HLA supertypes and supermotifs: a functional perspective on HLA polymorphism.
A large fraction of HLA class I, and possibly class II, molecules can be classified into relatively few supertypes, characterized by overlapping peptide-binding repertoires and consensus B- and F-pocket structures. Cross-binding peptides are frequently recognized by specific T cells in the course of natural disease processes and in the context of multiple HLA molecules, validating the concept of HLA supertypes at the functional level.
Sette
A
A
Epimmune Incorporated, San Diego, CA 92121, USA. asette@epimmune.com
Sidney
J
J
D000818:Animals; D003141:Communicable Diseases / Q000276:immunology; D019143:Evolution, Molecular; D006680:HLA Antigens / Q000276:immunology*; D015789:HLA-A2 Antigen / Q000276:immunology; D015791:HLA-A3 Antigen / Q000276:immunology; D006801:Humans; D009369:Neoplasms / Q000276:immunology; D011110:Polymorphism, Genetic
D006680:HLA Antigens; D015789:HLA-A2 Antigen; D015791:HLA-A3 Antigen