Enhanced transdermal delivery of AZT (Zidovudine) using iontophoresis and penetration enhancer.
The effect of current, its magnitude and penetration enhancers (propylene glycol/oleic acid) on the transdermal flux of AZT (Zidovudine) across hairless mouse skin was studied and the results were compared. The in vitro iontophoretic flux from AZT solution increased to about 5-40 fold that obtained by passive diffusion, depending on the magnitude of current density. When the donor side was karaya gum matrix, instead of solution, the flux enhancement effect by iontophoresis was much smaller. Incorporation of penetration enhancers into the matrix increased the passive flux 2-50 fold, depending on the amount of penetration enhancers in the matrix. These enhancers worked synergistically with iontophoresis in the transdermal transport: a much larger flux than that expected from a simple additive effect was observed. Electrical resistance data from our previous work is utilized to further discuss this synergistic effect.
Oh
S Y
SY
College of Pharmacy, Sookmyung Women's University, Seoul, Korea.
Jeong
S Y
SY
Park
T G
TG
Lee
J H
JH
D000279:Administration, Cutaneous; D000818:Animals; D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000378:metabolism; D002021:Buffers; D016503:Drug Delivery Systems; D005260:Female; D005990:Glycerol; D007478:Iontophoresis / Q000379:methods; D007618:Karaya Gum; D051379:Mice; D008812:Mice, Hairless; D019301:Oleic Acid; D019946:Propylene Glycol; D018894:Reverse Transcriptase Inhibitors / Q000008:administration & dosage* / Q000378:metabolism; D012869:Skin Absorption / Q000187:drug effects / Q000502:physiology; D015215:Zidovudine / Q000008:administration & dosage* / Q000378:metabolism
D019380:Anti-HIV Agents; D002021:Buffers; D018894:Reverse Transcriptase Inhibitors; D019301:Oleic Acid; D015215:Zidovudine; D019946:Propylene Glycol; D007618:Karaya Gum; D005990:Glycerol