title: Pulmonary function after one-lung ventilation in newborns: the basis for neonatal thoracoscopy.
abstract: BACKGROUND
  To maintain good exposure during major video-assisted thoracic surgery it is necessary to deflate completely the ipsilateral lung. However, little is known about the effects of one-lung ventilation (OLV) on pulmonary function in newborn patients.
  
  
  METHODS
  Ten neonatal domestic pigs with a mean age of 6+/-0.6 days were intubated and ventilated in pressure-controlled mode (inspired oxygen fraction=1.0). One-lung ventilation was maintained for 120 minutes. Serial measurements of hemodynamics and gas exchange were done before, during, and until 90 minutes after OLV. Pulmonary function testing was performed before and after OLV for each lung separately.
  
  
  RESULTS
  With the inspired oxygen fraction set at 1.0, arterial oxygen saturation remained stable at 100% during OLV. Venous admixture and alveolar-arterial oxygen tension gradient increased slightly from the baseline value of 2.6% +/-0.3% to 3.8%+/-0.3% during OLV (mean+/-standard error of the mean; p=0.02), and from 358+/-28 to 407+/-18 mm Hg (not significant), respectively. Both values returned to baseline during the subsequent ventilation of both lungs. Static compliance and resistance of the ventilated lung did not change. Compliance of the collapsed lung decreased after reexpansion from 0.42+/-0.07 to 0.29+/-0.06 mL x cm H2O(-1) x kg(-1), p=0.008). Resistance remained unchanged (0.22+/-0.02 versus 0.25+/-0.05 cm H2O x L(-1) x s(-1); not significant).
  
  
  CONCLUSIONS
  There were only minor effects on pulmonary function during and after OLV in the neonatal piglet. Alterations in gas exchange during OLV were minimal. Prolonged collapse of the lung with subsequent reexpansion was associated with a slight decrease in compliance, indicating some mild lung injury.
authors.affiliation: Department of Pediatric Surgery, University Children's Hospital, Bern, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Tönz
authors.forename: D
authors.initials: D
authors.lastname: Bachmann
authors.forename: D
authors.initials: D
authors.lastname: Mettler
authors.forename: G
authors.initials: G
authors.lastname: Kaiser
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D006439:Hemodynamics; D008168:Lung / Q000502:physiology*; D008170:Lung Compliance; D011659:Pulmonary Gas Exchange; D012121:Respiration, Artificial / Q000379:methods*; D013552:Swine; D013906:Thoracoscopy; D013997:Time Factors