Ovarian testosterone secretion during perimenopause.
OBJECTIVE
The aim of the study was to investigate ovarian testosterone secretion during the last few years of reproductive life and after menopause.


METHODS
Ovarian and peripheral venous levels of total testosterone were analyzed in 52 women aged 42-69 years (mean 51) undergoing hysterectomy with adnexal removal for benign indications at the Department of Obstetrics and Gynecology at Tampere University Hospital, Finland. The study population was divided into pre- (n = 19), peri- (n = 18) and postmenopausal (n = 15) women in addition to the classical division according to menstrual cycle. Corresponding serum estradiol, progesterone and gonadotropin levels were measured, and the degree of ovarian stromal hyperplasia was analyzed.


RESULTS
The levels of all steroid hormones were higher in the ovarian vein than in the periphery. A significant positive correlation was found between age and ovarian vein testosterone levels (r = 0.3, P = 0.01). In premenopausal women, it was 1.5 nmol/l (median; range 0.78-6.0), in perimenopausal women 2.2 nmol/l (range 0.9-13.6), and 2.5 nmol/l (range 0.6-26.6) in postmenopause, respectively. Peripheral testosterone level did not increase with age. Ovarian stromal hyperplasia was significantly associated with increased testosterone secretion (P = 0.009).


CONCLUSIONS
The ovary seems to increase the secretion of testosterone into circulation during the menopausal transition period, as the highest levels were measured in postmenopausal women. High testosterone levels in the ovarian vein, however, were not reflected in the peripheral venous blood.
Ala-Fossi
S L
SL
Department of Obstetrics, Tampere University Hospital, Finland. sa12869@uta.fi
Mäenpää
J
J
Aine
R
R
Punnonen
R
R
D000328:Adult; D000368:Aged; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood; D006801:Humans; D008593:Menopause / Q000097:blood*; D008597:Menstrual Cycle / Q000097:blood; D008875:Middle Aged; D010053:Ovary / Q000378:metabolism*; D012016:Reference Values; D012636:Secretory Rate / Q000502:physiology; D013739:Testosterone / Q000378:metabolism*
D012739:Gonadal Steroid Hormones; D013739:Testosterone