Increased urinary albumin excretion is a marker of risk for retinopathy and coronary heart disease in patients with type 2 diabetes mellitus.
The prevalence of increased urinary albumin excretion (UAE) (micro- and macroalbuminuria) and its association with diabetic retinopathy (DR) (evaluated by fluorescent angiography), coronary heart disease (CHD), and various related risk factors were studied in 320 type 2 diabetic patients. In this subsample of type 2 diabetic patients, microalbuminuria was present in 15% of the patients; macroalbuminuria in 4.8%, CHD in 9.9%, DR in 53.4%, and arterial hypertension in 46%. UAE was independently related to CHD (P < 0.05), retinopathy (P < 0.001), hypertension (P < 0.001), and triglycerides (P < 0.02). We conclude that increased UAE is associated to a greater frequency of retinopathy and CHD in type 2 diabetic patients.
Lunetta
M
M
Department of Internal Medicine, University of Catania Medical School, Italy.
Infantone
L
L
Calogero
A E
AE
Infantone
E
E
D000368:Aged; D000419:Albuminuria / Q000453:epidemiology / Q000652:urine*; D015415:Biomarkers / Q000652:urine; D003327:Coronary Disease / Q000209:etiology / Q000652:urine*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000652:urine*; D003925:Diabetic Angiopathies / Q000652:urine*; D003930:Diabetic Retinopathy / Q000652:urine*; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000150:complications; D006973:Hypertension / Q000150:complications; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors
D015415:Biomarkers; D008055:Lipids