Comparison of effects of a range of 5-HT receptor modulators on consumption and preference for a sweetened ethanol solution in rats.
This study assessed the effects of a range of serotonergic agents on preference for a slightly sweetened ethanol solution (10% ethanol, 3% glucose) in rats. A two-bottle, free-choice paradigm was used following induction of ethanol consumption. The model used provides a robust and reliable level of ethanol self-administration in normal laboratory rats. Ethanol consumption was significantly and selectively reduced by the 5-hydroxytryptamine-1A (5-HT1A) full agonist 8-OH-DPAT (0.3-1.0 mg/kg) and the 5-HT3 antagonist granisetron (0.1-1.0 mg/kg). Non-specific reductions in fluid consumption were induced by the 5-HT1B agonist RU 24969 (0.1-1.0mg/kg) and the 5-HT2 antagonist ritanserin (1.0-6.0 mg/kg). These studies thus confirm the potential for decreasing ethanol consumption and ethanol preference of 5-HT1A agonists and 5-HT3 antagonists, but failed to find any selective effects for agents acting at 5-HT1B or 5-HT2 receptors.
Research Centre, Laboratorios, Almirall, S.A., Barcelona, Spain.
J S
JS
Silvestre
J M
JM
Palacios
A G
AG
Fernandez
M F
MF
O'Neill
D000428:Alcohol Drinking / Q000503:physiopathology*; D000818:Animals; D008297:Male; D009042:Motivation; D051381:Rats; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin / Q000145:classification / Q000187:drug effects* / Q000502:physiology; D018490:Serotonin Agents / Q000494:pharmacology*; D013649:Taste / Q000187:drug effects* / Q000502:physiology
D011985:Receptors, Serotonin; D018490:Serotonin Agents