title: Diffusion-weighted magnetic resonance imaging in acute stroke.
abstract: OBJECTIVE
  Diffusion-weighted MRI (DWI) is highly sensitive in detecting early cerebral ischemic changes in acute stroke patients. In this study we compared the sensitivity of DWI with that of conventional MRI techniques. Furthermore, we investigated the prognostic value of the volume of ischemic lesions on DWI scans and of the apparent diffusion coefficient (ADC).
  
  
  METHODS
  We performed DWI, fluid-attenuated inversion recovery, spin-echo T2-weighted MRI, and spin-echo proton density-weighted MRI in 42 patients with acute stroke and 15 control subjects. The volume of ischemic lesions was measured on early (<60 hours after onset) and follow-up MRI scans. Clinical outcome was measured 4 months after onset of symptoms with the National Institutes of Health Stroke Scale, the Barthel Index, and the Rankin Scale.
  
  
  RESULTS
  With DWI, 98% of the ischemic lesions were detected, and with fluid-attenuated inversion recovery, 91% were detected, whereas with early T2-weighted or proton density-weighted scans, only 71% (P=0.002, chi2) and 80% (P=0.02, chi2) of lesions, respectively, were found. Lesion volume on early DWI scans correlated significantly with clinical outcome ratings (P<0.01). In patients with a first-ever stroke, a lesion volume of < or =22 mL on DWI predicted good outcome with a 75% sensitivity and a 100% specificity. The mean ADC of ischemic lesions was 29% lower than the ADC of normal-appearing parts of the brain (P<0.001). The ADC ratio correlated significantly with clinical outcome (P<0.05).
  
  
  CONCLUSIONS
  DWI is a better imaging method than conventional MRI in detecting early ischemic lesions in stroke patients. Lesion size as measured on DWI scans and, to a lesser extent, ADC values are potential parameters for predicting clinical outcome in acute stroke patients.
authors.affiliation: Department of Radiology, University Hospital Utrecht, The Netherlands. K.vanEverdingen@rrn.azu.nl
authors.forename: K J
authors.initials: KJ
authors.lastname: van Everdingen
authors.forename: J
authors.initials: J
authors.lastname: van der Grond
authors.forename: L J
authors.initials: LJ
authors.lastname: Kappelle
authors.forename: L M
authors.initials: LM
authors.lastname: Ramos
authors.forename: W P
authors.initials: WP
authors.lastname: Mali
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000175:diagnosis / Q000401:mortality / Q000628:therapy; D002544:Cerebral Infarction / Q000175:diagnosis / Q000401:mortality / Q000628:therapy; D002561:Cerebrovascular Disorders / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000592:standards*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016896:Treatment Outcome