A synthetic strategy to a new class of cycloalkane ring-fused pyridine nucleosides as potential anti HIV agents.
Condensation of cyanothioacetamide or cyanoacetamide with sodium salts of 2-formyl-1-cycloalkanones afforded the corresponding cycloalkane ring fused pyridine-2(1H)-thiones and -2-pyridones. The latter compounds served as a key intermediates for the synthesis of a new class of cycloalkane ring fused pyridine glycosides.
Chemistry Department, Faculty of Science, Helwan University, Cairo, Egypt.
G E
GE
Elgemeie
A M
AM
Attia
B A
BA
Hussain
D019380:Anti-HIV Agents / Q000138:chemical synthesis*; D003516:Cycloparaffins / Q000138:chemical synthesis*; D015195:Drug Design; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D011725:Pyridines / Q000138:chemical synthesis*
D019380:Anti-HIV Agents; D003516:Cycloparaffins; D011725:Pyridines