A new model of renal microvascular injury.
The vascular endothelial injury with its consequent activation is actively involved in inflammation and promotion of a procoagulant state, which are likely to be of major importance in the pathogenesis of various disorders, including renal thrombotic microangiopathy. This study briefly reviews the consequences of glomerular endothelial cell injury or activation, as shown by recent experimental data.
Nangaku
M
M
Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Japan. mnangaku-tky@umin.ac.jp
Shankland
S J
SJ
Couser
W G
WG
Johnson
R J
RJ
D058186:Acute Kidney Injury / Q000503:physiopathology*; D000818:Animals; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007678:Kidney Glomerulus / Q000098:blood supply* / Q000473:pathology; D008833:Microcirculation / Q000503:physiopathology