A phylogenetic analysis of the cytochrome b and cytochrome c oxidase I genes supports an origin of mitochondria from within the Rickettsiaceae.
We have cloned and sequenced the genes encoding cytochrome b (cob) and cytochrome c oxidase subunit I (cox1) from Rickettsia prowazekii, a member of the alpha-proteobacteria. The phylogenetic analysis supports the hypothesis that mitochondria are derived from the alpha-proteobacteria and more specifically from within the Rickettsiaceae. We have estimated that the common ancestor of mitochondria and Rickettsiaceae dates back to more than 1500 million years ago.
Sicheritz-Pontén
T
T
Department of Molecular Biology, Uppsala University, Sweden.
Kurland
C G
CG
Andersson
S G
SG
D000596:Amino Acids; D001482:Base Composition; D003001:Cloning, Molecular; D003573:Cytochrome b Group / Q000235:genetics*; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D003576:Electron Transport Complex IV / Q000235:genetics*; D005798:Genes, Bacterial / Q000235:genetics; D008928:Mitochondria / Q000201:enzymology / Q000235:genetics*; D008969:Molecular Sequence Data; D010802:Phylogeny; D012283:Rickettsia prowazekii / Q000201:enzymology / Q000235:genetics; D012287:Rickettsiaceae / Q000201:enzymology / Q000235:genetics*; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA
D000596:Amino Acids; D003573:Cytochrome b Group; D004269:DNA, Bacterial; D003576:Electron Transport Complex IV