Cloning of human striatin cDNA (STRN), gene mapping to 2p22-p21, and preferential expression in brain.
Rat striatin, a recently discovered calmodulin-binding protein belonging to the WD repeat family, is expressed in neurons, mostly in the striatum and motor and olfactory systems. Striatin is localized in the somato-dendritic compartment of neurons, mainly in the spines. It may play a role in dendritic Ca2+ signaling. Here we report the cloning and sequencing of human striatin cDNA (HGMW-approved symbol STRN), the localization of the gene to chromosome 2p22-p21, and its preferential expression in brain. The human cDNA sequence is predicted to encode a 780-amino-acid protein possessing eight WD repeats. Striatin is highly conserved between rat and human with 96% identity and 98% similarity at the amino acid level. Since the Caenorabditis elegans genome also contains a closely related striatin coding sequence, the function of striatin is likely to be well conserved.
CNRS, 31 chemin Joseph Aiguier, Marseille Cedex 20, 13402, France.
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Moqrich
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Mattei
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Bartoli
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Rakitina
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Baillat
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Monneron
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Castets
D000595:Amino Acid Sequence; D000818:Animals; D002148:Calmodulin-Binding Proteins / Q000235:genetics*; D002490:Central Nervous System / Q000737:chemistry*; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D003001:Cloning, Molecular; D003342:Corpus Striatum / Q000737:chemistry; D018076:DNA, Complementary; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008565:Membrane Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009474:Neurons / Q000737:chemistry*; D051381:Rats; D017386:Sequence Homology, Amino Acid; D014018:Tissue Distribution
D002148:Calmodulin-Binding Proteins; D018076:DNA, Complementary; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; C491925:STRN protein, human; C114095:Strn protein, rat