[Common physicochemical characteristics of endogenous hormones-- liberins and statins].
The common chemical features of oligopeptide releasing-hormones and release inhibiting hormones were investigated with the aid of computer methods. 339 regulatory molecules of such type have been extracted out of data from computer bank EROP-Moscow. They contain from 2 to 47 amino acid residues and their sequences include short sites, which play apparently a decisive role in realization of interactions with the receptors. The analysis of chemical radicals shows that all liberins and statins contain positively charged group and cyclic radical of some amino acids or hydrophobic group. Results of this study indicate that the most chemical radicals of hormones are open for the interaction with potential receptors of target-cells. The mechanism of hormone ligand and receptors binding and conceivable role of amino acid and neurotransmitter radicals in hormonal properties of liberins and statins is discussed.
Bakh Institute of Biochemistry, Russian Academy of Sciences, Moscow, Russia.
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Zamiatnin
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Voronina
D000595:Amino Acid Sequence; D000818:Animals; D016208:Databases, Factual; D006728:Hormones / Q000737:chemistry* / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000737:chemistry* / Q000235:genetics; D016415:Sequence Alignment; D017421:Sequence Analysis; D012984:Software
D006728:Hormones; D009842:Oligopeptides