A lasting change in trazodone response after non-convulsive electroshock therapy for medication-resistant senile depression.
A senile patient showed a dramatic recovery from medication-resistant depression after non-convulsive electroshock therapy (nc-EST), with a lasting change in response to trazodone, which mainly acts as a serotonin re-uptake inhibitor. This result suggests that a change in the serotonin reuptake mechanism may be involved in the effect of nc-EST on depression.
Department of Psychiatry, Tohoko University School of Medicine, Sendai, Japan.
H
H
Shen
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S
Awata
M
M
Konno
M
M
Sato
D000368:Aged; D018687:Antidepressive Agents, Second-Generation / Q000008:administration & dosage* / Q000009:adverse effects; D003131:Combined Modality Therapy; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D004565:Electroconvulsive Therapy; D005625:Frontal Lobe / Q000098:blood supply; D006801:Humans; D008297:Male; D012039:Regional Blood Flow / Q000187:drug effects; D015899:Tomography, Emission-Computed, Single-Photon; D014196:Trazodone / Q000008:administration & dosage* / Q000009:adverse effects; D016896:Treatment Outcome
D018687:Antidepressive Agents, Second-Generation; D014196:Trazodone