A case of angiokeratoma circumscriptum: immunolocalization of matrix metalloproteinase (MMP)-9.
We report a case of angiokeratoma circumscriptum which we have followed for one year. The skin lesion initially showed erythema and then changed to a dark reddish, raised, keratotic nodule. The lesion histologically showed dilated capillaries and hyperkeratosis. Using immunohistochemistry, matrix metalloproteinase (MMP)-9 was localized in the epidermis just under the horny layer, particularly in the hyperkeratotic lesion. The expression of MMP-9 might be related to the hyperkeratotic changes in this lesion.
Department of Dermatology, Saiseikai Yokohamashi Nanbu Hospital, Yokohama, Japan.
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Kobayashi
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Sakuraoka
D000794:Angiokeratoma / Q000098:blood supply / Q000201:enzymology / Q000473:pathology*; D002196:Capillaries / Q000473:pathology; D002675:Child, Preschool; D017364:Collagenases / Q000032:analysis* / Q000235:genetics; D004108:Dilatation, Pathologic / Q000473:pathology; D004817:Epidermis / Q000201:enzymology / Q000473:pathology; D004890:Erythema / Q000473:pathology; D005500:Follow-Up Studies; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D015603:Keratinocytes / Q000201:enzymology / Q000473:pathology; D007642:Keratosis / Q000473:pathology; D008297:Male; D020780:Matrix Metalloproteinase 9; D012878:Skin Neoplasms / Q000098:blood supply / Q000201:enzymology / Q000473:pathology*
D017364:Collagenases; D020780:Matrix Metalloproteinase 9