Sequential methothrextate and 5-fruororacil therapy for diffuse bone metastasis from gastric cancer.
We herein present a case of diffuse bone metastasis from early gastric cancer with disseminated intravascular coagulation (DIC) in a 40-year old man, who had undergone a curative gastrectomy and had no evidence of recurrence for five years after surgery. The patient was treated with an intravenous administration of sequential methothrexate (MTX) and 5-fluorouracil (5-FU), and demonstrated a favorable clinical course without any severe pain. Despite the fact that the presence of diffuse bone metastasis from gastric cancer plus hematologic disorders tends to indicate a significantly poor prognosis, the patient survived for a relatively long period (11 months) following chemotherapy. We thus conclude that MTX/5-FU sequential therapy seems to be a clinically useful regimen to improve both the symptoms and survival for cases of diffuse bone metastasis from gastric cancer.
Department of Gastroenterological Surgery, National Kyushu Cancer Center, Fukuoka, Japan.
T
T
Etoh
H
H
Baba
A
A
Taketomi
H
H
Nakashima
S
S
Kohnoe
Y
Y
Seo
T
T
Saito
H
H
Tomoda
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary*; D005472:Fluorouracil / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage*; D011877:Radionuclide Imaging; D013274:Stomach Neoplasms / Q000473:pathology*
D005472:Fluorouracil; D008727:Methotrexate