Tolyporphins J and K, two further porphinoid metabolites from the cyanobacterium Tolypothrix nodosa.
Two new porphinoids, tolyporphins J (1) and K (2), have been isolated from the terrestrial cyanobacterium, Tolypothrix nodosa (HT-58-2) and identified by NMR and mass spectral analysis. The activities of tolyporphins J and K in cell sensitization and drug accumulation assays for multidrug resistance (MDR) reversal were compared with those of tolyporphin A. Unusual NMR spectroscopic shifts were observed for tolyporphin J (1) in CDCl3.
Prinsep
M R
MR
Department of Chemistry, University of Waikato, Private Bag 3105, Hamilton, New Zealand. michele@waikato.ac.nz
Patterson
G M
GM
Larsen
L K
LK
Smith
C D
CD
D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D000458:Cyanobacteria / Q000737:chemistry*; D018432:Drug Resistance, Multiple; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D011166:Porphyrins / Q000302:isolation & purification / Q000494:pharmacology*; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured; D014747:Vinblastine / Q000378:metabolism
D000903:Antibiotics, Antineoplastic; D011166:Porphyrins; C115541:tolyporphin J; C115542:tolyporphin K; D014747:Vinblastine