Monozygotic twins discordant for single umbilical artery and congenital heart disease.
We report a case of monozygotic twins. One twin had a single umbilical artery and the other co-twin had congenital heart disease. This case and a review of the literature suggest that local environmental factors are important in the pathogenesis of these malformations although genetic factors cannot be excluded.
Department of Obstetrics and Gynecology, Nagasaki University, School of Medicine, Japan.
D
D
Nakayama
H
H
Masuzaki
S
S
Yoshimura
S
S
Moriyama
T
T
Ishimaru
D000328:Adult; D004200:Diseases in Twins / Q000235:genetics*; D004782:Environmental Health; D005260:Female; D006330:Heart Defects, Congenital / Q000235:genetics*; D006801:Humans; D014430:Twins, Monozygotic / Q000235:genetics*; D014469:Umbilical Arteries / Q000002:abnormalities*