Protective effects of an antiulcer agent, ecabet sodium on colorectal carcinogenesis in rodents.
A new antiulcer agent, ecabet sodium is one of dehydroabietic acid derivatives prepared from pine resin. The effects of ecabet sodium on colorectal carcinogenesis were investigated in azoxymethane-pretreated mice with chronic ulcerative colitis induced by 3 repeated administration of 3% dextran sulfate sodium and in 1, 2-dimethylhydrazine-treated rats. Although daily treatment with ecabet sodium did not affect the colorectal DNA-synthesizing enzyme activities and bromodeoxyuridine-immunoreactive S-phase cells, high-grade dysplasia in ecabet sodium-treated mice was less frequent than in untreated mice. In rats, ecabet sodium administration reduced the elevated activity of thymidylate synthetase in colorectal tumors.
Yarimizu
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T
Third Internal Medicine, Oita Medical University, Oita 879-55, Japan.
Mitamura
T
T
Suzuki
S
S
Sakamoto
S
S
D019813:1,2-Dimethylhydrazine; D045784:Abietanes; D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D001397:Azoxymethane; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens; D003093:Colitis, Ulcerative / Q000139:chemically induced / Q000150:complications*; D003106:Colon / Q000187:drug effects / Q000473:pathology; D015179:Colorectal Neoplasms / Q000139:chemically induced / Q000201:enzymology / Q000473:pathology / Q000517:prevention & control*; D004224:Diterpenes / Q000627:therapeutic use*; D005260:Female; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009929:Organ Size / Q000187:drug effects; D011230:Precancerous Conditions / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control; D051381:Rats; D011919:Rats, Inbred Strains; D012007:Rectum / Q000187:drug effects / Q000473:pathology; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors / Q000096:biosynthesis
D045784:Abietanes; D016588:Anticarcinogenic Agents; D002273:Carcinogens; D004224:Diterpenes; C061681:ecabet; D013940:Thymidylate Synthase; D019813:1,2-Dimethylhydrazine; D001397:Azoxymethane