Salvador II strain of Plasmodium vivax in Aotus monkeys and mosquitoes for transmission-blocking vaccine trials.
Infections with the Salvador II strain of Plasmodium vivax in Aotus lemurinus griseimambra monkeys were fed upon by Anopheles freeborni mosquitoes. Periods of mosquito infectivity were determined to establish a model system for the testing of transmission-blocking vaccines. The highest levels of mosquito infection were associated with the ascending asexual parasitemia after reaching 1,000/microl, and before the peak asexual parasite count. Sporozoite-induced infections were more infectious than were trophozoite-induced infections. Secondary episodes of parasitemia were also infectious, indicating the lack of development of naturally developing transmission-blocking immunity to this strain of P. vivax in splenectomized Aotus monkeys following single infections.
Division of Parasitic Diseases and Animal Resources Branch, Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Chamblee, Georgia 30341-3724, USA.
W E
WE
Collins
B B
BB
Richardson
C L
CL
Morris
J S
JS
Sullivan
G G
GG
Galland
D000818:Animals; D000852:Anopheles / Q000469:parasitology*; D016645:Aotidae / Q000469:parasitology*; D004195:Disease Models, Animal; D004544:El Salvador; D007303:Insect Vectors / Q000469:parasitology*; D016780:Malaria, Vivax / Q000469:parasitology* / Q000517:prevention & control / Q000635:transmission; D018512:Parasitemia / Q000469:parasitology* / Q000517:prevention & control / Q000635:transmission; D010966:Plasmodium vivax / Q000145:classification* / Q000254:growth & development / Q000276:immunology; D016052:Protozoan Vaccines; D012189:Retrospective Studies; D013156:Splenectomy; D013997:Time Factors
D016052:Protozoan Vaccines