Role of vasoactive mediators in primary and secondary pulmonary hypertension.
The role of vasoactive mediators, such as endothelin-1, nitric oxide, prostacyclin, and thromboxane, in pulmonary hypertension remains undefined. This study investigated the circulating levels and transpulmonary gradients of these vasoactive mediators in patients with primary and secondary pulmonary hypertension to define whether there is increased production or decreased clearance of these substances in the lung vasculature.
Mikhail
G
G
National Heart and Lung Institute of Imperial College, Harefield Hospital, Middlesex, United Kingdom.
Chester
A H
AH
Gibbs
J S
JS
Borland
J A
JA
Banner
N R
NR
Yacoub
M H
MH
D000328:Adult; D000959:Antihypertensive Agents / Q000097:blood*; D019332:Endothelin-1 / Q000097:blood; D011464:Epoprostenol / Q000097:blood; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D013928:Thromboxane A2 / Q000097:blood; D014664:Vasodilation
D000959:Antihypertensive Agents; D019332:Endothelin-1; D009569:Nitric Oxide; D013928:Thromboxane A2; D011464:Epoprostenol