Neuropathy associated with angioimmunoblastic lymphadenopathy-like T-cell lymphoma.
A 75-year-old woman was admitted because of pain and numbness in the extremities and trunk. She subsequently suffered from lymphadenopathy and spiky fever. The immunohistochemical analysis of the biopsied lymph nodes and sural nerve and electrophysiological examination supported a diagnosis of angioimmunoblastic lymphadenopathy-like T cell lymphoma with polyneuropathy. The infiltrating lymphoma cells of the sural nerve and lymph node shared the same phenotype (CD45RO, CD3, CD30 positive). An increased expression of HLA-DR antigen was observed in endothelial and Schwann cells. Chemotherapy with CHOP-Bleomycin markedly relieved her pain. These findings suggest that a direct lymphocytic infiltration in the nerve may be associated with neuropathy in this case.
Third Department of Medicine, Shiga University of Medical Science, Ohtsu.
M
M
Sonobe
H
H
Yasuda
H
H
Okabe
M
M
Terada
K
K
Maeda
T
T
Kawabata
R
R
Kikkawa
D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001761:Bleomycin / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D007124:Immunoenzyme Techniques; D016130:Immunophenotyping; D008198:Lymph Nodes / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D011241:Prednisone / Q000627:therapeutic use; D013497:Sural Nerve / Q000473:pathology; D014750:Vincristine / Q000627:therapeutic use
D015703:Antigens, CD; D006684:HLA-DR Antigens; D001761:Bleomycin; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone