Estimation of age-specific reference ranges via smoother AVAS.
This paper proposes a new non-parametric procedure to estimate age-dependent reference ranges based on Tibshirani's AVAS (additivity and variance stabilization) procedure for non-parametric estimation of transformations for regression. Several examples are given to illustrate the flexibility and applicability of the proposed method; these include alkaline phosphatase in girls, and foot length and head circumference during gestation.
Tango
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Department of Epidemiology, Institute of Public Health, Tokyo, Japan. tango@iph.go.jp
D000293:Adolescent; D000367:Age Factors; D000469:Alkaline Phosphatase / Q000097:blood; D000704:Analysis of Variance; D002648:Child; D002675:Child, Preschool; D003196:Computer Graphics; D005260:Female; D005333:Fetus / Q000033:anatomy & histology; D005528:Foot / Q000033:anatomy & histology; D005865:Gestational Age; D006257:Head / Q000033:anatomy & histology; D006801:Humans; D007223:Infant; D012016:Reference Values; D012044:Regression Analysis
D000469:Alkaline Phosphatase