A novel orally active endothelin-A receptor antagonist, ZD1611, prevents chronic hypoxia-induced pulmonary hypertension in the rat.
Bialecki
R A
RA
BioMedical Research Station, Zeneca, Inc, Wilmington, Del, USA.
Stinson-Fisher
C
C
Murdoch
W
W
Bertelsen
D
D
Desiato
M
M
Rumsey
W
W
D000818:Animals; D002908:Chronic Disease; D065128:Endothelin Receptor Antagonists; D006976:Hypertension, Pulmonary / Q000209:etiology / Q000517:prevention & control*; D000860:Hypoxia / Q000150:complications*; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D044022:Receptor, Endothelin A
D065128:Endothelin Receptor Antagonists; D044022:Receptor, Endothelin A