title: The ecotoxicity and the biodegradability of lactic acid, alkyl lactate esters and lactate salts.
abstract: The ecotoxicity of lactic acid, its alkyl esters and selected metal salts was studied experimentally with the micro alga Selenastrum capricornutum, the crustacean Daphnia magna and the fish species Brachydanio rerio and Pimephales promelas. In addition, the biodegradation of lactate esters was also studied. The aim of the study was to provide predicted environmental data for additional alkyl homologues and metal salts. The ecotoxicity data are evaluated by means of Structure Activity Relations (SAR), using literature data on a non-polar narcotic mechanism of toxicity as a baseline for comparison. Lactate salts were evaluated by comparison to the toxicity of the metal ion. For the fish and D. magna, it was evident that methyl, ethyl, propyl and to a lesser extent butyl lactate were slightly more toxic in comparison to baseline non-polar narcotic toxicity data. The toxicity tests carried out with lactate-salts demonstrated clearly that the toxicity in standard tests is only determined by the associated cation and not by the lactate part. Lactic acid and its alkyl esters were degraded for more than 60% in the ready biodegradability tests and from the data presented, it is evident that the majority of alkyl lactates are readily biodegradable. The results presented in this study indicate that alkyl lactate esters show some differences in their ecotoxicity when compared to non polar narcotic compounds in but that these differences are generally small. When aquatic toxicity is considered together with their rapid tendency to biodegrade, it is concluded that lactate esters show generally favourable environmental characteristics.
authors.affiliation: Department of Environmental Toxicology, TNO Nutrition and Food Research Institute, Delft, The Netherlands.
authors.forename: C T
authors.initials: CT
authors.lastname: Bowmer
authors.forename: R N
authors.initials: RN
authors.lastname: Hooftman
authors.forename: A O
authors.initials: AO
authors.lastname: Hanstveit
authors.forename: P W
authors.initials: PW
authors.lastname: Venderbosch
authors.forename: N
authors.initials: N
authors.lastname: van der Hoeven
mesh_terms: D000818:Animals; D001673:Biodegradation, Environmental; D000460:Chlorophyta / Q000187:drug effects*; D003621:Daphnia / Q000187:drug effects*; D004463:Ecology; D017753:Ecosystem; D004952:Esters / Q000633:toxicity; D007773:Lactates / Q000633:toxicity*; D019344:Lactic Acid / Q000633:toxicity*; D013329:Structure-Activity Relationship; D015027:Zebrafish / Q000502:physiology*
chemical_list: D004952:Esters; D007773:Lactates; D019344:Lactic Acid