title: [Pheochromocytoma manifesting as toe necrosis].
abstract: BACKGROUND
  Cutaneous manifestations of pheochromocytoma other than sweating, and facial pallor during paroxysmal episodes of hypertension are exceptional.
  
  
  METHODS
  We observed partial necrosis of the fourth toes which revealed pheochromocytoma.
  
  
  CONCLUSIONS
  Signs of peripheral vascular disease are uncommon during the course of pheochromocytoma. Only four cases have been reported in the literature. Occurrence of distal necrosis in combination with hypertension and palpable pulses is suggestive of pheochromocytoma requiring assay of urinary catecholamines. The pathogenic mechanisms of necrosis would be vasospasm of cutaneous vessels due to excessive plasmatic catecholamine levels and thrombocytosis as an aggravating factor.
authors.affiliation: Service de Dermatologie-Phlébologie, Hôpital Saint-Eloi, Montpellier.
authors.forename: D
authors.initials: D
authors.lastname: Bessis
authors.forename: O
authors.initials: O
authors.lastname: Dereure
authors.forename: A
authors.initials: A
authors.lastname: Le Quellec
authors.forename: A J
authors.initials: AJ
authors.lastname: Ciurana
authors.forename: J J
authors.initials: JJ
authors.lastname: Guilhou
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D000328:Adult; D002395:Catecholamines / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000209:etiology; D008297:Male; D009336:Necrosis; D016491:Peripheral Vascular Diseases / Q000209:etiology* / Q000473:pathology; D010673:Pheochromocytoma / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D013922:Thrombocytosis / Q000209:etiology; D014034:Toes / Q000098:blood supply*; D014057:Tomography, X-Ray Computed
chemical_list: D002395:Catecholamines