Age-related neurodegeneration and oxidative stress: putative nutritional intervention.
This review describes age-related changes that occur in neuronal function and cites evidence to show that these alterations may be the result of increased sensitivity to oxidative stress (OS). Evidence is presented to show that the abilities to mitigate the OS effects and to repair the damage from OS show decline as a function of age. Results from age- and OS-sensitive tests are given; these results indicate that one of the major sites of action of OS is the membranes, especially if compromised by high amounts of sphingomyelin, and one of the major effects of OS is to further alter the calcium disregulation in aging. It is suggested that attempts to increase antioxidant protection through diets comprised of fruits and vegetables identified as being high in total antioxidant activity might prevent or reverse the deleterious OS effects on neuronal aging.
Joseph
J A
JA
Neuroscience Laboratory, USDA Human Nutritional Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA.
Denisova
N
N
Fisher
D
D
Bickford
P
P
Prior
R
R
Cao
G
G
D000375:Aging / Q000502:physiology*; D006801:Humans; D019636:Neurodegenerative Diseases / Q000178:diet therapy*; D018384:Oxidative Stress / Q000502:physiology*