Elevated adhesiveness/aggregation of peripheral blood leukocytes in patients with major depression.
A simple slide test was used to determine the effects of major depression (MD) and heterocyclic antidepressants on leukocyte adhesiveness/aggregation (LAA) in the peripheral blood. Eighty subjects were categorized into four equal groups: untreated-MD patients, treated-MD patients, nondepressed patients treated with antidepressants and healthy controls. Significantly higher LAA values were observed both in untreated- and treated-MD patients, 13.8+/-1.7% and 13.5+/-1.9% respectively, compared to nondepressed-treated patients and healthy controls, 5.4+/-0.9% and 6.4+/-0.7% respectively (P < 0.0001). Increased LAA was associated with the depressive episode, was not affected by antidepressants and may potentially serve as a useful laboratory state marker for MD.
Geha Psychiatric Hospital, Rabin Medical Center, Petah Tikva, Sackler Faculty of Medicine, Tel Aviv University, Israel.
Z
Z
Zemishlany
D
D
Aizenberg
C
C
Klein
I
I
Modai
M
M
Aronson
A
A
Weizman
D000328:Adult; D000928:Antidepressive Agents / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects / Q000502:physiology; D002449:Cell Aggregation / Q000187:drug effects / Q000502:physiology; D003866:Depressive Disorder / Q000097:blood*; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008875:Middle Aged
D000928:Antidepressive Agents