[Prognostic value of the initial response of serum estradiol levels to stimulation with GnRH analogues in in vitro fertilization].
Studying the value prognostic of the answer of the Estradiol (E2) levels to the stimulation with agonists of GnRH (GnRH-a) during early follicular phase. Retrospective, analytic and comparative study. From January 1, 1993 to December 31, 1995 403 IVF cycles were studied. According to E2 levels after stimulation with GnRH-a four Patterns were assembled. Pattern A (n = 115), B (n = 22), C (n = 11), and D (n = 3). Those was included patients managed in short luteal phase in this study, (FLC) (n = 153) and long luteal phase (FLL) (n = 97) were groups control. The rate of oocyte retrieve was greater in the patterns, A, B, FLC and FLL with respect to the patron D (p = 0.001). The pregnancy rate was higher in A, B, FLC and FLL (25%, 19%, 22% and 25% respectively (p = 0.05). The age was old in C and D and luteal phase with an average of 35 +/- 2 (p = 0.001). The patterns had a better answer, represented by the increment of the estradios (E2) levels response to the GnRH-a action of leuprolide acetate during the early follicular phase they went A and B. We conclude that the early E2 response patterns to leuprolide acetate is the best early prognostic indicator of IVF outcome.
Cabra
R
R
Muñiz
M
M
Jaroslav Stern
J
J
Verez
J R
JR
Gutiérrez Najar
A J
AJ
D000328:Adult; D000704:Analysis of Variance; D004958:Estradiol / Q000097:blood*; D005260:Female; D005307:Fertilization in Vitro; D005498:Follicular Phase; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006801:Humans; D016729:Leuprolide; D008423:Maternal Age; D011247:Pregnancy; D011256:Pregnancy Outcome; D011379:Prognosis; D012189:Retrospective Studies
D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol; D016729:Leuprolide