The uncoupling effect of some psychotropic drugs on oxidative phosphorylation in rat liver mitochondria.
In the present study an attempt to detect influence of some psychotropic drugs on oxidative phosphorylation has been made. Relanium and melipramine were used in the experiments. They are among tranquilizer and antidepressant drug groups respectively. It was shown that both drugs increased the rate of oxygen consumption and displayed uncoupling properties. Mitochondrial respiration raised up slowly after drug addition in the presence of succinate or beta-oxybutyrate as oxidized substrates. If concentration of relanium and melipramine exceeded 1.2 and 0.8 mM respectively the rate of oxygen consumption began to decrease. There was a small reply on addition of ADP in the presence of drugs. At the same time relanium and melipramine decreased respiration rate if they were added at the state 3. It was shown that the drugs increased conductivity of bimolecular phospholipid membranes.
Medical Scientific & Production Complex Biotics, Moscow, Russia. yarosl@biotic.dol.ru
N M
NM
Burbenskaya
Y R
YR
Nartsissov
L M
LM
Tsofina
I A
IA
Komissarova
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002458:Cell Fractionation; D003975:Diazepam / Q000494:pharmacology*; D004553:Electric Conductivity; D007099:Imipramine / Q000494:pharmacology*; D008051:Lipid Bilayers; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D019802:Succinic Acid / Q000378:metabolism; D014475:Uncoupling Agents / Q000494:pharmacology*
D008051:Lipid Bilayers; D011619:Psychotropic Drugs; D014475:Uncoupling Agents; D000255:Adenosine Triphosphate; D019802:Succinic Acid; D007099:Imipramine; D003975:Diazepam