On the nature of "HLA-B42" alloantibodies. Specific reagents for HLA-Cw*17?
An almost complete and bidirectional association exists between HLA-Cw*17 and the HLA-B antigens B41 and B42. Serological and molecular analysis of an individual in which HLA-B*4101 was identified in the absence of Cw*17 provides experimental evidence to prove a previously proposed hypothesis predicting that alloantisera classified as "B41+B42" are instead specific reagents for HLA-Cw*17.
Servicio de Immunología, H.U. Clínica Puerta de Hierro, Madrid, Spain.
M J
MJ
Herrero
M
M
Bunce
M
M
van Dam
R
R
de Pablo
C
C
Vilches
D000595:Amino Acid Sequence; D000918:Antibody Specificity; D015235:HLA-B Antigens / Q000235:genetics / Q000276:immunology*; D015236:HLA-C Antigens / Q000276:immunology*; D006801:Humans; D007518:Isoantibodies / Q000276:immunology*; D015810:Linkage Disequilibrium; D008969:Molecular Sequence Data
D015235:HLA-B Antigens; C056322:HLA-B41 antigen; D015236:HLA-C Antigens; D007518:Isoantibodies