Conformationally constrained 1,3-diamino ketones: a series of potent inhibitors of the cysteine protease cathepsin K.
Marquis
R W
RW
Departments of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, USA.
Yamashita
D S
DS
Ru
Y
Y
LoCastro
S M
SM
Oh
H J
HJ
Erhard
K F
KF
DesJarlais
R L
RL
Head
M S
MS
Smith
W W
WW
Zhao
B
B
Janson
C A
CA
Abdel-Meguid
S S
SS
Tomaszek
T A
TA
Levy
M A
MA
Veber
D F
DF
D001665:Binding Sites; D056657:Cathepsin K; D002403:Cathepsins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D018360:Crystallography, X-Ray; D015853:Cysteine Proteinase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D003959:Diamines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008958:Models, Molecular; D008968:Molecular Conformation; D018716:Molecular Mimicry; D010455:Peptides / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D015853:Cysteine Proteinase Inhibitors; D003959:Diamines; D007659:Ketones; D010455:Peptides; D002403:Cathepsins; D056657:Cathepsin K