Kalman filtering-aided time-resolved solid-surface room temperature phosphorimetry for simultaneous determination of anthracyclines in solution.
Daunorubicin, doxorubicin and epirubicin react with EuIII to form complexes which exhibit analytically useful room temperature phosphorescence (RTP). The RTP features of the three complexes are similar and the RTP spectra completely overlap. However, their three phosphorescence decay rates are different, and these differences were utilized to analyse the time-resolved RTP data by Kalman filtering. Simultaneous quantification of all three complexes is demonstrated and a method is proposed for the simultaneous determination of the three anthracyclines in mixtures by RTP optosensing. The analytical errors observed are within +/- 5%.
Department of Analytical and Food Chemistry, Faculty of Science of Vigo, University of Vigo, Spain.
F
F
Alava-Moreno
M J
MJ
Valencia-González
M E
ME
Díaz-García
D000903:Antibiotics, Antineoplastic / Q000032:analysis*; D049449:Luminescence; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted; D013057:Spectrum Analysis / Q000379:methods
D000903:Antibiotics, Antineoplastic