title: [Magnetization transfer contrast (MTC)--which is the most MTC-sensitive MRI sequence?].
abstract: OBJECTIVE
  This study aimed at evaluating MTC-sensitivity of frequently used MR-sequences.
  
  
  METHODS
  7 sequences (T1-, T2-, PD-weighted SE, four gradient-echo sequences) were combined with a 4 element on-resonance MT-Pulse at 0.5 Tesla (T5, Philips medical systems). The measurements were performed at a knee joint and MT-ratios of cartilage, muscle, fat and a copper sulfate phantom were calculated.
  
  
  RESULTS
  Proton density weighted gradient and to a lesser degree spin-echo sequences were superior to T1- and T2-weighted sequences in visualising the MT effects.
  
  
  CONCLUSIONS
  It is important to choose an appropriate MR-sequence for MTC experiments. Proton-density gradient echo sequences are recommended for that purpose. T1- and T2-weighted SE sequences should be avoided.
authors.affiliation: Radiologische Universitätsklinik Bonn.
authors.forename: M
authors.initials: M
authors.lastname: Vahlensieck
authors.forename: J
authors.initials: J
authors.lastname: Gieseke
authors.forename: F
authors.initials: F
authors.lastname: Träber
authors.forename: H
authors.initials: H
authors.lastname: Schild
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology; D002358:Cartilage, Articular / Q000033:anatomy & histology; D019327:Copper Sulfate; D006801:Humans; D007719:Knee Joint / Q000033:anatomy & histology* / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D018482:Muscle, Skeletal / Q000033:anatomy & histology; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D019327:Copper Sulfate