[Regional chemotherapy in experimental cholangiocarcinoma in pigs].
BACKGROUND
Primary cholangiocarcinoma (PCC) accounts for cca 9% of all carcinomas of the liver and biliary system. Its prognosis of always unfavourable and treatment is difficult.


RESULTS
In 25 pigs strain BU PCC was induced chemically with the aim to test the action of regional chemotherapy on the tumor tissue. For treatment 5-fluorouracil, 5-fluoro-2-deoxyuridine, mitomycin C and doxorubicin was used either as monotherapy or in combinations. During chemotherapy a significant reduction of the tumour or fibrotization occurred, as compared with animals not receiving treatment. The median of survival was prolonged from 51.3 to 210.3 days.


CONCLUSIONS
Regional chemotherapy is a significant constituent of oncological treatment of PCC. Complications of treatment are negligible and the rest for further treatment are encouraging.
Dufek
V
V
I. interní klinika 1. LF UK a VFN, Praha.
Petrtýl
J
J
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001650:Bile Duct Neoplasms / Q000188:drug therapy*; D001653:Bile Ducts, Intrahepatic; D010478:Chemotherapy, Cancer, Regional Perfusion; D018281:Cholangiocarcinoma / Q000188:drug therapy*; D013552:Swine