Hepatic outflow obstruction and liver failure due to leukemic cell infiltration in chronic lymphocytic leukemia.
We report a patient with advanced progressive CLL who presented with liver failure and hepatic venus outflow obstruction (HVOD) due to lymphocytic leukemic infiltrates. Initiation of antileukemic therapy resulted in a rapid and prompt resolution of these life-threatening complications. This is apparently the first report of a CLL patient with HVOD and liver failure, attributable to liver infiltration by leukemic cells.
Division of Hematological/Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
F
F
Costa
C G
CG
Choy
K
K
Seiter
L
L
Hann
S N
SN
Thung
J
J
Michaeli
D006504:Hepatic Veno-Occlusive Disease / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D017254:Leukemic Infiltration; D008099:Liver / Q000473:pathology*; D017093:Liver Failure / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged