5-HT3 receptors are not involved in conditioned taste aversions induced by 5-hydroxytryptamine, ipecacuanha or cisplatin.
We have used the rat to examine the involvement of the 5-HT3 receptor in the mechanism(s) of conditioned taste aversion induced by 5-hydroxytryptamine (5-HT) and selected emetic drugs. 5-HT, ipecacuanha and cisplatin all induced conditioned taste aversion at doses known to induce emesis in other species but the responses were resistant to treatment with the 5-HT3 receptor antagonists ondansetron and granisetron. Further, m-chlorophenylbiguanide, a selective and potent 5-HT3 receptor agonist, failed to induce a conditioned taste aversion. The data provide strong evidence that the 5-HT3 receptor is not involved in conditioned taste aversion mechanisms in the rat. Results are discussed in terms of the usefulness of the rat conditioned taste aversion paradigm to anti-emetic research.
Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin NT. jar@cuhk.edu.hk
J A
JA
Rudd
M P
MP
Ngan
M K
MK
Wai
D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects; D001362:Avoidance Learning / Q000502:physiology; D002945:Cisplatin / Q000009:adverse effects / Q000494:pharmacology*; D003214:Conditioning, Classical; D004327:Drinking Behavior; D017829:Granisetron / Q000494:pharmacology; D007486:Ipecac / Q000494:pharmacology*; D008297:Male; D017294:Ondansetron / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin / Q000502:physiology*; D044406:Receptors, Serotonin, 5-HT3; D012701:Serotonin / Q000494:pharmacology*; D012702:Serotonin Antagonists / Q000494:pharmacology; D013649:Taste / Q000502:physiology*
D000970:Antineoplastic Agents; D002945:Cisplatin; D017829:Granisetron; D007486:Ipecac; D017294:Ondansetron; D011985:Receptors, Serotonin; D044406:Receptors, Serotonin, 5-HT3; D012701:Serotonin; D012702:Serotonin Antagonists