Temporal effects of an infusion of dobutamine hydrochloride in horses anesthetized with halothane.
OBJECTIVE
To evaluate temporal hemodynamic effects of dobutamine in horses anesthetized with halothane.


METHODS
8 adult Thoroughbreds.


METHODS
Anesthesia was induced by i.v. administration of romifidine and ketamine and maintained using halothane in oxygen. After 60 minutes, dobutamine was administered i.v. for 60 minutes at 4 micrograms/kg of body weight/min. Measurements of left ventricular function were obtained by transesophageal echocardiography and cardiac catheterization.


RESULTS
Mean, systolic, diastolic, aortic, pulmonary arterial, and left and right ventricular end-diastolic and systolic pressures, maximal rate of increase of intraventricular pressure (LVdp/dtmax), maximum acceleration (dv/dtmax) and velocity (Vmax) of aortic blood flow, cardiac output, and left ventricular velocity time integral were significantly increased, whereas left ventricular pre-ejection period and ejection time significantly decreased. Cardiac output, LVdp/dtmax, Vmax, and dv/dtmax increased throughout infusion. Heart rate was significantly less after 10 minutes and significantly greater at 60 minutes than before infusion. Supraventricular tachycardia developed in 2 horses. Cardiac output, LVdp/dtmax, Vmax, dv/dtmax, left ventricular and aortic systolic pressures, and mean aortic pressure had not returned to control values 30 minutes after infusion was discontinued.


CONCLUSIONS
At this dosage, dobutamine did not achieve peak effect on many hemodynamic variables within 40 minutes of commencing infusion, and effects of 60-minute infusion persisted after infusion was discontinued.


CONCLUSIONS
Dobutamine has a hemodynamic profile suited to treatment of low cardiac output in anesthetized horses; however, sustained administration may be associated with supraventricular tachycardia and a protracted time to peak effect.
Young
L E
LE
Department of Veterinary Clinical Studies, Royal (Dick) School of Veterinary Studies, Near Roslin, Midlothian, United Kingdom.
Blissitt
K J
KJ
Clutton
R E
RE
Molony
V
V
D000769:Anesthesia, Inhalation / Q000662:veterinary; D018685:Anesthetics, Inhalation; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D006328:Cardiac Catheterization / Q000662:veterinary; D002302:Cardiac Output / Q000187:drug effects; D003971:Diastole / Q000187:drug effects; D004280:Dobutamine / Q000008:administration & dosage / Q000494:pharmacology*; D017548:Echocardiography, Transesophageal / Q000662:veterinary; D006221:Halothane; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006736:Horses; D007262:Infusions, Intravenous; D013617:Tachycardia, Supraventricular / Q000139:chemically induced; D013997:Time Factors; D016277:Ventricular Function, Left / Q000187:drug effects* / Q000502:physiology
D018685:Anesthetics, Inhalation; D004280:Dobutamine; D006221:Halothane