title: Listeria monocytogenes meningitis in a penicillin-allergic paediatric renal transplant patient.
abstract: Currently in many centres the extended spectrum cephalosporins (e.g. cefotaxime and ceftriaxone) are being used empirically for patients with suspected bacterial meningitis. We present a case of meningitis in a penicillin allergic paediatric renal transplant patient from whose cerebrospinal fluid (CSF) Listeria monocytogenes was cultured, despite four days of cefotaxime therapy. The patient was successfully treated with meropenem but required neuro-endoscopic intervention for hydrocephalus.
authors.affiliation: Department of Microbiology, Queens Medical Centre, Nottingham, UK.
authors.forename: V C
authors.initials: VC
authors.lastname: Weston
authors.forename: J
authors.initials: J
authors.lastname: Punt
authors.forename: M
authors.initials: M
authors.lastname: Vloebeghs
authors.forename: A R
authors.initials: AR
authors.lastname: Watson
authors.forename: P
authors.initials: P
authors.lastname: Ispahani
mesh_terms: D019980:Amoxicillin-Potassium Clavulanate Combination / Q000009:adverse effects*; D002439:Cefotaxime / Q000627:therapeutic use; D002511:Cephalosporins / Q000627:therapeutic use; D002555:Cerebrospinal Fluid / Q000382:microbiology; D002648:Child; D004342:Drug Hypersensitivity; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D016030:Kidney Transplantation / Q000276:immunology*; D008089:Listeria monocytogenes / Q000302:isolation & purification*; D008584:Meningitis, Listeria / Q000188:drug therapy / Q000382:microbiology*; D000077731:Meropenem; D013845:Thienamycins / Q000097:blood / Q000134:cerebrospinal fluid / Q000627:therapeutic use
chemical_list: D002511:Cephalosporins; D013845:Thienamycins; D019980:Amoxicillin-Potassium Clavulanate Combination; D000077731:Meropenem; D002439:Cefotaxime