FUSE-binding protein is developmentally regulated and is highly expressed in mouse and chicken embryonic brain.
GAP-43 modulates axon guidance and neuronal plasticity. In vitro, FUSE-binding protein (FBP) binds to a segment of GAP-43 mRNA which regulates the stability of the transcript. FBP has also been shown to bind to a c-myc cis element and regulate transcription. In the current work, analysis of RNA and protein expression indicated that FBP is expressed in a distinct spatial temporal pattern during embryonic development. Expression was particularly high in the brain. In the adult, expression was not detected in most tissues but was still prominent in the brain and teste. This finding is consistent with a dual role of the protein as a single-strand polynucleotide-binding protein.
Wang
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Department of Cell Biology and Anatomy, University Nebraska Medical Center, Omaha 68198-6395, USA.
Avigan
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Norgren
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D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000196:embryology / Q000378:metabolism*; D002352:Carrier Proteins / Q000235:genetics*; D002642:Chick Embryo; D004622:Embryo, Mammalian / Q000378:metabolism; D019922:GAP-43 Protein / Q000235:genetics; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009928:Organ Specificity; D051381:Rats; D017386:Sequence Homology, Amino Acid
D002352:Carrier Proteins; D019922:GAP-43 Protein; D009419:Nerve Tissue Proteins