Translocation (3;5)(p26;q13) in a patient with chronic T-cell lymphoproliferative disorder.
A 67-year-old patient with large granular lymphocyte (LGL) leukemia is described. At fluorescence-activated cell sorting (FACS) analysis of the peripheral blood, the lymphocytes were positive for CD3, CD4, CD5, CD29, CD45RA, CD57, and TCR alpha/beta and negative for CD7, CD8, CD16, CD56, CD19, CD22, and TCR gamma/delta. Bone marrow histology and immunohistochemistry did not reveal any lymphocyte infiltration. Cytogenetic examination of peripheral blood cultures showed a clone with the karyotype 46,XY,t(3;5)(p26;q13). Molecular analysis revealed rearrangement of the gamma-T-cell-receptor chain. The region 3p25-3p26 which harbors the von Hippel-Lindau tumor suppressor gene and the RAF1 oncogene has been rearranged in a few cases of T-cell leukemia. The translocation in this case has not yet been described and may reflect an alternative mechanism in the pathogenesis of these disorders.
Department of Internal Medicine, University of Graz, Austria.
H H
HH
Schmidt
H
H
Pirc-Danoewinata
E R
ER
Panzer-Grümayer
H
H
Sill
P
P
Sedlmayr
P
P
Neumeister
W
W
Linkesch
O A
OA
Haas
D000368:Aged; D015703:Antigens, CD / Q000276:immunology; D002893:Chromosomes, Human, Pair 3; D002895:Chromosomes, Human, Pair 5; D006801:Humans; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000235:genetics* / Q000276:immunology; D008297:Male; D014178:Translocation, Genetic
D015703:Antigens, CD