[Fatal acute liver failure: a rare complication of exertion-induced heat stroke].
Liver injury is a well-known complication of exertional heat stroke. However severe acute irreversible liver dysfunction is rarely associated. Persistent centrolobular hepatocellular necrosis without any regeneration remains very uncommon. We report a case of fatal acute liver failure occurring after exertional heat stroke. Despite the conventional symptomatic treatment, especially active cooling, the patient experienced multiple organ failure with brain death 6 days after his admission. In this case, a chronic treatment with neuroleptic and anticholinergic agents may be considered as a predisposing factor.
Département d'anesthésie-réanimation, hôpital Saint-Roch, Nice, France.
C
C
Ichai
J F
JF
Ciais
H
H
Hyvernat
Y
Y
Labib
P
P
Fabiani
D
D
Grimaud
D000328:Adult; D001778:Blood Coagulation Disorders / Q000209:etiology / Q000503:physiopathology; D003128:Coma / Q000209:etiology; D017809:Fatal Outcome; D018883:Heat Stroke / Q000150:complications*; D006801:Humans; D017114:Liver Failure, Acute / Q000209:etiology*; D008297:Male; D005082:Physical Exertion; D012206:Rhabdomyolysis / Q000209:etiology