Linkage analysis and construction of a congenic strain for a blood pressure QTL on rat chromosome 9.
A blood pressure quantitative trait locus was found (LOD = 5.0) on rat chromosome 9 using a large F2 population (N = 233) derived from Dahl salt-sensitive (S) and Dahl salt-resistant (R) rats. The F2 rats were fed 8% NaCl diet for 8 weeks. A congenic strain introgressing the R low-blood-pressure QTL allele on chromosome 9 into the S strain was constructed. The congenic strain, designated S.R(chr 9), had a lower blood pressure (19 mm Hg, P < 0.0001) and lower heart weight (112 mg, P < 0.0001) than S rats (2% NaCl diet for 24 days), proving the existence of a blood pressure QTL in the congenic region of about 21 cM.
Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43614-5804, USA.
J P
JP
Rapp
M R
MR
Garrett
H
H
Dene
H
H
Meng
B
B
Hoebee
G M
GM
Lathrop
D000818:Animals; D020296:Animals, Congenic; D001794:Blood Pressure / Q000235:genetics*; D002874:Chromosome Mapping; D004032:Diet; D005838:Genotype; D006321:Heart; D007178:Inbreeding; D007265:Inhibins / Q000235:genetics; D009929:Organ Size; D010455:Peptides / Q000235:genetics; D019655:Quantitative Trait, Heritable; D051381:Rats; D020303:Rats, Inbred Dahl; D017673:Sodium Chloride, Dietary
D010455:Peptides; D017673:Sodium Chloride, Dietary; C094377:inhibin-alpha subunit; D007265:Inhibins