title: [The arteriolymphatic administration of antibiotics in treating patients with suppurative-inflammatory diseases of the abdominal cavity organs].
abstract: Experimental study of pharmacokinetics of Gentamicin was carried out in 23 dogs. Three different modes of its intralymphatic administration were used: intranodular inguinal, lymphotropic retroperineal and arterio-lymphatic. It has been established, that arterio-lymphatic mode of introduction of antibiotics (as well as regional endolymphatic and lymphotropic) warrants high concentration of antibiotics in venous blood and lymph. The peculiarity of arteriolymphatic administration is regional effect of accumulation of the antibiotic in organs and tissues of abdominal cavity of corresponding arterial region. Arteriolymphatic infusions of antibiotics have been introduced into complex of drug treatment of patients with pyogenic and inflammatory disorders of abdominal organs. The clinical testing has revealed high curative effect of this made of antibiotics administration.
authors.forename: V M
authors.initials: VM
authors.lastname: Buianov
authors.forename: K Iu
authors.initials: KIu
authors.lastname: Danilov
authors.forename: S V
authors.initials: SV
authors.lastname: Kharitonov
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D003131:Combined Modality Therapy; D004285:Dogs; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D005839:Gentamicins / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000379:methods; D007272:Injections, Intralymphatic / Q000379:methods; D010538:Peritonitis / Q000188:drug therapy*; D011182:Postoperative Care / Q000379:methods; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins