Increased caveolin-3 levels in mdx mouse muscles.
The density of skeletal muscle caveolae is increased in Duchenne muscular dystrophy and its genetic homologue, the mdx mouse. This structural change is significant as it may indicate muscle regeneration. We identified in mdx mouse tibialis anterior muscles significantly increased levels of caveolin-3, the chief protein in muscle caveolae, and reduced levels of neuronal nitric oxide synthase, an enzyme regulated by caveolin-3. Similar changes occurred in the corresponding mRNA levels. These data suggest that induction of caveolin-3 occurs and this may at least partly be responsible for increased number of caveolae, altered nNOS-caveolin cycle, and regeneration of dystrophic muscles.
Department of Medical Biochemistry, College of Medicine, The Ohio State University, Columbus 43210, USA. vaghy.1@osu.edu
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D000818:Animals; D015153:Blotting, Western; D051244:Caveolin 3; D022461:Caveolins; D008565:Membrane Proteins / Q000378:metabolism*; D051379:Mice; D018101:Mice, Inbred mdx; D009124:Muscle Proteins / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism*; D009137:Muscular Dystrophy, Animal / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000378:metabolism
C495548:Cav3 protein, mouse; D051244:Caveolin 3; D022461:Caveolins; D008565:Membrane Proteins; D009124:Muscle Proteins; D019001:Nitric Oxide Synthase