An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators.
A number of S-nitrosated compounds derived from 1-thiosugars (glucose, galactose, xylose, maltose, and lactose) have been prepared and characterized. Most of the compounds obtained were unstable either as solids or in solution. However, S-nitroso-1-thio-2,3,4,6-tetra-O-acetylglucopyranose was stable enough to examine as a vasodilator using an isolated rat tail artery model. It also proved effective in human cutaneous vascular smooth muscle relaxation when delivered transdermally.
Butler
A R
AR
School of Chemistry and Centre for Biomolecular Sciences, University of St Andrews, Fife, Scotland, United Kingdom.
Field
R A
RA
Greig
I R
IR
Flitney
F W
FW
Bisland
S K
SK
Khan
F
F
Belch
J J
JJ
D000818:Animals; D001158:Arteries / Q000187:drug effects / Q000502:physiology; D002241:Carbohydrates / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009603:Nitroso Compounds / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013623:Tail / Q000098:blood supply; D014665:Vasodilator Agents / Q000737:chemistry / Q000494:pharmacology*
D002241:Carbohydrates; D009603:Nitroso Compounds; D014665:Vasodilator Agents