Genomic and phylogenetic analysis of hepatitis C virus strains from Argentina.
HCV genomic characterization was performed by nucleotide sequence analysis (n=50) combined with restriction fragment length polymorphism (RFLP) of the 5' UTR region in 82 isolates corresponding to different Argentine groups. Genotype 1 was detected in 70.7% of the samples (58 out of 82), genotype 2 in 21.9% (18 of 82) and genotype 3 in the remaining 6 sera (7.3%). HCV 1b subtype contributed with 35.3% to the whole population studied (29 to 82) and was detected in 6 out of 21 sporadic cases. Besides their epidemiological significance, these results should be taken into account when future vaccines are considered on the basis of geographical HCV genotypic prevalence.
Quarleri
J F
JF
Departmento de Microbiologia, Parasitologia e Inmunologia, Facultad de Medicina, Universidad de Buenos Aires, Argentina.
Robertson
B H
BH
Mathet
V
V
Sinha
S D
SD
Badía
I
I
Frider
B
B
Ferro
A
A
Galoppo
C
C
Sookoian
S
S
Castaño
G
G
Oubiã
J R
JR
D000293:Adolescent; D000328:Adult; D000368:Aged; D001118:Argentina; D001483:Base Sequence; D002648:Child; D002675:Child, Preschool; D005260:Female; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics*; D019698:Hepatitis C, Chronic / Q000097:blood* / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors; D017423:Sequence Analysis, RNA