Comparing individual signal-averaged spectra.
It is demonstrated here that individual signal-averaged NMR spectra can be compared statistically in a rigorous fashion. This is accomplished by considering the ensemble of single acquisitions, which are summed to produce spectra. Applications of this concept include assessment of the statistical significance of apparent metabolite variations in control preparations and quantitative comparison of signals obtained during the fast response period in functional MRI.
National Institutes of Health, National Institute on Aging, Baltimore, Maryland 21224, USA. spencer@helix.nih.gov
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Spencer
D000255:Adenosine Triphosphate / Q000378:metabolism; D005583:Fourier Analysis; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation*; D018482:Muscle, Skeletal / Q000502:physiology; D010710:Phosphates / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism; D012016:Reference Values; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation*
D010710:Phosphates; D010725:Phosphocreatine; D000255:Adenosine Triphosphate