High molecular mass dextran sulfate increases expression of HIV-1 coreceptor CCR-5 in macrophage-monocytes in culture.
It has been reported that high molecular mass dextran sulfate (HMDS) enhances the infection of monocyte-macrophages by HIV-1. We observed that in monocyte-macrophages maintained in the presence of HMDS the expression of HIV-1 coreceptor CCR-5 was increased approximately 5-fold at the transcriptional level. We postulate that the increased expression of CCR-5 might be responsible for HMDS-enhanced infectivity of monocyte-macrophages by HIV-1.
Department of Physiological Chemistry, University of Medical Sciences, Poznań, Poland.
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Jagodzinski
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Trzeciak
D002478:Cells, Cultured; D003470:Culture Media; D016264:Dextran Sulfate / Q000494:pharmacology*; D005936:Glucans / Q000494:pharmacology; D018023:HIV Seronegativity; D015497:HIV-1; D006801:Humans; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D008970:Molecular Weight; D009000:Monocytes / Q000187:drug effects* / Q000378:metabolism; D016133:Polymerase Chain Reaction; D019713:Receptors, CCR5 / Q000096:biosynthesis*; D014158:Transcription, Genetic
D003470:Culture Media; D005936:Glucans; D019713:Receptors, CCR5; C078962:glucan sulfate; D016264:Dextran Sulfate