'Ascospore O', Oxidant, host assistance: the pathway to carcinogenesis.
Sufficient evidence exists to conclude that a cycle of sequential physiological events is the pathway contributing to the transformation of the mammalian cell to its malignant phase. The cycle of events involves a reticulum or network of cells. These consist either of the reticuloendothelial cells, the squamous, or the epithelial group. A second factor requires the presence, intracellularly, of conidia derived from one of the various groups of the anaerobic micro-organisms known as Ascomycetes. These conidia as a separate entity, totally free of any part of their parental origin, constitute the invasive agent which, however, can or may lie quiescent at the onset. They retain genetically an electronegative viable chemical complex (Oxidant) and also an asexual procreative unit. This Oxidant can alternately accept the negative charged ions (anions) while releasing oxygen. The subsequent ensuing circulation and compatible flow of blood by the host provides the source for the electrolytes as well as the metabolites, enzymes, etc. It is this continued flow of blood that promotes the next stage of the conidia's lifecycle and reactivates their anaerobic respiration, metabolism, and reproduction of new asexual conidia. This is the cycle of physiological events that ultimately contributes to the transformation of an animal (human) cell to its malignant phase. It also accounts for the pathological consequences as clinically present in malignantly ill patients.
Greater Detroit Hospital and Medical Center, Inc., MI 48212, USA.
M W
MW
White
D000818:Animals; D002471:Cell Transformation, Neoplastic; D006801:Humans; D008954:Models, Biological; D016877:Oxidants / Q000502:physiology*; D013171:Spores, Bacterial; D013172:Spores, Fungal
D016877:Oxidants