Effects of glutathione depletors on post-ischemic reperfusion in rat brain.
The present paper reports the effects of GSH depletion (diethylmaleate induced) on partial cerebral ischemia and reperfusion for 7 and 20 days. Our results confirm that there is a paradoxical protective effect of the GSH-depletor and suggest an improved neuronal trophism induced by diethylmaleate treatment.
Institute of Biological Chemistry, Faculty of Pharmacy, University of Catania, Italy.
G
G
Martinez
M L
ML
Carnazza
A
A
Campisi
V
V
Sorrenti
C
C
Di Giacomo
J R
JR
Perez-Polo
A
A
Vanella
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D002545:Brain Ischemia / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism*; D019344:Lactic Acid / Q000378:metabolism; D008297:Male; D008298:Maleates / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D015424:Reperfusion
D008298:Maleates; D019344:Lactic Acid; C014476:diethyl maleate; D005978:Glutathione