Molecular mimicry in Guillain-Barré syndrome.
Guillain-Barré syndrome (GBS) is the commonest cause of acute flaccid paralysis worldwide. Recent pathological and electrodiagnostic studies indicated that there are different patterns within this syndrome. The demyelinating pattern predominates in North America and Europe, whereas axonal variants of GBS occur more frequently in Northern China. Infection with Campylobacter jejuni is one of the most frequently recognized antecedent events in all variants of GBS. The lipopolysaccharides of these organisms share ganglioside-like epitopes with peripheral nerves, and patients with GBS have antiganglioside antibodies. These observations have given rise to the hypothesis that "molecular mimicry" is the immunopathogenic mechanism of injury to peripheral nerve fibers. With this hypothesis in view, we summarize our experience of GBS as it occurs in Northern China. To explore the role of molecular mimicry in this cohort we sought evidence of preceding Campylobacter infection and correlated this with clinical characteristics and antiganglioside serology. Based on our results we propose a sequence of pathogenic events leading to peripheral nerve injury in GBS.
Sheikh
K A
KA
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA. Ksheikh@welchlink.welch.jhu.edu
Ho
T W
TW
Nachamkin
I
I
Li
C Y
CY
Cornblath
D R
DR
Asbury
A K
AK
Griffin
J W
JW
McKhann
G M
GM
D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D002169:Campylobacter Infections / Q000150:complications; D016123:Campylobacter jejuni; D002648:Child; D002675:Child, Preschool; D002681:China; D003967:Diarrhea / Q000276:immunology / Q000382:microbiology; D000939:Epitopes / Q000032:analysis; D005732:Gangliosides / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D007223:Infant; D008070:Lipopolysaccharides / Q000737:chemistry / Q000276:immunology*; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D010525:Peripheral Nerves / Q000276:immunology / Q000473:pathology; D011129:Polyradiculoneuropathy / Q000453:epidemiology / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D012189:Retrospective Studies; D012621:Seasons
D001323:Autoantibodies; D000939:Epitopes; D005732:Gangliosides; D008070:Lipopolysaccharides