A discrimination study of human core-promoters.
A core-promoter, approximately from -60 bp upstream to +40 bp downstream of a RNA polymerase (RNAP) II transcription start site (TSS), binds to the preinitiation complex (PIC) and determine the position of TSS. Using position-specific k-tuple feature variables, a quadratic discriminant analysis (QDA) method is shown to be very effective in identifying human core-promoters.
Zhang
M Q
MQ
Cold Spring Harbor Laboratory, NY 11724, USA.
D001483:Base Sequence; D001665:Binding Sites; D019295:Computational Biology / Q000379:methods*; D016002:Discriminant Analysis; D006801:Humans; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D012319:RNA Polymerase II / Q000235:genetics* / Q000378:metabolism*; D015203:Reproducibility of Results; D012984:Software; D016385:TATA Box; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic
D014157:Transcription Factors; D012319:RNA Polymerase II