Reversible azoospermia in a patient treated with triazolam.
This is a report of a 26-year-old schizophrenic man treated with triazolam, levomepromazine, trifluoperazine and biperiden, who showed complete absence of spermatozoa in seminal analysis with normal plasma hormone levels. Sperm count reached 151 x 10(6)/ml after 6 months of triazolam withdrawal. A reversible effect of triazolam is suggested at the level of the germinal cells which are differentiating, without affecting the stem cells.
Arango
O
O
Department of Urology, Hospital del Mar, Autonomous University of Barcelona, Spain.
Bielsa
O
O
Grau
S
S
Gelabert-Mas
A
A
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects; D001712:Biperiden / Q000009:adverse effects; D016903:Drug Monitoring; D004359:Drug Therapy, Combination; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects*; D008297:Male; D008728:Methotrimeprazine / Q000009:adverse effects; D009845:Oligospermia / Q000139:chemically induced*; D012559:Schizophrenia / Q000188:drug therapy; D013076:Sperm Count / Q000187:drug effects; D014229:Triazolam / Q000009:adverse effects*; D014268:Trifluoperazine / Q000009:adverse effects
D014150:Antipsychotic Agents; D006993:Hypnotics and Sedatives; D001712:Biperiden; D014229:Triazolam; D014268:Trifluoperazine; D008728:Methotrimeprazine