[Activation of kallikrein-kinin system, degranulating activity of neutrophils and blood-brain barrier in schizophrenia].
To evaluate permeability of blood-brain barrier (BBB) some immunological and biochemical indices were used. The levels of the activity of serum kallikrein-kinin system (KKS), compliment system, C-reactive protein (CRP) concentration, blood inhibitory potential, metabolic and degranulating activities of neutrophils, as well as functional activity of leukocytic elastase were investigated in 30 patients. Acute schizophrenic attack was accompanied by both activation of KKS and by the increase of functional activity of alfa-1-proteinase inhibitor. The increase of CRP levels, high hemolytic activity of complement as well as considerable degranulating activity of polymorphonuclear leukocytes may be the causes of the damage of BBB permeability during acute schizophrenic attack.
Shcherbakova
I V
IV
Neshkova
E A
EA
Dotsenko
V L
VL
Kozlov
L V
LV
Mishin
A A
AA
Platonova
T P
TP
Shcherbakova
E G
EG
Iarovaia
G A
GA
D000208:Acute Disease; D000328:Adult; D001812:Blood-Brain Barrier; D002097:C-Reactive Protein / Q000032:analysis; D015550:Cell Degranulation; D003165:Complement System Proteins / Q000032:analysis; D006801:Humans; D016234:Kallikrein-Kinin System / Q000502:physiology*; D007962:Leukocytes / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000502:physiology*; D010196:Pancreatic Elastase / Q000378:metabolism; D011480:Protease Inhibitors / Q000378:metabolism; D012559:Schizophrenia / Q000276:immunology / Q000378:metabolism*
D011480:Protease Inhibitors; D003165:Complement System Proteins; D002097:C-Reactive Protein; D010196:Pancreatic Elastase