Peribulbar anaesthesia using a mixture of local anaesthetic and vecuronium.
The aim of this double-blind, randomised study was to assess the effects of the addition of 0.5 mg of vecuronium bromide to a standard local anaesthetic mixture used for peribulbar anaesthesia. We studied 60 patients undergoing regional anaesthesia for intra-ocular surgery and were primarily interested in the quality of globe and lid akinesia. All received a mixture of 5 ml 2% lignocaine with 1:200,000 adrenaline, 5 ml 0.75% bupivacaine and 150 IU hyaluronidase with either 0.9% saline 0.25 ml (group A, n = 30) or vecuronium bromide 0.25 ml (0.5 mg) (group B, n = 30). Eye movements assessed at both 5 and 10 min were significantly reduced in the vecuronium group (group B) (p < 0.05). We conclude that the addition of vecuronium at a dose of 0.5 mg to the standard local anaesthetic mixture improves the quality of globe and lid akinesia.
Department of Anaesthesia, General Infirmary at Leeds, UK
G
G
Reah
A R
AR
Bodenham
P
P
Braithwaite
J
J
Esmond
M J
MJ
Menage
D000368:Aged; D000369:Aged, 80 and over; D000765:Anesthesia, Conduction / Q000379:methods*; D019162:Anesthetics, Combined; D000779:Anesthetics, Local; D002045:Bupivacaine; D004311:Double-Blind Method; D005133:Eye Movements / Q000187:drug effects; D005260:Female; D006801:Humans; D008012:Lidocaine; D008297:Male; D003473:Neuromuscular Nondepolarizing Agents; D013508:Ophthalmologic Surgical Procedures; D014673:Vecuronium Bromide
D019162:Anesthetics, Combined; D000779:Anesthetics, Local; D003473:Neuromuscular Nondepolarizing Agents; D014673:Vecuronium Bromide; D008012:Lidocaine; D002045:Bupivacaine