[Intravenous immunoglobulin (GB-0998) for prophylaxis of recurrent acute otitis media and lower respiratory tract infection in infancy with IgG 2 deficiency].
The prophylactic effect of intravenous immunoglobulin (GB-0998) on the recurrent acute otitis media, bronchitis and bronchopneumonia in IgG 2 deficient infants was investigated in a multicenter trial. GB-0998 was administered 6 times every 4 weeks. The doses were 300 mg/kg wt. during the first treatment, followed by 5 doses of 200 mg/kg wt. The results indicated that GB-0998 was effective in the prophylaxis of the recurrent infection of acute otitis media, bronchitis and bronchopneumonia in infancy with IgG 2 deficiency and/or IgG 2 antibody deficiency specific for Streptococcus pneumoniae.
Department of Pediatrics, School of Medicine, Hokkaido University.
Y
Y
Sakiyama
A
A
Komiyama
K
K
Shiraki
N
N
Taniguchi
S
S
Torii
S
S
Baba
J
J
Yata
S
S
Matsumoto
D000208:Acute Disease; D001991:Bronchitis / Q000517:prevention & control*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D017099:IgG Deficiency / Q000628:therapy*; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007223:Infant; D008297:Male; D010033:Otitis Media / Q000517:prevention & control*; D011014:Pneumonia / Q000517:prevention & control*; D012008:Recurrence
D016756:Immunoglobulins, Intravenous