Single-dose antibiotic prophylaxis in transurethral resection of the prostate: a prospective randomized trial.
OBJECTIVE
To evaluate the efficacy of single-dose antibiotic prophylaxis in transurethral resection of the prostate (TURP).


METHODS
A total of 139 patients were entered into a prospective randomized trial comparing single-dose antibiotic prophylaxis with no antibiotic before surgery. Twelve patients were excluded because they had significant bacteriuria before surgery (defined as > or = 10(5) bacteria/mL). Of the remaining 127 patients, 62 were allocated to the single-dose group (A) and 65 to the no-antibiotic group (B). All 62 patients in group A received 1 g of ceftriaxone intravenously 1-2 h before surgery with the anaesthetic premedication, the 65 in group B receiving none. Urine cultures were collected post-operatively as the catheter was removed and again 4 weeks after hospitalization.


RESULTS
The incidence of post-operative bacteriuria was statistically significantly different, occurring in five patients (9%) in group A and 16 patients (26%) in group B (Fisher's exact test, one-tail P = 0.009). There was no significant difference between the groups 4 weeks after hospitalization. The overall incidence of bacteriuria post-operatively and 4 weeks after hospitalization was 11 patients (18%) in group A and 22 patients (34%) in group B (P = 0.03).


CONCLUSIONS
Single-dose antibiotic prophylaxis with 1 g of ceftriaxone intravenously is effective in patients undergoing TURP and is recommended for such surgery.
Department of Urology, Kaiser Franz Josef Hospital, Vienna, Austria.
M
M
Scholz
W
W
Luftenegger
H
H
Harmuth
D
D
Wolf
W
W
Höltl
D019072:Antibiotic Prophylaxis / Q000379:methods; D001437:Bacteriuria / Q000517:prevention & control*; D002443:Ceftriaxone / Q000008:administration & dosage*; D002511:Cephalosporins / Q000008:administration & dosage*; D006760:Hospitalization; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D011292:Premedication; D011446:Prospective Studies; D011468:Prostatectomy / Q000009:adverse effects / Q000379:methods*; D011469:Prostatic Diseases / Q000601:surgery*
D002511:Cephalosporins; D002443:Ceftriaxone