Glucose effects on cognition in adults with Down's syndrome.
Glucose enhances memory in a variety of individuals, including people with Alzheimer's disease. By 35 years of age, adults with Down's syndrome (DS) develop the characteristic plaques and tangles found in Alzheimer's disease, despite findings indicating that not all older DS individuals meet criteria for dementia. To examine the possibility that glucose enhances memory in adults with DS (mean age = 35 years, range = 19-55 years), adults with DS were given a battery of tests specifically designed for individuals with DS in glucose and control conditions. No participant met criteria for dementia, regardless of age. Glucose enhanced performance on tests requiring both long-term memory and auditory processing. In addition, increased age was associated with poorer performance on the majority of tests in the control condition, indicating that cognitive decline with aging may be more prevalent in DS than previously believed.
Department of Neurology, University of Virginia, USA. cm4r@virginia.edu
C A
CA
Manning
V J
VJ
Honn
W S
WS
Stone
J S
JS
Jane
P E
PE
Gold
D000328:Adult; D000367:Age Factors; D000704:Analysis of Variance; D003071:Cognition / Q000187:drug effects*; D003072:Cognition Disorders / Q000188:drug therapy / Q000209:etiology; D004311:Double-Blind Method; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D005947:Glucose / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects*; D008569:Memory Disorders / Q000188:drug therapy / Q000209:etiology; D008609:Mental Status Schedule; D008875:Middle Aged
D005947:Glucose