Use of activated heterocyclic amines in the screening of dietary antimutagens.
Experimental methods suitable for detecting antimutagenic substances against heterocyclic amines are described. The proposed methodology will allow identification of direct interactions between the metabolically activated form of a heterocyclic amine and an antimutagenic compound.
Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama 700, Japan. hayatsu@ph2ews.1.okayama-u.ac.jp
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Hayatsu
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Arimoto-Kobayashi
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Negishi
D000588:Amines / Q000633:toxicity*; D016587:Antimutagenic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D004032:Diet; D006427:Hemin; D006571:Heterocyclic Compounds / Q000633:toxicity*; D009153:Mutagens / Q000633:toxicity*; D012685:Sepharose
D000588:Amines; D016587:Antimutagenic Agents; D006571:Heterocyclic Compounds; D009153:Mutagens; D006427:Hemin; D012685:Sepharose