Renal tubular dysgenesis in twins.
In a fetal autopsy series, we have explored the occurrence of renal tubular dysgenesis in twins. Renal tubular dysgenesis was found exclusively among those monozygotic twins with evidence of twin transfusion syndrome, particularly in those donor twins with oligohydramnios and growth restriction. We infer that hypotension in the donor twin of the twin transfusion syndrome pair is responsible for the failure of proximal convoluted tubule differentiation, and the disturbance of renal function is manifested as oligohydramnios prenatally, and either oliguria or tubular dysfunction postnatally.
Department of Pediatrics, University of Michigan, Ann Arbor 48109, USA.
M
M
Barr
A B
AB
Sedman
K P
KP
Heidelberger
D000886:Anthropometry; D005260:Female; D005313:Fetal Death; D005330:Fetofetal Transfusion; D006801:Humans; D007684:Kidney Tubules / Q000002:abnormalities*; D011247:Pregnancy; D014427:Twins