Histology may depend on the presence of partial monosomy or partial trisomy 3 in renal cell carcinoma.
Rearrangements of 3q were found in 10% of a series of 230 cases of renal cell carcinoma (RCC). Together with observations from the literature, these structural changes can be concluded to involve two different regions, 3q21 and 3q11-12, and are usually present as unbalanced translocations. In some of these cases of RCC with the translocation, the normal chromosome 3 may reduplicate, giving rise to a partial trisomy 3q instead of a partial monosomy 3. In those cases, however, histology shows chromophilic-papillary RCC instead of clear cell-nonpapillary. Hence, besides the still unresolved underlying molecular changes causing RCC, histology may in part depend on the presence of partial monosomy or partial trisomy 3.
Cattedra di Anatomia e Istologia Patologica dell' Università-Spedali Civili di Brescia, Italy.
P
P
Balzarini
P
P
Dal Cin
T
T
Roskams
P
P
Polito
H
H
Van Poppel
B
B
Van Damme
L
L
Baert
H
H
Van den Berghe
D000231:Adenocarcinoma, Papillary / Q000175:diagnosis / Q000235:genetics*; D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000175:diagnosis / Q000235:genetics*; D002872:Chromosome Deletion; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009006:Monosomy / Q000473:pathology*; D014314:Trisomy / Q000473:pathology*