Differential behavioral effects of angiotensin II microinjected unilaterally into the CA1 hippocampal area.
The behavioral responses of rats to unilateral microinjections of angiotensin II (ATII) into the left or right CA1 hippocampal area were studied. Unilateral (left or right) injections of ATII at a dose of 0.5 microg decreased locomotor activity but, at a dose of 1.0 microg, ATII increased it compared to the respective controls. The effect was more pronounced when ATII was microinjected into the left CAI hippocampal area. The elevated plus-maze experiments showed that ATII microinjections into the right CA1 hippocampal area at a dose of 0.5 microg decreased the ratio of the number of entries into the open arms to the total number of entries (into the open and closed arms). These findings suggest some asymmetric effects of ATII, depending on the dose, the behavioral test and the microinjected hemisphere.
Laboratory of Experimental Psychopharmacology, Institute of Physiology, Bulgarian Academy of Sciences, Sofia. irenata@iph.bio.acad.bg
I
I
Belcheva
M
M
Chobanova
V
V
Georgiev
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008845:Microinjections; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D000804:Angiotensin II