Dermal infiltrate of enlarged macrophages in patients receiving chemotherapy.
A histologically distinct maculopapular eruption has been associated with the use of recombinant forms of granulocyte and granulocyte-macrophage colony-stimulating factors (GCSF and GMCSF). One of the most distinctive features was an increase in the number and the size of dermal macrophages, which was proposed as a clue to diagnosis of these cytokine-induced dermatoses. We describe 8 patients who received chemotherapy and who developed a maculopapular eruption, of which histological examination showed an increase in the number and the size of dermal macrophages. Three patients had also received GM-CSF or G-CSF, before the onset of rash, but 5 patients had not. In conclusion, an increase in the number and the size of dermal macrophages is not specific for the reaction to GM-CSF or G-CSF, and may also be observed in patients receiving chemotherapy.
Department of Dermatology, Hospital Universitario de la Princesa, Madrid, Spain. agarciad@meditex.es
R
R
Valks
E
E
Vargas
E
E
Munõz
J
J
Fernández-Herrera
A
A
Garcia-Diéz
J
J
Fraga
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D005076:Exanthema / Q000209:etiology*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000009:adverse effects; D006801:Humans; D008264:Macrophages / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy*; D012867:Skin / Q000473:pathology*
D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor