Regulation of phosphate transport in the renal tubule through parathyroid hormone receptor: unexpected pathways.
The recent molecular identification of parathyroid hormone (PTH) receptors, on the one hand, and Napi cotransporters, on the other hand, has enabled the development of powerful tools to boost the study of the regulation of renal Pi transport by PTH, a regulation which stands at a crucial point in the physiology and pathophysiology of Pi homeostasis. The aim of this review is to summarize these recent findings.
Department of Physiology, Faculté de Médecine Xavier-Bichat, Université Denis-Diderot, Paris, France.
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D000818:Animals; D001692:Biological Transport / Q000502:physiology; D002352:Carrier Proteins / Q000378:metabolism; D006801:Humans; D007684:Kidney Tubules / Q000378:metabolism*; D010281:Parathyroid Hormone / Q000502:physiology; D010710:Phosphates / Q000378:metabolism*; D018016:Receptors, Parathyroid Hormone / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D050608:Sodium-Phosphate Cotransporter Proteins; D027981:Symporters
D002352:Carrier Proteins; D010281:Parathyroid Hormone; D010710:Phosphates; D018016:Receptors, Parathyroid Hormone; D050608:Sodium-Phosphate Cotransporter Proteins; D027981:Symporters