Inositol phospholipids: translocation, translocation, translocation...
The pleckstrin homology (PH) domains of a number of proteins have been found to interact in vitro with inositol phospholipids; recent experiments show that these interactions may be important in directing protein translocation to specific parts of the cell following stimulus-induced lipid breakdown or synthesis.
Department of Pharmacology University of Cambridge Tennis Court Road, Cambridge CB2 1QJ, UK. rfi20@cam.ac.uk
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D000077329:Agammaglobulinaemia Tyrosine Kinase; D000818:Animals; D020690:GTPase-Activating Proteins; D007527:Isoenzymes / Q000378:metabolism; D019269:Phosphatidylinositol 4,5-Diphosphate / Q000378:metabolism; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism*; D054803:Phospholipase C delta; D051966:Phospholipase C gamma; D017346:Protein Serine-Threonine Kinases; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt; D010738:Type C Phospholipases / Q000378:metabolism; D018909:src Homology Domains
D020690:GTPase-Activating Proteins; D007527:Isoenzymes; D019269:Phosphatidylinositol 4,5-Diphosphate; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols; D011506:Proteins; D011518:Proto-Oncogene Proteins; C060974:phosphatidylinositol 3,4,5-triphosphate; D011505:Protein-Tyrosine Kinases; D000077329:Agammaglobulinaemia Tyrosine Kinase; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt; D010738:Type C Phospholipases; D054803:Phospholipase C delta; D051966:Phospholipase C gamma