Tachykinin-depolarizations mediated by neurokinin-3 receptors in the hamster submandibular ganglion cells.
In the majority of autonomic ganglia, the responses to tachykinins such as substance P, neurokinin A and neurokinin B are primarily mediated by neurokinin-3 (NK-3) receptors. Neurokinin B (NK-B) and senktide are known as an endogenous tachykinin and the related peptide selective for NK-3 receptor. In this study, the generation mechanism of NK-3 receptor agonist-induced response in the hamster submandibular ganglion (SMG) cells was investigated using the current-clamp technique. The SMG cells responded to the NK-3 receptor agonists with two types of depolarizations accompanied by either a decrease or an increase in membrane input resistance. The results showed that K+ channels alone or the combination of K+ and nonselective cation channels coupled with NK-3 receptors on the SMG cells were involved in generation of the NKB- and senktide-depolarizations.
Department of Physiology, Tokyo Dental College, Chiba, Japan.
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Yamada
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Endoh
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Suzuki
D000818:Animals; D006224:Cricetinae; D017097:Electric Impedance; D004594:Electrophysiology; D005726:Ganglia, Parasympathetic / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D007473:Ion Channels / Q000378:metabolism / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects; D015287:Neurokinin B / Q000494:pharmacology*; D018408:Patch-Clamp Techniques; D010446:Peptide Fragments / Q000494:pharmacology; D015221:Potassium Channels / Q000378:metabolism / Q000502:physiology; D018042:Receptors, Neurokinin-3 / Q000819:agonists / Q000378:metabolism / Q000502:physiology*; D013373:Substance P / Q000031:analogs & derivatives / Q000494:pharmacology; D015320:Tachykinins / Q000502:physiology
D007473:Ion Channels; D010446:Peptide Fragments; D015221:Potassium Channels; D018042:Receptors, Neurokinin-3; D015320:Tachykinins; C054724:senktide; D013373:Substance P; D015287:Neurokinin B