Myolipoma of the eyelid.
BACKGROUND
This report describes the pathology of a myolipoma which occurred in the eyelid. Myolipoma is a benign hamartomatous tumour in which smooth muscle cells are interspersed with adipocytes. PATIENT DETAILS: An irregular yellowish tumour (30 x 25 mm) with illdefined borders had been present for 50 years in the medial part of the left lower eyelid of a 67-year-old woman. The tumour was excised and studied by conventional histology, immunohistochemistry and transmission electron microscopy.


RESULTS
The tumour was formed by bundles of spindle-shaped cells with cigarshaped nuclei intermingled with multiloculated clear cells containing small eccentric nuclei. By immunohistochemistry, positive staining of the spindle cells was restricted to smooth muscle actin and desmin; the clear cells were non-reactive with the immunohistochemical panel, but fat was identified within the cytoplasm. The ultrastructural features of the spindle cells were those of a leiomyoma, while the clear cells were classified as adipocytes.


CONCLUSIONS
This tumour was considered to originate from the media of blood vessels within the tumour.
Sharara
N
N
Department of Pathology, University of Glasgow, UK.
Lee
W R
WR
Weir
C
C
D000199:Actins / Q000378:metabolism; D017667:Adipocytes / Q000378:metabolism / Q000648:ultrastructure; D000368:Aged; D005142:Eyelid Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007381:Intermediate Filament Proteins / Q000378:metabolism; D008067:Lipoma / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D018396:Mucin-1 / Q000378:metabolism; D009130:Muscle, Smooth / Q000378:metabolism / Q000648:ultrastructure; D008941:Spindle Apparatus / Q000378:metabolism / Q000648:ultrastructure
D000199:Actins; D007381:Intermediate Filament Proteins; D018396:Mucin-1