The roles of hepatocyte growth factor/scatter factor and met receptor in human cancers (Review).
The protein product of c-met proto-oncogene, Met, is a tyrosine kinase receptor for the hepatocyte growth factor (HGF), also known as the scatter factor (SF). HGF/SF-Met signaling has multifunctional effects on mammalian cells. These include stimulation or inhibition of cellular proliferation, promotion of cell movement, invasion into extracellular matrix, and induction of glandular/tubular morphogenesis by epithelial cells. There is a substantial body of experimental evidence that supports the oncogenic role of HGF/SF-Met signaling pathways. This is putatively mediated by autocrine or paracrine mechanisms that promote tumor cell growth, invasion and angiogenesis. We review the evidence that HGF/SF and Met receptor play significant roles in the pathogenesis and biology of human cancers.
Ontario Cancer Institute and University of Toronto, Toronto, Ontario M5G 2M9, Canada.
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D000818:Animals; D002471:Cell Transformation, Neoplastic; D017228:Hepatocyte Growth Factor / Q000096:biosynthesis / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology*; D009389:Neovascularization, Pathologic; D000090063:Proto-Oncogene Mas; D019859:Proto-Oncogene Proteins c-met / Q000096:biosynthesis / Q000502:physiology*; D015398:Signal Transduction
C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D017228:Hepatocyte Growth Factor; D019859:Proto-Oncogene Proteins c-met