title: [Changes in the levels of prostate-specific antigen and its molecular forms with alpha 1-antichymotrypsin in patients with benign prostatic hyperplasia].
abstract: Analysis of the changes in the levels of total prostatic specific antigen (t-PSA) in patients with benign prostatic hyperplasia (BPH) shows that the patient's age, size of the prostatic gland and chronic bacterial prostatitis influence the levels of t-PSA but have no effect on the levels of PSA-ACT. The relationship between the levels of t-PSA and age in BPH patients is explained by growing mass of benign hyperplasia causing mechanical load on the intact prostatic tissue. The maximal concentration of t-PSA of 8.7 +/- 1.22 ng/ml was observed in BPH patients at the age of 61-70 years. BPH stages, chronic pyelonephritis, chronic non-bacterial prostatitis, chronic renal failure are not essential for t-PSA and PSA-ACT and can be neglected in interpretation of t-PSA values in BPH patients.
authors.forename: M E
authors.initials: ME
authors.lastname: Grigor'ev
authors.forename: E B
authors.initials: EB
authors.lastname: Mazo
authors.forename: V P
authors.initials: VP
authors.lastname: Chekhonin
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D006801:Humans; D007124:Immunoenzyme Techniques; D007676:Kidney Failure, Chronic / Q000150:complications; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood*; D011470:Prostatic Hyperplasia / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D011472:Prostatitis / Q000150:complications; D011704:Pyelonephritis / Q000150:complications; D015842:Serine Proteinase Inhibitors / Q000097:blood*; D000514:alpha 1-Antichymotrypsin / Q000097:blood*
chemical_list: D015842:Serine Proteinase Inhibitors; D000514:alpha 1-Antichymotrypsin; D017430:Prostate-Specific Antigen