title: Can capnography detect bronchial flap-valve expiratory obstruction?
abstract: OBJECTIVE
  We have previously shown in a mechanical lung model [1] that bronchial flap-valve expiratory obstruction results in sequential lung expiration, best detected by prolonged and low magnitude tracheal expired flow (V) from the obstructed lung. However, the normal expiratory resistance of clinical ventilation circuits might also generate prolonged, low value exhaled V, that could be confused with bronchial flap-valve obstruction. We reasoned that bronchial flap-valve obstruction would also cause sequential CO2 unloading from each lung and result in a biphasic tracheal capnogram.
  
  
  METHODS
  To test this hypothesis, we ventilated (VT, 650 ml; f, 10 br/min) a dual mechanical test lung, with each side connected to a separate alcohol-burning chamber. An airway adapter-monitor system measured airway V, P, PCO2, and FO2. The circumference of the diaphragm in a respiratory one-way valve was trimmed to generate unidirectional resistance to expiratory V. Measurement sequences were repeated after this flap-valve was interposed in the left "main-stem bronchus."
  
  
  CONCLUSIONS
  During moderate or severe left bronchial flap-valve obstruction, left bronchial V was delayed so that the left lung anatomical dead space (devoid of CO2) mixed with normal right exhalate to depress the expiratory upstroke or early plateau of the tracheal capnogram. During severe obstruction, decreased perfusion of the left lung caused lower alveolar PCO2. Then, prolonged low V from the left bronchus also resulted in depression of the end of the tracheal alveolar plateau. In general, the low magnitude of bronchial V from the obstructed lung limited its effect on the tracheal capnogram and the best marker of sequential lung emptying during bronchial flap-valve obstruction may be late exhaled V without reduction in total tidal volume.
authors.affiliation: Department of Anesthesiology, University of California-Irvine, UCI Medical Center, Orange 92868, USA.
authors.forename: P H
authors.initials: PH
authors.lastname: Breen
mesh_terms: D000402:Airway Obstruction / Q000175:diagnosis* / Q000503:physiopathology; D001980:Bronchi / Q000503:physiopathology*; D019296:Capnography / Q000379:methods*; D002245:Carbon Dioxide / Q000032:analysis*; D006801:Humans; D008961:Models, Structural; D008991:Monitoring, Physiologic; D010092:Oximetry; D010366:Peak Expiratory Flow Rate; D012123:Pulmonary Ventilation / Q000502:physiology
chemical_list: D002245:Carbon Dioxide