An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators.
A number of S-nitrosated compounds derived from 1-thiosugars (glucose, galactose, xylose, maltose, and lactose) have been prepared and characterized. Most of the compounds obtained were unstable either as solids or in solution. However, S-nitroso-1-thio-2,3,4,6-tetra-O-acetylglucopyranose was stable enough to examine as a vasodilator using an isolated rat tail artery model. It also proved effective in human cutaneous vascular smooth muscle relaxation when delivered transdermally.
School of Chemistry and Centre for Biomolecular Sciences, University of St Andrews, Fife, Scotland, United Kingdom.
A R
AR
Butler
R A
RA
Field
I R
IR
Greig
F W
FW
Flitney
S K
SK
Bisland
F
F
Khan
J J
JJ
Belch
D000818:Animals; D001158:Arteries / Q000187:drug effects / Q000502:physiology; D002241:Carbohydrates / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009603:Nitroso Compounds / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013623:Tail / Q000098:blood supply; D014665:Vasodilator Agents / Q000737:chemistry / Q000494:pharmacology*
D002241:Carbohydrates; D009603:Nitroso Compounds; D014665:Vasodilator Agents