[Effects of sodium saccharin on the tracheal epithelium of mice].
The present study evaluated the effect of sodium saccharin on mouse tracheal epithelium, in relation to its possible structural alterations. Mice of the C3H strain were fed with standard pellets supplemented with sodium saccharin for 180 days. At that time the mice were sacrificed and their trachea were processed for transmission electronic microscopy. We demonstrated that sodium saccharin produces alterations in cellular surface cilia, with cytoplasmic excrescences and ciliary malformations. These results suggest that sodium saccharin is not an innocuous sweetener and that it may cause structural alterations in epithelial tissues.
Torres de Mercau
G
G
Departamento Biomédico, Facultad de Medicina, Universidad Nacional de Tucumán.
Riera de Martínez Villa
N
N
Vitalone
H
H
Mercau
G
G
Gamundi
S
S
Martínez Riera
N
N
Soria
N
N
D000818:Animals; D004848:Epithelium / Q000187:drug effects; D008297:Male; D051379:Mice; D012439:Saccharin / Q000494:pharmacology*; D014132:Trachea / Q000187:drug effects*
D012439:Saccharin