[The molecular biology diagnosis of neoplastic blood diseases].
Molecular-biological approaches was applied for detection of Philadelphia chromosome in patients with chronic myeloid and acute lymphoblastic leukemias. It includes bcr-genomic probes and polymerase chain reaction with specific bcr/abl primers. The latter is more preferable for clinic use. Different diagnostic methods are compared and leukemias etiology problems are discussed.
Teleheiev
H D
HD
Dybkov
M V
MV
Bozhko
M V
MV
Tretiak
N M
NM
Maliuta
S S
SS
D000328:Adult; D001483:Base Sequence; D002648:Child; D004247:DNA / Q000097:blood / Q000235:genetics; D017931:DNA Primers; D016044:Fusion Proteins, bcr-abl / Q000235:genetics; D016313:Genes, abl / Q000235:genetics; D005819:Genetic Markers; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis* / Q000235:genetics; D008969:Molecular Sequence Data; D010677:Philadelphia Chromosome; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000235:genetics; D012313:RNA / Q000097:blood / Q000235:genetics
D017931:DNA Primers; D005819:Genetic Markers; D012313:RNA; D004247:DNA; D016044:Fusion Proteins, bcr-abl