HLA supertypes and supermotifs: a functional perspective on HLA polymorphism.
A large fraction of HLA class I, and possibly class II, molecules can be classified into relatively few supertypes, characterized by overlapping peptide-binding repertoires and consensus B- and F-pocket structures. Cross-binding peptides are frequently recognized by specific T cells in the course of natural disease processes and in the context of multiple HLA molecules, validating the concept of HLA supertypes at the functional level.
Epimmune Incorporated, San Diego, CA 92121, USA. asette@epimmune.com
A
A
Sette
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Sidney
D000818:Animals; D003141:Communicable Diseases / Q000276:immunology; D019143:Evolution, Molecular; D006680:HLA Antigens / Q000276:immunology*; D015789:HLA-A2 Antigen / Q000276:immunology; D015791:HLA-A3 Antigen / Q000276:immunology; D006801:Humans; D009369:Neoplasms / Q000276:immunology; D011110:Polymorphism, Genetic
D006680:HLA Antigens; D015789:HLA-A2 Antigen; D015791:HLA-A3 Antigen