Burst firing and modulation of functional connectivity in cat striate cortex.
We studied the influences of the temporal firing patterns of presynaptic cat visual cortical cells on spike generation by postsynaptic cells. Multiunit recordings were dissected into the activity of individual neurons within the recorded group. Cross-correlation analysis was then used to identify directly coupled neuron pairs. The 22 multiunit groups recorded typically showed activity from two to six neurons, each containing between 1 and 15 neuron pairs. From a total of 241 neuron pairs, 91 (38%) had a shifted cross-correlation peak, which indicated a possible direct connection. Only two multiunit groups contained no shifted peaks. Burst activity, defined by groups of two or more spikes with intervals of </=8 ms from any single neuron, was analyzed in terms of its effectiveness in eliciting a spike from a second, driven neuron. We defined effectiveness as the percentage of spikes from the driving neuron that are time related to spikes of the driven neuron. The effectiveness of bursts (of any length) in eliciting a time-related response spike averaged 18.53% across all measurements as compared with the effectiveness of single spikes, which averaged 9.53%. Longer bursts were more effective than shorter ones. Effectiveness was reduced with spatially nonoptimal, as opposed to optimal, stimuli. The effectiveness of both bursts and single spikes decreased by the same amount across measurements with nonoptimal orientations, spatial frequencies and contrasts. At similar firing rates and burst lengths, the decrease was more pronounced for nonoptimal orientations than for lower contrasts, suggesting the existence of a mechanism that reduces effectiveness at nonoptimal orientations. These results support the hypothesis that neural information can be emphasized via instantaneous rate coding that is not preserved over long intervals or over trials. This is consistent with the integrate and fire model, where bursts participate in temporal integration.
Department of Electrical and Computer Engineering, Vanderbilt University, Nashville Tennessee 37235, USA.
R K
RK
Snider
J F
JF
Kabara
B R
BR
Roig
A B
AB
Bonds
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D002415:Cats; D015350:Contrast Sensitivity / Q000502:physiology; D005074:Evoked Potentials, Visual / Q000502:physiology; D009434:Neural Pathways; D009475:Neurons, Afferent / Q000502:physiology; D010507:Periodicity; D010775:Photic Stimulation; D009435:Synaptic Transmission / Q000502:physiology; D013997:Time Factors; D014793:Visual Cortex / Q000166:cytology* / Q000502:physiology*