Pesticide deposition in hair: preliminary results of a model study of methomyl incorporation into rabbit hair.
This work studied the incorporation of methomyl, a carbamate insecticide, into the hair of New Zealand white rabbits. A total of 600 mg methomyl was administered by drinking water over 4 mo, and acetylcholinesterase activity in serum was monitored. At the end of the dosing period, hair from the back of the rabbits was cut off, and the methomyl concentration was measured using ELISA and HPLC. A decrease of serum acetylcholinesterase occurred. The top cm of hair contained no methomyl, the second cm contained 0.9 ng/mg and the 3rd cm of hair contained 3 ng methomyl/mg. Methomyl was incorporated into the rabbit hair in a process independent of gender but dependent on the hair growth rate.
Laboratory of Toxicology, University of Crete, Iraklion, Greece.
A M
AM
Tsatsakis
M I
MI
Tutudaki
M N
MN
Tzatzarakis
K
K
Psaroudakis
G P
GP
Dolapsakis
M N
MN
Michalodimitrakis
D000110:Acetylcholinesterase / Q000097:blood; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006197:Hair / Q000378:metabolism*; D007306:Insecticides / Q000493:pharmacokinetics*; D008297:Male; D008724:Methomyl / Q000493:pharmacokinetics*; D008954:Models, Biological; D011817:Rabbits
D007306:Insecticides; D008724:Methomyl; D000110:Acetylcholinesterase