Reduced IL-1 production in adolescents with mite antigen asthma in remission.
To determine the immunological mechanisms associated with outgrowing mite antigen-induced bronchial asthma during adolescence, we studied the relationship between clinical status and Dermatophagoides farinae (Df) antigen-induced peripheral cell activation by measuring IL-1alpha and IL-1beta production in patients with bronchial asthma. After antigen-driven restimulation in vitro, there was increased IL-1alpha, IL-1beta production by peripheral blood mononuclear cells (PBMC) from patients with active bronchial asthma, while cellular IL-1alpha, IL-1beta production was reduced in patients with asthma in remission. IL-1alpha and IL-1beta production by PBMC (possibly reflecting airway inflammation) after exposure to Df antigen might be down-regulated in patients outgrowing mite antigen-induced asthma, because lipopolysaccharide-induced IL-1alpha, IL-1beta production (seen in both normal individuals and patients with active asthma) was also reduced when patients were in remission.
Department of Pediatrics, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
T
T
Noma
K
K
Ichikawa
I
I
Yoshizawa
K
K
Aoki
Y
Y
Kawano
M
M
Baba
D000293:Adolescent; D000328:Adult; D000818:Animals; D039741:Antigens, Dermatophagoides; D001249:Asthma / Q000276:immunology* / Q000628:therapy; D002478:Cells, Cultured; D005260:Female; D006023:Glycoproteins / Q000276:immunology*; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D008925:Mites; D009000:Monocytes / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D012074:Remission Induction
D039741:Antigens, Dermatophagoides; D006023:Glycoproteins; D007375:Interleukin-1; D008070:Lipopolysaccharides