Cord blood transplantation (CBT) in hemoglobinopathies. Eurocord.
Patients with beta-thalassemia (Hbeta th) and sickle cell anemia (SCA) can be treated with bone marrow transplantation. Stem cells from cord blood have several theoretical advantages, however, the place of cord blood transplant for hemoglobinopathies has not yet been established. We report here the EUROCORD experience of 10 patients (Hbeta th = 7, SCA = 3) transplanted with related cord blood.
Miniero
R
R
Eurocord Transplant Registry, Unité de Recherche, Hôpital Saint-Louis, Paris, France.
Rocha
V
V
Saracco
P
P
Locatelli
F
F
Brichard
B
B
Nagler
A
A
Roberts
I
I
Yaniv
I
I
Beksac
M
M
Bernaudin
F
F
Gluckman
E
E
D000755:Anemia, Sickle Cell / Q000628:therapy*; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D016572:Cyclosporine / Q000627:therapeutic use; D005260:Female; D005312:Fetal Blood; D006086:Graft vs Host Disease / Q000517:prevention & control; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D011446:Prospective Studies; D013852:Thiotepa / Q000627:therapeutic use; D016896:Treatment Outcome; D017086:beta-Thalassemia / Q000628:therapy*
D018906:Antineoplastic Agents, Alkylating; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D013852:Thiotepa; D008727:Methotrexate