Hydrogels of poly(ethylene glycol): mechanical characterization and release of a model drug.
Thermosensitive polymer networks were synthesized from poly(ethylene glycol), hexamethylene diisocyanate and 1,2,6-hexanetriol in stoichiometric proportions. By varying the amount of 1,2,6-hexanetriol and the molar mass of the poly(ethylene glycol), a wide range of networks with different crosslinking densities was prepared. The networks obtained were characterized by the temperature dependence of their degree of equilibrium swelling in water and by their Young's moduli. For each network, the molecular weight between crosslinks was estimated. The structure of the hydrogels was analysed with respect to scaling laws, and it was found that the results obtained with PEG 1500 and PEG 6000 hydrogels are in agreement with theoretical predictions, whereas those obtained with PEG 400 hydrogels are in disagreement. The release properties of PEG hydrogels were studied by the determination of the diffusion coefficient for acebutolol chlorhydrate and by an analysis of the effect of temperature on these coefficients. Finally, these release properties were correlated with the swelling and structural properties of the hydrogels.
Iza
M
M
Laboratoire de Physique Pharmaceutique, URA CNRS 1218, Faculté de Pharmacie, Université Paris-Sud, Chatenay-Malabry, France. mustapha.iza@phypha.u-psud.fr
Stoianovici
G
G
Viora
L
L
Grossiord
J L
JL
Couarraze
G
G
D000070:Acebutolol / Q000008:administration & dosage; D004058:Diffusion; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D008970:Molecular Weight; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000737:chemistry*; D013696:Temperature
D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols; D000070:Acebutolol