YM-32890 A and B, new types of macrolide antibiotics produced by Cytophaga sp.
Two new types of macrolide antibiotics, YM-32890 A and B, have been isolated from the fermentation broth of cytophaga sp. YL-02905S. In this paper, the taxonomy of the producing strain, fermentation, isolation, structure elucidation, and biological activity of the antibiotics are reported. YM-32890 A inhibits the growth of staphylococci including a macrolide-resistant strain, but shows no antimicrobial activity against other Gram-positive, Gram-negative bacteria and yeast.
Microbiology Research Dept. Drug Serendipity Research Labs., Yamanouchi Pharmaceutical Co., Ltd., Tokyo, Japan.
K
K
Kamigiri
T
T
Tokunaga
T
T
Sugawara
K
K
Nagai
M
M
Shibazaki
B
B
Setiawan
R M
RM
Rantiatmodjo
M
M
Morioka
K
K
Suzuki
D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D003589:Cytophaga / Q000378:metabolism*; D005285:Fermentation; D006801:Humans; D018942:Macrolides; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D018942:Macrolides; C114126:YM 32890A; C114127:YM 32890B