Metal-ion regulation of gene expression in yeast.
Metal-responsive transcription factors exist in yeast to modulate expression of genes that encode proteins involved in cellular uptake of copper, iron and zinc ions. These signal transduction pathways function in the cellular regulation of the intracellular concentration of free metal ions. A second component of metal homeostasis is the regulation of metal-ion binding through protein-mediated metallation. Copper-specific chaperones exist in yeast that route copper ions to the site of biosynthesis of copper-metalloenzymes.
University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA. dennis.winge@hsc.utah.edu
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Winge
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Jensen
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Srinivasan
D003300:Copper / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000737:chemistry; D015966:Gene Expression Regulation, Fungal / Q000235:genetics*; D007501:Iron / Q000378:metabolism; D008667:Metalloproteins / Q000378:metabolism; D008670:Metals / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics; D015032:Zinc / Q000378:metabolism
D004268:DNA-Binding Proteins; D008667:Metalloproteins; D008670:Metals; D014157:Transcription Factors; D003300:Copper; D007501:Iron; D015032:Zinc