[Genomic disorders in the mononuclear blood cells of those who worked in the cleanup of the accident at the Chernobyl Atomic Electric Power Station].
The results of molecular investigations of blood mononuclears from 120 clean-up workers after 7-9 years of Chernobyl accident with the total exposure radiation doses ranging from 5 to 76 cGr are presented. Structural polymorphism of the leukemia associated bcr and ribosomal RNA (rRNA) genes were studied using Southern blot hybridization. Allelic polymorphism of bcr gene with characteristic for leukemia allele distribution was detected in 16.6%. Rearrangements of rRNA genes were observed in 13% of Chernobyl accident clean-up workers.
Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kiev.
Z A
ZA
Butenko
I A
IA
Smirnova
K P
KP
Zak
E V
EV
Mikhaĭlovskaia
E A
EA
Ianok
E G
EG
Kishinskaia
D000483:Alleles; D004247:DNA / Q000097:blood / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D016044:Fusion Proteins, bcr-abl / Q000235:genetics / Q000528:radiation effects; D015894:Genome, Human; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics; D007963:Leukocytes, Mononuclear / Q000528:radiation effects* / Q000648:ultrastructure; D008854:Microscopy, Electron; D011110:Polymorphism, Genetic / Q000528:radiation effects; D011210:Power Plants; D012335:RNA, Ribosomal / Q000235:genetics / Q000528:radiation effects; D018788:Radioactive Hazard Release; D013997:Time Factors; D014455:Ukraine
D012335:RNA, Ribosomal; D004247:DNA; D016044:Fusion Proteins, bcr-abl