[Autoimmune hepatitis with antibodies against liver cytosol (anti-LC1)].
Antibody against liver cytosol (anti-LC1) was proposed in 1988 as a new and very specific immunoserologic marker of autoimmune hepatitis of childhood and young age. In adults, anti-LC1 might be masked by the presence in serum of anti-LKM1, usually associated with antibodies to hepatitis-C virus. We report the case of a 60-year-old woman who had active chronic hepatitis not related to infection by hepatitis C virus, with autoantibody reacting against liver cytosol as the unique marker of autoimmune hepatitis. Treated with corticosteroids (prednisone, 1 mg/kg per day), coagulation disorder, bilirubin, transaminase activity and immunoglobulins normalized in the following months. A year and a half later, autoantibodies anti-LC1 and p-ANCAs were no longer detected. We have only found one report of a young patient with anti-LC1 autoimmune hepatitis who had cirrhosis and portal hypertension, in national publications.
Cosme
A
A
Servicio de Digestivo, Hospital de Arantzazu, San Sebastián.
Gil
I
I
Alvarez
R
R
Ruiz
I
I
de Juan
M D
MD
Ojeda
E
E
Barrio
J
J
D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D001706:Biopsy; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D019693:Hepatitis, Autoimmune / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D006801:Humans; D015151:Immunoblotting; D008099:Liver / Q000473:pathology; D008875:Middle Aged; D013997:Time Factors
D001323:Autoantibodies; C094307:anti-liver cytosolic protein 1