[Classification of cytokine receptor superfamily and signal transduction--structural feature and functional property].
Cytokines are groups of protein mediators that are involved in cell to cell communication and are classified into several distinct families based on their receptor structures. The class I cytokine receptor family includes most of interleukins and colony stimulating factors receptors and shares a conserved extracellular motif with homology to the fibronectin type III domain. While they do not have any intrinsic enzymatic activity, they bind a member of JAK family kinases. The receptors form a homo- or hetero-multimer by cytokine binding and activate the JAKs associated with the receptor. There are some groups of cytokines which exhibit similar functions by sharing the same receptor subunit.
Laboratory of Cellular Biosynthesis, University of Tokyo.
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Tanaka
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Miyajima
D000818:Animals; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D018121:Receptors, Cytokine / Q000737:chemistry / Q000145:classification* / Q000502:physiology; D015398:Signal Transduction
D018121:Receptors, Cytokine; D011505:Protein-Tyrosine Kinases