Homology modeling, model and software evaluation: three related resources.
BACKGROUND
Homology modeling is rapidly becoming the method of choice for obtaining three-dimensional coordinates for proteins because genome projects produce sequences at a much higher rate than NMR and X-ray laboratories can solve the three-dimensional structures. The quality of protein models will not be immediately clear to novices and support with the evaluation seems to be needed. Expert users are sometimes interested in evaluating the quality of modeling programs rather than the quality of the models themselves.


RESULTS
Three servers have been made available to the scientific community: a homology modeling server, a model quality evaluation server and a server that evaluates models built of proteins for which the structure is already known, thereby implicitly evaluating the quality of the modeling program.


BACKGROUND
The modeling-related servers and several structure analysis servers are freely available at http://swift.embl-heidelberg.de/servers/


BACKGROUND
gert.vriend@embl-heidelberg.de
Rodriguez
R
R
Center for Genetic Engineering and Biotechnology, Havana, Cuba and 2BIOcomputing, EMBL, Heidelberg, Germany.
Chinea
G
G
Lopez
N
N
Pons
T
T
Vriend
G
G
D019295:Computational Biology; D016208:Databases, Factual; D020407:Internet; D008958:Models, Molecular; D011506:Proteins / Q000737:chemistry* / Q000235:genetics; D015203:Reproducibility of Results; D017386:Sequence Homology, Amino Acid; D012984:Software
D011506:Proteins