Reduced IL-1 production in adolescents with mite antigen asthma in remission.
To determine the immunological mechanisms associated with outgrowing mite antigen-induced bronchial asthma during adolescence, we studied the relationship between clinical status and Dermatophagoides farinae (Df) antigen-induced peripheral cell activation by measuring IL-1alpha and IL-1beta production in patients with bronchial asthma. After antigen-driven restimulation in vitro, there was increased IL-1alpha, IL-1beta production by peripheral blood mononuclear cells (PBMC) from patients with active bronchial asthma, while cellular IL-1alpha, IL-1beta production was reduced in patients with asthma in remission. IL-1alpha and IL-1beta production by PBMC (possibly reflecting airway inflammation) after exposure to Df antigen might be down-regulated in patients outgrowing mite antigen-induced asthma, because lipopolysaccharide-induced IL-1alpha, IL-1beta production (seen in both normal individuals and patients with active asthma) was also reduced when patients were in remission.
Noma
T
T
Department of Pediatrics, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Ichikawa
K
K
Yoshizawa
I
I
Aoki
K
K
Kawano
Y
Y
Baba
M
M
D000293:Adolescent; D000328:Adult; D000818:Animals; D039741:Antigens, Dermatophagoides; D001249:Asthma / Q000276:immunology* / Q000628:therapy; D002478:Cells, Cultured; D005260:Female; D006023:Glycoproteins / Q000276:immunology*; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D008925:Mites; D009000:Monocytes / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D012074:Remission Induction
D039741:Antigens, Dermatophagoides; D006023:Glycoproteins; D007375:Interleukin-1; D008070:Lipopolysaccharides