Effect of black tea polyphenols on plasma lipids in cholesterol-fed rats.
The influence of black tea polyphenols on plasma lipid levels was investigated in rats fed a 15% lard and 1% cholesterol diet. The diet was supplemented with 1% black tea polyphenols extracted and condensed from black tea. Rats fed the lard-cholesterol diet showed an increase in plasma cholesterol and liver lipids compared to rats fed a basal diet. The supplementation of black tea polyphenols in this lard-cholesterol diet decreased the lipid levels in the plasma and increased the fecal excretion of total lipids and cholesterol. On the other hands, 1% supplementation of either instant black tea with a 20% polyphenol content of 0.2% supplementation of EGCg in the lard-cholesterol diet had no effect on plasma cholesterol and phospholipid levels. These results suggest that a high dose of black tea polyphenols exerts a hypocholesterolemic effect in cholesterol-fed rats.
Food Research Laboratories, Mitsui Norin Co., Ltd., Shizuoka, Japan.
N
N
Matsumoto
K
K
Okushio
Y
Y
Hara
D000818:Animals; D000924:Anticholesteremic Agents; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D004041:Dietary Fats / Q000008:administration & dosage; D005419:Flavonoids; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000033:anatomy & histology / Q000378:metabolism; D008297:Male; D009929:Organ Size; D010636:Phenols / Q000494:pharmacology*; D010743:Phospholipids / Q000097:blood; D011108:Polymers / Q000494:pharmacology*; D059808:Polyphenols; D051381:Rats; D017208:Rats, Wistar; D013662:Tea / Q000737:chemistry*; D014280:Triglycerides / Q000378:metabolism
D000924:Anticholesteremic Agents; D002791:Cholesterol, Dietary; D004041:Dietary Fats; D005419:Flavonoids; D008055:Lipids; D010636:Phenols; D010743:Phospholipids; D011108:Polymers; D059808:Polyphenols; D013662:Tea; D014280:Triglycerides; D002784:Cholesterol; C029310:lard