The caspase-RB connection in cell death.
Execution of the cell-death programme requires the activation of a family of cysteine proteases known as caspases. Specific cellular proteins are cleaved by caspases during apoptosis, including the retinoblastoma tumour-suppressor protein (RB1). A caspase-resistant RB1 can attenuate the death response to tumour necrosis factor alpha. The cleavage of RB1 during cell death, together with the increased cell death during embryonic development of Rb-knockout mice, suggests that RB1 degradation contributes to the activation of the cell-death pathway.
Dept of Biology, University of California, San Diego, La Jolla 92093-0322, USA.
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D000818:Animals; D016923:Cell Death / Q000502:physiology*; D003546:Cysteine Endopeptidases / Q000378:metabolism* / Q000502:physiology; D003598:Cytoskeletal Proteins / Q000378:metabolism / Q000502:physiology; D006801:Humans; D016160:Retinoblastoma Protein / Q000378:metabolism* / Q000502:physiology
D003598:Cytoskeletal Proteins; D016160:Retinoblastoma Protein; D003546:Cysteine Endopeptidases