title: Evidence that an HLA-DQA1-DQB1 haplotype influences susceptibility to childhood common acute lymphoblastic leukaemia in boys provides further support for an infection-related aetiology.
abstract: Comparison of DQA1 and DQB1 alleles in 60 children with common acute lymphoblastic leukaemia (c-ALL) and 78 newborn infant control subjects revealed that male but not female patients had a higher frequency of DQA1*0101/*0104 and DQB1*0501 than appropriate control subjects. The results suggest a male-associated susceptibility haplotype in c-ALL and supports an infectious aetiology.
authors.affiliation: Immunogenetics Laboratory, St Mary's Hospital, Manchester, UK.
authors.forename: G M
authors.initials: GM
authors.lastname: Taylor
authors.forename: S
authors.initials: S
authors.lastname: Dearden
authors.forename: N
authors.initials: N
authors.lastname: Payne
authors.forename: M
authors.initials: M
authors.lastname: Ayres
authors.forename: D A
authors.initials: DA
authors.lastname: Gokhale
authors.forename: J M
authors.initials: JM
authors.lastname: Birch
authors.forename: V
authors.initials: V
authors.lastname: Blair
authors.forename: R F
authors.initials: RF
authors.lastname: Stevens
authors.forename: A M
authors.initials: AM
authors.lastname: Will
authors.forename: O B
authors.initials: OB
authors.lastname: Eden
mesh_terms: D000483:Alleles; D017951:Antigen Presentation; D002648:Child; D002675:Child, Preschool; D003141:Communicable Diseases / Q000276:immunology; D004247:DNA / Q000032:analysis; D004198:Disease Susceptibility / Q000276:immunology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006683:HLA-DQ Antigens / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; D006239:Haplotypes; D006801:Humans; D007223:Infant; D008297:Male; D018807:Polymorphism, Single-Stranded Conformational; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000276:immunology; D012737:Sex Factors
chemical_list: D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; C069050:HLA-DQA1 antigen; C069051:HLA-DQB1 antigen; D004247:DNA