Evaluation of a new bioresorbable barrier to facilitate guided bone regeneration around exposed implant threads. An experimental study in the monkey.
The aim of this study was to evaluate the effectiveness of a new bioresorbable barrier alone or in combination with BioOss for guided bone regeneration around dental implants with exposed implant threads. Five adult Macaca fascicularis monkeys were used in this investigation. After extraction of all premolars and first molars, two endosteal oral implants were installed in each quadrant and the bony defects were randomly treated with either: 1) placement of the new bioresorbable device alone (group 1); 2) placement of the new bioresorbable barrier in combination with BioOss (group 2); 3) placement of an ePTFE barrier in combination with BioOss (group 3); or (4) control (group 4). After a period of six months the animals were killed and the histological processing was performed. There was a significant difference in the amount of new bone regeneration around the implants between the four groups (i.e. groups 1, 2, 3 and 4) (P=0.0122). There was no difference, however, between group 2 and group 3. It can be concluded that the new bioresorbable barrier in combination with BioOss appears to obtain the same results in this type of bony defects as the grafting material in combination with an ePTFE barrier.
Department of Prosthodontics, Albert-Ludwigs-University, Freiburg, Germany.
M B
MB
Hürzeler
R J
RJ
Kohal
J
J
Naghshbandi
L F
LF
Mota
J
J
Conradt
D
D
Hutmacher
R G
RG
Caffesse
D000818:Animals; D001673:Biodegradation, Environmental; D001853:Bone Marrow / Q000473:pathology; D001861:Bone Regeneration; D016723:Bone Remodeling; D018786:Bone Substitutes / Q000627:therapeutic use; D003094:Collagen / Q000627:therapeutic use*; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D005069:Evaluation Studies as Topic; D005500:Follow-Up Studies; D016557:Guided Tissue Regeneration, Periodontal / Q000295:instrumentation* / Q000379:methods; D008252:Macaca fascicularis; D008297:Male; D008334:Mandible / Q000473:pathology / Q000601:surgery; D008437:Maxilla / Q000473:pathology / Q000601:surgery; D008567:Membranes, Artificial; D008903:Minerals / Q000627:therapeutic use; D016348:Osseointegration; D011138:Polytetrafluoroethylene; D011897:Random Allocation; D014945:Wound Healing
C077540:Bio-Oss; D018786:Bone Substitutes; D015921:Dental Implants; D008567:Membranes, Artificial; D008903:Minerals; D011138:Polytetrafluoroethylene; D003094:Collagen