Early and long-term effects of chronic low-dose radiation and coenzyme Q diet on the proliferation of rat spleen T cells.
Chronic whole-body irradiation (0.43 cGy/day; total doses 11, 23, and 35 cGy) caused non-monotonous long-term disturbances in rat splenic T lymphocytes proliferation. Immunosuppression observed after chronic exposure had no correlation with the splenic cell number and the decrease in the fluorescence intensity of Hoechst 33258-DNA complex in T lymphocytes. Small, but significant radioprotection was observed with Coenzyme Q diet immediately after irradiation. These results indicate that the changes in T cell immunity, T cell viability, and T cell DNA state after exposure to low dose radiation are not interrelated.
Novoselova
E G
EG
Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow District, Russia.
Semiletova
N V
NV
Makar
V R
VR
Gordon RYa
D000818:Animals; D004032:Diet; D004307:Dose-Response Relationship, Radiation; D008213:Lymphocyte Activation / Q000187:drug effects / Q000528:radiation effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000528:radiation effects; D014451:Ubiquinone / Q000008:administration & dosage / Q000494:pharmacology*; D014916:Whole-Body Irradiation
D014451:Ubiquinone