Nephron-sparing surgery and renal transplantation in patients with renal cell carcinoma and von Hippel-Lindau disease.
Renal cell carcinoma is a common manifestation of von Hippel-Lindau disease and an important cause of mortality in these patients. A contemporary approach to the treatment of localized renal cell carcinoma is outlined based upon several recently conducted multicentre reviews. When technically feasible nephron-sparing surgery can preserve renal function without compromising long-term survival in most patients. For those who develop end-stage renal failure as a result of treatment for renal cell carcinoma, excellent results with a limited risk for development of recurrence can be obtained with renal transplantation.
Department of Urology, Cleveland Clinic Foundation, Ohio 44195, USA. goldfad@cesmtp.cef.org
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Goldfarb
D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery*; D016030:Kidney Transplantation; D009367:Neoplasm Staging; D009392:Nephrectomy / Q000379:methods*; D016019:Survival Analysis; D016896:Treatment Outcome; D006623:von Hippel-Lindau Disease / Q000150:complications* / Q000473:pathology / Q000601:surgery*