Macroangiopathy--does it play a role in young people?
Using a novel ultrasound method, brachial artery endothelial and smooth muscle physiology were studied in 20 adolescents with IDDM and in 20 nondiabetic subjects matched for age (13-22 years), gender and vessel size. Endothelium-dependent dilatation (EDD) was assessed in response to flow (EDD) and endothelium-independent vasodilatation after sublingual glyceryl trinitrate (GTN). Both EDD and GTN were reduced in those with IDDM compared with controls: 5 vs. 9%, (p = 0.0002) and 14 vs. 21% (p = 0.002). Abnormal EDD was found in 12 IDDM adolescents (diabetes duration 3.3-14.9 years). The mean urinary albumin excretion rate of the diabetic group with abnormal EDD was 5.76 +/- 2.82 vs. 8.05 +/- 4.88 microg/min in those with normal EDD (p = 0.25). In the diabetic adolescents there was no significant correlation observed between the test for early large vessel disease, HbAlc and tests for diabetic microangiopathy.
Donaghue
K C
KC
Ray Williams Institute of Paediatric Endocrinology, Diabetes and Metabolism, The Royal Alexandra Hospital for Children, Westmead, NSW, Australia. kimd@nch.edu.au
Robinson
J
J
McCredie
R
R
Fung
A
A
Silink
M
M
Celermajer
D S
DS
D000293:Adolescent; D000328:Adult; D000419:Albuminuria; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000503:physiopathology; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging / Q000503:physiopathology; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000000981:diagnostic imaging / Q000503:physiopathology; D005996:Nitroglycerin; D014463:Ultrasonography; D014664:Vasodilation
D006442:Glycated Hemoglobin; D005996:Nitroglycerin