Comparative investigation of the long non-coding M-F genome region of wild-type and vaccine measles viruses.
The sequence of the 300 nucleotides region of the measles virus genome was determined that includes a part of the 3'-untranslated region of the matrix (M) gene, the intergenic region and a part of the 5'-untranslated region of the fusion (F) gene [M-F region] for vaccine strain Leningrad-16 and 14 wild-type isolates. The data obtained demonstrate the variability of this long non-coding M-F region. No mutations in this region of the genome were found which seem to be specific for vaccine strains of measles virus (MV).
Research Institute of Viral Preparations, Russian Academy of Medical Sciences, Moscow, Russia.
A
A
Heider
S
S
Santibanez
A
A
Tischer
E
E
Gerike
N
N
Tikhonova
G
G
Ignatyev
M
M
Mrazova
G
G
Enders
E
E
Schreier
D000818:Animals; D001483:Base Sequence; D002522:Chlorocebus aethiops; D004279:DNA, Viral; D016679:Genome, Viral; D006801:Humans; D008458:Measles Vaccine / Q000235:genetics*; D008459:Measles virus / Q000145:classification / Q000235:genetics*; D008969:Molecular Sequence Data; D010802:Phylogeny; D012689:Sequence Homology, Nucleic Acid; D014709:Vero Cells; D014760:Viral Fusion Proteins / Q000235:genetics*; D014763:Viral Matrix Proteins / Q000235:genetics*
D004279:DNA, Viral; D008458:Measles Vaccine; D014760:Viral Fusion Proteins; D014763:Viral Matrix Proteins