The nucleus: a target site for parathyroid hormone-related peptide (PTHrP) action.
It is becoming increasingly apparent that parathyroid hormone-related peptide (PTHrP) modulates cellular function in a dual mode of action: first, by binding and activating its cognate cell surface G-protein-coupled receptor and, second, by direct intracellular effects following translocation to the nucleus and/or nucleolus of the target cell. Little is presently known about the mechanisms and events that determine the timing and degree of PTHrP nuclear translocation or the role it may serve in normal or dysregulated cellular function. Clarifying the nuclear actions of PTHrP would add significantly to our present understanding of this protein as a signaling molecule during embryonic development and as an oncoprotein whose expression in many tumors correlates with increased tumor aggressiveness and propensity for metastasis.
Nguyen
M T
MT
Department of Medicine, S.M.B.D.-Jewish General Hospital, and Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada.
Karaplis
A C
AC
D000595:Amino Acid Sequence; D000818:Animals; D002466:Cell Nucleolus / Q000502:physiology; D002467:Cell Nucleus / Q000502:physiology*; D003593:Cytoplasm / Q000502:physiology; D006801:Humans; D008969:Molecular Sequence Data; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins