Hematoporphyrin derivative or phthalocyanine photosensitized hemolysis of erythrocytes under laser irradiation.
The effect of laser irradiation on the photosensitized hemolysis of rabbit erythrocytes was investigated. Two photosensitizers of domestic production were used: Photohem (a hematoporphyrin derivative) and Photosense (sulfonated phthalocyanine aluminium). The hemolysis was activated by laser irradiation in the presence of Photohem or Photosense. The process depended on the irradiation dose, the concentration of the photosensitizers and on the time during which the erythrocytes were incubated with the photosensitizers. Three lasers with wavelengths 520, 632.8 and 850 nm were used. The photosensitized hemolysis of rabbit erythrocytes was found to be inhibited by antioxidants.
Russian State Medical University, Moscow, Russia. gavlad@fbm.msu.ru
G I
GI
Klebanov
T V
TV
Chichuk
L N
LN
Shutova
E F
EF
Stranadko
Vladimirov YuA
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D004912:Erythrocytes / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D017324:Hematoporphyrin Derivative / Q000494:pharmacology*; D006461:Hemolysis / Q000187:drug effects* / Q000528:radiation effects; D007211:Indoles / Q000494:pharmacology*; D054833:Isoindoles; D007700:Kinetics; D007834:Lasers; D017319:Photosensitizing Agents / Q000494:pharmacology*; D011817:Rabbits
D007211:Indoles; D054833:Isoindoles; D017319:Photosensitizing Agents; D017324:Hematoporphyrin Derivative; C013647:phthalocyanine