A large sample of finnish diabetic sib-pairs reveals no evidence for a non-insulin-dependent diabetes mellitus susceptibility locus at 2qter.
In the first reported positive result from a genome scan for non-insulin-dependent diabetes mellitus (NIDDM), Hanis et al. found significant evidence of linkage for NIDDM on chromosome 2q37 and named the putative disease locus NIDDM1 (Hanis et al. 1996. Nat. Genet. 13:161-166). Their total sample was comprised of 440 Mexican-American affected sib-pairs from 246 sibships. The strongest evidence for linkage was at marker D2S125 and best estimates of lambdas (risk to siblings of probands/population prevalence) using this marker were 1.37 under an additive model and 1.36 under a multiplicative model. We examined this chromosomal region using linkage analysis in a Finnish sample comprised of 709 affected sib-pairs from 472 sibships. We excluded this region in our sample (multipoint logarithm of odds score </= -2) for lambdas >/= 1.37. We discuss possible reasons why linkage to 2q37 was not found and conclude that this region is unlikely to be playing a major role in NIDDM susceptibility in the Finnish Caucasian population.
Ghosh
S
S
Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. sghosh@alw.nih.gov
Hauser
E R
ER
Magnuson
V L
VL
Valle
T
T
Ally
D S
DS
Karanjawala
Z E
ZE
Rayman
J B
JB
Knapp
J I
JI
Musick
A
A
Tannenbaum
J
J
Te
C
C
Eldridge
W
W
Shapiro
S
S
Musick
T
T
Martin
C
C
So
A
A
Witt
A
A
Harvan
J B
JB
Watanabe
R M
RM
Hagopian
W
W
Eriksson
J
J
Nylund
S J
SJ
Kohtamaki
K
K
Tuomilehto-Wolf
E
E
Boehnke
M
M
D000368:Aged; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics*; D004198:Disease Susceptibility; D005260:Female; D005387:Finland / Q000453:epidemiology; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D016013:Likelihood Functions; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D009679:Nuclear Family; D044465:White People / Q000235:genetics
D005819:Genetic Markers