title: Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3, 5-difluoro-6-[3-(4, 5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylgl y cine (ZK-807834): a potent, selective, and orally active inhibitor of the blood coagulation enzyme factor Xa.
authors.affiliation: Discovery Research, Berlex Biosciences, 15049 San Pablo Avenue, P.O. Box 4099, Richmond, California 94804-0099, USA.
authors.forename: G B
authors.initials: GB
authors.lastname: Phillips
authors.forename: B O
authors.initials: BO
authors.lastname: Buckman
authors.forename: D D
authors.initials: DD
authors.lastname: Davey
authors.forename: K A
authors.initials: KA
authors.lastname: Eagen
authors.forename: W J
authors.initials: WJ
authors.lastname: Guilford
authors.forename: J
authors.initials: J
authors.lastname: Hinchman
authors.forename: E
authors.initials: E
authors.lastname: Ho
authors.forename: S
authors.initials: S
authors.lastname: Koovakkat
authors.forename: A
authors.initials: A
authors.lastname: Liang
authors.forename: D R
authors.initials: DR
authors.lastname: Light
authors.forename: R
authors.initials: R
authors.lastname: Mohan
authors.forename: H P
authors.initials: HP
authors.lastname: Ng
authors.forename: J M
authors.initials: JM
authors.lastname: Post
authors.forename: K J
authors.initials: KJ
authors.lastname: Shaw
authors.forename: D
authors.initials: D
authors.lastname: Smith
authors.forename: B
authors.initials: B
authors.lastname: Subramanyam
authors.forename: M E
authors.initials: ME
authors.lastname: Sullivan
authors.forename: L
authors.initials: L
authors.lastname: Trinh
authors.forename: R
authors.initials: R
authors.lastname: Vergona
authors.forename: J
authors.initials: J
authors.lastname: Walters
authors.forename: K
authors.initials: K
authors.lastname: White
authors.forename: M
authors.initials: M
authors.lastname: Whitlow
authors.forename: S
authors.initials: S
authors.lastname: Wu
authors.forename: W
authors.initials: W
authors.lastname: Xu
authors.forename: M M
authors.initials: MM
authors.lastname: Morrissey
mesh_terms: D000284:Administration, Oral; D000578:Amidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D000818:Animals; D000925:Anticoagulants / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D001597:Benzylidene Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D001665:Binding Sites; D001682:Biological Availability; D002417:Cattle; D018360:Crystallography, X-Ray; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D065427:Factor Xa Inhibitors; D006801:Humans; D007275:Injections, Intravenous; D008252:Macaca fascicularis; D008958:Models, Molecular; D008968:Molecular Conformation; D010215:Papio; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D015842:Serine Proteinase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013917:Thrombin / Q000037:antagonists & inhibitors; D014361:Trypsin Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D000578:Amidines; D000925:Anticoagulants; D001597:Benzylidene Compounds; D065427:Factor Xa Inhibitors; D011725:Pyridines; D015842:Serine Proteinase Inhibitors; D014361:Trypsin Inhibitors; C114591:ZK 805412; C114592:Fidexaban; D013917:Thrombin