Nef--an adaptor adaptor?
The Nef protein of human immunodeficiency virus (HIV) is a crucial factor in viral pathogenesis. One of the roles of this multifunctional protein is to decrease the cell-surface expression of CD4, a component of the virus receptor complex, and of MHC class I molecules. New results indicate that Nef can link CD4 to endocytic clathrin adaptor complexes and might also modulate other steps in the endocytic pathway.
Research Council, Laboratory for Molecular Cell Biology, University College, London, UK.
J
J
Oldridge
M
M
Marsh
D000818:Animals; D015704:CD4 Antigens / Q000378:metabolism; D004705:Endocytosis; D015693:Gene Products, nef / Q000378:metabolism / Q000502:physiology*; D015395:Histocompatibility Antigens Class I / Q000378:metabolism; D006801:Humans
D015704:CD4 Antigens; D015693:Gene Products, nef; D015395:Histocompatibility Antigens Class I