Comparative FISH mapping of mouse and rat homologues of twenty-five human X-linked genes.
We constructed a comparative cytogenetic map of 25 functional genes in mouse and rat X chromosomes by direct R-banding fluorescence in situ hybridization. Nineteen and 22 out of the 25 genes, which have been mapped on the human X chromosome, were newly localized to mouse and rat X chromosomes, respectively. Twenty-two additional genes were integrated in the rat-mouse-human comparative map of the X chromosome in this study. Comparison of the gene order indicated the presence of four chromosome segments with conserved linkage homology between mouse and rat X chromosomes, suggesting that a minimum of four chromosomal inversion events occurred between mouse and rat X chromosomes during the evolution of the two species. Four chromosome segments with conserved linkage homology were found between human and rat X chromosomes.
Kuroiwa
A
A
Laboratory of Animal Genetics, School of Agricultural Sciences, Nagoya University, Nagoya, Japan.
Watanabe
T
T
Hishigaki
H
H
Takahashi
E
E
Namikawa
T
T
Matsuda
Y
Y
D000818:Animals; D002871:Chromosome Banding; D002874:Chromosome Mapping; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D051379:Mice / Q000235:genetics*; D051381:Rats / Q000235:genetics*; D014960:X Chromosome