Does the switch from sandimmun to Sandimmun neoral reduce patient need for Phenihydine?
In patients receiving cyclosporine A (CyA)-based immunosuppressive therapy, Ca2+ channel blockers (CCBs) prevent the development of CyA-related nephrotoxicity in which increased Ca2+ content plays an important role. We evaluated the dynamics of the intracellular (erythrocytes) and extracellular (plasma) Ca2+ levels and the influence of the CCB, Phenihydine, on this process during the conversion from Sandimmun (S) to Sandimmun Neoral (SN). Forty-two patients were enrolled. The conversion from S to SN normalized the elevated CA2+ level of erythrocytes in groups with Phenihydine (n = 20) and without Phenyhidine (n = 12) 4 weeks after the switch (P < 0.05); this level remained stable until the end of study. Therefore we suggest that the switch from S to SN is effective in reducing elevated intracellular Ca2+ levels. The decrease of Ca2+ content in erythrocytes was similar in all groups switched to SN (with or without Phenihydine). The last effect should be an important argument to focus the further long-term investigations on the ability of CCBs to act as cytoprotective and neophroprotective agents during immunosuppressive protocols with the new microemulsion formulation of CyA.
Rosental
R
R
Department of Transplantation, Medical Academy of Latvia, Riga, Latvia.
Adamsone
I
I
Babarykin
D
D
Amerika
D
D
Pettersson
E
E
D000328:Adult; D002118:Calcium / Q000097:blood; D002121:Calcium Channel Blockers / Q000008:administration & dosage*; D016572:Cyclosporine / Q000008:administration & dosage* / Q000032:analysis; D004912:Erythrocytes / Q000737:chemistry; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000032:analysis; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D019188:Organ Preservation Solutions
D002121:Calcium Channel Blockers; D007166:Immunosuppressive Agents; D019188:Organ Preservation Solutions; C115525:newcastle organ perfusion fluid; D016572:Cyclosporine; D002118:Calcium