Circadian rhythmometry of serum endogenous tumor necrosis factor-alpha in patients with colorectal cancer metastases.
The objective of this study was to test the hypothesis of a diurnal fluctuation of circulating levels of endogenous tumor necrosis factor-alpha (TNF-alpha) in patients with colorectal cancer metastases. Serum levels of TNF-alpha were measured 6 times a day in 27 colorectal cancer patients as well as in healthy controls. The levels of TNF-alpha in serum from healthy controls were close to the detection limit of the method or were not detectable at all. Serum TNF-alpha levels in advanced cancer patients were substantially increased. Peak values appeared at 2 a.m. In contrast, the levels were low in the afternoon (2 p.m). The presence of a circadian rhythm was found with the acrophase at 0 hour 40 min.
5th Departement of Internal Disease, Silesian Medical University, Bytom, Poland.
M
M
Muc-Wierzgoń
K
K
Madej
M
M
Baranowski
J
J
Wierzgoń
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D002940:Circadian Rhythm / Q000502:physiology*; D015179:Colorectal Neoplasms / Q000097:blood / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D014409:Tumor Necrosis Factor-alpha