Renal function abnormalities and incident cataract after a five-year interval: The Beaver Dam Eye Study.
OBJECTIVE
To evaluate the relationship between renal function abnormalities and incidence of age-related cataract.


METHODS
In a population-based epidemiologic study of age-related eye disease, cataract was classified based on lens photographs. Standard methods of grading were used. Blood urea nitrogen, serum creatinine, and gross proteinuria were measured using standard protocols.


RESULTS
Cortical cataract was associated with increased BUN, but after controlling for age, this relationship was no longer significant. In those with diabetes, elevated BUN or elevated creatinine was associated with increased odds of posterior subcapsular cataract, but these relationships were not significant.


CONCLUSIONS
Renal function abnormalities were not significantly associated with incidence of cataract after controlling for age and gender. However, the power to test these associations was limited. Further longitudinal follow-up of this cohort as well as other studies designed to evaluate these associations are needed.
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison 53705-2397, USA.
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D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001806:Blood Urea Nitrogen; D002386:Cataract / Q000150:complications* / Q000453:epidemiology*; D003404:Creatinine / Q000097:blood; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000097:blood; D006801:Humans; D015994:Incidence; D007668:Kidney / Q000503:physiopathology*; D007674:Kidney Diseases / Q000150:complications* / Q000503:physiopathology; D007677:Kidney Function Tests; D008875:Middle Aged; D013997:Time Factors
D003404:Creatinine