Cases of systemic immediate-type urticaria associated with acellular diphtheria-tetanus-pertussis vaccination.
The authors found eight children who had systemic urticaria within 30 min after administration of acellular diphtheria-tetanus-pertussis (DTP) vaccines which contain gelatin as a stabilizer. The authors measured the specific IgE to gelatin and DTP toxoids in their sera, and found that none of the children had anti-gelatin IgE. Of the eight children, two had detectable levels of anti-toxoid IgE. As a negative control, of the 10 children who showed no allergic reaction to the acellular DTP vaccines, four also had detectable levels of anti-toxoid IgE. From these results, there was no obvious relationship between the specific IgE to the vaccine's component proteins and systemic urticaria to acellular DTP vaccines.
Department of Immunology, National Institute of Infectious Diseases, Tokyo, Japan.
M
M
Sakaguchi
T
T
Nakayama
S
S
Inouye
D001426:Bacterial Proteins / Q000009:adverse effects*; D002675:Child, Preschool; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000009:adverse effects*; D005260:Female; D005780:Gelatin / Q000009:adverse effects*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology*; D007073:Immunoglobulin E / Q000097:blood; D007223:Infant; D008297:Male; D012135:Respiratory Sounds; D014121:Toxoids / Q000009:adverse effects*; D014581:Urticaria / Q000276:immunology*
D001426:Bacterial Proteins; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D014121:Toxoids; D007073:Immunoglobulin E; D005780:Gelatin