Suppression of cortical spreading depressions after magnesium treatment in the rat.
The aim of this study was to investigate whether the neuroprotective properties of magnesium in cerebral ischaemia involve suppression of repetitive tissue depolarizations. Cortical spreading depressions (CSDs), evoked by cortical KCl application, and cardiac arrest-induced anoxic depolarization (AD) were measured by extracellular DC recording on intact rat brain. At 90 min after onset of CSDs saline, MK-801 (3 mg/kg) or MgSO4 (90 mg/kg) was given i.v. Latency time to AD was measured after 4 h. The frequency of CSDs was significantly reduced in animals treated with MgSO4 or MK-801. AD was significantly delayed by MgSO4 but not by MK-801. Our results suggest that suppression of depolarization by magnesium may play a role in its neuroprotective properties in cerebral ischaemia.
Department of Neurosurgery, University Hospital Utrecht, The Netherlands.
W S
WS
van der Hel
W M
WM
van den Bergh
K
K
Nicolay
K A
KA
Tulleken
R M
RM
Dijkhuizen
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002491:Central Nervous System Agents / Q000008:administration & dosage / Q000494:pharmacology; D013181:Cortical Spreading Depression / Q000187:drug effects*; D016291:Dizocilpine Maleate / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D006323:Heart Arrest / Q000503:physiopathology; D002534:Hypoxia, Brain / Q000503:physiopathology; D007275:Injections, Intravenous; D008274:Magnesium / Q000008:administration & dosage / Q000494:pharmacology*; D008278:Magnesium Sulfate / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors
D002491:Central Nervous System Agents; D018691:Excitatory Amino Acid Antagonists; D018696:Neuroprotective Agents; D016194:Receptors, N-Methyl-D-Aspartate; D011189:Potassium Chloride; D016291:Dizocilpine Maleate; D008278:Magnesium Sulfate; D008274:Magnesium