title: Toxin-mediated streptococcal and staphylococcal disease.
abstract: After several decades of seemingly decreasing virulence, streptococcal and staphylococcal infections have reemerged as a major source of morbidity and mortality. Within the past 2 decades, not only have well-established diseases such as rheumatic fever begun to reappear. but also many new entities, such as toxic shock syndrome, streptococcal toxic shock syndrome, recurrent toxin-mediated perineal erythema, and recalcitrant erythematous desquamating disorder have been described. Central to the renewed importance of these bacteria has been the production of circulating toxins, which often function as superantigens in causing the clinical manifestations, morbidity and mortality associated with these diseases.
authors.affiliation: Department of Medicine, University of Medicine and Dentistry of New Jersey--Robert Wood Johnson Medical School at Camden, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Manders
mesh_terms: D001427:Bacterial Toxins; D005260:Female; D006801:Humans; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome; D012772:Shock, Septic; D013203:Staphylococcal Infections; D013207:Staphylococcal Skin Infections; D013211:Staphylococcus aureus / Q000472:pathogenicity; D013290:Streptococcal Infections; D013291:Streptococcus / Q000472:pathogenicity; D013297:Streptococcus pyogenes / Q000472:pathogenicity; D013301:Streptolysins; D018089:Superantigens; D014774:Virulence
chemical_list: D001427:Bacterial Toxins; D013301:Streptolysins; D018089:Superantigens