Severe expression of corpus gastritis is characteristic in gastric cancer patients infected with Helicobacter pylori.
In 50 Helicobacter pylori-infected gastric carcinoma patients the corpus gastritis was significantly higher than in matched H. pylori-positive control subjects (P < 0.01). Atrophy and intestinal metaplasia (IM) occurred significantly more often in the antrum of carcinoma patients (P < 0.01). The odds ratio for gastric carcinoma was 8.85 for high-grade corpus gastritis and 8.04 when atrophy in the antrum was present.
Medical Department I, Technical University Hospital, Dresden, Germany.
S
S
Miehlke
A
A
Hackelsberger
A
A
Meining
R
R
Hatz
N
N
Lehn
P
P
Malfertheiner
M
M
Stolte
E
E
Bayerdörffer
D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D005756:Gastritis / Q000209:etiology*; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000209:etiology* / Q000473:pathology