Intrathecal administration of sameridine to patients subjected to arthroscopic knee joint surgery.
BACKGROUND
Sameridine, a new substance with both local anesthetic and opioid effects, was administered intrathecally for the first time to humans, i.e. in patients subjected to arthroscopic knee joint surgery.


METHODS
A dose-escalating (10, 15, 20 and 25 mg), open study was performed in 33 patients. Only two patients were included in the 25 mg group.


RESULTS
Sameridine provided good quality of surgical anesthesia in all patients except those receiving 10 mg. The maximum level of sensory block, Th5-Th7, was reached within 30 min with a median duration of 3.6-3.9 h. The motor block was more profound with increasing dose, but never lasted longer than the sensory block. The influence on heart rate and blood pressure was minor and atropine and ephedrine were needed in four patients. No clinically significant ECG-changes were detected and no arrhythmias were recorded. Oxygen saturation and respiratory rate did not decrease in a clinically significant way and were not affected by concomitant morphine given i.v. postoperatively. There were few side-effects, the most frequent being mild pruritus (10/33).


CONCLUSIONS
Sameridine provided clinically adequate anesthesia for the patients receiving the doses of 15, 20 and 25 mg. Further studies are needed to evaluate the substance and it is of great interest to clinically investigate the opioid component with respect to postoperative analgesia.
Department of Anesthesiology, Karolinska Hospital, Stockholm, Sweden.
L
L
Westman
A
A
Valentin
E
E
Eriksson
A
A
Ekblom
D000293:Adolescent; D000328:Adult; D000775:Anesthesia, Spinal; D000779:Anesthetics, Local / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D001182:Arthroscopy; D004562:Electrocardiography / Q000187:drug effects; D004724:Endoscopy; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007278:Injections, Spinal; D007431:Intraoperative Complications; D007719:Knee Joint / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D019148:Neuromuscular Blockade; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy; D010880:Piperidines / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D015656:Respiratory Mechanics / Q000187:drug effects
D000779:Anesthetics, Local; D010880:Piperidines; C113809:sameridine