Morphological findings in non-episode biopsies of kidney transplant allografts treated with FK506 or cyclosporine.
We conducted an analysis of biopsy specimens of non-episode renal allografts from patients treated with tacrolimus (FK506) or cyclosporine (CsA) to evaluate chronic drug-induced nephropathy in stable allografts. A total of 38 biopsy specimens from stable functioning renal allografts were examined. The patients had been treated with FK506 (n = 16) or CsA (n = 18) as main immunosuppressant for 0.3 to 7.4 years. Of the 38 biopsy specimens, 15 showed mild drug-induced arteriolopathy (hyalinosis or insudative change of arterioles and small arteries) with striped-form interstitial fibrosis, 10 showed minimum interstitial cellular infiltration (borderline rejection), 2 showed IgA nephropathy, 4 showed evidence of chronic rejection (transplant nephropathy) and 12 showed no abnormal findings. Of 34 renal allograft biopsy specimens with stable function, 22 (65%) showed pathological evidence of drug-induced nephropathy. There were no significant qualitative or quantitative differences between FK506- and CsA-associated nephropathy.
Kyo
M
M
Sakurabashi Circulate Organ Clinic 1100, Osaka, Japan.
Hatori
M
M
Takahara
S
S
Kyakuno
M
M
Nakamura
T
T
Okada
M
M
Kokado
Y
Y
Toki
K
K
Ding
X Q
XQ
Miki
T
T
Miyamoto
M
M
Okuyama
A
A
D001706:Biopsy; D016572:Cyclosporine / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007668:Kidney / Q000098:blood supply / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced* / Q000473:pathology*; D016030:Kidney Transplantation / Q000473:pathology*; D011183:Postoperative Complications / Q000139:chemically induced* / Q000473:pathology*; D016559:Tacrolimus / Q000009:adverse effects*; D014652:Vascular Diseases / Q000139:chemically induced / Q000473:pathology
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D016559:Tacrolimus