Correlating structure and function in ATP-sensitive K+ channels.
ATP-sensitive K+ channels couple cell metabolism to electrical activity in nerve, muscle and endocrine cells, and play important roles in these tissues under both physiological and pathological conditions. The KATP channel is an octameric complex of two unrelated types of subunit: a pore-forming subunit (Kir6.2) and a regulatory subunit, the sulphonylurea receptor (SUR). This review focuses on the regulation of KATP channel activity by nucleotides and cell metabolism and considers which regulatory mechanisms are intrinsic to Kir6.2 and which are conferred by association with SUR.
Ashcroft
F M
FM
University Lab of Physiology, Oxford, UK.
Gribble
F M
FM
D018528:ATP-Binding Cassette Transporters; D000255:Adenosine Triphosphate / Q000378:metabolism; D002477:Cells / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D005809:Genes, Regulator / Q000235:genetics; D008040:Genetic Linkage; D006946:Hyperinsulinism / Q000235:genetics; D066298:In Vitro Techniques; D008954:Models, Biological; D009711:Nucleotides / Q000378:metabolism; D015221:Potassium Channels / Q000378:metabolism / Q000502:physiology*; D024661:Potassium Channels, Inwardly Rectifying; D011955:Receptors, Drug / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013453:Sulfonylurea Compounds / Q000378:metabolism; D064233:Sulfonylurea Receptors
D018528:ATP-Binding Cassette Transporters; D009711:Nucleotides; D015221:Potassium Channels; D024661:Potassium Channels, Inwardly Rectifying; D011955:Receptors, Drug; D013453:Sulfonylurea Compounds; D064233:Sulfonylurea Receptors; D000255:Adenosine Triphosphate; D000254:Sodium-Potassium-Exchanging ATPase