Follow-up of children after fetal treatment for obstructive uropathy.
BACKGROUND
Improvement in the ability to evaluate fetuses with obstructive uropathy, combined with technologic advances, has allowed successful fetal treatment of these conditions in Japan. We analyzed the prenatal and postnatal clinical courses of patients who underwent shunt placement in utero.


METHODS
We treated 6 patients who underwent fetal intervention and were transferred to us for urologic management. Gestational age at detection of abnormalities ranged from 11 weeks to 31 weeks, and fetal intervention was done between 16 weeks and 32 weeks. Excluding 1 infant who was delivered 6 days after the intervention, the mean period between shunt placement and delivery was 17 weeks.


RESULTS
Urologic pathology included prune belly syndrome with urethral hypoplasia in 3 patients, cloacal anomaly in 1, posterior urethral valves in 1, and pelviureteric junction stenosis of a solitary kidney in 1. Four patients required ventilation support in the neonatal period, and 2 of them suffered frequent infections during follow-up. Five patients who underwent vesico-amniotic shunt placement continue to require clean intermittent catheterizations via vesicostomy because of hypoactive detrusors and hypoplastic urethras. After urologic treatment, serum creatinine in 5 patients reached a minimum of less than 0.4 mg/dL at some time during the first year of life. Another patient with a minimum creatinine level of 1.0 mg/dL has moderate renal insufficiency.


CONCLUSIONS
From our series, it appears that early (before 20 weeks of gestation) shunt placement in severe lower urinary tract obstruction may benefit renal and pulmonary function. However, its efficacy in regard to bladder function remains questionable: shunt placement does not permit regular storage and evacuation, which may be essential for functional bladder development.
Division of Urology, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Japan.
K
K
Shimada
S
S
Hosokawa
A
A
Tohda
F
F
Matsumoto
M
M
Suzuki
Y
Y
Morimoto
D005260:Female; D005315:Fetal Diseases / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D006869:Hydronephrosis / Q000151:congenital / Q000175:diagnosis / Q000601:surgery*; D007231:Infant, Newborn; D007677:Kidney Function Tests; D008297:Male; D011296:Prenatal Diagnosis; D012121:Respiration, Artificial; D012189:Retrospective Studies; D014521:Urethra / Q000002:abnormalities / Q000601:surgery; D014524:Urethral Obstruction / Q000601:surgery*; D001743:Urinary Bladder / Q000502:physiology