Phylogenetically interrelated ETS genes, ETV1, ERM and E1A-F locate on different chromosomes.
ETV1, ERM and E1A-F are members of the multigene ETS domain containing a class of transcription factors, first identified in the genome of the avian retrovirus E26. Based upon extensive homology between these genes within their ETS domain (96% identity each other), these three genes comprise a distinct sub-family of ETS genes as a human PEA3 sub-family. By analyzing somatic cell hybrid segregating human chromosomes, the genes encoding ETV1, ERM and E1A-F were localized to human chromosome 7, 3 and 17, respectively. Fluorescence in situ hybridization confirmed these assignments and allowed mapping of the genes to 7p22 (ETV1), 3q29 (ERM) and 17q12 (E1A-F). These results suggest the ancestral PEA3 gene may have duplicated first, then dispersed to other chromosomal locations.
Jeon
I S
IS
Department of Experimental Oncology, St Jude Children's Research Hospital, Memphis, TN, USA.
Shapiro
D N
DN
D017500:Adenovirus E1A Proteins / Q000235:genetics*; D000818:Animals; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D002893:Chromosomes, Human, Pair 3; D002897:Chromosomes, Human, Pair 7; D004268:DNA-Binding Proteins / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells; D017404:In Situ Hybridization, Fluorescence; D005810:Multigene Family; D010802:Phylogeny; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D050783:Proto-Oncogene Proteins c-ets; D012377:Rodentia; D014157:Transcription Factors / Q000235:genetics*
D017500:Adenovirus E1A Proteins; D004268:DNA-Binding Proteins; C079853:ETV4 protein, human; C086680:ETV5 protein, human; D011518:Proto-Oncogene Proteins; D050783:Proto-Oncogene Proteins c-ets; D014157:Transcription Factors