[Long-term prognostic role of steroid receptors in cancer of the breast].
We screened for the prognostic value of estrogen receptor (ER) and progesterone receptor (PR) through a multicentric study of 2,257 operable breast cancer patients who did not received adjuvant therapy. Three hundred and seven local-regional recurrences, 105 metachronous contralateral breast cancer, 589 metastases and 537 deaths from cancer had been diagnosed with a median follow-up of 8.5 years. A total of 69% of the tumors were ER positive and 54% PR positive. For statistical analysis, 1,665 patients were studied because of complete clinical and biological data. In univariate analysis, ER and PR status were of prognostic value for the metastases-free interval (MFI) and the overall survival (OS). In multivariate analysis (Cox proportional hazard model), only the ER status showed a significant difference between positive and negative groups regarding the MFI and OS. By using Cox regression model with time-dependent covariates, we show that the predictive value of ER status of the primary tumor decreases by approximately 20% per year, losing its significance after 8 years of follow-up. These results show that ER and PR status have a relatively limited predictive value and their major interest remain in the domain of therapeutic decision.
Broët
P
P
Unité de biostatistiques, Institut Curie, Paris, France.
Pichon
M F
MF
Magdelenat
H
H
Delarue
J C
JC
Spyratos
F
F
Basuyau
J P
JP
Saez
S
S
Rallet
A
A
Courrière
P
P
Millon
R
R
Asselain
B
B
D000328:Adult; D001943:Breast Neoplasms / Q000737:chemistry* / Q000401:mortality* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*; D012306:Risk; D016019:Survival Analysis
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone