Possible involvement of lipid peroxidation in the inhibition of type I iodothyronine 5'-monodeiodinase activity by lead in chicken liver.
The possible involvement of lipid peroxidation (LPO) in the lead-induced inhibition of type I iodothyronine 5'-monodeiodinase activity (5'-D) has been worked out in chicken liver. Lead nitrate (1.5 mg per bird per day) for 30 days increased the lipid peroxidative process with a concomitant decrease in 5'-D activity in chicken liver. Also, a significant decrease in serum triiodothyronine (T3) concentration and an increase in serum thyroxine (T4) concentration were observed. The data suggest that lead-induced inhibition of type I 5'-D activity in chicken liver is mediated through the lipid peroxidative process.
Thyroid Research Unit, School of Life Sciences, D. A. University, Indore, India.
S S
SS
Chaurasia
P
P
Gupta
P K
PK
Maiti
A
A
Kar
D000818:Animals; D002645:Chickens; D007453:Iodide Peroxidase / Q000037:antagonists & inhibitors*; D007854:Lead / Q000633:toxicity*; D015227:Lipid Peroxidation; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D013961:Thyroid Gland / Q000187:drug effects; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D014284:Triiodothyronine; D007854:Lead; D007453:Iodide Peroxidase; D013974:Thyroxine