The effect of triiodothyronine on cell oxidative capacity in regenerating rat liver.
The recovery of total DNA content and recovery of total cytochrome c oxidase activity in the rat liver after partial hepatectomy is accelerated by triiodothyronine applied in three doses, two before and one immediately after liver resection. Triiodothyronine-treated animals already have higher cytochrome c oxidase activity before resection. The recovery of the tissue oxidative capacity after partial hepatectomy is more rapid in triiodothyronine-treated animals. These data indicate that hormonal activation of the liver regeneration process is involved.
Svátková
R
R
Department of Physiology, Medical Faculty, Charles University, Hradec Králové, Czech Republic.
Cervinková
Z
Z
Kalous
M
M
Rauchová
H
H
Drahota
Z
Z
D000818:Animals; D004247:DNA / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000378:metabolism; D004734:Energy Metabolism; D006498:Hepatectomy; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D008115:Liver Regeneration; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats; D017208:Rats, Wistar; D014284:Triiodothyronine / Q000494:pharmacology*
D014284:Triiodothyronine; D004247:DNA; D003576:Electron Transport Complex IV