Respiratory feedback effects on vaporisers in circle systems.
We studied a group of spontaneously breathing patients anaesthetised for routine orthopaedic surgery using a circle system and isoflurane in a Komesaroff vaporiser within the circle. We observed and recorded: (1) the change in inspired isoflurane concentration caused by changing the fresh gas flow, (2) the increased respiration produced by surgical stimulus and the resulting increase in isoflurane concentration, (3) the respiratory depression produced by opioids and the consequent decrease in isoflurane concentration. We consider this regulation of anaesthetic uptake by the patient to be beneficial.
Department of Anaesthesia, Northwick Park Hospital, Harrow, UK.
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White
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Royston
D000701:Analgesics, Opioid / Q000494:pharmacology; D000764:Anesthesia, Closed-Circuit / Q000295:instrumentation*; D018685:Anesthetics, Inhalation / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005246:Feedback; D006801:Humans; D007530:Isoflurane / Q000008:administration & dosage*; D008614:Meperidine / Q000494:pharmacology; D009330:Nebulizers and Vaporizers; D019637:Orthopedic Procedures; D012119:Respiration / Q000187:drug effects
D000701:Analgesics, Opioid; D018685:Anesthetics, Inhalation; D008614:Meperidine; D007530:Isoflurane