title: Skeletal cell stresses and bone adaptation.
abstract: There is no tissue in which mechanical stresses have been studied in more detail than the skeletal system, this focus arising primarily because bone plays a clear structural role in the body. However, the hypothesis that the skeleton represents an optimally designed structure has contributed remarkably little to our understanding of the development and adaptive capabilities of bone tissue. Recent investigations on the consequences of mechanical, hydrostatic, and electrical stresses on the cells of bone tissue have served to redirect the discussion of bone modeling and remodeling processes. These studies have refocused attention on the importance of chronic low-level dynamic stresses in mediating the physiologic response of bone tissue. Important recent observations suggest that an approach premised on the self-organizational properties of bone tissue may lead to significant improvements in our understanding and control of bone morphologic development, adaptation, and healing.
authors.affiliation: Musculoskeletal Research Laboratory, Health Sciences Center, State University of New York, Stony Brook 11794-8181, USA. kmcleod@ccmail.sunysb.edu
authors.forename: K J
authors.initials: KJ
authors.lastname: McLeod
authors.forename: C T
authors.initials: CT
authors.lastname: Rubin
authors.forename: M W
authors.initials: MW
authors.lastname: Otter
authors.forename: Y X
authors.initials: YX
authors.lastname: Qin
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001842:Bone and Bones / Q000166:cytology / Q000502:physiology*; D004553:Electric Conductivity; D006801:Humans; D012212:Rheology; D013314:Stress, Mechanical