Pre-eclampsia: a disorder of placental mitochondria?
Pre-eclampsia is a common, pregnancy-induced, multisystem disease leading to severe complications in the mother and foetus. The aetiology of pre-eclampsia remains a mystery, but a growing body of evidence suggests that a mitochondrial defect might cause the impairement of differentiation and invasion of the trophoblast that leads to this disorder. This hypothesis is the topic of ongoing studies that, if confirmed, would be highly relevant to preventative strategies for this disease.
Widschwendter
M
M
Dept of Gynecology and Obstetrics, Innsbruck University, Austria. Martin.Widschwendter@uibk.ac.at
Schröcksnadel
H
H
Mörtl
M G
MG
D004272:DNA, Mitochondrial / Q000235:genetics; D005260:Female; D006801:Humans; D008928:Mitochondria / Q000235:genetics*; D010920:Placenta / Q000503:physiopathology*; D011225:Pre-Eclampsia / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology*; D011247:Pregnancy
D004272:DNA, Mitochondrial