Parasitized female mice display reduced aversive responses to the odours of infected males.
The present study showed that parasites influence both the responses of uninfected females to males and the responses of female hosts to infected males. In female laboratory mice one of the consequences of exposure to the olfactory cues associated with an infected male was a reduction of the reactivity to a thermal surface, i.e. pain inhibition or analgaesia. Uninfected oestrous and non-oestrous female mice displayed marked analgaesic responses after exposure to the odours of males infected with either the enteric single-host nematode parasite, Heligmosomoides polygyrus, or the protozoan parasite, Eimeria vermiformis. The uninfected oestrous females distinguished between infected and physically stressed males, displaying a greater analgaesic response to the odours of infected males. These analgaesic responses and their anxiety/ fearfulness-associated behavioural correlates could elicit either a reduced interest in, or avoidance of, parasitized males by females. Oestrous female mice infected with H. polygyrus displayed a reduced analgaesic response to the odours of the infected males and differentially responded to the odours of males infected with either the same (H. polygyrus) or a different parasite (E. vermiformis). An exposure time of 1 min elicited minimal responses to the odours of males infected with the same parasite, H. polygyrus, and an attenuated, though significant, non-opioid peptide-mediated analgaesic response to males infected with E. vermiformis. An exposure time of 30 min elicited similar markedly reduced endogenous opioid peptide-mediated analgaesic responses to the odours of both of the categories of infected males. The responses to the odours of a stressed male were, however, unaffected by the parasitic infection. The reduced analgaesic responses of the parasitized females to the odours of infected males may involve either enhanced odour familiarity and responses to group odour templates and/or neuromodulatory shifts resulting in reduced fearfulness and potentially greater interest in the infected males.
Kavaliers
M
M
Department of Psychology, University of Western Ontario, London, Canada. kavalier@julian.uwo.ca
Colwell
D D
DD
Choleris
E
E
D000818:Animals; D003048:Coccidiosis / Q000469:parasitology / Q000503:physiopathology*; D004539:Eimeria / Q000502:physiology*; D004971:Estrus; D005260:Female; D006790:Host-Parasite Interactions; D008297:Male; D051379:Mice; D009351:Nematospiroides dubius / Q000502:physiology*; D009812:Odorants; D010146:Pain; D012726:Sexual Behavior, Animal; D017206:Strongylida Infections / Q000469:parasitology / Q000503:physiopathology*