Tumor suppressor mutations in mice: the next generation.
Mouse strains carrying tumor suppressor mutations genetically mimic familial forms of human cancer. New tumor suppressors have and will be identified and mutated in the mouse; however, it is clear that future investigation will focus on a new generation of experiments aimed at improving existing models, and using them to delineate the molecular pathways to tumorigenesis and to test the value of rationally designed drug therapies.
McClatchey
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AI
Massachusetts General Hospital Cancer Center, Charlestown 02129, USA. mcclatch@helix.mgh.harvard.edu
Jacks
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D000818:Animals; D004195:Disease Models, Animal; D005544:Forecasting; D016147:Genes, Tumor Suppressor / Q000235:genetics*; D006801:Humans; D051379:Mice; D009154:Mutation; D009374:Neoplasms, Experimental / Q000235:genetics; D012106:Research / Q000639:trends