Identification of the sensory/motor area and pathologic regions using ECoG coherence.
An electrophysiologic mapping technique which enables identification of the central sulcus and pathologic cortical regions is described. Electrocorticographic recordings of 1 min duration were recorded from 25 patients who were undergoing resection of tumors in the sensory-motor region or being evaluated for temporal lobectomy for epilepsy. Analysis of the patterns of subdural inter-electrode coherence revealed low coherence across the central sulcus for 11/12 cases where its location could be verified with direct cortical stimulation and/or somatosensory evoked potential mapping. Regions of high coherence identified the location of tumors in the sensory-motor region for 10/10 cases. Over the temporal lobe, localized areas of high coherence were evident in 8/9 epilepsy patients, but were not indicative of the location of mesial temporal lobe tumors or inter-ictal spiking, when present. We conclude that analysis of cortical coherence patterns may be helpful for revealing the location of pathologic processes relative to critical cortical areas.
Department of Neurology, The University of Chicago, Illinois 60637, USA. v-towle@uchicago.edu
V L
VL
Towle
I
I
Syed
C
C
Berger
R
R
Grzesczcuk
J
J
Milton
R K
RK
Erickson
P
P
Cogen
E
E
Berkson
J P
JP
Spire
D000293:Adolescent; D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D001927:Brain Diseases / Q000175:diagnosis* / Q000503:physiopathology; D001931:Brain Mapping; D001932:Brain Neoplasms / Q000175:diagnosis / Q000503:physiopathology; D002540:Cerebral Cortex / Q000503:physiopathology*; D002648:Child; D004569:Electroencephalography; D004827:Epilepsy / Q000175:diagnosis / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology*; D012677:Sensation / Q000502:physiology*