Effect of iron deficiency anemia on lead distribution after intravenous dosing in rats.
OBJECTIVE
To determine the effect of iron deficiency anemia on blood and tissue lead distribution.


METHODS
24 weanling rats were divided into 2 groups. One group received an iron replete diet (200 ppm); the other received a low iron diet (20 ppm). After 24 days, each group was further subdivided into two doses of lead (5 mg/kg and 10 mg/kg) which was administered intravenously. Rats were continued on their respective diets for 7 days post-lead injection to allow tissue distribution, then sacrificed and blood and tissue lead concentration measured.


RESULTS
Prior to lead administration, baseline blood lead concentrations were not significantly different between groups. At sacrifice, whole blood lead levels were significantly higher in iron deficient animals than in iron replete at both 5 and 10 mg/kg administered lead. Iron deficient animals had comparable lead concentrations to iron replete animals in brain, kidney and liver. Femur lead concentrations were higher at 10 mg/kg administered lead.


CONCLUSIONS
Iron deficiency alters lead distribution such as that increased lead is found in blood for a given exposure.
Wright
R O
RO
Department of Medicine, Boston Children's Hospital, Massachusetts, USA. wright_r@a1.tch.harvard.edu
Hu
H
H
Maher
T J
TJ
Amarasiriwardena
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Chaiyakul
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Woolf
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Shannon
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MW
D018798:Anemia, Iron-Deficiency / Q000150:complications*; D000818:Animals; D004032:Diet; D004305:Dose-Response Relationship, Drug; D007262:Infusions, Intravenous; D007854:Lead / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution
D007854:Lead