Atrial septal defect and pregnancy: a retrospective analysis of obstetrical outcome before and after surgical correction.
OBJECTIVE
To describe the obstetrical outcome and long-term cardiac follow-up of a group of patients who had surgery for atrial septal defect repair before pregnancy and a group who underwent pregnancy before surgical correction.


METHODS
Retrospective.


METHODS
Public Institution.


METHODS
Eighty women (mean age 20.15 +/- 4.5 years) complaining of atrial septal defect, 60 of which had surgical correction before pregnancy and subsequently had 115 pregnancies, and 20 of which underwent pregnancy before the correction of cardiac defect and subsequently had 48 pregnancies.


METHODS
Surgical correction of atrial septal defect: 49 by open heart technique (13 with cardiopulmonary bypass, 36 with light hypothermic circulatory arrest), 11 by closed heart techniques.


RESULTS
Patients who underwent pregnancy before surgery had an increased incidence of miscarriage, pre-term delivery and cardiac symptoms during pregnancy. Patients operated before pregnancy required more frequently cesarean section and pharmacological therapy. The frequency of stillbirths, malformations in the offspring and long-term cardiac complications were similar in both groups.


CONCLUSIONS
Surgical correction of atrial septal defect before pregnancy is recommended even in case of apparently well compensated hemodinamic situation for the low rate of surgical complications in spite of the higher incidence of obstetrical problems in case of medical therapy alone.
Actis Dato
G M
GM
Department of Ginecology and Obstetrics, University of Turin.
Rinaudo
P
P
Revelli
A
A
Actis Dato
A
A
Punta
G
G
Centofanti
P
P
Cavaglià
M
M
Barbato
L
L
Massobrio
M
M
D000328:Adult; D002315:Cardiopulmonary Bypass; D002585:Cesarean Section; D005260:Female; D006344:Heart Septal Defects, Atrial / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000175:diagnosis* / Q000601:surgery; D012189:Retrospective Studies; D012307:Risk Factors; D019616:Thoracic Surgical Procedures / Q000379:methods