Effect of medium- and long-chain triglycerides on lower esophageal sphincter pressure: role of CCK.
Fat meals are known to decrease lower esophageal sphincter (LES) pressure, possibly through postprandial CCK release. Dietary fat consists mainly of long-chain triglycerides (LCT), which potently stimulate CCK secretion. This effect contrasts with that of medium-chain triglycerides (MCT), which do not induce CCK release. We recorded LES pressure and gallbladder volume in six healthy subjects on five separate occasions during intraduodenal administration of 1) saline control, 2) LCT, 3) MCT, 4) LCT during intravenous infusion of the CCK receptor antagonist loxiglumide, and 5) MCT together with loxiglumide. LES pressure decreased significantly during administration of both LCT and MCT. Loxiglumide completely prevented the reduction in LES pressure during intraduodenal LCT, but not during intraduodenal MCT. Gallbladder volume decreased during LCT, but not during MCT. It is concluded that intraduodenal administration of equimolar amounts of both LCT and MCT significantly reduces LES pressure. The effect of LCT on LES pressure is mediated by CCK. The effect of MCT is not dependent on CCK, since MCT does not release CCK and loxiglumide does not prevent the MCT-induced reduction in LES pressure.
Department of Gastroenterology-Hepatology, Leiden University Medical Center, Leiden, The Netherlands.
M
M
Ledeboer
A A
AA
Masclee
I
I
Biemond
C B
CB
Lamers
D000328:Adult; D002766:Cholecystokinin / Q000502:physiology*; D004041:Dietary Fats / Q000494:pharmacology; D004386:Duodenum / Q000187:drug effects*; D004943:Esophagogastric Junction / Q000187:drug effects* / Q000502:physiology*; D005260:Female; D005704:Gallbladder / Q000000981:diagnostic imaging; D006727:Hormone Antagonists / Q000494:pharmacology; D006801:Humans; D007262:Infusions, Intravenous; D007700:Kinetics; D008297:Male; D011312:Pressure; D011377:Proglumide / Q000008:administration & dosage / Q000031:analogs & derivatives; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors; D014280:Triglycerides / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D014463:Ultrasonography
D004041:Dietary Fats; D006727:Hormone Antagonists; D011949:Receptors, Cholecystokinin; D014280:Triglycerides; C053737:loxiglumide; D002766:Cholecystokinin; D011377:Proglumide