The role of H2-receptor antagonists in the pathogenesis of nosocomial pneumonia in mechanically ventilated patients.
We conducted a computerized MEDLINE search and selected controlled studies and meta-analyses correlating the frequency of nosocomial pneumonia (NP) with the administration of histamine2-receptor antagonists (H2RAs) as stress ulcer prophylaxis in critically ill patients. Although such a correlation does exist, the literature supports the theory that gastric bacterial overcolonization through alkalinization by H2RAs is not a risk factor for NP in critically ill patients. Further well-designed studies are necessary to resolve the issue and clarify the role of H2RAs in the pathogenesis of NP.
Department of Pharmacy Practice and Pharmacy Administration, Philadelphia College of Pharmacy and Science, Pennsylvania 19104, USA.
J
J
Trofe
A M
AM
Peterson
D003428:Cross Infection / Q000209:etiology*; D006635:Histamine H2 Antagonists / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D015201:Meta-Analysis as Topic; D011014:Pneumonia / Q000209:etiology*; D012121:Respiration, Artificial / Q000009:adverse effects*
D006635:Histamine H2 Antagonists