Comparison of three composite compliance indices in a trial of self-administered preventive therapy for tuberculosis in HIV-infected Ugandan adults. Uganda-Case Western Reserve University Research Collaboration.
Compliance with tuberculosis preventive therapy in a randomized placebo-controlled trial in 2736 HIV-infected Ugandans was measured using urinary isoniazid metabolite testing, clinic attendance, and self-report. Overall, 77% of urine tests were positive, subjects kept 85% of their scheduled visits while on therapy, and 69% reportedly never forgot to take their medication. Different strategies were used for constructing three composite compliance indices in active arms: (1) an unweighted index of the summed scores on scaled compliance measures; (2) a weighted index using weights obtained from a survey of experts on tuberculosis; and (3) a statistically weighted index using principal components analysis. Composite indices were evaluated for reliability, validity, and practical utility. Understanding of the regimen, study arm, subsequent follow-up, tuberculosis status, and urine spot-check result were associated with composite compliance scores. The unweighted index in this study performed as well as the weighted indices.
Department of Medicine, Case Western Reserve University and University Hospitals of Cleveland, Ohio 44106-4984, USA.
V
V
Pekovic
H
H
Mayanja
M
M
Vjecha
J
J
Johnson
A
A
Okwera
P
P
Nsubuga
R
R
Mugerwa
J
J
Ellner
C
C
Whalen
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy* / Q000652:urine*; D000328:Adult; D000553:Ambulatory Care / Q000706:statistics & numerical data*; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000652:urine*; D008297:Male; D010349:Patient Compliance; D016032:Randomized Controlled Trials as Topic; D015203:Reproducibility of Results; D012646:Self Administration / Q000592:standards*; D011795:Surveys and Questionnaires / Q000592:standards*; D014376:Tuberculosis / Q000188:drug therapy* / Q000652:urine*; D014454:Uganda
D007538:Isoniazid