[Dose-dependent inactivation of extracellular human immunodeficiency virus by miramistin].
The effects of a cation detergent myramistin on free infectious HIV-1 LAI strain are studied. HIV-containing culture fluid was incubated with myramistin, after which Jurkat-tat T-cells were infected with this fluid in various dilutions. The number of viable cells was counted and production of HIV p24 assessed on days 3, 7, 11, and 14 of experiment. Myramistin in a concentration of 100 micrograms/ml prevented the replication of HIV-1 in indicator cells. Addition of 0.50 microgram/ml of myramistin to culture fluid led to 1000-fold drop of virus infectivity. These results are in line with previous reports about dose-dependent inhibition of cell-associated HIV with the above detergent.
Iu L
IuL
Krivorutchenko
D019380:Anti-HIV Agents / Q000494:pharmacology*; D001548:Benzalkonium Compounds / Q000494:pharmacology*; D003902:Detergents; D004305:Dose-Response Relationship, Drug; D016655:HIV Core Protein p24 / Q000032:analysis; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D019169:Jurkat Cells; D014779:Virus Replication / Q000187:drug effects
D019380:Anti-HIV Agents; D001548:Benzalkonium Compounds; D003902:Detergents; D016655:HIV Core Protein p24; C058048:miramistin