Cell death and survival during ovarian follicle development.
Mammalian germ cells arise in the yolk sac endoderm at the caudal aspect of the embryo and migrate to the mesodermally-derived gonadal ridge early in development. After the oogonia reach the gonadal ridge, the process of meiosis begins which coincides with the first major wave of apoptosis of female germ cells (Coucouvanis et al., 1993). Subsequently, oocytes progress to the dictyate stage of prophase I where they remain arrested until ovulation.
McGee
E A
EA
Department of Gynecology and Obstetrics, Stanford University Medical Center, CA 94305, USA.
Hsu
S Y
SY
Kaipia
A
A
Hsueh
A J
AJ
D000818:Animals; D017209:Apoptosis; D002352:Carrier Proteins / Q000378:metabolism; D002470:Cell Survival; D005260:Female; D006080:Ovarian Follicle / Q000166:cytology / Q000254:growth & development*; D010053:Ovary / Q000166:cytology / Q000254:growth & development*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D051381:Rats; D051025:bcl-Associated Death Protein
C494821:Bad protein, rat; D002352:Carrier Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D051025:bcl-Associated Death Protein