title: Local administration of L-703,081 using a composite polymeric stent reduces platelet deposition in canine coronary arteries.
abstract: We compared the effect on platelet deposition of the glycoprotein IIb/IIIa receptor antagonist L-703,081, administered locally via a drug delivery stent, with that of a standard metal stent in a canine coronary model. There was a significant reduction in platelet deposition using the L-703,081-impregnated stent compared with the bare metal stent. This study demonstrates an alternative route of delivery of GPIIb/IIIa antagonists with potential advantages over systemic administration.
authors.affiliation: Duke University Medical Center, Durham, North Carolina 27710, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Santos
authors.forename: J F
authors.initials: JF
authors.lastname: Tanguay
authors.forename: J J
authors.initials: JJ
authors.lastname: Crowley
authors.forename: K R
authors.initials: KR
authors.lastname: Kruse
authors.forename: D
authors.initials: D
authors.lastname: Sanders-Millare
authors.forename: J P
authors.initials: JP
authors.lastname: Zidar
authors.forename: H R
authors.initials: HR
authors.lastname: Phillips
authors.forename: Y
authors.initials: Y
authors.lastname: Merhi
authors.forename: E
authors.initials: E
authors.lastname: Garcia-Cantu
authors.forename: R
authors.initials: R
authors.lastname: Bonan
authors.forename: G
authors.initials: G
authors.lastname: Côté
authors.forename: R S
authors.initials: RS
authors.lastname: Stack
mesh_terms: D000818:Animals; D001682:Biological Availability; D003326:Coronary Circulation / Q000187:drug effects*; D003331:Coronary Vessels / Q000187:drug effects*; D004285:Dogs; D004343:Drug Implants; D004867:Equipment Design; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000493:pharmacokinetics / Q000494:pharmacology*; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors*; D011091:Polyesters; D015607:Stents; D013329:Structure-Activity Relationship; D013499:Surface Properties
chemical_list: D004343:Drug Implants; D010975:Platelet Aggregation Inhibitors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D011091:Polyesters; C016240:polycaprolactone