Indole-2-carboxamide inhibitors of human liver glycogen phosphorylase.
Hoover
D J
DJ
Departments of Cardiovascular and Metabolic Diseases Medicinal Chemistry, Exploratory Medicinal Biology, and Cardiovascular and Metabolic Diseases Biology, Central Research Division, Pfizer Inc., Groton, Connecticut 06340, USA.
Lefkowitz-Snow
S
S
Burgess-Henry
J L
JL
Martin
W H
WH
Armento
S J
SJ
Stock
I A
IA
McPherson
R K
RK
Genereux
P E
PE
Gibbs
E M
EM
Treadway
J L
JL
D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002460:Cell Line; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000517:prevention & control; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006003:Glycogen / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007211:Indoles / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008099:Liver / Q000166:cytology / Q000201:enzymology* / Q000378:metabolism; D051379:Mice; D008820:Mice, Obese; D006005:Phosphorylases / Q000037:antagonists & inhibitors*; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D001786:Blood Glucose; D004791:Enzyme Inhibitors; D007004:Hypoglycemic Agents; D007211:Indoles; D011994:Recombinant Proteins; D006003:Glycogen; D006005:Phosphorylases