Glycoproteins of the human milk fat globule in the protection of the breast-fed infant against infections.
Nonimmunological components in human milk can protect breast-fed infants against infection by microorganisms. The structural and functional characteristics of four such components are discussed. The mucin inhibits binding of S-fimbriated Escherichia coli to bucal epithelial cells; lactadherin prevents symptomatic rotavirus-induced infection; glycoaminoglycans inhibit binding of human immunodeficiency virus gp120 to its host cell CD4 receptor, and oligosaccharides provide protection against several pathogens and their toxins.
Peterson
J A
JA
Cancer Research Institute of Contra Costa, Walnut Creek, Calif 94596, USA. japer@ibm.net
Patton
S
S
Hamosh
M
M
D000595:Amino Acid Sequence; D000818:Animals; D000890:Anti-Infective Agents; D000954:Antigens, Surface / Q000737:chemistry; D001424:Bacterial Infections / Q000517:prevention & control*; D005260:Female; D006017:Glycolipids / Q000737:chemistry / Q000502:physiology*; D006023:Glycoproteins / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D007231:Infant, Newborn; D066292:Lipid Droplets; D008894:Milk Proteins / Q000737:chemistry; D008895:Milk, Human / Q000737:chemistry*; D008969:Molecular Sequence Data; D009077:Mucins / Q000737:chemistry / Q000502:physiology; D014777:Virus Diseases / Q000517:prevention & control*
D000890:Anti-Infective Agents; D000954:Antigens, Surface; D006017:Glycolipids; D006023:Glycoproteins; C098942:MFGE8 protein, human; D008894:Milk Proteins; D009077:Mucins; C110367:milk fat globule