[Functional role of nur77 family in T-cell apoptosis and stress response].
Nur77 is an orphan member of the steroid receptor superfamily (nuclear receptor). Nur77 family consists of three subtypes and the subtypes show functional redundancy. Nur77 family plays an important role in the apoptotic process of negative selection of T-cells. Moreover, nur77 seems to play a pivotal role in the hypothalamic-pituitary-adrenal axis (HPA axis) during stress response. Nur77 antagonizes the negative feedback effect on the production and secretion of ACTH by glucocorticoid in corticotrope cells of the pituitary gland.
Okabe
T
T
Department of Medicine, National Kyushu Medical Center, Kyushu University.
Nawata
H
H
D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000818:Animals; D017209:Apoptosis; D004268:DNA-Binding Proteins / Q000502:physiology*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D057105:Nuclear Receptor Subfamily 4, Group A, Member 1; D010902:Pituitary Gland / Q000378:metabolism; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D018160:Receptors, Cytoplasmic and Nuclear; D011987:Receptors, Steroid; D013312:Stress, Physiological / Q000503:physiopathology*; D013601:T-Lymphocytes / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*
D004268:DNA-Binding Proteins; C539821:NR4A1 protein, human; D057105:Nuclear Receptor Subfamily 4, Group A, Member 1; D018160:Receptors, Cytoplasmic and Nuclear; D011987:Receptors, Steroid; D014157:Transcription Factors; D000324:Adrenocorticotropic Hormone