Increased serum concentrations of interleukin-10 in patients with hepatosplenic candidiasis.
Hepatosplenic candidiasis (HSC) becomes clinically overt in cancer patients upon recovery from neutropenia. HSC may be a consequence of a Th1-Th2 imbalance, characterized by increased serum levels of one or more cytokines. Serum levels of two immunosuppressive cytokines, markers of the Th2 pathway, interleukin (IL)-4 and IL-10 were measured by ELISA in 10 patients with HSC (22 samples) and compared with 19 healthy blood donors, 13 patients with cancer but no infection (23 samples), and 11 patients with cancer and various bacterial infections (17 samples). IL-4 was undetectable in all controls and patients. By contrast, levels of IL-10 were increased in HSC patients compared with levels in healthy donors and cancer patients without infection (P < .001) or with bacterial infections (P < .01). These findings indicate that IL-10 but not IL-4 is increased in patients with HSC and suggest that IL-10 plays a role in the pathogenesis of this infection.
Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
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Roilides
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Sein
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Schaufele
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Chanock
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Walsh
D002177:Candidiasis / Q000097:blood* / Q000276:immunology; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D015847:Interleukin-4 / Q000097:blood; D008107:Liver Diseases / Q000097:blood* / Q000276:immunology / Q000382:microbiology; D013158:Splenic Diseases / Q000097:blood* / Q000276:immunology / Q000382:microbiology
D016753:Interleukin-10; D015847:Interleukin-4