[The cytogenetic effect of cyclophosphane and the formation of active forms of oxygen in the bone marrow cells of C57Bl/6 and NZW mice].
Cytogenetic study conducted after a single intraperitoneal injection of cyclophosphane in doses of 10, 20, and 40 mg/kg showed in 1.5-2-month-old male mice that the level of bone marrow cells damaged by the mutagen was significantly higher in NZW animals than in C57Bl/6 animals. The ability to produce active oxygen forms in response to addition of opsonized zymosan and phorbol myristate acetate was also higher in bone marrow suspensions of NZW mice. The higher sensitivity of NZW animals to pro-oxidant and clastogenic effects may be related to the genetically determined decrease of antioxidant protection in NZW animals.
Guseva
N V
NV
Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
Durnev
A D
AD
Pleskovskaia
G N
GN
Seredenin
S B
SB
D000477:Alkylating Agents / Q000494:pharmacology*; D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D019069:Cell Respiration / Q000187:drug effects; D002869:Chromosome Aberrations; D003520:Cyclophosphamide / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005838:Genotype; D008163:Luminescent Measurements; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics* / Q000378:metabolism; D008814:Mice, Inbred NZB / Q000235:genetics* / Q000378:metabolism; D009153:Mutagens / Q000494:pharmacology*
D000477:Alkylating Agents; D009153:Mutagens; D003520:Cyclophosphamide