In utero brain lesions in SIDS.
Serial examination of the cerebral hemispheres of 20 sudden infant death syndrome victims revealed high incidence of leukomalacia (40%), leptomeningeal glioneuronal heterotopias (70%) at the base of the cerebrum, and astrogliosis (65%) in the white matter and medulla reticular formation compared with 20 age-matched controls. These results suggest that an antepartum insult may become an important predisposing risk factor in some patients for sudden infant death syndrome.
Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.
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Obonai
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Takashima
D001921:Brain / Q000196:embryology / Q000473:pathology; D001927:Brain Diseases / Q000196:embryology / Q000473:pathology*; D002828:Choristoma / Q000196:embryology / Q000473:pathology*; D005260:Female; D005911:Gliosis / Q000196:embryology / Q000473:pathology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007969:Leukomalacia, Periventricular / Q000196:embryology / Q000473:pathology*; D008578:Meninges / Q000196:embryology / Q000473:pathology; D009457:Neuroglia; D009474:Neurons; D011247:Pregnancy; D012307:Risk Factors; D013398:Sudden Infant Death / Q000473:pathology*