Suppression of HIV-2 replication by HIV-1 gag mutants.
Gag gene mutants of human immunodeficiency virus type 1 (HIV-1) were analyzed for their potentials of inhibiting the replication of wild-type (wt) HIV-2, the second AIDS virus, in a single-round of viral replication. Of twenty-two HIV-1 gag mutants examined, seven were found to efficiently interfere with the replication of wt HIV-2. Some mutants, which can suppress the replication of wt HIV-1, did not show this inhibitory effect. These mutants were defective at the late phase of viral replication. A mutant designated NL-C1a was demonstrated to be very effective against the replication of HIV-1 and HIV-2 in monocytic cells as well as in lymphocytic cells.
Shimano
R
R
Department of Virology, The University of Tokushima School of Medicine, Tokushima, 770-8503, Japan.
Inubushi
R
R
Fukumori
T
T
Tamaki
M
M
Oshima
Y
Y
Kawamura
M
M
Adachi
A
A
D015496:CD4-Positive T-Lymphocytes / Q000821:virology; D015683:Gene Products, gag / Q000235:genetics* / Q000494:pharmacology; D017930:Genes, Reporter / Q000235:genetics; D015750:Genes, gag / Q000235:genetics; D015316:Genetic Therapy; D016655:HIV Core Protein p24 / Q000235:genetics / Q000494:pharmacology; D015497:HIV-1 / Q000235:genetics*; D015498:HIV-2 / Q000235:genetics*; D006801:Humans; D009000:Monocytes / Q000821:virology; D009154:Mutation / Q000235:genetics; D013489:Suppression, Genetic / Q000235:genetics*; D014764:Viral Proteins / Q000235:genetics / Q000494:pharmacology
D015683:Gene Products, gag; D016655:HIV Core Protein p24; D014764:Viral Proteins