The GnRH promoter: target of transcription factors, hormones, and signaling pathways.
Gonadotropin-releasing hormone (GnRH) is essential for normal reproductive maturation and function. We present a review of the known mechanisms of hypothalamic GnRH transcriptional control through the conserved GnRH promoter. Understanding this promoter region will allow us to comprehend better the complexities of the hypothalamic pituitary-gonadal axis.
Department of Reproductive Medicine, The Center for Cellular and Molecular Medicine, University of California, San Diego, La Jolla 92093-0674, USA.
S B
SB
Nelson
S A
SA
Eraly
P L
PL
Mellon
D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism; D005786:Gene Expression Regulation; D007987:Gonadotropin-Releasing Hormone / Q000235:genetics*; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D050816:Octamer Transcription Factor-6; D011401:Promoter Regions, Genetic / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics*; D014157:Transcription Factors / Q000378:metabolism*
D004268:DNA-Binding Proteins; D006728:Hormones; C494178:POU3F1 protein, human; D014157:Transcription Factors; D050816:Octamer Transcription Factor-6; D007987:Gonadotropin-Releasing Hormone