[The effect of gentamycin on immunity in immunodeficiency and the action of immunomodulators].
The effect of 3 and 6 mg/kg gentamicin on the immunity of intact mice and cyclophosphan- and azathioprine-induced immunodeficiency was studied. Gentamicin deepens the severe suppression of antibody genesis against the background of cyclophosphan and azathioprine, inhibits the reaction of GZT in intact mice. The antibiotic does not prevent stimulation of AOK production by methyluracil and prodigiosan, and does not change the effect of immunostimulators on GZT in immunosuppression. Gentamicin has no effect on the phagocytic activity of neutrophils and macrophages in intact animals. The character of the effect of the antibiotic on phagocytosis depends on the genesis of immunosuppression. The effectiveness of gentamicin in experimental infection is maintained in immunosuppression also.
Department of Pharmacology, Bashkir State Medical University, Ufa, Russia.
D D
DD
Sakaeva
D N
DN
Lazareva
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D001379:Azathioprine; D003520:Cyclophosphamide; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D005839:Gentamicins / Q000494:pharmacology*; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007111:Immunity, Cellular / Q000187:drug effects; D007153:Immunologic Deficiency Syndromes / Q000139:chemically induced / Q000276:immunology*; D007166:Immunosuppressive Agents; D008297:Male; D051379:Mice; D010587:Phagocytosis / Q000187:drug effects; D011512:Proteus Infections / Q000276:immunology; D011513:Proteus mirabilis
D000276:Adjuvants, Immunologic; D000900:Anti-Bacterial Agents; D005839:Gentamicins; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D001379:Azathioprine