Disappearance of diurnal rhythm of energy expenditure in genetically diabetic obese rats.
The daily profile of energy expenditures was examined in the new animal model of genetically diabetic obese rats. The diurnal rhythm was observed at 8 weeks of age, with highest and lowest values for energy consumption per hour observed in the dark and light periods, respectively. However, at 24 weeks of age after the manifestation of noninsulin-dependent diabetes mellitus, the rhythm completely disappeared, but it did not in the control rats.
Department of Nutrition, Tokyo Metropolitan Institute of Gerontology, Tokyo, 173-0015, Japan.
M
M
Ichikawa
K
K
Miyasaka
Y
Y
Fujita
T
T
Shimazoe
A
A
Funakoshi
D000818:Animals; D002940:Circadian Rhythm / Q000235:genetics*; D003624:Darkness; D003920:Diabetes Mellitus / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D004734:Energy Metabolism / Q000235:genetics*; D008027:Light; D008297:Male; D009765:Obesity; D051381:Rats