[Structural-functional changes in the thyroid gland after chronic exposure to the dioxin-containing herbicide 2,4-D].
White rats were given by lavage 40% solution of the herbicide 2,4-D (as an amine salt) in doses 1.0 and 0.5 mg/kg during 3 months. Destructive changes in follicles, lymphohistiocytic infiltrates, areas with morphological signs of activation (predominance of small follicles), high alkaline phosphatase and glycoproteins activity in thyrocytes were revealed.
Research Institute of Human Morphology, Moscow.
L N
LN
Malysheva
A A
AA
Zhavoronkov
D015084:2,4-Dichlorophenoxyacetic Acid / Q000737:chemistry / Q000506:poisoning*; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D004147:Dioxins / Q000032:analysis*; D006023:Glycoproteins / Q000378:metabolism; D006540:Herbicides / Q000737:chemistry / Q000506:poisoning*; D008297:Male; D051381:Rats; D013961:Thyroid Gland / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D013997:Time Factors
D004147:Dioxins; D006023:Glycoproteins; D006540:Herbicides; D015084:2,4-Dichlorophenoxyacetic Acid; D000469:Alkaline Phosphatase