Modulation by IL-10 of antigen-induced allergic responses in mice.
Over the last few years, we examined the anti-allergic properties of interleukin (IL)-10 in different models of inflammation in the mouse, as well as against IgE-dependent activation of mouse bone marrow-derived mast cells (BMMC). We showed that IL-10, concurrently administered with ovalbumin, inhibited inflammatory cell accumulation in the airways and in the peritoneal cavity of sensitized mice, as well as the accompanying cytokine release. IL-10 also blocked antigen-induced cytokine generation by IgE-stimulated BMMC. Together, these results identify a novel biological property of IL-10, as a cytokine with potent anti-allergic activities.
Unité de Pharmacologie Cellulaire, Institut Pasteur, INSERM n degrees 485, Paris, France.
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C
Zuany-Amorim
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Vargaftig
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Pretolani
D000818:Animals; D015496:CD4-Positive T-Lymphocytes; D016207:Cytokines / Q000502:physiology; D007073:Immunoglobulin E; D066298:In Vitro Techniques; D016753:Interleukin-10 / Q000627:therapeutic use*; D015848:Interleukin-5; D008407:Mast Cells; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000494:pharmacology; D010529:Peritoneal Cavity; D012130:Respiratory Hypersensitivity / Q000188:drug therapy*; D014409:Tumor Necrosis Factor-alpha
D016207:Cytokines; D015848:Interleukin-5; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D007073:Immunoglobulin E; D010047:Ovalbumin