Characterisation of a collecting duct carcinoma by cytogenetic analysis and comparative genomic hybridisation.
Collecting duct carcinoma (CDC) is a rare variant of carcinoma of the kidney with aggressive behaviour. CDC arise from the epithelium of the ducts of Bellini in the distal nephron. A CDC in a 53-year old male patient is characterised both by cytogenetic analysis and comparative genomic hybridisation (CGH). The cytogenetic analysis shows a biclonal karyotype 47,XY,+3[2]/40-44,XY,-12[3], -22[4][cp5]/46,XY[42]. Loss of DNA sequences detected by CGH involves chromosome 1, 2, 9, 11 and 18. Gain of DNA sequences affect chromosome 16 and 20. The characterisation of a CDC in this study represents an additional contribution to the poorly explored CDC.
Institut fur Medizinische Biologie und Humangenetik der Universitat Innsbruck, A-6020 Innsbruck, Austria.
I
I
Verdorfer
Z
Z
Culig
A
A
Hobisch
G
G
Bartsch
A
A
Hittmair
H C
HC
Duba
M
M
Erdel
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D007680:Kidney Neoplasms / Q000235:genetics*; D007685:Kidney Tubules, Collecting; D008297:Male; D008875:Middle Aged