Acute hyponatremic encephalopathy after a cerebrovascular accident.
A 66-year-old hypertensive male with acute intracerebral hemorrhage developed acute hyponatremic coma 3 days after the addition of enalapril and a combination of amiloride and a thiazide diuretic to his hypotensive regimen. The patient recovered consciousness and serum sodium normalized 2 days after fluid restriction and withdrawal of both medications. Three weeks later, upon inadvertent reinstitution of enalapril and indapamide, severe hyponatremic encephalopathy promptly recurred; recovery was again rapid following fluid restriction and withdrawal of both medications. This temporal relationship establishes the thiazide diuretic or the angiotensin converting enzyme inhibitor or both as the cause of the profound symptomatic hyponatremia in this patient. Results of simultaneous serum and urine osmolality assays on several occasions were consistent with a decrease in free water clearance, a result of either increased antidiuretic hormone (ADH) secretion or potentiation of its peripheral action, and thiazide-induced natriuresis. The use of a thiazide diuretic in the presence of either of these aberrations of ADH homeostasis most likely explains the profound and rapid development of hyponatremia. Drug-induced disturbances in serum osmolality are a potentially reversible cause of deterioration of the mental state in a patient with an acute cerebrovascular accident.
Department of Internal Medicine, Al Ain Hospital, United Arab Emirates.
N A
NA
Moussa
A R
AR
Osman
T M
TM
Yahya
D000368:Aged; D000584:Amiloride / Q000627:therapeutic use; D001581:Benzothiadiazines; D002490:Central Nervous System / Q000187:drug effects; D002543:Cerebral Hemorrhage / Q000150:complications*; D003128:Coma / Q000139:chemically induced*; D004232:Diuretics; D004656:Enalapril / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007010:Hyponatremia / Q000139:chemically induced*; D007190:Indapamide / Q000627:therapeutic use; D008297:Male; D009994:Osmolar Concentration; D012964:Sodium / Q000097:blood; D049993:Sodium Chloride Symporter Inhibitors / Q000627:therapeutic use; D014667:Vasopressins / Q000502:physiology; D014867:Water / Q000502:physiology
D001581:Benzothiadiazines; D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D014867:Water; D014667:Vasopressins; D004656:Enalapril; D000584:Amiloride; D012964:Sodium; D007190:Indapamide