Properties of natural animal gamma-interferons and peculiarities of their action.
According to new biotechnology natural gamma-IFNs of swine and cattle as well as of laboratory animals (rabbits, rats, mice) were obtained. By trials in vitro and in vivo the preparations of swine and cattle gamma-IFNs have been tested. It was shown, that in vitro and in vivo functional activity of phagocytes (monocytes and neutrophils) sharply increased. There were increased phagocytic number, phagocytic index, bactericidal action, including functional reserve, the difference between spontaneous and stimulated by Staphylococcus antigen levels of bactericidity. Additional treatment by gamma-IFNs of animals after immunization by colibacteriosis vaccine increased antibody genesis 3-8 times in comparison with the control, but these titers were more stable during two months after revaccination. Besides antiviral activity, preparations of these gamma-IFNs had antibactericidal and antitoxic action of wide spectrum of specificity. The studied preparations are perspective means at usage in infectious pathology of animals, leukoses, immunodeficiencies.
Institute of Microbiology and Virology, National Academy of Science of Ukraine, Kyiv.
Ia H
IaH
Kishko
M I
MI
Vasylenko
D000818:Animals; D000831:Animals, Newborn; D000907:Antibodies, Bacterial / Q000096:biosynthesis / Q000187:drug effects; D001428:Bacterial Vaccines / Q000276:immunology; D001770:Blood Bactericidal Activity / Q000187:drug effects; D002417:Cattle; D004926:Escherichia coli / Q000276:immunology; D007111:Immunity, Cellular / Q000187:drug effects; D007114:Immunization; D007371:Interferon-gamma / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D010586:Phagocytes / Q000187:drug effects / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D013552:Swine; D013997:Time Factors
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D007371:Interferon-gamma