Stabilization of deoxyadenosine/polynucleotide complexes by 3',5'-di-O-benzoyl substituents.
3',5'-Di-O-benzoyldeoxyadenosine forms stable dT:dA:dT type complexes with poly(dT) and an oligo(dT)-cholesteryl conjugate in dilute aqueous solution. The benzoyl groups play an essential role in stabilizing these "triple stranded" complexes.
Department of Chemistry, Northwestern University, Evanston, IL 60208, USA.
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Chaturvedi
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RL
Letsinger
D000241:Adenosine / Q000031:analogs & derivatives; D002784:Cholesterol / Q000737:chemistry; D002942:Circular Dichroism; D003839:Deoxyadenosines / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D011061:Poly A / Q000737:chemistry*; D011071:Poly T / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D013053:Spectrophotometry; D013696:Temperature
D003839:Deoxyadenosines; D009838:Oligodeoxyribonucleotides; D011061:Poly A; D011071:Poly T; C015465:poly(dA); D002784:Cholesterol; D000241:Adenosine