Rapidly deteriorating polyneuropathy associated with osteosclerotic myeloma responsive to intravenous immunoglobulin and radiotherapy.
Osteosclerotic myeloma is a plasma-cell dyscrasia characterized by osteosclerotic bone lesions, which may be associated with progressive demyelinating polyneuropathy. We describe a 49-year-old patient with rapidly deteriorating polyneuropathy associated with osteosclerotic myeloma, who responded favorably to a combination of intravenous immunoglobulin and radiotherapy.
Department of Neurology, Universitary Hospital 12 de Octubre, Madrid, Spain. jbenitol@meditex.es
J
J
Benito-León
F
F
López-Ríos
F J
FJ
Rodríguez-Martín
S
S
Madero
J
J
Ruiz
D003131:Combined Modality Therapy; D003711:Demyelinating Diseases / Q000209:etiology* / Q000503:physiopathology / Q000532:radiotherapy / Q000628:therapy; D018450:Disease Progression; D006801:Humans; D007146:Immunoglobulin lambda-Chains / Q000032:analysis*; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008159:Lumbar Vertebrae / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009194:Myeloma Proteins / Q000032:analysis*; D014411:Neoplastic Stem Cells / Q000737:chemistry; D009431:Neural Conduction; D010026:Osteosclerosis / Q000209:etiology*; D016878:POEMS Syndrome / Q000150:complications* / Q000175:diagnosis; D010523:Peripheral Nervous System Diseases / Q000209:etiology* / Q000503:physiopathology / Q000532:radiotherapy / Q000628:therapy; D010950:Plasma Cells / Q000737:chemistry; D010954:Plasmacytoma / Q000150:complications* / Q000175:diagnosis; D013125:Spinal Neoplasms / Q000150:complications* / Q000175:diagnosis
D007146:Immunoglobulin lambda-Chains; D016756:Immunoglobulins, Intravenous; D009194:Myeloma Proteins