[An electrophysiological and histological study on the neurotoxicity of lidocaine in excised rabbit cervical vagus nerve].
We studied the neurotoxic effect of lidocaine at different concentrations on the desheathed rabbit vagus nerve by measuring the amplitudes of evoked compound action potentials and the histological changes of the nerve by means of the electron microscopy after incubation in lidocaine-Ringer's bicarbonate (RB) solution. The following results were obtained. 1) Minimum concentrations of lidocaine for producing complete conduction block (minimum blocking concentration, MBC) were 0.02% for A beta and A delta fibers, and 0.03% for C fibers. 2) Irreversible conduction blocks of compound action potentials were observed in relation with lidocaine concentrations and the duration of incubation: e.g. 0.5% for 2 hours incubation was equivalent to the block with 1% for 1 hour. 3) Degenerative change of axons was revealed morphologically in the preparations exposed to 2% or a higher concentration of lidocaine. 4) Risk ratio, which means a numerical value calculated as clinical concentration/irreversible concentration with 2 hr exposure, was similar to other local anesthetics except dibucaine HCl, which shows an higher risk ratio. However, it should be noted that lidocaine has an risk of producing irreversible changes in nerve fibers, when applied to the nervous tissue at higher concentrations for longer durations.
Itoh
S
S
Department of Anesthesiology, Surugadai Nihon University Hospital, Tokyo.
Noda
K
K
D000200:Action Potentials / Q000187:drug effects; D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D001369:Axons / Q000473:pathology; D004594:Electrophysiology; D066298:In Vitro Techniques; D008012:Lidocaine / Q000494:pharmacology*; D009410:Nerve Degeneration; D009412:Nerve Fibers / Q000187:drug effects; D011817:Rabbits; D014630:Vagus Nerve / Q000187:drug effects* / Q000473:pathology / Q000502:physiology
D000779:Anesthetics, Local; D008012:Lidocaine