Unc-1: a stomatin homologue controls sensitivity to volatile anesthetics in Caenorhabditis elegans.
To identify sites of action of volatile anesthetics, we are studying genes in a functional pathway that controls sensitivity to volatile anesthetics in the nematode Caenorhabditis elegans. The unc-1 gene occupies a central position in this pathway. Different alleles of unc-1 have unique effects on sensitivity to the different volatile anesthetics. UNC-1 shows extensive homology to human stomatin, an integral membrane protein thought to regulate an associated ion channel. We postulate that UNC-1 has a direct effect on anesthetic sensitivity in C. elegans and may represent a molecular target for volatile anesthetics.
Rajaram
S
S
Departments of Anesthesiology and Genetics, University Hospitals, Case Western Reserve University, Cleveland, OH 44106, USA.
Sedensky
M M
MM
Morgan
P G
PG
D000595:Amino Acid Sequence; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D000818:Animals; D001483:Base Sequence; D001798:Blood Proteins / Q000235:genetics*; D017173:Caenorhabditis elegans / Q000235:genetics*; D029742:Caenorhabditis elegans Proteins; D017931:DNA Primers; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid
D018685:Anesthetics, Inhalation; D001798:Blood Proteins; D029742:Caenorhabditis elegans Proteins; D017931:DNA Primers; D008565:Membrane Proteins; C036860:STOM protein, human; C113701:Unc-1 protein, C elegans