A pilot study of dehydroepiandrosterone sulfate in myotonic dystrophy.
We studied the effect of i.v. administration of a dehydroepiandrosterone sulfate (DHEAS) preparation (200 mg/day for 8 weeks) in 11 patients with myotonic dystrophy (MyD). After DHEAS, activities of daily living improved, muscle strength increased, and myotonia decreased. Conduction block and premature beats also improved in the four patients with cardiac involvement. This pilot study may provide a rationale for a controlled study of DHEAS in MyD.
First Department of Internal Medicine, Osaka Medical College, Takatsuki-City, Japan.
M
M
Sugino
N
N
Ohsawa
T
T
Ito
S
S
Ishida
H
H
Yamasaki
F
F
Kimura
K
K
Shinoda
D000203:Activities of Daily Living; D000328:Adult; D019314:Dehydroepiandrosterone Sulfate / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009223:Myotonic Dystrophy / Q000188:drug therapy*; D010865:Pilot Projects
D019314:Dehydroepiandrosterone Sulfate