Listeria monocytogenes as a probe to study cell-mediated immunity.
The intracellular bacterium Listeria monocytogenes continues to serve as a model to define general paradigms of cell-mediated immunity. Genetic manipulations of the bacterium and its murine host have allowed us to begin dissecting the intricate interactions between this bacterium and the immune system. As a result, we have gained new insights into the mechanisms of immune surveillance, achieved better understanding of bacterial tactics for immune evasion and developed novel strategies in vaccine development.
Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia 19104-6076, USA. hshen@mail.med.upenn.edu
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D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D017209:Apoptosis; D007111:Immunity, Cellular / Q000276:immunology*; D008089:Listeria monocytogenes / Q000276:immunology*