Rats receiving the slimming agent oleoyl-estrone in liposomes (Merlin-2) decrease food intake but maintain thermogenesis.
Oleoyl-estrone given i.v.--incorporated in liposomes to mimic lipoprotein delivery--(Merlin-2) to normal weight rats, induces a dose-dependent weight loss. Analysis of body composition showed that body protein concentration was preserved and fat stores wasted. The respiratory quotient was consistent with the massive oxidation of body fat, since the diet contained practically no lipid. Appetite was affected by Merlin-2, and thus food intake showed a transient decrease. But oxygen consumption (and basal metabolic rates) was kept practically unchanged at the levels of the controls, i.e. higher than needed to oxidize the food ingested during the weight loss period. Brown adipose tissue uncoupling protein levels were proportionally preserved with a 2-week treatment, but it lost a substantial amount of lipid. In conclusion, Merlin-2 is a slimming agent with considerable potential given its powerful fat-wasting action, since it maintains thermogenesis despite lowered energy intake.
Sanchis
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D
Centre d'Investigació, Laboratoris S.A.L.V.A.T., S.A., Esplugues de Llobregat, Spain.
Balada
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F
Picó
C
C
Grasa
M M
MM
Virgili
J
J
Farrerons
C
C
Palou
A
A
Fernández-López
J A
JA
Remesar
X
X
Alemany
M
M
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D019440:Anti-Obesity Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001067:Appetite Depressants / Q000008:administration & dosage / Q000494:pharmacology*; D001823:Body Composition / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects*; D004337:Drug Carriers; D004353:Drug Evaluation, Preclinical; D004435:Eating / Q000187:drug effects*; D004970:Estrone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D008066:Lipolysis / Q000187:drug effects*; D008081:Liposomes; D009829:Oleic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects; D011506:Proteins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D015431:Weight Loss / Q000187:drug effects
D019440:Anti-Obesity Agents; D001067:Appetite Depressants; D004337:Drug Carriers; D008081:Liposomes; D009829:Oleic Acids; D011506:Proteins; D004970:Estrone; C108709:oleoyl-estrone