Design and self-assembly of two-dimensional DNA crystals.
Molecular self-assembly presents a 'bottom-up' approach to the fabrication of objects specified with nanometre precision. DNA molecular structures and intermolecular interactions are particularly amenable to the design and synthesis of complex molecular objects. We report the design and observation of two-dimensional crystalline forms of DNA that self-assemble from synthetic DNA double-crossover molecules. Intermolecular interactions between the structural units are programmed by the design of 'sticky ends' that associate according to Watson-Crick complementarity, enabling us to create specific periodic patterns on the nanometre scale. The patterned crystals have been visualized by atomic force microscopy.
Winfree
E
E
Computation and Neural Systems, California Institute of Technology, Pasadena 91125, USA. winfree@hope.caltech.edu
Liu
F
F
Wenzler
L A
LA
Seeman
N C
NC
D001483:Base Sequence; D003460:Crystallization; D004247:DNA / Q000138:chemical synthesis / Q000737:chemistry*; D004591:Electrophoresis, Polyacrylamide Gel; D018625:Microscopy, Atomic Force; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D013499:Surface Properties
D004247:DNA