Effects of long-term contact lens wear on the corneal endothelium.
OBJECTIVE
To analyze the long-term effects of soft and hard (PMMA) contact lenses (CL) on the human corneal endothelium.


METHODS
One hundred and one contact lens wearers with > or =10 years' wearing time and 50 healthy control subjects were examined with specular microscope.


RESULTS
The mean corneal endothelial cell densities of the CL wearers (2846 cells/mm2) and of the control eyes (2940 cells/mm2) differed by 94 cells/mm2 (p<0.05). The mean values for the coefficient of variation (CV) differed significantly (p<0.0001); for all CL wearers: mean CV=0.31, vs. for controls: 0.22. The mean endothelial cell density of the eyes exposed to CL wear for more than 25 years (30 eyes) was 2575 cells/mm2 (mean CV: 0.36). Rather low densities (<2000 cells/mm2) were observed in 16 eyes of the CL group (8%). Cell densities less than 2500 cells/mm2 were observed in a total of 41 eyes (20%) in the CL group, whereas in the control group (100 eyes) all of the subjects, except one, had cell densities of more than 2500 cells/mm2 in both eyes.


CONCLUSIONS
A subgroup of PMMA as well as soft contact lens wearers react not only with high pleomorphism and polymegethism but also with a decrease in endothelial cell density.
Setälä
K
K
Department of Ophthalmology, Helsinki University Central Hospital, Finland.
Vasara
K
K
Vesti
E
E
Ruusuvaara
P
P
D000328:Adult; D000368:Aged; D002452:Cell Count; D003263:Contact Lenses, Hydrophilic / Q000009:adverse effects* / Q000706:statistics & numerical data; D003316:Corneal Diseases / Q000209:etiology* / Q000473:pathology; D004728:Endothelium, Corneal / Q000473:pathology*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D019904:Polymethyl Methacrylate / Q000009:adverse effects*; D019736:Prostheses and Implants / Q000706:statistics & numerical data*
D019904:Polymethyl Methacrylate