Acute and relapsing experimental autoimmune encephalomyelitis in IL-4- and alpha/beta T cell-deficient C57BL/6 mice.
Experimental autoimmune encephalomyelitis follows a chronic relapsing course in several inbred strains of mice. To address the role of T cells in recovery and relapse, the clinical course of EAE was compared in C57BL/6 (B6) normal and immunodeficient mice following active immunization with MOG p35-55 or adoptive transfer of encephalitogenic peptide-specific T cell lines. The course of actively-induced EAE in B6 wild-type and IL-4 -/- mice was similar. B6 IL-4 -/- mice recovered normally from acute passive EAE, but did not relapse in contrast to wild-type B6 mice. EAE was progressive in B6 RAG -/- and alpha/beta TCR -/- mice, but the disease course could be arrested by infusion of normal spleen cells. When non-activated MOG peptide-specific T cells were transferred to wild-type or alpha/beta TCR -/- mice, spontaneous disease ensued in the mutants only.
Zhao
M L
ML
Department of Microbiology, Medical College of Wisconsin, Milwaukee 53226, USA.
Fritz
R B
RB
D000208:Acute Disease; D000818:Animals; D017690:Cell Transplantation; D018450:Disease Progression; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000378:metabolism* / Q000601:surgery; D015847:Interleukin-4 / Q000172:deficiency*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein / Q000276:immunology; D063308:Myelin-Oligodendrocyte Glycoprotein; D010446:Peptide Fragments / Q000276:immunology; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000172:deficiency*; D012008:Recurrence; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000378:metabolism / Q000502:physiology* / Q000637:transplantation
C571327:Mog protein, mouse; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D063308:Myelin-Oligodendrocyte Glycoprotein; D010446:Peptide Fragments; D016693:Receptors, Antigen, T-Cell, alpha-beta; D015847:Interleukin-4