Antiinflammatory activity of Anthurium cerrocampanense Croat in rats and mice.
Aqueous (AE), ethanol (EE) and dichloromethane (DE) extracts from the whole plant of Anthurium cerrocampanense Croat, endemic to Panama, were assayed for antiinflammatory activity by carrageenan-induced rat paw edema and croton oil-induced mouse ear edema tests. The extracts were administered i.p. and topically, respectively. The best antiinflammatory activity in the carrageenan-induced rat paw edema test, was shown by DE (31% inhibition), which did not show any irritant effect in the peritoneal examination 4 h after administration of the extracts. Furthermore, the highest activity in the croton oil-induced mouse ear edema test was also exhibited by DE (93% inhibition). Since DE was the most effective of the extracts in both tests, it's activity was assessed in various inflammation models in rats. At 100 mg/kg, DE markedly inhibited inflammation produced by dextran (66.6% inhibition) and decreased weakly the edema induced by zymosan A, carrageenan and C16-platelet activation factor (C16-PAF) (33.2, 31.6 and 23.8%, respectively). At 50 mg/kg, DE only significantly reduced the swelling caused by dextran (36.2%). No effect was observed at the same doses in arachidonic acid-induced edema. A clear dose-related antiinflammatory activity of DE was seen in the croton oil-induced mouse ear edema test, and ED50 calculated was found to be 25.5 microg/ear. which was much lower than ED50 obtained for indomethacin (56.1 microg/ear).
Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Universitat de Barcelona, Spain.
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Segura
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Vila
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MP
Gupta
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Espósito-Avella
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Adzet
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Cañigueral
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000188:drug therapy; D005260:Female; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts