Photoaffinity labeling of human P-glycoprotein: effect of modulator interaction and ATP hydrolysis on substrate binding.
Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
S
S
Dey
M
M
Ramachandra
I
I
Pastan
M M
MM
Gottesman
S V
SV
Ambudkar
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000378:metabolism*; D000345:Affinity Labels / Q000493:pharmacokinetics; D000818:Animals; D001386:Azides / Q000493:pharmacokinetics; D016367:Baculoviridae; D018929:Cell Culture Techniques / Q000379:methods; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D002846:Chromatography, Affinity / Q000379:methods; D018432:Drug Resistance, Multiple; D004591:Electrophoresis, Polyacrylamide Gel / Q000379:methods; D006801:Humans; D007202:Indicators and Reagents; D007457:Iodine Radioisotopes; D007700:Kinetics; D011224:Prazosin / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D011994:Recombinant Proteins / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D018411:Spodoptera; D014162:Transfection / Q000379:methods; D014638:Vanadates / Q000493:pharmacokinetics / Q000494:pharmacology
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000345:Affinity Labels; D001386:Azides; D007202:Indicators and Reagents; D007457:Iodine Radioisotopes; D011994:Recombinant Proteins; D014638:Vanadates; D000255:Adenosine Triphosphate; C041552:azidoprazosin; D011224:Prazosin