Preliminary experience of the DIAS computer model in providing insulin dose advice to patients with insulin dependent diabetes.
The Diabetes Advisory System (DIAS) is a model of human glucose metabolism which predicts hourly blood glucose concentrations and provides advice on insulin dose. Its ability to provide appropriate advice was assessed in 20 well-controlled IDDM patients (mean (SD) age 38 (11), duration 17 (9) years; HbA1 8.8 (0.9)%, reference range 5.4-7.6%). Patients recorded blood glucose measurements, insulin dose and food intake for 4 days. These data were used to generate insulin dose advice by both DIAS and a diabetes specialist nurse. Patients were then allocated to follow either DIAS or nurse advice for a further 4 days. There was no significant difference in mean recorded blood glucose values or frequency of reported hypoglycaemia between the DIAS and nurse groups either before or after insulin dose adjustment. The DIAS model, however, generated significantly lower insulin dose advice than the nurse (median (range)% change in insulin dose: DIAS group -13.3% (-25.0 to +11.6) versus nurse group 0% (-8.7 to +2.5), P < 0.05). We conclude that, in the patients studied, DIAS provided insulin dose advice which maintained good short term control of diabetes, despite significant reductions in dose in some cases.
Cavan
D A
DA
Department of Endocrinology, St Thomas' Hospital, London, UK. d.cavan@rbch-tr.swest.nhs.uk
Hejlesen
O K
OK
Hovorka
R
R
Evans
J A
JA
Metcalfe
J A
JA
Cavan
M L
ML
Halim
M
M
Andreassen
S
S
Carson
E R
ER
Sönksen
P H
PH
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D003198:Computer Simulation; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004360:Drug Therapy, Computer-Assisted; D005069:Evaluation Studies as Topic; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D007328:Insulin / Q000008:administration & dosage* / Q000627:therapeutic use; D008954:Models, Biological
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin