The growth of brown adipose tissue in cold-acclimatized rats after depletion of mast cell histamine by compound 48/80.
Cold acclimatization (4-5 degree C) is accompanied by 2-3 fold increase of brown adipose tissue (BAT). This rapid growth of interscapular BAT was studied after histamine depletion. In control rats maintained at room temperature (28 +/- 2 degree C) the BAT histamine content was 23.4 +/- 5.9 (mean +/- SD) microgram/g of tissue and cold acclimatization (5 +/- 1 degree C) produced a significant increase of BAT weight, but reduced the histamine content to 8.4 +/- 1.9 microgram/g. The total weight of BAT after 20 days of acclimatization was unaffected by depletion of histamine due to compound 48/80. The low level of histamine in BAT of cold acclimatized rats could be due to a fast rate of amine utilization; alternatively an altered synthesis or storage process may occur during acclimatization.
Unidad de Investigación en Ciencias Funcionales, Escuela de Ciencias Veterinarias, Universidad Centroccidental Lisandro Alvarado, Barquisimeto, Venezuela.
N L
NL
Daló
A A
AA
López-Ortega
H
H
Moussatché
D000064:Acclimatization / Q000502:physiology*; D002001:Adipose Tissue, Brown / Q000378:metabolism* / Q000502:physiology*; D000818:Animals; D003080:Cold Temperature; D005260:Female; D006632:Histamine / Q000378:metabolism; D006636:Histamine Release / Q000187:drug effects*; D008407:Mast Cells / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D003189:p-Methoxy-N-methylphenethylamine / Q000008:administration & dosage* / Q000494:pharmacology
D003189:p-Methoxy-N-methylphenethylamine; D006632:Histamine