Changes in dendritic structure and function following hippocampal lesions: correlations with developmental events?
Recovery after nervous system lesions may lead to partial re-institution of developmental schemes and processes. Here we review several of these proposed schemes, with the conclusion that though some processes may involve re-expression of embryonic phenotypes, there are many processes invoked during recovery from lesions that do not mirror developmental phenomena. The inability to fully revert to embryonic schemes because of adult phenotype may partially account for the decreased recovery observed in adults compared to that noted after lesions during development.
Department of Anatomy & Cell Biology, Columbia University, College of Physicians & Surgeons, New York, NY 10032-3702, USA. jcb4@columbia.edu
J C
JC
Bulinski
T
T
Ohm
H
H
Roder
N
N
Spruston
D A
DA
Turner
H V
HV
Wheal
D000818:Animals; D003599:Cytoskeleton / Q000502:physiology / Q000648:ultrastructure; D003712:Dendrites / Q000502:physiology* / Q000648:ultrastructure; D005314:Embryonic and Fetal Development / Q000502:physiology; D006624:Hippocampus / Q000196:embryology / Q000502:physiology* / Q000648:ultrastructure; D006801:Humans; D019006:Neural Cell Adhesion Molecules / Q000096:biosynthesis; D009457:Neuroglia / Q000502:physiology; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology; D016704:Synapsins / Q000096:biosynthesis
D019006:Neural Cell Adhesion Molecules; D016704:Synapsins; D020794:Receptor Protein-Tyrosine Kinases