[Comparative study of 2 antibiotic prophylactic protocols in oncologic surgery of the pharynx and larynx].
The use of antibiotic prophylaxis in oncological pharyngeal and laryngeal surgery has reduced the risk of postoperative wound infection, which decreases morbidity and health-care costs. We report the results of a prospective randomized study in our hospital comparing the effectiveness of two antibiotic protocols, amoxicillin-clavulanate and clindamycin plus gentamicin, both given for 24 hours, in patients who underwent clean-contaminated oncological surgery of the pharynx or larynx.
Ibarrondo
J
J
Servicio de ORL, Hospital General Universitario Vall d'Hebron, Barcelona.
García
M
M
Lorente
J
J
Serra
I
I
Asarta
I
I
Vila
J
J
Pollán
C
C
Quesada
P
P
D000658:Amoxicillin / Q000008:administration & dosage / Q000627:therapeutic use*; D019818:Clavulanic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D002981:Clindamycin / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000601:surgery*; D007825:Laryngectomy / Q000379:methods*; D008297:Male; D037981:Neck Dissection; D010610:Pharyngeal Neoplasms / Q000601:surgery*; D010611:Pharyngectomy / Q000379:methods*; D011229:Preanesthetic Medication; D011446:Prospective Studies; D012307:Risk Factors; D013530:Surgical Wound Infection / Q000517:prevention & control*; D016896:Treatment Outcome
D005839:Gentamicins; D019818:Clavulanic Acid; D002981:Clindamycin; D000658:Amoxicillin