Genome scan of European-American schizophrenia pedigrees: results of the NIMH Genetics Initiative and Millennium Consortium.
The Genetics Initiative of the National Institute of Mental Health (NIMH) was a multisite study that created a national repository of DNA from families informative for genetic linkage studies of schizophrenia, bipolar disorder, and Alzheimer's disease. The schizophrenia families were collected by three sites: Washington University, Harvard University, and Columbia University. This article, one in a series that describes the data collected for linkage analysis by the schizophrenia consortium, presents the results for the European-American sample. The European-American sample comprised 43 nuclear families and 146 subjects. Ninety-six of the family members were considered affected by virtue of having received a DSM-III-R diagnosis of schizophrenia (N = 82) or schizoaffective disorder, depressed (N = 14). The families contained a total of 50 independent sib-pairs. Using the significance threshold criteria suggested by Lander and Kruglyak [(1995): Nat Genet 241-247], no region showed statistically significant evidence for linkage; two markers on chromosome 10p showed statistical evidence suggestive of linkage using the criteria of Lander and Kruglyak [(1995): Nat Genet 241-247]: D10S1423 (nonparametric linkage (NPL) Z = 3.4, P = .0004) and its neighbor, D10S582 (NPL Z = 3.2, P = .0006).
Faraone
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Department of Psychiatry, Harvard Medical School at Massachusetts Mental Health Center, Boston, USA.
Matise
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Svrakic
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Pepple
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Malaspina
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Suarez
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Hampe
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Zambuto
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Schmitt
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Meyer
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Markel
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Lee
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Harkavy Friedman
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Kaufmann
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Cloninger
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Tsuang
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D000293:Adolescent; D000328:Adult; D000368:Aged; D002874:Chromosome Mapping; D005060:Europe; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D015894:Genome, Human; D006801:Humans; D008297:Male; D008875:Middle Aged; D009316:National Institutes of Health (U.S.); D010375:Pedigree; D012559:Schizophrenia / Q000235:genetics*; D014481:United States; D044465:White People / Q000235:genetics*
D005819:Genetic Markers