Lymphoma associated bone marrow necrosis with raised anticardiolipin antibody.
A case of high grade B cell lymphoma presented with bone marrow necrosis, followed by development of extensive marrow fibrosis, the evolution of which was documented by serial magnetic resonance imaging and bone marrow trephine histology. A markedly raised anticardiolipin antibody titre at diagnosis suggests that lymphoma associated antiphospholipid syndrome may have contributed to the aetiology of the bone marrow necrosis.
Murphy
P T
PT
Department of Haematology, Leicester Royal Infirmary, UK.
Sivakumaran
M
M
Casey
M C
MC
Liddicoat
A
A
Wood
J K
JK
D000368:Aged; D016736:Antiphospholipid Syndrome / Q000209:etiology*; D001853:Bone Marrow / Q000473:pathology*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000150:complications*; D008228:Lymphoma, Non-Hodgkin / Q000150:complications*; D008279:Magnetic Resonance Imaging; D008297:Male; D009336:Necrosis; D010257:Paraneoplastic Syndromes / Q000209:etiology*