Reproductive endpoints in general toxicity studies: are they predictive?
The ability to use necropsy and in-life vaginal cytology data from 90-d general toxicity studies to predict the outcome of more definitive reproductive toxicity tests was evaluated using data from 18 compounds tested by the National Toxicology Program. Sperm motility and vaginal cytology evaluations (SMVCE) were performed at the end of 90-d toxicity studies. When these same compounds were tested in the definitive Reproductive Assessment by Continuous Breeding (RACB) design, 13 of the 18 compounds were classified the same way by both tests. The different conclusions for five compounds can be explained by differences in dose used or in endpoints evaluated. We conclude that reproductive-system necropsy data from general toxicity studies can provide a valuable preliminary indication of the likely reproductive toxicity of the compound under study.
Reproductive Toxicology Group, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. chapin@niehs.nih.gov
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RE
Chapin
R A
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Sloane
J K
JK
Haseman
D000818:Animals; D005260:Female; D008297:Male; D051379:Mice; D051381:Rats; D011916:Rats, Inbred F344; D012098:Reproduction / Q000187:drug effects*; D013081:Sperm Motility / Q000187:drug effects; D014116:Toxicology / Q000379:methods*; D014621:Vagina / Q000187:drug effects / Q000473:pathology