The mycobacterial cell wall: structure, biosynthesis and sites of drug action.
Structural analysis has been successfully implemented recently to obtain valuable information on the mycobacterial cell wall components, many of which have formed the basis for biosynthesis and functional studies towards developing better drugs and possible vaccines. The highly complex and well organized structure unique to mycobacteria, represents the best target for novel antimycobacterial agents. Until recently, our knowledge of the enzymes responsible for the biogenesis of the cell wall components was almost negligible. The pathways are now being elucidated in several laboratories. Highlights of this review include significant advances in the structure and biochemistry of the major cell wall components and potential targets for generation of new drugs.
Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523, USA. delphi@lamar.colostate.edu
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D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D002473:Cell Wall / Q000737:chemistry* / Q000648:ultrastructure; D005685:Galactans / Q000737:chemistry; D006801:Humans; D008070:Lipopolysaccharides / Q000737:chemistry; D008969:Molecular Sequence Data; D009161:Mycobacterium / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism*; D009164:Mycobacterium Infections / Q000188:drug therapy; D009171:Mycolic Acids / Q000737:chemistry; D010457:Peptidoglycan / Q000737:chemistry
D000900:Anti-Bacterial Agents; D005685:Galactans; D008070:Lipopolysaccharides; D009171:Mycolic Acids; D010457:Peptidoglycan; C050016:lipoarabinomannan; C005653:arabinogalactan