Cytogenetic analysis and fluorescence in situ hybridization in a case of IgD multiple myeloma.
Immunoglobulin D multiple myeloma (IgD MM) is a subentity of MM occurring in fewer than 2% of patients with distinct clinical pattern, dismal prognosis, and very little information about genetic abnormalities. The karyotype and the results of fluorescent interphase in situ hybridization analysis of a 62-year-old female patient with IgD MM are presented and show a complex hypodiploid karyotype with loss of an X chromosome and monosomy 13--very well known adverse prognostic factors in MM--but, in addition, several deletions of chromosomes 1, 6, 11, and 12, as well as translocations involving chromosomes 4, 9, 10, 15, 16, and 21 that underline the singularity of IgD MM.
Weinländer
G
G
Department of Internal Medicine I, University of Vienna, Austria.
Drach
J
J
Raderer
M
M
Okamoto
I
I
Ackermann
J
J
Stögermayer
B
B
Fazeny
B
B
Nowotny
H
H
Marosi
C
C
D000368:Aged; D002880:Chromosomes, Human, Pair 11; D002893:Chromosomes, Human, Pair 3; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006801:Humans; D007072:Immunoglobulin D / Q000235:genetics*; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D009101:Multiple Myeloma / Q000235:genetics* / Q000473:pathology* / Q000628:therapy
D007072:Immunoglobulin D