Endocytosis and intracellular sorting of receptor tyrosine kinases.
Binding of the peptide growth factors (GF) on their surface receptors triggers rapid endocytosis of ligand-receptor complexes via clathrin-coated pits. Internalized receptors pass through the endosomal compartment where they are efficiently sorted to the lysosomal degradation pathway. Accelerated internalization and degradation of GF receptors leads to dramatic down-regulation of the receptors. Hence, we discuss the pathways, molecular mechanisms and the biological role of the GF-induced receptor endocytosis and lysosomal targeting. The endocytosis of epidermal growth factor (EGF) receptor is employed as a model system to describe the role of clathrin, clathrin adaptors and other proteins in the recruitment of receptors into coated pits and in the endosomal sorting process.
Department of Pharmacology, University of Colorado Health Sciences Center, Denver, CO 80262, USA. alexander.sorkin@uchsc.edu
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Alexander
D004705:Endocytosis / Q000502:physiology*; D042541:Intracellular Space / Q000378:metabolism*; D021381:Protein Transport / Q000502:physiology; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*
D020794:Receptor Protein-Tyrosine Kinases