FGF signaling in skeletal development.
The fibroblast growth factor receptor family consists of four receptor tyrosine kinases which bind with varying affinity and specificity to a family of at least fifteen polypeptide ligands. The receptors and ligands perform many essential functions during growth, development and repair. Recent discoveries show that a growing number of skeletal abnormalities result from mutations in the fibroblast growth factor receptors. These findings have led to a greater understanding of the role of fibroblast growth factor signaling during skeletogenesis and have focused research interests on the effects of fibroblast growth factors on endochondral and intramembranous bone development.
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, Campus Box 8103, 660 S. Euclid Ave., St. Louis, MO 63110, USA.
M C
MC
Naski
D M
DM
Ornitz
D017398:Alternative Splicing; D000818:Animals; D001846:Bone Development / Q000235:genetics / Q000502:physiology*; D001848:Bone Diseases, Developmental / Q000235:genetics; D002356:Cartilage / Q000187:drug effects / Q000254:growth & development; D005121:Extremities / Q000196:embryology; D005346:Fibroblast Growth Factors / Q000502:physiology*; D006493:Heparin / Q000378:metabolism; D006497:Heparan Sulfate / Q000378:metabolism; D006801:Humans; D009999:Ossification, Heterotopic / Q000503:physiopathology; D010012:Osteogenesis; D017434:Protein Structure, Tertiary; D017468:Receptors, Fibroblast Growth Factor / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
D005346:Fibroblast Growth Factors; D006493:Heparin; D006497:Heparan Sulfate; D017468:Receptors, Fibroblast Growth Factor