Prevention of diarrhoea using pathogen specific monoclonal antibodies in an experimental enterotoxigenic E. coli infection in germfree piglets.
In the present study we describe the effect of oral application of mAB specific for ETEC F4ac fimbriae in an experimental ETEC challenge model in neonatal germfree piglets. The results show that mAB, specific for different F4ac epitopes protect animals against ETEC specific pathology. Moreover, the results show that protection is independent of F4ac epitope specificity.
de Geus
B
B
Department of Immunology, Institute for Animal Science and Health (ID-DLO), Lelystad, The Netherlands.
Harmsen
M
M
van Zijderveld
F
F
D000284:Administration, Oral; D000372:Agglutination Tests; D000818:Animals; D000831:Animals, Newborn; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000627:therapeutic use*; D000918:Antibody Specificity; D003967:Diarrhea / Q000517:prevention & control*; D004195:Disease Models, Animal; D004768:Enterotoxins / Q000096:biosynthesis; D000939:Epitopes / Q000276:immunology; D004926:Escherichia coli / Q000276:immunology* / Q000472:pathogenicity; D004927:Escherichia coli Infections / Q000517:prevention & control*; D005260:Female; D010861:Fimbriae, Bacterial / Q000276:immunology; D005856:Germ-Free Life; D008297:Male; D013552:Swine
D000911:Antibodies, Monoclonal; D004768:Enterotoxins; D000939:Epitopes