Effect of sulphur mustard inhalation exposure on some urinary variables in mice.
The effect of sulphur mustard (2,2'-dichlorodiethyl sulphide) exposure through inhalation at 0.5. 1.0 and 2.0 LC50 (21.2, 42.3 and 84.6 mg m(-3) for 1 h) on some urinary variables was studied in female mice at 6, 24 and 48 h and 7 days post-exposure. The urinary excretion and circulatory blood accumulation of uric acid increased significantly. The level of creatine was also elevated significantly as compared to the control at 2 LC50. It is concluded that sulphur mustard alkylates DNA and triggers catabolism of apurinated purine bases in a very short time. The increase in uric acid excretion in urine can be detected only when the exposure concentration is high.
Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior, India.
O
O
Kumar
R
R
Vijayaraghavan
D000280:Administration, Inhalation; D000818:Animals; D002273:Carcinogens / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D002619:Chemical Warfare Agents / Q000378:metabolism / Q000633:toxicity*; D003401:Creatine / Q000652:urine; D003404:Creatinine / Q000652:urine; D005260:Female; D051379:Mice; D009151:Mustard Gas / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D011687:Purines / Q000378:metabolism; D014527:Uric Acid / Q000097:blood / Q000652:urine*
D002273:Carcinogens; D002619:Chemical Warfare Agents; D011687:Purines; D014527:Uric Acid; D003404:Creatinine; D003401:Creatine; D009151:Mustard Gas