Abolition of anaphylactic shock by Solanum lyratum Thunb.
We investigated the effects of the aqueous extract of Solanum lyratum THUNB. (Solanaceae) (SLAE) on the anaphylactic reactions. SLAE inhibited compound 48/80-induced anaphylactic shock 100% with a dose of 1.0 mg/g body weight (BW). When SLAE was pretreated at concentration ranging from 0.0001-1.0 mg/g BW, the serum histamine levels were reduced in a dose-dependent manner. Passive cutaneous anaphylaxis also inhibited to 69.3% by oral administration of SLAE (0.05 mg/g BW). Moreover, SLAE dose-dependently inhibited the histamine release from the rat peritoneal mast cells (RPMC) by compound 48/80. The level of cAMP in RPMC, when SLAE was added, significantly increased compared with that of normal control. These results indicate that SLAE possess strong antianaphylactic activity.
Kang
B
B
Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Chonbuk, South Korea.
Lee
E
E
Hong
I
I
Lee
J
J
Kim
H
H
D000707:Anaphylaxis / Q000097:blood / Q000209:etiology / Q000628:therapy*; D000818:Animals; D000906:Antibodies; D000242:Cyclic AMP / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D006636:Histamine Release / Q000187:drug effects*; D008407:Mast Cells / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D051381:Rats; D017208:Rats, Wistar; D003189:p-Methoxy-N-methylphenethylamine
D000906:Antibodies; D004365:Drugs, Chinese Herbal; D003189:p-Methoxy-N-methylphenethylamine; D000242:Cyclic AMP