Allogeneic peripheral blood stem cell transplantation for standard-risk leukemia. A multicenter pilot study: Japanese experience. Japan Blood Cell Transplantation Study Group.
A multicenter phase II study of allogeneic peripheral blood stem cell transplantation (allo-PBSCT) was conducted. Twenty-two patients (median age, 36 years) with standard-risk leukemia were transplanted with G-CSF-mobilized PBSC from an HLA-identical sibling donor, and received cyclosporine and methotrexate for GVHD prevention. Median days to ANC >500/microl and platelets >50,000/microl were 12 (9-20) and 16 (11-32), respectively. Grade II-IV acute GVHD developed in 6/21 (29%) and extensive chronic GVHD in 12/20 (60%). These observations indicate that allo-PBSCT is characterized by rapid hematologic engraftment, no increase of acute GVHD and an increased risk of chronic GVHD, and can be used as an alternative to allogeneic bone marrow transplantation.
Department of Internal Medicine II, Okayama University Medical School, Japan.
M
M
Harada
K
K
Shinagawa
T
T
Kawano
M
M
Kasai
H
H
Sawada
S
S
Nakao
H
H
Hyodo
N
N
Aotsuka
T
T
Furukawa
H
H
Hirai
T
T
Eto
Y
Y
Imai
C
C
Shimazaki
K
K
Matsue
M
M
Ogawa
F
F
Takaku
D000293:Adolescent; D000328:Adult; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007564:Japan; D007938:Leukemia / Q000503:physiopathology / Q000628:therapy*; D008875:Middle Aged; D010865:Pilot Projects; D014184:Transplantation, Homologous; D016896:Treatment Outcome