Generation and screening of synthetic receptor libraries.
Efficient methods for the preparation of combinatorial libraries of receptors have been reported recently and, in most cases, these have led to the identification of host-like molecules that bind a particular substrate selectively. Dynamic libraries of macrocycles have also been synthesised that could open the way to a new selection approach to receptors and catalysts.
de Miguel
Y R
YR
Cambridge Centre for Molecular Recognition, University Chemical Laboratory, UK. jkms@cam.ac.uk
Sanders
J K
JK
D000595:Amino Acid Sequence; D002625:Chemistry, Organic / Q000379:methods; D008958:Models, Molecular; D019151:Peptide Library; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*; D011956:Receptors, Cell Surface / Q000737:chemistry*; D018160:Receptors, Cytoplasmic and Nuclear / Q000737:chemistry*; D011955:Receptors, Drug / Q000737:chemistry*
D019151:Peptide Library; D010455:Peptides; D011956:Receptors, Cell Surface; D018160:Receptors, Cytoplasmic and Nuclear; D011955:Receptors, Drug