Regulation of ion channels by cAMP-dependent protein kinase and A-kinase anchoring proteins.
Subcellular targeting of the cAMP-dependent protein kinase is achieved, in part, through association with A-kinase anchoring proteins (AKAPs). Recent evidence suggests that specific AKAPs direct the kinase to submembrane sites to facilitate phosphorylation and modulation of a variety of ion channels. A new membrane-anchored AKAP targets cAMP-dependent protein kinase to calcium channels and enhances their regulation in multiple cell types.
Department of Pharmacology, University of Washington, Seattle 98195-7280, USA.
P C
PC
Gray
J D
JD
Scott
W A
WA
Catterall
D054758:A Kinase Anchor Proteins; D048868:Adaptor Proteins, Signal Transducing; D015220:Calcium Channels / Q000502:physiology*; D020746:Calcium Channels, L-Type; D002352:Carrier Proteins / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism*; D015640:Ion Channel Gating / Q000502:physiology*; D008565:Membrane Proteins / Q000378:metabolism*; D017470:Receptors, Glutamate / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
D054758:A Kinase Anchor Proteins; C112596:AKAP7 protein, human; D048868:Adaptor Proteins, Signal Transducing; D015220:Calcium Channels; D020746:Calcium Channels, L-Type; D002352:Carrier Proteins; D008565:Membrane Proteins; D017470:Receptors, Glutamate; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases