Kinking and stenosis of the carotid artery associated with homolateral ischaemic brain infarction in a patient treated with cyclosporin A.
We present a 3-year-old patient with stenotic kinking of the left internal carotid artery (ICA) who developed an ischaemic infarction of the left brain hemisphere followed by severe neurological sequelae after a prolonged generalized seizure. At time of the seizure the boy was in biological remission of a nephrotic syndrome and received prednisolone and cyclosporin A (CsA) treatment. The haemodynamic consequences of inborn kinking of the ICA is discussed controversely in the literature. The presented case shows that stenotic kinking of the ICA may significantly impair the blood flow towards the homolateral hemisphere and therefore may result in an ischaemic infarction. The influence of CsA on seizure activity is discussed.


CONCLUSIONS
This case provides clinical and radiological evidence supporting an association between stenotic kinking of the carotid artery and homolateral hemispheric brain infarction.
Department of Paediatrics, University of Vienna, Austria.
M
M
Huemer
W
W
Emminger
S
S
Trattnig
M
M
Freilinger
K
K
Wandl-Vergesslich
D002343:Carotid Artery, Internal; D016893:Carotid Stenosis / Q000150:complications* / Q000209:etiology; D002544:Cerebral Infarction / Q000150:complications* / Q000209:etiology; D002675:Child, Preschool; D016572:Cyclosporine / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D009404:Nephrotic Syndrome / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D011239:Prednisolone