Secretoneurin, a novel neuropeptide, in the human dental pulp.
Secretoneurin is a neuropeptide that is stored in and released from primary afferent neurones. By radioimmunoassay and immunohistochemistry, secretoneurin was here demonstrated in the human dental pulp and localized in varicose nerve fibres that were frequently associated with blood vessels. No significant correlation was found between the levels of immunoreactive secretoneurin and immunoreactive calcitonin-gene related peptide. The results suggest that primary afferent neurones of the human dental pulp contain secretoneurin, which may influence local inflammatory responses if it is released together with other neuropeptides.
Department of Oral Surgery and Oral Radiology, Dental School, University of Graz, Austria.
C
C
Pertl
W
W
Kaufmann
R
R
Amann
A
A
Heinemann
K
K
Ebeleseder
R
R
Polansky
A
A
Saria
S
S
Kim
D000293:Adolescent; D000328:Adult; D015740:Calcitonin Gene-Related Peptide / Q000032:analysis / Q000096:biosynthesis; D003782:Dental Pulp / Q000098:blood supply / Q000737:chemistry* / Q000294:innervation* / Q000378:metabolism; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008964:Molar, Third; D009412:Nerve Fibers / Q000737:chemistry; D015213:Neuroimmunomodulation; D009479:Neuropeptides / Q000032:analysis* / Q000096:biosynthesis; D011863:Radioimmunoassay; D053381:Secretogranin II
D009479:Neuropeptides; D053381:Secretogranin II; C081159:secretoneurin; D015740:Calcitonin Gene-Related Peptide