Immobilization strategies for biological scanning probe microscopy.
Biological atomic force microscopy (AFM) is now established as a method for studying the structure and function of biomolecular objects at the solid-liquid interface. Major progress in this field is linked to new developments in instrumentation, a better understanding of tip-sample interactions, and improved sample preparation techniques. In this review, the most common strategies for biomolecular immobilization with respect to biological AFM applications are summarized.
Department of Biochemistry, Stanford University Medical Center, CA 94305-5307, USA. pwagner@stanford.edu
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D018625:Microscopy, Atomic Force / Q000379:methods*