Immunological analysis of epitopes on hCG.
The heterodimeric glycoprotein hormone, human chorionic gonadotropin, has been extensively characterized in terms of its recognition by mouse monoclonal antibodies. A number of different approaches have led to the definition of several epitope clusters on the surface of the molecule. These include epitopes located solely on the alpha- or beta-chain, some of which are masked when the two chains associate to form the holo-hormone. Additional epitopes comprise amino acids contributed by both the chains. In contrast to the extensive knowledge regarding B cell epitopes, the characterization of T cell epitopes on hCG has only recently begun to be explored.
Department of Immunology, Windeyer Institute for Medical Sciences, UCL Medical School, London, UK.
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D000818:Animals; D000911:Antibodies, Monoclonal; D001402:B-Lymphocytes / Q000276:immunology; D006063:Chorionic Gonadotropin / Q000737:chemistry / Q000276:immunology*; D000939:Epitopes / Q000032:analysis* / Q000737:chemistry; D006801:Humans; D051379:Mice; D008958:Models, Molecular; D013601:T-Lymphocytes / Q000276:immunology
D000911:Antibodies, Monoclonal; D006063:Chorionic Gonadotropin; D000939:Epitopes