Synthesis of 1-(beta-D-glycopyranosyl)-3-deazapyrimidines from 2-hydroxy and 2-mercaptopyridines.
The synthesis of new 4- and 5-substituted-3-cyanopyridine nucleosides has been performed by reacting the silylated pyridines and penta-omicron-acetyl-alpha -D-glycopyranose in dichloroethane in the presence of SnCl4. The free nucleosides were tested for their potential activity against HIV and different types of tumor.
Attia
A M
AM
Chemistry Department, Faculty of Science, Qatar University, Doha, Egypt.
Elgemeie
G H
GH
Alnaimi
I S
IS
D011725:Pyridines / Q000737:chemistry*; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry*
D011725:Pyridines; D011743:Pyrimidines; C014047:hydroxypyridines; C029347:2-thiopyridine