Comparison of oral and intravenous routes of giving tenoxicam.
Twenty-five fit patients undergoing third molar surgery received the non-steroidal anti-inflammatory drug tenoxicam 40 mg given orally the night before surgery or intravenously at the time of surgery in a randomised, double-blind, cross-over trial. Propofol was used for intravenous sedation. Pain on injection was noted with propofol in 32-56 percent of subjects, but was mostly of minor nature. There was high (100 percent) acceptance of the method of sedation, with 60-84 percent rate of amnesia. Experience of post-operative pain, intake of medication, and trismus were similar with both methods of administration of tenoxicam. We conclude that both oral and intravenous administration of 40 mg tenoxicam are equally effective in healthy young patients undergoing third molar surgery.
Department of Stomatology, School of Dentistry, University of Otago, Dunedin.
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D000284:Administration, Oral; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D016292:Procedural Sedation; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use; D007275:Injections, Intravenous; D007430:Intraoperative Care; D008297:Male; D008568:Memory / Q000187:drug effects; D008964:Molar, Third / Q000601:surgery; D010149:Postoperative Pain / Q000517:prevention & control*; D010894:Piroxicam / Q000008:administration & dosage / Q000031:analogs & derivatives*; D011292:Premedication; D015742:Propofol / Q000627:therapeutic use; D014081:Tooth Extraction / Q000009:adverse effects; D014313:Trismus / Q000209:etiology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D006993:Hypnotics and Sedatives; D010894:Piroxicam; D015742:Propofol; C032801:tenoxicam