title: Pharmacokinetic study in dogs and monkeys after single intravenous and oral administrations of [14C]-ITF-296.
abstract: Pharmacokinetics of [14C]-ITF-296 and its metabolites, ITF-1124 and ITF-1577, were studied in dogs and monkeys after a single intravenous (2.5 mg/kg) and oral (10 mg/kg) administration. Radioactivity was measured by LSC while unchanged drug and its metabolites in plasma were assayed by an HPLC-UV method. The absorption of [14C]-ITF-296 after oral administration is practically complete both in dogs and in monkeys. The determination of unchanged drug and its metabolites shows quite a similar profile in dogs and monkeys for ITF-296 and ITF-1124 and a different time-course for ITF-1577. Elimination of radioactivity occurs mainly in urine (namely 70-80%) for both species and the recovery of the dose (higher than 90%) takes place up to 96 h after both treatments.
authors.affiliation: Istituto di Ricerche Biomediche A. Marxer, RBM S.p.A., Colleretto Giacosa (TO), Italy.
authors.forename: C
authors.initials: C
authors.lastname: Giachetti
authors.forename: M
authors.initials: M
authors.lastname: Bertolino
authors.forename: S
authors.initials: S
authors.lastname: Canali
authors.forename: E
authors.initials: E
authors.lastname: Lombardini
authors.forename: M V
authors.initials: MV
authors.lastname: Monzani
authors.forename: A
authors.initials: A
authors.lastname: Sala
authors.forename: G
authors.initials: G
authors.lastname: Zanolo
mesh_terms: D000042:Absorption; D000284:Administration, Oral; D000818:Animals; D048588:Benzoxazines; D002250:Carbon Radioisotopes; D004285:Dogs; D007275:Injections, Intravenous; D007511:Ischemia / Q000517:prevention & control; D008252:Macaca fascicularis; D008297:Male; D009566:Nitrates / Q000097:blood / Q000493:pharmacokinetics*; D010078:Oxazines / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D048588:Benzoxazines; D002250:Carbon Radioisotopes; D009566:Nitrates; D010078:Oxazines; C091726:sinitrodil