A benefit-cost analysis of two-dose measles immunization in Canada.
In 1992, because of the limitations of the one-dose measles immunization program, the National Advisory Committee on Immunization (NACI) recommended a two-dose measles immunization program to eliminate measles. More recently, NACI recommended also a special catch-up program to prevent predicted measles outbreaks and to achieve an earlier elimination of measles. The objective of this study was to complete a benefit-cost analysis of a two-dose immunization program with and without a mass catch-up compaign compared with the current one-dose program. The resulting benefit: cost ratios vary between 2.61:1 and 4.31:1 depending on the strategy used and the age of the children targeted. Given the parameters established for this analysis, the benefits of a second-dose vaccination program against measles far outweight the costs of such a program under all scenarios.
Division of Immunization, Laboratory Centre for Disease Control (LCDC), Ottawa, Canada.
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Pelletier
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Chung
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Duclos
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Manga
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Scott
D000293:Adolescent; D000367:Age Factors; D002170:Canada / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003362:Cost-Benefit Analysis; D004196:Disease Outbreaks / Q000191:economics / Q000517:prevention & control; D006801:Humans; D007115:Immunization Schedule; D007223:Infant; D008457:Measles / Q000191:economics / Q000453:epidemiology / Q000517:prevention & control; D008458:Measles Vaccine / Q000008:administration & dosage* / Q000191:economics*; D022542:Measles-Mumps-Rubella Vaccine; D009107:Mumps / Q000191:economics / Q000517:prevention & control; D009108:Mumps Vaccine / Q000008:administration & dosage / Q000191:economics; D012409:Rubella / Q000191:economics / Q000517:prevention & control; D012410:Rubella Syndrome, Congenital / Q000191:economics / Q000517:prevention & control; D012411:Rubella Vaccine / Q000008:administration & dosage / Q000191:economics; D012680:Sensitivity and Specificity; D017778:Vaccines, Combined / Q000008:administration & dosage / Q000191:economics
D008458:Measles Vaccine; D022542:Measles-Mumps-Rubella Vaccine; D009108:Mumps Vaccine; D012411:Rubella Vaccine; D017778:Vaccines, Combined