Hemostasis in acquired hemophilia--role of intracavitary instillation of EACA.
An 82 year old man developed antibodies against coagulation factor VIII:C without any apparent cause. Bleeding from the soft tissue cavity could not be controlled by factor VIII:C concentrates, immunosuppression with steroids and intravenous immunoglobulin therapy in the standard dosages. However, a single injection of Epsilon Aminocaproic Acid (EACA) instilled into the cavity under aseptic precautions achieved lasting hemostasis with resultant wound healing.
Sahu
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S
Department of Dr J C Patel Hematology, KEM Hospital, Parel, Mumbai.
Raipancholia
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R
Pardiwalla
F K
FK
Pathare
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AV
D000368:Aged; D000369:Aged, 80 and over; D015119:Aminocaproic Acid / Q000627:therapeutic use*; D000933:Antifibrinolytic Agents / Q000627:therapeutic use*; D001323:Autoantibodies / Q000276:immunology*; D005169:Factor VIII / Q000276:immunology*; D006467:Hemophilia A / Q000150:complications* / Q000276:immunology; D006470:Hemorrhage / Q000188:drug therapy* / Q000209:etiology*; D006801:Humans; D007322:Instillation, Drug; D008297:Male
D000933:Antifibrinolytic Agents; D001323:Autoantibodies; D005169:Factor VIII; D015119:Aminocaproic Acid