Effect of sucrose feeding on glucose tolerance and their relationship with lipid metabolism in maternal and fetal livers in rat.
This study was carried out to determine a possible relationship between hepatic acetyl-coenzyme A carboxylase EC 6.4.1.2 (ACC) activity in dam and fetus at 15-day and 19-day of gestation and the glucose tolerance in pregnant rats fed on the sucrose diet compared with the rats feed on the dextrin diet. Sucrose feeding increases ACC activity in livers of dam and fetus and the level of circulating LDL + VLDL cholesterol in the dam. Those findings are correlated with the high serum glucose and insulin concentrations observed in the sucrose-fed rats following oral glucose challenge in both 15-day and 19-day pregnant rats compared with the dextrin-fed rats. These results suggest that sucrose feeding to pregnant rats modified the hepatic lipid metabolism in them and in their fetus, associated with the changes in serum glucose and insulin levels.
Laboratory of Biological Chemistry, Faculty of Chemistry, Biochemistry and Pharmacy, National University of San Luis, Argentina.
L
L
Oliveros
E
E
Callegari
M S
MS
Giménez
D000103:Acetyl-CoA Carboxylase / Q000032:analysis / Q000096:biosynthesis; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D003912:Dextrins / Q000008:administration & dosage / Q000378:metabolism; D019422:Dietary Sucrose / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D005333:Fetus / Q000378:metabolism*; D005865:Gestational Age; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D007328:Insulin / Q000097:blood; D050356:Lipid Metabolism; D008099:Liver / Q000196:embryology / Q000378:metabolism*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D003912:Dextrins; D019422:Dietary Sucrose; D007328:Insulin; D014280:Triglycerides; D002784:Cholesterol; D000103:Acetyl-CoA Carboxylase; D005947:Glucose