[Effect of an increased radiation background on mice, carrying lethal t-haplotypes].
To study the effect of a high radiation background on the structure and function of the T-complex, we used laboratory mice carrying t-haplotypes of four complementation groups (t0, t12, tw1, and tw5). In 1987-1989, the animals were kept each year for a month within a 30-kilometer zone of Chernobyl Nuclear Power Station in regions with different degrees of pollution. Subsequent genetic analysis revealed a decrease in fertility, fecundity, and the index of preferable transmission of t-carrying chromosomes in radiated animals and some of their progeny. The effect of different radiation doses on these parameters was different in animals with various t-haplotypes. A lack of complementation or a decrease in the complementation effect was revealed in a number of crosses involving the progeny of irradiated animals. The frequency of complementation distortion was about 8 x 10(-2), which is more than an order higher than the usual recombination frequency characteristic of these t-haplotypes.
Severtsov institute of Ecology and Evolution, Russian Academy of Sciences, Moscow, Russia.
L D
LD
Safronova
I V
IV
Shustrova
V G
VG
Mitrofanov
D000818:Animals; D005260:Female; D005804:Genes, Lethal; D006239:Haplotypes / Q000235:genetics*; D008297:Male; D051379:Mice / Q000235:genetics*; D011210:Power Plants; D018788:Radioactive Hazard Release; D011995:Recombination, Genetic; D014455:Ukraine