A novel testis-specific gene, SPAG4, whose product interacts specifically with outer dense fiber protein ODF27, maps to human chromosome 20q11.2.
The product of the spermatid-specific rat SPAG4 gene interacts specifically with the major 27-kDa outer dense fiber protein ODF27 in elongating spermatids. In this study we isolated the human homolog of the spermatid-specific rat SPAG4 gene and mapped it by fluorescence in situ hybridization to chromosome 20q11.2.
Department of Medical Biochemistry, Southern Alberta Cancer Research Centre, University of Calgary, Calgary, Alberta (Canada).
H
H
Tarnasky
D
D
Gill
S
S
Murthy
X
X
Shao
D J
DJ
Demetrick
F A
FA
van der Hoorn
D001483:Base Sequence; D002352:Carrier Proteins; D002874:Chromosome Mapping; D002890:Chromosomes, Human, Pair 20 / Q000235:genetics*; D015342:DNA Probes / Q000235:genetics; D018076:DNA, Complementary / Q000235:genetics; D015723:Gene Library; D005796:Genes / Q000235:genetics*; D006360:Heat-Shock Proteins; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008565:Membrane Proteins; D008969:Molecular Sequence Data; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D013737:Testis / Q000378:metabolism*
D002352:Carrier Proteins; D015342:DNA Probes; D018076:DNA, Complementary; D006360:Heat-Shock Proteins; D008565:Membrane Proteins; C086058:ODF1 protein, human; C490108:Odf1 protein, rat; D011506:Proteins; C114799:SPAG4 protein, human; C485434:Spag4 protein, rat