Cardiopulmonary bypass in a gravid patient: perioperative changes in endothelin levels.
Transient elevations of the potent vasoconstrictive peptide endothelin have been reported to occur with the institution of cardiopulmonary bypass. We measured plasma endothelin levels in a 24-year-old gravid patient undergoing a mitral valve replacement operation. Plasma endothelin levels increased by more than 250% in the first 24 hours postoperatively and remained elevated above baseline values at 36 hours postoperatively.
Department of Surgery, Medical University of South Carolina, Charleston 29425, USA.
J L
JL
Zellner
S B
SB
Kribbs
B H
BH
Dorman
F G
FG
Spinale
D000328:Adult; D002315:Cardiopulmonary Bypass; D016232:Endothelins / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008943:Mitral Valve; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000601:surgery*; D011475:Prosthesis Failure; D012086:Reoperation; D013927:Thrombosis / Q000601:surgery
D016232:Endothelins