Preparation and dissolution rate of gliquidone-PVP K30 solid dispersions.
Solid dispersions of gliquidone in PVP K30 were prepared by the solvent method. These dispersions were characterized using X-ray diffraction. In comparison with the drug alone, the physical mixtures and even more the solid dispersions showed an increase in the dissolution rate. Moreover these solid dispersions were stable during storage.
Martnez
P
P
Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Navarra, Pamplona, Spain.
Goñi
M M
MM
Cantera
R G
RG
Martin
C
C
Dios-Viéitez
C
C
Martínez-Ohárriz
C
C
D004355:Drug Stability; D004356:Drug Storage; D007004:Hypoglycemic Agents / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry*; D012995:Solubility; D013453:Sulfonylurea Compounds / Q000737:chemistry*
D007004:Hypoglycemic Agents; D013453:Sulfonylurea Compounds; C010969:gliquidone; D011205:Povidone