The effect of environment on the changes in calmodulin in rat brain produced by repeated amphetamine treatment.
Rats were given repeated infusions of i.v. amphetamine in association with placement in a novel test environment, a protocol that produces behavioral sensitization, or in the home cage, a protocol that fails to induce sensitization. In several brain areas amphetamine altered calmodulin content, but only in the group treated in a novel environment, suggesting that amphetamine-induced alterations in calmodulin may occur only when drug treatments induce behavioral sensitization.
Neuroscience and Biopsychology Programs, Departments of Psychology and Pharmacology, The University of Michigan, 525 East University St. , Ann Arbor, MI 48109-1109, USA.
M M
MM
Ostrander
J
J
Hartman
A
A
Badiani
T E
TE
Robinson
M E
ME
Gnegy
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects* / Q000502:physiology; D002147:Calmodulin / Q000378:metabolism*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D004777:Environment; D005106:Exploratory Behavior / Q000187:drug effects*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D002147:Calmodulin; D000697:Central Nervous System Stimulants; D000661:Amphetamine