Successful treatment of neonatal arterial thromboses with recombinant tissue plasminogen activator.
Seven newborns were treated with recombinant tissue plasminogen activator for arterial thromboses. Complete lysis occurred in four of seven and partial in two of seven patients. Serious bleeding complications were observed in two of seven patients. This and published experience suggest that successful lysis with recombinant tissue plasminogen activator occurs in most patients and that hemorrhagic complications are unusual but are not.
Department of Pediatrics, University of Michigan Medical School, Ann Arbor 48109-0254, USA.
G M
GM
Weiner
V P
VP
Castle
M A
MA
DiPietro
R G
RG
Faix
D001158:Arteries; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010960:Plasminogen Activators / Q000009:adverse effects / Q000627:therapeutic use*; D011994:Recombinant Proteins; D012189:Retrospective Studies; D012307:Risk Factors; D013927:Thrombosis / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000009:adverse effects / Q000627:therapeutic use*
D011994:Recombinant Proteins; D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator