Microparticle resins as a potential nasal drug delivery system for insulin.
The application of various resins for the nasal delivery of insulin was examined in rabbits. Intranasal administration of human insulin (28 U, 1 mg) mixed with fractionated sodium polystyrene sulfonate powder (an anionic resin with a particle size of 20-45 microns) caused a rapid increase of the plasma insulin level 413.0 +/- 71.7 microU/ml (mean +/- S.D.) after 15 min, while intranasal administration of insulin alone caused little increase. The blood glucose level decreased from 118.8 +/- 18.5 mg/dl to 65.8 +/- 13.8 mg/dl at 45 min after administration. These results were superior to those obtained with the unfractionated resin. Styrene-divinylbenzene copolymer (a nonionic resin; 20-45 microns fraction) showed similar enhancement of nasal insulin absorption. In contrast, polyacrylester (a nonionic resin; 20-45 microns fraction) and cholestyramine (a cationic resin) did not promote insulin absorption. These results suggest that some resins may be useful for nasal delivery of insulin.
Takenaga
M
M
Division of Drug Delivery Systems, St. Marianna University School of Medicine, Kawasaki, Japan.
Serizawa
Y
Y
Azechi
Y
Y
Ochiai
A
A
Kosaka
Y
Y
Igarashi
R
R
Mizushima
Y
Y
D000281:Administration, Intranasal; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D016503:Drug Delivery Systems; D006801:Humans; D007328:Insulin / Q000008:administration & dosage*; D008297:Male; D011817:Rabbits; D012116:Resins, Plant / Q000008:administration & dosage*
D001786:Blood Glucose; D007328:Insulin; D012116:Resins, Plant