Elevated levels of interleukin-6 may occur in cerebrospinal fluid from patients with recent epileptic seizures.
Experimental animal studies suggest the involvement of cytokines in epilepsy. We measured increased concentrations of interleukin-6 in four out of 15 cerebrospinal fluid samples from unmedicated patients with newly developed tonic-clonic seizures; plasma levels were also increased but to a lesser extent. Although the significance of cytokine production in relation to epileptic seizures is not known, it might be important for neuronal survival.
Department of Neurology, Tampere University Hospital, Finland.
J
J
Peltola
M
M
Hurme
A
A
Miettinen
T
T
Keränen
D000293:Adolescent; D000328:Adult; D002097:C-Reactive Protein / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D012640:Seizures / Q000134:cerebrospinal fluid*; D013997:Time Factors
D015850:Interleukin-6; D002097:C-Reactive Protein