title: Sample size and power calculations for comparing two independent proportions in a 'negative' trial.
abstract: Statistical methods for evaluating the adequacy of sample size and power cater mainly to the testing for treatment difference in a 'positive' trial. In biomedical research, the trial can sometimes be postulated as 'negative' to demonstrate that the different treatment groups are statistically equivalent. Herein we describe a computer program to determine the adequacy of sample size and power for comparing two independent proportions in a 'negative' trial. The program is written in MicroSoft QuickBasic Version 4.5, and its executable file is suitable for use as a stand-alone program on a microcomputer.
authors.affiliation: National Medical Research Council, Clinical Trials and Epidemiology Research Unit, Singapore, Singapore. taibe@cteru.gov.sg
authors.forename: B C
authors.initials: BC
authors.lastname: Tai
authors.forename: J
authors.initials: J
authors.lastname: Lee
mesh_terms: D002986:Clinical Trials as Topic / Q000379:methods*; D008432:Mathematical Computing; D018401:Sample Size; D013223:Statistics as Topic