Novel HLA-A and HLA-B alleles.
Nine novel HLA-A and HLA-B alleles are described: A*2609, A*6803, A*6806, B*1539, B*1540, B*2712, B*4103, B*5109, and B*5603. Most appear to have arisen by gene conversion events. B*5603 appears to have arisen by a reciprocal recombination event joining exon 2 of a B*55/ *56 allele with exon 3 of a B*15 allele. Serologically, the antigen encoded by this allele types with broad B22- and Bw6-specific alloantisera. Also unique, the antigen encoded by B*2712 does not react with B27-specific alloantisera but does react with Bw6-specific alloantisera.
Hurley
C K
CK
Department of Microbiology and Immunology, Georgetown University Medical School, Washington, DC, USA.
Steiner
N
N
Kosman
C
C
Mitton
W
W
Koester
R
R
Bei
M
M
Bush
J
J
McCormack
J
J
Hahn
A
A
Henson
V
V
Hoyer
R
R
Wade
J A
JA
Hartzman
R J
RJ
Ng
J
J
D000483:Alleles; D000595:Amino Acid Sequence; D001483:Base Sequence; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data
D015234:HLA-A Antigens; D015235:HLA-B Antigens