[Effect of live tularemia vaccine on some parameters of immune and non-specific antitumor resistance in endometrial cancer patients during combined therapy and later].
The levels of T-system lymphocytes, macrophageal transformation of mononuclears and phagocytic activity of blood neutrophils were assayed in 194 patients with endometrial tumors, stage I-IV, (FIGO, 1988), 10-15 days after surgery, a subsequent course of telegammatherapy and 2-3 years after treatment. Ninety-seven patients of the study group were challenged by immunization with a live tularemia vaccine (LTV) 15-20 days before surgery, while the same number of controls were not. The study was randomized. Pre-operative LTV immunization showed an immunoprotective effect at all stages of combined treatment (surgery + telegammatherapy) given for endometrial carcinoma. Moreover, all said indices came back to normal in the study group 2-3 years after treatment. After surgery alone (standard uterine extirpation or with adnexa), controls with malignancies at the same stages revealed a significant decrease in the indices which fell further after radiotherapy. In the latter group, the indices came back to initial values which were below the norm.
V.A. Fanarjan Center for Cancer Research, Ministry of Health of the Republic of Armenia, Yerevan.
M A
MA
Movsesian
R T
RT
Adamian
D001428:Bacterial Vaccines / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D016889:Endometrial Neoplasms / Q000276:immunology* / Q000628:therapy*; D005260:Female; D006801:Humans; D016233:Immunotherapy, Active / Q000379:methods; D008264:Macrophages; D009504:Neutrophils; D010587:Phagocytosis; D013601:T-Lymphocytes; D013997:Time Factors; D016896:Treatment Outcome; D014406:Tularemia
D001428:Bacterial Vaccines