Neuropharmacological activity of Solanum nigrum fruit.
The ethanol extract of the fruit of Solanum nigrum L. (Solanaceae) was studied for its neuropharmacological properties on experimental animals. On intraperitoneal injection, the extract significantly prolonged pentobarbital-induced sleeping time, produced alteration in the general behavior pattern, reduced exploratory behavior pattern, suppressed the aggressive behavior, affected locomotor activity and reduced spontaneous motility. The observations suggest that the fruit of S. nigrum possesses potential CNS-depressant action.
Laboratorio de Investigación de Productos Naturales, Escuela Superior de Ingenieria Química e Industrias Extractivas, Mexico DF, Mexico.
R M
RM
Perez
J A
JA
Perez
L M
LM
Garcia
H
H
Sossa
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012890:Sleep / Q000187:drug effects*; D019657:Solanaceae / Q000737:chemistry*
D000927:Anticonvulsants; D010936:Plant Extracts