Comparative genomic hybridization studies in tumours from a patient with multiple endocrine neoplasia type 1.
OBJECTIVE
To identify genetic changes, other than the MEN1 gene, that might be involved in the tumorigenesis and progression of multiple endocrine neoplasia type 1 (MEN1)-related tumours.


METHODS
We used comparative genomic hybridization (CGH) and loss of heterozygosity (LOH) to study tumours from various sites in a patient with MEN1.


RESULTS
Gain of genetic material was not found. Frequent losses of genetic material were found in chromosomes 1, 4, 5, 6, 9, 11 and 18. Besides the chromosome 11 where the MEN1 gene is located, the other regions are known to harbour important tumour suppressor genes.


CONCLUSIONS
These results suggest the involvement of other cancer-related genes in the tumorigenesis and progression of MEN1 tumours that warrant further investigations.
Kytölä
S
S
Department of Clinical Genetics, Oulu University Hospital, Finland.
Mäkinen
M J
MJ
Kähkönen
M
M
Teh
B T
BT
Leisti
J
J
Salmela
P
P
D000310:Adrenal Gland Neoplasms / Q000235:genetics; D002877:Chromosomes, Human / Q000235:genetics; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D018628:Gene Dosage; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000556:secondary; D019656:Loss of Heterozygosity; D008207:Lymphatic Metastasis; D008875:Middle Aged; D018761:Multiple Endocrine Neoplasia Type 1 / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D009693:Nucleic Acid Hybridization; D010282:Parathyroid Neoplasms / Q000235:genetics; D013274:Stomach Neoplasms / Q000235:genetics
D004273:DNA, Neoplasm