Influence of 2-bromopropane on reproductive system--2-bromopropane inhibits forced ovulation in mice.
The influence of 2-bromopropane, an alternative to freon, on ovulation was examined using superovulation induced by pregnant mare's serum gonadotropin and human chorionic gonadotropin (PMSG-hCG) treatment. Three groups of mice were injected intraperitoneally 8 times with 2-bromopropane (2-BP) at 500, 1,000 or 2,000 mg/kg and were induced to ovulate by PMSG-hCG treatment. Injection of 2-BP caused the number of ovulated ova in the 1,000 mg/kg and 2,000 mg/kg groups to decrease remarkably. Uterus weight was also decreased in the 2,000 mg/kg group on the terminal day of the experiment. This result was consistent with cases of human intoxication in which reproductive toxicity was observed.
National Institute of Industrial Health, Kawasaki, Japan.
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Sekiguchi
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Honma
D000818:Animals; D005260:Female; D006842:Hydrocarbons, Brominated / Q000633:toxicity*; D007274:Injections, Intraperitoneal; D051379:Mice; D008813:Mice, Inbred ICR; D009929:Organ Size; D010060:Ovulation / Q000187:drug effects*; D010062:Ovulation Induction
D006842:Hydrocarbons, Brominated; C000493:2-bromopentane