Aging and cerebrovascular disease.
Aging influences cerebrovascular disease expression by a variety of mechanisms. Age-related changes in cerebral autoregulation, cellular metabolism, the blood-brain barrier, and autonomic function may leave the cerebrovascular system vulnerable to injury. Certain cerebrovascular disease, such as atrial fibrillation, watershed infarctions, carotid artery atherosclerosis, cerebral hemorrhages, subdural hematomas, and transient global amnesia manifest in the elderly. Vascular dementia and white matter disease are better understood with newer neuroimaging studies, careful neuropsychological and histopathologic examinations. Atherosclerosis and cerebral amyloid angiopathy may have larger roles than previously understood in Alzheimer's disease.
Department of Neurology, Barnes-Jewish Hospital, Washington University, St. Louis, Missouri 63110-1093, USA.
J Y
JY
Choi
J C
JC
Morris
C Y
CY
Hsu
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001281:Atrial Fibrillation / Q000150:complications; D001812:Blood-Brain Barrier / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000502:physiology; D002561:Cerebrovascular Disorders / Q000150:complications / Q000175:diagnosis*; D006706:Homeostasis; D006801:Humans; D019636:Neurodegenerative Diseases / Q000150:complications