[Structural-functional changes in the thyroid gland after chronic exposure to the dioxin-containing herbicide 2,4-D].
White rats were given by lavage 40% solution of the herbicide 2,4-D (as an amine salt) in doses 1.0 and 0.5 mg/kg during 3 months. Destructive changes in follicles, lymphohistiocytic infiltrates, areas with morphological signs of activation (predominance of small follicles), high alkaline phosphatase and glycoproteins activity in thyrocytes were revealed.
Malysheva
L N
LN
Research Institute of Human Morphology, Moscow.
Zhavoronkov
A A
AA
D015084:2,4-Dichlorophenoxyacetic Acid / Q000737:chemistry / Q000506:poisoning*; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D004147:Dioxins / Q000032:analysis*; D006023:Glycoproteins / Q000378:metabolism; D006540:Herbicides / Q000737:chemistry / Q000506:poisoning*; D008297:Male; D051381:Rats; D013961:Thyroid Gland / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D013997:Time Factors
D004147:Dioxins; D006023:Glycoproteins; D006540:Herbicides; D015084:2,4-Dichlorophenoxyacetic Acid; D000469:Alkaline Phosphatase