FTY720 inhibits the mRNA expression of intragraft cytotoxic molecules, leading to cardiac allograft survival.
Second Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
H
H
Nakajima
E
E
Sun
N
N
Mizuta
I
I
Fujiwara
T
T
Oka
D000818:Animals; D017931:DNA Primers; D000068876:Fingolimod Hydrochloride; D006085:Graft Survival / Q000187:drug effects / Q000502:physiology*; D053804:Granzymes; D016027:Heart Transplantation / Q000276:immunology / Q000502:physiology*; D007166:Immunosuppressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D008562:Membrane Glycoproteins / Q000235:genetics*; D054353:Perforin; D016133:Polymerase Chain Reaction; D052899:Pore Forming Cytotoxic Proteins; D011409:Propylene Glycols / Q000494:pharmacology / Q000627:therapeutic use*; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D012697:Serine Endopeptidases / Q000235:genetics*; D013110:Sphingosine / Q000031:analogs & derivatives; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014158:Transcription, Genetic / Q000187:drug effects*; D014184:Transplantation, Homologous
D017931:DNA Primers; D007166:Immunosuppressive Agents; D008562:Membrane Glycoproteins; D052899:Pore Forming Cytotoxic Proteins; D011409:Propylene Glycols; D012333:RNA, Messenger; D054353:Perforin; D053804:Granzymes; C509215:Gzmb protein, rat; D012697:Serine Endopeptidases; D000068876:Fingolimod Hydrochloride; D013110:Sphingosine