[Immune response of elderly persons depending on the number of annual seasonal immunizations of live and inactivated influenza vaccines].
A total of 159 subjects aged 65-87 years were immunized with live cold-adapted reassortant influenza vaccine (CRIV), inactivated influenza vaccine (IIV), and with both vaccines (CRIV + IIV) one year, two and three years running. The frequency and intensity of accumulation of postvaccinal secretory and humoral antibodies in elderly subjects depend on the scheme of immunization and history of vaccinations. Combination of the two vaccines effectively stimulated both components of immunity and ensured a longer persistence of postvaccinal antibodies in high concentrations. Immunization with CRIV + IIV for three years resulted in a gradual increase of the intensity of prevaccination secretory and humoral immunity. Before the third seasonal immunization the majority (63-75%) of vaccinees had antibodies in protective titers.
Naĭkhin
A N
AN
Rudenko
L G
LG
Arden
N
N
Katz
J
J
Grigor'eva
E P
EP
Donina
S A
SA
Lesheva
Iu A
IuA
Rekstin
A R
AR
Cox
N
N
D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000096:biosynthesis / Q000097:blood; D006801:Humans; D007070:Immunoglobulin A / Q000096:biosynthesis / Q000097:blood; D007252:Influenza Vaccines / Q000276:immunology*; D012621:Seasons; D015164:Vaccines, Inactivated / Q000276:immunology*
D000914:Antibodies, Viral; D007070:Immunoglobulin A; D007252:Influenza Vaccines; D015164:Vaccines, Inactivated