Energy expenditure, body composition, and glucose metabolism in lean and obese rhesus monkeys treated with ephedrine and caffeine.
The administration of ephedrine and caffeine (E+C) has been proposed to promote weight loss by increasing energy expenditure and decreasing food intake. We tested this hypothesis in six lean (4-9% body fat) and six mildly to moderately obese (13-44% body fat) monkeys studied during a 7-wk control period, an 8-wk drug treatment period, and a 7-wk placebo period. During the drug treatment period, the monkeys were given ephedrine (6 mg) and caffeine (50 mg) orally three times per day. At the end of each period, a glucose tolerance test was performed, energy expenditure was measured, and body composition was determined. Treatment with E+C resulted in a decrease in body weight in the obese animals (P = 0.06). This loss in weight was primarily the result of a 19% reduction in body fat. Drug treatment also resulted in a decrease in body fat in the lean group (P = 0.05). Food intake was reduced by E+C only in the obese group (P < 0.05). Nighttime energy expenditure was increased by 21% (P < 0.03) in the obese group and 24% (P < 0.01) in the lean group with E+C treatment. Twenty-four-hour energy expenditure was higher in both groups during drug treatment. E+C did not produce systematic changes in glucoregulatory variables, whereas plasma leptin concentrations decreased in both groups with drug treatment. Overall, these results show that E+C treatment can promote weight loss through an increase in energy expenditure, or in some individuals, a combination of an increase in energy expenditure and a decrease in food intake.
Ramsey
J J
JJ
Wisconsin Regional Primate Research Center, University of Wisconsin, Madison 53715-1299, USA.
Colman
R J
RJ
Swick
A G
AG
Kemnitz
J W
JW
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001823:Body Composition / Q000187:drug effects*; D002110:Caffeine / Q000494:pharmacology* / Q000627:therapeutic use; D004435:Eating / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects*; D004809:Ephedrine / Q000494:pharmacology* / Q000627:therapeutic use; D005951:Glucose Tolerance Test; D020738:Leptin; D008253:Macaca mulatta; D008297:Male; D009765:Obesity / Q000188:drug therapy / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D015431:Weight Loss
D001786:Blood Glucose; D020738:Leptin; D011506:Proteins; D002110:Caffeine; D004809:Ephedrine