Imaging subcortical auditory activity in humans.
There is a lack of physiological data pertaining to how listening humans process auditory information. Functional magnetic resonance imaging (fMRI) has provided some data for the auditory cortex in awake humans, but there is still a paucity of comparable data for subcortical auditory areas where the early stages of processing take place, as amply demonstrated by single-unit studies in animals. It is unclear why fMRI has been unsuccessful in imaging auditory brain-stem activity, but one problem may be cardiac-related, pulsatile brain-stem motion. To examine this, a method eliminating such motion (using cardiac gating) was applied to map sound-related activity in the auditory cortices and inferior colliculi in the brain stem. Activation in both the colliculi and cortex became more discernible when gating was used. In contrast with the cortex, the improvement in the colliculi resulted from a reduction in signal variability, rather than from an increase in percent signal change. This reduction is consistent with the hypothesis that motion or pulsatile flow is a major factor in brain-stem imaging. The way now seems clear to studying activity throughout the human auditory pathway in listening humans.
Department of Radiology, Massachusetts General Hospital, Charlestown 02129, USA.
A R
AR
Guimaraes
J R
JR
Melcher
T M
TM
Talavage
J R
JR
Baker
P
P
Ledden
B R
BR
Rosen
N Y
NY
Kiang
B C
BC
Fullerton
R M
RM
Weisskoff
D001303:Auditory Cortex / Q000502:physiology; D001306:Auditory Pathways / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D001933:Brain Stem / Q000502:physiology*; D017352:Echo-Planar Imaging; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007245:Inferior Colliculi / Q000502:physiology; D008297:Male; D012016:Reference Values