G alpha q cDNA sequence from human platelets.
G-proteins play a major role in cell signaling and specific abnormalities in these proteins have been implicated in some diseases. Although, two human G alpha q coding sequences are published, they differ at functionally important regions. We have sequenced the human G alpha q cDNA synthesized from normal platelet mRNA by reverse transcription. Our results showed that the penultimate amino acid leucine is conserved in the human G alpha q sequence which has 94.4% identity in nucleotide sequence and 99.2% homology in amino acid sequence with murine sequence.
Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA 19140, USA.
J
J
Gabbeta
N
N
Dhanasekaran
A K
AK
Rao
D000595:Amino Acid Sequence; D001792:Blood Platelets / Q000737:chemistry*; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000737:chemistry; D019204:GTP-Binding Proteins / Q000737:chemistry / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction
D018076:DNA, Complementary; D019204:GTP-Binding Proteins