[QT interval and drugs. Recommendation for drug prescription for patients with long QT syndrome. Clinical Research Group of INSERM 4940 12: Diagnostic Clinic of Congenital Long QT Syndrome].
The genetics of the long QT syndrome are now better understood. However, there is much heterogeneity as three different genes have already been identified affecting the function of sodium and potassium channels. The aim of these recommendations is to draw up a list of drugs which are contraindicated or not recommended in patients with congenital long QT syndromes. The conraindicated drugs are those with which torsades de pointe have already been described. Drugs not recommended are substances which are not electrohysiologically neutral and for which, in view of their modes of action, their metabolism or belonging to a particular therapeutic class, make them very difficult to use in those patients. It is therefore better not to prescribe them whenever possible in this condition. These substances belong mainly to cardiovascular (especially antiarrhythmic), psychotropic, anti-infectious and antiallergic groups of drugs.
Le Heuzey
J Y
JY
Service de cardiologie A, hôpital Broussais, Paris.
Davy
J M
JM
Weissenburger
J
J
Guicheney
P
P
Le Marec
H
H
Chevalier
P
P
Denjoy
I
I
Leenhardt
A
A
Charpentier
F
F
Coumel
P
P
D018926:Anti-Allergic Agents; D000889:Anti-Arrhythmia Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents / Q000009:adverse effects; D000075202:Contraindications; D011307:Drug Prescriptions; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008133:Long QT Syndrome / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D011619:Psychotropic Drugs; D013575:Syncope / Q000139:chemically induced / Q000517:prevention & control
D018926:Anti-Allergic Agents; D000889:Anti-Arrhythmia Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D011619:Psychotropic Drugs