Role of jasmonic acid in biotransformation of (--)-isopiperitenone in suspension cell culture of Mentha piperita.
The role of jasmonic acid was studied in biotransformation of (--)-isopiperitenone to (--)-7-hydroxyisopiperitenone using alpha suspension cells were treated with (--)-isopiperitenone, mRNA of a cytochrome P450 was induced in a similar time-course pattern as the biotransformation shown in a previous study (Park et al., 1997). The induction of P450 mRNA and the biotransformation of (--)-isopiperitenone were increased by methyl jasmonate, but decreased by salicylhydroxamic acid, and inhibitor of jasmonic acid synthesis. These results suggest that the biotransformation involves the induction of P450 which is mediated by jasmonic acid as a signaling molecule.
Son
J S
JS
Department of Agricultural Chemistry, College of Agriculture and Life Sciences, Seoul National University, Suwon, Korea.
Chang
Y J
YJ
Choi
Y D
YD
Kim
S U
SU
D000085:Acetates / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D001711:Biotransformation / Q000187:drug effects; D002457:Cell Extracts / Q000737:chemistry / Q000494:pharmacology; D002473:Cell Wall / Q000737:chemistry; D002478:Cells, Cultured; D003517:Cyclopentanes / Q000494:pharmacology*; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects / Q000235:genetics; D005786:Gene Expression Regulation / Q000187:drug effects; D039821:Monoterpenes; D054883:Oxylipins; D059828:Plant Cells; D010937:Plant Growth Regulators / Q000494:pharmacology*; D010944:Plants / Q000187:drug effects* / Q000378:metabolism*; D012333:RNA, Messenger / Q000187:drug effects / Q000235:genetics; D012457:Salicylamides / Q000494:pharmacology; D013729:Terpenes / Q000378:metabolism / Q000493:pharmacokinetics*; D015003:Yeasts / Q000737:chemistry
C114496:7-hydroxyisopiperitenone; D000085:Acetates; D000935:Antifungal Agents; D002457:Cell Extracts; D003517:Cyclopentanes; D065607:Cytochrome P-450 Enzyme Inhibitors; D039821:Monoterpenes; D054883:Oxylipins; D010937:Plant Growth Regulators; D012333:RNA, Messenger; D012457:Salicylamides; D013729:Terpenes; C044944:isopiperitenone; C011006:jasmonic acid; C005703:salicylhydroxamic acid; C072239:methyl jasmonate; D003577:Cytochrome P-450 Enzyme System