Anterior uveitis associated with latanoprost.
OBJECTIVE
To report the association of anterior uveitis with the use of latanoprost.


METHODS
We studied four patients with complicated open-angle glaucoma who had anterior uveitis associated with the use of latanoprost. The uveitis was unilateral and occurred only in the eye receiving latanoprost in three patients. In one patient, latanoprost was used in both eyes, and the uveitis was bilateral. Four of five eyes had a history of prior inflammation and/or prior incisional surgery. All patients were rechallenged with the drug.


RESULTS
The uveitis improved after cessation of latanoprost with or without topical corticosteroids. It recurred after rechallenging with latanoprost in all eyes.


CONCLUSIONS
There is a possible association between latanoprost and anterior uveitis. Topical prostaglandin analogs may be relatively contraindicated in patients with a history of uveitis or prior ocular surgery. This association may also be possible in eyes that have not had previous uveitis or incisional surgery.
Department of Ophthalmology, University of Medicine and Dentistry of New Jersey, Newark 07103, USA. fechtner@umdnj.edu
R D
RD
Fechtner
A S
AS
Khouri
T J
TJ
Zimmerman
J
J
Bullock
R
R
Feldman
P
P
Kulkarni
A J
AJ
Michael
T
T
Realini
R
R
Warwar
D000287:Administration, Topical; D000328:Adult; D000368:Aged; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D000077338:Latanoprost; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D011239:Prednisolone / Q000031:analogs & derivatives / Q000627:therapeutic use; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage / Q000009:adverse effects*; D014606:Uveitis, Anterior / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D014792:Visual Acuity
D005938:Glucocorticoids; D009883:Ophthalmic Solutions; D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost; C009935:prednisolone acetate; D011239:Prednisolone