Cytokines in the modulation of eosinophilia.
In this review we discuss our recently results showing interleukin 5 (IL-5) involvement in eosinophil migration and in the maintenance of eosinophilia in blood, bone marrow, lung and peritoneal cavity, in a visceral larva migrans syndrome model using guinea-pigs infected with Toxocara canis. We also describe the sequential release of TNF-alpha and IL-8 during the course of infection. Finally we propose a biological role for IL-5, at least in our model, as a modulator of IL-8 release and secretion.
Departamento de Parasitologia, Microbiologia e Imunologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brasil. faccioli@fmrp.usp.br
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LH
Faccioli
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BB
Vargaftig
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Medeiros
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A
Malheiros
D000818:Animals; D016207:Cytokines / Q000502:physiology*; D004802:Eosinophilia / Q000276:immunology*; D004804:Eosinophils / Q000502:physiology*; D006168:Guinea Pigs; D007816:Larva Migrans, Visceral / Q000276:immunology*; D017166:Toxocara canis / Q000276:immunology*
D016207:Cytokines