Perinatal influence of Chlorella vulgaris (E-25) on hepatic drug metabolizing enzymes and lipid peroxidation.
This study evaluates the potential for the perinatal transfer of active constituents and/or metabolites of Chlorella vulgaris (E-25) via modulating the hepatic level of drug metabolizing enzymes and lipid peroxidation. E-25 (100, 300 or 500 mg/kg b.w./day) induced a significant increase in the hepatic levels of glutathione S-transferase (GST) and sulfhydryl (-SH) in fetal and neonatal systems after 14 days treatment to gestating or lactating mice. E-25 (500 mg/kg b.w./day)-modulated inhibition of cytochrome b5 (Cyt. b5), cytochrome P-450 (Cyt. P-450) and malondialdehyde (MDA) level was observed in the fetal and neonatal hepatic tissue following the transplacental or translactational exposure. The observed modulation in the levels of hepatic drug metabolizing enzymes and lipid peroxidation suggest the chemopreventive potential of E-25 via perinatal passage of active constituents and/or metabolites.
Singh
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Human Genetics Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Singh
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Bamezai
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D000818:Animals; D000831:Animals, Newborn; D016588:Anticarcinogenic Agents; D002708:Chlorella; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D015786:Cytochromes b5 / Q000378:metabolism; D005260:Female; D005333:Fetus; D005982:Glutathione Transferase / Q000378:metabolism; D007774:Lactation; D015227:Lipid Peroxidation; D008099:Liver / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D008862:Microsomes, Liver / Q000201:enzymology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
D016588:Anticarcinogenic Agents; D008315:Malondialdehyde; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; D005982:Glutathione Transferase