title: Interrelationships among disablement concepts.
abstract: BACKGROUND
  Understanding interrelationships among disablement concepts is critical to the design of future disability treatment and prevention interventions.
  
  
  METHODS
  This study uses cross-sectional data to examine the relationships among physiologic impairments, functional limitations, and disability in a moderately disabled sample of 207 community-dwelling older adults.
  
  
  RESULTS
  As hypothesized, the data revealed statistically significant curvilinear relationships of upper and lower extremity strength and balance with mobility in this older sample. Multivariate analyses further clarified the hypothesized causal mechanism among the disablement concepts by demonstrating that most of the association of muscle strength and balance with disability was through the intermediary role of mobility limitations.
  
  
  CONCLUSIONS
  The findings from this study highlight the value of clinical trials that focus on prevention or treatment of mobility limitations as a means of preventing disability; our findings underscore the need for future research that examines the effects of other variables believed to influence disablement in late life.
authors.affiliation: Sargent College of Health and Rehabilitation Sciences, Boston University, USA. ajette@bu.edu
authors.forename: A M
authors.initials: AM
authors.lastname: Jette
authors.forename: S F
authors.initials: SF
authors.lastname: Assmann
authors.forename: D
authors.initials: D
authors.lastname: Rooks
authors.forename: B A
authors.initials: BA
authors.lastname: Harris
authors.forename: S
authors.initials: S
authors.lastname: Crawford
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D006233:Persons with Disabilities; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009132:Muscles / Q000502:physiology*