Investigation into the effect of proteoglycan molecules on the tribological properties of cartilage joint tissues.
The aim of this research was to investigate the role of the hydrophilic properties of the proteoglycan molecules within the cartilage matrix, on the tribological properties of joint tissues in the mixed and boundary lubricating regime. Bovine articular cartilage, bovine meniscus and bovine cartilage that had been degraded to remove the chondroitin sulphate from its proteoglycans were studied in order to investigate differences in their friction and compression responses. The tissues were tested on a sliding friction rig under nominal contact stresses of 0.5 and 4 MPa. The compression tests were carried out under a 0.8 MPa contact stress. The compression tests showed the cartilage and meniscus deforming at the same rates, but the degraded cartilage deformed more quickly to reach its equilibrium position in a shorter period of time. The friction tests carried out at a constant load revealed the friction of the meniscus rising more rapidly with loading time than the cartilage. The degraded cartilage followed an almost identical curve as the untreated cartilage. Although the reduced proteoglycan content of the degraded cartilage substantially altered the biphasic compression response, it did not have an effect on the frictional properties of the tissue.
Pickard
J
J
Biomedical Engineering Research Group, Mechanical Engineering Department, University of Leeds.
Ingham
E
E
Egan
J
J
Fisher
J
J
D000818:Animals; D002138:Calibration; D002358:Cartilage, Articular / Q000737:chemistry / Q000378:metabolism*; D002417:Cattle; D002809:Chondroitin Sulfates / Q000032:analysis; D002858:Chromium Alloys; D017276:Friction; D066298:In Vitro Techniques; D008153:Lubrication; D008592:Menisci, Tibial / Q000378:metabolism; D011312:Pressure; D011509:Proteoglycans / Q000032:analysis / Q000378:metabolism*; D013314:Stress, Mechanical; D013499:Surface Properties; D014159:Transducers; D016474:Weight-Bearing
D002858:Chromium Alloys; D011509:Proteoglycans; D002809:Chondroitin Sulfates