Generation of tumor-specific cytotoxic T lymphocytes and memory T cells by immunization with tumor-derived heat shock protein gp96.
Tumor-derived heat shock proteins have been shown previously to elicit specific prophylactic immunity to cognate tumors. Here we establish that administration of gp96 results in generation of tumor-specific cytotoxic T lymphocyte response in addition to protective immunity. In one instance, gp96 preparations are shown to elicit an immune response against a tumor, where intact tumor cells are unable to do so. Finally, our results indicate that gp96 preparations elicit a memory T cell response that is capable of being recalled.
Janetzki
S
S
Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington 06030-1601, USA.
Blachere
N E
NE
Srivastava
P K
PK
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D005260:Female; D007156:Immunologic Memory; D051379:Mice; D008809:Mice, Inbred C3H; D013601:T-Lymphocytes / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014611:Vaccination
D000951:Antigens, Neoplasm; C052646:sarcoma glycoprotein gp96 rejection antigens