Haemostatic changes; plasma levels of alpha2-antiplasmin-plasmin complex and thrombin-antithrombin III complex in female breast cancer.
OBJECTIVE
Disorders of hemostasis in patients with malignancies are based on several mechanisms, such as ability of the tumor to alter the coagulation system by producing blood clotting factors or decreasing their inhibitors by increasing fibrinolysis, and by inducing an alteration of blood vessels in relation to the state of local invasion. We investigated the fibrinolytic system marker alpha2-antiplasmin-plasmin complex (APP) and clotting system marker thrombin-antithrombin III complex (TAT) in patients with breast cancer and compare them with CA 15-3, the most well-known breast cancer antigen.


METHODS
Plasma levels of APP and TAT and serum level of CA 15-3 were determined in 57 patients with breast cancer (28 in remission and 29 with active breast cancer) and 13 healthy women.


RESULTS
In patients with active breast cancer, plasma APP levels were significantly elevated compared to those of other groups (P<0.05). In addition, we observed a poor but positive correlation between plasma levels of APP and those of CA 15-3 (r=0.24; P=0.038). Plasma TAT levels, which reflect the activation of thrombin, were also significantly elevated in patients with active breast cancer (P<0.01), and there was a significant correlation between CA 15-3 and TAT (r=0.24; P=0.041).


CONCLUSIONS
We demonstrated that increased APP and TAT levels might reflect enhanced activation of coagulation and the fibrinolytic system in patients with active breast cancer.
Bayindir Tip Merkezi, Medical Center, Department of Internal Medicine, Ankara, Turkey.
O
O
Ozyilkan
E
E
Baltali
O
O
Ozdemir
G
G
Tekuzman
S
S
Kirazli
D
D
Firat
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000990:Antithrombin III / Q000378:metabolism*; D001778:Blood Coagulation Disorders / Q000097:blood / Q000209:etiology* / Q000276:immunology; D001943:Breast Neoplasms / Q000097:blood* / Q000150:complications* / Q000276:immunology; D005260:Female; D005341:Fibrinolysin / Q000378:metabolism*; D006801:Humans; D016014:Linear Models; D008875:Middle Aged; D018396:Mucin-1 / Q000097:blood; D010447:Peptide Hydrolases / Q000378:metabolism*; D000979:alpha-2-Antiplasmin / Q000378:metabolism*
D018396:Mucin-1; D000979:alpha-2-Antiplasmin; C046193:antithrombin III-protease complex; D000990:Antithrombin III; D010447:Peptide Hydrolases; D005341:Fibrinolysin