Enzyme mediated C-C bond formation.
A number of significant biocatalysts have been investigated over the past year to improve accessibility, functional knowledge and use in developing synthetic applications. In particular, accumulating protein structural information has facilitated major advances in the detailed understanding of catalytic events and has, therefore, set the stage for rational protein engineering. This will have important implications for the future scope of practical applications, the first of which are currently being industrialized.
Department of Organic Chemistry, Rheinisch-Westfälische Technische Hochschule Aachen, Professor-Pirlet-Str. 1, D-52056, Aachen, Germany. fessner@rwth-aachen.de
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D019748:Carbon-Carbon Double Bond Isomerases / Q000378:metabolism*; D019755:Carbon-Carbon Lyases / Q000378:metabolism*; D002384:Catalysis; D002617:Chemical Industry; D005634:Fructose-Bisphosphate Aldolase / Q000378:metabolism; D006801:Humans; D011485:Protein Binding; D011487:Protein Conformation
D019755:Carbon-Carbon Lyases; D005634:Fructose-Bisphosphate Aldolase; D019748:Carbon-Carbon Double Bond Isomerases