Phenylbutazone prevents the endotoxin-induced delay in gastric emptying in horses.
The effect of phenylbutazone on gastric emptying in horses was determined by measuring serum concentrations of acetaminophen. Gastric emptying was determined in normal fasted horses (n = 6), horses given endotoxin intravenously (n = 6), horses given intravenous phenylbutazone (n = 6), and horses given intravenous phenylbutazone plus endotoxin (n = 6). The mean time to reach maximum serum acetaminophen concentration (Tmax), the maximum serum concentration (Cmax), and the area under the serum acetaminophen concentration versus time curve (AUC) were compared among treatment groups. Phenylbutazone did not alter gastric emptying in normal horses. Endotoxin caused a profound delay in gastric emptying, and pretreatment with phenylbutazone abolished this effect.
Valk
N
N
Department of Large Animal Clinical Sciences, University of Tennessee, College of Veterinary Medicine, Knoxville 37901-1071, USA.
Doherty
T J
TJ
Blackford
J T
JT
Abraha
T W
TW
Frazier
D L
DL
D000082:Acetaminophen / Q000493:pharmacokinetics*; D000818:Animals; D004731:Endotoxins / Q000008:administration & dosage / Q000633:toxicity*; D004926:Escherichia coli; D005215:Fasting; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D006736:Horses; D007275:Injections, Intravenous; D008657:Metabolic Clearance Rate; D010653:Phenylbutazone / Q000008:administration & dosage / Q000494:pharmacology*
D004731:Endotoxins; D000082:Acetaminophen; D010653:Phenylbutazone