Alterations in pulmonary artery flow patterns and shear stress determined with three-dimensional phase-contrast magnetic resonance imaging in Fontan patients.
OBJECTIVE
This study compares in vivo pulmonary blood flow patterns and shear stresses in patients with either the direct atrium-pulmonary artery connection or the bicaval tunnel connection of the Fontan procedure to those in normal volunteers. Comparisons were made with the use of three-dimensional phase contrast magnetic resonance imaging.


METHODS
Three-dimensional velocities, flows, and pulmonary artery cross-sectional areas were measured in both pulmonary arteries of each subject. Axial, circumferential, and radial shear stresses were calculated with the use of velocities and estimates of viscosity.


RESULTS
The axial velocities were not significantly different between subject groups. However, the flows and cross-sectional areas were higher in the normal group than in the two patient groups in both pulmonary arteries. The group with the bicaval connection had circular swirling in the cross section of both pulmonary arteries, causing higher shear stresses than in the controls. The disorder caused by the connection of the atrium to the pulmonary artery caused an increase in some shear stresses over the controls, but not higher than those found in the group having a bicaval tunnel.


CONCLUSIONS
We found that pulmonary flow was equally reduced compared with normal flow in both patient groups. This reduction in flow can be attributed in part to the reduced size of the pulmonary arteries in both patient groups without change in axial velocity. We also found higher shear stress acting on the wall of the vessels in the patients having a bicaval tunnel, which may alter endothelial function and affect the longevity of the repair.
Department of Biomedical Engineering, Vanderbilt University, Nashville, Tenn, USA.
V L
VL
Morgan
T P
TP
Graham
R J
RJ
Roselli
C H
CH
Lorenz
D000293:Adolescent; D000328:Adult; D000714:Anastomosis, Surgical; D001783:Blood Flow Velocity; D002648:Child; D002675:Child, Preschool; D005260:Female; D018729:Fontan Procedure; D006325:Heart Atria / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D011651:Pulmonary Artery / Q000473:pathology / Q000503:physiopathology*; D018633:Pulmonary Atresia / Q000175:diagnosis / Q000601:surgery; D013312:Stress, Physiological / Q000503:physiopathology; D013599:Systole; D014261:Tricuspid Valve / Q000002:abnormalities / Q000601:surgery; D014684:Venae Cavae / Q000601:surgery*