UK-3A, a novel antifungal antibiotic from Streptomyces sp. 517-02: fermentation, isolation, structural elucidation and biological properties.
A novel antifungal antibiotic, UK-3A, was obtained from the mycelial cake of Streptomyces sp. 517-02. UK-3A was very similar in structure to UK-2A, a structural relative of antimycin A. The antifungal spectrum of UK-3A was relatively broad (MICs for yeasts and filamentous fungi: 1.56-6.25 and 0.39-1.56 micrograms/ml, respectively). The cytotoxic activity of UK-3A was weak (IC50: 18-100 micrograms/ml).
Ueki
M
M
Faculty of Science, Osaka City University, Japan.
Kusumoto
A
A
Hanafi
M
M
Shibata
K
K
Tanaka
T
T
Taniguchi
M
M
D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D006801:Humans; D066298:In Vitro Techniques; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011725:Pyridines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; D007783:Lactones; D011725:Pyridines; C111142:UK-3A