Histochemical study of the skeletal muscle in children with chronic renal failure in dialysis treatment.
Among the modifications occurring in the uremic organism, in addition to the consequences of dialysis, myopathy and peripheral neuropathy are very significant. Children are particularly affected, as their growth and development are jeopardized. Histochemistry of muscular biopsy was used to study eighteen children with end-stage renal failure under dialysis during a ten-month period. According to our results, the skeletal muscular tissue presented the following types of alterations: atrophy, type grouping, lipidosis, glycogen depletion and mitochondrial proliferation.
do Prado
L B
LB
Departamento de Pediatria da Escola Paulista de Medicina-Universidade Federal de São Paulo (EPM-UNIFESP), Brasil.
do Prado
G F
GF
Oliveira
A S
AS
Schmidt
B
B
Carvalhaes
J T
JT
D000293:Adolescent; D001284:Atrophy; D001706:Biopsy / Q000379:methods; D002648:Child; D002675:Child, Preschool; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism / Q000473:pathology*; D006435:Renal Dialysis; D014511:Uremia / Q000503:physiopathology