Analysis of organic acids, amino acids, and carnitine in dogs with lipid storage myopathy.
Abnormal accumulations of lipid droplets, localized predominantly in histochemical type 1 fibers, were observed in fresh frozen sections of muscle biopsies from 25 dogs with myalgia, weakness, and muscle atrophy. Compared to controls, lactic acidemia, hyperalaninemia, lactic and pyruvic aciduria, variably increased urinary excretion of carnitine esters, and muscle carnitine deficiency were present. These findings support a metabolic block in oxidative metabolism resulting in lactic acidemia in dogs with lipid storage myopathy.
Shelton
G D
GD
Department of Pathology, School of Medicine, University of California, San Diego, La Jolla 92093-0612, USA.
Nyhan
W L
WL
Kass
P H
PH
Barshop
B A
BA
Haas
R H
RH
D000143:Acids / Q000652:urine*; D000596:Amino Acids / Q000097:blood*; D000818:Animals; D002331:Carnitine / Q000378:metabolism*; D004283:Dog Diseases / Q000378:metabolism* / Q000473:pathology; D004285:Dogs; D005260:Female; D050356:Lipid Metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism / Q000473:pathology; D009135:Muscular Diseases / Q000662:veterinary*
D000143:Acids; D000596:Amino Acids; D002331:Carnitine