Protective effect of turmeric (Curcuma longa L.) extract on carbon tetrachloride-induced liver damage in rats.
The protective effect of tumeric extract (TE) in diet on CCl4-treated rats was studied. Rats were divided into 5 groups: (1) untreated, (2) CCl4 treated, (3) pre-TE for 2 weeks followed by CCl4, (4) TE + CCl4 given concurrently and (5) 5% TE as positive control. The serum levels of bilirubin, cholesterol, aspartate aminotransferase, (AST), alanine amino transferase (AST), (ALT) and alkaline phosphatase were estimated after 1, 2 and 3 months. CCl4 caused a maximum increase (2-3-fold in all the above parameters. As compared to CCl4 group, a short pre-treatment of TE showed reduction in cholesterol, bilirubin, AST, ALT and alkaline phosphatase activity whereas concurrent treatment of TE + CCl4 reduced to a greater extent the levels of all parameters except ALT. To conclude, concurrent treatment of TE gave significant protection against CCl4 though the values did not reach the normal levels.
Deshpande
U R
UR
Radiation Medicine Centre (BARC), Bombay, India.
Gadre
S G
SG
Raste
A S
AS
Pillai
D
D
Bhide
S V
SV
Samuel
A M
AM
D000818:Animals; D001663:Bilirubin / Q000097:blood; D002252:Carbon Tetrachloride Poisoning / Q000628:therapy*; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000201:enzymology / Q000628:therapy*; D030024:Curcuma; D008297:Male; D010936:Plant Extracts; D051381:Rats; D017208:Rats, Wistar
D010936:Plant Extracts; C012596:turmeric extract; D001663:Bilirubin