title: Superior efficacy of liposomal amphotericin B with prolonged circulation in blood in the treatment of severe candidiasis in leukopenic mice.
abstract: In leukopenic mice with severe systemic candidiasis, single-dose treatment (5 mg of amphotericin B [AMB]/kg of body weight) with long-circulating polyethylene glycol-coated AMB liposomes (PEG-AMB-LIP) resulted in zero mortality and a significant reduction in the number of viable Candida albicans in the kidney, whereas 70% mortality was seen in mice treated with five daily doses of AmBisome (5 mg of AMB/kg . day). When the first of five daily doses of AmBisome was combined with a single low dose of Fungizone (0.1 mg of AMB/kg), the efficacy was equal to that of PEG-AMB-LIP.
authors.affiliation: Department of Medical Microbiology and Infectious Diseases, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands. vanetten@kmic.fgg.eur.nl
authors.forename: E W
authors.initials: EW
authors.lastname: van Etten
authors.forename: S V
authors.initials: SV
authors.lastname: Snijders
authors.forename: W
authors.initials: W
authors.lastname: van Vianen
authors.forename: I A
authors.initials: IA
authors.lastname: Bakker-Woudenberg
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage* / Q000097:blood; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage*; D002177:Candidiasis / Q000188:drug therapy*; D004337:Drug Carriers; D007970:Leukopenia / Q000150:complications*; D008081:Liposomes; D051379:Mice
chemical_list: D000935:Antifungal Agents; D004337:Drug Carriers; D008081:Liposomes; D000666:Amphotericin B