[The possible mechanism of the antiradiation effect of metallothionein: the stimulation of DNA replicative synthesis and of bone marrow cell proliferation].
Zn-MT and less apo MT (4-100 mkg/ml) in vitro stimulated the [3H]-thymidine incorporation in mice bone marrow cells, but ZnCl2, its combination with cysteine and mixture (ZnCl2 + cystine + albumin) inhibited DNA synthesis. In protected with Zn-MT (1-4 mg/kg) 10-15 min before irradiation (6 Gy) mice on 9th day after influencing the increasing of DNA replicative synthesis level and nuclear cell number in bone marrow were observed.
State Research Center of Russia, Institute of Biophysics, Moscow.
A N
AN
Koterov
Z A
ZA
Trebenok
N B
NB
Pushkareva
A V
AV
Nikol'skiĭ
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D002455:Cell Division / Q000187:drug effects / Q000528:radiation effects; D002478:Cells, Cultured; D004261:DNA Replication / Q000187:drug effects* / Q000528:radiation effects; D005720:Gamma Rays; D008668:Metallothionein / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013936:Thymidine / Q000378:metabolism / Q000528:radiation effects; D013997:Time Factors; D014316:Tritium
D011837:Radiation-Protective Agents; C021267:zinc thionein; D014316:Tritium; D008668:Metallothionein; D013936:Thymidine