Factors controlling the glycosylation potential of the Golgi apparatus.
Most of the biosynthetic reactions that generate the oligosaccharide structures of eukaryotic cells occur in compartments of the Golgi apparatus. This article provides a brief outline of the major glycosylation pathways of the Golgi, and discusses current understanding of the many factors that can control the glycosylation potential of this organelle. Old and new approaches towards elucidating the organization of glycosylation machinery in the Golgi are also considered.
Glycobiology Program, UCSD, La Jolla, USA. avarki@ucsd.edu
A
A
Varki
D000818:Animals; D002240:Carbohydrate Sequence; D006031:Glycosylation; D006056:Golgi Apparatus / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D008958:Models, Molecular; D009844:Oligosaccharides / Q000737:chemistry / Q000378:metabolism; D011134:Polysaccharides / Q000737:chemistry / Q000378:metabolism
D009844:Oligosaccharides; D011134:Polysaccharides