Plasma-pooling methods to increase throughput for in vivo pharmacokinetic screening.
Hop
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CE
Department of Drug Metabolism, Merck Research Laboratories, Mail Code: RY80L-109, PO Box 2000, Rahway, New Jersey 07065-0900, USA. corenelis_hop@merck.com
Wang
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Z
Chen
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Kwei
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D000818:Animals; D019540:Area Under Curve; D001774:Blood Chemical Analysis / Q000379:methods*; D002853:Chromatography, Liquid; D004285:Dogs; D004353:Drug Evaluation, Preclinical / Q000379:methods; D013058:Mass Spectrometry; D010599:Pharmacokinetics; D013997:Time Factors