[Anti-retroviral therapy and antiepileptics. Case report and discussion].
Therapy of HIV infection is changing rapidly as new drugs are introduced. Many patients with HIV infection require anticonvulsants for therapy or prophylaxis of seizures. Antiretroviral drugs, above all protease inhibitors, and anticonvulsants may cause interactions since they are metabolised through common hepatic pathways and may substantially modulate the activity of numerous cytochrome P450 isoenzymes. We describe known interactions between anticonvulsants and antiretroviral drugs and advise on possible combinations.
Hug
B
B
Medizinische Universitätspoliklinik, Departement Innere Medizin, Kantonsspital Basel.
Kaeser
Y A
YA
Haefeli
W E
WE
Battegay
M
M
D000328:Adult; D000927:Anticonvulsants / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D011480:Protease Inhibitors / Q000493:pharmacokinetics / Q000627:therapeutic use*; D012190:Retroviridae / Q000187:drug effects*
D000927:Anticonvulsants; D000998:Antiviral Agents; D011480:Protease Inhibitors