Nd: YAG interstitial laser thermotherapy in the treatment of breast cancer.
OBJECTIVE
"Minimal treatment strategy" is desirable in certain breast cancer patients. The main objective of the present study is to examine the use of interstitial laser thermotherapy (laserthermia) for this purpose.


METHODS
Thirty-five patients with primary breast cancer were treated with laserthermia using the Nd:YAG (1,064 nm) pulse-wave laser. In 28 patients, laserthermia was performed before radical resection, and in seven patients it was the only invasive treatment.


RESULTS
One gaseous rupture of tumor occurred at 3 Watts. The diameter of single focus of laser-induced damage after 1-2 Watts was less than 1 cm, and after 2.5-6 Watts it reached 1.5-2.5 cm. Of seven patients treated without surgery, local tumor control was achieved in five, and in three stage I-III patients disease-free survival followed for 19-60 months. After laserthermia plus surgery, 3-year disease-free survival was 27% in premenopausal and 92% in menopausal patients.


CONCLUSIONS
It seems that laser destruction of relatively small primary breast cancer is possible. Provisionally, laserthermia should not be used in premenopausal patients.
Ultrasound Studio, Kharkov, Ukraine. root@yard.kharkov.ua
A B
AB
Akimov
V E
VE
Seregin
K V
KV
Rusanov
E G
EG
Tyurina
T A
TA
Glushko
V P
VP
Nevzorov
O F
OF
Nevzorova
E V
EV
Akimova
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D016009:Chi-Square Distribution; D003198:Computer Simulation; D018572:Disease-Free Survival; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D053685:Laser Therapy; D007834:Lasers / Q000009:adverse effects; D008875:Middle Aged; D010865:Pilot Projects