Activity of various hydroxylated vitamin D3 analogs for improving phosphorus utilisation in chicks receiving diets adequate in vitamin D3.
1. Young chicks were used to evaluate the efficacy of 2 new vitamin D3 analogs relative to 1 alpha-hydroxycholecalciferol (1 alpha-OH D3) for their ability to improve the bioavailability of phytate-bound phosphorus (P) when added to P-deficient maize-soyabean meal diets that were superadequate in cholecalciferol. 2. Both 20-epi-19-nor-1,25-(OH)2 D3 and 20-epi-19-nor-1 alpha-OH D3 were observed to have phytate-P releasing activity, as measured by bone ash responses. 3. However, the bioactivity of the 2 new analogs differed when compared with 1 alpha-OH D3. The 20-epi-19-nor-1 alpha-OH D3 analog had a lower (P < 0.05) phytate-P releasing activity (45%) than either 1 alpha-OH D3 of 20-epi-19-nor-1,25-(OH)2 D3, which did not differ. 4. A dietary concentration of 10 to 15 micrograms/kg 1 alpha-OH D3 was found to optimize phytate-P utilisation in 2-week-old chicks.
Biehl
R R
RR
Department of Animal Sciences, University of Illinois, Urbana, USA.
Baker
D H
DH
Deluca
H F
HF
D000704:Analysis of Variance; D000821:Animal Feed; D000818:Animals; D001682:Biological Availability; D001842:Bone and Bones / Q000737:chemistry; D002112:Calcifediol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology*; D002117:Calcitriol / Q000031:analogs & derivatives / Q000493:pharmacokinetics / Q000494:pharmacology; D002645:Chickens; D005260:Female; D005527:Food, Fortified; D016226:Phosphorus, Dietary / Q000378:metabolism*; D010833:Phytic Acid / Q000378:metabolism / Q000493:pharmacokinetics
C114865:1-hydroxy-19-norvitamin D3; D016226:Phosphorus, Dietary; C083610:1,25-dihydroxy-19-norvitamin D3; D010833:Phytic Acid; D002117:Calcitriol; D002112:Calcifediol