Microvasculopathy is associated with the number of cerebrovascular lesions in hereditary cerebral hemorrhage with amyloidosis, Dutch type.
OBJECTIVE
Microvascular changes such as microaneurysms and fibrinoid necrosis have been found in the presence of cerebral amyloid angiopathy (CAA). These CAA-associated microvasculopathies (CAA-AM) may contribute to the development of CAA-associated hemorrhages and/or infarcts, hereafter referred to as "cerebrovascular lesions." Hereditary cerebral hemorrhage with amyloidosis, Dutch type (HCHWA-D) is an autosomal dominant form of CAA, in which the amyloid angiopathy is pathologically and biochemically similar to sporadic CAA associated with aging and Alzheimer disease. To determine the significance of CAA-AM for CAA-associated cerebrovascular complications, we investigated the association between CAA-AM and cerebrovascular lesions in HCHWA-D patients.


METHODS
In a previous autopsy study we semiquantitatively scored CAA-AM in 29 HCHWA-D patients. In the present study we reviewed clinical charts and autopsy protocols of these same patients. We investigated whether CAA-AM was associated with age at death, number of cerebrovascular lesions, duration of clinical illness, hypertension, and atherosclerosis.


RESULTS
An association was found between CAA-AM and the number of cerebrovascular lesions (P = 0.009). The presence of microaneurysmal degeneration was most strongly associated with the number of cerebrovascular lesions (P < 0.001). In addition, we found an association between atherosclerosis and the CAA-AM score (P = 0.047). Hypertension was not associated with CAA-AM.


CONCLUSIONS
Our findings support previous reports suggesting an important role of secondary microvascular degenerative changes in CAA-associated cerebrovascular lesions and suggest an aggravating effect of systemic atherosclerosis, but not hypertension, on the evolution of CAA-AM. These findings may be of relevance to understanding cerebrovascular complications of sporadic or Alzheimer disease-associated CAA.
Department of Neurology, Leiden University Medical Center, Netherlands.
R
R
Natté
H V
HV
Vinters
M L
ML
Maat-Schieman
M
M
Bornebroek
J
J
Haan
R A
RA
Roos
S G
SG
van Duinen
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001161:Arteriosclerosis / Q000150:complications / Q000473:pathology; D001921:Brain / Q000098:blood supply*; D002196:Capillaries / Q000473:pathology; D016657:Cerebral Amyloid Angiopathy / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D002543:Cerebral Hemorrhage / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D002561:Cerebrovascular Disorders / Q000209:etiology / Q000235:genetics / Q000473:pathology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000473:pathology; D002532:Intracranial Aneurysm / Q000150:complications / Q000473:pathology; D008297:Male; D008833:Microcirculation; D008875:Middle Aged