Antibody responses in humans against coli surface antigen 6 of enterotoxigenic Escherichia coli.
Enterotoxigenic Escherichia coli (ETEC) strains expressing only coli surface antigen 6 (CS6) have previously been isolated from patients with diarrhea, but the immunogenicity of CS6 has not been established in humans. We have detected CS6-specific immunoglobulin A responses in the feces and blood of patients convalescing from natural ETEC disease and of volunteers given an oral ETEC vaccine.
Department of Medical Microbiology and Immunology, Göteborg University, Göteborg, Sweden. anna.helander@microbio.gu.se
A
A
Helander
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C
Wennerås
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F
Qadri
A M
AM
Svennerholm
D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis*; D000942:Antigens, Bacterial / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology*; D001426:Bacterial Proteins / Q000276:immunology*; D003967:Diarrhea / Q000276:immunology / Q000382:microbiology; D004797:Enzyme-Linked Immunosorbent Assay; D004926:Escherichia coli / Q000276:immunology*; D004927:Escherichia coli Infections / Q000276:immunology; D029968:Escherichia coli Proteins; D006801:Humans; D015151:Immunoblotting; D007070:Immunoglobulin A / Q000032:analysis*
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D000954:Antigens, Surface; D001426:Bacterial Proteins; C098406:CS6 antigen, E coli; D029968:Escherichia coli Proteins; D007070:Immunoglobulin A