[Pressure-reducing effect of latanoprost 0.005%].
BACKGROUND
Earlier studies in monkeys have shown that latanoprost 0.005% lowers the IOP by improving the uveoscleral Outflow. We wanted to know if this is also the case in the human eye.


METHODS
We used our new aqueous humor outflow test with 2-nitrophenyl-acetate in 9 healthy human volunteers, mean age 32 +/- 8.3 years. They were measured before and 12 h after receiving one drop of latanoprost 0.005% in one eye, randomly chosen. The ocular Photometer was used to quantify the disappearance of the dye out of the anterior chamber.


RESULTS
The half-life time of the dye is shortened after latanoprost 0.005%. It is significantly correlated to the pressure lowering effect of latanoprost 0.005% (r2 = 0.5968).


CONCLUSIONS
The dye-dilution technique proves that latanoprost 0.005% influences the outflow of the human eye. The better the outflow, the greater the pressure drop in the eye. The experiment nicely shows that photometric quantification of 2-nitrophenyl-acetate is a simple, reliable test for the knowledge of the aqueous humor outflow.
Universitätsaugenklinik, Frauenklinikstrasse 24 Nord II, Zürich.
C
C
Albach
E D
ED
Wachsmuth
K
K
Velte
P
P
Dekker
Y
Y
Robert
D000328:Adult; D001082:Aqueous Humor / Q000187:drug effects; D004395:Dye Dilution Technique; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D000077338:Latanoprost; D008297:Male; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology*; D012016:Reference Values
D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost