An AB block copolymer of oligo(methyl methacrylate) and poly(acrylic acid) for micellar delivery of hydrophobic drugs.
An AB block copolymer of oligo(methyl methacrylate) (oMMA) and poly(acrylic acid) (PAAc) has been synthesized. The block copolymer forms micelles in an aqueous medium, as confirmed by a fluorescence probe technique using pyrene. Doxorubicin hydrochloride was incorporated into the micelle and the release profile of doxorubicin hydrochloride was investigated. Slow and prolonged release of doxorubicin hydrochloride from the micelle was observed. The AB block copolymer micelle can be useful for prolonged mucosal drug delivery of hydrophobic drugs.
Bioengineering Department, University of Washington, Seattle 98195, USA.
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T
Inoue
G
G
Chen
K
K
Nakamae
A S
AS
Hoffman
D000180:Acrylic Resins / Q000737:chemistry*; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000378:metabolism; D003692:Delayed-Action Preparations; D004317:Doxorubicin / Q000737:chemistry / Q000378:metabolism; D016503:Drug Delivery Systems; D005456:Fluorescent Dyes / Q000032:analysis; D008823:Micelles; D019904:Polymethyl Methacrylate / Q000737:chemistry*; D011721:Pyrenes / Q000032:analysis; D013050:Spectrometry, Fluorescence
D000180:Acrylic Resins; D000903:Antibiotics, Antineoplastic; D003692:Delayed-Action Preparations; D005456:Fluorescent Dyes; D008823:Micelles; D011721:Pyrenes; C006903:carbopol 940; D004317:Doxorubicin; D019904:Polymethyl Methacrylate; C030984:pyrene