Antimyosin scintigraphy compared with magnetic resonance imaging in inflammatory myopathies.
OBJECTIVE
To compare indium In 111 altumomab pentetate-labeled antimyosin scintigraphy with magnetic resonance imaging (MRI) in the diagnosis and follow-up of patients with myositis.


METHODS
Sixteen patients with polymyositis and 1 patient with dermatomyositis, all verified with biopsy samples, were examined during diagnostic evaluation with antimyosin antibody scintigraphy and low-field MRI of the thighs and calves using T1- and T2-weighted sequences. Both examinations were repeated 6 to 22 months after therapeutic intervention with antiinflammatory drugs. The performance of the 2 methods for the assessment of the severity of muscle inflammation was evaluated using comparison with clinical examination and the serum creatine kinase level.


RESULTS
At diagnosis all patients had increased uptake of antimyosin antibody in the thighs and/or calves. In T2-weighted MRI images, increased signal intensity changes reflecting intramuscular edema and inflammation were seen in all patients in at least 1 muscle group in the thighs or calves. After anti-inflammatory drug therapy, the mean uptake of antibody and the mean signal intensity changes in T2-weighted MRI had decreased. However, in T1-weighted MRI the signal intensity changes reflecting intramuscular fatty degeneration were more pronounced in the follow-up study. The level of serum creatine kinase had decreased markedly by the second examination except in 1 patient who also had more accumulation of antibody in the calves after than before treatment. The clinical condition improved in 8 patients and remained unchanged in 9 patients.


CONCLUSIONS
Antimyosin scintigraphy and T2-weighted MRI are feasible tools for the detection and follow-up of lesions in patients with myositis. Scintigraphy findings correlate with serum creatine kinase activity and seem to reflect disease activity better than T2-weighted MRI changes, whereas secondary degenerative intramuscular lesions are only detectable using T1-weighted MRI.
Department of Neurology, Institute of Neurosciences, Helsinki University Central Hospital, Finland.
M
M
Löfberg
K
K
Liewendahl
A
A
Lamminen
O
O
Korhola
H
H
Somer
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal; D003402:Creatine Kinase / Q000097:blood; D003882:Dermatomyositis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000201:enzymology; D006801:Humans; D007205:Indium Radioisotopes; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009218:Myosins / Q000276:immunology*; D017285:Polymyositis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000201:enzymology; D011237:Predictive Value of Tests; D011877:Radionuclide Imaging; D018709:Statistics, Nonparametric
D000911:Antibodies, Monoclonal; D007205:Indium Radioisotopes; D003402:Creatine Kinase; D009218:Myosins