Efficacy of oral fluconazole in tinea pedis of the hyperkeratotic type. Stratum corneum levels.
In this study, in addition to studying the efficacy and safety of the once-daily administration of 100-mg capsules of fluconazole over an 8-week administration period with six patients with hyperkeratotic-type tinea pedis, we also measured the serum and horny layer concentrations of fluconazole to study the mobility into the horny layer in diseased areas of the sole skin. The final overall efficacy and overall safety were both 100% (six out of six), and no side-effects, including abnormal laboratory changes, were observed in any of the patients. The drug mobility study revealed that in the horny layer of the skin a steady state was reached after 4 weeks of administration, with the mean concentration being 12.8 micrograms g-1. This concentration was a high concentration that was no less than 13 times the geometric mean MIC (0.972 microgram ml-1) for fresh clinical isolates of Trichophyton rubrum. Based on the above results, fluconazole is considered to be highly useful for treating various kinds of dermatomycosis, including hyperkeratotic-type tinea pedis.
Department of Dermatology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
H
H
Tanuma
M
M
Doi
A
A
Yaguchi
Y
Y
Ohta
S
S
Nishiyama
K
K
Sekiguchi
K
K
Katsuoka
D000284:Administration, Oral; D000328:Adult; D000935:Antifungal Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005260:Female; D015725:Fluconazole / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D007642:Keratosis / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000378:metabolism*; D014008:Tinea Pedis / Q000145:classification / Q000188:drug therapy*
D000935:Antifungal Agents; D015725:Fluconazole