[The effect of selenium and vitamin E on the healing process of experimental corneal lesions in the eye of the rabbit].
OBJECTIVE
Evaluation of antioxidants: selenium and vitamin E efficacy in the treatment of experimental corneal lesion.


METHODS
Solution of selenium in 0.9% NaCl, concentration 0.01 g/L, to which vitamin E was added to obtain suspension of 2.5 g/L was used in 9 rabbits. The cornea was damaged by removing the epithelium from the central area of 7 mm diameter. To the right eye selenium solution with vitamin E was instilled.


RESULTS
In two eyes in which antioxidants were used evident prompt healing of corneal ulceration was noticed. Mean lesion diameter in eyes treated with antioxidants was: on 1st day 5.44 mm, in 2nd day 1.61 mm and on the 3rd day 0.33 mm. In control eyes diameters were: 6.67 mm, 2.28 mm and 0.56 mm, respectively.


CONCLUSIONS
Solution used in our study was tolerated very well. Faster healing process was noticed in eyes where antioxidants were used.
Zakładu Farmacji Aptecznej Studium Farmaceutycznego, Centrum Medycznego Kształcenia Podyplomowego w Bydgoszczy.
E
E
Sieradzki
E
E
Olejarz
K
K
Strauss
A
A
Marzec
M
M
Mieszkowska
J
J
Kałuzny
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D003315:Cornea / Q000187:drug effects*; D065306:Corneal Injuries; D003320:Corneal Ulcer / Q000188:drug therapy; D004359:Drug Therapy, Combination; D005131:Eye Injuries / Q000188:drug therapy; D007322:Instillation, Drug; D011817:Rabbits; D012643:Selenium / Q000008:administration & dosage*; D014810:Vitamin E / Q000008:administration & dosage*; D014945:Wound Healing / Q000187:drug effects*
D000975:Antioxidants; D014810:Vitamin E; D012643:Selenium