Dietary zinc oxide in weaned pigs--effects on performance, tissue concentrations, morphology, neutrophil functions and faecal microflora.
The uptake and distribution of zinc in tissues and the effects of 2500 ppm dietary zinc oxide on health, faecal microflora, and the functions of circulating neutrophils were evaluated in weaned pigs. One group was fed a zinc supplement diet and another group was used as a control. All pigs remained healthy throughout the study, but the supplemented animals showed better performance than the controls. The serum zinc values rose rapidly. At autopsy, carried out at the age of 63 days, the zinc concentrations in liver tissue were 4.5 times higher, and in renal tissue two times higher in the supplemented group than in controls (P<0.001). Microscopic examination showed increased lipid accumulation in hepatocytes from supplemented pigs. No effect on the number of excreted Escherichia coli and enterococci per gram faeces or on the functions of circulating neutrophils was observed. Dietary supplementation with 2500 ppm ZnO for up to two weeks after weaning appears to be potentially beneficial in the prevention of postweaning diarrhoea in pigs.
Department of Medicine and Surgery, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala. Marianne.Jensen-Waern@kirmed.slu.se
M
M
Jensen-Waern
L
L
Melin
R
R
Lindberg
A
A
Johannisson
L
L
Petersson
P
P
Wallgren
D000821:Animal Feed; D000818:Animals; D017400:Brachyspira / Q000302:isolation & purification; D002432:Cecum; D003016:Clostridium perfringens / Q000302:isolation & purification; D016983:Enterococcus / Q000302:isolation & purification; D004926:Escherichia coli / Q000302:isolation & purification; D005234:Fatty Liver / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary; D005243:Feces / Q000382:microbiology*; D005260:Female; D005527:Food, Fortified; D006965:Hyperplasia; D007413:Intestinal Mucosa / Q000166:cytology / Q000187:drug effects / Q000473:pathology; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D018482:Muscle, Skeletal / Q000378:metabolism; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D012401:Rotavirus / Q000302:isolation & purification; D013552:Swine / Q000502:physiology*; D013553:Swine Diseases / Q000139:chemically induced / Q000473:pathology; D014018:Tissue Distribution; D014886:Weaning; D015430:Weight Gain / Q000187:drug effects*; D015034:Zinc Oxide / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology*
D015034:Zinc Oxide