Reactive hemophagocytosis in systemic lupus erythematosus.
A patient with systemic lupus erythematosus (SLE) developed reactive hemophagocytosis. This case did not show any underlying diseases such as infection or malignancy other than SLE itself. The mechanisms inducing hemophagocytosis in SLE seem to be heterogeneous and remain to be elucidated. Although an immune complex-mediated mechanism in cases with acute lupus hemophagocytic syndrome has been proposed, we suggest the possible involvement of IL-1beta as the pathogenesis of our case.
Third Division of Internal Medicine, Shimane Medical University.
K
K
Takahashi
S
S
Kumakura
H
H
Ishikura
Y
Y
Murakawa
Y
Y
Yamauchi
S
S
Kobayashi
D000328:Adult; D000936:Antigen-Antibody Complex / Q000502:physiology; D001853:Bone Marrow / Q000473:pathology; D006644:Histiocytes / Q000276:immunology / Q000473:pathology; D015616:Histiocytosis, Non-Langerhans-Cell / Q000150:complications* / Q000209:etiology / Q000473:pathology; D006801:Humans; D007375:Interleukin-1 / Q000502:physiology; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000276:immunology; D008297:Male; D010587:Phagocytosis
D000936:Antigen-Antibody Complex; D007375:Interleukin-1