[The pre- and postsynaptic mechanisms of the involvement of the serotonin of the amygdaloid body in the reproduction of the conditioned passive avoidance reaction in rats].
Serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) content, MAO activity, and [3H]-5-HT specific binding were examined in rat amygdala at different stages of one-trial passive avoidance training. Serotonergic changes were revealed only at the stage of the avoidance recall. The [3H]-5-HT specific binding was decreased, MAO activity was increased and accompanied by enhanced 5-HIAA transport from serotonergic terminals. No changes were revealed in 5-HT content. It is suggested that the retrieval processes in passive avoidance learning are mediated by serotonergic system of the amygdala.
Institute of Physiology, Russian Academy of Medical Sciences, Siberian Branch, Novosibirsk.
G F
GF
Molodtsova
R Iu
RIu
Il'iuchenok
D000679:Amygdala / Q000502:physiology*; D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D001923:Brain Chemistry / Q000502:physiology; D003214:Conditioning, Classical / Q000502:physiology*; D008297:Male; D008568:Memory / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D017661:Receptors, Presynaptic / Q000502:physiology*; D011985:Receptors, Serotonin / Q000502:physiology*; D012054:Reinforcement, Psychology; D012701:Serotonin / Q000502:physiology*; D013569:Synapses / Q000502:physiology*
D017661:Receptors, Presynaptic; D011985:Receptors, Serotonin; D012701:Serotonin