Virulence of enterohemorrhagic Escherichia coli: role of molecular crosstalk.
Many bacterial exotoxins, originally defined by cytopathic effects, may also possess additional biological activities. The capacity of exotoxins to elicit the synthesis and secretion of pro- or anti-inflammatory cytokines may be as important as their direct toxic effects in pathogenesis. One example of such 'molecular crosstalk' occurs between Shiga toxins and the cytokines made in response to these toxins during the development of disease.
Dept of Medical Microbiology and Immunology, Texas A&M University Health Science Center, College Station 77843-1114, USA. tesh@medicine.tamu.edu
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D000818:Animals; D001427:Bacterial Toxins / Q000378:metabolism; D016207:Cytokines / Q000502:physiology*; D004760:Enterocolitis / Q000382:microbiology; D004768:Enterotoxins / Q000378:metabolism; D004926:Escherichia coli / Q000378:metabolism / Q000472:pathogenicity*; D019453:Escherichia coli O157 / Q000378:metabolism / Q000472:pathogenicity*; D006463:Hemolytic-Uremic Syndrome / Q000382:microbiology; D006801:Humans; D022603:Shiga Toxins; D015398:Signal Transduction; D014774:Virulence
D001427:Bacterial Toxins; D016207:Cytokines; D004768:Enterotoxins; D022603:Shiga Toxins