Adjuvant trazodone in the treatment of alcoholism: an open study.
Serotonergic drugs have been proven to be helpful to alcoholics in maintaining abstinence. In this open study, we report that the atypical antidepressant trazodone at low doses was able to significantly decrease craving for alcohol, depressive, and anxious symptoms in a number (25) of detoxified alcohol-dependent subjects after 3 months of treatment. Trazodone may, therefore, be an adjuvant in the therapy of alcoholism.
Drug Addiction Unit, Institute of Psychiatry, Faculty of Medicine, Catholic University, Rome, Italy.
L
L
Janiri
A
A
Hadjichristos
A
A
Buonanno
R
R
Rago
P
P
Mannelli
S
S
de Risio
D000437:Alcoholism / Q000188:drug therapy* / Q000523:psychology / Q000534:rehabilitation; D001007:Anxiety / Q000150:complications / Q000188:drug therapy; D017024:Chemotherapy, Adjuvant; D003863:Depression / Q000150:complications / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D014196:Trazodone / Q000627:therapeutic use*
D017367:Selective Serotonin Reuptake Inhibitors; D014196:Trazodone