Science and pragmatism in the treatment and prevention of neutropenic infection.
The following aspects of the management of patients with granulocytopenia and fever are reviewed in this article: adaptation of initial antibiotic regimens to the recent changes in the most common causative pathogens (namely a change from Gram-negative bacteria to Gram-positive bacteria and fungi); subsequent modifications of the empirically administered treatments; improvement of the host's defence by reducing the duration of neutropenia; and indications for out patient therapy of febrile episodes.
Service de Médecine Interne et Laboratoire d'Investigation Clinique H. Tagnon, Institut Jules Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles, Brussels, Belgium.
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Klastersky
D000900:Anti-Bacterial Agents; D019072:Antibiotic Prophylaxis; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D005334:Fever / Q000276:immunology*; D016905:Gram-Negative Bacterial Infections / Q000276:immunology / Q000517:prevention & control*; D006801:Humans; D009181:Mycoses / Q000276:immunology / Q000517:prevention & control*; D009503:Neutropenia / Q000276:immunology*; D009894:Opportunistic Infections / Q000276:immunology / Q000517:prevention & control*
D000900:Anti-Bacterial Agents