[Effect of bovine serum albumin on the character of autolytic changes in the lipid component of rat gray and white brain matter in vitro].
The influence of cytoprotecting concentrations of bovine serum albumin (BSA) on the autolytic alterations of rat brain white and grey matters in the physiological solution containing was investigated, In the autolysed grey matter exogenous BSA prevents the decomposition of phospholipids and the gaining the free fatty acids up to 1 hr of incubation and increased the content of cholesterol esters at the 4th and 24th hrs of autolysis BSA increased the phospholipids breakdown at the late stages of autolysis (24 hrs). On the contrary, BSA activated the phospholipids break down in the white matter already at the early periods of incubation (10 mins). It also altered the character of cholesterol and esters pendulous interactions on the opposite one, promoting the significant increase of the latters, especially at the 10th min and 4th hr of the autolysis.
Tver State University.
G A
GA
Gribanov
M Iu
MIu
Golovko
D000818:Animals; D001329:Autolysis; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D008297:Male; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D012710:Serum Albumin, Bovine / Q000494:pharmacology*
D005230:Fatty Acids, Nonesterified; D010743:Phospholipids; D012710:Serum Albumin, Bovine