Dysphagia in patients with inclusion body myositis.
OBJECTIVE
Inclusion body myositis (IBM) is an inflammatory myopathy with a 40% reported incidence of dysphagia. A protracted course, refractory to medical therapy, frequently leads to consultation with an otolaryngologist for dysphagia management. We studied the incidence, symptoms, and mechanisms of dysphagia in patients with IBM.


METHODS
Retrospective study of medical records and self-reported follow-up survey; dysphagia is defined as difficulty in swallowing.


METHODS
Twenty-two patients with biopsy-proven IBM.


RESULTS
The rate of dysphagia was more than 80% (16 of 19), twice as high as previously reported. Progressive dysphagia was associated with a significantly worse functional class. Relevant management guidelines are established, including the timing for appropriate surgical intervention.


CONCLUSIONS
Progressive dysphagia may signify more aggressive IBM or an episodic worsening in status. Recognition of the disease manifestations will afford proper patient management. Informed otolaryngologists can have a favorable impact on the dysphagia associated with IBM.
Department of Otolaryngology and Communicative Disorders, Cleveland Clinic Foundation, Ohio 44195, USA.
S M
SM
Houser
L H
LH
Calabrese
M
M
Strome
D000203:Activities of Daily Living; D001706:Biopsy; D003680:Deglutition Disorders / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D018979:Myositis, Inclusion Body / Q000150:complications* / Q000473:pathology; D012017:Referral and Consultation; D012189:Retrospective Studies; D011795:Surveys and Questionnaires