Influence of vitamin E acetate on stratum corneum hydration.
The influence of vitamin E (tocopherol, CAS 10191-41-0) on stratum corneum hydration was tested in O/W and W/O emulsions. Additionally, the O/W emulsion was used in an in vivo/in vitro method to gravimetrically obtain evidence concerning the water-binding capacity of the stratum corneum. In the W/O emulsion, 2.5%, 5%, and 7.5% vitamin E were compared. With both types of emulsions, vitamin E increased the stratum corneum hydration statistically significantly (p = 0.0002). In addition, we could provide evidence of an enhanced water-binding capacity after treatment with vitamin E (p = 0.05). For the hydrating effect of vitamin E. its concentration is of importance. The optimum concentration turned out to be 5%.
Dermatological Clinic, Karlsruhe Municipal Hospital Complex, Germany.
W
W
Gehring
J
J
Fluhr
M
M
Gloor
D000293:Adolescent; D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D004655:Emulsions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D024505:Tocopherols; D014810:Vitamin E / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D014867:Water / Q000378:metabolism; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D000975:Antioxidants; D004655:Emulsions; D014867:Water; D014810:Vitamin E; D024502:alpha-Tocopherol; D024505:Tocopherols