Glomerular filtration rate, effective renal plasma flow, blood pressure and pulse rate in the equine neonate during the first 10 days post partum.
The aim of this study was to determine glomerular filtration rate (GFR), effective renal plasma flow (RPF) and filtration fraction (FF) values in Pony foals during the first 10 days post partum in order to assess any age-related changes and the reliability of the single injection inulin/p-aminohippurate (PAH) method. Arterial blood pressure and pulse rate were determined in Pony and Thoroughbred (TB) foals during the first 10 days post partum to establish age-related changes, differences between breeds and possible interrelationships with GFR and RPF. Inulin and PAH were injected intravenously (i.v.) in healthy Pony foals (n = 6) on Days 1, 2, 4, 7 and 10 post partum. Blood samples were collected via the contralateral jugular catheter over a 4 h period. Plasma clearances of inulin and PAH showed that GFR and RPF, respectively, remained relatively constant throughout the post natal period, and were similar to values reported for mature horses. The GFR measurements obtained using the inulin method gave clearance values that were significantly higher (P < 0.01) than those of creatinine clearance performed in a separate group of Pony foals (n = 7). Blood pressure and pulse rates were measured using an electronic sphygmomanometer in TB (n = 6) and Pony foals (n = 7) on Days 1, 2, 3, 4, 7 and 10 postpartum. There were no significant differences in these measurements between the breeds, and both cardiovascular parameters increased during the first 3 days post partum. Values remained unchanged for the rest of the study period. Although measurements of GFR, RPF, blood pressure and pulse rates were not determined in the same animals, blood pressure and pulse rates did not appear to correlate with either GFR or RPF in the Pony foals during the post natal period.
Beaufort Cottage Stables, Newmarket, Suffolk, UK.
N B
NB
Holdstock
J C
JC
Ousey
P D
PD
Rossdale
D000375:Aging / Q000502:physiology; D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001794:Blood Pressure; D001947:Breeding; D005260:Female; D005919:Glomerular Filtration Rate / Q000662:veterinary*; D006736:Horses / Q000502:physiology*; D007444:Inulin / Q000493:pharmacokinetics; D008297:Male; D011674:Pulse; D017595:Renal Plasma Flow; D010130:p-Aminohippuric Acid / Q000493:pharmacokinetics
D007444:Inulin; D010130:p-Aminohippuric Acid