Cell adhesion molecules in cord blood hematopoietic progenitors.
We investigated the expression of different cell adhesion molecules on cord blood (CB) and bone marrow (BM) CD34+/CD38+ and CD34+/CD38- cells. CD11a and CD62L were more expressed in CB than in BM CD34+/CD38- subset, suggesting a possible advantage in homing and engraftment. A short exposure to various cytokines increased CD62L expression only in the more differentiated CB and BM CD34+/CD38+ cells.
Dept of Ped Hematology/Oncology, University of Turin, Torino, Italy.
F
F
Timeus
N
N
Crescenzio
D
D
Marranca
M
M
Dall'Aglio
L
L
Fazio
M
M
Di Marco
P
P
Saracco
M
M
Ricotti
V
V
Gabutti
D036541:ADP-ribosyl Cyclase; D051997:ADP-ribosyl Cyclase 1; D015703:Antigens, CD; D018952:Antigens, CD34 / Q000032:analysis; D000943:Antigens, Differentiation / Q000032:analysis; D001854:Bone Marrow Cells / Q000737:chemistry / Q000166:cytology*; D015815:Cell Adhesion Molecules / Q000032:analysis*; D005312:Fetal Blood / Q000737:chemistry / Q000166:cytology*; D005434:Flow Cytometry; D006412:Hematopoietic Stem Cells / Q000737:chemistry*; D006801:Humans; D019041:L-Selectin / Q000032:analysis; D016169:Lymphocyte Function-Associated Antigen-1 / Q000032:analysis; D008562:Membrane Glycoproteins; D009244:NAD+ Nucleosidase / Q000032:analysis
D015703:Antigens, CD; D018952:Antigens, CD34; D000943:Antigens, Differentiation; D015815:Cell Adhesion Molecules; D016169:Lymphocyte Function-Associated Antigen-1; D008562:Membrane Glycoproteins; D019041:L-Selectin; D036541:ADP-ribosyl Cyclase; C498154:CD38 protein, human; D009244:NAD+ Nucleosidase; D051997:ADP-ribosyl Cyclase 1