Three dolabellanes and a macrolide from the sponge Dysidea sp. from Palau.
A specimen of Dysidea sp. from Palau contained three new dolabellane diterpenes 1-3 and an unstable 14-membered macrolide, arenolide (4), which showed modest cytotoxicity. From a chemotaxonomic viewpoint, these metabolites are so unusual that we discuss their possible origin.
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Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093-0212, USA.
Faulkner
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DJ
D000818:Animals; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D018942:Macrolides / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D019029:Palau; D011161:Porifera / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D004224:Diterpenes; D018942:Macrolides; C115566:dolabellane