Licochalcone A: an inducer of cell differentiation and cytotoxic agent from Pogostemon cablin.
Licochalcone A (1), ombuin (2), and 5,7-dihydroxy-3',4'-dimethoxyflavanone (3) were isolated from the aerial parts of Pogostemon cablin by cytotoxicity-guided fractionation. Compound 1 showed in vitro cytotoxicity and Pl-PLC gamma 1 inhibition activity. Treatment of promyelocytic leukemia cells (HL-60) with compound 1 induced terminal differentiation with the generation of monocyte using nonspecific acid esterase assay.
E J
EJ
Park
H R
HR
Park
J S
JS
Lee
J
J
Kim
D016475:3T3 Cells; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects*; D002599:Chalcone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D047188:Chalcones; D004791:Enzyme Inhibitors / Q000494:pharmacology; D007887:Fabaceae / Q000737:chemistry*; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D043265:Phosphatidylinositol Diacylglycerol-Lyase; D010946:Plants, Medicinal / Q000737:chemistry*; D013057:Spectrum Analysis; D014407:Tumor Cells, Cultured; D010738:Type C Phospholipases / Q000037:antagonists & inhibitors
D000972:Antineoplastic Agents, Phytogenic; D047188:Chalcones; D004791:Enzyme Inhibitors; D002599:Chalcone; D010738:Type C Phospholipases; D043265:Phosphatidylinositol Diacylglycerol-Lyase; C070840:licochalcone A