Attenuation of intestinal and cardiovascular anaphylaxis by the salivary gland tripeptide FEG and its D-isomeric analog feG.
The effects of the submandibular gland peptide-T (SGP-T; Thr-Asp-Ile-Phe-Gly-Gly; TDIFEGG), its carboxy-terminal fragment (the tripeptide FEG; Phe-Glu-Gly), and the D-isomeric analog (feG) on intestinal and cardiovascular anaphylactic reactions were studied. The tripeptides, FEG and feG, when administered intravenously or orally to egg albumin-sensitized Hooded Lister or Sprague-Dawley rats 30 min prior to challenge with the antigen, totally prevented the disruption of intestinal motility and the development of anaphylaxis provoked diarrhea and inhibited anaphylactic hypotension by 66%. Submandibular gland peptides participate in the regulation of systemic inflammatory reactions, and the D-amino acid tripeptide, feG, is a potent, orally active anti-anaphylactic agent.
Department of Physiology, Faculty of Medicine, University of Calgary, Alberta, Canada. rmathiso@acs.ucalgary.ca
R
R
Mathison
P
P
Lo
G
G
Moore
B
B
Scott
J S
JS
Davison
D000707:Anaphylaxis / Q000517:prevention & control*; D000818:Animals; D002319:Cardiovascular System / Q000187:drug effects / Q000276:immunology*; D005260:Female; D007422:Intestines / Q000187:drug effects / Q000276:immunology*; D007536:Isomerism; D008297:Male; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013599:Systole / Q000187:drug effects
D009842:Oligopeptides; C108419:submandibular gland peptide T; C114891:tripeptide FEG