Recent advances in the role of StAR.
It has been proposed that the steroidogenic acute regulatory (StAR) protein is the protein responsible for the acute regulation of steroid hormone biosynthesis. Virtually all of the observations made to date are consistent with this proposal. In this short review, background information leading to the discovery and characterization of the StAR protein and several recent and interesting observations concerning this protein are summarized.
Stocco
D M
DM
Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock 79430, USA.
D000595:Amino Acid Sequence; D000818:Animals; D057137:DAX-1 Orphan Nuclear Receptor; D004268:DNA-Binding Proteins / Q000502:physiology; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008969:Molecular Sequence Data; D010750:Phosphoproteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D018168:Receptors, Retinoic Acid / Q000502:physiology; D012097:Repressor Proteins; D014157:Transcription Factors / Q000502:physiology; D000098682:Steroidogenic Acute Regulatory Protein
D057137:DAX-1 Orphan Nuclear Receptor; D004268:DNA-Binding Proteins; C539965:NR0B1 protein, human; C539966:Nr0b1 protein, mouse; D010750:Phosphoproteins; D018168:Receptors, Retinoic Acid; D012097:Repressor Proteins; D014157:Transcription Factors; D000098682:Steroidogenic Acute Regulatory Protein