Rheumatoid neutrophilic dermatitis.
Rheumatoid neutrophilic dermatitis (RND) is a rare disorder seen in patients with severe rheumatoid arthritis. We present a 63-year-old Japanese with seropositive rheumatoid arthritis and rheumatoid lung who showed erythematous plaques and papules with pustules on his extremities and buttocks. Histological examination revealed a dense neutrophilic infiltration the upper dermis and neutrophilic abscesses in the dermal papillae. obvious vasculitis was seen. We suggest that RND could be included within the concept of a neutrophilic vascular reaction and that this condition develops through immune complex-mediated and neutrophil-induced vascular damage.
Department of Dermatology, Tokyo Women's Medical College, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.
M M
MM
Ichikawa
Y
Y
Murata
Y
Y
Higaki
M
M
Kawashima
T
T
Furuya
T
T
Saito
D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000276:immunology; D003872:Dermatitis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology*; D012867:Skin / Q000473:pathology