Column switching achiral/chiral separation of the stereoisomers of 2-(S)-[3,5-bis (trifluoromethyl)benzyl-oxy]4-[(3-(5-oxo-1-H,4H-1,2,4- triazolo)methyl]-3-(S)-phenylmorpholine in plasma.
Merck Research Laboratories, Department of Drug Metabolism, West Point, Pennsylvania 19486, USA.
J
J
Zagrobelny
B K
BK
Matuszewski
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004285:Dogs; D005260:Female; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous; D008297:Male; D009025:Morpholines / Q000008:administration & dosage / Q000097:blood*; D064729:Neurokinin-1 Receptor Antagonists; D013237:Stereoisomerism
C099406:L 742694; D009025:Morpholines; D064729:Neurokinin-1 Receptor Antagonists