The correlation of telomerase and IL-10 with leukemia transformation in a mouse model of chronic lymphocytic leukemia (CLL).
Telomerase activity is upregulated in activated and malignant lymphocytes. We studied the correlation of telomerase and IL-10 to leukemia transformation in the NZB mouse model of human chronic lymphocytic leukemia (CLL). Telomerase levels increased from early to late leukemic stages, likewise IL-10 gene expression levels increased with the leukemic progression. The inverse relationship of telomerase and IL-10 levels to the survival of NZB mice was also established. Our data suggested that telomerase and IL-10 were involved in transformation in the murine model of CLL and the detection of telomerase activities might be of value in the prediction of CLL progression.
Department of Pathology, New Jersey Medical School, Newark 07103, USA.
B
B
Peng
M
M
Zhang
R
R
Sun
Y C
YC
Lin
S Y
SY
Chong
H
H
Lai
D
D
Stein
E S
ES
Raveche
D000367:Age Factors; D000818:Animals; D001402:B-Lymphocytes / Q000201:enzymology / Q000276:immunology / Q000378:metabolism; D018956:CD5 Antigens / Q000032:analysis; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D004195:Disease Models, Animal; D016753:Interleukin-10 / Q000096:biosynthesis* / Q000235:genetics; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000201:enzymology* / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D008814:Mice, Inbred NZB; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000032:analysis; D012333:RNA, Messenger / Q000032:analysis; D019098:Telomerase / Q000096:biosynthesis*; D014407:Tumor Cells, Cultured
D018956:CD5 Antigens; D009687:Nuclear Proteins; D012333:RNA, Messenger; D016753:Interleukin-10; D019098:Telomerase