Calcium-sensing by parathyroid glands in secondary hyperparathyroidism.
Calcium-sensing by the parathyroids is abnormal in familial benign hypocalciuric hypercalcemia and in primary hyperparathyroidism (primary HPT), but the role of a calcium-sensing defect in uremic secondary hyperparathyroidism (secondary HPT) remains controversial. To study the regulation of PTH release by calcium, set point estimates were obtained using the four parameter model during in vivo dynamic tests of parathyroid gland function in 31 patients with secondary HPT, 8 patients with advanced secondary HPT studied shortly before undergoing parathyroidectomy (Pre-PTX), 3 patients with primary HPT, and 20 subjects with normal renal function (NL); the response to 2-h i.v. calcium infusions was also evaluated. Neither blood ionized calcium (iCa+2) levels nor the set point for calcium-regulated PTH release differed between secondary HPT and NL; iCa+2 levels and set point values were moderately elevated in Pre-PTX and markedly elevated in primary HPT. Compared with values obtained in NL, the lowest serum PTH levels achieved during calcium infusions, expressed as a percentage of pre-infusion values, were incrementally greater in secondary HPT, Pre-PTX, and primary HPT, whereas the slope of the relationship between iCa+2 and PTH, expressed as the natural logarithm (ln) of percent preinfusion values, decreased incrementally in secondary HPT, Pre-PTX, and primary HPT. The inhibitory effect of calcium on PTH release is blunted both in secondary HPT and primary HPT because of increases in parathyroid gland mass, but a calcium-sensing defect is a late, rather than early, consequence of renal secondary HPT.
Department of Medicine, University of California at Los Angeles School of Medicine, 90095, USA. wgoodman@ucla.edu
W G
WG
Goodman
J D
JD
Veldhuis
T R
TR
Belin
A J
AJ
Van Herle
H
H
Juppner
I B
IB
Salusky
D000293:Adolescent; D000328:Adult; D000368:Aged; D002118:Calcium / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D002648:Child; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000503:physiopathology*; D006962:Hyperparathyroidism, Secondary / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010280:Parathyroid Glands / Q000503:physiopathology*; D010281:Parathyroid Hormone / Q000097:blood / Q000378:metabolism; D016105:Parathyroidectomy; D014511:Uremia / Q000150:complications
D010281:Parathyroid Hormone; D002118:Calcium