Synthesis and antiviral evaluation of pyrazinones substituted with acyclic chains.
The synthesis of a series of pyrazine analogues of the anti-herpes compound, acyclovir is described. These syntheses were accomplished by various methods: in the presence of a Lewis acid or NaH for hydroxyethoxymethyl and hydroxybutyl groups or by sequential oxidation/reduction of 1-(beta-D-ribofuranosyl)-2-pyrazinones for 2',3'-acyclonucleosides. Antiviral (HSV-1, CMV, Cox B4, HIV-1) properties of these compounds were determined.
Davis
J
J
Laboratoire de Chimie des Substances Naturelles, Université de Limoges, France.
Benhaddou
R
R
Granet
R
R
Krausz
P
P
Demonte
M
M
Aubertin
A M
AM
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002460:Cell Line; D003587:Cytomegalovirus / Q000187:drug effects; D015195:Drug Design; D029822:Enterovirus B, Human / Q000187:drug effects; D018259:Herpesvirus 1, Human / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D011719:Pyrazines / Q000138:chemical synthesis* / Q000494:pharmacology; D014616:Vaccinia virus / Q000187:drug effects
D000998:Antiviral Agents; D011719:Pyrazines