[Biochemical markers enable early diagnosis of myocardial damage].
Diagnosis of myocardial damage based on early measurement of biochemical markers is becoming an increasingly important guide in the management and treatment of suspected coronary artery disease. The new, more sensitive and/or specific markers myoglobin, CK-MB (creatine kinase and its cardiospecific isoenzyme), and the troponins T and I, are reviewed in the article, new rapid analytical tests are discussed, and modified sampling routines proposed. The combination of a marker with high early sensitivity and a marker with a broad time window and high specificity, together with modified sampling routines and analysis of whole blood can yield a reliable diagnosis within minutes or (3-6) hours of the patient's presentation. Moreover, together with other non-invasive methods, use of the markers of myocardial injury enables rapid and reliable risk analysis.
Lindahl
B
B
Kardiologkliniken, Akademiska sjukhuset, Uppsala.
Gerhardt
W
W
D000789:Angina, Unstable / Q000175:diagnosis / Q000201:enzymology / Q000378:metabolism; D015415:Biomarkers / Q000032:analysis*; D003327:Coronary Disease / Q000175:diagnosis* / Q000201:enzymology / Q000378:metabolism; D003402:Creatine Kinase / Q000097:blood; D006801:Humans; D007527:Isoenzymes; D009203:Myocardial Infarction / Q000175:diagnosis / Q000201:enzymology / Q000378:metabolism; D009211:Myoglobin / Q000097:blood; D012680:Sensitivity and Specificity; D013048:Specimen Handling; D013997:Time Factors; D014336:Troponin / Q000097:blood; D019210:Troponin I / Q000097:blood
D015415:Biomarkers; D007527:Isoenzymes; D009211:Myoglobin; D014336:Troponin; D019210:Troponin I; D003402:Creatine Kinase