Hyperprolactinemic recurrent miscarriage and results of randomized bromocriptine treatment trials.
OBJECTIVE
To evaluate hyperprolactinemia in the pathogenesis of recurrent spontaneous abortion.


METHODS
Randomized trial.


METHODS
Miscarriage clinic, Yokohama City University Hospital, Yokohama, Japan.


METHODS
From a group of 352 women with recurrent spontaneous abortion, we identified 64 patients with a prolactin disorder that was not associated with any other etiologic abnormalities, including ovarian or endocrinologic disturbances such as luteal phase dysfunction, polycystic ovaries, hypersecretion of LH, galactorrhea, or thyroid hormone disorders.


METHODS
Restoration of prolactin levels with bromocriptine.


METHODS
Successful pregnancy (live birth).


RESULTS
The percentage of successful pregnancies was higher in the bromocriptine-treated group than in the group that was not treated with bromocriptine (85.7% versus 52.4%, P < .05). Serum prolactin levels during early pregnancy (5-10 weeks of gestation) were significantly higher in patients who miscarried (31.8-55.3 ng/mL) than in patients whose pregnancies were successful (4.6-15.5 ng/mL, P < .01 or P < .05).


CONCLUSIONS
Appropriate circulating levels of prolactin may play an important role in maintaining early pregnancy, especially in cases of hyperprolactinemic recurrent miscarriage.
Hirahara
F
F
Department of Obstetrics and Gynecology, Yokohama City University School of Medicine, Yokohama, Japan.
Andoh
N
N
Sawai
K
K
Hirabuki
T
T
Uemura
T
T
Minaguchi
H
H
D000026:Abortion, Habitual / Q000209:etiology / Q000517:prevention & control*; D000328:Adult; D001971:Bromocriptine / Q000627:therapeutic use*; D005260:Female; D006727:Hormone Antagonists / Q000627:therapeutic use*; D006801:Humans; D006966:Hyperprolactinemia / Q000150:complications*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012008:Recurrence
D006727:Hormone Antagonists; D001971:Bromocriptine