Effects of histamine H1 receptor antagonists on compound 48/80-induced scratching behavior in mice.
The effects of histamine H1 receptor antagonists on compound 48/80-induced scratching behavior were studied in mice. Classical histamine H1 receptor antagonists such as diphenhydramine and chlorpheniramine caused a potent depressant effect on compound 48/80-induced scratching behavior. Histamine H1 receptor antagonists having antiallergic activity (an inhibition of mast cell degranulation), such as azelastine and oxatomide and nonsedative histamine H receptor antagonists such as terfenadine, epinastine and astemizole, also showed a relatively potent effect. On the other hand, the effects of tranilast and cromolyn sodium--antiallergic drugs without histamine H1 receptor antagonistic activity--were extremely weak. Diazepam had weak or no depressant effects on compound 48/80-induced scratching behavior. These results suggest that inhibition of compound 48/80-induced scratching behavior is mainly due to histamine H1 receptor antagonistic activity and not to the sedative action of the drugs.
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Japan.
Y
Y
Sugimoto
K
K
Umakoshi
N
N
Nojiri
C
C
Kamei
D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D000982:Antipruritics / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D015550:Cell Degranulation / Q000187:drug effects; D005260:Female; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D008407:Mast Cells / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D011537:Pruritus / Q000139:chemically induced / Q000188:drug therapy*; D013329:Structure-Activity Relationship; D003189:p-Methoxy-N-methylphenethylamine
D018926:Anti-Allergic Agents; D000982:Antipruritics; D006634:Histamine H1 Antagonists; D003189:p-Methoxy-N-methylphenethylamine