Evaluation of a rough mutant of Brucella melitensis in pregnant goats.
Brucella melitensis strain VTRM1, a rough derivative of B melitensis strain 16M, is able to colonise the lymph nodes of goats, does not induce abortion in pregnant goats when used at doses leading to abortions with virulent strain 16M, and does not induce anti-O chain antibodies. However, strain VTRM1 as a single dose vaccine induces only partial protection against both infection and abortion following challenge.
Elzer
P H
PH
Department of Veterinary Science, Louisiana State University Agricultural Center, Baton Rouge 70803, USA. Pelzer@unix1.sncc.lsu.edu
Enright
F M
FM
McQuiston
J R
JR
Boyle
S M
SM
Schurig
G G
GG
D000034:Abortion, Veterinary / Q000382:microbiology*; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D017347:Brucella melitensis / Q000235:genetics / Q000472:pathogenicity; D002006:Brucellosis / Q000276:immunology / Q000503:physiopathology / Q000662:veterinary*; D005260:Female; D015511:Goat Diseases / Q000276:immunology / Q000382:microbiology* / Q000503:physiopathology; D006041:Goats; D011247:Pregnancy; D013045:Species Specificity
D000907:Antibodies, Bacterial