Effect of sulphur mustard inhalation exposure on some urinary variables in mice.
The effect of sulphur mustard (2,2'-dichlorodiethyl sulphide) exposure through inhalation at 0.5. 1.0 and 2.0 LC50 (21.2, 42.3 and 84.6 mg m(-3) for 1 h) on some urinary variables was studied in female mice at 6, 24 and 48 h and 7 days post-exposure. The urinary excretion and circulatory blood accumulation of uric acid increased significantly. The level of creatine was also elevated significantly as compared to the control at 2 LC50. It is concluded that sulphur mustard alkylates DNA and triggers catabolism of apurinated purine bases in a very short time. The increase in uric acid excretion in urine can be detected only when the exposure concentration is high.
Kumar
O
O
Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior, India.
Vijayaraghavan
R
R
D000280:Administration, Inhalation; D000818:Animals; D002273:Carcinogens / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D002619:Chemical Warfare Agents / Q000378:metabolism / Q000633:toxicity*; D003401:Creatine / Q000652:urine; D003404:Creatinine / Q000652:urine; D005260:Female; D051379:Mice; D009151:Mustard Gas / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D011687:Purines / Q000378:metabolism; D014527:Uric Acid / Q000097:blood / Q000652:urine*
D002273:Carcinogens; D002619:Chemical Warfare Agents; D011687:Purines; D014527:Uric Acid; D003404:Creatinine; D003401:Creatine; D009151:Mustard Gas