Beta-thromboglobulin in urine and plasma: influence of coronary risk factors.
Blood platelet activation in vivo was evaluated by measuring beta-thromboglobulin in plasma and high molecular weight beta-thromboglobulin in urine in hypertensive smoking and nonsmoking middle-aged men (n=36) and in normotensive age-matched controls (n=40). We found no significant linear relationships between nocturnal or resting urinary high molecular weight beta-thromboglobulin and plasma beta-thromboglobulin in the combined hypertensive and normotensive groups. The excretion of high molecular weight beta-thromboglobulin correlated significantly with diastolic blood pressure when all subjects were pooled. After 60 minutes supine rest, nonsmokers had higher excretion of high molecular weight beta-thromboglobulin than smokers. Plasma beta-thromboglobulin levels tended to be higher in hypertensives. In multivariate analyses, resting high molecular weight beta-thromboglobulin excretion was positively related to diastolic blood pressure and negatively related to smoking, whereas plasma beta-thromboglobulin was positively related to diastolic blood pressure and inversely related to apolipoprotein A1 and B. We conclude that urinary high molecular weight beta-thromboglobulin and plasma beta-thromboglobulin are not closely related, but are complementary analyses, as there are methodological confounders for both variables.
Department of Cardiology, Ullevål University Hospital, Oslo, Norway.
H H
HH
Mundal
P
P
Hjemdahl
P
P
Urdal
P
P
Kierulf
C
C
Perneby
K
K
Berg
K
K
Gjesdal
D000328:Adult; D001794:Blood Pressure; D003327:Coronary Disease / Q000097:blood / Q000209:etiology* / Q000652:urine; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D015539:Platelet Activation; D012307:Risk Factors; D012907:Smoking; D001620:beta-Thromboglobulin / Q000378:metabolism*
D001620:beta-Thromboglobulin