Association of inhaled corticosteroid use with cataract extraction in elderly patients.
BACKGROUND
The use of systemic corticosteroids is a known risk factor for the development of cataracts.


OBJECTIVE
To determine whether treatment with inhaled corticosteroids is associated with cataract extraction in the elderly.


METHODS
Case-control study.


METHODS
Quebec universal health insurance program for all elderly (provincial health insurance plan database [RAMQ database]).


METHODS
RAMQ enrollees 70 years and older. The 3677 cases were patients with a cataract extraction between 1992 and 1994. The 21868 controls were randomly selected from patients who did not have a diagnosis of cataract and matched to cases on the index date of the case.


METHODS
Odds ratio of cataract extraction in patients with prolonged cumulative exposure to inhaled corticosteroids compared with nonusers.


RESULTS
Excluding patients with systemic steroid treatment and after adjusting for age, sex, diabetes, systemic hypertension, glaucoma, ophthalmic steroids, and the number of physician claims for services, use of inhaled corticosteroids for more than 3 years was associated with undergoing cataract extraction (odds ratio [OR], 3.06; 95% confidence interval [CI], 1.53-6.13). For high average daily doses of beclomethasone or budesonide (>1 mg), the OR was elevated after more than 2 years of treatment (OR, 3.40; 95% CI, 1.49-7.76), whereas for low to medium doses (< or =1 mg) of these drugs, the OR was 1.63 (95% CI, 0.85-3.13) after 2 years.


CONCLUSIONS
Prolonged administration of high doses of inhaled corticosteroids increases the likelihood of undergoing cataract extraction in elderly patients. Further studies are needed to investigate the risk of developing cataracts for low to medium doses over longer periods.
Garbe
E
E
Potsdam Institute of Pharmacoepidemiology and Technology Assessment, Germany. 106700.3205@compuserve.com
Suissa
S
S
LeLorier
J
J
D000280:Administration, Inhalation; D000368:Aged; D000369:Aged, 80 and over; D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D016022:Case-Control Studies; D002387:Cataract Extraction / Q000706:statistics & numerical data*; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D016017:Odds Ratio; D013256:Steroids
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D013256:Steroids