Slowed information processing in HIV-1 disease. The Multicenter AIDS Cohort Study (MACS).
This investigation examined the effects of HIV-1 infection on speeded complex cognitive processing in a group of HIV-negative (n = 666), HIV-positive symptomatic (n = 156), and HIV-positive asymptomatic (n = 623) participants while controlling for the effects of slowed motor functioning, peripheral neuropathy, and several other putative confounds. Stroop Interference and reaction-time tasks served as anchor procedures to assess cognitive processing. The present findings suggest that HIV-1 infection is capable of compromising CNS-mediated cognitive processes (speeded processing) infringing upon their efficacy in the symptomatic stages of the disease while sparing individuals in the asymptomatic stage. The detrimental effects observed on information-processing mechanisms associated with HIV infection persisted despite the use of procedures to control for peripheral nerve integrity and other potential confounds.
Department of Psychiatry and Biobehavioral Sciences, University of California School of Medicine, Los Angeles, CA, USA.
A M
AM
Llorente
E N
EN
Miller
L F
LF
D'Elia
O A
OA
Selnes
J
J
Wesch
J T
JT
Becker
P
P
Satz
D015526:AIDS Dementia Complex / Q000175:diagnosis* / Q000523:psychology; D000328:Adult; D001288:Attention; D015331:Cohort Studies; D003118:Color Perception; D004193:Discrimination Learning; D015497:HIV-1; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011340:Problem Solving; D011930:Reaction Time; D012660:Semantics