Effects of La3+ on lipid fluidity and structural transitions in human erythrocyte membranes.
The effects of La3+ on the structure and function of human erythrocyte membranes were investigated by fluorescence polarization, spin-labeled electron spin resonance (ESR) and differential scanning calorimetry (DSC). The results showed that increasing concentrations of La3+ inhibited (Na(+) + K+)-ATPase and Mg(2+)-ATPase activities. La3+ lowered the lipid fluidity of erythrocyte membranes and induced structural transitions in erythrocyte membranes.
Li
X M
XM
Laboratory of Rare Earth Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, China.
Ni
J Z
JZ
Chen
J W
JW
Hwang
F
F
D017301:Ca(2+) Mg(2+)-ATPase / Q000037:antagonists & inhibitors*; D002152:Calorimetry, Differential Scanning; D004578:Electron Spin Resonance Spectroscopy; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D006801:Humans; D007811:Lanthanum / Q000494:pharmacology*; D008560:Membrane Fluidity / Q000187:drug effects*; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*; D013050:Spectrometry, Fluorescence
D007811:Lanthanum; D017301:Ca(2+) Mg(2+)-ATPase; D000254:Sodium-Potassium-Exchanging ATPase