Endothelial cells lining polyester fabric express pro-coagulant phenotype in vitro.
The paper deals with the in vitro assessment of endothelial cell (EC) phenotype covering an albumin- and chitosan-coated polyester fabric and shows that resting ECs express a pro-coagulant phenotype by releasing a high von Willebrand factor level and expressing low thrombomodulin surface activity, despite maintaining an adequate response to stimulating agents.
INSERM U 443, Université Victor Segalen Boreaux, France. U443@bordeaux.inserm.fr
M
M
Rémy
R
R
Bareille
F
F
Villars
F
F
Rouais
A
A
Gorodkov
L
L
Bordenave
D001672:Biocompatible Materials; D001777:Blood Coagulation; D004730:Endothelium, Vascular / Q000166:cytology* / Q000502:physiology*; D006801:Humans; D011091:Polyesters; D012333:RNA, Messenger / Q000032:analysis; D018180:Thrombomodulin / Q000235:genetics / Q000378:metabolism; D014471:Umbilical Veins / Q000166:cytology; D014841:von Willebrand Factor / Q000378:metabolism
D001672:Biocompatible Materials; D011091:Polyesters; D012333:RNA, Messenger; D018180:Thrombomodulin; D014841:von Willebrand Factor