Prolactogenic effects of risperidone in male patients--a preliminary study.
This preliminary study describes a case of a male patient who developed gynaecomastia and sexual difficulties whilst taking risperidone for chronic paranoid schizophrenia. Laboratory tests showed raised prolactin levels and depressed testosterone levels which were reversed on cessation of medication. A small study was subsequently conducted on male psychotic patients to compare the prolactogenic effects of risperidone (n=14) with traditional antipsychotic medication (n=15). The results showed a greater but non-significant prolactogenic effect of risperidone.
Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75235-9070, USA.
R S
RS
Shiwach
T J
TJ
Carmody
D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D007172:Erectile Dysfunction / Q000097:blood / Q000139:chemically induced*; D006177:Gynecomastia / Q000097:blood / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood*; D018967:Risperidone / Q000009:adverse effects* / Q000627:therapeutic use; D012563:Schizophrenia, Paranoid / Q000097:blood / Q000188:drug therapy*; D013739:Testosterone / Q000097:blood
D014150:Antipsychotic Agents; D013739:Testosterone; D011388:Prolactin; D018967:Risperidone