Gas-chromatographic study on the stereoselectivity of deprenyl metabolism.
The metabolism and urinary elimination of both (-)-deprenyl and (+)-deprenyl have been studied. Gas-chromatographic analysis with mass specific detection indicated that the metabolism of (-)-deprenyl results in a large excess of methamphetamine compared to amphetamine, while the metabolism of (+)-deprenyl gave nearly equal amounts of amphetamine and methamphetamine. A novel deprenyl metabolite, phenylacetone, was also identified in our studies.
Tarjányi
Z
Z
Department of Pharmacology, Semmelweis University of Medicine, Budapest, Hungary.
Kalász
H
H
Szebeni
G
G
Hollósi
I
I
Báthori
M
M
Fürst
S
S
D000661:Amphetamine / Q000652:urine; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000652:urine; D008996:Monoamine Oxidase Inhibitors / Q000737:chemistry / Q000493:pharmacokinetics* / Q000652:urine; D018696:Neuroprotective Agents / Q000737:chemistry / Q000493:pharmacokinetics* / Q000652:urine; D012642:Selegiline / Q000737:chemistry / Q000493:pharmacokinetics* / Q000652:urine; D013237:Stereoisomerism
D008996:Monoamine Oxidase Inhibitors; D018696:Neuroprotective Agents; D012642:Selegiline; D008694:Methamphetamine; D000661:Amphetamine