Arnold-Chiari malformation in a captive African lion cub.
Progressive ataxia, delayed growth, dementia and tremors were noted in a female African lion (Panthera leo) cub at the Tel-Aviv Ramat-Gan Zoological Center (Israel). The lioness was 3-mo-old when clinical signs were first noticed. Repeated neurological evaluations and blood tests were conducted in an attempt to establish a diagnosis. A congenital abnormality was suspected and the lioness died 6 molater. Post mortem examination revealed an Arnold-Chiari malformation. The abnormality was classified as a Chiari type 2 malformation, based on the herniation of the cerebellar vermis and paravermis and the slight caudal displacement of the medulla, combined with lack of displacement in other parts of the brainstem.
Shamir
M H
MH
Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel. shamir@agri.huji.ac.il
Horowitz
I H
IH
Yakobson
B
B
Ofri
R
R
D000818:Animals; D001139:Arnold-Chiari Malformation / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D001259:Ataxia / Q000662:veterinary; D001921:Brain / Q000473:pathology; D003704:Dementia; D003937:Diagnosis, Differential; D005260:Female; D008045:Lions / Q000002:abnormalities*; D008297:Male; D009460:Neurologic Examination / Q000662:veterinary; D014202:Tremor / Q000662:veterinary