Coexistence of 3 tumors of neural crest origin: neurofibroma, meningioma, and uveal malignant melanoma.
OBJECTIVE
To describe the clinical findings in a patient who developed a neurofibroma, meningioma, and choroidal melanoma.


METHODS
Clinical and histopathological findings of the case are reviewed and presented.


RESULTS
The patient had a right superolateral periorbital neurofibroma, a right sphenoid wing meningioma, and a left choroidal juxtapapillary malignant melanoma. All 3 tumors are derived from neural crest cells.


CONCLUSIONS
To our knowledge, this is the first report of a patient with this combination of 3 neural crest-derived tumors. This case is most appropriately classified as a complex neurocristopathy, a disorder involving the aberrant and pathological proliferation of multiple tissues derived from neural crest cells.
Warwar
R E
RE
Department of Ophthalmology, Wright State University School of Medicine, Dayton, Ohio 45429-3487, USA.
Bullock
J D
JD
Shields
J A
JA
Eagle
R C
RC
D002830:Choroid Neoplasms / Q000473:pathology* / Q000601:surgery; D015353:Eye Enucleation; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008545:Melanoma / Q000473:pathology* / Q000601:surgery; D008577:Meningeal Neoplasms / Q000473:pathology* / Q000601:surgery; D008579:Meningioma / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000601:surgery; D009432:Neural Crest / Q000473:pathology*; D009455:Neurofibroma / Q000473:pathology* / Q000601:surgery; D009918:Orbital Neoplasms / Q000473:pathology* / Q000601:surgery