The effect of triclabendazole (Fasinex) in children with fasciolosis.
Three children infected with Fasciola hepatica (FH) were treated with triclabendazole (TCZ; Fasinex). In the first two patients, firstly, albendazole (Andazole) was administered, but did not stop the excretion of FH eggs. To these two patients, TCZ was administered in a single oral dose of 10 mg/kg postprandially. Two month later, very few eggs were found in stool samples. So, the same dose of triclabendazole was secondly given to the patients. After this therapy. FH eggs have not been found in the repeated stool examinations for a follow up of one year. To the third patient, TCZ was administered in a single oral dose of 10 mg/kg together with food. This patient has remained free of complaints and stool samples were free from FH eggs for two months. In conclusion, TCZ may be used as a treatment of choice for human fasciolosis both in adults, and children.
Department of Microbiology and Clinical Microbiology, Medical School, Yäzüncu Yil University, Van/Turkey.
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Yilmaz
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Oner
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Akdeniz
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Arslan
D000980:Antiplatyhelmintic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005211:Fascioliasis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D000077682:Triclabendazole
D000980:Antiplatyhelmintic Agents; D001562:Benzimidazoles; D000077682:Triclabendazole