Phagocytes in ischemia injury.
We are now developing the means to evaluate components of this inflammatory response that may facilitate healing. A key event in the change in the inflammatory response is the development of a cytokine cascade that promotes phenotypic changes in the infiltrating leukocytes, which endow them with the ability to promote fibroblast proliferation and collagen deposition, the hallmarks of healing.
Methodist Hospital, DeBakey Heart Center, Department of Medicine, Philadelphia, Pennsylvania, USA.
K A
KA
Youker
H H
HH
Birdsall
N G
NG
Frangogiannis
A G
AG
Kumar
M L
ML
Lindsey
C M
CM
Ballantyne
C W
CW
Smith
R D
RD
Rossen
M L
ML
Entman
D000818:Animals; D002634:Chemotaxis, Leukocyte; D003326:Coronary Circulation / Q000502:physiology*; D004285:Dogs; D005260:Female; D005434:Flow Cytometry; D006636:Histamine Release; D007963:Leukocytes, Mononuclear / Q000502:physiology; D008196:Lymph / Q000276:immunology; D008297:Male; D009000:Monocytes / Q000502:physiology; D017202:Myocardial Ischemia / Q000097:blood / Q000276:immunology / Q000503:physiopathology*; D015425:Myocardial Reperfusion; D009206:Myocardium / Q000378:metabolism; D010586:Phagocytes / Q000502:physiology*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D014409:Tumor Necrosis Factor-alpha