A case of EBV-associated lymphoproliferative disease following high-dose therapy and CD34-purified autologous peripheral blood progenitor cell transplantation.
A fatal case of EBV-associated lymphoproliferative disorder arising after a CD34-selected autologous peripheral blood stem cell transplant is reported in a patient with multiple myeloma in first plateau phase. It is suggested that this is likely to be a consequence of the accessory cell depletion associated with the CD34+ cell purification and it is recommended that a source of autologous T cells is stored before transplantation to be used if a severe opportunistic infection or EBV lymphoma arises post-transplantation.
Department of Haematology, University College London Hospitals, UK.
A J
AJ
Peniket
A R
AR
Perry
C D
CD
Williams
A
A
MacMillan
M J
MJ
Watts
P G
PG
Isaacson
A H
AH
Goldstone
D C
DC
Linch
D018952:Antigens, CD34; D016465:Bone Marrow Purging; D020031:Epstein-Barr Virus Infections / Q000209:etiology*; D017809:Fatal Outcome; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008212:Lymphocyte Depletion; D017710:Lymphocyte Transfusion; D008232:Lymphoproliferative Disorders / Q000209:etiology*; D008875:Middle Aged; D009101:Multiple Myeloma / Q000628:therapy; D009894:Opportunistic Infections / Q000209:etiology*; D013601:T-Lymphocytes / Q000276:immunology; D019172:Transplantation Conditioning
D018952:Antigens, CD34