Morphometric analysis of the temporal lobe in temporal lobe epilepsy.
OBJECTIVE
Using high-resolution magnetic resonance imaging (MRI), we examined the temporal neocortex and the underlying white matter in patients with unilateral temporal lobe epilepsy (TLE) and in control subjects.


METHODS
The images of 27 patients and 42 control subjects were registered into stereotaxic space, corrected for image intensity inhomogeneity, and automatically segmented into gray matter, white matter, and cerebrospinal fluid (CSF) over a predetermined extent of the temporal lobe. The surface between the gray matter and CSF was extracted, indices of curvature (IOC) of the surface were calculated, and a frequency histogram of the IOC was obtained.


RESULTS
There was significant bilateral reduction in the total volume of the temporal lobe and in the volume of gray matter. White matter volume was significantly reduced only in the temporal lobe ipsilateral to the seizure focus. There were significant changes in the position and amplitude of peaks in the frequency histogram of the IOC.


CONCLUSIONS
The volume of gray matter was negatively correlated with duration of epilepsy, suggesting that neocortical changes may be a consequence of seizures. Changes in the frequency histogram of the IOC suggested an additional alteration in the surface morphology of the temporal lobe in TLE, possibly related to sulcal widening.
Lee
J W
JW
McConnell Brain Imaging Center, Montreal Neurological Institute and Hospital, McGill University, PQ, Canada.
Andermann
F
F
Dubeau
F
F
Bernasconi
A
A
MacDonald
D
D
Evans
A
A
Reutens
D C
DC
D000293:Adolescent; D000328:Adult; D000465:Algorithms; D000704:Analysis of Variance; D001921:Brain / Q000033:anatomy & histology; D002555:Cerebrospinal Fluid; D002648:Child; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D019579:Neocortex / Q000473:pathology / Q000503:physiopathology; D003294:Seizures, Febrile / Q000175:diagnosis; D013702:Temporal Lobe / Q000033:anatomy & histology* / Q000473:pathology / Q000503:physiopathology