GABAB receptors: drugs meet clones.
Recently, the long-awaited cloning of the GABAB receptors, the last of the major known neurotransmitter receptors to be identified, has been reported. In addition to an emerging molecular understanding, there have been advances in discerning the specific coupling partners of GABAB receptors in the brain.
Bettler
B
B
Novartis Pharma, Basel, Switzerland. bernhard.bettler@pharma.novartis.com
Kaupmann
K
K
Bowery
N
N
D001418:Baclofen / Q000627:therapeutic use*; D001923:Brain Chemistry / Q000502:physiology; D003001:Cloning, Molecular; D018755:GABA Agonists / Q000627:therapeutic use*; D058786:GABA-B Receptor Agonists; D006801:Humans; D018080:Receptors, GABA-B / Q000737:chemistry / Q000235:genetics*; D015398:Signal Transduction / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D018755:GABA Agonists; D058786:GABA-B Receptor Agonists; D018080:Receptors, GABA-B; D005680:gamma-Aminobutyric Acid; D001418:Baclofen