Decrease in short-term memory function induced by CCK-4 in healthy volunteers.
The purpose of this study was to assess the effects of continuous intravenous infusion of the central cholecystokinin (CCK) receptor agonist, CCK-4, on short-term memory and psychomotor performance in healthy volunteers in a double-blind, placebo-controlled, parallel group study. Compared to placebo, CCK-4 (0.5 mg/h) significantly impaired performance on free-recall and recognition of words in the middle of the CCK-4 infusion, but did not affect psychomotor acuity. The results of this study indicate that CCK-4 may exert a negative influence on memory consolidation and retrieval.
Stress and Anxiety Clinical Research Unit, Royal Ottawa Hospital, University of Ottawa, Ontario, Canada. jshlik@rohcg.on.ca
J
J
Shlik
D
D
Koszycki
J
J
Bradwejn
D000293:Adolescent; D000328:Adult; D003071:Cognition / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects*; D011597:Psychomotor Performance / Q000187:drug effects; D013758:Tetragastrin / Q000494:pharmacology*
D013758:Tetragastrin