Epstein-Barr virus DNA in cerebrospinal fluid from an immunocompetent man with herpes simplex virus encephalitis.
Herpes simplex virus 1 meningo-encephalitis was ascertained in a 63-year-old immunocompetent man. To determine the duration of the persistence of herpesvirus DNA in the central nervous system, the cerebrospinal fluid was periodically monitored by polymerase chain reaction for 53 days. In addition to HSV-1, Epstein-Barr virus DNA was detected in the cerebrospinal fluid 9 days after disease onset. The possible meaning of the Epstein-Barr virus DNA finding is discussed.
Centre for Diagnosis of Viral Diseases, University Hospital of Modena, Italy.
M
M
Portolani
A M
AM
Sabbatini
M
M
Meacci
P
P
Pietrosemoli
C
C
Cermelli
P
P
Lunghi
F
F
Golinelli
R
R
Stacca
D004279:DNA, Viral / Q000032:analysis / Q000134:cerebrospinal fluid; D018792:Encephalitis, Viral / Q000134:cerebrospinal fluid* / Q000276:immunology; D020031:Epstein-Barr Virus Infections / Q000134:cerebrospinal fluid* / Q000276:immunology; D006561:Herpes Simplex / Q000134:cerebrospinal fluid* / Q000276:immunology; D018259:Herpesvirus 1, Human; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D007121:Immunocompetence; D008297:Male; D008875:Middle Aged
D004279:DNA, Viral