title: Effect of exercise on acid-base status and ventilatory kinetics.
abstract: The normal respiratory responses and changes in acid base status in twenty normal height, weight and age matched subjects were studied; using Auto Spiro AS 300 spirometer for ventilatory parameters and NOVA stat profile 3 analyser for gas analysis. Each subject performed a progressive incremental treadmill exercise by Bruce protocol to their symptom limited maximum. Minute ventilation (VE), tidal volume (VT) and frequency of respiration (f) increased significantly (P<0.001). Acidosis occured following exercise as pH of arterialized venous blood declined significantly (P<0.05). Gas analysis of arterialized venous blood showed a rise in pO2 (P<0.001) and a fall in pCO2 (P<0.001). Recovery of acid base status as well as gaseous pressure in blood did not occur after 10 min. Expired gas pCO2 declined significantly (P<0.05) and pO2 increase significantly (P<0.05). These pressures returned to resting levels 10 min after exercise. Thus in normal young adults heavy exercise caused an increment in ventilatory kinetics producing hyperpnoea which recovers after a rest of 10 min. Acidosis stimulates the respiratory centre to cause hyperventilation which tries to meet the added metabolic demands of strenuous exercise.
authors.affiliation: Department of Physiology, Govt. Medical College, Nagpur.
authors.forename: M S
authors.initials: MS
authors.lastname: Phatak
authors.forename: G A
authors.initials: GA
authors.lastname: Kurhade
authors.forename: S B
authors.initials: SB
authors.lastname: Kaore
authors.forename: G C
authors.initials: GC
authors.lastname: Pradhan
mesh_terms: D000138:Acidosis; D000328:Adult; D002245:Carbon Dioxide; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008168:Lung / Q000502:physiology*; D008297:Male; D010100:Oxygen; D012123:Pulmonary Ventilation; D012129:Respiratory Function Tests; D013990:Tidal Volume
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen