An in vivo model to study the anti-malaric capacity of plant extracts.
An in vivo model to study the antimalaric effect of plant extracts is described. White mice (25-30 g body weight) are treated subcutaneously with 0.6 ml of the diluted extract starting seven days before P. berghei infection; treatment continues until death or for 30 days. Simultaneously 0.2 ml of the extract are applied per os starting three days before infection. In a test of the model, treated and non-treated animals differed in body weight, survival time, haematocrite, parasitemia development, and spleen or liver weight of recent dead or killed mice.
Chinchilla
M
M
Centro de Investigación en Enfermedades Tropicales (CIET), Facultad de Microbiología, Universidad de Costa Rica, Costa Rica.
Guerrero
O M
OM
Abarca
G
G
Barrios
M
M
Castro
O
O
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D008288:Malaria / Q000188:drug therapy*; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D010962:Plasmodium berghei / Q000187:drug effects*; D013997:Time Factors
D000962:Antimalarials; D010936:Plant Extracts