High prevalence of parvovirus B19 IgG antibodies among Dutch hemophilia patients.
OBJECTIVE
Human parvovirus B19 is a potential risk to hemophiliac patients receiving blood products.


METHODS
To determine the prevalence of the corresponding antibody in patients with hemophilia A or B von Willebrand's disease, we tested 326 hemophilia patients for anti-B19 IgG. The results were compared with those of 203 age-matched controls (male blood donors and children).


RESULTS
The overall prevalence of B19 IgG in the hemophilia patients was 302/326, and in the controls 123/203. Below the age of 10, hemophilia patients had a higher prevalence of B19 IgG (76%, 42/55) than the controls (23%, 11/48; p < 0.00001). In those below the age of 5 who had been treated exclusively with monoclonally purified concentrate, it made no difference whether the product was pasteurized or solvent-detergent treated. There was significantly lower incidence in patients who were rarely treated.


CONCLUSIONS
Parvovirus B19 if frequently transmitted in blood products. Existing virus-inactivating methods do not prevent transmission.
Van Creveld Clinic, University Hospital Utrecht, The Netherlands. E.MauserBunschoten@digd.AZU.nl
E P
EP
Mauser-Bunschoten
H L
HL
Zaaijer
A A
AA
van Drimmelen
S
S
de Vries
G
G
Roosendaal
H M
HM
van den Berg
P N
PN
Lelie
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000914:Antibodies, Viral / Q000097:blood; D001779:Blood Coagulation Factors / Q000009:adverse effects / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D006467:Hemophilia A / Q000097:blood / Q000453:epidemiology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D010322:Parvoviridae Infections / Q000453:epidemiology* / Q000276:immunology* / Q000635:transmission; D016732:Parvovirus B19, Human / Q000276:immunology*; D015995:Prevalence; D012307:Risk Factors; D014842:von Willebrand Diseases / Q000453:epidemiology
D000914:Antibodies, Viral; D001779:Blood Coagulation Factors; D007074:Immunoglobulin G