[Classification of cytokine receptor superfamily and signal transduction--structural feature and functional property].
Cytokines are groups of protein mediators that are involved in cell to cell communication and are classified into several distinct families based on their receptor structures. The class I cytokine receptor family includes most of interleukins and colony stimulating factors receptors and shares a conserved extracellular motif with homology to the fibronectin type III domain. While they do not have any intrinsic enzymatic activity, they bind a member of JAK family kinases. The receptors form a homo- or hetero-multimer by cytokine binding and activate the JAKs associated with the receptor. There are some groups of cytokines which exhibit similar functions by sharing the same receptor subunit.
Tanaka
M
M
Laboratory of Cellular Biosynthesis, University of Tokyo.
Miyajima
A
A
D000818:Animals; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D018121:Receptors, Cytokine / Q000737:chemistry / Q000145:classification* / Q000502:physiology; D015398:Signal Transduction
D018121:Receptors, Cytokine; D011505:Protein-Tyrosine Kinases