PACAP colocalizes with luteinizing and follicle-stimulating hormone immunoreactivities in the anterior lobe of the pituitary gland.
Pituitary adenylate cyclase activating polypeptide (PACAP) and its close relative vasoactive intestinal polypeptide (VIP) were demonstrated in the anterior pituitary gland. The cells which exhibited PACAP immunoreactivity were oval or round shaped. Their distribution was similar to that of gonadotropes but the number of PACAP immunoreactive cells was less. Double labeling revealed that PACAP immunoreactivity partially colocalized with luteinizing and follicle-stimulating hormone; however, colocalization with other pituitary hormone immunoreactivities was not demonstrated. Our results suggest an autocrine or paracrine role of PACAP in the regulation of pituitary functions.
Department of Human Morphology and Developmental Biology, Semmelweis University Medical School, Budapest, Hungary. Koves@ana2.sote.hu
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Köves
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Kántor
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Scammell
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Arimura
D000818:Animals; D004971:Estrus; D005260:Female; D005640:Follicle Stimulating Hormone / Q000032:analysis*; D007150:Immunohistochemistry; D007986:Luteinizing Hormone / Q000032:analysis*; D008297:Male; D009479:Neuropeptides / Q000032:analysis*; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D010903:Pituitary Gland, Anterior / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014660:Vasoactive Intestinal Peptide / Q000032:analysis
C495403:Adcyap1 protein, rat; D009479:Neuropeptides; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D014660:Vasoactive Intestinal Peptide; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone