title: [Fatal hepatitis in a young child: probable role of halothane].
abstract: A 3-year-old boy, who underwent multiple anaesthetics including halothane in a short period of time, developed 3 days after the last operation abdominal pain, jaundice and fever. Laboratory tests showed hepatic failure, with cytolysis, cholestasis and eosinophilia. Tests for hepatitis A, B, C, CMV and EBV were negative. No other causes of postoperative jaundice were identified. Despite symptomatic treatment, the child died 5 days after the last anaesthetic. Post mortem liver biopsy showed massive hepatic necrosis. The authors discuss factors increasing the risk for halothane-hepatitis, especially multiple exposures.
authors.affiliation: Département d'anesthésie-réanimation, CHU Ibn Rochd Casablanca, Maroc.
authors.forename: K
authors.initials: K
authors.lastname: Mjahed
authors.forename: A
authors.initials: A
authors.lastname: Sadraoui
authors.forename: S
authors.initials: S
authors.lastname: Salmi
authors.forename: M
authors.initials: M
authors.lastname: Laraki
authors.forename: M
authors.initials: M
authors.lastname: Benaguida
mesh_terms: D000063:Accidents, Traffic; D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D002675:Child, Preschool; D017809:Fatal Outcome; D006221:Halothane / Q000009:adverse effects*; D006801:Humans; D008297:Male; D010388:Pelvis / Q000293:injuries; D011183:Postoperative Complications / Q000139:chemically induced*; D014513:Ureter / Q000293:injuries
chemical_list: D018685:Anesthetics, Inhalation; D006221:Halothane