Coexistence of Fabry's disease and systemic lupus erythematosus.
This report describes a case of a female with systemic lupus erythematosus, who was subsequently diagnosed with Fabry's disease. Due to similarities in the organs involved by these two multisystem disorders, difficulties were encountered in establishing a prompt diagnosis of Fabry's disease. That and subsequent management of this patient are discussed. A literature review of the coexistence of the two disorders along with the potential pathogenic mechanisms explaining this association are explored.
University of Toronto Psoriatic Arthritis Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Ontario, Canada.
P
P
Rahman
D D
DD
Gladman
J
J
Wither
M D
MD
Silver
D004699:Endocardium / Q000648:ultrastructure; D000795:Fabry Disease / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006028:Glycosphingolipids / Q000652:urine; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D008247:Lysosomes / Q000378:metabolism / Q000648:ultrastructure; D008875:Middle Aged; D009206:Myocardium / Q000648:ultrastructure; D000519:alpha-Galactosidase / Q000378:metabolism
D006028:Glycosphingolipids; C088880:ceramide trihexoside; D000519:alpha-Galactosidase