[Effective renal plasma flow with I-131-hipuran: evaluation of a method with four extractions].
The aim of this work was to evaluate a method for the estimation of the effective renal plasma flow (ERPF) using sodium 131I-o-hippurate (OIH) by means the bicompartmental analysis of the radioactive concentration of 4 plasma samples, analyzing the error obtained respecting to the multi-sample method and comparing it with those obtained with other simplified methods. We calculated the ERPF from 62 patients using the multi-sample method as standard, the method based in a single sample at 44 minutes p.i., a method based in 2 samples from the first exponential, 4 methods based in 2 samples from the second exponential, one method based in 3 samples and 5 methods based in 4 samples (2 from the first exponential and 2 from the second exponential). Each simplified method was compared to the standard method and their absolute error (AE) and standard estimation error (SEE) were calculated. The method based in the 4 samples withdrawn at 4, 10, 30 and 60 minutes p.i. was the best of them with a correlation factor with the standard equal to 0.997, an EA that ranged from -63 ml/min to 49 ml/min (mean: -4 ml/min) and a SEE of 19.5 ml/min.
Servicio de Medicina Nuclear, Ciutat Sanitària i Universitària de Bellvitge, L'Hospitalet de Llobregat, Barcelona, 08907, España.
M
M
Roca
R
R
Puchal
V
V
García
F
F
Iglesias
V
V
Gomes
J
J
Mora
V
V
Vallejos
M
M
Castell
A
A
Fernández
D001825:Body Fluid Compartments; D005260:Female; D006801:Humans; D007465:Iodohippuric Acid / Q000493:pharmacokinetics; D007677:Kidney Function Tests / Q000379:methods*; D008297:Male; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D012079:Renal Circulation; D015203:Reproducibility of Results
D007465:Iodohippuric Acid