Reduction of reperfusion injury edema with corticotropin-releasing factor (CRF): a pilot study.
Regulation of capillary permeability with ischemic reperfusion injury is a complex interaction between vascular endothelium and circulating blood factors. Corticotropin-releasing factor (CRF), a 41 -amino acid peptide CNS neurotransmitter known to modulate the pituitary-adrenal axis during stress response, has been shown to affect capillary leakage after thermal injury in peripheral tissue. When administered prior to ischemic reperfusion injury in a pedicled rat hindlimb model, CRF (80 mcg/kg) reduced limb weight gain to approximately 50% of saline control, suggesting a role for CRF in control of vascular permeability. The characteristics of CRF are reviewed.
Division of Plastic and Reconstructive Surgery, Lahey Hitchcock Clinic, Burlington, MA 01805, USA.
T M
TM
Whitney
M L
ML
Bentz
P C
PC
Johnson
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004487:Edema / Q000517:prevention & control*; D005260:Female; D006614:Hindlimb / Q000098:blood supply / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D010865:Pilot Projects; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D015427:Reperfusion Injury / Q000517:prevention & control*; D012965:Sodium Chloride / Q000494:pharmacology
D012965:Sodium Chloride; D003346:Corticotropin-Releasing Hormone