[Rapid tapering of cyclosporine for cytogenetic relapse shortly after bone marrow transplantation in a patient with chronic myeloid leukemia].
A 53-year-old female case of cytogenetically relapsed chronic myeloid leukemia after allogeneic bone marrow transplantation (BMT) who achieved remission by withdrawal of immunosuppressant is reported. On day 690 of this presentation she is well and alive with performance status of 100%. She had episodes of cyclic oscillation of her neutrophil count during hydroxyurea therapy lasting 1 year before transplantation. Increase of the neutrophils at the time of BMT might have contributed to her early relapse on day 207. Withdrawal of immunosuppressant was successful at least in this case.
Department of Medical Oncology, National Cancer Center Hospital.
Y
Y
Kobayashi
M
M
Nakata
N
N
Sato
Y
Y
Kamiya
A
A
Maeda
K
K
Togitani
N
N
Kawahigashi
T
T
Murayama
T
T
Yokozawa
K
K
Takeyama
M
M
Narabayashi
T
T
Takenaka
K
K
Tobinai
D016026:Bone Marrow Transplantation; D016572:Cyclosporine / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics / Q000628:therapy*; D008875:Middle Aged; D010677:Philadelphia Chromosome
D007166:Immunosuppressive Agents; D016572:Cyclosporine