[Effect of live tularemia vaccine on some parameters of immune and non-specific antitumor resistance in endometrial cancer patients during combined therapy and later].
The levels of T-system lymphocytes, macrophageal transformation of mononuclears and phagocytic activity of blood neutrophils were assayed in 194 patients with endometrial tumors, stage I-IV, (FIGO, 1988), 10-15 days after surgery, a subsequent course of telegammatherapy and 2-3 years after treatment. Ninety-seven patients of the study group were challenged by immunization with a live tularemia vaccine (LTV) 15-20 days before surgery, while the same number of controls were not. The study was randomized. Pre-operative LTV immunization showed an immunoprotective effect at all stages of combined treatment (surgery + telegammatherapy) given for endometrial carcinoma. Moreover, all said indices came back to normal in the study group 2-3 years after treatment. After surgery alone (standard uterine extirpation or with adnexa), controls with malignancies at the same stages revealed a significant decrease in the indices which fell further after radiotherapy. In the latter group, the indices came back to initial values which were below the norm.
Movsesian
M A
MA
V.A. Fanarjan Center for Cancer Research, Ministry of Health of the Republic of Armenia, Yerevan.
Adamian
R T
RT
D001428:Bacterial Vaccines / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D016889:Endometrial Neoplasms / Q000276:immunology* / Q000628:therapy*; D005260:Female; D006801:Humans; D016233:Immunotherapy, Active / Q000379:methods; D008264:Macrophages; D009504:Neutrophils; D010587:Phagocytosis; D013601:T-Lymphocytes; D013997:Time Factors; D016896:Treatment Outcome; D014406:Tularemia
D001428:Bacterial Vaccines