Role of endothelin-1 in diabetes mellitus.
Endothelin-1 is mainly synthesized by the vascular endothelial cells and acts on the vascular smooth muscle. Because of its vasoconstrictor and mitogenic effects it plays a role in the development of vascular diseases. In diabetes mellitus atherosclerosis is accelerated. The authors summarize the available data of the role of endothelin-1 in Type 1 and Type 2 diabetes mellitus and the development of diabetic complication.
Sármán
B
B
Semmelweis Medical University 2nd and 1st Internal Medicine Department, Budapest, Hungary.
Tóth
M
M
Somogyi
A
A
D000818:Animals; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000503:physiopathology; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000503:physiopathology; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000209:etiology / Q000503:physiopathology; D019332:Endothelin-1 / Q000502:physiology*; D006801:Humans; D051381:Rats
D019332:Endothelin-1