Inhibition of human immunodeficiency virus type 1 infection in SCID-hu Thy/Liv mice by the G-quartet-forming oligonucleotide, ISIS 5320.
Viral replication was inhibited in a dose-dependent manner after administration of the phosphorothioate oligonucleotide TTGGGGTT (ISIS 5320) to human immunodeficiency virus type 1 (HIV-1)-infected SCID-hu Thy/Liv mice. Potent in vivo antiviral activity was observed against the T-cell-tropic molecular clone NL4-3; the agent was found to have weak activity against one primary HIV-1 isolate, and the agent was inactive against a second primary isolate.
Stoddart
C A
CA
Gladstone Institute of Virology and Immunology, University of California, San Francisco, California, USA. cheryl_stoddart.givi@quickmail.ucsf.edu
Rabin
L
L
Hincenbergs
M
M
Moreno
M
M
Linquist-Stepps
V
V
Leeds
J M
JM
Truong
L A
LA
Wyatt
J R
JR
Ecker
D J
DJ
McCune
J M
JM
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy; D000818:Animals; D019380:Anti-HIV Agents / Q000494:pharmacology*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D051379:Mice; D016513:Mice, SCID; D009838:Oligodeoxyribonucleotides / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000637:transplantation; D013873:Thionucleotides / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects
D019380:Anti-HIV Agents; D009838:Oligodeoxyribonucleotides; D013873:Thionucleotides; C085909:oligonucleotide 5320