Distribution of free D-amino acids in tissues and body fluids of vertebrates.
Reports on the distribution, metabolism and origins of free D-amino acids in vertebrate tissues and body fluids are reviewed. The transient emergence of D-aspartic acid during the development of brain and peripheral organs or early stages of life is reported. D-Serine in brain is postulated to be a potentiator for the N-methyl-D-aspartate (NMDA) receptor. Some D-amino acid concentrations in human serum, such as D-Ser and D-Ala, are suggested to correlate with damage to renal function.
Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
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Imai
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Fukushima
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Santa
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Homma
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Huang
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Sakai
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Kato
D000409:Alanine / Q000378:metabolism*; D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism*; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D012694:Serine / Q000378:metabolism*; D013237:Stereoisomerism; D014714:Vertebrates / Q000378:metabolism*
D016194:Receptors, N-Methyl-D-Aspartate; D001224:Aspartic Acid; D012694:Serine; D000409:Alanine