Edible vaccines.
The ultimate vaccine is an oral vaccine which given once protects against a multitude of diseases. Furthermore this ultimate vaccine needs to be very stable and inexpensive to produce. Probably this latter condition can be met only if the vaccines are produced in plants. Such vaccines are called 'edible vaccines'. Edible vaccines can be produced in plants in many ways. Using recombinant plantvirus, CPMV, it was shown that plants can produce massive amounts of chimaeric virus particles which protect after a single injection the target animal against disease. The final step, oral administration, is being addressed at present. Preliminary experiments by others suggest that this step may be solved sooner than expected.
Meloen
R H
RH
ID-DLO, Lelystad, The Netherlands.
Hamilton
W D
WD
Casal
J I
JI
Dalsgaard
K
K
Langeveld
J P
JP
D000595:Amino Acid Sequence; D000818:Animals; D000956:Antigens, Viral / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D002213:Capsid / Q000737:chemistry / Q000276:immunology; D017798:Comovirus / Q000235:genetics / Q000276:immunology; D004283:Dog Diseases / Q000517:prevention & control; D004285:Dogs; D028301:Feline Panleukopenia Virus / Q000235:genetics / Q000276:immunology; D005818:Genetic Engineering; D006801:Humans; D008907:Mink; D008969:Molecular Sequence Data; D010322:Parvoviridae Infections / Q000517:prevention & control / Q000662:veterinary; D017993:Parvovirus, Canine / Q000235:genetics / Q000276:immunology; D010945:Plants, Edible / Q000276:immunology*; D030821:Plants, Genetically Modified / Q000276:immunology; D014611:Vaccination / Q000639:trends*; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000592:standards*
D000956:Antigens, Viral; D014614:Vaccines, Synthetic