2-Pyrazolin-5-ones structurally related to certain analgesics and antipyretic drugs and their anti-inflammatory activity.
The anti-inflammatory activity of twenty six 2-pyraxolin-5-one derivatives (Ia-z) was studied using carrageenin induced paw edema in male albino rats. Compounds 1(1)-Ip exhibited moderate anti-inflammatory activity, while the rest were devoid of significant anti-inflammatory activity.
Department of Chemistry, Faculty of Science, Makerere University, Kampala, Uganda.
G B
GB
Mpango
M A
MA
Metwally
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D008297:Male; D011720:Pyrazoles / Q000138:chemical synthesis*; D051381:Rats; D013329:Structure-Activity Relationship
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011720:Pyrazoles; D002351:Carrageenan