[Repair processes in human cultured cells upon exposure to nickel salts and their modification].
The genetic activity of nickel sulfate was estimated from the viability, decreased DNA replication, and increased DNA repair synthesis in cultured human fibroblasts and peripheral blood lymphocytes. All but the viability tests showed the mutagenic effect of nickel sulfate. Pretreatment with ascorbic acid modified DNA repair synthesis and increased the viability of lymphocytes treated with nickel sulfate.
Osipova
T B
TB
Institute of the Problems of Industrial Ecology of the North, Kola Research Center, Russian Academy of Sciences, Apatity, Russia.
Sinel'shchikova
T A
TA
Perminova
I N
IN
Zasukhina
G D
GD
D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004260:DNA Repair; D004261:DNA Replication / Q000187:drug effects; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects*; D009153:Mutagens / Q000633:toxicity*; D009532:Nickel / Q000633:toxicity*
D009153:Mutagens; C029938:nickel sulfate; D009532:Nickel