A study of the influence of a gestodene-containing triphasic oral contraceptive on endometrial morphology.
The objective of the study was to investigate histological changes in the endometrium in 20 volunteers treated with a low-dose, gestodene-containing triphasic oral contraceptive. Endometrial biopsy specimens were taken before, during a 6-month period of oral contraceptive use and in a post-treatment period. These specimens were evaluated using light microscopy, scanning and transmission electron microscopy. In addition, ultrasound examinations of the uterus, endometrial thickness and ovaries were performed. The low-dose, gestodene-containing triphasic oral contraceptive had no adverse effects on the endometrium (e.g. no proliferation, no polyps, no inflammatory processes), was well tolerated and showed a low side-effect profile. The inhibition of endometrial transformation was demonstrated both by endometrial morphology as well as by endometrial thickness, as measured by transvaginal ultrasound examination.
Rabe
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Universitäts-Frauenklinik, Abteilung für Gynäkologische Endokrinologie und Fertilitätsstörungen, Heidelberg, Germany.
Leppien
G
G
Fossman
W G
WG
Hessing
C
C
Vladescú
E
E
Runnebaum
B
B
D000293:Adolescent; D000328:Adult; D003280:Contraceptives, Oral, Synthetic / Q000494:pharmacology*; D004717:Endometrium / Q000033:anatomy & histology* / Q000000981:diagnostic imaging / Q000187:drug effects*; D005260:Female; D006801:Humans; D008855:Microscopy, Electron, Scanning; D009652:Norpregnenes / Q000494:pharmacology*; D045167:Progesterone Congeners / Q000494:pharmacology*; D014463:Ultrasonography
D003280:Contraceptives, Oral, Synthetic; D009652:Norpregnenes; D045167:Progesterone Congeners; C033273:Gestodene