Entropy maps characterize drug effects on brain dynamics in Alzheimer's disease.
Non-linear quantifiers of brain electrical dynamics (entropy maps computed from the degradation of temporal forecasting of EEG signals) were studied in relation to drug treatment of Alzheimer's disease. A placebo condition was compared to three drug doses (50, 100 and 200 mg). A significant general effect of the drug was found when compared to placebo and specific contrasts between placebo and each of the three drug doses only reveal a significant entropy increase for the highest dose. These effects were localized bilaterally in fronto-temporal areas and support changes in the dynamics of the cerebral structures involved in memory processes.
Pezard
L
L
Unité de Neurosciences Cognitives and Imagerie Cérébrale, LENA (CNRS UPR 640), Paris, France.
Martinerie
J
J
Varela
F J
FJ
Bouchet
F
F
Guez
D
D
Derouesné
C
C
Renault
B
B
D000161:Acoustic Stimulation; D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000503:physiopathology*; D001921:Brain / Q000187:drug effects / Q000503:physiopathology*; D001931:Brain Mapping; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography / Q000187:drug effects*; D019277:Entropy; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D010919:Placebos
D010919:Placebos