Autoimmune enteropathy with severe atrophic gastritis and colitis in an adult: proposal of a generalized autoimmune disorder of the alimentary tract.
BACKGROUND
We describe the case of an adult with autoimmune enteropathy consistent with both severe atrophic gastritis accompanying antral stenosis and colitis.


RESULTS
The patient, positive for anti-intrinsic factor antibody, had intractable diarrhea and protein-losing enteropathy. In the ileum inflammatory cells were observed infiltrating the lamina propria along with villus atrophy, and similar inflammation was also found in the lamina propria of the colon and stomach, with complete loss of specialized glands. The myenteric ganglion cells of the hypertrophied muscularis propria in the stenosed antrum showed degeneration with surrounding T-lymphocyte infiltration. There were more CD8+ than CD4 lymphocytes in the lamina propria of the stomach and colon.


CONCLUSIONS
The CD8+ (suppressor-cytotoxic) T lymphocytes may have played an important role in the production of lesions in the stomach, small intestine, and colon, so we propose this case as an example of a generalized autoimmune disorder of the alimentary tract.
Mitomi
H
H
Dept. of Pathology, School of Medicine, Kitasato University, Japan.
Tanabe
S
S
Igarashi
M
M
Katsumata
T
T
Arai
N
N
Kikuchi
S
S
Kiyohashi
A
A
Okayasu
I
I
D001327:Autoimmune Diseases / Q000150:complications / Q000473:pathology*; D003092:Colitis / Q000150:complications / Q000473:pathology*; D017809:Fatal Outcome; D005757:Gastritis, Atrophic / Q000150:complications / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D011504:Protein-Losing Enteropathies / Q000150:complications / Q000473:pathology*; D012720:Severity of Illness Index; D019108:Tight Junctions / Q000648:ultrastructure