Combinatorial libraries of transition-metal complexes, catalysts and materials.
The design, synthesis and evaluation of transition metal containing combinatorial libraries has received much attention in the past few years. As a result, a variety of synthetic techniques have been developed, and rapid assays for metal ion binding have yielded new ligand classes displaying high affinity and selectivity. Research in catalysis has centered around lead optimization using much smaller parallel libraries because of the lack of a truly efficient reaction screening method. Materials science applications have also focused on spatially addressed libraries and have employed a variety of techniques to identify compounds with desired physical properties. Nonetheless, high-throughput characterization and reaction product detection methods must still be developed in order to realize the full potential of combinatorial chemistry for the discovery of novel metal-containing compounds.
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
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Francis
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Jamison
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Jacobsen
D001665:Binding Sites; D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D015195:Drug Design; D008024:Ligands; D008670:Metals; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry*; D019151:Peptide Library
D008024:Ligands; D008670:Metals; D009842:Oligopeptides; D019151:Peptide Library