title: The synthesis, radioiodination and preliminary biological study of the new carboxylic derivatives of dithizone.
abstract: Synthesis, characteristics and radioiodination of the new carboxylic derivatives of dithizone are described in this paper. We have applied the carboxy dithizones for preparation of radioactive compounds by coupling with [131I]-histamine. Preliminary biological studies of the new radiodithizone were done in rats after two different application routs: peripheral i.v. injection and direct injection to splenic artery. Biodistribution of the carboxy dithizone-[131I]-histamine conjugate (i.v. injection) was quite different than that for free [131I]-histamine. However, uptake of activity in pancreas was low (0.81% g-1 of tissue). Direct application of the conjugate to splenic artery resulted in high activity retention in pancreas after 30 and 45 min post injection (respectively 8.8 and 12.4% g-1 of tissue) indicating potential usefulness of the new radiodithizone for in vivo monitoring of pancreas.
authors.affiliation: Drug Institute, Warsaw, Poland.
authors.forename: P
authors.initials: P
authors.lastname: Garnuszek
authors.forename: I
authors.initials: I
authors.lastname: Liciñska
authors.forename: P
authors.initials: P
authors.lastname: Fiedor
authors.forename: A P
authors.initials: AP
authors.lastname: Mazurek
mesh_terms: D000818:Animals; D002264:Carboxylic Acids / Q000493:pharmacokinetics*; D004230:Dithizone / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D006632:Histamine / Q000493:pharmacokinetics; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D051381:Rats; D012974:Sodium Iodide; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: C114761:2,2'-dicarboxydithizone; C114762:4,4'-dicarboxydithizone; D002264:Carboxylic Acids; D007457:Iodine Radioisotopes; D004230:Dithizone; D006632:Histamine; D012974:Sodium Iodide