Is the medial globus pallidus a site for stimulation or lesioning in the treatment of Parkinson's disease?
After the encouraging report on bilateral pallidal stimulation by Siegfried in 1994, we started this procedure in 1995 and will report our experience in 6 patients with a mean follow-up of 1 year. In contrast to the good results of pallidotomy reported in the literature improving the 'on' symptoms as dyskinesias as well as 'off' symptoms such as rigidity, bradykinesia and on-off fluctuations, our results indicate that pallidal stimulation improves the 'off' symptoms only to a minor extent and L-dopa-induced dyskinesias remain the main indication. Considering the overall functional outcome, the question arises whether the medial globus pallidus should be lesioned or stimulated.
Department of Neurological Surgery, University Hospital, Heidelberg College of Medicine, Germany. vtronnier@krzmail.krz.uni-heidelberg.de
V M
VM
Tronnier
W
W
Fogel
M
M
Kronenbuerger
M
M
Krause
S
S
Steinvorth
D000368:Aged; D004599:Electric Stimulation Therapy; D004567:Electrodes, Implanted; D005500:Follow-Up Studies; D007839:Functional Laterality / Q000502:physiology; D005917:Globus Pallidus / Q000033:anatomy & histology / Q000502:physiology* / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008839:Microelectrodes; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D010300:Parkinson Disease / Q000601:surgery* / Q000628:therapy*; D013238:Stereotaxic Techniques; D016896:Treatment Outcome