[The effect of chemotherapy on the killer activity of the peripheral blood leukocytes in patients with multiple myeloma].
A total of 30 patients with multiple myeloma (MM) in the advanced stage of the disease course were examined. The results obtained suggest that in MM advanced stage blood leucocyte lymphoid population killer activity gets markedly depressed. Cyclophosphamide and prednisolone combined in monotherapy treatment of the condition make for the decrement in neutrophil cytotoxic function while polychemotherapy according to COP (combination of cyclophosphamide, vincristin and prednisolone) scheme results in predominant inhibition of lymphocyte killer activity.
Vozniuk
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VP
D000920:Antibody-Dependent Cell Cytotoxicity / Q000187:drug effects; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage / Q000031:analogs & derivatives; D006801:Humans; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology; D007962:Leukocytes / Q000187:drug effects* / Q000276:immunology; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000276:immunology; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D011239:Prednisolone / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
D018906:Antineoplastic Agents, Alkylating; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone