Anxiolytic and memory improving effects of moclobemide.
The anxiolytic and memory enhancing effects of moclobemide (p-chloro-N-(2-morphinoethyl)benzamide, CAS 71320-77-9, Ro 11-1163), a reversible and selective monoamine A oxidase inhibitor, were investigated in rats. It was found that the drug had an anxiolytic activity lasting in chronic experiments over 2 weeks. The used dose of the drug did not change animal locomotion in activity cages. In memory experiments (food finding time in maze), moclobemide exerted a favorable effect only after a single administration. In rats with scopolamine-impaired memory, moclobemide attenuated the effects of scopolamine in single and chronic experiments.
Nowakowska
E
E
Department of Pharmacology, University School of Medicine, Poznań, Poland.
Chodera
A
A
Kus
K
K
Rybakowski
J
J
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001549:Benzamides / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects*; D020912:Moclobemide; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D018727:Muscarinic Antagonists / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012601:Scopolamine / Q000494:pharmacology; D013997:Time Factors
D014151:Anti-Anxiety Agents; D001549:Benzamides; D008996:Monoamine Oxidase Inhibitors; D018727:Muscarinic Antagonists; D012601:Scopolamine; D020912:Moclobemide