Homology-based fold predictions for Mycoplasma genitalium proteins.
Homology search techniques based on the iterative PSI-BLAST method in combination with various filters for low sequence complexity are applied to assign folds to all Mycoplasma genitalium proteins. The resulting procedure (implemented as a web server) is able to predict at least one domain in 37% of these proteins automatically, with an estimated accuracy higher than 98%. Taking structural features such as coiled coil or transmembrane regions aside, folds can be assigned to more than half of the globular proteins in a bacterium just by iterative sequence comparison.
Huynen
M
M
EMBL, Max-Delbrück-Center for Molecular Medicine, Meyerhoftstr.1, Heidelberg, 69012, Germany.
Doerks
T
T
Eisenhaber
F
F
Orengo
C
C
Sunyaev
S
S
Yuan
Y
Y
Bork
P
P
D001426:Bacterial Proteins / Q000737:chemistry*; D009174:Mycoplasma / Q000737:chemistry*; D011487:Protein Conformation; D017510:Protein Folding; D017385:Sequence Homology
D001426:Bacterial Proteins