Nef--an adaptor adaptor?
The Nef protein of human immunodeficiency virus (HIV) is a crucial factor in viral pathogenesis. One of the roles of this multifunctional protein is to decrease the cell-surface expression of CD4, a component of the virus receptor complex, and of MHC class I molecules. New results indicate that Nef can link CD4 to endocytic clathrin adaptor complexes and might also modulate other steps in the endocytic pathway.
Oldridge
J
J
Research Council, Laboratory for Molecular Cell Biology, University College, London, UK.
Marsh
M
M
D000818:Animals; D015704:CD4 Antigens / Q000378:metabolism; D004705:Endocytosis; D015693:Gene Products, nef / Q000378:metabolism / Q000502:physiology*; D015395:Histocompatibility Antigens Class I / Q000378:metabolism; D006801:Humans
D015704:CD4 Antigens; D015693:Gene Products, nef; D015395:Histocompatibility Antigens Class I