[The effect of selenium and vitamin E on the healing process of experimental corneal lesions in the eye of the rabbit].
OBJECTIVE
Evaluation of antioxidants: selenium and vitamin E efficacy in the treatment of experimental corneal lesion.


METHODS
Solution of selenium in 0.9% NaCl, concentration 0.01 g/L, to which vitamin E was added to obtain suspension of 2.5 g/L was used in 9 rabbits. The cornea was damaged by removing the epithelium from the central area of 7 mm diameter. To the right eye selenium solution with vitamin E was instilled.


RESULTS
In two eyes in which antioxidants were used evident prompt healing of corneal ulceration was noticed. Mean lesion diameter in eyes treated with antioxidants was: on 1st day 5.44 mm, in 2nd day 1.61 mm and on the 3rd day 0.33 mm. In control eyes diameters were: 6.67 mm, 2.28 mm and 0.56 mm, respectively.


CONCLUSIONS
Solution used in our study was tolerated very well. Faster healing process was noticed in eyes where antioxidants were used.
Sieradzki
E
E
Zakładu Farmacji Aptecznej Studium Farmaceutycznego, Centrum Medycznego Kształcenia Podyplomowego w Bydgoszczy.
Olejarz
E
E
Strauss
K
K
Marzec
A
A
Mieszkowska
M
M
Kałuzny
J
J
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D003315:Cornea / Q000187:drug effects*; D065306:Corneal Injuries; D003320:Corneal Ulcer / Q000188:drug therapy; D004359:Drug Therapy, Combination; D005131:Eye Injuries / Q000188:drug therapy; D007322:Instillation, Drug; D011817:Rabbits; D012643:Selenium / Q000008:administration & dosage*; D014810:Vitamin E / Q000008:administration & dosage*; D014945:Wound Healing / Q000187:drug effects*
D000975:Antioxidants; D014810:Vitamin E; D012643:Selenium