Idiopathic focal segmental glomerulosclerosis and HLA antigens.
The objective of the present study was to investigate a possible association between HLA class II antigens and idiopathic focal segmental glomerulosclerosis (FSGS). HLA-A, -B, -DR and -DQ antigens were determined in 19 Brazilian patients (16 white subjects and three subjects of Japanese origin) with biopsy-proven FSGS. Comparison of the HLA antigen frequencies between white patients and white local controls showed a significant increase in HLA-DR4 frequency among FSGS patients (37.7 vs 17.2%, P < 0.05). In addition, the three patients of Japanese extraction, not included in the statistical analysis, also presented HLA-DR4. In conclusion, our data confirm the association of FSGS with HLA-DR4 previously reported by others, thus providing further evidence for a role of genes of the HLA complex in the susceptibility to this disease.
Departamento de Pediatria, Escola Paulista de medicina, Universidade Federal de São Paulo, Brasil. ger.dped@epm.br
M
M
Gerbase-DeLima
A
A
Pereira-Santos
R
R
Sesso
J
J
Temin
E S
ES
Aragão
H
H
Ajzen
D001938:Brazil; D020022:Genetic Predisposition to Disease; D005923:Glomerulosclerosis, Focal Segmental / Q000235:genetics*; D006680:HLA Antigens / Q000235:genetics*; D015804:HLA-DR4 Antigen / Q000235:genetics; D006801:Humans; D044465:White People
D006680:HLA Antigens; D015804:HLA-DR4 Antigen