title: Protein-mediated base flipping.
abstract: Since the discovery that the DNA methyltransferase M.HhaI utilises a base flipping mechanism to expose its target cytosine during catalysis, this phenomenon has been observed in other nucleic acid modifying enzymes. The crystallographic analyses of such enzyme-DNA complexes have revealed the molecular features of extrahelical base stabilisation, but have been less informative about the flipping process itself.
authors.affiliation: Krebs Institute for Biomolecular Research Department of Molecular Biology University of Sheffield Western Bank Sheffield, S10 2TN, UK d.hornby@sheffield.ac.uk
authors.initials: DP
authors.lastname: Hornby
authors.initials: GC
authors.lastname: Ford