Azulenyl nitrone spin traps protect against MPTP neurotoxicity.
Azulenyl nitrones are a unique class of free radical spin-trapping compounds. We administered both a water-soluble and a lipid-soluble azulenyl nitrone to mice prior to administration of MPTP. Both compounds produced significant neuroprotection against depletions of dopamine and its metabolites measured 1 week after MPTP administration. There were no effects on MPP+ levels. These findings provide further evidence that free radical scavengers can produce significant neuroprotection against MPTP neurotoxicity.
Klivenyi
P
P
Neurology Service, Massachusetts General Hospital, Boston, Massachusetts, 02114, USA.
Matthews
R T
RT
Wermer
M
M
Yang
L
L
MacGarvey
U
U
Becker
D A
DA
Natero
R
R
Beal
M F
MF
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000037:antagonists & inhibitors*; D015655:1-Methyl-4-phenylpyridinium / Q000037:antagonists & inhibitors / Q000633:toxicity; D000818:Animals; D052176:Azulenes; D001923:Brain Chemistry / Q000187:drug effects; D004298:Dopamine / Q000378:metabolism; D005609:Free Radicals; D018698:Glutamic Acid / Q000633:toxicity; D020267:MPTP Poisoning; D008297:Male; D051379:Mice; D016202:N-Methylaspartate / Q000633:toxicity; D018696:Neuroprotective Agents / Q000494:pharmacology*; D009589:Nitrogen Oxides / Q000494:pharmacology*; D010084:Oxidation-Reduction; D012717:Sesquiterpenes / Q000494:pharmacology*; D013113:Spin Labels
D052176:Azulenes; D005609:Free Radicals; D018696:Neuroprotective Agents; D009589:Nitrogen Oxides; D012717:Sesquiterpenes; D013113:Spin Labels; C113630:azulenyl nitrone; D018698:Glutamic Acid; D016202:N-Methylaspartate; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D015655:1-Methyl-4-phenylpyridinium; D004298:Dopamine