[Mechanism of Enterovirus participation in epidemic neuropathy. Physiopathological hypothesis].
During the epidemic neuropathy occurred in Cuba from 1992 to 1993, viral isolations antigenically connected with Coxsackie viruses were obtained from the cerebrospinal fluid of patients. Virological, epidemiological, toxicologic, nutritional, immunological and histopathological investigations were made. Though the disease was related to toxic and nutritional factors, it has been impossible to identify the cause of the epidemic. Taking into consideration the results of the different investigations, we have formulated a comprehensive and multifactorial hypothesis to explain the physiopathological mechanism of the participation of the isolated viruses as mediators in a process of autoimmunity of the pathogeny of the disease.
Instituto de Medicina Tropical Pedro Kourí, Ciudad de La Habana, Cuba.
P
P
Más Lago
M G
MG
Guzmán
L
L
Sarmiento
A B
AB
Pérez
M
M
Alvarez
V
V
Capó
G
G
Kourí
D000818:Animals; D001327:Autoimmune Diseases / Q000134:cerebrospinal fluid / Q000453:epidemiology / Q000209:etiology* / Q000276:immunology / Q000821:virology; D002555:Cerebrospinal Fluid / Q000821:virology; D003384:Coxsackievirus Infections / Q000150:complications* / Q000453:epidemiology / Q000276:immunology; D003462:Cuba / Q000453:epidemiology; D003588:Cytopathogenic Effect, Viral; D004196:Disease Outbreaks; D004770:Enterovirus / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity* / Q000502:physiology; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis; D051379:Mice; D008954:Models, Biological; D018716:Molecular Mimicry; D009419:Nerve Tissue Proteins / Q000276:immunology; D009748:Nutrition Disorders / Q000150:complications; D009901:Optic Nerve Diseases / Q000134:cerebrospinal fluid / Q000453:epidemiology / Q000209:etiology* / Q000276:immunology / Q000821:virology; D010523:Peripheral Nervous System Diseases / Q000134:cerebrospinal fluid / Q000453:epidemiology / Q000209:etiology* / Q000276:immunology / Q000821:virology; D012907:Smoking / Q000009:adverse effects; D016176:T-Lymphocyte Subsets / Q000276:immunology; D014764:Viral Proteins / Q000276:immunology; D017735:Virus Latency
D007376:Interleukin-2; D009419:Nerve Tissue Proteins; C089732:P2-C protein, Coxsackievirus; D014764:Viral Proteins