[The estimation of the level of mutations at the glycophorin A locus in subjects exposed to the chronic action of ionizing radiation].
11 persons, who had been irradiated chronically at low dose rate under occupational conditions in 1950s in doses 220-581 cGy according data of individual film dosimeters, and 5 control persons were examined regarding the level of glycophorin A (GPA) mutation type NO and NN in blood erythrocytes. Significantly higher level of GPA mutations type NO was registered in average in the group of exposed persons (23.2 +/- 4.6 x 10(-6)) compared with the control group (10.2 +/- 2.1 x 10(-6)) through the dose dependence was expressed slightly. The coefficient of the linear regression has equaled (2.3 +/- 1.2 x 10(-6)) Gy. The outlook on GPA assay usage in retrospective biodosimetry is discussed.
State Research Center of Russia, Institute of Biophysics, Moscow. rozhd@glas.apc.org
L M
LM
Rozhdestvenskiĭ
N D
ND
Okladnikova
T N
TN
Smirnova
V I
VI
Tel'nov
P G
PG
Pleshanov
P
P
Kato
R G
RG
Langlois
D000368:Aged; D002908:Chronic Disease; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005434:Flow Cytometry; D006021:Glycophorins / Q000235:genetics* / Q000528:radiation effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D009784:Occupational Diseases / Q000097:blood / Q000235:genetics*; D011832:Radiation Injuries / Q000097:blood / Q000235:genetics*; D012044:Regression Analysis; D012189:Retrospective Studies; D013997:Time Factors
D006021:Glycophorins