Differentiation between transmural perioperative myocardial infarction and subendocardial injury after coronary artery bypass grafting using biochemical tests, elaborated by cluster and discriminant analysis.
The aim of this study is to differentiate between transmural perioperative myocardial infarction (T-PMI) and subendocardial perioperative myocardial injury (S-PMI) as a complication of coronary artery bypass grafting (CABG). Seventy-three patients undergoing CABG were followed post operatively by measuring troponin T, CK-MB isoenzyme mass concentration (CK-MB mass), creatine kinase MB isoenzyme activity (CK-MB activity), creatine kinase (CK), alpha hydroxybutyrate dehydrogenase (HBD), and aspartate aminotransferase (AST) at five sampling times. Lacking a proper definition of the gold standard for the diagnosis of perioperative myocardial infarction, a statistical procedure was used. Supported by the cluster analysis method of Ward, patients were assigned to a patient group with a perioperative myocardial infarction (PMI) or a patient group without a PMI (non-PMI) as a confirmation of interpretation of the biochemical results. Using the results of electrocardiogram (ECG) and echocardiography, the PMI patient group was split into a T-PMI patient group and a S-PMI patient group. With discriminant analysis, two canonic discriminant functions were drawn up to differentiate between patients suffering from a T-PMI or S-PMI and non-PMI patients.
Department of Clinical Chemistry, Catharina Hospital, Eindhoven, Netherlands. harff@iaehv.nl
G A
GA
Harff
R W
RW
Jeurissen
J B
JB
Dijkstra
T J
TJ
Rietjens
J P
JP
Schönberger
D001219:Aspartate Aminotransferases / Q000097:blood; D016000:Cluster Analysis; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D003402:Creatine Kinase / Q000097:blood; D003937:Diagnosis, Differential; D016002:Discriminant Analysis; D004699:Endocardium / Q000201:enzymology / Q000293:injuries*; D005260:Female; D006461:Hemolysis; D006801:Humans; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000201:enzymology / Q000209:etiology; D014336:Troponin / Q000097:blood; D020107:Troponin T
D007527:Isoenzymes; D014336:Troponin; D020107:Troponin T; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase