How do histone acetyltransferases select lysine residues in core histones?
Acetylation of specific lysines of core histone N-terminal tails correlates with chromatin assembly and specific regulation of gene expression. Core histones acetylated at particular lysines mediate effects on chromatin function; however, the manner in which different histone acetyltransferases (HATs) discriminate lysines is unknown. Here we propose a putative rule for lysine selection by HATs based on the primary sequence in the vicinity of lysines in the core histone N-terminal tails and in flanking sequence. This provides insight into the molecular basis of site selection of core histones by HATs.
Kimura
A
A
Department of Cellular Biology, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan.
Horikoshi
M
M
D000107:Acetylation; D000123:Acetyltransferases / Q000378:metabolism*; D000595:Amino Acid Sequence; D002843:Chromatin / Q000502:physiology; D051548:Histone Acetyltransferases; D006657:Histones / Q000145:classification / Q000378:metabolism*; D006801:Humans; D008239:Lysine / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins; D013379:Substrate Specificity
D002843:Chromatin; D006657:Histones; D029701:Saccharomyces cerevisiae Proteins; D000123:Acetyltransferases; D051548:Histone Acetyltransferases; D008239:Lysine