Suppression of ovarian oxytocin secretion after intra-luteal administration of the arachidonate 5-lipoxygenase inhibitor BWA4C in the ewe.
The effect of an intra-luteal injection of the 5-lipoxygenase (5-LO) inhibitor BWA4C (2 mg in 50 microl DMSO) on the secretion of oxytocin (OT) from the corpus luteum in response to a close-arterial infusion of prostaglandin (PG)-F2alpha (5 ng min(-1)) was examined in anaesthetised sheep. Within 30 minutes of administration both basal (pre-infusion) and PGF2alpha-stimulated OT release into the posterior vena cava were significantly (P<0.01) reduced. These results are consistent with the proposition that 5-LO products of arachidonic acid may modulate OT secretion from the ovine corpus luteum.
Department of Veterinary Preclinical Sciences, University of Liverpool, South Wirral, Cheshire.
R G
RG
Cooke
N
N
Ahmad
T
T
Nicholson
D000818:Animals; D044482:Benzeneacetamides; D003338:Corpus Luteum / Q000187:drug effects* / Q000502:physiology; D015237:Dinoprost / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006877:Hydroxamic Acids / Q000494:pharmacology*; D007261:Infusions, Intra-Arterial; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology*; D010053:Ovary / Q000187:drug effects / Q000378:metabolism*; D010121:Oxytocin / Q000097:blood / Q000378:metabolism*; D012756:Sheep; D013997:Time Factors; D014682:Vena Cava, Inferior
D044482:Benzeneacetamides; D006877:Hydroxamic Acids; D016859:Lipoxygenase Inhibitors; C056614:N-(3-phenoxycinnamyl)acetohydroxamic acid; D010121:Oxytocin; D015237:Dinoprost