Hypertrophic cardiomyopathy with type I CD36 deficiency.
CD36 is a multifunctional membrane-type receptor glycoprotein that reacts with oxidized low-density lipoprotein and long-chain fatty acid (LCFA). A patient presented with hereditary hypertrophic cardiomyopathy (HCM) and type I CD36 deficiency (neither platelets nor monocytes expressed CD36) but showed no myocardial LCFA accumulation. CD36 was expressed in the capillary endothelial cells of the cardiac muscle of a control subject, while the patient's myocardial capillary endothelial cells were completely CD36-negative. These results suggest that type I CD36 deficiency is closely related to hereditary HCM and lack of myocardial LCFA accumulation.
Watanabe
K
K
Clinical Pharmacology, Niigata College of Pharmacy, Japan. watanabe@niigata-pharm.ac.jp
Toba
K
K
Ogawa
Y
Y
Kodama
M
M
Hirono
S
S
Ohkura
Y
Y
Hanawa
H
H
Nakamura
Y
Y
Aoki
Y
Y
Fuse
I
I
Aizawa
Y
Y
Miyajima
S
S
Kusano
Y
Y
Nagatomo
T
T
Hasegawa
G
G
Naito
M
M
D018955:CD36 Antigens / Q000378:metabolism*; D002312:Cardiomyopathy, Hypertrophic / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*
D018955:CD36 Antigens