Sympathomimetic drug use in adolescents presenting to a pediatric emergency department with chest pain.
BACKGROUND
Drug use has been associated with chest pain in adults presenting for emergency care. The association of drug use and chest pain in adolescents presenting to a pediatric emergency department has not been evaluated.


METHODS
Urine drug testing was conducted in a convenience sample of healthy adolescents with chest pain (cases) and compared to a control group of adolescents presenting with other complaints to a pediatric emergency department. Exclusion criteria were known diagnoses associated with chest pain (e.g., cardiac disease, sickle cell disease) and major trauma (due to its association with drug use). Urine drug testing consisted of 2 screening tests and gas chromatography-mass spectrometry confirmation of all positive or indeterminate results. All patients completed a questionnaire regarding recently prescribed, over-the-counter, and illicit drug use.


RESULTS
Twenty-eight cases and 26 controls completed the study over an 11-month study period. No cases or controls were positive for cocaine whereas marijuana was detected in 7 (25.0%) cases and in 7 (26.7%) controls. Five (17.8%) of the cases but none of the controls were positive for ephedrine (p = 0.05).


CONCLUSIONS
Ephedrine exposure appeared to be associated with chest pain in adolescents presenting for emergency care and marijuana was the most common drug of abuse, regardless of presenting complaint.
University of Arkansas for Medical Sciences, Little Rock, USA. lpjames@exchange.uams.edu
L P
LP
James
H C
HC
Farrar
E M
EM
Komoroski
W R
WR
Wood
C J
CJ
Graham
R A
RA
Bornemeier
J L
JL
Valentine
D000293:Adolescent; D000328:Adult; D002637:Chest Pain / Q000139:chemically induced / Q000652:urine*; D004636:Emergency Service, Hospital; D017248:Enzyme Multiplied Immunoassay Technique; D004809:Ephedrine / Q000009:adverse effects / Q000652:urine*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male; D015813:Substance Abuse Detection / Q000379:methods; D013566:Sympathomimetics / Q000009:adverse effects / Q000652:urine*
D013566:Sympathomimetics; D004809:Ephedrine