Treatment of male urethral strictures: is repeated dilation or internal urethrotomy useful?
OBJECTIVE
We evaluate the efficacy of repeated dilation or urethrotomy as treatment of male urethral strictures.


METHODS
Between January 1991 and January 1994, 210 men with proved urethral strictures were prospectively randomized to undergo filiform dilation (106) or internal urethrotomy (104). Followup was scheduled at 3, 6, 9, 12, 24, 36 and 48 months. Dilation or internal urethrotomy was repeated at the first and second stricture recurrence. The Kaplan-Meier method was used to estimate survivor function for the treatment methods (survival time being the time to first stricture recurrence) and the log rank test was used to compare the efficacy of different treatments.


RESULTS
Followup (mean 24 months, range 2 to 63) was available in 163 patients (78%). After a single dilation or urethrotomy not followed by re-stricturing at 3 months, the estimated stricture-free rate was 55 to 60% at 24 months and 50 to 60% at 48 months. After a second dilation or urethrotomy for stricture recurrence at 3 months the stricture-free rate was 30 to 50% at 24 months and 0 to 40% at 48 months. After a third dilation or urethrotomy for stricture recurrence at 3 and 6 months the stricture-free rate at 24 months was 0 (p <0.0001).


CONCLUSIONS
Dilation and internal urethrotomy are useful in a select group (approximately 70% of all patients) who are stricture-free at 3 months, and of whom 50 to 60% will remain stricture-free up to 48 months. A second dilation or urethrotomy for early stricture recurrence (at 3 months) is of limited value in the short term (24 months) but of no value in the long term (48 months), whereas a third repeated dilation or urethrotomy is of no value.
Department of Urology, Faculty of Medicine, University of Stellenbosch and Tygerberg Hospital, South Africa.
C F
CF
Heyns
J W
JW
Steenkamp
M L
ML
De Kock
P
P
Whitaker
D002404:Catheterization; D015331:Cohort Studies; D020684:Cystoscopes; D018572:Disease-Free Survival; D005471:Fluoroscopy; D005500:Follow-Up Studies; D006801:Humans; D016014:Linear Models; D008297:Male; D011446:Prospective Studies; D012008:Recurrence; D012086:Reoperation; D019233:Retreatment; D014513:Ureter / Q000601:surgery*; D014525:Urethral Stricture / Q000000981:diagnostic imaging / Q000601:surgery / Q000628:therapy*; D014546:Urinary Catheterization / Q000295:instrumentation