Fermenting debate: do yeast undergo apoptosis?
Apoptosis is a common feature of multicellular organisms. However, the recent observations of non-metazoan cell deaths displaying morphology reminiscent of apoptosis has suggested the existence of an ancestral cell death machinery. We discuss this possibility and its implications for the use of yeast in the dissection of the metazoan apoptotic process.
Fraser
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Hengartner Laboratory, Cold Spring Harbor Laboratory, NY 11724, USA. frasera@cshl.org
James
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D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D017173:Caenorhabditis elegans / Q000166:cytology; D012441:Saccharomyces cerevisiae / Q000166:cytology*; D012568:Schizosaccharomyces / Q000166:cytology