[The good use of antibiotics in intensive care: results of a program for rationalization of prescriptions].
OBJECTIVE
To assess the impact of an antibiotic prescribing programme in a intensive therapy unit.


METHODS
Prospective comparative study.


METHODS
We compared antibiotic prescriptions and bacterial susceptibility to antimicrobial agents before and after introduction of a programme focusing on injection control and therapeutic indications.


RESULTS
The introduction of the programme resulted in a major decrease in antibiotic administration. Moreover, the susceptibility of Pseudomonas aeruginosa to ticarcillin increased from 40 to 68%, and susceptibility of Staphylococcus aureus to methicillin increased from 55 to 73%.


CONCLUSIONS
Antibiotic control policies must be considered integral to any effort to decrease resistance and cost of therapy with antibiotics.
Mohammedi
I
I
Service de réanimation, hôpital Edouard-Herriot, Lyon, France.
Duperret
S
S
Védrinne
J M
JM
Allaouchiche
B
B
Bui-Xuan
B
B
Boulétreau
P
P
D000900:Anti-Bacterial Agents / Q000191:economics / Q000627:therapeutic use*; D003422:Critical Care / Q000191:economics / Q000592:standards*; D011307:Drug Prescriptions / Q000191:economics / Q000592:standards*; D004363:Drug Utilization; D005260:Female; D005602:France; D006801:Humans; D008297:Male; D008712:Methicillin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010406:Penicillins / Q000494:pharmacology; D011446:Prospective Studies; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012151:Resuscitation; D013211:Staphylococcus aureus / Q000187:drug effects; D013982:Ticarcillin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D010406:Penicillins; D013982:Ticarcillin; D008712:Methicillin