A patient with non-A, non-B, non-C hepatitis-associated aplastic anemia recovered promptly following immuno-suppressive therapy, including antithymocyte globulin.
A 21-year-old male patient with non-A, non-B, non-C acute hepatitis was complicated by hepatitis-associated severe aplastic anemia during hospitalization for active hepatitis. He was promptly diagnosed and treated with methylprednisolone, anabolic steroids, cyclosporin A, granulocyte colony-stimulating factor (G-CSF), and antithymocyte globulin (ATG). He responded quickly to the immuno-suppressive therapy and was transfusion independent after 25 days and granulocyte colony-stimulating factor independent at 57 days after ATG therapy. Although the etiology of hepatitis-associated aplastic anemia is still controversial, the authors emphasized the importance to carefully follow non-A, non-B, non-C hepatitis patients without aplastic anemia for more than three months after hepatitis episodes in order to improve outcome of this lethal disease.
Kayashima
S
S
Department of Internal Medicine, Japan Self-Defence Forces Central Hospital, Tokyo, Japan.
Kondou
T
T
Watanabe
Y
Y
Kobari
S
S
Kagami
M
M
D000328:Adult; D000741:Anemia, Aplastic / Q000209:etiology / Q000628:therapy*; D000961:Antilymphocyte Serum / Q000627:therapeutic use*; D001327:Autoimmune Diseases / Q000209:etiology / Q000628:therapy*; D001854:Bone Marrow Cells / Q000276:immunology; D003131:Combined Modality Therapy; D016572:Cyclosporine / Q000627:therapeutic use; D017707:Erythrocyte Transfusion; D019695:Glycyrrhizic Acid / Q000627:therapeutic use; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006525:Hepatitis, Viral, Human / Q000150:complications* / Q000276:immunology; D006801:Humans; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016131:Lymphocyte Subsets / Q000276:immunology; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D010110:Oxymetholone / Q000627:therapeutic use; D017713:Platelet Transfusion
D000961:Antilymphocyte Serum; D007166:Immunosuppressive Agents; D016179:Granulocyte Colony-Stimulating Factor; D019695:Glycyrrhizic Acid; D016572:Cyclosporine; D010110:Oxymetholone; D008775:Methylprednisolone