[Molecular characteristics of RB1 tumor suppressor gene].
RB1 tumor suppressor gene is implicated in the development of some malignancies, among which retinoblastoma is the most common; in this tumor RB1 gene is generally deleted. This gene is closely associated to the cell cycle regulation and it constitutes a molecular binding target of viral oncoproteins, which inhibits its protein product, thus interrupting cell cycle progression. This paper describes its molecular features, in order to identify its mutations.
Boquete
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Hospital Municipal de Oncología María Curie, Buenos Aires, Argentina.
D016161:Genes, Retinoblastoma; D016147:Genes, Tumor Suppressor / Q000235:genetics*; D006801:Humans; D012175:Retinoblastoma / Q000235:genetics*