Effects of Alu insertions on gene function.
Alu elements are a family of short interspersed repetitive elements (SINEs) found exclusively in primates. These elements are around 300 base pairs long, are found in excess of one million copies per diploid genome, and are dispersed throughout the human genome. Alu elements are scattered by a mechanism called "retrotransposition". Three independent steps are involved in retrotransposition: transcription of the Alu repetitive element, reverse transcription of the Alu RNA and integration of the Alu cDNA. The fact that Alu elements retrotranspose so readily suggests that they have a myriad of effects on the genome, mostly by inactivating genes or altering their function. These characteristics of Alu repetitive elements point to these repetitive DNA fragments as a major driving force for evolution. In addition, Alu elements are known to adopt diverse functions depending on the context of the surrounding genetic material into which they insert. In this article, we review some of the evidence that demonstrates the functional significance of Alu repeats.
Szmulewicz
M N
MN
Department of Biological Sciences, Florida International University, Miami 33199, USA.
Novick
G E
GE
Herrera
R J
RJ
D020087:Alu Elements; D000818:Animals; D006801:Humans; D016254:Mutagenesis, Insertional; D018626:Retroelements
D018626:Retroelements