Receptor-mediated local fine-tuning by noradrenergic innervation of neuroendocrine and immune systems.
Immune responses can be modulated by noradrenergic input at (1) hypothalamic (CRF and ACTH release), (2) immune cell (cytokine production), and (3) adrenal cortex (glucocorticoid production) level. Elucitating the basic mechanisms responsible for immunological responses and diseases may be helpful in developing therapeutic approaches for many disorders, such as autoimmune diseases.
Department of Pharmacology, Hungarian Academy of Sciences, Budapest, Hungary. esvizi@koki.hu
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D000302:Adrenal Cortex / Q000502:physiology; D000324:Adrenocorticotropic Hormone / Q000502:physiology; D003346:Corticotropin-Releasing Hormone / Q000502:physiology; D016207:Cytokines / Q000502:physiology; D005938:Glucocorticoids / Q000502:physiology; D007031:Hypothalamus / Q000502:physiology; D007107:Immune System / Q000502:physiology*; D009490:Neurosecretory Systems / Q000502:physiology*; D009638:Norepinephrine / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000502:physiology
D016207:Cytokines; D005938:Glucocorticoids; D011941:Receptors, Adrenergic; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D009638:Norepinephrine