Listeria monocytogenes as a probe to study cell-mediated immunity.
The intracellular bacterium Listeria monocytogenes continues to serve as a model to define general paradigms of cell-mediated immunity. Genetic manipulations of the bacterium and its murine host have allowed us to begin dissecting the intricate interactions between this bacterium and the immune system. As a result, we have gained new insights into the mechanisms of immune surveillance, achieved better understanding of bacterial tactics for immune evasion and developed novel strategies in vaccine development.
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Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia 19104-6076, USA. hshen@mail.med.upenn.edu
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Fan
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D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D017209:Apoptosis; D007111:Immunity, Cellular / Q000276:immunology*; D008089:Listeria monocytogenes / Q000276:immunology*