[Possibilities of drug prophylaxis of adrenalin-induced glaucoma (an experimental study)].
Experiments were carried out on 30 rabbits with adrenalin glaucoma. In 10 rabbits, intravenous adrenalin was paralleled by subconjunctival antioxidant superoxide dismutase (Erysod). Increase of intraocular pressure, changes of tonographic values, accumulation of lipid peroxidation products and alteration of the drainage zone morphology were observed in animals with adrenalin glaucoma. In animals administered erysod in parallel with adrenalin, tonometric and tonographic parameters were normal. The concentration of lipid peroxidation products in the blood was virtually normal in this group. Morphological studies showed no essential differences in the structure of the anterior chamber corner in the eyes of animals treated with erysod and in intact controls. The results demonstrate the possibility of preventing the development of primary open-angle glaucoma with erysod.
Alekseev
V N
VN
Martynova
E B
EB
Korelina
V E
VE
Materova
Iu V
IuV
D000818:Animals; D000867:Anterior Chamber / Q000187:drug effects / Q000473:pathology; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology; D004837:Epinephrine; D004912:Erythrocytes / Q000201:enzymology; D005901:Glaucoma / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D015227:Lipid Peroxidation; D011817:Rabbits; D013482:Superoxide Dismutase / Q000008:administration & dosage / Q000494:pharmacology
D000975:Antioxidants; D013482:Superoxide Dismutase; D004837:Epinephrine