Erythematous bullous lesions on the dorsa of the hands due to contact exposure to ibutilide fumarate for injection.
While waiting to observe the response to ibutilide fumarate by a patient with atrial fibrillation, a nurse preparing the intravenous solution inadvertently spilled the drug on the hands of a medical resident. The resident immediately wiped his hands dry with disposable paper towels. Several hours later he sensed tingling and itching over the area, and the next day two erythematous bullous lesions were present on the dorsal surfaces of both hands. A single application of topical steroid was applied to the affected areas. The lesions were kept clean and dry, and healed completely in approximately 10 days. This is an unusual allergic reaction due to contact with ibutilide fumarate.
Department of Pharmacy Practice, Bouvé College of Pharmacy and Health Sciences, Northeastern University, Boston, Massachusetts 02115, USA.
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D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D004868:Equipment Failure; D004890:Erythema / Q000139:chemically induced*; D006229:Hand Dermatoses / Q000139:chemically induced*; D006801:Humans; D007260:Infusion Pumps; D008297:Male; D016273:Occupational Exposure / Q000009:adverse effects*; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced*; D013449:Sulfonamides / Q000009:adverse effects*
D000889:Anti-Arrhythmia Agents; D013449:Sulfonamides; C067192:ibutilide