Endometrial biopsy during hormone replacement cycle in donor oocyte recipients before in vitro fertilization-embryo transfer.
OBJECTIVE
To examine the usefulness of a trial cycle of hormone replacement therapy (HRT) and endometrial biopsy before the actual ET cycle in recipients of donated oocytes.


METHODS
Retrospective review.


METHODS
Clinical practice at the South Texas Fertility Center, San Antonio, Texas.


METHODS
Thirty-six concurrent patients who underwent a trial cycle of HRT with endometrial biopsy before the ET cycle with donated oocytes fertilized in vitro.


METHODS
Patients > or =40 years of age received 100 mg of i.m. progesterone in oil daily; patients <40 years of age received 50 mg daily. Endometrial biopsies were performed during the late luteal phase of the trial cycle.


METHODS
Histologic dating of the biopsy specimens was correlated with the chronologic date of the biopsy.


RESULTS
Five of 20 patients > or =40 years of age had out-of-phase biopsies. All 16 patients <40 years of age had in-phase biopsies. All out-of-phase biopsies subsequently were corrected with higher doses of progesterone. Pregnancy rates after fresh and frozen ETs were not significantly different between the two age groups.


CONCLUSIONS
Patients > or =40 years of age are at risk of having out-of-phase endometrial biopsies while they are receiving standard HRT despite receiving higher doses of progesterone. Trial HRT cycles with endometrial biopsies are recommended.
Potter
D A
DA
Department of Obstetrics and Gynecology, The University of Texas Health Sciences Center at San Antonio, USA. dpotter@flash.net
Witz
C A
CA
Burns
W N
WN
Brzyski
R G
RG
Schenken
R S
RS
D000328:Adult; D001706:Biopsy; D004359:Drug Therapy, Combination; D004624:Embryo Transfer; D004717:Endometrium / Q000187:drug effects* / Q000473:pathology; D004958:Estradiol / Q000627:therapeutic use*; D015914:Estrogen Replacement Therapy; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D016729:Leuprolide / Q000627:therapeutic use; D009865:Oocytes; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D012307:Risk Factors; D014019:Tissue Donors
D004958:Estradiol; D016729:Leuprolide