Molecular mechanisms of TNF receptor-mediated signaling.
Tumor necrosis factor alpha (TNF alpha) is a proinflammatory cytokine involved in a variety of physiological and pathological conditions. During the past several years substantial progress has been made toward a better understanding of how a single cytokine is able to exert obviously opposing effects (e.g., apoptosis and growth). This review focuses on the recently discovered TNF-receptor (TNFR)-associated proteins involved in the activation of intracellular signal-transduction cascades. It explains which classes of proteins have been described so far and how these factors are able to mediate different biological functions after TNFR activation.
Department of Gastroenterology and Hepatology, Medizinische Hochschule Hannover, Germany.
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NP
Malek
J
J
Pluempe
S
S
Kubicka
M P
MP
Manns
C
C
Trautwein
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D006801:Humans; D008024:Ligands; D008565:Membrane Proteins / Q000502:physiology*; D017434:Protein Structure, Tertiary; D018124:Receptors, Tumor Necrosis Factor / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D008024:Ligands; D008565:Membrane Proteins; D018124:Receptors, Tumor Necrosis Factor