PtdIns-3,4,5-P3: a regulatory nexus between tyrosine kinases and sustained calcium signals.
Scharenberg
A M
AM
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA.
Kinet
J P
JP
D002118:Calcium / Q000378:metabolism*; D007527:Isoenzymes / Q000378:metabolism*; D008954:Models, Biological; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism*; D000072183:Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; D051966:Phospholipase C gamma; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D015398:Signal Transduction; D010738:Type C Phospholipases / Q000378:metabolism*
D007527:Isoenzymes; D018129:Phosphatidylinositol Phosphates; C060974:phosphatidylinositol 3,4,5-triphosphate; C089848:Tec protein-tyrosine kinase; D011505:Protein-Tyrosine Kinases; D010744:Phosphoric Monoester Hydrolases; C098706:INPPL1 protein, human; D000072183:Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; D010738:Type C Phospholipases; D051966:Phospholipase C gamma; D002118:Calcium