N lines in a myopathy with myosin loss.
N lines can be seen by electron microscopy within the I band of skeletal muscle, but are poorly visualized in conventional preparations. We present a case of acute quadriplegic myopathy with myosin loss and prominent N lines. The only other reported cases of N lines were also seen in patients with myosin loss from diverse etiologies. Myosin loss and the subsequent detachment of titin from myosin may result in the formation of prominent N lines.
Washington University Department of Neurology, St. Louis, Missouri 63110, USA.
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D004568:Electrodiagnosis; D006801:Humans; D007366:Intercostal Muscles / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D018485:Muscle Fibers, Skeletal / Q000473:pathology; D009135:Muscular Diseases / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism* / Q000473:pathology*; D009218:Myosins / Q000378:metabolism*; D009460:Neurologic Examination; D011782:Quadriplegia / Q000150:complications
D009218:Myosins