Peptidomimetic growth hormone secretagogues. Design considerations and therapeutic potential.
Nargund
R P
RP
Departments of Medicinal Chemistry, Clinical Pharmacology, Clinical Sciences, and Biochemistry and Physiology, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, USA.
Patchett
A A
AA
Bach
M A
MA
Murphy
M G
MG
Smith
R G
RG
D000595:Amino Acid Sequence; D000818:Animals; D015195:Drug Design; D013007:Growth Hormone-Releasing Hormone / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000502:physiology*; D006728:Hormones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D019382:Human Growth Hormone / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011487:Protein Conformation; D011986:Receptors, Somatotropin / Q000737:chemistry / Q000502:physiology*
D006728:Hormones; D009842:Oligopeptides; D011986:Receptors, Somatotropin; D019382:Human Growth Hormone; D013007:Growth Hormone-Releasing Hormone