[Localization of putative elements of 5'-region of human tyrosine aminotransferase gene mediating its expression by glucocorticoids].
The sequence of the region from -1990 to -580 bp of the human tyrosine aminotransferase gene was determined. Computer analysis revealed putative binding sites for the glucocorticoid-receptor complex which mediates regulation of expression of the gene.
Morozov
I V
IV
Novosibirsk Institute of Bioorganic Chemistry, Siberian Division, Russian Academy of Sciences, Russia. mor@niboch.nsc.ru
Smagulova
F O
FO
Mertvetsov
N P
NP
D001483:Base Sequence; D001665:Binding Sites; D003001:Cloning, Molecular; D003198:Computer Simulation; D004247:DNA / Q000737:chemistry; D004587:Electrophoresis, Agar Gel; D015971:Gene Expression Regulation, Enzymologic; D005938:Glucocorticoids / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011965:Receptors, Glucocorticoid / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism; D012091:Repetitive Sequences, Nucleic Acid; D014444:Tyrosine Transaminase / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism
D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid; D004247:DNA; D014444:Tyrosine Transaminase