Antiproliferative sesterterpenes from the Caribbean sponge Cacospongia cf. linteiformis.
Two new sesterterpenes, lintenolides F (6 a, b) and G (7 a, b), were isolated from the Caribbean sponge Cacospongia cf. linteiformis. Their stereostructures were determined using spectroscopic and chemical methods. The new compounds (6 a, b and 7 a, b) and the related compounds lintenolides A-E (1 a, b-5 a, b), previously isolated from the sponge, exhibited antiproliferative activity on four cell lines.
Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, Italy.
A
A
Carotenuto
E
E
Fattorusso
V
V
Lanzotti
S
S
Magno
R
R
Carnuccio
T
T
Iuvone
D000818:Animals; D002417:Cattle; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D002851:Chromatography, High Pressure Liquid; D004730:Endothelium, Vascular; D005354:Fibrosarcoma; D008264:Macrophages; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D009000:Monocytes; D011161:Porifera / Q000737:chemistry*; D054830:Sesterterpenes; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D054830:Sesterterpenes; D013729:Terpenes