Inhibiting the assembly of protein-protein interfaces.
Protein-protein association is found throughout mechanisms of cellular growth and differentiation, and viral replication. Inhibiting the assembly of protein complexes, therefore, presents itself as a novel means of inhibition for a wide variety of cellular and viral events. Peptides and small molecules that modify the overall quaternary structure of a selection of receptor-ligand interactions and oligomeric viral enzymes have been developed recently.
Zutshi
R
R
Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.
Brickner
M
M
Chmielewski
J
J
D006678:HIV / Q000201:enzymology; D006801:Humans; D011485:Protein Binding; D011487:Protein Conformation; D011500:Protein Synthesis Inhibitors / Q000378:metabolism*; D018139:Simplexvirus / Q000201:enzymology; D014780:Viruses / Q000201:enzymology*
D011500:Protein Synthesis Inhibitors