"Subclinical" dosages of lithium and pilocarpine that do not evoke overt seizures affect long-term spatial memory but not learning in rats.
After training is an automated radial maze, 11 male rats were injected with either "subclinical" dosages of lithium and pilocarpine or saline and then tested 5 days or 4 months later. When employed as their own controls or when compared with a saline-injected reference group, the rats that had received the lithium and pilocarpine displayed memory deficits but not learning learning deficits after the longest of the two delays (effect size was 41%). These results suggest that subtle disruption in memory but not learning to criterion could be associated with "subclinical electrical seizures" or the micromorphological changes associated with this activity.
Neuroscience Laboratory, Laurentian University, Sudbury, Ontario, Canada.
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Cook
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Persinger
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007279:Injections, Subcutaneous; D008094:Lithium / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D008568:Memory / Q000187:drug effects*; D010862:Pilocarpine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced*; D012965:Sodium Chloride / Q000008:administration & dosage / Q000494:pharmacology
D010862:Pilocarpine; D012965:Sodium Chloride; D008094:Lithium