The relationship between substance use disorders, impulse control disorders, and pathological aggression.
The authors examine the relationship between substance use disorders, impulse control disorders (ICDs), and pathological aggression. Phenomenologic evidence, neurobiologic evidence, and comorbidity data, as well as evidence from the pharmacotherapy of aggression and impulse control and substance use disorders, suggest links between substance use, impulsivity, and pathologic aggression. There also is evidence suggesting that dysfunction in common neurotransmitter systems, particularly the serotonin and GABAergic systems, may be involved in both disorders. Serotonergic agents have been explored in the treatment of ICDs, pathological aggression, and substance use disorders. Mood-stabilizing anticonvulsant have GABAergic activity, have received preliminary exploration in the treatment of ICDs and aggression in a number of psychiatric disorders. There is also evidence that these agents may be useful in subgroups of individuals with substance use disorders.
Medical University of South Carolina, Department of Psychiatry, Charleston 29425, USA.
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Brady
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Myrick
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McElroy
D000374:Aggression / Q000187:drug effects*; D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000175:diagnosis / Q000523:psychology / Q000534:rehabilitation*; D004359:Drug Therapy, Combination; D018682:GABA Agents / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000523:psychology / Q000534:rehabilitation*; D016896:Treatment Outcome
D000927:Anticonvulsants; D018682:GABA Agents