What determines primary breast cancer patients' hope to recover.
The main purpose was to offer evidence for the hypothesis that the stronger an acute real life stressor, namely, hearing from the physician that one has breast cancer and that one has to undergo mastectomy, the greater the induced noradrenaline (NA) depletion in the central nervous system (CNS) and the more the patient loses hope to recover. The data were derived from answers to interviews, questionnaires, and analyses of blood samples obtained from the patients on the day of admission to the hospital for a biopsy and 24 hours after the surgeon communicated the results of the biopsy to the patients. Analysis showed that a decline in 3-Methoxy 4-Hydroxy Methoxy 4-Hydroxy Phenylethylene Glycol (MHPG) concentration in blood plasma samples after being informed of the diagnosis is associated with less hope of recovery. MHPG is the main metabolite of CNS noradrenaline.
University of Antwerp-RUCA, Belgium. bertdb@ruca.ua.ac.be
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B
De Brabander
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P
Gerits
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R
Sacré
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J
Lamote
D000223:Adaptation, Psychological / Q000502:physiology; D000328:Adult; D000368:Aged; D001143:Arousal / Q000502:physiology; D001943:Breast Neoplasms / Q000097:blood / Q000523:psychology*; D003863:Depression / Q000097:blood / Q000523:psychology; D005260:Female; D006801:Humans; D007389:Internal-External Control; D007406:Interview, Psychological; D008734:Methoxyhydroxyphenylglycol / Q000097:blood; D008875:Middle Aged; D009042:Motivation; D009638:Norepinephrine / Q000502:physiology; D011379:Prognosis; D012803:Sick Role
D008734:Methoxyhydroxyphenylglycol; D009638:Norepinephrine