How is the intracellular fate of the Legionella pneumophila phagosome determined?
The following pair of articles, the first by Gil Segal and Howard Shuman, and the second by James Kirby and Ralph Isberg (Trends Microbiol. 6, 256-258), explore the genetics and function of the icm/dot genes of Legionella pneumophila. This gene family is implicated in several aspects of virulence and appears to constitute components of a conjugal transfer system that has been adopted to prevent phagosome-lysosome fusion in the host cell and to mediate host cytotoxicity by pore formation. Whether these functions are natural consequences or operate in parallel remains to be discovered.
Dept of Microbiology, College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA.
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Segal
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Shuman
D005798:Genes, Bacterial / Q000502:physiology; D016952:Legionella pneumophila / Q000472:pathogenicity*; D010588:Phagosomes / Q000382:microbiology*