In vitro and in vivo antibacterial activities of AM-1155 in the fields of obstetrics and gynecology.
AM-1155 is a new 8-methoxyquinolonecarboxylic acid with a broad spectrum of antibacterial activity. It inhibited more than 90% of clinical isolates of Streptococcus agalactiae, Escherichia coli, Peptostreptococcus magnus, Bacteroides fragilis and Prevotella bivia at the concentration of 3.13 mg/l. The antibacterial activity of AM-1155 was almost equal to that of sparfloxacin. The in vivo efficacy of AM-1155 was evaluated using a polymicrobial pyometra (E. coli and B. fragilis) model of rats. The accumulation of neutrophils to the uterus in the AM-1155-treated group was less marked than that of the nontreated group, as well as the bacteriological response. These results suggest that the new antimicrobial agent AM-1155 might be useful for the treatment of polymicrobial infections in the fields of obstetrics and gynecology.
Department of Obstetrics and Gynecology, School of Medicine, Gifu University, Japan.
H
H
Mikamo
K
K
Kawazoe
Y
Y
Sato
Y
Y
Hayasaki
K
K
Izumi
T
T
Tamaya
D000818:Animals; D000890:Anti-Infective Agents; D001441:Bacteroides fragilis / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects*; D005260:Female; D024841:Fluoroquinolones; D000077734:Gatifloxacin; D008826:Microbial Sensitivity Tests; D010879:Piperazines / Q000494:pharmacology* / Q000627:therapeutic use; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy* / Q000382:microbiology; D015363:Quinolones / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D014591:Uterine Diseases / Q000188:drug therapy* / Q000382:microbiology
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D010879:Piperazines; D015363:Quinolones; D000077734:Gatifloxacin