Effect of direct thrombin inhibition with Bivalirudin (Hirulog) on restenosis after coronary angioplasty.
The direct antithrombin, bivalirudin, did not reduce angiographic restenosis measured either as the dichotomous restenosis rate of 62% for bivalirudin and 58% for heparin (p = 0.70), or as the late loss in lumen diameter of 0.44 +/- 0.47 mm for bivalirudin and 0.39 +/- 0.53 mm for heparin (p = 0.62). Direct thrombin inhibition with bivalirudin neither reduces angiographic restenosis nor alters the impact of several established risk factors for restenosis.
Burchenal
J E
JE
Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Marks
D S
DS
Tift Mann
J
J
Schweiger
M J
MJ
Rothman
M T
MT
Ganz
P
P
Adelman
B
B
Bittl
J A
JA
D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D000991:Antithrombins / Q000627:therapeutic use*; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000517:prevention & control* / Q000628:therapy; D005260:Female; D006493:Heparin / Q000627:therapeutic use; D024764:Hirudin Therapy; D006629:Hirudins / Q000031:analogs & derivatives*; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000627:therapeutic use*; D011859:Radiography; D011994:Recombinant Proteins / Q000627:therapeutic use; D012008:Recurrence; D012307:Risk Factors; D016896:Treatment Outcome
D000991:Antithrombins; D006629:Hirudins; D010446:Peptide Fragments; D011994:Recombinant Proteins; D006493:Heparin; C074619:bivalirudin