Immune response of calves experimentally infected with non-cell-culture-passaged bovine respiratory syncytial virus.
The immune response of calves was studied following infection with non-cell-passaged Bovine respiratory syncytial virus (BRSV). Two groups of 6 specific pathogen free (SPF) calves were housed in separate isolation rooms. One group was inoculated intranasally with a non-cell-passaged BRSV strain and the control group was mock-infected. A BRSV specific antibody response was observed for all the BRSV infected calves. These antibodies were shown to have neutralizing activity. No lymphocyte proliferation response was detected in the mock-infected group whereas three animals in the infected group were positive three weeks after the infection. All BRSV-infected calves, except one, produced interferon-gamma (IFN-gamma) one week post-infection and IFN-gamma was observed in all six infected calves after three weeks. The control group showed no IFN-gamma synthesis. In spite of the limits of the BRSV infection model, humoral and cellular immune responses were actively developed by all the calves against this pathogen.
Lab. Immunologie, URBM, Facultés Universitaires Notre-Dame de la Paix, Namur, Belgium.
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I
Knott
V
V
Weynants
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K
Walravens
W H
WH
van der Poel
J A
JA
Kramps
J J
JJ
Letesson
D000818:Animals; D002417:Cattle; D007371:Interferon-gamma / Q000096:biosynthesis; D008213:Lymphocyte Activation; D018357:Respiratory Syncytial Virus Infections / Q000276:immunology*; D018112:Respiratory Syncytial Virus, Bovine
D007371:Interferon-gamma