4-Hydroxybenzoic acid: a hypoglycemic constituent of aqueous extract of Pandanus odorus root.
Hypoglycemic activity-guided fraction led to the isolation of the known compound, 4-hydroxybenzoic acid, from Pandanus odorus Ridl. (Thai name: Toei-hom, Pandanaceae). This compound showed a hypoglycemic effect in normal rats after the oral administration of 5 mg/kg. Additionally, the compound increased serum insulin levels and liver glycogen content in normal rats.
Peungvicha
P
P
Faculty of Pharmacy, Mahidol University, Bangkok, Thailand. pyppv@mahidol.ac.th
Temsiririrkkul
R
R
Prasain
J K
JK
Tezuka
Y
Y
Kadota
S
S
Thirawarapan
S S
SS
Watanabe
H
H
D000818:Animals; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D008112:Liver Glycogen / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010226:Parabens / Q000737:chemistry / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
D007004:Hypoglycemic Agents; D007328:Insulin; D008112:Liver Glycogen; D010226:Parabens; D010936:Plant Extracts; C038193:4-hydroxybenzoic acid