The IGF system during fetal-placental development of the mouse.
Insulin-like growth factors (IGF-I and -II) promote cellular mitosis and differentiation and have been implicated in fetal and placental growth. Together with the IGF receptors and IGF binding proteins (IGFBPs) they form a complex network, with tissue specific activity. This review will discuss the data generated to elucidate the functions of the IGF system during mouse development.
Department of Pediatrics, Erasmus University Rotterdam, The Netherlands. vankleffens@pa1.fgg.eur.nl
M
M
van Kleffens
C
C
Groffen
D J
DJ
Lindenbergh-Kortleve
J W
JW
van Neck
S
S
González-Parra
N
N
Dits
E C
EC
Zwarthoff
S L
SL
Drop
D000818:Animals; D017209:Apoptosis; D005314:Embryonic and Fetal Development / Q000502:physiology*; D005260:Female; D017353:Gene Deletion; D018969:Insulin-Like Growth Factor Binding Proteins / Q000032:analysis / Q000235:genetics; D051379:Mice; D008822:Mice, Transgenic; D010920:Placenta / Q000502:physiology*; D011247:Pregnancy; D017527:Receptor, IGF Type 2 / Q000235:genetics; D013002:Somatomedins / Q000032:analysis / Q000235:genetics / Q000502:physiology*
D018969:Insulin-Like Growth Factor Binding Proteins; D017527:Receptor, IGF Type 2; D013002:Somatomedins