title: Unpredictable response to vasodilator therapy in primary pulmonary hypertension.
abstract: A 49-year-old man with severe primary pulmonary hypertension unresponsive to multiple vasodilators showed beneficial response to intravenous (i.v.) isoproterenol with significant decrease in the pulmonary vascular resistance and increase in the cardiac output. However, the patient became dependent on i.v. isoproterenol and eventually died suddenly following an episode of bradyarrhythmia. Autopsy confirmed severe primary pulmonary hypertension. As the response to vasodilator therapy can be unpredictable in PPH, sequential hemodynamic evaluation of drugs is necessary for finding an optimal therapeutic agent.
authors.affiliation: VA Medical Center, University of South Florida College of Medicine, Bay Pines 33744, USA.
authors.forename: M I
authors.initials: MI
authors.lastname: Schmiedt
authors.forename: U R
authors.initials: UR
authors.lastname: Shettigar
authors.forename: M
authors.initials: M
authors.lastname: Siddique
authors.forename: G
authors.initials: G
authors.lastname: Barbier
authors.forename: M
authors.initials: M
authors.lastname: Bialow
authors.forename: S
authors.initials: S
authors.lastname: Carranza
mesh_terms: D001919:Bradycardia / Q000150:complications; D017809:Fatal Outcome; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D007262:Infusions, Intravenous; D007545:Isoproterenol / Q000627:therapeutic use*; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D014665:Vasodilator Agents; D007545:Isoproterenol