Aneurysmal bone cysts: percutaneous embolization with an alcoholic solution of zein--series of 18 cases.
OBJECTIVE
To assess the efficacy of percutaneous embolization with an alcoholic solution of zein in the treatment of aneurysmal bone cysts.


METHODS
Eighteen patients with aneurysmal bone cysts were treated percutaneously with alcoholic zein. The cysts were in the lower limb (n = 7), upper limb (n = 5), pelvis (n = 3), cervical spine (n = 2), and mandible (n = 1). All patients were symptomatic, three had previously undergone surgery. Percutaneous embolization was performed with fluoroscopic or computed tomographic guidance with the patient under general anesthesia. Clinical and imaging follow-up lasted 18 months to 4 years.


RESULTS
Percutaneous embolization was performed in 16 cases. In two cases, cystograms showed marked venous drainage and thus embolization was not attempted. Six patients underwent repeat embolization. Complications consisted of a local transitory inflammatory reaction (n = 5), aseptic osteitis (n = 1), and a small pulmonary infarct without sequelae (n = 1). Relief of symptoms was achieved in all patients except one, who underwent surgery. At imaging, improvement was total in 13 cases (87%) and partial in two cases (13%). No recurrence was noted during follow-up.


CONCLUSIONS
Percutaneous embolization of aneurysmal bone cysts with alcoholic zein should be considered a reliable alternative to surgery, especially in cases with a difficult surgical approach or cases of postsurgical recurrence.
Department of Pediatric Imaging, Hôpital Debrousse, Université Lyon-Sud, France.
L
L
Guibaud
D
D
Herbreteau
J
J
Dubois
N
N
Stempfle
J
J
Bérard
J P
JP
Pracros
J J
JJ
Merland
D000293:Adolescent; D017824:Bone Cysts, Aneurysmal / Q000000981:diagnostic imaging / Q000628:therapy*; D001842:Bone and Bones / Q000000981:diagnostic imaging; D002648:Child; D002675:Child, Preschool; D003973:Diatrizoate / Q000627:therapeutic use*; D004338:Drug Combinations; D004621:Embolization, Therapeutic; D005227:Fatty Acids / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011409:Propylene Glycols / Q000627:therapeutic use*; D012597:Sclerosing Solutions; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D015028:Zein / Q000627:therapeutic use*
D004338:Drug Combinations; D005227:Fatty Acids; D011409:Propylene Glycols; D012597:Sclerosing Solutions; D003973:Diatrizoate; D015028:Zein; C020481:alcoholic prolamine solution