Subchronic oral toxicity of turmeric and ethanolic turmeric extract in female mice and rats.
Subchronic oral toxicity of turmeric and ethanolic turmeric extract was studied in female Swiss mice and Wistar rats fed turmeric (0, 1 and 5%) and ethanolic turmeric extract (0, 0.05 and 0.25%) through diet for 14 and/or 90 days. The administration of a high dose of turmeric (5%) for longer duration (90 days) showed a significant reduction in body weight gain, alterations in absolute and/or relative liver weights, and hepatotoxicity i.e. focal necrosis or focal necrosis with regeneration both in mice and rats. In mice lower doses of turmeric i.e 0.2 or 1% for 14 days also showed hepatotoxicity and they were found to be more vulnerable to turmeric-induced hepatotoxicity than rats.
Carcinogenesis Division, Cancer Research Institute, Tata Memorial Centre, Parel, Mumbai, India.
S S
SS
Deshpande
V S
VS
Lalitha
A D
AD
Ingle
A S
AS
Raste
S G
SG
Gadre
G B
GB
Maru
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology; D004247:DNA / Q000096:biosynthesis; D005260:Female; D008099:Liver / Q000378:metabolism / Q000473:pathology; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity; D017365:Spices / Q000009:adverse effects*
D001798:Blood Proteins; D010936:Plant Extracts; D004247:DNA