Hydroxyurea and hemin affect both the transcriptional and post-transcriptional mechanisms of some globin genes in human adult erythroid cells.
First Department of Medicine, University of Athens, Laikon Hospital, Greece.
P
P
Kollia
E
E
Fibach
M
M
Politou
C T
CT
Noguchi
A N
AN
Schechter
D
D
Loukopoulos
D000328:Adult; D002467:Cell Nucleus / Q000378:metabolism; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D005091:Exons; D005786:Gene Expression Regulation / Q000187:drug effects*; D005914:Globins / Q000096:biosynthesis* / Q000235:genetics; D006427:Hemin / Q000494:pharmacology*; D006801:Humans; D006918:Hydroxyurea / Q000494:pharmacology*; D012326:RNA Splicing; D014158:Transcription, Genetic / Q000187:drug effects*
D006427:Hemin; D005914:Globins; D006918:Hydroxyurea