Promyelocytic blast crisis of chronic myelogenous leukaemia with translocations (9;22) and (15;17).
The promyelocytic blast crisis is a rare form of transformation during the evolution of chronic myeloid leukaemia (CML). We report a case of promyelocytic blast crisis with t(15;17) in addition to t(9;22). The morphology and immunophenotype of the blasts were similar to those seen in acute promyelocytic leukaemia (APL). The t(15;17) was confirmed by FISH. The patient had evidence of coagulopathy with clinical and laboratory findings of disseminated intravascular coagulation (DIC). This report highlights the importance of correlating the results of multiple diagnostic methods in order to establish a correct diagnosis of the promyelocytic blast crisis of CML.
Scolnik
M P
MP
Immunología Oncológica, Academia Nacional de Medicina, Buenos Aires, Argentina.
Palacios
M F
MF
Acevedo
S H
SH
Castuma
M V
MV
Larripa
I B
IB
Palumbo
A
A
Moiraghi
E B
EB
Sasot
A M
AM
Huberman
A B
AB
D001752:Blast Crisis; D002884:Chromosomes, Human, Pair 15; D002886:Chromosomes, Human, Pair 17; D002892:Chromosomes, Human, Pair 22; D002899:Chromosomes, Human, Pair 9; D006801:Humans; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics / Q000473:pathology*; D015473:Leukemia, Promyelocytic, Acute / Q000235:genetics / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic