Cytochromes P450 in fungi.
The article gives an overview on the history of the discovery of P450 cytochromes and on their occurrence in nature, especially on their interactions with metabolic pathways in fungi. The significance of the P450 cytochromes in the ergosterol synthesis as well as in the inhibitory mechanisms caused by imidazole and triazole antimycotics is described in detail.
Department of Anti-infectives Research, Janssen Research Foundation, Beerse, Belgium.
H
H
Vanden Bossche
L
L
Koymans
D000595:Amino Acid Sequence; D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry / Q000378:metabolism*; D005658:Fungi / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D051381:Rats; D012441:Saccharomyces cerevisiae / Q000201:enzymology; D013261:Sterols / Q000096:biosynthesis
D000935:Antifungal Agents; D013261:Sterols; D003577:Cytochrome P-450 Enzyme System