Aeruginosin 103-A, a thrombin inhibitor from the cyanobacterium Microcystis viridis.
Aeruginosin 103-A was isolated from the cultured freshwater cyanobacterium Microcystis viridis(NIES-103). Its structure was elucidated to be 1 on the basis of 2D NMR data. This linear peptide inhibited thrombin, with an IC50 of 9.0 microgram/mL.
Laboratory of Marine Biochemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
S
S
Kodani
K
K
Ishida
M
M
Murakami
D002851:Chromatography, High Pressure Liquid; D046931:Microcystis / Q000737:chemistry*; D009842:Oligopeptides / Q000302:isolation & purification* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013917:Thrombin / Q000037:antagonists & inhibitors*
D009842:Oligopeptides; C114804:aeruginosin 103-A; D013917:Thrombin