The macrophage-induced gene mig as a marker for clinical pathogenicity and in vitro virulence of Mycobacterium avium complex strains.
The capacity of 20 Mycobacterium avium complex isolates to multiply intracellularly in human monocyte-derived macrophages was assessed and correlated to the clinical relevance of each isolate and its reactivity with several candidate genetic virulence markers. The strongest correlation with a virulence phenotype was found for a conserved coding sequence of the macrophage-induced gene mig identified by a specific mig restriction fragment length polymorphism type.
Meyer
M
M
Institut für Medizinische Mikrobiologie und Hygiene, Universität zu Köln, D-50935 Cologne, Germany.
von Grünberg
P W
PW
Knoop
T
T
Hartmann
P
P
Plum
G
G
D015415:Biomarkers; D005798:Genes, Bacterial; D006801:Humans; D008264:Macrophages / Q000382:microbiology*; D015269:Mycobacterium avium Complex / Q000235:genetics / Q000472:pathogenicity*; D015270:Mycobacterium avium-intracellulare Infection / Q000378:metabolism / Q000503:physiopathology; D014774:Virulence
D015415:Biomarkers