Tumorigenicity and immunogenicity in a murine model of B-cell leukemia/lymphoma (BCL1).
Multiple injections of intact irradiated BCL1 cells, a murine B-cell leukemia/lymphoma can trigger a dose-dependent anti-tumor immune response in naive syngeneic mice. The ability to induce anti-BCL1 immunity and the effect of various cell-modifications on BCL1 tumorigenicity and immunogenicity was evaluated. Newcastle disease virus (NDV) infection or transfer of cytokine genes by both retroviral and Adeno 5 vectors affect neither tumorigenicity nor immunogenicity of BCL1 cells given as a non-immunogenic cell-dose. New ways will have to be developed to elicit a reliable and reproducible anti-tumor effect in spontaneously arising and non-immunogenic hematological malignancies.
The Department of Bone Marrow Transplantation, Hadassah University Hospital, Jerusalem, Israel.
S
S
Morecki
A
A
Nagler
Z
Z
Zakay-Rones
M
M
Schlesinger
A
A
Lubina-Salomon
T
T
Pugatsch
Y
Y
Moshel
S
S
Slavin
D000256:Adenoviridae / Q000254:growth & development; D000818:Animals; D004306:Dose-Response Relationship, Immunologic; D018014:Gene Transfer Techniques; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000235:genetics; D007114:Immunization; D007371:Interferon-gamma / Q000235:genetics; D007376:Interleukin-2 / Q000235:genetics; D015448:Leukemia, B-Cell / Q000276:immunology; D007942:Leukemia, Experimental / Q000235:genetics / Q000276:immunology* / Q000821:virology; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D009522:Newcastle disease virus / Q000254:growth & development; D012190:Retroviridae; D014161:Transduction, Genetic
D007376:Interleukin-2; D007371:Interferon-gamma; D016178:Granulocyte-Macrophage Colony-Stimulating Factor