"Insects do not have sex hormones": a myth?
Mammals have two genes (SRY and DMT1) for testis formation-androgenesis, an anti-testis gene, DAX1, an anti-Müllerian duct hormone, and steroid sex hormones. Drosophila uses the sex-lethal, transformer, and doublesex genes for sexual differentation and is supposed to lack sex hormones. However, the statement that insects do not have sex hormones loses much of its credibility if one considers (1) the classical endocrinological work on sexual differentiation in the firefly Lampyris and in the hevea tussock moth Orgyia; (2) the recent identification of an androgenic hormone and its role in sex determination in the isopod Armadillidium; (3) the similarity between steroidogenic factor 1 (SF-1) of mammals and fushi tarazu factor 1 (FTZ-F1) of Drosophila; and (4) the steroidogenic effect of gonadotropins secreted by the brain of female locusts and mosquitoes and of male gypsy moth. In our model, based on data from the literature, ecdysone, when present in high concentrations, might function as an androgenic sex steroid. It is also the precursor of 20-OH-ecdysone, which is the moulting hormone of insects, and in vitellogenic females of many species, the counterpart of estrogens as well. Other gender-specific hormones are likely to exist in the brain-gonad axis.
Zoological Institute, Katholieke Universiteit Leuven, Leuven, Belgium. arnold.deloof@bio.kuleuven.ac.be
A
A
De Loof
R
R
Huybrechts
D000595:Amino Acid Sequence; D000818:Animals; D001181:Arthropods / Q000502:physiology*; D026461:Ecdysteroids; D005260:Female; D012739:Gonadal Steroid Hormones / Q000235:genetics*; D007301:Insect Hormones / Q000235:genetics*; D008297:Male; D008322:Mammals / Q000502:physiology; D008969:Molecular Sequence Data; D012733:Sex Differentiation / Q000502:physiology*; D013045:Species Specificity; D013256:Steroids / Q000502:physiology
D026461:Ecdysteroids; D012739:Gonadal Steroid Hormones; D007301:Insect Hormones; D013256:Steroids