Hepatitis, hyperglycemia, pleural effusion, eosinophilia, hematuria and proteinuria occurring early in clozapine treatment.
This report describes a 48-year-old caucasian male with schizophrenia who developed hepatitis, hyperglycemia, pleural effusion, eosinophilia, hematuria and proteinuria early in clozapine treatment which resolved on drug discontinuation. The literature on similar cases is reviewed.
Thompson
J
J
University of Pittsburgh School of Medicine, PA, USA.
Chengappa
K N
KN
Good
C B
CB
Baker
R W
RW
Kiewe
R P
RP
Bezner
J
J
Schooler
N R
NR
D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001772:Blood Cell Count; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003024:Clozapine / Q000009:adverse effects*; D004802:Eosinophilia / Q000097:blood / Q000139:chemically induced* / Q000000981:diagnostic imaging; D006417:Hematuria / Q000097:blood / Q000139:chemically induced* / Q000000981:diagnostic imaging; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000139:chemically induced* / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D010996:Pleural Effusion / Q000097:blood / Q000139:chemically induced* / Q000000981:diagnostic imaging; D011507:Proteinuria / Q000097:blood / Q000139:chemically induced* / Q000000981:diagnostic imaging; D012563:Schizophrenia, Paranoid / Q000188:drug therapy; D014057:Tomography, X-Ray Computed
D014150:Antipsychotic Agents; D003024:Clozapine