Antispermatogenic and androgenic activities of Momordica charantia (Karela) in albino rats.
Petroleum ether, benzene and alcohol extracts of the seeds of Momordica charantia tested in rats at the dose level of 25 mg/100 g body weight for 35 days showed antispermatogenic activity as the number of spermatocytes, spermatids and spermatozoa was decreased. Increase in cholesterol level and Sudanophilic lipid accumulation indicates inhibition in the steroidogenesis. At the same time the weight of epididymis, prostate gland, seminal vesicle and levator ani was increased which showed its androgenic property. Out of the three extracts, the alcohol extract was more potent in its antispermatogenic, antisteroidogenic and androgenic activities.
Department of Zoology, Gulbarga University, India.
M Z
MZ
Naseem
S R
SR
Patil
S R
SR
Patil
Ravindra
R S
RS
Patil
D000473:Alkanes; D000728:Androgens / Q000494:pharmacology*; D000818:Animals; D000988:Antispermatogenic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001554:Benzene; D002784:Cholesterol / Q000032:analysis / Q000378:metabolism*; D004822:Epididymis / Q000187:drug effects; D000431:Ethanol; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use; D010946:Plants, Medicinal; D011467:Prostate / Q000187:drug effects; D051381:Rats; D012639:Seeds; D012669:Seminal Vesicles / Q000187:drug effects; D013076:Sperm Count; D013087:Spermatids / Q000187:drug effects; D013090:Spermatocytes / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects*
D000473:Alkanes; D000728:Androgens; D000988:Antispermatogenic Agents; D010936:Plant Extracts; D000431:Ethanol; D002784:Cholesterol; D001554:Benzene; C004544:naphtha