Evolution by fusion and amplification: the murine Sp100-rs gene cluster.
Sp100 is a single-copy gene in the human and the mouse. A related gene, Sp100-rs, occurs in multiple copies and forms a conspicuous cluster in the mouse chromosome 1. Murine Sp100 and Sp100-rs are homologous from the promoter up to a position in intron 3, but they differ 3' of that position. In the genus Mus, Sp100-rs is present in one phylogenetic branch, represented by the house mouse, M. musculus, but probably does not exist in another branch, represented by M. caroli. Thus, Sp100-rs arose relatively late in the evolution of the genus Mus, whereas Sp100 existed in the common ancestor of the human and the mouse. The Sp100-rs gene cluster probably evolved by gene fusion followed by amplification and diversification.
Institut für Biologie, Medizinische Universität zu Lübeck, Germany.
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Weichenhan
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Kunze
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Winking
D000818:Animals; D034961:Antigens, Nuclear; D019677:Artificial Gene Fusion; D001324:Autoantigens / Q000235:genetics*; D001483:Base Sequence; D017124:Conserved Sequence; D018076:DNA, Complementary; D019143:Evolution, Molecular; D005784:Gene Amplification; D018628:Gene Dosage; D007438:Introns; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D005810:Multigene Family; D009687:Nuclear Proteins / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
D034961:Antigens, Nuclear; D001324:Autoantigens; D018076:DNA, Complementary; D009687:Nuclear Proteins; C066642:SP100 protein, human