[Probable prognostic markers of immune status in patients with chronic infectious diseases].
The comparative study of the main characteristics of immune status in patients with urogenital chlamydiosis, furunculosis, urogenital herpes (38 patients) and in the members of the control group (21 subjects) was made. The analysis of the results obtained in this study revealed the numerical values of immunological characteristics, capable of being used as markers indicating transition into the chronic form. Thus, it showed a decrease in the population of cells with phenotype CD72+ in chlamydiosis; a fourfold increase in the population of cells with phenotype CD16+ in furunculosis; an increase in the population of cells with phenotype CD8+, a decrease in the immunoregulatory index and the population of cells with phenotype CD72+ in herpes. The data thus obtained may be used in prescribing immunocorrective therapy.
Research Institute of Physico-Chemical Medicine, Moscow, Russia.
E V
EV
Kovalenko
S A
SA
Novitskaia
D015703:Antigens, CD / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002690:Chlamydia Infections / Q000276:immunology; D002908:Chronic Disease; D052776:Female Urogenital Diseases / Q000276:immunology*; D005667:Furunculosis / Q000276:immunology*; D006558:Herpes Genitalis / Q000276:immunology; D006801:Humans; D007109:Immunity / Q000502:physiology*; D052801:Male Urogenital Diseases; D010641:Phenotype; D011336:Probability; D011379:Prognosis
D015703:Antigens, CD; D015415:Biomarkers