Enteral administration of lipid emulsions protects liver cytochrome c oxidase from hepatotoxic action of thioacetamide.
During 48 hours after application sublethal doses of hepatotoxic agent thiacetamide decrease cytochrome c oxidase activity of rat liver homogenate and isolated mitochondria to 46% and 32% of original values, respectively. This decrease may be prevented by simultaneous application of lipid emulsion (mixture of Lipofundin and Mygliol) twice b day.
Department of Physiology, Faculty of Medicine, Charles University, Hradec Králové, Czech Republic.
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Cervinková
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Drahota
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D003576:Electron Transport Complex IV / Q000378:metabolism*; D004655:Emulsions / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D008055:Lipids / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology; D051381:Rats; D017208:Rats, Wistar; D013853:Thioacetamide / Q000633:toxicity*
D004655:Emulsions; D004791:Enzyme Inhibitors; D008055:Lipids; D013853:Thioacetamide; D003576:Electron Transport Complex IV; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase