A gene network approach to modeling early neurogenesis in Drosophila.
We have produced a model of genetic regulation to simulate how neuroblasts and sensory organ precursor (SOP) cells differentiate from proneural clusters of equivalent cells. Parameters of the model (mainly gene interaction strengths) are optimized in order to fit schematic patterns of expression, drawn from the literature, of genes that are involved in this process of cell fate specification. The model provides suggestions about the role of lateral signalling in neurogenesis and yields specific and testable predictions about the timing and position of appearance of neuroblasts and SOPs within proneural clusters, and about the dynamics of gene expression in individual cells. Experimental testing of these predictions and fits to more accurate quantitative data will help determine which set of model parameters can best describe early neurogenesis.
Marnellos
G
G
Sloan Center for Theoretical Neurobiology, Salk Institute, San Diego, CA 92186, USA.
Mjolsness
E
E
D000818:Animals; D003198:Computer Simulation; D004330:Drosophila / Q000196:embryology* / Q000235:genetics; D004848:Epithelium / Q000196:embryology; D005786:Gene Expression Regulation; D018507:Gene Expression Regulation, Developmental; D019476:Insect Proteins / Q000235:genetics; D008957:Models, Genetic; D009420:Nervous System / Q000196:embryology*; D015398:Signal Transduction
D019476:Insect Proteins