title: The papillomavirus E6 proteins.
abstract: Specific types of human papillomaviruses (HPV) are strongly associated with the development of cervical cancer. The E6 gene from cancer-related HPVs has exhibited functions in tumorigenesis, regulation of transcription, telomerase, and apoptosis. Cancer-related HPVs E6 proteins bind the tumor suppressor p53 and promotes its degradation through an ubiquitin-dependent pathway. Several additional cellular E6-binding proteins have recently been identified and implicated in playing roles in p53-independent functions of E6.
authors.affiliation: Department of Dermatology, New England Medical Center, Boston, MA, USA.
authors.forename: L
authors.initials: L
authors.lastname: Rapp
authors.forename: J J
authors.initials: JJ
authors.lastname: Chen
mesh_terms: D017209:Apoptosis / Q000502:physiology*; D001483:Base Sequence; D002472:Cell Transformation, Viral; D006801:Humans; D008969:Molecular Sequence Data; D009856:Oncogene Proteins, Viral / Q000235:genetics / Q000502:physiology*; D050725:Papillomavirus E7 Proteins; D012097:Repressor Proteins; D019098:Telomerase / Q000378:metabolism; D015533:Transcriptional Activation; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: C068651:E6 protein, Human papillomavirus type 16; D009856:Oncogene Proteins, Viral; D050725:Papillomavirus E7 Proteins; D012097:Repressor Proteins; D016159:Tumor Suppressor Protein p53; C075621:oncogene protein E7, Bovine papillomavirus type 1; C059731:oncogene protein E7, Human papillomavirus type 16; D019098:Telomerase