Genomic strategies for defining and dissecting developmental and physiological pathways.
A major challenge in genetics research is defining and dissecting the diversity of developmental and physiological pathways that lie between genes and traits. New functional genomics methods are transforming these studies by providing comprehensive and systematic approaches that complement traditional methods of formal genetics, biochemistry, and cell biology. Together, these complementary approaches will test whether reductionism can account for the complex web of interactions that lead from genetic variation to morphological, physiological, and behavioral traits in health and disease.
Nadeau
J H
JH
Genetics Department, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-4955, USA. jhn4@po.cwru.edu
Dunn
P J
PJ
D000818:Animals; D005796:Genes / Q000235:genetics; D030342:Genetic Diseases, Inborn / Q000235:genetics; D015894:Genome, Human; D006801:Humans; D009369:Neoplasms / Q000235:genetics; D017422:Sequence Analysis, DNA