The significance of keratinizing squamous cell histology in Chinese patients with nasopharyngeal carcinoma.
Six hundred and ninety-three Chinese patients with non-metastatic nasopharyngeal carcinoma (NPC) were treated at one institution under a uniform protocol between 1984 and 1989. The tumour histology of these patients was subjected to a standardized review and classified into two distinct groups of World Health Organization (WHO) type I (keratinizing squamous cell carcinoma) (n = 13) or WHO types II and III (non-keratinizing carcinoma and undifferentiated carcinoma) (n = 662). The differentiation between the two groups was uncertain in 18 patients. The patient characteristics and clinical outcome after a uniform treatment policy of the two groups were not statistically significantly different. The low incidence of WHO type I NPC may account for the lack of prognostic significance of this histological subtype in Chinese populations.
Chinese University of Hong Kong, Prince of Wales Hospital.
A T
AT
Chan
M L
ML
Teo
W Y
WY
Lee
W H
WH
Kwan
P H
PH
Choi
P J
PJ
Johnson
D000206:Actuarial Analysis; D001706:Biopsy; D002277:Carcinoma / Q000145:classification / Q000473:pathology* / Q000532:radiotherapy / Q000556:secondary; D002278:Carcinoma in Situ / Q000145:classification / Q000473:pathology / Q000532:radiotherapy / Q000556:secondary; D002294:Carcinoma, Squamous Cell / Q000145:classification / Q000473:pathology* / Q000532:radiotherapy / Q000556:secondary; D016001:Confidence Intervals; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D015994:Incidence; D007496:Iridium Radioisotopes / Q000627:therapeutic use; D007633:Keratins; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000145:classification / Q000473:pathology* / Q000532:radiotherapy; D009364:Neoplasm Recurrence, Local; D016017:Odds Ratio; D011379:Prognosis; D016016:Proportional Hazards Models; D019275:Radiopharmaceuticals / Q000627:therapeutic use; D011879:Radiotherapy Dosage; D015996:Survival Rate; D016896:Treatment Outcome; D014944:World Health Organization
D007496:Iridium Radioisotopes; D019275:Radiopharmaceuticals; D007633:Keratins