White matter changes and poststroke dementia.
Stroke patients are more likely to have white matter changes than age- and sex-matched controls. White matter changes are associated with an increased risk of dementia occurring after stroke: they often indicate a higher risk of stroke recurrence and they may lead to slight cognitive impairment. Besides white matter changes, vascular lesions of the brain and associated Alzheimer pathology, the summation of 2 or 3 of these mechanisms may lead to dementia in stroke patients even when each type of lesion is not severe enough to induce dementia by its own.
Department pf Neurology, University of Lille, France. dleys@chru-lille.fr
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D
Leys
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Hénon
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Pasquier
D001921:Brain / Q000473:pathology*; D002561:Cerebrovascular Disorders / Q000150:complications* / Q000473:pathology*; D003704:Dementia / Q000209:etiology* / Q000473:pathology*; D006801:Humans