Reversible azoospermia in a patient treated with triazolam.
This is a report of a 26-year-old schizophrenic man treated with triazolam, levomepromazine, trifluoperazine and biperiden, who showed complete absence of spermatozoa in seminal analysis with normal plasma hormone levels. Sperm count reached 151 x 10(6)/ml after 6 months of triazolam withdrawal. A reversible effect of triazolam is suggested at the level of the germinal cells which are differentiating, without affecting the stem cells.
Department of Urology, Hospital del Mar, Autonomous University of Barcelona, Spain.
O
O
Arango
O
O
Bielsa
S
S
Grau
A
A
Gelabert-Mas
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects; D001712:Biperiden / Q000009:adverse effects; D016903:Drug Monitoring; D004359:Drug Therapy, Combination; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects*; D008297:Male; D008728:Methotrimeprazine / Q000009:adverse effects; D009845:Oligospermia / Q000139:chemically induced*; D012559:Schizophrenia / Q000188:drug therapy; D013076:Sperm Count / Q000187:drug effects; D014229:Triazolam / Q000009:adverse effects*; D014268:Trifluoperazine / Q000009:adverse effects
D014150:Antipsychotic Agents; D006993:Hypnotics and Sedatives; D001712:Biperiden; D014229:Triazolam; D014268:Trifluoperazine; D008728:Methotrimeprazine