Eye malformations associated with treatment with carbamazepine during pregnancy.
Four children are presented and their eye malformations described. One girl had bilateral anophthalmos, a boy and a girl had bilateral severe microphthalmos, and a boy had a unilateral optic disc coloboma. The mothers of all for children were treated with carbamazepine during pregnancy. The teratogenic effect of carbamazepine and its likely role in the genesis of the eye malformations is discussed.
Sutcliffe
A G
AG
Department of Pediatrics, Moorfields Eye Hospital, London, UK.
Jones
R B
RB
Woodruff
G
G
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000927:Anticonvulsants / Q000009:adverse effects*; D002220:Carbamazepine / Q000009:adverse effects*; D003103:Coloboma / Q000139:chemically induced* / Q000000981:diagnostic imaging; D005124:Eye Abnormalities / Q000139:chemically induced*; D005260:Female; D005333:Fetus / Q000187:drug effects; D005865:Gestational Age; D006801:Humans; D008297:Male; D009898:Optic Disk / Q000002:abnormalities* / Q000000981:diagnostic imaging; D011247:Pregnancy; D014463:Ultrasonography
D000927:Anticonvulsants; D002220:Carbamazepine