[Association analysis of polymorphism in angiotensin-converting enzyme gene in ischemic stroke].
Family and twins study demonstrated that genetic factors may be involved in stroke. Previously, insertion/deletion (I/D) Alu-polymorphism in the angiotensin-converting enzyme (ACE) gene has been suggested as a risk factor for some cardiovascular diseases. There fore, cardiovascular factors are well-known risk factors for ischemic stroke. We selected patients with ischemic stroke and with no evidence for arterial hypertension and carried out ACE polymorphism analysis. Association study of I/D polymorphism in group of these patients (52 individuals) and 80 control persons from the same population of Russian descent demonstrated no evidence for statistically significant differences in frequencies of I/D alleles or II/DD/ID genotypes between these groups. Thus, it suggests that ACE I/D polymorphism alone is not risk factor for stroke in non-hypertension patients. We cannot, however, exclude possible interaction between ACE-D/D genotype and sex.
Iu K
IuK
Moliaka
S V
SV
Petruk
S A
SA
Kir'ianov
A N
AN
Dzhibladze
A O
AO
Chechetkin
T V
TV
Shcherbatykh
E N
EN
Rogaev
D000328:Adult; D000368:Aged; D000483:Alleles; D001483:Base Sequence; D002545:Brain Ischemia / Q000235:genetics*; D005260:Female; D017353:Gene Deletion; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
D007703:Peptidyl-Dipeptidase A