title: Relationship between changes in dietary sucrose and high density lipoprotein cholesterol: the CARDIA study. Coronary Artery Risk Development in Young Adults.
abstract: OBJECTIVE
  Cross-sectional data from several observational studies have suggested that dietary sucrose may be inversely associated with high density lipoprotein cholesterol (HDL-C). This study examined associations between energy from dietary sucrose and HDL-C at baseline, year 7 and longitudinally (year 7 minus baseline) in a cohort of young black and white men and women from the Coronary Artery Risk Development in Young Adults (CARDIA) study.
  
  
  METHODS
  The sample included 4734 black men, black women, white men and white women, ages 18-30 years, in 1985-86 (baseline); 3513 at year 7; and 3335 for longitudinal analyses. Multivariate analyses was used with adjustment for age, BMI, cigarettes smoked per day, physical activity score, and alcohol intake.
  
  
  RESULTS
  Multivariate analyses indicated that energy intake from sucrose was inversely associated with HDL-C for each race-gender group at baseline, year 7, and longitudinally from baseline to year 7. This association was significant at baseline for black men, and white men and women (p < 0.01); at year 7 for white men and black women (p < 0.01), and longitudinally for white men, white women, and black women (p < 0.05).
  
  
  CONCLUSIONS
  The consistent inverse associations between energy from dietary sucrose and HDL-C observed in both cross-sectional and longitudinal analyses, and in different race and gender groups in CARDIA suggest that lowering dietary sucrose intake may be beneficial for those who may have low HDL-C.
authors.affiliation: Northwestern University Medical School, Department of Preventive Medicine, Chicago, IL 60611, USA.
authors.forename: S L
authors.initials: SL
authors.lastname: Archer
authors.forename: K
authors.initials: K
authors.lastname: Liu
authors.forename: A R
authors.initials: AR
authors.lastname: Dyer
authors.forename: K J
authors.initials: KJ
authors.lastname: Ruth
authors.forename: D R
authors.initials: DR
authors.lastname: Jacobs
authors.forename: L
authors.initials: L
authors.lastname: Van Horn
authors.forename: J E
authors.initials: JE
authors.lastname: Hilner
authors.forename: P J
authors.initials: PJ
authors.lastname: Savage
mesh_terms: D000293:Adolescent; D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data; D008076:Cholesterol, HDL / Q000097:blood*; D003327:Coronary Disease / Q000209:etiology*; D003430:Cross-Sectional Studies; D004034:Diet Surveys; D019422:Dietary Sucrose / Q000009:adverse effects*; D002149:Energy Intake; D005260:Female; D006801:Humans; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D015999:Multivariate Analysis; D012307:Risk Factors; D011795:Surveys and Questionnaires; D044465:White People / Q000706:statistics & numerical data
chemical_list: D008076:Cholesterol, HDL; D019422:Dietary Sucrose