Isolation and chemoantibiotic resistance of Ureaplasma urealyticum in HIV-1 infected patients.
The presence of Ureaplasma urealyticum was evaluated on 1912 vaginal and urethral swabs from HIV-1 seronegative (HIV-) inpatients (210) and outpatients (503) suffering from acute urethritis or vaginitis; asymptomatic HIV- outpatients (201); and asymptomatic HIV-1 seropositive (HIV+) inpatients (120). The study reported an increased frequency of Ureaplasma urealyticum isolates in asymptomatic HIV+ compared to asymptomatic HIV- subjects. As expected, the frequency of Ureaplasma urealyticum isolates increased in symptomatic HIV- subjects. Strains of Ureaplasma urealyticum resistant to ciprofloxacin, tetracycline and minocycline were more frequently isolated in HIV+ (34.1%) than HIV- (3.8%) subjects; on the other hand, only 1 out of 704 (0.1%) strains isolated from outpatients was resistant to ciprofloxacin. We found no association in HIV+ patients between Ureaplasma urealyticum infection and CD4 count or HIV-1 p24 antigenemia.
Institute of Microbiology, University of Brescia, Spedali Civili, Italy.
F
F
Martinelli
A
A
Caruso
S
S
Ausenda
M
M
Corulli
S
S
Licenziati
E
E
Garrafa
A
A
Turano
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000382:microbiology; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology; D002939:Ciprofloxacin / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D005260:Female; D015658:HIV Infections / Q000382:microbiology* / Q000821:virology; D015497:HIV-1; D006801:Humans; D008297:Male; D008911:Minocycline / Q000494:pharmacology; D013752:Tetracycline / Q000494:pharmacology; D016990:Ureaplasma urealyticum / Q000187:drug effects / Q000302:isolation & purification*; D014521:Urethra / Q000382:microbiology*; D014621:Vagina / Q000382:microbiology*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D002939:Ciprofloxacin; D013752:Tetracycline; D008911:Minocycline