Matrix metalloproteinases: the clue to intervertebral disc degeneration?
METHODS
A review of the current literature on the role of matrix metalloproteinases in intervertebral disc degeneration.


OBJECTIVE
To detail the characteristics of matrix metalloproteinases (classification, structure, substrate specificity and regulation) and to report previous studies of intervertebral discs.


BACKGROUND
Degeneration of the intervertebral disc, a probable prerequisite to disc herniation, is a complex phenomenon, and its physiopathologic course remains unclear. Matrix metalloproteinases probably play an important role but have received sparse attention in the literature.


METHODS
A systematic review of studies reporting a role of matrix metalloproteinases in intervertebral disc degeneration.


RESULTS
In several studies, investigators have reported the presence of proteolytic enzymes from disc culture systems and disc tissue extracts in degenerated human intervertebral discs, especially collagenase-1 (MMP-1) and stromelysin-1 (MMP-3). The matrix metalloproteinases are regulated by specific inhibitors (tissue inhibitors of metalloproteinases, or TIMPS), cytokines (interleukin-1), and growth factors.


CONCLUSIONS
This field of application is of particular interest because conventional treatments are disappointing in chronic low back pain. Clinical trials with specific inhibitors of metalloproteinases are beginning in osteoarthritis.
Department of Rheumatology, University of Manchester, United Kingdom.
P
P
Goupille
M I
MI
Jayson
J P
JP
Valat
A J
AJ
Freemont
D005109:Extracellular Matrix / Q000201:enzymology; D006801:Humans; D007403:Intervertebral Disc / Q000201:enzymology* / Q000473:pathology; D007405:Intervertebral Disc Displacement / Q000201:enzymology / Q000209:etiology; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*
D008666:Metalloendopeptidases