Pouchitis.
Pouchitis is a major long-term complication of the continent ileostomy as well as the ileoanal pouch anastomosis. When diagnosed on the basis of clinical, endoscopic and histologic features, this syndrome has been demonstrated almost exclusively in patients with ulcerative colitis. The clinical course, the endoscopic findings and the histologic abnormalities resemble those of ulcerative colitis. The association with extra-intestinal manifestations further supports the hypothesis that pouchitis represents ulcerative colitis in the small bowel. All ileal reservoirs show bacterial overgrowth, especially of anaerobes. As a response to this altered intraluminal environment chronic inflammation and incomplete colonic metaplasia occur. The efficiency of metronidazole does suggest that bacteriological factors play an important role in the pathogenesis of pouchitis.
Department of Surgery, University Hospital Dijkzigt, Rotterdam, The Netherlands.
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Schouten
D001647:Bile Acids and Salts / Q000378:metabolism; D003093:Colitis, Ulcerative / Q000209:etiology; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D015994:Incidence; D007511:Ischemia / Q000150:complications; D019449:Pouchitis / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy
D001647:Bile Acids and Salts; D005227:Fatty Acids