alpha-Melanocyte-stimulating hormone and acute renal failure.
alpha-Melanocyte-stimulating hormone (MSH) is an endogenous anti-inflammatory cytokine that inhibits all major forms of inflammation, alpha-MSH level is increased at sites of inflammation in humans, and is produced in the pituitary and in macrophages. The effects of alpha-MSH are mediated by melanocortin receptors found on macrophages, neutrophils, and renal tubules. alpha-MSH inhibited ischemic acute renal failure in mice and rats, even when started 6 h after injury. alpha-MSH acts, in part, by inhibiting the maladaptive activation of genes that cause inflammatory and cytotoxic renal injury. However, alpha-MSH is effective even in the absence of neutrophils, suggesting that alpha-MSH also acts directly on renal tubules.
Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, USA.
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Kohda
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Chiao
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D058186:Acute Kidney Injury / Q000188:drug therapy / Q000503:physiopathology*; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D007511:Ischemia / Q000188:drug therapy / Q000503:physiopathology*; D007684:Kidney Tubules / Q000187:drug effects / Q000503:physiopathology; D000521:alpha-MSH / Q000502:physiology* / Q000627:therapeutic use
D000521:alpha-MSH