Does dextran 40 improve the early patency of autogenous infrainguinal bypass grafts?
OBJECTIVE
We determined whether the administration of dextran 40 would increase the early (30-day) patency of autogenous infrainguinal bypass grafts.


METHODS
During a 4-year period, 244 patients undergoing 273 autogenous infrainguinal bypass grafts were prospectively enrolled into and completed this study. Patients were randomized into two groups; one of the groups received a 72-hour infusion of dextran 40 after surgery, and the other did not. Comparisons were made between those patients who did and did not receive dextran 40 with respect to risks factors, demographics, and early graft patency.


RESULTS
One hundred twenty-six procedures were accompanied by the use of dextran; 147 were not. There was no significant difference between the two groups with respect to patient age, gender, perioperative risk factors, indication for surgery, or location of bypass graft (popliteal vs tibial). Among those patients receiving dextran, there were eight early occlusions (6.4%) and four deaths (3.2%); 89.7% of the patients were alive with patent grafts 30 days after surgery. In the group not receiving dextran, there were 10 early occlusions (6.8%) and 3 deaths (2%); 90.5% of the patients were alive with patent grafts 30 days after surgery. There was no significant difference between the two groups with respect to rate of early occlusion (p = 1.00), death (p = 0.71), or 30-day patency (p = 0.84).


CONCLUSIONS
The administration of dextran 40 does not increase the early patency of autogenous infrainguinal bypass grafts. Its routine use during these procedures cannot be recommended.
Huntington Memorial Hospital, Pasadena, Calif, USA.
S G
SG
Katz
R D
RD
Kohl
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000627:therapeutic use*; D001157:Arterial Occlusive Diseases / Q000601:surgery*; D003911:Dextrans / Q000627:therapeutic use*; D006083:Graft Occlusion, Vascular / Q000209:etiology; D006119:Groin; D006801:Humans; D008875:Middle Aged; D011150:Popliteal Artery / Q000601:surgery; D011446:Prospective Studies; D012307:Risk Factors; D012501:Saphenous Vein / Q000637:transplantation*; D017211:Treatment Failure; D014654:Vascular Patency
D000925:Anticoagulants; D003911:Dextrans