Atrial natriuretic peptide secretion and body fluid balance after bilateral atrial appendectomy by the maze procedure.
OBJECTIVE
One of the earliest recognized postoperative complications of the maze procedure was the fluid retention in the immediate postoperative period. Routine postoperative administration of diuretics markedly reduces the frequency and severity of the fluid retention. However, the cause of the abnormal fluid balance is still uncertain.


METHODS
We evaluated 24 patients: 15 patients underwent the maze procedure (maze group) and 9 patients did not (nonmaze group). Blood samples were obtained before and in the time course after operation for atrial natriuretic peptide measurement. To evaluate the influence of atrial natriuretic peptide on the body fluid balance, we also measured the amount of body fluid balance and the total doses of furosemide and dopamine administered after operation. To examine the effect of the maze procedure on atrial natriuretic peptide secretion in chronic phase, we measured plasma atrial natriuretic peptide levels during dynamic exercise in 21 patients who had undergone cardiac operations 2 years before.


RESULTS
Plasma atrial natriuretic peptide levels in the nonmaze group significantly increased after operation. In contrast, plasma atrial natriuretic peptide levels in the maze group did not increase, and these levels were significantly lower than in the nonmaze group. Although significantly greater doses of furosemide and dopamine were administered to the maze group than to the nonmaze group, the body fluid balance in the maze group was comparable with that in the nonmaze group in the early postoperative period. The response of atrial natriuretic peptide secretion by exercise was significantly attenuated in the maze group (n = 12) compared with the nonmaze group (n = 9) even 2 years after surgery, although there were no significant differences in heart rate or blood pressure during exercise between two groups.


CONCLUSIONS
These results suggest that the maze procedure attenuates atrial natriuretic peptide secretion in the early postoperative period and persists in chronic phase. This attenuated atrial natriuretic peptide secretion may reduce the ability of the kidneys to handle fluid load early after surgery.
Division of Hypertension and Cardiovascular Surgery, National Cardiovascular Center, Suita, Osaka, Japan.
F
F
Yoshihara
T
T
Nishikimi
Y
Y
Kosakai
F
F
Isobe
H
H
Matsuoka
S
S
Takishita
Y
Y
Kawashima
Y
Y
Saito
H
H
Matsuo
K
K
Kangawa
D001281:Atrial Fibrillation / Q000097:blood / Q000601:surgery; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000378:metabolism*; D001826:Body Fluids / Q000502:physiology*; D006348:Cardiac Surgical Procedures; D002908:Chronic Disease; D004232:Diuretics / Q000627:therapeutic use; D004298:Dopamine / Q000627:therapeutic use; D015444:Exercise / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D005665:Furosemide / Q000627:therapeutic use; D006325:Heart Atria / Q000601:surgery*; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000378:metabolism / Q000517:prevention & control
D004232:Diuretics; D005665:Furosemide; D009320:Atrial Natriuretic Factor; D004298:Dopamine