Goodpasture's syndrome associated with multiple sclerosis.
Multiple sclerosis (MS) has been reported to occur in association with other autoimmune diseases. Here we report the case of a woman with primary progressive MS who developed and died of Goodpasture's syndrome associated with anti-glomerular basement membrane antibodies. Of interest she had the human leukocyte antigen haplotype (DRB1*1501-DQA1*0102-DQB1*0602) most frequently associated with these two diseases; however, it is likely that other genes, particularly those involved with immunoregulation, also contributed to her susceptibility to these diseases. The association of MS and autoimmune renal disease may be more common than currently recognized.
Royal Brisbane Hospital, Queensland, Herston, Australia.
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RD
Henderson
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D
Saltissi
M P
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Pender
D000328:Adult; D019867:Anti-Glomerular Basement Membrane Disease / Q000150:complications* / Q000235:genetics; D005260:Female; D006680:HLA Antigens / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D009103:Multiple Sclerosis / Q000150:complications* / Q000235:genetics
D006680:HLA Antigens