Serum tumor necrosis factor in patients with gastric cancer.
We have measured serum TNF-alpha levels in 220 gastric cancer patients, 9 patients with gastric polyps or ulcers, 9 hepatitis B carriers and 85 normal controls. The results showed that no positive TNF-alpha value (> 10 pg/ml) was detected in Hepatitis B carriers and benign gastric lesions' patients and normal controls. In the cancer group, 17 out of 220 patients (7.7%) had positive-TNF-alpha values. The proportion of TNF-alpha positive was 6.8% in stage I disease, 6.5% in stage II disease, 3.7% stage III, and 12.9% stage IV. No clinicopathologic factors were related to positive TNF-alpha value. TNF-alpha value was not an independent prognostic indicator The role of TNF-alpha in gastric cancer remains obscures.
Wu
C W
CW
Department of Surgery, Veterans General Hospital-Taipei, Taiwan, Republic of China. cwwu@ics1.vghtpe.gov.tw
Chi
C W
CW
Hsieh
M C
MC
Chao
M F
MF
Lui
W Y
WY
P'Eng
F K
FK
D000367:Age Factors; D000368:Aged; D002353:Carrier State; D005260:Female; D006509:Hepatitis B / Q000097:blood / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011127:Polyps / Q000097:blood / Q000276:immunology / Q000601:surgery; D011379:Prognosis; D012016:Reference Values; D013274:Stomach Neoplasms / Q000097:blood* / Q000276:immunology / Q000473:pathology / Q000601:surgery; D013276:Stomach Ulcer / Q000097:blood / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis* / Q000378:metabolism
D014409:Tumor Necrosis Factor-alpha