Anticonvulsant effects of nimodipine and two novel dihydropyridines (PCA 50922 and PCA 50941) against seizures elicited by pentylenetetrazole and electroconvulsive shock in mice.
In animal models of epilepsy, calcium entry blockers have shown anticonvulsant properties. We studied the antiepileptic effects of nimodipine and two novel dihydropyridines, a calcium antagonist (PCA 50922) and a calcium agonist (PCA 50941), on pentylenetetrazole seizure and maximal electroshock seizure (MES) in mice. Anticonvulsant profile of nimodipine and PCA 50922 was similar to that of clonazepam, but markedly different from that of phenytoin. None of the doses of the PCA 50941 showed anticonvulsant effect.
Department of Pharmacology and Therapeutics, Faculty of Medicine, Universidad Autónoma de Madrid, Spain.
P
P
Zapater
J
J
Javaloy
J F
JF
Román
M T
MT
Vidal
J F
JF
Horga
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D002120:Calcium Channel Agonists / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002998:Clonazepam / Q000627:therapeutic use; D004095:Dihydropyridines / Q000494:pharmacology* / Q000627:therapeutic use*; D004597:Electroshock; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009553:Nimodipine / Q000627:therapeutic use*; D010433:Pentylenetetrazole; D010672:Phenytoin / Q000627:therapeutic use; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy* / Q000209:etiology; D013844:Thiazoles / Q000627:therapeutic use*
D000927:Anticonvulsants; D002120:Calcium Channel Agonists; D002121:Calcium Channel Blockers; D004095:Dihydropyridines; C114963:PCA 50922; D013844:Thiazoles; C084781:PCA 50941; D009553:Nimodipine; D002998:Clonazepam; D010672:Phenytoin; D010433:Pentylenetetrazole