Evidence for sinoatrial blockade associated with high dose cytarabine therapy.
Cytarabine therapy is rarely complicated by cardiotoxicity. The present report describes the clinical course of a 35-year-old female patient with acute myelogenous leukemia in complete remission, who developed sinus bradycardia while on high dose cytarabine as a consolidation therapy. The electrocardiographic findings suggested that bradycardia was most probably the result of sinoatrial blockade. The available information regarding a possible association of cytarabine with disturbances of cardiac rhythm is reviewed.
Stamatopoulos
K
K
First Department of Medicine, University of Athens School of Medicine, Laikon General Hospital, Greece.
Kanellopoulou
G
G
Vaiopoulos
G
G
Stamatellos
G
G
Yataganas
X
X
D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D012848:Sinoatrial Block / Q000139:chemically induced* / Q000503:physiopathology
D000964:Antimetabolites, Antineoplastic; D003561:Cytarabine