NK cells can recognize different forms of class I MHC.
NK recognition and lysis of targets are mediated by activation receptor(s) whose effects may be over-ridden by inhibitory receptors recognizing class I MHC on the target. Incubation of normal lymphoblasts with a peptide that can bind to their class I MHC renders them sensitive to lysis by syngeneic NK cells. By binding to class I MHC, the peptide alters or masks the target structure recognized by an inhibitory NK receptor(s). This target structure is most likely an "empty" dimer of class I heavy chain and beta2m as opposed to a "full" class I trimer formed by binding of specific peptide that is recognized by CTL.
Su
R C
RC
Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Canada.
Kung
S K
SK
Gariépy
J
J
Barber
B H
BH
Miller
R G
RG
D000595:Amino Acid Sequence; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000950:Antigens, Ly; D000954:Antigens, Surface / Q000378:metabolism; D020126:Brefeldin A; D003208:Concanavalin A / Q000494:pharmacology; D003517:Cyclopentanes / Q000494:pharmacology; D003601:Cytotoxicity Tests, Immunologic; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D006183:H-2 Antigens / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis / Q000187:drug effects / Q000378:metabolism*; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D037181:Lectins, C-Type; D008213:Lymphocyte Activation; D018942:Macrolides; D008562:Membrane Glycoproteins / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008819:Mice, Nude; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000276:immunology / Q000378:metabolism; D011485:Protein Binding / Q000276:immunology; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D011971:Receptors, Immunologic / Q000276:immunology; D054340:Receptors, KIR; D055630:Receptors, NK Cell Lectin-Like; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D013997:Time Factors
D000900:Anti-Bacterial Agents; D000950:Antigens, Ly; D000954:Antigens, Surface; D003517:Cyclopentanes; D006183:H-2 Antigens; D015395:Histocompatibility Antigens Class I; D037181:Lectins, C-Type; D018942:Macrolides; D008562:Membrane Glycoproteins; D010446:Peptide Fragments; D011500:Protein Synthesis Inhibitors; D011971:Receptors, Immunologic; D054340:Receptors, KIR; D055630:Receptors, NK Cell Lectin-Like; D003208:Concanavalin A; D020126:Brefeldin A