Vasopressin, angiotensin II and renal responses during water immersion in hydrated humans.
1. The hypothesis was tested that in hydrated humans the release of arginine vasopressin and angiotensin II is suppressed by water immersion (WI) and that this is a mechanism of the immersion-induced diuresis and natriuresis. Seven male subjects on controlled sodium (65-75 mmol per 24 h for 4 days) and water intake were studied. 2. Plasma vasopressin was promptly suppressed by WI, declining from 0. 76 +/- 0.13 to 0.23 +/- 0.08 pg ml-1 (P < 0.05), with a concomitant increase in renal water output (CH2O) from -0.4 +/- 0.2 to 4.4 +/- 0.7 ml min-1 (P < 0.05). Subsequently, CH2O returned to the level of control, whereas plasma vasopressin remained suppressed. Plasma osmolality gradually increased from 285 +/- 1 to 289 +/- 1 mosmol kg-1 (P < 0.05). WI caused a 9-fold increase in renal sodium excretion. Plasma angiotensin II decreased from 27.1 +/- 5.3 to 4.3 +/- 0.7 pg ml-1 (P < 0.05), and the intraindividual correlation coefficients between sodium excretion rates and angiotensin II concentrations varied between 0.73 and 0.96 (P < 0.002). 3. The data demonstrate that plasma vasopressin and angiotensin II concentrations decrease during WI in hydrated humans, concomitantly with initial increases in CH2O and sodium excretion. Therefore, vasopressin could constitute a mediator of CH2O and angiotensin II of the natriuresis of WI. The subsequent return of CH2O to the level of control is, however, also caused by other factors.
Hammerum
M S
MS
Danish Aerospace Medical Centre of Research, Rigshospitalet 7805, Denmark.
Bie
P
P
Pump
B
B
Johansen
L B
LB
Christensen
N J
NJ
Norsk
P
P
D000328:Adult; D000804:Angiotensin II / Q000097:blood*; D001794:Blood Pressure; D004326:Drinking; D004837:Epinephrine / Q000097:blood; D006339:Heart Rate; D006801:Humans; D007101:Immersion; D007668:Kidney / Q000502:physiology*; D008297:Male; D009638:Norepinephrine / Q000097:blood; D009994:Osmolar Concentration; D012964:Sodium / Q000097:blood / Q000652:urine; D012982:Sodium, Dietary; D014667:Vasopressins / Q000097:blood* / Q000378:metabolism; D014882:Water-Electrolyte Balance / Q000502:physiology*
D012982:Sodium, Dietary; D014667:Vasopressins; D000804:Angiotensin II; D012964:Sodium; D009638:Norepinephrine; D004837:Epinephrine