Room-temperature phosphorimetric method for the determination of the drug naphazoline in pharmaceutical preparations.
A selective and sensitive micelle-stabilized room-temperature phosphorimetric (MS-RTP) method for the determination of naphazoline in pharmaceutical preparations is described. The method is based on obtaining a phosphorescence signal from naphazoline using a micellar agent (sodium dodecyl sulfate), a heavy atom salt (TINO3) and a deoxygenation agent (Na2SO3). Optimization of the various conditions permitted the establishment of an MS-RTP method for naphazoline determination with a detection limit of 64.2 ng ml-1 and a relative standard deviation of 3.74% at the 500 ng ml-1 level. The method was applied to the analysis of pharmaceutical preparations.
Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Spain.
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Segura Carretero
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Cruces Blanco
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Cañabate Díaz
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Fernández Gutiérrez
D000316:Adrenergic alpha-Agonists / Q000032:analysis*; D049449:Luminescence; D009278:Naphazoline / Q000032:analysis*; D004364:Pharmaceutical Preparations / Q000737:chemistry*
D000316:Adrenergic alpha-Agonists; D004364:Pharmaceutical Preparations; D009278:Naphazoline