title: A study of dipole localization accuracy for MEG and EEG using a human skull phantom.
abstract: OBJECTIVE
  To investigate the accuracy of forward and inverse techniques for EEG and MEG dipole localization.
  
  
  METHODS
  A human skull phantom was constructed with brain, skull and scalp layers and realistic relative conductivities. Thirty two independent current dipoles were distributed within the 'brain' region and EEG and MEG data collected separately for each dipole. The true dipole locations and orientations and the morphology of the brain, skull and scalp layers were extracted from X-ray CT data. The location of each dipole was estimated from the EEG and MEG data using the R-MUSIC inverse method and forward models based on spherical and realistic head geometries. Additional computer simulations were performed to investigate the factors affecting localization accuracy.
  
  
  RESULTS
  Localization errors using the relatively simpler locally fitted sphere approach are only slightly greater than those using a BEM approach. The average localization error over the 32 dipoles was 7-8 mm for EEG and 3 mm for MEG.
  
  
  CONCLUSIONS
  The superior performance of MEG over EEG appears to be because the latter is more sensitive to errors in the forward model arising from simplifying assumptions concerning the conductivity of the skull, scalp and brain.
authors.affiliation: Signal & Image Processing Institute, University of Southern California, Los Angeles 90089, USA. leahy@sipi.usc.edu
authors.forename: R M
authors.initials: RM
authors.lastname: Leahy
authors.forename: J C
authors.initials: JC
authors.lastname: Mosher
authors.forename: M E
authors.initials: ME
authors.lastname: Spencer
authors.forename: M X
authors.initials: MX
authors.lastname: Huang
authors.forename: J D
authors.initials: JD
authors.lastname: Lewine
mesh_terms: D003198:Computer Simulation; D004569:Electroencephalography / Q000592:standards*; D006801:Humans; D015225:Magnetoencephalography / Q000592:standards*; D008954:Models, Biological; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012886:Skull / Q000033:anatomy & histology / Q000000981:diagnostic imaging*; D012984:Software; D014057:Tomography, X-Ray Computed