Synthesis and antiviral activity of apio dideoxy nucleosides with azido or amino substituent.
Novel apio dideoxynucleosides with azido or amino or amino substituent were synthesized starting from 1,3-dihydroxyacetone utilizing an acid-catalyzed 1,4-conjugated addition as a key step and evaluated for antiviral activity. Unfortunately, they were found to be neither active against HIV-1, HSV-1,2 and poliovirus nor toxic.
Jeong
L K
LK
Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University, Seoul, Korea. lakjeong@mm.ewha.ac.kr
Lee
Y A
YA
Moon
H R
HR
Chun
M W
MW
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology*; D015224:Dideoxynucleosides / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology*
D000998:Antiviral Agents; D015224:Dideoxynucleosides