The ARF family of transcription factors and their role in plant hormone-responsive transcription.
Auxin response factors or ARFs are a recently discovered family of transcription factors that bind with specificity to auxin response elements (AuxREs) in promoters of primary or early auxin-responsive genes. ARFs have an amino-terminal DNA-binding domain related to the carboxyl-terminal DNA-binding domain in the maize transactivator VIVIPAROUS1. All but one ARF identified to date contain a carboxyl-terminal protein-protein interaction domain that forms a putative amphipathic alpha-helix. A similar carboxyl-terminal protein-protein interaction domain is found in the Aux/IAA class of auxin-inducible proteins. Some ARFs contain transcriptional activation domains, while others contain repression domains. ARFs appear to play a pivotal role in auxin-regulated gene expression of primary response genes.
Department of Biochemistry, University of Missouri, Columbia 65211, USA. bctguilf@muccmail.missouri.edu
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Guilfoyle
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Ulmasov
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Hagen
D017360:Arabidopsis / Q000502:physiology; D004268:DNA-Binding Proteins / Q000737:chemistry; D018506:Gene Expression Regulation, Plant / Q000187:drug effects; D007210:Indoleacetic Acids / Q000494:pharmacology; D010937:Plant Growth Regulators / Q000494:pharmacology*; D010940:Plant Proteins / Q000737:chemistry*; D011401:Promoter Regions, Genetic / Q000235:genetics; D017433:Protein Structure, Secondary; D014157:Transcription Factors / Q000737:chemistry*
D004268:DNA-Binding Proteins; D007210:Indoleacetic Acids; D010937:Plant Growth Regulators; D010940:Plant Proteins; D014157:Transcription Factors