An unusual mechanism for ligand antagonism.
The ratio of late to early events stimulated by the mast cell receptor for immunoglobulin E (IgE) correlated with the affinity of a ligand for the receptor-bound IgE. Because excess receptors clustered by a weakly binding ligand could hoard a critical initiating kinase, they prevented the outnumbered clusters engendered by the high-affinity ligands from launching the more complete cascade. A similar mechanism could explain the antagonistic action of some peptides on the activation of T cells.
Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892-1820, USA.
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D019297:2,4-Dinitrophenol / Q000276:immunology; D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D000915:Antibody Affinity; D000937:Antigen-Antibody Reactions; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000378:metabolism; D003619:Dansyl Compounds; D004792:Enzyme Precursors / Q000378:metabolism; D051418:Focal Adhesion Kinase 2; D006241:Haptens / Q000276:immunology* / Q000378:metabolism; D007073:Immunoglobulin E / Q000276:immunology / Q000378:metabolism*; D047908:Intracellular Signaling Peptides and Proteins; D008024:Ligands; D008407:Mast Cells / Q000276:immunology*; D019950:Mitogen-Activated Protein Kinase 1; D015513:Oncogene Proteins / Q000378:metabolism; D010766:Phosphorylation; D019000:Phosphotyrosine / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D051381:Rats; D011940:Receptor Aggregation; D017455:Receptors, IgE / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction; D000072377:Syk Kinase; D013601:T-Lymphocytes / Q000276:immunology; D014407:Tumor Cells, Cultured
D048868:Adaptor Proteins, Signal Transducing; D003619:Dansyl Compounds; D004792:Enzyme Precursors; D006241:Haptens; D047908:Intracellular Signaling Peptides and Proteins; D008024:Ligands; C078332:Nck protein; D015513:Oncogene Proteins; D017455:Receptors, IgE; D019000:Phosphotyrosine; D007073:Immunoglobulin E; D011505:Protein-Tyrosine Kinases; D051418:Focal Adhesion Kinase 2; C496054:Ptk2b protein, rat; D000072377:Syk Kinase; C000606898:Syk protein, rat; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D019950:Mitogen-Activated Protein Kinase 1; D019297:2,4-Dinitrophenol