Impact of Sandimmune, Neoral, and Prograf on rejection incidence and renal function in primary liver transplant recipients.
Following primary liver transplantation, immunosuppressive efficacy of Neoral and Prograf was similar and superior to that of Sandimmune. Rejection incidence was statistically increased with Sandimmune therapy. Incidence of hypertension, posttransplant diabetes mellitus, and infectious complications was not statistically different. Although early compromise in renal function was associated with Sandimmune, Neoral, and Prograf immunosuppression, no progressive renal dysfunction was identified.
Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37232-4750, USA.
D
D
Van Buren
J
J
Payne
S
S
Geevarghese
R
R
MacDonell
W
W
Chapman
J K
JK
Wright
J H
JH
Helderman
R
R
Richie
C W
CW
Pinson
D000328:Adult; D000704:Analysis of Variance; D001379:Azathioprine / Q000627:therapeutic use; D003141:Communicable Diseases / Q000453:epidemiology; D003404:Creatinine / Q000097:blood; D016572:Cyclosporine / Q000009:adverse effects / Q000627:therapeutic use*; D003920:Diabetes Mellitus / Q000453:epidemiology; D004359:Drug Therapy, Combination; D006084:Graft Rejection / Q000453:epidemiology*; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D015994:Incidence; D007677:Kidney Function Tests; D016031:Liver Transplantation / Q000276:immunology* / Q000502:physiology; D008776:Methylprednisolone Hemisuccinate / Q000627:therapeutic use; D011183:Postoperative Complications / Q000453:epidemiology*; D012044:Regression Analysis; D012189:Retrospective Studies; D016559:Tacrolimus / Q000009:adverse effects / Q000627:therapeutic use*
D007166:Immunosuppressive Agents; D008776:Methylprednisolone Hemisuccinate; D016572:Cyclosporine; D003404:Creatinine; D001379:Azathioprine; D016559:Tacrolimus