Antiplatelet and antithrombotic effects of a combination of ticlopidine and ginkgo biloba ext (EGb 761).
The antiplatelet and antithrombotic effects of the oral combination treatment of ticlopidine and Ginkgo biloba extract (EGb 761) were studied in normal and thrombosis-induced rats. The ex vivo inhibitory effect on ADP-induced platelet aggregation of a small dose of ticlopidine (50 mg/kg/day) in combination with EGb 761 (40 mg/kg/day) was comparable to a larger dose of only ticlopidine (200 mg/kg/day). Bleeding time was also prolonged by 150%. Thrombus weight was also consistently decreased by a combination of ticlopidine and EGb 761 in an arterio-venous shunt model at two doses of ticlopidine (50 mg/kg) plus EGb 761 (20 mg/kg) and ticlopidine (50 mg/kg) plus EGb 761 (40 mg/kg). A combinatory treatment in acute thrombosis model in mice also showed a higher recovery than a single treatment.
Kim
Y S
YS
Natural Products Research Institute, Seoul National University, Korea.
Pyo
M K
MK
Park
K M
KM
Park
P H
PH
Hahn
B S
BS
Wu
S J
SJ
Yun-Choi
H S
HS
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects*; D003094:Collagen / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004837:Epinephrine / Q000494:pharmacology; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D005419:Flavonoids / Q000008:administration & dosage / Q000494:pharmacology*; D020441:Ginkgo biloba; D006490:Hemostatics / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D010936:Plant Extracts; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D013927:Thrombosis / Q000139:chemically induced; D013988:Ticlopidine / Q000008:administration & dosage / Q000494:pharmacology*; D000096983:Ginkgo Extract
D003094:Collagen; D004837:Epinephrine; D005343:Fibrinolytic Agents; D005419:Flavonoids; D006490:Hemostatics; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; D013988:Ticlopidine; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract