Free laminin in the extracellular matrix of B-cell non Hodgkin's lymphomas.
The authors show that in the perivascular stroma of B-cell non-Hodgkin's lymphomas (B-NHL) is present a granular, speckled pattern of expression of laminin, similar to the 'free-laminin' firstly described by Lugassy et al. (1997) in human melanoma. The role of this form of laminin may be to promote the migration of tumor cells, which express a variety of binding-laminin surface proteins, whose expression is significantly increased in several human cancer models.
D
D
Ribatti
A
A
Vacca
B
B
Nico
F
F
Quondamatteo
R
R
Herken
L
L
Roncali
D005109:Extracellular Matrix / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007797:Laminin / Q000032:analysis*; D008198:Lymph Nodes / Q000473:pathology / Q000648:ultrastructure; D016393:Lymphoma, B-Cell / Q000473:pathology / Q000648:ultrastructure*; D016253:Microscopy, Immunoelectron; D017154:Stromal Cells / Q000473:pathology / Q000648:ultrastructure
D007797:Laminin