Gastrointestinal perforation early after peripheral blood stem cell transplantation for AL amyloidosis.
The morbidity and mortality of AL amyloidosis is caused by the deposition of Ig light chains as amyloid protein in vital organs. With conventional therapy median survival of patients with AL amyloidosis is 10-14 months. With high-dose chemotherapy clinical remissions of organ-specific disease have been reported. Here, we present a patient with high-risk AL amyloidosis who was given high-dose therapy and a peripheral blood stem cell transplant. Four days later she died of gastrointestinal perforation due to amyloid infiltrations.
Department of Medicine I, University of Vienna, Austria.
A
A
Schulenburg
P
P
Kalhs
G
G
Oberhuber
E
E
Reiter
W
W
Base
H T
HT
Greinix
D000328:Adult; D000686:Amyloidosis / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D017809:Fatal Outcome; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007146:Immunoglobulin lambda-Chains / Q000378:metabolism; D007416:Intestinal Perforation / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D014182:Transplantation, Autologous
D007146:Immunoglobulin lambda-Chains