The value of 201thallium-SPECT imaging in childhood brainstem gliomas.
OBJECTIVE
To compare 201thallium (T1) uptake and SPECT with MRI in children with brainstem gliomas.


METHODS
Ten children with brainstem gliomas were prospectively evaluated by 201Tl-SPECT and MRI. Histological verification was obtained in eight children - two died prior to surgery. Quantitative thallium uptake index (UI) was obtainable in five cases and was compared to tumour grade. In addition, two patients with known benign brainstem lesions (neurofibromatosis and tuberculoma) were similarly prospectively evaluated.


RESULTS
All children with brainstem glioma accumulated thallium. (Mean U1 3.23, 100% sensitivity). The single patient with brainstem tuberculoma also accumulated thallium (UI 2.80, 91.7% specificity). There was no correlation between thallium uptake and tumour grade. Uptake could not be conclusively correlated with the following MR features: gadolinium enhancement, exophytic or intrinsic gliomas, necrosis and location of glioma within the brainstem.


CONCLUSIONS
201T1-SPECT is a promising imaging adjunct in the assessment of childhood brainstem gliomas.
Department of Neurosurgery, University of Natal, Faculty of Medicine, Wentworth Hospital, Private Bag Jacobs, 4026, Durban, South Africa.
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Nadvi
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Ebrahim
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D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D001933:Brain Stem / Q000000981:diagnostic imaging* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005910:Glioma / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D013793:Thallium; D015899:Tomography, Emission-Computed, Single-Photon
D013793:Thallium