[Effect of GABA and piracetam on on ATPase activity in brain and liver mitochondria in experimental hypokinesis].
Long-term hypokinesia is accompanied by changes in the activity of Mg(2+) and 2,4-dinitrophenol (DNP)-stimulated ATPases of rat brain and liver mitochondria. These changes are phasic and especially pronounced at periods characterised by most pronounced metabolic alterations Treatment of animals with GABA and piracetam tends to normalise the enzyme activities.
Akopian
V P
VP
Department of Pharmacology, Yerevan State Medical University, Armenia.
Sotskiĭ
O P
OP
Mailian
K R
KR
Edigarova
L V
LV
Shafrazian
D S
DS
Vasilian
A A
AA
D019297:2,4-Dinitrophenol / Q000494:pharmacology; D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004789:Enzyme Activation; D018476:Hypokinesia / Q000201:enzymology*; D008274:Magnesium / Q000378:metabolism; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D010889:Piracetam / Q000494:pharmacology*; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D005680:gamma-Aminobutyric Acid; D000251:Adenosine Triphosphatases; D008274:Magnesium; D019297:2,4-Dinitrophenol; D010889:Piracetam