[Fleroxacin treatment for acute uncomplicated cystitis in women: comparison of 3-day and 7-day therapy].
The clinical efficacy of fleroxacin (FLRX), a new fluoroquinolone, for acute uncomplicated cystitis (AUC) in women was assessed. Two regimens, 3-day and 7-day courses of FLRX, 200 mg once a day, were compared. Clinical and bacteriological efficacy were evaluated after the therapy, and recurrence rate was evaluated 1 week and 4 weeks after termination of the therapy. Of 136 registered subjects, 35 in the 3-day group and 47 in the 7-day group were evaluated. According to the criteria of Japanese UTI Committee (3rd edition), the rate of excellent results was significantly higher in the 7-day group (78.9%) than in the 3-day group (48.6%), but the overall clinical efficacy rate was similar being 100% and 97.9%, respectively. Although no recurrence was seen 1 week after the therapy in either group, recurrence was seen in 14.3% and 7.4% of the cases in the 3-day and 7-day groups, respectively, 4 weeks after the therapy. Adverse reactions were observed in 2 and 3 cases in the 3-day and 7-day groups, respectively. Both 3-day and 7-day regimens of FLRX treatment showed good efficacy. Although the 7-day treatment was superior to the 3-day treatment as to high rate of excellent results and low rate of recurrence, the 3-day treatment was concluded to be sufficient for AUC.
Ishihara
S
S
Department of Urology, Gifu University School of Medicine.
Ban
Y
Y
Kawada
Y
Y
Ito
S
S
Ito
Y
Y
Doi
T
T
Nezasa
S
S
Fujihiro
S
S
Yamaha
M
M
Ito
F
F
Iwata
H
H
Hasegawa
Y
Y
Ueno
K
K
Shinoda
I
I
Taniguchi
M
M
Minoshima
K
K
Takeuchi
T
T
Sakai
S
S
Uno
H
H
Koide
T
T
D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D003556:Cystitis / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005260:Female; D016576:Fleroxacin / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D012008:Recurrence
D000890:Anti-Infective Agents; D016576:Fleroxacin