[The role of polyol pathways in formation of diabetic cataracts].
The authors present current knowledge concerning the role of polyols in the formation of cataract in diabetic patients. Sugar alcohols are formed in lens as a consequence of glucose conversion in the sorbitol pathway. The pharmacological modulation of this process by the application of aldose reductase inhibitors are also discussed.
Katedry i Kliniki Okulistyki AM w Białymstoku.
K
K
Sabasiński
J
J
Andrzejewska-Buczko
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors; D000818:Animals; D002386:Cataract / Q000209:etiology* / Q000378:metabolism / Q000517:prevention & control; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007908:Lens, Crystalline / Q000378:metabolism; D011108:Polymers / Q000378:metabolism*; D013012:Sorbitol / Q000378:metabolism*
D011108:Polymers; C024617:polyol; D013012:Sorbitol; D000449:Aldehyde Reductase; D005947:Glucose