Augmented intrathecal secretion of interferon-gamma in response to Borrelia garinii in neuroborreliosis.
The Lyme disease agent Borrelia garinii has been suggested to be neurotrop, preferentially affecting the nervous system. We compared the secretion of interferon-gamma in response to outer surface proteins from Borrelia garinii and Borrelia afzelii in 10 patients with neuroborreliosis. In cerebrospinal fluid, stimulation with Borrelia garinii revealed higher numbers of interferon-gamma-secreting cells in all patients, whereas in blood, only five displayed higher numbers. This further strengthens the hypothesis of Borrelia garinii being associated with the development of neuroborreliosis.
Ekerfelt
C
C
Department of Neuroscience and Locomotion, Faculty of Health Sciences, University Hospital, Linköping, Sweden. christina.ekerfelt@kfc.liu.se
Ernerudh
J
J
Forsberg
P
P
Bergström
S
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000942:Antigens, Bacterial / Q000134:cerebrospinal fluid; D001898:Borrelia / Q000276:immunology*; D001899:Borrelia Infections / Q000276:immunology*; D002555:Cerebrospinal Fluid / Q000166:cytology / Q000276:immunology / Q000382:microbiology; D002648:Child; D005260:Female; D006801:Humans; D007118:Immunoassay; D007371:Interferon-gamma / Q000134:cerebrospinal fluid* / Q000276:immunology / Q000378:metabolism*; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000276:immunology* / Q000382:microbiology
D000942:Antigens, Bacterial; D007371:Interferon-gamma