Development of total artificial heart with economical and durability advantages.
To develop a total artificial heart (TAH) pump system, we created a design paying particular attention to durability and cost. We adopted a pneumatically driven sac type artificial heart, where the configuration of the sac was decided according to the methodology of flow visualization. Its configuration is almost round to achieve as little stagnation as possible and a low turbulent flow. The main body of the sac was made using polyvinyl chloride (PVC) paste. The paste was poured into an external mold, and heated in a hot air drying oven. Coating was performed using polyurethane. The basic performance of this pump system was tested using a model circulation circuit, and a fitting study through acute animal experiment, using a healthy adult goat, was carried out. As for the TAH produced experimentally, a pump output exceeding 5.0 l/min in the model circulation circuit was provided. Implantation in the internal pleural cavity of a healthy adult goat, 55 kg in weight, proved possible and quite easy in comparison. It is thought that a more refined design in the connector part is desirable. Furthermore, a chronic experiment with the TAH will be carried out, and examination will need to be repeated in the future.
Department of Medical Engineering and Cardiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. yambe@idac.tohoku.ac.jp
T
T
Yambe
A
A
Fukutome
S
S
Kobayashi
S
S
Nanka
M
M
Yoshizawa
K
K
Tabayashi
H
H
Takeda
S
S
Nitta
D000818:Animals; D006041:Goats; D006354:Heart, Artificial / Q000191:economics* / Q000592:standards; D007564:Japan; D011140:Polyurethanes; D011143:Polyvinyl Chloride; D011474:Prosthesis Design
D011140:Polyurethanes; D011143:Polyvinyl Chloride