[Effect of the proteolytic substance morikrase on the status of scar tissue under in vitro conditions].
Proteolytical preparation moricrasa was isolated from hepatopancreas of Paralithodes camtshatic. Moricrasa and its fractions were used for lysis of cicatricial tissue under in vitro conditions. It was found that moricrasa in concentrations 0.5 mg/ml and 2 mg/ml lysed the cicatrix during 72 and 14-16 hours, respectively. The fraction consisted of collagenolytic proteinase PC and trypsin revealed maximal activity of fraction of moricrasa was absent.
Liutova
L V
LV
School of Biology, M.V. Lomonosov Moscow State University.
Karabasova
M A
MA
Andreenko
G V
GV
Rudenskaia
G N
GN
Isaev
V A
VA
Brusov
A B
AB
D000818:Animals; D003386:Brachyura / Q000737:chemistry; D002921:Cicatrix / Q000378:metabolism*; D003094:Collagen / Q000378:metabolism; D010450:Endopeptidases / Q000302:isolation & purification / Q000494:pharmacology*; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D006868:Hydrolysis; D009097:Multienzyme Complexes / Q000302:isolation & purification / Q000494:pharmacology*
D005343:Fibrinolytic Agents; D009097:Multienzyme Complexes; D003094:Collagen; D010450:Endopeptidases; C089174:morikrase