How do histone acetyltransferases select lysine residues in core histones?
Acetylation of specific lysines of core histone N-terminal tails correlates with chromatin assembly and specific regulation of gene expression. Core histones acetylated at particular lysines mediate effects on chromatin function; however, the manner in which different histone acetyltransferases (HATs) discriminate lysines is unknown. Here we propose a putative rule for lysine selection by HATs based on the primary sequence in the vicinity of lysines in the core histone N-terminal tails and in flanking sequence. This provides insight into the molecular basis of site selection of core histones by HATs.
Department of Cellular Biology, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan.
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Kimura
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Horikoshi
D000107:Acetylation; D000123:Acetyltransferases / Q000378:metabolism*; D000595:Amino Acid Sequence; D002843:Chromatin / Q000502:physiology; D051548:Histone Acetyltransferases; D006657:Histones / Q000145:classification / Q000378:metabolism*; D006801:Humans; D008239:Lysine / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins; D013379:Substrate Specificity
D002843:Chromatin; D006657:Histones; D029701:Saccharomyces cerevisiae Proteins; D000123:Acetyltransferases; D051548:Histone Acetyltransferases; D008239:Lysine