title: Statistical analysis of half-tetrads.
abstract: Half-tetrads, where two meiotic products from a single meiosis are recovered together, arise in different forms in a variety of organisms. Closely related to ordered tetrads, half-tetrads yield information on chromatid interference, chiasma interference, and centromere positions. In this article, for different half-tetrad types and different marker configurations, we derive the relations between multilocus half-tetrad probabilities and multilocus ordered tetrad probabilities. These relations are used to obtain equality and inequality constraints among multilocus half-tetrad probabilities that are imposed by the assumption of no chromatid interference. We illustrate how to apply these results to study chiasma interference and to map centromeres using multilocus half-tetrad data.
authors.affiliation: Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520, USA. hongyu.zhao@yale.edu
authors.forename: H
authors.initials: H
authors.lastname: Zhao
authors.forename: T P
authors.initials: TP
authors.lastname: Speed
mesh_terms: D000818:Animals; D002842:Chromatids; D003627:Data Interpretation, Statistical; D005819:Genetic Markers; D000455:Medicago sativa / Q000235:genetics; D008957:Models, Genetic; D014337:Trout / Q000235:genetics
chemical_list: D005819:Genetic Markers