Failure to replicate a protective effect of allele 2 of NACP/alpha-synuclein polymorphism in Alzheimer's disease: an association study.
Recently, a dinucleotide repeat polymorphism was identified in the promoter of the nonamyloid component of plaques (NACP) gene, and it was shown that the NACP allele 2 was significantly associated with healthy elderly control individuals with at least one apolipoprotein E epsilon4 allele, suggesting a protective role for this allele in Alzheimer's disease. We genotyped the same NACP polymorphism in a comparable number of individuals diagnosed with dementia of the Alzheimer's type and in healthy, elderly controls. In our analysis, however, no protective effect for NACP allele 2, or any of the other NACP alleles, was observed.
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
N E
NE
Hellman
E A
EA
Grant
A M
AM
Goate
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D000682:Amyloid / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D001483:Base Sequence; D016009:Chi-Square Distribution; D018900:Dinucleotide Repeats; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D016017:Odds Ratio; D010750:Phosphoproteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D011498:Protein Precursors / Q000235:genetics*; D012016:Reference Values; D012307:Risk Factors; D051843:Synucleins
D000682:Amyloid; D001057:Apolipoproteins E; D009419:Nerve Tissue Proteins; D010750:Phosphoproteins; D011498:Protein Precursors; D051843:Synucleins