DNA affinity of active alkaloids from Arisarum vulgare Targ.
Some 2-alkylpyrrolidine and 2-alkylpiperidine alkaloids isolated from Arisarum vulgare Targ. demonstrated activity in a high-performance liquid chromatographic system designed to detect compounds capable of interacting with DNA. (-)-R-Bgugaine (N-H), an alkaloid prepared by synthesis, exhibited an important positive response, with total inhibition of DNA absorption at 254 nm. The concentration-dependence of these compounds was determined.
Laboratoire de Phytochimie et de Pharmacognosie, Faculté des Sciences, Université Mohamed Premier, Oujda, Morocco.
A
A
Melhaoui
H
H
Belouali
D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D002417:Cattle; D002851:Chromatography, High Pressure Liquid; D004247:DNA / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010947:Plants, Toxic / Q000737:chemistry*
D000470:Alkaloids; D004247:DNA