CA 125 elevations in patients with malignant lymphomas.
Circulating CA 125 serum levels were measured in 60 patients with several hematological malignancies. Using 35 U/ml as cutoff level, elevated CA 125 concentrations were found in 3 of 18 patients with acute leukemia, 1 of 5 patients with chronic myelocytic leukemia, 2 of 9 patients with Hodgkin's lymphoma and in 14 of 28 patients with non-Hodgkin's lymphoma. None of the healthy control group had CA 125 serum levels above 35 U/ml. In patients with malignant lymphoma, elevated CA 125 serum concentrations were associated with abdominal involvement (p < 0.01). 15 of 19 patients with abdominal tumor masses had CA 125 concentrations above 35 U/ml, but only 1 of 18 patients with supradiaphragmatic involvement. Serial determinations of CA 125 were performed in 3 patients with malignant lymphoma during chemotherapy. Disease regression was associated with decreasing CA 125 serum levels. Thus, CA 125 may be a useful indicator of abdominal involvement in patients with malignant lymphoma. Moreover, serial CA 125 measurement may be of value in monitoring response to chemotherapy in these patients.
Department of Gynecology and Obstetrics, University of Erlangen-Nuremberg, Erlangen, Germany.
T
T
Fehm
E
E
Beck
T
T
Valerius
M
M
Gramatzki
W
W
Jäger
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D018394:CA-125 Antigen / Q000097:blood*; D005260:Female; D006689:Hodgkin Disease / Q000097:blood; D006801:Humans; D007938:Leukemia / Q000097:blood; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood; D008223:Lymphoma / Q000097:blood* / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000473:pathology; D008297:Male; D008875:Middle Aged
D014408:Biomarkers, Tumor; D018394:CA-125 Antigen