Pharmacological stimulation of arterial chemoreceptors in conscious rats produces differential responses in renal cortical and medullary blood flow.
1. There have been no previously published data regarding intrarenal blood flow distribution in acute whole-body hypoxic hypoxia and/or arterial chemoreceptor stimulation in normoxic mammals. 2. Cortical and medullary blood flows were measured simultaneously before and in response to pharmacological stimulation of peripheral arterial chemoreceptors by i.v. injection of almitrine bismesylate (0.25 mg/kg). 3. Arterial chemoreceptor excitation reduced cortical blood flow but only in innervated kidneys. An effect on medullary blood flow was observed in neither innervated nor denervated kidneys. 4. These data indicate that renal cortical and medullary blood flows react differently to arterial chemoreceptor stimulation.
Ledderhos
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Institute of Physiology, Ernst-Moritz-Arndt-University, Greifswald, Germany. honig@rz.uni-greifswald.de
Gross
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Cowley
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AW
D015765:Almitrine / Q000494:pharmacology; D000818:Animals; D001158:Arteries / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D002628:Chemoreceptor Cells / Q000187:drug effects*; D003714:Denervation; D006339:Heart Rate / Q000187:drug effects; D007668:Kidney / Q000294:innervation; D007672:Kidney Cortex / Q000187:drug effects*; D007679:Kidney Medulla / Q000187:drug effects*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012079:Renal Circulation / Q000187:drug effects; D019141:Respiratory System Agents / Q000494:pharmacology; D013268:Stimulation, Chemical; D014662:Vasoconstrictor Agents / Q000494:pharmacology
D019141:Respiratory System Agents; D014662:Vasoconstrictor Agents; D015765:Almitrine; D009638:Norepinephrine