Quantification of retinal oxygen consumption changes from preretinal oxygen transients.
BACKGROUND
In the avascular retina of the guinea-pig all the oxygen supply is from the choroid. Under these circumstances we had proposed, on theoretical grounds, that a change in retinal oxygen consumption would modulate the preretinal oxygen level.


METHODS
In the present study in guinea-pigs,the oxygen consumption of the outer retina was modulated by light-dark exposure while preretinal oxygen tension was monitored.


RESULTS
The results were in complete agreement with the proposed mathematical models.


CONCLUSIONS
The present study demonstrates that it is feasible to quantify oxygen consumption changes in a known retinal layer from measurements of preretinal oxygen tension.
Lions Eye Institute, The University of Western Australia, Nedlands, Australia. cringle@cyllene.uwa.edu.au
S J
SJ
Cringle
D Y
DY
Yu
V A
VA
Alder
E N
EN
Su
P K
PK
Yu
D000818:Animals; D003623:Dark Adaptation; D006168:Guinea Pigs; D017736:Ion-Selective Electrodes; D008027:Light; D008962:Models, Theoretical; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption; D012160:Retina / Q000378:metabolism*
D010100:Oxygen