Hereditarily elongated carotid sinus nerve in a rat colony.
A specific colony of Wistar rats was found in which the common carotid artery bifurcates at an unusually caudal position, thereby the carotid sinus nerve that originates from the bifurcation is elongated. The present study was done to determine whether this elongated nerve carries baro- and chemosensations in the same manner as the carotid sinus nerve of conventional rats or of other species. In chloralose-urethane anesthetized rats of this specific colony, the afferent discharges were recorded from the elongated carotid sinus nerve in response to a phenylephrine-induced rise in blood pressure and a fall in oxygen tension, as well as an increase in carbon dioxide tension in the respiratory gas. Reflex effects of electrical stimulation of the nerve were also examined. In nerve recording, the afferent discharges of the elongated carotid sinus nerve were increased by any of the perturbations, hypertensive, hypoxic or hypercapnic. Electrical stimulation of the elongated carotid sinus nerve caused an initial rise and a subsequent fall in blood pressure, bradycardia, and an increase of respiratory volume and rate. These results confirmed that the elongated carotid sinus nerve of rats in this colony contains both baroreceptor and chemoreceptor afferent fibers. It seems that this colony of rats proffers a beneficial material which will facilitate the studies to analyze the features and reflex functions of carotid body chemoreceptors and/or carotid sinus baroreceptors.
Department of Physiology, Mie University School of Medicine, Tsu, Japan.
K
K
Tanaka
K
K
Inui
M
M
Kobayashi
S
S
Murase
S
S
Nosaka
D000344:Afferent Pathways / Q000503:physiopathology; D000818:Animals; D002339:Carotid Arteries / Q000473:pathology; D002346:Carotid Sinus / Q000294:innervation*; D002628:Chemoreceptor Cells / Q000503:physiopathology; D004558:Electric Stimulation; D008297:Male; D009421:Nervous System Malformations / Q000235:genetics* / Q000503:physiopathology; D011311:Pressoreceptors / Q000503:physiopathology; D051381:Rats / Q000033:anatomy & histology* / Q000235:genetics*; D017208:Rats, Wistar