[Changes in calcium homeostasis in the development of diabetes mellitus].
The review analyzes the mechanisms of hormonal regulation of the exchange of Ca ions in the organisms and the role of changes in their extra- and intracellular balance in the development of diabetes mellitus. Recent data about changes in intracellular Ca homeostasis which lead to alterations in insulin secretion are presented. A conclusion is made about tight connections of disturbances in hormonal and calcium homeostasis in the pathogenesis of diabetes and its complications.
Institute of Endocrinology and Metabolism, Academy of Medical Sciences, Kiev, Ukraine.
Ie P
IeP
Kostiuk
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000209:etiology / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000209:etiology / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D014807:Vitamin D / Q000378:metabolism
D007328:Insulin; D014807:Vitamin D; D002118:Calcium