The butyrylcholinesterase gene is neither independently nor synergistically associated with late-onset AD in clinic- and community-based populations.
The K variant of the butyrylcholinesterase gene (BChE) was recently found to occur at an increased frequency in a late onset Alzheimer's disease (AD) population, specifically in individuals carrying the epsilon4 allele of the apolipoprotein E (APOE) gene. This suggested synergy between these two genes resulting in an increased risk of late-onset AD. We have genotyped 62 community-based and 329 clinic-based AD cases, and 201 community-based controls at BChE and APOE and find no independent association between BChE and AD nor interaction with APOE in risk for AD in either our clinic or community-based samples.
Roskamp Laboratories, University of South Florida, Tampa 33613, USA.
F
F
Crawford
D
D
Fallin
Z
Z
Suo
L
L
Abdullah
M
M
Gold
A
A
Gauntlett
R
R
Duara
M
M
Mullan
D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D002091:Butyrylcholinesterase / Q000235:genetics*; D003151:Community Health Centers; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D016017:Odds Ratio
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D002091:Butyrylcholinesterase