Helical protein design.
It is now possible to design small proteins capable of folding into compact structures with well-packed cores. Given the present state of knowledge of protein folding and design, it is possible to extract a set of engineering guidelines that may assist in future de novo protein design.
Schafmeister
C E
CE
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Stroud
R M
RM
D011487:Protein Conformation; D015202:Protein Engineering / Q000379:methods* / Q000639:trends; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D011994:Recombinant Proteins / Q000737:chemistry / Q000378:metabolism
D011506:Proteins; D011994:Recombinant Proteins