Pain: nocistatin spells relief.
Tissue or nerve injury can dramatically alter the transmission of sensory stimuli by spinal cord neurons, so that a light touch produces pain. The discovery that peptide products of prepronociceptin processing either facilitate or inhibit these mechanisms suggests novel approaches to treating these conditions.
Martin
W J
WJ
Department of Anatomy, University of California at San Francisco 94143-0452, USA.
Malmberg
A B
AB
Basbaum
A I
AI
D000701:Analgesics, Opioid / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D009437:Neuralgia / Q000188:drug therapy*; D018847:Opioid Peptides / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D010147:Pain Measurement; D011493:Protein Kinase C / Q000378:metabolism; D011957:Receptors, Opioid / Q000378:metabolism; D000094942:Nociceptin Receptor
D000701:Analgesics, Opioid; D007527:Isoenzymes; D018847:Opioid Peptides; D011957:Receptors, Opioid; C111148:nocistatin; C087857:protein kinase C gamma; D011493:Protein Kinase C; D000094942:Nociceptin Receptor; C000722283:OPRL1 protein, human