title: Interleukin-1 alpha producing synovial sarcoma with prolonged fever: a case report.
abstract: The patient had a synovial sarcoma of the monophasic fibrous type accompanied by prolonged spike fever. Wide excision of the tumor resulted in the disappearance of her fever. The tumor cells showed interleukin-1 alpha (IL-1 alpha) expression immunohistochemically. IL-1 alpha cDNA was detected in the tumor by RT-PCR, the sequences of which were identical with those of normal human IL-1 alpha molecules. These results indicated that IL-1 alpha, one of the fever-inducing cytokines, was expressed by sarcoma cells in the present case, which were thought to be a causative factor of the fever.
authors.affiliation: Department of Orthopedic Surgery, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Osaka
authors.forename: Y
authors.initials: Y
authors.lastname: Fujimoto
authors.forename: H
authors.initials: H
authors.lastname: Yamazaki
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: S
authors.initials: S
authors.lastname: Sawada
authors.forename: N
authors.initials: N
authors.lastname: Hayashi
mesh_terms: D000368:Aged; D018076:DNA, Complementary / Q000032:analysis; D005260:Female; D005334:Fever / Q000209:etiology*; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis* / Q000235:genetics; D016133:Polymerase Chain Reaction; D013584:Sarcoma, Synovial / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology
chemical_list: D018076:DNA, Complementary; D007375:Interleukin-1