title: Augmented intrathecal secretion of interferon-gamma in response to Borrelia garinii in neuroborreliosis.
abstract: The Lyme disease agent Borrelia garinii has been suggested to be neurotrop, preferentially affecting the nervous system. We compared the secretion of interferon-gamma in response to outer surface proteins from Borrelia garinii and Borrelia afzelii in 10 patients with neuroborreliosis. In cerebrospinal fluid, stimulation with Borrelia garinii revealed higher numbers of interferon-gamma-secreting cells in all patients, whereas in blood, only five displayed higher numbers. This further strengthens the hypothesis of Borrelia garinii being associated with the development of neuroborreliosis.
authors.affiliation: Department of Neuroscience and Locomotion, Faculty of Health Sciences, University Hospital, Linköping, Sweden. christina.ekerfelt@kfc.liu.se
authors.forename: C
authors.initials: C
authors.lastname: Ekerfelt
authors.forename: J
authors.initials: J
authors.lastname: Ernerudh
authors.forename: P
authors.initials: P
authors.lastname: Forsberg
authors.forename: S
authors.initials: S
authors.lastname: Bergström
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000942:Antigens, Bacterial / Q000134:cerebrospinal fluid; D001898:Borrelia / Q000276:immunology*; D001899:Borrelia Infections / Q000276:immunology*; D002555:Cerebrospinal Fluid / Q000166:cytology / Q000276:immunology / Q000382:microbiology; D002648:Child; D005260:Female; D006801:Humans; D007118:Immunoassay; D007371:Interferon-gamma / Q000134:cerebrospinal fluid* / Q000276:immunology / Q000378:metabolism*; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000276:immunology* / Q000382:microbiology
chemical_list: D000942:Antigens, Bacterial; D007371:Interferon-gamma