Liposome-DNA interaction: microcalorimetric study.
The authors applied differential scanning calorimetry (DSC) for studying the thermodynamic characteristics of DNA-liposome interactions. At the first stage, the melting curves of the 'order-disorder' thermal transition for lipid component and of the 'helix-coil' transition for DNA were obtained. At the second stage, the phase behavior of the DNA-lipid mixture as a function of both components (lipid/DNA ratio) was obtained. The liposome-DNA interaction was investigated comparing the melting curves of the pure components and the mixture.
Mrevlishvili
G M
GM
Department of Physics, Tbilisi State University, Georgia.
Kankia
B I
BI
Mdzinarashvili
T J
TJ
Brelidze
T I
TI
Khvedelidze
M M
MM
Metreveli
N O
NO
Razmadze
G Z
GZ
D002152:Calorimetry, Differential Scanning; D004247:DNA / Q000737:chemistry*; D004134:Dimyristoylphosphatidylcholine / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D013816:Thermodynamics
D008081:Liposomes; D004247:DNA; D004134:Dimyristoylphosphatidylcholine