Inhibition of human immunodeficiency virus type 1 reverse transcriptase activity by cordatolides isolated from Calophyllum cordato-oblongum.
Cordatolide A and B were re-isolated from Calophyllum cordato-oblongum, an endemic species of Sri Lanka, and found to inhibit HIV-1 reverse transcriptase with IC50 values of 12.3 and 19.0 microM, respectively.
H R
HR
Dharmaratne
W M
WM
Wanigasekera
E
E
Mata-Greenwood
J M
JM
Pezzuto
D019380:Anti-HIV Agents / Q000494:pharmacology*; D003374:Coumarins / Q000494:pharmacology*; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors*; D015497:HIV-1 / Q000201:enzymology*; D010944:Plants / Q000737:chemistry*; D039681:Pyranocoumarins; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology*
D019380:Anti-HIV Agents; D003374:Coumarins; D039681:Pyranocoumarins; D018894:Reverse Transcriptase Inhibitors; C102712:soulattrolide; C113860:cordatolide A; D054303:HIV Reverse Transcriptase; C075959:calanolide A