Thimerosal positivities: the role of organomercury alkyl compounds.
Contact allergy to thimerosal (TH) has not been considered a marker for mercury allergy, since there is a low degree of cross-sensitivity to inorganic as well as to organic mercury salts. 40 subjects, who previously gave a positive patch test reaction only to thimerosal 0.1% pet. (Hermal), when simultaneously repatch-tested to solutions containing TH, mersalyl acid, p-amino-phenylmercuric acid, mercuric acetate and thiosalicylic acid, respectively, gave positive reactions only to TH. 36 out of 40 subjects were divided into 2 groups of 18 subjects and simultaneously repatch-tested to solutions containing TH, methylmercury chloride (MeHgCl), thiosalicylic acid, and, ethylmercury chloride (EtHgCl), respectively. EtHgCl was tested in the 1st group at 0.031% and in the 2nd group at 0.015%. The results showed that all subjects gave concomitant positive reactions to TH, EtHgCl and MeHgCl. EtHgCl 0.031% gave a higher number of reactions than EtHgCl 0.015%, underlining the rôle of the solvent in these reactions. Patch test results in 300 consecutive patients to a standard series, to which MeHgCl was added, showed that MeHgCl and TH were never able to give isolated positive reactions, and that the concomitant positive reactions occurred in only 3.6% of subjects. In conclusion, our data seem to suggest that the positive reactions to TH found in our patients were due to EtHgCl, and that the structural similarities with MeHgCl were so close that the skin reacted against each as if they were identical.
Santucci
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San Gallicano Institute, Roma, Italy.
Cannistraci
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Cristaudo
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Camera
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Picardo
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D000478:Alkylation; D003429:Cross Reactions; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000209:etiology*; D004202:Disinfectants / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D005034:Ethylmercuric Chloride / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry; D005069:Evaluation Studies as Topic; D005659:Fungicides, Industrial / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry; D006801:Humans; D008627:Mercuric Chloride / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry; D008634:Mersalyl / Q000008:administration & dosage / Q000737:chemistry / Q000276:immunology; D008767:Methylmercury Compounds / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry; D009941:Organomercury Compounds / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry; D010328:Patch Tests / Q000592:standards; D011310:Preservatives, Pharmaceutical / Q000008:administration & dosage / Q000009:adverse effects* / Q000737:chemistry; D012867:Skin / Q000187:drug effects / Q000473:pathology; D013849:Thimerosal / Q000008:administration & dosage / Q000009:adverse effects* / Q000737:chemistry
D004202:Disinfectants; D005659:Fungicides, Industrial; D008767:Methylmercury Compounds; D009941:Organomercury Compounds; D011310:Preservatives, Pharmaceutical; D013849:Thimerosal; D008627:Mercuric Chloride; D008634:Mersalyl; D005034:Ethylmercuric Chloride