[Changes in bone mass and in glucose homeostasis in subjects with high spontaneous fluoride intake].
This paper reports metabolic data of 24 women and two men, 44-66 years old, ex-residents in an area of endemic fluorosis close to Bahía Blanca city. Fasting fluoremias of these subjects (0.5 to 9.2 microM) and daily urinary fluoride excretion (> 60 mumoles/day) are characteristics of zones with endemic fluorosis. Bone mineral density (BMD) at the lumbar spine (L2-4 1330 +/- 41 mg/cm2) and femoral neck (1045 +/- 10 mg/cm2) were significantly above average of normal subjects of the same age and sex. A significant correlation was observed between the daily excretion of fluoride and BMD L2-4 (r = 0.43, P < 0.05). The Area Under the Curve of insulin during a standard glucose tolerance test showed an inverse relationship with fluoremia. This observation coincides with experiments published elsewhere indicating that fluoride intake at concentrations 5 microM or greater, inhibits the secretion of insulin.
Laboratorio de Biología Osea, Universidad Nacional de Rosario, Argentina.
M
M
de la Sota
R
R
Puche
A
A
Rigalli
L M
LM
Fernández
S
S
Benassati
R
R
Boland
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000187:drug effects*; D015519:Bone Density / Q000187:drug effects*; D005260:Female; D005459:Fluorides / Q000494:pharmacology*; D006706:Homeostasis; D006801:Humans; D008297:Male; D008875:Middle Aged
D001786:Blood Glucose; D005459:Fluorides