Pharmacokinetics of ifosfamide and some metabolites in children.
The pharmacokinetics of ifosfamide and some metabolites in children was investigated. The patients received various doses of ifosfamide, mostly by continuous infusion, over several days. The penetration of ifosfamide and its metabolites into the cerebrospinal fluid was also studied in four cases. Ifosfamide and 4-hydroxyifosfamide pass the blood-brain barrier, reaching cerebrospinal fluid concentrations that are almost as high as plasma concentrations.
Department of Pharmaceutical Analysis, Faculty of Pharmacy, Utrecht University, The Netherlands.
G P
GP
Kaijser
J
J
De Kraker
A
A
Bult
W J
WJ
Underberg
J H
JH
Beijnen
D000293:Adolescent; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics*; D002648:Child; D003520:Cyclophosphamide / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000134:cerebrospinal fluid / Q000378:metabolism / Q000493:pharmacokinetics*; D008297:Male; D013997:Time Factors
D018906:Antineoplastic Agents, Alkylating; C064445:dechloroethylcyclophosphamide; D003520:Cyclophosphamide; C039771:4-hydroxyifosfamide; C038007:dechloroethylifosfamide; D007069:Ifosfamide