title: Cytokine production by CD4 and CD8 T cells during the growth of Mycobacterium tuberculosis in mice.
abstract: Changes in the pattern of cytokines found in CD4 and CD8 T cells during the growth of Mycobacterium tuberculosis that resulted in the establishment of a latent infection were monitored. Subsets of T cells were identified based on their differential expression of CD45 and CD44 which allowed them to be classified as naive, activated or memory. We found that the T cells in the lung produced a predominantly type 1 cytokine response. The appearance of large numbers of Th1 cells coincided with the establishment of latency. In contrast, the predominant response in the mediastinal lymph node and spleen was a Th2-type response.
authors.affiliation: Department of Microbiology, The Ohio State University, Columbus 43210, USA.
authors.forename: A D
authors.initials: AD
authors.lastname: Howard
authors.forename: B S
authors.initials: BS
authors.lastname: Zwilling
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D016207:Cytokines / Q000096:biosynthesis*; D007156:Immunologic Memory; D008168:Lung / Q000276:immunology; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009169:Mycobacterium tuberculosis / Q000254:growth & development*
chemical_list: D016207:Cytokines