Thrombomodulin levels in Behçet's disease with and without the factor V Leiden mutation.
The plasma levels of thrombomodulin (TM) in 34 patients with Behçet's disease and 79 healthy control subjects were studied. Eight patients had the factor V Leiden (FVL) mutation. The TM level was significantly lower in patients with the FVL mutation than in patients without the mutation and in the healthy controls (p < 0.05 and p < 0.01). However, there was no difference in overall mean plasma TM concentration between the patients without the mutation and the healthy controls.
Department of Pediatric Hematology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
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Gürgey
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Gurler
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AF
Oner
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Mesci
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Kirazli
D001528:Behcet Syndrome / Q000097:blood* / Q000235:genetics*; D016009:Chi-Square Distribution; D004797:Enzyme-Linked Immunosorbent Assay; D005165:Factor V / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D009154:Mutation / Q000235:genetics*; D012016:Reference Values; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D018180:Thrombomodulin / Q000097:blood* / Q000235:genetics
D018180:Thrombomodulin; C095381:factor V Leiden; D005165:Factor V