Therapeutic vaccination against chronic viral infection: the importance of cooperation between CD4+ and CD8+ T cells.
The goal of therapeutic vaccination is to elicit an antiviral immune response within persistently infected individuals and consequently eradicate the infection. CD8+ T cells are potent mediators of viral clearance; however, during chronic infections CD4+ T cell help is required to sustain antiviral CD8+ T cell activity. Therapeutic vaccination should be targeted towards enhancing both CD4+ and CD8+ T cell virus-specific responses.
Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA.
A J
AJ
Zajac
K
K
Murali-Krishna
J N
JN
Blattman
R
R
Ahmed
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002908:Chronic Disease; D006801:Humans; D008213:Lymphocyte Activation; D014611:Vaccination; D014765:Viral Vaccines / Q000627:therapeutic use*; D014777:Virus Diseases / Q000188:drug therapy / Q000276:immunology*
D014765:Viral Vaccines