Clinical benchmark for healing of chronic venous ulcers. Venous Ulcer Study Collaborators.
BACKGROUND
To determine the results of standardized ulcer treatment regimes and effects of the oral thromboxane A2 antagonist Ifetroban (250 mg daily) on healing of chronic lower-extremity venous stasis ulcers.


METHODS
In a prospective, randomized, double blind, placebo-controlled multicenter study, 165 patients were randomized to Ifetroban (n = 83) versus placebo (n = 82) for a period of 12 weeks. Both groups were treated with sustained graduated compression and hydrocolloid. Ulcer size was measured weekly by tracings and computerized planimetry. A total of 150 patients completed the study.


RESULTS
Complete ulcer healing was achieved after 12 weeks in 55% of patients receiving Ifetroban and in 54% of those taking a placebo with no significant differences; 84% of ulcers in both groups achieved greater than 50% area reduction in size.


CONCLUSIONS
These results are likely to be useful as a benchmark for comparison with other treatment protocols concerning the care of chronic lower-extremity stasis ulcers.
Lyon
R T
RT
Division of Vascular Surgery, Montefiore Medical Center, and the Albert Einstein College of Medicine, New York, New York, USA.
Veith
F J
FJ
Bolton
L
L
Machado
F
F
D000328:Adult; D000368:Aged; D001458:Bandages; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000008:administration & dosage / Q000627:therapeutic use*; D003102:Colloids / Q000008:administration & dosage; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010080:Oxazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D010919:Placebos; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D011446:Prospective Studies; D013997:Time Factors; D014647:Varicose Ulcer / Q000175:diagnosis / Q000188:drug therapy*
D019086:Bridged Bicyclo Compounds, Heterocyclic; D003102:Colloids; D010080:Oxazoles; D010919:Placebos; D010975:Platelet Aggregation Inhibitors; C078904:ifetroban