Early detection and intervention in schizophrenia.
During the course of schizophrenia, symptoms tend to increase at the highest rate during the first 5 years of the disease. Moreover, 10% of suicides by schizophrenic patients occur within the first 10 years of schizophrenia being diagnosed. These facts emphasize the importance of early intervention to improve the course of the disease before further deterioration. The use of psychosocial interventions and drug management programmes, in addition to maintenance antipsychotic medication, reduces the risk of psychotic relapse. Continuity of care from inpatient to outpatient treatment also significantly improves outcome, largely as a result of better drug compliance. It appears, however, that the addition of a behavioural family intervention alone to a standard programme offers little additional benefit. The benefits of intervention programmes last only as long as the programme, and patients should continue with such intensive treatment strategies for at least the duration of the critical phase. Under these circumstances, very mild psychotic complaints may be recognized at an early stage so that treatment can begin even earlier, further increasing the chance of an optimal long-term outcome. Further studies of early intervention and relapse prevention are required to support these findings.
Department of Psychiatry, Academic Medical Centre, University of Amsterdam, The Netherlands.
D H
DH
Linszen
P M
PM
Dingemans
M E
ME
Lenior
W F
WF
Scholte
L
L
de Haan
M J
MJ
Goldstein
D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001521:Behavior Therapy; D003131:Combined Modality Therapy; D005196:Family Therapy; D006801:Humans; D010348:Patient Care Team; D011569:Psychiatric Status Rating Scales; D012008:Recurrence; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D013405:Suicide / Q000523:psychology; D016896:Treatment Outcome; D000092864:Suicide Prevention
D014150:Antipsychotic Agents