Human placental Fc receptors and the trapping of immune complexes.
Monomeric maternal antibodies are transmitted to the fetus, but most immune complexes are trapped in the placental stroma. The receptors responsible for trapping immune complexes appear to be Fc gamma RIa, Fc gamma RIIa, and Fc gamma RIIIa on stromal macrophages, and Fc gamma RII on fetal capillary endothelial cells.
Rosenstiel Center for Basic Biomedical Sciences, W.M. Keck Institute for Cellular Visualization, Brandeis University, Waltham, MA 02254-9110, USA. simister@hydra.rose.brandeis.edu
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Simister
D000936:Antigen-Antibody Complex / Q000276:immunology / Q000378:metabolism*; D005260:Female; D006801:Humans; D007112:Immunity, Maternally-Acquired / Q000276:immunology*; D010920:Placenta / Q000276:immunology / Q000378:metabolism / Q000648:ultrastructure*; D011247:Pregnancy; D011961:Receptors, Fc / Q000276:immunology / Q000378:metabolism*
D000936:Antigen-Antibody Complex; D011961:Receptors, Fc