Loop diuretics in patients aged 75 years or older: general practitioners' assessment of indications and possibilities for withdrawal.
OBJECTIVE
To examine the indications for prescription and possibilities for withdrawal of loop diuretics in community-dwelling patients aged 75 years or older, as reported by their general practitioners (GPs).


METHODS
Analysis of dispensary data to identify patients aged 75 years or older using loop diuretics on 1 February 1996. Questionnaires were sent to the GPs of these patients to inquire about the indications for loop diuretic prescription and the necessity for continuation. We subsequently determined loop diuretic prescription rates in the survey population over the next 9 months.


METHODS
A panel of nine Dutch community pharmacies.


RESULTS
Questionnaires were returned for 338 out of 667 patients (50.7%) using loop diuretics on 1 February 1996. Reported indications for loop diuretic use were heart failure in 223 patients (66.0%), hypertension in 35 patients (10.4%), and a combination of both in 23 patients (6.8%). Loop diuretics were used for ankle edema in 27 patients (8.0%) and for unknown reasons in another 27 patients (8.0%). Continuation of treatment was considered unnecessary by GPs in 66 out of 338 patients (19.5%). However, prescription rates for these 66 patients in the following months were no different from rates for the remaining 272 patients. Loop diuretics were still prescribed to 47 of 66 patients (71.2%) after 12 weeks, and to 26 patients (39.4%) after 36 weeks.


CONCLUSIONS
GPs reported substantial opportunities for withdrawal of loop diuretics in patients over 75 years of age, but this did not influence actual prescription rates in these patients. Future studies should explore means of facilitating withdrawal of these medications in this population.
Department of Clinical Pharmacology, University Hospital Nijmegen, The Netherlands.
D J
DJ
van Kraaij
R W
RW
Jansen
F W
FW
Gribnau
W H
WH
Hoefnagels
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D004232:Diuretics / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006333:Heart Failure / Q000188:drug therapy; D006801:Humans; D008297:Male; D009426:Netherlands; D010821:Physicians, Family
D004232:Diuretics