[Effects of carvedilol, a sympatholytic, in experimental alloxan diabetes in laboratory rats].
A possible effect of the sympatholytic carvedilol on alloxan-induced diabetes mellitus in the laboratory rat was examined in experiments. The animals were divided into a group treated with carvedilol in a single daily dose of 10mg/kg in 1 ml of diluting solution i.p and the control group which received only diluting solution in the pertinent amount. The values of malondialdehyde and glucose in the serum, diuresis and total losses of sugar in the urine within 24 hours were estimated and histopathological examination of the kidneys of the treated and control groups was performed. The results show an effect of the tested dose of the drug, primarily in the region the proximal renal tubule.
Bartosíková
L
L
Farmaceutická fakulta VFU, Brno.
Necas
J
J
Pavlícek
V
V
Kuchticková
S
S
Frána
P
P
Zavadilová
R
R
Husek
K
K
D018674:Adrenergic Antagonists / Q000494:pharmacology*; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002227:Carbazoles / Q000494:pharmacology*; D000077261:Carvedilol; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism* / Q000473:pathology; D007668:Kidney / Q000473:pathology; D008054:Lipid Peroxides / Q000097:blood; D011412:Propanolamines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D018674:Adrenergic Antagonists; D001786:Blood Glucose; D002227:Carbazoles; D008054:Lipid Peroxides; D011412:Propanolamines; D000077261:Carvedilol