Protective immunity induced by live attenuated simian immunodeficiency virus.
Lack of information on the mechanisms of protective immunity to AIDS virus infection represents a major obstacle to the development of a rational strategy for an effective HIV vaccine. In macaques, immunization with live attenuated simian immunodeficiency viruses has induced the most potent protective immunity and continued study promises a better understanding of the nature of protective immune responses. Recent evidence supports involvement of both cytotoxic T lymphocytes and neutralizing antibodies in protective immunity against infection by simian immunodeficiency virus, but more detailed studies are needed to document their relative importance.
Division of Immunology, New England Regional Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA. pjohnson@warren.med.harvard.edu
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D000818:Animals; D000917:Antibody Formation; D015693:Gene Products, nef; D006801:Humans; D007111:Immunity, Cellular; D008251:Macaca; D016296:Mutagenesis; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000517:prevention & control*; D015302:Simian Immunodeficiency Virus / Q000235:genetics / Q000276:immunology*; D013242:Sterilization; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000276:immunology; D014762:Viral Interference; D014765:Viral Vaccines / Q000276:immunology*
D015693:Gene Products, nef; D014613:Vaccines, Attenuated; D014765:Viral Vaccines