Urokinase receptor genotypes in colorectal cancer.
A previous study has reported a high frequency of rare alleles of the urokinase-type plasminogen activator receptor (uPAR) in a set of 15 colorectal cancer (CRC) cell lines. Our study investigated uPAR gene variation in 92 CRC patients and in tumour DNA from a subset of 69 patients using the PLAUR-IVS3 marker located in an intron of this gene. The overall distribution of the marker alleles in the patients did not differ significantly from a set of 105 controls. A pairwise analysis of individual allele frequencies showed, however, that the common allele 147 was significantly decreased (P = 0.027) and allele 149 was significantly increased (P = 0.033) in the patients. These results may indicate an effect of uPAR gene variation in CRC carcinogenesis and encourages further examination of this marker in an independent series of patients.
Division of Molecular Medicine, John Curtin School of Medical Research, Australian National University, Canberra, ACT. Maija.Corish@anu.edu.au
M
M
Kohonen-Corish
J
J
Young
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Chenevix-Trench
W F
WF
Doe
D000483:Alleles; D001483:Base Sequence; D015179:Colorectal Neoplasms / Q000235:genetics*; D017931:DNA Primers; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D019656:Loss of Heterozygosity; D008969:Molecular Sequence Data; D011956:Receptors, Cell Surface / Q000235:genetics*; D055293:Receptors, Urokinase Plasminogen Activator; D014407:Tumor Cells, Cultured
D017931:DNA Primers; C524898:PLAUR protein, human; D011956:Receptors, Cell Surface; D055293:Receptors, Urokinase Plasminogen Activator