The role of endothelin in hypertension.
The endothelins are 21-amino-acid peptides which may play a role in the pathogenesis of hypertension. There is increasing evidence that the endothelins have a central function in mediating end-organ damage in hypertension, and that important effects of endothelin in the pathogenesis of hypertension may be based on the interactions of the endothelins and the renin-angiotensin and the nitric oxide systems.
Rothermund
L
L
Department of Clinical Pharmacology and Toxicology, Freie Universität Berlin, Germany.
Paul
M
M
D000818:Animals; D004195:Disease Models, Animal; D065128:Endothelin Receptor Antagonists; D016232:Endothelins / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000503:physiopathology*; D017466:Receptors, Endothelin / Q000502:physiology
D065128:Endothelin Receptor Antagonists; D016232:Endothelins; D017466:Receptors, Endothelin