Use of insulin lispro in the outpatient management of ketonuria.
OBJECTIVE
To compare the effectiveness of the use of insulin lispro with the use of regular insulin in managing children with diabetes in outpatient settings.


METHODS
In this prospective study, telephone records of 75 children treated for ketonuria were analyzed. Outcome was based on the number of successful home treatment episodes (hospitalization not required), the amount of insulin the patients needed, and the time to resolution of ketonuria.


RESULTS
Doses of supplemental insulin used to treat patients with both moderate and large urine ketone values were similar (P>.05) in the insulin lispro and regular insulin groups. Likewise, the time to resolution of moderate or large ketonuria was not statistically different (P>.05) between the 2 groups. No hospitalizations were required for any of the patients for whom management via telephone was attempted.


CONCLUSIONS
These data indicate that insulin lispro is an effective option for the outpatient management of ketonuria.
Department of Pharmacy, Children's Hospital, Denver, Colo, USA.
M T
MT
Travaglini
S K
SK
Garg
H P
HP
Chase
D000293:Adolescent; D000553:Ambulatory Care; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000188:drug therapy / Q000652:urine*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007223:Infant; D007328:Insulin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D061268:Insulin Lispro; D007657:Ketone Bodies / Q000652:urine*; D007662:Ketosis / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D011446:Prospective Studies
D007004:Hypoglycemic Agents; D007328:Insulin; D061268:Insulin Lispro; D007657:Ketone Bodies