Deficient sensorimotor gating following seizures in amygdala-kindled rats.
BACKGROUND
Human patients with limbic epilepsy may develop a psychosis. We combined animal models for epileptogenesis and schizophrenia to investigate possible mechanisms underlying the occurrence of psychoses in epileptics. Since the dysfunction of sensorimotor gating is the basis of some psychotic symptoms, we tested if epileptogenesis or acute seizures influence sensorimotor gating in rats, measured as prepulse inhibition (PPI) of the acoustic startle response (ASR). PPI is the reduction of the ASR that is observed when a startling pulse is preceded by a nonstartling prepulse. Reduced PPI was found in schizophrenics and in rats under certain conditions.


METHODS
We investigated the effects on PPI of different models of limbic epileptogenesis (repeated stimulation of the basolateral amygdala, treatment with pentylenetetrazole, injection of kainate).


RESULTS
PPI was normal in chronic epileptic rats 1 week after the last generalized seizure. Impaired PPI was found in amygdala-kindled rats 10 min after seizures. The ASR amplitude in the absence of prepulses was increased in kainate-treated rats, but not in the other groups.


CONCLUSIONS
Chemical epileptogenesis or repeated stimulation of the amygdala per se did not disrupt sensorimotor gating, but the recent occurrence of seizures in amygdala-kindled rats compromised sensorimotor gating in a way compatible with psychotic states in humans.
Koch
M
M
Universität Tübingen, Germany.
Ebert
U
U
D000161:Acoustic Stimulation; D000679:Amygdala; D000704:Analysis of Variance; D000818:Animals; D003463:Cues; D004195:Disease Models, Animal; D004558:Electric Stimulation; D004833:Epilepsy, Temporal Lobe / Q000150:complications / Q000503:physiopathology*; D005260:Female; D007266:Inhibition, Psychological; D007608:Kainic Acid; D007696:Kindling, Neurologic / Q000502:physiology*; D010433:Pentylenetetrazole; D051381:Rats; D017208:Rats, Wistar; D013216:Reflex, Startle / Q000502:physiology*; D012559:Schizophrenia / Q000150:complications / Q000503:physiopathology*; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology
D007608:Kainic Acid; D010433:Pentylenetetrazole