[Importance of the study of the expression of MIB-1 (Ki-67) for the diagnosis of endocervical glandular lesions].
The morphological criteria for the diagnosis of endocervical atypia and dysplasia are variably defined. Diagnosis is difficult. MIB-1 (Ki-67) cell proliferation-associated antigen was detected retrospectively by immunohistochemistry in 230 cervical cone specimens. The percentage of MIB-1 positive cells was 1 to 25% (median 2%) and limited to small hot spots in normal and subnormal glands (140 cases). It was 1 to 30% (median 4%) in endometrioid metaplasia and microglandular hyperplasia (55 cases); 30 to 60 (median 40%) and limited to 1-3 glands in atypia (24 cases); 45 to 60% (median 50%) and diffusely distributed in dysplasia (5 cases). In situ (3 cases) and invasive (3 cases) adenocarcinomas were characterized by a high% (> 60) of MIB-1 positive cells.
Leteurtre
E
E
Service Anatomie et Cytologie Pathologiques C, Hôpital Calmette, Lille.
Boman
F
F
Farine
M O
MO
Leroy
J L
JL
Gosselin
B
B
D000230:Adenocarcinoma / Q000175:diagnosis / Q000276:immunology; D000328:Adult; D002278:Carcinoma in Situ / Q000175:diagnosis / Q000276:immunology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis*; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis / Q000276:immunology*; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000276:immunology
D019394:Ki-67 Antigen