In vivo gene therapy with a cationic polymer markedly enhances the antitumor activity of antiangiogenic genes.
A cationic polymer, Superfect, when complexed to the therapeutic genes, p53 and a TSP fragment, displays a much greater antitumor activity compared to cationic liposomes. At the dosages used, this polymer did not demonstrate any nonspecific antitumor effects in contrast to the liposome carriers. These in vivo findings should further stimulate the development of carrier polymers as well as expedite the evaluation of several antiangiogenic genes.
Xu
M
M
Department of Pathology, University of Maryland at Baltimore, Building MSTF, Room 759, Baltimore, Maryland 21201, USA.
Chen
Q R
QR
Kumar
D
D
Stass
S A
SA
Mixson
A J
AJ
D000818:Animals; D002412:Cations; D005260:Female; D018014:Gene Transfer Techniques; D016158:Genes, p53; D015316:Genetic Therapy / Q000379:methods*; D008081:Liposomes; D008325:Mammary Neoplasms, Experimental / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D051379:Mice; D009389:Neovascularization, Pathologic; D011108:Polymers; D019699:Thrombospondins / Q000235:genetics*; D014162:Transfection; D014407:Tumor Cells, Cultured
D002412:Cations; D008081:Liposomes; D011108:Polymers; D019699:Thrombospondins