[Human cervico-facial morphogenesis. Evaluation of acquired data and current outlook. Second part: cervical morphogenesis].
After having recalled the formation of the so-called "branchial" organisation, each component of the segmentary units constituting this organisation is analysed, as well as their particularities. This lead us to recognize the existence of only five branchial arches in the human embryo, without an intermediary arch between the fourth arch and the pulmonary arch. This question is moreover linked to the signification of the so-called "ultimobranchial" body, which must be connected with the fourth pharyngeal pouch. The question of cervical segmentation is inseparable from the question of cephalic metamerisation. Two segments are individualised in front of the mandibular process: the fronto-nasal process and the maxillary process, corresponding to premandibular arches, which existence is well established in paleontology. In addition to the peripheral expression of this cervico-cephalic segmentation marqued by primitive characters. We observe the paraxial expression of segmentation by the somitomeres and the somites. Recent data provided by the developmental genes confirm that only one process is at the origin of these two expressions which appear distinct, but lead to a unitary organisation. The mutation of the gene Pax 6 affecting in the same time the nasal placode and the optic vesicle confirms the unity of the fronto-nasal process. The pre-eminence of genetic expression on skeletal, muscular and nervous tissues with respect to the vascular system confirms the inadequacy of the criterion given by the aortic arches for the analysis of the cervico-cephalic development, although it is classically linked to the concept of an embryonic "branchial apparatus".
Laboratoire d'Histologie Embryologie Cytogénétique, Faculté de Médicine Lariboisière Saint-Louis, Paris.
J P
JP
Onolfo
F
F
Leperchey
J P
JP
Barbet
D005075:Biological Evolution; D001934:Branchial Region / Q000196:embryology; D003627:Data Interpretation, Statistical; D005145:Face / Q000196:embryology*; D006801:Humans; D009024:Morphogenesis; D009333:Neck / Q000196:embryology*; D013961:Thyroid Gland / Q000196:embryology; D014059:Tongue / Q000196:embryology