Principles for the safety evaluation of flavouring substances.
This paper reviews efforts by various organizations to develop principles and procedures for the safety evaluation of flavouring substances. Critical factors considered in safety evaluation of these substances include their level of human intake, ease of metabolism to innocuous end-products and the margin of safety between no-observed-effect levels in animal studies and human intakes. These factors form the basis for the principles and criteria laid out in this paper.
CanTox Inc., Mississauga, Ontario, Canada.
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Munro
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Shubik
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Hall
D000818:Animals; D005421:Flavoring Agents / Q000378:metabolism / Q000592:standards* / Q000633:toxicity; D017408:Guidelines as Topic; D006801:Humans; D019055:No-Observed-Adverse-Effect Level; D011786:Quality Control; D012015:Reference Standards; D013329:Structure-Activity Relationship; D014944:World Health Organization
D005421:Flavoring Agents