Cytotoxic 2,3-secoaromadendrane-type sesquiterpenoids from the liverwort Plagiochila ovalifolia.
The ether extract of the Japanese liverwort, Plagiochila ovalifolia Mitt. (Plagiochilaceae) yielded three 2,3-secoaromadendrane-type sesquiterpenoids, plagiochiline-A-15-yl octanoate, 14-hydroxyplagiochiline-A-15-yl 2E,4E-dodecadienoate and 14-hydroxyplagiochiline-A-15-yl 2E,4E,8Z-tetradecatrienoate. The two latter compounds were first isolated from the Plagiochila species. The structures of the new compounds were elucidated by spectroscopy. Plagiochiline-A-15-yl octanoate and 14-hydroxyplagiochiline-A-15-yl 2E,4E-dodecadienoate showed significant cytotoxicity against P-388 murine leukemia tumor cells, both compounds exhibiting an ID50 of 0.05 microgram/ml. Plagiochiline A also showed cytotoxic activity. The ID50 was 3.0 micrograms/ml.
M
M
Toyota
K
K
Tanimura
Y
Y
Asakawa
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051379:Mice; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013057:Spectrum Analysis
D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes