[The preservability of sibazon breakdown products in the cadavers of experimental animals].
Cibasone degradation products were measured in corpses of 15 cats poisoned with cibasone in a dose of 750 mg/kg. Cibasone was assessed by semiquantitative method on Silufol UV-254 plates from the content of the main degradation product 3-methylamino-5-chloro-benzophenone (MCB) in parallel with label in the benzene system. MCB was detectable in cadaveric material and in the container bottom panel for up to 7 years 8 months and in soft tissue until their complete putrefactive destruction. MCB concentrations were the highest in the stomach, thin intestine, and liver and the lowest in the muscles and bones. The main product of elenium (chlozepide) degradation product 2-amino-chloro-benzophenone (ACB) was detected along with MCB in a year and up to 4 years 7 months after burial, although elenium was not injected. Degradation products were identified by electron spectroscopy in UV and visible bands of the spectrum: lambda max = 238 and 410 nm for MCB and 238 and 390 nm for ACB. ACB is the product of MCB degradation-dimethylation in putrefactive degradation of tissues. Ethanol extraction of degradation products detects MCB and ACB 7 years 8 months postmortem.
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D000818:Animals; D014151:Anti-Anxiety Agents / Q000032:analysis / Q000302:isolation & purification / Q000378:metabolism* / Q000506:poisoning; D001344:Autopsy; D001577:Benzophenones / Q000032:analysis; D002048:Burial; D002415:Cats; D002707:Chlordiazepoxide / Q000032:analysis; D003975:Diazepam / Q000032:analysis / Q000302:isolation & purification / Q000378:metabolism* / Q000506:poisoning; D005260:Female; D008297:Male; D011041:Poisoning / Q000378:metabolism; D011180:Postmortem Changes; D013997:Time Factors
D014151:Anti-Anxiety Agents; D001577:Benzophenones; C082260:2-methylamino-5-chlorobenzophenone; D002707:Chlordiazepoxide; D003975:Diazepam