The G-protein betagamma complex.
The vast majority of signalling pathways in mammalian cells are mediated by heterotrimeric (alpha betagamma) G proteins. Reviewed here is regulation of signal transduction by the betagamma complex at different protein interfaces: subunit-subunit, receptor-G protein and G protein-effector. The role of diverse beta and gamma subunit types in achieving specificity in signalling and potentially unidentified functions for these subunits also are discussed.
Gautam
N
N
Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA. gautam@morpheus.wustl.edu
Downes
G B
GB
Yan
K
K
Kisselev
O
O
D000595:Amino Acid Sequence; D000818:Animals; D019204:GTP-Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D008969:Molecular Sequence Data; D011487:Protein Conformation; D011956:Receptors, Cell Surface / Q000378:metabolism
D011956:Receptors, Cell Surface; D019204:GTP-Binding Proteins