Cutaneous reactivity of the hands in nickel-sensitive patients with hand eczema.
This study compares the cutaneous reactivity between the hand and the back for 7 female patients with active hand eczema, who were found to be nickel-sensitive on routine patch testing with the European standard series. Patients were patch tested to a dilution series of nickel sulfate on the back in order to determine the threshold concentration for elicitation of allergic contact dermatitis, and based upon this result a lower concentration of nickel was then used for patch tests on the hand. We found that in the majority of patients (6/7) the cutaneous responsiveness of the hand was not increased compared with that of the back. However, the hand of 1 patient was more sensitive to nickel and patch testing was accompanied with a flare of her eczema, which suggests that cutaneous hyperreactivity may be important in individual patients with hand eczema.
Stoke Mandeville Hospital, Aylesbury, Bucks, UK.
C C
CC
Banfield
D A
DA
Basketter
S M
SM
Powell
D000293:Adolescent; D000328:Adult; D000368:Aged; D001415:Back; D017449:Dermatitis, Allergic Contact / Q000209:etiology / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004485:Eczema / Q000503:physiopathology*; D005260:Female; D006229:Hand Dermatoses / Q000503:physiopathology*; D006801:Humans; D008875:Middle Aged; D009532:Nickel / Q000008:administration & dosage / Q000009:adverse effects*; D010328:Patch Tests; D012720:Severity of Illness Index; D012867:Skin / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology
D009532:Nickel