title: A comparative study of osseointegration of titanium implants in autogenous and freeze-dried bone grafts.
abstract: OBJECTIVE
  This study was undertaken to compare the rate and degree of osseointegration of dental implants when placed into either autogenous corticocancellous chip or freeze-dried corticocancellous chip bone grafts.
  
  
  METHODS
  The canine ilium was used as the model site. Thirty experimental and 15 control implants were placed in 15 dogs: autogenous versus freeze-dried corticocancellous chip bone grafts around the exposed implant surfaces. In addition to the placement of control implants, the apical portion of the grafted implants acted as their own control. The implants were harvested at 1, 2, and 3 months. The evaluation of the integration process was performed by means of light microscopy, microradiography, and histomorphometry.
  
  
  RESULTS
  Using this model, the results indicate that at 1 month there was no statistical difference in the degree of osseointegration in the two bone grafts. At 2 months, there was a statistically greater degree of osseointegration noted in the autogenous corticocancellous chip sites than in the freeze-dried bone grafts. At 3 months, the degree of osseointegration in the two groups was 70% and 33%, respectively. At 3 months, there was virtually 100% integration with trabecular bone at the control implant sites.
  
  
  CONCLUSIONS
  The results indicate that at 2 months postoperatively implants placed in an autogenous bone chip graft osseointegrate to a significantly greater degree than implants placed in a freeze-dried bone chip graft, and this difference remains at 3 months.
authors.affiliation: University of Iowa, Iowa City, USA.
authors.forename: K J
authors.initials: KJ
authors.lastname: Pansegrau
authors.forename: K L
authors.initials: KL
authors.lastname: Fridrich
authors.forename: D
authors.initials: D
authors.lastname: Lew
authors.forename: J C
authors.initials: JC
authors.lastname: Keller
mesh_terms: D000818:Animals; D016025:Bone Transplantation; D004285:Dogs; D005612:Freeze Drying; D007085:Ilium / Q000601:surgery; D016348:Osseointegration; D014025:Titanium; D014182:Transplantation, Autologous
chemical_list: D014025:Titanium