Transition-metal-mediated reactions in combinatorial synthesis.
Transition-metal-mediated reactions have played an important role in expanding the scope of combinatorial chemistry from synthesis of peptidic libraries to synthesis of nonoligomeric, small-molecule libraries. Versatile reactions such as heteroannulations, olefin metathesis and dipolar cycloadditions are used for preparation of libraries of historical, as well as novel, pharmacophores. Transition-metal-mediated reactions have also been used strategically to provide traceless linkers' in solid-phase synthesis.
Andres
C J
CJ
Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06443, USA.
Whitehouse
D L
DL
Deshpande
M S
MS
D000475:Alkenes; D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D015195:Drug Design; D007202:Indicators and Reagents; D008670:Metals
D000475:Alkenes; D007202:Indicators and Reagents; D008670:Metals