A comparison of the efficacy of new asymmetric bispyridinium oxime BI-6 with other oximes (obidoxime, HI-6) against soman in rats.
1. The influence of three oximes (obidoxime, HI-6 and the new asymmetric bispyridinium oxime BI-6) in combination with atropine on soman-induced cholinergic and stressogenic effects in rats was studied. 2. The oxime BI-6 produced significantly higher reactivation of soman-inhibited blood and diaphragm cholinesterases than obidoxime. On the other hand, its reactivating effect was not so high as the effect of the oxime HI-6. 3. There were not significant differences in the reactivation of soman-inhibited brain acetylcholinesterase among all three oximes tested. 4. The influence of the oxime BI-6 on soman-induced stressogenic effects was greater than the antistressogenic effects of HI-6 or obidoxime at 1 h or 3 h following soman poisoning. 5 These findings confirm that the oxime BI-6 has no definite advantages over HI-6 in the antidotal treatment of soman poisoning but BI-6 is significantly more effective in rats than obidoxime, one of the oximes presently in use.
Kassa
J
J
Purkyne Military Medical Academy, Hradec Králové, Czech Republic.
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D001285:Atropine / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002801:Cholinesterase Reactivators / Q000627:therapeutic use*; D002802:Cholinesterases / Q000097:blood; D003964:Diaphragm / Q000187:drug effects / Q000201:enzymology; D004359:Drug Therapy, Combination; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D009768:Obidoxime Chloride / Q000627:therapeutic use*; D010091:Oximes / Q000627:therapeutic use*; D011041:Poisoning / Q000188:drug therapy*; D011725:Pyridines / Q000627:therapeutic use*; D011726:Pyridinium Compounds / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012999:Soman / Q000506:poisoning*; D014444:Tyrosine Transaminase / Q000378:metabolism
D000931:Antidotes; C114515:BI-6, bispyridinium oxime; D002801:Cholinesterase Reactivators; D010091:Oximes; D011725:Pyridines; D011726:Pyridinium Compounds; D009768:Obidoxime Chloride; D001285:Atropine; D012999:Soman; D014444:Tyrosine Transaminase; D000110:Acetylcholinesterase; D002802:Cholinesterases; C022870:asoxime chloride