Enhancement of oral absorption in selective 5-HT1D receptor agonists: fluorinated 3-[3-(piperidin-1-yl)propyl]indoles.
Chemistry and Biochemistry Departments, Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK.
J L
JL
Castro
I
I
Collins
M G
MG
Russell
A P
AP
Watt
B
B
Sohal
D
D
Rathbone
M S
MS
Beer
J A
JA
Stanton
D000284:Administration, Oral; D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D006801:Humans; D007211:Indoles / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology; D007408:Intestinal Absorption; D010880:Piperidines / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology; D044346:Receptor, Serotonin, 5-HT1D; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000378:metabolism; D011994:Recombinant Proteins / Q000819:agonists / Q000378:metabolism; D017366:Serotonin Receptor Agonists / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology
D007211:Indoles; D010880:Piperidines; D044346:Receptor, Serotonin, 5-HT1D; D011985:Receptors, Serotonin; D011994:Recombinant Proteins; D017366:Serotonin Receptor Agonists