Monozygotic twins discordant for single umbilical artery and congenital heart disease.
We report a case of monozygotic twins. One twin had a single umbilical artery and the other co-twin had congenital heart disease. This case and a review of the literature suggest that local environmental factors are important in the pathogenesis of these malformations although genetic factors cannot be excluded.
Nakayama
D
D
Department of Obstetrics and Gynecology, Nagasaki University, School of Medicine, Japan.
Masuzaki
H
H
Yoshimura
S
S
Moriyama
S
S
Ishimaru
T
T
D000328:Adult; D004200:Diseases in Twins / Q000235:genetics*; D004782:Environmental Health; D005260:Female; D006330:Heart Defects, Congenital / Q000235:genetics*; D006801:Humans; D014430:Twins, Monozygotic / Q000235:genetics*; D014469:Umbilical Arteries / Q000002:abnormalities*