[The effect of cytostatic therapy on the indices of the humoral factors in body nonspecific reactivity in patients with chronic lympholeukemia].
Overall, thirty-five patients with chronic lymphoid leukemia in the advanced stage were examined. Results of the findings obtained show that the first course of chemotherapy does not have significant effect on general lytic activity of complement and opsonic activity of blood serum but inhibits activity of classical and alternative paths of complement. Repeated courses of chemotherapy make for depression of general lytic activity of complement as well as classical and alternative paths of the complement system.
Daniliuk
I I
II
D000917:Antibody Formation / Q000187:drug effects; D018906:Antineoplastic Agents, Alkylating / Q000494:pharmacology / Q000627:therapeutic use*; D001782:Blood Donors; D003520:Cyclophosphamide / Q000494:pharmacology / Q000627:therapeutic use*; D003864:Depression, Chemical; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy* / Q000276:immunology*
D018906:Antineoplastic Agents, Alkylating; D003520:Cyclophosphamide