Pathophysiological chemistry of nitric oxide and its oxygenation by-products.
Nitric oxide is not only an important intracellular regulator and cytostatic effector but it is also the starting point for a cascade of physiologically important oxygenation reactions, whose by-products and intermediates have a largely unexplored biochemistry. These new biological discoveries are reshaping our appreciation of the remarkably complex chemistry that underlies it.
Department of Chemistry, University of Wyoming, Laramie, WY 82071-3838, USA. bohle@uwyo.edu
D S
DS
Bohle
D006162:Guanylate Cyclase / Q000502:physiology; D009566:Nitrates / Q000502:physiology; D009569:Nitric Oxide / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000737:chemistry; D052247:Nitric Oxide Synthase Type II; D009589:Nitrogen Oxides / Q000737:chemistry; D010069:Oxadiazoles / Q000494:pharmacology; D011810:Quinoxalines / Q000494:pharmacology; D014664:Vasodilation / Q000502:physiology
C095284:1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one; D009566:Nitrates; D009589:Nitrogen Oxides; D010069:Oxadiazoles; D011810:Quinoxalines; C039642:peroxynitric acid; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; D006162:Guanylate Cyclase