Mechanisms of protein sorting and coat assembly: insights from the clathrin-coated vesicle pathway.
Clathrin-coated vesicles have provided the best example illustrating how both soluble and membrane proteins are selectively clustered into a transport intermediate for subsequent delivery to another intracellular compartment. Like cytosolic clathrin adaptors, the adaptor-like complex AP-3 binds to specific membranes and selects membrane proteins by interacting with their sorting signals.
Le Borgne
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R
Institut de Biologie de Lille, CNRS EP 525, France.
Hoflack
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B
D033965:Adaptor Protein Complex alpha Subunits; D033942:Adaptor Proteins, Vesicular Transport; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D002966:Clathrin / Q000378:metabolism*; D018699:Coated Vesicles / Q000378:metabolism*; D007930:Leucine / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D034041:Monomeric Clathrin Assembly Proteins; D011506:Proteins / Q000378:metabolism*; D014443:Tyrosine / Q000378:metabolism
D033965:Adaptor Protein Complex alpha Subunits; D033942:Adaptor Proteins, Vesicular Transport; D002966:Clathrin; D008565:Membrane Proteins; D034041:Monomeric Clathrin Assembly Proteins; D011506:Proteins; C439023:clathrin assembly protein AP180; D014443:Tyrosine; D007930:Leucine