Comparative methods for identifying functional domains in protein sequences.
This chapter reviews the different approaches that have been applied to the problem of protein motif identification. Several methods are available for finding motifs within protein families, for clustering databases to identify family relationships and for searching databases that consist of motif representations. With the rapid expansion of sequence databases, which currently appear to represent most protein families, these methods are becoming increasingly important for interpretation of molecular sequence information.
Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA.
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D000595:Amino Acid Sequence; D000818:Animals; D001709:Biotechnology; D019992:Databases as Topic; D006801:Humans; D008969:Molecular Sequence Data; D019151:Peptide Library; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
D019151:Peptide Library; D011506:Proteins