Suppression by water extracts of Sophora plants of sucrose-induced hyperglycemia in rats and inhibition of intestinal disaccharidases in vitro.
Partially purified hot-water extracts of the roots of plants of the Sophora family suppressed the increase in blood glucose concentration of rats in the oral sugar tolerance test. The extracts also inhibited rat intestinal sucrase and maltase. The most potent sample was about 15 times more active than catechin, a positive control, in these experiments.
Department of Applied Biological Chemistry, Osaka Prefecture University, Japan.
H C
HC
Shi
Q Y
QY
Huang
R
R
Yamaji
H
H
Inui
T
T
Fujita
K
K
Miyatake
Y
Y
Nakano
T
T
Tada
K
K
Nishimura
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002392:Catechin / Q000494:pharmacology; D019422:Dietary Sucrose / Q000009:adverse effects*; D004186:Disaccharidases / Q000037:antagonists & inhibitors*; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors; D006943:Hyperglycemia / Q000139:chemically induced / Q000188:drug therapy*; D007421:Intestine, Small / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013393:Sucrase / Q000037:antagonists & inhibitors; D014867:Water / Q000737:chemistry
D001786:Blood Glucose; D019422:Dietary Sucrose; D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D010936:Plant Extracts; D014867:Water; D002392:Catechin; D004186:Disaccharidases; D013393:Sucrase