Metabolism of 2-aminophenol by Pseudomonas sp. AP-3: modified meta-cleavage pathway.
A novel pathway for 2-aminophenol metabolism by Pseudomonas sp. AP-3 is proposed. The proposed pathway is similar to that known for meta-cleavage of catechol except that one of the hydroxyl groups on the metabolites is replaced by an amino group. During the degradation of 2-aminophenol, 2-amino-2,4-pentadienoic acid is the last metabolite containing an amino group. We, therefore, propose a modified meta-cleavage pathway for the 2-aminophenol metabolism.
Takenaka
S
S
Division of Science of Biological Resources, Graduate School of Science and Technology, Kobe University, Rokko, Kobe 657-8501, Japan.
Murakami
S
S
Shinke
R
R
Aoki
K
K
D000627:Aminophenols / Q000378:metabolism*; D002396:Catechols / Q000378:metabolism; D002849:Chromatography, Gas; D013058:Mass Spectrometry; D010421:Pentanoic Acids / Q000032:analysis; D010848:Picolinic Acids / Q000032:analysis; D011549:Pseudomonas / Q000201:enzymology / Q000378:metabolism*; D019289:Pyruvic Acid / Q000032:analysis
D000627:Aminophenols; D002396:Catechols; D010421:Pentanoic Acids; D010848:Picolinic Acids; C027667:2-aminophenol; D019289:Pyruvic Acid; C034221:catechol; C030614:picolinic acid