title: S-100 protein-positive dendritic cells in follicular lesions of the thyroid.
abstract: Little is known about the role of S-100 protein-positive dendritic cells in follicular lesions of the thyroid. In 36 cases of adenomatous goitre, 18 cases of follicular adenoma, and 7 cases of follicular carcinoma, we investigated the incidence and distribution of S-100 protein-positive dendritic cells using immunohistochemical staining. Four cases (10.5%) of adenomatous goitre, five cases (31.3%) of follicular adenoma, and 6 cases (85.7%) of follicular carcinoma contained S-100 protein-positive dendritic cells in the subcapsular area and/or the hyalinized stroma. Dendritic cells in the subcapsular area were observed only in lesions with thick capsules and not those with thin capsules. In most cases of follicular carcinoma, + + to + + + of the dendritic cells was seen together with a few lymphocytes and fibroblasts in the subcapsular areas. In contrast, cases of adenomatous goitre and follicular adenoma showed only a few dendritic cells without any inflammatory cells. Dendritic cells in follicular thyroid lesions may play some role in capsular formation or may be a secondary phenomenon due to capsular formation.
authors.affiliation: Department of Pathology, Kawasaki Medical School, Kurashiki, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hirokawa
authors.forename: M
authors.initials: M
authors.lastname: Shimizu
authors.forename: T
authors.initials: T
authors.lastname: Manabe
authors.forename: H
authors.initials: H
authors.lastname: Sonoo
authors.forename: T
authors.initials: T
authors.lastname: Harada
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000737:chemistry / Q000473:pathology; D000236:Adenoma / Q000737:chemistry / Q000473:pathology; D000328:Adult; D000368:Aged; D002452:Cell Count; D003713:Dendritic Cells / Q000737:chemistry* / Q000473:pathology*; D005260:Female; D006044:Goiter, Nodular / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009418:S100 Proteins / Q000032:analysis*; D013964:Thyroid Neoplasms / Q000737:chemistry / Q000473:pathology*
chemical_list: D009418:S100 Proteins