Repeatability and reproducibility estimates from collaborative studies based on total concentration of trace analytes.
In the process of validating a given analytical method for the total concentration of a trace analyte, the precision indicators, repeatability and reproducibility, are obtained from a collaborative study of the method based on a standard one-way completely randomized model. This report discusses the shortcomings of the statistical models used in such studies, defines the component makeup for estimates of the repeatability and reproducibility variances based on these models, and considers suggestions offered as new policy regarding method performance based on total concentration.
U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204, USA.
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McClure
D000348:Aflatoxins / Q000032:analysis; D000465:Algorithms; D002273:Carcinogens / Q000032:analysis; D005504:Food Analysis; D008832:Microchemistry / Q000706:statistics & numerical data*; D015233:Models, Statistical; D011786:Quality Control; D015203:Reproducibility of Results
D000348:Aflatoxins; D002273:Carcinogens