The incorporation of lamotrigine into the routine automated sequential trace enrichment of dialysates assay of anticonvulsants.
We have extended automated sequential trace enrichment of dialysates and high performance liquid chromatography to include the simultaneous assay of lamotrigine with other anticonvulsant drugs: phenobarbitone, carbamazepine and phenytoin. The procedure is reliable and precise (between-batch coefficients of variation < 2.8%) with no interference from other commonly prescribed drugs. Patients on lamotrigine presented with serum concentrations up to 67 mumol/L with no adverse effects, suggesting that the therapeutic range may need re-appraisal.
Higgins
G
G
Department of Clinical Chemistry, Royal Liverpool University Hospital, UK.
Hughes
A
A
Dutton
J
J
Roberts
N B
NB
D000927:Anticonvulsants / Q000097:blood*; D002220:Carbamazepine / Q000031:analogs & derivatives / Q000097:blood; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D006801:Humans; D000077213:Lamotrigine; D010634:Phenobarbital / Q000097:blood; D010672:Phenytoin / Q000097:blood; D014227:Triazines / Q000097:blood*
D000927:Anticonvulsants; D014227:Triazines; D002220:Carbamazepine; D010672:Phenytoin; C012227:carbamazepine epoxide; D000077213:Lamotrigine; D010634:Phenobarbital