New insights into mullerian inhibiting substance and its mechanism of action.
The primary function of MIS in mammals is to initiate regression of Mullerian structures in males as part of normal sexual development. As we learn more about its other roles, particularly its influence on the growth and differentiation of cell types within the gonad, a more thorough understanding of the receptors that MIS stimulates and the downstream signaling cascade with which it interacts will help in the development of diagnostic and therapeutic uses of MIS.
Pediatric Surgical Research Laboratories, Massachusetts General Hospital, Boston 02114, USA.
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D000818:Animals; D054304:Anti-Mullerian Hormone; D002417:Cattle; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology*; D006023:Glycoproteins; D006131:Growth Inhibitors / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008297:Male; D051379:Mice; D009095:Mullerian Ducts / Q000502:physiology*; D051381:Rats; D012733:Sex Differentiation / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D013735:Testicular Hormones / Q000235:genetics / Q000502:physiology*
D006023:Glycoproteins; D006131:Growth Inhibitors; D013735:Testicular Hormones; D054304:Anti-Mullerian Hormone