No association between apolipoprotein E alleles and olivopontocerebellar atrophy.
Apolipoprotein E (apo E) epsilon4 is a risk factor for sporadic and late-onset familial Alzheimer's disease, but it is not well known whether the apo E is associated with spinocerebellar degeneration. We studied the frequency of apo E allele in 59 olivopontocerebellar atrophy (OPCA) patients, including 13 pathologically confirmed cases. The distribution of the apo E allele frequency did not differ between OPCA patients and controls. Apo E allele does not influence the development of OPCA.
Third Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
H
H
Toji
H
H
Kawakami
T
T
Kawarai
T
T
Nakayama
O
O
Komure
S
S
Kuno
S
S
Nakamura
D000483:Alleles; D001053:Apolipoproteins / Q000235:genetics*; D053399:Apolipoproteins D; D004198:Disease Susceptibility; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009849:Olivopontocerebellar Atrophies / Q000235:genetics*
D001053:Apolipoproteins; D053399:Apolipoproteins D; D009419:Nerve Tissue Proteins