Relation between exploratory activity and immune function in aged mice: a preliminary study.
Previous studies show that fast exploration of a T-shaped maze by mature mice may predict an above average longevity. Since the nervous and the immune systems work in a coordinated fashion, and it seems that these two homeostatic systems both influence organismic aging and suffer a senescent decline, we have performed a comparative study of the above behavioral parameter and different functions of three representative immune cells: lymphocytes, macrophages and natural killer (NK) cells obtained from old (76 +/- 1 weeks of age) female OF1-Swiss mice. At 70 weeks of age the mice were divided into a 'fast' and a 'slow' group, containing 100 and 0%, respectively, of animals able to explore the 50 cm-long first arm of the maze in 20 s or less. At 76 +/- 1 weeks of age the animals were sacrificed, the peritoneal cell suspensions were obtained and the immune organs (axillary nodes, spleen and thymus) were isolated. The following leukocyte functions were studied in peritoneal macrophages: adherence to substrate, mobility (spontaneous and chemotaxis), ingestion of particles and superoxide anion production whereas mobility, lymphoproliferative response to the mitogen Con A and NK activity were studied in the immune-organ leukocyte suspensions. The results show that the aged fast mice have better immune functions than the aged slow mice.
De la Fuente
M
M
Department of Animal Physiology, Faculty of Biological Sciences, Complutense University, Madrid, Spain. mondelaf@eucmax.sim.ucm.es
Miñano
M
M
Manuel Victor
V
V
Del Rio
M
M
Ferrández
M D
MD
Díez
A
A
Miquel
J
J
D000375:Aging / Q000276:immunology / Q000502:physiology*; D000818:Animals; D005260:Female; D007694:Killer Cells, Natural / Q000502:physiology*; D017737:Macrophages, Peritoneal / Q000502:physiology*; D051379:Mice; D013481:Superoxides / Q000378:metabolism
D013481:Superoxides