Xenoestrogens significantly enhance risk for breast cancer during growth and adolescence.
Breast cancer is one of the most common forms of cancer observed in women, and endogenous estrogen is thought to play a major role in its development. Because of this, any conditions or exposures which enhance estrogenic responses would result in an increased risk for breast cancer. The role of xenoestrogenic compounds, such as DDT, in the etiology of breast cancer is still very controversial. In the following paper we discuss recently-published observations by ourselves and others which indicate that xenoestrogens may play a significant role in the development of breast cancer. Specifically, we hypothesize that during periods of high growth rates and during breast development the sensitivity of breast cells to estrogenic compounds is sufficiently great for xenoestrogens to significantly enhance risk for breast cancer.
Department of Biological and Exercise Sciences, Northeastern Illinois University, Chicago 60625-4699, USA. cmardies@aol.com
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D001943:Breast Neoplasms / Q000453:epidemiology / Q000209:etiology*; D003634:DDT / Q000009:adverse effects; D004968:Estrogens, Non-Steroidal / Q000009:adverse effects* / Q000378:metabolism; D005260:Female; D005505:Food Coloring Agents / Q000009:adverse effects; D006801:Humans; D015994:Incidence; D008954:Models, Biological; D018716:Molecular Mimicry; D011960:Receptors, Estrogen / Q000378:metabolism; D012307:Risk Factors; D014481:United States
D004968:Estrogens, Non-Steroidal; D005505:Food Coloring Agents; D011960:Receptors, Estrogen; D003634:DDT