Pharmaceutical applications of in vivo EPR.
The aim of this article is to discuss the applications of in vivo EPR in the field of pharmacy. In addition to direct detection of free radical metabolites and measurement of oxygen, EPR can be used to characterize the mechanisms of drug release from biodegradable polymers. Unique information about drug concentration, the microenvironment (viscosity, polarity, pH) and biodistribution (by localized measurement or EPR Imaging) can be obtained.
Philipps University Marburg, Department of Pharmaceutics and Biopharmacy, Germany.
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Mäder
D000818:Animals; D055592:Biophysical Phenomena; D001703:Biophysics; D016503:Drug Delivery Systems; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods*; D005609:Free Radicals / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D010599:Pharmacokinetics; D010600:Pharmacology / Q000379:methods*; D013113:Spin Labels
D005609:Free Radicals; D013113:Spin Labels