title: Blood and plasma selenium levels and GSH-Px activities in patients with arterial hypertension and chronic heart disease.
abstract: The purpose of this study was to examine the relationship between arterial hypertension (HTN), chronic heart disease (CHD), and selenium (Se) status. Blood and plasma Se concentrations and Se-dependent GSH-Px activities were determined in 40 patients (HTN = 20; CHD = 20) and 17 healthy volunteers aged 41 to 66 years. Whole blood and plasma Se concentrations were significantly lower in the patients with HTN (19.1% and 26.3%, respectively) and CHD (33.1% and 29.4%, respectively) compared with the values obtained in the controls. The hypertensive patients had lower plasma Se-GSH-Px (26.7%), and those with CHD had both lower whole blood (19.5%) and plasma Se-GSH-Px activities (30.2%). A significant positive correlation between plasma Se-GSH-Px activity and ejection fraction (EF) was found in patients with CHD. There were significant correlations between plasma and whole blood Se concentration, plasma Se concentration and Se-GSH-Px activity, and whole blood Se and Se-GSH-Px activity. Our results showed that hypertensive patients and those with CHD had lower Se levels compared with controls. We conclude that low Se content might be a risk factor for development of HTN and CHD.
authors.affiliation: Department of Physiology, Faculty of Veterinary Medicine, Belgrade, Yugoslavia.
authors.forename: M B
authors.initials: MB
authors.lastname: Mihailović
authors.forename: D M
authors.initials: DM
authors.lastname: Avramović
authors.forename: I B
authors.initials: IB
authors.lastname: Jovanović
authors.forename: O J
authors.initials: OJ
authors.lastname: Pesut
authors.forename: D P
authors.initials: DP
authors.lastname: Matić
authors.forename: V J
authors.initials: VJ
authors.lastname: Stojanov
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005979:Glutathione Peroxidase / Q000097:blood*; D006331:Heart Diseases / Q000097:blood* / Q000201:enzymology*; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000201:enzymology*; D008875:Middle Aged; D012643:Selenium / Q000097:blood*
chemical_list: D005979:Glutathione Peroxidase; D012643:Selenium