Update on plasminogen activator inhibitor-1.
Plasminogen activator inhibitor-1 (PAI-1) is produced by the endothelium and determines the rate and extent of fibrinolysis. Recent data on PAI-1 gene polymorphism and the potential role of glucose in regulating PAI-1 expression in vascular disease are reviewed.
Vaughan
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Cardiology Division, Vanderbilt University, Nashville, TN 37232, USA. doug.vaughan@mcmail.vanderbilt.edu
D001786:Blood Glucose / Q000502:physiology; D002318:Cardiovascular Diseases / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000378:metabolism*; D005342:Fibrinolysis; D005786:Gene Expression Regulation; D006801:Humans; D017395:Plasminogen Activator Inhibitor 1 / Q000096:biosynthesis / Q000502:physiology*; D014652:Vascular Diseases / Q000503:physiopathology*
D001786:Blood Glucose; D017395:Plasminogen Activator Inhibitor 1