Synthesis, structural characterization and antimicrobial studies of 2,4-pentanedione derivatives. Part I.
The title compounds have been synthesized in good yields by the interaction of 2,3,4-pentanetrione-3-oxime with ethanedithioamide in 1:1, 1:2, and 2:2 mole proportions. The structures of these compounds have been elucidated from its physico-chemical and spectral data and by correlation with well-known products. Preliminary screening of these compounds for biological activity against several microorganisms has indicated that they are selective growth inhibitors of Mycobacterium tuberculosis in particular.
Department of Chemistry, Institute of Science, Mumbai, India.
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Varadarajan
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Utekar
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SP
Malve
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010422:Pentanones / Q000138:chemical synthesis* / Q000494:pharmacology; D012545:Schiff Bases / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000890:Anti-Infective Agents; D010422:Pentanones; D012545:Schiff Bases