title: Proteasome assembly: biting the hand.
abstract: Proteasome assembly is regulated to ensure the enzyme is inactive until its active sites are compartmentalized within an interior aqueous chamber. In yeast, this depends on a dedicated chaperone that is trapped within the nascent proteasome, and degraded on maturation of the proteolytic subunits.
authors.affiliation: Laboratory of Cell Biology, National Cancer Institute, Bethesda, Maryland 20892, USA. mmaurizi@helix.nih.gov
authors.forename: M R
authors.initials: MR
authors.lastname: Maurizi
mesh_terms: D000818:Animals; D003546:Cysteine Endopeptidases / Q000737:chemistry* / Q000378:metabolism*; D019281:Dimerization; D006801:Humans; D008954:Models, Biological; D018832:Molecular Chaperones / Q000378:metabolism / Q000502:physiology; D009097:Multienzyme Complexes / Q000737:chemistry* / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex; D017510:Protein Folding
chemical_list: D018832:Molecular Chaperones; D009097:Multienzyme Complexes; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex