[Level of monoamines during hypobaric hypoxia and protective effect of pyrazidol].
The effects of single acute hypoxia (9000 m above the sea level, 3h) and intermittent hypoxia (5000 m 4 h daily during 3 and 10 days) were studied. Acute hypoxia was characterized by the increase in the content of brain serotonin, dopamine and norepinephrine accompanied by a decrease of deaminated product. The increase of monoamine contents in hypothalamus and adrenals during initial stage caused to considerable extent by their deamination and the monoamine decrease under 10-day hypoxia were typical for intermittent hypoxia. The administration of MAO a inhibitor pyrazidol promoted the increase in brain serotonin content, normalized brain catecholamine contents and demonstrated positive effect on the animal state.
Goroshinskaia
I A
IA
Rostov Research Oncology Institute, Russia.
Neskubina
I V
IV
D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002227:Carbazoles / Q000494:pharmacology*; D003641:Deamination; D000860:Hypoxia / Q000378:metabolism*; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D051381:Rats
D015306:Biogenic Monoamines; D002227:Carbazoles; D008996:Monoamine Oxidase Inhibitors; C009830:pirlindole