Decrease of protein kinase C in the spinal motor neurons of amyotrophic lateral sclerosis.
The expression of protein kinase C (PKC), a calcium- and phospholipid-dependent signaling molecule, was studied immunohistochemically in the spinal motor neurons of cases of sporadic amyotrophic lateral sclerosis (SALS). In the normal spinal cord, intense PKC immunoreactivity was found in subsets of large motor neurons. PKC immunoreactivity was markedly decreased in the spinal motor neurons of SALS. The result suggests that down-regulation of PKC is associated with the degeneration of spinal motor neurons in SALS.
Nagao
M
M
Department of Neurology, Tokyo Metropolitan Neurological Hospital, Fuchu, Japan.
Kato
S
S
Oda
M
M
Hirai
S
S
D000690:Amyotrophic Lateral Sclerosis / Q000201:enzymology* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000201:enzymology* / Q000473:pathology; D016612:Paraffin Embedding; D011493:Protein Kinase C / Q000378:metabolism*; D013116:Spinal Cord / Q000201:enzymology* / Q000473:pathology
D011493:Protein Kinase C