Sudden cardiac death: a matter of faulty ion channels?
Recent evidence suggests that various forms of sudden cardiac death in people with hearts that apparently function normally are caused by inherited or de novo mutations in genes coding for ion channel subunits.
Jongsma
H J
HJ
Department of Medical Physiology and Sports Medicine Utrecht University PO Box 80043, 3508 TA, Utrecht, The Netherlands.
D000595:Amino Acid Sequence; D016757:Death, Sudden, Cardiac; D006321:Heart / Q000502:physiology / Q000503:physiopathology; D006801:Humans; D007473:Ion Channels / Q000235:genetics* / Q000502:physiology; D008955:Models, Cardiovascular; D008969:Molecular Sequence Data; D009154:Mutation; D062554:NAV1.5 Voltage-Gated Sodium Channel; D017433:Protein Structure, Secondary; D015222:Sodium Channels / Q000737:chemistry / Q000235:genetics
D007473:Ion Channels; D062554:NAV1.5 Voltage-Gated Sodium Channel; C568320:SCN5A protein, human; D015222:Sodium Channels