[The effect of an original analog of the C-terminal fragment of vasopressin on the behavior of white rats].
The influence was studied of a new analog of C-terminal fragment of argininvasopressin Ac-D-MPRG on locomotor and exploratory activity of rats. The peptide injected intranasally in the doses of 0.001, 0.01, 0.1, 1, and 10 mcg/kg one hour prior to testing did not affect the horizontal motor activity of the animals in the "open field" (with red light and white noise) and "Opto-Varimex" tests. It increased the vertical motor activity and decreased grooming in the "open field" and "hole board" tests. The results obtained demonstrate that the analog of AVP (6-9) fragment (with Cys6 changed for D-Met), as well as AVP, increases the exploratory activity. However, in contrast to the whole precursor molecule, the peptide does not change the level of nonspecific motor activity.
Lomonosov State University, Moscow.
N S
NS
Ponomareva
O G
OG
Voskresenskaia
A A
AA
Kamenskiĭ
V P
VP
Golubovich
I P
IP
Ashmarin
D000281:Administration, Intranasal; D000818:Animals; D001127:Arginine Vasopressin / Q000008:administration & dosage / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004644:Emotions / Q000187:drug effects / Q000502:physiology; D005106:Exploratory Behavior / Q000187:drug effects / Q000502:physiology; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship
D010446:Peptide Fragments; C112795:acetylmethionyl-prolyl-arginyl-glycinamide; D001127:Arginine Vasopressin