Effect of sodium methyl arsinate and imidocarb dipropionate antiprotozoal drugs on the pharmacokinetic of gentamicin in equines.
The pharmacokinetic behaviour of gentamicin sulphate (3.4 mg/kg bwt) was studied following its intramuscular injection to a group of horses and to another group of horses premedicated with sodium methyl arsinate (2 mg/kg bwt) or imidocarb dipropionate (4.8 mg/kg bwt). Considerable differences were observed in the pharmacokinetics of gentamicin in pre-medicated horses and in horses which had received the antibiotic alone. Peak serum concentration of gentamicin (9.85 +/- 0.05 and 11.15 +/- 0.15 micrograms/ml) were attained within 1.45 +/- 0.05 and 0.92 +/- 0.04 h in arsinate and imidocarb-medicated horses, respectively, but reached a level of 9.18 +/- 0.07 micrograms/ml at 1.87 +/- 0.12 h in non-medicated animals. Gentamicin elimination half-life (+/- 0.5(el)) was faster in arsinate (7.82 +/- 0.31 h) and imidocarb (6.12 +/- 0.14 h) pre-medicated horses than in non medicated horses (9.88 +/- 0.19 h). In addition, the interval between doses (lbd) necessary to maintain a therapeutic level were shorter in the pre-medicated animals. In summary, the hypothesis that the pharmacokinetics of gentamicin are altered by concomitant therapy with antiprotozoal drugs was confirmed by this study.
Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Egypt.
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GA
Soliman
D000818:Animals; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics*; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D001152:Arsenicals / Q000494:pharmacology*; D004347:Drug Interactions; D005839:Gentamicins / Q000097:blood / Q000493:pharmacokinetics*; D006736:Horses; D007095:Imidocarb / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D008657:Metabolic Clearance Rate
D000900:Anti-Bacterial Agents; D000981:Antiprotozoal Agents; D001152:Arsenicals; D005839:Gentamicins; D007095:Imidocarb; C020300:monomethylarsonic acid; C031719:imidocarb dipropionate