title: Cell and molecular biology of the pars tuberalis of the pituitary.
abstract: The pars tuberalis of the adenohypophysis is mainly composed of a special type of endocrine cells, pars tuberalis-specific cells, lining the primary capillary plexus of the hypophysial portal system. Dense expression of melatonin receptors and marked changes in morphological appearance, production pattern, and secretory activity during annual cycle show that these cells are highly sensitive to changes in photoperiod. This leads to the hypothesis that the pars tuberalis is involved in the transmission of photoperiodic stimuli to endocrine targets. Several investigations support the theory that pars tuberalis-specific cells are multipotential cells exerting a modulatory influence on the secretory activity of the pars distalis. Specifically, there is accumulating evidence that seasonal modulation of prolactin secretion, independent of hypothalamic input, is due to melatonin-regulated activity of pars tuberalis-specific cells. The exact nature of secretory products and their effects within neuroendocrine regulation, however, remain rather enigmatic. Accordingly, molecular mechanisms regulating gene expression under the influence of photoperiod, respectively, circulating melatonin levels are still incomplete. Recent cloning of melatonin receptor genes and new data on intracellular signal transduction will probably lead to new insights on melatonin action and pars tuberalis-specific cell physiology.
authors.affiliation: Institute of Anatomy, AG Molecular Neuroendocrinology, Westfälische Wilhelms-Universität, Münster, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Wittkowski
authors.forename: J
authors.initials: J
authors.lastname: Bockmann
authors.forename: M R
authors.initials: MR
authors.lastname: Kreutz
authors.forename: T M
authors.initials: TM
authors.lastname: Böckers
mesh_terms: D000818:Animals; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D008550:Melatonin / Q000037:antagonists & inhibitors / Q000502:physiology; D008854:Microscopy, Electron; D008967:Molecular Biology; D010507:Periodicity; D017440:Photoperiod; D010903:Pituitary Gland, Anterior / Q000166:cytology* / Q000254:growth & development / Q000502:physiology*; D010908:Pituitary Hormones, Anterior / Q000235:genetics / Q000502:physiology; D011956:Receptors, Cell Surface / Q000235:genetics / Q000502:physiology; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000502:physiology; D044094:Receptors, Melatonin; D012098:Reproduction / Q000502:physiology; D013972:Thyrotropin / Q000737:chemistry / Q000235:genetics / Q000502:physiology
chemical_list: D010908:Pituitary Hormones, Anterior; D011956:Receptors, Cell Surface; D018160:Receptors, Cytoplasmic and Nuclear; D044094:Receptors, Melatonin; D013972:Thyrotropin; D008550:Melatonin