Percutaneous absorption of disopyramide, lidocaine and trimecaine.
Promoting effect of cyclic monoterpenes on percutaneous absorption of antiarrythmics drugs disopyramide, lidocaine and trimecaine was investigated in the rats. Laurocapram (Azone) was used as a standard comparator of penetration enhancement. The absorption of trimecaine was significantly enhanced by addition of limonene, trans-p-menthane and Azone in 1% concentration. Lidocaine and disopyramide penetrated across the skin only when 1% of limonene was used. Other cyclic monoterpenes showed no effect on percutaneous absorption of examined drugs.
Glaxo Wellcome s.r.o., Prague, Czech Republic.
J
J
Príborský
K
K
Kikuchi
K
K
Takayama
T
T
Nagai
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000493:pharmacokinetics*; D053138:Cyclohexenes; D004206:Disopyramide / Q000493:pharmacokinetics*; D008012:Lidocaine / Q000493:pharmacokinetics*; D000077222:Limonene; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012869:Skin Absorption; D012997:Solvents / Q000494:pharmacology; D013729:Terpenes / Q000494:pharmacology; D014288:Trimecaine / Q000493:pharmacokinetics*
D000889:Anti-Arrhythmia Agents; D053138:Cyclohexenes; D012997:Solvents; D013729:Terpenes; D008012:Lidocaine; D000077222:Limonene; D004206:Disopyramide; D014288:Trimecaine