Negative association between asthma and variants of CC16(CC10) on chromosome 11q13 in British and Japanese populations.
The gene encoding Clara cell-derived inflammatory molecule CC16 has been cited as a candidate gene for atopic asthma on chromosome 1lq13. A genetic association study was performed with variants of the CC16 gene on chromosome 1lq13 in relation to asthma in British (n=275) and Japanese (n=300) populations. No significant association was found between asthma and CC16 genotypes, irrespective of atopic status in these two populations. These data suggest that CC16 might not be the major locus for asthma on 11q13.
Gao
P S
PS
Osler Chest Unit, Churchill Hospital, Oxford, UK.
Mao
X Q
XQ
Kawai
M
M
Enomoto
T
T
Sasaki
S
S
Tanabe
O
O
Yoshimura
K
K
Shaldon
S R
SR
Dake
Y
Y
Kitano
H
H
Coull
P
P
Shirakawa
T
T
Hopkin
J M
JM
D001249:Asthma / Q000145:classification / Q000235:genetics*; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007564:Japan; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D011506:Proteins / Q000235:genetics*; D012016:Reference Values; D018570:Risk Assessment; D006113:United Kingdom; D014598:Uteroglobin
D011506:Proteins; C556389:SCGB1A1 protein, human; D014598:Uteroglobin