Umbilical cord blood transplant from HLA-mismatched unrelated donor in high-risk leukemia.
Twelve consecutive children with high-risk leukemia have been submitted to UCB transplant from unrelated 1 or 2 loci HLA-mismatched donor. All patients received an identical regimen for conditioning and GVHD prophylaxis. The median dose of viable nucleated cells infused was 2.8 x 10(7)/kg bw (range 1.4-7.9). Of 11 patients evaluable for engraftment, the hematopoiesis was of full donor origin in seven patients and autologous in four. The probability of disease-free survival at 1 and 2 years from UCB transplant is 60 and 42%, respectively.
Dipartimento di Biotecnologie Cellulari ed Ematologia, University La Sapienza, Rome, Italy.
W
W
Arcese
A P
AP
Iori
M
M
Screnci
C
C
Guglielmi
A
A
Mengarelli
D
D
Carmini
A M
AM
Testi
M L
ML
Moleti
G
G
Cimino
P
P
Perrone
L
L
Laurenti
L
L
Elia
F
F
Boecklin
A
A
Romano
L
L
De Felice
F
F
Mandelli
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D005312:Fetal Blood; D016332:Fetal Tissue Transplantation; D018380:Hematopoietic Stem Cell Transplantation; D006650:Histocompatibility Testing; D006801:Humans; D007938:Leukemia / Q000628:therapy*; D008297:Male; D014184:Transplantation, Homologous; D016896:Treatment Outcome