Interstitial laser coagulation: evaluation of the effect of normal liver blood perfusion and the application mode on lesion size.
OBJECTIVE
The effect of temporarily interrupted hepatic blood flow and multiple-fiber application on necrosis volume in interstitial laser coagulation (ILC) was investigated.


METHODS
Single- and multiple-fiber ILC were performed in porcine livers with normal as well as interrupted perfusion. Temperatures were determined. Lesions were measured and studied by light microscopy 4 hours post-treatment.


RESULTS
ILC with multiple-fiber application led to significantly greater individual lesion volumes (3.7 +/- 0.5 cm3) than single-fiber application (2.5 +/- 0.5 cm3) (P < .01). The interruption of hepatic perfusion led to a significant increase in lesion volume with single- (7.5 +/- 1.0 cm3) as well as multiple-fiber application (12.6 +/- 2.2 cm3) (P < .01). Superposition of the lesions in the multiple-fiber application mode was only determined with interrupted perfusion (total volume: 50.3 +/- 6.6 cm3).


CONCLUSIONS
Interruption of hepatic perfusion increases lesion volumes significantly. ILC for treating liver tumors should preferably be performed by application routes that permit temporary interruption of hepatic perfusion.
Albrecht
D
D
Department of Surgery, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin, Germany.
Germer
C T
CT
Isbert
C
C
Ritz
J P
JP
Roggan
A
A
Müller
G
G
Buhr
H J
HJ
D000818:Animals; D066298:In Vitro Techniques; D017075:Laser Coagulation / Q000009:adverse effects / Q000379:methods*; D008099:Liver / Q000098:blood supply* / Q000473:pathology / Q000601:surgery*; D008114:Liver Neoplasms, Experimental / Q000601:surgery; D009336:Necrosis; D013552:Swine