Distribution of free D-amino acids in tissues and body fluids of vertebrates.
Reports on the distribution, metabolism and origins of free D-amino acids in vertebrate tissues and body fluids are reviewed. The transient emergence of D-aspartic acid during the development of brain and peripheral organs or early stages of life is reported. D-Serine in brain is postulated to be a potentiator for the N-methyl-D-aspartate (NMDA) receptor. Some D-amino acid concentrations in human serum, such as D-Ser and D-Ala, are suggested to correlate with damage to renal function.
Imai
K
K
Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Fukushima
T
T
Santa
T
T
Homma
H
H
Huang
Y
Y
Sakai
K
K
Kato
M
M
D000409:Alanine / Q000378:metabolism*; D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism*; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D012694:Serine / Q000378:metabolism*; D013237:Stereoisomerism; D014714:Vertebrates / Q000378:metabolism*
D016194:Receptors, N-Methyl-D-Aspartate; D001224:Aspartic Acid; D012694:Serine; D000409:Alanine