title: The prevalence and related symptomatology of Helicobacter pylori in children with recurrent abdominal pain.
abstract: The aim of the study was to assess and compare the IgG seroprevalence of H. pylori in children with recurrent abdominal pain with healthy children and to investigate the related symptoms. IgG antibodies against low-molecular weight H. pylori antigens were assessed in 438 children with recurrent abdominal pain and in 91 healthy controls. Sera with an ELISA unit-value above the cut-off level were confirmed by Western immunoblot. Only seropositive children with recurrent abdominal pain were examined by an oesophago-gastro-duodenoscopy. Symptomatology was recorded according to the localization of the abdominal pain, presence of pyrosis, nocturnal pain, relation of pain to meals and bowel irregularities. The seroprevalence was 21% (95% CI: 17-25%) in the children with recurrent abdominal pain and 10% (95% CI: 5-18%) in the healthy controls (p = 0.30). In seropositive children with RAP H. pylori was found in 46/66 by culture and histology. The presence of H. pylori was significantly associated with active or inactive chronic gastritis. The presence of H. pylori was associated with both parents being born in a country with a high prevalence and a low social class. Helicobacter pylori-positive children had more often pain related to meals than the H. pylori-negative children. No differences among the two groups were seen according to the levels of haemoglobin, leucocytes, thrombocytes, weight and height. In conclusion, the seroprevalence of H. pylori is comparable in children with recurrent abdominal pain and healthy children. No specific symptomatology was seen in H. pylori-positive children with RAP.
authors.affiliation: Department of Paediatrics, Hvidovre Hospital, University of Copenhagen, Denmark.
authors.forename: V
authors.initials: V
authors.lastname: Wewer
authors.forename: L P
authors.initials: LP
authors.lastname: Andersen
authors.forename: A
authors.initials: A
authors.lastname: Paerregaard
authors.forename: A B
authors.initials: AB
authors.lastname: Gernow
authors.forename: J P
authors.initials: JP
authors.lastname: Hart Hansen
authors.forename: P
authors.initials: P
authors.lastname: Matzen
authors.forename: P A
authors.initials: PA
authors.lastname: Krasilnikoff
mesh_terms: D015746:Abdominal Pain / Q000453:epidemiology / Q000209:etiology*; D000293:Adolescent; D000704:Analysis of Variance; D000907:Antibodies, Bacterial / Q000097:blood*; D000942:Antigens, Bacterial / Q000276:immunology; D015153:Blotting, Western; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D003718:Denmark / Q000453:epidemiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005756:Gastritis / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology; D016481:Helicobacter Infections / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D015995:Prevalence; D012008:Recurrence; D016036:Seroepidemiologic Studies; D018709:Statistics, Nonparametric
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D007074:Immunoglobulin G