Methamphetamine-induced dopamine and serotonin reductions in neostriatum are not gender specific in rats with comparable hyperthermic responses.
Methamphetamine (MA)-induced monoamine depletions in male and female Sprague-Dawley CD rats were studied under conditions in which the magnitude of MA-induced hyperthermia was comparable between the sexes. MA (5 or 10 mg/kg) or saline (3 ml/kg) was administered SC four times at 2-h intervals. Animals were sacrificed 3 days posttreatment for the determination of dopamine (DA), serotonin (5-HT), and metabolites. MA induced significant monoamine reductions but the magnitude of these reductions was not significantly different between males and females. In the MA 5 mg/kg groups, neostriatal DA content was reduced by 51.2% and 44.8%, whereas 5-HT content was reduced by 30.6% and 23.9% of controls for males and females, respectively. In the MA 10 mg/kg groups, neostriatal DA content was reduced by 72.9% and 65.8%, whereas striatal 5-HT content was reduced by 77.4% and 73.6% of controls for males and females, respectively. No significant differences in thermal responses to MA were observed between genders. Unlike reports in mice, gender does not play a role in MA-induced monoamine reductions in rat neostriatum when MA-induced hyperthermia is comparable across sexes. The data also showed a threshold effect in which dopamine depletions were not correlated with hyperthermia at core body temperatures above approximately 41 degrees C.
Fukumura
M
M
Children's Hospital Research Foundation and Department of Pediatrics, University of Cincinnati, OH 45229-3039, USA.
Cappon
G D
GD
Broening
H W
HW
Vorhees
C V
CV
D000704:Analysis of Variance; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D016014:Linear Models; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D051379:Mice; D017072:Neostriatum / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000378:metabolism*; D012727:Sex Characteristics; D013045:Species Specificity
D012701:Serotonin; D008694:Methamphetamine; D004298:Dopamine