Hormone replacement modifies cholecystokinin-induced changes in sucrose palatability in ovariectomized rats.
The taste reactivity test was used to examine the effect of CCK-octapeptide (CCK-8) on the palatability of a sucrose solution in ovariectomized rats either receiving hormonal replacement (estradiol and progesterone; OVX + HRT), or treated with vehicle only (OVX + VEH). Statistical analyses revealed that the OVX + HRT rats treated with CCK-8 exhibited a robust decrease in ingestive responses, and an increase in aversive responses and passive drips to the intraoral sucrose infusions, relative to treatment with the NaCl vehicle. In contrast, a weak effect of CCK-8 on ingestive responses, no significant effect on the frequency of aversive responses, and a reduced effect on passive drips was observed in the OVX + VEH rats. These results show that CCK-8 modifies sucrose palatability, and that this effect is modulated by gonadal hormone levels.
Neuroscience Program, University of Western Ontario, Canada. sclarke@mach1.wlu.ca
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D000818:Animals; D001066:Appetite / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004347:Drug Interactions; D004435:Eating / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D010052:Ovariectomy; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D012844:Sincalide / Q000494:pharmacology*; D013395:Sucrose; D013649:Taste / Q000187:drug effects*
D011374:Progesterone; D004958:Estradiol; D013395:Sucrose; D012844:Sincalide