Comparative investigation of the long non-coding M-F genome region of wild-type and vaccine measles viruses.
The sequence of the 300 nucleotides region of the measles virus genome was determined that includes a part of the 3'-untranslated region of the matrix (M) gene, the intergenic region and a part of the 5'-untranslated region of the fusion (F) gene [M-F region] for vaccine strain Leningrad-16 and 14 wild-type isolates. The data obtained demonstrate the variability of this long non-coding M-F region. No mutations in this region of the genome were found which seem to be specific for vaccine strains of measles virus (MV).
Heider
A
A
Research Institute of Viral Preparations, Russian Academy of Medical Sciences, Moscow, Russia.
Santibanez
S
S
Tischer
A
A
Gerike
E
E
Tikhonova
N
N
Ignatyev
G
G
Mrazova
M
M
Enders
G
G
Schreier
E
E
D000818:Animals; D001483:Base Sequence; D002522:Chlorocebus aethiops; D004279:DNA, Viral; D016679:Genome, Viral; D006801:Humans; D008458:Measles Vaccine / Q000235:genetics*; D008459:Measles virus / Q000145:classification / Q000235:genetics*; D008969:Molecular Sequence Data; D010802:Phylogeny; D012689:Sequence Homology, Nucleic Acid; D014709:Vero Cells; D014760:Viral Fusion Proteins / Q000235:genetics*; D014763:Viral Matrix Proteins / Q000235:genetics*
D004279:DNA, Viral; D008458:Measles Vaccine; D014760:Viral Fusion Proteins; D014763:Viral Matrix Proteins