Tyrosine hydroxylase and insulin-like growth factor II but not insulin are adjacent in the teleost species barramundi, Lates calcarifer.
In humans, the genes encoding tyrosine hydroxylase (TH), insulin and insulin-like growth factor II (IGF-II) form an extremely tight linkage group on chromosome 11p15. Characterisation of the homologous genomic region of a teleost, the barramundi Lates calcarifer, revealed tight linkage of the TH and IGF-II genes, and the absence of the gene encoding insulin.
Centre for Molecular Biotechnology, School of Life Science, Queensland University of Technology, Brisbane, Australia.
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D000818:Animals; D002874:Chromosome Mapping / Q000662:veterinary*; D003001:Cloning, Molecular; D005091:Exons / Q000235:genetics; D007328:Insulin / Q000235:genetics*; D007335:Insulin-Like Growth Factor II / Q000235:genetics*; D007438:Introns / Q000235:genetics; D010473:Perciformes / Q000235:genetics*; D016133:Polymerase Chain Reaction / Q000662:veterinary; D015183:Restriction Mapping / Q000662:veterinary; D017422:Sequence Analysis, DNA / Q000662:veterinary; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics*
D007328:Insulin; D007335:Insulin-Like Growth Factor II; D014446:Tyrosine 3-Monooxygenase