CD4+ and CD8+ T-lymphocytopenia in a filly with Pneumocystis carinii pneumonia.
Decreased proportion of CD4+ and CD8+ T lymphocytes in peripheral blood likely contributed to susceptibility to Pneumocystis carinii in a foal. Cytological evaluation of bronchoalveolar lavage was required for identification of the pathogen and serial flow-cytometric analysis of peripheral blood lymphocytes documented transient low expression of CD4+ and CD8+ T lymphocytes. Although immunodeficiency is uncommon, it must be included in the differential diagnosis for patients suffering from chronic or opportunistic infections and may provide an indication for immunostimulant therapy.
Flaminio
M J
MJ
Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan 66506-5606, USA.
Rush
B R
BR
Cox
J H
JH
Moore
W E
WE
D000818:Animals; D015496:CD4-Positive T-Lymphocytes; D018414:CD8-Positive T-Lymphocytes; D003937:Diagnosis, Differential; D005260:Female; D006734:Horse Diseases / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D006736:Horses; D008231:Lymphopenia / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D011020:Pneumonia, Pneumocystis / Q000175:diagnosis / Q000276:immunology / Q000662:veterinary*