Tumor suppressor mutations in mice: the next generation.
Mouse strains carrying tumor suppressor mutations genetically mimic familial forms of human cancer. New tumor suppressors have and will be identified and mutated in the mouse; however, it is clear that future investigation will focus on a new generation of experiments aimed at improving existing models, and using them to delineate the molecular pathways to tumorigenesis and to test the value of rationally designed drug therapies.
Massachusetts General Hospital Cancer Center, Charlestown 02129, USA. mcclatch@helix.mgh.harvard.edu
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D000818:Animals; D004195:Disease Models, Animal; D005544:Forecasting; D016147:Genes, Tumor Suppressor / Q000235:genetics*; D006801:Humans; D051379:Mice; D009154:Mutation; D009374:Neoplasms, Experimental / Q000235:genetics; D012106:Research / Q000639:trends