Microalbuminuria and cardiovascular risk.
The term 'microalbuminuria' has been introduced to describe a measurable increase in urine albumin excretion, which is still within normal total urine protein excretion levels. Many data suggest that microalbuminuria is of value as an index of vascular damage, especially in hypertension and diabetes, and there is increasing information on its associations with traditional cardiovascular risk factors and its prognostic value. The association between microalbuminuria and peripheral markers of endothelial damage or dysfunction, such as von Willebrand factor, suggests the possibility that microalbuminuria may be a simple, cheap and easy index of endothelial abnormalities in cardiovascular disease. Nevertheless, further information on the value of microalbuminuria in other atherosclerotic vascular complications, such as ischaemic heart disease, stroke and peripheral artery disease is still needed.
Lydakis
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University Department of Medicine, City Hospital, Birmingham, UK. greg@chtmedicine.demon.co.uk
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D000419:Albuminuria / Q000209:etiology*; D015415:Biomarkers / Q000652:urine; D002318:Cardiovascular Diseases / Q000150:complications* / Q000175:diagnosis / Q000652:urine; D048909:Diabetes Complications; D006801:Humans; D006973:Hypertension / Q000150:complications; D007333:Insulin Resistance; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects
D015415:Biomarkers