Dipyrone, a novel anticonvulsant agent? Insights from three experimental epilepsy models.
Dipyrone, a non-steroidal anti-inflammatory agent, was anticonvulsant in three experimental epilepsy models. At a dose of 300 mg/kg i.p., dipyrone blocked the maximal hind limb extension in the electroshock model in Wistar rats, the tonic-clonic component of acute sound-induced seizures and the limbic component of audiogenic kindling in genetically susceptible Wistar-derived rats, all in 100% of the animals. In the electroshock model higher doses (400 and 500 mg/kg) were also effective but lower doses (100 and 200 mg/kg) were not. In this model dipyrone had no effect on the recovery of the righting reflex and intensified the postictal antinociception in a dose-dependent manner. Other non-steroidal anti-inflammatory agents such as indomethacin, diclofenac and aspirin had no anticonvulsant effect in the electroshock-induced seizures.
Department of Physiology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte MG, Brazil.
M C
MC
Doretto
N
N
Garcia-Cairasco
N J
NJ
Pimenta
D A
DA
Souza
M A
MA
Tatsuo
D000161:Acoustic Stimulation; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D000927:Anticonvulsants / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D004177:Dipyrone / Q000494:pharmacology*; D004597:Electroshock; D005260:Female; D007696:Kindling, Neurologic; D010147:Pain Measurement / Q000187:drug effects; D004856:Postural Balance / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012018:Reflex / Q000187:drug effects; D012640:Seizures / Q000235:genetics / Q000517:prevention & control*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000927:Anticonvulsants; D004177:Dipyrone