[Leptin Receptor].
Leptin is a fat cell-derived satiety factor that regulates food intake and energy expenditure. Its effects are mediated by interactions with the leptin receptor (Ob-R) that is alternatively spliced to encode at least five isoforms(a-e), which are distributed in a wide range of tissues including the hypothalamus. Ob-R is a member of cytokine receptors and involves the JAK-STAT signal transduction system. We found Ob-R mutations in Zucker fatty rats and obese Koletsky rats and demonstrated that Ob-R dysfunction brings around hyperphagia and obesity. However we and others have not found any Ob-R mutation in human obese subjects.
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine.
K
K
Takaya
Y
Y
Ogawa
H
H
Masuzaki
N
N
Matsuoka
K
K
Hosoda
K
K
Nakao
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000502:physiology; D015870:Gene Expression; D006801:Humans; D006963:Hyperphagia / Q000209:etiology; D020738:Leptin; D051379:Mice; D009154:Mutation; D009765:Obesity / Q000209:etiology; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011506:Proteins / Q000502:physiology; D051381:Rats; D011924:Rats, Zucker; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin; D015398:Signal Transduction; D015534:Trans-Activators / Q000378:metabolism
D002352:Carrier Proteins; C515448:LEPR protein, human; D020738:Leptin; D011506:Proteins; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin; D015534:Trans-Activators; C515447:leptin receptor, mouse; D011505:Protein-Tyrosine Kinases