Pain: nocistatin spells relief.
Tissue or nerve injury can dramatically alter the transmission of sensory stimuli by spinal cord neurons, so that a light touch produces pain. The discovery that peptide products of prepronociceptin processing either facilitate or inhibit these mechanisms suggests novel approaches to treating these conditions.
Department of Anatomy, University of California at San Francisco 94143-0452, USA.
W J
WJ
Martin
A B
AB
Malmberg
A I
AI
Basbaum
D000701:Analgesics, Opioid / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D009437:Neuralgia / Q000188:drug therapy*; D018847:Opioid Peptides / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D010147:Pain Measurement; D011493:Protein Kinase C / Q000378:metabolism; D011957:Receptors, Opioid / Q000378:metabolism; D000094942:Nociceptin Receptor
D000701:Analgesics, Opioid; D007527:Isoenzymes; D018847:Opioid Peptides; D011957:Receptors, Opioid; C111148:nocistatin; C087857:protein kinase C gamma; D011493:Protein Kinase C; D000094942:Nociceptin Receptor; C000722283:OPRL1 protein, human