Latex allergy in spina bifida patients--prevention by primary prophylaxis.
BACKGROUND
The effect of latex prophylaxis has not been investigated in spina bifida children, a high-risk group for latex allergy. As repeated operations have been identified as a major cause of latex sensitization, we wanted to find out whether primary latex prophylaxis during surgery could prevent latex allergy in children with spina bifida.


METHODS
In December 1995, we established latex-free surgery and anesthesia for all patients with spina bifida regardless of their sensitization to latex. Twelve children born after that date (mean age 1.2 years, mean number of operations 3.3, range 1-7) were tested for specific IgE against latex until December 1997 (ImmunoCap, Pharmacia, Uppsala, Sweden) and compared with eight children born before December 1995 (mean age 1.3 years, mean number of operations 3.6, range 1-8), in whom a test for latex IgE had been done before the age of 2 years.


RESULTS
Before we established primary prophylaxis, three of seven children with spina bifida (38%) were sensitized to latex until the age of 2 years. After the establishment of a latex-free operating theater for spina bifida patients, none of the 12 patients were sensitized to latex despite up to seven operations in each child.


CONCLUSIONS
Primary latex prophylaxis during surgery can prevent latex sensitization in young spina bifida patients.
Cremer
R
R
Children's Hospital, Paediatric Clinic, Cologne, Germany.
Kleine-Diepenbruck
U
U
Hoppe
A
A
Bläker
F
F
D000485:Allergens / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D006967:Hypersensitivity / Q000517:prevention & control*; D007223:Infant; D007840:Latex / Q000276:immunology*; D008137:Longitudinal Studies; D016135:Spinal Dysraphism / Q000601:surgery*
D000485:Allergens; D007840:Latex