Antioxidant protection of cerebellar beta-adrenergic receptor function in aged F344 rats.
We examined whether a 2-week treatment with the spin-trapping agent MDL 101.002 (MDL) or a diet supplemented with vitamin E (Vit E) would alleviate age-related deficits in cerebellar noradrenergic function of male 18-20 month old F344 rats compared to age-matched controls. Cerebellar beta-adrenergic receptor function was assessed using extracellular recordings of Purkinje cells during iontophoresis of GABA and isoproterenol (ISO). Noradrenergic receptor function of MDL and Vit E-treated rats was similar to young rats whereas for non-treated rats it was typical of that previously recorded in aged rats. Thus, treatment with MDL or Vit E reverses age-related deficits in cerebellar noradrenergic receptor function.
Institute for Behavioral Genetics, University of Colorado, Boulder 80309, USA.
T J
TJ
Gould
K
K
Chadman
P C
PC
Bickford
D000367:Age Factors; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002531:Cerebellum / Q000378:metabolism*; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D011943:Receptors, Adrenergic, beta / Q000502:physiology*
D000975:Antioxidants; D011943:Receptors, Adrenergic, beta