Antitumor properties of boron complexes with hydroxy biguanide and salicyl hydroxamic acid against Ehrlich ascites carcinoma.
A new derivative of hydroxamic acid, hydroxy biguanido hydrochloride monohydrate and its boron derivative, dihydroxy-oxybiguanido boron (III) hydrochloride monohydrate were synthesized. Another boron compound, hydroxo-salicyl-hydroxamato boron (III) was synthesized from known salicyl hydroxamic acid. Antitumor properties of all the compounds evaluated against Ehrlich ascites carcinoma in mice show enhanced survival time when boron is incorporated in the compounds. Hematological parameters, alkaline phosphatase in serum of the treated animals show minimum toxic effects after boron is coupled with their respective hydroxamic acids.
Ghosh
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Department of Chemistry, Jadavpur University, Calcutta, India.
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D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000633:toxicity; D001645:Biguanides / Q000494:pharmacology* / Q000633:toxicity; D001896:Boron Compounds / Q000494:pharmacology* / Q000633:toxicity; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D007928:Lethal Dose 50; D051379:Mice; D008805:Mice, Inbred A; D012457:Salicylamides / Q000494:pharmacology* / Q000633:toxicity
D000970:Antineoplastic Agents; D001645:Biguanides; D001896:Boron Compounds; D012457:Salicylamides; C005703:salicylhydroxamic acid