Serum concentrations of laminin P1 and aminoterminal propeptide of type III procollagen in sickle cell disease.
We determined serum levels of laminin and aminoterminal propeptide of type III procollagen (PIIINP) in 20 patients with sickle cell hemoglobinopathies. Elevated levels of soluble laminin and PIIINP were observed in the patients--1.5 +/- 0.3 U/ml (mean +/- SD) (range 1.1-1.9 U/ml) and 0.90 +/- 0.2 U/ml (range 0.6-1.4 U/ml), respectively, compared to normal controls, 1.3 +/- 0.1 U/ml (range 1.2-1.4 U/ml) for laminin and 0.7 +/- 0.1 U/ml (range 0.6-0.9 U/ml) for PIIINP. The serum laminin and PIIINP were significantly elevated (p < 0.02 and p < 0.001, respectively, in patients with sickle cell hemoglobinopathies). There was no correlation between serum laminin and PIIINP levels in the patient group. The study indicates that aminoterminal propeptide of type III procollagen and laminin can be utilized as valuable non-invasive markers of possible alterations in extracellular matrix in bone marrow, spleen, kidney or other tissues in sickle cell hemoglobinopathies.
Department of Chemical Pathology, College of Medical Sciences, University of Calabar, Nigeria.
D M
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Bolarin
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Swerdlow
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AM
Wallace
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Littsey
D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood*; D015415:Biomarkers; D003094:Collagen / Q000097:blood; D005260:Female; D006801:Humans; D007797:Laminin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood*; D011347:Procollagen / Q000097:blood*
D015415:Biomarkers; D007797:Laminin; D010446:Peptide Fragments; D011347:Procollagen; C055716:laminin P1; D003094:Collagen