Transcription factors and osteoblasts.
Transcription factors play a key role in determination of the fate of the cells in osteoblastic and chondrocytic lineage. A runt family member, Cbfa, is indispensable for osteoblastic differentiation. Sox 9 and scleraxis are involved in the phenotypic expression in chondrocytes and the cells of early stage connective tissues. These transcription factors will give us a clue to unravel interaction of these known and yet unknown transcription factors to fully understand the mechanisms of skeletal cells ' differentiation and regulation of their functions.
Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan. noda.mph@mri.tmd.ac.jp
M
M
Noda
A
A
Nifuji
K
K
Tuji
K
K
Furuya
S
S
Ichiro
Y
Y
Asou
N
N
Kawaguchi
K
K
Yamachita
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000502:physiology; D050659:Core Binding Factor Alpha 1 Subunit / Q000502:physiology; D050658:Core Binding Factor beta Subunit / Q000502:physiology; D006609:High Mobility Group Proteins / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D010006:Osteoblasts / Q000502:physiology*; D055758:SOX9 Transcription Factor; D014157:Transcription Factors / Q000502:physiology*
D051792:Basic Helix-Loop-Helix Proteins; D050659:Core Binding Factor Alpha 1 Subunit; D050658:Core Binding Factor beta Subunit; D006609:High Mobility Group Proteins; D055758:SOX9 Transcription Factor; D014157:Transcription Factors; C503815:Scx protein, mouse; C527933:Sox9 protein, mouse