Interleukin-10 gene expression and adult T-cell leukemia.
Numerous studies have shown spontaneous IL-10 gene expression and synthesis in a variety of peripheral blood or bone marrow-derived leukemic cells. These include B-cells derived from various lymphoproliferative disorders. Since little is known regarding IL-10 expression in leukemic T-cells, we examined clinical specimens of patients with adult T-cell leukemia (ATL) for IL-10 expression. Sera from ATL patients show increased levels of IL-10 when compared with sera from healthy donors. IL-10 is constitutively produced by ATL cells and also by human T-cell leukemia virus type I (HTLV-I)-infected cell lines. It is thought that HTLV-I infection induces gene expression for IL-10. In this review, a transcriptional regulation of IL-10 gene expression by HTLV-I Tax and the possible role of the NF-kappaB pathway are described.
Department of Medicine, UCLA School of Medicine, Los Angeles, USA.
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Mori
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Prager
D016356:Gene Products, tax / Q000502:physiology*; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics / Q000378:metabolism*; D015458:Leukemia, T-Cell / Q000378:metabolism*; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000502:physiology; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D016376:Oligonucleotides, Antisense / Q000494:pharmacology; D051996:Transcription Factor RelA; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism
D016356:Gene Products, tax; D016328:NF-kappa B; D009363:Neoplasm Proteins; D016376:Oligonucleotides, Antisense; D051996:Transcription Factor RelA; D016753:Interleukin-10