In utero brain lesions in SIDS.
Serial examination of the cerebral hemispheres of 20 sudden infant death syndrome victims revealed high incidence of leukomalacia (40%), leptomeningeal glioneuronal heterotopias (70%) at the base of the cerebrum, and astrogliosis (65%) in the white matter and medulla reticular formation compared with 20 age-matched controls. These results suggest that an antepartum insult may become an important predisposing risk factor in some patients for sudden infant death syndrome.
Obonai
T
T
Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.
Takashima
S
S
D001921:Brain / Q000196:embryology / Q000473:pathology; D001927:Brain Diseases / Q000196:embryology / Q000473:pathology*; D002828:Choristoma / Q000196:embryology / Q000473:pathology*; D005260:Female; D005911:Gliosis / Q000196:embryology / Q000473:pathology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007969:Leukomalacia, Periventricular / Q000196:embryology / Q000473:pathology*; D008578:Meninges / Q000196:embryology / Q000473:pathology; D009457:Neuroglia; D009474:Neurons; D011247:Pregnancy; D012307:Risk Factors; D013398:Sudden Infant Death / Q000473:pathology*