[Signal transductions by the MAP kinase cascades].
The classical mitogen-activated protein(MAP) kinase cascade is one of the central intracellular signaling pathways that play a crucial role in cell proliferation, cell differentiation, cell transformation, and many other cellular responses. Two novel MAP kinase cascades, the SAPK/JNK cascade and the p38/MPK2 cascade, were identified, and were shown to function in various stress responses and apoptotic processes. Intracellular distribution of classical MAP kinase kinase (MAPKK/MEK) is regulated by its nuclear export signal (NES) which may function to suppress malignant cell transformation. CRM1 protein has been identified as a receptor for leucine-rich NES. CRM1 binds to CAN/NUP214, one of nucleopore proteins, which has been suggested to be involved in myeloid leukemia. Thus, the nuclear export system may be by somehow related to cancer development.
Gotoh
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I
Department of Biophysics, Graduate School of Science, Kyoto University.
Nishida
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E
D000818:Animals; D001426:Bacterial Proteins; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000502:physiology*; D002352:Carrier Proteins / Q000378:metabolism; D002471:Cell Transformation, Neoplastic; D004720:Endonucleases / Q000378:metabolism; D006801:Humans; D028884:Karyopherins; D020929:Mitogen-Activated Protein Kinase Kinases; D011485:Protein Binding; D011494:Protein Kinases / Q000502:physiology; D018160:Receptors, Cytoplasmic and Nuclear; D015398:Signal Transduction; D000097606:Exportin 1 Protein
D001426:Bacterial Proteins; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D002352:Carrier Proteins; D004720:Endonucleases; D028884:Karyopherins; D020929:Mitogen-Activated Protein Kinase Kinases; D011494:Protein Kinases; D018160:Receptors, Cytoplasmic and Nuclear; D000097606:Exportin 1 Protein; C100898:nes protein, Staphylococcus aureus