Cytogenetic localization of cancer-related genes in the rat and comparative mapping studies in human and mouse.
The rat is an important model organism in biomedical research, and several well-characterized rat cancer model systems exist. To facilitate detailed analysis of these models, it is useful to know the regional location of known cancer-related genes. In this report, 14 cancer-related genes have been sublocalized by fluorescence in situ hybridization. The mapped genes include three oncogenes (Fyn, Mas1, and Vav1), a tyrosine kinase gene (Syk), a tumor-associated antigen gene (Cd24), a growth factor receptor gene (Igf2r), the gene for an activator of c-fos/c-jun transcription factors (Apex), a transcription factor gene (Egr3), and several genes involved in steroid hormone metabolism and signaling (Esr2, Pgr, Cbg, Cyp17, and Cyp19). The remaining gene (Map1a) is involved in microtubule assembly.
Johansson
A
A
Department of Cell and Molecular Biology-Genetics, Gothenburg University, Gothenburg, Sweden. Asa.Johansson@gen.gu.se
Helou
K
K
Levan
G
G
D000818:Animals; D015703:Antigens, CD / Q000235:genetics; D051927:CD24 Antigen; D019757:Carbon-Oxygen Lyases; D002874:Chromosome Mapping; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase; D004268:DNA-Binding Proteins / Q000235:genetics; D051776:Early Growth Response Protein 3; D004792:Enzyme Precursors / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D047908:Intracellular Signaling Peptides and Proteins; D008562:Membrane Glycoproteins; D051379:Mice / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D009374:Neoplasms, Experimental / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics; D009857:Oncogenes; D011505:Protein-Tyrosine Kinases / Q000235:genetics; D000090063:Proto-Oncogene Mas; D051381:Rats / Q000235:genetics*; D013045:Species Specificity; D000072377:Syk Kinase; D014157:Transcription Factors / Q000235:genetics
D015703:Antigens, CD; D051927:CD24 Antigen; C497889:CD24 protein, human; C497890:Cd24a protein, mouse; D004268:DNA-Binding Proteins; C497369:Egr3 protein, mouse; C497370:Egr3 protein, rat; D004792:Enzyme Precursors; D047908:Intracellular Signaling Peptides and Proteins; C000715470:MAS1 protein, human; C000715471:Mas1 protein, mouse; C000715472:Mas1 protein, rat; D008562:Membrane Glycoproteins; D009687:Nuclear Proteins; D000090063:Proto-Oncogene Mas; D014157:Transcription Factors; D051776:Early Growth Response Protein 3; D003577:Cytochrome P-450 Enzyme System; D011505:Protein-Tyrosine Kinases; C000606896:SYK protein, human; D000072377:Syk Kinase; C000606897:Syk protein, mouse; C000606898:Syk protein, rat; D019757:Carbon-Oxygen Lyases; C085108:APEX1 protein, human; C486216:Apex1 protein, mouse; C470319:Apex1 protein, rat; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase