Langerhans cell histiocytosis.
The authors present a rare case of Langerhans cell histiocytosis in a 31 year old female patient with vulvar, peri-anal and oral lesions, diabetes insipidus, pulmonary skin and bone infiltrations. Skin biopsy immunohistochemistry presented positive S100 protein and vimentin, but the diagnosis was done with the demonstration of Birbeck granules with electronic microscopy. The treatment was based on systematical chemotherapy although vulvar lesion has a bad response to chemotherapy.
Chauffaille
M de L
Mde L
Disciplina de Hematologia e Hemoterapia, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brazil.
Valério
R M
RM
Diniz
C M
CM
Simões
M M
MM
Enokihara
S
S
Michalany
N
N
Ferreira
K V
KV
Martinez
J A
JA
Hassun
K M
KM
Atallah
A N
AN
Kerbauy
J
J
D000328:Adult; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D003919:Diabetes Insipidus / Q000150:complications; D005260:Female; D005831:Genital Diseases, Female / Q000473:pathology*; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications / Q000473:pathology*; D006801:Humans; D007801:Langerhans Cells / Q000648:ultrastructure; D009418:S100 Proteins / Q000032:analysis; D014746:Vimentin / Q000032:analysis
D009418:S100 Proteins; D014746:Vimentin