Coexistence of Fabry's disease and systemic lupus erythematosus.
This report describes a case of a female with systemic lupus erythematosus, who was subsequently diagnosed with Fabry's disease. Due to similarities in the organs involved by these two multisystem disorders, difficulties were encountered in establishing a prompt diagnosis of Fabry's disease. That and subsequent management of this patient are discussed. A literature review of the coexistence of the two disorders along with the potential pathogenic mechanisms explaining this association are explored.
Rahman
P
P
University of Toronto Psoriatic Arthritis Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Ontario, Canada.
Gladman
D D
DD
Wither
J
J
Silver
M D
MD
D004699:Endocardium / Q000648:ultrastructure; D000795:Fabry Disease / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006028:Glycosphingolipids / Q000652:urine; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D008247:Lysosomes / Q000378:metabolism / Q000648:ultrastructure; D008875:Middle Aged; D009206:Myocardium / Q000648:ultrastructure; D000519:alpha-Galactosidase / Q000378:metabolism
D006028:Glycosphingolipids; C088880:ceramide trihexoside; D000519:alpha-Galactosidase