[The effect of anesthesia on kidney scintigraphy in the dog].
Renal scintigraphy is one of the diagnostic devices in the upper urinary tract. In 24 dogs of different age, sex and breed that--according to the usual laboratory tests--were considered healthy with respect to renal function, a renal scintigraphy with the tubular excreted tracer 99mTc-MAG3 was performed. The dogs were grouped according to three different anaesthetic regimens in order to estimate the influence of anaesthesia--which is necessary for this investigation--onto function of the normal kidney. Eight dogs were scintigraphed twice using different anaesthesia protocols. In group A (n = 22), anaesthesia was performed with a combination of atropine/diazepam/ketamine/xylazine. The reference range determined was for the period of maximal activity accumulation (Tmax) 3.2 +/- 0.8 min and for the elimination half-time (Tmax/2) 6.3 +/- 1.4 min. MAG3-clearance was 7.5 +/- 1.8 ml/min/kg. Group B (n = 5) received thiopental as a continuous intravenous infusion. Tmax was measured with 2.9 +/- 1.1 min, Tmax/2 with 4.7 +/- 1.2 min and the MAG3-clearance was 6.8 +/- 1.6 ml/min/kg. In group C (n = 5), the dogs were given propofol and halothane, and the values determined for Tmax and Tmax/2 were 4.8 +/- 2.7 and 4.8 +/- 1.4 min, respectively. The MAG3-clearance was 10.0 +/- 2.3 ml/min/kg. It is concluded that the anaesthetic regime used has a distinct influence on the reference values.
Klinik für kleine Haustiere, Tierärztlichen Hochschule Hannover.
C
C
Rückert
A
A
Meyer-Lindenberg
I
I
Nolte
D000758:Anesthesia / Q000009:adverse effects / Q000662:veterinary*; D000777:Anesthetics / Q000008:administration & dosage / Q000494:pharmacology*; D019162:Anesthetics, Combined / Q000008:administration & dosage; D000818:Animals; D001285:Atropine / Q000008:administration & dosage / Q000494:pharmacology; D003975:Diazepam / Q000008:administration & dosage / Q000494:pharmacology; D004285:Dogs / Q000502:physiology*; D005260:Female; D006207:Half-Life; D006221:Halothane / Q000008:administration & dosage / Q000494:pharmacology; D007262:Infusions, Intravenous / Q000662:veterinary; D007649:Ketamine / Q000008:administration & dosage / Q000494:pharmacology; D007668:Kidney / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000502:physiology; D008297:Male; D015742:Propofol / Q000008:administration & dosage / Q000494:pharmacology; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012016:Reference Values; D017263:Technetium Tc 99m Mertiatide; D013874:Thiopental / Q000008:administration & dosage / Q000494:pharmacology; D014991:Xylazine / Q000008:administration & dosage / Q000494:pharmacology
D000777:Anesthetics; D019162:Anesthetics, Combined; D019275:Radiopharmaceuticals; D014991:Xylazine; D017263:Technetium Tc 99m Mertiatide; D007649:Ketamine; D001285:Atropine; D013874:Thiopental; D003975:Diazepam; D006221:Halothane; D015742:Propofol