[Effect of sugar-reducing therapy on renal function in patients with type II diabetes mellitus].
Renal function was examined in 66 proteinura-free patients at the age of 40-67 years having diabetes mellitus (DM) type II for 4-10 years and HbA1c 7% maximum. Non-insulin-dependent DM was found to affect both glomerular and tubulointerstitial renal systems. This was indicated by reduced glomerular filtration, microalbuminuria, hyperenzymuria, high blood and urine levels of beta-2-microglobulin. Administration of glurenorm instead of maninil led to enhancement of glomerular filtration, lowerering of albuminuria, uroenyzmes, beta-2-microglobulin in the blood and urine. Glurenorm is a proper drug in DM type II as it has both sugar-reducing and nephroprotective effects.
Mazurov
V I
VI
Novik
A A
AA
Nagibovich
O A
OA
Romashevskiĭ
B V
BV
Guliaeva
I V
IV
Kurganova
T A
TA
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000503:physiopathology*; D005919:Glomerular Filtration Rate / Q000187:drug effects; D005905:Glyburide / Q000627:therapeutic use*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007668:Kidney / Q000503:physiopathology*; D007677:Kidney Function Tests; D008875:Middle Aged; D013453:Sulfonylurea Compounds / Q000627:therapeutic use*; D001613:beta 2-Microglobulin / Q000378:metabolism
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D013453:Sulfonylurea Compounds; D001613:beta 2-Microglobulin; C010969:gliquidone; D005905:Glyburide