Notch receptor activation inhibits oligodendrocyte differentiation.
In this study, we show that oligodendrocyte differentiation is powerfully inhibited by activation of the Notch pathway. Oligodendrocytes and their precursors in the developing rat optic nerve express Notch1 receptors and, at the same time, retinal ganglion cells express Jagged1, a ligand of the Notch1 receptor, along their axons. Jagged1 expression is developmentally regulated, decreasing with a time course that parallels myelination in the optic nerve. These results suggest that the timing of oligodendrocyte differentiation and myelination is controlled by the Notch pathway and raise the question of whether localization of myelination is controlled by this pathway.
Wang
S
S
Stanford University School of Medicine, Department of Neurobiology, California 94305, USA.
Sdrulla
A D
AD
diSibio
G
G
Bush
G
G
Nofziger
D
D
Hicks
C
C
Weinmaster
G
G
Barres
B A
BA
D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development; D002135:Calcium-Binding Proteins; D002454:Cell Differentiation / Q000502:physiology; D002478:Cells, Cultured; D016922:Cellular Senescence / Q000502:physiology; D018920:Coculture Techniques; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D000072100:Jagged-1 Protein; D008024:Ligands; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology*; D009836:Oligodendroglia / Q000166:cytology*; D009900:Optic Nerve / Q000166:cytology / Q000254:growth & development / Q000378:metabolism; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D011956:Receptors, Cell Surface / Q000502:physiology*; D051880:Receptors, Notch; D012160:Retina / Q000166:cytology / Q000254:growth & development / Q000378:metabolism; D000072099:Serrate-Jagged Proteins
D002135:Calcium-Binding Proteins; D036341:Intercellular Signaling Peptides and Proteins; C000606273:JAG1 protein, human; C000606275:Jag1 protein, rat; D000072100:Jagged-1 Protein; D008024:Ligands; D008565:Membrane Proteins; D011506:Proteins; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D051880:Receptors, Notch; D000072099:Serrate-Jagged Proteins