(E)-5-(2'-bromovinyl)-2'-deoxyuridine inhibition of macropodid herpesvirus 1 in vitro.
Herpesviruses have caused the death of kangaroos and wallabies in European and North American zoos. Eight antiherpetic purine or pyrmidine nucleoside compounds were tested in plaque reduction neutralization tests for in vitro inhibition of macropodid herpesvirus 1, a virus that has been associated with illness in captive macropods in Australia. The virus was most susceptible to inhibition by (E)-5-(2'-bromovinyl)-2'-deoxyuridine (BVDU) and 5'-iodo-2'-deoxycytidine. Because BVDU effectively inhibits macropodid herpesvirus 2 in vitro, it may be the drug of choice for experimental therapy in herpesvirus infections in captive macropodids.
Smith
G A
GA
Queensland Agricultural Biotechnology Centre, Queensland Department of Primary Industries, University of Queensland, St. Lucia, Australia.
Whalley
J M
JM
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001973:Bromodeoxyuridine / Q000031:analogs & derivatives* / Q000494:pharmacology; D002460:Cell Line; D006564:Herpesviridae / Q000187:drug effects* / Q000254:growth & development; D006566:Herpesviridae Infections / Q000662:veterinary* / Q000821:virology; D008394:Marsupialia / Q000821:virology*; D008826:Microbial Sensitivity Tests / Q000662:veterinary; D010948:Viral Plaque Assay / Q000662:veterinary
D000998:Antiviral Agents; C020235:brivudine; D001973:Bromodeoxyuridine