Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome.
The SWI/SNF-related, matrix-associated, actin-dependent regulators of chromatin (SMARC), also called BRG1-associated factors, are components of human SWI/SNF-like chromatin-remodeling protein complexes. We mapped five human SMARC genes toregions on four different human chromosomes, SMARCC1 to 3p23-p21, SMARCC2 to 12q13-q14, SMARCD1 to 12q13-q14, SMARCD2 to 17q23-q24, and SMARCD3 to 7q35-q36. SMARCC1, SMARCC2, and SMARCD1 are assigned to chromosomal regions that are frequently involved in somatic rearrangements in human cancers. SMARCD1 was mapped to the critical region of Allgrove syndrome; however, no mutation was identified in one Allgrove syndrome family studied.
Department of Genetics, Stanford University School of Medicine, Stanford, California, 94305, USA.
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HZ
Ring
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Vameghi-Meyers
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Wang
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Crabtree
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Francke
D000015:Abnormalities, Multiple / Q000235:genetics; D002843:Chromatin / Q000378:metabolism; D002868:Chromosomal Proteins, Non-Histone; D002874:Chromosome Mapping; D002877:Chromosomes, Human / Q000235:genetics*; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics; D004268:DNA-Binding Proteins; D015321:Gene Rearrangement; D005819:Genetic Markers; D015894:Genome, Human; D006801:Humans; D009369:Neoplasms / Q000235:genetics; D013577:Syndrome; D014157:Transcription Factors / Q000235:genetics*
D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D005819:Genetic Markers; C101681:SMARCC1 protein, human; C101682:SMARCC2 protein, human; C109786:SMARCD1 protein, human; C491651:SMARCD2 protein, human; C491649:SMARCD3 protein, human; D014157:Transcription Factors