Developments in technology and applications of microsystems.
In the past year, microchips as applied to miniaturised total analysis systems, or microTAS, have benefited from technological improvements in their fabrication and been applied to analysis in many different biological areas. From a technological perspective, salient work includes fast, cheap and easy micromachining in polymers and integrated optical detection. From the bioapplications perspective, advances in DNA and protein separations, cell manipulations, immunoassays and polymerase chain reaction using on-chip electrophoretic separation stand out.
Zeneca/SmithKline Beecham Centre for Analytical Science, Department of Chemistry, Imperial College, London, SW7 2AY, UK. m.kopp@ic.ac.uk
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Kopp
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Crabtree
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D002623:Chemistry Techniques, Analytical / Q000295:instrumentation* / Q000379:methods; D008904:Miniaturization; D012666:Semiconductors