On the mechanism of action of econazole, the capacitative calcium inflow blocker.
The ability of bovine serum albumin to reverse the inhibitory action of econazole and the unsaturated fatty acid oleate on store-dependent Ca2+ inflow was examined in Ehrlich ascites tumour cells. We report that inhibition of Ca2+ inflow by both compounds is reversed immediately upon addition of bovine serum albumin. It is concluded that the inhibitory action of econazole resembles that of unsaturated fatty acids. The mechanism appears to be one pertaining to nonspecific events at the plasma membrane, possibly involving alterations in plasma membrane fluidity/structure.
Istituto di Patologia Generale, Universita di Siena, Italy.
A
A
Gamberucci
R
R
Fulceri
A
A
Benedetti
F L
FL
Bygrave
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor; D004464:Econazole / Q000494:pharmacology*; D017136:Ion Transport / Q000187:drug effects; D008297:Male; D051379:Mice; D019301:Oleic Acid / Q000494:pharmacology; D012710:Serum Albumin, Bovine / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D002121:Calcium Channel Blockers; D012710:Serum Albumin, Bovine; D019301:Oleic Acid; D004464:Econazole; D002118:Calcium