A sole del(15q) anomaly in post-myelodysplasia acute myeloid leukemia.
We report the second case of post-myelodysplasia acute myeloid leukemia (post-MDS AML) with a sole chromosome change del(15q). This anomaly is rarely seen. To our knowledge, only seven cases so far have been reported in human neoplasias, including one case each of acute myeloid leukemia (AML), acute lymphoid leukemia, post myelodysplasia AML, myelodysplastic syndrome, myelofibrosis, macroglobulinemia, Hodgkin's lymphoma and uterine leiomyoma. This case suggests that del(15q) is related to lympho-myeloproliferative disorders. Moreover, we speculate that certain oncogene(s) located on 15q might have some role in the progression of the disease, since the del(15q) anomaly appeared only in the AML phase in this case.
First Department of Internal Medicine, Tokyo Medical College, Japan.
N
N
Yahata
K
K
Ohyashiki
O
O
Iwase
Y
Y
Kimura
A
A
Kodama
K
K
Fukutake
K
K
Toyama
D000208:Acute Disease; D002872:Chromosome Deletion; D002884:Chromosomes, Human, Pair 15; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics*; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000150:complications