Association of neuropsychological vulnerability markers in relatives of schizophrenic patients.
We investigated the association of neuropsychological risk indicators in a matched sample of first-degree relatives of schizophrenic patients (n = 54) and normal controls (n = 72). We focussed on three functions previously identified in a smaller, initial sample as putative risk indicators of the schizophrenia genotype: abstraction, verbal memory and auditory attention. The expanded sample of relatives displayed significantly lower scores than controls on abstraction, verbal memory and auditory attention. The relatives demonstrated significant intercorrelations among these three functions. The significant correlations among relatives between attention and verbal memory and between attention and abstraction differed significantly from these correlations among controls. We discuss how the use of multiple risk indicators may help us better identify those relatives that carry the schizophrenia genotype.
Toomey
R
R
Harvard Institute of Psychiatric Epidemiology and Genetics, Boston, MA, USA. rtoomey@warren.med.harvard.edu
Faraone
S V
SV
Seidman
L J
LJ
Kremen
W S
WS
Pepple
J R
JR
Tsuang
M T
MT
D000328:Adult; D001288:Attention / Q000502:physiology; D015415:Biomarkers; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003072:Cognition Disorders / Q000235:genetics*; D003210:Concept Formation / Q000502:physiology; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008569:Memory Disorders / Q000235:genetics; D009483:Neuropsychological Tests; D012559:Schizophrenia / Q000235:genetics*; D012565:Schizophrenic Psychology; D014705:Verbal Behavior / Q000502:physiology
D015415:Biomarkers