Total structures of colistin minor components.
Structural characterization of the colistin (CL) components were carried out using Frit-fast atom bombardment liquid chromatography/mass spectrometry (Frit-FAB LC/MS), tandem mass spectrometry (MS/MS) and the amino acid analysis proposed by MARFEY, and the total structures of 4 minor components including the absolute configuration of the constituent amino acids were proposed. The structures of the minor components were the same as those of the main component colistin A or B except that L-leucine is replaced by L-valine or L-isoleucine.
Aichi Prefectural Institute of Public Health, Nagoya, Japan.
Y
Y
Ikai
H
H
Oka
J
J
Hayakawa
N
N
Kawamura
T
T
Mayumi
M
M
Suzuki
K
K
Harada
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002853:Chromatography, Liquid / Q000379:methods; D003091:Colistin / Q000737:chemistry*; D013058:Mass Spectrometry / Q000379:methods; D015394:Molecular Structure
D000900:Anti-Bacterial Agents; D003091:Colistin