p59OASL, a 2'-5' oligoadenylate synthetase like protein: a novel human gene related to the 2'-5' oligoadenylate synthetase family.
The 2'-5' oligoadenylate synthetases form a well conserved family of interferon induced proteins, presumably present throughout the mammalian class. Using the Expressed Sequence Tag databases, we have identified a novel member of this family. This protein, which we named p59 2'-5' oligoadenylate synthetase-like protein (p59OASL), shares a highly conserved N-terminal domain with the known forms of 2'-5' oligoadenylate synthetases, but differs completely in its C-terminal part. The C-terminus of p59OASL is formed of two domains of ubiquitin-like sequences. Here we present the characterisation of a full-length cDNA clone, the genomic sequence and the expression pattern of this gene. We have addressed the evolution of the 2'-5' oligoadenylate synthetase gene family, in the light of both this new member and new 2'-5' oligoadenylate synthetase sequence data from other species, which have recently appeared in the databases.
Department of Molecular and Structural Biology, University of Aarhus, C. F. Mollers allé Building 130, DK-8000 Aarhus C, Denmark and Human Genome Sciences Inc., 9410 Key West Avenue, Rockville, MD 20850, USA.
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Hartmann
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Olsen
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Widder
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Jorgensen
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Justesen
D015088:2',5'-Oligoadenylate Synthetase / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics*; D000595:Amino Acid Sequence; D000818:Animals; D002645:Chickens; D003001:Cloning, Molecular; D016384:Consensus Sequence; D017124:Conserved Sequence; D016208:Databases, Factual; D019143:Evolution, Molecular; D005091:Exons; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D009928:Organ Specificity; D010802:Phylogeny; D051381:Rats; D011994:Recombinant Proteins / Q000096:biosynthesis; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D013552:Swine; D014452:Ubiquitins / Q000737:chemistry
D011994:Recombinant Proteins; D014452:Ubiquitins; C115020:OASL protein, human; D015088:2',5'-Oligoadenylate Synthetase