[Studies on complex chromosomal translocation and their relevance to clinical prognosis in acute promyelocytic leukemia].
OBJECTIVE
To study the relationship between the complex chromosome translocation in acute promyelocytic leukemia(APL, M3) and clinical therapy and prognosis.


METHODS
Chromosome translocation and PML-RAR fusion transcript in three APL patients were studied by using karyotypic analysis, fluorescence in situ hybridization and reverse transcriptase/polymerase chain reaction.


RESULTS
The findings revealed that all these cases had PML/RAR A gene rearrangement. Apart from the chromosomes 15 and 17 involved in the translocation, other multiple chromosomes including 5, 11, 16, 22 were also implicated in complex translocations, which to some extent seemed to be related with clinical prognosis.


CONCLUSIONS
This study provides additional information for monitoring clinical therapy and prognostic evaluation.
Su
X
X
Shanghai Institute of Hematology and Ruijin Hospital, Shanghai Second Medical University, Shanghai, 200025 P. R. China. zchen@ms.stn.sh.cn
He
K
K
Niu
C
C
Gu
B
B
Cao
Q
Q
Chen
Z
Z
Chen
S
S
D000328:Adult; D002880:Chromosomes, Human, Pair 11; D002884:Chromosomes, Human, Pair 15; D002885:Chromosomes, Human, Pair 16; D002886:Chromosomes, Human, Pair 17; D002892:Chromosomes, Human, Pair 22; D002895:Chromosomes, Human, Pair 5; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000235:genetics* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D014178:Translocation, Genetic