Prevention of postoperative pericardial adhesions with a defibrinogenating agent.
Pericardial adhesions pose a major problem during re-operative cardiac surgical procedures. The purpose of this study was to determine the effect of Batroxobin, a fibrinogen depleting agent, on the incidence of experimental pericardial adhesions. Twenty-four rabbits were divided into 3 groups of 8 rabbits each and pericardial mesothelial injury was induced by abrasion. Group A included rabbits receiving no further treatment, Group B included rabbits receiving intrapericardial injection of Ringer's solution, and Group C included rabbits receiving intrapericardial injection of Batroxobin. Three weeks after surgery, the incidence of adhesions in Groups B and C was compared with that in Group A. Pericardial adhesions found in 80% of the rabbits in Groups A and B. However, only 14% of the rabbits in Group C had pericardial adhesions (p < 0.05). Our findings demonstrated that intrapericardial Batroxobin reduced the incidence of pericardial adhesions in an animal model.
Hioki
M
M
Second Department of Surgery, Nippon Medical School, Tokyo, Japan.
Iedokoro
Y
Y
Yamagishi
S
S
Yamashita
Y
Y
Orii
K
K
Hirano
S
S
Hirata
T
T
Masuda
S
S
Kutukata
N
N
Hisayoshi
T
T
Tanaka
S
S
D000818:Animals; D012103:Batroxobin / Q000627:therapeutic use*; D016009:Chi-Square Distribution; D004195:Disease Models, Animal; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D010496:Pericardium / Q000473:pathology*; D011183:Postoperative Complications / Q000517:prevention & control*; D011817:Rabbits; D000267:Tissue Adhesions / Q000473:pathology / Q000517:prevention & control
D005343:Fibrinolytic Agents; D012103:Batroxobin