Inflammatory leiomyosarcoma may be characterized by specific near-haploid chromosome changes.
Identical near-haploid karyotypes with 28, X, +5, +18, +20, +21, +22 were found in two cases of inflammatory leiomyosarcoma, one of which had been reported previously as malignant fibrous histiocytoma. This abnormality may identify these tumours as a separate entity within this group of sarcomas.
Centre for Human Genetics, University of Leuven, Belgium.
P
P
Dal Cin
R
R
Sciot
C D
CD
Fletcher
I
I
Samson
R
R
De Vos
N
N
Mandahl
H
H
Willén
O
O
Larsson
H
H
Van den Berghe
D000328:Adult; D003937:Diagnosis, Differential; D006238:Haploidy; D018219:Histiocytoma, Benign Fibrous / Q000175:diagnosis / Q000235:genetics; D006801:Humans; D007621:Karyotyping; D007890:Leiomyosarcoma / Q000175:diagnosis / Q000235:genetics* / Q000648:ultrastructure; D008297:Male; D012983:Soft Tissue Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000648:ultrastructure