[Letter-by-letter alexia after left hemispheral lesion without hemianopsia nor callosal involvement. 2 cases].
We describe two patients suffering from a letter-by-letter reading following an infarct in the left posterior cerebral artery's territory. Unlike most of the verbal alexics, this strategy was particularly fast and effective. Two other features distinguished these patients from verbal alexics: the absence of hemianopia and the sparing of the corpus callosum. A study of the reading of letters and words by each hemisphere was performed. In the first case, the left hemisphere was unable to identify any letter or word. The visual stimuli did not activate the visual word form, not the system which normally recognize letters. However, this latter could be activated by the information transmitted by the right hemisphere via the corpus callosum. In the second case, the left hemisphere could, as well as the right one, identify all the letters. On the other hand, identification of words was impaired, and did not improve when the duration of the visual presentation increased. The left hemisphere, unable to access to the visual word form, could not decipher letter-by-letter. One hypothesis is that the left visual working memory was reduced, and could not store more than one letter. The right hemisphere deciphered the words sequentially, and transmitted the information to the left systems which recognize the letter. These two observations confirm that letter-by-letter alexia could result exclusively from the destruction, of the inaccessibility of the visual word-form. A lesion of the left ventral occipito-temporal structures is sufficient, and a left hemianopia, or a splenial lesion is not absolutely necessary. The sparing of the corpus callosum allows a fast transmission to the left phonological processing, if the left systems recognizing letters are efficient.
Clinique Neurologique, Hôpital Beaujon, Clichy.
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Verstichel
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Cambier
D000368:Aged; D000369:Aged, 80 and over; D002544:Cerebral Infarction / Q000150:complications*; D003337:Corpus Callosum / Q000503:physiopathology; D003937:Diagnosis, Differential; D004410:Dyslexia / Q000175:diagnosis; D004411:Dyslexia, Acquired / Q000175:diagnosis / Q000209:etiology*; D006423:Hemianopsia / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged