Superior efficacy of liposomal amphotericin B with prolonged circulation in blood in the treatment of severe candidiasis in leukopenic mice.
In leukopenic mice with severe systemic candidiasis, single-dose treatment (5 mg of amphotericin B [AMB]/kg of body weight) with long-circulating polyethylene glycol-coated AMB liposomes (PEG-AMB-LIP) resulted in zero mortality and a significant reduction in the number of viable Candida albicans in the kidney, whereas 70% mortality was seen in mice treated with five daily doses of AmBisome (5 mg of AMB/kg . day). When the first of five daily doses of AmBisome was combined with a single low dose of Fungizone (0.1 mg of AMB/kg), the efficacy was equal to that of PEG-AMB-LIP.
van Etten
E W
EW
Department of Medical Microbiology and Infectious Diseases, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands. vanetten@kmic.fgg.eur.nl
Snijders
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SV
van Vianen
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Bakker-Woudenberg
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IA
D000666:Amphotericin B / Q000008:administration & dosage* / Q000097:blood; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage*; D002177:Candidiasis / Q000188:drug therapy*; D004337:Drug Carriers; D007970:Leukopenia / Q000150:complications*; D008081:Liposomes; D051379:Mice
D000935:Antifungal Agents; D004337:Drug Carriers; D008081:Liposomes; D000666:Amphotericin B