Serum malondialdehyde in HIV-seropositive children negatively correlates with CD4+ lymphocytes count.
Human immunodeficiency virus (HIV) infection is associated with oxidative stress as it has been demonstrated in adult-seropositive individuals. We show in this study that serum malondialdehyde (MDA) concentration of HIV-infected children was significantly higher than in control children. A negative correlation (r = -0.515) was found in HIV-infected children between their CD4+ lymphocyte count, and MDA concentration but not with serum antioxidant status. The increase of MDA concentration in HIV-seropositive children confirms the involvement of oxidative stress in the pathophysiology of this infection also in childhood. Because of the importance of oxidative stress and antioxidants for HIV viral replication, the adequacy of an adjuvant therapy with antioxidants should be considered; an adequate candidate for it could be N-acetylcysteine.
Department of Physiology, School of Medicine and Dentistry, University of Valencia, Spain.
E J
EJ
Jareño
F
F
Bosch-Morell
R
R
Fernández-Delgado
J
J
Donat
F J
FJ
Romero
D015415:Biomarkers / Q000097:blood; D018791:CD4 Lymphocyte Count; D002648:Child; D002675:Child, Preschool; D005260:Female; D018023:HIV Seronegativity / Q000502:physiology; D006679:HIV Seropositivity / Q000097:blood* / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D018384:Oxidative Stress; D012016:Reference Values; D012044:Regression Analysis
D015415:Biomarkers; D008315:Malondialdehyde