Megakaryocytopoiesis: growth factors, cell cycle and gene expression.
Megakaryocytopoiesis is the process prior to the release of platelets into the blood vessel. It is regulated by a variety of cell-cell interactions and a number of cytokines with either stimulatory or inhibitory effects. It is the intent of this review to give an overview of the regulation of megakaryocytopoiesis in a comprehensive analysis of the most recent advances, with special emphasis on cytokines that stimulate or inhibit megakaryocytopoiesis and on the cell cycle and gene expression of megakaryocytes. A chapter will be devoted to the abnormal megakaryocytopoiesis in hematological diseases and, in particular, in myeloproliferative syndromes.
Laboratory of Experimental Hematology and Oncology, UCL, Brussels, Belgium. sbaatout@sckcen.be
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D001792:Blood Platelets / Q000502:physiology; D002453:Cell Cycle; D015870:Gene Expression; D006133:Growth Substances / Q000502:physiology*; D006410:Hematopoiesis; D006801:Humans; D008533:Megakaryocytes / Q000502:physiology*; D008875:Middle Aged
D006133:Growth Substances