Transcription: activation by cooperating conformations.
The cooperative formation of a higher-order complex between transcription factors NFAT and Fos-Jun is accompanied by conformational changes in both DNA and protein. This allows formation of an extended interface between the proteins, while conserving recognition of the core DNA binding sequences.
Travers
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MRC Laboratory of Molecular Biology, Cambridge, UK.
D004247:DNA / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D011487:Protein Conformation; D014157:Transcription Factors / Q000737:chemistry*; D015533:Transcriptional Activation / Q000502:physiology*
D014157:Transcription Factors; D004247:DNA