Interstitial laser coagulation: evaluation of the effect of normal liver blood perfusion and the application mode on lesion size.
OBJECTIVE
The effect of temporarily interrupted hepatic blood flow and multiple-fiber application on necrosis volume in interstitial laser coagulation (ILC) was investigated.


METHODS
Single- and multiple-fiber ILC were performed in porcine livers with normal as well as interrupted perfusion. Temperatures were determined. Lesions were measured and studied by light microscopy 4 hours post-treatment.


RESULTS
ILC with multiple-fiber application led to significantly greater individual lesion volumes (3.7 +/- 0.5 cm3) than single-fiber application (2.5 +/- 0.5 cm3) (P < .01). The interruption of hepatic perfusion led to a significant increase in lesion volume with single- (7.5 +/- 1.0 cm3) as well as multiple-fiber application (12.6 +/- 2.2 cm3) (P < .01). Superposition of the lesions in the multiple-fiber application mode was only determined with interrupted perfusion (total volume: 50.3 +/- 6.6 cm3).


CONCLUSIONS
Interruption of hepatic perfusion increases lesion volumes significantly. ILC for treating liver tumors should preferably be performed by application routes that permit temporary interruption of hepatic perfusion.
Department of Surgery, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin, Germany.
D
D
Albrecht
C T
CT
Germer
C
C
Isbert
J P
JP
Ritz
A
A
Roggan
G
G
Müller
H J
HJ
Buhr
D000818:Animals; D066298:In Vitro Techniques; D017075:Laser Coagulation / Q000009:adverse effects / Q000379:methods*; D008099:Liver / Q000098:blood supply* / Q000473:pathology / Q000601:surgery*; D008114:Liver Neoplasms, Experimental / Q000601:surgery; D009336:Necrosis; D013552:Swine