The role of chemotherapy in polymorphonuclear phagocytosis in pneumonia.
The efficacy of the host defense system is a determining factor for the outcome of antimicrobial events in infected patients. The neutrophil granulocyte plays a key role in the lung's defense against bacterial invasion and in the absence of a sufficient attraction of functionally intact neutrophils in the lung, following bacterial challenge, severe pulmonary infection may result. The involvement of phagocytes in pneumonia is well known: infiltration of lung parenchyma by neutrophils occurs within a short time in response to infection and is followed by an influx of monocytes. We investigated the effects of antimicrobial therapy in pneumonia on polymorphonuclear neutrophil (PMN) phagocytosis.
Institute of Respiratory Tract Diseases, Milan, Italy.
G
G
Piatti
T
T
Gazzola
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L
Allegra
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002176:Candida albicans / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology*; D010587:Phagocytosis / Q000187:drug effects*; D018410:Pneumonia, Bacterial / Q000188:drug therapy* / Q000276:immunology*; D013183:Sputum / Q000382:microbiology
D000900:Anti-Bacterial Agents