Fatal opiates overdose. Toxicological identification of various metabolites in a blood sample by GC-MS after silylation.
A fatal opiates overdose, where ethylmorphine, hydrocodone, dihydrocodeine and codeine were consumed concomitantly, is reported. This case report may contribute to data on fatal blood concentrations of drugs with rare incidence. The relative retention times in capillary gas chromatography and full mass spectra of various opiates in their silylated forms, detected together in one sample, may serve as a helpful analytical reference for clinical and forensic toxicologists.
Institute for Toxicology and Forensic Chemistry, 1st Medical Faculty and Hospital, Charles University, Prague, Czech Republic.
M
M
Balíková
V
V
Maresová
D000328:Adult; D003061:Codeine / Q000031:analogs & derivatives / Q000097:blood / Q000506:poisoning; D062787:Drug Overdose; D005036:Ethylmorphine / Q000097:blood / Q000506:poisoning; D017809:Fatal Outcome; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D006853:Hydrocodone / Q000097:blood / Q000506:poisoning; D008297:Male; D009293:Opioid-Related Disorders / Q000097:blood*; D014116:Toxicology / Q000379:methods
D006853:Hydrocodone; C014481:dihydrocodeine; D005036:Ethylmorphine; D003061:Codeine