[Effect of a chloride channel inhibitor and chloride-free medium on choriogonin-induced cAMP formation by Xenopus laevis follicles].
The inhibitor of chloride channels DIDS (10 microM) decreased and a chloride-free medium increased the cAMP level in the Xenopus laevis follicles stimulated by human chorionic gonadotropin. Also, DIDS inhibited while the chloride-free medium stimulated maturation of the follicle-enclosed oocytes.
Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia.
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Skoblina
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Khukhtaniemi
D017878:4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid / Q000494:pharmacology*; D000818:Animals; D018118:Chloride Channels / Q000037:antagonists & inhibitors*; D002712:Chlorides / Q000494:pharmacology*; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D003470:Culture Media; D000242:Cyclic AMP / Q000096:biosynthesis*; D005260:Female; D006080:Ovarian Follicle / Q000187:drug effects* / Q000378:metabolism; D014982:Xenopus laevis
D018118:Chloride Channels; D002712:Chlorides; D006063:Chorionic Gonadotropin; D003470:Culture Media; D000242:Cyclic AMP; D017878:4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid