T-cell-independent antiviral antibody responses.
Recent work has shown that viruses can act in vivo as T-cell-independent antigens, eliciting protective, isotype-switched antibodies in the absence of conventional TCR alpha beta+ T cell help. Inactivated virus or virus-like particles can stimulate IgM production, but factors induced during live virus infection appear to be required to induce the isotype switch that leads to IgG or IgA responses.
Szomolanyi-Tsuda
E
E
Department of Pathology, University of Massachusetts Medical Center, Worcester 01655, USA. Eva.Szomolanyi-Tsuda@banyan.ummed.edu
Welsh
R M
RM
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis / Q000276:immunology*; D000956:Antigens, Viral / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D018858:Germinal Center; D006801:Humans; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000914:Antibodies, Viral; D000956:Antigens, Viral