Synthesis of diosgenyl alpha-L-rhamnopyranosyl-(1-->2)- [beta-D-glucopyranosyl-(1-->3)]-beta-D-glucopyranoside (gracillin) and related saponins.
Diosgenyl alpha-L-rhamnopyranosyl-(1--2)-[beta-glucopyranosyl-(1--3)]- beta-D-glucopyranoside (gracillin), a monodesmosidic saponin isolated from paris, dioscorea, and costacea species with promising cardiovascular and antitumor activities, was synthesized by stepwise glycosylation.
Li
C
C
State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China.
Yu
B
B
Liu
M
M
Hui
Y
Y
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D002236:Carbohydrate Conformation; D002317:Cardiovascular Agents / Q000737:chemistry / Q000494:pharmacology*; D006031:Glycosylation; D015394:Molecular Structure; D012503:Saponins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013150:Spirostans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D002317:Cardiovascular Agents; D012503:Saponins; D013150:Spirostans; C044934:gracillin