Toxic epidermal necrolysis associated with treatment for preterm labor.
We report a 29-year-old pregnant woman who developed toxic epidermal necrolysis at 29 weeks of gestation after administration of ritodrine, indomethacin and betamethasone. Toxic epidermal necrolysis is an unreported side effect of this widely used combination of medications. Since toxic epidermal necrolysis is a potentially fatal disease, awareness of a possible association is warranted.
Department of Dermatology, Universitair Ziekenhuis Antwerpen, Belgium. Dockx@IBM.net
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N
Claessens
L
L
Delbeke
J
J
Lambert
L
L
Matthieu
C
C
Lafaire
E
E
Van Marck
D000328:Adult; D001623:Betamethasone / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D005865:Gestational Age; D005938:Glucocorticoids / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects / Q000627:therapeutic use; D007752:Obstetric Labor, Premature / Q000517:prevention & control*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced*; D012312:Ritodrine / Q000009:adverse effects / Q000627:therapeutic use; D013262:Stevens-Johnson Syndrome / Q000209:etiology*; D015145:Tocolysis / Q000009:adverse effects*; D015149:Tocolytic Agents / Q000009:adverse effects* / Q000627:therapeutic use
D005938:Glucocorticoids; D015149:Tocolytic Agents; D001623:Betamethasone; D012312:Ritodrine; D007213:Indomethacin