The use of Neoral in rheumatoid arthritis.
Neoral (a microemulsion-based formulation) is an immunomodulator that possesses a more predictable and improved absorption than the conventional oral formulation (Sandimmun). The increased bioavailability of Neoral could result in improved efficacy. The pharmacokinetics of cyclosporin and efficacy of cyclosporin in rheumatoid arthritis are reviewed in this article. Current guidelines for the use of Neoral in the treatment of rheumatoid arthritis patients are outlined.
Cranney
A
A
Department of Medicine, University of Ottawa, Ontario, Canada.
Tugwell
P
P
D018501:Antirheumatic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D001682:Biological Availability; D016572:Cyclosporine / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004655:Emulsions; D006801:Humans; D017410:Practice Guidelines as Topic
D018501:Antirheumatic Agents; D004655:Emulsions; D016572:Cyclosporine