Potential drug-drug interactions on a tertiary-care hospital consultation-liaison psychiatry service.
Pharmacokinetic interactions involving the cytochrome P450 system have been a recent focus of clinical and research interest in psychopharmacology. The authors reviewed 100 consecutive patients seen on a consultation-liaison (C-L) psychiatry service for potential drug-drug interactions. The patients were taking a mean of 8.8 medications; for those undergoing organ transplantation the mean was 12.9. While both enzyme inhibitors (n = 87) and substrates (n = 89) were commonly used, only rarely were they used in the same patient (n = 14). The authors conclude that the potential for drug interactions on a C-L psychiatry service is significant, necessitating awareness of this potential complication.
University of Minnesota, Department of Psychiatry, Minneapolis 55455, USA.
D E
DE
Adson
S J
SJ
Crow
W H
WH
Meller
R M
RM
Magraw
D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000502:physiology; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D006801:Humans; D001523:Mental Disorders / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D016377:Organ Transplantation / Q000523:psychology*; D010348:Patient Care Team; D011619:Psychotropic Drugs / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D012307:Risk Factors
D065607:Cytochrome P-450 Enzyme Inhibitors; D004791:Enzyme Inhibitors; D011619:Psychotropic Drugs; D003577:Cytochrome P-450 Enzyme System