Consequences of long-term hyperparathyroidism.
We describe a young woman with long-term untreated hyperparathyroidism with a superimposed vitamin D deficiency and an extremely decreased bone mineral density that was complicated by a vertebral fracture. Despite pretreatment with intravenous pamidronate and short-term vitamin D supplementation, severe and long-standing hypocalcaemia ('hungry bone syndrome') developed after parathyroidectomy. We discuss the consequences of hyperparathyroidism, especially the effects on bone, the complications of parathyroidectomy and the possibilities of preoperative treatment with bisphosphonates.
Department of Endocrinology, University Hospital Maastricht, Netherlands.
M B
MB
Graal
B H
BH
Wolffenbuttel
D000328:Adult; D005260:Female; D005598:Fractures, Spontaneous / Q000209:etiology; D006801:Humans; D006961:Hyperparathyroidism / Q000150:complications* / Q000628:therapy; D016105:Parathyroidectomy / Q000009:adverse effects; D014808:Vitamin D Deficiency / Q000150:complications