Synthesis and biological activity of bis(pivaloyloxymethyl) ester of 2'-azido-2'-deoxyuridine 5'-monophosphate.
Bis(pivaloyloxymethyl) ester of 2'-azido-2'-deoxyuridine 5'-monophosphate was prepared as a prodrug to generate 2'-azido-2'-deoxyuridine 5'-diphosphate inside the cell. A synthetic route utilizing stannyl phosphate was adopted in the preparation. The prodrug was evaluated for cell growth inhibition against a variety of tumor cell lines along with 2'-azido-2'-deoxyuridine and 2'-azido-2'-deoxycytidine.
School of Pharmacy, University of North Carolina, Chapel Hill 27514, USA.
S H
SH
Kang
A K
AK
Sinhababu
M J
MJ
Cho
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001386:Azides / Q000138:chemical synthesis* / Q000494:pharmacology*; D016466:CHO Cells; D006224:Cricetinae; D003856:Deoxyuracil Nucleotides / Q000138:chemical synthesis* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D009682:Magnetic Resonance Spectroscopy; D014407:Tumor Cells, Cultured
C114287:2'-azido-2'-deoxyuridine 5-monophosphate bis(pivaloyloxymethyl) ester; D000970:Antineoplastic Agents; D001386:Azides; D003856:Deoxyuracil Nucleotides