The absence of strand-specific repair for the DNA polymerase pol gene in Deinococcus radiodurans.
Deinococcus radiodurans is characterized by its extreme resistance to ionizing radiation. Although Mn+2 was taken up by the cells at a high speed, the absorption of Mn+2 by the cells did not affect their survival rate when irradiated by UV light. However, the Mn-induced-cell-division (Mn-CD) cells do lose their resistance to UV radiation. This can be explained by the fact that the Mn-CD cells were less efficient to remove pyrimidine dimers on damaged DNA. We also found that there is no strand-specific repair of the pol gene in this organism.
Department of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, ROC.
C S
CS
Lin
H C
HC
Wang
T Y
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Wong
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JK
Liu
D004249:DNA Damage; D004260:DNA Repair; D004269:DNA, Bacterial / Q000378:metabolism; D004259:DNA-Directed DNA Polymerase / Q000235:genetics*; D005798:Genes, Bacterial; D006095:Gram-Positive Cocci / Q000201:enzymology / Q000235:genetics* / Q000528:radiation effects; D008345:Manganese / Q000378:metabolism / Q000494:pharmacology; D011740:Pyrimidine Dimers / Q000378:metabolism; D014466:Ultraviolet Rays
D004269:DNA, Bacterial; D011740:Pyrimidine Dimers; D008345:Manganese; D004259:DNA-Directed DNA Polymerase