Protective effects of cystone, a polyherbal ayurvedic preparation, on cisplatin-induced renal toxicity in rats.
Cystone, a polyherbal ayurvedic preparation, was found to protect rats partially but significantly against cisplatin-induced renal toxicity, when given intraperitonially 1 h before cisplatin. At 500 and 1000 microg/ml, it also inhibited lipid peroxidation induced by cisplatin in renal cortical slices by 62.7 and 71.6%, respectively. The rats pretreated with cystone (1000 mg/kg i.p.) had significantly lower blood urea nitrogen (BUN) and serum creatinine (33.8 and 0.92 mg/dl, respectively) compared to cisplatin alone (51.5 and 1.41 mg/dl, respectively). The control animals had 17.1 and 0.63 mg/dl, respectively. The cystone treated animals lost 5.63 g body weight compared to 12.5 g for cisplatin alone treated animals on day 5. Renal functions like urine to serum creatinine ratio and creatinine clearance showed significant improvement when cystone was given 1 h before cisplatin. However, cystone did not protect increased excretion of urinary protein and decreased WBC count caused by cisplatin. The present study suggests that the cystone protects kidney against cisplatin-induced toxicity and the protection may be mediated through its ability to inhibit lipid peroxidation.
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Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Manipal, India. info@mahe.ernet.in
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D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001806:Blood Urea Nitrogen; D001835:Body Weight / Q000187:drug effects; D002945:Cisplatin / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D004336:Drug Antagonism; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D007677:Kidney Function Tests; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008515:Medicine, Ayurvedic; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
D000970:Antineoplastic Agents; D010936:Plant Extracts; C041060:cystone; D003404:Creatinine; D002945:Cisplatin