Integrin-mediated signalling of gelatinase B secretion in colon cancer cells.
The progression of colon cancer has been linked to both cell adhesion molecules called integrins and matrix-degrading enzymes called metalloproteinases. Herein we report that the alpha v beta 6 integrin expressed in colon cancer cells induces gelatinase B secretion through the C-terminal cytoplasmic extension unique to the beta 6 integrin subunit, and that this ligand-independent event involves activation of the protein-kinase-C pathway.
Discipline of Surgical Science, Faculty of Medicine and Health Sciences, University of Newcastle, New South Wales, Australia.
J
J
Niu
X
X
Gu
J
J
Turton
C
C
Meldrum
E W
EW
Howard
M
M
Agrez
D000951:Antigens, Neoplasm; D017364:Collagenases / Q000378:metabolism*; D003110:Colonic Neoplasms / Q000378:metabolism*; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D008024:Ligands; D020780:Matrix Metalloproteinase 9; D015398:Signal Transduction; D014407:Tumor Cells, Cultured
D000951:Antigens, Neoplasm; D016023:Integrins; D008024:Ligands; C073878:integrin alphavbeta6; D017364:Collagenases; D020780:Matrix Metalloproteinase 9