Acute tryptophan depletion attenuates the prolactin response to d-fenfluramine challenge in healthy human subjects.
Prolactin responses to d-fenfluramine (d-FEN) Challenge (0.5 mg/kg PO) were examined after pretreatment with and without acute tryptophan depletion (ATD) in six physically healthy male volunteers. Compared to pretreatment with SHAM-ATD, ATD pretreatment attenuated the PRL response to d-FEN Challenge in all subjects. These data suggest that PRL responses to cl-FEN challenge reflect to a substantial degree the activity of newly synthesized 5-HT.
Department of Psychiatry, MCP Hahnemann School of Medicine, Philadelphia, PA 19129, USA.
E F
EF
Coccaro
R J
RJ
Kavoussi
T B
TB
Cooper
R
R
Hauger
D000328:Adult; D005277:Fenfluramine / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood*; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D014364:Tryptophan / Q000097:blood / Q000172:deficiency*
D005277:Fenfluramine; D011388:Prolactin; D017367:Selective Serotonin Reuptake Inhibitors; D014364:Tryptophan