Endocytosis and intracellular sorting of receptor tyrosine kinases.
Binding of the peptide growth factors (GF) on their surface receptors triggers rapid endocytosis of ligand-receptor complexes via clathrin-coated pits. Internalized receptors pass through the endosomal compartment where they are efficiently sorted to the lysosomal degradation pathway. Accelerated internalization and degradation of GF receptors leads to dramatic down-regulation of the receptors. Hence, we discuss the pathways, molecular mechanisms and the biological role of the GF-induced receptor endocytosis and lysosomal targeting. The endocytosis of epidermal growth factor (EGF) receptor is employed as a model system to describe the role of clathrin, clathrin adaptors and other proteins in the recruitment of receptors into coated pits and in the endosomal sorting process.
Alexander
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Department of Pharmacology, University of Colorado Health Sciences Center, Denver, CO 80262, USA. alexander.sorkin@uchsc.edu
D004705:Endocytosis / Q000502:physiology*; D042541:Intracellular Space / Q000378:metabolism*; D021381:Protein Transport / Q000502:physiology; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*
D020794:Receptor Protein-Tyrosine Kinases