Two cases of glufosinate poisoning with late onset convulsions.
Glufosinate ammonium (GLA), the active ingredient in the non-selective herbicide BASTA (18.5% GLA), is a phosphinic acid analogue of glutamic acid. We report 2 cases of GLA poisoning with late onset convulsions and increased serum CK in spite of low blood concentrations of GLA after hemodialysis. A 69-y-old female was admitted to the emergency department after taking 500 ml of BASTA. On arrival she was conscious, and gut decontamination, hemodialysis and hemoperfusion were performed. However, 8 1/2 hours after ingestion, general convulsions occurred. Her serum OK increased to a peak of 24,900 IU/L on the third day of admission. An 87-y-old male was admitted to the emergency department 3 1/2 hours after taking 200 ml of BASTA and receiving gastric lavage at a local emergency room. On arrival he was conscious, and serial activated charcoal and hemodialysis was performed. Blood concentration of GLA after hemodialysis decreased from 1.56 micrograms/ml to 0.68 micrograms/ml. Thirty hours after admission he had general convulsions. GLA was not detected in the cerebrospinal fluid 6 h after the convulsions. His serum CK increased to a peak of 17,870 IU/L on the fifth day of admission.
Tanaka
J
J
Department of Emergency and Critical Care Medicine, Hidaka Hospital, Gunma, Japan.
Yamashita
M
M
Yamashita
M
M
Matsuo
H
H
Yamamoto
T
T
D000368:Aged; D000369:Aged, 80 and over; D000613:Aminobutyrates / Q000097:blood / Q000506:poisoning*; D000681:Amylases / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006464:Hemoperfusion; D006540:Herbicides / Q000097:blood / Q000506:poisoning*; D006801:Humans; D008297:Male; D011041:Poisoning / Q000628:therapy; D006435:Renal Dialysis; D012640:Seizures / Q000097:blood / Q000139:chemically induced*; D013406:Suicide, Attempted
D000613:Aminobutyrates; D006540:Herbicides; C003121:phosphinothricin; D003402:Creatine Kinase; D000681:Amylases