Endothelin-1 in the superior colliculus of rats induces depressor responses due to peripheral hemodynamic changes.
Microinjection of endothelin-1 (ET-1; 10 pmol) into the superficial layer of the superior colliculus caused systemic and regional hemodynamic changes, as measured by injection of radioactive microspheres at the peak of the hypotensive effect of endothelin-1. Endothelin-1 decreased total peripheral resistance by 39 +/- 2% (n=5); the vascular resistances were decreased in the spleen, the mesentery, the large intestine and the small intestine. Moreover, we found that in consequence of the increased fraction of cardiac output received by the above organs, decreases in vascular resistances were associated with increases in blood flows in them. Interestingly, ET-1 also decreased the vascular resistances and increased the total blood flows in the kidneys. The haemodynamic changes induced by injection of endothelin-1 to the superior colliculus were associated with significant decreases in the mean arterial blood pressure (37 +/- 4 mmHg, n=6) and no changes in heart rate. Exogenous ET-1, therefore, within the SC decreases blood pressure due to peripheral hemodynamic changes.
Institute of Pharmacology and Toxicology, Faculty of Medicine and Surgery, II University of Naples, Italy.
M
M
D'Amico
C
C
Di Filippo
F
F
Rossi
D000818:Animals; D019332:Endothelin-1 / Q000008:administration & dosage / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D008845:Microinjections; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000187:drug effects; D013477:Superior Colliculi / Q000187:drug effects*; D014655:Vascular Resistance / Q000187:drug effects
D019332:Endothelin-1