Lymphocyte signalling: a coordinating role for Vav?
Vav1 is a guanine nucleotide exchange factor that selectively activates the Rac1 GTPase and is expressed specifically in haematopoietic cells. Recent work has revealed how Vav1 integrates signals from lymphocyte antigen receptors and costimulatory receptors to control immune function.
Cantrell
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Lymphocyte Activation Laboratory, Imperial Cancer Research Fund, London, UK.
D000199:Actins; D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D018797:Cell Cycle Proteins; D003599:Cytoskeleton / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000502:physiology; D050778:NFATC Transcription Factors; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D051567:Proto-Oncogene Proteins c-vav; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic; D020744:rac GTP-Binding Proteins
D000199:Actins; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D050778:NFATC Transcription Factors; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins; D051567:Proto-Oncogene Proteins c-vav; D014157:Transcription Factors; D019204:GTP-Binding Proteins; D020744:rac GTP-Binding Proteins; D002118:Calcium