[Molecular biology of prostaglandin E receptors--expression of multi-function by PGE receptor subtypes and isoforms].
We reviewed the recent advance in the molecular characterization of prostaglandin E(PGE) receptor. PGE exerts versatile actions in diverse tissues and cells through specific cell surface receptors. PGE receptors(EP) consist of 4 subtypes(EP1, EP2, EP3 and EP4), which differ in the couple of signal transduction. In addition, at least three isoforms of EP3 are produced through alternative RNA splicing from a single gene and differ only in the efficiency of G protein activation and in the specificity of coupling to G proteins. These subtypes and isoforms express and function in specific tissues and cells in various organs, in where they mediate a variety of PGE2-induced physiological responses.
Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University.
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Ichikawa
D000818:Animals; D004064:Digestive System / Q000378:metabolism; D005260:Female; D019204:GTP-Binding Proteins / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D011485:Protein Binding; D018078:Receptors, Prostaglandin E / Q000145:classification / Q000502:physiology; D015398:Signal Transduction; D014599:Uterus / Q000378:metabolism
D018078:Receptors, Prostaglandin E; D019204:GTP-Binding Proteins