Sequences and expression of six new members of the tetraspanin/TM4SF family.
Tetraspanins (or TM4SF) are expressed in a wide variety of species and regulate cell adhesion, migration, proliferation and differentiation. We have identified and sequenced six new members of the tetraspanin family, called Tspan-1-6, from human cDNA. Amino acid sequence analysis of the Tspans highlights conserved residues which may be critical to tetraspanin structure and function. The Tspans are differentially expressed in human tissues.
Todd
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SC
Stanford University Medical Center, Department of Medicine, CA 94305, USA.
Doctor
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VS
Levy
S
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D000595:Amino Acid Sequence; D018076:DNA, Complementary / Q000737:chemistry / Q000302:isolation & purification*; D015723:Gene Library; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics*; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
D018076:DNA, Complementary; D008565:Membrane Proteins