Existence of striatal nerve cells coexpressing CCK(B) and D2 receptor mRNAs.
Co-localization of CCK(B) and D2 receptor mRNAs was analysed in adjacent sections of nucleus caudate putamen of the rat by means of in situ hybridization. A distinct subpopulation of D2 mRNA containing striatal nerve cells (in the order of 10%) was shown to co-express CCK(B) and D2 receptor mRNAs. All the CCK(B) receptor mRNA-positive nerve cells were co-localized with D2 receptor mRNA. These results give one morphological substrate to the previously demonstrated CCK(B)/D2 receptor interactions in the striatum.
Hansson
A C
AC
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden.
Andersson
A
A
Tinner
B
B
Cui
X
X
Sommer
W
W
Fuxe
K
K
D000818:Animals; D001345:Autoradiography; D017403:In Situ Hybridization; D008297:Male; D017072:Neostriatum / Q000166:cytology* / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D011699:Putamen / Q000378:metabolism; D015347:RNA Probes; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011949:Receptors, Cholecystokinin / Q000096:biosynthesis*; D017448:Receptors, Dopamine D2 / Q000096:biosynthesis*
D015347:RNA Probes; D012333:RNA, Messenger; D011949:Receptors, Cholecystokinin; D017448:Receptors, Dopamine D2