Synthetic study on a novel Asn-linked core structure: synthesis of a pentasaccharide alpha-D-Man-(1-->3)-[alpha-D-Man-(1-->6)]-beta-D-Man-(1-->4)- [beta-D-GlcNAc-(1-->60]-beta-D-GlcNAc-->OMp.
Synthesis of a pentasaccharide alpha-D-Man-(1-->3)-[alpha-D-Man-(1-->6)] -beta-D-Man-(1-->4)-beta-D-GlcNac(1-->6)]beta-GlcNAc-->Omp (2) is described. A comparison between the 1H NMR data of 2 and those of a novel Asn-linked core structure 1 containing a new GlcNAc residue suggests an alpha-D-configuration for the new linkage.
Institute of Physical and Chemical Research (RIKEN), Saitama, Japan.
Z W
ZW
Guo
Y
Y
Ito
Y
Y
Nakahara
T
T
Ogawa
D000117:Acetylglucosamine / Q000737:chemistry; D002240:Carbohydrate Sequence; D006023:Glycoproteins / Q000737:chemistry; D007536:Isomerism; D008969:Molecular Sequence Data; D019906:Nuclear Magnetic Resonance, Biomolecular; D009844:Oligosaccharides / Q000138:chemical synthesis*
D006023:Glycoproteins; D009844:Oligosaccharides; D000117:Acetylglucosamine