title: [A case of severe cytomegalovirus infection after the repair of coarctation of aorta].
abstract: We report a 2-month-old boy without any immuno-compromised diseases, who suffered from the severe cytomegalovirus (CMV) infection after the subclavian flap aortoplasty and pulmonary artery banding for coarctation complex. He underwent the operation at 2 months old and received 2 units of irradiated packed red blood cells before and after the surgery. His postoperative course was uneventful but the interstitial pneumonitis, until he developed watery diarrhea 10 days after the surgery following hepatitis with the marked hepatomegaly 3 weeks after. Since CMV infection was confirmed as the cause of the pneumonitis, enterocolitis and hepatitis, he was initially treated by gamma-globulin with the high CMV titer at a dose of 200 mg/kg/day for 2 days and ganciclovir at a dose of 10 mg/kg/day for 14 days. Because of the persistent CMV infection, he needed two more treatments of ganciclovir at the same dosage and gamma-globulin once a week for 2 months. He finally recovered from severe CMV infection 5 months after the above treatments. In conclusion, the severe CMV infection can occur by blood transfusion even in the surgical case with normal immune system. If one finds pneumonitis, hepatitis or enterocolitis after any type of surgery with history of blood transfusion, CMV infection should be suspected as the cause of these diseases.
authors.affiliation: Department of Cardiovascular Surgery, Nagano Children's Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Takeuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Harada
authors.forename: K
authors.initials: K
authors.lastname: Morishima
authors.forename: K
authors.initials: K
authors.lastname: Ohta
authors.forename: G
authors.initials: G
authors.lastname: Satomi
authors.forename: S
authors.initials: S
authors.lastname: Yasukouchi
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage; D001017:Aortic Coarctation / Q000601:surgery*; D006348:Cardiac Surgical Procedures / Q000379:methods; D003586:Cytomegalovirus Infections / Q000209:etiology* / Q000628:therapy; D017707:Erythrocyte Transfusion; D015774:Ganciclovir / Q000008:administration & dosage; D006801:Humans; D007223:Infant; D008297:Male; D011183:Postoperative Complications / Q000209:etiology* / Q000628:therapy; D005719:gamma-Globulins / Q000008:administration & dosage
chemical_list: D000998:Antiviral Agents; D005719:gamma-Globulins; D015774:Ganciclovir