Familial hemophagocytic lymphohistiocytosis: improved neurodevelopmental outcome after bone marrow transplantation.
A child with familial hemophagocytic lymphohistiocytosis (HLH) underwent allogeneic bone marrow transplantation (BMT) at age 5 months. At that time he showed delayed psychomotor development, and computed tomography revealed diffuse calcification. After BMT, a gradual neurodevelopmental normalization was observed. The potential ability of BMT to reverse neurodevelopmental deterioration in HLH should be considered.
Shuper
A
A
National Center of Pediatric Hematology-Oncology, Schneider Children's Medical Center of Israel, Petab Tiqva, Israel.
Attias
D
D
Kornreich
L
L
Zaizov
R
R
Yaniv
I
I
D016026:Bone Marrow Transplantation; D001921:Brain / Q000473:pathology; D002114:Calcinosis / Q000175:diagnosis; D015616:Histiocytosis, Non-Langerhans-Cell / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male