Histopathological and immunohistochemical studies of intracranial nervous-system tumours in four cattle.
Intracranial nervous-system tumours were diagnosed in three of 1092 bovine necropsy specimens submitted to the Department of Veterinary Pathology, Obihiro University between April 1983 and March 1996. A fourth case was a referral from the Department of Veterinary Pathology, Rakuno Gakuen University. Histopathological examination revealed four types of tumour: intracranial malignant peripheral nerve sheath tumour (MPNST), choroid plexus papilloma, differentiated fibrillary astrocytoma and anaplastic (malignant) astrocytoma. Immunohistochemically, the intracranial MPNST was strongly positive for S-100 protein and vimentin, and in places weakly positive for glial fibrillary acid protein (GFAP). The choroid plexus papilloma was strongly positive for epithelial membrane antigen (EMA), keratin, S-100 protein and vimentin, and positive for GFAP in places. The cytoplasm and fibrous component in the differentiated fibrillary astrocytoma were strongly positive for S-100 protein and GFAP. The anaplastic (malignant) astrocytoma was strongly positive for vimentin, S-100 protein and keratin in the cytoplasm and fibrous processes, and weakly positive for GFAP and EMA in places. Myelin basic protein (MBP) and synaptophysin showed a weak positive reaction in the marginal areas of the tumour.
Department of Veterinary Pathology, Obihiro University of Agriculture and Veterinary Medicine, Japan.
M
M
Yamada
M
M
Nakagawa
M
M
Yamamoto
H
H
Furuoka
T
T
Matsui
H
H
Taniyama
D000818:Animals; D001254:Astrocytoma / Q000737:chemistry / Q000473:pathology / Q000662:veterinary; D001932:Brain Neoplasms / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*; D002417:Cattle; D002418:Cattle Diseases / Q000378:metabolism / Q000473:pathology*; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D005909:Glioblastoma / Q000737:chemistry / Q000473:pathology / Q000662:veterinary; D005910:Glioma / Q000737:chemistry / Q000473:pathology / Q000662:veterinary; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D018396:Mucin-1 / Q000032:analysis; D004676:Myelin Basic Protein / Q000032:analysis; D018317:Nerve Sheath Neoplasms / Q000473:pathology / Q000662:veterinary; D009418:S100 Proteins / Q000032:analysis; D014746:Vimentin / Q000032:analysis
D005904:Glial Fibrillary Acidic Protein; D018396:Mucin-1; D004676:Myelin Basic Protein; D009418:S100 Proteins; D014746:Vimentin; D007633:Keratins