Skin atrophy of the eyelid induced by topical ophthalmic corticosteroids.
A case of eyelid skin atrophy caused by long-term application of topical ophthalmic corticosteroids for chronic uveitis is reported. Skin punch biopsy of the uveitic eye showed moderate atrophy of both epidermis and dermis (compared to normal skin on the other eye) resulting from a reduction in the three main fibrous components of the skin, namely type I and type III collagens, and elastic fibers. To our knowledge, this is the first report of skin atrophy in this association.
Neittaanmäki
H
H
Department of Dermatology, Savonlinna Central Hospital, Finland.
Kontkanen
M
M
Kallioinen
M
M
D000287:Administration, Topical; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001284:Atrophy / Q000139:chemically induced; D003094:Collagen / Q000378:metabolism; D005141:Eyelid Diseases / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D005260:Female; D005938:Glucocorticoids; D006801:Humans; D007124:Immunoenzyme Techniques; D009883:Ophthalmic Solutions; D012867:Skin / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D012871:Skin Diseases / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D014605:Uveitis / Q000188:drug therapy
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D009883:Ophthalmic Solutions; D003094:Collagen