Acute femoral artery thrombosis associated with functional protein C deficiency as the presenting manifestation of acute monocytic leukemia.
Acute leukemia may be linked to disturbances of the coagulation system, which are usually due to hyperviscosity because of disseminated intravascular coagulation or a high white cell count. We report a unique case of femoral artery thrombosis as the beginning symptom of acute monocytic leukemia (M5) associated with a low level of functional protein C. The patient had multiple recurrent episodes of thrombosis with low levels of functional protein C associated with the relapse of the leukemia. A review of the literature shows that this is an extremely rare phenomenon.
Malnick
S D
SD
Department of Internal Medicine C, Kaplan Medical Center, Rehovot, Israel.
Ben-David
D
D
Shtalrid
M
M
Leichman
I
I
Schwartz
H
H
Sthoeger
Z M
ZM
D000208:Acute Disease; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D005260:Female; D005263:Femoral Artery; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000150:complications* / Q000188:drug therapy; D020151:Protein C Deficiency; D012008:Recurrence; D017131:Thrombectomy; D013927:Thrombosis / Q000209:etiology* / Q000628:therapy
D000925:Anticoagulants