Improved quantification of myocardial mass by three-dimensional echocardiography using a deposit contrast agent.
The aim of the study was to assess the usefulness of a novel contrast agent in combination with three-dimensional echocardiography for improved mass quantification. Three-dimensional reconstruction of left ventricular myocardium was performed from images obtained with rotational epicardial acquisition in eight open-chested pigs, before and after injection of a deposit contrast agent, Quantison Depot. Three-dimensional echocardiographic myocardial mass values were in excellent agreement with weighted mass (differences -1.6 +/- 5.0 g for end-diastolic frame, -2.8 +/- 4.5 g for end-systolic, 1.0 +/- 1.0 g for end-diastolic with contrast and 0.6 +/- 2.0 g for end-systolic with contrast, p = NS). Left ventricular mass measurements after contrast injection were more accurate and had less measurement variability. In conclusion, myocardial contrast enhancement improves left ventricular mass calculation with three-dimensional echocardiography.
Thoraxcentre, University Hospital Rotterdam-Dijkzigt, The Netherlands. jdkasprzak@hotmail.com
J D
JD
Kasprzak
W B
WB
Vletter
J R
JR
van Meegen
Y F
YF
Nosir
R
R
Johnson
F J
FJ
Ten Cate
J R
JR
Roelandt
D000704:Analysis of Variance; D000818:Animals; D002214:Capsules; D003287:Contrast Media / Q000494:pharmacology; D003692:Delayed-Action Preparations; D019560:Echocardiography, Three-Dimensional / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D005069:Evaluation Studies as Topic; D006321:Heart / Q000033:anatomy & histology; D006439:Hemodynamics / Q000187:drug effects; D009929:Organ Size; D015203:Reproducibility of Results; D012709:Serum Albumin / Q000494:pharmacology; D000075462:Serum Albumin, Human; D013552:Swine
D002214:Capsules; D003287:Contrast Media; D003692:Delayed-Action Preparations; C114780:Quantison Depot; D012709:Serum Albumin; D000075462:Serum Albumin, Human