[Direct cytotoxic and cytoprotective effects of some drugs on isolated cells of gastric mucosa from rats].
Toxic effect of ethanol and indomethacin, and the cytoprotective effect of prostacyclin were studied. In absence of other aggressive factors, the indomethacin was found to be non-toxic, but it could enhance the necrotizing effect of ethanol, this effect could be counteracted by prostacyclin preincubation. These observations suggest that there is an endogenous prostaglandin system in rat gastric mucosal cells that may protect against the toxic effect of indomethacin; administered prostacyclin may have a cytoprotective effect when this endogenous prostaglandin system's protective function does not more function. Gastric mucosal cytoprotection may include cellular level processes, which are able to operate without the existence of tissue integrity.
Pécsi Orvostudományi Egyetem, I. Belklinika.
I
I
Szabó
B
B
Bódis
L
L
Nagy
G
G
Mózsik
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D019610:Cytoprotection; D003601:Cytotoxicity Tests, Immunologic; D011464:Epoprostenol / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000166:cytology* / Q000187:drug effects; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000891:Anti-Infective Agents, Local; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000431:Ethanol; D011464:Epoprostenol; D007213:Indomethacin