Adaptive thermogenesis: turning on the heat.
Brown adipocytes play important roles in the regulation of fat storage and body temperature, by virtue of their ability to uncouple mitochondrial fuel oxidation and ATP synthesis. The discovery of a tissue-specific transcriptional coactivator provides new insights into the regulation of thermogenesis by brown adipocytes.
Lowell
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BB
Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA. blowell@bidmc.harvard.edu
D000222:Adaptation, Physiological / Q000502:physiology*; D017667:Adipocytes; D002001:Adipose Tissue, Brown / Q000166:cytology / Q000502:physiology; D000818:Animals; D001833:Body Temperature Regulation / Q000502:physiology*; D002352:Carrier Proteins / Q000235:genetics; D000242:Cyclic AMP / Q000378:metabolism; D007473:Ion Channels; D008565:Membrane Proteins / Q000235:genetics; D024101:Mitochondrial Proteins; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D014475:Uncoupling Agents; D000071256:Uncoupling Protein 1
D002352:Carrier Proteins; D007473:Ion Channels; D008565:Membrane Proteins; D024101:Mitochondrial Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D014475:Uncoupling Agents; D000071256:Uncoupling Protein 1; C111264:peroxisome-proliferator-activated receptor-gamma coactivator-1; D000242:Cyclic AMP