Kainic acid-induced perirhinal cortical seizures in rats.
Seizures induced in rats by kainic acid microinjection into the perirhinal cortex were studied electrophysiologically and behaviorally and compared with known features of seizures following kainic acid injection into the amygdala. Unlike amygdalar seizures, perirhinal cortical seizures did not generalize to become limbic seizures but rather spread to sensorimotor cortex to become manifest as motor seizures. Perirhinal cortical seizures also required larger kainic acid doses for provocation and were briefer.
Department of Neurosurgery, University of Kagoshima, Faculty of Medicine, Sakuragaoka 8-35-1, Kagoshima 890, Japan. imamuras@med6.kufm.kagoshima-u.ac.jp
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S
Imamura
S
S
Tanaka
H
H
Tojo
S
S
Fukumoto
K
K
Uetsuhara
J
J
Kuratsu
M
M
Takigawa
D000679:Amygdala / Q000503:physiopathology; D000818:Animals; D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced / Q000503:physiopathology*; D018690:Excitatory Amino Acid Agonists; D007608:Kainic Acid; D008297:Male; D008845:Microinjections; D009044:Motor Cortex / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D013003:Somatosensory Cortex / Q000503:physiopathology*
D018690:Excitatory Amino Acid Agonists; D007608:Kainic Acid