[Mechanical physiopathology of remodeling peri-implant bone. The role of cytokine].
For a number of years titanium osteointegrated implants have represented a major step forward in dentistry, plastic and maxillofacial surgery, providing a lively stimulus to research both in their application and in the experimental field. The study of osteointegration has led to a more detailed knowledge of bone remodelling regulation mechanisms and the biological mediators involved. In this review the authors examine the role played by cytokines in the homeostasis of bone tissue, paying special reference to the phase of osteoclast activation and its possible effects on peri-implant bone resorption. The authors focus in particular on the effects of interleukin-6 (IL-6) as an important osteotropic factor and a hypothetical target on which to act in order to modulate its effects for therapeutical purposes.
Guidiceandrea
F
F
Clinica Chirurgica, Università degli Studi Tor Vergata Roma.
Cervelli
G
G
Grimaldi
M
M
Cervelli
V
V
D001861:Bone Regeneration; D016723:Bone Remodeling / Q000502:physiology; D016207:Cytokines / Q000378:metabolism; D003757:Dental Implantation; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism; D010010:Osteoclasts / Q000378:metabolism; D014025:Titanium
D016207:Cytokines; D015850:Interleukin-6; D014025:Titanium