N-terminal processing: the methionine aminopeptidase and N alpha-acetyl transferase families.
Removal of the initiator methionine and/or acetylation of the alpha-amino group are among the earliest possible chemical modifications that occur during protein synthesis in eukaryotes. These events are catalyzed by methionine aminopeptidase and N alpha-acetyltransferase, respectively. Recent advances in the isolation and characterization of these enzymes indicate that they exist as isoforms that vary in cellular location, function, and evolutionary origins.
Bradshaw
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RA
Dept of Physiology and Biophysics, College of Medicine, University of California, Irvine 92697, USA.
Brickey
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WW
Walker
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KW
D000123:Acetyltransferases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000626:Aminopeptidases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D019143:Evolution, Molecular; D006801:Humans; D063208:Methionyl Aminopeptidases; D008958:Models, Molecular; D011487:Protein Conformation; D011499:Protein Processing, Post-Translational
D000123:Acetyltransferases; D000626:Aminopeptidases; D063208:Methionyl Aminopeptidases