Lower density of A1 adenosine receptors in nucleus reticularis thalami in rats with genetic absence epilepsy.
The possible involvement of the adenosinergic modulatory system in the pathogenesis of absence seizures was investigated in genetic absence epilepsy rats from Strasbourg (GAERS). Using in vitro quantitative autoradiography, the distribution of A1 adenosine receptors and adenosine uptake sites in the brain of GAERS was studied and compared to that of control animals. An area-specific lower density of A1 receptors (15% decrease) was detected in reticular (nRT) and anterior ventral (AV) thalamic nuclei as well as basal ganglia in the brains of GAERS animals compared with control animals. Since adenosine exerts an anti-oscillatory effect on the thalamic nuclei by suppressing (via A1 receptors) excitatory as well as inhibitory neurotransmitter release, the impairment in A1 receptor density seen here, especially in nRT, could be implicated in the thalamic rhythmicity underlying spike and wave discharges present in this absence epilepsy model.
Ekonomou
A
A
Department of Physiology, School of Medicine, University of Patras, Greece.
Angelatou
F
F
Vergnes
M
M
Kostopoulos
G
G
D000241:Adenosine / Q000031:analogs & derivatives / Q000493:pharmacokinetics / Q000494:pharmacology; D000345:Affinity Labels; D000818:Animals; D001345:Autoradiography; D001923:Brain Chemistry / Q000187:drug effects / Q000235:genetics; D004832:Epilepsy, Absence / Q000235:genetics* / Q000378:metabolism*; D008297:Male; D058915:Purinergic P1 Receptor Antagonists; D051381:Rats; D018047:Receptors, Purinergic P1 / Q000235:genetics* / Q000378:metabolism*; D013787:Thalamic Nuclei / Q000378:metabolism*; D013868:Thioinosine / Q000031:analogs & derivatives / Q000493:pharmacokinetics / Q000494:pharmacology
D000345:Affinity Labels; D058915:Purinergic P1 Receptor Antagonists; D018047:Receptors, Purinergic P1; C027513:N(6)-cyclohexyladenosine; D013868:Thioinosine; C001789:4-nitrobenzylthioinosine; D000241:Adenosine