Skin-sparing mastectomy and immediate reconstruction: oncologic risks and aesthetic results in patients with early-stage breast cancer.
Skin-sparing mastectomy has been advocated as an oncologically safe approach for the management of patients with early-stage breast cancer that minimizes deformity and improves cosmesis through preservation of the skin envelope of the breast. Because chest wall skin is the most frequent site of local failure after mastectomy, concerns have been raised that inadequate skin excision could result in an increased risk of local recurrence. Precise borders of the skin resection have not been well established, and long-term local recurrence rates after skin-sparing mastectomy are not known. The purpose of this study was to evaluate the oncologic safety and aesthetic results for skin-sparing mastectomy and immediate breast reconstruction with a latissimus dorsi myocutaneous flap and saline breast prosthesis. Fifty-one patients with early-stage breast cancer (26 with ductal carcinoma in situ and 25 with invasive carcinoma) undergoing primary mastectomy and immediate reconstruction with a latissimus flap were studied from 1991 through 1994. For 32 consecutive patients, skin-sparing mastectomy was defined as a 5-mm margin of skin designed around the border of the nipple-areolar complex. After the mastectomy, biopsies were obtained from the remaining native skin flap edges. Patients were followed for 44.8 months. Histologic examination of 114 native skin flap biopsy specimens failed to demonstrate breast ducts in the dermis of any of the 32 consecutive patients studied. One of 26 patients with ductal carcinoma in situ had metastases to the skin of the lateral chest wall and back. Four other patients, one with stage I disease and three with stage II-B disease, had recurrent breast carcinoma. The stage I patient had a local recurrence in the subcutaneous tissues near the mastectomy specimen. Two patients suffered axillary relapse, and one had distant metastases to the spine. The findings of this study support the technique of skin-sparing mastectomy as an oncologically safe one, based on an absence of breast ductal epithelium at the margins of the native skin flaps and a local recurrence rate of 2 percent after 45 months of follow-up. Although these results need to be confirmed with greater numbers of patients and longer follow-up, skin-sparing mastectomy and immediate breast reconstruction may be considered an excellent alternative treatment to breast conservation for patients with ductal carcinoma in situ and early-stage invasive breast cancer.
Slavin
S A
SA
Department of Surgery, Beth Israel-Deaconess Medical Center, and Harvard Medical School, Boston, Mass, USA.
Schnitt
S J
SJ
Duda
R B
RB
Houlihan
M J
MJ
Koufman
C N
CN
Morris
D J
DJ
Troyan
S L
SL
Goldwyn
R M
RM
D000328:Adult; D001706:Biopsy; D018427:Breast Implants; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery*; D002277:Carcinoma / Q000473:pathology / Q000601:surgery; D002278:Carcinoma in Situ / Q000556:secondary / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000556:secondary / Q000601:surgery; D062109:Dermatologic Surgical Procedures; D004954:Esthetics; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology; D016462:Mammaplasty / Q000379:methods*; D008408:Mastectomy / Q000379:methods*; D018482:Muscle, Skeletal / Q000637:transplantation; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009367:Neoplasm Staging; D009558:Nipples / Q000601:surgery; D012307:Risk Factors; D012449:Safety; D012878:Skin Neoplasms / Q000556:secondary; D016038:Skin Transplantation; D012965:Sodium Chloride; D013125:Spinal Neoplasms / Q000556:secondary; D013524:Surgical Flaps
D012965:Sodium Chloride