Lymphomatoid granulomatosis--a report on four cases: evidence for B phenotype of the tumoral cells.
Four cases of lymphomatoid granulomatosis are reported, three of them involving the lung. Histological features included a true angiocentric and angiodestructive polymorphic cellular proliferation. This included histiocytes, plasma cells, many reactive T-cells and rare large, atypical cells which were of the B phenotype. Epstein-Barr virus was detected in the atypical cells by in situ hybridization in three cases, with expression of both latent membrane proteins (LMP)-1 and Epstein-Barr nuclear antigen-2 in two cases and expression of only LMP-1 in the third case. Expression of both of these proteins suggests a defect in the T-cell-mediated immunity and that Epstein-Barr virus is not only a silent passenger but may also be involved in the pathogenesis of the disease. This could have implications for therapy.
Laboratoire d'Anatomie Pathologique de l'Hôpital E. Herriot, Lyon, France.
P
P
Tanière
F
F
Thivolet-Béjui
D
D
Vitrey
S
S
Isaac
R
R
Loire
J F
JF
Cordier
F
F
Berger
D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D001402:B-Lymphocytes / Q000473:pathology*; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D019309:Epstein-Barr Virus Nuclear Antigens / Q000032:analysis; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D017403:In Situ Hybridization; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D008230:Lymphomatoid Granulomatosis / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D051907:Lysosomal Membrane Proteins; D008297:Male; D008562:Membrane Glycoproteins / Q000032:analysis; D008875:Middle Aged
D015703:Antigens, CD; D019309:Epstein-Barr Virus Nuclear Antigens; D051907:Lysosomal Membrane Proteins; D008562:Membrane Glycoproteins