Potential antiviral agents. Part II. Synthesis and antiviral evaluation of pyrazinones substituted with acyclic chains.
The synthesis of a series of 4'-substituted hydroxybutyl pyrazine analogues of the anti-herpes compound, acyclovir, is described. The compounds were characterized with 1H and 13C nmr, mass and IR spectroscopy. Antiviral (HSV-1, CMV, Cox B4, HIV-1) properties of these compounds were examined. None of these compounds were active against these viruses.
Davis
J
J
Laboratoire de Chimie des Substances Naturelles, Université de Limoges, France.
Benhaddou
R
R
Fedoryak
O
O
Granet
R
R
Krausz
P
P
Bliard
C
C
De Monte
M
M
Aubertin
A M
AM
D000212:Acyclovir / Q000031:analogs & derivatives* / Q000737:chemistry; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology*; D011719:Pyrazines / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology*
D000998:Antiviral Agents; D011719:Pyrazines; D000212:Acyclovir