Transcutaneous ethanol injection in hepatocarcinoma: problems in analgesia and sedation.
Therapeutic ethanol injection into primitive or secondary hepatic tumours if performed in "one shot" causes a great deal of pain. For this reason an analgesic/sedation protocol was devised. This relies on the administration of ketorolac-propofol-nitrogen oxide mixture that has been used to treat patients with neoplastic hepatic diseases. A 20 patient series is described. Analgesic protocol was very effective and the only drawbacks were a residual sleepiness than in part is probably dependent on ethanol emigration into the bloodstream and consequently to the central nervous system depression.
Iannarone
C
C
Università degli Studi La Sapienza, Roma, Italy.
Caratozzolo
M
M
Costamagna
L
L
Fegiz
A
A
Tellan
G
G
Baumgartner
I
I
Maselli
A M
AM
Fantera
A
A
D000368:Aged; D000698:Analgesia; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy*; D000431:Ethanol / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D007279:Injections, Subcutaneous; D020910:Ketorolac; D008113:Liver Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000008:administration & dosage*; D014046:Tolmetin / Q000008:administration & dosage / Q000031:analogs & derivatives*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D006993:Hypnotics and Sedatives; D000431:Ethanol; D014046:Tolmetin; D015742:Propofol; D020910:Ketorolac