[Method of preventing hepatic artery occlusion during continuous intrahepatic arterial infusion chemotherapy of 5-FU].
A randomized clinical trial of combined use of steroids, which have a vascular endothelium-protecting action, was performed to develop a method to prevent hepatic artery occlusion during continuous intrahepatic arterial infusion chemotherapy with 5-FU. The steroid used was dexamethasone palmitate (Limethason), which has a high rate of uptake by endothelial cells. The 24 patients with advanced colorectal cancer were divided into 2 groups randomly and both were treated with 5-FU 250 mg/day by continuous hepatic arterial infusion for three weeks. The weekly dose was 5-FU 7 V (1,750 mg) adjusted to 50 ml with physiological saline in Group A and 5-FU 7 V (1,750 mg) adjusted to 50 ml with Limethason 1 A (4.0 mg of dexamethasone palmitate) in Group B. The reservoir was replaced every week. No changes in the mixture (appearance, pH, granule diameter, dexamethasone palmitate content) were observed up to one week. Hepatic arterial stenosis was observed in 8 cases in Group A (67%), but was not observed in any of the cases in Group B. The above results indicated that Limethason has a preventive effect against hepatic artery occlusion.
Sadahiro
S
S
Dept. of Surgery, Tokai University.
Mukai
M
M
Tokunaga
N
N
Ishida
H
H
Suzuki
T
T
Ishikawa
K
K
Iwase
H
H
Kameya
T
T
Itoh
I
I
Yasuda
S
S
Tajima
T
T
Makuuchi
H
H
Ohtaki
M
M
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D001157:Arterial Occlusive Diseases / Q000517:prevention & control*; D015179:Colorectal Neoplasms / Q000473:pathology; D003907:Dexamethasone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005472:Fluorouracil / Q000008:administration & dosage*; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary
D000893:Anti-Inflammatory Agents; D000964:Antimetabolites, Antineoplastic; C035081:dexamethasone 21-palmitate; D003907:Dexamethasone; D005472:Fluorouracil