Elevated concentrations of eotaxin and interleukin-5 in human neurocysticercosis.
Symptomatic neurocysticercosis, a major cause of epilepsy worldwide, results from inflammation around Taenia solium larvae, but the mechanisms are unknown. Eotaxin, not previously reported in cases of human infection, and interleukin-5 (IL-5) but not IL-8 concentrations were elevated in patient serum, and IL-5 levels were also elevated in cerebrospinal fluid (CSF). Eosinophil-selective mediators may be involved in the pathogenesis of cysticercosis. IL-6 concentrations were also elevated in patient CSF, possibly indicative of an acute-phase response.
Department of Infectious Diseases, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom.
C A
CA
Evans
H H
HH
Garcia
A
A
Hartnell
R H
RH
Gilman
P J
PJ
Jose
M
M
Martinez
D G
DG
Remick
T J
TJ
Williams
J S
JS
Friedland
D000328:Adult; D000818:Animals; D054413:Chemokine CCL11; D019742:Chemokines, CC; D002631:Chemotactic Factors, Eosinophil / Q000378:metabolism*; D003551:Cysticercosis / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D016207:Cytokines / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D006801:Humans; D015848:Interleukin-5 / Q000378:metabolism*; D008875:Middle Aged; D013621:Taenia / Q000276:immunology*
C515456:CCL11 protein, human; D054413:Chemokine CCL11; D019742:Chemokines, CC; D002631:Chemotactic Factors, Eosinophil; D016207:Cytokines; D015848:Interleukin-5