Effect of captopril on the development of left ventricular hypertrophy in rabbits with aortic insufficiency.
We investigated the effect of captopril on the growth of the left ventricle in an experimental model of aortic insufficiency. Four groups of rabbits were studied 28 days after experimental intervention: 1. control, 2. control with captopril (10 mg/kg/day), 3. aortic insufficiency, 4. aortic insufficiency with captopril (10 mg/kg/day). Aortic insufficiency induced hypertrophic growth of the left ventricle demonstrated by increased weight and ribonucleic acid (RNA) concentration. Administration of captopril only slightly attenuated the weight increase of the left ventricle and the increase in concentration of left ventricular RNA. However, captopril reduced the concentration of left ventricular deoxyribonucleic acid (DNA) both in the control and even more in the group with aortic insufficiency. The chronic haemodynamic overload enhanced mitochondrial respiration in the left ventricle which was not influenced by captopril. We conclude that captopril in the dose 10 mg/kg/day did not prevent hypertrophy of the left ventricle but reduced left ventricular DNA concentration.
Simko
F
F
Institute of Pathophysiology, Faculty of Medicine, Comenius University, Bratislava, Slovak Republic.
Pechánová
O
O
Bernátová
I
I
Gvozdjáková
A
A
Kucharská
J
J
Hulín
I
I
Bada
V
V
Turcáni
M
M
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D001022:Aortic Valve Insufficiency / Q000150:complications*; D001835:Body Weight / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology*; D004734:Energy Metabolism / Q000187:drug effects; D017379:Hypertrophy, Left Ventricular / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D008297:Male; D009206:Myocardium / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D010766:Phosphorylation; D012313:RNA / Q000378:metabolism; D011817:Rabbits
D000806:Angiotensin-Converting Enzyme Inhibitors; D012313:RNA; D002216:Captopril