Effect of fantofarone, a new Ca2+ channel antagonist, on angioplasty-induced vasospasm in an atherosclerotic rabbit model.
In order to prevent and treat angioplasty-induced vasospasm, we investigated the effects of a new Ca2+ channel antagonist, fantofarone, a nondihydropyridine compound with a novel site of action on the L-type Ca2+ channel, in an animal model of angioplasty in rabbits with femoral atherosclerotic lesions. Vasospasm which occurred in saline-treated animals following angioplasty was markedly reduced by fantofarone (50 microg/kg, i.v.) at both the distal and proximal sites. Although it totally inhibited distal vasospasm, isosorbide dinitrate (0.3 mg/kg, i.v.) did not significantly affect proximal diameter decrease. Verapamil (0.2 mg/kg, i.v.) was much less potent than fantofarone in reducing angioplasty-induced vasospasm. Our results confirm the preventive effects of Ca2+ blockers on this phenomenon and extend this observation to a potent compound: fantofarone.
Dongay
B
B
Haemobiology Research Department, Sanofi Recherche, Toulouse, France.
Dol-Gleizes
F
F
Herbert
J M
JM
D017130:Angioplasty; D000818:Animals; D001161:Arteriosclerosis / Q000503:physiopathology* / Q000601:surgery*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D005263:Femoral Artery / Q000187:drug effects / Q000473:pathology; D007212:Indolizines / Q000494:pharmacology*; D008297:Male; D010627:Phenethylamines / Q000494:pharmacology*; D011817:Rabbits; D014665:Vasodilator Agents / Q000494:pharmacology*; D014700:Verapamil / Q000494:pharmacology
D002121:Calcium Channel Blockers; D007212:Indolizines; D010627:Phenethylamines; D014665:Vasodilator Agents; D014700:Verapamil; C059901:fantofarone