Levels of cotinine associated with long-term ad-libitum nicotine polacrilex use in a clinical trial.
Studies of nicotine replacement by 2 mg nicotine polacrilex gum (NG) have typically found that one half to one third of plasma nicotine in recent smokers is replaced. This 5-year study sought to find the extent of nicotine replacement among ex-smokers in the longer term and to identify a mechanism for this relationship. The sample was the special intervention group (N = 3923) in the Lung Health Study, a controlled clinical trial involving smoking cessation. The extent of nicotine replacement was assessed by levels of salivary cotinine. Cotinine levels of ex-smokers using NG after 1 year (219 +/- 149 ng/ml) were similar to those in continuing smokers (290 +/- 159 ng/ml). After 5 years, cotinine levels were the same for NG-using ex-smokers (316 +/- 276 ng/ml), NG-using smokers (309 +/- 240 ng/ml), and NG-non-using smokers (311 +/- 198 ng/ml). Salivary cotinine among NG users at 1 year was only weakly correlated with baseline cotinine levels prior to smoking cessation. Although NG users appear to re-establish cotinine levels characteristic of their smoking, the mechanism by which this occurs remains unclear.
Alcohol and Tobacco Research Unit, University of Manitoba, Winnipeg, Canada. rmurray@hsc.mb.ca
R P
RP
Murray
M A
MA
Nides
J A
JA
Istvan
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K
Daniels
D000328:Adult; D000697:Central Nervous System Stimulants / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002638:Chewing Gum; D003367:Cotinine / Q000493:pharmacokinetics*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D009538:Nicotine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D011109:Polymethacrylic Acids / Q000008:administration & dosage* / Q000493:pharmacokinetics; D011145:Polyvinyls / Q000008:administration & dosage* / Q000493:pharmacokinetics; D012463:Saliva / Q000378:metabolism; D016540:Smoking Cessation; D061485:Tobacco Use Cessation Devices
D000697:Central Nervous System Stimulants; D002638:Chewing Gum; D011109:Polymethacrylic Acids; D011145:Polyvinyls; D009538:Nicotine; D003367:Cotinine