Tetracycline and its analogues: a therapeutic paradigm in periodontal diseases.
This article discusses the use of tetracyclines in the clinical management of periodontal infections. A review of the drugs pharmacology, pharmacokinetics, and potential adverse effects shows that they are relatively safe if used in appropriate dosages and under controlled conditions. Current data suggest that the routine use of tetracyclines in conjunction with the treatment of periodontitis is unnecessary. However, their distinctive characteristics can be utilized in different delivery systems as an adjunctive aid to conventional treatment of juvenile and refractory forms of periodontitis.
Weinberg
M A
MA
Department of Periodontics, New York University College of Dentistry, New York, 10010, USA.
Bral
M
M
D000328:Adult; D010520:Aggressive Periodontitis / Q000188:drug therapy; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D016503:Drug Delivery Systems; D006801:Humans; D010510:Periodontal Diseases / Q000188:drug therapy*; D010518:Periodontitis / Q000188:drug therapy; D013752:Tetracycline / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D013753:Tetracycline Resistance
D000900:Anti-Bacterial Agents; D013752:Tetracycline