In situ hybridization: a possible diagnostic aid in leptomeningeal metastasis.
In this review we discuss the clinical features and pathophysiology of leptomeningeal metastasis (LM), and elaborate on diagnostic tools for the detection of this serious complication of cancer. Because of the low sensitivity of the cytologic examination, new diagnostic approaches have been developed. The in situ hybridization technique may prove to be a reliable and early test for the detection of LM.
van Oostenbrugge
R J
RJ
Department of Neurology, University Hospital Maastricht, The Netherlands.
Hopman
A H
AH
Ramaekers
F C
FC
Twijnstra
A
A
D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D006801:Humans; D017403:In Situ Hybridization; D017254:Leukemic Infiltration / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics / Q000473:pathology*; D008545:Melanoma / Q000235:genetics / Q000473:pathology; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000556:secondary*; D008578:Meninges / Q000473:pathology*
D004273:DNA, Neoplasm