Antinociceptive and anti-inflammatory activity of a flavonoid isolated from Caralluma attenuata.
Luteolin-4'-O-neohesperidoside, i.e. luteolin-4'-O-[alpha-(L-rhamnopyranosyl-(1-->2)-beta-D-glucopyranoside)] has significant anti-inflammatory action. It is more potent than ibuprofen. Its antinociceptive activity is less pronounced when compared with its anti-inflammatory activity.
University College of Pharmaceutical Sciences, Kakatiya University, Warangal, India.
M
M
Ramesh
Y N
YN
Rao
A V
AV
Rao
M C
MC
Prabhakar
C S
CS
Rao
N
N
Muralidhar
B M
BM
Reddy
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D005260:Female; D006569:Hesperidin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D047311:Luteolin; D008297:Male; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; C114970:luteolin-4'-O-neohesperidoside; D006569:Hesperidin; D047311:Luteolin