title: Coronary bypass flow during use of intraaortic balloon pumping and left ventricular assist device.
abstract: BACKGROUND
  Intraaortic balloon pumping (IABP) and left ventricular assist device (LVAD) are used for left ventricular support when low cardiac output occurs after a coronary bypass operation for serious coronary artery disease. There are hemodynamic differences in blood flow in various kinds of coronary artery bypass grafts, caused by their inherent physiologic characteristics. The hemodynamic effects of left ventricular assistance with IABP and LVAD on blood flow through various coronary artery bypass grafts were investigated.
  
  
  METHODS
  An ascending aorta-coronary bypass graft (ACB), an internal thoracic artery, and a descending aorta-coronary bypass graft were anastomosed to the left anterior descending coronary artery in a canine model. In this experimental model, the blood flow to the same coronary bed in the three types of grafts could be evaluated. Blood flow in the left anterior descending coronary artery through the three types of coronary bypass grafts was studied in this model during or in the absence of ventricular assistance.
  
  
  RESULTS
  In the control study, the systolic blood flow did not differ among the three types of grafts, but the diastolic flow decreased in the following order: with the ACB, the internal thoracic artery, and the descending aorta-coronary bypass graft. The systolic flow during IABP and LVAD was similar to the control flows. Use of IABP increased the diastolic flow by 75.3%+/-12.4% of the control value in the ACB, 37.9%+/-25.0% in the internal thoracic artery, and 21.2%+/-11.4% in the descending aorta-coronary bypass graft. The LVAD increased the diastolic flow by 97.7%+/-18.7% of the control value in the ACB, 64.5%+/-25.7% in the internal thoracic artery, and 63.0%+/-27.9% in the descending aorta-coronary bypass graft. The diastolic blood flows in the left anterior descending coronary artery and the three types of grafts were significantly greater with IABP than the control values, and significantly greater with LVAD than with IABP and the control values. The degrees of increase of diastolic flows in the left anterior descending coronary artery and the ACB with IABP and LVAD were significantly greater than in the arterial grafts (p < 0.01).
  
  
  CONCLUSIONS
  The diastolic flows in the internal thoracic artery and descending aorta-coronary bypass graft increased less than in the native left anterior descending coronary artery and ACB during left ventricular assistance, particularly with IABP. It is important for the selection of tactics for the management of catastrophic status after coronary bypass grafting to consider the hemodynamic characteristics of the graft.
authors.affiliation: Department of Surgery (1), Kanazawa University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tedoriya
authors.forename: M
authors.initials: M
authors.lastname: Kawasuji
authors.forename: N
authors.initials: N
authors.lastname: Sakakibara
authors.forename: H
authors.initials: H
authors.lastname: Takemura
authors.forename: Y
authors.initials: Y
authors.lastname: Watanabe
authors.forename: R
authors.initials: R
authors.lastname: Hetzer
mesh_terms: D000818:Animals; D001026:Coronary Artery Bypass / Q000379:methods*; D003326:Coronary Circulation / Q000502:physiology; D003971:Diastole / Q000502:physiology; D004285:Dogs; D006353:Heart-Assist Devices; D007387:Internal Mammary-Coronary Artery Anastomosis / Q000379:methods; D007423:Intra-Aortic Balloon Pumping; D013599:Systole / Q000502:physiology