Radiopaque poly(2-hydroxyethyl methacrylate) particles containing silver iodide complexes tested on cell culture.
Silver iodide complexes have been used as an effective radiopacifying agent to prepare radiopaque poly(2-hydroxyethyl methacrylate) (poly(HEMA)) particles. Incorporation of silver iodide complexes inside the poly(HEMA) particles was achieved by first swelling particles in potassium iodide solution and precipitating the silver iodide complexes using a 30 wt% solution of silver nitrate. The dry particles contained 15 wt% of silver iodide complexes. Particles were easily monitored using a standard imaging technique based on X-ray absorption. Toxicity of the particles has been determined in in vitro experiments on a cell culture. As no inhibition of growth of cells surrounding the particles was observed, they can be considered non-toxic.
Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Prague.
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D001672:Biocompatible Materials; D002294:Carcinoma, Squamous Cell; D002455:Cell Division / Q000187:drug effects; D003287:Contrast Media / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D007454:Iodides / Q000737:chemistry / Q000494:pharmacology*; D010316:Particle Size; D011102:Polyhydroxyethyl Methacrylate / Q000737:chemistry / Q000494:pharmacology*; D018030:Silver Compounds / Q000737:chemistry / Q000494:pharmacology*; D012835:Silver Nitrate / Q000737:chemistry; D014407:Tumor Cells, Cultured
D001672:Biocompatible Materials; D003287:Contrast Media; D007454:Iodides; D018030:Silver Compounds; D011102:Polyhydroxyethyl Methacrylate; C030584:silver iodide; D012835:Silver Nitrate