Transgenic assays for mutations and cancer: current status and future perspectives.
Transgenic mouse modelling has proved to be a powerful approach to explore the various steps involved in spontaneous and induced carcinogenesis. Some of the multitude of models currently available have the potential to become a substitute for the expensive, long-term rodent bioassay to predict carcinogenicity of environmental compounds. Here, we review the progress in the development and use of transgenic mouse models specifically for the purpose of carcinogenicity and mutagenicity testing.
Vijg
J
J
Harvard Medical School and Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
van Steeg
H
H
D000818:Animals; D001681:Biological Assay / Q000379:methods* / Q000639:trends*; D015197:Carcinogenicity Tests / Q000379:methods / Q000639:trends; D004195:Disease Models, Animal; D051379:Mice; D008822:Mice, Transgenic / Q000235:genetics*; D009154:Mutation / Q000235:genetics; D009374:Neoplasms, Experimental / Q000235:genetics*