Update on endothelin.
Endothelin is a very potent vasoconstrictor peptide produced by the vascular endothelium. Several studies have shown that the endothelin system is activated in various cardiovascular conditions, including myocardial infarction, heart failure and pulmonary hypertension. The known actions of the endothelin-1 isoform suggest that it may be an important mediator in several of the pathophysiological manifestations of heart failure. Data on the potential value of endothelin antagonists in heart failure are reviewed.
Stewart
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University of Toronto, St Michael's Hospital, Ontario.
D019332:Endothelin-1 / Q000378:metabolism*; D016232:Endothelins / Q000096:biosynthesis*; D004730:Endothelium, Vascular / Q000378:metabolism*; D006333:Heart Failure / Q000378:metabolism; D006801:Humans; D006976:Hypertension, Pulmonary / Q000378:metabolism; D009203:Myocardial Infarction / Q000378:metabolism
D019332:Endothelin-1; D016232:Endothelins