Effect of alpha-tocopherol supplementation on the impact of aflatoxin B1 on the testes of rats.
Rats were given aflatoxin B1 (7.5 microg/200 g b.w.) and alpha-tocopherol (0.9 mg/200 g b.w.) for 14 days oral intubation to investigate the effect of alpha-tocopherol on the toxicity of aflatoxin B1 on rat's testes. There were significant alterations in testicular sorbitol dehydrogenase, lactic dehydrogenase, glucose-6-phosphate dehydrogenase, gamma glutamyl transpeptidase; reduced quality of sperm and marked pathological changes in the testis of rats given aflatoxin B1 alone. Alpha-tocopherol supplementation increased the aflatoxin blood level. A reduction in the toxicity of free radicals by alpha-tocopherol in association with a reduction in aflatoxin metabolism seem to be responsible for the protective influence observed.
Embryotoxicology section industrial toxicology research centre (ITRC), Lucknow, India.
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IN
Ibeh
D K
DK
Saxena
D016604:Aflatoxin B1 / Q000494:pharmacology / Q000633:toxicity*; D000818:Animals; D019587:Dietary Supplements; D004347:Drug Interactions; D005609:Free Radicals / Q000633:toxicity; D008297:Male; D051381:Rats; D013723:Teratogens / Q000494:pharmacology / Q000633:toxicity*; D013737:Testis / Q000187:drug effects* / Q000201:enzymology; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology*
D005609:Free Radicals; D013723:Teratogens; D014810:Vitamin E; D016604:Aflatoxin B1