Molecular mechanisms of TNF receptor-mediated signaling.
Tumor necrosis factor alpha (TNF alpha) is a proinflammatory cytokine involved in a variety of physiological and pathological conditions. During the past several years substantial progress has been made toward a better understanding of how a single cytokine is able to exert obviously opposing effects (e.g., apoptosis and growth). This review focuses on the recently discovered TNF-receptor (TNFR)-associated proteins involved in the activation of intracellular signal-transduction cascades. It explains which classes of proteins have been described so far and how these factors are able to mediate different biological functions after TNFR activation.
Malek
N P
NP
Department of Gastroenterology and Hepatology, Medizinische Hochschule Hannover, Germany.
Pluempe
J
J
Kubicka
S
S
Manns
M P
MP
Trautwein
C
C
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D006801:Humans; D008024:Ligands; D008565:Membrane Proteins / Q000502:physiology*; D017434:Protein Structure, Tertiary; D018124:Receptors, Tumor Necrosis Factor / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D008024:Ligands; D008565:Membrane Proteins; D018124:Receptors, Tumor Necrosis Factor