Pre-B acute lymphoblastic leukemia in a 3-year-old boy with pre-acute myelogenous leukemia myelodysplastic syndrome: cytogenetic evidence of common early progenitor cell ontogeny.
OBJECTIVE
Myelodysplastic syndromes in children commonly evolve into acute leukemia, usually acute myelogenous leukemia (AML) and rarely acute lymphoblastic leukemia (ALL). The lineage of the leukemia can be predicted based on characteristic morphologic and cytogenetic findings of the marrow and peripheral blood.


METHODS
A 3-year-old boy had refractory anemia with excess blasts and abnormalities suggestive of pre-AML with highly unusual cytogenetic changes. ALL of pre-B phenotype developed.


RESULTS
Leukoerythroblastic anemia, pseudo Pelger-Huet neutrophils, and dysmyelopoietic hyperplasia of the marrow suggested likely early progression to AML. Complex cytogenetic abnormalities (monosomy 17 and 20, ring chromosome 11 with deletion of bands q23, and a derivative dicentric chromosome 12) were present in both the myelodysplastic marrow and the subsequent ALL.


CONCLUSIONS
This case presents cytogenetic evidence of common early progenitor cell ontogeny of both malignancies (refractory anemia with excess blasts and ALL).
Rossbach
H C
HC
Division of Pediatric Hematology/Oncology and Bone Marrow Transplantation, All Children's Hospital, University of South Florida College of Medicine, St. Petersburg, USA.
Sutcliffe
M J
MJ
Chamizo
W
W
Haag
M M
MM
Grana
N H
NH
Washington
K R
KR
Barbosa
J L
JL
D000754:Anemia, Refractory, with Excess of Blasts / Q000235:genetics / Q000473:pathology*; D000782:Aneuploidy; D001853:Bone Marrow / Q000473:pathology; D019070:Cell Lineage; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002880:Chromosomes, Human, Pair 11 / Q000648:ultrastructure; D002881:Chromosomes, Human, Pair 12 / Q000648:ultrastructure; D002886:Chromosomes, Human, Pair 17; D002890:Chromosomes, Human, Pair 20; D018450:Disease Progression; D017809:Fatal Outcome; D006412:Hematopoietic Stem Cells / Q000473:pathology*; D006801:Humans; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008297:Male; D009006:Monosomy; D014411:Neoplastic Stem Cells / Q000473:pathology*; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics / Q000473:pathology*; D012303:Ring Chromosomes; D014178:Translocation, Genetic