Rhinocerebral mycosis in immunocompromised patients. A case report and review of the literature.
Continuous awareness of systemic mycosis in immunocompromised patients is important. Early diagnosis is based on (direct) histologal examination and CT scan. Since treatment should start as early as possible, there is usually no time to await results of tissue cultures. Systemic treatment with amphotericin B and aggressive surgical débridement should be performed as soon as possible, while the place of hyperbaric oxygen and G-CSF remains to be established. In addition to routine preventive measures, prophylactic intranasal application of amphotericin B seems to be of value.
Academic Hospital Dijkzigt, Department of Otorhinolaryngology-Head and Neck Surgery, Rotterdam, The Netherlands.
J M
JM
Schmidt
R M
RM
Poublon
D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000628:therapy*; D001927:Brain Diseases / Q000628:therapy*; D002648:Child; D003646:Debridement; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D006931:Hyperbaric Oxygenation; D016867:Immunocompromised Host; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000628:therapy*; D010254:Paranasal Sinus Diseases / Q000628:therapy*; D016896:Treatment Outcome
D000935:Antifungal Agents; D016179:Granulocyte Colony-Stimulating Factor; D000666:Amphotericin B