Quantitative 1H MRI and MRS microscopy of individual V79 lung tumor spheroids.
In this Communication 1H MRI and MRS microscopy experiments of individual V79 lung tumor spheroids with diameters between 550 and 650 micrometer are reported. The results have been used to determine the T1, T2, and D values as well as the concentrations of water, total choline, creatine/phosphocreatine, and mobile lipids in the viable rims and in the necrotic centers.
Pacific Northwest National Laboratory, Richland, Washington, 99352, USA.
K R
KR
Minard
X
X
Guo
R A
RA
Wind
D000818:Animals; D002794:Choline / Q000032:analysis; D003401:Creatine / Q000032:analysis; D006224:Cricetinae; D003412:Cricetulus; D008055:Lipids / Q000032:analysis; D008175:Lung Neoplasms / Q000737:chemistry* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008853:Microscopy; D010725:Phosphocreatine / Q000032:analysis; D018874:Spheroids, Cellular / Q000737:chemistry* / Q000473:pathology; D014407:Tumor Cells, Cultured / Q000737:chemistry / Q000473:pathology; D014867:Water / Q000032:analysis
D008055:Lipids; D010725:Phosphocreatine; D014867:Water; D003401:Creatine; D002794:Choline