Potentiation of N-methyl-D-aspartate currents by isoproterenol in the acutely dissociated rat amygdalar neurons.
Whole-cell patch-clamp recordings in the acutely dissociated amygdalar neurons were performed to investigate the effect of isoproterenol (Iso) on NMDA currents. Bath application of Iso selectively enhanced the NMDA currents without affecting the AMPA currents. Iso potentiated the NMDA currents to the same extent at various holding potentials and the reversal potential for the NMDA response was not altered. These results suggest that adrenergic innvervations in this area may play an important role in synaptic plasticity.
Huang
C C
CC
Department of Pharmacology, College of Medicine, National Cheng-Kung University, Tainan City, Taiwan.
Lin
C H
CH
Gean
P W
PW
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D004357:Drug Synergism; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D016202:N-Methylaspartate / Q000494:pharmacology*; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D018408:Patch-Clamp Techniques; D051381:Rats; D017207:Rats, Sprague-Dawley; D018091:Receptors, AMPA / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects / Q000502:physiology*
D018091:Receptors, AMPA; D016194:Receptors, N-Methyl-D-Aspartate; D016202:N-Methylaspartate; D007545:Isoproterenol