[Features of humoral antibacterial immunity in patients with HIV infections and AIDS].
The level of antibodies to some bacterial antigens, their affinity and relationship to the level of CD4+ T-lymphocytes in persons at different stages of HIV infection was studied. The study revealed that at early stages of the development of HIV infection a decrease in the levels of antibodies to Streptococcus pneumoniae protein somatic antigen in comparison with those in HIV-negative donors occurred. In the process of the development of HIV infection an increase in the level of Staphylococcus aureus peptidoglycan and some S.aureus antigenic determinants, as well as to S.pneumoniae protein somatic antigen, took place. Patients with HIV infection who had non-specific pulmonary diseases exhibited an increased level of antibodies to Branhamella catarrhalis complex ultrasonic antigen. In patients with HIV infection having an amount of CD4+ T-lymphocytes below 200/1 the level of antibodies to bacterial antigen was higher than in patients with an amount of CD4+ T-lymphocytes varying within 200-400/1. In addition, at all stages of HIV infection and in all kinds of its complications an increase in the titer of antibodies to N-acetylglycosoaminylmuramyl dipeptide, an antigenic determinant of peptidoglycan with immunostimulating and adjuvant activity.
Kulakov
A V
AV
Research Institute of Immunology, Moscow, Russia.
Pinegin
B V
BV
Karsonova
M I
MI
Simonova
A V
AV
Khaitov
R M
RM
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000328:Adult; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D001991:Bronchitis / Q000276:immunology / Q000382:microbiology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008171:Lung Diseases / Q000276:immunology / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D001936:Moraxella catarrhalis / Q000276:immunology; D013211:Staphylococcus aureus / Q000276:immunology; D013296:Streptococcus pneumoniae / Q000276:immunology; D017186:Titrimetry
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G