Enzyme-linked immunoassay for respiratory syncytial virus is not predictive of bronchiolitis in sudden infant death syndrome.
Although respiratory syncytial virus (RSV)-infected infants may present with apnea, the role that RSV plays in sudden infant death syndrome (SIDS) is speculative. To determine whether RSV is associated with bronchiolitis in these patients, we examined histologic sections of lungs from 41 apparent SIDS cases and compared the results with those of enzyme-linked immunofluorescent assay (EIA) from nasal washings. Bronchiolitis was defined by a bronchiolar inflammatory cell infiltrate plus epithelial necrosis. A positive EIA was associated with bronchiolitis in 8 instances, compared with 6 having a positive EIA and negative histology, 14 having a negative EIA and positive histology, and 13 having EIA and histology both negative. These results yield a predictive value of a positive test of 57% and a predictive value of a negative test of 48% (P > .9 by chi square analysis). Although RSV of the upper respiratory tract may be related to SIDS, our results indicate that EIA of nasal washings is not predictive of bronchiolitis, and we recommend other means of verification of histologic results.
Department of Pediatric Pathology, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, 800 Marshall Street, Little Rock, AR 72202, USA.
D M
DM
Parham
R
R
Cheng
G E
GE
Schutze
B
B
Dilday
R
R
Nelson
S
S
Erickson
C
C
Kokes
F
F
Peretti
W Q
WQ
Sturner
D000914:Antibodies, Viral / Q000032:analysis*; D001988:Bronchiolitis / Q000175:diagnosis* / Q000821:virology; D004797:Enzyme-Linked Immunosorbent Assay; D005188:False Negative Reactions; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008168:Lung / Q000473:pathology* / Q000821:virology; D017817:Nasal Lavage Fluid / Q000821:virology; D011237:Predictive Value of Tests; D018357:Respiratory Syncytial Virus Infections / Q000150:complications / Q000175:diagnosis*; D012136:Respiratory Syncytial Viruses / Q000276:immunology*; D013398:Sudden Infant Death / Q000175:diagnosis* / Q000209:etiology
D000914:Antibodies, Viral