Kinetics of swelling-breakdown of a W/O/W multiple emulsion: possible mechanisms for the lipophilic surfactant effect.
The properties and behavior of a W/O/W multiple emulsion formulation were analyzed during a swelling-breakdown process. Various experimental analyses, such as granulometry, rheology and conductimetry were performed, as well as a micropipette aspiration method. The predominant role of the lipophilic surfactant during the swelling phase confirmed. Two different mechanism can be proposed. Both imply the migration of the lipophilic surfactant from one interface to another and probably take place successively. The lipophilic surfactant could diffuse from the first to the second interface, thus rigidifying the membrane, or from the oily phase to the first interface, resulting in delayed coalescence of the aqueous droplets during swelling.
Laboratoire de Physique Pharmaceutique, UFR des Sciences Pharmaceutiques, Châtenay-Malabry, France.
S
S
Geiger
S
S
Tokgoz
A
A
Fructus
N
N
Jager-Lezer
M
M
Seiller
C
C
Lacombe
J L
JL
Grossiord
D004655:Emulsions; D008278:Magnesium Sulfate / Q000378:metabolism; D012995:Solubility; D013501:Surface-Active Agents / Q000494:pharmacology*
D004655:Emulsions; D013501:Surface-Active Agents; D008278:Magnesium Sulfate