Gastroprotective effect of Copaifera langsdorffii oleo-resin on experimental gastric ulcer models in rats.
The effects of oleo-resin obtained from the stem bark of Copaifera langsdorffii on ethanol, indomethacin and hypothermic restraint-stress induced gastric lesions were studied in rats. Oral administration of oleo-resin at doses of 200 and 400 mg/kg provided dose-dependent significant protection against gastric damage caused by ethanol and restraint stress, and at a dose of 400 mg/kg it also prevented the gastric ulceration induced by indomethacin. Further, in the 4 h pylorus ligated rats, the accumulation of gastric juice volume and the mucus secretion was significantly enhanced by oleo-resin whereas the total acidity was inhibited. These results highlight the gastroprotective potential of C. langsdorffii oleo-resin and the need for a systematic study on this traditional remedy.
Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará (CCS), Fortaleza, CE, Brazil.
L A
LA
Paiva
V S
VS
Rao
N V
NV
Gramosa
E R
ER
Silveira
D000818:Animals; D001453:Balsams / Q000008:administration & dosage / Q000494:pharmacology*; D004195:Disease Models, Animal; D000431:Ethanol / Q000009:adverse effects; D007887:Fabaceae / Q000737:chemistry*; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D007213:Indomethacin / Q000009:adverse effects; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000209:etiology; D013312:Stress, Physiological / Q000150:complications
D001453:Balsams; D010936:Plant Extracts; C114971:copaiba balsam; D000431:Ethanol; D007213:Indomethacin