Generalized linear least squares method for fast generation of myocardial blood flow parametric images with N-13 ammonia PET.
In this paper, we developed and tested strategies for estimating myocardial blood flow (MBF) and generating MBF parametric images using positron emission tomography (PET), N-13 ammonia, and the generalized linear least square (GLLS) method. GLLS was generalized to the general linear compartment model, modified for the correction of spillover, validated using simulated N-13 ammonia data, and examined using PET data from several patient studies. In comparison to the standard model-fitting procedure, the GLLS method provided similar accuracy and superior computational speed.
PET Center, Good Samaritan Regional Medical Center, Phoenix, AZ 85006, USA. keweic@samaritan.edu
K
K
Chen
M
M
Lawson
E
E
Reiman
A
A
Cooper
D
D
Feng
S C
SC
Huang
D
D
Bandy
D
D
Ho
L S
LS
Yun
A
A
Palant
D000368:Aged; D000465:Algorithms; D000641:Ammonia; D003198:Computer Simulation; D003326:Coronary Circulation / Q000502:physiology*; D003327:Coronary Disease / Q000503:physiopathology / Q000601:surgery; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007387:Internal Mammary-Coronary Artery Anastomosis; D016018:Least-Squares Analysis; D016014:Linear Models; D008297:Male; D008955:Models, Cardiovascular; D009590:Nitrogen Radioisotopes; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D013997:Time Factors; D014055:Tomography, Emission-Computed / Q000379:methods / Q000706:statistics & numerical data
D009590:Nitrogen Radioisotopes; D019275:Radiopharmaceuticals; D000641:Ammonia