Quantitation of regional cerebral blood flow increases in prefrontal cortex during a working memory task: a steady-state arterial spin-tagging study.
Steady-state arterial spin-tagging MRI approaches were used to quantitate regional cerebral blood flow increases in prefrontal cortex during a working memory ("two-back") task in six normal subjects. Statistically significant increases in cerebral blood flow in prefrontal cortex were observed in all six subjects: the average increase in cerebral blood flow in activated prefrontal cortex regions was 22 +/- 5 cc/100 g/min (23 +/- 7%). The results demonstrate that spin-tagging approaches can be used to follow focal activation in prefrontal cortex during cognitive tasks.
Ye
F Q
FQ
Clinical Brain Disorders Branch, NIMH, National Institutes of Health, Bethesda, Maryland 20892, USA.
Smith
A M
AM
Mattay
V S
VS
Ruttimann
U E
UE
Frank
J A
JA
Weinberger
D R
DR
McLaughlin
A C
AC
D000328:Adult; D001143:Arousal / Q000502:physiology*; D001783:Blood Flow Velocity / Q000502:physiology; D001931:Brain Mapping; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D017397:Prefrontal Cortex / Q000098:blood supply*; D011597:Psychomotor Performance; D012039:Regional Blood Flow / Q000502:physiology