Immunophenotypic and clinical features of T-cell receptor gammadelta+ T-lineage acute lymphoblastic leukaemia.
The immunophenotypic and clinical features of TCR-gammadelta+ T-lineage acute lymphoblastic leukaemia (T-ALL) were prospectively analysed in 52 children with membrane CD3+ T-ALL. We observed a relatively high incidence of TCR-gammadelta+ T-ALL (26/52 patients). Leukaemic blasts from 22 children demonstrated TCR-alphabeta positivity, and simultaneous expression of the TCR-beta and -delta chain was found in four children. Clinical and haematological features of TCR-alphabeta and gammadelta+ T-ALL did not differ significantly, except that haemoglobin levels were significantly lower in TCR-gammadelta+ cases. Event-free survival at 4 years was significantly better in TCR-gammadelta+ compared with TCR-alphabeta+ T-ALL, but expression of TCR molecules did not emerge as an independent prognostic factor in multivariate analysis.
Department of Haematology, Oncology, and Tumour Immunology, Robert-Rössle-Clinic, Charité, Humboldt-University of Berlin, Germany.
G
G
Schott
C
C
Sperling
M
M
Schrappe
R
R
Ratei
M
M
Martin
U
U
Meyer
H
H
Riehm
W D
WD
Ludwig
D000208:Acute Disease; D015703:Antigens, CD / Q000276:immunology; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D018572:Disease-Free Survival; D006801:Humans; D016130:Immunophenotyping; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000276:immunology*; D011241:Prednisone / Q000627:therapeutic use; D011379:Prognosis; D011446:Prospective Studies; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology*
D015703:Antigens, CD; D018931:Antineoplastic Agents, Hormonal; D016693:Receptors, Antigen, T-Cell, alpha-beta; D011241:Prednisone