Myocardial fatty acid metabolism in diabetic mice with 125I-BMIPP.
In patients with diabetes mellitus, the existence of diabetic cardiomyopathy was substantiated. This study was undertaken to evaluate the myocardiac fatty acid metabolism of diabetic mice (n = 21) and controls (n = 21) in 125I-BMIPP in fasted and unfasted states. 125I-BMIPP of 370 kBq was given and thirty minutes later, animals from both groups were killed. Samples of hearts, liver and other organs were removed, weighed and then counted in a scintillation counter. The percent injected dose/g of hearts of diabetic mice was significantly reduced compared to controls in unfasted (p < 0.05) and fasted (p < 0.01) groups. These findings may reflect impaired fatty acid utilization of the hearts in diabetic mice compared to controls.
Oshima
M
M
Department of Radiology, Teikyo University School of Medicine, Tokyo, Japan.
Higashi
S
S
Kikuchi
Y
Y
Shirai
T
T
Yokokawa
T
T
Kaminaga
T
T
Yasukochi
H
H
Furui
S
S
D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D004435:Eating; D005215:Fasting; D005227:Fatty Acids / Q000378:metabolism* / Q000493:pharmacokinetics*; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D007462:Iodobenzenes / Q000493:pharmacokinetics*; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D009206:Myocardium / Q000378:metabolism*; D012016:Reference Values; D012588:Scintillation Counting; D014018:Tissue Distribution
D005227:Fatty Acids; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; C049338:iodofiltic acid