Frequency of vacA genotypes and cytotoxin activity in Helicobacter pylori associated with low-grade gastric mucosa-associated lymphoid tissue lymphoma.
The vacA genotypes s1,m1 and s1,m2 were detected in 44 and 30% of Helicobacter pylori isolates, respectively, from patients with gastric mucosa-associated lymphoid tissue lymphoma, compared to 26 and 56% of isolates, respectively, from individuals with gastritis. The vacA s1 genotype was significantly associated with, but not predictive of, the presence of vacuolating cytotoxin activity.
Miehlke
S
S
Medical Department I, Technical University, Dresden, Germany. stephan.miehlke@t-online.de
Meining
A
A
Morgner
A
A
Bayerdörffer
E
E
Lehn
N
N
Stolte
M
M
Graham
D Y
DY
Go
M F
MF
D001426:Bacterial Proteins / Q000235:genetics*; D003603:Cytotoxins / Q000378:metabolism*; D005260:Female; D005756:Gastritis / Q000382:microbiology; D005838:Genotype; D016481:Helicobacter Infections / Q000150:complications; D016480:Helicobacter pylori / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity*; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000150:complications / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods; D013274:Stomach Neoplasms / Q000150:complications / Q000382:microbiology*; D014617:Vacuoles / Q000378:metabolism
D001426:Bacterial Proteins; D003603:Cytotoxins; C074689:VacA protein, Helicobacter pylori