title: [Malignant course of a ganglioglioma: case report].
abstract: We present the case of a 8-years-old boy, admitted with a history of headache, nausea and vomiting. Cerebral angiography showed a non-vascular mass on frontal lobe. The patient underwent craniotomy and the lesion was removed. Neuropathological study revealed that the tumor was a ganglioglioma. The patient received pos-operative radiotherapy. On follow-up, 16 years after, a computed tomographic scan showed a recurrence of the tumor, and a second surgery revealed a glioblastoma multiform. Gangliogliomas are rare tumors of the central nervous system containing neoplastic ganglion cells and low grade neoplastic glial cells. The malignant degeneration occurs only in the glial component, so the prognosis of these tumors is related to the grade of that component.
authors.affiliation: Departamento de Patologia, Faculdade de Ciências Médicas, Pontifícia Universidade Católica de Campinas, Brasil.
authors.forename: J F
authors.initials: JF
authors.lastname: Araújo
authors.forename: M R
authors.initials: MR
authors.lastname: Souza
authors.forename: A
authors.initials: A
authors.lastname: Sperlescu
authors.forename: R J
authors.initials: RJ
authors.lastname: Balbo
mesh_terms: D000708:Anaplasia; D001932:Brain Neoplasms / Q000473:pathology*; D002648:Child; D005500:Follow-Up Studies; D018303:Ganglioglioma / Q000473:pathology*; D005909:Glioblastoma / Q000473:pathology; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local; D014057:Tomography, X-Ray Computed