Emotional aspects of hyperprolactinemia.
Patients with hyperprolactinemia often present with emotional difficulties. These occasionally persist even after successful treatment. Insight into the roots of their diseased state makes a difference in the handling of all cases, but becomes crucial in the not-so-rare situations in which the normalization of hormonal levels is not followed by a feeling of cure. This chapter attempts to provide details, discuss and situate in context the following blocks of pertinent information: (1) prolactin acts upon the central nervous system and variations in its concentrations do affect mood, emotions and behavior; (2) most actions of prolactin are directed to metabolical and behavioral adaptation to pregnancy and the care of the young; (3) even in the absence of pregnancy prolactin secretion responds to environmental stimuli under specific conditions. Whether adaptive, as in the case of surrogate maternity, or pathological, as in the case of pseudopregnancy, prolactin responds to a perceived need to take care of a child; (4) the facts that the clinical onset of prolactinomas often follows life-events and that these tumors occur preferentially in women brought up under specific conditions suggest the possibility that psychological factors may predispose to prolactinomas; (5) dealing with individual cases requires the perception that the relations between prolactin, emotions and feelings are circular, i.e., prolactin affects the brain and mood but, on the other hand, personality traits and environmental factors may stimulate the secretion of prolactin and may play a role in the genesis of the disease.
Sobrinho
L G
LG
Department of Endocrinology, Portuguese Cancer Institute, Lisboa, Portugal. sobrinho@esoterica.pt
D000342:Affective Symptoms / Q000209:etiology* / Q000628:therapy; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000523:psychology*; D008016:Life Change Events; D008425:Maternal Behavior / Q000523:psychology; D010911:Pituitary Neoplasms / Q000523:psychology; D011247:Pregnancy; D011388:Prolactin / Q000494:pharmacology*; D015175:Prolactinoma / Q000523:psychology
D011388:Prolactin