Immune Responses: costimulatory receptors have their say.
Lymphocytes are more likely to make an immune response if costimulatory and antigen receptors coincidently signal; the way the signals are integrated illustrates how a lymphocyte learns to distinguish self from foreign antigens, and provides a model for coincident signaling through more than one receptor.
Medical Genome Centre The John Curtin School of Medical Research Australian National University Canberra, ACT 2601, Australia. Benny.Weintraub@anu.edu.au
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D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D000941:Antigens / Q000276:immunology*; D018941:Antigens, CD19 / Q000502:physiology; D001402:B-Lymphocytes / Q000276:immunology*; D018821:CD18 Antigens / Q000502:physiology; D006801:Humans; D007108:Immune Tolerance; D018448:Models, Immunological; D011947:Receptors, Antigen, B-Cell / Q000276:immunology*; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology*
D000941:Antigens; D018941:Antigens, CD19; D018821:CD18 Antigens; D011947:Receptors, Antigen, B-Cell; D011948:Receptors, Antigen, T-Cell