Advanced pancreatic cancer successfully treated with continuous infusion of 5-fluorouracil and low-dose cisplatin.
Due to pyloric stenosis in a 59-year-old male with the diagnosis of unresectable pancreatic head cancer, gastro-jejunostomy and cholecysto-jejunostomy were performed. Following the operation, the patient underwent a combination chemotherapy with cisplatin 10 mg/day x 5/week and continuous infusion of 5-fluorouracil 500 mg/day for 4 weeks. After three courses, the tumor size decreased and the serum carcinoembryonic antigen (CEA) level decreased from 89.6 to 4.2 ng/ml without significant adverse effects. During the follow-up, the CEA increased and the patient is now receiving the same treatment, surviving for more than one year.
Division of Pharmacotherapy, the Research Institute, Miyagi Cancer Center, Natori.
H
H
Kikuchi
S
S
Ujiie
R
R
Kanamaru
D000230:Adenocarcinoma / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D002272:Carcinoembryonic Antigen / Q000097:blood; D002945:Cisplatin / Q000008:administration & dosage; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007262:Infusions, Intravenous; D007582:Jejunostomy; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed
D002272:Carcinoembryonic Antigen; D002945:Cisplatin; D005472:Fluorouracil