Acute myocardial infarction with large bilateral intracoronary thrombi in a young patient with the prothrombin 20210 G-->A mutation.
A genetic variation in the 3'-UT region of the prothrombin gene, a G to A mutation at nucleotide 20210, has been associated recently with increased risk of acute myocardial infarction. We describe a case of a young patient carrying the mutation, with an AMI caused by large bilateral intracoronary thrombi, that underwent direct PTCA.
Department of Cardiology, Academic Medical Center, University of Amsterdam, The Netherlands. r.j.dewinter@amc.uva.nl
R J
RJ
de Winter
S
S
Middeldorp
S
S
Gaffar
K T
KT
Koch
J J
JJ
Piek
M
M
Levi
P H
PH
Reitsma
D000328:Adult; D001483:Base Sequence / Q000235:genetics; D017023:Coronary Angiography; D003328:Coronary Thrombosis / Q000097:blood / Q000235:genetics* / Q000628:therapy; D004252:DNA Mutational Analysis; D004562:Electrocardiography; D006580:Genetic Carrier Screening; D014644:Genetic Variation; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000097:blood / Q000235:genetics* / Q000628:therapy; D009710:Nucleotide Mapping; D010375:Pedigree; D011516:Prothrombin / Q000235:genetics* / Q000378:metabolism; D019851:Thrombophilia / Q000097:blood / Q000235:genetics* / Q000628:therapy
D011516:Prothrombin