A phylogenetic analysis of the cytochrome b and cytochrome c oxidase I genes supports an origin of mitochondria from within the Rickettsiaceae.
We have cloned and sequenced the genes encoding cytochrome b (cob) and cytochrome c oxidase subunit I (cox1) from Rickettsia prowazekii, a member of the alpha-proteobacteria. The phylogenetic analysis supports the hypothesis that mitochondria are derived from the alpha-proteobacteria and more specifically from within the Rickettsiaceae. We have estimated that the common ancestor of mitochondria and Rickettsiaceae dates back to more than 1500 million years ago.
Department of Molecular Biology, Uppsala University, Sweden.
T
T
Sicheritz-Pontén
C G
CG
Kurland
S G
SG
Andersson
D000596:Amino Acids; D001482:Base Composition; D003001:Cloning, Molecular; D003573:Cytochrome b Group / Q000235:genetics*; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D003576:Electron Transport Complex IV / Q000235:genetics*; D005798:Genes, Bacterial / Q000235:genetics; D008928:Mitochondria / Q000201:enzymology / Q000235:genetics*; D008969:Molecular Sequence Data; D010802:Phylogeny; D012283:Rickettsia prowazekii / Q000201:enzymology / Q000235:genetics; D012287:Rickettsiaceae / Q000201:enzymology / Q000235:genetics*; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA
D000596:Amino Acids; D003573:Cytochrome b Group; D004269:DNA, Bacterial; D003576:Electron Transport Complex IV