Immunohistochemical localization of the epidermal growth factor receptor in normal mouse tissues.
The levels of epidermal growth factor (EGF) receptors were investigated in normal mouse tissues. Two patterns of reactivity were recognized: strong membraneous of diffuse cytoplasmic staining. The basal epithelial cells of the skin and the collecting tubule cells of the kidney showed membraneous reactivity whereas the bronchial epithelial cells, parietal cells of the stomach and tubular cells of the kidney showed cytoplasmic reactivity predominantly with the antibody. The distribution of the epidermal growth factor receptors in different cell types and cellular compartments may implicate varying activation states of the growth factor and its interaction with a milieu available ligand.
Gazi University Faculty of Medicine Department of Histology Embryology, Ankara, Türkiye.
C
C
Ozoğul
E
E
Karaöz
D
D
Erdoğan
G
G
Akyol
D000818:Animals; D001980:Bronchi / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D004847:Epithelial Cells / Q000378:metabolism; D066246:ErbB Receptors / Q000378:metabolism*; D007150:Immunohistochemistry; D007684:Kidney Tubules / Q000378:metabolism; D007685:Kidney Tubules, Collecting / Q000378:metabolism; D008297:Male; D051379:Mice; D010295:Parietal Cells, Gastric / Q000378:metabolism; D012867:Skin / Q000378:metabolism; D014018:Tissue Distribution
D066246:ErbB Receptors