Fetal thyrotrophin: the best indicator of long term thyroid function after in utero exposure to iodine-131?
A woman treated with radioiodine for thyrotoxicosis was subsequently found to be 19 weeks pregnant at the time of treatment. Fetal thyroid hormone levels in utero were normal or mildly elevated but fetal thyrotrophin (TSH) levels were very high. The baby remained euthyroid after birth, but required treatment with thyroid hormone replacement to normalise the TSH level. Neurodevelopment was normal at age 36 months.
Fetal Medicine and Surgery Unit, Arrowe Park Hospital, Wirral, Liverpool, UK.
C R
CR
Welch
M
M
Hocking
J A
JA
Franklyn
M J
MJ
Whittle
D000328:Adult; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006111:Graves Disease / Q000188:drug therapy; D006801:Humans; D007231:Infant, Newborn; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy; D013971:Thyrotoxicosis / Q000188:drug therapy; D013972:Thyrotropin / Q000097:blood*
D007457:Iodine Radioisotopes; D013972:Thyrotropin