[Angiogenesis as prognostic factor in malignant tumors].
It is now generally accepted that angiogenesis is critical for tumor progression and metastasis. Angiogenic parameters like vascular density and expression of angiogenic factors have been linked to the outcome of a broad spectrum of cancers. Most of these studies report a worsening prognosis in cases of higher vascular density and increased expression of angiogenic factors. Furthermore, preliminary reports suggest that angiogenic activity may predict the success of some cytotoxic therapies. The evidence of angiogenesis as a fundamental process in cancer development led to a large number of studies testing anti-angiogenic strategies as monotherapy or in combination with radiation and chemotherapy.
Klinik für Radio-Onkologie mit Abteilung für Medizinische Strahlenphysik, Universität Bern, Inselspital.
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Aebersold
D000818:Animals; D006801:Humans; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000098:blood supply*; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D011379:Prognosis