Sequential hemodynamic activation of motor areas and the draining veins during finger movements revealed by cross-correlation between signals from fMRI.
Activity in the human supplementary motor area (SMA), primary motor cortex (M1), and the draining vein of the motor cortex during a visually triggered finger opposition task was measured by functional magnetic resonance imaging with a repetition time of 1 s. Sequential hemodynamic activation in these areas was revealed by cross-correlating a signal sequence in M1 directly with signal sequences from SMA and the draining vein, and applying polynomial fitting with the aid of Akaike's information criterion. We succeeded in detecting a time delay of approximately 0.5 s between the activations of SMA and M1, and a delay of nearly 1.3 s between the activations of M1 and its draining vein. The new combination of fMRI and data analysis techniques has attained a time resolution comparable to those in preceding studies that used shorter fMRI repetition times of 100-200 ms.
Neuroscience Section, Electrotechnical Laboratory, Ibaraki, Japan.
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Kansaku
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Kitazawa
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Kawano
D000328:Adult; D005385:Fingers / Q000098:blood supply* / Q000502:physiology*; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009044:Motor Cortex / Q000502:physiology*; D009068:Movement / Q000502:physiology*; D012039:Regional Blood Flow; D014680:Veins / Q000502:physiology