Muscle rigidity induced by fluphenazine in rats is antagonized by L-DOPA, an antiparkinsonian drug.
The aim of the present study was to find out whether the classic neuroleptic fluphenazine is a good model compound for inducing parkinsonian-like muscle rigidity in rats. The muscle tone was measured as resistance developed by the rat's hind foot to passive flexion and extension. Fluphenazine in doses of 0.4-3.0 mg/kg i.p. induced a dose-dependent increase in the hind foot resistance to passive movements. The muscle rigidity induced by fluphenazine 1.5 mg/kg i.p.) was counteracted in a dose-dependent manner by the main antiparkinsonian drug L-DOPA (25-75 mg/kg i.p.). The present results suggest that the fluphenazine-induced muscle rigidity may be a useful model of parkinsonian rigidity.
Department of Neuro-Psychopharmacology, Polish Academy of Sciences, Kraków, Poland.
K
K
Ossowska
J
J
Konieczny
E
E
Lorenc-Koci
G
G
Schulze
H
H
Coper
S
S
Wolfarth
D000818:Animals; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D014150:Antipsychotic Agents; D018492:Dopamine Antagonists; D005260:Female; D005476:Fluphenazine; D007980:Levodopa / Q000627:therapeutic use*; D009127:Muscle Rigidity / Q000139:chemically induced / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar
D000978:Antiparkinson Agents; D014150:Antipsychotic Agents; D018492:Dopamine Antagonists; D007980:Levodopa; D005476:Fluphenazine