Pharmacological and functional implications of developmentally-regulated changes in GABA(A) receptor subunit expression in the cerebellum.
The cerebellum undergoes many morphological, pharmacological, and electrophysiological changes during the first 3 weeks of postnatal development. The purpose of this review is to present the most up to date synopsis of the pharmacological and functional changes in, gamma-aminobutyric acid (GABA) type A receptors during this time of cerebellar maturation. Since most of the diversity in cerebellar, GABA(A) receptor pharmacology lies within the granule cell layer, research groups have focused on this area of the cerebellum to study the developmental changes in GABA(A) receptor subunit expression and the neurodifferentiating factors involved in regulating this expression. Thus, it is important to note that developmental changes in GABA(A) receptor composition and its corresponding pharmacology will be essential for determining the type of GABA-mediated transmission that occurs between neuronal contacts in the neonatal and subsequently in the mature cerebellum.
PharmaBiotec Research Center, Dept. of Pharmacology, The Royal Danish School of Pharmacy, Copenhagen.
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Carlson
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Elster
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Schousboe
D000818:Animals; D002531:Cerebellum / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D018682:GABA Agents / Q000494:pharmacology; D006801:Humans; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000378:metabolism
D018682:GABA Agents; D011963:Receptors, GABA-A