Resynchronisation of a diurnal rodent circadian clock accelerated by a melatonin agonist.
Using 'jet lag' paradigms involving phase shifts in the light-dark (LD) cycle, we studied the effects of S-20098 on the circadian clock of a diurnal rodent. Arvicanthis mordax, entrained to a regular LD cycle, were subjected to advance shifts (i.e. 4, 6 or 8 h) in the LD cycle and injected with vehicle or the melatonin agonist S-20098 (20 mg/kg) the day of the shift (and also on subsequent days in the 6 h or 8 h shift paradigms). In each condition, S-20098 accelerated by about 30% resynchronization to the new LD cycle. These data, which are the first to demonstrate the chronobiotic effects of a melatonin agonist in a diurnal rodent, provide new insights for the design of human chronopharmacological protocols.
Centre d'Etude des Rythmes Biologiques, Faculté de Médecine, Université Libre de Bruxelles, Hôpital Erasme, Brussels, Belgium.
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Van Reeth
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Olivares
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Turek
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Granjon
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Mocaer
D000081:Acetamides / Q000494:pharmacology*; D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D003624:Darkness; D006801:Humans; D008027:Light; D008297:Male; D008550:Melatonin / Q000819:agonists*; D008954:Models, Biological; D009115:Muridae / Q000502:physiology*; D014195:Travel; D009281:Naphthalenes
D000081:Acetamides; D008550:Melatonin; C084711:agomelatine; D009281:Naphthalenes