Differences in heart phospholipids in two inbred rat strains differing in sensitivity to the development of heart lesions.
The content of phospholipids and their fatty acid composition were followed in the hearts of two inbred strains of rats: IR, resistant against the development of isoprenaline-induced myocardial lesions and IS, sensitive to their development. In the hearts of rats of the resistant strain, a lower content of phosphatidylcholine and its plasmalogen fraction was found compared to IS rats. The total amount of phospholipids was only insignificantly lower in IR rats. Greater differences were found in individual fatty acids. The most important finding concerned lower arachidonic acid and higher linoleic acid content in heart phospholipids of IR rats. These differences were exactly opposite to changes reported in the literature in animals known to have a higher resistance against myocardial damage due to various interventions. Our results do not support the hypothesis claiming the importance of changes in phospholipids and their FA composition for the resistance of the heart against the development of necrotic lesions.
Institute of Pharmacology, First Faculty of Medicine, Charles University, Prague, Czech Republic.
E
E
Kmonícková
O
O
Nováková
E
E
Tvrzická
M
M
Mráz
S
S
Hynie
D000818:Animals; D009202:Cardiomyopathies / Q000235:genetics*; D005227:Fatty Acids / Q000737:chemistry / Q000378:metabolism; D007545:Isoproterenol / Q000378:metabolism; D019787:Linoleic Acid / Q000378:metabolism; D008563:Membrane Lipids / Q000737:chemistry; D009206:Myocardium / Q000737:chemistry*; D009638:Norepinephrine / Q000378:metabolism; D010713:Phosphatidylcholines / Q000378:metabolism; D010743:Phospholipids / Q000737:chemistry*; D051381:Rats; D011919:Rats, Inbred Strains
D005227:Fatty Acids; D008563:Membrane Lipids; D010713:Phosphatidylcholines; D010743:Phospholipids; D019787:Linoleic Acid; D007545:Isoproterenol; D009638:Norepinephrine