Biologically active oligodeoxyribonucleotides. 10: anti-HIV-1 activity and stability of modified hexanucleotides containing glycerol-skeleton.
Deoxyribose-moieties of modified hexadeoxyribonucleotide 1, which exhibits anti-HIV-1 activity, were partially replaced with glycerol-moieties. Compound 7 with two glycerylguanines at its 3'-end showed more potent anti-HIV-1 activity and more stability against digestion by nucleases than the parent compound 1.
Exploratory Chemistry Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan. hotoda@shina.sankyo.co.jp
H
H
Hotoda
M
M
Koizumi
T
T
Ohmine
H
H
Furukawa
T
T
Nishigaki
K
K
Abe
T
T
Kosaka
S
S
Tsutsumi
J
J
Sone
M
M
Kaneko
D000818:Animals; D019380:Anti-HIV Agents / Q000138:chemical synthesis*; D002460:Cell Line; D002942:Circular Dichroism; D003851:Deoxyribonucleases / Q000378:metabolism; D005990:Glycerol / Q000031:analogs & derivatives*; D015497:HIV-1 / Q000472:pathogenicity; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
D019380:Anti-HIV Agents; D009838:Oligodeoxyribonucleotides; D003851:Deoxyribonucleases; D005990:Glycerol