Adenovirus core protein V is delivered by the invading virus to the nucleus of the infected cell and later in infection is associated with nucleoli.
A 'west-Western' blotting procedure indicates that adenovirus core protein V is linked to the capsid via protein VI. Double-labelling techniques employing confocal microscopy and immunofluorescence suggest that this linkage is disrupted following infection and penetration of the host cell. Protein V enters the nucleus presumably still in association with the other core proteins attached to the virus genome. Later in infection protein V rapidly accumulates in the nucleus in close association with nucleoli.
School of Biomedical Sciences, University of St Andrews, UK.
D A
DA
Matthews
W C
WC
Russell
D000260:Adenoviruses, Human / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport; D002466:Cell Nucleolus / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D011817:Rabbits; D014758:Viral Core Proteins / Q000235:genetics / Q000378:metabolism*
D014758:Viral Core Proteins