[The possible mechanism of the antiradiation effect of metallothionein: the stimulation of DNA replicative synthesis and of bone marrow cell proliferation].
Zn-MT and less apo MT (4-100 mkg/ml) in vitro stimulated the [3H]-thymidine incorporation in mice bone marrow cells, but ZnCl2, its combination with cysteine and mixture (ZnCl2 + cystine + albumin) inhibited DNA synthesis. In protected with Zn-MT (1-4 mg/kg) 10-15 min before irradiation (6 Gy) mice on 9th day after influencing the increasing of DNA replicative synthesis level and nuclear cell number in bone marrow were observed.
Koterov
A N
AN
State Research Center of Russia, Institute of Biophysics, Moscow.
Trebenok
Z A
ZA
Pushkareva
N B
NB
Nikol'skiĭ
A V
AV
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D002455:Cell Division / Q000187:drug effects / Q000528:radiation effects; D002478:Cells, Cultured; D004261:DNA Replication / Q000187:drug effects* / Q000528:radiation effects; D005720:Gamma Rays; D008668:Metallothionein / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013936:Thymidine / Q000378:metabolism / Q000528:radiation effects; D013997:Time Factors; D014316:Tritium
D011837:Radiation-Protective Agents; C021267:zinc thionein; D014316:Tritium; D008668:Metallothionein; D013936:Thymidine