T-cell receptor peptide vaccination in the treatment of rheumatoid arthritis.
In several human T-cell-mediated autoimmune diseases and animal models of such illnesses, T-cell receptors (TCR) specific for antigens that initiate or perpetuate the disease share a limited number of variable region determinants. Vaccinations with peptides derived from over-represented TCRs are effective treatment for some of these disorders. RA is a chronic inflammatory disease in which there is prominent T-cell infiltration in the synovial lining layer. TCR V beta 3, V beta 14, and V beta 17 have been found to be over-represented among IL-2 receptor-positive T-cells from patients with RA. A phase II clinical trial in RA, using a combination of three peptides derived from V beta 3, V beta 14, and V beta 17, has yielded promising results. Larger clinical efficacy and safety studies must be performed to determine if TCR peptide vaccination will become a viable treatment alternative for patients with RA.
Bridges
S L
SL
Department of Medicine, University of Alabama, Birmingham, USA. Lou.Bridges@ccc.uab.edu
Moreland
L W
LW
D000917:Antibody Formation; D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000628:therapy*; D006801:Humans; D016233:Immunotherapy, Active; D010446:Peptide Fragments / Q000627:therapeutic use; D011948:Receptors, Antigen, T-Cell / Q000276:immunology / Q000627:therapeutic use*; D014481:United States
D010446:Peptide Fragments; D011948:Receptors, Antigen, T-Cell