Methamphetamine-induced Fos expression in the substantia nigra pars reticulata in rats with a unilateral 6-OHDA lesion of the nigrostriatal fibers.
In rats with a unilateral 6-hydroxydopamine (6-OHDA)-induced lesion in the nigrostriatal fibers, methamphetamine (3 mg/kg, i.p.) induced Fos-like immunoreactivity (FLI), which was inhibited by pretreatment with N-methyl-D-aspartate antagonist MK-801 (1 mg/kg, i.p.), not only in the medial striatum contralateral to the lesion but also in the substantia nigra pars reticulata (SNr) ipsilateral to the lesion. Thus, hemispheric asymmetries in FLI were induced by methamphetamine in the medial striatum and the SNr in the 6-OHDA model of turning which may be related to the altered function of glutamatergic transmission.
Department of Psychiatry, Miyazaki Medical College, Japan. ishiday@post.miyazaki-med.ac.jp
Y
Y
Ishida
K
K
Todaka
I
I
Kuwahara
H
H
Nakane
Y
Y
Ishizuka
T
T
Nishimori
Y
Y
Mitsuyama
D000818:Animals; D016291:Dizocilpine Maleate / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D005260:Female; D008694:Methamphetamine / Q000494:pharmacology*; D009412:Nerve Fibers / Q000737:chemistry / Q000187:drug effects / Q000201:enzymology; D016627:Oxidopamine; D016760:Proto-Oncogene Proteins c-fos / Q000032:analysis / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D013378:Substantia Nigra / Q000737:chemistry / Q000378:metabolism*; D013565:Sympatholytics; D013566:Sympathomimetics / Q000494:pharmacology*; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis
D018691:Excitatory Amino Acid Antagonists; D016760:Proto-Oncogene Proteins c-fos; D013565:Sympatholytics; D013566:Sympathomimetics; D008694:Methamphetamine; D016291:Dizocilpine Maleate; D016627:Oxidopamine; D014446:Tyrosine 3-Monooxygenase