title: The value of screening for Down's syndrome in a socioeconomically deprived area with a high ethnic population.
abstract: OBJECTIVE
  To assess the utility of biochemical antenatal screening for Down's syndrome in a socioeconomically deprived area with a high proportion of Asian women from the Indian Subcontinent.
  
  
  METHODS
  Audit of Down's syndrome biochemical screening service over a four-year period.
  
  
  METHODS
  Teaching hospital and community antenatal clinic in inner city Birmingham.
  
  
  METHODS
  Women booked between October 1992 and December 1996.
  
  
  METHODS
  Blood for screening was collected between 14 and 21 weeks gestation, alpha-fetoprotein and intact human chorionic gonadotrophin were measured in serum and the risk of Down's syndrome was calculated.
  
  
  METHODS
  Uptakes of screening and amniocentesis, screen positive rate, odds of being affected given a positive result, miscarriages associated with amniocentesis offered following a high risk result, detection rate, number of Down's cases prevented and a cost analysis. Outcome measures were compared between Asians and Caucasians.
  
  
  RESULTS
  Overall 11,974 women (71%) accepted serum screening. The screen positive rate was 8.3% in Asians and 5.0% in Caucasians. The uptake of amniocentesis in women following a high risk result was 54% overall (35% Asian, 67% Caucasian). Nineteen cases of Down's syndrome were identified, of which 13 occurred in women who opted for biochemical screening. The detection rate of the biochemical screening programme was 85% (11/13). Of these 11 cases, six (none of whom were Asian) elected to have an amniocentesis, of whom four thereafter had a termination.
  
  
  CONCLUSIONS
  In this study the public health benefits of screening for Down's syndrome in a socioeconomically deprived area with a high Asian population, were small.
authors.affiliation: Department of Clinical Biochemistry, Birmingham Heartlands Hospital, UK.
authors.forename: C
authors.initials: C
authors.lastname: Ford
authors.forename: A J
authors.initials: AJ
authors.lastname: Moore
authors.forename: P A
authors.initials: PA
authors.lastname: Jordan
authors.forename: W A
authors.initials: WA
authors.lastname: Bartlett
authors.forename: M P
authors.initials: MP
authors.lastname: Wyldes
authors.forename: A F
authors.initials: AF
authors.lastname: Jones
authors.forename: W E
authors.initials: WE
authors.lastname: MacKenzie
mesh_terms: D000649:Amniocentesis / Q000706:statistics & numerical data; D001208:Asia / Q000208:ethnology; D003365:Costs and Cost Analysis; D004314:Down Syndrome / Q000191:economics / Q000208:ethnology / Q000517:prevention & control*; D004739:England / Q000453:epidemiology; D005260:Female; D005865:Gestational Age; D006801:Humans; D008403:Mass Screening / Q000191:economics / Q000592:standards / Q000706:statistics & numerical data*; D008485:Medical Audit; D010342:Patient Acceptance of Health Care; D011204:Poverty Areas; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000191:economics / Q000379:methods / Q000706:statistics & numerical data*