title: Does the narrow operating field in perineal radical prostatectomy lead to more positive surgical margins?
abstract: OBJECTIVE
  To assess the risk of leaving cancer-positive surgical margins in the perineal approach for radical prostatectomy as compared to the retropubic approach.
  
  
  METHODS
  Seventy-six patients with clinically organ-confined prostate cancer (stage T1-2 NoMo) underwent radical prostatectomy. The 57 patients who underwent retropubic prostatectomy were compared to 19 patients in whom the perineal approach was undertaken. The two groups were compared for pre-operative PSA levels, clinical stage, biopsy Gleasson score, and any correlation between pre- and post-operative stage and grade of the disease and rate of cancer-positive surgical margins.
  
  
  RESULTS
  Although there were no significant differences in the rate of organ-confined diseases and specimen Gleasson score in the two groups, the rate of positive surgical margins in the perineal approach was significantly lower (15.7 vs 29.8%) and the rate of extracapsular disease with negative margins was significantly higher (15.7 vs 7%).
  
  
  CONCLUSIONS
  The narrow surgical field in the perineal approach for radical prostatectomy does not pose a higher risk for positive surgical margins and it might be the procedure of choice in stage T1C prostate cancer with a Gleasson score of below 7.
authors.affiliation: Department of Urology, Meir General Hospital, Kfar Saba, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Shalev
authors.forename: G
authors.initials: G
authors.lastname: Tykochinsky
authors.forename: S
authors.initials: S
authors.lastname: Richter
authors.forename: O J
authors.initials: OJ
authors.lastname: Kessler
authors.forename: I
authors.initials: I
authors.lastname: Nissenkorn
mesh_terms: D000368:Aged; D006801:Humans; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy / Q000009:adverse effects* / Q000379:methods*; D011471:Prostatic Neoplasms / Q000276:immunology / Q000473:pathology* / Q000601:surgery*
chemical_list: D017430:Prostate-Specific Antigen