Periurethral injection of autologous fat for the treatment of post-fistula repair stress incontinence: a preliminary report.
The aim of the study was to assess the effectiveness of periurethral injection of autologous fat for the treatment of stress incontinence caused by inherent sphincter weakness in women following the repair of obstetric urogenital fistulae. Ten patients with symptomatic stress incontinence following repair of vesicovaginal or urethrovaginal fistula of obstetric origin were assessed clinically, by cystourethroscopy, and by Valsalva leak-point pressure (VLPP). Four showed some degree of bladder neck mobility and were treated by bladder neck suspension procedures. Six appeared to have pure sphincter weakness and were treated by periurethral injection of autologous fat. For logistic reasons, the initial follow-up was undertaken 2 weeks postoperatively, including clinical assessment and VLPP. Two patients were subjectively cured, 2 improved and 2 perceived no change in their symptoms following the procedure. The symptomatic changes correlated with the operative appearance, and with the subsequent changes in VLPP. Although numbers are small and follow-up short, we feel that these preliminary results justify further investigation of the technique in this most difficult group of patients.
Royal Victoria Infirmary, Newcastle upon Tyne, UK.
P
P
Hilton
A
A
Ward
M
M
Molloy
O
O
Umana
D000273:Adipose Tissue / Q000637:transplantation*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007267:Injections; D011183:Postoperative Complications / Q000601:surgery*; D014182:Transplantation, Autologous; D014521:Urethra; D014550:Urinary Incontinence, Stress / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D014563:Urodynamics; D014719:Vesicovaginal Fistula / Q000601:surgery*