Cases of systemic immediate-type urticaria associated with acellular diphtheria-tetanus-pertussis vaccination.
The authors found eight children who had systemic urticaria within 30 min after administration of acellular diphtheria-tetanus-pertussis (DTP) vaccines which contain gelatin as a stabilizer. The authors measured the specific IgE to gelatin and DTP toxoids in their sera, and found that none of the children had anti-gelatin IgE. Of the eight children, two had detectable levels of anti-toxoid IgE. As a negative control, of the 10 children who showed no allergic reaction to the acellular DTP vaccines, four also had detectable levels of anti-toxoid IgE. From these results, there was no obvious relationship between the specific IgE to the vaccine's component proteins and systemic urticaria to acellular DTP vaccines.
Sakaguchi
M
M
Department of Immunology, National Institute of Infectious Diseases, Tokyo, Japan.
Nakayama
T
T
Inouye
S
S
D001426:Bacterial Proteins / Q000009:adverse effects*; D002675:Child, Preschool; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000009:adverse effects*; D005260:Female; D005780:Gelatin / Q000009:adverse effects*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology*; D007073:Immunoglobulin E / Q000097:blood; D007223:Infant; D008297:Male; D012135:Respiratory Sounds; D014121:Toxoids / Q000009:adverse effects*; D014581:Urticaria / Q000276:immunology*
D001426:Bacterial Proteins; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D014121:Toxoids; D007073:Immunoglobulin E; D005780:Gelatin