Use of an oral antiseptic bioadhesive tablet in dogs.
V3703 (Stomadhex) is a tablet with bioadhesive properties enabling it to remain in place for several hours after it has been placed on the oral mucosa. It continuously releases chlorhexidine and niacinamide. In a study conducted in 15 dogs, the tablets were well tolerated by the animals. The product significantly reduced (p < 0.05): dental plaque; quantitative periodontopathogen and total anaerobic bacterial counts; spirochetes; and halitosis when used daily over a 14 day period. Gingivitis was also reduced, though not significantly (p = 0.07). Stomadhex treatment can provide a carry-over effect following dental scaling by reducing oral microflora and retarding the reappearance of dental plaque.
VETOQUINOL Research Centre, Lure, France.
P
P
Gruet
C
C
Gaillard
B
B
Boisramé
D
D
Duffaut
A M
AM
Grimoud
G
G
Camy
D000287:Administration, Topical; D000704:Analysis of Variance; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D001421:Bacteria, Anaerobic / Q000187:drug effects; D002710:Chlorhexidine / Q000008:administration & dosage*; D015169:Colony Count, Microbial; D003773:Dental Plaque / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy* / Q000382:microbiology; D004285:Dogs; D004338:Drug Combinations; D005891:Gingivitis / Q000188:drug therapy / Q000662:veterinary; D006209:Halitosis / Q000188:drug therapy / Q000662:veterinary*; D016014:Linear Models; D009061:Mouth Mucosa; D009536:Niacinamide / Q000008:administration & dosage*; D013144:Spirochaetales / Q000187:drug effects; D013607:Tablets
D000891:Anti-Infective Agents, Local; D004338:Drug Combinations; D013607:Tablets; D009536:Niacinamide; D002710:Chlorhexidine