Free laminin in the extracellular matrix of B-cell non Hodgkin's lymphomas.
The authors show that in the perivascular stroma of B-cell non-Hodgkin's lymphomas (B-NHL) is present a granular, speckled pattern of expression of laminin, similar to the 'free-laminin' firstly described by Lugassy et al. (1997) in human melanoma. The role of this form of laminin may be to promote the migration of tumor cells, which express a variety of binding-laminin surface proteins, whose expression is significantly increased in several human cancer models.
Ribatti
D
D
Vacca
A
A
Nico
B
B
Quondamatteo
F
F
Herken
R
R
Roncali
L
L
D005109:Extracellular Matrix / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007797:Laminin / Q000032:analysis*; D008198:Lymph Nodes / Q000473:pathology / Q000648:ultrastructure; D016393:Lymphoma, B-Cell / Q000473:pathology / Q000648:ultrastructure*; D016253:Microscopy, Immunoelectron; D017154:Stromal Cells / Q000473:pathology / Q000648:ultrastructure
D007797:Laminin