Protein dynamics from NMR.
In the past several years a significant number of new multidimensional NMR methods have been developed to study molecular dynamics spanning a wide range of time scales. Applications involving a large number of biological systems have emerged and correlations with function established. Unique insights are obtained that are not available from structure alone, indicating the importance of dynamics studies for understanding function.
Kay
L E
LE
Protein Engineering Network Centers of Excellence and the Department of Medical Genetics, University of Toronto, Ontario, Canada. Kay@bloch.med.utoronto.ca
D001665:Binding Sites; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000502:physiology; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D011485:Protein Binding; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000502:physiology; D012996:Solutions; D013816:Thermodynamics
D004268:DNA-Binding Proteins; D011506:Proteins; D012996:Solutions