[The effect of zinc metallothionein on lipid peroxidation in rodent bone marrow cells].
It was shown, that rat hepatic Zn-metallothionein (Zn-MT) depressed in vitro Fe3+/ADP-induced lipid peroxidation (LP) in rat bone marrow cells and increased its viability after pro-oxidant's influences. ZnCl2 and its combination with cysteine also decreased LP products level, but less and did not alter viability. On 9-th day after gamma-irradiation (6 Gy) in mice protected with Zn-MT the LP products level in bone marrow was decreased in considerable extent.
State Research Center of Russia, Institute of Biophysics, Moscow.
A N
AN
Koterov
Z A
ZA
Trebenok
N B
NB
Pushkareva
A V
AV
Nikol'skiĭ
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D005290:Ferric Compounds / Q000494:pharmacology; D005720:Gamma Rays; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000528:radiation effects; D008668:Metallothionein / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D000975:Antioxidants; D005290:Ferric Compounds; D011837:Radiation-Protective Agents; C021267:zinc thionein; D000244:Adenosine Diphosphate; D008668:Metallothionein