Sequence of the human CALM II calmodulin gene promoter region.
A clone containing a portion of the promoter region for the human bona fide CALM II gene was isolated using a human Promoter Finder DNA Walking Kit. This promoter region contains, putatively, a GC box (common in housekeeping genes), a CRE-binding site, a TATA like box and AGGGA sequences. The latter are reported to be present in genes for Ca2+ binding genes. This human promoter region exhibits overall 85% sequence identity to the corresponding region of the rat CALM II promoter but shows no identity to the corresponding region of the human CALM I or CALM III promoters.
Department of Biochemistry and Molecular Biology, Howard University Medical School, Washington, DC 20059, USA.
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JD
Karkera
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Friedberg
D000818:Animals; D001483:Base Sequence; D002147:Calmodulin / Q000235:genetics*; D016386:Chromosome Walking; D016384:Consensus Sequence; D017362:Cyclic AMP Response Element-Binding Protein / Q000235:genetics; D004285:Dogs; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic / Q000235:genetics*; D051381:Rats; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid; D016385:TATA Box
D002147:Calmodulin; D017362:Cyclic AMP Response Element-Binding Protein