Predictive value of remnant-like particles cholesterol/high-density lipoprotein cholesterol ratio as a new indicator of coronary artery disease.
BACKGROUND
There is as yet no definite consensus on the predictive value of the various lipid profiles and fibrinolytic parameters that became available in clinical use recently for coronary artery disease.


METHODS
Levels of lipoprotein(a), high-density lipoprotein cholesterol (HDL-C), remnant-like particles cholesterol (RLP-C), tissue plasminogen activator (TPA), TPA inhibitor, antithrombin III, and protein C were measured in 124 patients who underwent diagnostic coronary angiograms.


RESULTS
Of these patients, 37 had no significant stenoses (group N) and 87 had significant stenoses (group S). There were no significant differences in patient characteristics between the two groups. HDL-C was significantly lower (p = 0.0071 ) and RLP-C was significantly higher (p = 0.0022) in group S. When a product and a ratio of each of two factors were calculated, RLP-C/HDL-C was demonstrated to be a highly significant predictor for coronary artery stenoses (p < 0.0001). There were also significant increases in RLP-C/HDL-C levels with increasing number of vessels involved (r = 0.359, p < 0.0001 ).


CONCLUSIONS
Our present study disclosed the predictive value of RLP-C/HDL-C ratio as a new indicator of coronary artery disease.
Division of Internal Medicine, Owase General Hospital, Mie, Japan.
H
H
Masuoka
K
K
Ishikura
S
S
Kamei
T
T
Obe
T
T
Seko
K
K
Okuda
S
S
Koyabu
K
K
Tsuneoka
T
T
Tamai
M
M
Sugawa
T
T
Nakano
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000990:Antithrombin III / Q000378:metabolism; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood*; D017023:Coronary Angiography; D003327:Coronary Disease / Q000097:blood / Q000175:diagnosis*; D005260:Female; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011486:Protein C / Q000378:metabolism; D012307:Risk Factors; D010959:Tissue Plasminogen Activator / Q000097:blood
D008076:Cholesterol, HDL; D017270:Lipoprotein(a); D011486:Protein C; D000990:Antithrombin III; D002784:Cholesterol; D010959:Tissue Plasminogen Activator