Immune dysfunction and the pathogenesis of AIDS-associated non-Hodgkin's lymphoma.
Much has been learned about how HIV-induced immune dysfunction contributes to B cell hyperactivation, and potentially, to the pathogenesis of AIDS-lymphoma. However, further studies are needed to fully understand how HIV infection and immune dysfunction promote B cell hyperactivation and the development/growth of AIDS-lymphoma. In particular, studies are needed to define the role of HHV8 vIL6, IL6 receptor-expression, and lymphocyte surface stimulatory molecules, in promoting B cell hyperactivation or lymphoma cell growth.
Department of Microbiology, UCLA School of Medicine 90095-1747, USA.
O
O
Martínez-Maza
D
D
Widney
M
M
van der Meijden
R
R
Knox
A
A
Echeverri
E C
EC
Breen
L
L
Magpantay
S A
SA
Miles
D001402:B-Lymphocytes / Q000473:pathology*; D002455:Cell Division / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D019288:Herpesvirus 8, Human / Q000276:immunology / Q000472:pathogenicity; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000276:immunology* / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology* / Q000473:pathology; D019947:Receptors, Interleukin-6 / Q000276:immunology
D016207:Cytokines; D019947:Receptors, Interleukin-6