A chemo-enzymatic approach to the study of carbohydrate recognition in biological systems.
This report describes our recent work on the study of carbohydrate-mediated cell adhesion, including the development of new methods for carbohydrate synthesis, the inhibition of enzymes involved in the cell adhesion process and the design and synthesis of carbohydrate mimetics.
Department of Chemistry, Scripps Research Institute, La Jolla, CA 92037, USA.
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M
Hendrix
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Wong
D002448:Cell Adhesion / Q000502:physiology; D006020:Glycopeptides / Q000138:chemical synthesis*; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors; D016695:Glycosyltransferases / Q000037:antagonists & inhibitors; D006801:Humans; D007983:Lewis Blood Group Antigens; D016256:Lewis X Antigen / Q000737:chemistry*; D009844:Oligosaccharides / Q000138:chemical synthesis*; D000080506:Sialyl Lewis X Antigen
D006020:Glycopeptides; D007983:Lewis Blood Group Antigens; D016256:Lewis X Antigen; D009844:Oligosaccharides; D000080506:Sialyl Lewis X Antigen; D016695:Glycosyltransferases; D006026:Glycoside Hydrolases