Dopaminergic graft-induced long-term recovery of complex sensorimotor behaviors in a rat model of Parkinson's disease.
Transplantation of embryonic dopamine neurons has evolved as an alternative neurosurgical treatment strategy for patients with Parkinson's disease and it is therefore of great interest to further optimise this procedure in experimental studies. We have applied a modified microtransplantation approach in unilaterally 6-hydroxydopamine lesioned rats and observed a substantial and long-lasting functional recovery in complex spontaneous behaviors, such as skilled forelimb use and stepping behavior. The results demonstrate that the rat model of Parkinson's disease is a highly useful tool to study mechanisms of neural plasticity and regeneration. The ability of dopaminergic grafts to restore complex sensorimotor behaviors in animals also indicate their great potential for the development of a successful clinical application.
Nikkhah
G
G
Department of Neurosurgery, Nordstadt Hospital. GNikkhah@compuserve.com
Rosenthal
C
C
Falkenstein
G
G
Samii
M
M
D000818:Animals; D001931:Brain Mapping; D016380:Brain Tissue Transplantation / Q000473:pathology / Q000502:physiology*; D004298:Dopamine / Q000502:physiology*; D005260:Female; D016332:Fetal Tissue Transplantation / Q000473:pathology / Q000502:physiology*; D009048:Motor Skills / Q000187:drug effects / Q000502:physiology*; D009416:Nerve Regeneration / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology; D016627:Oxidopamine; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000473:pathology / Q000601:surgery*; D011597:Psychomotor Performance / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013378:Substantia Nigra / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D017557:Ventral Tegmental Area / Q000473:pathology / Q000503:physiopathology / Q000637:transplantation*
D016627:Oxidopamine; D004298:Dopamine