[Evaluation by MR imaging of neoadjuvant intra-arterial infusion chemotherapy in uterine cervical cancer].
Eight patients with uterine cervical cancer received two or three courses of neoadjuvant chemotherapy, including 254-S i.v. and CDDP i.a. Transcatheter arterial embolization (TAE) was added for seven patients. The therapeutic efficacy was evaluated by MR imaging and postoperative histopathological examination. Three patients achieved a complete response (CR) and five others were evaluated as a partial response (PR) on MR imaging. On postoperative histology, three of eight showed CR or PR, which coincided with MR findings. Viable cancer cells were shown in five patients. To detect these viable tumors, dynamic MR imaging was indispensable. However, because of limited spatial resolution, the detection of small residual tumors was not easy using dynamic MR imaging.
Yamano
T
T
Dept. of Radiology, Hyogo College of Medicine.
Takayasu
Y
Y
Inoue
J
J
Narasaki
K
K
Ando
K
K
Nakao
N
N
Adachi
S
S
Takemura
T
T
Kohyama
K
K
D000230:Adenocarcinoma / Q000628:therapy; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D018196:Carcinoma, Adenosquamous / Q000628:therapy; D002294:Carcinoma, Squamous Cell / Q000628:therapy; D002584:Cervix Uteri / Q000473:pathology*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D003287:Contrast Media; D004621:Embolization, Therapeutic; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007261:Infusions, Intra-Arterial; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D002583:Uterine Cervical Neoplasms / Q000628:therapy*
D000970:Antineoplastic Agents; D003287:Contrast Media; D019786:Gadolinium DTPA; D002945:Cisplatin