9-Hydroxycrisamicin A, a new cytotoxic isochromanquinone antibiotic produced by Micromonospora sp. SA246.
9-Hydroxycrisamicin A, a new cytotoxic isochromanquinone antibiotic, was isolated from a soil microorganism SA246 which was identified as Micromonospora sp. The molecular formula of 9-hydroxycrisamicin A was determined as C32H22O13 based on the HRFAB-MS analysis, and the structure was determined by various NMR experiments. 9-Hydroxycrisamicin A showed weak antimicrobial activity against Gram-positive bacteria and strong cytotoxic activity against some human cancer cell lines such as SK-OV-3 (ovarian), HCT15 (colon), SK-MEL-2 (melanoma), A549 (lung), XF498 (central nervous system) with ED50 of 0.47-0.65 microgram/ml.
Yeo
W H
WH
Korea Ginseng & Tobacco Research Institute, Taejon, Korea.
Yun
B S
BS
Back
N I
NI
Kim
Y H
YH
Kim
S S
SS
Park
E K
EK
Whang
K S
KS
Yu
S H
SH
D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D005285:Fermentation; D006801:Humans; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008847:Micromonospora / Q000145:classification / Q000378:metabolism*; D009285:Naphthoquinones / Q000302:isolation & purification; D012988:Soil Microbiology; D014407:Tumor Cells, Cultured / Q000187:drug effects
C114119:9-hydroxycrisamicin A; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D009285:Naphthoquinones