Muricoreacin and murihexocin C, mono-tetrahydrofuran acetogenins, from the leaves of Annona muricata.
Bioactivity-directed fractionation of the leaves of Annona muricata L. (Annonaceae) resulted in the isolation of two new Annonaceous acetogenins, muricoreacin (1) and murihexocin C (2). Compounds 1 and 2 showed significant cytotoxicities among six human tumor cell lines with selectivities to the prostate adenocarcinoma (PC-3) and pancreatic carcinoma (PACA-2) cell lines.
Kim
G S
GS
Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47906, USA.
Zeng
L
L
Alali
F
F
Rogers
L L
LL
Wu
F E
FE
Sastrodihardjo
S
S
McLaughlin
J L
JL
D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology; D000230:Adenocarcinoma / Q000188:drug therapy; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D005233:Fatty Alcohols / Q000302:isolation & purification / Q000494:pharmacology; D005663:Furans / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D007783:Lactones / Q000302:isolation & purification* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D010190:Pancreatic Neoplasms / Q000188:drug therapy; D010936:Plant Extracts / Q000302:isolation & purification* / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011471:Prostatic Neoplasms / Q000188:drug therapy; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014197:Trees / Q000737:chemistry; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D005233:Fatty Alcohols; D005663:Furans; D007783:Lactones; D010936:Plant Extracts; C112079:isomurisolenin; C114846:muricoreacin; C114845:murihexocin C; D015107:4-Butyrolactone