[Effect of prenatal treatment with diethylstilbestrol on 1,2-dimethylhydrazine-induced carcinogenesis in male CBA mice].
Female CBA mice were injected 1 mg/kg diethylstilbestrol (DES) on day 17 of gestation. Their male progeny received 15 weekly injections of 1,2-dimethylhydrazine (DMH) starting from the age of 2 months. Prenatal treatment with DES was followed by a significant acceleration and higher frequency of DMH-induced renal adenomas and renal capsule sarcomas in males. Tumor-induction was significantly enhanced by androgen effect. This was matched by a higher frequency of induced tumors of the large bowel. The increased frequency of androgen-dependent renal malignancies, served as indirect evidence of hyperandrogenization being stimulated in CBA male mice by prenatal treatment with DES.
Research Institute of Carcinogenesis, Moscow.
L S
LS
Trukhanova
D V
DV
Samoĭlov
V S
VS
Turusov
D019813:1,2-Dimethylhydrazine; D000236:Adenoma / Q000139:chemically induced*; D000818:Animals; D002273:Carcinogens / Q000008:administration & dosage / Q000009:adverse effects*; D003110:Colonic Neoplasms / Q000139:chemically induced*; D004054:Diethylstilbestrol / Q000008:administration & dosage / Q000009:adverse effects*; D007680:Kidney Neoplasms / Q000139:chemically induced*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D012513:Sarcoma, Experimental / Q000139:chemically induced*
D002273:Carcinogens; D004054:Diethylstilbestrol; D019813:1,2-Dimethylhydrazine