[Clinical evaluation of intraoperative radiotherapy using photon radiosurgery system for brain tumors].
The photon radiosurgery system is a miniature X-ray generator that can be placed stereotactically and intraoperatively into intracranial tumors to deliver a single fraction of high-dose interstitial irradiation. This battery-powered device produces low energy X-ray photons in a spherical and symmetrical pattern at the probe tip. Dose rates of up to 200 cGy/Mim are possible, allowing for the administration of 15 Gy to a lesion 3 cm in diameter in less than 1 hr. Background exposure is minimal, and no special shielding of the patient or health care personnel is required. Thirty-nine patients with brain tumor were treated in this method. There were no adverse effects. During the follow-up period of 1-30 months, 3 cases with 5 metastatic brain tumors died about 8 months after this treatment. Five recurrent cases of 21 malignant gliomas died about 4 months after treatment. Interstitial radiotherapy using photon the radiosurgery system promises to be a useful treatment for brain tumors.
Kubo
O
O
Dept. of Neurosurgery, Tokyo Women's Medical College.
Muragaki
Y
Y
Iseki
H
H
Takakura
K
K
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000188:drug therapy / Q000601:surgery*; D002648:Child; D003131:Combined Modality Therapy; D006801:Humans; D015376:Nimustine / Q000008:administration & dosage; D016634:Radiosurgery / Q000295:instrumentation; D013238:Stereotaxic Techniques; D014750:Vincristine / Q000008:administration & dosage
D015376:Nimustine; D014750:Vincristine