[The usefulness of the desensitization to rifampin in the treatment of mycobacterial disease in patients with AIDS].
BACKGROUND
Hypersensitivity reactions to rifampin are relatively uncommon, but they may result in cessation of therapeutic medications.


METHODS
We report our experience with oral desensitization protocol to rifampin in a group of 35 HIV-positive patients with mycobacterial disease who had some hypersensitivity reaction to this drug.


RESULTS
Adverse reactions with this protocol were few and easily treated.


CONCLUSIONS
Oral desensitization to rifampin is safe and effective, allowing some of these patients (60%) to reintroduce the drug and to reduce the time of treatment.
Unidad de Enfermedades Infecciosas, Hospital Nuestra Señora de Aránzazu, San Sebastián. jerriz@conecta.es
J
J
Arrizabalaga
A
A
Casas
X
X
Camino
J A
JA
Iribarren
F
F
Rodríguez Arrondo
M A
MA
Von Wichmann
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D000328:Adult; D000904:Antibiotics, Antitubercular / Q000009:adverse effects / Q000276:immunology*; D003888:Desensitization, Immunologic; D004342:Drug Hypersensitivity / Q000209:etiology / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D012293:Rifampin / Q000009:adverse effects / Q000276:immunology*; D014376:Tuberculosis / Q000150:complications / Q000188:drug therapy*
D000904:Antibiotics, Antitubercular; D012293:Rifampin