Soluble CD23 and IL-5 levels in the serum and culture supernatants of peripheral blood mononuclear cells in a girl with cutaneous paragonimiasis: case report.
We examined the levels of soluble CD23 (sCD23) and IL-5 in the serum and culture supernatants of the peripheral blood mononuclear cells of a 9-year-old girl with cutaneous paragonimiasis without respiratory symptoms. Before treatment, levels of both sCD23 and IL-5 in her serum and culture supernatants were elevated compared with those of controls. After successful treatment with praziquantel, sCD23 and IL-5 levels rapidly reduced to normal levels. These results indicate that sCD23 and IL-5 are involved in the immune-mediated pathological responses seen in paragonimiasis.
Department of Child Development, Kumamoto University School of Medicine, Japan.
T
T
Matsumoto
S
S
Kimura
M
M
Yamauchi
Y
Y
Nawa
T
T
Miike
D000977:Antiparasitic Agents; D000980:Antiplatyhelmintic Agents / Q000627:therapeutic use; D002478:Cells, Cultured; D002648:Child; D005260:Female; D006801:Humans; D015848:Interleukin-5 / Q000032:analysis*; D007963:Leukocytes, Mononuclear / Q000276:immunology; D010237:Paragonimiasis / Q000188:drug therapy / Q000276:immunology*; D011223:Praziquantel / Q000627:therapeutic use; D017455:Receptors, IgE / Q000097:blood*; D012876:Skin Diseases, Parasitic / Q000276:immunology*
D000977:Antiparasitic Agents; D000980:Antiplatyhelmintic Agents; D015848:Interleukin-5; D017455:Receptors, IgE; D011223:Praziquantel