Detecting experimental liver metastases at CT with the hepatocyte-specific contrast medium FP 736-03.
OBJECTIVE
To evaluate the detection of experimental hepatic metastases at CT with the hepatocyte-specific contrast medium FP 736-03.


METHODS
A nude-rat model of experimental multiple hepatic metastases from a human colonic cancer was used. Three weeks after intraportal tumour cell injection, the CT examination was performed before and after i.v. injection of FP 736-03 at a dose of 0.5 ml/kg b.w.


RESULTS
The overall detection rate was determined in a lesion-by-lesion analysis of 87 metastases. Irrespective of metastatic size, the mean detection rate for two viewers was significantly higher at the FP-736-03-enhanced examination (59%) than at the unenhanced CT examination (16%).


CONCLUSIONS
The detection rate increased with the i.v. administration of FP 736-03 at a dose of 0.5 ml/kg b.w. compared with that at unenhanced examination.
Bergman
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Department of Diagnostic Radiology, University Hospital, Uppsala, Sweden.
Magnusson
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Sundin
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D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000556:secondary*; D000818:Animals; D002784:Cholesterol; D003287:Contrast Media; D004353:Drug Evaluation, Preclinical; D004655:Emulsions; D005217:Fat Emulsions, Intravenous; D007459:Iodized Oil; D008099:Liver / Q000000981:diagnostic imaging*; D008114:Liver Neoplasms, Experimental / Q000000981:diagnostic imaging* / Q000556:secondary*; D009368:Neoplasm Transplantation; D015588:Observer Variation; D010743:Phospholipids; D051381:Rats; D011923:Rats, Nude; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014407:Tumor Cells, Cultured
D003287:Contrast Media; D004655:Emulsions; D005217:Fat Emulsions, Intravenous; D010743:Phospholipids; C092563:iodized oil, phospholipid, cholesterol emulsion; D007459:Iodized Oil; D002784:Cholesterol