Affective disorder associated with a balanced translocation involving chromosome 14 and 18.
We report a case of a women with psychiatric illness that includes bipolar disorder who has a karyotype of 46,XX,t(14;18)(q11.2;q22.1). The region on chromosome 18 that is involved in the translocation has been implicated in other families through linkage and association studies as possibly containing a gene for bipolar illness.
Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Philadelphia, PA 19107, USA. J_Overhauser@lac.jci.tju.edu
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J
Overhauser
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Berrettini
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Rojas
D000328:Adult; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics*; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics*; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods; D007621:Karyotyping; D019964:Mood Disorders / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics*