title: Synthesis, structure, and biological activities of some N-(4,5-dihydro-1H-imidazol-2-yl)-1,3-dihydrobenzimidazole derivatives.
abstract: A series of novel N-(4,5-dihydroimidazol-2-yl)-1,3-dihydrobenzimidazole derivatives 2a-d, 3a-d and 4a-p were prepared and their structure was determined by IR and NMR spectroscopic data as well as X-ray analysis of carbonitrile 2a. The compounds were studied as potential inhibitors of the human blood platelet aggregation induced by adrenaline or ADP. Compounds of type 3 proved efficacious for the reduction of arterial blood pressure upon intravenous administration to normotensive rats.
authors.affiliation: Department of Organic Chemistry, Medical University of Gdańsk, Poland.
authors.forename: F
authors.initials: F
authors.lastname: Saczewski
authors.forename: T
authors.initials: T
authors.lastname: Debowski
authors.forename: J
authors.initials: J
authors.lastname: Petrusewicz
authors.forename: H
authors.initials: H
authors.lastname: Trzeciak
authors.forename: E
authors.initials: E
authors.lastname: Krzystanek
authors.forename: M
authors.initials: M
authors.lastname: Krzystanek
authors.forename: M
authors.initials: M
authors.lastname: Gdaniec
authors.forename: E
authors.initials: E
authors.lastname: Nowakowska
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats
chemical_list: D001562:Benzimidazoles; D010975:Platelet Aggregation Inhibitors