Functional genomics in the post-genome era.
As the biomedical research community enters the post-genome era, studying gene expression patterns and phenotypes in model organisms will be an important part of analyzing the role of genes in human health and disease. New technologies involving DNA chips will improve the ability to evaluate the differential expression of a large number of genes simultaneously. Also, new approaches for generating mutations in mice will significantly decrease the cost and increase the rate of generating mutant lines that model human disease.
Department of Pediatrics, Case Western Reserve University, Cleveland, OH 44106, USA. rpw@po.cwru.edu
R P
RP
Woychik
M L
ML
Klebig
M J
MJ
Justice
T R
TR
Magnuson
E D
ED
Avner
E D
ED
Avrer
D000483:Alleles; D000818:Animals; D015374:Biosensing Techniques; D005786:Gene Expression Regulation; D005796:Genes / Q000502:physiology; D016678:Genome; D006801:Humans; D008967:Molecular Biology / Q000379:methods / Q000639:trends; D016297:Mutagenesis, Site-Directed; D010641:Phenotype