[Effects of sunscreening agents and reactions with ultraviolet radiation].
The use of sunscreens is extensive. During the last few years there have been indications that UV radiation causes breakdown of the sunlight absorbing filters in the sunscreens, i.e. the sunscreens are not photostable. We describe briefly UV propagation in skin, the chemical and physical properties of sunscreens, and how these may react during UV irradiation. We have studied the stability of several sunscreens in vitro. The stability tests were performed by applying a thin film of the sunscreen preparation to the wall of a quartz window, irradiating it with a sun simulator, and measuring the absorbance with spectrophotometry before and during irradiation. The sunscreen agent studied most thoroughly was the UVB filter octyl methoxy cinnamate, but other UVA and UVB filters and some commercial products were also tested. Considerable breakdown of most filters was observed after doses of irradiation equivalent to moderate sun exposure. It can be questioned whether the breakdown products of sunscreens also possess other physical or biological properties. General practitioners should be able to advise their patients on sun protection and the proper use of sunscreens, considering the extensive use of sunscreens and the fact that sunbathing may be a health hazard.
Statens strålevern, Osterås.
K
K
Bredholt
T
T
Christensen
M
M
Hannevik
B
B
Johnsen
J
J
Seim
J B
JB
Reitan
D002934:Cinnamates / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism; D004355:Drug Stability; D006801:Humans; D012307:Risk Factors; D012867:Skin / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D012869:Skin Absorption / Q000528:radiation effects*; D013473:Sunscreening Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D014466:Ultraviolet Rays
D002934:Cinnamates; D013473:Sunscreening Agents