Bacterial cytotoxins target Rho GTPases.
Low molecular mass GTPases of the Rho family, which are involved in the regulation of the actin cytoskeleton and in various signal transduction processes, are the eukaryotic targets of bacterial protein toxins. The toxins covalently modify Rho proteins by ADP ribosylation, glucosylation, and deamidation, thereby inactivating and activating the GTPases.
Schmidt
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Institut für Pharmakologie und Toxikologie, Albert-Ludwigs-Universität Freiburg, Germany.
Aktories
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D000818:Animals; D001427:Bacterial Toxins / Q000633:toxicity*; D003013:Clostridium; D003599:Cytoskeleton / Q000187:drug effects; D003603:Cytotoxins / Q000633:toxicity*; D020558:GTP Phosphohydrolases / Q000378:metabolism*; D019204:GTP-Binding Proteins / Q000187:drug effects / Q000378:metabolism*; D020690:GTPase-Activating Proteins; D008322:Mammals; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D011506:Proteins / Q000187:drug effects / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects; D011503:Transglutaminases / Q000378:metabolism; D020703:ras GTPase-Activating Proteins; D018631:ras Proteins / Q000378:metabolism*
D001427:Bacterial Toxins; D003603:Cytotoxins; D020690:GTPase-Activating Proteins; D011506:Proteins; D020703:ras GTPase-Activating Proteins; D011503:Transglutaminases; D011065:Poly(ADP-ribose) Polymerases; D020558:GTP Phosphohydrolases; D019204:GTP-Binding Proteins; D018631:ras Proteins