Escherichia coli O157:H7 requires intimin for enteropathogenicity in calves.
Enterohemorrhagic Escherichia coli (EHEC) strains require intimin to induce attaching and effacing (A/E) lesions in newborn piglets. Infection of newborn calves with intimin-positive or intimin-negative EHEC O157:H7 demonstrated that intimin is needed for colonization, A/E lesions, and disease in cattle. These results suggest that experiments to determine if intimin-based vaccines reduce O157:H7 levels in cattle are warranted.
Enteric Diseases and Food Safety Research Unit, National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, Iowa 50010, USA. enystrom@nadc.ars.usda.gov
E A
EA
Dean-Nystrom
B T
BT
Bosworth
H W
HW
Moon
A D
AD
O'Brien
D018829:Adhesins, Bacterial; D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000502:physiology*; D002352:Carrier Proteins; D002417:Cattle; D003967:Diarrhea / Q000382:microbiology / Q000473:pathology; D004927:Escherichia coli Infections / Q000382:microbiology* / Q000473:pathology; D019453:Escherichia coli O157 / Q000378:metabolism / Q000472:pathogenicity*; D029968:Escherichia coli Proteins; D013552:Swine
D018829:Adhesins, Bacterial; D001425:Bacterial Outer Membrane Proteins; D002352:Carrier Proteins; D029968:Escherichia coli Proteins; C073819:eaeA protein, E coli