[Current methods for assessing mucociliary transport disorders in the diagnosis of chronic rhinosinusitis].
Mucociliary transport of nasal and paranasal sinus mucosa was assessed in 30 healthy subjects and 40 patients with chronic purulent rhinosinusitis. Clinical, biophysical, mathematical, histological and electron microscopic methods were employed. Biophysical investigation comprised life-time TV microscopy of the specimens. Mucociliary transport investigation and sparing sampling of the ciliary epithelium from mucosa surface of the nose and paranasal sinuses were performed by means of a special apparatus. The computer program modelled vibration of the cilia and estimated their movements (total waving frequency, duration of the impact and raising phases, their correlation). The study discovered prominent structural and functional impairment of the mucociliary system manifesting as ciliary dyskinesia and epithelium converting into the stratified squamous one.
Zakharova
G P
GP
Shabalin
V V
VV
Lantsov
A A
AA
D000328:Adult; D002908:Chronic Disease; D002925:Ciliary Motility Disorders / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D008722:Methods; D009079:Mucociliary Clearance; D012220:Rhinitis / Q000175:diagnosis* / Q000503:physiopathology; D012852:Sinusitis / Q000175:diagnosis* / Q000503:physiopathology; D013997:Time Factors