Life-threatening hemorrhage in a patient with gastric cancer and acquired hemophilia.
We report a case of a patient with life-threatening hemorrhage caused by the presence of acquired factor VIII inhibitors after gastrectomy for signet-ring cell carcinoma of the stomach. Acquired factor VIII inhibitors should be taken into consideration as a cause of acquired bleeding tendency among patients with gastrointestinal malignancies especially when the coagulation tests are unusual.
Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Japan.
Y
Y
Harada
M
M
Iwai
M
M
Miyoshi
Y
Y
Ueda
S
S
Mitsufuji
K
K
Seiki
M
M
Harada
K
K
Kashima
D000368:Aged; D018279:Carcinoma, Signet Ring Cell / Q000097:blood / Q000150:complications* / Q000628:therapy; D003131:Combined Modality Therapy; D005169:Factor VIII / Q000032:analysis / Q000037:antagonists & inhibitors; D017809:Fatal Outcome; D005260:Female; D005743:Gastrectomy; D006471:Gastrointestinal Hemorrhage / Q000097:blood / Q000209:etiology* / Q000628:therapy; D006467:Hemophilia A / Q000097:blood / Q000209:etiology* / Q000628:therapy; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000150:complications / Q000628:therapy; D013274:Stomach Neoplasms / Q000097:blood / Q000150:complications* / Q000628:therapy
D005169:Factor VIII