Antibody responses in humans against coli surface antigen 6 of enterotoxigenic Escherichia coli.
Enterotoxigenic Escherichia coli (ETEC) strains expressing only coli surface antigen 6 (CS6) have previously been isolated from patients with diarrhea, but the immunogenicity of CS6 has not been established in humans. We have detected CS6-specific immunoglobulin A responses in the feces and blood of patients convalescing from natural ETEC disease and of volunteers given an oral ETEC vaccine.
Helander
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A
Department of Medical Microbiology and Immunology, Göteborg University, Göteborg, Sweden. anna.helander@microbio.gu.se
Wennerås
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C
Qadri
F
F
Svennerholm
A M
AM
D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis*; D000942:Antigens, Bacterial / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology*; D001426:Bacterial Proteins / Q000276:immunology*; D003967:Diarrhea / Q000276:immunology / Q000382:microbiology; D004797:Enzyme-Linked Immunosorbent Assay; D004926:Escherichia coli / Q000276:immunology*; D004927:Escherichia coli Infections / Q000276:immunology; D029968:Escherichia coli Proteins; D006801:Humans; D015151:Immunoblotting; D007070:Immunoglobulin A / Q000032:analysis*
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D000954:Antigens, Surface; D001426:Bacterial Proteins; C098406:CS6 antigen, E coli; D029968:Escherichia coli Proteins; D007070:Immunoglobulin A