Budesonide in the treatment of collagenous colitis.
Collagenous colitis is characterized by watery diarrhea and inflammatory infiltration associated with a subepithelial collagen deposit on colonic biopsies despite a normal or subnormal endoscopic appearance. We here describe 5 patients treated with the locally active steroid budesonide. Complete and partial response was observed in 3 and 2 patients, respectively. Budesonide thus seems to be of therapeutic benefit in collagenous colitis. Prospective randomized long-term studies are needed to support this hypothesis.
Division of Gastroenterology and Hepatology, University Hospital, Lausanne, Switzerland. Joakim.Delarive@hospvd.ch
J
J
Delarive
E
E
Saraga
G
G
Dorta
A
A
Blum
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001706:Biopsy; D019819:Budesonide / Q000627:therapeutic use*; D003092:Colitis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D003094:Collagen / Q000378:metabolism*; D003095:Collagen Diseases / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D003106:Colon / Q000378:metabolism / Q000473:pathology; D003113:Colonoscopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged
D000893:Anti-Inflammatory Agents; D019819:Budesonide; D003094:Collagen