Diazepam reduces ultrastructural changes induced by noise stress in rat adrenal gland.
Male rats were exposed to noise for 6 running hours and the effects of pretreatment with the benzodiazepine diazepam on the adrenal gland were evaluated. Ultrastructural examination showed that, after noise exposure, zona reticularis cells resulted the more affected, exhibiting areas of diluted cytoplasm, disarranged endoplasmic reticulum, membrane vestigia and some altered mitochondria; diluted cytoplasmic areas appeared in noradrenaline-storing cells, too. On the contrary, zona reticularis cells from diazepam-pretreated and noise-exposed rats resulted significantly less altered, as well as the noradrenaline-storing cells. The present findings indicate that diazepam is able to exert some protective action on adrenal gland alterations due to noise exposure.
Department of Human Morphology and Applied Biology, Faculty of Medicine, Pisa, Italy.
A
A
Pellegrini
P
P
Soldani
M
M
Gesi
P
P
Lenzi
G
G
Natale
F
F
Martini
R
R
Ruffoli
A
A
Paparelli
D000302:Adrenal Cortex / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D000311:Adrenal Glands / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure*; D000818:Animals; D003975:Diazepam / Q000494:pharmacology*; D008297:Male; D008854:Microscopy, Electron; D008928:Mitochondria / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D009622:Noise; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000473:pathology*; D015385:Zona Reticularis / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure
D003975:Diazepam