Neuroprotective and thrombolytic agents: advances in stroke treatment.
Acute ischemic stroke is a complex, heterogeneous and debilitating disorder, which leads to death or disability. Recent research into the mechanism of stroke has identified a relatively short window of opportunity, during which a population of neurons surrounding the ischemic core remain viable for a number of hours following stroke onset. These penumbral neurons can be salvaged if treatment is begun within 3-6 hours following the onset of ischemia. This understanding of stroke mechanisms has lead to the development of promising new therapies currently under study. To maximize the potential benefits of these new therapies, neurologists, neuroscience nurses and other healthcare professionals need to assume the responsibility of effectively implementing treatment and to educate their peers and the public about the symptoms of stroke and the need to seek immediate medical assistance.
Stanford Stroke Center, Stanford University Medical Center, Palo Alto, CA 94304-1705, USA.
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D001921:Brain / Q000187:drug effects; D002561:Cerebrovascular Disorders / Q000188:drug therapy* / Q000401:mortality / Q000451:nursing / Q000503:physiopathology; D002986:Clinical Trials as Topic; D006801:Humans; D009474:Neurons / Q000187:drug effects; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D015996:Survival Rate; D015912:Thrombolytic Therapy / Q000451:nursing*
D018696:Neuroprotective Agents