The reactions of H-phosphonates with bifunctional reagents. Part V. Functionalization of support-bound oligonucleotides and synthesis of non-radioactive hybridization probes.
Three methods for the functionalization of oligonucleotides with aminoalkyl moieties have been developed and their efficiencies were evaluated in the preparation of non-radioactive hybridization probes.
Sobkowski
M
M
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland.
Kraszewski
A
A
Stawiński
J
J
D015342:DNA Probes / Q000138:chemical synthesis*; D015394:Molecular Structure; D009693:Nucleic Acid Hybridization / Q000379:methods*; D009841:Oligonucleotides / Q000138:chemical synthesis; D063065:Organophosphonates / Q000138:chemical synthesis*
D015342:DNA Probes; D009841:Oligonucleotides; D063065:Organophosphonates