Recovery of retching after lesions involving the nucleus of the solitary tract.
The nucleus of the solitary tract (NTS) in the caudal brainstem receives various inputs that trigger vomiting. Chemical (kainic acid) NTS lesions in decerebrate, paralyzed cats temporarily suppressed fictive vomiting induced by different emetics. Subsequently, retching but not expulsion, resumed in 2-3.5 h. Since the NTS does not appear essential for retching, antiemetic drugs targeted at the NTS may not completely suppress vomiting.
The Rockefeller University, New York, New York 10021, USA.
A D
AD
Miller
T
T
Umezaki
K
K
Nakazawa
K
K
Shiba
M S
MS
Siniaia
Y
Y
Zheng
D000818:Animals; D002415:Cats; D005260:Female; D007276:Injections, Intraventricular; D007608:Kainic Acid / Q000494:pharmacology; D008297:Male; D017552:Solitary Nucleus / Q000187:drug effects / Q000502:physiology*; D014839:Vomiting / Q000209:etiology / Q000503:physiopathology*
D007608:Kainic Acid