Clinical evaluation of the cutaneous phototoxicity of 5,10,15,20-tetra(m-hydroxyphenyl)chlorin.
The cutaneous phototoxic reaction induced by intravenous injection of 5,-10,-15,-20-tetra(m-hydroxyphenyl)chlorin (mTHPC) has been clinically evaluated in patients undergoing photodynamic therapy. These tests were performed on the backs of 23 patients with a solar simulator at various times after drug administration ranging from 5 h to 57 days. The mTHPC doses ranged from 0.1 to 0.3 mg/kg, and the illuminations lasted from 30 s up to 8 min. These tests have shown that the duration of the skin photosensitization induced after a typical therapeutic dose of mTHPC (0.15 mg/kg) is less important than with Photofrin (2 mg/kg). The level of mTHPC in the skin was also assessed in vivo and at times corresponding to the irradiations using an optical fiber-based spectrofluorometer. This study indicates that the light-induced fluorescence spectroscopy of mTHPC enables prediction of the degree of photosensitivity of the skin.
Wagnieres
G
G
Institute of Environmental Engineering, Swiss Federal Institute of Technology, Lausanne, Switzerland. georges.wagnieres@epfl.ch
Hadjur
C
C
Grosjean
P
P
Braichotte
D
D
Savary
J F
JF
Monnier
P
P
van den Bergh
H
H
D004305:Dose-Response Relationship, Drug; D006801:Humans; D008027:Light; D008652:Mesoporphyrins / Q000633:toxicity*; D017319:Photosensitizing Agents / Q000633:toxicity*; D012867:Skin / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects; D013997:Time Factors
D008652:Mesoporphyrins; D017319:Photosensitizing Agents; C072269:temoporfin