Electroretinograms of albino and pigmented guinea-pigs (Cavia porcellus).
OBJECTIVE
The present study compares the electroretinogram responses of albino and pigmented guinea-pigs (Cavia porcellus) with data published for the rat and mouse.


RESULTS
We found that albino guinea-pigs gave significantly larger amplitudes and faster implicit times for a-wave and peak-to-peak responses than did pigmented animals. In contrast, pigmented and albino rats and mice do not show such differences between strains.


CONCLUSIONS
We suggest that the guinea-pig may be a better model of the retinal response in human albinism as their response characteristics are consistent with those published for humans.
Bui
B V
BV
Department of Optometry and Vision Sciences, University of Melbourne, Parkville, Victoria, Australia.
Sinclair
A J
AJ
Vingrys
A J
AJ
D000417:Albinism / Q000503:physiopathology*; D000818:Animals; D003623:Dark Adaptation; D004596:Electroretinography; D006168:Guinea Pigs; D051379:Mice; D010858:Pigmentation; D051381:Rats; D012160:Retina / Q000502:physiology*; D012684:Sensory Thresholds; D013045:Species Specificity