A case of Gitelman's syndrome with chondrocalcinosis.
A 45-year-old Japanese woman, treated for Bartter's syndrome for 14 years, presented with complaints of numbness in her extremities and polyarthralgia. She was diagnosed to have Gitelman's syndrome with chondrocalcinosis, which were effectively treated with spironolactone and magnesium supplementation. Gitelman's syndrome is a primary renal tubular disorder characterized by hypomagnesemia and hypocalciuria with normal calcemia. The persistent hypomagnesemia is one of the causes of chondrocalcinosis, and many cases of Bartter's syndrome with hypomagnesemia are associated with chondrocalcinosis attributed to a tubular magnesium defect. We summarize the reported cases with Bartter's syndrome and chondrocalcinosis, referring to the possibility of Gitelman's syndrome.
Hisakawa
N
N
Second Department of Internal Medicine, Kochi Medical School, Japan.
Yasuoka
N
N
Itoh
H
H
Takao
T
T
Jinnouchi
C
C
Nishiya
K
K
Hashimoto
K
K
D001477:Bartter Syndrome / Q000175:diagnosis; D002118:Calcium / Q000652:urine; D002805:Chondrocalcinosis / Q000150:complications*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007008:Hypokalemia / Q000150:complications* / Q000188:drug therapy; D008274:Magnesium / Q000627:therapeutic use; D008275:Magnesium Deficiency / Q000150:complications* / Q000188:drug therapy; D008875:Middle Aged; D013148:Spironolactone / Q000627:therapeutic use; D013577:Syndrome
D013148:Spironolactone; D008274:Magnesium; D002118:Calcium