Changes in CNTF receptor alpha expression in rat skeletal muscle during the recovery period after hindlimb suspension.
This study investigated whether modifications in the contractile function of rat muscle after 3 weeks of hindlimb suspension followed by different recovery periods were associated with changes in ciliary neurotrophic factor (CNTF) receptor alpha. CNTF receptor alpha was stronger in control extensor digitorum longus (EDL) than soleus. CNTF receptor alpha was increased in unweighted as compared to control soleus muscle, while no significant changes occurred in EDL muscle. Furthermore, CNTF level was not significantly modified in adult sciatic nerve.
Laboratoire de Biologie cellulaire, Neuroimmunologie Neuropathologie, Centre Hospitalier Universitaire, Angers, France.
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Guillet
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Huchet-Cadiou
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Gascan
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Léoty
D000818:Animals; D015152:Blotting, Northern; D004797:Enzyme-Linked Immunosorbent Assay; D019417:Hindlimb Suspension / Q000502:physiology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009929:Organ Size / Q000502:physiology; D051381:Rats; D020794:Receptor Protein-Tyrosine Kinases / Q000096:biosynthesis*; D020801:Receptor, Ciliary Neurotrophic Factor; D017475:Receptors, Nerve Growth Factor / Q000096:biosynthesis*; D012584:Sciatic Nerve / Q000378:metabolism / Q000502:physiology
D009419:Nerve Tissue Proteins; D020801:Receptor, Ciliary Neurotrophic Factor; D017475:Receptors, Nerve Growth Factor; D020794:Receptor Protein-Tyrosine Kinases