Urinary neopterin as a prognostic index of survival time in HIV-1 infection.
A prospective semi-longitudinal study was undertaken to determine if urinary neopterin was a predictor for survival in HIV-positive patients. One hundred and one HIV-positive subjects attending a department of genitourinary medicine over a 41-month period were included. Survival data were analysed 6 months after the end of recruitment. Ninety-two subjects were followed up for a minimum of 6 months. Survival figures at 1 and 2 years were 93% (SE 3%) and 79% (SE 5%). There was an inverse relationship between urinary neopterin excretion and 1 and 2-year survival. Two-year survival fell from 70% (SE 6%) for neopterin levels > or = 300 mmol/mol creatinine to 25% (SE 9%) for levels > or = 700 mmol/mol creatinine (P < 0.001). Urinary neopterin may be a useful non-invasive technique in predicting survival in HIV-positive patients.
Department of Genitourinary Medicine, City Hospital, Nottingham, UK.
K E
KE
Rogstad
L
L
Morgan
J
J
Hughes
D018791:CD4 Lymphocyte Count; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000276:immunology / Q000503:physiopathology* / Q000652:urine*; D015497:HIV-1; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D019798:Neopterin / Q000652:urine*; D011379:Prognosis; D011446:Prospective Studies; D017741:Survivors
D019798:Neopterin