Adult-onset Still's disease associated with G6PD deficiency: a case report and literature review.
A 37-year-old man presented with symptoms consistent with adult-onset Still's disease. Fever and leukocytosis were prominent, and the patient was started on high-dose aspirin for possible acute rheumatic fever. He developed severe anemia as a result of glucose-6-phosphate dehydrogenase deficiency. His treatment was changed to naproxen, and he recovered with restoration of his hematologic parameters. Although Still's disease is frequently accompanied by mild-to-moderate anemia, the development of severe anemia should raise the possibilities of hemolysis secondary to glucose-6-phosphate dehydrogenase deficiency.
Khurana
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Department of Medicine, State University of New York Health Sciences Center at Brooklyn 11203, USA.
Bradley
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TP
D000328:Adult; D000740:Anemia / Q000209:etiology; D044383:Black People; D005334:Fever / Q000209:etiology; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications*; D006801:Humans; D007964:Leukocytosis / Q000209:etiology; D008297:Male; D016706:Still's Disease, Adult-Onset / Q000097:blood / Q000209:etiology*