Synthesis of 1-(beta-D-glycopyranosyl)-3-deazapyrimidines from 2-hydroxy and 2-mercaptopyridines.
The synthesis of new 4- and 5-substituted-3-cyanopyridine nucleosides has been performed by reacting the silylated pyridines and penta-omicron-acetyl-alpha -D-glycopyranose in dichloroethane in the presence of SnCl4. The free nucleosides were tested for their potential activity against HIV and different types of tumor.
Chemistry Department, Faculty of Science, Qatar University, Doha, Egypt.
A M
AM
Attia
G H
GH
Elgemeie
I S
IS
Alnaimi
D011725:Pyridines / Q000737:chemistry*; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry*
D011725:Pyridines; D011743:Pyrimidines; C014047:hydroxypyridines; C029347:2-thiopyridine