Peripheral neuroblastoma and primitive neuroectodermal tumor in Japanese black cattle.
Peripheral neuroblastoma was found in a 1-year-old, male, Japanese black cattle (Case 1) and primitive neuroectodermal tumor was noted in 7-year-old, female, Japanese black cattle (Case 2). In Case 1, neoplastic tissue was replaced the right cranial vault and nasopharynx. A large, soft mass approximately 18 cm in diameter was also observed in the right mandibulopharyngeal area. In Case 2, a neoplastic mass of about 15 cm in diameter was found in the mandibulopharyngeal area. Histopathologically, massive necrosis showing a pseudopalisade arrangement was frequently observed in Case 1. On the contrary, Homer & Wright rosette formations of tumor cells were prominent in Case 2. Immunohistochemically, the proliferating cells in Case 1 were positive for vimentin, S-100, and neurofilament (NF) and those in Case 2 showed intense immunoreactivity for NF and neuron specific enolase, but were negative for vimentin and S-100. The different degrees of differentiation of the neoplastic cells originating from the neuroectoderm, might be reflected in their different morphological and immunohistochemical features.
Department of Veterinary Pathology, Miyazaki University, Japan.
K
K
Uchida
T
T
Murakami
T
T
Tometsuka
A
A
Iwakiri
R
R
Yamaguchi
S
S
Tateyama
D000818:Animals; D001932:Brain Neoplasms / Q000473:pathology / Q000662:veterinary*; D002417:Cattle; D002418:Cattle Diseases / Q000473:pathology*; D005065:Euthanasia / Q000662:veterinary; D005260:Female; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000473:pathology / Q000662:veterinary*; D009336:Necrosis; D009447:Neuroblastoma / Q000473:pathology / Q000662:veterinary*; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000473:pathology / Q000662:veterinary*; D016900:Neurofilament Proteins / Q000032:analysis; D014746:Vimentin / Q000032:analysis
D016900:Neurofilament Proteins; D014746:Vimentin