[The naloxone test in the degenerative changes of seminiferous tubules].
OBJECTIVE
Are there any changes in hypophyseal and gonadal hormones levels during the naloxone test in the degenerative changes of the seminiferous tubules?


METHODS
The naloxone test (0.4 mg i.v.) was performed in 13 patients with degenerative changes of the seminiferous tubules. The plasma FSH, LH, prolactin, testosterone and estradiol levels were determined before and 30, 60, 90, 120 minutes after the administration of the drug.


RESULTS
In the examined group of patients the plasma FSH, prolactin and estradiol levels were significantly higher, testosterone levels significantly lower and LH levels were in the same range compared with the patients with azoospermia and normal spermatogenesis. The plasma FSH, prolactin and testosterone levels did not change significantly their values during the test. The plasma estradiol levels decreased significantly and plasma LH levels increased significantly during the test.


CONCLUSIONS
Elevated plasma FSH, prolactin and estradiol levels, diminished testosterone levels and the decrease of plasma estradiol levels and the increase plasma LH levels during the naloxone test indicate the degenerative changes of the seminiferous tubules in the cases of azoospermia.
I Kliniki i I Katedry Połoznictwa i Ginekologii Akademii Medycznej w Warszawie.
L
L
Bablok
S
S
Fracki
M
M
Wielgoś
M
M
Czaplicki
L
L
Marianowski
D000328:Adult; D004958:Estradiol / Q000097:blood / Q000378:metabolism; D005640:Follicle Stimulating Hormone / Q000097:blood / Q000378:metabolism; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000493:pharmacokinetics*; D009845:Oligospermia / Q000175:diagnosis; D011388:Prolactin / Q000097:blood / Q000378:metabolism; D012189:Retrospective Studies; D012671:Seminiferous Tubules / Q000187:drug effects* / Q000473:pathology*
D009292:Narcotic Antagonists; D009270:Naloxone; D004958:Estradiol; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone