Local administration of L-703,081 using a composite polymeric stent reduces platelet deposition in canine coronary arteries.
We compared the effect on platelet deposition of the glycoprotein IIb/IIIa receptor antagonist L-703,081, administered locally via a drug delivery stent, with that of a standard metal stent in a canine coronary model. There was a significant reduction in platelet deposition using the L-703,081-impregnated stent compared with the bare metal stent. This study demonstrates an alternative route of delivery of GPIIb/IIIa antagonists with potential advantages over systemic administration.
Santos
R M
RM
Duke University Medical Center, Durham, North Carolina 27710, USA.
Tanguay
J F
JF
Crowley
J J
JJ
Kruse
K R
KR
Sanders-Millare
D
D
Zidar
J P
JP
Phillips
H R
HR
Merhi
Y
Y
Garcia-Cantu
E
E
Bonan
R
R
Côté
G
G
Stack
R S
RS
D000818:Animals; D001682:Biological Availability; D003326:Coronary Circulation / Q000187:drug effects*; D003331:Coronary Vessels / Q000187:drug effects*; D004285:Dogs; D004343:Drug Implants; D004867:Equipment Design; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000493:pharmacokinetics / Q000494:pharmacology*; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors*; D011091:Polyesters; D015607:Stents; D013329:Structure-Activity Relationship; D013499:Surface Properties
D004343:Drug Implants; D010975:Platelet Aggregation Inhibitors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D011091:Polyesters; C016240:polycaprolactone