Association of the Trp64Arg mutation of the beta3-adrenergic receptor with fatty liver and mild glucose intolerance in Japanese subjects.
The prevalence of a mutation of the codon for tryptophan 64 to arginine (Trp64Arg) in the beta3-adrenergic receptor gene was investigated by genotyping 261 Japanese subjects. The allelic frequency of this mutation was 0.18. Subjects with the homozygous W64R mutant alleles had a significantly higher prevalence of fatty liver, BMI, serum gamma-glutamyl transpeptidase, and serum leucine amino transpeptidase levels than those without the mutation. Individuals with this mutation also showed a higher fasting blood glucose level than those without this mutation. However, the prevalence of diabetes mellitus was no different between the three groups. These results suggest a potential association of the Trp64Arg mutation with higher morbidity of fatty liver and mild glucose intolerance.
Shima
Y
Y
Laboratory of Biochemistry, Kyorin University School of Health Sciences, Hachioji, Tokyo, Japan. shimashi@kyorin-u.ac.jp
Tsukada
T
T
Nakanishi
K
K
Ohta
H
H
D000483:Alleles; D001120:Arginine / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D005234:Fatty Liver / Q000150:complications / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D018149:Glucose Intolerance / Q000150:complications / Q000235:genetics*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D009154:Mutation; D009765:Obesity / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length; D011943:Receptors, Adrenergic, beta / Q000235:genetics*; D022702:Receptors, Adrenergic, beta-3; D014364:Tryptophan / Q000235:genetics*
D011943:Receptors, Adrenergic, beta; D022702:Receptors, Adrenergic, beta-3; D014364:Tryptophan; D001120:Arginine