Acute severe asthma treated by mechanical ventilation: a comparison of the changing characteristics over a 17 yr period.
Recorded cases of asthma have increased in recent years. It is unclear, however, whether this apparent increase in prevalence is accompanied by an increase in severity of the disorder. One potential measure of asthma severity is the requirement for mechanical ventilation. This paper examines those patients ventilated for severe asthma in a district general hospital over a 17 yr period. Since the methods used to assess asthma attacks and the criteria for instituting mechanical ventilation in this hospital did not alter between 1973 and 1992 (Jones criteria), it was possible to compare directly characteristics of all ventilated patients during the study period. The comparison showed that there was a significant increase between the two study periods in the number of patients who required mechanical ventilation. Moreover, in the more recent period both the subjective speed of onset of the asthma attack and the objective time between admission and ventilation were significantly shorter. However, despite this increase in asthma severity the mortality and morbidity in the more recent study period were lower. Overall the results of this study support the view that, in the population served by our district general hospital, asthma has increased in severity. This increased severity is indicated by an increase in the number of patients requiring mechanical ventilation and in the rapidity with which attacks evolved. However, for patients in whom ventilation was required, improved care has lowered both morbidity and mortality.
Department of Medicine, Whiston Hospital, Prescot, Merseyside, U.K.
S E
SE
Kearney
D R
DR
Graham
S T
ST
Atherton
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000453:epidemiology* / Q000503:physiopathology / Q000628:therapy*; D018893:Bronchoalveolar Lavage; D001999:Bronchoscopy; D016208:Databases, Factual; D005260:Female; D005500:Follow-Up Studies; D006767:Hospitals, District; D006769:Hospitals, General; D006801:Humans; D008168:Lung / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D018579:Patient Selection; D010366:Peak Expiratory Flow Rate; D015995:Prevalence; D012121:Respiration, Artificial