Abolition of anaphylactic shock by Solanum lyratum Thunb.
We investigated the effects of the aqueous extract of Solanum lyratum THUNB. (Solanaceae) (SLAE) on the anaphylactic reactions. SLAE inhibited compound 48/80-induced anaphylactic shock 100% with a dose of 1.0 mg/g body weight (BW). When SLAE was pretreated at concentration ranging from 0.0001-1.0 mg/g BW, the serum histamine levels were reduced in a dose-dependent manner. Passive cutaneous anaphylaxis also inhibited to 69.3% by oral administration of SLAE (0.05 mg/g BW). Moreover, SLAE dose-dependently inhibited the histamine release from the rat peritoneal mast cells (RPMC) by compound 48/80. The level of cAMP in RPMC, when SLAE was added, significantly increased compared with that of normal control. These results indicate that SLAE possess strong antianaphylactic activity.
Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Chonbuk, South Korea.
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B
Kang
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E
Lee
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I
Hong
J
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Lee
H
H
Kim
D000707:Anaphylaxis / Q000097:blood / Q000209:etiology / Q000628:therapy*; D000818:Animals; D000906:Antibodies; D000242:Cyclic AMP / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D006636:Histamine Release / Q000187:drug effects*; D008407:Mast Cells / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D051381:Rats; D017208:Rats, Wistar; D003189:p-Methoxy-N-methylphenethylamine
D000906:Antibodies; D004365:Drugs, Chinese Herbal; D003189:p-Methoxy-N-methylphenethylamine; D000242:Cyclic AMP