title: Right ventricular function in orthotopic total atrioventricular heart transplantation.
abstract: BACKGROUND
  Total orthotopic heart transplantation was recently introduced into clinical practice as an alternative technique of orthotopic heart transplantation, adding bicaval and left and right pulmonary vein anastomoses to pulmonary artery and ascending aorta connection (total technique). The conventional technique (ventricular transplantation with atrioplasty) is compared with the total technique with particular emphasis on right ventricular performance.
  
  
  METHODS
  Forty-eight mongrel dogs (23 to 31 kg) were used for 12 total and 12 standard orthotopic heart transplantations. Right ventricular (RV) function and atrial systole were analyzed with the use of micromanometry, sonomicrometry, and ultrasonic flow probes (preload-independent RV recruitable stroke work, RVPRSW). Fourier analysis was used to calculate RV power and pulmonary vascular impedance.
  
  
  RESULTS
  There was no significant difference in cardiac ischemic and bypass times between the two groups. After transplantation, sinus rhythm was preserved after all total transplantations and after only one standard transplantation; no significant hemodynamic differences were observed. RVPRSW in the total group was conserved after transplantation; however, RVPRSW decreased by 39% (+/-8, p < .05) in the standard group. There was also a significant decrease in the rate of RV filling in the standard group after transplantation, suggesting decreased right atrial function. Pulmonary vascular impedance and RV power output were not significantly different after transplantation between the two groups.
  
  
  CONCLUSIONS
  Total atrioventricular transplantation is a feasible alternative and conserves normal sinus rhythm. Ischemic and bypass times were not significantly different when the superior vena cava anastomosis is performed last after the release of the aortic cross-clamp. The insignificant decrease in the rate of RV filling with the use of the total technique suggests conserved RV diastolic function after transplantation with less decreased RV function in the total group.
authors.affiliation: Department of General and Cardiothoracic Surgery, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: H B
authors.initials: HB
authors.lastname: Bittner
authors.forename: E P
authors.initials: EP
authors.lastname: Chen
authors.forename: S W
authors.initials: SW
authors.lastname: Kendall
authors.forename: S S
authors.initials: SS
authors.lastname: Biswas
authors.forename: R D
authors.initials: RD
authors.lastname: Davis
authors.forename: P
authors.initials: P
authors.lastname: Van Trigt
mesh_terms: D000818:Animals; D004285:Dogs; D006321:Heart / Q000502:physiology*; D006334:Heart Function Tests; D016027:Heart Transplantation / Q000009:adverse effects / Q000379:methods*; D006352:Heart Ventricles; D017202:Myocardial Ischemia / Q000209:etiology