The effect of gamma radiation on Li+ transport through human erythrocyte membranes.
Human erythrocytes were exposed at room temperatures to 662 keV gamma radiation at doses up to 60 Gy. The total delta Li+ influx as well as the delta Li+ influx by passive diffusion and Na(+)-K+ pump mechanisms increased linearly with the dose. The rate constant K of Li+ efflux by the Li(+)-Na+ countertransport mechanism through irradiated erythrocyte membranes was reduced by about 35% at the highest dose.
Institute for Isotopic and Molecular Technology, Cluj-Napoca, Romania.
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D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects*; D005720:Gamma Rays; D006801:Humans; D008094:Lithium / Q000493:pharmacokinetics*; D010042:Ouabain / Q000494:pharmacology; D000254:Sodium-Potassium-Exchanging ATPase / Q000187:drug effects / Q000378:metabolism
D010042:Ouabain; D008094:Lithium; D000254:Sodium-Potassium-Exchanging ATPase