Human carotid baroreflex during isometric lower arm contraction and ischemia.
Our aim was to determine the roles of somatomotor activation and muscle ischemia for the tachycardia and hypertension of isometric arm contraction. Carotid-cardiac and carotid-mean arterial pressure (MAP) baroreflex response curves were determined in 10 men during rest, during isometric arm contraction at 30% of maximum, and during postcontraction ischemia. Carotid distending pressure (CDP) was changed by applying pressure and suction in a neck chamber. Pressures ranged from +40 to -80 mmHg and were applied repeatedly for 15 s during the three conditions. Maximum slopes and ranges of the response curves did not differ among conditions. The heart rate (HR) curve was shifted to a 14 +/- 1.8 (mean +/- SE) beats/min higher HR and a 9 +/- 5.7 mmHg higher CDP during contraction and to a 14 +/- 5.9 mmHg higher CDP during postcontraction ischemia with no change of HR compared with rest. The MAP curve was shifted to a 20 +/- 2.8 mmHg higher MAP and to a 18 +/- 5.4 mmHg higher CDP during contraction, and the same shifts were recorded during postcontraction ischemia. We conclude that neither somatomotor activation nor muscle ischemia changes the sensitivity of arterial baroreflexes. The upward shift of the MAP response curve, with no shift of the HR response curve during postexercise ischemia, supports the notion of parallel pathways for MAP and HR regulation in which HR responses are entirely caused by somatomotor activation and the pressor response is mainly caused by muscle ischemia.
Spaak
J
J
Section of Environmental Physiology, Department of Physiology and Pharmacology, Karolinska Institutet, S-171 77 Stockholm, Sweden.
Sundblad
P
P
Linnarsson
D
D
D000328:Adult; D017704:Baroreflex / Q000502:physiology*; D001696:Biomechanical Phenomena; D001794:Blood Pressure; D002339:Carotid Arteries / Q000502:physiology*; D005542:Forearm; D006339:Heart Rate; D006801:Humans; D007511:Ischemia / Q000503:physiopathology*; D007537:Isometric Contraction / Q000502:physiology*; D008297:Male; D018482:Muscle, Skeletal / Q000098:blood supply*