Hypertrophic cardiomyopathy with type I CD36 deficiency.
CD36 is a multifunctional membrane-type receptor glycoprotein that reacts with oxidized low-density lipoprotein and long-chain fatty acid (LCFA). A patient presented with hereditary hypertrophic cardiomyopathy (HCM) and type I CD36 deficiency (neither platelets nor monocytes expressed CD36) but showed no myocardial LCFA accumulation. CD36 was expressed in the capillary endothelial cells of the cardiac muscle of a control subject, while the patient's myocardial capillary endothelial cells were completely CD36-negative. These results suggest that type I CD36 deficiency is closely related to hereditary HCM and lack of myocardial LCFA accumulation.
Clinical Pharmacology, Niigata College of Pharmacy, Japan. watanabe@niigata-pharm.ac.jp
K
K
Watanabe
K
K
Toba
Y
Y
Ogawa
M
M
Kodama
S
S
Hirono
Y
Y
Ohkura
H
H
Hanawa
Y
Y
Nakamura
Y
Y
Aoki
I
I
Fuse
Y
Y
Aizawa
S
S
Miyajima
Y
Y
Kusano
T
T
Nagatomo
G
G
Hasegawa
M
M
Naito
D018955:CD36 Antigens / Q000378:metabolism*; D002312:Cardiomyopathy, Hypertrophic / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*
D018955:CD36 Antigens