[Mycophenolate mofetil].
Mycophenolate Mofetil (MMF) is a new immunosuppressive agent that selectively inhibits the proliferation of T and B lymphocytes. The use of MMF in renal transplantation significantly reduced the incidence of acute rejection episodes in the first year after transplantation. The main toxicities of MMF are the occurrence of diarrhea and leucopenia. This potent immunosuppressive agent is devoid of the nephrotoxicity of cyclosporin and of the multiple adverse effects of corticosteroids. Clinical trials are currently in progress to assess whether the use of MMF will allow the discontinuation of cyclosporine or corticosteroid therapy without leading to an increased risk of rejection. If results were positive, MMF would represent a significant advance in the field of renal transplantation.
Abramowicz
D
D
Service de Néphrologie, Hôpital Erasme, U.L.B.
Broeders
N
N
Wissing
M
M
Sternon
J
J
D000208:Acute Disease; D000305:Adrenal Cortex Hormones / Q000009:adverse effects; D001402:B-Lymphocytes / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002986:Clinical Trials as Topic; D016572:Cyclosporine / Q000009:adverse effects; D003967:Diarrhea / Q000139:chemically induced; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D015994:Incidence; D007668:Kidney / Q000187:drug effects; D016030:Kidney Transplantation / Q000276:immunology; D007970:Leukopenia / Q000139:chemically induced; D009173:Mycophenolic Acid / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012307:Risk Factors; D013601:T-Lymphocytes / Q000187:drug effects
D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D009173:Mycophenolic Acid