Infections caused by multiple strains of methicillin-resistant Staphylococcus aureus--a pressing epidemiological issue.
The genotype of methicillin-resistant Staphylococcus aureus (MRSA) strains isolated from several foci in the same patient was studied to identify the rate of infections caused by multiple MRSA strains during hospitalization. Twenty-one patients with MRSA bacteraemia and other specimens diagnosed between 1990-1994 were studied. Clinical data were retrospectively collected from the medical records. Genotyping of 113 MRSA isolates was performed by pulsed-field gel electrophoresis (PFGE), using the Gene Navigator System. More than one type of MRSA was detected from different foci in eight of 21 (38%) patients, and three types were identified in a single patient. Our results indicate that epidemiological investigations must be conducted carefully, especially in immunocompromised hosts with MRSA bacteraemia, as the probability of infection with multiple strains among these patients is relatively high.
Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
J
J
Wang
T
T
Sawai
K
K
Tomono
K
K
Yanagihara
Y
Y
Hirakata
J
J
Matsuda
C
C
Mochida
F
F
Iori
H
H
Koga
T
T
Tashiro
S
S
Kohno
D000328:Adult; D000368:Aged; D016470:Bacteremia / Q000453:epidemiology / Q000382:microbiology; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology*; D005260:Female; D005838:Genotype; D006785:Hospitals, University; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D016106:Methicillin Resistance / Q000235:genetics; D008875:Middle Aged; D010641:Phenotype; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000235:genetics / Q000302:isolation & purification