HIV-2 and T cell recognition.
HIV-2 is less pathogenic and less transmissible than HIV-1. Recent research in relation to deletions in the HIV nef gene and to immune cross-reactions between infections by HIV-2, HIV-1 and simian immunodeficiency virus suggests that T cell recognition and the control of viral replication may be more efficient in HIV-2 infection than in HIV-1 infection. These insights may be crucial to the design of effective vaccines.
Whittle
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HC
MRC Laboratories, The Gambia, West Africa. whittle@commit.gm
Ariyoshi
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K
Rowland-Jones
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S
D016915:AIDS Vaccines; D000818:Animals; D015658:HIV Infections / Q000453:epidemiology / Q000821:virology*; D015497:HIV-1 / Q000276:immunology; D015498:HIV-2 / Q000235:genetics / Q000276:immunology*; D006801:Humans; D013601:T-Lymphocytes / Q000276:immunology*; D014613:Vaccines, Attenuated
D016915:AIDS Vaccines; D014613:Vaccines, Attenuated