Antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis associated with propylthiouracil therapy.
A teenage girl with crescentic glomerulonephritis had antineutrophil cytoplasmic antibody (ANCA) detected after she had received propylthiouracil (PTU) for hyperthyroidism without cutaneous vasculitis. ANCA was detected on admission; renal biopsy showed crescentic glomerulonephritis with focal necrotizing glomerulonephritis but no immune deposits. Administration of steroid and decreasing the dose of PTU produced a good clinical response and the ANCA disappeared. It was concluded that ANCA is closely related to the pathogenesis of crescentic glomerulonephritis and that treatment with PTU appeared to induce ANCA.
Department of Pediatric Nephrology, Tokyo Women's Medical College, Japan.
M
M
Fujieda
M
M
Nagata
Y
Y
Akioka
M
M
Hattori
H
H
Kawaguchi
K
K
Ito
D000293:Adolescent; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D013956:Antithyroid Agents / Q000009:adverse effects*; D005260:Female; D005921:Glomerulonephritis / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology / Q000628:therapy; D005923:Glomerulosclerosis, Focal Segmental / Q000139:chemically induced / Q000276:immunology / Q000473:pathology / Q000628:therapy; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications* / Q000188:drug therapy; D009336:Necrosis; D011441:Propylthiouracil / Q000009:adverse effects*
D019268:Antibodies, Antineutrophil Cytoplasmic; D013956:Antithyroid Agents; D011441:Propylthiouracil