GB virus C/hepatitis G virus infection among Colombian native Indians.
To elucidate the prevalence of GB virus C/hepatitis G virus (GBV-C/HGV) infection in Colombian native Indians, serum GBV-C/HGV RNA was assayed in 163 native Indians and 67 members of the general population in Colombia. The native Indians (males:females = 40:123) and the members of the general population (males:females = 20:47) were tested by reverse transcription-semi-nested polymerase chain reaction. Of the 163 native Indians, 10 (6.1%) were positive for GBV-C/HGV RNA, compared with one (1.5%) of 67 from the general population. All Indians were negative for hepatitis B surface antigen and antibody to hepatitis C virus. Of 10 Indians with GBV-C/HGV RNA, the genotype of nine subjects was the Asian type. These data indicated that 1) the prevalence of GBV-C/HGV RNA in Colombian native Indians is high, and 2) GBV-C/HGV was probably brought from Asia and inherited for generations in some native Indian groups.
Tanaka
Y
Y
Second Department of Medicine, Nagoya City University Medical School, Nagoya, Japan.
Mizokami
M
M
Orito
E
E
Ohba
K
K
Nakano
T
T
Kato
T
T
Kondo
Y
Y
Ding
X
X
Ueda
R
R
Sonoda
S
S
Tajima
K
K
Miura
T
T
Hayami
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D001483:Base Sequence; D002648:Child; D003105:Colombia / Q000453:epidemiology; D016384:Consensus Sequence; D004279:DNA, Viral / Q000737:chemistry; D005260:Female; D018067:Flaviviridae / Q000145:classification / Q000235:genetics*; D005838:Genotype; D006525:Hepatitis, Viral, Human / Q000453:epidemiology*; D006801:Humans; D007199:Indians, South American; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D015995:Prevalence; D012367:RNA, Viral / Q000097:blood* / Q000235:genetics; D016415:Sequence Alignment
D004279:DNA, Viral; D012367:RNA, Viral