Effects of La3+ on lipid fluidity and structural transitions in human erythrocyte membranes.
The effects of La3+ on the structure and function of human erythrocyte membranes were investigated by fluorescence polarization, spin-labeled electron spin resonance (ESR) and differential scanning calorimetry (DSC). The results showed that increasing concentrations of La3+ inhibited (Na(+) + K+)-ATPase and Mg(2+)-ATPase activities. La3+ lowered the lipid fluidity of erythrocyte membranes and induced structural transitions in erythrocyte membranes.
Laboratory of Rare Earth Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, China.
X M
XM
Li
J Z
JZ
Ni
J W
JW
Chen
F
F
Hwang
D017301:Ca(2+) Mg(2+)-ATPase / Q000037:antagonists & inhibitors*; D002152:Calorimetry, Differential Scanning; D004578:Electron Spin Resonance Spectroscopy; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D006801:Humans; D007811:Lanthanum / Q000494:pharmacology*; D008560:Membrane Fluidity / Q000187:drug effects*; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*; D013050:Spectrometry, Fluorescence
D007811:Lanthanum; D017301:Ca(2+) Mg(2+)-ATPase; D000254:Sodium-Potassium-Exchanging ATPase