[Prophylactic effect of nicorandil on perioperative coronary spasm].
The prophylactic effect of nicorandil on perioperative coronary spasm (CS) in CABG was examined retrospectively. The subjects were 313 patients who had undergone elective CABG. The patients were divided into two groups a control group receiving single administration of nitroglycerine (N = 196) and a nicorandil group receiving both nitroglycerine and nicorandil (4 mg.h-1-8 mg.h-1) (N = 107). The two groups were compared. The incidence of CS was 14 cases (7.1%) in the control group and 6 cases (5.6%) in the nicorandil group, demonstrating a significant difference. With the dose and the administration method employed in this study, no prophylactic effect of nicorandil on perioperative CS has been demonstrated.
Department of Anesthesiology, Kanagawa Cardiovascular and Respiratory Center, Yokohama.
Y
Y
Hirose
M
M
Gamo
M
M
Hirose
M
M
Harigae
C
C
Fujiwara
D001026:Coronary Artery Bypass; D003329:Coronary Vasospasm / Q000517:prevention & control*; D017558:Elective Surgical Procedures; D006801:Humans; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000627:therapeutic use; D020108:Nicorandil; D019990:Perioperative Care; D012189:Retrospective Studies; D014665:Vasodilator Agents / Q000627:therapeutic use*
D014665:Vasodilator Agents; D009536:Niacinamide; D020108:Nicorandil