Causative role of oxyradicals in myocardial stunning: a proven hypothesis. A brief review of the evidence demonstrating a major role of reactive oxygen species in several forms of postischemic dysfunction.
Whether or not ROS are the actual initiator or a downstream mediator of stunning, the theory that they play a major causative role in this phenomenon is now a proven hypothesis. ROS play a prominent role in multiple forms of stunning. Furthermore, the role of ROS is prominent not only in open-chest models but also in conscious animal preparations. The major challenge for future studies will be to identify the specific molecular targets of ROS-mediated damage and to decipher the pathways whereby ROS and calcium interact in the genesis of myocardial stunning.
Bolli
R
R
Division of Cardiology, University of Louisville, Kentucky 40292, USA. rÿbollÿ1@ulkyvm.louisville.edu
D000818:Animals; D006801:Humans; D009200:Myocardial Contraction; D017682:Myocardial Stunning / Q000209:etiology* / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*
D017382:Reactive Oxygen Species