Uptake by man of aluminium in a public water supply.
1. After overnight fasting, two young male adults each received a single oral dose of 100 Bq 26Al in tap water. Coincidence gamma-ray spectrometry and accelerator mass spectrometry were used to determine the 26Al content of excretion collections and of blood samples. 2. Close to 100% of the intake was recovered in faeces during the first 7 days. Gastro-intestinal uptake, determined by comparing urinary excretion with patterns previously established following intravenous administration of 26Al, averaged 0.22% in the two subjects. 3. Uptake fractions based on comparisons of blood concentration following ingestion and injection were much lower, but were judged to be unreliable. It is concluded that aluminium present in most water supplies is unlikely to contribute as much as 1% of a typical daily uptake of 10 microg from food.
Biomedical Research, AEA Technology, Didcot, Oxon, UK.
N D
ND
Priest
R J
RJ
Talbot
D
D
Newton
J P
JP
Day
S J
SJ
King
L K
LK
Fifield
D000328:Adult; D017607:Aluminum Compounds / Q000032:analysis / Q000493:pharmacokinetics*; D001682:Biological Availability; D004064:Digestive System / Q000378:metabolism; D005243:Feces / Q000737:chemistry; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D011868:Radioisotopes; D015203:Reproducibility of Results; D013051:Spectrometry, Gamma; D014881:Water Supply
D017607:Aluminum Compounds; D011868:Radioisotopes