A possible approach to the treatment of polycystic ovarian syndrome using focused ultrasound.
A new method of treatment for infertility caused by polycystic ovarian syndrome (PCOS) using thermal lesion formation by high intensity ultrasound has been suggested. Current options for PCOS therapy and the achievements of focused ultrasound surgery technique are reviewed and discussed. A prototype of a low-cost commercial device for the treatment of PCOS has been designed and tested to prove the feasibility of the method. A transducer with curvature radius of 36 mm and aperture diameter of 36 mm, operating at 0.97 MHz, was designed and tested. It provided a maximum acoustic power output of 180 W. Well-defined tissue damage was obtained within 10 s in a pig's liver in vitro at 3 cm depth within an area 5 mm in diameter and 12 mm in length without damaging the surrounding tissue. Evaluation of the size of the lesions produced at different frequencies, sonication times and output power has been carried out by visual inspection of the colour changes in cut tissue sections. Results demonstrate that a surgical tool based on the method suggested should be feasible and warrants further investigation.
School of Physics, University of Bath, UK.
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AG
Moussatov
A C
AC
Baker
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FA
Duck
D000162:Acoustics / Q000295:instrumentation; D000818:Animals; D003116:Color; D004867:Equipment Design; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000628:therapy; D008099:Liver / Q000473:pathology; D008422:Materials Testing; D011085:Polycystic Ovary Syndrome / Q000628:therapy*; D013499:Surface Properties; D013552:Swine; D013696:Temperature; D013997:Time Factors; D014159:Transducers; D014464:Ultrasonic Therapy / Q000295:instrumentation / Q000379:methods