Synthesis, structural characterization and antimicrobial studies of 2,4-pentanedione derivatives. Part I.
The title compounds have been synthesized in good yields by the interaction of 2,3,4-pentanetrione-3-oxime with ethanedithioamide in 1:1, 1:2, and 2:2 mole proportions. The structures of these compounds have been elucidated from its physico-chemical and spectral data and by correlation with well-known products. Preliminary screening of these compounds for biological activity against several microorganisms has indicated that they are selective growth inhibitors of Mycobacterium tuberculosis in particular.
Varadarajan
A
A
Department of Chemistry, Institute of Science, Mumbai, India.
Utekar
S S
SS
Malve
S P
SP
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010422:Pentanones / Q000138:chemical synthesis* / Q000494:pharmacology; D012545:Schiff Bases / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000890:Anti-Infective Agents; D010422:Pentanones; D012545:Schiff Bases