Effects of histamine H1 receptor antagonists on compound 48/80-induced scratching behavior in mice.
The effects of histamine H1 receptor antagonists on compound 48/80-induced scratching behavior were studied in mice. Classical histamine H1 receptor antagonists such as diphenhydramine and chlorpheniramine caused a potent depressant effect on compound 48/80-induced scratching behavior. Histamine H1 receptor antagonists having antiallergic activity (an inhibition of mast cell degranulation), such as azelastine and oxatomide and nonsedative histamine H receptor antagonists such as terfenadine, epinastine and astemizole, also showed a relatively potent effect. On the other hand, the effects of tranilast and cromolyn sodium--antiallergic drugs without histamine H1 receptor antagonistic activity--were extremely weak. Diazepam had weak or no depressant effects on compound 48/80-induced scratching behavior. These results suggest that inhibition of compound 48/80-induced scratching behavior is mainly due to histamine H1 receptor antagonistic activity and not to the sedative action of the drugs.
Sugimoto
Y
Y
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Japan.
Umakoshi
K
K
Nojiri
N
N
Kamei
C
C
D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D000982:Antipruritics / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D015550:Cell Degranulation / Q000187:drug effects; D005260:Female; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D008407:Mast Cells / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D011537:Pruritus / Q000139:chemically induced / Q000188:drug therapy*; D013329:Structure-Activity Relationship; D003189:p-Methoxy-N-methylphenethylamine
D018926:Anti-Allergic Agents; D000982:Antipruritics; D006634:Histamine H1 Antagonists; D003189:p-Methoxy-N-methylphenethylamine