Hepatoprotective activity of Trichopus zeylanicus extract against paracetamol-induced hepatic damage in rats.
Trichopus zeylanicus extract has been evaluated for its antihepatotoxic and choleretic activities in rats. The plant leaf suspension (1000 mg/kg; wet weight) as well as its methanol extract (100 mg/kg) showed a remarkable hepatoprotective activity against paracetamol-induced hepatotoxicity as judged from the serum marker enzymes, liver histology and levels of lipid peroxides in liver. The effect of the methanol extract was found to be concentration dependent. The water and hexane extracts were almost inactive. The methanol extract (100 mg/kg) also exhibited choleretic activity in anesthetized normal rats. In short, we report here for the first time the antihepatotoxic as well as choleretic properties of T. zeylanicus.
Ethnopharmacology and Ethnomedicine Divisions, Tropical Botanic Garden and Research Institute, Thiruvananthapuram, India.
A
A
Subramoniam
D A
DA
Evans
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S
Rajasekharan
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P
Pushpangadan
D000082:Acetaminophen / Q000506:poisoning*; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D010936:Plant Extracts; D000082:Acetaminophen