Ethanol stimulates the formation of free oxygen radicals in the brain of newborn rats.
The possibility of free radicals effects in ethanol-induced teratogenesis was investigated by determining the production of reactive oxygen species (ROS) in the neonatal rat brain. Ethanol 33% was administered daily, by i.p. injection from day 8 of pregnancy to day 6-8 p.n. The presence of the lipid peroxidation process (indicating ROS formation) was determined by using a qualitative and quantitative analysis of malondialdehyde (MDA). An important increase of MDA was found suggesting the involvement of ROS in the pathogenetic mechanism of alcohol embryo- and fetopathy.
Mureşan
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Laboratory of Embryology and Teratology, Center of Medicine and for Sanitary Services and Management, Timişoara, Romania.
Eremia
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I
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D008315:Malondialdehyde / Q000032:analysis; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013723:Teratogens / Q000633:toxicity*
D005609:Free Radicals; D017382:Reactive Oxygen Species; D013723:Teratogens; D000431:Ethanol; D008315:Malondialdehyde