[Toxic psychoses from atropine and scopolamine].
Psychoses caused by an intoxication with atropine or scopolamine are rarely published. Nevertheless atropine and scopolamine were being used in the ancient civilisations and are still in use today. The intoxication is characterised by dose-dependent and substance-dependent syndrome with specific central and peripheral symptoms. Atropine and scopolamine cause a central and peripheral anticholinergic blockade of the muscarine receptor. Psychiatric symptoms include restlessness, excitement, hallucinations, euphoria, disorientation but also stupor, coma and respiratory depression. History, pathophysiology and clinical symptoms of the intoxication due to the alkaloids of the solanaceae are presented. A review of literature is given and four own cases observed in one year are introduced.
Müller
J
J
Integrierter forensisch-psychiatrischer Dienst der Universität Bern Universitätsnervenklinik Psychiatrie-Psychotherapie Homburg/Saar.
Wanke
K
K
D001285:Atropine / Q000009:adverse effects*; D006801:Humans; D018727:Muscarinic Antagonists / Q000009:adverse effects*; D011605:Psychoses, Substance-Induced / Q000523:psychology*; D012601:Scopolamine / Q000009:adverse effects*
D018727:Muscarinic Antagonists; D001285:Atropine; D012601:Scopolamine