title: Delayed cerebral radionecrosis with a high uptake of 11C-methionine on positron emission tomography and 201Tl-chloride on single-photon emission computed tomography.
abstract: A 47-year-old woman, who 2.5 years previously had undergone resection of a malignant astrocytoma of the left temporal lobe followed by radiotherapy, was found to have a mass in the left frontal lobe. This showed high uptake of thallium-201 (201Tl) on single-photon emission computed tomography and 11C-methionine on positron-emission tomography, suggesting recurrent tumour. Histological examination of the resected lesion, however, revealed it to be radionecrosis. This case thus illustrates a diagnostic pitfall in the use of these investigations for distinguishing radionecrosis from recurrent malignant glioma.
authors.affiliation: Department of Neurosurgery, Hachisuga Hospital, Munakata, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tashima
authors.forename: T
authors.initials: T
authors.lastname: Morioka
authors.forename: S
authors.initials: S
authors.lastname: Nishio
authors.forename: S
authors.initials: S
authors.lastname: Hachisuga
authors.forename: M
authors.initials: M
authors.lastname: Fukui
authors.forename: M
authors.initials: M
authors.lastname: Sasaki
mesh_terms: D000328:Adult; D001254:Astrocytoma / Q000532:radiotherapy; D001921:Brain / Q000000981:diagnostic imaging* / Q000528:radiation effects; D001927:Brain Diseases / Q000000981:diagnostic imaging* / Q000209:etiology; D001932:Brain Neoplasms / Q000532:radiotherapy; D002250:Carbon Radioisotopes; D005260:Female; D006801:Humans; D008715:Methionine; D011832:Radiation Injuries / Q000000981:diagnostic imaging*; D019275:Radiopharmaceuticals; D013702:Temporal Lobe; D013794:Thallium Radioisotopes; D013997:Time Factors; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D013794:Thallium Radioisotopes; C086242:carbon-11 methionine; D008715:Methionine