Src phosphorylates EAST, a novel EGF receptor-associated protein.
We have recently found and characterized EAST, a novel EGF receptor-associated protein with SH3 and TAM domains. In this study we show that EAST becomes phosphorylated by Src kinase. This, in conjunction with our earlier observations on the close association between EAST and the endocytic machinery, suggests that EAST could be involved in Src-dependent effects on EGF receptor endocytosis.
Department of Pathology, University of Oulu, Finland.
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D000818:Animals; D001665:Binding Sites; D002460:Cell Line; D066246:ErbB Receptors / Q000378:metabolism*; D015151:Immunoblotting; D015688:Oncogene Protein pp60(v-src) / Q000276:immunology / Q000378:metabolism*; D010750:Phosphoproteins / Q000737:chemistry / Q000276:immunology / Q000378:metabolism*; D010766:Phosphorylation; D011233:Precipitin Tests; D013696:Temperature; D014443:Tyrosine / Q000737:chemistry / Q000378:metabolism; D018909:src Homology Domains
C485250:EAST protein, human; D010750:Phosphoproteins; D014443:Tyrosine; D066246:ErbB Receptors; D015688:Oncogene Protein pp60(v-src)