Enzyme models: design and selection.
There are two approaches to the discovery of enzyme mimics, that is identifying molecules that are able to bind substrate(s) and then catalyse reactions. The first approach, often inspired by enzymes themselves, utilises chemical knowledge and experience to design the catalyst. The other approach is to create a library and select the best host of a transition state analogue of the required reaction.
Rowan
S J
SJ
Cambridge Centre for Molecular Recognition, University Chemical Laboratory, Lensfield Road, Cambridge, CB2 1EW, UK.
Sanders
J K
JK
D001483:Base Sequence; D001665:Binding Sites; D002384:Catalysis; D015195:Drug Design; D004798:Enzymes / Q000737:chemistry* / Q000378:metabolism*; D008956:Models, Chemical; D008958:Models, Molecular; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D019151:Peptide Library; D011487:Protein Conformation; D016337:RNA, Catalytic / Q000737:chemistry / Q000378:metabolism
D004798:Enzymes; D019151:Peptide Library; D016337:RNA, Catalytic