title: Arterial hypertension due to occlusion of the adrenal vein in the rat is strain-dependent.
abstract: OBJECTIVE
  To determine whether the development of arterial hypertension due to occlusion of the central adrenal vein in the rat is strain-dependent
  
  
  METHODS
  The experiments were performed on male rats weighing 300-400 g each, of the following strains: Wistar outbred, Wistar Glaxo, Lewis, Wistar-Kyoto (WKY) rats bred for high blood pressure (138 +/- 13.2 mmHg), WKY rats bred without the control of blood pressure (118 +/- 12.9 mmHg) and borderline hypertensive rats (BHR). BHR were the F1 spontaneously hypertensive rat and WKY rat crossbred rats. In order to increase blood flow through the adrenal-renal portal circulation, both central adrenal veins of rats in the experimental group were occluded. The systolic blood pressure was measured indirectly by a photoelectric method.
  
  
  RESULTS
  By the ninth day after surgery systolic blood pressure had increased significantly only in the WKY rats bred for high blood pressure and BHR, reaching maximal values on 12th day for WKY rats bred for high blood pressure (167 +/- 5 mmHg) and on the 18th day for BHR (170 +/- 14 mmHg).
  
  
  CONCLUSIONS
  These data show that the development of arterial hypertension due to augmentation of adrenal blood flow through adrenal-renal portal circulation occurs in rats of strains with a genetic background of hypertension.
authors.affiliation: Department of Human Physiology, Medical University of Warsaw, Poland. abram@amwaw.edu.pl
authors.forename: P
authors.initials: P
authors.lastname: Abramczyk
authors.forename: A
authors.initials: A
authors.lastname: Lisiecka
authors.forename: K
authors.initials: K
authors.lastname: Papierski
authors.forename: R
authors.initials: R
authors.lastname: Ziecina
authors.forename: J
authors.initials: J
authors.lastname: Przybylski
mesh_terms: D000311:Adrenal Glands / Q000098:blood supply*; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D003251:Constriction, Pathologic; D006973:Hypertension / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains / Q000502:physiology*; D013045:Species Specificity; D013599:Systole / Q000502:physiology; D014680:Veins / Q000503:physiopathology