The immunological properties of cord blood: overview of current research presented at the 2nd EUROCORD workshop.
It is generally agreed that cord blood (CB) transplantation represents an encouraging alternative to bone marrow (BM) transplantation. There are a variety of reasons for this, the two most controversial being (1) whether there is less graft-versus-host disease with CB compared to BM transplantation and (2) whether we can use more HLA mismatches with CB transplantation? If these are true then CB may generate a lower 'immunological response' compared to transplantation with adult cells. Why this may be is unknown, however, recently there has been much work which compared the immunological function of CB and adult monocytes. Here, we highlight the major contributions from 'The Immunological Properties of CB' session at the 2nd EUROCORD workshop which tried to determine why the immunological response in CB may be lower than that of the adult.
Cohen
S B
SB
The Anthony Nolan Research Institute, Department of Haematology, The Royal Free Hospital, London, UK.
Dominiguez
E
E
Lowdell
M
M
Madrigal
J A
JA
D000328:Adult; D017209:Apoptosis / Q000276:immunology; D016026:Bone Marrow Transplantation / Q000276:immunology; D005062:European Union; D005260:Female; D005312:Fetal Blood / Q000276:immunology*; D006086:Graft vs Host Disease / Q000276:immunology / Q000517:prevention & control; D018380:Hematopoietic Stem Cell Transplantation; D006650:Histocompatibility Testing; D006801:Humans; D007108:Immune Tolerance; D007231:Infant, Newborn; D007375:Interleukin-1 / Q000097:blood; D008214:Lymphocytes / Q000276:immunology; D011247:Pregnancy
D007375:Interleukin-1