Adsorption of technetium-99m tetrofosmin and technetium-99m furifosmin on plastic syringes.
Some groups have reported that adsorption of radiopharmaceuticals on disposable plastic syringes can reach levels of almost 50%. This high loss of radioactivity stimulated us to carry out similar studies. Our measurements were done in combination with patient studies. Therefore, we used 2-ml syringes, all of the same brand. The radioactivity in the syringe was measured immediately before and after injection. a total of 500-600 MBq technetium-99m labelled tetrofosmin or technetium-99m furifosmin was administered to 48 patients using four different injection techniques (n = 6 for each technique with each tracer): with needles, 1 min blood incubation at 22 degrees C, 10 or 30 min after preparation of the tracer; with butterflies, 1 min blood incubation at 22 degrees C, 10 or 30 min after preparation of the tracer. Neither in syringes nor in needles or butterflies did more than 7% of the initial radioactivity remain. The entire residual activity in syringe plus needle or syringe plus butterfly together never exceeded the 9% limit. Furthermore, in a pilot study we measured the remaining radioactivity in the vial; here, too, we found no more than 14% of total radioactivity. These findings indicate that total retention of radioactivity during elution and application of 99mTc-tetrofosmin and 99mTc-furifosmin with material used in our setting does not approach relevant amounts.
Department of Nuclear Medicine, University of Vienna, Austria.
R
R
Bartosch
S
S
Granegger
H
H
Sinzinger
D000327:Adsorption; D005663:Furans; D006801:Humans; D009339:Needles; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D010865:Pilot Projects; D010969:Plastics; D019275:Radiopharmaceuticals; D013594:Syringes
D005663:Furans; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D010969:Plastics; D019275:Radiopharmaceuticals; C078496:technetium Tc 99m Q12; C078700:technetium tc-99m tetrofosmin