11C-methionine and 18F-2-fluorodeoxyglucose positron emission tomography: a tool for diagnosis of cerebral glioma and monitoring after brachytherapy with 125I seeds.
Forty-six patients with suspected brain tumors were investigated by positron emission tomography (PET). Using 11C-methionine PET, the spatial extent of increased uptake in gliomas was larger than that of contrast enhancement on CT/MR images in 67% or the same in 33%. Ten of 46 patients treated with brachytherapy for low-grade gliomas were also investigated with 18F-2-fluorodeoxyglucose (FDG)-PET. One year after seed implantation, the glucose metabolism had not changed, but the decline of methionine uptake was significant. In conclusion, 11C-methionine PET may improve tumor delineation and, following brachytherapy, provides more information on the therapeutic effects than FDG.
Department of Stereotactic and Functional Neurosurgery, University of Cologne, Germany. j.voges@uni-koeln.de
J
J
Voges
K
K
Herholz
T
T
Hölzer
M
M
Würker
B
B
Bauer
U
U
Pietrzyk
H
H
Treuer
R
R
Schröder
V
V
Sturm
W D
WD
Heiss
D000328:Adult; D001918:Brachytherapy / Q000379:methods*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000532:radiotherapy*; D002250:Carbon Radioisotopes; D005260:Female; D019788:Fluorodeoxyglucose F18; D005910:Glioma / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000532:radiotherapy*; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D008715:Methionine / Q000378:metabolism; D008875:Middle Aged; D014055:Tomography, Emission-Computed; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D002250:Carbon Radioisotopes; D007457:Iodine Radioisotopes; D019788:Fluorodeoxyglucose F18; D008715:Methionine; D005947:Glucose