Cefaclor concentration in radicular granuloma after a single oral administration.
1. Cefaclor concentrations in radicular granuloma and serum in nonfasting patients after a single oral administration of 500-mg cefaclor were assayed. 2. The mean peak concentrations in radicular granuloma and serum were 2.57 mcg/g and 7.41 mcg/ ml, respectively. The mean ratio of granuloma/serum concentration at the peak time was 0.35. 3. All cefaclor concentrations in radicular granuloma at the peak time exceeded the minimal inhibitory concentration for 90% of oral streptococci (1 mcg/ml) isolated from odontogenic infection.
Akimoto
Y
Y
Department of Oral Surgery, Nihon University School of Dentistry at Matsudo, Chiba, Japan. yoshi@mascat.nihon-u.ac.jp
Ikeda
M
M
Omata
H
H
Shibutani
J
J
Fujii
A
A
Kaneda
T
T
Yamamoto
H
H
Takato
T
T
D000284:Administration, Oral; D000328:Adult; D002433:Cefaclor / Q000097:blood / Q000493:pharmacokinetics*; D002511:Cephalosporins / Q000097:blood / Q000493:pharmacokinetics*; D004334:Drug Administration Schedule; D005260:Female; D006099:Granuloma / Q000378:metabolism*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009059:Mouth Diseases / Q000378:metabolism*
D002511:Cephalosporins; D002433:Cefaclor