Two new steroidal alkaloids, 20-isoveratramine and verapatuline, from the roots and rhizomes of veratrum patulum
Roots and rhizomes of Veratrum patulum L. (Liliaceae), used as a source of the Chinese crude drug "Li-lu", have yielded two new steroidal alkaloids, 20-isoveratramine (1) and verapatuline (2), along with three known alkaloids, veratramine (3), veratrosine (4), and jervine (5). Structures of new alkaloids 1 and 2 were determined to be a C-20 epimer of 3 and N-(methoxycarbonyl)jervine, respectively, by the use of spectral data including 2D NMR.
Tezuka
Y
Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan, and Research Institute for Medical and Pharmaceutical Science, Dalian, Chunyangji.
Kikuchi
T
Zhao
W
Chen
J
Guo
Y