Characteristics of the immunological response in the clearance of non-typeable Haemophilus influenzae from the lung.
Clearance of non-typeable Haemophilus influenzae (NTHi) from the respiratory tract was investigated, over time, in immune and non-immune rats. A triphasic pattern characterized the clearance of bacteria from the lungs. Mucosal immunization enhanced bacterial clearance from the lungs in each of the three phases compared with clearance from non-immunized animals. Total clearance of bacteria was observed from lung tissue by 12 h in immune animals and 24 h in non-immune animals. Polymorphonuclear leucocytes not only arrived earlier and initially in greater numbers, but disappeared earlier in immune animals (peaking at 8 h post-challenge), compared with non-immune animals (peaking at 12h post-challenge). Systemically derived and locally produced NTHi-specific IgA and IgG correlated with enhanced bacterial clearance during the secondary phase. This model demonstrates that immunized animals up-regulate and resolve inflammatory responses to pulmonary infection more rapidly than the non-immunized controls.
Foxwell
A R
AR
Research Centre for Human and Biomedical Sciences, Faculty of Applied Science, University of Canberra, Australian Capital Territory, ACT.
Kyd
J M
JM
Cripps
A W
AW
D000328:Adult; D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology; D001808:Blood Vessels; D001991:Bronchitis / Q000276:immunology / Q000378:metabolism; D001992:Bronchoalveolar Lavage Fluid / Q000276:immunology; D006192:Haemophilus Infections / Q000276:immunology; D006193:Haemophilus influenzae / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology; D007962:Leukocytes / Q000276:immunology; D008168:Lung / Q000276:immunology* / Q000382:microbiology; D008297:Male; D009504:Neutrophils / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar; D014611:Vaccination
D000907:Antibodies, Bacterial