Absorbability of sulphamonomethoxine and sulphadimethoxine administered via food of laying hens.
Sulphamonomethoxine (SMM) or sulphadimethoxine (SDM) were fed each to four laying hens at a dietary content of 400 p.p.m. 1000 p.p.m. of chromic oxide were supplemented to the experimental diets as an indicator for the absorbability in the gastrointestinal tract. SMM and SDM contents (p.p.m.) in the large intestine, determined 16 h after the start of feeding, were measured by HPLC. Average amounts of SMM and SDM in the dry matter of the large intestine were 12.3 and 30.2 p.p.m., respectively. The absorption ratios of SMM and SDM administered via the food were calculated to be 96.9 and 92.5%, respectively.
Faculty of Human Life Science, Osaka City University, Japan.
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Furusawa
D000284:Administration, Oral; D000821:Animal Feed; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002645:Chickens / Q000378:metabolism*; D005260:Female; D007408:Intestinal Absorption; D013412:Sulfadimethoxine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013422:Sulfamonomethoxine / Q000008:administration & dosage / Q000493:pharmacokinetics*
D000890:Anti-Infective Agents; D013412:Sulfadimethoxine; D013422:Sulfamonomethoxine