Comparison of three composite compliance indices in a trial of self-administered preventive therapy for tuberculosis in HIV-infected Ugandan adults. Uganda-Case Western Reserve University Research Collaboration.
Compliance with tuberculosis preventive therapy in a randomized placebo-controlled trial in 2736 HIV-infected Ugandans was measured using urinary isoniazid metabolite testing, clinic attendance, and self-report. Overall, 77% of urine tests were positive, subjects kept 85% of their scheduled visits while on therapy, and 69% reportedly never forgot to take their medication. Different strategies were used for constructing three composite compliance indices in active arms: (1) an unweighted index of the summed scores on scaled compliance measures; (2) a weighted index using weights obtained from a survey of experts on tuberculosis; and (3) a statistically weighted index using principal components analysis. Composite indices were evaluated for reliability, validity, and practical utility. Understanding of the regimen, study arm, subsequent follow-up, tuberculosis status, and urine spot-check result were associated with composite compliance scores. The unweighted index in this study performed as well as the weighted indices.
Pekovic
V
V
Department of Medicine, Case Western Reserve University and University Hospitals of Cleveland, Ohio 44106-4984, USA.
Mayanja
H
H
Vjecha
M
M
Johnson
J
J
Okwera
A
A
Nsubuga
P
P
Mugerwa
R
R
Ellner
J
J
Whalen
C
C
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy* / Q000652:urine*; D000328:Adult; D000553:Ambulatory Care / Q000706:statistics & numerical data*; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000652:urine*; D008297:Male; D010349:Patient Compliance; D016032:Randomized Controlled Trials as Topic; D015203:Reproducibility of Results; D012646:Self Administration / Q000592:standards*; D011795:Surveys and Questionnaires / Q000592:standards*; D014376:Tuberculosis / Q000188:drug therapy* / Q000652:urine*; D014454:Uganda
D007538:Isoniazid