Treatment of bacterial vaginosis with oral or vaginal ornidazole, secnidazole and metronidazole.
OBJECTIVE
To evaluate the clinical efficacy and tolerance of oral or vaginal ornidazole, secnidazole and metronidazole or their combinations for treatment of bacterial vaginosis.


METHODS
In an open, randomized, prospective study, 152 patients with bacterial vaginosis according to Amsel's criteria were included into the study. The patients were divided into eight groups: (1) oral ornidazole 2 x 500 mg/day for 5 days; (2) vaginal ornidazole 500 mg/day for 5 days; (3) oral and vaginal ornidazole for 5 days; (4) oral secnidazole 2 g in a single dose; (5) oral secnidazole 2 g in a single dose and vaginal ornidazole 500 mg/day for 5 days; (6) oral secnidazole 2 g in a single dose and vaginal metronidazole 2 x 500 mg/day for 7 days; (7) oral ornidazole 2 x 500 mg/day for 5 days and vaginal metronidazole 2 x 500 mg/day for 7 days; and (8) vaginal metronidazole 2 x 500 mg/day for 7 days. None of the partners received any treatment.


RESULTS
We found a 100% cure rate in both oral and vaginal ornidazole and oral secnidazole-vaginal metronidazole groups.


CONCLUSIONS
Vaginal treatments including ornidazole and metronidazole are not as effective as both oral and vaginal drug combinations.
Saraçoğlu
F
F
Department of Obstetrics and Gynecology, Numune Hospital, Ankara, Turkey.
Göl
K
K
Sahin
I
I
Türkkani
B
B
Atalay
C
C
Oztopçu
C
C
D000282:Administration, Intravaginal; D000284:Administration, Oral; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D009950:Ornidazole / Q000008:administration & dosage*; D012008:Recurrence; D016896:Treatment Outcome; D016585:Vaginosis, Bacterial / Q000188:drug therapy*
D000890:Anti-Infective Agents; D008795:Metronidazole; D009950:Ornidazole; C016724:secnidazole