[Immunohistochemical changes in apoptosis in glioblastoma of the cerebral hemispheres].
Apoptosis was studied in 80 glioblastomas by ISEL method. Considerable variability of apoptosis index was found in glioblastomas, this indicating a non-uniform role of the "programmed death" in these malignant tumors. A certain association is established between the apoptosis expression and expression of p53 oncoprotein. The highest and more stable apoptosis indices were in glioblastomas with p53 labeling index from 11 to 35%.
N. N. Burdenko Research Institute of Neurosurgery, Moscow.
A G
AG
Korshunov
R V
RV
Sycheva
A V
AV
Golanov
D000328:Adult; D000368:Aged; D017209:Apoptosis / Q000502:physiology*; D001932:Brain Neoplasms / Q000737:chemistry* / Q000473:pathology; D002455:Cell Division / Q000502:physiology; D005260:Female; D005909:Glioblastoma / Q000737:chemistry* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis
D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53