On the kinetic theory of the extracellular signal transduction in native cells: I. Hormone-receptor interaction.
The hormone-receptor interaction is reconsidered and a minimal kinetic theory for the signal transduction in native cells is proposed. The basic equation for the time evolution of the concentration of the hormone-receptor complex is obtained. It is shown, that the hormone-receptor interaction is regulated by a cycle of G protein, i.e. kinetic parameters associated with the G protein cycle enter this equation. The existence of exponential and oscillatory regimes in kinetics of the G protein cycle, and hormone-receptor interactions are predicted. Experimental kinetic curves for agonist binding are computer-simulated, and numerical values for various kinetic and equilibrium parameters are obtained.
Center for Studies in Statistical Mechanics and Complex Systems, University of Texas at Austin 78712, USA.
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D016308:Enkephalin, Leucine-2-Alanine / Q000378:metabolism; D005110:Extracellular Space / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000502:physiology; D006728:Hormones / Q000378:metabolism / Q000502:physiology*; D007700:Kinetics; D008432:Mathematical Computing; D009447:Neuroblastoma / Q000378:metabolism / Q000648:ultrastructure; D011956:Receptors, Cell Surface / Q000378:metabolism / Q000502:physiology*; D017465:Receptors, Opioid, delta / Q000819:agonists / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D014316:Tritium; D014407:Tumor Cells, Cultured
D006728:Hormones; D011956:Receptors, Cell Surface; D017465:Receptors, Opioid, delta; D014316:Tritium; D016308:Enkephalin, Leucine-2-Alanine; D019204:GTP-Binding Proteins