A synthetic calcium-chelating L-glutamyl-L-serine phosphate (Glu-Ser.P) enhances calcium absorption in the rat.
A new synthetic procedure was used to prepare L-glutamyl-L-serine phosphate (Glu-Ser.P) with a good yield. The phosphopeptide is able to chelate calcium ion as shown by conductimetric titration and through the use of a calcium-specific electrode. Intestinal absorption of radioactive calcium is enhanced in rats fed 45Ca and Glu-Ser.P.
Department of Biological Chemistry, University of Padova, Italy. gal@civ.bio.unipd.it
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Galzigna
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Domergue
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Previero
D000284:Administration, Oral; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002132:Calcium Radioisotopes / Q000378:metabolism; D002614:Chelating Agents / Q000737:chemistry*; D004151:Dipeptides / Q000737:chemistry*; D004553:Electric Conductivity; D007408:Intestinal Absorption / Q000187:drug effects; D010748:Phosphopeptides / Q000737:chemistry*; D051381:Rats
D002132:Calcium Radioisotopes; D002614:Chelating Agents; D004151:Dipeptides; D010748:Phosphopeptides; D002118:Calcium