The platelet intracellular calcium response to serotonin in subsyndromal depression.
The relationship of subsyndromal depression to syndromal depression is unclear. Increased sensitivity of platelet serotonin type 2 receptor has been reported in depression using the Fura-2 technique. The sensitivity of the platelet serotonin type 2 receptor was assessed using the Fura-2 method in 16 patients with subsyndromal depression and 14 controls. The patient group had higher numerical values of both basal and serotonin-stimulated levels of platelet intracellular calcium that did not however reach statistical significance.
Department of Psychiatry, University of the Witwatersrand Medical School, Parktown, South Africa.
M
M
Berk
V S
VS
Mitchell
H
H
Plein
D000328:Adult; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D002118:Calcium / Q000097:blood*; D003866:Depressive Disorder / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011985:Receptors, Serotonin / Q000187:drug effects*; D012701:Serotonin / Q000494:pharmacology*
D011985:Receptors, Serotonin; D012701:Serotonin; D002118:Calcium