Cloning and tissue expression of two putative steroid membrane receptors.
We have cloned two human putative steroid binding membrane proteins, termed Hpr6.6 and Dg6. Hpr6.6 is the human homolog of a previously cloned porcine progesterone binding protein. Both proteins contain a putative transmembrane domain and a highly conserved stretch of 58 amino acids. Hpr6.6 mRNA is expressed predominantly in liver and kidney, whereas Dg6 mRNA is preferentially expressed in placenta. Hpr6.6 is located on the X chromosome and dg6 on chromosome 4. The two proteins are the first putative steroid membrane receptors cloned from man.
Institute of Clinical Pharmacology, Faculty of Clinical Medicine at Mannheim, University of Heidelberg, Germany.
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Gerdes
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Wehling
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Leube
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Falkenstein
D000595:Amino Acid Sequence; D001483:Base Sequence; D002460:Cell Line; D003001:Cloning, Molecular; D018076:DNA, Complementary; D006801:Humans; D008565:Membrane Proteins / Q000096:biosynthesis / Q000235:genetics*; D008969:Molecular Sequence Data; D011980:Receptors, Progesterone; D011987:Receptors, Steroid / Q000096:biosynthesis / Q000235:genetics*; D014018:Tissue Distribution
D018076:DNA, Complementary; D008565:Membrane Proteins; C115296:PGRMC1 protein, human; C115297:PGRMC2 protein, human; D011980:Receptors, Progesterone; D011987:Receptors, Steroid