Genomic organization of the human alpha 3 integrin subunit gene.
The alpha 3 beta 1 integrin is a receptor for various laminin isoforms and plays an important role in the maintenance of tissue integrity. We have characterized the genomic structure of the complete gene for the human alpha 3 integrin subunit. The gene contains 26 exons spanning a region of 36.3 kb of genomic DNA. Its structure closely resembles that of alpha 6, another of the three integrin alpha-subunits that are part of laminin receptors, except that it lacks the corresponding exon 5A, which encodes an X1 region in the extracellular domain of alpha 6. However, the alpha 3 gene contains the equivalent of an exon 5B for an X2-like region, which in alpha 6 and alpha 7 is present only in certain tissue-specific alternative transcripts. The two A and B cytoplasmic variants of alpha 3, which are common to the three laminin receptor integrin alpha-subunits, are encoded by separate exons.
Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
S D
SD
Jones
A
A
van der Flier
A
A
Sonnenberg
D017398:Alternative Splicing; D015703:Antigens, CD / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics*; D001483:Base Sequence; D002886:Chromosomes, Human, Pair 17; D003001:Cloning, Molecular; D019143:Evolution, Molecular; D005091:Exons; D014644:Genetic Variation; D006801:Humans; D039422:Integrin alpha3; D016023:Integrins / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics*; D007438:Introns; D008969:Molecular Sequence Data
D015703:Antigens, CD; D039422:Integrin alpha3; D016023:Integrins