N-terminal processing: the methionine aminopeptidase and N alpha-acetyl transferase families.
Removal of the initiator methionine and/or acetylation of the alpha-amino group are among the earliest possible chemical modifications that occur during protein synthesis in eukaryotes. These events are catalyzed by methionine aminopeptidase and N alpha-acetyltransferase, respectively. Recent advances in the isolation and characterization of these enzymes indicate that they exist as isoforms that vary in cellular location, function, and evolutionary origins.
Dept of Physiology and Biophysics, College of Medicine, University of California, Irvine 92697, USA.
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Bradshaw
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Brickey
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Walker
D000123:Acetyltransferases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000626:Aminopeptidases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D019143:Evolution, Molecular; D006801:Humans; D063208:Methionyl Aminopeptidases; D008958:Models, Molecular; D011487:Protein Conformation; D011499:Protein Processing, Post-Translational
D000123:Acetyltransferases; D000626:Aminopeptidases; D063208:Methionyl Aminopeptidases