Hoarding and treatment response in 38 nondepressed subjects with obsessive-compulsive disorder.
OBJECTIVE
The authors studied factors associated with short-term treatment response in 38 nondepressed subjects with DSM-III-R obsessive-compulsive disorder (OCD).


METHODS
The subjects completed 12 weeks of treatment with paroxetine (N = 20), placebo (N = 8), or cognitive-behavioral therapy (N = 10). Clinician and self-rated measures were gathered at baseline, during treatment, and after treatment.


RESULTS
Seventeen (45%) subjects had "much" or "very much" improvement and achieved at least a 40% decrease in their total Yale-Brown Obsessive Compulsive Scale (Y-BOCS) score. Responders had lower obsessive-compulsive scores on the Symptom Checklist 90-Revised, had a lower checking score on the Maudsley Obsessive-Compulsive Inventory, were less likely to have had prior drug therapy, and in general suffered more obsessive-compulsive symptoms. They were significantly less likely to have hoarding obsessions and corresponding compulsions. The latter finding was confirmed using multiple regression analysis.


CONCLUSIONS
Hoarding is an important symptom that predicts poor treatment response in patients with OCD.
Department of Psychiatry, University of Iowa College of Medicine, Iowa City 52242-1000, USA.
D W
DW
Black
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Monahan
J
J
Gable
N
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Blum
G
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Clancy
P
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Baker
D000367:Age Factors; D017668:Age of Onset; D001008:Anxiety Disorders / Q000453:epidemiology; D015928:Cognitive Behavioral Therapy; D015897:Comorbidity; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D017374:Paroxetine / Q000627:therapeutic use*; D010555:Personality Inventory / Q000706:statistics & numerical data; D010919:Placebos; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D016896:Treatment Outcome
D010919:Placebos; D017374:Paroxetine