Immune response to three doses of quadrivalent rotavirus vaccine: 1-year follow-up.
Twenty-eight children who received three doses of the quadrivalent rotavirus vaccine with 4 x 10(5) plaque-forming units (p.f.u.) were followed during a year after vaccination. Serum samples were obtained and evaluated for rotavirus IgA and neutralizing antibodies against vaccine and human rotavirus strains. At the end of the study, up to 61% of the children showed an increase in circulating IgA antibody levels. Nearly all of the vaccinated children increased their neutralizing antibody titres against the vaccine strains, and 25-54% against human rotavirus serotypes. After comparing the vaccinees with a population of children naturally infected with serotype G1 in the same study area, we conclude that three doses of 4 x 10(5) p.f.u. of the quadrivalent vaccine should prepare the child against future severe rotavirus diarrhea.
Instituto de Biomedicina, Universidad Central de Venezuela, Caracas, Venezuela.
J
J
Vázquez
Y
Y
Boher
M
M
Pérez
M J
MJ
Guntiñas
A M
AM
Rojas
D000914:Antibodies, Viral / Q000096:biosynthesis*; D000937:Antigen-Antibody Reactions; D004306:Dose-Response Relationship, Immunologic; D005500:Follow-Up Studies; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007223:Infant; D012400:Rotavirus Infections / Q000276:immunology*; D012703:Serotyping; D014687:Venezuela; D014765:Viral Vaccines / Q000276:immunology*
D000914:Antibodies, Viral; D007070:Immunoglobulin A; D014765:Viral Vaccines