Solitary enchondroma with clonal chromosomal abnormalities.
We report a case of a solitary enchondroma located in the head of the left fibula in a 50-year-old patient and present the findings of histopathologic investigation and cytogenetic analysis. The tumor revealed simple karyotypic abnormalities with t(8;17)(q23;p13) and loss of chromosomes 9, 19, and 22 as clonal chromosomal changes. Only a few enchondromas with chromosome aberrations have been published previously; nevertheless, it appears that benign and malignant cartilaginous tumors may have similar chromosomal abnormalities.
Institute of Pathology, Medical Faculty, Technical University of Aachen, Germany.
B
B
Gunawan
M
M
Weber
F
F
Bergmann
J
J
Wildberger
L
L
Füzesi
D001859:Bone Neoplasms / Q000235:genetics*; D002812:Chondroma / Q000235:genetics*; D002872:Chromosome Deletion; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic