Pineal peptide preparation epithalamin increases the lifespan of fruit flies, mice and rats.
Treatment with pineal peptide preparation epithalamin was followed by the increase of the mean lifespan of female D. melanogaster, SHR mice, C3H/Sn mice and LIO rats by 11-31% (P < 0.05). Ninety percent mortality as well as maximum lifespan were increased in fruit flies, C3H/Sn mice and rats. Mortality rate was decreased by 52% in D. melanogaster, by 52% in rats, by 27% in C3H/Sn mice. It did not change in SHR mice exposed to epithalamin. Treatment with the pineal peptide increased MRDT in flies, C3H/Sn mice and rats. It has been shown that epithalamin increased synthesis and secretion of melatonin in rats and inhibits free radical processes in rats and in D. melanogaster. It is suggested that antioxidative properties of epithalamin lead to increased lifespan of three different animal species.
Laboratory of Experimental Tumors, N.N. Petrov Research Institute of Oncology, St. Petersburg, Russia.
V N
VN
Anisimov
S V
SV
Mylnikov
V K
VK
Khavinson
D000818:Animals; D004331:Drosophila melanogaster / Q000187:drug effects*; D005260:Female; D008136:Longevity / Q000187:drug effects*; D051379:Mice / Q000502:physiology*; D008809:Mice, Inbred C3H; D010455:Peptides / Q000494:pharmacology*; D010870:Pineal Gland / Q000502:physiology*; D051381:Rats / Q000502:physiology*
D010455:Peptides; C027437:epithalamin