Myocardial Epstein-Barr virus-associated cardiac smooth-muscle neoplasm arising in a cardiac transplant recipient.
Epstein-Barr virus-associated smooth muscle proliferations have been reported in immunosuppressed patients with acquired immunodeficiency syndrome and after organ transplantation. We report here a case of a histologically benign case arising in a 48-year-old male who had received immunosuppressive therapy 4 years earlier, after cardiac transplantation. In the necropsy performed for unrelated reasons, an incidental left intramyocardial tumor was discovered. The presence of Epstein-Barr virus was confirmed by EBER-1 in situ hybridization and polymerase chain reaction. To the best of our knowledge, this is the first case of an Epstein-Barr virus-associated smooth muscle proliferation arising in the heart after cardiac transplantation and should be added to the potential complications of this kind of procedure.
Department of Hematology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
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J
Anguita
M L
ML
Rico
J
J
Palomo
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P
Muñoz
V
V
Preciado
J
J
Menárguez
D017544:Aortic Aneurysm, Abdominal / Q000473:pathology; D001019:Aortic Rupture / Q000473:pathology; D002455:Cell Division / Q000502:physiology*; D003324:Coronary Artery Disease / Q000473:pathology; D016027:Heart Transplantation / Q000473:pathology*; D006352:Heart Ventricles / Q000473:pathology; D006566:Herpesviridae Infections / Q000473:pathology*; D004854:Herpesvirus 4, Human; D006801:Humans; D008297:Male; D008875:Middle Aged; D009130:Muscle, Smooth / Q000473:pathology*; D014412:Tumor Virus Infections / Q000473:pathology*