The invariant chain gene intronic enhancer shows homology to class II promoter elements.
Coordinate expression of MHC class II proteins and the class II-associated invariant chain (Ii) is important for proper MHC class II functioning in Ag processing and presentation. The coordinate regulation of these genes results, in part, from the sharing of transcriptional regulatory regions between MHC class II and Ii genes; the Ii has previously been shown to have an upstream enhancer closely related to the essential class II promoter elements. We report here the characterization of a second enhancer in the Ii gene, located within the first intron. This intronic enhancer is contained within a 155-bp region, enhances transcription from the Ii minimal promoter, and also contains elements that are homologous to class II promoter elements X1, X2, and Y boxes.
Department of Biological Sciences, Stanford University, CA 94305-5020, USA.
B B
BB
Moore
Z A
ZA
Cao
T L
TL
McRae
C H
CH
Woo
S
S
Conley
P P
PP
Jones
D000818:Animals; D000944:Antigens, Differentiation, B-Lymphocyte / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D001482:Base Composition / Q000276:immunology; D001667:Binding, Competitive / Q000276:immunology; D002460:Cell Line; D004591:Electrophoresis, Polyacrylamide Gel; D004742:Enhancer Elements, Genetic / Q000276:immunology*; D005802:Genes, MHC Class II; D000949:Histocompatibility Antigens Class II / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D007438:Introns / Q000276:immunology*; D051379:Mice; D009687:Nuclear Proteins / Q000302:isolation & purification / Q000378:metabolism; D011401:Promoter Regions, Genetic / Q000276:immunology*; D011485:Protein Binding / Q000276:immunology; D012689:Sequence Homology, Nucleic Acid; D014407:Tumor Cells, Cultured
D000944:Antigens, Differentiation, B-Lymphocyte; D000949:Histocompatibility Antigens Class II; D009687:Nuclear Proteins; C045084:invariant chain