[Certain biochemical features of leukocytes in blast crisis of chronic myelogenous leukemia].
The content of nuclear high mobility group (HMG) proteins, activities of ornithine decarboxylase (ODC), adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) and also glycosaminoglycan (GAG) content and composition were studied in leukocytes of patients with chronic myelogenous leukemia in the phase of blast crisis (BC CML). Myeloid and lymphoid cytochemical variants of BC CML differ by biochemical parameters. It is suggested, that the content of HMG-proteins, activities of ODC and PNP, and electrophoretic patterns of GAGs could be used in diagnostics of two main variants of BC CML.
Russian Research Institute of Hematology and Transfusiology, St. Petersburg.
M F
MF
Kharchenko
L P
LP
Rybakova
L I
LI
Filanovskaia
L B
LB
Saltykova
E S
ES
Bitiukova
E G
EG
Shcherbakova
O A
OA
Rukavitsyn
S S
SS
Bessmel'tsev
K M
KM
Abdulkadyrov
M M
MM
Blinov
D001752:Blast Crisis / Q000097:blood* / Q000201:enzymology; D006025:Glycosaminoglycans / Q000097:blood; D006609:High Mobility Group Proteins / Q000097:blood; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood* / Q000201:enzymology; D007962:Leukocytes / Q000201:enzymology / Q000378:metabolism*; D009955:Ornithine Decarboxylase / Q000097:blood; D011683:Purine-Nucleoside Phosphorylase / Q000097:blood
D006025:Glycosaminoglycans; D006609:High Mobility Group Proteins; D011683:Purine-Nucleoside Phosphorylase; D009955:Ornithine Decarboxylase