Differential splicing of type II procollagen mRNA in canine retina.
Canine retina expressed two forms of Type II procollagen mRNA, IIA and IIB, due to alternate splicing of exon 2 at the N-propeptide region. The N-propeptide region of Type II procollagen showed a high degree of homology with human, approximately 96% both at the nucleotide and the amino acid levels. Expression of IIA and IIB forms of Type II procollagen from early stage of development to adult life suggests the important role of both forms for the development as well as maintenance of the ocular structure.
James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA.
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D017398:Alternative Splicing; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D017124:Conserved Sequence; D018076:DNA, Complementary / Q000737:chemistry; D004285:Dogs / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D011347:Procollagen / Q000737:chemistry / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012160:Retina / Q000378:metabolism*; D017385:Sequence Homology
D018076:DNA, Complementary; D011347:Procollagen; D012333:RNA, Messenger