[Skew deviation].
BACKGROUND
Skew deviation is a vertical ocular misalignment of prenuclear origin. Although well described in the literature, it is still probably underdiagnosed. Natural history of skew deviation is not well described in the literature.


OBJECTIVE
To describe the clinical presentations, etiologies and follow-up of skew deviation.


METHODS
Retrospective study of 29 patients diagnosed with skew deviation between 1993 and 1996.


RESULTS
The commonest cause was cerebrovascular accident (12/29) and the commonest localisation was mesencephalic (9/29). Other causes included surgery (7/29), tumor (4/29), trauma (3/29), degeneration (3/29), inflammatory (2/29), increased intracranial pressure (1/29). Other localisations included cerebellum (5/29), ponto-mesencephalic (3/29), and medulla (2/29). Vertical diplopia was always accompanied by other neuro-ophthalmologic abnormalities. 69.2% (18/26) patients were totally asymptomatic after 7.5 months. 30.8% (8/26) were still symptomatic (diplopia). One patient required surgery, three patients were relieved with prisms, one patient needed monocular occlusion. One patient died during follow-up and precise data were lacking in two symptomatic patients.


CONCLUSIONS
Skew deviation is not so rare, 10% of the cases referred to us for diplopia in 3 years. The diagnosis of skew deviation should be entertained when vertical diplopia cannot be explained by pathology of extraocular muscles, peripheral or central cranial nerve III or IV palsies, myasthenia, or orbital pathology. Prognosis for recovery in patients with skew deviation is good. 70% will recover, after a median time of 7.5 months. Surgery should be postponed at least for 12 months.
Hôpital Ophtalmique Jules Gonin, Lausanne. fborruat@hola.hospvd.ch
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Borruat
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Gianoli
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Maeder
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Bogousslavsky
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001933:Brain Stem / Q000503:physiopathology; D002648:Child; D004172:Diplopia / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D005260:Female; D005403:Fixation, Ocular / Q000502:physiology; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009802:Oculomotor Nerve / Q000503:physiopathology; D012189:Retrospective Studies; D013285:Strabismus / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology