Peripheral retinal neovascularization (Eales disease) associated with the factor V Leiden mutation.
OBJECTIVE
To illustrate a case of peripheral retinal neovascularization (Eales disease) in a patient who tested positive for the factor V Leiden mutation.


METHODS
A 42-year-old woman had a 1-week history of blurred vision in her right eye. Her medical history was remarkable for a cerebrovascular accident. Ophthalmoscopy of the right eye disclosed a mild vitreous hemorrhage and a ridge of retinal neovascularization in the temporal periphery. The left fundus showed evidence of temporal retinal ischemia. A laboratory evaluation for hypercoagulability was positive for factor V Leiden mutation.


RESULTS
Peripheral scatter laser photocoagulation was applied to the ischemic retina, and the neovascularization regressed. The patient began taking warfarin sodium to prevent further thrombotic events.


CONCLUSIONS
A laboratory evaluation for coagulopathy, including the factor V Leiden mutation, should be added to the examination of patients with Eales disease, especially individuals with a history of a previous thrombotic event.
Department of Ophthalmology, University of Pittsburgh School of Medicine, The Eye and Ear Institute, PA 15213, USA. aeller@vision.eei.upmc.edu
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D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage; D005165:Factor V / Q000235:genetics*; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D007511:Ischemia / Q000235:genetics / Q000473:pathology; D017075:Laser Coagulation; D009154:Mutation; D015861:Retinal Neovascularization / Q000235:genetics* / Q000601:surgery; D012171:Retinal Vessels / Q000473:pathology; D014657:Vasculitis / Q000235:genetics; D014823:Vitreous Hemorrhage / Q000235:genetics / Q000473:pathology; D014859:Warfarin / Q000008:administration & dosage
D000925:Anticoagulants; C095381:factor V Leiden; D014859:Warfarin; D005165:Factor V