Identification of the sensory/motor area and pathologic regions using ECoG coherence.
An electrophysiologic mapping technique which enables identification of the central sulcus and pathologic cortical regions is described. Electrocorticographic recordings of 1 min duration were recorded from 25 patients who were undergoing resection of tumors in the sensory-motor region or being evaluated for temporal lobectomy for epilepsy. Analysis of the patterns of subdural inter-electrode coherence revealed low coherence across the central sulcus for 11/12 cases where its location could be verified with direct cortical stimulation and/or somatosensory evoked potential mapping. Regions of high coherence identified the location of tumors in the sensory-motor region for 10/10 cases. Over the temporal lobe, localized areas of high coherence were evident in 8/9 epilepsy patients, but were not indicative of the location of mesial temporal lobe tumors or inter-ictal spiking, when present. We conclude that analysis of cortical coherence patterns may be helpful for revealing the location of pathologic processes relative to critical cortical areas.
Towle
V L
VL
Department of Neurology, The University of Chicago, Illinois 60637, USA. v-towle@uchicago.edu
Syed
I
I
Berger
C
C
Grzesczcuk
R
R
Milton
J
J
Erickson
R K
RK
Cogen
P
P
Berkson
E
E
Spire
J P
JP
D000293:Adolescent; D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D001927:Brain Diseases / Q000175:diagnosis* / Q000503:physiopathology; D001931:Brain Mapping; D001932:Brain Neoplasms / Q000175:diagnosis / Q000503:physiopathology; D002540:Cerebral Cortex / Q000503:physiopathology*; D002648:Child; D004569:Electroencephalography; D004827:Epilepsy / Q000175:diagnosis / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology*; D012677:Sensation / Q000502:physiology*