Myocardial Epstein-Barr virus-associated cardiac smooth-muscle neoplasm arising in a cardiac transplant recipient.
Epstein-Barr virus-associated smooth muscle proliferations have been reported in immunosuppressed patients with acquired immunodeficiency syndrome and after organ transplantation. We report here a case of a histologically benign case arising in a 48-year-old male who had received immunosuppressive therapy 4 years earlier, after cardiac transplantation. In the necropsy performed for unrelated reasons, an incidental left intramyocardial tumor was discovered. The presence of Epstein-Barr virus was confirmed by EBER-1 in situ hybridization and polymerase chain reaction. To the best of our knowledge, this is the first case of an Epstein-Barr virus-associated smooth muscle proliferation arising in the heart after cardiac transplantation and should be added to the potential complications of this kind of procedure.
Anguita
J
J
Department of Hematology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Rico
M L
ML
Palomo
J
J
Muñoz
P
P
Preciado
V
V
Menárguez
J
J
D017544:Aortic Aneurysm, Abdominal / Q000473:pathology; D001019:Aortic Rupture / Q000473:pathology; D002455:Cell Division / Q000502:physiology*; D003324:Coronary Artery Disease / Q000473:pathology; D016027:Heart Transplantation / Q000473:pathology*; D006352:Heart Ventricles / Q000473:pathology; D006566:Herpesviridae Infections / Q000473:pathology*; D004854:Herpesvirus 4, Human; D006801:Humans; D008297:Male; D008875:Middle Aged; D009130:Muscle, Smooth / Q000473:pathology*; D014412:Tumor Virus Infections / Q000473:pathology*