[Experimental echinococcosis and alveococcosis and a trial of the preparation SK-1].
In autobred albino mice, the maximum nonlethal dose of the agent CK-1 was established, which was 19.0 g/kg, the agent was nontoxic. Cotton rats aged 30-45 days were infected by alveococcosis from a donor rat. The methods and formulas developed by Mikhaĭlitsin et al. were used during experiments and investigations. At the beginning of treatment, 5 rats were found to have a great deal of parasitic larvocysts (PL) 10 days after infection. Eight rats formed a control group, 8 were treated with CK-1 in a constantly increasing doses of 0.1, 0.26, and 0.34 g/kg for 3 weeks. Following 40 days of infection, the animals were anesthesized and CK-1 was ascertained to have a high antialveococcal activity: the index of suppressed PL growth was 90.23 to 92.74%. In 14 piglets aged 1 month, infected by echinococcosis strains and treated CK-1 in high doses, was established to cause echinococcal death. In 14 puppies, the agent was highly effective in strobular echinococcosis.
Chebyshev
N V
NV
Streliaeva
A V
AV
Kovalenko
F P
FP
Sadykov
V M
VM
Samylina
I A
IA
Razakov
Sh A
ShA
Ganizoda
Kh G
KhG
Sabirov
B U
BU
D000818:Animals; D000923:Anticestodal Agents / Q000627:therapeutic use* / Q000633:toxicity; D004195:Disease Models, Animal; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004443:Echinococcosis / Q000188:drug therapy* / Q000469:parasitology; D005260:Female; D008297:Male; D051379:Mice; D016205:Sigmodontinae; D013552:Swine; D013997:Time Factors
D000923:Anticestodal Agents