The outcome of patients with hypogammaglobulinemia in infancy and early childhood.
A 10-year prospective cohort study followed the evolution of antibodies in children less than 4 years of age with hypogammaglobulinemia. Three patterns were identified: in group 1, immunoglobulins and antibody production normalized;iin group 2, patients continued to have low IgG levels; and in group 3, IgG levels normalized but antibody levels were transient. Statistical analysis showed that invasive infection or low tetanus antibodies at presentation were associated with the development of significant humoral immunodeficiency.
Division of Immunology/Allergy, Hospital for Sick Children, Toronto, Ontario, Canada.
I
I
Dalal
B
B
Reid
E
E
Nisbet-Brown
C M
CM
Roifman
D000361:Agammaglobulinemia / Q000276:immunology; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D006801:Humans; D017099:IgG Deficiency / Q000276:immunology; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007223:Infant; D008297:Male; D011446:Prospective Studies
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M