Standardized assessment of disease status in patients with primary Sjögren's syndrome: the foundation for creating criteria for disease activity and damage?
Primary Sjögren's syndrome (pSS) is increasingly acknowledged as a disease entity with consistent pathogenesis and clinical presentation. This has encouraged proposals for uniform nomenclature, as well as for classification of disease subsets and clinical disease manifestations. The purpose of this literature survey is to analyse present pathogenetic and clinical data on pSS from the viewpoint of their usability for developing criteria for activity and damage. It appears that the routinely used tests for evaluating clinical disease manifestations in pSS probably measure both activity and damage. Moreover, no immunopathogenic marker has been shown to adequately represent all aspects of disease activity in pSS. The survey demonstrates the need for longitudinal studies in which potential markers of disease activity and damage are validated.
Oxholm
P
P
Department of Rheumatology U, Copenhagen County Hospital in Gentofte, Hellerup, Denmark. droxholm@inet.uni-c.dk
Asmussen
K
K
D015415:Biomarkers; D006801:Humans; D012859:Sjogren's Syndrome / Q000145:classification / Q000503:physiopathology*; D009626:Terminology as Topic
D015415:Biomarkers