Correlation of M235T DNA polymorphism with cardiovascular and endocrine responses during physical exercise in healthy subjects.
In our experiments, we evaluated the possible effect of M235T molecular variant of the angiotensinogen gene on the response to a physical workload. A group of volunteers was composed of healthy male subjects, approximately of the same weight and height, same age and not actively trained. None of these subjects was under any medication. Blood sampling was carried out via an indwelling catheter. Besides blood pressure and heart rate, angiotensin I, angiotensin II, epinephrine and norepinephrine concentrations were measured in the blood. Our results suggest that only the response of diastolic blood pressure during submaximal exercise corresponded to the presence of M235T molecular variant. In all other parameters we found no significant correlation of the response with the M235T molecular variant.
Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Bratislava, Slovak Republic.
O
O
Krizanová
J
J
Koska
M
M
Vigas
R
R
Kvetnanský
D000328:Adult; D000808:Angiotensinogen / Q000097:blood*; D000809:Angiotensins / Q000097:blood; D001794:Blood Pressure / Q000502:physiology; D002320:Cardiovascular Physiological Phenomena; D004703:Endocrine System / Q000502:physiology*; D004837:Epinephrine / Q000097:blood; D015444:Exercise / Q000502:physiology*; D005819:Genetic Markers / Q000235:genetics*; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000235:genetics; D008297:Male; D009638:Norepinephrine / Q000097:blood; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*
D000809:Angiotensins; D005819:Genetic Markers; D000808:Angiotensinogen; D009638:Norepinephrine; D004837:Epinephrine