Trinucleotide repeat DNA structures: dynamic mutations from dynamic DNA.
Models for the disease-associated expansion of (CTG)n.(CAG)n, (CGG)n.(CCG)n, and (GAA)n.(TTC)n trinucleotide repeats involve alternative DNA structures formed during DNA replication, repair and recombination. These repeat sequences are inherently flexible and can form a variety of hairpins, intramolecular triplexes, quadruplexes, and slipped-strand structures that may be important intermediates and result in their genetic instability.
Center for Genome Research, Institute of Biosciences and Technology, Texas A&M University, Houston 77030-3303, USA.
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D001482:Base Composition; D001483:Base Sequence; D004247:DNA / Q000737:chemistry* / Q000235:genetics*; D004260:DNA Repair; D004261:DNA Replication; D030342:Genetic Diseases, Inborn / Q000235:genetics; D006801:Humans; D008957:Models, Genetic; D008958:Models, Molecular; D009154:Mutation; D009690:Nucleic Acid Conformation; D011995:Recombination, Genetic; D013816:Thermodynamics; D018911:Trinucleotide Repeats
D004247:DNA