[The effect of the new nootropic dipeptide GVS-111 in different functional disorders of the escape reaction].
The authors studied the effect of a new nootropic agent with anxiolytic properties GVS-111 (ethyl ether N-phenylacetyl-L-prolylglycine) on formation of the avoidance reaction (AR) in rats and its functional disorders which were induced by two methods. In one case the stereotype of the relations between the stimulus, reaction and its consequence which developed during the experiment were urgently disturbed: the change of the animal to the other half of the chamber in response to a conditioned stimulus did not lead to its cutting off and prevention of the electropain stimulation for three successive combinations (AR error). In another case the spatial stereotype of the experiment was altered by changing the place of the opening through which the animal avoided the stimulus (spatial remodeling). Intraperitoneal injection of GVS-111 (0.1 mg/kg/day) improved the learning, but the effect differed from experiment to experiment. Along with this, the dipeptide prevented AR disturbance during the error and quickened restoration of the habit in spatial remodeling. It was shown earlier that AR disorders during an error are prevented by anxiolytics and nootropic agents but during spatial remodeling only by nootropic agents. It may be assumed that the positive effect of GSV-111 on AR in functional disorders is due to its nootropic effect.
Lomonosov Moscow State University, Russia.
A N
AN
Inozemtsev
S S
SS
Trofimov
G G
GG
Borlikova
F A
FA
Firova
L L
LL
Pragina
T A
TA
Gudasheva
R U
RU
Ostrovskaia
N A
NA
Tushmalova
T A
TA
Voronina
D000161:Acoustic Stimulation; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D004151:Dipeptides / Q000494:pharmacology*; D004558:Electric Stimulation; D004924:Escape Reaction / Q000187:drug effects* / Q000502:physiology; D008297:Male; D018697:Nootropic Agents / Q000494:pharmacology*; D051381:Rats; D018709:Statistics, Nonparametric; D013997:Time Factors
D014151:Anti-Anxiety Agents; D004151:Dipeptides; D018697:Nootropic Agents; C103871:ethyl phenylacetyl-Pro-Gly