HLA-peptide tetrameric complexes.
HLA-peptide tetrameric complexes allow the direct ex vivo visualisation of antigen-specific CD8+ T cells and natural killer cells by flow cytometry. Quantitation, phenotypic analysis and isolation of tetramer-binding cells has considerably extended our understanding of cytotoxic T lymphocyte and natural killer cell function.
Institute of Molecular Medicine, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, UK. gogg@worf.molbiol.ox.ac.uk
G S
GS
Ogg
A J
AJ
McMichael
D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D010455:Peptides / Q000276:immunology*
D006680:HLA Antigens; D010455:Peptides