Zollinger-Ellison syndrome. Improved treatment options for this complex disorder.
Zollinger-Ellison syndrome is a rare disorder characterized by severe peptic ulcer disease, gastric acid hypersecretion, and non-beta islet cell tumors of the pancreas. Most gastrinomas are found within an anatomic area known as the gastrinoma triangle. However, they commonly occur in extrapancreatic sites in multiple endocrine neoplasia type 1 syndrome. In patients in whom Zollinger-Ellison syndrome is suspected, laboratory evidence of hypergastrinemia and hyperacidity establishes the diagnosis. Until the advent of proton pump inhibitors, total gastrectomy was the treatment of choice. Therapy with these agents (eg, omeprazole, lansoprazole) can prevent ulcer disease. However, surgical removal of gastrinomas offers a chance for cure and can improve longevity by preventing the malignant spread of the tumors.
Baylor College of Medicine, USA. wqureshi@bcm.tmc.edu
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Qureshi
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Rashid
D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D005743:Gastrectomy; D006801:Humans; D009853:Omeprazole / Q000627:therapeutic use; D011379:Prognosis; D015043:Zollinger-Ellison Syndrome / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*
D000897:Anti-Ulcer Agents; D004791:Enzyme Inhibitors; D009853:Omeprazole