Malonyl-CoA--regulator of fatty acid oxidation in muscle during exercise.
As muscle goes from a resting state to exercise, the following sequence of events occurs (Figure 5.5): (1) The rise in AMP accompanying contraction allosterically activates AMPK and an AMPK kinase; (2) The activated AMPK kinase phosphorylates and further activates AMPK; (3) The activated AMPK phosphorylates and inactivates ACC; and (4) The consequent decline in malonyl-CoA (product of ACC reaction) relieves inhibition of CPT-1 and allows an increased rate of fatty acid oxidation when fatty acids become available.
Winder
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Department of Zoology, Brigham Young University, Provo, Utah, USA.
D000818:Animals; D015444:Exercise / Q000502:physiology*; D005215:Fasting / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000201:enzymology; D008316:Malonyl Coenzyme A / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism*; D010084:Oxidation-Reduction; D012680:Sensitivity and Specificity
D005227:Fatty Acids; D008316:Malonyl Coenzyme A