The effect of subclinical selenium toxicosis on pregnant beef cattle.
A field investigation conducted by the South Dakota Animal Disease Research and Diagnostic Laboratory suggested that subclinical selenium toxicosis in pregnant cows may have contributed to an outbreak of aborted/stillborn calves in a high-selenium region of South Dakota. This study was undertaken to evaluate the relationship between abortion and subclinical selenium toxicosis in the dam and to assess the effects of subclinical selenium toxicosis on the bovine immune system. Fifteen pregnant cows were fed diets containing 0.25 (control), 6.0, and 12.0 ppm selenium beginning at 80-110 days gestation. Although selenium toxicosis has been reported to cause abortion, this study failed to reproduce abortions. A single cow in the 12-ppm selenium treatment group gave birth to a weak calf, which subsequently died. This calf had myocardial lesions consistent with those described for selenium toxicosis and had hepatic selenium levels of 9.68 ppm (wet weight). Elevated dietary selenium resulted in the depression of several leukocyte function parameters in pregnant cows. A statistically significant depression in forced antibody response was identified in both selenium-supplemented groups. A significantly diminished mitogenic response to concanavalin A and pokeweed mitogen was also observed in the 12-ppm selenium group. Although a similar pattern of depression was also observed with phytohemagglutinin, differences were not significant. These findings indicate that even in the absence of clinical alkali disease, elevated selenium levels may adversely affect both pregnancy outcome and the bovine immune system.
Department of Veterinary Science, South Dakota State University, Brookings 57007, USA.
M J
MJ
Yaeger
R D
RD
Neiger
L
L
Holler
T L
TL
Fraser
D J
DJ
Hurley
I S
IS
Palmer
D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D000917:Antibody Formation; D001707:Biopsy, Needle; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000503:physiopathology*; D002478:Cells, Cultured; D005260:Female; D006197:Hair / Q000737:chemistry; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D011041:Poisoning / Q000276:immunology / Q000503:physiopathology / Q000662:veterinary*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology / Q000503:physiopathology / Q000662:veterinary*; D012643:Selenium / Q000032:analysis / Q000493:pharmacokinetics / Q000506:poisoning*
D012643:Selenium