Neuropsychological consequences of epilepsy surgery in frontal lobe epilepsy.
The present study investigated the effect of frontal lobe surgery on "cognitive functions", which have previously been shown to be discriminative in the evaluation of non-resected patients with frontal lobe epilepsy (FLE). The cognitive outcome was evaluated with particular consideration of the side (left/right), the site (lateral, orbital, mesial, premotor/SMA), the type of surgery (resections vs. resections plus multiple subpial transections; MST), and seizure outcome. The evaluation is based on 33 patients with left (n = 17) or right (n = 16) frontal surgery. Forty-five patients who underwent successful left (n = 21) or right (n = 24) temporal lobectomy served as controls. The neuropsychological examination covered speed/attention, motor sequencing/coordination, response maintenance/inhibition, short-term memory, and language. With the exception of short-term memory, the chosen tests were discriminative in determining preoperative frontal lobe dysfunctions but they did not differentiate patients with a different lateralization or localization of the frontal focus. At the 3 month follow-up examination, patients with temporal lobectomy had improved frontal functions, whereas patients with frontal lobe surgery showed a mild deterioration. Within the frontally resected group, completely seizure-free patients had significantly improved short-term memory. Further consideration of the side, site and the type of the frontal resection indicated that patients with premotor/SMA surgery and patients with precentral/central MST had additional impairment after surgery. Premotor/SMA resections led to a deterioration in response maintenance/inhibition and if performed left sided also to deteriorated language functions. The latter impairment could be clearly related to transient aphasia directly after surgery. Irrespective of pareses observed immediately after surgery, patients with MSTs of the precentral/central areas displayed additional problems in motor coordination at the follow-up examination. In this group the seizure outcome was also less favourable. In summing up, frontal lobe surgery does not cause any considerable additional impairment in the short-term follow-up. However, caution is recommended when surgery or MST affect functional relevant cortex (here the prefrontal/SMA and precentral/central area). Finally, a release of functions associated with frontal areas not affected by surgery is suggested, when seizures are successfully controlled by surgery.
Helmstaedter
C
C
University Hospital of Epileptology, Bonn, Germany. psych@mailer.meb.uni-bonn.de
Gleibner
U
U
Zentner
J
J
Elger
C E
CE
D000328:Adult; D000704:Analysis of Variance; D001288:Attention / Q000502:physiology; D016022:Case-Control Studies; D002541:Cerebral Decortication / Q000009:adverse effects*; D003072:Cognition Disorders / Q000209:etiology / Q000503:physiopathology; D017034:Epilepsy, Frontal Lobe / Q000503:physiopathology / Q000601:surgery; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology / Q000601:surgery; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D007266:Inhibition, Psychological; D007806:Language Disorders / Q000209:etiology / Q000503:physiopathology; D008137:Longitudinal Studies; D008297:Male; D008569:Memory Disorders / Q000209:etiology / Q000503:physiopathology; D008570:Memory, Short-Term / Q000502:physiology; D009044:Motor Cortex / Q000503:physiopathology / Q000601:surgery; D009048:Motor Skills / Q000502:physiology; D009483:Neuropsychological Tests / Q000592:standards; D011930:Reaction Time / Q000502:physiology; D012016:Reference Values; D015203:Reproducibility of Results; D012640:Seizures / Q000150:complications; D013702:Temporal Lobe / Q000503:physiopathology / Q000601:surgery; D016896:Treatment Outcome