Microparticle resins as a potential nasal drug delivery system for insulin.
The application of various resins for the nasal delivery of insulin was examined in rabbits. Intranasal administration of human insulin (28 U, 1 mg) mixed with fractionated sodium polystyrene sulfonate powder (an anionic resin with a particle size of 20-45 microns) caused a rapid increase of the plasma insulin level 413.0 +/- 71.7 microU/ml (mean +/- S.D.) after 15 min, while intranasal administration of insulin alone caused little increase. The blood glucose level decreased from 118.8 +/- 18.5 mg/dl to 65.8 +/- 13.8 mg/dl at 45 min after administration. These results were superior to those obtained with the unfractionated resin. Styrene-divinylbenzene copolymer (a nonionic resin; 20-45 microns fraction) showed similar enhancement of nasal insulin absorption. In contrast, polyacrylester (a nonionic resin; 20-45 microns fraction) and cholestyramine (a cationic resin) did not promote insulin absorption. These results suggest that some resins may be useful for nasal delivery of insulin.
Division of Drug Delivery Systems, St. Marianna University School of Medicine, Kawasaki, Japan.
M
M
Takenaga
Y
Y
Serizawa
Y
Y
Azechi
A
A
Ochiai
Y
Y
Kosaka
R
R
Igarashi
Y
Y
Mizushima
D000281:Administration, Intranasal; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D016503:Drug Delivery Systems; D006801:Humans; D007328:Insulin / Q000008:administration & dosage*; D008297:Male; D011817:Rabbits; D012116:Resins, Plant / Q000008:administration & dosage*
D001786:Blood Glucose; D007328:Insulin; D012116:Resins, Plant