Clinical and economic comparison of lenograstim-primed blood cells (BC) and bone marrow (BM) allogeneic transplantation.
The study presented is a clinical and economic comparison of bone marrow (BM) and blood cells (BC) allogeneic transplantation. We performed a case-control study to compare 17 patients receiving allogeneic BC transplant in a pilot study to an historical group of 17 patients allografted with BM. We evaluated the clinical outcomes and the direct medical costs of transplantation from conditioning regimen until day 100 by detailed observation of patients' medical records. Patients in the BC group received a median of 8 x 10(6)/kg CD34+ cells (1.58-29.1) and 266 x 10(6)/kg CD3+ cells (128-469). All patients had neutrophil engraftment with a median of 14 days in the BC group vs 19 days in the BM group (P < 0.05). The Kaplan-Meier estimation of the median number of days to a platelet count of > 25 x 10(9)/l, independent of platelet transfusion, was significantly shorter in the BC group (15 (9-74)) compared with the BM group (25 (15-45)). Acute graft-versus-host disease (AGVHD) of grade > or = 2 was not significantly different between the two groups. Patients treated with BC presented a US$16,134 decrease in the cost of the first 100 days (29%, P = 0.006). Our comparison suggested that platelet reconstitution and total costs were in favor of the BC group.
Institut Paoli-Calmettes, Regional Center for Cancer Research and Treatment, Marseille, France.
C
C
Faucher
C
C
Fortanier
P
P
Viens
A G
AG
Le Corroller
C
C
Chabannon
J
J
Camerlo
G
G
Novakovitch
J A
JA
Gastaut
D
D
Maraninchi
J P
JP
Moatti
D
D
Blaise
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000328:Adult; D016026:Bone Marrow Transplantation / Q000191:economics; D003365:Costs and Cost Analysis; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology; D019650:Hematopoietic Stem Cell Mobilization / Q000191:economics; D018380:Hematopoietic Stem Cell Transplantation / Q000191:economics; D006801:Humans; D000078224:Lenograstim; D007938:Leukemia / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000494:pharmacology; D014184:Transplantation, Homologous; D016896:Treatment Outcome
D000276:Adjuvants, Immunologic; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D000078224:Lenograstim