Design, synthesis, and evaluation of potential GAR and AICAR transformylase inhibitors.
Boger
D L
DL
Department of Chemistry, Scripps Research Institute, La Jolla, California 92037, USA.
Kochanny
M J
MJ
Cai
H
H
Wyatt
D
D
Kitos
P A
PA
Warren
M S
MS
Ramcharan
J
J
Gooljarsingh
L T
LT
Benkovic
S J
SJ
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D019877:Hydroxymethyl and Formyl Transferases / Q000037:antagonists & inhibitors*; D051379:Mice; D051027:Phosphoribosylaminoimidazolecarboxamide Formyltransferase; D051026:Phosphoribosylglycinamide Formyltransferase; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D011743:Pyrimidines; D011799:Quinazolines; D019877:Hydroxymethyl and Formyl Transferases; D051026:Phosphoribosylglycinamide Formyltransferase; D051027:Phosphoribosylaminoimidazolecarboxamide Formyltransferase