Cytogenetic analysis of a parachordoma.
We report the cytogenetic and histopathological findings in a 7-year-old female child with an intranasal tumor that is most consistent with a parachordoma. Karyotypic analysis of the tumor revealed clonal numerical and structural chromosome abnormalities. Seven cells displayed recurrent changes: der(2)t(2;4), del(3q), and the loss of chromosomes 9, 10, 20, and 22. Four cells showed a loss of chromosome 17. To the best of our knowledge, these are the first clonal chromosome abnormalities described in parachordoma.
Département de Pathologie, Centre de Recherche Pédiatrique, Hôpital Sainte-Justine, Montréal, Québec, Canada.
F
F
Tihy
P
P
Scott
P
P
Russo
M
M
Champagne
J C
JC
Tabet
N
N
Lemieux
D002648:Child; D002817:Chordoma / Q000235:genetics* / Q000473:pathology / Q000628:therapy / Q000648:ultrastructure; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007621:Karyotyping; D008854:Microscopy, Electron; D009669:Nose Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy / Q000648:ultrastructure; D014178:Translocation, Genetic