Serotonin syndrome induced by transitioning from phenelzine to venlafaxine: four patient reports.
With the use of the newer antidepressants beyond the traditional tricyclics and monoamine oxidase inhibitors, newer options in headache prophylaxis are provided as well as the potential for undesirable and even potentially life-threatening interactions between medications. In this article, four patient reports of a specific interaction--the serotonin syndrome--are presented. These events resulted from transitioning headache patients from an older antidepressant (phenelzine) to a newer antidepressant (venlafaxine).
Diamond
S
S
Diamond Headache Clinic, Chicago, IL 60614-1726, USA.
Pepper
B J
BJ
Diamond
M L
ML
Freitag
F G
FG
Urban
G J
GJ
Erdemoglu
A K
AK
D000328:Adult; D002493:Central Nervous System Diseases / Q000139:chemically induced*; D003511:Cyclohexanols / Q000009:adverse effects*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy*; D008996:Monoamine Oxidase Inhibitors / Q000009:adverse effects*; D010624:Phenelzine / Q000009:adverse effects*; D012701:Serotonin / Q000378:metabolism*; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*; D000069470:Venlafaxine Hydrochloride
D003511:Cyclohexanols; D008996:Monoamine Oxidase Inhibitors; D010624:Phenelzine; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors; D000069470:Venlafaxine Hydrochloride