Beta interferon is produced by Chlamydia trachomatis-infected fibroblast-like synoviocytes and inhibits gamma interferon-induced HLA-DR expression.
Infection of fibroblast-like synovial cells with Chlamydia trachomatis (serotype D strain IC Cal 8) in culture induced the secretion of beta interferon (IFN-beta). Chlamydial infection inhibited IFN-gamma-induced expression of HLA-DR antigen in the cells. Addition of IFN-beta antibody directly to infected cultures mitigated HLA-DR inhibition, suggesting involvement of produced IFN-beta.
Institute of Medical Microbiology, Friedrich Schiller University of Jena, D-07743 Jena, Germany. Roedel@BACH.med.uni-jena.de
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J
Rödel
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A
Groh
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Vogelsang
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M
Lehmann
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M
Hartmann
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Straube
D002478:Cells, Cultured; D002692:Chlamydia trachomatis / Q000502:physiology*; D005347:Fibroblasts / Q000378:metabolism* / Q000382:microbiology; D006684:HLA-DR Antigens / Q000096:biosynthesis*; D006801:Humans; D016899:Interferon-beta / Q000378:metabolism*; D007371:Interferon-gamma / Q000037:antagonists & inhibitors / Q000502:physiology*; D013583:Synovial Membrane / Q000166:cytology
D006684:HLA-DR Antigens; D016899:Interferon-beta; D007371:Interferon-gamma