[Adjuvant chemotherapy in the combined treatment of primary circumscribed malignant melanoma of the skin].
Results are analyzed of employment of different methods of adjuvant chemotherapy in patients with melanoma of the skin of the extremities and trunk. The courses of systemic prophylactic chemotherapy failed to improve results of surgical treatment of primary circumscribed melanoma of the skin. Adjuvant systemic chemotherapy and the immunomodulating agent levomizole combined in treatment of the condition did not change indices for late results of the treatment. The postoperative endolymphatic chemotherapy appeared to be associated with statistically significant (11.4%) increase in indices for a 5-year survival of patients with melanoma of the skin of the extremities and trunk.
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Korovin
D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D009367:Neoplasm Staging; D011182:Postoperative Care / Q000379:methods; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D013997:Time Factors