Synthesis and antiviral evaluation of analogs of adenosine-N1-oxide and 1-(Benzyloxy)adenosine.
The activity of a series of compounds related to adenosine-N1-oxide (1) and 1-(benzyloxy)adenosine (42) against vaccinia virus has been determined both in vitro and in a vaccinia mouse tailpox model. Significant activities have been found both in vitro and in vivo for a number of the synthetic compounds.
Kwong
C D
CD
Southern Research Institute, Birmingham, Alabama 35255-5305, USA.
Krauth
C A
CA
Shortnacy-Fowler
A T
AT
Arnett
G
G
Hollingshead
M G
MG
Shannon
W M
WM
Montgomery
J A
JA
Secrist
J A
JA
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D003497:Cyclic N-Oxides / Q000737:chemistry* / Q000494:pharmacology; D051379:Mice; D014615:Vaccinia / Q000188:drug therapy*; D014616:Vaccinia virus / Q000187:drug effects*
D000998:Antiviral Agents; D003497:Cyclic N-Oxides; C095544:adenosine N(1)-oxide; D000241:Adenosine