Scanning electron microscopic findings on intraocular metallic foreign bodies.
BACKGROUND
The study reported here was performed to investigate morphologic intraocular reactions on the surface of metallic intraocular foreign bodies (IOFB) with scanning electron microscopy.


METHODS
Twenty-seven extracted IOFB were investigated. Of these, 22 were situated in the vitreous body; 19 had contact with the retina. Five IOFB had been removed from the anterior segment (control group). The duration of intraocular retention was 6 h to 24 days. Immediately after microsurgical removal the IOFB were fixed, dehydrated, dried, sputter-coated and investigated with a scanning electron microscope. Two IOFB from the vitreous were treated for collagen preservation.


RESULTS
Eighteen of 20 intravitreal IOFB showed fibers of fibrin on its surface; 11 of 20 were covered with a homogeneous layer. Within this layer a net of collagen fibers was detectable. A major cellular reaction was observed only on IOFB that injured the retina, pigment epithelium and choroid.


CONCLUSIONS
This morphologic study shows that: (1) a fibrin net develops in the vitreous around intravitreal IOFB; (2) depositions of amorphous material into the spaces of this net lead to dense coverage of the IOFB; (3) cellular reactions are not condition for the development of this coverage; (4) laceration of the retina induces a fibrocellular response.
Department of Ophthalmology, Christian-Albrechts-University, Kiel, Germany. mwinter@ophthalmol.uni-kiel.de
M
M
Winter
B
B
Wiechens
D000293:Adolescent; D000328:Adult; D000869:Anterior Eye Segment / Q000293:injuries; D003094:Collagen / Q000648:ultrastructure*; D005129:Eye Foreign Bodies / Q000473:pathology* / Q000601:surgery; D015807:Eye Injuries, Penetrating / Q000473:pathology* / Q000601:surgery; D005337:Fibrin / Q000648:ultrastructure*; D006801:Humans; D008670:Metals; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D012160:Retina / Q000293:injuries; D014822:Vitreous Body / Q000293:injuries
D008670:Metals; D005337:Fibrin; D003094:Collagen