Central depressant effects of reticuline extracted from Ocotea duckei in rats and mice.
Neuropharmacological studies were carried out with reticuline, a benzylisoquinoline alkaloid, isolated from Ocotea duckei Vattimo. It was found that reticuline (50-100 mg/kg i.p.) produced alteration of behaviour pattern, prolongation of pentobarbital-induced sleep, reduction in motor coordination and D-amphetamine-induced hypermotility and suppression of the conditioned avoidance response. These observations suggest that reticuline possesses potent central nervous system depressant action.
Laboratório de Tecnologia Farmacêutica e Departamento de Fisiologia e Patologia, Universidade Federal da Paraiba, João Pessoa, Brazil.
L C
LC
Morais
J M
JM
Barbosa-Filho
R N
RN
Almeida
D000470:Alkaloids / Q000008:administration & dosage / Q000494:pharmacology*; D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D044182:Benzylisoquinolines; D002492:Central Nervous System Depressants / Q000008:administration & dosage / Q000494:pharmacology*; D018492:Dopamine Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D007546:Isoquinolines / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010424:Pentobarbital / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012890:Sleep / Q000187:drug effects
D000470:Alkaloids; D044182:Benzylisoquinolines; D002492:Central Nervous System Depressants; D018492:Dopamine Antagonists; D007546:Isoquinolines; D010936:Plant Extracts; D000661:Amphetamine; D010424:Pentobarbital; C003298:reticuline