[Orbital edema induced by psychotropic drugs?].
BACKGROUND
Drugs known to be responsible for orbital edema are calcium channel blockers, rifampicin, atracurarium, methylprednisolone and mannitol. We describe three patients with orbital edema induced by psychotropic drugs administrated for a long period of time.


METHODS
These patients were aged 51 to 73 years, and had orbital edema predominant in the morning, but persisting during the day. All the other causes of orbital edema--including steatoblepharon--were ruled out by medical history and investigations. In one case the edema decreased after the interruption of nearly all psychotropic drugs.


CONCLUSIONS
The exclusive orbital localization of the edema suggests a local or regional mechanism that could be an exacerbation of the physiological morning orbital edema induced by decreased lymphatic flow. This flow is usually enhanced by gravity and automatic palpebral blinking.
Scrivener
Y
Y
Clinique Dermatologique, Hôpitaux Universitaires de Strasbourg.
Cribier
B
B
Le Coz
C
C
Grosshans
E
E
D000368:Aged; D004487:Edema / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009915:Orbit / Q000473:pathology*; D011619:Psychotropic Drugs / Q000009:adverse effects*; D014149:Tranquilizing Agents / Q000009:adverse effects
D011619:Psychotropic Drugs; D014149:Tranquilizing Agents