Determination of antibiotics in different water compartments via liquid chromatography-electrospray tandem mass spectrometry.
For the determination of 18 antibiotics in water samples down to the lower ng/l range, an analytical multi method is presented. The analytes belong to different groups of antibiotics such as penicillins, tetracyclines, sulfonamides and macrolid antibiotics. Samples were enriched using a universal freeze-drying procedure or a solid-phase extraction facultatively. Analysis was performed by liquid chromatography with electrospray-tandem MS detection. Chromatography required different columns and eluents. Mean recovery rates were in excess of 70%, however, with one exception and a quantitation limit of 50 ng/l for the tetracyclines and 20 ng/l for all other antibiotics were set.
ESWE Institute for Water Research and Water Technology, Wiesbaden, Germany.
R
R
Hirsch
T A
TA
Ternes
K
K
Haberer
A
A
Mehlich
F
F
Ballwanz
K L
KL
Kratz
D000900:Anti-Bacterial Agents / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D005612:Freeze Drying; D013058:Mass Spectrometry; D014867:Water / Q000737:chemistry
D000900:Anti-Bacterial Agents; D014867:Water