Severe vincristine toxicity in combination with itraconazole.
We report two patients with acute lymphoblastic leukaemia (ALL) who were entered into the current MRC adult ALL trial (UKALL XII) in whom unusually severe vincristine induced neurotoxicity developed. This appeared to be the result of an interaction with itraconazole suspension.
Gillies
J
J
Department of Haematology, Monklands District General Hospital, Airdrie, UK.
Hung
K A
KA
Fitzsimons
E
E
Soutar
R
R
D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001215:Asparaginase / Q000008:administration & dosage; D001228:Aspergillosis / Q000517:prevention & control; D000075202:Contraindications; D004317:Doxorubicin / Q000008:administration & dosage; D004347:Drug Interactions; D017615:Enteric Nervous System / Q000187:drug effects*; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced; D008658:Inactivation, Metabolic; D007177:Inappropriate ADH Syndrome / Q000139:chemically induced*; D007418:Intestinal Pseudo-Obstruction / Q000139:chemically induced*; D017964:Itraconazole / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D008099:Liver / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D011239:Prednisolone / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology
D000935:Antifungal Agents; D017964:Itraconazole; D014750:Vincristine; D004317:Doxorubicin; D011239:Prednisolone; D001215:Asparaginase