Novel HLA-A and HLA-B alleles.
Nine novel HLA-A and HLA-B alleles are described: A*2609, A*6803, A*6806, B*1539, B*1540, B*2712, B*4103, B*5109, and B*5603. Most appear to have arisen by gene conversion events. B*5603 appears to have arisen by a reciprocal recombination event joining exon 2 of a B*55/ *56 allele with exon 3 of a B*15 allele. Serologically, the antigen encoded by this allele types with broad B22- and Bw6-specific alloantisera. Also unique, the antigen encoded by B*2712 does not react with B27-specific alloantisera but does react with Bw6-specific alloantisera.
Department of Microbiology and Immunology, Georgetown University Medical School, Washington, DC, USA.
C K
CK
Hurley
N
N
Steiner
C
C
Kosman
W
W
Mitton
R
R
Koester
M
M
Bei
J
J
Bush
J
J
McCormack
A
A
Hahn
V
V
Henson
R
R
Hoyer
J A
JA
Wade
R J
RJ
Hartzman
J
J
Ng
D000483:Alleles; D000595:Amino Acid Sequence; D001483:Base Sequence; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data
D015234:HLA-A Antigens; D015235:HLA-B Antigens