[The action of the neurotoxin AF64A on the reactions of neuroticized rats].
The effects of intracerebroventricular administration of ethylholine aziridinum ion (AF64A) were studied in neuroticized male Wistar rats. The cholinotoxin was bilaterally injected in the dose of 3 nmol. AF64A produced a significant decrease in arterial pressure and activity of respiratory enzymes succinate dehydrogenase and NADH-dehydrogenase in hippocampus and motor cortex. Increase in the local blood flow in the hippocampus and motor cortex had a compensatory character.
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
M G
MG
Aĭrapetiants
I P
IP
Levshina
L V
LV
Nozdracheva
N N
NN
Shuĭkin
D000818:Animals; D001388:Aziridines / Q000008:administration & dosage / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002794:Choline / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D006624:Hippocampus / Q000098:blood supply / Q000187:drug effects / Q000201:enzymology; D007276:Injections, Intraventricular; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D009044:Motor Cortex / Q000098:blood supply / Q000187:drug effects / Q000201:enzymology; D009245:NADH Dehydrogenase / Q000187:drug effects; D009497:Neurotic Disorders / Q000209:etiology / Q000503:physiopathology*; D009498:Neurotoxins / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013385:Succinate Dehydrogenase / Q000187:drug effects; D013997:Time Factors
D001388:Aziridines; D009498:Neurotoxins; C044894:ethylcholine aziridinium; D013385:Succinate Dehydrogenase; D009245:NADH Dehydrogenase; D002794:Choline