Thiopentone and propofol: a compatible mixture?
The physical compatibility of thiopentone and propofol mixtures was investigated. The investigations used were macroscopic and microscopic observations, zeta potential and oil droplet size measurements. There was no evidence of instability in the mixtures. The thiopentone-propofol mixture has the potential advantage of reducing the pain on injection, provides synergistic interaction, does not prolong recovery when used for induction of anaesthesia, may reduce the incidence of convulsions and is cost-effective.
Department of Anaesthesia, James Paget Hospital, Gorleston, Great Yarmouth, UK.
H G
HG
Paw
M
M
Garrood
A J
AJ
Fillery-Travis
G T
GT
Rich
D000762:Anesthesia Recovery Period; D018686:Anesthetics, Intravenous / Q000737:chemistry* / Q000191:economics; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003362:Cost-Benefit Analysis; D004355:Drug Stability; D004357:Drug Synergism; D004553:Electric Conductivity; D004563:Electrochemistry; D004655:Emulsions / Q000737:chemistry; D006801:Humans; D015994:Incidence; D007275:Injections, Intravenous / Q000009:adverse effects; D010146:Pain / Q000517:prevention & control; D015742:Propofol / Q000737:chemistry* / Q000191:economics; D012640:Seizures / Q000517:prevention & control; D013874:Thiopental / Q000737:chemistry* / Q000191:economics
D018686:Anesthetics, Intravenous; D004655:Emulsions; D013874:Thiopental; D015742:Propofol