[ECG changes after paroxetine. 3 case reports].
Selective serotonin reuptake inhibitors (SSRI) are known to exhibit far less cardiac side effects than tricyclic antidepressants. We report three cases in which the SSRI, paroxetine, induced clinically relevant ECG changes in patients with high risk profile. In two cases an increase in QTc time was observed, severe bradycardia was also observed twice.
Erfurth
A
A
Psychiatrische Klinik der Universität, München.
Loew
M
M
Dobmeier
P
P
Wendler
G
G
D000368:Aged; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects* / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000139:chemically induced* / Q000175:diagnosis; D001919:Bradycardia / Q000139:chemically induced / Q000175:diagnosis; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004562:Electrocardiography / Q000187:drug effects*; D005260:Female; D006801:Humans; D008133:Long QT Syndrome / Q000139:chemically induced / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D017374:Paroxetine / Q000009:adverse effects* / Q000627:therapeutic use
D018687:Antidepressive Agents, Second-Generation; D017374:Paroxetine