Quantification of myocardial perfusion by MRI after coronary occlusion.
The objectives of this study were to define the relationship between the first order constant of Gd-DTPA transfer (K1) and the myocardial blood flow (MBF) at rest and to compare it with an equivalent relationship obtained for positron emission tomography (PET). In a canine model of permanent coronary occlusion (n = 4), myocardial and blood time concentration curves obtained by 13N-ammonia PET and Gd-DTPA-enhanced MRI were fitted by a one-compartment model to determine K1. A linear relationship was observed between MRI-derived K1 and MBF measured by microspheres (K1 = 0.88 x flow -0.015, R = 0.95), which compares favorably with the equivalent relationship derived from PET (K1 = 0.74 x flow +0.16, R = 0.88). The results of this preliminary study suggest that, at rest and distal to a permanently occluded coronary artery, myocardial perfusion quantification by MRI is possible and can challenge PET.
Center of Advanced Resonance Magnetic Development, Duke Medical Center, Durham, North Carolina. USA. vallee-jean-paul@diogenes.hcuge.ch
J P
JP
Vallée
H D
HD
Sostman
J R
JR
MacFall
T R
TR
DeGrado
J
J
Zhang
L
L
Sebbag
F R
FR
Cobb
T
T
Wheeler
L W
LW
Hedlund
T G
TG
Turkington
C E
CE
Spritzer
R E
RE
Coleman
D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D003287:Contrast Media; D003326:Coronary Circulation / Q000502:physiology*; D004285:Dogs; D019786:Gadolinium DTPA; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D009203:Myocardial Infarction / Q000175:diagnosis*; D009206:Myocardium / Q000473:pathology; D012039:Regional Blood Flow / Q000502:physiology; D014055:Tomography, Emission-Computed
D003287:Contrast Media; D019786:Gadolinium DTPA