Deamination of cyclaradine by adenosine deaminase under high pressure.
The deamination of cyclaradine corresponding to a carbocyclic analogue of ara-A having anti-HSV activity by adenosine deaminase was examined under various pressure. The deamination of (+)- and (+/-)-cyclaradine was remarkably facilitated by high pressure, and the rate was increased with increasing of pressure. However, (-)-cyclaradine was not deaminated even under high pressure.
Pharmaceutical Institute, Tohoku University, Sendai, Japan.
N
N
Katagiri
H
H
Kokufuda
M
M
Makino
R
R
Vince
C
C
Kaneko
D000243:Adenosine Deaminase / Q000378:metabolism*; D000998:Antiviral Agents / Q000378:metabolism; D003641:Deamination; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009705:Nucleosides / Q000378:metabolism; D011312:Pressure; D013237:Stereoisomerism; D014740:Vidarabine / Q000031:analogs & derivatives* / Q000378:metabolism
D000998:Antiviral Agents; D009705:Nucleosides; C014387:carbocyclic arabinosyladenine; D000243:Adenosine Deaminase; D014740:Vidarabine