A gene therapy approach to treatment of autoimmune disease.
New insights into the underlying mechanisms for the development of autoimmune diseases in humans and various animal models continue to increase with our understanding of factors that drive polarization of T helper (Th) responses and tolerance. This information has led to the development of new treatment strategies, including oral tolerance clinical trails and the use of altered peptide ligands in animal models. These approaches have shown some promise and provided additional insight into the disease processes. The use of gene therapy in many disease states continues to increase. We are starting to see the application of gene therapy in chronic diseases in humans. Gene therapy has been used in several animal models of autoimmune disease with promising preliminary results. In this article, an overview will be provided for the use of gene therapy in autoimmune disease.
Seroogy
C M
CM
Department of Medicine, Stanford University School of Medicine, CA 94305-5111, USA. cseroogy@leland.stanford.edu
Fathman
C G
CG
D000818:Animals; D000941:Antigens / Q000008:administration & dosage / Q000276:immunology; D001327:Autoimmune Diseases / Q000628:therapy*; D004195:Disease Models, Animal; D015316:Genetic Therapy; D005822:Genetic Vectors; D006801:Humans; D018417:Th1 Cells / Q000276:immunology; D014780:Viruses / Q000235:genetics
D000941:Antigens