title: Recording heart rate and blood pressure in rats during parabolic flight.
abstract: The way in which the cardiovascular system adapts to weightlessness is still under discussion. No data are yet available on the responses of rats during space flight, although this animal is commonly used in simulation studies. We have designed and tested a protocol to study the short term responses of the cardiovascular system to weightlessness during parabolic flight. A telemetry system was used to measure heart rate (HR) and blood pressure. It was possible to collect and record radio-signals without any interference. Microgravity caused a reduction in HR, an increase in mean arterial pressure (MAP, 7%), and a non-significant decrease in central venous pressure (CVP, 13%). The change in CVP was similar to the decrease observed in human space flight. This type of study may also be feasible for longer exposure of rats to microgravity (space flight).
authors.affiliation: Laboratoire de Physiologie de l'Environnement (Groupement d'Intérêt Public de l'Exercice), Faculté de Médecine Grange-Blanche, Lyon, France. somody@rockefeller.univ-lyon1.fr
authors.forename: L
authors.initials: L
authors.lastname: Somody
authors.forename: S
authors.initials: S
authors.lastname: Fagette
authors.forename: J
authors.initials: J
authors.lastname: Frutoso
authors.forename: C
authors.initials: C
authors.lastname: Gharib
authors.forename: G
authors.initials: G
authors.lastname: Gauquelin
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D002496:Central Venous Pressure / Q000502:physiology; D006339:Heart Rate / Q000502:physiology*; D051381:Rats; D013686:Telemetry; D014893:Weightlessness / Q000009:adverse effects*