Breast and lung cancers in two cyclosporin-A-treated psoriatic women.
We report malignant neoplasms of the breast and lung developed in two psoriatric patients after long-term treatment with low-dose cyclosporin A (CsA). A procarcinogen role of the drug cannot be ignored. Concern regarding the documented evidence from studies of organ transplant patients should be stressed in patients treated with low doses of CsA for chronic cutaneous inflammatory diseases.
Paquet
P
P
Department of Dermatopathology, University of Liège, Belgium.
Piérard
G E
GE
D000328:Adult; D001943:Breast Neoplasms / Q000209:etiology*; D016572:Cyclosporine / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008175:Lung Neoplasms / Q000209:etiology*; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy*
D007166:Immunosuppressive Agents; D016572:Cyclosporine