CD4+ and CD8+ T-lymphocytopenia in a filly with Pneumocystis carinii pneumonia.
Decreased proportion of CD4+ and CD8+ T lymphocytes in peripheral blood likely contributed to susceptibility to Pneumocystis carinii in a foal. Cytological evaluation of bronchoalveolar lavage was required for identification of the pathogen and serial flow-cytometric analysis of peripheral blood lymphocytes documented transient low expression of CD4+ and CD8+ T lymphocytes. Although immunodeficiency is uncommon, it must be included in the differential diagnosis for patients suffering from chronic or opportunistic infections and may provide an indication for immunostimulant therapy.
Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan 66506-5606, USA.
M J
MJ
Flaminio
B R
BR
Rush
J H
JH
Cox
W E
WE
Moore
D000818:Animals; D015496:CD4-Positive T-Lymphocytes; D018414:CD8-Positive T-Lymphocytes; D003937:Diagnosis, Differential; D005260:Female; D006734:Horse Diseases / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D006736:Horses; D008231:Lymphopenia / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D011020:Pneumonia, Pneumocystis / Q000175:diagnosis / Q000276:immunology / Q000662:veterinary*