Meningeal myeloma in the absence of systemic disease, and as the initial feature of disease progression.
We describe a 60-year-old man with stage IIA myeloma, who despite achieving a systemic remission after C-VAMP, progressed with isolated meningeal myeloma. Meningeal involvement in myeloma is a rare complication with a poor prognosis.
Mount Vernon Centre for Cancer Treatment, Northwood, Middlesex, UK.
L J
LJ
Somers
B
B
Shaw
B E
BE
Lyn
A M
AM
McMillan
P
P
Mahendra
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000188:drug therapy / Q000473:pathology; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D003520:Cyclophosphamide / Q000008:administration & dosage; D018450:Disease Progression; D004317:Doxorubicin / Q000008:administration & dosage; D017809:Fatal Outcome; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007146:Immunoglobulin lambda-Chains / Q000032:analysis; D007278:Injections, Spinal; D008297:Male; D008577:Meningeal Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D008727:Methotrexate / Q000008:administration & dosage; D008775:Methylprednisolone / Q000008:administration & dosage; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy / Q000628:therapy; D009194:Myeloma Proteins / Q000032:analysis; D009367:Neoplasm Staging; D012272:Ribs / Q000473:pathology; D014750:Vincristine / Q000008:administration & dosage
D007074:Immunoglobulin G; D007146:Immunoglobulin lambda-Chains; D009194:Myeloma Proteins; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D008775:Methylprednisolone; D008727:Methotrexate