Antepartum management protocol. Timing and mode of delivery in gestational diabetes.
We sought to determine whether strict glycemic control during diabetic pregnancy combined with elective early induction of labor reduces the rate of cesarean delivery and fetal birth trauma. We used a population-based longitudinal design covering three periods corresponding to changes in the management protocol for diabetic pregnancy at our center: 1) 1980-1989: no set level of maternal glycemia, elective cesarean section when estimated fetal weight was 4,500 g or more, and no elective early induction; 2) 1990-1992: desired mean maternal glycemia < or = 5.8 mmol/l, elective cesarean section when estimated fetal weight was 4,000 g or more, and elective early induction at 40 weeks for large-for-gestational-age fetuses; 3) 1993-1995: desired mean maternal glycemia < or = 5.3 mmol/l, elective cesarean section when estimated fetal weight was 4,000 g or more, and elective early induction at 38 weeks for large-for-gestational-age fetuses. Outcome of diabetic pregnancies was compared for the three periods, relative to that of the normal population. There was a gradual, constant, and significant decline in the incidence of macrosomia (17.9, 14.9, and 8.8%, respectively; P < 0.05) and large-for-gestational-age fetuses (23.6, 21.0, and 11.7%; P < 0.05) coupled with a gradual, nonsignificant decrease in cesarean deliveries (20.6, 18.4, and 16.2%) and in cases of shoulder dystocia (1.5, 1.2, and 0.6%), to rates close to those of the normal population. Our data show that maintaining strict control of maternal diabetes and adhering to an active management protocol for early elective delivery based on the estimated fetal weight have a significant effect on reducing the rate of macrosomia, thereby affecting the incidence of both traumatic births and cesarean deliveries.
Hod
M
M
Department of Obstetrics and Gynecology, Rabin Medical Center, Tel Aviv, Israel. hodroyal@netvision.net.il
Bar
J
J
Peled
Y
Y
Fried
S
S
Katz
I
I
Itzhak
M
M
Ashkenazi
S
S
Schindel
B
B
Ben-Rafael
Z
Z
D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D002585:Cesarean Section / Q000706:statistics & numerical data; D002985:Clinical Protocols; D036861:Delivery, Obstetric / Q000706:statistics & numerical data*; D016640:Diabetes, Gestational / Q000097:blood / Q000188:drug therapy; D005260:Female; D005320:Fetal Macrosomia / Q000453:epidemiology; D005333:Fetus / Q000033:anatomy & histology / Q000502:physiology; D005865:Gestational Age; D006784:Hospitals, Teaching; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D015994:Incidence; D007231:Infant, Newborn; D007328:Insulin / Q000627:therapeutic use; D007557:Israel; D007751:Labor, Induced / Q000706:statistics & numerical data; D008137:Longitudinal Studies; D011247:Pregnancy; D011256:Pregnancy Outcome; D011295:Prenatal Care; D012016:Reference Values; D012107:Research Design
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin