Functional characterization of cardiac myosin isoforms.
In this brief review, we have discussed the functional significance of cardiac myosin isoform redistribution. The development of in vitro motility assay techniques has greatly aided the research in this field. The next important step would be the integration of data at molecular or cellular level to account for the pathophysiology of animal or human body. A new conceptual framework that can deal with the complex nature of a biological system may be required for this purpose.
The Second Department of Internal Medicine, School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan.
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Sugiura
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Yamashita
D000818:Animals; D004734:Energy Metabolism; D005786:Gene Expression Regulation / Q000235:genetics; D006801:Humans; D009200:Myocardial Contraction / Q000502:physiology; D009206:Myocardium / Q000378:metabolism*; D018995:Myosin Heavy Chains / Q000235:genetics / Q000378:metabolism; D009218:Myosins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology*
D018995:Myosin Heavy Chains; D009218:Myosins