Inhibition by tranilast of vascular endothelial growth factor (VEGF)/vascular permeability factor (VPF)-induced increase in vascular permeability in rats.
We studied the effects of tranilast, an anti-allergic and anti-proliferative drug in clinical use, on VEGF/VPF-induced vascular permeability in a rat air pouch model. A large increase in vascular permeability was induced by injection of 4 ml of a 100 ng/ml VEGF/VPF solution into the preformed air pouch. Over a 15-min period, tranilast inhibited the VEGF/VPF-induced vascular permeability in a dose-dependent manner. This result suggests that tranilast, which we recently found to inhibit VEGF/VPF-induced angiogenesis, could also improve VEGF/VPF-dependent increases in vascular permeability.
Discovery Research Laboratories, Kissei Pharmaceutical Co., Ltd., Minamiazumi, Nagano-Pref., Japan.
M
M
Isaji
H
H
Miyata
Y
Y
Ajisawa
N
N
Yoshimura
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D016228:Endothelial Growth Factors / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D008222:Lymphokines / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D062367:ortho-Aminobenzoates / Q000494:pharmacology*
D016228:Endothelial Growth Factors; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D062367:ortho-Aminobenzoates; C012293:tranilast