Evidence of differential mycobacterial growth and modulation of mycobactericidal property by glucoaminylmuramyl dipeptide in murine macrophages.
These results show that given a source of mouse tissue macrophage, there is differential mycobacterial growth with different species of mycobacteria. This suggests that each species of mycobacteria generates a differential response in a given tissue macrophage within the same host for its survival. For example, BCG-P growth becomes permissive in the presence of GMDP in splenic and peritoneal macrophages. Whereas in the same tissue M. tuberculosis growth becomes non-permissive. From Table 2 it is evident that inhibition of inflammatory responses following M. tuberculosis infection leads to reduction of viable organisms in murine macrophages.
Venkataprasad
N
N
Medical Research Council, Tuberculosis and Related Infections Unit, Hammersmith Hospital, London, United Kingdom. nvenkata@rpms.ac.uk
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D002448:Cell Adhesion; D002460:Cell Line; D002478:Cells, Cultured; D005260:Female; D007700:Kinetics; D008264:Macrophages / Q000187:drug effects / Q000382:microbiology / Q000502:physiology*; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000382:microbiology / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009169:Mycobacterium tuberculosis / Q000254:growth & development; D010587:Phagocytosis; D013045:Species Specificity; D013154:Spleen / Q000502:physiology; D013481:Superoxides / Q000378:metabolism
D000276:Adjuvants, Immunologic; D013481:Superoxides; D000119:Acetylmuramyl-Alanyl-Isoglutamine; C063429:glucosaminylmuramyl-2-alanine-D-isoglutamine