The role of chemotherapy in polymorphonuclear phagocytosis in pneumonia.
The efficacy of the host defense system is a determining factor for the outcome of antimicrobial events in infected patients. The neutrophil granulocyte plays a key role in the lung's defense against bacterial invasion and in the absence of a sufficient attraction of functionally intact neutrophils in the lung, following bacterial challenge, severe pulmonary infection may result. The involvement of phagocytes in pneumonia is well known: infiltration of lung parenchyma by neutrophils occurs within a short time in response to infection and is followed by an influx of monocytes. We investigated the effects of antimicrobial therapy in pneumonia on polymorphonuclear neutrophil (PMN) phagocytosis.
Piatti
G
G
Institute of Respiratory Tract Diseases, Milan, Italy.
Gazzola
T
T
Allegra
L
L
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002176:Candida albicans / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology*; D010587:Phagocytosis / Q000187:drug effects*; D018410:Pneumonia, Bacterial / Q000188:drug therapy* / Q000276:immunology*; D013183:Sputum / Q000382:microbiology
D000900:Anti-Bacterial Agents