title: Antiprotozoal properties of 16,17-dihydrobrachycalyxolide from Vernonia brachycalyx.
abstract: Extracts of the leaves from Vernonia brachycalyx showed in vitro activity against Plasmodium falciparum and promastigotes of Leishmania major. The germacrane dilactone 16,17-dihydrobrachycalyxolide (1) which was previously isolated from the aerial parts of the plant was shown to be the major antiplasmodial principle. An X-ray crystallographic analysis established the absolute configuration and some signals in the NMR spectra were reassigned. 16,17-Dihydrobrachycalyxolide (1) elicited a strong antiplasmodial and antileishmanial activity but also a high toxicity against human lymphocytes.
authors.affiliation: Phytochemistry Department, National Museums of Kenya, Nairobi.
authors.forename: H A
authors.initials: HA
authors.lastname: Oketch-Rabah
authors.forename: S
authors.initials: S
authors.lastname: Brøgger Christensen
authors.forename: K
authors.initials: K
authors.lastname: Frydenvang
authors.forename: S F
authors.initials: SF
authors.lastname: Dossaji
authors.forename: T G
authors.initials: TG
authors.lastname: Theander
authors.forename: C
authors.initials: C
authors.lastname: Cornett
authors.forename: W M
authors.initials: WM
authors.lastname: Watkins
authors.forename: A
authors.initials: A
authors.lastname: Kharazmi
authors.forename: E
authors.initials: E
authors.lastname: Lemmich
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D018320:Leishmania major / Q000187:drug effects*; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects*; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D010936:Plant Extracts; D018515:Plant Leaves; D010946:Plants, Medicinal; D045788:Sesquiterpenes, Germacrane / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: C114747:16,17-dihydrobrachycalyxolide; D000981:Antiprotozoal Agents; D010936:Plant Extracts; D045788:Sesquiterpenes, Germacrane