Antiplasmodial and cytotoxic metabolites from the Maltese sponge Agelas oroides.
From a Maltese sample of the marine sponge Agelas oroides, five compounds: oroidin (1), 2-cyano-4,5-dibromopyrrole (2), 4,5-dibromopyrrole-2-carboxylic acid (3), 4,5-dibromopyrrole-2-carboxylic acid methyl ester (4), and 4 alpha-methyl-5 alpha-cholest-8-en-3 beta-ol (5) have been isolated. For compounds 1-5, completely assigned 1H- and 13C-NMR data are reported for the first time. For 2 a single crystal X-ray crystallographic analysis proved its structure unambiguously. The X-ray analysis of 2 indicated it to crystallise in an unexpected polar space group. Biological activity assessment of all isolates indicate 5 to have moderate antiplasmodial activity, as well as being cytotoxic, and 2 to be moderately cytotoxic towards several cancer cell lines.
Institute for Pharmaceutical Biology, Technical University Braunschweig, Germany. g.koenig@tu-bs.de
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König
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Wright
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D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification*; D018360:Crystallography, X-Ray; D010961:Plasmodium / Q000187:drug effects*; D011161:Porifera / Q000737:chemistry*; D013057:Spectrum Analysis
D000962:Antimalarials; D000970:Antineoplastic Agents