Structure-based drug design.
Most of the techniques used in structure-based drug design have experienced significant improvements in the past few years, resulting in a marked enhancement of the speed and the efficacy of this approach. At the same time, it was thought that the future of drug design lay in strategies involving solely combinatorial chemistry. It is becoming evident, however, that the development of future drugs will use a combination of methods that will contain a major component of structure-based design.
Amzel
L M
LM
Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, Md. 21205, USA. mario@neruda.med.jhmi.edu
D016208:Databases, Factual; D015195:Drug Design; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism; D008954:Models, Biological; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism
D008565:Membrane Proteins; D011506:Proteins