Interleukin 6 is a cause of flu-like symptoms in treatment with a deoxycytidine analogue.
The precise mechanism of fever and flu-like syndrome that occurs in treatment with deoxycytidine analogues remains unclear. This study demonstrated a strong correlation between plasma interleukin 6 levels and fever in treatment with oral (E)-2'-deoxy-2'(fluoromethylene)cytidine, another deoxycytidine analogue.
Department of Internal Medicine, Osaka Prefectural Habikino Hospital, Japan.
N
N
Masuda
S
S
Negoro
K
K
Takeda
N
N
Kurata
T
T
Kuwabara
S
S
Kobayashi
M
M
Fukuoka
D000284:Administration, Oral; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects; D003841:Deoxycytidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D005334:Fever / Q000209:etiology*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*
D000970:Antineoplastic Agents; D015850:Interleukin-6; D003841:Deoxycytidine; C086432:tezacitabine