[The expression of cMET/hepatocyte growth factor receptor in colorectal cancer].
In this study, we estimated the expression of c-MET/Hepatocyte Growth Factor receptor in colorectal cancers by immunohistochemistry. In 118 patients, c-MET wee expressed in 65 patients (55%). About the clinicopathological findings of metastasis, the proportion of c-MET-positive in the patients with liver metastasis, 78% (18/23), was significantly higher than that without liver metastasis, 49% (47/95), but there was no significant difference about lymph node metastasis and peritoneal dissemination. About the pathological findings of primary lesion, the proportion of c-MET-positive in the patients with infiltration into lymphatic vessels, 63% (48/76), was significantly higher than that without infiltration, 40% (17/42), but there was no significant difference about infiltration into veins. The proportion of c-MET-positive increased as the tumor stage proceeded from t1 to t4 and as the histopathological stage proceeded from I to IV. These results suggest that c-MET may play an important role in the growth and scattering of colorectal cancer cells.
Ajisaka
H
H
Second Department of Surgery, Kanazawa University School of Medicine.
Nishimura
G
G
Tsuneda
A
A
Fujita
H
H
Michiwa
Y
Y
Kawamura
T
T
Sato
T
T
Nojima
N
N
Fushida
S
S
Fujimura
T
T
Yonemura
Y
Y
Miwa
K
K
D000230:Adenocarcinoma / Q000378:metabolism* / Q000556:secondary; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003110:Colonic Neoplasms / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000378:metabolism / Q000556:secondary; D008207:Lymphatic Metastasis; D008875:Middle Aged; D019859:Proto-Oncogene Proteins c-met / Q000096:biosynthesis* / Q000502:physiology
D019859:Proto-Oncogene Proteins c-met