An isobolographic analysis of drug interaction between intrathecal clonidine and baclofen in the formalin test in rats.
The inhibition of both phases of the formalin response by intrathecal (IT) clonidine and baclofen, given alone or in combination at a fixed dose ratio, was studied. Both drugs, at doses not affecting motor performance, produced a dose-dependent inhibition of phase 2 of the formalin test. The potency of baclofen and clonidine, defined by their ID50's for phase 2 of the formalin test, was 0.56 and 3.4 nmol, respectively. The combination ID50 of baclofen and clonidine, with the equieffective dose ratio of 1:6, was found to be statistically lower than the theoretical additive ID50. These data suggest that co-administration of alpha2-adrenoceptor or GABA(B) receptor agonists may prove therapeutically useful in treating chronic pain.
Department of Anaesthesiology and Intensive Therapy, Medical University School, Lublin, Poland.
K
K
Przesmycki
J A
JA
Dzieciuch
S J
SJ
Czuczwar
Z
Z
Kleinrok
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D003000:Clonidine / Q000494:pharmacology*; D004347:Drug Interactions; D005557:Formaldehyde; D018755:GABA Agonists / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology; D007278:Injections, Spinal; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D017288:Pain Threshold / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
D000316:Adrenergic alpha-Agonists; D000317:Adrenergic alpha-Antagonists; D018755:GABA Agonists; D007093:Imidazoles; C050701:atipamezole; D005557:Formaldehyde; D001418:Baclofen; D003000:Clonidine