[Chemokines and their receptors: 2 new actors in the physiopathology of HIV infection].
The discovery of two novel structures (CXCR4, CCR5) that act as HIV-1 coreceptors in target cells has allowed a better understanding of the virus-cell interaction. The recent discovery that chemokines interact with the same receptors as HIV-1 has shed light in the comprehension of the viral molecular biology and pathophysiology, setting the stage for new efforts aimed at blocking virus-cell interaction.
Memorial Health Care, Worcester, MA, USA.
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Davaro
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Bottaro
D015658:HIV Infections / Q000503:physiopathology*; D015497:HIV-1; D019713:Receptors, CCR5 / Q000502:physiology; D019718:Receptors, CXCR4 / Q000502:physiology; D019707:Receptors, Chemokine / Q000502:physiology*
D019713:Receptors, CCR5; D019718:Receptors, CXCR4; D019707:Receptors, Chemokine