Chronic intractable epilepsy associated with a tumor located in the central region: functional mapping data and postoperative outcome.
Out of 57 patients operated for intractable epilepsy of the central region, 8 harbored an indolent glioma (7 dysembryoplastic neuroepithelial tumors, 1 ganglioglioma). Mapping of the sensorimotor area with depth electrodes implanted for stereoelectroencephalographic exploration demonstrated no or abnormal motor responses after low-frequency stimulation, and variable sensory responses to high-frequency stimulation, suggesting reorganization of the sensorimotor cortex representation around the tumor and absence of functional tissue within the neoplastic volume. After lesionectomy (3 cases) or corticectomy including the tumor (5 cases), 6 (75%) patients were seizure-free (class I of Engel) at the time to follow-up. No permanent motor or sensory deficit was observed in 6 cases. In 2, a mild facial (in 1) and arm (in 1) deficit persisted. It is concluded that the resection of intrinsic low-grade tumors associated with long-standing epilepsy and located in the central region can be associated with excellent seizure outcome and no or minimal postoperative deficit because of functional reorganization of the sensorimotor cortex.
Devaux
B
B
Department of Neurosurgery, Sainte-Anne Hospital, Paris, France. devaux@chsa.broca.inserm.fr
Chassoux
F
F
Landré
E
E
Turak
B
B
Daumas-Duport
C
C
Chagot
D
D
Gagnepain
J P
JP
Chodkiewicz
J P
JP
D000293:Adolescent; D000328:Adult; D001931:Brain Mapping; D001932:Brain Neoplasms / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D002540:Cerebral Cortex / Q000503:physiopathology* / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D004567:Electrodes, Implanted; D004827:Epilepsy / Q000209:etiology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D018303:Ganglioglioma / Q000150:complications / Q000175:diagnosis / Q000601:surgery; D005910:Glioma / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D006801:Humans; D008297:Male; D009044:Motor Cortex / Q000503:physiopathology; D013003:Somatosensory Cortex / Q000503:physiopathology; D016896:Treatment Outcome