Tramadol hydrochloride: an overview of current use.
Tramadol's two enantiomers produce analgesia, in acute and chronic pain states, by combining synergistically, weak opioid and monoaminergically-mediated mechanisms. Tramadol is interesting, being free of some of the clinically significant side-effects seen with other opioids of comparable efficacy.
Bamigbade
T A
TA
St. Bartholomew's, London.
Langford
R M
RM
D000208:Acute Disease; D000701:Analgesics, Opioid / Q000378:metabolism / Q000494:pharmacology; D002908:Chronic Disease; D004357:Drug Synergism; D006801:Humans; D007536:Isomerism; D008099:Liver / Q000378:metabolism; D010146:Pain / Q000188:drug therapy; D014147:Tramadol / Q000378:metabolism / Q000494:pharmacology
D000701:Analgesics, Opioid; D014147:Tramadol