Upper gastrointestinal disease in patients with familial adenomatous polyposis.
BACKGROUND
Upper gastrointestinal disease has become an important aspect in the management of patients with familial adenomatous polyposis (FAP).


METHODS
A review of the literature was carried out using Medline. Epidemiology, pathology and treatment options are considered.


CONCLUSIONS
Despite the fact that over 90 per cent of patients with FAP develop duodenal adenomas, only 5 per cent go on to develop cancer. In the absence of methods to detect who is at risk of cancer, all patients undergo regular endoscopic surveillance at present. Chemoprevention in the form of drug therapy may be the answer to controlling the disease.
St Mark's Hospital, Harrow, UK.
M H
MH
Wallace
R K
RK
Phillips
D011125:Adenomatous Polyposis Coli / Q000150:complications* / Q000453:epidemiology / Q000473:pathology; D001646:Bile; D004379:Duodenal Neoplasms / Q000209:etiology* / Q000235:genetics / Q000628:therapy; D016158:Genes, p53 / Q000235:genetics; D006801:Humans; D009154:Mutation; D013274:Stomach Neoplasms / Q000209:etiology* / Q000235:genetics / Q000628:therapy