Protective role of Trianthema portulacastrum against diethylnitrosoamine-induced experimental hepatocarcinogenesis.
The chemopreventive efficacy of the Indian medicinal plant Trianthema portulacastrum L. Aizoaceae was tested in a chemical rat hepatocarcinogenesis model in male Sprague-Dawley rats. Hepatocarcinogenesis was induced by the potent carcinogen diethylnitrosoamine (DENA). Treatment of the rats to the basal medium with aqueous, ethanolic and chloroform fractions of the plant extract at a dose of 100 mg/kg body weight once daily reduced the incidence, numerical preponderance, multiplicity and size distribution of visible neoplastic nodules. Morphometric evaluation of focal lesions showed a reduction of altered liver cell foci/cm2 and a reduction of the average focal area. A decrease in the percentage of liver parenchyma occupied by foci seems to suggest the anticarcinogenic potential of the plant extract in DENA-induced hepatocarcinogenesis.
Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
S
S
Bhattacharya
M
M
Chatterjee
D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D002273:Carcinogens / Q000633:toxicity*; D004052:Diethylnitrosamine / Q000633:toxicity*; D004327:Drinking Behavior / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced* / Q000517:prevention & control*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley
D016588:Anticarcinogenic Agents; D002273:Carcinogens; D010936:Plant Extracts; D004052:Diethylnitrosamine