Squamous cell carcinoma of the skin associated with systemic sclerosis.
BACKGROUND
The coexistence of sclerosis and cancer has been recognized with increasing frequency. However, squamous cell carcinoma of the skin associated with systemic sclerosis is relatively rare.


OBJECTIVE
The mechanisms of malignancy in systemic sclerosis are discussed.


METHODS
An 18-year-old girl with progressive systemic sclerosis is described.


RESULTS
The patient had developed squamous cell carcinoma of the skin on the sclerosed skin of her left leg requiring amputation. The tumor recurred on the distal end of the stump. Local radiotherapy was unsuccessful.


CONCLUSIONS
This report suggests that sclerosis of the skin may manifest a greater risk of developing skin cancers unrelated to chronic injury or scarring of the skin.
Oztürk
M A
MA
Institute of Oncology, Hacettepe University, Ankara, Turkey.
Benekli
M
M
Altundağ
M K
MK
Güler
N
N
D000293:Adolescent; D000671:Amputation, Surgical; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D006801:Humans; D007866:Leg / Q000601:surgery; D007871:Leg Ulcer / Q000473:pathology / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000532:radiotherapy; D012595:Scleroderma, Systemic / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery