A new furanosesterterpene from the South African nudibranch Hypselodoris capensis and a dictyoceratida sponge.
The known cytotoxic, linear beta-substituted sesterterpenes (18R)-variabilin (1) and 22-deoxyvariabilin (4) and a new variant, 22-deoxy-23-hydroxymethylvariabilin (5), were isolated from the endemic South African nudibranch Hypselodoris capensis together with the known ichthyotoxic sesquiterpenes nakafuran-8 (2) and -9 (3). One of H. capensis' dietary sponges, a Fasciospongia sp. collected simultaneously with the nudibranchs, yielded sesterterpenes 1, 4, and 5 and the ubiquitous prenylated furan derivative, furospinosulin-1 (7).
Department of Chemistry, Rhodes University, Grahamstown, 6140, South Africa, and Zoology Department, University of Port Elizabeth, Port Elizabeth, South Africa.
K
K
McPhail
M T
MT
Davies-Coleman
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P
Coetzee
D000818:Animals; D002240:Carbohydrate Sequence; D005663:Furans / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008969:Molecular Sequence Data; D008974:Mollusca / Q000737:chemistry*; D011161:Porifera / Q000737:chemistry*; D013019:South Africa; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013729:Terpenes / Q000302:isolation & purification*
C113747:22-deoxy-23-hydroxymethylvariabilin; D005663:Furans; D013729:Terpenes