Immunoadsorption therapy in Guillain-Barré syndrome.
A 12-year-old boy rapidly developed Guillain-Barré syndrome (GBS) after Campylobacter jejuni enteritis. Electrophysiologic studies suggested that demyelination was dominant, and serum anti-C. jejuni and both IgG and IgM anti-GM1 antibodies were significantly elevated. The patient was treated three times with immunoadsorption therapy using a tryptophan-immobilized column. The volume of treated plasma in each session was about 2 L. His blood pressure was maintained within normal range with the use of 5% albumin preparations and etilefrine hydrochloride. His clinical and electrophysiologic findings began to recover shortly after therapy, with a decrease in the levels of serum IgG and IgM anti-GM1 antibodies. This immunoadsorption therapy should be considered for anti-GM1 antibody-associated GBS.
Division of Pediatrics, Social Insurance Kyoto Hospital, Japan.
K
K
Hirai
M
M
Kihara
F
F
Nakajima
Y
Y
Miyanomae
H
H
Yoshioka
D000907:Antibodies, Bacterial / Q000097:blood; D001323:Autoantibodies / Q000097:blood; D002169:Campylobacter Infections / Q000276:immunology / Q000628:therapy*; D016123:Campylobacter jejuni / Q000276:immunology; D002648:Child; D005677:G(M1) Ganglioside / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007163:Immunosorbent Techniques; D008297:Male; D011129:Polyradiculoneuropathy / Q000276:immunology / Q000628:therapy*
D000907:Antibodies, Bacterial; D001323:Autoantibodies; D007074:Immunoglobulin G; D005677:G(M1) Ganglioside