Multiple solid-phase synthesis of hydantoins and thiohydantoins.
A novel general protocol for the construction of hydantoins and thiohydantoins on a solid support has been developed. Using this novel methodology, the synthesis of a diverse 96-compound library has been achieved. Resin-bound dipeptides are cyclised via the formation of an intermediate isocyanate or isothiocyanate on resin as the key step in the strategy.
Oxford Diversity, Division of Oxford Asymmetry Ltd., Abingdon, Oxon, UK.
G
G
Bhalay
D
D
Cowell
N D
ND
Hone
M
M
Scobie
A D
AD
Baxter
D016208:Databases, Factual; D006827:Hydantoins / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D013058:Mass Spectrometry; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012116:Resins, Plant; D013329:Structure-Activity Relationship; D013867:Thiohydantoins / Q000138:chemical synthesis* / Q000737:chemistry
D006827:Hydantoins; D007202:Indicators and Reagents; D012116:Resins, Plant; D013867:Thiohydantoins