[The protective action of tocopherol acetate in simultaneous administration with nitrobenzene and its chloro derivatives].
In experiments in albino rats, effects were studied of nitrobenzene and its chloro derivatives in intragastric administration with tocoferolum acetatum. Changes in the process of lipid peroxidation in blood serum, liver, and spleen which were characteristic of xenobiotics themselves have been shown to be less pronounced in this setting. Tocoferolum acetatum being administered at the same time is actively drawn into the metabolism. Normalization of the antioxidant activity of the tissues under investigation was to be observed, with lipid peroxidation and the antioxidant system being in equilibrium. Tocoferolum acetatum administered with xenobiotics has been shown to have a protective action. Tocoferolum acetatum is recommended to be included into diets for workers engaged in chemical industry on a prophylactic basis.
Paranich
A V
AV
Paranich
L I
LI
Bugaĭ
E V
EV
Ortis
L F
LF
D000284:Administration, Oral; D000818:Animals; D000931:Antidotes / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000975:Antioxidants / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004353:Drug Evaluation, Preclinical; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009578:Nitrobenzenes / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000506:poisoning; D011041:Poisoning / Q000378:metabolism / Q000517:prevention & control; D051381:Rats; D014018:Tissue Distribution; D024505:Tocopherols; D014810:Vitamin E / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D000931:Antidotes; D000975:Antioxidants; D009578:Nitrobenzenes; D014810:Vitamin E; C010407:4-chloronitrobenzene; C032785:2-chloronitrobenzene; C036077:nitrobenzene; D024502:alpha-Tocopherol; D024505:Tocopherols