[Molecular characteristics of RB1 tumor suppressor gene].
RB1 tumor suppressor gene is implicated in the development of some malignancies, among which retinoblastoma is the most common; in this tumor RB1 gene is generally deleted. This gene is closely associated to the cell cycle regulation and it constitutes a molecular binding target of viral oncoproteins, which inhibits its protein product, thus interrupting cell cycle progression. This paper describes its molecular features, in order to identify its mutations.
Hospital Municipal de Oncología María Curie, Buenos Aires, Argentina.
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Boquete
D016161:Genes, Retinoblastoma; D016147:Genes, Tumor Suppressor / Q000235:genetics*; D006801:Humans; D012175:Retinoblastoma / Q000235:genetics*