Design, construction and use of a large-sample field-cycled PEDRI imager.
The design, construction and use of a large-scale field-cycled proton-electron double-resonance imaging (FC-PEDRI) imager is described. The imager is based on a whole-body sized, vertical field, 59 mT permanent magnet. Field cycling is accomplished by the field compensation method, and uses a secondary, resistive magnet with an internal diameter of 52 cm. The magnetic field can be switched from zero to 59 mT or vice versa in 40 ms. It is used with a double-resonance coil assembly (NMR/EPR) comprising a solenoidal NMR transmit/receive coil and a coaxial, external birdcage resonator for EPR irradiation. Experiments to image the distribution of an exogenous nitroxide free radical in anaesthetized rabbits are described.
Lurie
D J
DJ
Department of Biomedical Physics and Bioengineering, University of Aberdeen, Foresterhill, UK.
Foster
M A
MA
Yeung
D
D
Hutchison
J M
JM
D000818:Animals; D055592:Biophysical Phenomena; D001703:Biophysics; D003497:Cyclic N-Oxides; D004578:Electron Spin Resonance Spectroscopy / Q000295:instrumentation*; D004583:Electrons; D004867:Equipment Design; D005609:Free Radicals / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation*; D011522:Protons; D011817:Rabbits; D011846:Radio Waves; D051381:Rats; D013113:Spin Labels
D003497:Cyclic N-Oxides; D005609:Free Radicals; D011522:Protons; D013113:Spin Labels; C001803:tempol