Quality control in manufacturing process by near infrared spectroscopy.
The combination of a pattern recognition technique with near infrared spectroscopy (NIR) to determine the conformity of a pharmaceutical mixture can be used in the routine checking of a pharmaceutical product. All the chemical and physical characteristics of the product that influence the NIR spectrum affect the qualification. The qualification is used to determine several deviations in the process: moisture, particle size and non-homogeneity. This work presents a method for the qualification analysis of a pharmaceutical mixture using the standard software of the instrument and a new program (DISPLOT). This program allows the acquisition of the plot of the scaled distances with its sign vs the wavelength.
González
F
F
Quality Control Department, Laboratorios Almirall, S.A. Crta. Nacional II, Barcelona, Spain.
Pous
R
R
D004338:Drug Combinations; D004339:Drug Compounding / Q000592:standards*; D004345:Drug Industry / Q000592:standards; D010363:Pattern Recognition, Automated; D011786:Quality Control; D012984:Software; D013055:Spectrophotometry, Infrared
D004338:Drug Combinations