Residual host cell protein from continuous cell lines. Effect on the safety of protein pharmaceuticals.
The presence of residual host cell proteins in protein pharmaceuticals obtained from continuous mammalian cell lines has been a point of concern. Clinical experience with different biopharmaceuticals shows that residual protein in these highly purified products does not represent a danger to the health of the patients.
Lupker
J H
JH
Sanofi Recherche, Centre de Labège, France.
D000818:Animals; D018929:Cell Culture Techniques / Q000592:standards*; D002460:Cell Line; D006801:Humans; D009857:Oncogenes; D011506:Proteins / Q000235:genetics; D013678:Technology, Pharmaceutical / Q000592:standards*
D011506:Proteins