Multiple solid-phase synthesis of hydantoins and thiohydantoins.
A novel general protocol for the construction of hydantoins and thiohydantoins on a solid support has been developed. Using this novel methodology, the synthesis of a diverse 96-compound library has been achieved. Resin-bound dipeptides are cyclised via the formation of an intermediate isocyanate or isothiocyanate on resin as the key step in the strategy.
Bhalay
G
G
Oxford Diversity, Division of Oxford Asymmetry Ltd., Abingdon, Oxon, UK.
Cowell
D
D
Hone
N D
ND
Scobie
M
M
Baxter
A D
AD
D016208:Databases, Factual; D006827:Hydantoins / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D013058:Mass Spectrometry; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012116:Resins, Plant; D013329:Structure-Activity Relationship; D013867:Thiohydantoins / Q000138:chemical synthesis* / Q000737:chemistry
D006827:Hydantoins; D007202:Indicators and Reagents; D012116:Resins, Plant; D013867:Thiohydantoins