Chemokine receptors and the clinical course of HIV-1 infection.
For several years, the cellular basis behind the differences in HIV-1 tropism and the species specificity of HIV-1 has remained unclear. Since the discovery that chemokine receptors are essential cofactors for entry of HIV-1 into cells, tremendous progress has been made in the understanding of the role played by co-receptors in HIV-1 biological variability, HIV-1 transmission and AIDS pathogenesis.
Dept of Clinical Viro-Immunology, University of Amsterdam, The Netherlands. clbkvi@xs4all.nl
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de Roda Husman
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Schuitemaker
D015658:HIV Infections / Q000503:physiopathology* / Q000628:therapy / Q000635:transmission / Q000821:virology; D015497:HIV-1 / Q000276:immunology / Q000472:pathogenicity / Q000502:physiology*; D006801:Humans; D010641:Phenotype; D019707:Receptors, Chemokine / Q000276:immunology / Q000502:physiology*; D018523:Tropism / Q000276:immunology
D019707:Receptors, Chemokine