[Evaluation of the effects of bioadhesive substances as addition to oral contrast media: an experimental study].
OBJECTIVE
To evaluate the additional effect of bioadhesives in combination with iotrolan and barium as oral contrast media in an animal model.


METHODS
The bioadhesives Noveon, CMC, Tylose and Carbopol 934 were added to iotrolan and barium. The solutions were administered to rabbits by a feeding tube. The animals were investigated by computed tomography (CT) and radiography after 0.5, 4, 12, 24 and in part after 48 hours. Mucosal coating and contrast filling of the bowel were evaluated.


RESULTS
Addition of bioadhesives to oral contrast media effected long-term contrast in the small intestine and colon, but no improvement in continuous filling and coating of the gastrointestinal tract was detected. Mucosal coating was seen only in short regions of the caecum and small intestine. In CT the best results for coating were observed with tylose and CMC, in radiography additionally with carbopol and noveon. All contrast medium were well tolerated.


CONCLUSIONS
The evaluated contrast medium solutions with bioadhesives have shown long-term contrast but no improvement in coating in comparison to conventional oral contrast media.
Conrad
R
R
Radiologische Universitätsklinik Bonn.
Schneider
G
G
Textor
J
J
Fimmers
R
R
Sachse
A
A
Schild
H H
HH
D000180:Acrylic Resins / Q000008:administration & dosage; D000268:Adhesiveness; D000269:Adhesives / Q000008:administration & dosage*; D000284:Administration, Oral; D000818:Animals; D001466:Barium Sulfate / Q000008:administration & dosage; D002266:Carboxymethylcellulose Sodium / Q000008:administration & dosage; D003287:Contrast Media / Q000008:administration & dosage*; D004064:Digestive System / Q000000981:diagnostic imaging*; D004337:Drug Carriers; D004341:Drug Evaluation; D005782:Gels; D008747:Methylcellulose / Q000008:administration & dosage / Q000031:analogs & derivatives; D010592:Pharmaceutic Aids; D011145:Polyvinyls / Q000008:administration & dosage; D011817:Rabbits; D014057:Tomography, X-Ray Computed; D014283:Triiodobenzoic Acids / Q000008:administration & dosage
D000180:Acrylic Resins; D000269:Adhesives; D003287:Contrast Media; D004337:Drug Carriers; D005782:Gels; D010592:Pharmaceutic Aids; D011145:Polyvinyls; D014283:Triiodobenzoic Acids; C006912:carboxypolymethylene; C033300:iotrolan; D001466:Barium Sulfate; C030312:calcium polycarbophil; C013124:methylethylcellulose; D008747:Methylcellulose; D002266:Carboxymethylcellulose Sodium