The regulatory status of xylazine for use in food-producing animals in the United States.
Xylazine is commonly used in veterinary medicine as a tranquillizer or adjunct to surgical anaesthesia. Although its use is approved in companion animals and certain species of deer, xylazine remains unapproved for use in food-producing animals in the United States. This paper reviews existing toxicological and residue chemistry information on xylazine in food animals, particularly cattle, and discusses the regulatory status of the drug in the US, as well as the conclusions reached by the Joint FAO/WHO Expert Committee on Food Additives in its recent evaluation of xylazine.
Chamberlain
P L
PL
Center for Veterinary Medicine, United States Food and Drug Administration, Rockville, MD 20855, USA.
Brynes
S D
SD
D000316:Adrenergic alpha-Agonists / Q000032:analysis / Q000493:pharmacokinetics / Q000633:toxicity*; D000814:Aniline Compounds / Q000032:analysis / Q000493:pharmacokinetics / Q000633:toxicity; D000818:Animals; D015197:Carcinogenicity Tests; D002417:Cattle; D017277:Drug Approval; D004350:Drug Residues / Q000032:analysis / Q000633:toxicity*; D005506:Food Contamination; D008461:Meat Products / Q000032:analysis / Q000592:standards; D008892:Milk / Q000737:chemistry; D051381:Rats; D014481:United States; D014486:United States Food and Drug Administration; D014991:Xylazine / Q000032:analysis / Q000493:pharmacokinetics / Q000633:toxicity*
D000316:Adrenergic alpha-Agonists; D000814:Aniline Compounds; D014991:Xylazine; C007766:2,6-xylidine