Changes in pancreatic function after pancreatoduodenectomy.
BACKGROUND
The objective of this study was to compare the alterations in pancreatic function after pancreatoduodenectomy between malignant and benign diseases.


METHODS
In 34 patients who underwent pancreatoduodenectomy for pariampullary cancer (malignant group; n = 18) and benign pancreatic disorders (benign group; n = 16), exocrine and endocrine functions were analyzed before surgery, at a short-term period (< or = 2 months), and at a long-term period (>12 months) after surgery. Assessment was based on the BT-PABA excretion test, fasting blood sugar level, and oral glucose tolerance test.


RESULTS
Compared with the preoperative level, urinary PABA excretion rate in the malignant group significantly decreased on short-term follow-up but recovered on long-term follow-up. However, that in the benign group increased on long-term follow-up without showing a short-term decline. Diabetes mellitus was present in 11 (61%) of the 18 patients in the malignant group and 6 (38%) of the 16 in the benign group before surgery. Glucose tolerance improved in 6 (55%) of the 11 patients in the malignant group but in only 1 (17%) of the 6 in the benign group shortly after surgery. In the benign group, 3 (30%) of 10 patients with normal preoperative glucose tolerance became diabetic after surgery, while no patient in the malignant group developed diabetes on short-term follow-up.


CONCLUSIONS
Surgeons should pay attention to exocrine pancreatic function in patients with a periampullary cancer and to glucose metabolism in patients with benign disease over the short-term period after pancreatoduodenectomy.
Department of Surgery I, Kyushu University Faculty of Medicine, Fukuoka, Japan.
N
N
Sato
K
K
Yamaguchi
K
K
Yokohata
S
S
Shimizu
H
H
Noshiro
K
K
Mizumoto
K
K
Chijiiwa
M
M
Tanaka
D010129:4-Aminobenzoic Acid / Q000652:urine; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000378:metabolism / Q000503:physiopathology*; D010182:Pancreatic Diseases / Q000378:metabolism / Q000503:physiopathology* / Q000601:surgery; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery; D016577:Pancreaticoduodenectomy; D012189:Retrospective Studies; D062366:para-Aminobenzoates
D001786:Blood Glucose; D001798:Blood Proteins; D062366:para-Aminobenzoates; C006717:bentiromide; D010129:4-Aminobenzoic Acid