title: DNA double-strand breaks, chromosomal rearrangements, and genomic instability.
abstract: DNA double-strand breaks can lead to chromosomal rearrangements at the first mitosis after exposure to the DNA strand-breaking agent. The evidence suggests a number of different pathways for DNA double-strand break rejoining in mammalian cells, but it is unclear what factors determine the fate of the induced break and whether or not it will lead to chromosomal rearrangement. If a cell does survive and proliferate after DNA cleavage, delayed chromosomal instability can be observed in the clonal descendants of the exposed cell. Most, but not all DNA double-strand breaking agents are effective at inducing this delayed chromosomal instability. In this paper, we review the evidence for the role of the DNA double-strand break in directly induced and delayed chromosomal rearrangements.
authors.affiliation: Departments of Radiation Oncology and Radiology, Box 0750, University of California, San Francisco, CA 94143-0750, USA. morgan@itsa.ucsf.edu
authors.forename: W F
authors.initials: WF
authors.lastname: Morgan
authors.forename: J
authors.initials: J
authors.lastname: Corcoran
authors.forename: A
authors.initials: A
authors.lastname: Hartmann
authors.forename: M I
authors.initials: MI
authors.lastname: Kaplan
authors.forename: C L
authors.initials: CL
authors.lastname: Limoli
authors.forename: B
authors.initials: B
authors.lastname: Ponnaiya
mesh_terms: D000818:Animals; D016466:CHO Cells; D002869:Chromosome Aberrations; D019457:Chromosome Breakage / Q000235:genetics*; D006224:Cricetinae; D004247:DNA / Q000737:chemistry*; D004249:DNA Damage / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics; D004262:DNA Restriction Enzymes / Q000378:metabolism; D008322:Mammals
chemical_list: D004247:DNA; D004262:DNA Restriction Enzymes