Submolecular resolution of single macromolecules with atomic force microscopy.
The intrinsically high signal-to-noise ratio of atomic force microscopy (AFM) permits structural determination of individual macromolecules to, at times, subnanometer resolution directly from unprocessed images, avoiding the conditions and possible consequences of averaging over an ensemble of molecules. In this article, we will review some of the most recent achievements in imaging single macromolecules with AFM.
Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville 22908, USA.
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DM
Czajkowsky
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Z
Shao
D008565:Membrane Proteins / Q000032:analysis; D018625:Microscopy, Atomic Force / Q000295:instrumentation / Q000379:methods*
D008565:Membrane Proteins