Somatostatin immunoreactivity in bone and joint tissues.
Using immunoelectron microscopy we have investigated the presence of somatostatin in normal bone and joint tissues. We observed somatostatin labeling in the myelinated nerve fibers of the periosteum, the bone marrow cells and in the mature bone matrix but only slightly in the synovial cells. Quantification of somatostatin in bone tissue by radioimmunoassay showed highest levels in bone marrow followed by periosteum and cortical bone. These findings suggest a role for somatostatin in bone and joint physiology.
Department of Orthopaedic Surgery, Research Center, Karolinska Institute, Huddinge Hospital, Sweden.
A M
AM
Elhassan
A
A
Adem
K
K
Hultenby
J U
JU
Lindgren
D000818:Animals; D001853:Bone Marrow / Q000378:metabolism / Q000648:ultrastructure; D001842:Bone and Bones / Q000378:metabolism* / Q000648:ultrastructure; D005260:Female; D007150:Immunohistochemistry; D007596:Joints / Q000378:metabolism* / Q000648:ultrastructure; D016253:Microscopy, Immunoelectron; D011863:Radioimmunoassay; D051381:Rats; D011917:Rats, Inbred Lew; D013004:Somatostatin / Q000378:metabolism*
D013004:Somatostatin