Drug dependence: stress and dysregulation of brain reward pathways.
Kreek
M J
MJ
Laboratory of the Biology of Addictive Diseases, Rockefeller University, New York, NY 10021, USA.
Koob
G F
GF
D000818:Animals; D016739:Behavior, Addictive / Q000209:etiology / Q000503:physiopathology / Q000523:psychology; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D004298:Dopamine / Q000502:physiology; D000431:Ethanol / Q000009:adverse effects; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000503:physiopathology; D013287:Illicit Drugs / Q000009:adverse effects; D008032:Limbic System / Q000187:drug effects; D008959:Models, Neurological; D008960:Models, Psychological; D009042:Motivation; D009294:Narcotics / Q000009:adverse effects; D009434:Neural Pathways / Q000187:drug effects; D018847:Opioid Peptides / Q000502:physiology; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000503:physiopathology; D017981:Receptors, Neurotransmitter / Q000187:drug effects; D012008:Recurrence; D012054:Reinforcement, Psychology; D012651:Self Medication / Q000009:adverse effects / Q000523:psychology; D013315:Stress, Psychological / Q000209:etiology / Q000503:physiopathology / Q000523:psychology; D013375:Substance Withdrawal Syndrome / Q000150:complications / Q000503:physiopathology / Q000523:psychology; D019966:Substance-Related Disorders / Q000209:etiology / Q000503:physiopathology / Q000523:psychology; D013695:Temperance
D013287:Illicit Drugs; D009294:Narcotics; D018847:Opioid Peptides; D017981:Receptors, Neurotransmitter; D000431:Ethanol; D004298:Dopamine