[Polymorphism of the HLA-DRB1 04 gene in inhabitants of Tuva].
Data on the HLA-DRB1 04 gene typing among Tuvinians from Kyzyl are presented. Experiments were conducted by using the hybridization of allele-specific oligonucleotides with the amplified fragments of high molecular-weight DNA and reverse hybridization. The HLA-DRB1 0401 allele was most frequent among DR4-positive individuals. The HLA-DRB1 0405 and HLA-DRB1 0403 alleles were found at somewhat lower frequencies. In one individual, the rare HLA-DRB1 0410 subtype differing from HLA-DRB1 0405 subtype by the substitution of glycine for valine in codon 86 was detected.
Sartakova
M L
ML
Institute of Clinical Immunology, Russian Academy of Medical Sciences, Novosibirsk, Russia.
Konenkov
V I
VI
Smit
A
A
Lamazshaa
A M
AM
Kara-Mongush
S I
SI
Alekseenko
S N
SN
D000293:Adolescent; D000328:Adult; D000483:Alleles; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006650:Histocompatibility Testing; D006801:Humans; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D011110:Polymorphism, Genetic; D012800:Siberia
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C553505:HLA-DRB1*04:01 antigen