Enhanced follicular dendritic cell-B cell interaction in HIV and SIV infections and its potential role in polyclonal B cell activation.
Human immunodeficiency virus (HIV) infections have been characterized by both polyclonal B-cell activation and enhanced responsiveness to B-cell growth factors on one hand and the loss of specific antibody (Ab) responses and refractoriness to the normal signals for B-cell activation on the other. Histopathological studies of lymph node from HIV- and simian immunodeficiency virus (SIV)-infected individuals have indicated initial follicular hyperplasia and the appearance of large irregular germinal centers that undergo progressive involution concomitant with follicular dendritic-cell (FDC) disruption. During this process, follicular dendritic-cell-enriched lymph-node-cell cultures exhibit increased ability to induce cluster formation ("in vitro germinal centers"), lymphocyte proliferation and antibody production compared to uninfected controls. This paper discusses how enhanced FDC-B-cell interaction within SIV-infected germinal centers may result in a reduced ability to select high-affinity B cells and alter the dynamics of antibody-producing-cell and memory-cell generation resulting in the observed hyperactivity.
TherImmune Inc., Rockville, Maryland 20852, USA.
Y J
YJ
Rosenberg
M G
MG
Lewis
M H
MH
Kosco-Vilbois
D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology*; D015815:Cell Adhesion Molecules / Q000096:biosynthesis; D002450:Cell Communication; D002478:Cells, Cultured; D003713:Dendritic Cells / Q000502:physiology*; D015699:HIV Envelope Protein gp120 / Q000502:physiology; D015658:HIV Infections / Q000276:immunology*; D008213:Lymphocyte Activation; D008251:Macaca; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology*; D013601:T-Lymphocytes / Q000502:physiology
D015815:Cell Adhesion Molecules; D015699:HIV Envelope Protein gp120