Molecular cloning and expression of human chondroitin 6-sulfotransferase.
Using cDNA of chick chondroitin 6-sulfotransferase (C6ST), human C6ST cDNA has been isolated. The amino acid sequence of human C6ST displayed 74% identity to chick C6ST. The major difference in amino acid sequence between chick C6ST and human C6ST was the presence of a unique hydrophilic domain in human C6ST. A 7.8-kb message of C6ST was expressed ubiquitously in various human adult tissues, indicating a rather diverse function of C6ST.
Department of Life Science, Aichi University of Education, Japan.
M
M
Fukuta
Y
Y
Kobayashi
K
K
Uchimura
K
K
Kimata
O
O
Habuchi
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000378:metabolism; D019556:COS Cells; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000737:chemistry / Q000302:isolation & purification; D015870:Gene Expression; D006801:Humans; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D015238:Sulfotransferases / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics*; D014162:Transfection; D000097811:Carbohydrate Sulfotransferases
D018076:DNA, Complementary; D015238:Sulfotransferases; D000097811:Carbohydrate Sulfotransferases