title: Frequent somatic mutations in serine/threonine kinase 11/Peutz-Jeghers syndrome gene in left-sided colon cancer.
abstract: We analyzed somatic mutation and loss of heterozygosity (LOH) in the serine/threonine kinase 11 (STK11)/Peutz-Jeghers syndrome gene in 49 colorectal tumors in three different stages of a dysplasia-carcinoma sequence. We detected LOH in 10 of 19 (52.6%) informative colorectal cancers at loci D19S886 and/or D19S883, but no LOH was observed in 25 informative adenomas. We detected a total of 9 somatic mutations [7 of 13 (53.8%) left-sided colon cancers and 2 of 7 (28.6%) left-sided adenomas with high-grade dysplasia], but no mutations were detected in right-sided colon tumors. Of the nine mutations, one was a frameshift mutation (the same mutation detected in Peutz-Jeghers syndrome family previously), and the other eight were missense mutations. This results indicate that STK11 is a tumor suppressor gene and that genetic changes of STK11 play an important role in left-sided colon cancer carcinogenesis.
authors.affiliation: Department of Pathology and Cancer Research Institute, Catholic University Medical College, Seoul, Korea.
authors.forename: S M
authors.initials: SM
authors.lastname: Dong
authors.forename: K M
authors.initials: KM
authors.lastname: Kim
authors.forename: S Y
authors.initials: SY
authors.lastname: Kim
authors.forename: M S
authors.initials: MS
authors.lastname: Shin
authors.forename: E Y
authors.initials: EY
authors.lastname: Na
authors.forename: S H
authors.initials: SH
authors.lastname: Lee
authors.forename: W S
authors.initials: WS
authors.lastname: Park
authors.forename: N J
authors.initials: NJ
authors.lastname: Yoo
authors.forename: J J
authors.initials: JJ
authors.lastname: Jang
authors.forename: C Y
authors.initials: CY
authors.lastname: Yoon
authors.forename: J W
authors.initials: JW
authors.lastname: Kim
authors.forename: S Y
authors.initials: SY
authors.lastname: Kim
authors.forename: Y M
authors.initials: YM
authors.lastname: Yang
authors.forename: S H
authors.initials: SH
authors.lastname: Kim
authors.forename: C S
authors.initials: CS
authors.lastname: Kim
authors.forename: J Y
authors.initials: JY
authors.lastname: Lee
mesh_terms: D000091162:AMP-Activated Protein Kinase Kinases; D001483:Base Sequence; D002888:Chromosomes, Human, Pair 19; D003110:Colonic Neoplasms / Q000235:genetics*; D016147:Genes, Tumor Suppressor; D006801:Humans; D019656:Loss of Heterozygosity; D008969:Molecular Sequence Data; D009154:Mutation; D010580:Peutz-Jeghers Syndrome / Q000235:genetics*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*
chemical_list: D017346:Protein Serine-Threonine Kinases; C109790:STK11 protein, human; D000091162:AMP-Activated Protein Kinase Kinases