Hypoxia upregulates inducible (Type II) nitric oxide synthase in an HIF-1 dependent manner in rat pulmonary microvascular but not aortic smooth muscle cells.
Palmer
L A
LA
Department of Anesthesiology, University of Virginia, Charlottesville 22906-0010, USA.
Johns
R A
RA
D000818:Animals; D001011:Aorta / Q000201:enzymology / Q000473:pathology; D004268:DNA-Binding Proteins / Q000378:metabolism; D000860:Hypoxia / Q000378:metabolism* / Q000473:pathology; D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000201:enzymology*; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D052247:Nitric Oxide Synthase Type II; D009687:Nuclear Proteins / Q000378:metabolism; D011651:Pulmonary Artery / Q000201:enzymology / Q000473:pathology; D051381:Rats; D014157:Transcription Factors / Q000378:metabolism; D014162:Transfection; D015854:Up-Regulation
D004268:DNA-Binding Proteins; C497444:Hif1a protein, rat; D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D009687:Nuclear Proteins; D014157:Transcription Factors; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; C496318:Nos2 protein, rat