New technologies for high-throughput screening.
To screen efficiently the millions of compounds that are synthesized using combinatorial and automated methods, dramatically improved assay technologies are currently needed. In 96-well microtiter plates, nonradioactive techniques (primarily fluorimetric) and cell-based functional methods have moved to the cutting edge, while clever assays that extract information from large bead-based combinatorial libraries have begun to show considerable promise. In the future, miniaturized assays that break out of the 96-well format will be enabled by innovative technologies for high-throughput screening.
Pharmacopeia, Inc., 101 College Road East, Princeton Forrestal Center, Princeton, NJ 08540, USA. burbaum@pharmacop.com
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D002625:Chemistry, Organic / Q000379:methods*; D008904:Miniaturization; D013050:Spectrometry, Fluorescence / Q000379:methods*