[Antagonists of glycoprotein IIb/IIIa as new antiplatelet agents].
Blood platelets play an essential role in arterial thrombosis. Platelets activation starts from their binding to membrane receptors what results in consecutive biochemical reactions. Glycoprotein IIb/IIIa receptor of fibrinogen plays a key role in platelet aggregation. Inhibition of activity of glycoprotein IIb/IIIa-fibrinogen receptor complex could prevent thrombus formation by blood platelets. Antagonists of GPIIb/IIIa are synthetic peptides, integrelin, specific monoclonal antibodies and some nonpeptide substances.
Katedry i Zakładu Biofarmacji i Farmakodynamiki Akademii Medycznej w Gdańsku.
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D000818:Animals; D001550:Benzamidines / Q000737:chemistry / Q000494:pharmacology; D000077542:Eptifibatide; D006801:Humans; D039421:Integrin alpha2; D008562:Membrane Glycoproteins / Q000037:antagonists & inhibitors*; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology*
D001550:Benzamidines; C056564:ITGA2B protein, human; D039421:Integrin alpha2; D008562:Membrane Glycoproteins; D010455:Peptides; D010975:Platelet Aggregation Inhibitors; D000077542:Eptifibatide; C091295:xemilofiban