Human liver cytochrome P-450 and conjugating enzymes. Hungarian data.
Cytochrome P-450 and the conjugating enzymes of the liver are the most important enzymes in the detoxification of xenobiotics. In order to get direct data in the Hungarian human population the activity of liver cytochrome P-450 enzymes (CYP1A2, 2A6, 2C19, 2D6, E1, 3A4) and of the conjugating enzymes has been determined in 11 Hungarian tissue donors died in accidents or in brain vascular catastrophe, by using specific enzymic reactions. In the activity of cytochrome P-450 enzymes a wide range has been found, a ten-fold difference being rather common. In the activities of conjugating enzymes the differences seem to be less.
Department of Biochemical Pharmacology, Central Research Institute of the Hungarian Academy of Sciences, Budapest, Hungary.
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Vereczkey
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Jemnitz
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Monostory
D015660:7-Alkoxycoumarin O-Dealkylase / Q000378:metabolism; D001189:Aryl Hydrocarbon Hydroxylases; D065637:Cytochrome P-450 CYP2A6; D065731:Cytochrome P-450 CYP2C19; D019389:Cytochrome P-450 CYP2D6 / Q000378:metabolism; D019392:Cytochrome P-450 CYP2E1 / Q000378:metabolism; D051544:Cytochrome P-450 CYP3A; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D014453:Glucuronosyltransferase / Q000378:metabolism; D006801:Humans; D006814:Hungary; D008658:Inactivation, Metabolic; D008099:Liver / Q000201:enzymology* / Q000378:metabolism*; D006899:Mixed Function Oxygenases / Q000378:metabolism; D012016:Reference Values; D015262:Xenobiotics / Q000493:pharmacokinetics
D015262:Xenobiotics; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D015660:7-Alkoxycoumarin O-Dealkylase; D019392:Cytochrome P-450 CYP2E1; D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; C104464:CYP3A protein, human; D065637:Cytochrome P-450 CYP2A6; D065731:Cytochrome P-450 CYP2C19; D019389:Cytochrome P-450 CYP2D6; D051544:Cytochrome P-450 CYP3A; D014453:Glucuronosyltransferase