Speculating about spectrin: new insights into the Golgi-associated cytoskeleton.
Amid the continual flux of membranes and proteins through the Golgi, the distinctive structure and compartmentalization of the cisternal stacks are preserved. Microtubules and associated motors are required to maintain Golgi structure and for transport to and from the organelle. There is also evidence for Golgi-associated myosins. Recent research has identified a novel Golgi-associated spectrin-based network. In this review, we discuss evidence for this network and the possible roles for spectrin in maintaining Golgi structure and in vesicular transport to and from the Golgi. Overall the link between the cytoskeleton and the Golgi appears to be dynamic in nature, in keeping with the continuous flux of proteins and lipids through this organelle.
Cell and Molecular Biology, Graduate Group, University of Pennsylvania, Philadelphia 19104, USA.
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Holleran
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Holzbaur
D000818:Animals; D002460:Cell Line; D003599:Cytoskeleton / Q000378:metabolism / Q000502:physiology*; D006056:Golgi Apparatus / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D013049:Spectrin / Q000378:metabolism / Q000502:physiology*
D013049:Spectrin