Multiple antimutagenesis mechanisms affect mutagenic activity and specificity of the base analog 6-N-hydroxylaminopurine in bacteria and yeast.
Base analog 6-N-hydroxylaminopurine is a potent mutagen in variety of prokaryotic and eukaryotic organisms. In the review, we discuss recent results of the studies of HAP mutagenic activity, genetic control and specificity in bacteria and yeast with the emphasis to the mechanisms protecting living cells from mutagenic and toxic effects of this base analog.
Kozmin
S G
SG
Department of Genetics, Sankt-Petersburg University, Sankt-Petersburg, 199034, Russian Federation.
Schaaper
R M
RM
Shcherbakova
P V
PV
Kulikov
V N
VN
Noskov
V N
VN
Guetsova
M L
ML
Alenin
V V
VV
Rogozin
I B
IB
Makarova
K S
KS
Pavlov
Y I
YI
D000225:Adenine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000595:Amino Acid Sequence; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001483:Base Sequence; D004269:DNA, Bacterial / Q000187:drug effects; D004271:DNA, Fungal / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics; D008969:Molecular Sequence Data; D009153:Mutagens / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000235:genetics; D017386:Sequence Homology, Amino Acid
D016587:Antimutagenic Agents; D004269:DNA, Bacterial; D004271:DNA, Fungal; D009153:Mutagens; C032610:6-N-hydroxylaminopurine; D000225:Adenine