[The importance of the canine model in medical genetics].
Dog domestication dates back to as early as 100,000 years ago, or 10,000 years depending upon the data used, and nowadays more than 350 breeds are duly registered in the different kennel clubs around the world. Due to intensive selection in the course of breeding, dog presently comes in any shape, size, color one can imagine, in addition to displaying a wide panel of characters, capacities and behaviours. As a consequence of excessive breeding, numerous breeds are plagued by a large variety of genetic diseases, many of them resembling those observed in human. All this makes dog an attractive model to track down genes and alleles responsible for those phenotypic behavioural or pathological traits, provided a genome map with polymorphic markers, and genes is available.
UPR 41 CNRS, Faculté de Médecine, Rennes.
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Galibert
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André
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Chéron
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JC
Chuat
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Hitte
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Jiang
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Jouquand
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Priat
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Rénier
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Vignaux
D000818:Animals; D002874:Chromosome Mapping; D004285:Dogs; D005826:Genetics, Medical; D006801:Humans; D008957:Models, Genetic; D011110:Polymorphism, Genetic