Swellable microparticles containing Suprofen: evaluation of in vitro release and photochemical behaviour.
Suprofen, an anti-inflammatory drug was incorporated in polymer networks based on biocompatible macromolecules, such as alpha,beta-polyasparthydrazide (PAHy) and alpha,beta-poly(N-hydroxyethyl)-DL-aspartamide (PHEA) crosslinked by glutaraldehyde or gamma-rays, respectively. Swelling tests carried out in aqueous media showed that pH value affects the swelling degree of the prepared hydrogels. In vitro release tests were performed in simulated gastrointestinal fluids (pH 1/6.8) using the pH variation method and in phosphate-buffered saline, pH 7.4. Experimental data indicated that Suprofen was released in a sustained way both from PAHy and PHEA microparticles. Further, incorporation of Suprofen in PAHy and PHEA networks provided a significant reduction of the drug photosensitizing activity, as evidenced by in vitro hemolysis tests.
Dipartimento di Chimica e Tecnologie Farmaceutiche, Università di Palermo, Italy. gaegiamm@mbox.unipa.it
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D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000494:pharmacology; D003432:Cross-Linking Reagents / Q000737:chemistry; D003692:Delayed-Action Preparations; D004912:Erythrocytes / Q000187:drug effects; D005750:Gastric Juice / Q000378:metabolism; D005782:Gels; D005976:Glutaral / Q000737:chemistry; D006461:Hemolysis; D006801:Humans; D006834:Hydrazines / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D009757:Nylons / Q000737:chemistry; D010316:Particle Size; D010455:Peptides / Q000737:chemistry; D017319:Photosensitizing Agents / Q000737:chemistry*; D010952:Plasma Substitutes; D013496:Suprofen / Q000737:chemistry* / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D005782:Gels; D006834:Hydrazines; D009757:Nylons; D010455:Peptides; D017319:Photosensitizing Agents; D010952:Plasma Substitutes; C008965:alpha,beta-poly((2-hydroxyethyl)-aspartamide); C114303:alpha,beta-polyasparthydrazide; D013496:Suprofen; D005976:Glutaral