ATP synthase--past and future.
This paper gives an overview of a lecture scheduled for the opening of the 10th European Bioenergetics Congress. In this lecture I plan to first reflect on the accomplishments of some of the individuals who were involved in research on the ATP synthase during the past 50 years. Then I will give a brief view of the present information about rotational catalysis by the ATP synthase. This will be followed by a discussion of some results from my laboratory that call for additional experimentation. Finally I will direct attention to other questions about the ATP synthase that should be addressed in future studies.
Molecular Biology Institute, University of California at Los Angeles 90077-1570, USA. pdboyer@ucla.edu
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D000818:Animals; D002384:Catalysis; D006801:Humans; D006180:Proton-Translocating ATPases / Q000378:metabolism
D006180:Proton-Translocating ATPases