Levels of soluble Fas ligand in myocarditis.
Serum levels of soluble Fas ligand (sFasL) increased with the severity of congestive heart failure (p <0.01), and the percentages of apoptotic myocytes detected by in situ DNA nick-end labeling were significantly higher in the patients with increased levels of sFasL than in those with normal levels of sFasL (p <0.05). These findings indicated that sFasL may play an important role in pathogenesis of myocarditis.
Toyozaki
T
T
Division of Pathology, Institute of Pulmonary Cancer Research, Chiba University School of Medicine, Japan.
Hiroe
M
M
Tanaka
M
M
Nagata
S
S
Ohwada
H
H
Marumo
F
F
D000328:Adult; D000954:Antigens, Surface / Q000097:blood*; D017209:Apoptosis; D004797:Enzyme-Linked Immunosorbent Assay; D053222:Fas Ligand Protein; D005260:Female; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood*; D009205:Myocarditis / Q000097:blood*
D000954:Antigens, Surface; C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins