The antioxidant N-acetylcysteine does not delay disease onset and death in a transgenic mouse model of amyotrophic lateral sclerosis.
Jaarsma
D
D
Guchelaar
H J
HJ
Haasdijk
E
E
de Jong
J M
JM
Holstege
J C
JC
D000111:Acetylcysteine / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D000284:Administration, Oral; D000690:Amyotrophic Lateral Sclerosis / Q000188:drug therapy* / Q000235:genetics; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D018450:Disease Progression; D016166:Free Radical Scavengers / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D006207:Half-Life; D051379:Mice; D008822:Mice, Transgenic; D017354:Point Mutation / Q000187:drug effects; D014810:Vitamin E / Q000494:pharmacology
D016166:Free Radical Scavengers; D014810:Vitamin E; D000111:Acetylcysteine