Orbital lymphoma of mucosa-associated lymphoid tissue in a patient with rheumatoid arthritis.
A 75-year-old male with rheumatoid arthritis complained of proptosis of the left eye. On examination, 6-mm left proptosis was seen. A hyperemic and swollen optic disc was visible in the left fundus. Laboratory test results showed positive rheumatoid factor. Computed tomography and magnetic resonance imaging showed a mass lesion in the left orbit. Histopathologic study of the excised specimen revealed centrocyte-like cells and lymphoplasmocytoid cells. Immunohistochemical study showed positive staining of CD 20 (B cells) and lambda light chain (immunoglobulin). The combination of rheumatoid arthritis and lymphoma of mucosa-associated lymphoid tissue in the orbit, as demonstrated in our patient, is rare.
Nagaki
Y
Y
Department of Ophthalmology, Toyama Medical and Pharmaceutical University, Sugitani, Japan.
Hayasaka
S
S
Kitagawa
K
K
Maeda
Y
Y
D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000175:diagnosis; D001706:Biopsy; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D018442:Lymphoma, B-Cell, Marginal Zone / Q000150:complications* / Q000175:diagnosis / Q000532:radiotherapy; D008279:Magnetic Resonance Imaging; D008297:Male; D009918:Orbital Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000532:radiotherapy; D014057:Tomography, X-Ray Computed