Aging and immunoglobulin isotype patterns in oral tolerance.
In the present review we address oral tolerance as an important biological phenomenon and discuss how it is affected by aging. Other factors such as frequency of feeding and previous digestion of the antigen also seem to influence the establishment of oral tolerance. We also analyze immunoglobulin isotypes of specific antibodies formed by tolerant and immunized animals of different ages submitted to different conditions of oral antigen administration. Isotypic patterns were studied as a parameter for assessing the pathways of B and T cell interactions leading to antibody production.
Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
A M
AM
Faria
S M
SM
Ficker
E
E
Speziali
J S
JS
Menezes
B
B
Stransky
B A
BA
Verdolin
W M
WM
Lahmann
V S
VS
Rodrigues
N M
NM
Vaz
D000375:Aging / Q000276:immunology* / Q000502:physiology; D000818:Animals; D007108:Immune Tolerance / Q000276:immunology* / Q000502:physiology; D007132:Immunoglobulin Isotypes / Q000032:analysis*; D051379:Mice; D009092:Mucous Membrane
D007132:Immunoglobulin Isotypes