Cloning and tissue expression of two putative steroid membrane receptors.
We have cloned two human putative steroid binding membrane proteins, termed Hpr6.6 and Dg6. Hpr6.6 is the human homolog of a previously cloned porcine progesterone binding protein. Both proteins contain a putative transmembrane domain and a highly conserved stretch of 58 amino acids. Hpr6.6 mRNA is expressed predominantly in liver and kidney, whereas Dg6 mRNA is preferentially expressed in placenta. Hpr6.6 is located on the X chromosome and dg6 on chromosome 4. The two proteins are the first putative steroid membrane receptors cloned from man.
Gerdes
D
D
Institute of Clinical Pharmacology, Faculty of Clinical Medicine at Mannheim, University of Heidelberg, Germany.
Wehling
M
M
Leube
B
B
Falkenstein
E
E
D000595:Amino Acid Sequence; D001483:Base Sequence; D002460:Cell Line; D003001:Cloning, Molecular; D018076:DNA, Complementary; D006801:Humans; D008565:Membrane Proteins / Q000096:biosynthesis / Q000235:genetics*; D008969:Molecular Sequence Data; D011980:Receptors, Progesterone; D011987:Receptors, Steroid / Q000096:biosynthesis / Q000235:genetics*; D014018:Tissue Distribution
D018076:DNA, Complementary; D008565:Membrane Proteins; C115296:PGRMC1 protein, human; C115297:PGRMC2 protein, human; D011980:Receptors, Progesterone; D011987:Receptors, Steroid