Thymocytes and cultured thymic epithelial cells express transcripts encoding alpha-3, alpha-5, and beta-4 subunits of neuronal nicotinic acetylcholine receptors. Preferential transcription of the alpha-3 and beta-4 genes by immature CD4+8+ thymocytes and evidence for response to nicotine in thymocytes.
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.
M
M
Mihovilovic
S
S
Denning
Y
Y
Mai
C M
CM
Fisher
L P
LP
Whichard
D D
DD
Patel
A D
AD
Roses
D015704:CD4 Antigens / Q000032:analysis; D016827:CD8 Antigens / Q000032:analysis; D002478:Cells, Cultured; D004847:Epithelial Cells / Q000502:physiology*; D006801:Humans; D046911:Macromolecular Substances; D009474:Neurons / Q000502:physiology; D009538:Nicotine / Q000494:pharmacology*; D011978:Receptors, Nicotinic / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics; D016176:T-Lymphocyte Subsets / Q000502:physiology; D013601:T-Lymphocytes / Q000187:drug effects / Q000502:physiology*; D013950:Thymus Gland / Q000166:cytology / Q000502:physiology*; D014158:Transcription, Genetic
D015704:CD4 Antigens; D016827:CD8 Antigens; D046911:Macromolecular Substances; D011978:Receptors, Nicotinic; D009538:Nicotine