cCD79a expression in a case of plasma cell leukemia.
In the present report we analyzed the immunophenotype of the neoplastic cells in a case of primary plasma cell leukemia (PCL). We performed simultaneous analysis of bone marrow and peripheral blood samples to investigate minor phenotypic variations that could explain the tendency of a population to leave medullary compartments. No major differences were observed between the two populations. The phenotype of the malignant clone was: CD38+, CD138+, CD19-, CD56+, CD117-, CD33+, CD44 , CD49e , cCD79a+ with positive cytoplasmic stain for kappa and IgG. Our findings expands the potential uses of cCD79a to cases of PCL with atypical morphology.
Alonso
M L
ML
Department of Hematology, Hospital de la Santa Creu i Sant Pau, Secció de Marcadors, Barcelona, Spain.
Rubiol
E
E
Mateu
R
R
Estivill
C
C
Bellido
M
M
Balmaña
J
J
Nomdedéu
J F
JF
D000368:Aged; D015703:Antigens, CD / Q000032:analysis / Q000096:biosynthesis*; D051925:CD79 Antigens; D003593:Cytoplasm / Q000276:immunology; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D016130:Immunophenotyping; D007952:Leukemia, Plasma Cell / Q000276:immunology / Q000378:metabolism*; D010950:Plasma Cells / Q000276:immunology; D011947:Receptors, Antigen, B-Cell / Q000032:analysis / Q000096:biosynthesis*
D015703:Antigens, CD; D051925:CD79 Antigens; C497881:CD79A protein, human; D011947:Receptors, Antigen, B-Cell