A putative human papillomavirus type 57 new subtype isolated from plantar epidermoid cysts without intracytoplasmic inclusion bodies.
Human papillomavirus type 60 (HPV-60) is the only virus type that has been identified in epidermoid cysts. In this study, HPV-57 DNA was found in three out of 18 plantar epidermoid cysts with different histological features from HPV-60-associated cysts, using PCR and Southern hybridization. The HPV-57-associated cysts had features resembling an HPV-2-specific cytopathic effect. The sequences of two HPV-57 DNA clones isolated from two patients were identical, but differed at some positions from those of HPV-57a and HPV-57b. This putative new subtype was tentatively designated as HPV-57c, and may be associated with plantar epidermoid cysts showing histological features resembling the HPV-2 cytopathic effect.
Kitasato
H
H
Institute of Medical Science, St Marianna University School of Medicine, Miyamae, Kawasaki, Japan. hkita@med.kitasato-u.ac.jp
Egawa
K
K
Honda
Y
Y
Ono
T
T
Mizushima
Y
Y
Kawai
S
S
D000595:Amino Acid Sequence; D001483:Base Sequence; D004279:DNA, Viral; D004814:Epidermal Cyst / Q000473:pathology / Q000821:virology*; D005534:Foot Diseases / Q000473:pathology / Q000821:virology*; D006801:Humans; D007181:Inclusion Bodies, Viral; D008969:Molecular Sequence Data; D027383:Papillomaviridae / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification
D004279:DNA, Viral