A possible association of alpha1-antitrypsin deficiency with the periodontal condition in adults.
Alpha1-antitrypsin (alpha1AT) is a serum inhibitor of several neutrophil-derived proteolytic enzymes, the serine proteinases. In certain individuals, a deficiency of this enzyme inhibitor is present, whereby only 10 to 20% of the normal concentration is present in the circulation. The purpose of this study was to evaluate the influence of this alpha1AT deficiency on the periodontal condition in a case control study. 10 patients aged 20-50 years with a mean age of 32 and showing a deficiency of alpha1AT were randomly selected from a national data bank, which contains persons known to be affected with the alpha1AT deficiency state. Control subjects were matched for age, gender and socio-economic status. Full periodontal charting on all subjects was performed on 6 sites per tooth, including probing attachment level, probing depth, bleeding on probing and a plaque score. Analysis of the data revealed no differences with regard to attachment loss between the two groups. The deficiency group showed 9.3% pockets > or =5 mm and the matched control group 5.9%. When these results were covariated with plaque scores, the deficiency group appeared to have a higher number of sites with probing depths > or =5 mm.
Department of Periodontology, College of Dental Science, Medical Faculty University of Nijmegen, The Netherlands. s.j.fokkema@amc.uva.nl
S J
SJ
Fokkema
M F
MF
Timmerman
F A
FA
van der Weijden
G N
GN
Wolffe
H H
HH
Renggli
D000328:Adult; D016022:Case-Control Studies; D003774:Dental Plaque Index; D005260:Female; D005884:Gingival Hemorrhage / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000209:etiology; D010510:Periodontal Diseases / Q000209:etiology*; D010514:Periodontal Pocket / Q000209:etiology; D010518:Periodontitis / Q000209:etiology; D010641:Phenotype; D015842:Serine Proteinase Inhibitors / Q000097:blood / Q000502:physiology; D012923:Social Class; D000515:alpha 1-Antitrypsin / Q000032:analysis / Q000502:physiology; D019896:alpha 1-Antitrypsin Deficiency / Q000150:complications*
D015842:Serine Proteinase Inhibitors; D000515:alpha 1-Antitrypsin