title: Hepatic veno-occlusive disease in a case of polymyositis associated with thrombotic thrombocytopenic purpura/hemolytic uremic syndrome.
abstract: A 50-year-old woman was treated with prednisolone for polymyositis. During the therapy, thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) occurred. Neither plasma infusion nor plasma exchange could relieve the clinical manifestations of TTP/HUS. Moreover, massive ascites appeared and worsened her condition. She died approximately one year after the diagnosis of polymyositis. The autopsy revealed centri-lobular hepatic necrosis and nonthrombotic obliteration of hepatic small veins. The diagnosis of hepatic veno-occlusive disease (VOD) was made. It was suspected that common factors other than cytoreductive therapy had damaged the endothelium and caused TTP/HUS and VOD in a case of polymyositis.
authors.affiliation: Department of Internal Medicine, Toyama City Hospital, Toyama.
authors.forename: Y
authors.initials: Y
authors.lastname: Ishida
authors.forename: M
authors.initials: M
authors.lastname: Utikoshi
authors.forename: M
authors.initials: M
authors.lastname: Kurosaki
authors.forename: K
authors.initials: K
authors.lastname: Ohta
authors.forename: T
authors.initials: T
authors.lastname: Chujo
authors.forename: S
authors.initials: S
authors.lastname: Aoyama
authors.forename: K
authors.initials: K
authors.lastname: Ohsawa
authors.forename: K
authors.initials: K
authors.lastname: Saito
authors.forename: H
authors.initials: H
authors.lastname: Yokoyama
authors.forename: S
authors.initials: S
authors.lastname: Ohta
mesh_terms: D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000150:complications* / Q000209:etiology / Q000628:therapy; D006504:Hepatic Veno-Occlusive Disease / Q000150:complications* / Q000209:etiology / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D010951:Plasma Exchange; D017285:Polymyositis / Q000150:complications* / Q000188:drug therapy; D011239:Prednisolone / Q000009:adverse effects; D011697:Purpura, Thrombotic Thrombocytopenic / Q000150:complications* / Q000209:etiology / Q000628:therapy
chemical_list: D000893:Anti-Inflammatory Agents; D011239:Prednisolone