The thermosome: archetype of group II chaperonins.
The thermosome, the chaperonin of the archaea, and its homologue from the cytosol of eukaryotes, known as TRiC or CCT, form a distinct subfamily of the chaperonins that does not depend on a co-chaperonin for protein folding activity. Recent structural data obtained by cryo- electron microscopy and X-ray crystallography provide the first insights into a novel mechanism remarkably different from that of the bacterial GroEL-GroES system.
Max-Planck-Institut für Biochemie, Martinsried, Germany.
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Klumpp
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Baumeister
D000818:Animals; D019843:Archaeal Proteins / Q000737:chemistry* / Q000145:classification / Q000378:metabolism / Q000502:physiology; D001665:Binding Sites; D056404:Chaperonin Containing TCP-1; D018833:Chaperonins / Q000737:chemistry* / Q000145:classification / Q000378:metabolism / Q000502:physiology; D003600:Cytosol / Q000378:metabolism; D005057:Eukaryotic Cells / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins; D008869:Microtubule-Associated Proteins; D009687:Nuclear Proteins / Q000145:classification; D011487:Protein Conformation; D056405:Thermosomes; D044767:Ubiquitin-Protein Ligases; D056427:t-Complex Genome Region
D019843:Archaeal Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008869:Microtubule-Associated Proteins; D009687:Nuclear Proteins; C116196:PPP1R11 protein, human; D044767:Ubiquitin-Protein Ligases; D056404:Chaperonin Containing TCP-1; D018833:Chaperonins; D056405:Thermosomes