Functional significance of the 10 Hz rhythmic discharges in sympathetic nerves.
1. By measuring renal vascular conductance in anaesthetized and immobilized rabbits, the functional significance of the 10 Hz rhythmic discharges in the sympathetic nerves was assessed by electrical stimulation of the renal nerve. This stimulation mimicked the intermittently occurring 10 Hz rhythmic discharges. 2. Comparison of high-frequency (10-20 Hz) intermittent electrical stimulation with continuous low-frequency (5 Hz) stimulation showed that the intermittent high-frequency stimulation evoked faster (smaller time constant) and larger responses of the renal vascular conductance if the total number of stimulus pulses was the same. 3. Therefore, the intermittently occurring 10 Hz rhythmic discharges in the sympathetic nerve produces faster and larger effects on peripheral organs than effects produced by continuous discharges if the number of spikes is equal.
Kishi
E
E
Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki-ken, Japan.
Ootsuka
Y
Y
Rong
W
W
Terui
N
N
D000818:Animals; D004558:Electric Stimulation; D004594:Electrophysiology; D007668:Kidney / Q000294:innervation* / Q000502:physiology; D017078:Laser-Doppler Flowmetry; D011817:Rabbits; D012079:Renal Circulation / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology*; D014655:Vascular Resistance / Q000502:physiology