[Development of a new gastric ulcer model and the evaluation of drug effects].
A new gastric ulcer model was developed by the ischemia-reperfusion procedure in rats. The ischemia-reperfusion was produced by clamping the celiac artery and subsequent removal of the clamp. Until 36 hr after the ischemia, erosive lesions were observed in the gastric glands. However, 48 and 72 hr after the ischemia, gastric ulcers involving damage of muscularis mucosae were observed. Seven days after the ischemia, the injured areas were covered with regenerated mucosa. This model may be useful for investigating the mechanisms of pathogenesis of gastric ulcer and to evaluate efficacy of drugs.
Wada
K
K
Department of Clinical Pharmacology, Faculty of Medicine, Tottori University, Yonago, Japan.
Kamisaki
Y
Y
D000818:Animals; D004195:Disease Models, Animal; D005753:Gastric Mucosa / Q000098:blood supply; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000473:pathology