The GAIA software framework for genome annotation.
We describe a software framework, GAIA, that supports semi-automated annotation of uncharacterized sequence data. The annotation framework incorporates annotation by data source integration, data analysis, and manual data entry. Components of the system include a configurable, open data analysis pipeline, a relational information storage manager, and Java-based graphical user interfaces. We discuss design decisions and tradeoffs in building such a system, and policies and strategies for producing consistent, uniform, high quality annotation.
Center for Bioinformatics, University of Pennsylvania, Philadelphia 19104, USA.
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Overton
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Bailey
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Crabtree
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Gibson
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Fischer
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Schug
D001483:Base Sequence; D002892:Chromosomes, Human, Pair 22; D019295:Computational Biology / Q000379:methods*; D003196:Computer Graphics; D020224:Expressed Sequence Tags; D016678:Genome; D015894:Genome, Human; D006801:Humans; D008957:Models, Genetic; D020161:Physical Chromosome Mapping / Q000379:methods; D012984:Software; D013698:Templates, Genetic