Role of PTHrP and PTH-1 receptor in endochondral bone development.
Parathyroid hormone-related peptide (PTHrP) has important functions in the control of cellular growth and differentiation. Acting, at least in part, through the PTH-1 receptor, PTHrP profoundly influences chondrocytic and osteogenic cell biology. Studies using knockout and transgenic mouse technology have played a pivotal role in unraveling the physiological role of PTHrP and its receptor in endochondral bone development and adult skeletal homeostasis. Further clarification of these functions will have far-reaching implications in our general understanding of skeletogenesis and the pathophysiology of human skeletal disorders.
Karaplis
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AC
Division of Endocrinology, Department of Medicine, and Lady Davis Institute for Medical Research, McGill University, Montreal, Canada. akarapli@ldi.jgh.mcgill.ca
Deckelbaum
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RA
D000818:Animals; D017209:Apoptosis; D001846:Bone Development / Q000502:physiology*; D019485:Bone Morphogenetic Proteins / Q000502:physiology; D016723:Bone Remodeling / Q000502:physiology; D002356:Cartilage / Q000166:cytology; D002454:Cell Differentiation / Q000187:drug effects; D053823:Hedgehog Proteins; D006801:Humans; D051379:Mice; D010006:Osteoblasts / Q000502:physiology; D010024:Osteoporosis / Q000188:drug therapy; D044162:Parathyroid Hormone-Related Protein / Q000235:genetics / Q000502:physiology*; D044168:Receptor, Parathyroid Hormone, Type 1; D018016:Receptors, Parathyroid Hormone / Q000502:physiology*; D015534:Trans-Activators / Q000502:physiology
D019485:Bone Morphogenetic Proteins; D053823:Hedgehog Proteins; C473449:PTH1R protein, human; D044162:Parathyroid Hormone-Related Protein; D044168:Receptor, Parathyroid Hormone, Type 1; D018016:Receptors, Parathyroid Hormone; D015534:Trans-Activators