Testing of SOS induction of artificial polycyclic musk fragrances in E. coli PQ37 (SOS chromotest).
Synthetic fragrances are widespread in the environment. Residues were found in animals, human tissues and breast milk. Therefore, six artificial polycyclic musk fragrances--Galaxolide, Tonalide, Celestolide, Phantolide, Cashmeran and Traseolide--were tested for SOS induction using the Escherichia coli PQ37 genotoxicity assay (SOS chromotest) in the presence (+S9) and absence (-S9) of an exogenous metabolizing system. All compounds tested exhibited no SOS inducing potency with the SOS chromotest. These results could be rated as one indicator of the biological inactivity of this group of compounds with respect to genotoxicity.
Institute of Medical Microbiology and Hygiene, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Germany.
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Mersch-Sundermann
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Kevekordes
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Jenter
D000469:Alkaline Phosphatase / Q000096:biosynthesis / Q000235:genetics; D004249:DNA Damage; D004269:DNA, Bacterial / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D010476:Perfume / Q000633:toxicity*; D011084:Polycyclic Aromatic Hydrocarbons / Q000633:toxicity*; D001616:beta-Galactosidase / Q000096:biosynthesis / Q000235:genetics
D004269:DNA, Bacterial; D009153:Mutagens; D010476:Perfume; D011084:Polycyclic Aromatic Hydrocarbons; D000469:Alkaline Phosphatase; D001616:beta-Galactosidase