[The effect of antibiotics on the adhesion of Corynebacterium diphtheriae to buccal epithelial cells].
The model of buccal epithelium of healthy people was used to study the effect of antibiotics with different action mechanism (benzylpenicillin, ampicylin, erythromycin, streptomycin) on the adhesion intensity of diphtheria corynebacteria. It has been established that only erythromycin in minimum inhibiting concentration manifested the ability to inhibit the adhesion of different biovars of Corynebacterium diphtheriae. The drug action did not depend on the level of adhesive activity of certain cultures. Subinhibiting concentrations of erythromycin did not affect the processes of the diphtheria corynebacteria adhesion.
Hladka
O A
OA
Lviv Scientific Research Institute of Epidemiology and Hygiene, Ukraine.
Motyka
O I
OI
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001422:Bacterial Adhesion / Q000187:drug effects*; D002478:Cells, Cultured; D002610:Cheek; D003353:Corynebacterium diphtheriae / Q000187:drug effects* / Q000472:pathogenicity; D004305:Dose-Response Relationship, Drug; D004847:Epithelial Cells / Q000382:microbiology*; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods
D000900:Anti-Bacterial Agents