Elevated numbers of reticulated platelets in hyperthyroidism: direct evidence for an increase of thrombopoiesis.
We studied thrombopoietic activity in hyperthyroidism by determination of reticulated platelet counts. At the time of hyperthyroidism 14/15 patients had higher reticulated platelets than after achievement of euthyroidism (P<0.001). There was no difference in peripheral platelet counts and mean platelet volumes at the time of hyperthyroidism when compared to euthyroidism. Three patients had pan- and auto-reactive platelet antibodies during hyperthyroidism. These antibodies were directed against GPIIb/IIIa in two patients and against GPIb/IX in one patient. Our findings provide direct evidence that hyperthyroidism is associated with increased platelet production, as reflected by an increase in reticulated platelets.
Stiegler
G
G
Clinic for Blood Group Serology and Transfusion Medicine, University of Vienna, Austria.
Stohlawetz
P
P
Brugger
S
S
Jilma
B
B
Vierhapper
H
H
Höcker
P
P
Panzer
S
S
D000328:Adult; D000368:Aged; D000906:Antibodies / Q000032:analysis; D001792:Blood Platelets / Q000473:pathology*; D005260:Female; D006410:Hematopoiesis; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000276:immunology; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000276:immunology; D013922:Thrombocytosis / Q000209:etiology* / Q000473:pathology
D000906:Antibodies; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D019038:Platelet Glycoprotein GPIb-IX Complex