Human T-lymphotropic virus type 2 (HTLV-2) provirus in circulating cells of the monocyte/macrophage lineage in patients dually infected with human immunodeficiency virus type 1 and HTLV-2 and having predominantly sensory polyneuropathy.
We investigated the presence of human T-lymphotropic virus type 2 (HTLV-2) DNA in the peripheral blood mononuclear cell subsets obtained from 18 patients coinfected with human immunodeficiency virus type 1 and HTLV-2, 6 of whom also had predominantly sensory polyneuropathy (PSP). HTLV-2 DNA and RNA were found in CD8- and CD19-positive cells, and, for patients with PSP, in CD14-positive cells as well. Furthermore, the patients with PSP had higher proviral loads than those without PSP.
Istituto di Malattie Infettive e Tropicali, Università degli Studi di Milano," Milan, Italy. zehender@imiucca.csi.unimi.it
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G
Zehender
L
L
Meroni
S
S
Varchetta
C
C
De Maddalena
B
B
Cavalli
M
M
Gianotto
A B
AB
Bosisio
C
C
Colasante
G
G
Rizzardini
M
M
Moroni
M
M
Galli
D017088:AIDS-Related Opportunistic Infections / Q000821:virology*; D000328:Adult; D004279:DNA, Viral / Q000097:blood; D015480:Deltaretrovirus Antibodies / Q000097:blood; D005069:Evaluation Studies as Topic; D005260:Female; D015497:HIV-1; D015491:HTLV-II Infections / Q000821:virology*; D015367:Human T-lymphotropic virus 2 / Q000235:genetics*; D006801:Humans; D008264:Macrophages / Q000821:virology*; D008297:Male; D008432:Mathematical Computing; D008875:Middle Aged; D009000:Monocytes / Q000821:virology*; D010523:Peripheral Nervous System Diseases / Q000150:complications / Q000821:virology; D016133:Polymerase Chain Reaction; D011533:Proviruses / Q000235:genetics*; D012367:RNA, Viral; D012680:Sensitivity and Specificity; D016176:T-Lymphocyte Subsets / Q000821:virology
D004279:DNA, Viral; D015480:Deltaretrovirus Antibodies; D012367:RNA, Viral