[Peripheral neuropathy investigation in the early stage of bone marrow transplantation].
Forty-three patients with several hematological diseases in the early stage of bone marrow transplantation were prospectively studied. All patients underwent a complete neurological examination, vibratory sense perception test and nerve conduction study both before and after the bone marrow transplantation. The following nerves were studied: median, peroneal, posterior tibial (motor), median and sural (sensitive). Most patients were in busulphan, cyclophosphamide, cyclosporine A, methotrexate and corticosteroids. Although the results showed statistical differences in the nerve conduction study, all of these differences were not sufficient to induce or diagnose peripheral nerve injury. Therefore, it was concluded that drugs used in the bone marrow transplantation do not induce peripheral neuropathy.
Zétola
V H
VH
Departamento de Clínica Médica do Hospital de Clínicas (HC), Universidade Federal do Paraná (UFPR), Curitiba, Brasil.
Scola
R H
RH
Pasquini
R
R
Werneck
L C
LC
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000009:adverse effects; D000328:Adult; D016026:Bone Marrow Transplantation; D002066:Busulfan / Q000009:adverse effects; D002648:Child; D003430:Cross-Sectional Studies; D003520:Cyclophosphamide / Q000009:adverse effects; D016572:Cyclosporine / Q000009:adverse effects; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D015994:Incidence; D008297:Male; D008727:Methotrexate / Q000009:adverse effects; D008875:Middle Aged; D009431:Neural Conduction; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000453:epidemiology*; D011184:Postoperative Period; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors
D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D003520:Cyclophosphamide; D002066:Busulfan; D008727:Methotrexate