Radiologic progression in patients with juvenile chronic arthritis treated with methotrexate.
We investigated the rate of radiologic progression, as measured by carpal length, in 26 children with juvenile chronic arthritis who were treated with methotrexate. After 2 years of treatment, the carpal length was significantly more deteriorated in nonresponders in both the "better" wrist (P = .001) and the "worse" wrist (P = .005). These results show that methotrexate may have a "disease modifying" potential in juvenile chronic arthritis.
Clinica Pediatrica dell'Università di Pavia, Italy.
A
A
Ravelli
S
S
Viola
B
B
Ramenghi
G
G
Beluffi
L A
LA
Zonta
A
A
Martini
D000293:Adolescent; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001171:Arthritis, Juvenile / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000503:physiopathology; D002348:Carpal Bones / Q000000981:diagnostic imaging / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007223:Infant; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use*; D011859:Radiography; D012189:Retrospective Studies
D018501:Antirheumatic Agents; D007166:Immunosuppressive Agents; D008727:Methotrexate