Indocyanine green angiographic findings in sympathetic ophthalmia.
OBJECTIVE
To analyze indocyanine green angiography (ICGA) features in two cases of sympathetic ophthalmia using a standard angiography protocol for posterior uveitis.


METHODS
Report on two patients who suffered from penetrating ocular injuries 45 and 8 years before sympathetic ophthalmia was diagnosed and confirmed by histopathological examination of the enucleated eye. In addition to routine examination and fluorescein angiography, initial and follow-up ICGAs were performed.


RESULTS
The first patient, with a phthisic right eye following s shotgun injury, consulted 6 months after cataract extraction in his good left eye for progressive visual loss due to a neovascular membrane in a moderately inflamed eye. The second patient consulted 8 years after a perforating injury of his right eye by a metallic foreign body because of recent visual loss and inflammation in his good left eye. ICGA of both patients showed numerous hypofluorescent dark dots visible at the intermediate phase, some becoming isofluorescent at the late phase and resolving after long-term corticosteroid therapy, others remaining hypofluorescent until the late phase.


CONCLUSIONS
The two patterns of hypofluorescent areas, either persisting throughout angiography or fading in the late phase, were interpreted respectively as cicatricial and active lesions. ICGA gave determining additional information on choroidal involvement and on subsequent evolution of lesions.
Department of Ophthalmology, Hôpital Jules Gonin, University of Lausanne, Switzerland.
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Bernasconi
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Auer
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Zografos
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Herbort
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005129:Eye Foreign Bodies / Q000150:complications; D015807:Eye Injuries, Penetrating / Q000150:complications; D005451:Fluorescein Angiography; D005456:Fluorescent Dyes; D005654:Fundus Oculi; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D009879:Ophthalmia, Sympathetic / Q000175:diagnosis* / Q000209:etiology; D014792:Visual Acuity; D014948:Wounds, Gunshot / Q000150:complications
D005456:Fluorescent Dyes; D007208:Indocyanine Green