Expression of receptors for neuregulins, ErbB2, ErbB3 and ErbB4, in developing mouse cerebellum.
We have examined the expression of ErbB2, ErbB3 and ErbB4 in developing mouse cerebellum. ErbB2, ErbB3 and ErbB4 were all expressed in granule cells during cerebellar development. However, the expression pattern for each ErbB receptor changed with the developmental stage. Variations of signal transduction pathway through combinations of these ErbB receptors might have important roles in controlling cerebellar postnatal development.
Laboratory for Cellular Information Processing, Brain Science Institute, RIKEN, Saitama, Japan.
M
M
Ozaki
S
S
Kishigami
R
R
Yano
D000818:Animals; D015153:Blotting, Western; D002531:Cerebellum / Q000737:chemistry* / Q000166:cytology / Q000254:growth & development; D066246:ErbB Receptors / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental; D006023:Glycoproteins / Q000235:genetics*; D017403:In Situ Hybridization; D051379:Mice; D009412:Nerve Fibers / Q000737:chemistry; D020880:Neuregulins; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics*; D020893:Receptor, ErbB-3; D066247:Receptor, ErbB-4; D015398:Signal Transduction / Q000502:physiology; D013569:Synapses / Q000737:chemistry
D066246:ErbB Receptors; D006023:Glycoproteins; D020880:Neuregulins; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D018719:Erb-b2 Receptor Tyrosine Kinases; D020893:Receptor, ErbB-3; D066247:Receptor, ErbB-4; C587690:Erbb4 protein, mouse