Prognostic value of tumor cell proliferation and intratumor microvessel density in advanced gastric cancer treated with curative surgery.
To clarify the prognostic value of tumor cell proliferation [proliferating cell nuclear antigen (PCNA)-positive rate assessed by anti-PCNA immunostaining] and intratumor microvessel density (/0.74 mm2, assessed by anti-CD34 immunostaining) in gastric cancer, 192 advanced gastric cancer patients who underwent curative surgery were investigated. Multivariate analysis showed that the following variables were significantly related to prognosis: age (P=0.029), depth of invasion (P=0.005), lymph node metastasis (P=0.006), lymphatic invasion (P=0.038), venous invasion (P=0.0005), PCNA-positive rate (P=0.049) and intratumor microvessel density (P=0. 011). In conclusion, tumor cell proliferation and intratumor microvessel density were independent prognostic factors in patients with advanced gastric cancer undergoing curative surgery.
First Department of Surgery, Okayama University Medical School, Okayama 700-8558, Japan.
H
H
Isozaki
K
K
Fujii
E
E
Nomura
H
H
Mabuchi
H
H
Hara
S
S
Sako
K
K
Nishiguchi
M
M
Ohtani
T
T
Tenjo
T
T
Nohara
N
N
Tanigawa
D000328:Adult; D000368:Aged; D002455:Cell Division / Q000502:physiology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000098:blood supply; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000098:blood supply* / Q000473:pathology* / Q000601:surgery
D018809:Proliferating Cell Nuclear Antigen