Endothelial dysfunction and its role in the cycle of cardiovascular disease.
Over the past 10 years there have been significant advances in the understanding of multiple mechanisms in endothelial dysfunction and the association of endothelial dysfunction with a wide spectrum of cardiovascular diseases. An overview of normal endothelial function and endothelial dysfunction, and a unifying model to illustrate the cascade of events that occur in the coronary artery disease process are presented.
University of Florida, Division of Cardiovascular Medicine, Gainsville 32610-0277, USA. pepincj@medicine.ufl.edu
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Pepine
D003327:Coronary Disease / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans