Immunoreactive renin concentrations in healthy children from birth to adolescence.
We establish normative data for immunoreactive renin concentration in serum of healthy children. In a retrospective study, surplus sera of 281 healthy children, aged 0-18 years, were collected from the laboratory. The determinations were performed with a commercially available two-site immunoradiometric assay. Functional sensitivity was 4.0 mU/l, inter-assay and intra-assay variance were 7.0-18.3% and 3.8-7.5%, respectively. In umbilical cord and during the first 4 days of life, renin concentrations (geometric mean) were significantly higher (P < 0.05) than in older infants and children [umbilical cord: 155.2 mU/l; newborn infants (2-4 days of life): 90.9; newborn infants (5-7 days of life): 32.5; 2 weeks-3 months: 40.8; 4 months-1 year: 54.5; 1-3 years: 46.3; 3-5 years: 48.5; 5-7 years: 51.6; 7-11 years: 38.5; 11-15 years: 37.7; 15-18 years: 31.9]. Newborn infants delivered by Caesarian section had significantly lower renin concentrations in umbilical cord than those delivered vaginally (P < 0.02). Considering the methodological advantages and disadvantages of plasma renin activity and renin concentration assays, renin measurement was at least as valuable and accurate as plasma renin activity determination.
Krüger
C
C
Division of Endocrinology, Hospital for Children and Adolescents, University of Erlangen-Nürnberg, Erlangen, Germany.
Rauh
M
M
Dörr
H G
HG
D000293:Adolescent; D000375:Aging / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D006801:Humans; D015592:Immunoradiometric Assay; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012016:Reference Values; D012083:Renin / Q000097:blood* / Q000276:immunology; D012189:Retrospective Studies
D012083:Renin