A unique pattern of photoreceptor degeneration in cyclin D1 mutant mice.
Cyclin D1-deficient mice have small eyes with thin retinas. We observed that there was a lower level of retinal cell proliferation and a unique pattern of photoreceptor cell death. Death was first observed in scattered clusters of cells in the retina. It then appeared to spread from these few cells to nearby photoreceptors, eventually producing extensive holes in the photoreceptor layer. These holes appeared to be filled with interneurons from the inner nuclear layer. The death mainly occurred during the second to fourth postnatal weeks. Other models of photoreceptor degeneration in rodents differ in that they occur more uniformly across the retina, with death proceeding over a longer period of time until all, or nearly all, of the photoreceptors degenerate. We also tested whether expression of a bcl-2 transgene could prevent the death and found that it could not.
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Howard Hughes Medical Institute and Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.
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Cepko
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D000818:Animals; D017209:Apoptosis / Q000235:genetics; D002452:Cell Count; D019938:Cyclin D1 / Q000235:genetics*; D019254:Genes, bcl-2; D007150:Immunohistochemistry; D007395:Interneurons / Q000473:pathology; D051379:Mice; D008811:Mice, Inbred DBA; D018345:Mice, Knockout; D008822:Mice, Transgenic; D008854:Microscopy, Electron; D008938:Mitosis; D008954:Models, Biological; D009154:Mutation; D009410:Nerve Degeneration / Q000235:genetics; D010786:Photoreceptor Cells / Q000002:abnormalities* / Q000378:metabolism / Q000473:pathology*; D012160:Retina / Q000002:abnormalities / Q000378:metabolism / Q000473:pathology; D012374:Rod Cell Outer Segment / Q000002:abnormalities / Q000378:metabolism / Q000473:pathology
D019938:Cyclin D1