Use of the Malthus-AT system to assess the efficacy of permeabilizing agents on the activity of antibacterial agents against Pseudomonas aeruginosa.
The Malthus-AT system provided a satisfactory method for examining the effects of permeabilizing agents on the activity of sub-inhibitory concentrations of antibacterial agents against Pseudomonas aeruginosa G48. Under this system, disodium edetate potentiated the activity of chlorhexidine diacetate (CHA), cetylpyridinium chloride, para-chlorometaxylenol and triclosan. Nitrilotriacetic acid enhanced the activity of some of the antibacterials tested, whereas sodium polyphosphate markedly reduced the efficacy of CHA.
Welsh School of Pharmacy, University of Wales Cardiff, UK.
H M
HM
Ayres
D N
DN
Payne
J R
JR
Furr
A D
AD
Russell
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002463:Cell Membrane Permeability / Q000187:drug effects*; D019343:Citric Acid / Q000494:pharmacology; D004357:Drug Synergism; D004492:Edetic Acid / Q000494:pharmacology*; D004553:Electric Conductivity; D009571:Nitrilotriacetic Acid / Q000494:pharmacology*; D010710:Phosphates / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D013644:Tartrates / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D010710:Phosphates; D013644:Tartrates; D019343:Citric Acid; D004492:Edetic Acid; D009571:Nitrilotriacetic Acid; C018279:sodium phosphate; C029768:tartaric acid