[Changes in blood enzyme activity and tumor necrosis factor level in the treatment of experimental pancreatitis with pentoxifylline].
It was established in an acute experiment on rats of Wistar line while an acute pancreatitis simulation using the pancreatic tissue freezing that the level of a tumor necrosis factor (TNF) in a blood serum was maximal in 4 hours from the cold action onset, the activity of amylase and trypsin was heightened and trypsin activity inhibitor (TAI) had lowered. Intraperitoneal application of pentoxifylline in 100 mg/kg dose twice daily have promoted the significant lowering of TNF contents, the amylase and trypsin activity as well, and the TAI concentration increase.
Zaporozhchenko
B S
BS
D000208:Acute Disease; D000818:Animals; D004797:Enzyme-Linked Immunosorbent Assay; D008297:Male; D010195:Pancreatitis / Q000097:blood / Q000188:drug therapy*; D010431:Pentoxifylline / Q000627:therapeutic use*; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D014357:Trypsin / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*; D000516:alpha-Amylases / Q000097:blood*
D010726:Phosphodiesterase Inhibitors; D014409:Tumor Necrosis Factor-alpha; D000516:alpha-Amylases; D014357:Trypsin; D010431:Pentoxifylline