[The role of tissue factor and its inhibitor in hemostasis].
TF (tissue factor) is a physiological inhibitor of blood coagulation in normal hemostasis and is a major initiator of clotting in thrombotic disease. TF functions as a protein cofactor for FVIIa. Coagulation at a site of injury is initiated by exposure of blood to cell-surface formation of TF/VIIa complex. The TF/VIIa complex then activates both factors IX and X leading to thrombin generation and fibrin formation. TFPI (tissue factor pathway inhibitor) appears to play a primary role in regulating TF-induced coagulation. Abnormal coagulation may contribute to the pathogenesis of many serious illnesses. In particular, induced expression of TF and TF-mediated coagulation occurs in atherosclerotic plaques, sepsis, malignancy, ARDS and glomerulonephritis. Several observations support the need for exogenous TFPI administration to effectively turn off the TF/VIIa complex in several clinical conditions with TF-induced coagulopathy. There are some reports about successful administration of rTFPI for antithrombotic therapy in humans.
Naumnik
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B
Kliniki Nefrologii i Chorób Wewnetrznych, Akademii Medycznej w Białymstoku.
Małyszko
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J
Myśliwiec
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M
D000818:Animals; D000925:Anticoagulants / Q000627:therapeutic use; D001777:Blood Coagulation / Q000502:physiology; D001778:Blood Coagulation Disorders / Q000503:physiopathology / Q000628:therapy; D004347:Drug Interactions; D065427:Factor Xa Inhibitors; D006487:Hemostasis / Q000502:physiology*; D006493:Heparin / Q000494:pharmacology; D006801:Humans; D008074:Lipoproteins / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use; D012016:Reference Values; D013925:Thromboplastin / Q000502:physiology*
D000925:Anticoagulants; D065427:Factor Xa Inhibitors; D008074:Lipoproteins; C051928:lipoprotein-associated coagulation inhibitor; D006493:Heparin; D013925:Thromboplastin