[Correlation of pituitary hormones in serum of male patients with fertility problems].
FSH, LH and prolactin serum levels estimations are the part of the most diagnostic procedures in andrology but there is their prediction value under discussion all the time.


OBJECTIVE
To judge the sensitivity of pituitary hormones serum levels estimation as the diagnostic method in male subfertility and to investigate the correlation between FSH, LH and PRL depending on their physiological or pathological ranges.


METHODS
FSH, LH and PRL serum levels were estimated in 36 males with azoospermia or severe oligozoospermia (density below 5 mln sperm per milliliter) by EIA. The percentage of pathologic values for every hormones was counted. The statistic analyzes (for p. < 0.05) of correlation factor between every couple of hormones were performed in full investigated group and in subgroups which were formed in following way: A-12 men with pathologic FSH serum levels, B-9 men with pathologic LH serum levels and C-24 men with both physiologic gonadotropins serum levels.


RESULTS
The percentage of FSH, LH and PRL pathologic values was in all subfertile men: 33%, 25% and 19.4% respectively. The correlation factor for FSH and LH was high in whole group (0.9484), it was the highest in both groups with FSH and LH pathologic levels (almost 1.0). In the group with physiological FSH and LH serum levels this positive correlation was significantly weak but also present (0.4107). The prolactin is completely independent without the correlation with any gonadotropins in any groups.


CONCLUSIONS
1. The sensitivity of the investigations of pituitary hormones during the diagnostic procedures of male fertility disturbances is poor. 2. Gonadotropins and prolactin infertile male serum levels are completely independent. 3. Positive correlation between FSH and LH increases in the pathological range of their values.
Kliniki Rozrodczości i Andrologii Akademii Medycznej w Lublinie.
G
G
Jakiel
S
S
Bakalczuk
M
M
Bokiniec
A
A
Mroczkowski
A
A
Jakubczak
D
D
Swatowski
D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D007248:Infertility, Male / Q000097:blood* / Q000150:complications; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D009845:Oligospermia / Q000150:complications; D011388:Prolactin / Q000097:blood*
D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone