High levels of macrophage inflammatory protein-1alpha correlate with prolactin in female patients with active rheumatoid arthritis.
The relationship between the endocrine immune modulator prolactin and the macrophage activation parameter MIP-1alpha (macrophage inflammatory protein-1alpha) was investigated in 61 females with rheumatoid arthritis (RA). The chemokine MIP-1alpha was found to be twice as high in active than in inactive RA. Parallel to the inflammatory activity (acute phase response and joint count) and high levels of MIP-1alpha there were markable changes of serum prolactin. MIP-1alpha seems to have an influence on the pituitary hormone secretion. A significant correlation between prolactin and MIP-1alpha (r = 0.67; p < or = 0.00001) point out the bidirectional influence of the immune and endocrine system in RA.
Ludwig Boltzmann Institute for Rehabilitation of Internal Diseases, Saalfelden, Austria.
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Kullich
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Klein
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood*; D001327:Autoimmune Diseases / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D054405:Chemokine CCL3; D054407:Chemokine CCL4; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D019402:Macrophage Inflammatory Proteins / Q000097:blood*; D008875:Middle Aged; D011388:Prolactin / Q000097:blood*; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
D015415:Biomarkers; D054405:Chemokine CCL3; D054407:Chemokine CCL4; D019402:Macrophage Inflammatory Proteins; D011388:Prolactin