Expression of endothelin-1 in amniotic fluid embolism and possible pathophysiological mechanism.
Since endothelin is a potent vasoconstrictor and bronchoconstrictor, endothelin-1 expression in the lung was investigated using immunohistological techniques in two cases of amniotic fluid embolism. Intense expression of endothelin-1 was observed in amniotic squames while weaker staining was seen in alveolar epithelium, bronchiolar epithelium and intraalveolar macrophages and focally in vascular endothelium. Endothelin-1 may play a role in the early and transient haemodynamic alteration of pulmonary hypertension in amniotic fluid embolism.
Department of Histopathology, Adelaide Women's and Children's Hospital, Australia.
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Khong
D004619:Embolism, Amniotic Fluid / Q000209:etiology / Q000378:metabolism*; D019332:Endothelin-1 / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008168:Lung / Q000378:metabolism; D011247:Pregnancy
D019332:Endothelin-1