Synaptic plasticity in the CA1 and CA3 hippocampal region of pre- and postnatally lead-exposed rats.
The effects of low level lead exposure on synaptic plasticity in hippocampal regions CA1 and CA3 were determined in adult rats in vitro. In the CA3 region the NMDA (N-methyl-D-aspartate)-independent mossy fiber-CA3 synapse potentiation was not influenced by chronic pre- and postnatal lead exposure, while in the same rats, in the CA1 region the NMDA-dependent long-term potentiation was slightly reduced as compared to controls. Paired-pulse facilitation was neither impaired in CA1 nor in CA3 region in the lead-exposed rats. These findings suggest that NMDA-dependent forms of synaptic plasticity are more susceptible to chronic low level lead exposure than NMDA-independent forms of potentiation or paired-pulse facilitation.
Department of Neurotoxicology, Medical Institute of Environmental Hygiene, Heinrich-Heine-Universität, Düsseldorf, Germany. altmannl@rz.uni-duesseldorf.de
M
M
Gutowski
L
L
Altmann
K
K
Sveinsson
H
H
Wiegand
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001921:Brain / Q000378:metabolism; D004558:Electric Stimulation; D005260:Female; D006624:Hippocampus / Q000187:drug effects*; D007854:Lead / Q000097:blood / Q000493:pharmacokinetics; D007855:Lead Poisoning / Q000473:pathology*; D017774:Long-Term Potentiation / Q000187:drug effects; D019599:Mossy Fibers, Hippocampal / Q000187:drug effects / Q000502:physiology; D016202:N-Methylaspartate / Q000502:physiology; D009473:Neuronal Plasticity / Q000187:drug effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D013569:Synapses / Q000187:drug effects*
D007854:Lead; D016202:N-Methylaspartate