title: Lewy body in neurodegeneration with brain iron accumulation type 1 is immunoreactive for alpha-synuclein.
abstract: In familial PD, a mutation of the alpha-synuclein gene has been identified. Alpha-synuclein also was revealed in Lewy bodies in idiopathic PD. Lewy bodies in neurodegeneration with brain iron accumulation type 1 (NBIA 1; Hallervorden-Spatz syndrome) were found to show immunostaining for alpha-synuclein/precursor of non-A beta component of Alzheimer's disease amyloid, indicating that alpha-synuclein is commonly associated with the formation of Lewy bodies in other sporadic and familial neurodegenerative diseases apart from PD.
authors.affiliation: Department of Molecular Biology, Tokyo Institute of Psychiatry, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Arawaka
authors.forename: Y
authors.initials: Y
authors.lastname: Saito
authors.forename: S
authors.initials: S
authors.lastname: Murayama
authors.forename: H
authors.initials: H
authors.lastname: Mori
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007501:Iron / Q000378:metabolism*; D016631:Lewy Bodies / Q000378:metabolism / Q000473:pathology*; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000473:pathology*; D006211:Pantothenate Kinase-Associated Neurodegeneration / Q000378:metabolism / Q000473:pathology*; D010300:Parkinson Disease / Q000378:metabolism; D051843:Synucleins; D014452:Ubiquitins / Q000378:metabolism; D051844:alpha-Synuclein
chemical_list: D009419:Nerve Tissue Proteins; C497604:SNCA protein, human; D051843:Synucleins; D014452:Ubiquitins; D051844:alpha-Synuclein; D007501:Iron