[Novel orphan receptor: ROR gamma expressed during adipocyte differentiation].
ROR/RZR family of nuclear orphan receptors is composed of ROR alpha, beta and gamma. ROR alpha has been demonstrated to play important roles in cerebellum development and immune response. In contrast little is reported about the roles of ROR beta and ROR gamma. We show findings about ROR gamma adipocytes. The expression of ROR gamma is induced in the middle stage of adipocyte differentiation and strongly induced by several ligands for PPAR gamma or overexpression of PPAR gamma. Rev-ErbA competitively antagonizes ROR gamma dependent transcriptional activity on the same response element. Cross-talk among ROR and Rev-Erb is speculated to organize the control of genes associated with adipocytes. In this minireview we summarized our current knowledge on the RORs family and discussed roles of ROR gamma in adipocytes.
Department of Medicine II, Osaka University Medical School.
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Kurebayashi
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Hirose
D017667:Adipocytes / Q000166:cytology*; D000818:Animals; D002454:Cell Differentiation; D006801:Humans; D008024:Ligands; D018168:Receptors, Retinoic Acid / Q000502:physiology*; D000072482:Retinoic Acid Receptor alpha; D000097768:Retinoic Acid Receptor gamma
D008024:Ligands; D018168:Receptors, Retinoic Acid; D000072482:Retinoic Acid Receptor alpha; D000097768:Retinoic Acid Receptor gamma; C000607071:RARA protein, human