Value of blood pool contrast agents in magnetic resonance angiography of the pelvis and lower extremities.
Our objective was: (1) to determine the appropriate dose of new ultrasmall superparamagnetic iron oxide particles for magnetic resonance angiography (MRA). This agent comprised of a single iron oxide crystal stabilized with a carbohydrate-polyethylene glycol coat (PEG-Ferron/NC 100150 injection); (2) to determine the proper flip angle for PEG-Ferron-enhanced 3 D time-of-flight (TOF) MRA sequence; and (3) to compare the enhancement of peripheral vessels following PEG-Ferron and GdDTPA-BMA. MRA parameters were: TR/TE = 50/2.1 ms, NEX = 1, FOV = 30 x 30 x 1.8 cm, and matrix = 256 x 128 x 64. In anesthetized beagle dogs (n = 10), the effects of PEG-Ferron and GdDTPA-BMA on regional signal were monitored for 45 min and compared. The lowest dose of PEG-Ferron (0.05 mmol/kg) produced the best enhancement of primary, secondary and tertiary vessels. The flip angle 60 degrees provided better enhancement than 20 degrees on contrast enhanced images. Unlike GdDTPA-BMA, PEG-Ferron allowed prolonged delineation (> 45 min) of the pelvis and lower extremities circulation. PEG-Ferron provided greater Contrast-to-noise ratio CNR (80.2 +/- 6.2, P < 0.05) than GdDTPA-BMA (63.5 +/- 2.5). It may be possible for blood pool contrast-enhanced 3 D TOF MRA to provide valuable information for visualization of vascular tree including guiding interventions.
Department of Radiology, University of California, San Francisco, CA 94143, USA.
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Saeed
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Wendland
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Engelbrecht
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Sakuma
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Higgins
D000818:Animals; D001808:Blood Vessels / Q000033:anatomy & histology; D003287:Contrast Media / Q000008:administration & dosage; D004285:Dogs; D019786:Gadolinium DTPA; D006614:Hindlimb / Q000098:blood supply*; D006912:Hydroxyquinolines / Q000008:administration & dosage; D007091:Image Processing, Computer-Assisted; D018810:Magnetic Resonance Angiography; D010388:Pelvis / Q000098:blood supply*; D011092:Polyethylene Glycols / Q000008:administration & dosage
D003287:Contrast Media; D006912:Hydroxyquinolines; D011092:Polyethylene Glycols; C002833:8-hydroxy-7-iodo-5-quinolinesulfonic acid; C064925:gadodiamide; D019786:Gadolinium DTPA