Determination of losartan and its degradates in COZAAR tablets by reversed-phase high-performance thin-layer chromatography.
Losartan potassium is an angiotensin II receptor blocker. It has been formulated and marketed as a tablet dosage from (COZAAR). A reversed-phase high-performance thin-layer chromatography method has been validated and shown to be sensitive, efficient, and reliable, and can be used as an excellent alternative to the HPLC stability testing of losartan potassium in COZAAR tablets.
Pharmaceutical Research and Development, Merck Research Laboratories, West Point, PA 19486, USA.
K E
KE
McCarthy
Q
Q
Wang
E W
EW
Tsai
R E
RE
Gilbert
D P
DP
Ip
M A
MA
Brooks
D000959:Antihypertensive Agents / Q000032:analysis* / Q000737:chemistry; D002855:Chromatography, Thin Layer / Q000379:methods*; D019808:Losartan / Q000032:analysis* / Q000737:chemistry; D015394:Molecular Structure; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D000959:Antihypertensive Agents; D019808:Losartan