Salivary and gastric fluid secretory immunoglobulin A and free secretory component concentrations in children with Helicobacter pylori-positive gastritis.
The concentrations of secretory IgA (sIgA) in the saliva and the concentrations of free secretory components (FSC) both in the saliva and gastric fluid of patients with Helicobacter pylori HP-positive gastritis and of a control group with functional recurrent abdominal pain (RAP) were measured in order to determine whether there is a deficiency of these non-specific local defence factors in children with HP infection. Eighteen patients with HP-positive gastritis and 12 children with RAP were included in the study and sIgA and FSC concentrations were analysed using the radial immunodiffusion technique. In contrast to our initial hypothesis, the concentrations of FSC in saliva and gastric fluid and sIgA in saliva of patients with HP infection showed no significant difference when compared with children who do not have an organic disease and HP infection. It is suggested that these local defence factors are not involved in the pathogenesis of HP-positive gastritis.
Ege University, Faculty of Medicine, Department of Pediatrics, Izmir, Turkey.
N
N
Kutukculer
S
S
Aydogdu
S
S
Caglayan
R V
RV
Yagci
D015746:Abdominal Pain / Q000276:immunology; D016022:Case-Control Studies; D015984:Causality; D002648:Child; D005260:Female; D005750:Gastric Juice / Q000737:chemistry*; D005756:Gastritis / Q000276:immunology* / Q000382:microbiology*; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori; D006801:Humans; D018928:Immunity, Mucosal / Q000276:immunology; D007071:Immunoglobulin A, Secretory / Q000032:analysis*; D008297:Male; D012008:Recurrence; D012463:Saliva / Q000737:chemistry*; D012635:Secretory Component / Q000032:analysis*
D007071:Immunoglobulin A, Secretory; D012635:Secretory Component