Effect of aminoguanidine on optic nerve involvement in experimental diabetic rats.
The effect of aminoguanidine (AG) on structural abnormalities in optic nerve fibers was evaluated in streptozotocin-induced diabetic rats. Morphometry of myelinated optic nerve fibers showed a partial amelioration on the reduction of the axon size but complete preservation of myelin size with low dose (25 mg kg-1 body weight) AG treatment. High dose (100 mg kg-1 body weight) AG completely prevented myelinated nerve fiber atrophy. These findings indicated that nonenzymatic glycation contributes to the development of optic nerve changes in diabetic rats.
Ino-ue
M
M
Department of Ophthalmology, School of Medicine, Kobe University 7-5-2, Kusunoki-Cho, Chuo-ku, Kobe 650-0017, Japan. mymam956@mailgate.kobe-u.ac.jp
Ohgiya
N
N
Yamamoto
M
M
D000818:Animals; D001835:Body Weight; D003921:Diabetes Mellitus, Experimental / Q000150:complications*; D003929:Diabetic Neuropathies / Q000188:drug therapy* / Q000201:enzymology; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors / Q000378:metabolism; D006146:Guanidines / Q000494:pharmacology*; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000187:drug effects / Q000378:metabolism; D009901:Optic Nerve Diseases / Q000188:drug therapy* / Q000201:enzymology; D051381:Rats; D017208:Rats, Wistar
D004791:Enzyme Inhibitors; D017127:Glycation End Products, Advanced; D006146:Guanidines; C004479:pimagedine