The pharmacology of post-trial memory processing in septum.
The septum is recognized as important in learning and memory, but relatively little is known about the role of specific neurotransmitter receptors in memory processing in the septum. We evaluated the role of the classical neurotransmitters in mice that were prepared for intraseptal microinfusion of drug solution after footshock avoidance training in T-maze. Retention for the footshock training was determined 1 week after training and drug administration. The results indicated that receptor agonists of dopamine, norepinephrine, glutamate and acetylcholine improved retention, while the antagonists impaired retention. Receptor agonists of serotonin, gamma-amino butyric acid (GABA) and opioids impaired retention, while antagonists improved retention.
Geriatric Research Education and Clinical Center, St. Louis, MO 63106, USA. jff31545@aol.com
J F
JF
Flood
S A
SA
Farr
K
K
Uezu
J E
JE
Morley
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D002395:Catecholamines / Q000494:pharmacology; D018698:Glutamic Acid / Q000494:pharmacology; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D009294:Narcotics / Q000494:pharmacology; D018377:Neurotransmitter Agents / Q000502:physiology*; D012688:Septum Pellucidum / Q000187:drug effects / Q000502:physiology*; D012701:Serotonin / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D002395:Catecholamines; D009294:Narcotics; D018377:Neurotransmitter Agents; D012701:Serotonin; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D000109:Acetylcholine