Cerebrospinal fluid levels of alpha-tocopherol in patients with multiple sclerosis.
We compared cerebrospinal fluid (CSF) and serum levels, and the CSF/serum ratio of alpha-tocopherol (vitamin E), measured by HPLC, in 36 patients with multiple sclerosis (MS) and 32 matched controls. The mean CSF vitamin E levels and the CSF/serum vitamin E ratio did not differ significantly between the two study groups. The serum levels of vitamin E and the serum vitamin E/cholesterol ratio were significantly lower in MS patients when compared with controls (P < 0.05 and P < 0.01, respectively). These values were not correlated with age, age at onset and duration of the disease in the patients group. These results suggest that CSF vitamin E concentrations are not a marker of activity of MS activity.
Department of Neurology Hospital Universitario Príncipe do Asturias, Alcalá de Henares, Madrid, Spain.
F J
FJ
Jiménez-Jiménez
F
F
de Bustos
J A
JA
Molina
C
C
de Andrés
T
T
Gasalla
M
M
Ortí-Pareja
M
M
Zurdo
J
J
Porta
F
F
Castellano-Millán
J
J
Arenas
R
R
Enríquez de Salamanca
D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid*; D014810:Vitamin E / Q000097:blood / Q000134:cerebrospinal fluid*
D015415:Biomarkers; D014810:Vitamin E