Newborn tissue concentrations of bupivacaine following maternal epidural administration during labor in guinea pigs.
Newborn plasma concentrations of maternally administered bupivacaine are often measured, but it is unclear how well they reflect tissue concentrations. Bupivacaine (0.25%) was administered epidurally (0. 12 ml/kg) 10 min prior to labor induction in 6 term-pregnant guinea pigs. Plasma, brain, heart and liver samples were obtained for bupivacaine analysis from newborns (n = 22) after spontaneous delivery. Liver bupivacaine concentrations were 2-3 times greater than those in the plasma, brain, and heart. A similar pattern of tissue concentrations was seen in a smaller number of newborns delivered by cesarean section. Liver bupivacaine concentration decreased with drug-delivery interval in littermates, while heart and brain concentrations showed no relationship with drug-delivery interval. Blood gases of newborns reflected acidosis, which may have influenced tissue drug concentrations. Under conditions of the study, bupivacaine concentrations in heart and brain, potential sites of bupivacaine action, were lower than those observed in a peripheral blood sample.
Golub
M S
MS
California Regional Primate Research Center, School of Veterinary Medicine, University of California, Davis, Calif., USA.
Kaaekuahiwi
M A
MA
Eisele
P H
PH
Zhang
H
H
Jones
A D
AD
Eisele
J H
JH
D000779:Anesthetics, Local; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001923:Brain Chemistry; D002045:Bupivacaine / Q000008:administration & dosage* / Q000032:analysis* / Q000493:pharmacokinetics; D002245:Carbon Dioxide / Q000008:administration & dosage; D002585:Cesarean Section; D036861:Delivery, Obstetric; D005260:Female; D005333:Fetus / Q000378:metabolism; D006168:Guinea Pigs; D007268:Injections, Epidural; D007743:Labor, Obstetric; D008099:Liver / Q000737:chemistry; D009206:Myocardium / Q000737:chemistry; D011247:Pregnancy
D000779:Anesthetics, Local; D002245:Carbon Dioxide; D002045:Bupivacaine