Synthesis of oligopeptide and peptidomimetic libraries.
The elaboration of peptide libraries prepared by either chemical or biological methods in a format useful for discovery of peptides with specific biological activities was first introduced in the 1980s. A virtual explosion of activity in this area has occurred recently, and the basic approaches have been applied to a wide variety of chemistries and for all manner of biological, chemical and physical targets. Recent advances include new synthetic methodologies, new analytical methods, new design methods and new assay procedures.
Hruby
V J
VJ
Department of Chemistry, University of Arizona, Tucson, Arizona, 85721, USA. hruby@mail.arizona.edu
Ahn
J M
JM
Liao
S
S
D001435:Bacteriophages / Q000235:genetics; D018716:Molecular Mimicry; D019151:Peptide Library; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000235:genetics
D019151:Peptide Library; D010455:Peptides