Age as a prognostic factor in breast cancer.
We retrospectively analysed data from 1751 patients with non-metastatic and non-inflammatory breast cancer treated in our institution between 1977 and 1989, in order to evaluate the link between age and prognosis in breast cancer. We chose three age groups (1): < or = 33 (n = 67), 34-40 ( n = 155), > 40 years (n = 1529). There were no significant differences in the distribution of clinical tumor size (T), histological node status (N), histology of the primary-tumor and progesterone receptor levels (PR). Younger patients had a higher proportion of SBR III (p < 0.0001), and of Estradiol Receptor negative tumors (EP). There was a significant difference between the three groups in terms of overall survival (p < 0.035), breast cancer specific survival (p < 0.0001) and relapse-free survival (p < 0.0002). Younger patients had a significantly poorer prognosis (survival and relapse) than older ones. Multivariate analysis of specific survival demonstrated that young age at diagnosis was a poor independent prognostic factor.
Centre Oscar Lambret (Northern France Cancer Centre), Lille, France.
L
L
Vanlemmens
M
M
Hebbar
J P
JP
Peyrat
J
J
Bonneterre
D000328:Adult; D000367:Age Factors; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D015999:Multivariate Analysis; D011379:Prognosis; D011959:Receptors, Estradiol / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D012189:Retrospective Studies
D011959:Receptors, Estradiol; D011980:Receptors, Progesterone