:Time Factors
D012996:Solutions; D000241:Adenosine