Echocardiographic evaluation of cardiac valvular abnormalities in adults with Down's syndrome.
It is well known that congenital heart abnormalities are common in children with Down's syndrome. However there are few studies on cardiac abnormalities in adults with Down's syndrome. Therefore, we estimated cardiac abnormalities by means of echocardiography in 30 institutionalized Japanese adults with Down's syndrome, but without cardiac symptoms. Two-dimensional echocardiography showed an incidence of 26.7% in mitral valve prolapse and 20% increase of echo brightness in the mitral valve. Doppler echocardiography revealed an incidence of 16.7% in mitral valve regurgitation, and 13.3% in aortic valve regurgitation. Thus, even adults with Down's syndrome who are apparently free of cardiac symptoms may be at risk for valvular disease.
Hamada
T
T
Department of Clinical and Laboratory Medicine, Fukui Medical University, Japan. thamada@fmsrsa.fukui-med.ac.jp
Gejyo
F
F
Koshino
Y
Y
Murata
T
T
Omori
M
M
Nishio
M
M
Misawa
T
T
Isaki
K
K
D000328:Adult; D001022:Aortic Valve Insufficiency / Q000150:complications / Q000000981:diagnostic imaging*; D004314:Down Syndrome / Q000150:complications*; D018618:Echocardiography, Doppler, Color; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D008945:Mitral Valve Prolapse / Q000150:complications / Q000000981:diagnostic imaging*; D012307:Risk Factors; D014262:Tricuspid Valve Insufficiency / Q000150:complications / Q000000981:diagnostic imaging*