DPB1*7601, a novel DPB1 variant in the Caucasoid population.
A new DPB1 allele has been identified in a Caucasoid individual, DPB1*7601. The sequence of the complete second exon has been confirmed by cloning and subsequent sequencing. This allele differs by one amino acid, at codon 36, from DPB1*1401, as indicated by SBT and PCR-SSP analysis. The amino-acid motif introduced by the change is shared by DPB1*0401 and some rare alleles. It remains unclear whether the change is due to interallelic microgen conversion or a single point mutation.
Department of Pathology, University Hospital Utrecht, The Netherlands.
E H
EH
Rozemuller
W A
WA
Allebes
E P
EP
van den Berg-Loonen
M
M
Hidajat
A W
AW
van der Zwan
M G
MG
Tilanus
I
I
Joosten
D000595:Amino Acid Sequence; D001483:Base Sequence; D018076:DNA, Complementary; D006682:HLA-DP Antigens / Q000235:genetics*; D059868:HLA-DP beta-Chains; D006801:Humans; D008969:Molecular Sequence Data; D044465:White People / Q000235:genetics*
D018076:DNA, Complementary; D006682:HLA-DP Antigens; D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen