Huntingtin: a single bait hooks many species.
Cloning of the Huntington's disease gene uncovered huntingtin, which is remarkable for its lack of similarity with known proteins despite its large size, approximately 350 kDa. Subsequent experiments established that huntingtin has an as yet unknown function, crucial for embryonic development and neurogenesis. Recent protein trapping to identify huntingtin interactors now reveals that many different prey fall victim to huntingtin bait.
Molecular Neurogenetics Unit, Massachusetts General Hospital, Charlestown 02129, USA. gusella@helix.mgh.harvard.edu
J F
JF
Gusella
M E
ME
MacDonald
D000818:Animals; D006801:Humans; D000071058:Huntingtin Protein; D006816:Huntington Disease / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000502:physiology*; D009687:Nuclear Proteins / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D013045:Species Specificity
C096896:HAP1 protein, human; C086055:HTT protein, human; D000071058:Huntingtin Protein; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins