Bloodstream infections in HIV-positive patients: a review of sixty-eight episodes.
A retrospective review of all episodes of bloodstream infection (BSI) in HIV-positive patients admitted to the Infectious Diseases Unit at the Pisa General Hospital from 1991 to 1994 was performed. Sixty-eight episodes of BSI were recorded in 61 patients (5.8% of all patients admitted for HIV infection). BSI was community-acquired in 64.7% of cases. The patients were mainly male and i.v. drug abusers with a mean age of 33.8 yrs +/- 5.6 S.D. Sixty-four episodes occurred in AIDS patients (CDC criteria). CD4 count was less than 100 in 49 patients. The most frequent isolates were coagulase-negative staphylococci 33, S. aureus 7, Pseudomonas spp 7, fungi 1, non-typhoidal Salmonella 4. The most common sources of BSI were the skin or subcutaneous tissue infections and intravascular catheters. The overall mortality associated with BSI was 27.3%. Vancomycin and teicoplanin were active in vitro against all but one of the staphylococcal isolates.
Department of Medicine, University of Pisa, Hospital of Pisa, Italy.
M
M
Bonadio
C
C
Gigli
O
O
Maccanti
B
B
Longo
A
A
Smorfa
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000150:complications; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000097:blood* / Q000188:drug therapy / Q000382:microbiology; D018791:CD4 Lymphocyte Count; D005260:Female; D016469:Fungemia / Q000097:blood* / Q000188:drug therapy / Q000382:microbiology; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D015658:HIV Infections / Q000097:blood* / Q000150:complications; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D012189:Retrospective Studies
D000900:Anti-Bacterial Agents