[Susceptibility of beta-hemolytic streptococci to antibiotics and alternative drugs].
Antibiotic susceptibility of the circulating beta-hemolytic streptococci of serogroups A, B, C and G isolated from healthy and sick children and adults within 1987-1996 (more than 900 cultures) was studied. It was shown that the MICs of betalactam antibiotics did not change (within the susceptibility levels) with respect to the serogroup A, C and G streptococci. The number of the strains resistant to erythromycin and lincomycin increased the same as the frequency of the strains simultaneously resistant to chloramphenicol, tetracycline and gentamicin. Tomicid and solkarmon, drugs alternative to antibiotics, were found to be active against the above streptococci groups and efficient in the treatment and prophylaxis of streptococcoses. A suggestion that betalactams are not safe in the treatment of the toxic shock syndrome due to the group A streptococci is discussed.
Kondrakova
O A
OA
I.M. Sechenov Moscow Medical Academy, NIF Ultrasan, Moscow.
Eshchina
A S
AS
Dmitrieva
N F
NF
Briko
N I
NI
Babin
V N
VN
D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000627:therapeutic use*; D001430:Bacteriocins; D002648:Child; D002702:Chloramphenicol Resistance; D015169:Colony Count, Microbial; D004352:Drug Resistance, Microbial; D005232:Fatty Acids, Volatile / Q000008:administration & dosage / Q000627:therapeutic use*; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000517:prevention & control; D012541:Scarlet Fever / Q000517:prevention & control; D013290:Streptococcal Infections / Q000517:prevention & control*; D013291:Streptococcus / Q000187:drug effects* / Q000302:isolation & purification; D013753:Tetracycline Resistance; D014069:Tonsillitis / Q000517:prevention & control; D018440:beta-Lactam Resistance
D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D001430:Bacteriocins; D005232:Fatty Acids, Volatile; D005839:Gentamicins; C026129:tomicide