Novel disulfide oxidoreductase in search of a function.
The high-resolution structure of an oxidoreductase from the archaeon Pyrococcus furiosus shows that it comprises two adjacent domains each with the thioredoxin (trx/grx) fold. Its functional properties are not yet fully defined but it may be related to the multi-domain eukaryotic protein disulfide-isomerases.
R B
RB
Freedman
D001665:Binding Sites; D009247:NADH, NADPH Oxidoreductases / Q000737:chemistry* / Q000502:physiology*; D011487:Protein Conformation; D017510:Protein Folding; D017433:Protein Structure, Secondary; D019711:Pyrococcus / Q000201:enzymology*
D009247:NADH, NADPH Oxidoreductases; C113416:protein disulfide oxidoreductase, P. furiosus