Trisomy 3q11-q29 is recurrently observed in B-cell non-Hodgkin's lymphomas associated with cold agglutinin syndrome.
Three cases of low-grade B-cell non-Hodgkin's lymphoma associated with cold agglutinin syndrome, cytogenetically characterized by partial trisomy 3, are presented in this report. Our data suggest that the long arm of chromosome 3 might be of particular importance in the pathogenesis of this subgroup of lymphomas.
Center for Human Genetics, University of Leuven, Belgium.
L
L
Michaux
J
J
Dierlamm
L
L
Wlodarska
A
A
Criel
A
A
Louwagie
A
A
Ferrant
A
A
Hagemeijer
H
H
Van den Berghe
D000368:Aged; D000369:Aged, 80 and over; D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications* / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000235:genetics*; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000235:genetics*; D008297:Male; D014314:Trisomy / Q000235:genetics*