Soluble ICAM-1, demyelination, and inflammation in multiple sclerosis and acute optic neuritis.
We measured sICAM-1 in paired samples of serum and cerebrospinal fluid (CSF) from patients with an attack of multiple sclerosis (MS) (n = 50) and patients with acute monosymptomatic optic neuritis (ON) as a possible first attack of MS were also included (n = 25). Based on calculations of extended indices we found evidence of intrathecal synthesis of sICAM-1 both in patients with clinically definite MS and in patients with idiopathic ON compared to neurological control subjects. The amount of intrathecally synthesized sICAM-1 correlated significantly to the CSF leukocyte count and to the concentration of myelin basic protein in the CSF. The serum concentrations of sICAM-1 were not increased in patients with demyelinating disease compared to the neurological control subjects.
Institute for Inflammation Research, IIR-RHIMA 7544, The National University Hospital, Rigshospitalet, Copenhagen, Denmark.
A A
AA
Petersen
F
F
Sellebjerg
J
J
Frederiksen
J
J
Olesen
G L
GL
Vejlsgaard
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007249:Inflammation / Q000473:pathology; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000378:metabolism* / Q000473:pathology*; D004676:Myelin Basic Protein / Q000134:cerebrospinal fluid; D009186:Myelin Sheath / Q000378:metabolism*; D009902:Optic Neuritis / Q000378:metabolism* / Q000473:pathology*; D009994:Osmolar Concentration; D012044:Regression Analysis; D012709:Serum Albumin / Q000134:cerebrospinal fluid; D012995:Solubility; D013116:Spinal Cord / Q000378:metabolism
D004676:Myelin Basic Protein; D012709:Serum Albumin; D018799:Intercellular Adhesion Molecule-1