Update of gp130 cytokines in multiple myeloma.
Interleukin (IL)-6 plays a major role in the control of the survival and proliferation of myeloma cell lines and primary myeloma cells. The genes of the receptors of IL-6 have been cloned, and the major signaling pathways involved in gp130 IL-6 transducer activation have been identified. In addition, another five cytokines that activate the gp130 IL-6 transducer have been identified. We review the recent data on gp130 cytokines and gp130-mediated signal transduction, their involvement in myeloma cell biology, and we discuss the possible therapeutic applications of this knowledge.
Klein
B
B
INSERM U475, Montpellier, France.
D015703:Antigens, CD / Q000502:physiology*; D002455:Cell Division / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D050822:Cytokine Receptor gp130; D006801:Humans; D008562:Membrane Glycoproteins / Q000502:physiology*; D009101:Multiple Myeloma / Q000503:physiopathology* / Q000628:therapy; D009857:Oncogenes; D015398:Signal Transduction / Q000502:physiology*
D015703:Antigens, CD; C494199:IL6ST protein, human; D008562:Membrane Glycoproteins; D050822:Cytokine Receptor gp130