Solitary fibrous tumor of the liver with CD 34 positivity and hypoglycemia.
We report a new case of solitary fibrous tumor (SFT) of the liver, an extremely rare neoplasm. Including the present case no more than ten cases are reported in the English-language literature. To date there is no definite proof of the origin of this tumor. Both mesothelial and fibroblas-tic genesis has been postulated. The monoclonal antibody CD 34 has recently been used for the characterization of SFT. SFT would appear to be histogenetically related to a CD 34 - positive fibroblastic stem cell. A 61-year-old woman was admitted to our department with epigastric and right hypochondriac pain, weight loss, and hypoglycemia. Ultrasonography and computed tomography demonstrated a large heterogeneous mass in the right hepatic lobe. A right hepatectomy was performed. The tumor weighed 2850 g and microscopic section revealed a peculiar random pattern, the so-called patternless pattern of spindle tumor cells separated by abundant thick collagen bands. The tumor presented a number of highly cellular areas composed of plump spindle cell with hyperchromatic nuclei and rare mitotic figures. Ninety percent of the neoplastic cells displayed strong immunoreactivity for CD 34/My 10. The postoperative course was uneventful and the patient is alive and well without recurrence 6 years after surgery.
Guglielmi
A
A
First Department of General Surgery, Verona, University Medical School, Piazzale Stefani 1, 37126 Verona, Italy.
Frameglia
M
M
Iuzzolino
P
P
Martignoni
G
G
De Manzoni
G
G
Laterza
E
E
Veraldi
G F
GF
Girlanda
R
R
D000792:Angiography; D018952:Antigens, CD34 / Q000378:metabolism*; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000150:complications; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D008875:Middle Aged; D018218:Neoplasms, Fibrous Tissue / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D014057:Tomography, X-Ray Computed
D018952:Antigens, CD34