Ketoconazole shampoo: effect of long-term use in androgenic alopecia.
BACKGROUND
The pathogenesis of androgenic alopecia is not fully understood. A microbial-driven inflammatory reaction abutting on the hair follicles might participate in the hair status anomaly.


OBJECTIVE
The aim of our study was to determine if ketoconazole (KCZ) which is active against the scalp microflora and shows some intrinsic anti-inflammatory activity might improve alopecia.


METHODS
The effect of 2% KCZ shampoo was compared to that of an unmedicated shampoo used in combination with or without 2% minoxidil therapy.


RESULTS
Hair density and size and proportion of anagen follicles were improved almost similarly by both KCZ and minoxidil regimens. The sebum casual level appeared to be decreased by KCZ.


CONCLUSIONS
Comparative data suggest that there may be a significant action of KCZ upon the course of androgenic alopecia and that Malassezia spp. may play a role in the inflammatory reaction. The clinical significance of the results awaits further controlled study in a larger group of subjects.
Department of Dermatopathology, University of Liège, Belgium.
C
C
Piérard-Franchimont
P
P
De Doncker
G
G
Cauwenbergh
G E
GE
Piérard
D000328:Adult; D000505:Alopecia / Q000188:drug therapy; D000704:Analysis of Variance; D000935:Antifungal Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006197:Hair / Q000187:drug effects; D006203:Hair Preparations; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use*; D008297:Male; D008914:Minoxidil / Q000627:therapeutic use; D012044:Regression Analysis; D012627:Sebaceous Glands / Q000187:drug effects; D013997:Time Factors; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use
D000935:Antifungal Agents; D006203:Hair Preparations; D014665:Vasodilator Agents; D008914:Minoxidil; D007654:Ketoconazole