A dielectric method for measuring early and late reactions in irradiated human skin.
OBJECTIVE
To measure the dielectric constant of irradiated human skin in order to test the feasibility of the dielectric measurements in the quantitation of acute and late radiation reactions.


METHODS
The dielectric constant of irradiated breast skin was measured at an electromagnetic frequency of 300 MHz in 21 patients during postmastectomy radiotherapy. The measurements were performed with an open-ended coaxial line reflection method. The irradiation technique consisted of an anterior photon field to the lymph nodes and a matched electron field to the chest wall using conventional fractionation of five fractions/week to 50 Gy. Fourteen out of the 21 patients were remeasured 2 years later and the skin was palpated for subcutaneous fibrosis.


RESULTS
At 5 weeks the dielectric constant had decreased by 31 and 39% for the investigated skin sites of the photon and electron fields, respectively. There was a statistically significant inverse correlation between the mean dielectric constant and the clinical score of erythema. An unexpected finding was a decrease of the dielectric constant of the contralateral healthy skin during radiotherapy. Two years later a statistically significant positive correlation was found between the dielectric constant at the irradiated skin sites and the clinical score of subcutaneous fibrosis.


CONCLUSIONS
Dielectric measurements non-invasively yield quantitative information concerning radiation-induced skin reactions.
Department of Oncology, Kuopio University Hospital, Finland.
J
J
Nuutinen
T
T
Lahtinen
M
M
Turunen
E
E
Alanen
M
M
Tenhunen
T
T
Usenius
R
R
Kolle
D000328:Adult; D000368:Aged; D001823:Body Composition / Q000528:radiation effects*; D001943:Breast Neoplasms / Q000532:radiotherapy / Q000601:surgery; D004307:Dose-Response Relationship, Radiation; D017097:Electric Impedance; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015409:Mastectomy, Radical; D008875:Middle Aged; D011184:Postoperative Period; D011855:Radiodermatitis / Q000175:diagnosis / Q000503:physiopathology*; D012867:Skin / Q000503:physiopathology* / Q000528:radiation effects