Implications of oral infections on systemic diseases in the institutionalized elderly with a special focus on pneumonia.
Systemic infection in the elderly patient living in a chronic care setting presents a significant burden to the health care system. The extent to which oral organisms cause systemic infections through hematogenous dissemination in the institutionalized elderly is still unknown. A more likely and common route of systemic infection by oral microorganisms is through aspiration of oropharyngeal fluids containing oral pathogenic microorganisms, which colonize the lower respiratory tract and cause pneumonia. Respiratory pathogens emerge in the dental plaque of elderly patients with very poor oral hygiene and severe periodontal disease. In the chronic care setting, aspiration of oropharyngeal fluids contaminated with these bacteria occurs in patients with diminished host defenses, resulting in bacterial pneumonia. This is also a problem in intensive care units in the hospital setting. In one study, pre-rinsing with a 0.12% chlorhexidine gluconate mouthwash significantly lowered the mortality rate from postsurgical pneumonia in patients undergoing open heart surgery. Selective digestive decontamination, a technique involving the topical application of antimicrobials to reduce the risk of colonization of the respiratory tract, has been used to reduce the incidence of nosocomial pneumonia in the acute care setting of hospitals. This technique has not been employed in the nursing home setting. Whether improving oral hygiene would also lower the risk in either of these settings has not been studied. A number of obstacles must be overcome in designing studies to investigate the relationship between oral infections and lung infections in the institutionalized elderly. Ethical issues must be addressed, and full collaboration of the medical team is required. Future studies should establish whether reducing the risk for pneumonia in the institutionalized elderly is possible through improved oral health.
Faculty of Dentistry, University of Toronto, Canada. hlimeback@dental.utoronto.ca
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D000368:Aged; D002986:Clinical Trials as Topic / Q000379:methods; D003428:Cross Infection; D016321:Dental Care for Aged; D006801:Humans; D007326:Institutionalization; D009735:Nursing Homes; D017063:Outcome Assessment, Health Care; D010510:Periodontal Diseases / Q000150:complications* / Q000382:microbiology / Q000628:therapy; D018410:Pneumonia, Bacterial / Q000209:etiology* / Q000382:microbiology / Q000517:prevention & control; D012107:Research Design; D012307:Risk Factors; D013048:Specimen Handling; D012122:Ventilators, Mechanical / Q000009:adverse effects