Peripheral blood stem cell mobilization with granulocyte colony-stimulating factor and a harvesting procedure in pediatric donors.
The safety of injecting healthy donors with granulocyte colony-stimulating factor (G-CSF) has not been established. To evaluate PBSC mobilization and harvesting efficacy in the pediatric population, we compared it with those in adult donors. In this study, we conclude that PBSC mobilization and harvesting protocol in normal pediatric donors can be performed safely and effectively. Considering the lower frequency of side-effects and WBC counts, and G-CSF kinetics, higher dose of G-CSF would be recommended when small children become donors for adult patients.
Kawano
Y
Y
Department of Pediatrics, The University of Tokushima, Japan.
Takaue
Y
Y
Watanabe
T
T
Watanabe
A
A
Iwai
A
A
Kuroda
Y
Y
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001782:Blood Donors; D002648:Child; D002675:Child, Preschool; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology*; D019650:Hematopoietic Stem Cell Mobilization; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D014184:Transplantation, Homologous
D016179:Granulocyte Colony-Stimulating Factor