Effect of chronic mitral valve damage on activity of pulmonary rapidly adapting receptors in the rabbit.
1. The effects of acute pulmonary venous congestion on the activity of rapidly adapting receptors (RARs) were determined in intact (control and sham-operated) rabbits and in rabbits 6 and 12 weeks after surgical destruction of the mitral valve. 2. Destruction of the mitral valve increased the mean left atrial pressure (LAP) by approximately 2.6 and 3.8 mmHg, 6 and 12 weeks after surgery, respectively. These changes were accompanied by significant increases in left ventricular weight. The effect of acute increments in LAP on RAR activity was examined against this background of chronic pulmonary venous congestion. 3. In intact control and sham-operated animals RAR activity increased from 48.8 +/- 0.9 to 83. 5 +/- 3.6 and 121.1 +/- 4.7 action potentials min-1 when the LAP was raised by 5 and 10 mmHg, respectively, above control values. Six weeks after surgery only 40 % of RARs were activated in this way. 4. In animals maintained for 12 weeks after surgery, RAR activity at LAPs of 6.6 +/- 1.2 (control), 11.6 +/- 1.2 and 16.6 +/- 1.2 (mmHg) were 35.5 +/- 2.3, 33.8 +/- 14.4 and 34.0 +/- 3.4 action potentials min-1, respectively. These changes were statistically not significant. 5. Slowly adapting receptors (SARs) in the lung showed a small but statistically significant increase in activity when the left atrial pressure was acutely elevated in both intact and mitral valve damaged animals . 6. It is concluded that chronic pulmonary venous congestion resulting from destruction of the mitral valve attenuates the ability of RARs to respond to acute moderate elevations of LAP.
Division of Cardiovascular Medicine, University of California, Davis, CA 95616, USA.
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Gunawardena
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Bravo
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CT
Kappagoda
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D016279:Atrial Function, Left / Q000502:physiology*; D001794:Blood Pressure; D001835:Body Weight; D006339:Heart Rate; D006439:Hemodynamics; D008168:Lung / Q000502:physiology*; D008297:Male; D008465:Mechanoreceptors / Q000502:physiology*; D008943:Mitral Valve / Q000293:injuries / Q000473:pathology / Q000502:physiology*; D008944:Mitral Valve Insufficiency / Q000473:pathology / Q000503:physiopathology*; D009929:Organ Size; D011667:Pulmonary Veins / Q000502:physiology* / Q000503:physiopathology; D011817:Rabbits; D012016:Reference Values