Evolution to malignancy in a recurrent meningioma: morphological and cytogenetic findings.
The original tumor and 4 relapses of a recurrent meningioma were studied. We analyzed and compared these recurrences by histopathology, PCNA labelling index (PCNA-LI), nuclear count, and cytogenetical findings. The most important changes in the evolution to aggressivity were: recurrences at progressively shorter intervals, increases in the PCNA-LI, and micronecrosis; histological changes such as sheeting and increase of the extracellular matrix and a gradual transformation to a clonally complex karyotype.
Department of Pathology, University of Valencia, Spain.
M
M
Cerdá-Nicolás
C
C
López-Ginés
J
J
Barcia-Salorio
A
A
Llombart-Bosch
D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000473:pathology*; D019457:Chromosome Breakage; D005109:Extracellular Matrix / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D008297:Male; D008577:Meningeal Neoplasms / Q000235:genetics / Q000473:pathology*; D008578:Meninges / Q000473:pathology; D008579:Meningioma / Q000235:genetics / Q000473:pathology*; D008854:Microscopy, Electron; D008875:Middle Aged; D009336:Necrosis; D009364:Neoplasm Recurrence, Local / Q000235:genetics / Q000473:pathology*; D018809:Proliferating Cell Nuclear Antigen / Q000235:genetics
D018809:Proliferating Cell Nuclear Antigen