Plasma antioxidants and lipid peroxidation in acute myocardial infarction and thrombolysis.
OBJECTIVE
The aim of this study was to investigate the balance between prooxidative and protective mechanisms in patients with acute myocardial infarction (AMI) throughout streptokinase (STK) therapy.


METHODS
Patients who presented to coronary care unit within 3 hours of infarction were followed. Blood was collected before, 2 and 24 hours post STK. Plasma lipid peroxidation was analyzed by a free radical generating system (AAPH) and malondialdehyde equivalents and conjugated dienes quantitated. Plasma vitamins A, E and beta-carotene, were analyzed by HPLC. Patients' results were compared with those from age-matched, healthy control subjects.


RESULTS
In 38 patients with AMI, baseline plasma antioxidant vitamin concentration was reduced compared with a healthy control group. Upon STK therapy, there was a significant drop in plasma vitamin E concentration. Successful reperfusion was followed by an increased plasma oxidizability. Plasma lipids were not significantly different in the AMI patients except for a lower HDL-cholesterol concentration.


CONCLUSIONS
Patients with AMI showed a drop in plasma antioxidant vitamins. Upon thrombolysis, there was an enhanced lipid peroxidation. These alterations indicate the significance of free radical generation processes in reperfusion injury in AMI patients, and suggest the potential involvement of antioxidants in the management of AMI treated by thrombolysis.
Lipid Research Unit, Rambam Medical Center, Haifa, Israel.
Y
Y
Levy
P
P
Bartha
A
A
Ben-Amotz
J G
JG
Brook
G
G
Dankner
S
S
Lin
H
H
Hammerman
D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000188:drug therapy; D015425:Myocardial Reperfusion; D013300:Streptokinase / Q000627:therapeutic use*; D015912:Thrombolytic Therapy
D000975:Antioxidants; D003402:Creatine Kinase; D013300:Streptokinase