Localization of the neurokinin 1 (NK-1) receptor in the human antrum and duodenum.
A newly available antibody to the neurokinin-1 receptor (NK-1r) has made it possible to determine the distribution of the NK-1r receptor in human tissue. In the present study the distribution of the NK-1r and substance P have been determined in the human antrum and duodenum by immunocytochemistry. The NK-1r was present on myenteric and submucosal neurons and nerve fibers of the gastro-enteric nervous system. In addition, the receptor was present on spindle-shaped cells in the circular muscle layer, endothelial cells and a population of mucosal cells. In the submucosal plexus NK-1r immunoreactive neurons were surrounded by substance P containing fibers. These results indicate an extensive cellular expression of the NK-1r in the human antrum and duodenum.
Smith
V C
VC
Department of Physiology, University of British Columbia, Vancouver, Canada.
Sagot
M A
MA
Couraud
J Y
JY
Buchan
A M
AM
D000818:Animals; D000906:Antibodies; D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D004386:Duodenum / Q000166:cytology* / Q000294:innervation; D005753:Gastric Mucosa / Q000166:cytology* / Q000294:innervation; D006168:Guinea Pigs; D006801:Humans; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000166:cytology* / Q000294:innervation; D009197:Myenteric Plexus / Q000166:cytology*; D009474:Neurons / Q000166:cytology*; D011706:Pyloric Antrum / Q000166:cytology / Q000294:innervation; D018040:Receptors, Neurokinin-1 / Q000032:analysis*
D000906:Antibodies; D000911:Antibodies, Monoclonal; D018040:Receptors, Neurokinin-1