title: Resistance of Fc receptor- deficient mice to fatal glomerulonephritis.
abstract: Immune complex-mediated inflammation is a common mechanism of various autoimmune diseases. Glomerulonephritis (GN) is one of these diseases, and the main mechanism of the induction of GN has been unclear. We examined the contribution of Fc receptors in the induction of nephrotoxic GN by establishing and analyzing mice deficient in the Fc receptor gamma chain (FcRgamma). Whereas all wild-type mice died from severe glomerulonephritis with hypernitremia by administration of anti-glomerular basement membrane (GBM) antibodies, all FcRgamma-deficient mice survived. Histologically, wild-type mice showed glomerular hypercellularity and thrombotic changes, whereas the renal tissue in FcRgamma-deficient mice was almost intact. Deposition of anti-GBM antibody as well as complement components in the GBM were equally observed in both wild-type and knockout mice. These results demonstrate that the triggering of this type of glomerulonephritis is completely dependent on FcR+ cells.
authors.affiliation: Department of Molecular Genetics, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.
authors.forename: S Y
authors.initials: SY
authors.lastname: Park
authors.forename: S
authors.initials: S
authors.lastname: Ueda
authors.forename: H
authors.initials: H
authors.lastname: Ohno
authors.forename: Y
authors.initials: Y
authors.lastname: Hamano
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: T
authors.initials: T
authors.lastname: Shiratori
authors.forename: T
authors.initials: T
authors.lastname: Yamazaki
authors.forename: H
authors.initials: H
authors.lastname: Arase
authors.forename: N
authors.initials: N
authors.lastname: Arase
authors.forename: A
authors.initials: A
authors.lastname: Karasawa
authors.forename: S
authors.initials: S
authors.lastname: Sato
authors.forename: B
authors.initials: B
authors.lastname: Ledermann
authors.forename: Y
authors.initials: Y
authors.lastname: Kondo
authors.forename: K
authors.initials: K
authors.lastname: Okumura
authors.forename: C
authors.initials: C
authors.lastname: Ra
authors.forename: T
authors.initials: T
authors.lastname: Saito
mesh_terms: D000818:Animals; D019867:Anti-Glomerular Basement Membrane Disease / Q000209:etiology* / Q000401:mortality; D000936:Antigen-Antibody Complex / Q000378:metabolism; D003404:Creatinine / Q000097:blood; D004195:Disease Models, Animal; D005260:Female; D007678:Kidney Glomerulus / Q000473:pathology; D008264:Macrophages / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D010587:Phagocytosis; D017452:Receptors, IgG / Q000172:deficiency* / Q000235:genetics; D012737:Sex Factors; D014508:Urea / Q000097:blood
chemical_list: D000936:Antigen-Antibody Complex; D017452:Receptors, IgG; D014508:Urea; D003404:Creatinine