A new method for plasma volume measurements with unlabeled dextran-70 instead of 125I-labeled albumin as an indicator.
A method has been developed to determine plasma volume with dextran-70 without the use of a fluorescent label. The results obtained are compared to those found using the 125I-labeled albumin method, which is taken as the gold standard. The CV of the method is about 5%, compared to 3% with the gold standard. It is shown to be of use for the determination of an increase in plasma volume during pregnancy.
Department of Clinical Chemistry, Academic Hospital Maastricht, Netherlands.
B K
BK
van Kreel
E
E
van Beek
M E
ME
Spaanderman
L L
LL
Peeters
D003911:Dextrans; D005260:Female; D005947:Glucose; D006801:Humans; D007201:Indicator Dilution Techniques; D007457:Iodine Radioisotopes; D007467:Iodoproteins; D010953:Plasma Volume; D011247:Pregnancy; D012680:Sensitivity and Specificity; D012709:Serum Albumin; D015003:Yeasts
D003911:Dextrans; D007457:Iodine Radioisotopes; D007467:Iodoproteins; D012709:Serum Albumin; D005947:Glucose