title: Superoxide radical scavenging by phenolic bronchodilators under aprotic and aqueous conditions.
abstract: Asthmatic airway disease is accompanied by the appearance of inflammatory cells which produce reactive oxygen species (ROS). Therefore, the radical scavenging properties of the bronchodilators reproterol, fenoterol, salbutamol and terbutaline toward superoxide anion radicals and hydroperoxyl radicals were investigated in a model system by electron paramagnetic resonance spectroscopy (EPR) and photometric approaches. The substances under study showed activity in superoxide radical scavenging under aprotic and protic conditions as well. The efficiency of the reaction decreased in the order: fenoterol > salbutamol > reproterol > terbutaline > oxyfedrine when DMSO was used as an aprotic solvent. In an aqueous system, the rate constants decreased in the order: fenoterol > reproterol > salbutamol. It is suggested that the antioxidant effect of these beta2-agonists is an additional advantage in treatment of asthmatic lung disease, reducing the negative consequences of airway inflammation.
authors.affiliation: Universitätsklinikum, Zentrum der Biologischen Chemie, Frankfurt am Main, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Zwicker
authors.forename: W
authors.initials: W
authors.lastname: Damerau
authors.forename: S
authors.initials: S
authors.lastname: Dikalov
authors.forename: H
authors.initials: H
authors.lastname: Scholtyssek
authors.forename: I
authors.initials: I
authors.lastname: Schimke
authors.forename: G
authors.initials: G
authors.lastname: Zimmer
mesh_terms: D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000420:Albuterol / Q000494:pharmacology; D001993:Bronchodilator Agents / Q000494:pharmacology*; D004338:Drug Combinations; D004578:Electron Spin Resonance Spectroscopy; D005280:Fenoterol / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000494:pharmacology*; D009921:Metaproterenol / Q000031:analogs & derivatives / Q000494:pharmacology; D013481:Superoxides / Q000378:metabolism*; D013806:Theophylline / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D000318:Adrenergic beta-Agonists; D001993:Bronchodilator Agents; D004338:Drug Combinations; D016166:Free Radical Scavengers; D013481:Superoxides; C014792:reproterol; D005280:Fenoterol; D009921:Metaproterenol; D013806:Theophylline; D000420:Albuterol