Urinary excretion levels of sodium and potassium in environmental cadmium-exposed subjects.
The urinary excretion levels of sodium (Na) and potassium (K) in cadmium (Cd)-exposed subjects as related with urinary beta2-microglobulin (beta2-MG) and Cd concentrations were investigated. The target population comprised of 3164 inhabitants of Japan who were more than 50 years of age and who lived in cadmium-polluted areas and 294 inhabitants who lived in non-polluted areas of Japan. A significant increase in urinary excretion of K was shown in Cd-exposed subjects although there was no significant difference in urinary excretion of Na between the Cd-exposed and non-exposed subjects. Urinary K concentrations in both sexes were significantly correlated with age, urinary beta2-MG and Cd concentrations by multiple regression analysis. Urinary Na concentration was significantly correlated with age, beta2-MG and Cd in men, but in women it was significantly associated with only the urinary beta2-MG concentration. The present study demonstrated that increased K excretion was a more sensitive effect of cadmium exposure than increased Na excretion.
Department of Hygiene, Chiba University School of Medicine, Inohana, Japan.
K
K
Monzawa
T
T
Kido
H
H
Yamaya
E
E
Kobayashi
K
K
Nogawa
D000368:Aged; D002104:Cadmium / Q000009:adverse effects* / Q000652:urine; D015331:Cohort Studies; D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000652:urine*; D012044:Regression Analysis; D012964:Sodium / Q000652:urine*; D001613:beta 2-Microglobulin / Q000652:urine
D004785:Environmental Pollutants; D001613:beta 2-Microglobulin; D002104:Cadmium; D012964:Sodium; D011188:Potassium