[Intravascular malignant B-cell lymphomatosis with renal glomerular involvement: a case].
We report a case of intravascular malignant lymphomatosis observed in a 71 year-old male and characterised by the presence of a proteinuria in relation to the specific intraglomerular localisation. This malignant lymphoma, usually of the B phenotype, is rare and affects predominantly the central nervous system and the skin. Neoplastic cells home selectively to endothelium. Histological renal infiltration is frequent but a glomerular localisation, with proteinuria, is rare. The mechanism whereby lymphocytes home to endothelium cells is unclear but it could be related to the expression of lymphocyte-endothelium adhesion molecules. When present the nephrotic syndrome is associated with minimal change disease.
Service de néphrologie, CHG, La Beauchée, St-Brieuc.
C
C
Charasse
R
R
Boulahrouz
S
S
Le Moal
J
J
Bousser
A
A
Pasquiou
P
P
Le Cacheux
K S
KS
Ang
P
P
Simon
M P
MP
Ramée
D000368:Aged; D002448:Cell Adhesion; D004730:Endothelium, Vascular / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology*; D016393:Lymphoma, B-Cell / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D014411:Neoplastic Stem Cells / Q000473:pathology; D009404:Nephrotic Syndrome / Q000209:etiology; D011507:Proteinuria / Q000209:etiology; D019043:Vascular Neoplasms / Q000150:complications / Q000175:diagnosis / Q000473:pathology*