title: Salivary gland carcinomas: prognostic significance of simple mucin-type carbohydrate antigens.
abstract: The prognosis of salivary gland carcinomas is difficult to assess. Simple mucin-type carbohydrates (T and sialosyl-T antigens, Tn and sialosyl-Tn antigens) have been shown to be of value in predicting prognosis for carcinomas in other locations. We studied the prognostic significance of the expression of these structures in a retrospective study of 133 patients with salivary gland carcinomas, using immunohistochemistry and a panel of well-defined monoclonal antibodies (MAbs) on formalin-fixed paraffin-embedded tissues. Sialosyl-Tn, T and sialosyl-T antigens were not correlated with prognosis. Univariate analyses showed no overall difference in survival or locoregional control between patients with Tn-positive and patients with Tn-negative tumours, but indicated that expression of the Tn antigen was associated with early locoregional recurrences and deaths. Tn was, however, not an independent prognostic factor by multivariate regression analysis.
authors.affiliation: Department of Pathology, Rigshospitalet, National University Hospital, Copenhagen, Denmark.
authors.forename: M H
authors.initials: MH
authors.lastname: Therkildsen
authors.forename: L J
authors.initials: LJ
authors.lastname: Andersen
authors.forename: M
authors.initials: M
authors.lastname: Christensen
authors.forename: H S
authors.initials: HS
authors.lastname: Hansen
authors.forename: T
authors.initials: T
authors.lastname: Schiødt
authors.forename: E
authors.initials: E
authors.lastname: Dabelsteen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009077:Mucins / Q000032:analysis*; D011379:Prognosis; D012468:Salivary Gland Neoplasms / Q000737:chemistry* / Q000473:pathology; D015996:Survival Rate
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D009077:Mucins; C040286:Tn antigen; C087769:sialosyl-T antigen; C055491:sialosyl-Tn antigen; C016467:Thomsen-Friedenreich antigen