Comparison of topical administration of clotrimazole through surgically placed versus nonsurgically placed catheters for treatment of nasal aspergillosis in dogs: 60 cases (1990-1996).
OBJECTIVE
To examine the clinical response to topical administration of clotrimazole in dogs with nasal aspergillosis, to compare effect of surgically placed versus nonsurgically placed catheters used for administration on outcome, and to examine whether subjective scoring of computed tomographic images can predict outcome.


METHODS
Retrospective case series.


METHODS
60 dogs with nasal aspergillosis.


METHODS
Information including signalment, history, diagnostics, treatment method, and outcome was retrieved from medical records of dogs with nasal aspergillosis treated between 1990 and 1996 at the University of California School of Veterinary Medicine or cooperating referral practices. Final outcome was determined by telephone conversations with owners and referring veterinarians. Images obtained before treatment were subjectively assessed to develop an algorithm for predicting outcome.


RESULTS
Clotrimazole solution (1%) was infused during a 1-hour period via catheters surgically placed in the frontal sinus and nose (27 dogs) and via nonsurgically placed catheters in the nose (18). An additional 15 dogs received 2 to 4 infusions by either route. Topical administration of clotrimazole resulted in resolution of clinical disease in 65% of dogs after 1 treatment and 87% of dogs after one or more treatments. The scoring system correctly classified dogs with unfavorable and favorable responses 71 to 78% and 79 to 93% of the time, respectively.


CONCLUSIONS
Topical administration of clotrimazole, using either technique, was an effective treatment for nasal aspergillosis in dogs. Use of non-invasive intranasal infusion of clotrimazole eliminated the need for surgical trephination of frontal sinuses in many dogs and was associated with fewer complications.
Department of Surgical, School of Veterinary Medicine, University of California, Davis 95616, USA.
K G
KG
Mathews
A P
AP
Davidson
P D
PD
Koblik
E F
EF
Richardson
J
J
Komtebedde
D
D
Pappagianis
R F
RF
Hector
P H
PH
Kass
D000281:Administration, Intranasal; D000287:Administration, Topical; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy / Q000662:veterinary*; D002408:Catheters, Indwelling / Q000662:veterinary; D003022:Clotrimazole / Q000008:administration & dosage / Q000627:therapeutic use*; D003475:Curettage / Q000662:veterinary; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D005500:Follow-Up Studies; D005624:Frontal Bone / Q000601:surgery; D005626:Frontal Sinus / Q000601:surgery; D007263:Infusions, Parenteral / Q000662:veterinary; D008297:Male; D009666:Nose; D012189:Retrospective Studies; D012220:Rhinitis / Q000188:drug therapy / Q000662:veterinary*; D013396:Suction / Q000662:veterinary; D014057:Tomography, X-Ray Computed / Q000662:veterinary; D017211:Treatment Failure; D016896:Treatment Outcome; D014207:Trephining / Q000662:veterinary
D000935:Antifungal Agents; D003022:Clotrimazole