Non-coding DNA can regulate gene transcription by its base pair's distribution.
In this paper we show that the gene transcription velocity can depend exponentially on the first moments of the base pair distribution in DNA. As the major fraction of the DNA of eucaryotes consists of non-coding sequences of base pairs and these determine the statistical characteristics of the base pair's ordering, non-coding DNA plays an important role in the functioning of the genetic apparatus. In particular, it enables a new independent mechanism for the gradual regulation of gene expression in eucaryotes.
Jerusalem College of Technology, Israel. SandlereMath.JCT.AC.IL
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Sandler
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Wyler
D000818:Animals; D004247:DNA / Q000235:genetics*; D005057:Eukaryotic Cells / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology; D008957:Models, Genetic; D014158:Transcription, Genetic
D004247:DNA