Control of cell proliferation by Myc.
Myc proteins are key regulators of mammalian cell proliferation. They are transcription factors that activate genes as part of a heterodimeric complex with the protein Max. This review summarizes recent progress in understanding how Myc stimulates cell proliferation and how this might contribute to cellular transformation and tumorigenesis.
Institute for Molecular Biology and Tumour Research, University of Marburg, Germany. bouchard@imt.uni-marburg.de
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D000818:Animals; D002455:Cell Division / Q000187:drug effects; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D016271:Proto-Oncogene Proteins c-myc / Q000502:physiology*; D014158:Transcription, Genetic / Q000187:drug effects
D006133:Growth Substances; D016271:Proto-Oncogene Proteins c-myc