Allylamine type xanthone antimycotics.
A number of xanthone derivatives bearing the basic chain of naftifine and butenafine antimycotics in 1, 2, 3, and 4 nuclear positions are described. The in vitro antifungal activity against representative strains of molds and yeasts is reported. Only butenafine xanthone analogues show significant activity against Cryptococcus neoformans, in particular the regioisomer 4d (1.5 micrograms/ml).
Institute of Pharmaceutical Chemistry, University of Milan, Italy.
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Salmoiraghi
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Rossi
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Valenti
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Da Re
D000499:Allylamine / Q000031:analogs & derivatives / Q000737:chemistry; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001234:Aspergillus niger / Q000187:drug effects / Q000254:growth & development; D001596:Benzylamines / Q000737:chemistry; D002176:Candida albicans / Q000187:drug effects / Q000254:growth & development; D003455:Cryptococcus neoformans / Q000187:drug effects / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000737:chemistry; D010407:Penicillium / Q000187:drug effects / Q000254:growth & development; D013329:Structure-Activity Relationship; D014966:Xanthenes / Q000737:chemistry / Q000494:pharmacology*
D000935:Antifungal Agents; D001596:Benzylamines; D009281:Naphthalenes; D014966:Xanthenes; D000499:Allylamine; C029178:naftifine; C067594:butenafine