Cutaneous fibrous perineurioma.
Tumors of perineurial origin are rare. Three variants of perineuriomas have been described, a storiform perineurial fibroma, an intraneural perineurioma, and a recently described sclerosing perineurioma. We present two patients with cutaneous fibrous perineurioma located in acral areas. Both tumors had a deep circumscribed margin with a prominent vascular component. They contained small round cells and spindle cells that express EMA and show membrane staining for type IV collagen. Cutaneous fibrous perineuriomas fit within the spectrum of neurocristicly derived cellular proliferations.
National Naval Medical Center, Bethesda, Maryland 20889-5600, USA.
K
K
Smith
H
H
Skelton
D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008854:Microscopy, Electron; D010525:Peripheral Nerves; D010524:Peripheral Nervous System Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D012983:Soft Tissue Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure
D014408:Biomarkers, Tumor