Dissociation between genes activated in long-term potentiation and in spatial learning in the rat.
We have compared changes in mRNA of three genes, zif268, raf B, and syntaxin 1 B, following the unilateral induction of long-term potentiation (LTP) in rats previously trained in a water maze, and in behaviourally naive animals. mRNA of all three genes was enhanced in the potentiated dentate gyrus of naive animals 3 h after the induction of LTP. Training did not affect expression of mRNA for zif268 or for syntaxin 1 B. Expression of raf B was enhanced by training, and in trained animals the LTP-associated increase in expression of raf B was occluded. These results suggest that LTP and spatial training engage a common pathway utilizing an increase in mRNA for raf B, and demonstrate a dissociation between LTP and spatial learning with respect to expression of zif268 and syntaxin 1B.
Richter-Levin
G
G
Division of Neurophysiology, National Institute for Medical Research, London, UK. gal.r-l@psy.haifa.ac.il
Thomas
K L
KL
Hunt
S P
SP
Bliss
T V
TV
D000818:Animals; D000954:Antigens, Surface / Q000235:genetics; D001921:Brain / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000235:genetics; D051766:Early Growth Response Protein 1; D007839:Functional Laterality; D005786:Gene Expression Regulation; D017874:Immediate-Early Proteins; D017774:Long-Term Potentiation / Q000502:physiology*; D018782:Maze Learning / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000235:genetics; D019908:Proto-Oncogene Proteins c-raf / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D013028:Space Perception; D050827:Syntaxin 1; D014157:Transcription Factors / Q000235:genetics; D014158:Transcription, Genetic; D016335:Zinc Fingers
D000954:Antigens, Surface; D004268:DNA-Binding Proteins; D051766:Early Growth Response Protein 1; C486110:Egr1 protein, rat; D017874:Immediate-Early Proteins; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; C494213:Stx1a protein, rat; D050827:Syntaxin 1; D014157:Transcription Factors; D019908:Proto-Oncogene Proteins c-raf