Antiepileptic drug treatment following temporal lobectomy.
Antiepileptic drug use was documented before and after temporal lobectomy. Carbamazepine, phenytoin, and clobazam were the most commonly used drugs, both pre- and postoperatively. Preoperatively, polytherapy was used in 78% of patients; at 6 months follow-up, 47%; at 12 months, 18%; and at 24 months, 14%. Preoperatively, monotherapy was used in 20% of patients; at 6 months follow-up, 49%; at 12 months, 55%; and at 24 months, 42%. No medication was used preoperatively by 2% of patients; at 6 months follow-up, 2%; at 12 months, 27%; and at 24 months, 44% (p < 0.001). After 2 years, 53% of patients who were seizure free had stopped taking medication, as had 33% who had some seizures after surgery.
Department of Medicine, University of Manitoba, Winnipeg, Canada.
J
J
Maher
R S
RS
McLachlan
D000293:Adolescent; D000328:Adult; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants / Q000627:therapeutic use*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000627:therapeutic use; D002220:Carbamazepine / Q000627:therapeutic use*; D002541:Cerebral Decortication; D000078306:Clobazam; D003131:Combined Modality Therapy; D004833:Epilepsy, Temporal Lobe / Q000188:drug therapy* / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010672:Phenytoin / Q000627:therapeutic use; D011446:Prospective Studies
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D001570:Benzodiazepinones; D001569:Benzodiazepines; D000078306:Clobazam; D002220:Carbamazepine; D010672:Phenytoin