A modulatory effect of extracellular Ca2+ on type 1alpha metabotropic glutamate receptor-mediated signalling.
Increasing [Ca2+]e from 1.3 4 mM had little effect on basal phospholipase C activity in baby hamster kidney (BHK) cells stably expressing either type 1alpha metabotropic glutamate (mGlu1alpha) or M3-muscarinic (m3) receptors, but enhanced agonist-stimulated phosphoinositide hydrolysis in BHK-mGlu1alpha, but not BHK-m3 cells, demonstrating that Ca2+(e) selectively modulates phosphoinositide signalling stimulated by this receptor subtype.
Department of Cell Physiology and Pharmacology, University of Leicester, UK.
R
R
Saunders
S R
SR
Nahorski
R A
RA
Challiss
D000818:Animals; D001115:Arecoline / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology*; D002460:Cell Line; D006224:Cricetinae; D003515:Cycloleucine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004789:Enzyme Activation; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology*; D007295:Inositol Phosphates / Q000096:biosynthesis*; D007668:Kidney / Q000187:drug effects / Q000502:physiology; D016210:Methacholine Chloride / Q000494:pharmacology; D018721:Muscarinic Agonists / Q000494:pharmacology; D016318:Quisqualic Acid / Q000494:pharmacology*; D018094:Receptors, Metabotropic Glutamate / Q000187:drug effects / Q000502:physiology*; D011976:Receptors, Muscarinic / Q000187:drug effects; D010738:Type C Phospholipases / Q000378:metabolism
D018690:Excitatory Amino Acid Agonists; D007295:Inositol Phosphates; D018721:Muscarinic Agonists; D018094:Receptors, Metabotropic Glutamate; D011976:Receptors, Muscarinic; C104077:metabotropic glutamate receptor type 1; D003515:Cycloleucine; D016210:Methacholine Chloride; C036361:1-amino-1,3-dicarboxycyclopentane; D001115:Arecoline; D016318:Quisqualic Acid; D010738:Type C Phospholipases; D002118:Calcium