Indole-2-carboxamide inhibitors of human liver glycogen phosphorylase.
Departments of Cardiovascular and Metabolic Diseases Medicinal Chemistry, Exploratory Medicinal Biology, and Cardiovascular and Metabolic Diseases Biology, Central Research Division, Pfizer Inc., Groton, Connecticut 06340, USA.
D J
DJ
Hoover
S
S
Lefkowitz-Snow
J L
JL
Burgess-Henry
W H
WH
Martin
S J
SJ
Armento
I A
IA
Stock
R K
RK
McPherson
P E
PE
Genereux
E M
EM
Gibbs
J L
JL
Treadway
D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002460:Cell Line; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000517:prevention & control; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006003:Glycogen / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007211:Indoles / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008099:Liver / Q000166:cytology / Q000201:enzymology* / Q000378:metabolism; D051379:Mice; D008820:Mice, Obese; D006005:Phosphorylases / Q000037:antagonists & inhibitors*; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D001786:Blood Glucose; D004791:Enzyme Inhibitors; D007004:Hypoglycemic Agents; D007211:Indoles; D011994:Recombinant Proteins; D006003:Glycogen; D006005:Phosphorylases