YAC/STS map of 15Mb of Xp21.3-p11.3, at 100kb resolution, with refined comparisons of genetic distances and DMD structure.
The 15<HSP SP = "0.25">Mb region between DXS997 and DXS8054 in Xp21.3-p11.3 has been mapped at seven-fold average coverage in yeast artificial chromosomes (YACs) and 100 kb inter-sequence tagged site (STS) distance. YACs from six different collections show self-consistent maps. The STSs include 18 (CA) repeat and one tetranucleotide repeat marker that detect polymorphism, as well as eight well-studied genes, a second site for MXS1 sequences, and three expressed sequence tags (ESTs). One of the ESTs maps to intron 7 of Duchenne muscular dystrophy, and seems to be a processed intronic sequence with a poly(A) tail.
Washington University School of Medicine, Center for Genetics in Medicine, 660 South Euclid Avenue, Box 8232, St. Louis, MO 63110, USA.
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Nagaraja
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Jermak
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Trusgnich
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Yoon
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MacMillan
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McCauley
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Brownstein
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Schlessinger
D001483:Base Sequence; D002874:Chromosome Mapping; D018244:Chromosomes, Artificial, Yeast; D017931:DNA Primers; D018900:Dinucleotide Repeats; D005819:Genetic Markers; D014644:Genetic Variation; D015894:Genome, Human; D006801:Humans; D008969:Molecular Sequence Data; D009136:Muscular Dystrophies / Q000235:genetics*; D016133:Polymerase Chain Reaction; D016324:Sequence Tagged Sites; D014158:Transcription, Genetic; D014960:X Chromosome
D017931:DNA Primers; D005819:Genetic Markers