The IGF system during fetal-placental development of the mouse.
Insulin-like growth factors (IGF-I and -II) promote cellular mitosis and differentiation and have been implicated in fetal and placental growth. Together with the IGF receptors and IGF binding proteins (IGFBPs) they form a complex network, with tissue specific activity. This review will discuss the data generated to elucidate the functions of the IGF system during mouse development.
van Kleffens
M
M
Department of Pediatrics, Erasmus University Rotterdam, The Netherlands. vankleffens@pa1.fgg.eur.nl
Groffen
C
C
Lindenbergh-Kortleve
D J
DJ
van Neck
J W
JW
González-Parra
S
S
Dits
N
N
Zwarthoff
E C
EC
Drop
S L
SL
D000818:Animals; D017209:Apoptosis; D005314:Embryonic and Fetal Development / Q000502:physiology*; D005260:Female; D017353:Gene Deletion; D018969:Insulin-Like Growth Factor Binding Proteins / Q000032:analysis / Q000235:genetics; D051379:Mice; D008822:Mice, Transgenic; D010920:Placenta / Q000502:physiology*; D011247:Pregnancy; D017527:Receptor, IGF Type 2 / Q000235:genetics; D013002:Somatomedins / Q000032:analysis / Q000235:genetics / Q000502:physiology*
D018969:Insulin-Like Growth Factor Binding Proteins; D017527:Receptor, IGF Type 2; D013002:Somatomedins