Immune responses in ileostomy fluid and serum after oral cholera vaccination of patients colectomized because of ulcerative colitis.
The capacity of an oral inactivated B-subunit-whole-cell cholera vaccine to induce immune responses in patients colectomized due to ulcerative colitis was studied. Two doses of vaccine induced significant mucosal immunoglobulin A (IgA) antibody responses in ileostomy fluid against cholera toxin in 14 of 15 (93%) patients and against whole vibrios in 9 of 15 (60%) cases. The serological responses were lower (but not significantly) than those observed in healthy Swedish volunteers. Increased IgA antitoxin levels were found in ileostomy fluid as late as 2 years after vaccination.
Departments of Medical Microbiology and Immunology, Göteborg University, Göteborg, Sweden.
J
J
Kilhamn
H
H
Brevinge
A M
AM
Svennerholm
M
M
Jertborn
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood / Q000276:immunology; D002771:Cholera / Q000276:immunology / Q000517:prevention & control*; D002772:Cholera Toxin / Q000009:adverse effects / Q000276:immunology*; D022121:Cholera Vaccines / Q000009:adverse effects / Q000276:immunology*; D003082:Colectomy; D003093:Colitis, Ulcerative / Q000097:blood / Q000276:immunology* / Q000601:surgery; D005260:Female; D006801:Humans; D007081:Ileostomy; D008297:Male; D008875:Middle Aged; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000009:adverse effects / Q000276:immunology*
D000907:Antibodies, Bacterial; D022121:Cholera Vaccines; D014614:Vaccines, Synthetic; D002772:Cholera Toxin