title: The impact of Gaucher disease and its treatment on quality of life.
abstract: To obtain information about how Gaucher disease and its treatment, specifically enzyme replacement therapy, affect patients' health-related quality of life (HRQoL), we interviewed 16 patients with type I Gaucher disease (range 8-67 years). All but three patients had been receiving enzyme replacement therapy for at least 6 months. The quality of life factors examined for these patients included physical health, social life, emotional health, financial burden, future plans and satisfaction with health care. The results indicated that bone pain and chronic fatigue interfered with school, job and social activities and were the most debilitating symptoms of Gaucher disease. Most patients experienced a significant increase in energy level from therapy and reported significant improvements in quality of life. Most patients did not perceive an effect of Gaucher disease on their overall emotional health, but some patients expressed anxieties about the discomfort, inconvenience and high costs of therapy. We conclude that a measure of HRQoL for Gaucher patients should include a generic core of items supplemented by disease-specific items designed to assess the changes in symptoms and in the occupational, recreational, social and emotional aspects of patients' lives that occur as a result of disease progression and/or management.
authors.affiliation: Emory University Center for Clinical Evaluation Sciences, Decatur, GA 30030, USA.
authors.forename: R P
authors.initials: RP
authors.lastname: Hayes
authors.forename: K A
authors.initials: KA
authors.lastname: Grinzaid
authors.forename: E B
authors.initials: EB
authors.lastname: Duffey
authors.forename: L J
authors.initials: LJ
authors.lastname: Elsas
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D005776:Gaucher Disease / Q000150:complications / Q000523:psychology* / Q000628:therapy*; D005845:Georgia; D005962:Glucosylceramidase / Q000191:economics / Q000627:therapeutic use*; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D008875:Middle Aged; D011594:Psychometrics / Q000379:methods*; D011788:Quality of Life; D015203:Reproducibility of Results
chemical_list: C070292:alglucerase; D005962:Glucosylceramidase