Antimicrobial and anticonvulsant activities of Viscum capense.
Dichloromethane, methanol and water extracts of Viscum sapense L.f., of the Loranthaceae family, were tested for antimicrobial activities against Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans. Methanol extract was also tested for activity against seizures in albino mice induced by pentylenetetrazole (PTZ), bicuculline and N-methyl-DL-aspartic acid (NMDLA). Methanol extract of V. capense inhibited the growth of S. aureus. Methanol extract also protected the mice against PTZ- and bicuculline-induced tonic seizures but did not significantly alter NMDLA-induced tonic seizures. The data indicate that the extract of V. capense has antibacterial activity against S. aureus and also anticonvulsant activity.
Amabeoku
G J
GJ
Department of Pharmacology, School of Pharmacy, University of the Western Cape, Bellville, South Africa.
Leng
M J
MJ
Syce
J A
JA
D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000927:Anticonvulsants / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D005260:Female; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D014784:Mistletoe / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000927:Anticonvulsants; D010936:Plant Extracts