[Intrahepatic arterial infusion chemotherapy with angiotensin II for liver metastasis from gastric cancer].
The theoretical purpose of induced hypertensive chemotherapy used together with injection of Angiotensin II is to increase the delivery of anticancer drug to the target tumor tissue by increasing blood flow in the tumor. Angiotensin II (50 micrograms) was dissolved in 50 ml of normal saline, and given through a peripheral vein by a microinfusion pump. When systolic pressure rose to about 140 to 150 mmHg, mitomycin C (10 to 20 mg/body) was given for 10 minutes via implanted port, whose tip was located in hepatic artery, followed by continuous infusion of 5-FU at 250 mg/day for 5 days. Response could be measured in 7 of all 10 cases (70.0%), CR was found in 4 and PR in 3. As for complications, one case of pseudo-aneurysm and one case of bile duct necrosis owing to drug toxicity were observed. Bone metastases or carcinomatous peritonitis occurred after a few months in two CR cases. We concluded that this mode of chemotherapy was a useful measure for the treatment of liver metastases from gastric cancer.
Dept. of Surgery, Tokyo Metropolitan Komagome Hospital.
Y
Y
Iwasaki
M
M
Kitamura
K
K
Arai
D000368:Aged; D000804:Angiotensin II / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000556:secondary* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000473:pathology*
D000804:Angiotensin II; D016685:Mitomycin; D005472:Fluorouracil