Changes in IGF-1 receptors in the hippocampus of adult rats after long-term adrenalectomy: receptor autoradiography and in situ hybridization histochemistry.
Alteration of insulin-like growth factor-1 (IGF-1) receptor and its mRNA after long-term adrenalectomy (ADX) was studied in the hippocampus by in vitro receptor autoradiography and in situ hybridization histochemistry, respectively. Significantly, decreased levels of IGF-1 receptor and its mRNA was noted in the dentate and CA1-CA4 regions of the hippocampus of the ADX animals, suggesting that the level and expression of IGF-1 receptors in the hippocampus is influenced by adrenal hormones.
Islam
A
A
Department of Clinical Neuroscience and Family Medicine, Geriatric Section, Karolinska Institute, Huddinge University Hospital, B-84, S-141 86 Huddinge, Sweden.
Ayer-LeLievre
C
C
Heigensköld
C
C
Bogdanovic
N
N
Winblad
B
B
Adem
A
A
D000305:Adrenal Cortex Hormones / Q000097:blood; D000315:Adrenalectomy; D000367:Age Factors; D000818:Animals; D016375:Antisense Elements (Genetics); D017209:Apoptosis / Q000502:physiology; D001345:Autoradiography; D001923:Brain Chemistry / Q000502:physiology; D006624:Hippocampus / Q000737:chemistry / Q000166:cytology / Q000378:metabolism*; D017403:In Situ Hybridization; D008297:Male; D009410:Nerve Degeneration / Q000378:metabolism; D018696:Neuroprotective Agents / Q000032:analysis / Q000378:metabolism; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017207:Rats, Sprague-Dawley; D017526:Receptor, IGF Type 1 / Q000032:analysis / Q000235:genetics* / Q000378:metabolism*
D000305:Adrenal Cortex Hormones; D016375:Antisense Elements (Genetics); D018696:Neuroprotective Agents; D012333:RNA, Messenger; D017526:Receptor, IGF Type 1