Monoclonal antibodies to CD4.
Animal models of human autoimmune disease suggest that it should be possible to reinduce self-tolerance in these conditions by the use of T-cell directed therapies, in particular with anti-CD4 monoclonal antibodies (CD4-mAb). Many studies have shown that CD4-mAb can prevent and in a treatment setting suppress activity of these disease models, including collagen-induced arthritis.
Department of Rheumatology, Leiden University Medical Center, The Netherlands. F.C.Breeveld@Rheumatology.MedFac.LeidenUniv
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Breedveld
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000628:therapy; D015704:CD4 Antigens / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation / Q000276:immunology; D051379:Mice; D051381:Rats
D000911:Antibodies, Monoclonal; D015704:CD4 Antigens