Recovery from circulatory shock in severe primary pulmonary hypertension (PPH) with aerosolization of iloprost.
OBJECTIVE
The treatment of decompensated right ventricular failure with vasodilators is difficult due to reduced systemic pressure and/or ventilation/perfusion (V/Q) mismatch with hypoxemia. In a recent study we demonstrated that inhaled vasodilatory prostanoids may offer a new strategy to achieve pulmonary selective vasodilatation and improvement of right ventricular function. We applied this new approach to a patient with circulatory shock due to primary pulmonary hypertension (PPH), complicated by a pulmonary infiltrate, who did not tolerate intravenous prostacyclin.


METHODS
Case report.


METHODS
Intensive Care Unit (ICU), Medizinische Klinik Giessen, Germany.


METHODS
A 45-year-old woman with PPH presenting with decompensated right heart failure (ascites, pleural effusion), circulatory shock and commencing renal and hepatic failure, despite maximum therapy including the use of catecholamines.


METHODS
Intermittent inhalation of aerosolized iloprost, the stable analogue of prostacyclin, and comparison to inhaled nitric oxide (NO). Subsequent long-term therapy with aerosolized iloprost, 150 microg/day.


RESULTS
In response to inhaled iloprost, pulmonary arterial pressure (PAP) decreased from 65 to 61 mmHg, cardiac index (CI) increased from 1.25 to 1.85 l/min per m2, and pulmonary vascular resistance (PVR) decreased from 2416 to 1549 dyn/s per cm5 while inhaled NO decreased the PVR from 2280 to 1920 dyn/s per cm5 without a decrease in PAP. Both of these interventions increased the arterial pO2 but did not change the systemic arterial pressure. In contrast, intravenous prostacyclin was not tolerated, due to systemic side effects. During repeated inhalations with iloprost, the baseline hemodynamics and gas exchange improved dramatically and renal and liver functions normalized. During 1 year of continued therapy, the clinical status improved very much, concomitant with improved hemodynamics, and the patient has been taken off the transplantation list.


CONCLUSIONS
Inhalation of aerosolized iloprost may offer a new life-saving strategy in near desperate cases of pulmonary hypertension in which intravenous prostacyclin cannot be applied due to severe side effects.
Department of Internal Medicine II, Justus-Liebig-University, Giessen, Germany. horst.olschewski@innere.med.uni-giessen.de
H
H
Olschewski
H A
HA
Ghofrani
D
D
Walmrath
B
B
Temmesfeld-Wollbrück
F
F
Grimminger
W
W
Seeger
D000280:Administration, Inhalation; D000336:Aerosols / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications*; D016285:Iloprost / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D009569:Nitric Oxide / Q000627:therapeutic use; D010100:Oxygen / Q000097:blood; D012769:Shock / Q000188:drug therapy* / Q000209:etiology; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D018497:Ventricular Dysfunction, Right / Q000188:drug therapy* / Q000209:etiology
D000336:Aerosols; D014665:Vasodilator Agents; D009569:Nitric Oxide; D016285:Iloprost; D010100:Oxygen