Evidence of differential mycobacterial growth and modulation of mycobactericidal property by glucoaminylmuramyl dipeptide in murine macrophages.
These results show that given a source of mouse tissue macrophage, there is differential mycobacterial growth with different species of mycobacteria. This suggests that each species of mycobacteria generates a differential response in a given tissue macrophage within the same host for its survival. For example, BCG-P growth becomes permissive in the presence of GMDP in splenic and peritoneal macrophages. Whereas in the same tissue M. tuberculosis growth becomes non-permissive. From Table 2 it is evident that inhibition of inflammatory responses following M. tuberculosis infection leads to reduction of viable organisms in murine macrophages.
Medical Research Council, Tuberculosis and Related Infections Unit, Hammersmith Hospital, London, United Kingdom. nvenkata@rpms.ac.uk
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Venkataprasad
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D002448:Cell Adhesion; D002460:Cell Line; D002478:Cells, Cultured; D005260:Female; D007700:Kinetics; D008264:Macrophages / Q000187:drug effects / Q000382:microbiology / Q000502:physiology*; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000382:microbiology / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009169:Mycobacterium tuberculosis / Q000254:growth & development; D010587:Phagocytosis; D013045:Species Specificity; D013154:Spleen / Q000502:physiology; D013481:Superoxides / Q000378:metabolism
D000276:Adjuvants, Immunologic; D013481:Superoxides; D000119:Acetylmuramyl-Alanyl-Isoglutamine; C063429:glucosaminylmuramyl-2-alanine-D-isoglutamine