Differential expression of insulin receptor tyrosine kinase inhibitor (fetuin) gene in a model of diet-induced obesity.
The Differential Display technique has been used to identify differences in mRNA expression in adipose tissue after the introduction of a high fat diet to two strains of rat (OM and S5B/PI) that differ in their susceptibility to develop obesity on this diet. The insulin receptor tyrosine kinase inhibitor protein (fetuin) was shown to be differentially expressed in OM but not S5B/PI rats. This circulating protein may play a role in the development of peripheral insulin resistance associated with high fat diets.
Lin
X
X
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA.
Braymer
H D
HD
Bray
G A
GA
York
D A
DA
D000818:Animals; D001483:Base Sequence; D018076:DNA, Complementary / Q000378:metabolism; D004041:Dietary Fats / Q000008:administration & dosage*; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D008099:Liver / Q000378:metabolism; D008297:Male; D008969:Molecular Sequence Data; D009765:Obesity / Q000209:etiology / Q000235:genetics* / Q000378:metabolism*; D010766:Phosphorylation; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011972:Receptor, Insulin / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000509:alpha-Fetoproteins / Q000096:biosynthesis* / Q000235:genetics
D018076:DNA, Complementary; D004041:Dietary Fats; D012333:RNA, Messenger; D000509:alpha-Fetoproteins; D011972:Receptor, Insulin