Bezafibrate has an antioxidant effect: peroxisome proliferator-activated receptor alpha is associated with Cu2+, Zn2+-superoxide dismutase in the liver.
Administration of bezafibrate in rats significantly reduced the levels of plasma thiobarbituric acid-reactive substances (TBARS) in comparison with those obtained in rats fed a soy or lard chow. Moreover, an elevation of in vitro conjugated diene production and linoleic acid levels in the high-density lipoproteins and low-density lipoproteins induced by a soy or lard chow, was reduced by bezafibrate administration. In addition, the liver Cu2+, Zn2+-superoxide dismutase (SOD) gene expression showed a significant positive correlation with the liver peroxisome proliferator-activated receptor alpha (PPARalpha) mRNA level (R=0.769, p<0.0001). This unique characteristic of bezafibrate, which possesses both a hypolipidemic effect and antioxidant activity, may be beneficial in preventing vascular complications in hyperlipidemia.
The Fourth Department of Medicine, Saitama Medical School, Japan.
I
I
Inoue
S
S
Noji
T
T
Awata
K
K
Takahashi
T
T
Nakajima
M
M
Sonoda
T
T
Komoda
S
S
Katayama
D042962:Acyl-CoA Oxidase; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001629:Bezafibrate / Q000494:pharmacology*; D002374:Catalase / Q000096:biosynthesis / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage; D005227:Fatty Acids / Q000097:blood; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008075:Lipoproteins, HDL / Q000032:analysis / Q000097:blood; D008077:Lipoproteins, LDL / Q000032:analysis / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000201:enzymology* / Q000648:ultrastructure; D008297:Male; D010088:Oxidoreductases / Q000096:biosynthesis / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D018160:Receptors, Cytoplasmic and Nuclear / Q000096:biosynthesis / Q000502:physiology*; D013025:Glycine max; D013482:Superoxide Dismutase / Q000096:biosynthesis*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014157:Transcription Factors / Q000096:biosynthesis / Q000502:physiology*
D000975:Antioxidants; D004041:Dietary Fats; D005227:Fatty Acids; D000960:Hypolipidemic Agents; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D018160:Receptors, Cytoplasmic and Nuclear; D017392:Thiobarbituric Acid Reactive Substances; D014157:Transcription Factors; D002784:Cholesterol; D010088:Oxidoreductases; D002374:Catalase; D013482:Superoxide Dismutase; D042962:Acyl-CoA Oxidase; D001629:Bezafibrate