Chemically induced analgesic nephropathy in the rat monitored by proton-electron double-resonance imaging (PEDRI).
Proton-electron double-resonance imaging (PEDRI) was used to assess renal function by monitoring the flow of the exogenous nitroxide free radical proxyl carboxylic acid (PCA) through normal and injured kidneys in the living rat. Kidney damage was induced by treatment with 2-bromoethylamine (BEA), which provides a well established model for human analgesic nephropathy. PCA clearance rates for liver, abdominal blood vessels, and renal tissues were determined from serial PEDRI images of normal rats (n = 6) and rats treated with BEA (n = 21). Different groups of BEA-treated animals were imaged on day 4 (n = 6), day 6 (n = 6), and day 9 (n = 9) after treatment. In BEA-treated rats, there was an increase in PCA half-life in all tissues studied. This increase was greatest in the kidney tissues and the effect progressed with time after treatment. The effect is probably due to BEA-induced damage to the tubules in the renal cortex and may not be related to the primary lesions in the renal medulla.
Department of Biomedical Physics and Bioengineering, University of Aberdeen, Foresterhill, Scotland.
I
I
Seimenis
M A
MA
Foster
D J
DJ
Lurie
J M
JM
Hutchison
P H
PH
Whiting
S
S
Payne
D000700:Analgesics / Q000633:toxicity*; D000818:Animals; D005021:Ethylamines / Q000633:toxicity*; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007677:Kidney Function Tests; D007681:Kidney Papillary Necrosis / Q000139:chemically induced*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D011522:Protons; D051381:Rats; D017208:Rats, Wistar; D012680:Sensitivity and Specificity
D000700:Analgesics; D005021:Ethylamines; D011522:Protons; C004504:2-bromoethylamine