E and P selectins are not required for resistance to severe murine lyme arthritis.
Borrelia burgdorferi-induced arthritis in mice is characterized by tendonitis, synovitis, and inflammatory-cell infiltrate, predominantly of neutrophils. Because genetic deficiency in E and P selectins results in delayed recruitment of neutrophils to sites of inflammation, mice with this deficiency were tested for their response to infection with B. burgdorferi. E and P selectins were not required for the control of B. burgdorferi numbers, nor did deficiency in E and P selectins result in alteration of arthritis severity.
Seiler
K P
KP
Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Ma
Y
Y
Weis
J H
JH
Frenette
P S
PS
Hynes
R O
RO
Wagner
D D
DD
Weis
J J
JJ
D000818:Animals; D000843:Ankle Joint / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D001170:Arthritis, Infectious / Q000276:immunology* / Q000382:microbiology; D015748:Borrelia burgdorferi Group / Q000276:immunology*; D019040:E-Selectin / Q000235:genetics / Q000276:immunology*; D005260:Female; D007113:Immunity, Innate / Q000276:immunology; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D019007:P-Selectin / Q000235:genetics / Q000276:immunology*
D019040:E-Selectin; D019007:P-Selectin