Neonatal noradrenaline depletion prevents the transition of Bergmann glia in the developing cerebellum.
The influence of neonatal administration of 6-hydroxydopamine (6-OHDA) on the cell proliferation in cerebellum was studied using 10-30 days-old rats. Compared to their littermates, treated rats had poor ability in searching, skills performance and orienting in the new environment. Elimination of noradrenergic terminals by 6-OHDA led to a delay in granular cell migration. The secondary foliation in neo-cerebellum was absent. The Bergmann glial cells were abnormally located, structurally different and did not form the intimate association with Purkinje cells. Our findings indicate that without noradrenergic influence neurones and glial cells do not proliferate normally and noradrenaline may act as an important trophic factor also for Bergmann glial cells.
Laboratory of Neurobiology, Medical School, University of Tampere, Finland.
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Podkletnova
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Alho
D000818:Animals; D001522:Behavior, Animal; D002455:Cell Division; D002531:Cerebellum / Q000166:cytology / Q000254:growth & development*; D005260:Female; D007091:Image Processing, Computer-Assisted; D007858:Learning; D008297:Male; D008854:Microscopy, Electron; D009457:Neuroglia / Q000166:cytology*; D009638:Norepinephrine / Q000502:physiology*; D016627:Oxidopamine; D051381:Rats; D017207:Rats, Sprague-Dawley; D013563:Sympathectomy, Chemical
D016627:Oxidopamine; D009638:Norepinephrine