Serum and bile interleukin 6 after percutaneous transhepatic cholangio-drainage.
OBJECTIVE
This study was designed to assess the correlation of interleukin 6 (IL-6) with jaundice reduction by percutaneous transhepatic cholangio-drainage (PTCD) for obstructive jaundice.


METHODS
We measured serum and bile IL-6 concentrations by enzyme linked immuno-sorbent assay before and after PTCD in 26 patients with obstructive jaundice. The patients were divided into two groups according to their bilirubin decrease rate.


RESULTS
Serum IL-6 levels measured before and after PTCD in the slowly decreasing bilirubin group ("poor" group) were significantly higher than those of the rapidly decreasing bilirubin group ("good" group). Measures of bile IL-6 in the "poor" group remained high from 3 to 14 days after PTCD in comparison with the "good" group.


CONCLUSIONS
These results suggest that circulating IL-6, as well as IL-6 in the bile, may be involved in the pathogenesis of obstructive jaundice, and play an important role in preventing the resolution of obstructive jaundice after PTCD.
Akiyama
T
T
Dept. of General and Digestive Surgery, Kanazawa Medical University, Ishikawa, Japan.
Hasegawa
T
T
Sejima
T
T
Sahara
H
H
Seto
K
K
Saito
H
H
Takashima
S
S
D000368:Aged; D001646:Bile / Q000737:chemistry*; D001660:Biliary Tract Diseases / Q000276:immunology; D002779:Cholestasis / Q000276:immunology* / Q000601:surgery; D004322:Drainage; D004724:Endoscopy; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000032:analysis* / Q000097:blood; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged
D015850:Interleukin-6