Glutathione based approaches to improving cancer treatment.
The use of cytotoxic chemotherapy for cancer therapy has been very successful in the treatment and often cure of patients with particular neoplasms, such as testicular carcinomas and some lymphomas. In addition, the use of adjuvant chemotherapy in patients whose primary tumor has been surgically removed contributes significantly to cure rates in some of the more common malignancies such as breast carcinoma and colon cancer. Nonetheless, for most patients with metastatic malignancies, current antineoplastic drugs provide only brief remissions with few or no long term cures. In addition, the side effects of therapy lead to substantial morbidity in nearly all patients. Insights derived from model system studies on two glutathione based lead compounds, TER286 and TER199, suggest new clinical strategies and raise interesting basic research questions regarding the cell biology foundations of cancer chemotherapy.
Kauvar
L M
LM
Terrapin Technologies, San Francisco, CA 94080, USA.
Morgan
A S
AS
Sanderson
P E
PE
Henner
W D
WD
D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000627:therapeutic use; D001711:Biotransformation; D003603:Cytotoxins / Q000493:pharmacokinetics / Q000627:therapeutic use; D004351:Drug Resistance; D004791:Enzyme Inhibitors / Q000493:pharmacokinetics / Q000627:therapeutic use; D005260:Female; D005978:Glutathione / Q000031:analogs & derivatives / Q000378:metabolism* / Q000493:pharmacokinetics / Q000627:therapeutic use; D005982:Glutathione Transferase / Q000037:antagonists & inhibitors; D006410:Hematopoiesis / Q000187:drug effects; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism*
D000970:Antineoplastic Agents; D003603:Cytotoxins; D004791:Enzyme Inhibitors; C096329:gamma-Glu-S-BzCys-PhGly diethyl ester; C107479:TER 286; D005982:Glutathione Transferase; D005978:Glutathione