[Pre-leukemic granulocytic sarcoma of the uterus. Report of a case].
A case of pre-leukemic granulocytic sarcoma (GS) of the uterus was found in a 73-year old woman. The diagnosis was suggested by vaginal cytology and the green color of the gross lesions, then confirmed by naphthol AS-D chloro acetate esterase stain and immunohistochemistry on fixed tissue with the anti-lysozyme, anti-myeloperoxidase, CD 43 and CD15 antibodies. At the time of GS discovery, the patient presented no evident leukemia but myelogram contained 20% of blast cells. She developed acute myeloid leukemia 2 months later. Cytogenetic study of the bone marrow revealed chromosome 21 trisomy. GS is frequently mistaken for malignant lymphoma since it expresses some of the leukocytic antigens (leukocyte common antigen, CD 45 RO (UCHL1), MB2). Therefore, the use of a large panel of antibodies, including anti-myeloperoxidase, anti-lysozyme and CD15, is recommended. Precise diagnosis is essential because all GS must be treated as acute myeloid leukemias.
Service d'Anatomie et de Cytologie Pathologiques, Institut Gustave Roussy, Villejuif.
C
C
Glaser
B
B
Michelon
J Y
JY
Peltier
C
C
Duboucher
A
A
Bernheim
G
G
Périé
D000208:Acute Disease; D000368:Aged; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007951:Leukemia, Myeloid / Q000175:diagnosis*; D011230:Precancerous Conditions / Q000175:diagnosis*; D014594:Uterine Neoplasms / Q000175:diagnosis*