Reconstruction with free jejunal autograft after circumferential pharyngolaryngectomy: eighty-three cases.
The free jejunal autograft (FJA) has become a common procedure for pharyngeal reconstruction after circumferential pharyngolaryngectomy. In order to evaluate the postoperative outcome and the functional and carcinologic results, we retrospectively reviewed 83 cases of reconstruction with FJA. Fifty-one patients had received no prior radiotherapy, and 25 had received prior radiotherapy for their hypopharyngeal tumor or for another previous primary. Seven patients underwent a secondary reconstruction. In the postoperative course, there were 2 postoperative deaths, 4 graft failures (5%), and 11 salivary fistulas. The median time to removal of the nasogastric tube was 16 days, and to discharge, 23 days. Forty-eight patients received postoperative radiotherapy, with good tolerance. At 1 year postoperatively, 98% of the patients were able to eat a solid or soft diet. The postoperative radiotherapy did not impair the quality of the functional results in a long-term assessment. The vocal results were disappointing. The 3-year survival rate was 40%. The main carcinologic failures (45 patients) were locoregional recurrences (20 patients) and metastasis, which was the cause of death in 34% of the cases. It seems clear that FJA allows one-stage reconstruction and good swallowing rehabilitation, tolerates postoperative radiotherapy, and increases the quality of life in these patients with a poor prognosis.
Department of Head and Neck Surgery, Institut Gustave Roussy, Villejuif, France.
M
M
Julieron
M A
MA
Germain
G
G
Schwaab
P
P
Marandas
J L
JL
Bourgain
P
P
Wibault
B
B
Luboinski
D000293:Adolescent; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002277:Carcinoma / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D002945:Cisplatin / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D007583:Jejunum / Q000637:transplantation*; D007825:Laryngectomy / Q000379:methods*; D007830:Larynx / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010611:Pharyngectomy / Q000379:methods*; D010614:Pharynx / Q000601:surgery*; D012189:Retrospective Studies
D000970:Antineoplastic Agents; D002945:Cisplatin; D005472:Fluorouracil