Efficacy of topical treatment of pigmentation skin disorders with plant hydroquinone glucosides as assessed by quantitative color analysis.
Hydroquinone is a well known reagent used in the treatment of pigmentation disorders. The instability of the quinones and the required active concentration make topical treatment rather difficult. We tested the efficacy of an ascorbate-phytohydroquinone complex that inhibits the synthesis of melanin and promotes the degradation of the existing melanin. Lentigo senile lesions were evaluated before and after 1 month of treatment. Objective skin color evaluation was performed instrumentally. After one month of treatment, a clear depigmentation of the macules was measured. None of the volunteers reported any side effects from the prolonged treatment with the hydroquinone containing product.
Algemene en Biologische Scheikunde, Faculteit voor Lichamelijke Opvoeding en Kinesitherapie, Vrije Universiteit Brussel, Belgium.
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D000279:Administration, Cutaneous; D000368:Aged; D000369:Aged, 80 and over; D019661:Apiaceae; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000627:therapeutic use; D001585:Benzoyl Peroxide / Q000627:therapeutic use; D002957:Citrus; D003124:Colorimetry; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D005960:Glucosides / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D006873:Hydroquinones / Q000008:administration & dosage / Q000627:therapeutic use; D007911:Lentigo / Q000188:drug therapy*; D008297:Male; D008543:Melanins / Q000037:antagonists & inhibitors / Q000378:metabolism; D008875:Middle Aged; D009822:Oils, Volatile / Q000627:therapeutic use; D015125:Oxyquinoline / Q000627:therapeutic use; D010936:Plant Extracts / Q000627:therapeutic use; D012880:Skin Pigmentation / Q000187:drug effects
D003879:Dermatologic Agents; D004338:Drug Combinations; D005960:Glucosides; D006873:Hydroquinones; D008543:Melanins; D009822:Oils, Volatile; D010936:Plant Extracts; C096512:hydroquinoneglucoside; D015125:Oxyquinoline; C003284:quinoderm; D001205:Ascorbic Acid; D001585:Benzoyl Peroxide; C031927:hydroquinone