RTI-113 administration reduces cocaine self-administration at high occupancy of dopamine transporter.
RTI-113 [3beta-(4-chlorophenyl)tropan-2beta carboxylic acid phenyl ester hydrochloride], one of many phenyltropanes potent at and selective for DAT, inhibited self-administration of cocaine in rat at doses that did not alter responding maintained by food. The doses that inhibited cocaine intake produced significant levels of occupancy of DAT.
Bowman Gray School of Medicine, Winston Salem, North Carolina 27103, USA.
S I
SI
Dworkin
P
P
Lambert
G M
GM
Sizemore
F I
FI
Carroll
M J
MJ
Kuhar
D000818:Animals; D003042:Cocaine / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005108:Extinction, Psychological; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D012054:Reinforcement, Psychology; D012646:Self Administration; D019966:Substance-Related Disorders / Q000517:prevention & control*
C114870:RTI-113; D003042:Cocaine