[Apoptotic cell death in response to dengue virus infection: what are the consequences of viral pathogenesis?].
Dengue is a human disease of viral etiology which may be fatal in its hemorragic form. It is widely spread in the tropical areas of the different continents and has been dramatically expanding over the past 30 years. Although an immunological disorder is thought to be involved in dengue physiological symptoms, the pathogenesis of dengue hemorragic fever has not yet been elucidated. Whether the immune response is deleterious or beneficial to the host remains a matter of debate. Other factors, related to virus replication in specific host cells, could also contribute to the severity of the disease. Apoptotic cell death is one of the important consequences of dengue virus infection both in vitro and in vivo. Dengue replication triggers apoptotic signals in neurons and hepatocytes although the original effectors and kinetics differ. Implications of the ongoing apoptotic processes in viral pathogenesis will be further discussed.
Marianneau
P
P
Unité des arbovirus et virus des fièvres hémorragiques, Institut Pasteur, Paris.
Flamand
M
M
Courageot
M P
MP
Deubel
V
V
Desprès
P
P
D000818:Animals; D017209:Apoptosis; D003588:Cytopathogenic Effect, Viral; D003715:Dengue / Q000209:etiology / Q000473:pathology*; D003716:Dengue Virus / Q000472:pathogenicity* / Q000502:physiology; D006801:Humans; D008099:Liver / Q000821:virology; D009474:Neurons / Q000821:virology; D014779:Virus Replication