Effects of prenatal cocaine on hearing, vision, growth, and behavior.
The illicit use of cocaine has increased dramatically over the last 10-12 years. There has been a corresponding increase in cocaine abuse among obstetric patients and in the number of "cocaine babies." According to some estimates, these children make up more than half of the drug-associated births. This problem is therefore a major public health concern. Consequently, our laboratory investigated the effects of prenatal cocaine exposure on hearing, vision, growth, and exploratory/stress behavior. This chapter summarizes the literature on animals and humans on these topics and presents new observations from our laboratory. In terms of maternal toxicity, prenatal cocaine exposure causes hypertension, placental abruption, spontaneous abortion, poor pregnancy weight gain, and undernutrition secondary to appetite suppression. Some offspring effects include in utero growth retardation, cephalic hemorrhage, fetal edema, altered body composition, congenital malformations, and even pre- and postnatal death. The offspring can also exhibit a variety of behavioral, visual, hearing, and language disorders. Differential effects of animal strain and late gestational cocaine exposure are discussed. Comparisons are made between prenatal cocaine, the fetal alcohol syndrome, and the effects of prenatal undernutrition. Recommendations for clinical assessment and intervention are made.
Department of Obstetrics and Gynecology, Wayne State University of Medicine, Detroit, Michigan 48201, USA.
M W
MW
Church
W J
WJ
Crossland
P A
PA
Holmes
G W
GW
Overbeck
J P
JP
Tilak
D000014:Abnormalities, Drug-Induced; D000818:Animals; D002648:Child; D003042:Cocaine / Q000633:toxicity; D005314:Embryonic and Fetal Development / Q000187:drug effects; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D006128:Growth / Q000187:drug effects; D006309:Hearing / Q000187:drug effects*; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D011297:Prenatal Exposure Delayed Effects; D013315:Stress, Psychological; D019966:Substance-Related Disorders; D014785:Vision, Ocular / Q000187:drug effects*
D003042:Cocaine