[Comparison of hypercholesterolemic men and women at high risk for atherosclerosis. Study of risk factors and response to pravastatin treatment].
OBJECTIVE
To compare the prevalence of risk factors, and the response to pravastatin treatment between men and women.


METHODS
We evaluated 486 men and 386 women, of these 230 men and 187 women received 10 mg of pravastatin for three months.


RESULTS
There were differences between women and men in respectively: arterial hypertension (45.5% vs 40.8%; p = 0.0012), left ventricular hypertrophy (33.0% vs 22.0%; p = 0.0041), sedentarism (94.8% vs 87.8%; p = 0.0005), smoking (43.0% vs 61.8%; p < 0.0001), Framingham scores (20.0 +/- 7.1 vs 16.0 +/- 7.6 p < 0.0001), HDL-C (43.0 +/- 11.0 vs 38.0 +/- 9.0 mg/dL; p 0.001), triglycerides-TG (216.0 +/- 115.0 vs 271.0 +/- 172.0 mg/dL; p < 0.001) and Castelli's indexes (CI) I and II (7.7 +/- 2.6 vs 8.6 +/- 3.2; p = 0.002 and 5.0 +/- 1.5 vs 5.5 +/- 2.0; p = 0.015). In men under pravastatin treatment there was a greater reduction in TG (32.0 vs 21.0% p < 0.05) and CI I (-41.0% vs -37.0%; p < 0.05) and II (-40.0% vs -38.0%; p < 0.05).


CONCLUSIONS
Men and women differed in risk factors prevalence and response to treatment with pravastatin.
Instituto do Coração, Hospital das Clínicas, FMUSP.
R D
RD
Santos
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Maranhão
D000328:Adult; D000368:Aged; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D001161:Arteriosclerosis / Q000209:etiology; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D017035:Pravastatin / Q000627:therapeutic use*; D012307:Risk Factors; D012737:Sex Factors
D000924:Anticholesteremic Agents; D017035:Pravastatin