Allelic loss of chromosome 10q23 is associated with tumor progression in breast carcinomas.
To determine the status of chromosome 10q23 in primary breast carcinomas, in situ and invasive carcinomas were analysed for allelic loss using microsatellite markers spanning the 10q23 region. No LOH was seen in pure intraductal carcinomas (0/20 cases). On the other hand, LOH was observed in 40% (17/42) of invasive carcinomas (P = 0.0005). Interestingly, in situ lesions found in invasive tumors displayed LOH. Allelic loss was also significantly associated with loss of the estrogen receptor (P = 0.011). Thus, loss of the 10q23 is strongly associated with tumor progression.
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
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S
Bose
S I
SI
Wang
M B
MB
Terry
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H
Hibshoosh
R
R
Parsons
D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology*; D002278:Carcinoma in Situ; D018270:Carcinoma, Ductal, Breast / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology*; D002879:Chromosomes, Human, Pair 10; D018450:Disease Progression; D005260:Female; D006801:Humans; D019656:Loss of Heterozygosity; D009154:Mutation; D009361:Neoplasm Invasiveness; D051059:PTEN Phosphohydrolase; D010744:Phosphoric Monoester Hydrolases; D017027:Protein Tyrosine Phosphatases / Q000235:genetics; D025521:Tumor Suppressor Proteins
D025521:Tumor Suppressor Proteins; D010744:Phosphoric Monoester Hydrolases; D017027:Protein Tyrosine Phosphatases; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human