[The manifestations of the immediate bioincompatibility reaction in patients undergoing restorative heart operations].
The generation in plasma the anodic autoprecipitating protein, or autoprecipitin (AAP), as the bioincompatibility reaction under influence of a number of alien components during cardiac operations with using cardiopulmonary bypass, heterotopic vascular autotransplants and artificial valve implants was studied in 257 patients. Selective formation of the AAPs in result of their inductors effect was discovered by the methods of immunodiffusion and immunoelectrophoresis in blood of patients within operation periods and early postoperation hours. Repeated and reiterated generation of the AAPs due to bioincompatibility in patients with coronarosclerosis and endocarditis, undergoing prosthetic cardiac operations may favour developing reaction of immediate hypersensitivity with complications and has prognostic value.
Shevchenko
V S
VS
Institute of Cardiovascular Surgery, Academy of Medical Sciense, Ukraine.
D001323:Autoantibodies / Q000097:blood; D001672:Biocompatible Materials / Q000009:adverse effects*; D001798:Blood Proteins / Q000032:analysis; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000097:blood / Q000601:surgery; D004696:Endocarditis / Q000097:blood / Q000601:surgery; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000097:blood / Q000209:etiology*; D005779:Immunodiffusion; D007122:Immunoelectrophoresis; D011234:Precipitins / Q000097:blood; D013997:Time Factors
D001323:Autoantibodies; D001672:Biocompatible Materials; D001798:Blood Proteins; D011234:Precipitins