Some reactions of 2-cyanomethylimidazo[4,5-b]pyridine with isothiocyanates. Antituberculotic activity of the obtained compounds.
Some reactions of 2-cyanomethylimidazo[4,5-b]pyridine with isothiocyanates were carried out. New derivatives of imidazo[4,5-b]pyridine with different substituents in 2-position and derivatives of the new thiazolo-pyrido-imidazo-pyrimidine ring system were synthesized. Most of the obtained compounds were tested in vitro for their antituberculotic activity.
Department of Organic Chemistry, Medical University of Gdańsk, Warsaw, Poland.
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Bukowski
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Janowiec
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Zwolska-Kwiek
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Andrzejczyk
D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D017953:Isocyanates / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared
D000995:Antitubercular Agents; D007093:Imidazoles; D017953:Isocyanates; D011725:Pyridines; C049691:2-cyanomethylimidazo(4,5-b)pyridine