title: A kit formulation for preparation of [(111)In]In-DTPA-folate, a folate-receptor-targeted radiopharmaceutical.
abstract: A kit formulation has been developed for convenient, routine compounding of (111)In-labeled In(III)-DTPA-Folate, an investigational radiopharmaceutical for targeting tumor-associated folate receptors. The kit consists of the DTPA-Folate conjugate in sodium citrate solution, from which [(111)In]In-DTPA-Folate can be rapidly and reliably compounded by the addition of aqueous [(111)In]In(III)-chloride.
authors.affiliation: Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907-1333, USA.
authors.forename: C J
authors.initials: CJ
authors.lastname: Mathias
authors.forename: M A
authors.initials: MA
authors.lastname: Green
mesh_terms: D002352:Carrier Proteins / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D058973:Folate Receptors, GPI-Anchored; D005492:Folic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D007205:Indium Radioisotopes / Q000737:chemistry*; D007553:Isotope Labeling / Q000379:methods*; D004369:Pentetic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000378:metabolism; D011956:Receptors, Cell Surface
chemical_list: D002352:Carrier Proteins; C108951:DTPA folate; D058973:Folate Receptors, GPI-Anchored; D007205:Indium Radioisotopes; D019275:Radiopharmaceuticals; D011956:Receptors, Cell Surface; D004369:Pentetic Acid; D005492:Folic Acid