The effect of flavonoids on ofloxacin-induced mutagenicity in Euglena gracilis.
The antimutagenicity of 14 naturally occurring flavonoids (20 mumol/l) on ofloxacin (43 mumol/l and 86 mumol/l)-induced bleaching (mutagenicity) was studied in Euglena gracilis. The flavonoids chrysin, techtochrysin, chrysin-5-methylether galangin, galangin-5-methylether, pinocembrin and pinobanksin possess considerable antimutagenic properties against ofloxacin-induced bleaching of E. gracilis. Apigenin and isalpinin had only weak antimutagenic potency. Pinobanksin-5-methylether and pinobanksin-3-acetate showed very weak or no antimutagenic effect. However, kempferol, quercetin-3-methylether and quercetin-3,3'-dimethylether showed co-mutagenic or no antimutagenic effect depending on the concentration of ofloxacin. Two possible modes of action of the flavonoids on ofloxacin-induced bleaching of E. gracilis are discussed.
Krizková
L
L
Institute of Molecular and Subcellular Biology, Faculty of Science, Comenius University, Bratislava, Slovak Republic.
Nagy
M
M
Polónyi
J
J
Ebringer
L
L
D000818:Animals; D016587:Antimutagenic Agents / Q000737:chemistry / Q000494:pharmacology*; D002736:Chloroplasts / Q000187:drug effects; D005056:Euglena gracilis / Q000187:drug effects* / Q000235:genetics*; D044950:Flavanones; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D009153:Mutagens / Q000633:toxicity*; D015242:Ofloxacin / Q000633:toxicity*
D016587:Antimutagenic Agents; D044950:Flavanones; D005419:Flavonoids; D009153:Mutagens; C037032:galangin; C043561:chrysin; C108261:pinobanksin; C016063:pinocembrin; D015242:Ofloxacin