Synthesis utilizing insoluble polymers: new reactions and small molecules.
It can be argued that solid-phase organic chemistry is the preferred method of preparing screening libraries for lead compound discovery and lead optimization within the pharmaceutical industry. Solid-phase peptide chemistry is the most reliable and general of the synthetic methods available today; however, the purities of products are inadequate for the needs of the current market and the screening departments of pharmaceutical companies. Recent synthetic advances in solid-phase organic chemistry have started to increase the range of chemistry that can be used to prepare 'drug-like' small molecules in library format.
Oxford Diversity, 57 Milton Park, Abingdon, Oxon, OX14 4RX, UK. TBaxter@OA-OD.com
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D002625:Chemistry, Organic; D015195:Drug Design; D055601:Organic Chemistry Phenomena; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D011487:Protein Conformation; D012995:Solubility
D010455:Peptides; D011108:Polymers