Lipoprotein alterations in patients with HIV infection: relation with cellular and humoral immune markers.
In order to determine lipid abnormalities in serum in HIV-infected patients and their relation with humoral and cellular immunological changes. Ninety HIV-infected patients without acute inflammatory or malignant disease have been studied. Thirty healthy HIV-negative subjects constituted the control group. As compared with controls, patients with CD4 + lymphocytes > 400 x 10(6)/l had higher triglycerides and lower high density lipoprotein (HDL)-cholesterol and apolipoprotein (apo)-A1. Lipoprotein comparison by groups of patients according to CD4 + cell counts showed a decrease of HDL-cholesterol in patients with CD4 + cells < or = 200 x 10(6)/l. When CD4 + lymphocyte counts were < 50 x 10(6)/l, total and very low density lipoprotein (VLDL)-triglycerides and VLDL-cholesterol were increased and HDL and low density lipoprotein (LDL)-cholesterol and apo-A1 were decreased. Interferon (IFN)-alpha, beta2-microglobulin and tumor necrosis factor (TNF)-alpha were correlated positively with total and VLDL-triglycerides and negatively with HDL-cholesterol. In conclusion, lipoprotein changes in patients with HIV-infection are related with humoral and cellular immune markers. A decrease of HDL-cholesterol and apo-A1 and an increase of triglyceride levels could be considered as markers of disease progression.
Fernández-Miranda
C
C
Service of Internal Medicine, Hospital Universitario, 12 de Octubre, Madrid, Spain.
Pulido
F
F
Carrillo
J L
JL
Larumbe
S
S
Gómez Izquierdo
T
T
Ortuño
B
B
Rubio
R
R
del Palacio
A
A
D000328:Adult; D000917:Antibody Formation / Q000276:immunology; D015415:Biomarkers / Q000032:analysis; D018791:CD4 Lymphocyte Count; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D016898:Interferon-alpha / Q000097:blood; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis; D001613:beta 2-Microglobulin / Q000032:analysis
D015415:Biomarkers; D016898:Interferon-alpha; D008074:Lipoproteins; D014409:Tumor Necrosis Factor-alpha; D001613:beta 2-Microglobulin