Protective immunity induced by live attenuated simian immunodeficiency virus.
Lack of information on the mechanisms of protective immunity to AIDS virus infection represents a major obstacle to the development of a rational strategy for an effective HIV vaccine. In macaques, immunization with live attenuated simian immunodeficiency viruses has induced the most potent protective immunity and continued study promises a better understanding of the nature of protective immune responses. Recent evidence supports involvement of both cytotoxic T lymphocytes and neutralizing antibodies in protective immunity against infection by simian immunodeficiency virus, but more detailed studies are needed to document their relative importance.
Johnson
R P
RP
Division of Immunology, New England Regional Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA. pjohnson@warren.med.harvard.edu
Desrosiers
R C
RC
D000818:Animals; D000917:Antibody Formation; D015693:Gene Products, nef; D006801:Humans; D007111:Immunity, Cellular; D008251:Macaca; D016296:Mutagenesis; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000517:prevention & control*; D015302:Simian Immunodeficiency Virus / Q000235:genetics / Q000276:immunology*; D013242:Sterilization; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000276:immunology; D014762:Viral Interference; D014765:Viral Vaccines / Q000276:immunology*
D015693:Gene Products, nef; D014613:Vaccines, Attenuated; D014765:Viral Vaccines