Cytogenetic abnormalities in primary bronchopulmonary leiomyosarcoma of childhood.
Primary bronchopulmonary leiomyosarcoma (PBLMS) is a rare malignant neoplasm in all age groups and only 10 pediatric cases of PBLMS have been reported. This report presents cytogenetic findings of a PBLMS from an 8-year-old boy. Tumor diagnosis was established by using routine histopathology, immunohistochemistry, and electron microscopy. The karyotype was highly complex, demonstrating consistent structural abnormalities of chromosomes 1, 5, 6, and 7, relative gain of chromosomes 2 and 11, and relative loss of chromosomes 9, 19, 20, and 22, along with the presence of multiple marker chromosomes. Cytogenetic results of previously reported leiomyosarcomas are reviewed and compared with the present case.
Department of Radiation Oncology, University of Virginia, Charlottesville 22908, USA.
B F
BF
Schneider
M A
MA
Lovell
W L
WL
Golden
D002648:Child; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007621:Karyotyping; D007890:Leiomyosarcoma / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D008297:Male