title: The G-protein betagamma complex.
abstract: The vast majority of signalling pathways in mammalian cells are mediated by heterotrimeric (alpha betagamma) G proteins. Reviewed here is regulation of signal transduction by the betagamma complex at different protein interfaces: subunit-subunit, receptor-G protein and G protein-effector. The role of diverse beta and gamma subunit types in achieving specificity in signalling and potentially unidentified functions for these subunits also are discussed.
authors.affiliation: Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA. gautam@morpheus.wustl.edu
authors.forename: N
authors.initials: N
authors.lastname: Gautam
authors.forename: G B
authors.initials: GB
authors.lastname: Downes
authors.forename: K
authors.initials: K
authors.lastname: Yan
authors.forename: O
authors.initials: O
authors.lastname: Kisselev
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D019204:GTP-Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D008969:Molecular Sequence Data; D011487:Protein Conformation; D011956:Receptors, Cell Surface / Q000378:metabolism
chemical_list: D011956:Receptors, Cell Surface; D019204:GTP-Binding Proteins