[The protective action of ellagic acid in experimental myocarditis].
The article presents the material on the study of the cardioprotective effect of ellagic acid on a model of neoepinephrine myocarditis in rats. In doses of 0.5-1 mg/kg ellagic acid causes a marked antioxidant effect. Restores the disturbed myocardial functions. The reference-agent vitamin E (50 mg/kg) yields to ellagic acid as a cardioprotector. The effect of 0.5 mg/kg of ellagic acid was more stable than that of a 1 mg/kg dose. The cardioprotective activity of the drugs under study was determined according to the POL parameters in a myocardial homogenate and blood serum and according to the EEG parameters and the degree of cardiomyocyte cytolysis.
Central Research Laboratory, Ukranian Pharmaceutical Academy, Kharkov, Ukraine.
L V
LV
Iakovleva
A K
AK
Ivakhnenko
N D
ND
Buniatian
D000318:Adrenergic beta-Agonists; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004610:Ellagic Acid / Q000627:therapeutic use*; D007545:Isoproterenol; D009205:Myocarditis / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D051381:Rats; D024505:Tocopherols; D014810:Vitamin E / Q000031:analogs & derivatives / Q000627:therapeutic use; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D000318:Adrenergic beta-Agonists; D000975:Antioxidants; D002317:Cardiovascular Agents; D014810:Vitamin E; D004610:Ellagic Acid; D024502:alpha-Tocopherol; D007545:Isoproterenol; D024505:Tocopherols