The depression system: preliminary studies.
The learned helplessness paradigm was used to test the notion that lesions of a theatrical depression system in the rat will produce antidepression similar to antidepressive medication. Lateral brain stem lesions were effective in producing antidepression and unilateral lesions were as effective as bilateral lesions. Ibotenic acid lesions were not effective, indicating that the effective target site was in a fiber tract and not a cell nucleus.
Richardson
D E
DE
Tulane Neurosurgery, New Orleans, La., USA. DER@tmc.tulane.edu
Dempsey
C W
CW
Song
J H
JH
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D001933:Brain Stem / Q000187:drug effects / Q000502:physiology*; D003866:Depressive Disorder / Q000188:drug therapy / Q000517:prevention & control* / Q000523:psychology; D004195:Disease Models, Animal; D007839:Functional Laterality / Q000502:physiology; D006380:Helplessness, Learned; D006801:Humans; D007099:Imipramine / Q000494:pharmacology; D009434:Neural Pathways / Q000187:drug effects / Q000502:physiology; D051381:Rats
D007099:Imipramine