The relationship between smooth pursuit eye movements and tardive dyskinesia in schizophrenia.
OBJECTIVE
To examine the relationship between smooth pursuit eye movements and tardive dyskinesia (TD) in schizophrenia.


METHODS
Forty schizophrenic patients with TD and 25 non-TD patients had smooth pursuit eye movements tested with infrared oculography. In addition to the diagnosis of TD (present or absent), each patient had ratings of severity of TD.


RESULTS
There was no significant or strong association between TD and poor smooth pursuit eye movements.


CONCLUSIONS
The results stand in contrast to those of several previous studies, which were based on limited methodology. However, this study was not able to exclude definitively the possibility that TD is associated with poor smooth pursuit, perhaps with a small to moderate effect. Furthermore, these conclusions are limited to simple eye tracking protocols in which distractions are minimized. The question of whether or not TD is associated with poor smooth pursuit in schizophrenia needs to be resurrected.
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland at Baltimore, MD, USA. davideross@erols.com
D E
DE
Ross
R W
RW
Buchanan
A C
AC
Lahti
D
D
Medoff
J J
JJ
Bartko
A D
AD
Compton
G K
GK
Thaker
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D004409:Dyskinesia, Drug-Induced / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D011698:Pursuit, Smooth / Q000502:physiology*; D012438:Saccades / Q000502:physiology; D012559:Schizophrenia / Q000188:drug therapy / Q000503:physiopathology; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric
D014150:Antipsychotic Agents