Benefit of screening mammography in women aged 40-49: a new meta-analysis of randomized controlled trials.
Eight randomized controlled trials (RCTs) of screening mammography have been conducted involving women aged 40-49 at entry. Current data are now available from these trials at 10.5 to 18 years of follow-up (average follow-up time: 12.7 years). Meta-analysis has been performed using a Mantel-Haenszel estimator method to combine current follow-up data from the eight RCTs of mammography that included women aged 40-49 at entry, including new follow-up data presented at the NIH Consensus Development Conference held January 21-23, 1997. Combining the most recent follow-up data on women aged 40-49 at entry into all eight RCTs yields a statistically significant 18% mortality reduction among women invited to screening mammography (relative risk: 0.82; 95% confidence interval: 0.71-0.95). Combining all current follow-up data on women aged 40-49 at entry into the five Swedish RCTs yields a statistically significantly 29% mortality reduction among women invited to screening (relative risk: 0.71; 95% confidence interval: 0.57-0.89). Meta-analysis including the most recent follow-up data from all eight RCTs involving women aged 40-49 at entry demonstrates for the first time a statistically significant mortality reduction due to regular screening mammography in women of this age group.
Department of Radiology, University of Colorado Health Sciences Center, Denver 80262, USA.
R E
RE
Hendrick
R A
RA
Smith
J H
JH
Rutledge
C R
CR
Smart
D000328:Adult; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000401:mortality / Q000517:prevention & control*; D005260:Female; D006801:Humans; D016013:Likelihood Functions; D008327:Mammography; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment; D015996:Survival Rate