Absence of detectable pharmacological effects after oral administration of isoxsuprine.
Isoxsuprine is reported to be a peripheral vasodilator used in human and veterinary medicine to treat ischaemic vascular disease. In horses, it is generally administered orally to treat navicular disease and other lower limb problems. To define the scope and duration of its pharmacological responses after oral administration, 6 horses were dosed with isoxsuprine HCl (1.2 mg/kg bwt) q. 12 h for 8 days and then tested to assess the duration and extent of pharmacological actions. There was no significant difference between isoxsuprine and control treatment values for heart rate, spontaneous activity, sweat production, anal muscle tone, core and skin temperatures, and cutaneous blood flow. The lack of pharmacological effect following oral administration was in sharp contrast to the marked response following i.v. dosing reported in earlier experiments.
Harkins
J D
JD
Maxwell H. Gluck Equine Research Center and the Department of Veterinary Science, University of Kentucky, Lexington 40506, USA.
Mundy
G D
GD
Stanley
S
S
Woods
W E
WE
Sams
R A
RA
Richardson
D R
DR
Grambow
S C
SC
Tobin
T
T
D000284:Administration, Oral; D001003:Anal Canal / Q000187:drug effects / Q000502:physiology; D000821:Animal Feed; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006736:Horses / Q000502:physiology*; D007556:Isoxsuprine / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D009129:Muscle Tonus / Q000187:drug effects; D011208:Powders; D012039:Regional Blood Flow / Q000187:drug effects; D012119:Respiration / Q000187:drug effects; D012867:Skin / Q000098:blood supply; D012881:Skin Temperature / Q000187:drug effects; D013546:Sweating / Q000187:drug effects; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*
D011208:Powders; D014665:Vasodilator Agents; D007556:Isoxsuprine