[Serum levels of growth hormone and insulin-like growth factor in women with empty sella].
Serum basal fasting IGF-I, hGH, insulin, prolactin and gonadotropins as well as estradiol and SHBG levels were evaluated in: 15 women with the empty sella turcica syndrome [1A], 14 women with the empty sella and pituitary microadenoma[1B], 6 ones with normal CT scan [2A] and 20 subjects with CT signs of pituitary microadenoma [2B]. There were no differences in age of the women. Both mean body mass and body mass index were the highest in group 1A. The lowest mean serum IGF-I, LH, estradiol, SHBG and the highest insulin levels were found in group 1A. Serum IGF-I level correlated negatively with age in all but 1A group. An inverse hGH/age as well as positive hGH/IGF-I correlation found in group 2A was impaired either by presence of the empty sella or microadenoma. IGF-I/insulin correlation did not occur in all but 1A group. Normally existing reverse estradiol/age correlation became positive in group 1A and vanished in patients microadenoma. Serum IGF-I level correlated negatively with gonadotropins in patients with CT signs of microadenoma.
Katedry i Kliniki Endokrynologii i Płodności Collegium Medicum, Uniwersytetu Jagiellońskiego w Krakowie.
J A
JA
Krzysiek
T
T
Milewicz
J
J
Opiła
D000328:Adult; D004652:Empty Sella Syndrome / Q000097:blood*; D004958:Estradiol / Q000097:blood; D005260:Female; D019382:Human Growth Hormone / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D007986:Luteinizing Hormone / Q000097:blood; D008875:Middle Aged; D012738:Sex Hormone-Binding Globulin / Q000032:analysis
D007328:Insulin; D012738:Sex Hormone-Binding Globulin; D019382:Human Growth Hormone; D004958:Estradiol; D007334:Insulin-Like Growth Factor I; D007986:Luteinizing Hormone