title: Dopaminergic stimulation in unilateral neglect.
abstract: OBJECTIVE
  To explore the hypothesis that dopaminergic circuits play a part in the premotor components of the unilateral neglect syndrome, the effects of acute dopaminergic stimulation in patients with neglect were studied.
  
  
  METHODS
  Two tasks were evaluated before and after subcutaneous administration of apomorphine and placebo: a circle crossing test and a test of target exploration (a modified version of the bell test), performed both in perceptual (counting) and in perceptual-motor (pointing) conditions.
  
  
  METHODS
  Four patients with left neglect.
  
  
  RESULTS
  After dopaminergic stimulation, a significant improvement was found compared with placebo administration and baseline evaluation, in the performance of the two tests. Three of the patients had a more marked improvement in the perceptual-motor condition (pointing) of the task than the perceptual condition (counting).
  
  
  CONCLUSIONS
  The findings suggest that dopaminergic neuronal networks may mediate, in different ways, both perceptive and premotor components of the unilateral neglect syndrome.
authors.affiliation: Department of Psychology, University of Turin, and Istituto Nazionale Neurologico C Besta, Milan, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Geminiani
authors.forename: G
authors.initials: G
authors.lastname: Bottini
authors.forename: R
authors.initials: R
authors.lastname: Sterzi
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D001058:Apomorphine; D001288:Attention / Q000502:physiology*; D002544:Cerebral Infarction / Q000175:diagnosis / Q000503:physiopathology*; D004292:Dominance, Cerebral / Q000502:physiology*; D004298:Dopamine / Q000502:physiology*; D018491:Dopamine Agonists; D005260:Female; D006429:Hemiplegia / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000503:physiopathology*; D009483:Neuropsychological Tests; D009949:Orientation / Q000502:physiology; D011597:Psychomotor Performance / Q000502:physiology
chemical_list: D018491:Dopamine Agonists; D001058:Apomorphine; D004298:Dopamine