Thyroid dosimetry of adult European populations.
Radioactive iodine, in the form of iodine-131, behaves similarly to stable iodine in small quantities, thus resulting in a radiation dose to the thyroid. Under the Medical Internal Radiation Dosimetry Committee formulation for radiation dose calculation to an organ, the resulting dose to the thyroid gland is dependent on the organ mass, its isotope uptake and the effective half-life of the element in the gland. Traditionally, values have been used for these parameters which, in some cases, were determined some decades previous. Iodine supply is a primary contributor to correct thyroid function and ultimately these values of mass, uptake and half-life. Recently, new data have become available on iodine kinetics throughout Europe. Here, the influence of the highly variable iodine supply in Europe on projected thyroid doses is determined. Thyroid mass values ranged from 9 g (Sweden) to 28 g (Poland) while uptake measurements were found to range from 18% (Finland) to approximately 60% (Germany and Poland). Resulting dose estimates ranged from 0.5 Gy MBq-1 (Finland) injested to 1.3 Gy MBq-1 (Czechoslovakia) injested. It was also found that among European populations the highest dose burden was to those populations with mild iodine deficiency. The results show that the use of generic metabolic data for the thyroid can lead to a misrepresentation of the absorbed dose to the thyroid. Thus, the data presented provide a better reflection of the actual thyroid dose following ingestion of iodine-131 for European countries.
Medical Physics and Bioengineering Department, St James's Hospital, Dublin, Ireland.
N J
NJ
O'Hare
D
D
Murphy
J F
JF
Malone
D000328:Adult; D001417:Background Radiation; D004781:Environmental Exposure; D005060:Europe; D006207:Half-Life; D006801:Humans; D007455:Iodine / Q000172:deficiency; D007457:Iodine Radioisotopes / Q000008:administration & dosage* / Q000493:pharmacokinetics; D011829:Radiation Dosage; D011874:Radiometry; D013961:Thyroid Gland / Q000033:anatomy & histology / Q000378:metabolism / Q000528:radiation effects*
D007457:Iodine Radioisotopes; D007455:Iodine