Mycobacterium celatum infection in two HIV-infected patients treated prophylactically with rifabutin.
Mycobacterium celatum is a recently described slow-growing species. It was identified on the basis of genomic sequencing that differentiates three types. The present report describes two cases of Mycobacterium celatum type 1 infection in patients with AIDS. Both patients had CD4+ lymphocyte counts of < 10/mm3, were receiving rifabutin prophylaxis, and had attended the same treatment units. The minimum inhibitory concentration of rifabutin for both strains was 8 mg/l, which may account for the failure of prophylaxis. As all type 1 strains have the same pulsed-field gel electrophoresis pattern, nosocomial transmission or acquisition from a common source could not be ruled out.
Gholizadeh
Y
Y
Laboratoire de Microbiologie, Hôpital Rothschild, Paris, France.
Varnerot
A
A
Maslo
C
C
Salauze
B
B
Badaoui
H
H
Vincent
V
V
Buré-Rossier
A
A
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy* / Q000382:microbiology; D000328:Adult; D000904:Antibiotics, Antitubercular / Q000627:therapeutic use*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D009161:Mycobacterium / Q000187:drug effects; D009164:Mycobacterium Infections / Q000188:drug therapy* / Q000382:microbiology; D017828:Rifabutin / Q000627:therapeutic use*
D000904:Antibiotics, Antitubercular; D017828:Rifabutin