Biochemical and biological analyses of farnesyl-protein transferase inhibitors.
The methods outlined in Subheading 3. provide a logical sequence of assays with which to evaluate the biochemical and biological properties of potential FPTase inhibitors. The clinical predictability of these assays must await the evaluation of one or more of these compounds in humans.
Department of Cancer Research, Merck Research Laboratories, West Point, PA, USA.
N E
NE
Kohl
K S
KS
Koblan
C A
CA
Omer
A
A
Oliff
J B
JB
Gibbs
D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors*; D000818:Animals; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D011905:Genes, ras; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D008822:Mice, Transgenic; D008967:Molecular Biology / Q000379:methods
D004791:Enzyme Inhibitors; D019883:Alkyl and Aryl Transferases; C064911:p21(ras) farnesyl-protein transferase