Protective effects of an antiulcer agent, ecabet sodium on colorectal carcinogenesis in rodents.
A new antiulcer agent, ecabet sodium is one of dehydroabietic acid derivatives prepared from pine resin. The effects of ecabet sodium on colorectal carcinogenesis were investigated in azoxymethane-pretreated mice with chronic ulcerative colitis induced by 3 repeated administration of 3% dextran sulfate sodium and in 1, 2-dimethylhydrazine-treated rats. Although daily treatment with ecabet sodium did not affect the colorectal DNA-synthesizing enzyme activities and bromodeoxyuridine-immunoreactive S-phase cells, high-grade dysplasia in ecabet sodium-treated mice was less frequent than in untreated mice. In rats, ecabet sodium administration reduced the elevated activity of thymidylate synthetase in colorectal tumors.
Third Internal Medicine, Oita Medical University, Oita 879-55, Japan.
T
T
Yarimizu
T
T
Mitamura
S
S
Suzuki
S
S
Sakamoto
D019813:1,2-Dimethylhydrazine; D045784:Abietanes; D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D001397:Azoxymethane; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens; D003093:Colitis, Ulcerative / Q000139:chemically induced / Q000150:complications*; D003106:Colon / Q000187:drug effects / Q000473:pathology; D015179:Colorectal Neoplasms / Q000139:chemically induced / Q000201:enzymology / Q000473:pathology / Q000517:prevention & control*; D004224:Diterpenes / Q000627:therapeutic use*; D005260:Female; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009929:Organ Size / Q000187:drug effects; D011230:Precancerous Conditions / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control; D051381:Rats; D011919:Rats, Inbred Strains; D012007:Rectum / Q000187:drug effects / Q000473:pathology; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors / Q000096:biosynthesis
D045784:Abietanes; D016588:Anticarcinogenic Agents; D002273:Carcinogens; D004224:Diterpenes; C061681:ecabet; D013940:Thymidylate Synthase; D019813:1,2-Dimethylhydrazine; D001397:Azoxymethane