Ethylene glycol poisoning in a child treated with 4-methylpyrazole.
OBJECTIVE
The alcohol dehydrogenase inhibitor 4-methylpyrazole (4-MP) is a new antidote of ethylene glycol (EG) intoxication. The purpose of the present case report was to demonstrate 4-MP efficiency in EG poisoning in a 4-year-old child.


RESULTS
4-MP Treatment was performed 7 hours after EG ingestion. Plasma EG and 4-MP concentrations were measured 2 hours after each infusion of 4-MP. Plasma 4-MP concentrations were in the range of the values reported to block EG metabolism. The efficiency of 4-MP treatment was confirmed by the rapid correction of metabolic acidosis without alkalization and by the increase in EG half-life. No adverse effect of 4-MP was observed.


CONCLUSIONS
This child ingested a potentially lethal dose of EG despite a high concentration of bittering agent in antifreeze. EG poisoning was treated efficiently by 4-MP without recourse to hemodialysis.
Harry
P
P
Centre Anti-poison, Centre Hospitalier Universitaire, Angers, France.
Jobard
E
E
Briand
M
M
Caubet
A
A
Turcant
A
A
D000931:Antidotes / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid; D004334:Drug Administration Schedule; D019855:Ethylene Glycol / Q000506:poisoning*; D005260:Female; D000077604:Fomepizole; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D011041:Poisoning / Q000175:diagnosis / Q000188:drug therapy*; D011720:Pyrazoles / Q000097:blood / Q000627:therapeutic use*
D000931:Antidotes; D011720:Pyrazoles; D000077604:Fomepizole; D019855:Ethylene Glycol