Quality control in manufacturing process by near infrared spectroscopy.
The combination of a pattern recognition technique with near infrared spectroscopy (NIR) to determine the conformity of a pharmaceutical mixture can be used in the routine checking of a pharmaceutical product. All the chemical and physical characteristics of the product that influence the NIR spectrum affect the qualification. The qualification is used to determine several deviations in the process: moisture, particle size and non-homogeneity. This work presents a method for the qualification analysis of a pharmaceutical mixture using the standard software of the instrument and a new program (DISPLOT). This program allows the acquisition of the plot of the scaled distances with its sign vs the wavelength.
Quality Control Department, Laboratorios Almirall, S.A. Crta. Nacional II, Barcelona, Spain.
F
F
González
R
R
Pous
D004338:Drug Combinations; D004339:Drug Compounding / Q000592:standards*; D004345:Drug Industry / Q000592:standards; D010363:Pattern Recognition, Automated; D011786:Quality Control; D012984:Software; D013055:Spectrophotometry, Infrared
D004338:Drug Combinations