GDNF protects the cochlea against noise damage.
Glial-derived neurotrophic factor (GDNF) was tested for its ability to prevent hearing and sensory cell loss in guinea pigs exposed to acoustic trauma. Hearing was measured prior to any treatment. Animals were exposed to damaging levels of noise either before or after local application of GDNF to one ear. Four weeks later, hearing and sensory cell loss was greater in the control ear than in the ear receiving GDNF before acoustic trauma or 2 h after trauma, but not 4 or 6 h after trauma. The results indicate that GDNF treatment in vivo can prevent cochlear sensory cell damage and hearing loss if present during or shortly after acoustic trauma.
Department of Otolaryngology, University of California, San Diego Medical School, La Jolla 92093-0666, USA.
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Keithley
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Ma
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Ryan
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Louis
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Magal
D000818:Animals; D001309:Auditory Threshold / Q000187:drug effects / Q000502:physiology; D003051:Cochlea / Q000293:injuries* / Q000473:pathology; D005260:Female; D051100:Glial Cell Line-Derived Neurotrophic Factor; D006168:Guinea Pigs; D018069:Hair Cells, Vestibular / Q000187:drug effects; D006317:Hearing Loss, Noise-Induced / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D009410:Nerve Degeneration / Q000473:pathology / Q000517:prevention & control; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins / Q000494:pharmacology*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D013997:Time Factors
D051100:Glial Cell Line-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D018696:Neuroprotective Agents