Chemoprotective effect of Sobatum against cyclophosphamide toxicity in mice.
The partially purified component of Solanum trilobatum named as Sobatum was found to be cytotoxic in Dalton's lymphoma ascites (DLA), Ehrlich ascites (EA) and tissue cultured cells. It significantly inhibited the peritoneal and solid tumours induced by DLA and EA tomour cells along with the chemically induced skin carcinogenesis. Sobatum did not produce any chromosomal anomalies in the bone marrow cells of Swiss mice. In the present study, we have evaluated the chemoprotective effect of Sobatum on cyclophosphamide induced toxicity in mice. The results showed that the co-administration of Sobatum increase the total leucocyte count, haemoglobin level, average life span of animals; we concluded that Sobatum has chemoprotective action on cyclophosphamide induced toxicity.
Mohanan
P V
PV
Toxicology Group, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India.
Devi
K S
KS
D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D018906:Antineoplastic Agents, Alkylating / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D003520:Cyclophosphamide / Q000633:toxicity*; D004347:Drug Interactions; D006454:Hemoglobins / Q000187:drug effects / Q000378:metabolism; D007958:Leukocyte Count / Q000187:drug effects; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*
D016588:Anticarcinogenic Agents; D018906:Antineoplastic Agents, Alkylating; D006454:Hemoglobins; D010936:Plant Extracts; C110896:Sobatum; D003520:Cyclophosphamide