Differential expression of matrix metalloproteinases and their physiological inhibitors in acute murine skin wounds.
Metalloproteinase-mediated proteolysis plays an important role during all stages of wound repair. In acute murine wounds, murine collagenase, matrix metalloproteinase (MMP)-9, stromelysin-1, stromelysin-2 and tissue inhibitor of metalloproteinase (TIMP)-1 are strongly induced within 24 h after wounding. At the time of reepithelialization the expression of these gene transcripts has declined more or less completely. Each gene shows a unique spatial and temporal transcription pattern.
Max Planck Institute for Biochemistry, Martinsried, Germany. madlener@alf.biochem.mpg.de
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D000818:Animals; D017364:Collagenases / Q000378:metabolism; D053506:Matrix Metalloproteinase 10; D019278:Matrix Metalloproteinase 3 / Q000378:metabolism; D020780:Matrix Metalloproteinase 9; D008666:Metalloendopeptidases / Q000378:metabolism*; D012867:Skin / Q000293:injuries* / Q000378:metabolism; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000378:metabolism*; D014945:Wound Healing; D014947:Wounds and Injuries / Q000378:metabolism*
D019715:Tissue Inhibitor of Metalloproteinase-1; D017364:Collagenases; D008666:Metalloendopeptidases; D019278:Matrix Metalloproteinase 3; D053506:Matrix Metalloproteinase 10; D020780:Matrix Metalloproteinase 9