Discovery of protease inhibitors using targeted libraries.
There continues to be considerable effort towards the construction of compound libraries targeted for the inhibition of protease enzymes. New tag-encoding methods for library deconvolution have been applied to this problem and there has been particular interest in novel solid-phase linkers for the introduction of key pharmacophore groups required for protease inhibition. Recent reports have tended to focus on nonpeptidic libraries, and, notably, structure-based design methods are now being applied to direct library design.
British Biotech Pharmaceuticals Ltd, Oxford, UK. whittaker@britbio.co.uk
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D002625:Chemistry, Organic / Q000379:methods*; D015195:Drug Design; D007202:Indicators and Reagents; D015394:Molecular Structure; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry; D010330:Patents as Topic; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry*
D007202:Indicators and Reagents; D009842:Oligopeptides; D011480:Protease Inhibitors