Phagocytes in ischemia injury.
We are now developing the means to evaluate components of this inflammatory response that may facilitate healing. A key event in the change in the inflammatory response is the development of a cytokine cascade that promotes phenotypic changes in the infiltrating leukocytes, which endow them with the ability to promote fibroblast proliferation and collagen deposition, the hallmarks of healing.
Youker
K A
KA
Methodist Hospital, DeBakey Heart Center, Department of Medicine, Philadelphia, Pennsylvania, USA.
Birdsall
H H
HH
Frangogiannis
N G
NG
Kumar
A G
AG
Lindsey
M L
ML
Ballantyne
C M
CM
Smith
C W
CW
Rossen
R D
RD
Entman
M L
ML
D000818:Animals; D002634:Chemotaxis, Leukocyte; D003326:Coronary Circulation / Q000502:physiology*; D004285:Dogs; D005260:Female; D005434:Flow Cytometry; D006636:Histamine Release; D007963:Leukocytes, Mononuclear / Q000502:physiology; D008196:Lymph / Q000276:immunology; D008297:Male; D009000:Monocytes / Q000502:physiology; D017202:Myocardial Ischemia / Q000097:blood / Q000276:immunology / Q000503:physiopathology*; D015425:Myocardial Reperfusion; D009206:Myocardium / Q000378:metabolism; D010586:Phagocytes / Q000502:physiology*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D014409:Tumor Necrosis Factor-alpha