Role of PTHrP and PTH-1 receptor in endochondral bone development.
Parathyroid hormone-related peptide (PTHrP) has important functions in the control of cellular growth and differentiation. Acting, at least in part, through the PTH-1 receptor, PTHrP profoundly influences chondrocytic and osteogenic cell biology. Studies using knockout and transgenic mouse technology have played a pivotal role in unraveling the physiological role of PTHrP and its receptor in endochondral bone development and adult skeletal homeostasis. Further clarification of these functions will have far-reaching implications in our general understanding of skeletogenesis and the pathophysiology of human skeletal disorders.
Division of Endocrinology, Department of Medicine, and Lady Davis Institute for Medical Research, McGill University, Montreal, Canada. akarapli@ldi.jgh.mcgill.ca
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Karaplis
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Deckelbaum
D000818:Animals; D017209:Apoptosis; D001846:Bone Development / Q000502:physiology*; D019485:Bone Morphogenetic Proteins / Q000502:physiology; D016723:Bone Remodeling / Q000502:physiology; D002356:Cartilage / Q000166:cytology; D002454:Cell Differentiation / Q000187:drug effects; D053823:Hedgehog Proteins; D006801:Humans; D051379:Mice; D010006:Osteoblasts / Q000502:physiology; D010024:Osteoporosis / Q000188:drug therapy; D044162:Parathyroid Hormone-Related Protein / Q000235:genetics / Q000502:physiology*; D044168:Receptor, Parathyroid Hormone, Type 1; D018016:Receptors, Parathyroid Hormone / Q000502:physiology*; D015534:Trans-Activators / Q000502:physiology
D019485:Bone Morphogenetic Proteins; D053823:Hedgehog Proteins; C473449:PTH1R protein, human; D044162:Parathyroid Hormone-Related Protein; D044168:Receptor, Parathyroid Hormone, Type 1; D018016:Receptors, Parathyroid Hormone; D015534:Trans-Activators