Tacrolimus rescue therapy for cyclosporine-induced nephrotoxicity.
Following renal transplantation, the long-term use of cyclosporine can cause nephrotoxicity. This small study of ten patients looks at the effects of tacrolismus rescue therapy over a 6-month period. After conversion to tacrolismus, renal function improved in seven patients, progressive graft dysfunction slowed and almost stabilized in two patients, and, in the remaining patient, deterioration continued and hemodialysis treatment was initiated at the end of the study period. A greater number of patients and a longer follow up are necessary to confirm these initially impressive results.
Servivio de Nefrología, Hospital Universitario Reina Sofía, Cordoba, Spain.
G
G
Hernández-Herrera
D D
DD
Castillo
R
R
Pérez
F
F
López-Rubio
P
P
Aljama
D016572:Cyclosporine / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D007674:Kidney Diseases / Q000139:chemically induced* / Q000188:drug therapy*; D016030:Kidney Transplantation; D011183:Postoperative Complications / Q000139:chemically induced* / Q000188:drug therapy*; D016559:Tacrolimus / Q000627:therapeutic use*
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D016559:Tacrolimus