Eosinophil-active chemokines: assessment of in vivo activity.
The selective recruitment of eosinophils in tissue is a striking feature of allergic diseases. Recently, a family of chemoattractant molecules, namely chemokines, has been described which potently activates eosinophil function in vitro. We have developed a murine model of eosinophil recruitment to compare the relative potency and efficacy of chemokines in vivo. Of the chemokines tested, only eotaxin and MIP-1 alpha induced significant accumulation of eosinophils in vivo, but eotaxin was more effective than MIP-1 alpha. Chemokines, especially eotaxin acting via the CCR-3 receptor, may have a fundamental role in determining selective eosinophil recruitment in vivo.
Departamento de Farmacologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil. mmtex@mono.icb.ufmg.br
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Teixeira
D000818:Animals; D018925:Chemokines / Q000502:physiology*; D004804:Eosinophils / Q000502:physiology*; D051379:Mice; D019707:Receptors, Chemokine / Q000502:physiology
D018925:Chemokines; D019707:Receptors, Chemokine