The contribution of lipids and lipid metabolism to cellular functions of the Golgi complex.
The history of the Golgi complex now reaches its 100 year anniversary. Over the past several decades, tremendous effort has gone into cataloguing Golgi resident proteins, measuring the lipid compositions of Golgi membranes, and in elucidating the pathways by which proteins and lipids traffic through this unique organelle. Only in the past 8 years or so has experimental scrutiny extended to the investigation of how lipids and proteins cooperate to endow the Golgi with its various capabilities regarding protein/lipid transport and sorting. In this chapter we review some of the most recent advances in deciphering the functional interfaces between lipids and proteins of the Golgi complex.
Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294-0005, USA.
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M
Fang
M P
MP
Rivas
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Bankaitis
D000818:Animals; D001692:Biological Transport; D006056:Golgi Apparatus / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism; D050356:Lipid Metabolism; D008055:Lipids / Q000502:physiology*; D010716:Phosphatidylinositols / Q000378:metabolism; D010743:Phospholipids / Q000096:biosynthesis
D008055:Lipids; D010716:Phosphatidylinositols; D010743:Phospholipids