Sequencing-based typing reveals six novel MHC class I chain-related gene B (MICB) alleles.
The MHC class I chain-related gene A (MICA) is highly polymorphic. In this paper we demonstrate polymorphism in the other expressing member of the MIC family of genes: MICB. Using a sequencing-based typing approach on cDNA, analysis of exons 2 through 6 revealed eight polymorphic sites resulting in six unique MICB sequences. Although MICB has high nucleotide homology with MICA, its polymorphism is restricted and at different sites compared to those in MICA.
Department of Immunology and Histocompatibility, Hôpital Saint Louis, Paris, France.
C J
CJ
Visser
M G
MG
Tilanus
V
V
Schaeffer
Z
Z
Tatari
R
R
Tamouza
A
A
Janin
D
D
Charron
D000483:Alleles; D000595:Amino Acid Sequence; D001483:Base Sequence; D001943:Breast Neoplasms / Q000235:genetics; D005091:Exons; D005260:Female; D005805:Genes, MHC Class I; D015789:HLA-A2 Antigen / Q000235:genetics; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D017386:Sequence Homology, Amino Acid
D015789:HLA-A2 Antigen; D015395:Histocompatibility Antigens Class I; C098080:MICB antigen