A model of hippocampal memory encoding and retrieval: GABAergic control of synaptic plasticity.
The current view of the role of GABAergic interneurones in cortical-network function has shifted from one of merely dampening neuronal activity to that of an active role in information processing. In this review, we explore a potential role of hippocampal GABAergic interneurones in providing spatial and temporal conditions for modifications of synaptic weights during hippocampus-dependent memory processes. We argue that knowledge of spatiotemporal activity patterns in distinct classes of interneurone is essential to understanding the cellular mechanisms underlying learning and memory.
MRC Anatomical Neuropharmacology Unit, University Dept of Pharmacology, Oxford, UK.
O
O
Paulsen
E I
EI
Moser
D004569:Electroencephalography; D006624:Hippocampus / Q000502:physiology* / Q000648:ultrastructure; D006801:Humans; D008568:Memory / Q000502:physiology*; D008606:Mental Processes / Q000145:classification / Q000502:physiology; D008959:Models, Neurological; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000145:classification / Q000648:ultrastructure; D018079:Receptors, GABA / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000096:biosynthesis*
D018079:Receptors, GABA; D005680:gamma-Aminobutyric Acid