Glycoproteins of the human milk fat globule in the protection of the breast-fed infant against infections.
Nonimmunological components in human milk can protect breast-fed infants against infection by microorganisms. The structural and functional characteristics of four such components are discussed. The mucin inhibits binding of S-fimbriated Escherichia coli to bucal epithelial cells; lactadherin prevents symptomatic rotavirus-induced infection; glycoaminoglycans inhibit binding of human immunodeficiency virus gp120 to its host cell CD4 receptor, and oligosaccharides provide protection against several pathogens and their toxins.
Cancer Research Institute of Contra Costa, Walnut Creek, Calif 94596, USA. japer@ibm.net
J A
JA
Peterson
S
S
Patton
M
M
Hamosh
D000595:Amino Acid Sequence; D000818:Animals; D000890:Anti-Infective Agents; D000954:Antigens, Surface / Q000737:chemistry; D001424:Bacterial Infections / Q000517:prevention & control*; D005260:Female; D006017:Glycolipids / Q000737:chemistry / Q000502:physiology*; D006023:Glycoproteins / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D007231:Infant, Newborn; D066292:Lipid Droplets; D008894:Milk Proteins / Q000737:chemistry; D008895:Milk, Human / Q000737:chemistry*; D008969:Molecular Sequence Data; D009077:Mucins / Q000737:chemistry / Q000502:physiology; D014777:Virus Diseases / Q000517:prevention & control*
D000890:Anti-Infective Agents; D000954:Antigens, Surface; D006017:Glycolipids; D006023:Glycoproteins; C098942:MFGE8 protein, human; D008894:Milk Proteins; D009077:Mucins; C110367:milk fat globule