RTI-113 administration reduces cocaine self-administration at high occupancy of dopamine transporter.
RTI-113 [3beta-(4-chlorophenyl)tropan-2beta carboxylic acid phenyl ester hydrochloride], one of many phenyltropanes potent at and selective for DAT, inhibited self-administration of cocaine in rat at doses that did not alter responding maintained by food. The doses that inhibited cocaine intake produced significant levels of occupancy of DAT.
Dworkin
S I
SI
Bowman Gray School of Medicine, Winston Salem, North Carolina 27103, USA.
Lambert
P
P
Sizemore
G M
GM
Carroll
F I
FI
Kuhar
M J
MJ
D000818:Animals; D003042:Cocaine / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005108:Extinction, Psychological; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D012054:Reinforcement, Psychology; D012646:Self Administration; D019966:Substance-Related Disorders / Q000517:prevention & control*
C114870:RTI-113; D003042:Cocaine