Influence of Escherichia coli endotoxin induced fever on the pharmacokinetics and dosage regimen of oxytetracycline in cross-bred calves.
The pharmacokinetics and dosage regimen of oxytetracycline were determined in healthy and febrile cross-bred calves following its single intravenous administration (10 mg kg-1). Fever was induced by a single intravenous injection of E. coli endotoxin (1 microgram kg-1 i.v.). The elimination half-life (t1/2 beta) and the apparent volume of distribution [vd(area)] were slightly increased in febrile calves, as compared to healthy animals. The values of t1/2 beta and Vd(area) were 3.22 +/- 0.20 h and 0.49 +/- 0.02 L. kg-1 in healthy calves and 4.06 +/- 0.32 h and 0.70 +/- 0.09 L kg-1, respectively, in febrile calves. An intravenous dosage regimen suitable for maintaining the minimum therapeutic plasma concentration of > or = 2 micrograms/ml in febrile animals would be 10 mg kg-1 repeated at 12-h intervals.
Department of Veterinary Medicine, College of Veterinary Science, Punjab Agricultural University, Ludhiana, India.
R P
RP
Singh
A K
AK
Srivastava
S K
SK
Sharma
D C
DC
Nauriyal
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D002417:Cattle; D002418:Cattle Diseases / Q000378:metabolism*; D004731:Endotoxins / Q000494:pharmacology*; D004926:Escherichia coli / Q000737:chemistry*; D005334:Fever / Q000378:metabolism / Q000382:microbiology / Q000662:veterinary*; D006207:Half-Life; D007275:Injections, Intravenous / Q000662:veterinary; D008070:Lipopolysaccharides / Q000494:pharmacology*; D010118:Oxytetracycline / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D000900:Anti-Bacterial Agents; D004731:Endotoxins; D008070:Lipopolysaccharides; C044101:endotoxin, Escherichia coli; D010118:Oxytetracycline