Bone Marrow Donors Worldwide and cord blood stem cell transplantation.
Stem cell transplantation using cord blood donors mismatched for one or two HLA antigens can be successful. A simulation study was performed to assess the percentage of patients for whom a matched and/or a one or two antigen mismatched donor is available. Using either bone marrow donors worldwide (BMDW) (n = 925109) or the cord blood donor file in BMDW (n = 11049). As a donor source, for 97% of the Dutch patients a 0 or 1 antigen mismatched cord blood donor was available, for patients from the minority groups this percentage was 55%. These percentages compare favourably with the fraction of 0 mismatched donors found in BMDW.
van Rood
J J
JJ
Department of Immunohematology and Blood Bank, The Netherlands.
Schipper
R F
RF
Bakker
J N
JN
van der Zanden
H G
HG
Oudshoorn
M
M
D001771:Blood Banks; D016026:Bone Marrow Transplantation / Q000706:statistics & numerical data; D016208:Databases, Factual; D005312:Fetal Blood; D006239:Haplotypes; D018380:Hematopoietic Stem Cell Transplantation / Q000706:statistics & numerical data; D006650:Histocompatibility Testing; D006801:Humans; D012042:Registries; D014019:Tissue Donors / Q000706:statistics & numerical data