Evaluation of the therapeutic effect of pefloxacin in comparison with ampicillin and gentamicin in cirrhotic patients with spontaneous bacterial peritonitis.
OBJECTIVE
Hepatic cirrhosis is a common, chronic disease. Spontaneous bacterial peritonitis (SBP) is a dangerous complication, which must be treated as soon as it has been diagnosed. This usually requires hospitalization of the patient and parenteral antibiotic therapy for 10 to 14 days. The present study was carried out to compare the therapeutic effects of pefloxacin with ampicillin plus gentamicin in the management of SBP.


METHODS
The patients were divided into two groups at random. Group A consisted of nine patients who received parenteral ampicillin plus gentamicin. Group B consisted of thirteen patients who received pefloxacin.


RESULTS
55% of patients in group A and 100% of patients in group B responded to treatment. No major side effects were observed in either of the groups.


CONCLUSIONS
Considering the benefits of oral treatment and the low incidence of side effects of pefloxacin we conclude that this regimen should be the treatment of choice for SBP patients, especially when there is a shortage of hospital beds.
Department of Microbiology and Immunology, Iran University of Medical Sciences, Tehran, Iran.
L A
LA
Rastegar
G
G
Umrani
N
N
Dehbashi
F
F
Malec
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000667:Ampicillin / Q000008:administration & dosage / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001201:Ascites / Q000276:immunology; D005069:Evaluation Studies as Topic; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D008875:Middle Aged; D015366:Pefloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D010538:Peritonitis / Q000150:complications / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D016896:Treatment Outcome
D000890:Anti-Infective Agents; D005839:Gentamicins; D015366:Pefloxacin; D000667:Ampicillin