Motilin increases food intake in mice.
The effect of motilin on food intake was investigated in nonfood-deprived mice. A significant increase in food intake was observed 1 h after ICV administration of motilin (3 nmol/mouse) and continued for 2 h. This effect was attenuated markedly by the motilin receptor antagonist GM-109 (0.3-3 nmol/mouse) in a dose-related manner. GM-109 alone had no effect on food intake. These results indicate that motilin receptors are present in the brain and may have a role in the regulation of food intake.
Second Department of Internal Medicine, Kobe University School of Medicine, Japan.
A
A
Asakawa
A
A
Inui
K
K
Momose
N
N
Ueno
M A
MA
Fujino
M
M
Kasuga
D000818:Animals; D002149:Energy Intake / Q000187:drug effects*; D006727:Hormone Antagonists / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D009037:Motilin / Q000008:administration & dosage / Q000494:pharmacology*; D010456:Peptides, Cyclic / Q000494:pharmacology; D013552:Swine
C093574:GM 109; D006727:Hormone Antagonists; D010456:Peptides, Cyclic; D009037:Motilin