title: High body fatness, but not low fat-free mass, predicts disability in older men and women: the Cardiovascular Health Study.
abstract: Using data from the Cardiovascular Health Study, we studied the relation between body composition (fat mass and fat-free mass, assessed by bioelectrical impedance) and self-reported, mobility-related disability (difficulty walking or stair climbing) in 2714 women and 2095 men aged 65-100 y. In a cross-sectional analysis at baseline (1989-1990), disability was reported by 26.5% of the women and 16.9% of the men. A positive association was observed between fat mass and disability. The odds ratio for disability in the highest quintile of fat mass was 3.04 (95% CI: 2.18, 4.25) for women and 2.77 (95% CI: 1.82, 4.23) for men compared with those in the lowest quintile. Low fat-free mass was not associated with a higher prevalence of disability. In a longitudinal analysis among persons not reporting disability at baseline, 20.3% of the women and 14.8% of the men reported disability 3 y later. Fat mass at baseline was predictive of disability 3 y later, with odds ratios of 2.83 (95% CI: 1.80, 4.46) for women and 1.72 (95% CI: 1.03, 2.85) for men in the highest quintile of fat. The increased risk was not explained by age, physical activity, chronic disease, or other potential confounders. Low fat-free mass was not predictive of disability. The results showed that high body fatness is an independent predictor of mobility-related disability in older men and women. These findings suggest that high body fatness in old age should be avoided to decrease the risk of disability.
authors.affiliation: National Institute on Aging, Epidemiology, Demography, and Biometry Program, Bethesda, MD 20892, USA.
authors.forename: M
authors.initials: M
authors.lastname: Visser
authors.forename: J
authors.initials: J
authors.lastname: Langlois
authors.forename: J M
authors.initials: JM
authors.lastname: Guralnik
authors.forename: J A
authors.initials: JA
authors.lastname: Cauley
authors.forename: R A
authors.initials: RA
authors.lastname: Kronmal
authors.forename: J
authors.initials: J
authors.lastname: Robbins
authors.forename: J D
authors.initials: JD
authors.lastname: Williamson
authors.forename: T B
authors.initials: TB
authors.lastname: Harris
mesh_terms: D000273:Adipose Tissue; D000368:Aged; D000369:Aged, 80 and over; D001823:Body Composition; D003430:Cross-Sectional Studies; D004185:Disability Evaluation; D005260:Female; D015577:Geriatric Assessment; D006306:Health Surveys; D006801:Humans; D008297:Male; D009765:Obesity / Q000150:complications*; D011237:Predictive Value of Tests; D016138:Walking