Design, construction and use of a large-sample field-cycled PEDRI imager.
The design, construction and use of a large-scale field-cycled proton-electron double-resonance imaging (FC-PEDRI) imager is described. The imager is based on a whole-body sized, vertical field, 59 mT permanent magnet. Field cycling is accomplished by the field compensation method, and uses a secondary, resistive magnet with an internal diameter of 52 cm. The magnetic field can be switched from zero to 59 mT or vice versa in 40 ms. It is used with a double-resonance coil assembly (NMR/EPR) comprising a solenoidal NMR transmit/receive coil and a coaxial, external birdcage resonator for EPR irradiation. Experiments to image the distribution of an exogenous nitroxide free radical in anaesthetized rabbits are described.
Department of Biomedical Physics and Bioengineering, University of Aberdeen, Foresterhill, UK.
D J
DJ
Lurie
M A
MA
Foster
D
D
Yeung
J M
JM
Hutchison
D000818:Animals; D055592:Biophysical Phenomena; D001703:Biophysics; D003497:Cyclic N-Oxides; D004578:Electron Spin Resonance Spectroscopy / Q000295:instrumentation*; D004583:Electrons; D004867:Equipment Design; D005609:Free Radicals / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation*; D011522:Protons; D011817:Rabbits; D011846:Radio Waves; D051381:Rats; D013113:Spin Labels
D003497:Cyclic N-Oxides; D005609:Free Radicals; D011522:Protons; D013113:Spin Labels; C001803:tempol