Duration of neurofibrillary changes in the hippocampal pyramidal neurons.
The total number of neurons with and without neurofibrillary changes in sectors CA1 to CA4, subiculum, and dentate gyrus of 16 subjects with Alzheimer disease (AD) was estimated. The duration of neurofibrillary changes was calculated on the basis of regressions between the duration of AD and neuronal numbers. In the CA1 and subiculum, it takes 3.4 and 5.4 years, respectively, for an intact neuron affected by neurofibrillary pathology to become a ghost tangle.
Department of Pathological Neurobiology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA.
M
M
Bobinski
J
J
Wegiel
M
M
Tarnawski
M J
MJ
de Leon
B
B
Reisberg
D C
DC
Miller
H M
HM
Wisniewski
D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology*; D002102:Cadaver; D002452:Cell Count; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D016874:Neurofibrillary Tangles / Q000473:pathology*; D017966:Pyramidal Cells / Q000473:pathology*; D013997:Time Factors