Gene therapy for lung cancer.
Gene therapy has received considerable attention and some speculation as to its value. Although few patients have been treated, the preliminary results of the phase I lung cancer gene therapy clinical trials are very promising. Clinically relevant basic research in the molecular pathogenesis and immunology of lung cancer is progressing. As improved vector technologies are developed, new opportunities will be available to initiate lung cancer gene therapy trials that are based on a more detailed understanding of lung cancer biology. In conclusion, although important biologic and technical questions remain unanswered, recent research suggests that gene therapy will have a profound impact on lung cancer treatment.
Dubinett
S M
SM
University of California at Los Angeles/Wadsworth Pulmonary Immunology Laboratory, Division of Pulmonary and Critical Care Medicine, USA.
Miller
P W
PW
Sharma
S
S
Batra
R K
RK
D000818:Animals; D019496:Cancer Vaccines / Q000627:therapeutic use; D003131:Combined Modality Therapy; D015316:Genetic Therapy / Q000379:methods; D005822:Genetic Vectors; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D008175:Lung Neoplasms / Q000235:genetics / Q000276:immunology / Q000628:therapy*
D019496:Cancer Vaccines