The chemical synthesis of E. coli tRNA(Lys) anticodon loop fragment and its analogues.
E. coli tRNA(Lys) anticodon loop fragment (Umnm5s2UUUt6A) 1 and its analogues 2-6 were synthesized by the classical phosphotriester approach in solution. The preparation of suitably protected derivatives of N6-threonylcarbamoyladenosine 18 is also described.
Institute of Organic Chemistry, Technical University of Lódź, Poland. ejsochac@ck-sg.p.lodz.pl
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D000926:Anticodon / Q000235:genetics*; D004926:Escherichia coli / Q000737:chemistry*; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D009705:Nucleosides / Q000032:analysis; D009843:Oligoribonucleotides / Q000138:chemical synthesis*; D010766:Phosphorylation; D012357:RNA, Transfer, Lys / Q000737:chemistry*
D000926:Anticodon; D009705:Nucleosides; D009843:Oligoribonucleotides; D012357:RNA, Transfer, Lys