Long-term selective IgG immuno-adsorption improves Rasmussen's encephalitis.
We report that long-term selective immunoglobulin G immunoadsorption by protein A (PAI) improved seizure frequency and neuropsychological deficits in a 16-year-old patient with severe treatment-resistant Rasmussen's encephalitis (RE). Clinical improvement correlated with reduction of antiglutamate receptor 3 antibodies. The efficacy of PAI in our patient supports the autoimmune hypothesis of RE and suggests its application to avoid, or at least delay, functional hemispherectomy in selected cases.
Antozzi
C
C
Neuromuscular Research Department, Istituto Nazionale Neurologico Carlo Besta, Milan, Italy.
Granata
T
T
Aurisano
N
N
Zardini
G
G
Confalonieri
P
P
Airaghi
G
G
Mantegazza
R
R
Spreafico
R
R
D000293:Adolescent; D001323:Autoantibodies / Q000302:isolation & purification*; D004660:Encephalitis / Q000276:immunology / Q000628:therapy*; D017036:Epilepsia Partialis Continua / Q000276:immunology / Q000628:therapy*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000302:isolation & purification*; D007164:Immunosorbents; D007802:Language; D009483:Neuropsychological Tests; D018094:Receptors, Metabotropic Glutamate / Q000276:immunology; D013205:Staphylococcal Protein A / Q000276:immunology
D001323:Autoantibodies; D007074:Immunoglobulin G; D007164:Immunosorbents; D018094:Receptors, Metabotropic Glutamate; D013205:Staphylococcal Protein A; C102718:metabotropic glutamate receptor 3