3-Aminobenzamide inhibition of protein kinase C at a cellular level.
3-Aminobenzamide, a known inhibitor of poly-(ADP-ribose)-polymerase has been found in the cell line U-937 to inhibit protein kinase C at the same concentration as poly-(ADP-ribose)-polymerase. 3-Aminobenzamide was not able, however, to inhibit the isolated enzyme. An indirect mechanism of protein kinase C inhibition is proposed.
Institut für Biochemie und Molekularbiologie, Universität Bern, Switzerland.
R
R
Ricciarelli
L
L
Palomba
O
O
Cantoni
A
A
Azzi
D001549:Benzamides / Q000494:pharmacology*; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D011493:Protein Kinase C / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D001549:Benzamides; D004791:Enzyme Inhibitors; D011994:Recombinant Proteins; C025160:3-aminobenzamide; D006861:Hydrogen Peroxide; D011493:Protein Kinase C; D013755:Tetradecanoylphorbol Acetate