Changes in Doppler ultrasonography in asphyxiated term infants with hypoxic-ischaemic encephalopathy.
Cerebral blood flow velocity was assessed by pulsed-Doppler ultrasonography in 39 asphyxiated and 35 healthy term newborn infants during the first days of life. Asphyxiated infants, investigated at the age of 12 +/- 2 h, with moderate stage hypoxic-ischaemic encephalopathy (HIE) (n = 7) had decreased (15.6 +/- 3.9 cm/s) and infants with severe stage of HIE (n = 8) increased (26.5 +/- 9.6 cm/s) mean cerebral blood flow velocity in medial cerebral artery compared to the control group (20.9 +/- 3.7 cm/s). Four out of six infants with severe stage of HIE and mean cerebral blood flow velocity of 3 SD above the mean for normal infants at the age of 12 h died and two developed multicystic encephalopathy during the neonatal period. We conclude that severe post-hypoxic increase of mean cerebral blood flow velocity at the age of 12 +/- 2 h is connected with development of severe stage HIE and poor prognosis.
Department of Paediatrics, University of Tartu, Estonia.
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Ilves
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Talvik
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Talvik
D001238:Asphyxia Neonatorum / Q000150:complications / Q000000981:diagnostic imaging*; D001783:Blood Flow Velocity; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D002546:Ischemic Attack, Transient / Q000000981:diagnostic imaging* / Q000209:etiology; D008297:Male; D011379:Prognosis; D012016:Reference Values; D012680:Sensitivity and Specificity; D018608:Ultrasonography, Doppler