[Signal transductions by the MAP kinase cascades].
The classical mitogen-activated protein(MAP) kinase cascade is one of the central intracellular signaling pathways that play a crucial role in cell proliferation, cell differentiation, cell transformation, and many other cellular responses. Two novel MAP kinase cascades, the SAPK/JNK cascade and the p38/MPK2 cascade, were identified, and were shown to function in various stress responses and apoptotic processes. Intracellular distribution of classical MAP kinase kinase (MAPKK/MEK) is regulated by its nuclear export signal (NES) which may function to suppress malignant cell transformation. CRM1 protein has been identified as a receptor for leucine-rich NES. CRM1 binds to CAN/NUP214, one of nucleopore proteins, which has been suggested to be involved in myeloid leukemia. Thus, the nuclear export system may be by somehow related to cancer development.
Department of Biophysics, Graduate School of Science, Kyoto University.
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Gotoh
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Nishida
D000818:Animals; D001426:Bacterial Proteins; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000502:physiology*; D002352:Carrier Proteins / Q000378:metabolism; D002471:Cell Transformation, Neoplastic; D004720:Endonucleases / Q000378:metabolism; D006801:Humans; D028884:Karyopherins; D020929:Mitogen-Activated Protein Kinase Kinases; D011485:Protein Binding; D011494:Protein Kinases / Q000502:physiology; D018160:Receptors, Cytoplasmic and Nuclear; D015398:Signal Transduction; D000097606:Exportin 1 Protein
D001426:Bacterial Proteins; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D002352:Carrier Proteins; D004720:Endonucleases; D028884:Karyopherins; D020929:Mitogen-Activated Protein Kinase Kinases; D011494:Protein Kinases; D018160:Receptors, Cytoplasmic and Nuclear; D000097606:Exportin 1 Protein; C100898:nes protein, Staphylococcus aureus