GM1 activates the MAP kinase cascade through a novel wortmannin-sensitive step upstream from c-Raf.
Rampersaud
A A
AA
Ohio State University, Columbus 43210-1239, USA.
Van Brocklyn
J R
JR
Yates
A J
AJ
D000730:Androstadienes / Q000494:pharmacology; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000378:metabolism*; D004789:Enzyme Activation; D005677:G(M1) Ganglioside / Q000494:pharmacology*; D005910:Glioma; D006801:Humans; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology; D000081082:Phosphoinositide-3 Kinase Inhibitors; D019908:Proto-Oncogene Proteins c-raf / Q000378:metabolism*; D015398:Signal Transduction; D014407:Tumor Cells, Cultured; D000077191:Wortmannin
D000730:Androstadienes; D010726:Phosphodiesterase Inhibitors; D000081082:Phosphoinositide-3 Kinase Inhibitors; D005677:G(M1) Ganglioside; D019908:Proto-Oncogene Proteins c-raf; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D000077191:Wortmannin