Efficacy of difloxacin in growing broiler chickens for the control of infection due to pathogenic Mycoplasma gallisepticum.
Chickens 14 days old were experimentally inoculated with Mycoplasma gallisepticum (MG) R-P10 strain. After development of respiratory symptoms, birds were left unmedicated or medicated for 5 consecutive days with Difloxacin 5, 7.5 or 10 mg/kg body weight per day or Enrofloxacin at the dose level of 10 mg/kg body weight per day. Evaluation of efficacy was based on body weight, symptoms, post-mortem findings, re-isolation of MG and serology. Results indicated that under the conditions of this experiment, treatment with 7.5 mg Difloxacin per kg body weight for 5 days was already effective against pathogenic MG infection. The dose of 10 mg/kg Difloxacin was equally effective as a dose of 10 mg/kg Enrofloxacin in treating respiratory symptoms.
CNEVA Ploufragan, Mycoplasmology and Bacteriology Unit, Zoopole, France.
I
I
Kempf
R
R
van den Hoven
F
F
Gesbert
M
M
Guittet
D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002645:Chickens; D002939:Ciprofloxacin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000077422:Enrofloxacin; D005260:Female; D024841:Fluoroquinolones; D008297:Male; D009174:Mycoplasma / Q000302:isolation & purification; D009175:Mycoplasma Infections / Q000517:prevention & control / Q000662:veterinary*; D011201:Poultry Diseases / Q000517:prevention & control*; D015363:Quinolones / Q000627:therapeutic use
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; D000077422:Enrofloxacin; D002939:Ciprofloxacin; C047225:difloxacin