Myolipoma of the eyelid.
BACKGROUND
This report describes the pathology of a myolipoma which occurred in the eyelid. Myolipoma is a benign hamartomatous tumour in which smooth muscle cells are interspersed with adipocytes. PATIENT DETAILS: An irregular yellowish tumour (30 x 25 mm) with illdefined borders had been present for 50 years in the medial part of the left lower eyelid of a 67-year-old woman. The tumour was excised and studied by conventional histology, immunohistochemistry and transmission electron microscopy.


RESULTS
The tumour was formed by bundles of spindle-shaped cells with cigarshaped nuclei intermingled with multiloculated clear cells containing small eccentric nuclei. By immunohistochemistry, positive staining of the spindle cells was restricted to smooth muscle actin and desmin; the clear cells were non-reactive with the immunohistochemical panel, but fat was identified within the cytoplasm. The ultrastructural features of the spindle cells were those of a leiomyoma, while the clear cells were classified as adipocytes.


CONCLUSIONS
This tumour was considered to originate from the media of blood vessels within the tumour.
Department of Pathology, University of Glasgow, UK.
N
N
Sharara
W R
WR
Lee
C
C
Weir
D000199:Actins / Q000378:metabolism; D017667:Adipocytes / Q000378:metabolism / Q000648:ultrastructure; D000368:Aged; D005142:Eyelid Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007381:Intermediate Filament Proteins / Q000378:metabolism; D008067:Lipoma / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D018396:Mucin-1 / Q000378:metabolism; D009130:Muscle, Smooth / Q000378:metabolism / Q000648:ultrastructure; D008941:Spindle Apparatus / Q000378:metabolism / Q000648:ultrastructure
D000199:Actins; D007381:Intermediate Filament Proteins; D018396:Mucin-1