[Erythropoietin as a marker of perinatal risk].
The purpose of this study was to estimate if the erythropoietin (EPO) concentration in cord arterial blood can be an indicator of a fetal risk. We studied EPO concentration measured by enzyme immonoassay in ten patient groups: (1) control group with healthy newborns (n = 72); (2) neonates born by elective caesarean section (n = 16); (3) newborns with acidosis at birth (n = 12); (4) newborns with 1-min-Apgar < 7 (n = 8); (5) preterm neonates (n = 25); (6) newborns with gestational age > or = 242 weeks (n = 19); (7) neonates born to mothers with hypertension (n = 16); (8) newborns with signs of fetal distress in CTG (n = 29); (9) neonates born to mothers with diabetes (n = 19), divided into two subgroups: diabetes White A-D (n = 8) and gestational diabetes (n = 11); (10) neonates born to mothers with diabetes White A-D and with acidosis at birth (n = 7). The geometric mean was 26.4 mU/ml in the control group. EPO levels was found significantly increased (p < 0.01) in the following groups: (3) newborns with acidosis (52 mU/ml); (6) newborns with gestational age > or = 242 weeks (63.5 mU/ml); (8) newborns with signs of fetal distress in CTG (47.1 mU/ml); (9) neonates born to mothers with diabetes White A-D (47.7 mU/ml); (10) neonates born to mothers with diabetes White A-D and with acidosis at birth (> 64 mU/ml). We came to the conclusion that the cord arterial EPO concentration indicates a chronic fetal hypoxia and a longer duration of hypoxia before birth.
Zentrum für Kinderheilkunde, Klinik und Poliklinik für Allgemeine Pädiatrie, Martin-Luther-Universität Halle-Wittenberg.
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D000328:Adult; D001238:Asphyxia Neonatorum / Q000097:blood / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood; D001724:Birth Weight; D002585:Cesarean Section; D004921:Erythropoietin / Q000097:blood*; D005260:Female; D005316:Fetal Distress / Q000097:blood / Q000175:diagnosis*; D005311:Fetal Hypoxia / Q000097:blood / Q000175:diagnosis; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D007752:Obstetric Labor, Premature / Q000097:blood / Q000175:diagnosis*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000097:blood / Q000175:diagnosis; D018566:Pregnancy, High-Risk / Q000097:blood*; D011446:Prospective Studies; D012016:Reference Values
D015415:Biomarkers; D004921:Erythropoietin