[Expression of fetal antigens of gonocytes in the investigation of pathogenesis of germinal cell neoplasia].
Expression of fetal antigens of germinal cells reacting with antibodies M2A and TRA-1-60 has been studied in fetal germinal cells-gonocytes (G) persisted in gonads of prepubertal boys because of male pseudohermaphroditism (MP) and in germinal carcinoma cells in situ (CIS) of adult men. The presence of G and CIS cells was detected immunohistochemically by identification of placental like alkaline phosphatase (PLAP). CIS cells showed expression of M2A in all adult men and additionally TRA-1-60 in one case. These antigens were present in G cells only in 2 out of 6 G bearing testes of boys with MP (30%). G cells were not found in testes of 3 other older boys with MP. So, in 1/3 cases of children with MP G cells show similar features like CIS cells during the prepubertal period indicating that they are able to enter malignant transformation in early prepubertal testis. Although total frequency of occurrence of G cells in MP boys was 2/3 (60%), their malignant transformation may be lower.
Pracowni Andrologii Klinicznej, Instytutu Endokrynologii AM w Lodzi.
J
J
Słowikowska-Hilczer
R
R
Walczak
M
M
Sosnowski
K
K
Kula
D000951:Antigens, Neoplasm / Q000276:immunology*; D015415:Biomarkers; D002278:Carcinoma in Situ / Q000276:immunology*; D018236:Carcinoma, Embryonal / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D012734:Disorders of Sex Development / Q000276:immunology; D005854:Germ Cells / Q000276:immunology*; D018237:Germinoma / Q000276:immunology*; D006801:Humans; D007223:Infant; D008297:Male; D013736:Testicular Neoplasms / Q000276:immunology*; D013737:Testis / Q000276:immunology*
D000951:Antigens, Neoplasm; D015415:Biomarkers