Physicochemical environment of the colon.
Epidemiological evidence suggests that 80-90% of colorectal cancer is caused by dietary and environmental factors and that the prevalence of cancer can be altered in low-risk patients by long-term alterations in dietary fibre ingestion. It has therefore become increasingly important to examine the available data on colonic pH and transit, and on faecal short-chain fatty acids in different groups, in order to establish the relationship between fibre intake, colonic acidification and the predisposition to cancer in different ethnic groups.
St Bartholomew's, London, UK.
D F
DF
Evans
D000818:Animals; D003106:Colon / Q000737:chemistry / Q000502:physiology*; D015179:Colorectal Neoplasms / Q000453:epidemiology; D004043:Dietary Fiber; D004063:Digestion; D005232:Fatty Acids, Volatile; D005772:Gastrointestinal Transit; D006801:Humans; D006863:Hydrogen-Ion Concentration
D004043:Dietary Fiber; D005232:Fatty Acids, Volatile