High value of the radiobiological parameter Dq correlates to expression of the transforming growth factor beta type II receptor in a panel of small cell lung cancer cell lines.
Our panel of SCLC cell lines have previously been examined for their radiobiological characteristics and sensitivity to treatment with TGF beta 1. In this study we examined the possible correlations between radiobiological parameters and the expression of the TGF beta type II receptor (TGF beta-rII). We have, in other studies, shown that the presence of TGF beta-rII was mandatory for transmitting the growth inhibitory effect of TGF beta. The results showed a statistically significant difference in Dq, i.e. the shoulder width of the survival curve, between cell lines expressing TGF beta-rII and cell lines which did not express the receptor (P = 0.01). Cell lines expressing TGF beta-rII had a high Dq-value. TGF beta-rII expression did not correlate with any other radiobiological parameters. We suggest that an intact growth inhibitory pathway mediated by the TGF beta-rII may have a significant role for the repair of radiation induced DNA damage in SCLC.
Section for Radiation Biology, Finsen Center, University Hospital Copenhagen, Denmark.
S
S
Hougaard
M
M
Krarup
P
P
Nørgaard
L
L
Damstrup
M
M
Spang-Thomsen
H S
HS
Poulsen
D015152:Blotting, Northern; D018288:Carcinoma, Small Cell / Q000378:metabolism* / Q000532:radiotherapy; D002470:Cell Survival; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism* / Q000532:radiotherapy; D011836:Radiation Tolerance; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism*; D012044:Regression Analysis; D014407:Tumor Cells, Cultured / Q000528:radiation effects
D018125:Receptors, Transforming Growth Factor beta