title: Use of the selective serotonin reuptake inhibitor citalopram in a possible animal analogue of obsessive-compulsive disorder.
abstract: Canine acral lick dermatitis (ALD) has been suggested as an animal analogue of obsessive-compulsive disorder (OCD). A series of dogs with ALD or similar conditions were treated with citalopram, the most selective of the selective serotonin reuptake inhibitors. Six of nine (66.7%) dogs showed significant improvement. Given the apparent efficacy of citalopram in the treatment of OCD and related disorders, these data provide further evidence that ALD is a useful animal analogue of OCD.
authors.affiliation: Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa.
authors.forename: D J
authors.initials: DJ
authors.lastname: Stein
authors.forename: I
authors.initials: I
authors.lastname: Mendelsohn
authors.forename: F
authors.initials: F
authors.lastname: Potocnik
authors.forename: J
authors.initials: J
authors.lastname: Van Kradenberg
authors.forename: C
authors.initials: C
authors.lastname: Wessels
mesh_terms: D000818:Animals; D015283:Citalopram / Q000494:pharmacology / Q000627:therapeutic use*; D003872:Dermatitis / Q000209:etiology / Q000517:prevention & control; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D005500:Follow-Up Studies; D006120:Grooming / Q000187:drug effects; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000150:complications / Q000188:drug therapy*; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D015283:Citalopram; D017367:Selective Serotonin Reuptake Inhibitors