Nociceptive neurons in the macaque anterior cingulate activate during anticipation of pain.
Since the anterior cingulate cortex (ACC) is known to be involved both in nociception and in anticipation that precedes the avoidance of aversive stimuli, the linking of these functions may be processed in the ACC. To test this hypothesis, we recorded single neuronal activities in the ACC of a macaque monkey while it was performing a pain-avoidance task and examined them with nociceptive cutaneous electric stimuli (ES). Thirty-six neurons responded in anticipation of the ES. Of these, 22 neurons were tested with the ES and 11 responded. These neurons could be those that are involved both in nociception and in pain anticipation that precedes the avoidance of noxious stimuli.
Koyama
T
T
Department of Behavioral and Brain Sciences, Primate Research Institute, Kyoto University, Inuyama, Aichi, Japan.
Tanaka
Y Z
YZ
Mikami
A
A
D000818:Animals; D001362:Avoidance Learning / Q000502:physiology; D004558:Electric Stimulation; D004594:Electrophysiology; D004924:Escape Reaction / Q000502:physiology; D005260:Female; D006179:Gyrus Cinguli / Q000166:cytology* / Q000503:physiopathology*; D008253:Macaca mulatta; D009475:Neurons, Afferent / Q000502:physiology*; D009619:Nociceptors / Q000502:physiology*; D010146:Pain / Q000503:physiopathology* / Q000523:psychology*; D012201:Reward