Dynamic analysis of the three-phasic vascular response to histamine in coronary circulation.
In this work we tried to perform a dynamic analysis of coronary vascular response to histamine, using a simple mathematical analysis as a first step in the better understanding of complex histamine effects on coronary blood vessels of the isolated guinea pig heart. So, we defined more parameters, such as: I and delta I to quantify the intensity of coronary perfusion pressure (CPP) change, T and dt to quantify the time CPP change occurs and D to characterize the intensity and duration of CPP change, i.e. to quantify the dynamics of this change.
Institute of Physiology, Faculty of Medicine, University of Kragujevac, Yugoslavia.
G L
GL
Rosić
M
M
Segal
I
I
Andelković
C
C
Collis
D
D
Mitrović
M A
MA
Rosić
D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects* / Q000502:physiology; D003331:Coronary Vessels / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects / Q000502:physiology; D006632:Histamine / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D008954:Models, Biological; D013997:Time Factors
D006632:Histamine