Outcome and early childhood follow-up of chromosomally normal fetuses with increased nuchal translucency at 10-14 weeks' gestation.
The aim of this study was to evaluate pregnancy outcome and early childhood of chromosomally normal fetuses with increased nuchal translucency at 10-14 weeks' gestation. A total of 63 chromosomally normal fetuses with a first-trimester nuchal translucency thickness of 3 mm or more were evaluated. In ongoing pregnancies, follow-up scans were performed to detect or exclude additional structural anomalies in the fetus. Follow-up of the live-born children was by questionnaires sent to parents or reviews of medical records. In 11 fetuses, additional structural anomalies were diagnosed at follow-up scans; in this group there were five terminations of pregnancy, two intrauterine deaths, two neonatal deaths and two survivors. In addition, there were two unexplained intrauterine deaths. The remaining 50 pregnancies resulted in live births and the parents were sent questionnaires on the follow-up of their children. Responses were received on 34 children at 7-75 months of age. Twenty-nine children are healthy and five showed various minor health problems not related to the presence of increased nuchal translucency. These findings suggest that chromosomally normal fetuses with first-trimester increased nuchal translucency and normal follow-up scans have a good prognosis for a normal early childhood.
Department of Obstetrics and Gynecology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands.
J M
JM
Van Vugt
B W
BW
Tinnemans
R M
RM
Van Zalen-Sprock
D002657:Child Development / Q000502:physiology*; D002675:Child, Preschool; D002875:Chromosomes / Q000502:physiology*; D005069:Evaluation Studies as Topic; D005260:Female; D005313:Fetal Death; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008423:Maternal Age; D009333:Neck / Q000002:abnormalities / Q000000981:diagnostic imaging* / Q000196:embryology; D011247:Pregnancy; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First; D011379:Prognosis; D012307:Risk Factors; D011795:Surveys and Questionnaires; D016216:Ultrasonography, Prenatal