Topiramate increases cerebral GABA in healthy humans.
Topiramate (TOP) is a novel anticonvulsant drug with multiple mechanisms of action used in the treatment of epilepsy. Measurements of cerebral GABA were obtained in six controls using 1H MRS at baseline and at 3 and 6 hours following the administration of 3 mg/kg of TOP. Brain GABA concentrations rose by 72% at 3 hours and by 64% at 6 hours compared with baseline (p < 0.004). This study demonstrates that TOP significantly increases human cerebral GABA concentrations in healthy individuals.
UAB Epilepsy Center, Department of Neurology, University of Alabama, Birmingham, USA.
R
R
Kuzniecky
H
H
Hetherington
S
S
Ho
J
J
Pan
R
R
Martin
F
F
Gilliam
J
J
Hugg
E
E
Faught
D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D005632:Fructose / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D012016:Reference Values; D000077236:Topiramate; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose; D005680:gamma-Aminobutyric Acid