Hemispheric specialization in schizophrenics with perceptual aberration.
Higher rates of left-handedness and atypical lateralization in schizophrenics paired with findings of morphological abnormalities in cerebral asymmetry suggest that the normal patterns of hemisphere specialization for processing verbal and spatial information may be anomalous in schizophrenics. The small number of studies that have addressed this question have produced inconsistent findings and varied with subtype diagnosis, gender, type of task employed, task difficulty, and control of handedness. Conflicting research findings also may be due to confounding from the heterogeneity of the schizophrenic construct and variability in clinical symptoms across patients. The present study was designed to control for factors that may have confounded earlier studies. Because the study used perceptual measures, the relationship between symptoms of perceptual aberration and hemisphere advantages was examined using Chapman et al.'s (1978) Perceptual Aberration Scale (PAS). Fifteen male schizophrenic patients and 14 male controls were administered tachistoscopic letter and facial recognition go/no-go reaction time tasks. Left hemisphere advantages were found for both controls and schizophrenics on the letter task. Right hemisphere advantages were found for controls on the facial task but not schizophrenics. Instead, a strong negative correlation was found between schizophrenics' PAS scores and hemisphere advantages (r = -0.685, p < 0.007). Further analysis identified a subgroup of schizophrenics with perceptual aberration who exhibited reversed left hemisphere advantages that increased as the PAS scores increased. Additional research is needed to determine whether this subgroup of schizophrenics constitutes a meaningful subtype with a distinct disease process that disrupts the development of normal cerebral lateralization. The findings provide further evidence for the importance of examining relationships between schizophrenics' performance on cognitive measures and their symptom patterns.
Department of Psychology, Harvard University, Cambridge, MA 02138, USA. mswhite@fas.harvard.edu
M S
MS
White
B A
BA
Maher
T C
TC
Manschreck
D000328:Adult; D005145:Face; D007839:Functional Laterality; D006801:Humans; D008297:Male; D011939:Mental Recall; D010468:Perceptual Disorders / Q000503:physiopathology; D012559:Schizophrenia / Q000503:physiopathology*