A variant Burkitt-type translocation (8;22)(q24;q11) in multiple myeloma. Report of a new case and review of the literature.
We report here a new case of multiple myeloma (IgG, kappa, stage IIIA) with a variant Burkitt-type translocation (8;22)(q24;q11). Bone marrow plasma cells were morphologically immature with fine nuclear chromatin and nucleoli. Chromosome analysis showed complex aberrations; that is, 53,XX, der(1)add(1)(p11)dup(1)(q12q32),+3,+5,t(8;22)(q24;q11),+9,add(10)( p13), +11,+15,add(19)(q13),+21. Fluorescence in situ hybridization analysis with the yeast artificial chromosome (YAC) clone I2 containing the C-MYC gene at 8q24 and the chromosome-22-specific DNA library pBS22 revealed that 12 was located on the der(8)t(8;22). A fusion signal derived from I2 and the YAC clone B99E1 containing the BCR gene at 22q11 was also observed on the der(8)t(8;22). Our results indicate that the breakpoint at 8q24 in this patient was located far downstream of the C-MYC gene. This breakpoint site is similar to Burkitt lymphoma with t(8;22)(q24;q11). A review of eight cases in the literature and the present case of multiple myeloma with t(8;22)(q24;q11) showed that most of them were of advanced stage and had an immature phenotype. It is suggested that the C-MYC gene may be activated by t(8;22)(q24;q11) and implicated in disease progression in multiple myeloma.
Department of Hematology, Musashino Red Cross Hospital, Tokyo, Japan.
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K
Yamamoto
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H
Hamaguchi
K
K
Nagata
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M
Taniwaki
D000328:Adult; D000368:Aged; D002051:Burkitt Lymphoma / Q000235:genetics; D018244:Chromosomes, Artificial, Yeast; D002892:Chromosomes, Human, Pair 22; D002898:Chromosomes, Human, Pair 8; D005260:Female; D016259:Genes, myc; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics*; D015513:Oncogene Proteins / Q000235:genetics; D011505:Protein-Tyrosine Kinases; D011518:Proto-Oncogene Proteins; D051562:Proto-Oncogene Proteins c-bcr; D014178:Translocation, Genetic
D015513:Oncogene Proteins; D011518:Proto-Oncogene Proteins; D011505:Protein-Tyrosine Kinases; C496613:BCR protein, human; D051562:Proto-Oncogene Proteins c-bcr