Use of the Malthus-AT system to assess the efficacy of permeabilizing agents on the activity of antibacterial agents against Pseudomonas aeruginosa.
The Malthus-AT system provided a satisfactory method for examining the effects of permeabilizing agents on the activity of sub-inhibitory concentrations of antibacterial agents against Pseudomonas aeruginosa G48. Under this system, disodium edetate potentiated the activity of chlorhexidine diacetate (CHA), cetylpyridinium chloride, para-chlorometaxylenol and triclosan. Nitrilotriacetic acid enhanced the activity of some of the antibacterials tested, whereas sodium polyphosphate markedly reduced the efficacy of CHA.
Ayres
H M
HM
Welsh School of Pharmacy, University of Wales Cardiff, UK.
Payne
D N
DN
Furr
J R
JR
Russell
A D
AD
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002463:Cell Membrane Permeability / Q000187:drug effects*; D019343:Citric Acid / Q000494:pharmacology; D004357:Drug Synergism; D004492:Edetic Acid / Q000494:pharmacology*; D004553:Electric Conductivity; D009571:Nitrilotriacetic Acid / Q000494:pharmacology*; D010710:Phosphates / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D013644:Tartrates / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D010710:Phosphates; D013644:Tartrates; D019343:Citric Acid; D004492:Edetic Acid; D009571:Nitrilotriacetic Acid; C018279:sodium phosphate; C029768:tartaric acid