Methamphetamine-induced dopamine and serotonin reductions in neostriatum are not gender specific in rats with comparable hyperthermic responses.
Methamphetamine (MA)-induced monoamine depletions in male and female Sprague-Dawley CD rats were studied under conditions in which the magnitude of MA-induced hyperthermia was comparable between the sexes. MA (5 or 10 mg/kg) or saline (3 ml/kg) was administered SC four times at 2-h intervals. Animals were sacrificed 3 days posttreatment for the determination of dopamine (DA), serotonin (5-HT), and metabolites. MA induced significant monoamine reductions but the magnitude of these reductions was not significantly different between males and females. In the MA 5 mg/kg groups, neostriatal DA content was reduced by 51.2% and 44.8%, whereas 5-HT content was reduced by 30.6% and 23.9% of controls for males and females, respectively. In the MA 10 mg/kg groups, neostriatal DA content was reduced by 72.9% and 65.8%, whereas striatal 5-HT content was reduced by 77.4% and 73.6% of controls for males and females, respectively. No significant differences in thermal responses to MA were observed between genders. Unlike reports in mice, gender does not play a role in MA-induced monoamine reductions in rat neostriatum when MA-induced hyperthermia is comparable across sexes. The data also showed a threshold effect in which dopamine depletions were not correlated with hyperthermia at core body temperatures above approximately 41 degrees C.
Children's Hospital Research Foundation and Department of Pediatrics, University of Cincinnati, OH 45229-3039, USA.
M
M
Fukumura
G D
GD
Cappon
H W
HW
Broening
C V
CV
Vorhees
D000704:Analysis of Variance; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D016014:Linear Models; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D051379:Mice; D017072:Neostriatum / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000378:metabolism*; D012727:Sex Characteristics; D013045:Species Specificity
D012701:Serotonin; D008694:Methamphetamine; D004298:Dopamine