Nitric oxide in mechanisms of brain damage induced by neurotoxic effect of glutamate.
Nitric oxide (NO) is a gaseous chemical messenger which plays the role of a universal modulator of various physiological functions of animals including the nervous system, i.e., interneuronal communications, synaptic plasticity, memory formation, receptor functions, intracellular signal transmission, release of neurotransmitters. The possible role of NO is considered in some basic diseases of the central nervous system which are associated with the neurotoxic effect of glutamate (ischemia, stroke, convulsive disorders, etc.). NO is believed to be a key pathophysiological factor of these diseases. The production of NO in the brain cortex of rats was found to significantly increase during convulsions of various origin.
Bashkatova
V G
VG
Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, 125315, Russia.
Rayevsky
K S
KS
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D001930:Brain Injuries / Q000209:etiology* / Q000503:physiopathology*; D002545:Brain Ischemia / Q000209:etiology / Q000503:physiopathology; D004827:Epilepsy / Q000209:etiology / Q000503:physiopathology; D018698:Glutamic Acid / Q000633:toxicity*; D006801:Humans; D018377:Neurotransmitter Agents / Q000502:physiology; D009569:Nitric Oxide / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors / Q000502:physiology; D052248:Nitric Oxide Synthase Type I; D051381:Rats; D015398:Signal Transduction
D018377:Neurotransmitter Agents; D009569:Nitric Oxide; D018698:Glutamic Acid; C496320:NOS1 protein, human; D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I; C496322:Nos1 protein, rat