The correlation of telomerase and IL-10 with leukemia transformation in a mouse model of chronic lymphocytic leukemia (CLL).
Telomerase activity is upregulated in activated and malignant lymphocytes. We studied the correlation of telomerase and IL-10 to leukemia transformation in the NZB mouse model of human chronic lymphocytic leukemia (CLL). Telomerase levels increased from early to late leukemic stages, likewise IL-10 gene expression levels increased with the leukemic progression. The inverse relationship of telomerase and IL-10 levels to the survival of NZB mice was also established. Our data suggested that telomerase and IL-10 were involved in transformation in the murine model of CLL and the detection of telomerase activities might be of value in the prediction of CLL progression.
Peng
B
B
Department of Pathology, New Jersey Medical School, Newark 07103, USA.
Zhang
M
M
Sun
R
R
Lin
Y C
YC
Chong
S Y
SY
Lai
H
H
Stein
D
D
Raveche
E S
ES
D000367:Age Factors; D000818:Animals; D001402:B-Lymphocytes / Q000201:enzymology / Q000276:immunology / Q000378:metabolism; D018956:CD5 Antigens / Q000032:analysis; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D004195:Disease Models, Animal; D016753:Interleukin-10 / Q000096:biosynthesis* / Q000235:genetics; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000201:enzymology* / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D008814:Mice, Inbred NZB; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000032:analysis; D012333:RNA, Messenger / Q000032:analysis; D019098:Telomerase / Q000096:biosynthesis*; D014407:Tumor Cells, Cultured
D018956:CD5 Antigens; D009687:Nuclear Proteins; D012333:RNA, Messenger; D016753:Interleukin-10; D019098:Telomerase