title: Entropy maps characterize drug effects on brain dynamics in Alzheimer's disease.
abstract: Non-linear quantifiers of brain electrical dynamics (entropy maps computed from the degradation of temporal forecasting of EEG signals) were studied in relation to drug treatment of Alzheimer's disease. A placebo condition was compared to three drug doses (50, 100 and 200 mg). A significant general effect of the drug was found when compared to placebo and specific contrasts between placebo and each of the three drug doses only reveal a significant entropy increase for the highest dose. These effects were localized bilaterally in fronto-temporal areas and support changes in the dynamics of the cerebral structures involved in memory processes.
authors.affiliation: Unité de Neurosciences Cognitives and Imagerie Cérébrale, LENA (CNRS UPR 640), Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Pezard
authors.forename: J
authors.initials: J
authors.lastname: Martinerie
authors.forename: F J
authors.initials: FJ
authors.lastname: Varela
authors.forename: F
authors.initials: F
authors.lastname: Bouchet
authors.forename: D
authors.initials: D
authors.lastname: Guez
authors.forename: C
authors.initials: C
authors.lastname: Derouesné
authors.forename: B
authors.initials: B
authors.lastname: Renault
mesh_terms: D000161:Acoustic Stimulation; D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000503:physiopathology*; D001921:Brain / Q000187:drug effects / Q000503:physiopathology*; D001931:Brain Mapping; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography / Q000187:drug effects*; D019277:Entropy; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D010919:Placebos
chemical_list: D010919:Placebos