Myositis ossificans progressiva: five generations where the disease was exclusively limited to the maxillofacial region. A case report.
Myositis ossificans progressiva is an unusual autosomal-dominant inherited disease characterized by congenital malformations and osseous metaplasia of the fascia of the muscles and connective tissue leading to ossification of the relevant area. The case report is remarkable in that eight members of the same family over five generations manifested the exclusive localization of the disease in the maxillofacial region.
Clinique et UFR de Stomatologie et de Chirurgie Maxillo-facial, Hôpital de la Salpêtrière, Paris, France. estelle.favre-dauvergne@psl.ap-hop-paris.fr
C
C
Debeney-Bruyerre
L
L
Chikhani
R
R
Lockhart
E
E
Favre-Dauvergne
B
B
Weschler
J C
JC
Bertrand
F
F
Guilbert
D000328:Adult; D003238:Connective Tissue / Q000473:pathology; D018450:Disease Progression; D005205:Fascia / Q000473:pathology; D005260:Female; D005799:Genes, Dominant; D006801:Humans; D008406:Masseter Muscle / Q000473:pathology; D009221:Myositis Ossificans / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D009999:Ossification, Heterotopic / Q000473:pathology; D010375:Pedigree; D011626:Pterygoid Muscles / Q000473:pathology* / Q000503:physiopathology; D013703:Temporal Muscle / Q000473:pathology