Butyrylcholinesterase K variant and apolipoprotein E4 genes do not act in synergy in Finnish late-onset Alzheimer's disease patients.
Examination of the allelic frequency of the butyrylcholinesterase K (BChE-K) variant gene revealed no increase among Finnish late-onset Alzheimer's disease (AD) patients either as a whole or among a subset of AD patients carrying the epsilon4 allele of apolipoprotein E (ApoE4). In contrast, BChE-K allele frequency was significantly reduced in the Finnish AD patient group under 75 years of age carrying the ApoE4 allele when compared to the non-demented controls (chi2, P < 0.05). The proportion of subjects with both BChE-K and ApoE4 alleles was 14% and 41% in AD and control groups, respectively (chi2, P < 0.01; odds-ratio 0.22, 95% CI 0.07-0.71). These results are in contrast to a previous study on English AD patients, in which the genes for BChE-K and ApoE4 were suggested to act in synergy.
Department of Neurology, University Hospital and University of Kuopio, Finland. mhiltune@messi.uku.fi
M
M
Hiltunen
A
A
Mannermaa
S
S
Helisalmi
A
A
Koivisto
M
M
Lehtovirta
M
M
Ryynänen
P
P
Riekkinen
H
H
Soininen
D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D002091:Butyrylcholinesterase / Q000235:genetics*; D005260:Female; D005387:Finland; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D002091:Butyrylcholinesterase