A model of hippocampal memory encoding and retrieval: GABAergic control of synaptic plasticity.
The current view of the role of GABAergic interneurones in cortical-network function has shifted from one of merely dampening neuronal activity to that of an active role in information processing. In this review, we explore a potential role of hippocampal GABAergic interneurones in providing spatial and temporal conditions for modifications of synaptic weights during hippocampus-dependent memory processes. We argue that knowledge of spatiotemporal activity patterns in distinct classes of interneurone is essential to understanding the cellular mechanisms underlying learning and memory.
Paulsen
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O
MRC Anatomical Neuropharmacology Unit, University Dept of Pharmacology, Oxford, UK.
Moser
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EI
D004569:Electroencephalography; D006624:Hippocampus / Q000502:physiology* / Q000648:ultrastructure; D006801:Humans; D008568:Memory / Q000502:physiology*; D008606:Mental Processes / Q000145:classification / Q000502:physiology; D008959:Models, Neurological; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000145:classification / Q000648:ultrastructure; D018079:Receptors, GABA / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000096:biosynthesis*
D018079:Receptors, GABA; D005680:gamma-Aminobutyric Acid