Torsemide inhibits aldosterone secretion in vitro.
Torsemide inhibited aldosterone secretion by adrenal cells from rats, cows, and guinea pigs stimulated in vitro by potassium, angiotensin, dibutyryl cyclic AMP, ACTH, or corticosterone. Inhibitory concentrations for adrenal cells (micromolar) were comparable with those reported to inhibit ion transport in isolated renal tubules. Inhibition of aldosterone secretion could reduce kaliuresis, and that may explain why torsemide causes less kaliuresis than other diuretics.
William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin 53705, USA. tgoodfri@facstaff.wisc.edu
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D000450:Aldosterone / Q000378:metabolism*; D000818:Animals; D002417:Cattle; D004232:Diuretics / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005665:Furosemide / Q000494:pharmacology; D006168:Guinea Pigs; D051381:Rats; D013449:Sulfonamides / Q000494:pharmacology*; D000077786:Torsemide; D015384:Zona Glomerulosa / Q000187:drug effects* / Q000378:metabolism
D004232:Diuretics; D013449:Sulfonamides; D000450:Aldosterone; D005665:Furosemide; D000077786:Torsemide