New options for diagnosing and treating acromegaly.
Insulin-like growth factor 1 (IGF-1) is the final pathway of the growth hormone cascade, and is a better clinical measure of acromegaly than growth hormone itself. In patients with acromegaly, medical treatment with a somatostatin analog normalizes growth hormone and IGF-1 levels and produces clinical improvement quickly.
Division of Endocrinology and Metabolism, University of Michigan Medical Center, Ann Arbor, USA.
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D000172:Acromegaly / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D000328:Adult; D015415:Biomarkers; D005260:Female; D013006:Growth Hormone / Q000378:metabolism; D006727:Hormone Antagonists / Q000627:therapeutic use; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D013004:Somatostatin / Q000031:analogs & derivatives
D015415:Biomarkers; D006727:Hormone Antagonists; D013004:Somatostatin; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone