Developmental toxicity of purified fumonisin B1 in pregnant Syrian hamsters.
The purpose of this study was to characterize the developmental toxicity of fumonisin B1 (FB1), a mycotoxin produced by Fusarium moniliforme, on fetal Syrian hamsters. Fusarium moniliforme has been associated with a variety of diseases in animals and esophageal cancer in humans. Purified FB1 causes leukoencephalomalacia in horses and is hepatocarcinogenic in rats. Fumonisin B1 has been associated with fetal toxicity in rats and mice and has been suggested to be involved in reproductive failure in pregnant sows. Results from a preliminary developmental toxicity study using an aqueous extract of F. moniliforme corn-culture material in hamsters suggested that FB1 was a developmental toxicant. These results were verified using purified FB1. Six groups of ten time-mated female Syrian hamsters were dosed with 0.0-18 mg kg(-1) day(-1) of FB1 by gavage on days 8-12 of gestation and euthanized on day 15. Live fetuses were weighed and examined for gross external and internal abnormalities and skeletal anomalies. Purified fumonisin B1 was shown to cause dose-dependent fetal death and delayed fetal development without causing fetal abnormalities.
Veterinary Medical Diagnostic Laboratory, University of Missouri-Columbia, 65211, USA.
J D
JD
Penner
S W
SW
Casteel
L
L
Pittman
G E
GE
Rottinghaus
R D
RD
Wyatt
D000014:Abnormalities, Drug-Induced / Q000473:pathology*; D000818:Animals; D002264:Carboxylic Acids / Q000008:administration & dosage / Q000494:pharmacology / Q000633:toxicity*; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D005313:Fetal Death / Q000139:chemically induced*; D037341:Fumonisins; D008647:Mesocricetus; D011247:Pregnancy
D002264:Carboxylic Acids; D037341:Fumonisins; C056933:fumonisin B1