Resistance of aryl-substituted phenylalanines to decarboxylation in the rat.
1. The in vivo decarboxylation of analogues of DL-phenylalanine with methoxy, ethoxy or methylenedioxy substituents on the aromatic nucleus was assessed in the rat by measuring urinary excretion of the corresponding phenylacetic acids and beta-phenylethylamines. Only trace amounts of these amines and acids were excreted. 2. o-Tyrosine was readily decarboxylated, a property that may be attributed to the position and nature of the substituent on the aromatic nucleus. 3. Some phenylpyruvic acids derived from these amino acids exhibited a certain degree of decarboxylation to phenylacetic acids or reduction to phenyllactic acids in the rat.
Department of Chemical Pathology, Queen Charlotte's and Chelsea Hospital, London, United Kingdom.
B L
BL
Goodwin
C R
CR
Ruthven
M
M
Sandler
D000818:Animals; D003653:Decarboxylation; D005260:Female; D010084:Oxidation-Reduction; D010627:Phenethylamines / Q000652:urine*; D010649:Phenylalanine / Q000031:analogs & derivatives / Q000378:metabolism* / Q000652:urine; D010667:Phenylpyruvic Acids / Q000652:urine*; D051381:Rats; D017208:Rats, Wistar; D014443:Tyrosine / Q000031:analogs & derivatives / Q000378:metabolism
D010627:Phenethylamines; D010667:Phenylpyruvic Acids; C029261:phenethylamine; D014443:Tyrosine; D010649:Phenylalanine