Rapid chylomicron appearance following sequential meals: effects of second meal composition.
Previous studies have noted the presence of an early postprandial peak in plasma triacylglycerol concentrations following successive fat-rich meals. An earlier study has shown that the triacylglycerol in this early peak originates from a previous meal. The present study was performed to investigate the effects of different second meals on the plasma triacylglycerol response. Six healthy subjects were studied on four occasions each. At 5 h following a fat-rich breakfast they ingested one of the following in a balanced design: a fat-rich meal, a low-fat meal, water or nothing by mouth. Blood samples were taken for 2.5 h following the second meal. An early peak in chylomicron and plasma triacylglycerol concentrations was seen following both low-fat and fat-rich second meals but not following water. During studies investigating postprandial lipaemia, further meals must be avoided, even if they contain no fat, although water may be allowed.
Evans
K
K
Nuffield Department of Clinical Biochemistry, John Radcliffe Hospital, Headington, Oxford, UK.
Kuusela
P J
PJ
Cruz
M L
ML
Wilhelmova
I
I
Fielding
B A
BA
Frayn
K N
KN
D000328:Adult; D000704:Analysis of Variance; D002914:Chylomicrons / Q000097:blood*; D004041:Dietary Fats / Q000008:administration & dosage*; D004326:Drinking; D004435:Eating / Q000502:physiology*; D006801:Humans; D008297:Male; D019518:Postprandial Period; D014280:Triglycerides / Q000032:analysis / Q000378:metabolism*
D002914:Chylomicrons; D004041:Dietary Fats; D014280:Triglycerides