[The effect of isotheoline on mouse behavior under test conditions for detecting its anxiolytic activity].
The effect of isotheolin, a glaucin derivative, on the behavior of mice was studied under conditions of a model of preference of the dark section of the chamber to the light one which is used for appraisal of the anxiolytic/anxiogenic activity of substances. Intraperitoneal injection of isotheolin in a dose range of 0.25-4 mg/kg antagonized the anxiogenic effect induced by the serotonin agonist [correction of antagonist] chlorophenylpiperazine, mCPP (4 mg/kg). In a dose of 4 mg/kg isotheolin has an anxiolytic effect on intact animals. Bearing in mind that mCPP produces its anxiogenic effect via the 5-HT2C receptors, it is suggested that the mechanism of the anxiolytic action of isotheolin is realized through its interaction with the serotoninergic system at the level of 5-HT2C receptors.
Zheliazkova-Savova
M
M
Chair of Pharmacology, Varna Medical Medical University, Bulgaria.
D000704:Analysis of Variance; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001007:Anxiety / Q000139:chemically induced / Q000517:prevention & control; D001060:Aporphines / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D003624:Darkness; D004305:Dose-Response Relationship, Drug; D008027:Light; D008297:Male; D051379:Mice; D010879:Piperazines / Q000037:antagonists & inhibitors; D011985:Receptors, Serotonin / Q000187:drug effects; D012702:Serotonin Antagonists / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D001060:Aporphines; D010879:Piperazines; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; C044170:isoteolin; C015068:1-(3-chlorophenyl)piperazine