Iodixanol is readily eliminated by hemodialysis.
PURPOSE, MATERIAL AND METHODS, AND RESULTS: The dialyzability of the high-molecular X-ray contrast medium iodixanol was examined in an in vitro hemodialysis model using two different hollow fiber membranes: one high-flux (poly-sulfone) membrane and one intermediate-flux (cellulose triacetate) membrane. Blood flow was 200 ml/min and membrane area 1.3 m2. The dialyzer clearance of iodixanol dissolved in a mixture of leukocyte-filtered SAG-M blood and compatible citrate plasma was 134.2 +/- 3.6 ml/min for the polysulfone membrane and 113.0 +/- 3.6 ml/min for the cellulose triacetate membrane.


CONCLUSIONS
Iodixanol is readily dialyzed through commercial high-flux membranes.
Medical Department B, Oslo University Hospital (Rikshospitalet), Norway.
K J
KJ
Berg
B
B
Rolfsen
G
G
Stake
D002482:Cellulose / Q000031:analogs & derivatives; D003287:Contrast Media / Q000032:analysis / Q000302:isolation & purification*; D003404:Creatinine / Q000032:analysis; D005069:Evaluation Studies as Topic; D005374:Filtration / Q000295:instrumentation; D015312:Hemodialysis Solutions / Q000032:analysis; D006801:Humans; D066298:In Vitro Techniques; D008567:Membranes, Artificial; D011108:Polymers; D006435:Renal Dialysis / Q000295:instrumentation / Q000379:methods*; D013450:Sulfones; D014283:Triiodobenzoic Acids / Q000032:analysis / Q000302:isolation & purification*
D003287:Contrast Media; D015312:Hemodialysis Solutions; D008567:Membranes, Artificial; D011108:Polymers; D013450:Sulfones; D014283:Triiodobenzoic Acids; C017662:polysulfone P 1700; D002482:Cellulose; C024671:cellulose triacetate; D003404:Creatinine; C044834:iodixanol