Aberrant DNA methylation of genomic regions translocated in myeloid malignancies.
The mechanism of aberrant genetic recombinatorial events in neoplasia is vaguely understood. One hypothesis is that aberrant DNA methylation may in some way predispose genomic regions to recombination. Using the t(9;22) of chronic myeloid leukemia (CML) and the t(15;17) of acute promyelocytic leukemia (APL) as models, our laboratory and others have gathered data supporting this hypothesis. These data are reviewed.
University of Minnesota Medical School, Minneapolis, USA.
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Litz
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Etzell
D019175:DNA Methylation; D015894:Genome, Human; D005854:Germ Cells / Q000502:physiology; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive; D007951:Leukemia, Myeloid / Q000235:genetics*; D015473:Leukemia, Promyelocytic, Acute / Q000235:genetics; D011995:Recombination, Genetic; D014178:Translocation, Genetic