Nicotine metabolism and intake in black and white smokers.
BACKGROUND
Racial differences in tobacco-related diseases are not fully explained by cigarette-smoking behavior. Despite smoking fewer cigarettes per day, blacks have higher levels of serum cotinine, the proximate metabolite of nicotine.


OBJECTIVE
To compare the rates of metabolism and the daily intake of nicotine in black smokers and white smokers.


METHODS
Participants received simultaneous infusions of deuterium-labeled nicotine and cotinine. Urine was collected for determination of total clearance of nicotine and cotinine, fractional conversion of nicotine to cotinine, and cotinine elimination rate. Using cotinine levels during ad libitum smoking and clearance data, the daily intake of nicotine from smoking was estimated.


METHODS
Metabolic ward of a university-affiliated public hospital.


METHODS
A total of 40 black and 39 white smokers, average consumption of 14 and 14.7 cigarettes per day, respectively, of similar age (mean, 32.5 and 32.3 years, respectively) and body weight (mean, 73.3 and 68.8 kg, respectively).


METHODS
Clearance (renal and nonrenal), half-life, and volume of distribution of nicotine and cotinine and the calculated daily intake of nicotine.


RESULTS
The total and nonrenal clearances of nicotine were not significantly different, respectively, in blacks (17.7 and 17.2 mL x min(-1) x kg(-1)) compared with whites (19.6 and 18.9 mL x min(-1) x kg(-1)) (P=.11 and .20). However, the total and nonrenal clearances of cotinine were significantly lower, respectively, in blacks (0.56 and 0.47 mL x min(-1) x kg(-1)) than in whites (0.68 vs 0.61 mL x min(-1) x kg(-1); P=.009 for each comparison). The nicotine intake per cigarette was 30% greater in blacks compared with whites (1.41 vs 1.09 mg per cigarette, respectively; P=.02). Volume of distribution did not differ for the 2 groups, but cotinine half-life was higher in blacks than in whites (1064 vs 950 minutes, respectively; P = .07).


CONCLUSIONS
Higher levels of cotinine per cigarette smoked by blacks compared with whites can be explained by both slower clearance of cotinine and higher intake of nicotine per cigarette in blacks. Greater nicotine and therefore greater tobacco smoke intake per cigarette could, in part, explain some of the ethnic differences in smoking-related disease risks.
Department of Medicine, Medical Effectiveness Research Center for Diverse Populations, San Francisco General Hospital Medical Center, CA, USA. eliseo_perez-stable@ucsfdgim.ucsf.edu
E J
EJ
Pérez-Stable
B
B
Herrera
P
P
Jacob
N L
NL
Benowitz
D000328:Adult; D019540:Area Under Curve; D044383:Black People; D002855:Chromatography, Thin Layer; D003367:Cotinine / Q000008:administration & dosage / Q000378:metabolism* / Q000493:pharmacokinetics; D003903:Deuterium / Q000008:administration & dosage; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007262:Infusions, Intravenous; D016014:Linear Models; D008297:Male; D009538:Nicotine / Q000008:administration & dosage / Q000378:metabolism* / Q000493:pharmacokinetics; D012907:Smoking / Q000208:ethnology* / Q000378:metabolism*; D044465:White People
D009538:Nicotine; D003903:Deuterium; D003367:Cotinine