Familial schizophrenia with pericentric inversion of chromosome 9: a case report.
We report a case with schizophrenia who had a pericentric inversion of chromosome 9 (inv. 9) and whose mother has the same illness and karyotype. Although inv. 9 has been considered to be a common chromosomal rearrangement without specific phenotype, recent evidence has shown that there are several different forms of inv. 9 with differential breakpoints. This indicates that phenotypes of inv. 9 may vary depending on the location of breakpoints. Thus our cases may be valuable material to localize breakpoints on chromosome 9, which may lead to cloning of a susceptibility gene for schizophrenia.
Lee
K B
KB
Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan. klee@med.teikyo-u.ac.jp
Kunugi
H
H
Nanko
S
S
D000328:Adult; D007446:Chromosome Inversion; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D006801:Humans; D008297:Male; D010641:Phenotype; D012559:Schizophrenia / Q000235:genetics*