Scavenger receptors: diverse activities and promiscuous binding of polyanionic ligands.
Scavenger receptors are a diverse family of proteins that share a common property--the binding of modified lipoprotein--but they have recently been shown to recognise a diverse range of ligands. Understanding the molecular interaction of receptor-ligand binding should provide insight into how scavenger receptors contribute to important biological processes.
Platt
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Sir William Dunn School of Pathology, University of Oxford, UK. nick.platt@pathology.ox.ac.uk
Gordon
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D000595:Amino Acid Sequence; D000818:Animals; D018955:CD36 Antigens / Q000378:metabolism*; D004705:Endocytosis; D006801:Humans; D008024:Ligands; D008074:Lipoproteins / Q000378:metabolism; D008565:Membrane Proteins; D008969:Molecular Sequence Data; D011485:Protein Binding; D011971:Receptors, Immunologic / Q000378:metabolism*; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; D051122:Scavenger Receptors, Class B; D013329:Structure-Activity Relationship
D018955:CD36 Antigens; D008024:Ligands; D008074:Lipoproteins; D008565:Membrane Proteins; D011971:Receptors, Immunologic; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; C454739:Scarb1 protein, mouse; D051122:Scavenger Receptors, Class B