Postcoital contraceptive activity of some indigenous plants in rats.
Crude ethanolic extract of seeds of Cichorium intybus and aerial parts of Guetterda andamanica, Memcylon lushingtonii, and Solanum crassypetalum and their fractions were evaluated for postcoital contraceptive efficacy in adult female Sprague-Dawley rats. The extracts were administered orally in days 1-10 postcoitum, and significant contraceptive activity was observed. On fractionation, the activity was localized primarily in the chloroform- or butanol-insoluble fractions. The activity in these fractions was invariably associated with a significantly reduced number of implantations.
Division of Endocrinology, Central Drug Research Institute, Lucknow, India.
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Keshri
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Lakshmi
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Singh
D000818:Animals; D018651:Cichorium intybus; D003281:Contraceptives, Postcoital; D003307:Copulation; D010064:Embryo Implantation / Q000187:drug effects; D000431:Ethanol; D005260:Female; D010936:Plant Extracts / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds; D013997:Time Factors
D003281:Contraceptives, Postcoital; D010936:Plant Extracts; D000431:Ethanol