Linear epidermolytic epidermal naevus--a case report.
A 25-year-old man presents with linear verrucous epidermal naevus since birth. A biopsy done showed histological features of epidermolytic hyperkeratosis. Patients with epidermolytic epidermal naevi can give rise to children with a rare but serious condition known as congenital bullous icthyosiform erythroderma. Recently, keratin mutations have been described in both conditions and the relationship between the two can be explained using the concept of genetic mosaicism.
National Skin Centre, Singapore.
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D000328:Adult; D006801:Humans; D016113:Ichthyosiform Erythroderma, Congenital / Q000235:genetics; D008297:Male; D009030:Mosaicism; D009506:Nevus / Q000235:genetics; D012868:Skin Abnormalities / Q000235:genetics*