Internal motions of native lysozyme are more organized than those of mutants: a principal component analysis of molecular dynamics data.
Principal component analysis (PCA) of molecular dynamics simulations of hen egg white lysozyme and its mutants indicate that even small changes in the amino acid sequence alter considerably the internal molecular motions and that the internal motions are more organized in the native enzyme than in the mutants.
R
R
Laatikainen
J
J
Saarela
K
K
Tuppurainen
T
T
Hassinen
D000818:Animals; D002645:Chickens; D004527:Egg Proteins / Q000737:chemistry* / Q000235:genetics; D009113:Muramidase / Q000737:chemistry* / Q000235:genetics; D009154:Mutation; D013329:Structure-Activity Relationship; D013816:Thermodynamics
D004527:Egg Proteins; D009113:Muramidase