Localization of neuropeptide Y Y1 receptor mRNA in human tooth pulp.
With immunocytochemistry numerous nerve fibres containing neuropeptide Y (NPY) were found in human molar pulp tissue, often around small blood vessels. Reverse transcriptase-polymerase chain reaction, using specific primers, detected mRNA of the human NPY Y1 receptor in the human pulp tissue. Thus, both NPY-containing nerve fibres and NPY Y1 receptor mRNA are present in human tooth pulp, possibly regulating vascular tone and pain perception.
Department of Oto-rhino-laryngology, Malmö General Hospital, Malmö, Sweden.
R
R
Uddman
J
J
Kato
L
L
Cantera
L
L
Edvinsson
D000328:Adult; D003782:Dental Pulp / Q000098:blood supply / Q000737:chemistry* / Q000294:innervation* / Q000378:metabolism; D004591:Electrophoresis, Polyacrylamide Gel; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D009478:Neuropeptide Y / Q000032:analysis*; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000032:analysis; D017476:Receptors, Neuropeptide Y / Q000032:analysis* / Q000096:biosynthesis*
D009478:Neuropeptide Y; D012333:RNA, Messenger; D017476:Receptors, Neuropeptide Y; C097212:neuropeptide Y-Y1 receptor