In vivo cardiotonic activity of pyridylmethylene-2-indolinones.
The synthesis of 5-chloro-3-pyridylmethylene-2-indolinone is reported. This compound was subjected to an in vivo cardiotonic assay with 10 analogs whose synthesis and in vitro cardiotonic activity were previously reported. All the compounds tested (except the 5-hydroxyindole derivative) showed significant positive inotropic activity. The 3-pyridyl derivative without substituents at the indole system was the most active of the whole series.
Dipartimento di Scienze Farmaceutiche, Università di Bologna, Italy.
A
A
Andreani
A
A
Locatelli
R
R
Morigi
A
A
Leoni
R
R
Bossa
M
M
Chiericozzi
I
I
Galatulas
D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology*; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D007211:Indoles / Q000138:chemical synthesis / Q000494:pharmacology*; D008297:Male; D020105:Milrinone; D009200:Myocardial Contraction / Q000187:drug effects; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology*; D011728:Pyridones / Q000494:pharmacology; D013329:Structure-Activity Relationship; D016277:Ventricular Function, Left / Q000187:drug effects
C114210:5-chloro-3-pyridylmethylene-2-indolinone; D002316:Cardiotonic Agents; D007211:Indoles; D011725:Pyridines; D011728:Pyridones; D020105:Milrinone