Studies on segmented polyetherurethane for biomedical application: effects of composition and hard-segment content on biocompatibility.
Segmented polyetherurethane (SPEU) materials based on polytetramethylene oxide (PTMO, Mw 1000 and 2000) with various hard-segment contents were synthesized and their biocompatibilities studied via different tests. The static contact angle data reveal that the higher hard-segment-content SPEU material possesses a lower contact angle, implying that the surface of the higher hard-segment-content SPEU is more hydrophilic than its low hard-segment-content SPEU counterpart. The catalyst- and additive-free PTMO-based SPEU materials in this study possess neither a hemolytic nor a cytotoxic response that could be considered non toxic for biomedical applications. By using L-929 cell lines, a cell-seeding test indicated that the higher hard-segment-content SPEU material possesses quicker cell attachment and proliferation behaviors. In vitro platelet adhesion tests indicated that the lower hard-segment-content SPEU possesses less platelet adhesion than the high hard-segment-content SPEU material. Both ex vivo canine artery-artery (A-A) and arterio-venous (A-V) shunting tests revealed that the extent of platelet adhesion reaction is less for lower hard-segment content SPEU. In addition, the blood compatibility of SPEU material synthesized from PTMO 1000 excels over PTMO 2000 SPEU material by near the same levels as the hard-segment-content SPEU.
Chen
J H
JH
Union Chemical Laboratories (UCL), Industrial Technology Research Institute (ITRI), Hsinchu, Taiwan, Republic of China.
Wei
J
J
Chang
C Y
CY
Laiw
R F
RF
Lee
Y D
YD
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001792:Blood Platelets / Q000166:cytology; D002448:Cell Adhesion; D002460:Cell Line; D002470:Cell Survival; D004285:Dogs; D051379:Mice; D011140:Polyurethanes / Q000737:chemistry
D001672:Biocompatible Materials; D011140:Polyurethanes; C115016:polyetherurethane