Benzodiazepines alter cochleo-cochlear loop in humans.
By using otoacoustic emission, we looked for change in outer hair cell (OHC) motile activity and medial olivocochlear (MOC) system inhibition due to benzodiazepine administration, a drug that is known to produce a pharmacological effect by interacting with GABAergic inhibitory neurotransmission. No effect was observed on OHC motile activity, in contrast benzodiazepines decreased MOC system effectiveness suggesting the existence of GABAergic fibers projecting onto the MOC system.
Laboratoire Neurosciences et Systèmes Sensoriels, Hôpital Edouard Herriot, Lyon, France.
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N
Morand
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Veuillet
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MC
Gagnieu
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P
Lemoine
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L
Collet
D000284:Administration, Oral; D000328:Adult; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D002465:Cell Movement / Q000187:drug effects*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D018072:Hair Cells, Auditory, Outer / Q000187:drug effects*; D006801:Humans; D008297:Male; D009412:Nerve Fibers / Q000187:drug effects; D009847:Olivary Nucleus / Q000033:anatomy & histology / Q000187:drug effects*; D017084:Otoacoustic Emissions, Spontaneous / Q000187:drug effects*; D010076:Oxazepam / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D014151:Anti-Anxiety Agents; D005680:gamma-Aminobutyric Acid; D010076:Oxazepam