Does age of the host affect growth rates of skeletal malignancies?
Statistical analysis of bone tumor growth rates as a function of age at initiation of radiation-induced skeletal malignancies in our animal colony indicated that the p value for an association between these parameters was <0.05, suggesting a correlation in beagle dogs. The youngest animals appeared to exhibit the most slowly growing tumors, and the trend was toward more rapidly growing tumors with increasing age. Less effective immune systems in older animals were invoked as a possible explanation of this relationship.
Lloyd
R D
RD
University of Utah, Radiobiology Laboratory, Salt Lake City 84112-5860, USA.
Thurman
G B
GB
Taylor
G N
GN
Miller
S C
SC
D000367:Age Factors; D000818:Animals; D001859:Bone Neoplasms / Q000473:pathology / Q000503:physiopathology*; D004285:Dogs; D004307:Dose-Response Relationship, Radiation; D007856:Lead Radioisotopes; D009381:Neoplasms, Radiation-Induced / Q000473:pathology / Q000503:physiopathology*; D011336:Probability; D011883:Radium; D013125:Spinal Neoplasms / Q000473:pathology / Q000503:physiopathology
D007856:Lead Radioisotopes; D011883:Radium