Forty years of beta-lactam research.
For more than 40 years the author has been involved in research in the field of beta-lactam antibiotics. Much of this work was concerned with the development of the semisynthetic penicillins, following the isolation of the penicillin nucleus, 6-aminopenicillanic acid. This work resulted in the introduction of a number of important antibiotics including methicillin, cloxacillin, flucloxacillin, ampicillin, amoxycillin, carbenicillin and ticarcillin. Many of these compounds also provided the incentive or the basis for studies of a more fundamental nature in cell biology and antibacterial chemotherapy. The following is the author's personal account of some of the studies in the beta-lactam field in which he has been involved.
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Rolinson
D000818:Animals; D000900:Anti-Bacterial Agents / Q000266:history* / Q000494:pharmacology; D049673:History, 20th Century; D006801:Humans; D016106:Methicillin Resistance; D010406:Penicillins / Q000266:history; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects / Q000378:metabolism; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000378:metabolism; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D010406:Penicillins; D047090:beta-Lactams; D001618:beta-Lactamases