Enalapril microbial biosensor.
Enalapril maleate (EMa) belongs to a new class of antihypertensive agents known as angiotensin converting enzyme (ACE) inhibitors. This paper describes the development of a microbial biosensor for EMa using induced Bacillus subitilis cells. This biosensor measures the acceleration of respiration during specific metabolic pathways of this drug. It has been applied, with good results, for determination of the active ingredient in the pharmaceutical tablet formulations.
Department of Analytical Chemistry, Faculty of Chemistry, University of Bucharest, Romania.
S
S
Fleschin
C
C
Bala
A A
AA
Bunaciu
A
A
Panait
H Y
HY
Aboul-Enein
D000959:Antihypertensive Agents / Q000032:analysis; D001412:Bacillus subtilis / Q000378:metabolism*; D015374:Biosensing Techniques; D002138:Calibration; D004656:Enalapril / Q000032:analysis*; D006863:Hydrogen-Ion Concentration; D010100:Oxygen / Q000032:analysis; D010101:Oxygen Consumption / Q000187:drug effects; D004364:Pharmaceutical Preparations; D013696:Temperature
D000959:Antihypertensive Agents; D004364:Pharmaceutical Preparations; D004656:Enalapril; D010100:Oxygen