Transplantation of autologous sympathetic ganglion into the brain with Parkinson's disease. Long-term follow-up of 35 cases.
Transplantation of autologous sympathetic ganglion was performed in 35 patients with Parkinson's disease. Approximately half the patients showed improvement of parkinsonian symptoms over the 3 years following transplantation. The patients showed amelioration of bradykinesia and gait disturbance, but tremor and muscle rigidity were not improved by transplantation. The other half of the patients did not show amelioration after transplantation. No serious complications were encountered, though mild ptosis was observed in all patients. The mechanism of improvement of symptoms might be the release of dopamine from the grafted sympathetic ganglion. Transplantation of autologous sympathetic ganglion can be a therapeutic modality for Parkinson's disease.
Department of Neurological Surgery, Wakayama Medical College, Japan.
T
T
Itakura
Y
Y
Uematsu
N
N
Nakao
E
E
Nakai
K
K
Nakai
D000328:Adult; D000368:Aged; D002421:Caudate Nucleus / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis / Q000601:surgery*; D011699:Putamen / Q000601:surgery*; D013233:Stellate Ganglion / Q000637:transplantation*; D013238:Stereotaxic Techniques; D014182:Transplantation, Autologous; D016896:Treatment Outcome