Kinetics of Chlamydia trachomatis clearance in patients with azithromycin, as assessed by first void urine testing by PCR and transcription-mediated amplification.
METHODS
Test-of-cure of 19 patients with Chlamydia trachomatis genital infection was assessed by daily collection of first void urine for 7 days just after treatment by azithromycin single-dose.


RESULTS
Detection by PCR and TMA of C. trachomatis showed a good correlation between both methods. The observation that post-therapy chlamydial nucleic acid detection is associated to bacterial clearance suggests that all the patients were cured.
Institut Alfred Fournier, French National Reference Center for Sexually Transmitted Diseases, Paris, France.
A
A
Bianchi
M
M
Bogard
G
G
Cessot
J M
JM
Bohbot
J E
JE
Malkin
J M
JM
Alonso
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017963:Azithromycin / Q000627:therapeutic use*; D002690:Chlamydia Infections / Q000188:drug therapy* / Q000382:microbiology / Q000652:urine; D002692:Chlamydia trachomatis; D004269:DNA, Bacterial / Q000652:urine; D005260:Female; D005500:Follow-Up Studies; D005784:Gene Amplification; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D014158:Transcription, Genetic
D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D017963:Azithromycin