title: Gliofibroma: mixed glial and mesenchymal tumour. Report of three cases.
abstract: Gliofibromas are rarely encountered astrocytic tumours comprising of astrocytic and benign fibroblastic components. They commonly occur in first two decades of life. However, the exact behaviour is not fully known and their histogenesis is also still debatable. We report three cases of gliofibroma in which we studied proliferative markers (MIB-1) and p53 protein expression. In these tumours, occurrence in adult life is in contrast to that reported in the literature. Depending upon the morphology and proliferative Labelling Index we classified these tumours into low grade (benign) and high grade (malignant/anaplastic).
authors.affiliation: Department of Pathology, All India Institute of Medical Sciences, New Delhi.
authors.forename: M C
authors.initials: MC
authors.lastname: Sharma
authors.forename: S
authors.initials: S
authors.lastname: Gaikwad
authors.forename: V S
authors.initials: VS
authors.lastname: Mehta
authors.forename: J
authors.initials: J
authors.lastname: Dhar
authors.forename: C
authors.initials: C
authors.lastname: Sarkar
mesh_terms: D000328:Adult; D017668:Age of Onset; D034961:Antigens, Nuclear; D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000737:chemistry / Q000473:pathology*; D005260:Female; D005350:Fibroma / Q000737:chemistry / Q000473:pathology*; D005910:Glioma / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D034961:Antigens, Nuclear; D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D009687:Nuclear Proteins; D016159:Tumor Suppressor Protein p53