Interferon-gamma and human megakaryopoiesis.
Interferon-gamma (IFN-gamma) exhibits various properties including antigrowth activity in neoplastic and normal cells and regulatory roles in immune responses and hematopoiesis, but studies of IFN-gamma effects on human megakaryopoiesis have been inconclusive. Recently we have used serum-free culture of purified CD34+ cells to demonstrate that IFN-gamma stimulates the proliferation of relatively mature megakaryocytic progenitors independently of thrombopoietin. It has been also shown that IFN-gamma stimulates the maturation of megakaryocytes, and has a significant synergism with stem cell factor in human megakaryopoiesis. Further studies are needed to clarify the in vivo effect of IFN-gamma on human megakaryopoiesis and the clinical relevance of IFN-gamma.
Department of Clinical Oncology, The Institute of Medical Science, The University of Tokyo, Japan.
K
K
Tsuji
K
K
Muraoka
T
T
Nakahata
D016922:Cellular Senescence / Q000187:drug effects; D016207:Cytokines / Q000494:pharmacology; D004357:Drug Synergism; D006402:Hematologic Diseases / Q000188:drug therapy; D006410:Hematopoiesis / Q000187:drug effects*; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology*; D008533:Megakaryocytes / Q000187:drug effects*
D016207:Cytokines; D007371:Interferon-gamma