Studies on dressings for mucosa of the oral cavity. Part 4: Influence of technology used in the preparation of dental xerogel dressings in the presence of acetone on their properties.
Adhesion of xerogel dressings prepared on Eudragit-E 100, methylcellulose and glycerol compositions in acetone/water mixtures, remains within the range of 317-967 g, after addition of polyvinylpyrrolidone (PVP), it increases to 633-1200 g. Dissolution time of dressings in water amounts to 6 h, in artificial gastric juice to 3 h. Addition of PVP results in decrease of the elution rate, dissolution time amounts to 2.5 h. The Kunitz protease inhibitor semi-liberation times amount to 3.3-7.6 h.
Malecka
K
K
Department of Pharmaceutical Technology, Faculty of Pharmacy, Silesian Piasts Memorial Medical Academy, Wroclaw, Poland.
Kubis
A A
AA
D000096:Acetone / Q000737:chemistry; D000180:Acrylic Resins / Q000737:chemistry*; D000268:Adhesiveness; D001458:Bandages; D005782:Gels; D009061:Mouth Mucosa; D011109:Polymethacrylic Acids; D011480:Protease Inhibitors / Q000737:chemistry; D014360:Trypsin Inhibitor, Kunitz Soybean / Q000737:chemistry
D000180:Acrylic Resins; D005782:Gels; D011109:Polymethacrylic Acids; D011480:Protease Inhibitors; D000096:Acetone; C038300:methylmethacrylate-methacrylic acid copolymer; D014360:Trypsin Inhibitor, Kunitz Soybean