Oxidative stress status and antioxidant status are apparently not related to carotenoid status in healthy subjects.
Several lines of evidence suggest that carotenoids may have a beneficial effect on health as a result of their antioxidant properties. In addition to beta-carotene, five other carotenoids are recovered in noticeable amounts from human plasma and tissues. Although the effect of beta-carotene on in vivo lipid peroxidation has been documented, few data are available on the effects of the other carotenoids. We evaluated the ability of the main human carotenoids to reduce lipid peroxidation by determining the correlations between plasma carotenoid concentration and plasma antioxidant capacity (in 79 healthy volunteers) and between carotenoid status and breath pentane excretion (in a subgroup of 24 subjects). Carotenoid intake was assessed by means of a 3-day food recall. Carotenoid status was evaluated by measurement of beta-carotene, lycopene, lutein/zeaxanthin, and alpha-carotene in plasma and buccal mucosal cells. Antioxidant status was evaluated by measurement of the total antioxidant capacity of the plasma. Oxidative stress status was evaluated by breath pentane measurements. Food recall data and the carotenoid concentrations in plasma and buccal mucosal cells showed that the subjects had normal carotenoid intake and normal carotenoid status. The total antioxidant capacity of the plasma was not related to the concentration of any specific carotenoid. The level of expired air pentane was not related to the carotenoid status of the subjects. These results show that normal concentrations of carotenoids in plasma and tissues are not correlated with these clinical markers of antioxidant and oxidative stress status.
Borel
P
P
INRA, Université d'Auvergne, Laboratoire de Nutrition Humaine, Clermont-Ferrand, France.
Grolier
P
P
Boirie
Y
Y
Simonet
L
L
Verdier
E
E
Rochette
Y
Y
Alexandre-Gouabau
M C
MC
Beaufrere
B
B
Lairon
D
D
Azais-Braesco
V
V
D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D002338:Carotenoids / Q000378:metabolism*; D005247:Feeding Behavior; D006801:Humans; D008297:Male; D018384:Oxidative Stress
D000975:Antioxidants; D002338:Carotenoids