Immobilization strategies for biological scanning probe microscopy.
Biological atomic force microscopy (AFM) is now established as a method for studying the structure and function of biomolecular objects at the solid-liquid interface. Major progress in this field is linked to new developments in instrumentation, a better understanding of tip-sample interactions, and improved sample preparation techniques. In this review, the most common strategies for biomolecular immobilization with respect to biological AFM applications are summarized.
Wagner
P
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Department of Biochemistry, Stanford University Medical Center, CA 94305-5307, USA. pwagner@stanford.edu
D018625:Microscopy, Atomic Force / Q000379:methods*