Radiographic bone loss correlations and technetium-99m-MDP bone uptake in ligature-induced periodontal disease in the beagle.
The goal of this study was to develop an animal model for the study of acute periodontal disease using silk ligatures in combination with a soft diet in eleven purebred beagle dogs. The silk ligatures were placed subgingivally on the mandible second and fourth premolar on one side of the mouth; the opposite side served as a control. Dogs were monitored during the 16-20 weeks of ligature placement, and for 48 weeks after ligature removal. Development of periodontal disease was evaluated by radiopharmaceutical uptake into bone, radiographic evidence of alveolar bone loss, attachment loss, gingival index and prostaglandin level. Bone loss occurred on the ligatured side during the ligature phase of the study. Radiopharmaceutical uptake was correlated with radiographic evidence of bone loss during the ligature phase. No significant bone loss occurred during the post-ligature phase. Progressive periodontal disease was induced during ligature placement. However, a chronic less aggressive form was not sustained by soft diet alone after ligature removal.
College of Veterinary Medicine, Mississippi State University, Mississippi State 39762-9825, USA.
M
M
Holland
J G
JG
Boring
C R
CR
Boyle
H M
HM
Pickrum
M K
MK
Jeffcoat
D000208:Acute Disease; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging*; D000539:Alveolar Process / Q000000981:diagnostic imaging; D000818:Animals; D001641:Bicuspid; D002908:Chronic Disease; D004032:Diet / Q000009:adverse effects; D004195:Disease Models, Animal; D018450:Disease Progression; D004285:Dogs; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry; D008026:Ligation / Q000295:instrumentation; D008334:Mandible / Q000000981:diagnostic imaging; D017622:Periodontal Attachment Loss / Q000000981:diagnostic imaging; D010510:Periodontal Diseases / Q000000981:diagnostic imaging*; D010512:Periodontal Index; D011453:Prostaglandins / Q000032:analysis; D011859:Radiography; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013669:Technetium Tc 99m Medronate
D011453:Prostaglandins; D019275:Radiopharmaceuticals; D013669:Technetium Tc 99m Medronate