Peptide and peptidomimetic libraries. Molecular diversity and drug design.
Various techniques for generation of peptide and peptidomimetic libraries are summarized in this article. Multipin, tea bag, and split-couple-mix techniques represent the major methods used to make peptides and peptidomimetics libraries. The synthesis of these libraries were made in either discrete or mixture format. Peptides and peptidomimetics combinatorial libraries were screened to discover leads against a variety of targets. These targets, including bacteria, fungus, virus, receptors, and enzymes were used in the screening of the libraries. Discovered leads can be further optimized by combinatorial approaches.
al-Obeidi
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Selectide Research Center, a Subsidiary of Hoechst-Marion-Roussel, Tucson, AZ, USA. Fahad.Al-Obeidi@hmrag.com
Hruby
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VJ
Sawyer
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TK
D000595:Amino Acid Sequence; D006801:Humans; D018716:Molecular Mimicry; D008969:Molecular Sequence Data; D019151:Peptide Library; D010455:Peptides
D019151:Peptide Library; D010455:Peptides