title: Close correlation between telomerase expression and adenomatous polyp progression in multistep colorectal carcinogenesis.
abstract: To investigate the role of telomerase in the multistep colorectal carcinogenesis, we examined telomerase activity in 31 adenomatous polyps and 22 paired cancer-normal mucosa specimens from non-hereditary nonpolyposis colorectal cancer patients. Telomerase activity was detected in 18% of normal mucosa, 16% of small (<1.0 cm) polyps, 20% of intermediate polyps, 71% of large (>2.0 cm) polyps, and 96% of adenocarcinoma samples (P for trend, <0.0001). High-level enzyme activities were seen in none of the normal mucosa, 5% of small polyps, 20% of intermediate polyps, 43% of large polyps, and 73% of adenocarcinoma samples (P for trend, <0.0001). These data indicate telomerase reactivation occurs with adenomatous polyp progression in multistep colorectal carcinogenesis.
authors.affiliation: Department of Colorectal Surgery, Chang Gung Memorial Hospital, Taipei, Taiwan, Republic of China. rptang@ms11.hinet.net
authors.forename: R
authors.initials: R
authors.lastname: Tang
authors.forename: A J
authors.initials: AJ
authors.lastname: Cheng
authors.forename: J Y
authors.initials: JY
authors.lastname: Wang
authors.forename: T C
authors.initials: TC
authors.lastname: Wang
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000201:enzymology* / Q000473:pathology*; D000704:Analysis of Variance; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism*; D019098:Telomerase / Q000378:metabolism*
chemical_list: D009363:Neoplasm Proteins; D019098:Telomerase