Development of a high-throughput in vitro bioassay to assess potencies of progestagenic compounds using chinese hamster ovary cells stably transfected with the human progesterone receptor and a luciferase reporter system.
Schoonen
W G
WG
Department of Endocrinology, N. V. Organon, Molenstraat 110, Oss, 5340 BH, The Netherlands.
de Ries
R J
RJ
Joosten
J W
JW
Mathijssen-Mommers
G J
GJ
Kloosterboer
H J
HJ
D000818:Animals; D001681:Biological Assay / Q000295:instrumentation / Q000379:methods* / Q000592:standards; D016466:CHO Cells; D006224:Cricetinae; D017930:Genes, Reporter; D006801:Humans; D008156:Luciferases / Q000235:genetics*; D008904:Miniaturization; D011282:Pregnenediones / Q000494:pharmacology; D045167:Progesterone Congeners / Q000494:pharmacology*; D011980:Receptors, Progesterone / Q000235:genetics*; D014162:Transfection
D011282:Pregnenediones; D045167:Progesterone Congeners; D011980:Receptors, Progesterone; C020175:16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione; D008156:Luciferases