CNS effects of a series of 1,2,4-triazolyl heterocarboxylic derivatives.
A series of 1,2,4-triazolyl heterocarboxylic derivatives were tested for acute toxicity and CNS effects in mice. Several of these compounds demonstrated clear psychostimulant effects. Other components of the series, however, showed a definite central depressant activity. Some of the screened derivatives showed interesting anxiolytic properties.
Departamento de Farmacología, Facultad de Farmacia, Universidad de La Laguna, Tenerife, Spain.
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D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D001058:Apomorphine / Q000633:toxicity; D001522:Behavior, Animal / Q000187:drug effects; D002491:Central Nervous System Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D018491:Dopamine Agonists / Q000633:toxicity; D004357:Drug Synergism; D005260:Female; D006574:Heterocyclic Compounds, 2-Ring / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D018721:Muscarinic Agonists / Q000633:toxicity; D009125:Muscle Relaxants, Central / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D010095:Oxotremorine / Q000633:toxicity; D010424:Pentobarbital / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D014151:Anti-Anxiety Agents; D002491:Central Nervous System Agents; D018491:Dopamine Agonists; D006574:Heterocyclic Compounds, 2-Ring; D006993:Hypnotics and Sedatives; D018721:Muscarinic Agonists; D009125:Muscle Relaxants, Central; D014230:Triazoles; D010095:Oxotremorine; D010424:Pentobarbital; D001058:Apomorphine