title: High-dose growth hormone therapy in idiopathic short stature.
abstract: This article reviews the available data on the effect of growth hormone (GH) administration on the growth of children with idiopathic short stature. The 1st year growth response appears clearly dose dependent, if the mean values from various clinical trials are combined. Dose dependency has also been shown in prospective trials. The dose dependency of the long-term growth response was less convincing in a large prospective study. The effect on final height cannot be proven with certainty in uncontrolled studies. If all available results from clinical trials are combined, a positive correlation between response and dose appears likely.
authors.affiliation: Department of Paediatrics, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: G A
authors.initials: GA
authors.lastname: Kamp
authors.forename: J M
authors.initials: JM
authors.lastname: Wit
mesh_terms: D001827:Body Height / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D019382:Human Growth Hormone / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011446:Prospective Studies
chemical_list: D019382:Human Growth Hormone