Chromatin boundaries: punctuating the genome.
Transcriptional enhancers are constrained to act within domains defined by boundary elements. How these elements work is a mystery. A recent study emphasizes their autonomous activity; another emphasizes their dependence on nuclear organization. Both effects need to be accounted for by any successful model.
Kellum
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Department of Biology, McGill University, Montreal, Quebec, Canada.
Elgin
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SC
D000818:Animals; D002843:Chromatin; D004742:Enhancer Elements, Genetic; D016678:Genome; D008957:Models, Genetic; D011401:Promoter Regions, Genetic; D012045:Regulatory Sequences, Nucleic Acid
D002843:Chromatin