title: Current concepts in the pathophysiology, evaluation, and diagnosis of compartment syndrome.
abstract: This article reviews present knowledge of the pathophysiology and diagnosis of acute compartment syndromes. Recent results using compression of legs in normal volunteers provide objective data concerning local pressure thresholds for neuromuscular dysfunction in the anterior compartment. Results with this model indicate that a progression of neuromuscular deficits occurs when IMP increases to within 35 to 40 mm Hg of diastolic blood pressure. These findings provide useful information on the diagnosis and compression thresholds for acute compartment syndromes. Time factors are also important, however, and usually are incompletely known in most cases of acute compartment syndrome. Although the slit catheter is a very good technique for monitoring IMP during rest, these catheters and their associated extracorporeal transducer systems are not ideal. Recently developed miniature transducer-tipped catheters and, perhaps, future development of noninvasive techniques may provide accurate recordings of IMP in patients with acute compartment syndromes.
authors.affiliation: NASA Ames Research Center, Moffett Field, California, USA.
authors.forename: A R
authors.initials: AR
authors.lastname: Hargens
authors.forename: S J
authors.initials: SJ
authors.lastname: Mubarak
mesh_terms: D000208:Acute Disease; D003161:Compartment Syndromes / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D003937:Diagnosis, Differential; D006801:Humans; D018482:Muscle, Skeletal / Q000503:physiopathology