[Corticoid therapy and bronchial inflammation in asthma. The use of bronchial biopsy].
The development of fibreoptic bronchoscopy has enabled significant progress in the understanding of the pathogenesis of asthma. It has brought to the fore the importance of bronchial inflammation even in asymptomatic patients and/or in patients who have only mild disease. The practice of bronchial biopsy in vivo is an excellent method of studying bronchial inflammation. The purpose of this general review is to recall the value of bronchial biopsies in the understanding of the effects of steroids on asthma: effects on the epithelium, the basement membrane and the blood vessels. Their cellular contents consist equally of cytokines, enzymes and adhesion molecules. At the level of the bronchial epithelium steroid therapy engenders a diminution in eosinophils, mast cells an lymphocytes. It restores the ratio of ciliated to other cells back to normal and increases the number of nerve synapses. Regarding the interstitium the corticoids diminish the number of eosinophils, mast cells and T lymphocytes. The effect on different lymphocyte subtypes is controversial, as is the effect of the basal membrane. Steroid therapy diminishes the proteins, GM-CSF.RANTES and IL-8 as well as the messengers IL-4, IL-13 and IL-5. It seems to increase the messengers for IFN-gamma and IL-12 and favourably modulates the vascular composition to inflammation in asthma. Nevertheless it is to be regretted that too few studies have looked at the correlations between histological changes and clinical and respiratory function improvement engendered by steroid therapy.
Jaffuel
D
D
Service des Maladies Respiratoires, INSERM U454, Hôpital Arnaud de Villeneuve, Montpellier.
Mathieu
M
M
Torado de la Fuente
P
P
Michel
F B
FB
Godard
P
P
Demoly
P
P
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy* / Q000473:pathology; D001485:Basement Membrane / Q000187:drug effects; D001706:Biopsy; D001808:Blood Vessels / Q000187:drug effects; D001980:Bronchi / Q000187:drug effects / Q000201:enzymology / Q000473:pathology*; D001991:Bronchitis / Q000188:drug therapy* / Q000473:pathology; D001999:Bronchoscopy; D015815:Cell Adhesion Molecules / Q000187:drug effects; D018946:Chemokine CCL5 / Q000378:metabolism; D004804:Eosinophils / Q000187:drug effects; D004848:Epithelium / Q000187:drug effects; D005336:Fiber Optic Technology; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000187:drug effects; D006801:Humans; D007371:Interferon-gamma / Q000187:drug effects; D007378:Interleukins / Q000378:metabolism; D016131:Lymphocyte Subsets / Q000187:drug effects; D008407:Mast Cells / Q000187:drug effects; D013569:Synapses / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects
D000305:Adrenal Cortex Hormones; D018927:Anti-Asthmatic Agents; D015815:Cell Adhesion Molecules; D018946:Chemokine CCL5; D007378:Interleukins; D007371:Interferon-gamma; D016178:Granulocyte-Macrophage Colony-Stimulating Factor