Right and left ventricular interaction in ventricular fibrillation with mechanical maintenance of the circulation.
OBJECTIVE
To investigate the possible mechanisms of right and left ventricular interaction during ventricular fibrillation (VF) with mechanical maintenance of the circulation.


METHODS
In this experimental study, two para-aortic counterpulsation devices (PACDs) were implanted in 14 mongrel dogs.


METHODS
The PACD is a spheroid, valveless, with one opening, 100 ml stroke volume assisting device. After midsternotomy and pericardiotomy, two PACDs were implanted on the ascending aorta and the pulmonary artery, respectively. Catheters were placed into the aortic arch, and the left and right ventricles. An electromagnetic probe was placed on the descending aorta.


METHODS
After the completion of the experimental preparation, VF was induced and the two devices were synchronized and pumped simultaneously for 10 minutes (A). Subsequently, the left sided PACD pumped alone for the same period of time (B). This sequence was repeated 1-10 times in each experiment.


METHODS
The aortic pressures, the left and right ventricular pressures and the cardiac index were obtained at the end of each intervention.


RESULTS
The simultaneous pumping of the two devices (A) compared with the pumping of that implanted on the ascending aorta (B) resulted in: higher peak aortic pressure 119.1+/-32.1 mmHg (A) vs 105.7+/-36.4 mmHg (B), p<0.001, mean aortic pressure 42.1+/-13.2 mmHg vs 27.8+/-10.5 mmHg, p<0.001, mean left ventricular pressure 18.4+4.0 mmHg vs 11.7+/-3.6 mmHg, p<0.001, and cardiac index 105.7+/-40.1 ml/kg/min vs 82.0+/-39.9 ml/kg/mm, p<0.001, and lower right ventricular pressure 10.1+/-3.2 mmHg vs 13.3+/-2.6 mmHg, p<0.001.


CONCLUSIONS
Maintenance of the circulation during VF with the PACD implanted on the ascending aorta results in equalization of the right and left ventricular pressures. In contrast, when both devices are pumping simultaneously, the left ventricular pressure is significantly higher than the right one and the assistance is more effective.
Department of Clinical Therapeutics, University of Athens, Medical School, Greece.
C E
CE
Charitos
J N
JN
Nanas
S N
SN
Nanas
I
I
Chatzigeorgiou
N
N
Alevizakos
K
K
Cosmas
S D
SD
Moulopoulos
D000818:Animals; D001011:Aorta / Q000502:physiology; D001794:Blood Pressure; D003326:Coronary Circulation / Q000502:physiology*; D015908:Counterpulsation; D004285:Dogs; D006353:Heart-Assist Devices; D006439:Hemodynamics; D014693:Ventricular Fibrillation / Q000503:physiopathology*; D017725:Ventricular Pressure / Q000502:physiology*