Attachment but not penetration of bovine herpesvirus 1 is necessary to induce apoptosis in target cells.
Bovine herpesvirus 1 (BHV-1) induces apoptotic cell death in bovine peripheral blood mononuclear cells and B-lymphoma cells. Using a BHV-1 glycoprotein H null mutant, we have demonstrated that although penetration of BHV-1 is not required, attachment of BHV-1 viral particles is essential for the induction of apoptosis.
Hanon
E
E
Departments of Immunology/Vaccinology, Faculty of Veterinary Medicine, University of Liège, B-4000 Liège, Belgium. hanon@stat.fmv.ulg.ac.be
Meyer
G
G
Vanderplasschen
A
A
Dessy-Doizé
C
C
Thiry
E
E
Pastoret
P P
PP
D000818:Animals; D017209:Apoptosis; D002417:Cattle; D002460:Cell Line; D002478:Cells, Cultured; D053938:DNA Fragmentation; D017353:Gene Deletion; D006493:Heparin / Q000494:pharmacology; D007242:Herpesvirus 1, Bovine / Q000378:metabolism* / Q000502:physiology; D007963:Leukocytes, Mononuclear / Q000166:cytology; D014407:Tumor Cells, Cultured; D014764:Viral Proteins / Q000235:genetics / Q000502:physiology*
D014764:Viral Proteins; C046998:bovine herpesvirus type-1 glycoproteins; D006493:Heparin