Short note: The fetal origins hypothesis: linking pineal gland hypoplasia with coronary heart disease and stroke.
Pineal gland hypoplasia secondary to intrauterine malnutrition is suggested as a fetal contribution to sudden infant death syndrome, coronary artery disease and ischemic stroke. The loss of melatonin's antioxidant activity is proposed as an additional factor to consider in atherosclerotic vascular disease.
Department of Pathology, Houston Medical Center, Warner Robins, GA 31093, USA.
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Maurizi
D002561:Cerebrovascular Disorders / Q000209:etiology* / Q000473:pathology; D003327:Coronary Disease / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008550:Melatonin / Q000502:physiology; D010870:Pineal Gland / Q000196:embryology* / Q000473:pathology*; D010927:Placental Insufficiency / Q000150:complications / Q000473:pathology; D011247:Pregnancy; D013398:Sudden Infant Death / Q000209:etiology / Q000473:pathology
D008550:Melatonin