Antiallergic activities of rabdosiin and its related compounds: chemical and biochemical evaluations.
We examined the effects of caffeic acid-containing compounds such as chlorogenic acid, rosmarinic acid and rabdosiin on anti-allergic activities involving active oxygens scavenging activity as well as inhibitory activities of hyaluronidase and beta-hexosaminidase release. Rabdosiin exhibited the highest hyaluronidase-inhibitory activity and scavenging activities against active oxygens species such as superoxide anion radicals and hydroxyl radicals among the tested compounds. Both rabdosiin and caffeic acid inhibited beta-hexosaminidase release from cultured cells more than 90% at 2 mM. The inhibition by rosmarinic acid and chlorogenic acid were weaker than that of rabdosiin. From these results, rabdosiin has been proposed to possess anti-allergic activity.
Ito
H
H
Research & Development Center, Nagase & Co., Ltd., Kobe, Japan. hisatomi.ito@nagase.co.jp
Miyazaki
T
T
Ono
M
M
Sakurai
H
H
D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D002109:Caffeic Acids / Q000494:pharmacology*; D002726:Chlorogenic Acid / Q000494:pharmacology; D002934:Cinnamates / Q000494:pharmacology; D053630:Depsides; D004578:Electron Spin Resonance Spectroscopy; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology*; D006821:Hyaluronoglucosaminidase / Q000037:antagonists & inhibitors; D017665:Hydroxyl Radical / Q000378:metabolism; D015471:Leukemia, Basophilic, Acute / Q000201:enzymology / Q000473:pathology; D017705:Lignans; D051381:Rats; D013481:Superoxides / Q000378:metabolism; D014407:Tumor Cells, Cultured; D001619:beta-N-Acetylhexosaminidases / Q000037:antagonists & inhibitors; D000097123:Rosmarinic Acid
D018926:Anti-Allergic Agents; D002109:Caffeic Acids; D002726:Chlorogenic Acid; D002934:Cinnamates; D053630:Depsides; D004791:Enzyme Inhibitors; D016166:Free Radical Scavengers; D006821:Hyaluronoglucosaminidase; D017665:Hydroxyl Radical; D017705:Lignans; D013481:Superoxides; D001619:beta-N-Acetylhexosaminidases; D000097123:Rosmarinic Acid; C115102:rabdosiin