The effect of the sulfonylurea glyburide on nitric oxide in streptozotocin-induced diabetic rat.
1. The interaction between nitric oxide (NO) and superoxide anions has received a great deal of attention. Because NO is rapidly inactivated by superoxide anions, it has been suggested that an enhanced formation of this radical may be involved in the accelerated breakdown of NO. 2. In the present study, we administrated glyburide (glibenclamide) to Streptozotocin-induced diabetic rats and determined the effect of such treatment on serum nitrite+nitrate levels. Serum nitrite+nitrate levels were reduced in diabetic animals (P<0.001). Administration of glyburide to diabetic rats reversed the diabetes-induced changes, suggesting that glyburide may directly increase serum nitrite+nitrate levels.
Altan
N
N
Department of Biochemistry, Faculty of Medicine, University of Gazi, Ankara, Turkey.
Buğdayci
G
G
Tutkun
F K
FK
Sancak
B
B
Nazaroğlu
N K
NK
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism; D005905:Glyburide / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D051381:Rats
D007004:Hypoglycemic Agents; D009569:Nitric Oxide; D005905:Glyburide