Predictive washing test for evaluation of individual eczema risk.
It was the aim of our studies to estimate predictively the individual eczema risk for persons due to repetitive contact with washing-active substances, by a barrier function test on clinically healthy skin over 2 weeks. Within the scope of the study 3 groups with different atopy scores were compared. As washing solutions, 0.1 m SLS and a slightly acid soap-free washing emulsion were used in comparison to tap water. Prior to the 1st washing procedure, on days 3, 5, 8, 10, and 12, the transepidermal water loss, the horny layer moisture, and the skin blood flow were measured as parameters of barrier function, as well as the inflammatory reaction. The results prove that the atopy score has only limited validity as a predictive method for the acceptance of washing-active substances. The repetitive washing test, however, seems to be more adequate for evaluating the individual barrier function as well as the eczema risk. Irritation by a washing procedure may be greatly influenced by choice of the washing solution.
Dermatological Clinic of the Municipal Clinics Karlsruhe, Germany.
W
W
Gehring
M
M
Gloor
P
P
Kleesz
D000328:Adult; D003876:Dermatitis, Atopic / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D004485:Eczema / Q000139:chemically induced* / Q000453:epidemiology; D004655:Emulsions / Q000008:administration & dosage; D005069:Evaluation Studies as Topic; D005260:Female; D006235:Hand Disinfection; D006801:Humans; D008875:Middle Aged; D011237:Predictive Value of Tests; D012307:Risk Factors; D012720:Severity of Illness Index; D012867:Skin / Q000187:drug effects / Q000503:physiopathology; D012967:Sodium Dodecyl Sulfate / Q000008:administration & dosage / Q000009:adverse effects; D013501:Surface-Active Agents / Q000008:administration & dosage / Q000009:adverse effects; D013997:Time Factors; D014867:Water / Q000008:administration & dosage; D014870:Water Loss, Insensible / Q000187:drug effects
D004655:Emulsions; D013501:Surface-Active Agents; D014867:Water; D012967:Sodium Dodecyl Sulfate