[Diffusion-weighted MR tomography: navigated multi-shot SE-EPI technique for clinical use].
OBJECTIVE
Evaluation of a navigated multi-shot SE EPI sequence for routine clinical use in MR diffusion imaging.


METHODS
We compared a multi-shot SE EPI sequence with the conventional SE sequence as well as with a single-shot SE EPI sequence on a standard 1.5 Tesla MR-scanner (ACS-NT, Philips Medical Systems) with a conventional gradient system (10 mT/m). Image quality and the reproducibility of the apparent diffusion coefficient were analysed with phantoms and with healthy volunteers. The diffusion coefficients of different brain areas were determined in a group of twenty volunteers.


RESULTS
The multi-shot SE EPI sequence showed considerably shorter measurement times and smaller motion artifacts than the SE sequence and was less sensitive to susceptibility artifacts than the single-shot version. The reproducibility of the diffusion coefficients was better than 10%.


CONCLUSIONS
The navigated multi-shot SE technique is more practicable and meaningful than the SE and the single-shot SE EPI techniques on a standard 1.5 Tesla MR-scanner with a conventional gradient system. In our opinion it is now the best method for diffusion imaging and should be preferred in clinical use. The determination of diffusion coefficients yields reliable results and characteristic values for different tissue can be obtained.
Mürtz
P
P
Radiologische Klinik, Universität Bonn. muertz@imsdd.meb.uni-bonn.de
Flacke
S
S
Träber
F
F
Keller
E
E
Gieseke
J
J
Folkers
P
P
Schild
H H
HH
D000328:Adult; D001921:Brain / Q000033:anatomy & histology*; D001927:Brain Diseases / Q000175:diagnosis*; D001932:Brain Neoplasms / Q000175:diagnosis; D002544:Cerebral Infarction / Q000175:diagnosis; D017352:Echo-Planar Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008962:Models, Theoretical; D019047:Phantoms, Imaging; D013223:Statistics as Topic