Let not thy left hand know what thy right hand knoweth. The case of a patient with an infarct involving the callosal pathways.
Following a cerebral vascular accident, a patient showed a classical disconnection syndrome: left-hand tactile anomia, apraxia and dysgraphia and right-hand constructional apraxia. What made the case unusual was the presence of hand asymmetry in the performance of some matching-to-sample tasks carried out in foveal vision. The left hand committed significantly more errors than the right hand when it was not possible to identify on a perceptual basis the stimulus that was to be matched, because it was removed (memory condition) or was indicated verbally (verbo-visual matching), or had the same name but not the same physical appearance as the match (capital and lower-case letter matching). No hand difference emerged when the stimulus remained in full view throughout the matching task (perceptual condition). The hand effect, however, was limited to colours and letters. Objects, geometrical shapes and unfamiliar faces were matched with equal proficiency by both hands under every condition of presentation. Left-hand errors also significantly outnumbered right-hand errors in sorting colours according to hue and colouring drawings. MRI showed an infarct in the left cingulate white matter that ran parallel to the trunk of the corpus callosum, and an infarct of the splenium. However, the latter did not prevent the transmission of colour and letter information between the two hemispheres, as shown by the performance on perceptual equivalence tasks and by the correct right-hand responses to stimuli projected to the left visual field. We propose that this pattern of deficit is contingent upon the specific role that the left hemisphere plays in categorizing a given colour patch as belonging to a definite colour region (red, blue, etc.) and in grapheme recognition. Without the assistance of the left side the right hemisphere lacks the benefit provided by meaning identification. In our patient the left brain did receive information from the right brain and was able to process it, but was prevented by the paracallosal lesion from transmitting what it knew to the right motor area. No hand effect emerged for objects and geometrical shapes, because their semantic memory is bilaterally represented.
Centro Ricerche di Neuropsicologia, IRCCS S. Lucia, Rome, Italy.
P
P
Marangolo
E
E
De Renzi
E
E
Di Pace
P
P
Ciurli
A
A
Castriota-Skandenberg
D000368:Aged; D000369:Aged, 80 and over; D001244:Association; D002544:Cerebral Infarction / Q000503:physiopathology* / Q000523:psychology*; D003116:Color; D003337:Corpus Callosum / Q000098:blood supply*; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007807:Language Tests; D008297:Male; D008568:Memory / Q000502:physiology; D009483:Neuropsychological Tests; D010775:Photic Stimulation; D011930:Reaction Time / Q000502:physiology; D014796:Visual Perception / Q000502:physiology