Protein NMR extends into new fields of structural biology.
Advances in protein NMR have opened new doors for the understanding of macromolecular structure and interactions. Isotope-labelling approaches have extended the size limit for structure determination, the mapping of protein-ligand interactions is now widely used and has led to a new drug discovery approach, pathways of protein folding processes can be followed, and the structures of molecules from membranes can be determined.
Biomolecular Structure Unit, Glaxo Wellcome Research & Development, Gunnels Wood Road, Stevenage, SG1 2NY, UK. rc8817@ggr.co.uk
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Cooke
D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry*
D011506:Proteins