[Changes in vascular wall, blood insulin spectrum and hemostasis system in patients with type II diabetes mellitus and relevant correction].
OBJECTIVE
The study of insulin blood spectrum, capillary morphology (by evidence of skin biopsies), antithrombogenic activity of the vascular wall in patients with non-insulin-dependent diabetes mellitus; assessment of possible corrective therapy.


METHODS
65 patients with type II diabetes mellitus (DM) entered the trial. Concentrations of free, bound, immunoreactive insulin (IRI) and C peptide were measured before and 10, 30, 60, 120 min after intravenous injection of glucose. Microcirculatory bed condition was evaluated by the data from skin biopsies. Antithrombogenic characteristics of the vascular wall were investigated at-test.


RESULTS
The tests discovered that DM patients had high IRI and low free insulin in high glucose levels; disorders of hemostasis, active proliferation in the microvessels. In patients with microangiopathy tiklid therapy given for 45 days reduced the speed and degree of platelet aggregation, improved fibrinolysis and clinical course of the disease.


CONCLUSIONS
High level of IRI may be due to emergence of insulin-like substances dissociation of which produces peptides enhancing proliferative processes.
Iudanova
L S
LS
Starosel'tseva
L K
LK
Al'tshuler
M Iu
MIu
D000368:Aged; D001706:Biopsy; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000097:blood; D002196:Capillaries / Q000187:drug effects / Q000473:pathology; D002455:Cell Division; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy / Q000473:pathology; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D007328:Insulin / Q000097:blood* / Q000378:metabolism; D000078790:Insulin Secretion; D008833:Microcirculation; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D012867:Skin / Q000098:blood supply*; D013988:Ticlopidine / Q000627:therapeutic use
D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D010975:Platelet Aggregation Inhibitors; D013988:Ticlopidine