Sensitivity and specificity of computer-assisted breast cancer detection in mammography screening.
OBJECTIVE
To evaluate a system of computer-assisted diagnosis (CAD) in mammography.


METHODS
A sample of 120 sets of two-view mammograms was examined by an expert screener, a screening radiologist, a clinical radiologist, and a CAD system. The screening and clinical radiologists examined the mammograms twice, first without and then with the help of CAD. The sample consisted of first-round screening films from a two-round population-based screening, and comprised: 32 women in whom breast cancer was detected at the first screening; 10 with cancer detected during the screening interval; 32 with cancer detected at the second screening; and 46 with normal mammograms at both screenings.


RESULTS
The expert screener, the screening radiologist, the clinical radiologist, and the CAD system detected respectively 44, 41, 34 and 37 cancers. Their respective specificities were 80%, 83%, 100% and 22%. With the help of CAD, the screening radiologist detected 1 additional cancer and the clinical radiologist detected 3; their respective specificities were 80% and 100%.


CONCLUSIONS
The sensitivity of the CAD system was satisfactory. The two radiologists helped by CAD achieved a modest increase in sensitivity with unaffected specificity. However, the CAD system by itself had a very low specificity and it needs improvement before it can be useful in mammographic screening.
Department of Diagnostic Radiology, Uppsala University Hospital, Sweden.
E
E
Thurfjell
M G
MG
Thurfjell
E
E
Egge
N
N
Bjurstam
D000328:Adult; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008327:Mammography / Q000295:instrumentation / Q000379:methods*; D008875:Middle Aged; D015588:Observer Variation; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000295:instrumentation / Q000379:methods*; D012680:Sensitivity and Specificity