Circulatory effects of whole blood, packed red cells, albumin, starch, and crystalloids in resuscitation of shock and acute critical illness.
Circulatory deficiencies and the effectiveness of transfusion and fluid therapy may be evaluated by invasive and noninvasive monitoring after high risk surgery, hemorrhage, trauma, and sepsis in the ED, OR, and ICU. Earlier recognition and therapy of circulatory problems in emergency and critically ill patients to achieve optimal goals empirically defined by the survivors' patterns is recommended to improve outcome. WB, Prbc, and colloids markedly and statistically significantly improved pressure, flow, and tissue perfusion and best achieved these goals. Noninvasive monitoring may be used in the ED and OR shortly after admission to identify circulatory deficiencies and to titrate therapy, or they may be used initially as the front-end of subsequent invasive monitoring.
Los Angeles County, University of Southern California Medical Center 90033, USA.
W C
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Shoemaker
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Wo
D001803:Blood Transfusion; D003102:Colloids / Q000627:therapeutic use*; D003422:Critical Care; D000077324:Crystalloid Solutions; D003911:Dextrans / Q000627:therapeutic use*; D017707:Erythrocyte Transfusion; D005440:Fluid Therapy; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007552:Isotonic Solutions; D008991:Monitoring, Physiologic; D009102:Multiple Organ Failure / Q000628:therapy; D010952:Plasma Substitutes / Q000627:therapeutic use*; D015532:Rehydration Solutions / Q000627:therapeutic use; D012769:Shock / Q000628:therapy*
D003102:Colloids; D000077324:Crystalloid Solutions; D003911:Dextrans; D007552:Isotonic Solutions; D010952:Plasma Substitutes; D015532:Rehydration Solutions