The PTX family of homeodomain transcription factors during pituitary developments.
A subfamily of bicoid-related homeodomain factors was recently discovered through its involvement in transcription of pituitary-specific genes. We isolated the first member of this family, Ptxl (pituitary homeobox 1), through its DNA binding properties whereas a second related gene, Ptx2 (RIEG), was identified by positional cloning as the causative gene for Rieger's syndrome. The mechanisms of Ptx action on its target genes as well as its putative roles during development are reviewed with particular emphasis on its role in pituitary function.
Laboratoire de Génétique Moléculaire, Institut de recherches cliniques de Montréal, Québec, Canada. drouinj@ircm.umontreal.ca
J
J
Drouin
B
B
Lamolet
T
T
Lamonerie
C
C
Lanctôt
J J
JJ
Tremblay
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics; D029721:Drosophila Proteins; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D005810:Multigene Family; D009687:Nuclear Proteins; D051761:Paired Box Transcription Factors; D010902:Pituitary Gland / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D020218:Response Elements / Q000235:genetics; D015534:Trans-Activators / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism; D015533:Transcriptional Activation / Q000235:genetics; D000097577:Homeobox Protein PITX2
D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D009687:Nuclear Proteins; D051761:Paired Box Transcription Factors; D015534:Trans-Activators; D014157:Transcription Factors; D000097577:Homeobox Protein PITX2; C056478:bcd protein, Drosophila; C101485:homeobox protein PITX1