Lipophilin, a novel heterodimeric protein of human tears.
We identified a novel heterodimeric protein, lipophilin AC, in human tears. One of its components, lipophilin A (69 residues; mass, 7575.1; pI, 9.47) was homologous to the C1 and C2 components of prostatein ('estramustine-binding protein'), the major secreted protein of rat prostate. Human lipophilin C (77 residues; mass, 8854.1; pI, 4.94) was homologous to the rat prostatein C3 component and to human mammaglobin, a protein overexpressed in some mammary carcinomas. Tear lipophilins A and C expand the roster of human uteroglobin superfamily members and provide models for exploring these typically steroid-regulated and steroid-binding molecules.
Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095, USA. rlehrer@med1.medsch.ucla.edu
R I
RI
Lehrer
G
G
Xu
A
A
Abduragimov
N N
NN
Dinh
X D
XD
Qu
D
D
Martin
B J
BJ
Glasgow
D000595:Amino Acid Sequence; D002851:Chromatography, High Pressure Liquid; D019281:Dimerization; D006801:Humans; D060788:Mammaglobin B; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009185:Myelin Proteins / Q000032:analysis / Q000737:chemistry* / Q000302:isolation & purification; D010455:Peptides / Q000737:chemistry / Q000378:metabolism; D011485:Protein Binding; D011487:Protein Conformation; D011510:Proteolipids / Q000032:analysis / Q000737:chemistry* / Q000302:isolation & purification; D060765:Secretoglobins; D017421:Sequence Analysis; D017386:Sequence Homology, Amino Acid; D013666:Tears / Q000737:chemistry*; D014598:Uteroglobin
D060788:Mammaglobin B; D009185:Myelin Proteins; D010455:Peptides; D011510:Proteolipids; C556463:SCGB1D1 protein, human; C556467:SCGB2A1 protein, human; D060765:Secretoglobins; D014598:Uteroglobin