[Mass spectrometry in the verification of pyrimethamine poisoning].
A 17 years old male patient with Pyrimethamin therapy was released from our department by emphasising the necessity of continuous control. A month later the patient was accepted again with serious anaemia. Since the patient did not follow the instructions Pyrimethamin intoxication was presumed, but it had to be proved. At last the drug in the plasma was identified and quantified by mass spectrometry. The plasma concentration of Pyrimethamin was five times higher than the therapeutic level. The rapid analysis (4 hours after taking of blood) and adequate treatment resulted in rapid improvement with the concomitant decrease of plasma Pyrimethamin concentration. During clinical treatment the level of Pyrimethamin in the plasma was followed by mass spectrometry.
Magyar Tudományos Akadémia, Központi Kémiai Kutató Intézet, Budapest.
L
L
Vereczkey
M
M
Klátyilc
Z
Z
Bárdosi
K
K
Jemnitz
K
K
Vékey
D000293:Adolescent; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000506:poisoning / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D062787:Drug Overdose; D006801:Humans; D008297:Male; D011041:Poisoning / Q000097:blood / Q000175:diagnosis / Q000628:therapy; D011739:Pyrimethamine / Q000008:administration & dosage / Q000097:blood / Q000506:poisoning*; D013053:Spectrophotometry; D014123:Toxoplasmosis / Q000175:diagnosis* / Q000188:drug therapy
D000890:Anti-Infective Agents; D011739:Pyrimethamine