Not just pretty eyes: Drosophila eye-colour mutations and lysosomal delivery.
Analysis of Drosophila eye-colour mutations has made seminal contributions to the fields of genetics and biochemistry. Recent findings suggest that a subset of eye-colour genes is crucial for vesicular transport of proteins to pigment granules, specialized lysosomes of eye-pigment cells. Thus, classical work describing more than 85 eye-colour mutations and their genetic interactions offers a remarkable, untapped resource for the genetic analysis of protein delivery to lysosomes.
Dept of Biology and Biochemistry, Mt Allison University, Sackville, NB, Canada. vlloyd@mta.ca.mani@u.arizona.edu
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D000818:Animals; D004330:Drosophila / Q000502:physiology*; D005127:Eye Color / Q000235:genetics*; D008247:Lysosomes / Q000502:physiology*; D009154:Mutation / Q000502:physiology; D017956:Photoreceptor Cells, Invertebrate / Q000502:physiology*