The -514 polymorphism in the hepatic lipase gene (LIPC) does not influence androgen-mediated stimulation of hepatic lipase activity.
The -514T allele of hepatic lipase is associated with increased high density lipoprotein-cholesterol levels in men, but not in women. This observation suggests that the -514C to T polymorphism may diminish the response of hepatic lipase to androgens. To test this hypothesis, five -514T and five -514C homozygous men were treated with the anabolic steroid stanozolol for 6 days. The mean increase in hepatic lipase activity was similar in the two groups (45+/-10 vs. 51+/-10 mmol x hr(-1) x l(-1), P = 0.5). To evaluate the association between the -514 polymorphism and hepatic lipase activity at different physiological androgen concentrations, hepatic lipase genotypes and activities were measured in 44 men and 40 premenopausal women. The effect of the -514T allele on hepatic lipase activity was significant and quantitatively similar in both sexes. These data indicate that the -514 polymorphism does not influence the response of hepatic lipase activity to androgens, and that the effects of this polymorphism on hepatic lipase activity are independent of androgen action.
Vega
G L
GL
The Center for Human Nutrition, Department of Clinical Nutrition, University of Texas Southwestern Medical Center at Dallas, 75235, USA.
Gao
J
J
Bersot
T P
TP
Mahley
R W
RW
Verstraete
R
R
Grundy
S M
SM
White
A
A
Cohen
J C
JC
D000328:Adult; D000483:Alleles; D045930:Anabolic Agents / Q000494:pharmacology; D005260:Female; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008049:Lipase / Q000097:blood / Q000187:drug effects / Q000235:genetics*; D008099:Liver / Q000201:enzymology*; D008156:Luciferases / Q000235:genetics; D008297:Male; D015741:Metribolone / Q000494:pharmacology; D008875:Middle Aged; D011110:Polymorphism, Genetic; D017697:Premenopause; D011401:Promoter Regions, Genetic / Q000187:drug effects; D012016:Reference Values; D012727:Sex Characteristics; D013197:Stanozolol / Q000494:pharmacology
D045930:Anabolic Agents; D015741:Metribolone; D013197:Stanozolol; D008156:Luciferases; D008049:Lipase