Superovulation with a high gonadotropin dose for in vitro fertilization: is it effective?
OBJECTIVE
Our purpose was to investigate the effect on the ovarian response of increasing the gonadotropin dose.


METHODS
We analyzed retrospectively the in vitro fertilization data for patients who had two cycles of treatment, with a higher dose in cycle 2. The patients were stratified according to age, ovarian response, and gonadotropin dose in the first cycle. The main outcome measure was the number of follicles, eggs, and embryos and the peak estradiol (E2) level.


RESULTS
The study included 244 patients. Patients in both age groups (n = 118, < or = 33 years; n = 126, > 33 years), low (n = 66) and intermediate (n = 145) responders, and patients who received < 225 IU follicle-stimulating hormone (n = 175) in cycle 1 had a better response in cycle 2. However, the high responders (n = 33) and those who received 225 or 300 IU follicle-stimulating hormone (n = 69) in cycle 1 showed a similar response in both cycles, except for a significantly higher E2 level in cycle 2.


CONCLUSIONS
Our results indicate that exceeding a daily dose of 300 IU is unrewarding.
Academic Department, Birmingham University, Birmingham Women's Hospital, Edgbaston, U.K.
H
H
Lashen
W
W
Ledger
A
A
López Bernal
B
B
Evans
D
D
Barlow
D000328:Adult; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro / Q000187:drug effects / Q000379:methods*; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage / Q000494:pharmacology; D006062:Gonadotropins / Q000008:administration & dosage* / Q000494:pharmacology; D006801:Humans; D006080:Ovarian Follicle / Q000187:drug effects / Q000378:metabolism; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D013480:Superovulation
D006062:Gonadotropins; D004958:Estradiol; D005640:Follicle Stimulating Hormone