Complement receptor 2 in the regulation of the immune response.
Antigens coated with split products of C3, the result of complement activation, are capable of crosslinking the complement receptor 2 (CR2, CD21) and the antigen receptor on the surface of B cells simultaneously. This dual recognition leads to increased cell proliferation and differentiation and enhanced antibody production. CR2 is also considered to be a regulator of the B cell response to antigen. In this review we summarize the biology of the CR2 and focus on its essential role in generating an effective B cell response to antigenic stimuli. The involvement of CR2 in the pathophysiology of infectious and autoimmune diseases is also discussed.
Department of Clinical Physiology, Walter Reed Army Institute of Research, Washington, DC, 20307, USA.
M
M
Tolnay
G C
GC
Tsokos
D000917:Antibody Formation / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D017464:Receptors, Complement 3d / Q000502:physiology*
D017464:Receptors, Complement 3d