Eosinophilic lung disease associated with Candida albicans allergy.
A significant number of cases of chronic eosinophilic pneumonia remain idiopathic in spite of a comprehensive search of associated causes. This study reports a patient with a classical clinical presentation of chronic eosinophilic pneumonia and peripheral blood eosinophilia in whom selective sensitization to Candida albicans was demonstrated. This yeast was present in the bronchoalveolar lavage culture and specific serum immunoglobulin (Ig)E and IgG against C. albicans were found in the patient's serum. Levels of these specific immunoglobulins diminished with corticosteroid treatment and increased coinciding with a new outbreak of symptoms after lowering the dosage of corticosteroids. To the author's knowledge, this is the first case described of chronic eosinophilic pneumonia associated with sensitization to C. albicans. Evaluation of allergy to C. albicans should be performed in chronic eosinophilic pneumonia before labelling cases as idiopathic.
Pacheco
A
A
Pneumology Dept, University of Alcalá, Hospital Ramón y Cajal, Madrid, Spain.
Cuevas
M
M
Carbelo
B
B
Máiz
L
L
Pavón
M J
MJ
Pérez
I
I
Quirce
S
S
D000328:Adult; D000908:Antibodies, Fungal / Q000032:analysis; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology; D002176:Candida albicans / Q000276:immunology*; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000150:complications*; D007073:Immunoglobulin E / Q000032:analysis; D011657:Pulmonary Eosinophilia / Q000175:diagnosis / Q000209:etiology*
D000908:Antibodies, Fungal; D007073:Immunoglobulin E