Modeling the normal and neoplastic cell cycle with "realistic Boolean genetic networks": their application for understanding carcinogenesis and assessing therapeutic strategies.
In this paper we show how Boolean genetic networks could be used to address complex problems in cancer biology. First, we describe a general strategy to generate Boolean genetic networks that incorporate all relevant biochemical and physiological parameters and cover all of their regulatory interactions in a deterministic manner. Second, we introduce "realistic Boolean genetic networks" that produce time series measurements very similar to those detected in actual biological systems. Third, we outline a series of essential questions related to cancer biology and cancer therapy that could be addressed by the use of "realistic Boolean genetic network" modeling.
Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. zszallas@mx3.usuhs.mil
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D002453:Cell Cycle / Q000235:genetics*; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D003198:Computer Simulation; D006801:Humans; D008128:Logic; D008957:Models, Genetic; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology / Q000517:prevention & control / Q000628:therapy; D009415:Nerve Net; D011336:Probability