Techniques for measuring cerebral blood flow in children.
Pathologic alterations in cerebral blood flow and metabolism commonly occur following a variety of insults to the brain. An understanding of blood flow and metabolic abnormalities and the ability to monitor and manipulate cerebral blood flow and metabolism may improve outcome following brain injury. Multiple methods have been developed in an attempt to accurately measure cerebral blood flow metabolism. Each method has its unique advantages as well as limitations. The method utilized is dependent upon the clinical situation, the type of information needed, and the availability of the technique. This review provides an overview of the theory and application of the techniques that have been used to evaluate cerebral blood flow in children.
Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA.
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Sudikoff
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Banasiak
D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000378:metabolism; D001927:Brain Diseases / Q000175:diagnosis / Q000378:metabolism; D002404:Catheterization; D002560:Cerebrovascular Circulation; D002648:Child; D003422:Critical Care / Q000379:methods* / Q000592:standards; D006801:Humans; D007601:Jugular Veins; D017078:Laser-Doppler Flowmetry; D008279:Magnetic Resonance Imaging; D008657:Metabolic Clearance Rate; D008991:Monitoring, Physiologic / Q000379:methods; D009609:Nitrous Oxide; D010092:Oximetry / Q000379:methods; D010101:Oxygen Consumption; D015203:Reproducibility of Results; D014055:Tomography, Emission-Computed; D014057:Tomography, X-Ray Computed; D017585:Ultrasonography, Doppler, Transcranial; D014980:Xenon Radioisotopes
D014980:Xenon Radioisotopes; D009609:Nitrous Oxide