Optical resolution of 1-arylethanols using transesterification catalyzed by lipases.
The enantioselective transesterification of various 1-arylethanols with vinyl acetate catalyzed by lipases has been studied in benzene. The phenyl, pyridyl, naphthyl, quinoryl, anthryl, phenanthryl and pyrenyl groups were used as the aryl groups. Amongst various lipases examined, the lipase from Candida antarctica (lipase CAL) is the best catalyst which shows high enantioselectivity and low substrate specificity.
Department of Molecular Science and Technology, Faculty of Engineering, Doshisha University, Kyoto, Japan. kkano@mail.doshisha.ac.jp
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K
Kano
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Negi
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Kawashima
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Nakamura
D000873:Anthracenes; D001555:Benzene Derivatives / Q000737:chemistry*; D002175:Candida; D004951:Esterification; D000431:Ethanol / Q000031:analogs & derivatives*; D008049:Lipase / Q000737:chemistry*; D011549:Pseudomonas; D012233:Rhizopus; D013237:Stereoisomerism
D000873:Anthracenes; D001555:Benzene Derivatives; D000431:Ethanol; D008049:Lipase