Peptidomimetic design.
Major discoveries have been made of new type-I and type-III peptidomimetic inhibitors of peptide-derived systems. Innovative reversible inhibitors of cysteine proteases and renin, and additional examples of peptidomimetic inhibitors of interleukin-1 beta-converting enzyme, neutral endopeptidase, herpes simplex virus protease, thrombin, HIV protease, Ras farnesyltransferase, the RGD motif, Factor Xa and various aspartic proteases have been discovered.
Ripka
A S
AS
Department of Chemistry and School of Pharmacy, University of Wisconsin-Madison 53706, USA.
Rich
D H
DH
D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry; D005544:Forecasting; D018716:Molecular Mimicry; D010455:Peptides; D011487:Protein Conformation
D004791:Enzyme Inhibitors; D010455:Peptides; D016282:Aspartic Acid Endopeptidases