A role for neuropeptides in UVB-induced systemic immunosuppression.
The aim of this study was to investigate the possible role of sensory nerves in UV light-induced systemic immunomodulation. Contact hypersensitivity to the low molecular weight compound picrylchloride was used as a model for cellular immunity that can be suppressed by low (i.e. suberythemal) doses of UV light even after exposure at a distant locus (i.e. systemic immunosuppression). In sensory nerve-depleted mice, achieved by two subcutaneous injections with the neurotoxin capsaicin before the age of 4 weeks, UV light exposure failed to inhibit contact hypersensitivity responses to picrylchloride. This indicates that sensory nerves are at least partially involved in the induction of systemic immunosuppression by UV light. In order to analyze whether sensory neuropeptides, such as calcitonin gene-related peptide (CGRP) and tachykinins, are involved in UV light-induced systemic immunosuppression, mice were pretreated with selective antagonists prior to each UV light exposure. These experiments indicated that CGRP but not the tachykinins plays a crucial role in the UV light-induced systemic immunosuppression.
Laboratory for Pathology and Immunobiology, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
J
J
Garssen
T L
TL
Buckley
H
H
Van Loveren
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000276:immunology; D002211:Capsaicin / Q000633:toxicity; D003877:Dermatitis, Contact; D007108:Immune Tolerance / Q000502:physiology* / Q000528:radiation effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009475:Neurons, Afferent / Q000187:drug effects / Q000276:immunology; D009479:Neuropeptides / Q000276:immunology*; D018462:Photobiology; D014466:Ultraviolet Rays / Q000009:adverse effects*
D009479:Neuropeptides; D015740:Calcitonin Gene-Related Peptide; D002211:Capsaicin