Control of cell proliferation by Myc.
Myc proteins are key regulators of mammalian cell proliferation. They are transcription factors that activate genes as part of a heterodimeric complex with the protein Max. This review summarizes recent progress in understanding how Myc stimulates cell proliferation and how this might contribute to cellular transformation and tumorigenesis.
Bouchard
C
C
Institute for Molecular Biology and Tumour Research, University of Marburg, Germany. bouchard@imt.uni-marburg.de
Staller
P
P
Eilers
M
M
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D016271:Proto-Oncogene Proteins c-myc / Q000502:physiology*; D014158:Transcription, Genetic / Q000187:drug effects
D006133:Growth Substances; D016271:Proto-Oncogene Proteins c-myc