Signaling by Eph receptors and their ephrin ligands.
What are the mechanisms by which Eph receptor tyrosine kinases guide axons and migrating cells? Recent results show that Eph receptors bind some of the well-known effector molecules that are implicated in the organization of the actin cytoskeleton; moreover, biochemical and genetic evidence suggests a signaling role for transmembrane ephrin ligands in axon pathfinding.
European Molecular Biology Laboratory, Heidelberg, Germany. brueckne@embl-heidelberg.de
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D000818:Animals; D036383:Ephrin-A2; D036387:Ephrin-B1; D020690:GTPase-Activating Proteins; D008565:Membrane Proteins / Q000502:physiology*; D011506:Proteins / Q000502:physiology; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology*; D036183:Receptor, EphB2; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*; D019061:src-Family Kinases / Q000502:physiology
D036383:Ephrin-A2; D036387:Ephrin-B1; D020690:GTPase-Activating Proteins; D008565:Membrane Proteins; D011506:Proteins; D014157:Transcription Factors; D020794:Receptor Protein-Tyrosine Kinases; D036183:Receptor, EphB2; D019061:src-Family Kinases