Platelet proteins as autoantibody targets in idiopathic thrombocytopenic purpura.
Idiopathic thrombocytopenic purpura (ITP), caused by autoantibodies directed against certain platelet antigens, is the most common entity of the immune thrombocytopenias. ITP is an acquired disorder and can affect both children and adults. However, the clinical syndromes of ITP are distinct between children and adults. Childhood (acute) ITP characteristically is acute in onset, occurs within 1-2 weeks of an infection, usually of viral origin, resolves spontaneously within 6 months. Adult (chronic) ITP has an insidious onset and rarely resolves spontaneously. Over the last decade considerable new information has accumulated as to the pathophysiological mechanisms of immune thrombocytopenias. In addition, most of the knowledge on this disorder has been obtained from studies of adult patients with chronic ITP. The present work gives an updated overview of the platelet autoantigens and the molecular immunological reactions in ITP.
Wadenvik
H
H
Department of Internal Medicine, Sahlgrenska University Hospital, University of Göteborg, Sweden.
Stockelberg
D
D
Hou
M
M
D000208:Acute Disease; D000328:Adult; D001323:Autoantibodies / Q000276:immunology*; D001792:Blood Platelets / Q000276:immunology*; D018955:CD36 Antigens; D002648:Child; D002908:Chronic Disease; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D019038:Platelet Glycoprotein GPIb-IX Complex; D010980:Platelet Membrane Glycoproteins; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000276:immunology* / Q000503:physiopathology / Q000821:virology; D011956:Receptors, Cell Surface; D014335:Tropomyosin / Q000276:immunology
D001323:Autoantibodies; D018955:CD36 Antigens; D007074:Immunoglobulin G; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D019038:Platelet Glycoprotein GPIb-IX Complex; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface; D014335:Tropomyosin; C032193:glycoprotein receptor GPIb-IX