Comparative in vitro activity of BAY 12-8039 and five other antimicrobial agents against anaerobic bacteria.
The in vitro activity of BAY 12-8039 against 360 anaerobic clinical isolates was determined by the agar dilution method and compared to that of five other antimicrobial agents. BAY 12-8039 and imipenem were the most active agents tested. The following MIC90 values were determined for BAY 12-8039: Peptostreptococcus spp. (50 isolates), 1 mg/l; Propionibacterium acnes (30 isolates). 0.25 mg/l; Clostridium perfringens (30 isolates), 0.5 mg/l; Clostridium difficile (50 isolates), 2 mg/l; Bacteroides fragilis (50 isolates), 1 mg/l; non-fragilis Bacteroides, Porphyromonas, and Prevotella spp. (100 isolates), 2 mg/l; and Fusobacterium spp. (50 isolates), 0.25 mg/l. The results of the present study show that BAY 12-8039 may be useful in the treatment and prophylaxis of anaerobic infections.
Department of Immunology, Microbiology, Pathology and Infectious Diseases, Huddinge University Hospital, Karolinska Institute, Sweden.
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Edlund
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Sabouri
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Nord
D000890:Anti-Infective Agents / Q000494:pharmacology*; D001372:Aza Compounds; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D002440:Cefoxitin / Q000494:pharmacology; D002513:Cephamycins / Q000494:pharmacology; D002981:Clindamycin / Q000494:pharmacology; D024841:Fluoroquinolones; D015378:Imipenem / Q000494:pharmacology; D008795:Metronidazole / Q000494:pharmacology; D000077266:Moxifloxacin; D015242:Ofloxacin / Q000494:pharmacology; D011804:Quinolines; D015363:Quinolones / Q000494:pharmacology*; D013845:Thienamycins / Q000494:pharmacology
D000890:Anti-Infective Agents; D001372:Aza Compounds; D002513:Cephamycins; D024841:Fluoroquinolones; D011804:Quinolines; D015363:Quinolones; D013845:Thienamycins; D008795:Metronidazole; D002981:Clindamycin; D002440:Cefoxitin; D015378:Imipenem; D015242:Ofloxacin; D000077266:Moxifloxacin