A novel SCG10-related gene uniquely expressed in the nervous system.
We have isolated a novel cDNA (HiAT3: hippocampus abundant transcript 3) in the course of screening for genes that are preferentially expressed in neonatal mouse hippocampus using random 3'-directed cDNA sequencing approach. It encodes a 180-aa protein that has high similarity to SCG10, a neuron-specific negative regulator of microtubule dynamics during neurite outgrowth. The expression of HiAT3 is limited to neurons and peaks about 1 week after birth. The identification of HiAT3 suggests that there may be an elaborate destabilizing regulation for microtubule dynamics in neurons in addition to the stabilizing effect of multiple microtubule-associated proteins (MAPs).
Institute for Molecular, Cellular Biology, Osaka University, Yamada-oka, Suita, Osaka 565-0871, Japan.
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N
Matsuo
S
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Kawamoto
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Matsubara
K
K
Okubo
D000595:Amino Acid Sequence; D000818:Animals; D000831:Animals, Newborn; D001483:Base Sequence; D001921:Brain / Q000378:metabolism*; D002135:Calcium-Binding Proteins; D018076:DNA, Complementary; D005786:Gene Expression Regulation; D006624:Hippocampus / Q000378:metabolism*; D047908:Intracellular Signaling Peptides and Proteins; D051379:Mice; D008810:Mice, Inbred C57BL; D008868:Microtubule Proteins; D008870:Microtubules / Q000378:metabolism; D008969:Molecular Sequence Data; D009414:Nerve Growth Factors / Q000737:chemistry / Q000235:genetics*; D009474:Neurons / Q000378:metabolism*; D009479:Neuropeptides / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics*; D009928:Organ Specificity; D010750:Phosphoproteins / Q000737:chemistry / Q000235:genetics; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D050777:Stathmin; D014158:Transcription, Genetic
D002135:Calcium-Binding Proteins; D018076:DNA, Complementary; D047908:Intracellular Signaling Peptides and Proteins; D008868:Microtubule Proteins; D009414:Nerve Growth Factors; D009479:Neuropeptides; D010750:Phosphoproteins; D050777:Stathmin; C493994:Stmn1 protein, mouse; C512849:Stmn2 protein, mouse; C491793:Stmn3 protein, mouse