Binding of disodium cromoglycate to human serum albumin.
The binding of several benzopiranone derivatives to human serum albumin was determined. The antiallergic drug disodium cromoglycate binds weakly to serum albumin. However, its precursors, chromones of smaller size, were able to bind in a hydrophobic pocket in the protein, and are carried by serum albumin in blood.
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Ochoa de Aspuru
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AM
Zatón
D018927:Anti-Asthmatic Agents / Q000737:chemistry / Q000378:metabolism; D004205:Cromolyn Sodium / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D011485:Protein Binding; D012709:Serum Albumin / Q000737:chemistry* / Q000378:metabolism
D018927:Anti-Asthmatic Agents; D012709:Serum Albumin; D004205:Cromolyn Sodium