Effect of transforming growth factor-beta1 on interleukin-6 secretion in human myoblasts.
Transforming growth factor-beta (TGF-beta) is involved in several autoimmune neurological diseases. It is still unclear whether its local action can be pro-inflammatory or anti-inflammatory in the muscle tissue, because of the few reports on this subject. We have previously shown that human myoblasts secrete interleukin-6 (IL-6) when stimulated with inflammatory cytokine such as interleukin-1beta (IL-1beta) or tumor necrosis factor alpha. In the present report, we show that TGF-beta1 can induce IL-6 production; moreover, costimulation or short term pre-incubation with TGF-beta1 increases IL-1beta effect, while a longer incubation inhibits its action.
Institute of General Pathology, Catholic University, Rome, Italy.
P
P
Mazzarelli
F
F
Scuderi
G
G
Mistretta
C
C
Provenzano
E
E
Bartoccioni
D004357:Drug Synergism; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology; D015850:Interleukin-6 / Q000378:metabolism*; D009132:Muscles / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D013997:Time Factors; D016212:Transforming Growth Factor beta / Q000494:pharmacology*
D007375:Interleukin-1; D015850:Interleukin-6; D016212:Transforming Growth Factor beta