Synthesis and inhibitory activity of novel tri- and tetracyclic quinolines against topoisomerases.
A series of isoindolo[2,1-a]- and pyrrolo[1,2-a]quinolines were designed and synthesized for DNA-gyrase and topoisomerase-II inhibition studies. Some of the compounds showed significant activity against the enzymes.
Sui
Z
Z
R. W. Johnson Pharmaceutical Research Institute, Drug Discovery, Raritan, NJ 08869, USA.
Altom
J
J
Nguyen
V N
VN
Fernandez
J
J
Bernstein
J I
JI
Hiliard
J J
JJ
Barrett
J F
JF
Podlogar
B L
BL
Ohemeng
K A
KA
D001419:Bacteria / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D059005:Topoisomerase II Inhibitors
D004791:Enzyme Inhibitors; D007211:Indoles; D011758:Pyrroles; D011804:Quinolines; D059005:Topoisomerase II Inhibitors