Concerted evolution in an egg receptor for a rapidly evolving abalone sperm protein.
Gamete interactions during fertilization exhibit species specificity. In abalone, the sperm protein lysin species-specifically creates a hole in the egg envelope. Lysin evolves rapidly by positive Darwinian selection. Evolution of the egg receptor for lysin provides the selective pressure for lysin's divergence. The egg receptor for lysin is a tandemly repeated sequence that evolves by concerted evolution. Concerted evolution in the egg receptor could explain the rapid, adaptive evolution in sperm lysin and may provide an underlying molecular mechanism that gives rise to species-specific fertilization.
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093-0202, USA. jwswanson@ucsd.edu
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D000595:Amino Acid Sequence; D000818:Animals; D004527:Egg Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D019143:Evolution, Molecular; D005260:Female; D007438:Introns; D008297:Male; D008969:Molecular Sequence Data; D008974:Mollusca / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D009088:Mucoproteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D010063:Ovum / Q000737:chemistry / Q000502:physiology; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D012091:Repetitive Sequences, Nucleic Acid; D012641:Selection, Genetic; D016415:Sequence Alignment; D013045:Species Specificity; D013084:Sperm-Ovum Interactions; D013094:Spermatozoa / Q000737:chemistry / Q000502:physiology; D014817:Vitelline Membrane / Q000737:chemistry* / Q000378:metabolism
D004527:Egg Proteins; D009088:Mucoproteins; D011956:Receptors, Cell Surface; C113623:VERL protein, Haliotis; C010393:lysin, gastropoda