RAP, a novel type of ER chaperone.
Members of the low-density lipoprotein (LDL) receptor gene family play an important role in cellular uptake of various extracellular ligands. Recent studies have shown that a 39-kDa protein known as RAP (receptor-associated protein) serves as a molecular chaperone to assist the folding of certain LDL-receptor family proteins and their passage through the secretory pathway. In this review, the authors discuss our current understanding of the roles of RAP as a molecular chaperone/escort protein and present a model of how RAP might carry out these functions.
Dept of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA.
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D002352:Carrier Proteins / Q000502:physiology*; D004721:Endoplasmic Reticulum / Q000737:chemistry* / Q000502:physiology; D005057:Eukaryotic Cells / Q000737:chemistry / Q000502:physiology; D006023:Glycoproteins / Q000502:physiology*; D006801:Humans; D026563:LDL-Receptor Related Protein-Associated Protein; D018832:Molecular Chaperones / Q000502:physiology*; D011973:Receptors, LDL / Q000502:physiology
D002352:Carrier Proteins; D006023:Glycoproteins; D026563:LDL-Receptor Related Protein-Associated Protein; D018832:Molecular Chaperones; D011973:Receptors, LDL