The Achilles' heel of trypanosomatids: trypanothione-mediated hydroperoxide metabolism.
Flohé
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Lehrstuhl für Physiologische Chemie, Technischen Universität Braunschweig, Germany.
D000818:Animals; D016831:Crithidia fasciculata / Q000378:metabolism; D015195:Drug Design; D005978:Glutathione / Q000031:analogs & derivatives* / Q000378:metabolism; D006801:Humans; D008658:Inactivation, Metabolic; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D010544:Peroxidases / Q000378:metabolism*; D013095:Spermidine / Q000031:analogs & derivatives* / Q000378:metabolism; D014344:Trypanocidal Agents / Q000737:chemistry* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D014345:Trypanosoma / Q000378:metabolism; D014351:Trypanosomatina / Q000378:metabolism*
D014344:Trypanocidal Agents; D009249:NADP; C044809:trypanothione; D010544:Peroxidases; D009247:NADH, NADPH Oxidoreductases; C049608:trypanothione reductase; D005978:Glutathione; D013095:Spermidine