Condensed heterocyclic compounds: synthesis and antiinflammatory activity of novel thiazolo[3,2-alpha] pyrimidines.
In this study, thirty six new 2-benzylidene-7-methyl-3-oxo-5- phenyl-2,3-dihydro-5H-thiazolo[3,2-alpha]pyrimidine-6-carboxylic acid methyl esters were synthesized and characterized by spectral, crystallographic, and elemental analysis. The antiinflammatory activity of the compounds was tested by the carrageenan hind paw edema test. It was found that compound 6a having a 2-meth-oxyphenyl group at position 5 and a benzylidene group at position 2 was the most potent compound in this series. All the compounds that were tested for ulcer activity gave positive results.
Hacettepe Univ., Faculty of Pharmacy, Dept. of Pharmaceutical Chemistry, Ankara, Turkey.
B
B
Tozkoparan
M
M
Ertan
B
B
Krebs
M
M
Läge
P
P
Kelicen
R
R
Demirdamar
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000627:therapeutic use; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D006614:Hindlimb; D008297:Male; D051379:Mice; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000627:therapeutic use; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis* / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D006571:Heterocyclic Compounds; D011743:Pyrimidines; D013844:Thiazoles; D002351:Carrageenan