[The study of the interaction of antineoplastic drugs mitoxantrone and ametantrone with DNA using the analysis of changes in circular dichroism spectra].
The influence of the ionic strength and temperature of medium on the changes in the geometry of the double stranded DNA of different nucleotide content upon the formation of complexes with antitumor drugs mitoxantrone and ametantrone was investigated. It is shown that from circular dichroism spectra it is possible to determine the relative intensity of changes in the geometry of DNA double helix upon binding with the drugs investigated. The binding of one ametantrone molecule causes greater changes in the geometry of DNA double helix than the binding of mitoxantrone.
Babaian
Iu S
IuS
Yerevan State University, Armenia.
Sngrian
A E
AE
Kazarian
R S
RS
Avetisian
M G
MG
Sogomonian
L R
LR
Garibian
D V
DV
D000970:Antineoplastic Agents / Q000378:metabolism* / Q000494:pharmacology; D002942:Circular Dichroism; D004269:DNA, Bacterial / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D008837:Micrococcus; D008942:Mitoxantrone / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000494:pharmacology
D000970:Antineoplastic Agents; D004269:DNA, Bacterial; D008942:Mitoxantrone; C020182:ametantrone