Acute ethanol induces c-fos immunoreactivity in GABAergic neurons of the central nucleus of the amygdala.
The central nucleus of the amygdala (CNA) is a component of the brain reward pathway which is believed to represent an anatomical substrate for drugs of abuse. Previous studies have shown that acute ethanol administration induces the expression of c-fos in the CNA of rat brains. We report here, that over 70% of these c-fos immunoreactive neurons are GABAergic. This observation provides the first anatomical evidence that GABAergic neurons of the CNA are responsive to acute ethanol exposure and suggest that the GABAergic system of the CNA is a key neuronal substrate for ethanol actions on the central nervous system.
The Scripps Research Institute, Department of Neuropharmacology, Alcohol Research Center, North Torrey Pines Road, La Jolla, CA 92037, USA. mmorales@irp.nida.nih.gov
M
M
Morales
J R
JR
Criado
P P
PP
Sanna
S J
SJ
Henriksen
F E
FE
Bloom
D000679:Amygdala / Q000166:cytology / Q000378:metabolism*; D000818:Animals; D000431:Ethanol / Q000494:pharmacology*; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008297:Male; D009474:Neurons / Q000378:metabolism*; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D016760:Proto-Oncogene Proteins c-fos; D000431:Ethanol; D005680:gamma-Aminobutyric Acid