title: Cisapride enhances the effect of partial posterior fundoplication on esophageal peristalsis in GERD patients with poor esophageal contractility.
abstract: Partial posterior fundoplication improves esophageal peristalsis in patients with gastroesophageal reflux disease (GERD) associated with poor esophageal body function. The aim of this study was to investigate whether postoperative administration of cisapride enhances the effect of surgery on esophageal peristalsis. Laparoscopic partial posterior fundoplication was performed on 34 consecutive GERD patients with poor esophageal body motility. These patients were randomized in groups without and with postoperative treatment with cisapride 20 mg twice daily for six months. Esophageal manometry was performed preoperatively and six months following surgery. Esophageal body function improved significantly following partial posterior fundoplication without or with postoperative treatment with cisapride. However, this effect was more pronounced in the group of patients receiving cisapride. Partial posterior fundoplication combined with postoperative treatment with cisapride should be the therapy of choice in GERD patients with poor esophageal body motility.
authors.affiliation: Department of Surgery, University of Innsbruck, Austria.
authors.forename: G J
authors.initials: GJ
authors.lastname: Wetscher
authors.forename: K
authors.initials: K
authors.lastname: Glaser
authors.forename: T
authors.initials: T
authors.lastname: Wieschemeyer
authors.forename: M
authors.initials: M
authors.lastname: Gadenstätter
authors.forename: P
authors.initials: P
authors.lastname: Klingler
authors.forename: A
authors.initials: A
authors.lastname: Klingler
authors.forename: R A
authors.initials: RA
authors.lastname: Hinder
mesh_terms: D000328:Adult; D000368:Aged; D020117:Cisapride; D004947:Esophagus / Q000187:drug effects* / Q000503:physiopathology*; D005260:Female; D018662:Fundoplication / Q000379:methods; D005764:Gastroesophageal Reflux / Q000188:drug therapy* / Q000503:physiopathology; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D010277:Parasympathomimetics / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology*; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D005765:Gastrointestinal Agents; D010277:Parasympathomimetics; D010880:Piperidines; D020117:Cisapride