Disruption in prepulse inhibition after alpha-1 adrenoceptor stimulation in rats.
The role of the alpha-1 adrenoceptor in prepulse inhibition (PPI) was evaluated in rats. The alpha-1 adrenergic agonist cirazoline disrupted PPI; this effect was reversed by the alpha-1 adrenergic antagonist prazosin or the atypical antipsychotic quetiapine. Alpha-1 adrenoceptors may thus be involved in the regulation of PPI and in the psychotherapeutic actions of certain antipsychotics.
Department of Neurosciences, University of California at San Diego, La Jolla 92093-0804, USA.
B S
BS
Carasso
V P
VP
Bakshi
M A
MA
Geyer
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D003987:Dibenzothiazepines / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D011224:Prazosin / Q000494:pharmacology; D000069348:Quetiapine Fumarate; D020891:Raclopride; D051381:Rats; D017207:Rats, Sprague-Dawley; D018340:Receptors, Adrenergic, alpha-1 / Q000187:drug effects* / Q000502:physiology; D013216:Reflex, Startle / Q000187:drug effects* / Q000502:physiology; D012457:Salicylamides / Q000494:pharmacology
D000316:Adrenergic alpha-Agonists; D003987:Dibenzothiazepines; D018492:Dopamine Antagonists; D007093:Imidazoles; D018340:Receptors, Adrenergic, alpha-1; D012457:Salicylamides; D000069348:Quetiapine Fumarate; D020891:Raclopride; C014282:cirazoline; D011224:Prazosin