The role of H2-receptor antagonists in the pathogenesis of nosocomial pneumonia in mechanically ventilated patients.
We conducted a computerized MEDLINE search and selected controlled studies and meta-analyses correlating the frequency of nosocomial pneumonia (NP) with the administration of histamine2-receptor antagonists (H2RAs) as stress ulcer prophylaxis in critically ill patients. Although such a correlation does exist, the literature supports the theory that gastric bacterial overcolonization through alkalinization by H2RAs is not a risk factor for NP in critically ill patients. Further well-designed studies are necessary to resolve the issue and clarify the role of H2RAs in the pathogenesis of NP.
Trofe
J
J
Department of Pharmacy Practice and Pharmacy Administration, Philadelphia College of Pharmacy and Science, Pennsylvania 19104, USA.
Peterson
A M
AM
D003428:Cross Infection / Q000209:etiology*; D006635:Histamine H2 Antagonists / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D015201:Meta-Analysis as Topic; D011014:Pneumonia / Q000209:etiology*; D012121:Respiration, Artificial / Q000009:adverse effects*
D006635:Histamine H2 Antagonists