NMR methods in combinatorial chemistry.
The use of NMR spectroscopy in combinatorial chemistry has provided a versatile tool for monitoring combinatorial chemistry reactions and for assessing ligand-receptor interactions. The application of magic angle spinning NMR is widespread and has allowed structure determination to be performed on compounds attached to solid supports. A variety of two-dimensional NMR techniques have been applied to enhance the usability of the magic angle spinning NMR data. New developments for solution NMR analysis include high performance liquid chromatography, NMR, mass spectroscopy and flow NMR. NMR based methods currently being investigated may prove valuable as compound screening tools.
Department of Analytics, Novartis Pharmaceuticals Corporation, Summit, NJ 07901, USA. michael.shapiro@pharma.novartis.com
M J
MJ
Shapiro
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Wareing
D002625:Chemistry, Organic / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D007202:Indicators and Reagents; D013058:Mass Spectrometry; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*; D012116:Resins, Plant; D012996:Solutions
D007202:Indicators and Reagents; D012116:Resins, Plant; D012996:Solutions