[Changes in calcium homeostasis in the development of diabetes mellitus].
The review analyzes the mechanisms of hormonal regulation of the exchange of Ca ions in the organisms and the role of changes in their extra- and intracellular balance in the development of diabetes mellitus. Recent data about changes in intracellular Ca homeostasis which lead to alterations in insulin secretion are presented. A conclusion is made about tight connections of disturbances in hormonal and calcium homeostasis in the pathogenesis of diabetes and its complications.
Kostiuk
Ie P
IeP
Institute of Endocrinology and Metabolism, Academy of Medical Sciences, Kiev, Ukraine.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000209:etiology / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000209:etiology / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D014807:Vitamin D / Q000378:metabolism
D007328:Insulin; D014807:Vitamin D; D002118:Calcium