Pathological laughter following intravenous sodium valproate.
BACKGROUND
Pathological laughter can be a sign of epilepsy, psychiatric illness, effect of toxins or psychotropic drugs or of structural brain disease.


METHODS
Case Studies.


RESULTS
Two patients developed inappropriate uncontrollable laughter following intravenous sodium valproate for treatment of epilepsy.


CONCLUSIONS
Pathological laughter can be a side effect of intravenous sodium valproate.
Jacob
P C
PC
Department of Medicine (Neurology), College of Medicine, Sultan Qaboos University, Muscat, Oman.
Chand
R P
RP
D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007275:Injections, Intravenous; D007845:Laughter / Q000523:psychology*; D008297:Male; D001523:Mental Disorders / Q000139:chemically induced* / Q000523:psychology*; D012640:Seizures / Q000150:complications / Q000188:drug therapy / Q000523:psychology; D014635:Valproic Acid / Q000008:administration & dosage / Q000009:adverse effects*
D000927:Anticonvulsants; D014635:Valproic Acid