[Cerebrospinal fluid sorption in patients with heroin addiction].
The sorption of cerebrospinal fluid (CSF) was attempted as a special detoxifying procedure in a group of sixty heroine addicts. CSF contents of cells, total protein, nucleic acids and interleukin-1 (IL-1), as well as acridine orange (AO) binding to CSF cells were determined before and after the procedure. The treatment provided immediate clinical improvement for 70% of the patients. Clinical effect was accompanied by decreased of CSF cells, diminished nucleic acids and protein amounts, along with increased DNA-AO binding and accumulation of IL-l. These data are interpreted in terms of intensive apoptosis of CSF cells and increased acute phase of aseptic inflammation-like events induced by the procedure of liquor sorption.
N G
NG
Mikhaĭlova
A M
AM
Reshchikov
S V
SV
Tokalov
K P
KP
Khanson
N V
NV
Kornilov
A S
AS
Iagunov
A B
AB
Chukhlovin
D002555:Cerebrospinal Fluid / Q000737:chemistry* / Q000166:cytology / Q000276:immunology; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D004247:DNA / Q000032:analysis; D005069:Evaluation Studies as Topic; D005453:Fluorescence; D006556:Heroin Dependence / Q000134:cerebrospinal fluid / Q000628:therapy*; D006801:Humans; D012313:RNA / Q000032:analysis; D012397:Rosette Formation; D016060:Sorption Detoxification
D002556:Cerebrospinal Fluid Proteins; D012313:RNA; D004247:DNA