Dual effect of 2-deoxy-D-glucose tetraacetate upon glucose-induced insulin release.
The effect of 2-deoxy-D-glucose tetraacetate upon glucose-stimulated insulin release was explored in pancreatic islets from either normal or hereditary diabetic rats. At a high concentration (10 mM), it decreased the secretory response to D-glucose, such an inhibitory effect being more marked in the case of the alpha- than beta-anomer of the ester. At lower concentrations (0.19 to 1.7 mM), however, 2-deoxy-D-glucose tetraacetate augmented insulin secretion evoked by 8.3 mM D-glucose, with again a preference for the alpha-anomer of the ester. In relative terms, such an enhancing action was more marked in Goto-Kakizaki than normal rats. Hence, it is proposed that selected esters of non-nutrient carbohydrates could be used as insulinotropic tools in the treatment of non-insulin-dependent diabetes mellitus.
Laboratory of Experimental Medicine, Brussels Free University, Belgium.
W J
WJ
Malaisse
L E
LE
Flores
M M
MM
Kadiata
D019342:Acetic Acid / Q000494:pharmacology*; D000818:Animals; D003847:Deoxyglucose / Q000494:pharmacology*; D003920:Diabetes Mellitus / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism*; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D007328:Insulin; D003847:Deoxyglucose; D005947:Glucose; D019342:Acetic Acid