[Hemodynamic effects of amrinone or milrinone in infant after right heart bypass operation].
After right heart bypass operation, dopamine was continuously infused at 5 micrograms/kg/min. The patients had a stable hemodynamic status but relatively low SvO2, low urine output and peripheral insufficiency. Amrinone was continuously infused at 10 micrograms/kg/min in 5 patients (Group A), or milrinone was continuously infused at 0.5 microgram/kg/min in 5 patients (Group M). After infusion of amrinone or milrinone, arterial blood pressure relatively decreased and heart rate relatively increased. But heart work index did not increased. SvO2 relatively increased. Mean pulmonary artery pressure relatively decreased. The administration of amrinone (Group A) produced relatively thrombocytopenia compared with milrinone (Group M). Two patients had supraventricular arrhythmia in Group A. A patient had ventricular arrhythmia and another patient supraventicular arrhythmia. These patients treated using temporary antiarrhythmia drug or temporary pacing. When the patients discharged, they recovered the normal sinus rhythm. In conclusion, after right heart bypass operation in infants, infusion of amrinone or milrinone appears to be effective and safe combining with dopamine.
Okabe
H
H
Department of Cardio-Thoracic Surgery, Kanagawa Children's Medical Center, Yokohama, Japan.
Kaneko
Y
Y
Nagata
N
N
Kobayashi
J
J
Kanemoto
S
S
Ka
H
H
Fuijmoto
J
J
Fuijwara
T
T
D000676:Amrinone / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004298:Dopamine / Q000627:therapeutic use; D018610:Heart Bypass, Right; D006330:Heart Defects, Congenital / Q000503:physiopathology / Q000601:surgery; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D020105:Milrinone; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use*; D011184:Postoperative Period; D011728:Pyridones / Q000627:therapeutic use*
D010726:Phosphodiesterase Inhibitors; D011728:Pyridones; D020105:Milrinone; D000676:Amrinone; D004298:Dopamine