Ring opening cross-metathesis on solid support: a combinatorial library synthesis of highly functionalized cyclopentanes.
Ruthenium catalyzed ring opening cross-metathesis of resin-bound bicyclic alkenes with terminal aryl olefins was utilized for the construction of a combinatorial library containing highly functionalized cyclopentane derivatives. The technology described herein represents a convergent method for the diastereospecific synthesis of unique cyclopentane molecular scaffolds useful for exploratory medicinal chemistry.
Sepracor Inc., Marlborough, MA 01752-7231, USA.
J
J
Cao
G D
GD
Cuny
J R
JR
Hauske
D002625:Chemistry, Organic / Q000379:methods; D003517:Cyclopentanes / Q000138:chemical synthesis* / Q000737:chemistry; D016208:Databases, Factual; D007202:Indicators and Reagents; D013058:Mass Spectrometry; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D003517:Cyclopentanes; D007202:Indicators and Reagents