Role of plasma osmolality in the delayed onset of thermal cutaneous vasodilation during exercise in humans.
To elucidate the role of increased plasma osmolality (Posmol), which occurs during exercise in the regulation of cutaneous vasodilation (CVD) during exercise, we determined the relationship between the change in esophageal temperature (DeltaTes) required to elicit CVD (DeltaTes threshold for CVD) and Posmol during light and moderate exercise (30 and 55% of peak oxygen consumption, respectively) and passive body heating. Then we compared the relationship with the data obtained in our previous study [A. Takamata, K. Nagashima, H. Nose, and T. Morimoto. Am. J. Physiol. 273 (Regulatory Integrative Comp. Physiol. 42): R197-R204, 1997], in which we determined the relationships during passive body heating following isotonic (0.9% NaCl) or hypertonic (2 or 3% NaCl) saline infusions in the same subjects. Posmol values at 5 min after the onset of exercise were 287.5 +/- 0.9 mosmol/kgH2O during light exercise and 293.0 +/- 1.2 mosmol/kgH2O during moderate exercise. Posmol just before passive body heating was 289.9 +/- 1.4 mosmol/kgH2O. The DeltaTes threshold for CVD was 0.09 +/- 0.05 degrees C during light exercise, 0.31 +/- 0. 09 degrees C during moderate exercise, and 0.10 +/- 0.05 degrees C during passive body heating. The relationship between the DeltaTes threshold for CVD and Posmol was shown to be on the same regression line both during exercise and during passive body heating with or without infusions [A. Takamata, K. Nagashima, H. Nose, and T. Morimoto. Am. J. Physiol. 273 (Regulatory Integrative Comp. Physiol. 42): R197-R204, 1997]. Our data suggest that the elevated body core temperature threshold for CVD during exercise could be the result of increased Posmol induced by exercise and is not due to reduced plasma volume or the intensity of the exercise itself.
Takamata
A
A
Department of Physiology, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto 602-0841, Japan.
Nagashima
K
K
Nose
H
H
Morimoto
T
T
D000328:Adult; D001831:Body Temperature; D001833:Body Temperature Regulation; D004947:Esophagus; D015444:Exercise / Q000502:physiology*; D006358:Hot Temperature; D006801:Humans; D008297:Male; D009994:Osmolar Concentration; D010101:Oxygen Consumption; D005082:Physical Exertion / Q000502:physiology*; D012039:Regional Blood Flow; D012867:Skin / Q000098:blood supply*; D014664:Vasodilation / Q000502:physiology*