title: [Correlation between pyrimidine nucleoside phosphorylase (PyNPase)/platelet-derived endothelial cell growth factor and histological prognostic factor, and influences of 5'-deoxy-5-fluorouridine (5'-DFUR) administration on PyNPase levels. 5'-DFUR Joint Research Group in the Osaka Area for Gastric Cancer].
abstract: OBJECTIVE
  Pyrimidine nucleoside phosphorylase (PyNPase), among which thymidine phosphorylase (dThdPase) exists mainly in human tumor tissues, is an enzyme to convert 5'-deoxy-5-fluorouridine (5'-DFUR) to 5-fluorouracil. Recently, it was reported that dThdPase was identical to platelet-derived endothelial cell growth factor, angiogenetic factor. Therefore, we expect that there is possibility of dThdPase being a prognostic factor.
  
  
  METHODS
  We investigated for a possible correlation between PyNPase activities in tumor tissues and prognostic factors of histological findings, examined the influences of preoperative oral 5'-DFUR administration to PyNPase levels and investigated for a correlation between HPLC methods and ELISA methods in patients with gastric cancer.
  
  
  RESULTS
  Higher levels of PyNPase were observed in patients with advanced t,n,v, and ly factors. PyNPase levels decreased by 5'-DFUR in patients with differentiated cases. A high correlation was found between HPLC and ELISA methods.
  
  
  CONCLUSIONS
  This study suggests that we must investigate possibility of PyNPase being a prognostic factor in more detail.
authors.affiliation: Dept. of Surgery, Osaka Kousei Nenkin Hospital.
authors.forename: Y
authors.initials: Y
authors.lastname: Yamasaki
authors.forename: K
authors.initials: K
authors.lastname: Kuwata
authors.forename: K
authors.initials: K
authors.lastname: Hioki
authors.forename: M
authors.initials: M
authors.lastname: Sowa
authors.forename: K
authors.initials: K
authors.lastname: Hirakawa
authors.forename: K
authors.initials: K
authors.lastname: Okajima
authors.forename: H
authors.initials: H
authors.lastname: Isozaki
authors.forename: T
authors.initials: T
authors.lastname: Iwanaga
authors.forename: H
authors.initials: H
authors.lastname: Furukawa
authors.forename: H
authors.initials: H
authors.lastname: Nakano
authors.forename: A
authors.initials: A
authors.lastname: Watanabe
authors.forename: M
authors.initials: M
authors.lastname: Takami
authors.forename: Y
authors.initials: Y
authors.lastname: Tsukahara
authors.forename: S
authors.initials: S
authors.lastname: Matsunaga
authors.forename: N
authors.initials: N
authors.lastname: Kikkawa
authors.forename: T
authors.initials: T
authors.lastname: Gotoh
authors.forename: H
authors.initials: H
authors.lastname: Tokuda
authors.forename: S
authors.initials: S
authors.lastname: Takahashi
authors.forename: M
authors.initials: M
authors.lastname: Toyohara
authors.forename: M
authors.initials: M
authors.lastname: Yagi
authors.forename: J
authors.initials: J
authors.lastname: Takebayashi
authors.forename: T
authors.initials: T
authors.lastname: Nakajima
authors.forename: H
authors.initials: H
authors.lastname: Miyazaki
authors.forename: H
authors.initials: H
authors.lastname: Kuwata
authors.forename: H
authors.initials: H
authors.lastname: Nakazato
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002851:Chromatography, High Pressure Liquid; D004797:Enzyme-Linked Immunosorbent Assay; D005467:Floxuridine / Q000008:administration & dosage*; D006801:Humans; D010430:Pentosyltransferases / Q000378:metabolism*; D011379:Prognosis; D057845:Pyrimidine Phosphorylases; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology*; D013939:Thymidine Phosphorylase / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D005467:Floxuridine; D010430:Pentosyltransferases; D057845:Pyrimidine Phosphorylases; D013939:Thymidine Phosphorylase; C025034:doxifluridine