[Genetic polymorphism of inter-alpha-trypsin inhibitor in six Chinese populations].
OBJECTIVE
To understand the distribution of allele frequencies of inter-alpha-trypsin inhibitor(ITI) in Chinese populations.


METHODS
The polymorphism of this protein in six Chinese populations was investigated using isoelectric focusing followed by immunoblotting technique.


RESULTS
Three common alleles, ITI*1, ITI*2, and ITI*3 were observed in four populations, namely Han living in Jilin, Mongol in Hailaer, Tibetan in Lasa, and Bai in Dali respectively. In other two populations, Zhuang in Guangxi and Han in Guangdong, only ITI*1 and ITI*2 were observed. For these populations, the frequency of ITI*1 ranges from 0.5500 to 0.7525; that of ITI*2 from 0.2475 to 0.4322; and that of ITI*3 from 0.0034 to 0.0729.


CONCLUSIONS
This study reveals that there is no parallel relationship between variation of allele frequencies and geographic differences.
Wu
J
J
Institute of Forensic Medicine, West China University of Medical Sciences, Chengdu, Sichuan, 610041 P. R. China. rechtsme@wcums.edu.cn
Hou
Y
Y
Li
Y
Y
Gou
Q
Q
Jin
Z
Z
Xu
Y
Y
D000510:Alpha-Globulins / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D002681:China; D005787:Gene Frequency; D005828:Genetics, Population; D006801:Humans; D011110:Polymorphism, Genetic; D014361:Trypsin Inhibitors / Q000235:genetics*
D000510:Alpha-Globulins; D014361:Trypsin Inhibitors; C011877:inter-alpha-inhibitor