Chemoattractant factors and the control of human immunodeficiency virus replication.
Factors secreted by CD8(+) T cells have been described to suppress immunodeficiency virus replication. The research efforts to identify these factors led to the proposal of some candidate proteins as being responsible for the antiviral effects. Chemokines and IL-16 are secreted by CD8(+) T cells and inhibit HIV replication through different mechanisms. However, their antiviral properties cannot fully explain the inhibitory activities found in cell culture supernatants from CD8(+) T cells.
Baier
M
M
Paul Ehrlich Institute, Langen, Germany. m.baier@em.uni-frankfurt.de
Bannert
N
N
Werner
A
A
Adler
H S
HS
Otteken
A
A
Beer
B
B
Norley
S
S
Kurth
R
R
D000998:Antiviral Agents / Q000276:immunology / Q000378:metabolism / Q000627:therapeutic use; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000821:virology; D002478:Cells, Cultured; D018925:Chemokines / Q000276:immunology / Q000378:metabolism / Q000627:therapeutic use; D006678:HIV / Q000276:immunology*; D006801:Humans; D019410:Interleukin-16 / Q000276:immunology / Q000378:metabolism / Q000627:therapeutic use; D014779:Virus Replication / Q000276:immunology*
D000998:Antiviral Agents; D018925:Chemokines; D019410:Interleukin-16