Electrodeposition of radioactive rhenium onto stents to prevent restenosis.
Radioactive stents are currently being evaluated for preventing restenosis. A major difficulty to overcome is the need to load any pre-manufactured stents with defined amounts of radioactivity at the time of use. Using stents that are preloaded by the manufacturer is not ideal because the stent length usually differs from the length needed for a specific lesion and the amounts of radioactivity varies widely due to ongoing decay of the source. Thus, we have developed a novel method that allows any currently used stainless steel or tantalum stent to be coated with radioactive rhenium. The method involves placing the stent in a series of rinsing and electroplating solutions, one containing radioactive rhenium (186Re, 188Re, or both). The overall processing time is 15 min and the procedure may be conveniently applied just prior to the stent insertion. The plated stent contains radioactive rhenium in a 1.2 microm-thick cobalt layer, with an outer 2 microm layer of gold. The gold layer gives the radioactive stent excellent radiochemical stability, good bending and biocompatibility properties, and improves stent visibility during fluoroscopy.
Häfeli
U O
UO
Radiation Oncology Department, The Cleveland Clinic Foundation, OH 44195, USA. hafeliu@cesmtp.ccf.org
Warburton
M C
MC
Landau
U
U
D015906:Angioplasty, Balloon, Coronary; D001672:Biocompatible Materials; D003035:Cobalt; D003327:Coronary Disease / Q000517:prevention & control; D004577:Electron Probe Microanalysis; D004595:Electroplating / Q000379:methods*; D006046:Gold; D006801:Humans; D008855:Microscopy, Electron, Scanning; D011183:Postoperative Complications / Q000517:prevention & control; D011786:Quality Control; D011868:Radioisotopes / Q000627:therapeutic use; D012211:Rhenium / Q000627:therapeutic use; D013193:Stainless Steel; D015607:Stents; D013499:Surface Properties
D001672:Biocompatible Materials; D011868:Radioisotopes; D013193:Stainless Steel; D003035:Cobalt; D012211:Rhenium; D006046:Gold