Visual hemifield mapping using transcranial magnetic stimulation coregistered with cortical surfaces derived from magnetic resonance images.
The perception of a visual stimulus can be inhibited by occipital transcranial magnetic stimulation. This visual suppression effect has been attributed to disruption in the cortical gray matter of primary visual cortex or in the fiber tracts leading to V1 from the thalamus. However, others have suggested that the visual suppression effect is caused by disruption in secondary visual cortex. Here the authors used a figure-eight coil, which produces a focal magnetic field, and a Quadropulse stimulator to produce visual suppression contralateral to the stimulated hemisphere in five normal volunteer subjects. The authors coregistered the stimulation sites with magnetic resonance images in these same subjects using optical digitization. The stimulation sites were mapped onto the surface of the occipital lobes in three-dimensional reconstructions of the cortical surface to show the distribution of the visual suppression effect. The results were consistent with disruption of secondary visual cortical areas.
Potts
G F
GF
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
Gugino
L D
LD
Leventon
M E
ME
Grimson
W E
WE
Kikinis
R
R
Cote
W
W
Alexander
E
E
Anderson
J E
JE
Ettinger
G J
GJ
Aglio
L S
LS
Shenton
M E
ME
D000328:Adult; D001931:Brain Mapping / Q000379:methods*; D004574:Electromagnetic Fields; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009430:Neural Analyzers / Q000502:physiology; D009433:Neural Inhibition / Q000502:physiology; D009778:Occipital Lobe / Q000033:anatomy & histology / Q000502:physiology*; D010812:Physical Stimulation; D014794:Visual Fields / Q000502:physiology*; D014795:Visual Pathways / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology*