Fission yeast cut mutations revisited: control of anaphase.
Studies of anaphase are approaching a golden age. Several different disciplines have contributed immensely to advances in our understanding of cell-cycle control and chromosome and spindle dynamics during mitosis. This article describes control of anaphase based on results obtained from Schizosaccharomyces pombe cut (cell untimely torn) mutants. These temperature-sensitive mutants were isolated by selection for uncoordinated mitosis with aberrant sister-chromatid separation and post-anaphase events. Characterization of some of the cut gene products has led to identification of novel molecular events related to chromosome condensation, sister-chromatid separation, anaphase-promoting proteolysis, fatty-acid metabolism, and cell-cycle arrest induced by stress or a replication block.
Dept of Biophysics, Graduate School of Science, Kyoto University, Japan. yanagida@kozo.biophys.kyoto-u.ac.jp
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D000705:Anaphase / Q000235:genetics*; D018797:Cell Cycle Proteins / Q000235:genetics*; D009154:Mutation; D012568:Schizosaccharomyces / Q000166:cytology / Q000235:genetics* / Q000502:physiology
D018797:Cell Cycle Proteins