[A case of gastric cancer with decreased dihydropyrimidine dehydrogenase activity].
We analyzed the pyrimidine metabolite in the urine of a patient with severe mucositis and hand and foot syndrome, who was administered 5-fluorouracil for recurrence of gastric cancer. From our analysis, it was suggested that the patient had decreased dihydropyrimidine dehydrogenase activity. Dihydropyrimidine dehydrogenase activity is usually measured in peripheral blood mononuclear cells, but this time it was estimated from the analysis of uracil, dihydrouracil, thymine, and dihydrothymine in the urine. We concluded that urinary analysis of the pyrimidine metabolism is effective as screening for the prediction and prevention of 5-fluorouracil toxicity.
First Dept. of Surgery, Nagoya City University Medical School.
K
K
Kobayashi
S
S
Sumi
K
K
Kidouchi
I
I
Mizuno
N
N
Mohri
T
T
Fukui
Y
Y
Akamo
H
H
Takeyama
T
T
Manabe
D000230:Adenocarcinoma / Q000188:drug therapy / Q000201:enzymology*; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D042943:Dihydrouracil Dehydrogenase (NADP); D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D010088:Oxidoreductases / Q000378:metabolism*; D011743:Pyrimidines / Q000652:urine; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000201:enzymology*; D013941:Thymine / Q000652:urine; D014498:Uracil / Q000652:urine
D000964:Antimetabolites, Antineoplastic; D011743:Pyrimidines; D014498:Uracil; D010088:Oxidoreductases; D042943:Dihydrouracil Dehydrogenase (NADP); C030986:pyrimidine; D013941:Thymine; D005472:Fluorouracil