Blood cell precursors in context. Composition of the bone marrow microenvironment that supports B lymphopoiesis.
New molecular approaches are rapidly yielding information about the composition of bone marrow and culture studies suggest possible functions for many molecules in that organ. However, the marrow is extraordinarily complex with respect to interactions between cells and their behaviour may not be adequately modeled in culture. It is becoming apparent that post-translational modifications and function of proteins can be highly influenced by the cellular and extracellular environment. Therefore, in vivo studies will continue to be important for understanding this remarkable organ.
Oklahoma Medical Research Foundation, Oklahoma City 73104, USA. paul-kincade@ornrf.ouhsc.edu
P W
PW
Kincade
Y
Y
Yamashita
L
L
Borghesi
K
K
Medina
K
K
Oritani
D017209:Apoptosis; D001402:B-Lymphocytes / Q000166:cytology*; D001854:Bone Marrow Cells / Q000502:physiology*; D002470:Cell Survival; D002478:Cells, Cultured; D005260:Female; D012739:Gonadal Steroid Hormones / Q000502:physiology; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D019812:Heparan Sulfate Proteoglycans / Q000502:physiology; D006801:Humans; D018960:Hyaluronan Receptors / Q000502:physiology; D008297:Male; D011247:Pregnancy; D017154:Stromal Cells / Q000502:physiology
D012739:Gonadal Steroid Hormones; D019812:Heparan Sulfate Proteoglycans; D018960:Hyaluronan Receptors