Myelodysplastic syndrome with B cell clonality in a patient five years after renal transplantation.
A female patient received a renal transplantation from an unrelated cadaver donor, and five years later developed myelodysplastic syndrome (MDS) with immunological abnormalities. Chromosomal analysis showed trisomy 8 in bone marrow cells. FISH analysis indicated that trisomy 8 was present in 4% of CD19 + cells, suggesting that the MDS clone involved B lymphocytes. Polymerase chain reaction of the human androgen receptor gene indicated B cell clonality (54%) and granulocyte clonality (63%). There have been no previous reports of secondary MDS following renal transplantation in which the MDS clone involved the B cell lineage. The abnormal MDS B cell clone may have caused the immunological abnormalities.
Second Department of Internal Medicine, Hyogo College of Medicine, Japan.
T
T
Okamoto
M
M
Okada
T
T
Itoh
A
A
Mori
K
K
Saheki
H
H
Takatsuka
H
H
Wada
A
A
Tamura
Y
Y
Fujimori
Y
Y
Takemoto
A
A
Kanamaru
E
E
Kakishita
D001402:B-Lymphocytes / Q000473:pathology*; D002454:Cell Differentiation; D002908:Chronic Disease; D005260:Female; D005921:Glomerulonephritis / Q000628:therapy*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000209:etiology* / Q000276:immunology* / Q000473:pathology; D013997:Time Factors