Accessory factor-bZIP-DNA interactions.
DNA binding and transcriptional activation by basic region leucine zipper (bZIP) proteins can be enhanced by accessory factors. In the past year, three accessory factor-bZIP-DNA complexes have been investigated extensively. Experiments have probed the effect of accessory factors on bZIP-DNA specificity, the residues that participate in stabilizing these complexes, the contribution of DNA conformation to accessory factor-bZIP interactions, and the relative stabilization of bZIP dimerization and DNA binding by accessory factors.
Department of Chemistry, Wesleyan University, Middletown, CT 06459, USA. abaranger@mail.wesleyan.edu
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D018736:DNA Adducts / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D006515:Hepatitis B virus / Q000378:metabolism*; D015368:Human T-lymphotropic virus 1 / Q000378:metabolism*; D006801:Humans; D016350:Leucine Zippers; D050778:NFATC Transcription Factors; D009687:Nuclear Proteins; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic
D018736:DNA Adducts; D004268:DNA-Binding Proteins; D050778:NFATC Transcription Factors; D009687:Nuclear Proteins; D014157:Transcription Factors