3 beta-p-hydroxybenzoyldehydrotumulosic acid from Poria cocos, and its anti-inflammatory effect.
The structure of a new triterpene derivative isolated from Poria cocos was determined to be 3 beta-p-hydroxybenzoyldehydrotumulosic acid by spectral and chemical methods. 3 beta-p-hydroxybenzoyldehydrotumulosic acid showed marked inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)- and arachidonic acid (AA)-induced ear inflammation in mice. The 50% inhibitory doses of 3 beta-p-hydroxybenzoyldehydrotumulosic acid were 0.27 and 1.25 mg per ear on TPA- and AA-induced inflammation, respectively.
College of Pharmacy, Nihon University, Chiba, Japan.
K
K
Yasukawa
T
T
Kaminaga
S
S
Kitanaka
T
T
Tai
Y
Y
Nunoura
S
S
Natori
M
M
Takido
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000302:isolation & purification; D016718:Arachidonic Acid; D005260:Female; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D007564:Japan; D008516:Medicine, Chinese Traditional; D051379:Mice; D008813:Mice, Inbred ICR; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal; D013755:Tetradecanoylphorbol Acetate; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000627:therapeutic use
C114453:4-hydroxybenzoyldehydrotumulosic acid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D014315:Triterpenes; D016718:Arachidonic Acid; D013755:Tetradecanoylphorbol Acetate