Recall and recognition memory in patients with focal frontal, temporal lobe and diencephalic lesions.
Patients with frontal, temporal lobe, or diencephalic lesions were compared with healthy controls on measures of recall and recognition memory for word lists. Exposure times were titrated to match recognition memory scores 30 s after the end of word-list presentation as closely as possible. Using this technique, we failed to find a disproportionate impairment in recall memory in either the frontal lobe lesion patients or in the amnesic (temporal lobe and diencephalic) patients, compared with healthy controls. Consistent with this finding, performance on these tasks showed highly significant correlations with anterograde memory quotients (despite the titration procedure), but not with executive/frontal function tasks. On the other hand, the frontal lobe lesion group showed disproportionate benefit in the recall of semantically categorised words, compared with unrelated words. This may indicate an impairment in retrieval or access, compared with the amnesic (temporal lobe and diencephalic) patients, and/or an inability to organise their learning of unrelated words spontaneously, compared with healthy controls.
Kopelman
M D
MD
Neuropsychiatry and Memory Disorders Clinic, Division of Psychiatry and Psychology, United Medical and Dental Schools of Guy's and St Thomas's Hospital, London, UK. m.kopelman@umds.ac.uk
Stanhope
N
N
D000328:Adult; D000368:Aged; D000425:Alcohol Amnestic Disorder / Q000523:psychology; D001930:Brain Injuries / Q000000981:diagnostic imaging / Q000473:pathology / Q000523:psychology*; D003071:Cognition / Q000502:physiology*; D004027:Diencephalon / Q000000981:diagnostic imaging / Q000293:injuries* / Q000473:pathology; D018792:Encephalitis, Viral / Q000523:psychology; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000293:injuries* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D011939:Mental Recall / Q000502:physiology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000293:injuries* / Q000473:pathology; D014055:Tomography, Emission-Computed