Role of curdlan sulfate in the production of beta-chemokines and interleukin-16.
The blocking effect of curdlan sulfate (CRDS) on human immunodeficiency virus (HIV) infection has been thought to be related to inhibition of the binding of HIV-1 envelope glycoprotein (gp120) and CD4 molecules. However, recent reports have indicated that blocking the binding of gp120 to CD4 by CRDS only makes a small contribution to the inhibition of HIV-1 infection. We report here that the effect of CRDS on the production of beta-chemokines and cytokines might be important in the inhibition of HIV-1 infection, in addition to interference with the binding of gp120 to CD4+ cells.
Naito
T
T
Department of General Medicine, Juntendo University School of Medicine, Tokyo, Japan.
Takeda-Hirokawa
N
N
Kaneko
H
H
Sekigawa
I
I
Matsumoto
T
T
Hashimoto
H
H
Kaneko
Y
Y
D000998:Antiviral Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D054407:Chemokine CCL4; D019742:Chemokines, CC / Q000276:immunology* / Q000378:metabolism; D005936:Glucans / Q000494:pharmacology*; D015699:HIV Envelope Protein gp120 / Q000187:drug effects* / Q000378:metabolism; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D019410:Interleukin-16 / Q000276:immunology* / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000821:virology; D019402:Macrophage Inflammatory Proteins / Q000276:immunology / Q000378:metabolism; D047071:beta-Glucans
D000998:Antiviral Agents; D054407:Chemokine CCL4; D019742:Chemokines, CC; D005936:Glucans; D015699:HIV Envelope Protein gp120; D019410:Interleukin-16; D019402:Macrophage Inflammatory Proteins; D047071:beta-Glucans; C063130:curdlan sulfate