The extracellular matrix in balloon arterial injury: a novel target for restenosis prevention.
The role of the extracellular matrix (ECM) in the pathobiology of restenosis has not been fully appreciated. Recent discoveries have shown the ECM to be a complex, heterogeneous structure whose components are dynamically altered in response to vascular injury. This report reviews the structure and function of vascular ECM and the importance of the matrix in modulating the vascular response to arterial injury such as balloon angioplasty and atherosclerosis.
Division of Cardiology, Duke University Medical Center, Durham, NC 27710, USA.
W B
WB
Batchelor
R
R
Robinson
B H
BH
Strauss
D000800:Angioplasty, Balloon / Q000009:adverse effects*; D000818:Animals; D003327:Coronary Disease / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D003331:Coronary Vessels / Q000293:injuries* / Q000503:physiopathology; D005109:Extracellular Matrix / Q000502:physiology*; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D006801:Humans; D055502:Secondary Prevention
D016326:Extracellular Matrix Proteins