[A measure to continue intra-arterial infusion chemotherapy long-term for locally advanced pancreatic cancer].
For locally advanced non-resectable cancer of the pancreas, we have routinely performed intra-arterial chemotherapy: Each catheter is placed in the splenic artery and gastroduodenal artery during laparotomy, and a mixture of Methotrexate and Angiotensin-II is infused within 30 minutes. This treatment is repeated weekly at our outpatient clinic as long as possible. However, obstruction of the catheter or corresponding artery is the major cause of interruption of treatment. The present paper reports a case in which intra-arterial chemotherapy was possible by repeated catheterization for the catheter obstruction. A 54-year-old woman with non-resectable pancreatic cancer underwent catheter placement during laparotomy, but they became occluded one month later. Another catheter was placed into the common hepatic artery by the Seldinger method. After this catheter was occluded again, another catheter was placed into the inferior pancreaticoduodenal artery via the superior mesenteric artery by the Seldinger method. By repeating this catheter placement, we succeeded in continuing the intra-arterial chemotherapy, and the patient has remained alive (30 postoperative months) without losing her quality of life.
Dept. of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases.
H
H
Ohigashi
O
O
Ishikawa
H
H
Nakano
Y
Y
Sasaki
K
K
Murata
T
T
Yasuda
M
M
Kameyama
M
M
Hiratsuka
T
T
Kabuto
H
H
Furukawa
S
S
Imaoka
A
A
Nakaizumi
H
H
Uehara
N
N
Hosomi
M
M
Fujita
C
C
Kuroda
D000804:Angiotensin II / Q000008:administration & dosage*; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D002408:Catheters, Indwelling; D004334:Drug Administration Schedule; D005260:Female; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D015918:Infusion Pumps, Implantable; D007261:Infusions, Intra-Arterial / Q000379:methods; D008727:Methotrexate / Q000008:administration & dosage*; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000188:drug therapy*
D000964:Antimetabolites, Antineoplastic; D000804:Angiotensin II; D006493:Heparin; D008727:Methotrexate