Murine and human TSPYL genes: novel members of the TSPY-SET-NAP1L1 family.
Using expressed sequence tag (EST) sequence information, novel genes related to the Y chromosome gene family TSPY were isolated and characterized. Because of a significant homology to TSPY, the novel genes were designated TSPY-Like (TSPYL) and were assigned as new members of the TSPY-SET-NAP1L1 family. A human TSPYL gene was localized on chromosome 6 and a murine Tspyl gene was localized on chromosome 10. Expression of TSPYL was observed in all tissues investigated, as well as early onset during development. Both the human and murine Tspyl homologs lack introns over the entire region so far investigated and are thought to have arisen by an ancient retroposition event. Retroposition of Tspyl genes is supported by the isolation of a murine Tspyl pseudogene on chromosome 12 which also lacks intronic sequences, and by its observed proximity to an R element, a family of dispersed repetitive DNA.
Vogel
T
T
Institut für Humangenetik, Medizinische Hochschule Hannover, Hannover, Germany.
Dittrich
O
O
Mehraein
Y
Y
Dechend
F
F
Schnieders
F
F
Schmidtke
J
J
D000818:Animals; D018797:Cell Cycle Proteins; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6; D017931:DNA Primers; D004268:DNA-Binding Proteins / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007438:Introns; D008297:Male; D051379:Mice / Q000235:genetics*; D005810:Multigene Family; D009687:Nuclear Proteins; D016133:Polymerase Chain Reaction; D011544:Pseudogenes; D017384:Sequence Deletion; D019849:Sex Determination Processes; D051876:Sex-Determining Region Y Protein; D014157:Transcription Factors; D014998:Y Chromosome
D018797:Cell Cycle Proteins; D017931:DNA Primers; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D051876:Sex-Determining Region Y Protein; C497749:TSPY1 protein, human; D014157:Transcription Factors