Antimicrobial susceptibility of subgingival bacterial flora in dogs with gingivitis.
The aerobic and anaerobic flora from gingival pockets of 49 dogs with severe gingivitis and periodontitis were cultured. The susceptibility of each isolate to four antimicrobial agents currently approved for veterinary use in the USA (amoxicillin-clavulanic acid; clindamycin; cefadroxil; and enrofloxacin) was determined. Amoxicillin-clavulanic acid (Clavamox Pfizer Animal Health) had the highest in-vitro susceptibility against all isolates (96%), all aerobes (94%) and all anaerobes (100%) tested. For gram-negative aerobes, enrofloxacin (Baytril, Bayer Corp.) had the highest in-vitro susceptibility activity. For bacteria associated with treatment of gingivitis, which typically are mixed aerobic/anaerobic and gram-positive/gram-negative organisms, the antimicrobial of choice for clinical use based on these susceptibility tests is amoxicillin-clavulanic acid.
Veterinary Hospital of the University of Pennsylvania, Philadelphia 19104, USA.
C E
CE
Harvey
C
C
Thornsberry
B R
BR
Miller
F S
FS
Shofer
D019980:Amoxicillin-Potassium Clavulanate Combination / Q000494:pharmacology / Q000627:therapeutic use; D000704:Analysis of Variance; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D000890:Anti-Infective Agents; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D002434:Cefadroxil / Q000494:pharmacology / Q000627:therapeutic use; D002981:Clindamycin / Q000494:pharmacology / Q000627:therapeutic use; D004283:Dog Diseases / Q000382:microbiology*; D004285:Dogs; D000077422:Enrofloxacin; D024841:Fluoroquinolones; D005891:Gingivitis / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D008826:Microbial Sensitivity Tests / Q000662:veterinary; D010514:Periodontal Pocket / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D015363:Quinolones / Q000494:pharmacology / Q000627:therapeutic use; D018709:Statistics, Nonparametric
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; D002434:Cefadroxil; D000077422:Enrofloxacin; D002981:Clindamycin; D019980:Amoxicillin-Potassium Clavulanate Combination