On the employment of lambda carrageenan in a matrix system. III. Optimization of a lambda carrageenan-HPMC hydrophilic matrix.
The lambda carrageenan/HPMC ratio in matrix tablets has been optimized in order to obtain pH-independent release profiles of chlorpheniramine maleate, a freely soluble drug. Release profiles in acidic (pH1.2) and neutral (pH 6.8) media were fitted according to the Weibull and the power law models. Model independent parameters(t50% and the percentage of drug released after 2 h) were also calculated. The Weibull parameters were found suitable to describe the dependence of the release profiles on matrix composition. Preparation and testing of the optimized formulation showed linear and pH-independent release profiles lasting about 24 h, in good accordance with the values predicted by the optimization procedure.
Department of Pharmaceutical Chemistry, University of Pavia, Italy.
M C
MC
Bonferoni
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S
Rossi
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F
Ferrari
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M
Bertoni
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GK
Bolhuis
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Caramella
D002351:Carrageenan / Q000737:chemistry*; D003692:Delayed-Action Preparations; D006863:Hydrogen-Ion Concentration; D007785:Lactose / Q000031:analogs & derivatives* / Q000737:chemistry; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D008962:Models, Theoretical; D010078:Oxazines; D012044:Regression Analysis
D003692:Delayed-Action Preparations; D010078:Oxazines; D002351:Carrageenan; D008747:Methylcellulose; C071191:MK 458; D007785:Lactose