[Adverse reactions and immune response to Heberbiovac-HB vaccine administered to infants simultaneously with DPT and VA-MENGOC-BC].
The Cuban recombinant yeast-derived hepatitis B vaccine (Heberbiovac-HB) was administered to 2 groups of infants aged 3 months. A dosage of 10 micrograms was used through a scheme of 0, 1 and 6 and 0, 1, 2 and 12, coinciding with the DPT and anti-meningococcal vaccines, according to the immunization schedule. Reactogenicity and immunogenicity were studied in both groups. The reactions observed were mild and similar to other studies, where fever , erythema and induration were the most common signs. These 2 groups had high percentages of children with titres of antibodies anti HBs above 100 UI/L-1. It is demonstrated the acceptable reactogenicity of the vaccine and the non-immunological interference of other vaccines.
Instituto de Medicina Tropical Pedro Kourí, Ciudad de La Habana, Cuba.
M
M
Díaz González
L
L
Rodríguez Lay
A U
AU
López-Chávez
J R
JR
Bravo González
P
P
Pedroso Flaquet
D000907:Antibodies, Bacterial / Q000096:biosynthesis; D001428:Bacterial Vaccines / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D001886:Bordetella pertussis / Q000276:immunology; D003017:Clostridium tetani / Q000276:immunology; D003353:Corynebacterium diphtheriae / Q000276:immunology; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D004890:Erythema / Q000209:etiology; D005334:Fever / Q000209:etiology; D006510:Hepatitis B Antibodies / Q000096:biosynthesis; D017325:Hepatitis B Vaccines / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D006801:Humans; D007115:Immunization Schedule; D007223:Infant; D007258:Informed Consent; D022401:Meningococcal Vaccines; D009345:Neisseria meningitidis / Q000276:immunology; D014614:Vaccines, Synthetic / Q000008:administration & dosage* / Q000276:immunology
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines; D022401:Meningococcal Vaccines; D014614:Vaccines, Synthetic