Streptozotocin-induced diabetic cynomolgus monkey is a model of hypertriglyceridemia with low high-density lipoprotein cholesterol.
Hypertriglyceridemia with low high-density lipoprotein (HDL) cholesterol is a risk factor of cardiovascular disease. We attempted to create an animal model of hypertriglyceridemia with low HDL cholesterol by intravenously injecting 30 mg/kg body weight streptozotocin (STZ) to cynomolgus monkeys. This induced hypoinsulinemia and resulted in a decrease in postheparin plasma lipoprotein lipase (LPL) activity and LPL enzyme mass, reduction of plasma HDL cholesterol and elevation of triglycerides. Low HDL cholesterol subsequently caused a reduction of HDL2b cholesterol, while hypertriglyceridemia caused an elevation of very low-density lipoprotein (VLDL) triglyceridemia. Apolipoprotein CII, a co-factor of LPL, was not affected by STZ administration. These results show that hypertriglyceridemia with low HDL cholesterol results from a reduction of LPL activity without affecting apolipoprotein CII after STZ administration. The STZ-induced diabetic cynomolgus monkey is a model of hypertriglyceridemia with low HDL cholesterol, and may be potentially beneficial for studying atherosclerosis caused by hypertriglyceridemia with low HDL cholesterol.
Tsutsumi
K
K
Nutrition Research Institute, Otsuka Pharmaceutical Factory Inc., Naruto, Tokushima, Japan.
Iwamoto
T
T
Hagi
A
A
Kohri
H
H
D000818:Animals; D053304:Apolipoprotein C-II; D001056:Apolipoproteins C / Q000378:metabolism; D001786:Blood Glucose; D008076:Cholesterol, HDL / Q000097:blood*; D003921:Diabetes Mellitus, Experimental / Q000150:complications*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006493:Heparin / Q000378:metabolism; D015228:Hypertriglyceridemia / Q000097:blood* / Q000209:etiology; D008055:Lipids / Q000097:blood; D008071:Lipoprotein Lipase / Q000378:metabolism; D008074:Lipoproteins / Q000097:blood; D008252:Macaca fascicularis; D008297:Male; D013311:Streptozocin
D053304:Apolipoprotein C-II; D001056:Apolipoproteins C; D001786:Blood Glucose; D008076:Cholesterol, HDL; D008055:Lipids; D008074:Lipoproteins; D013311:Streptozocin; D006493:Heparin; D008071:Lipoprotein Lipase