Sodium pentosan polysulphate--a novel inhibitor of urinary risk factors and enzymes in experimental urolithiatic rats.
Sodium pentosan polysulphate (SPP) has been shown to inhibit calcium oxalate crystallization in vitro. Here, the effect of SPP was studied on in vivo crystallization. Ammonium oxalate was used as the inducer of calcium oxalate crystallization in rats and the effect of SPP on in vivo crystallization factor is reported. The increased excretions of stone forming constituents associated with urinary marker enzymes are the salient features observed in experimental rats. Sodium pentosan polysulphate administration brought about a significant reduction in urinary stone forming constituents. It also decreased the extent of renal tubular damage as evidenced from the reduced level of marker enzymes in urine. These observations highlight the inhibitory capacity of SPP against in vivo calcium oxalate crystallization.
Department of Biochemistry, University of Madras, India.
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Senthil
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Malini
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Varalakshmi
D000818:Animals; D002129:Calcium Oxalate / Q000652:urine; D003460:Crystallization; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D004798:Enzymes / Q000652:urine; D008297:Male; D010426:Pentosan Sulfuric Polyester / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014545:Urinary Calculi / Q000517:prevention & control* / Q000652:urine
D004791:Enzyme Inhibitors; D004798:Enzymes; D002129:Calcium Oxalate; D010426:Pentosan Sulfuric Polyester