Usefulness of tacrolimus versus cyclosporine after pediatric heart transplantation.
This study compared the early clinical course of 9 pediatric heart transplantation recipients treated with cyclosporine A-based immunosuppression with 10 similarly aged recipients treated with tacrolimus-based therapy. One-year follow-up after transplantation revealed that tacrolimus-treated children had similar left ventricular function, experienced fewer episodes of severe rejection, were more rapidly weaned from corticosteroids, and had relatively few side effects from immunosuppression compared with cyclosporine A-treated children.
Herzberg
G Z
GZ
Department of Pediatrics, The Mount Sinai School of Medicine, New York, New York, USA.
Rossi
A F
AF
Courtney
M
M
Lansman
S L
SL
Gelb
B D
BD
Parness
I A
IA
Lai
W W
WW
D000293:Adolescent; D002648:Child; D016572:Cyclosporine / Q000627:therapeutic use*; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D016027:Heart Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D016559:Tacrolimus / Q000627:therapeutic use*; D016896:Treatment Outcome
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D016559:Tacrolimus