Cellular immunity and immunotherapy against deoxyribonucleic acid virus-induced tumors.
An important role in the immune defense against deoxyribonucleic acid virus induced tumors is mediated by T-cells, as is evident from aetiological, animal model, and clinical data. In this review the most recent observations in this field are described for three prominent members of this family of viruses, namely human papillomavirus associated with human cervical cancer, human adenovirus associated with lung infections in humans and tumors in rodents, and simian virus 40 associated with rodent tumors and human mesothelioma, osteosarcoma and ependymoma.
Macedo
M F
MF
Cancer Immunology Program, Cardinal Bernardin Cancer Center, Loyola University of Chicago, Maywood, IL 60153, USA.
Velders
M P
MP
Nieland
J D
JD
Rudolf
M P
MP
Weijzen
S
S
Da Silva
D M
DM
Franke
A
A
Holt
G
G
Loviscek
K
K
Carbone
M
M
Kast
W M
WM
D000818:Animals; D004263:DNA Tumor Viruses / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007167:Immunotherapy; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology; D014412:Tumor Virus Infections / Q000276:immunology* / Q000628:therapy*