Production of gastroesophageal erosions and ulcers (GEU) in gnotobiotic swine monoinfected with fermentative commensal bacteria and fed high-carbohydrate diet.
Erosions and gastroesophageal ulcers (GEU) were produced in the pars esophagea of young gnotobiotic swine fed a carbohydrate-enriched liquid diet and monoinfected with two different fermentative commensal bacteria, Lactobacillus and Bacillus sp. In contrast, piglets, fed a similar diet and inoculated with Gastrospirillum sp. (Helicobacter heilmannii), a helicobacter species that colonizes the gastric mucosa, did not develop GEU. Experimental GEU likely develops secondary to epithelial damage mediated by microbial-origin acids whose production is potentiated by high dietary carbohydrate and parietal cell-origin hydrochloric acid.
Department of Veterinary Biosciences, College of Veterinary Medicine, Ohio State University, Columbus 43210, USA.
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D000818:Animals; D001407:Bacillus / Q000302:isolation & purification / Q000472:pathogenicity*; D002455:Cell Division; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D004848:Epithelium / Q000382:microbiology / Q000473:pathology; D004935:Esophageal Diseases / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D004943:Esophagogastric Junction / Q000382:microbiology* / Q000473:pathology; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology; D005856:Germ-Free Life; D016998:Helicobacter / Q000302:isolation & purification / Q000472:pathogenicity; D006863:Hydrogen-Ion Concentration; D007778:Lactobacillus / Q000302:isolation & purification / Q000472:pathogenicity*; D013276:Stomach Ulcer / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000382:microbiology* / Q000473:pathology
D004040:Dietary Carbohydrates