title: Distribution of prognostically important vascular patterns across multiple levels in ciliary body and choroidal melanomas.
abstract: OBJECTIVE
  To investigate the validity of assigning patients whose eyes have been removed for ciliary body or choroidal melanoma to risk groups for metastasis based on the identification of microcirculatory patterns in one cross-section taken from the center of the tumor.
  
  
  METHODS
  Multiple levels were cut through the blocks of 15 ciliary body or choroidal melanomas until the tumor was exhausted. Each level was examined for the presence of microvascular networks and parallel vessels with cross-linking histologic features strongly associated with death from metastatic melanoma.
  
  
  RESULTS
  The central histologic section did not contain either microvascular networks or parallel vessels with cross-linking in eight tumors, nor were these patterns encountered in any of the more peripheral levels of the tumor. Seven tumors contained at least one focus of either microvascular networks or parallel vessels with cross-linking in the central histologic section. In two tumors, at least one of these patterns appeared in all histologic levels; in five tumors, at least one of these patterns appeared through multiple levels until just before the tumor was exhausted from the block (0.24 to 0.85 mm from the edge of the tumor).
  
  
  CONCLUSIONS
  This study suggests that the prognostic classification of uveal melanoma based on the histologic profile of the microcirculation may be consistent throughout the tumor depth.
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City 52242-1182, USA.
authors.forename: M G
authors.initials: MG
authors.lastname: Mehaffey
authors.forename: L M
authors.initials: LM
authors.lastname: Gardner
authors.forename: R
authors.initials: R
authors.lastname: Folberg
mesh_terms: D002830:Choroid Neoplasms / Q000098:blood supply / Q000473:pathology; D002924:Ciliary Body / Q000098:blood supply / Q000473:pathology*; D006801:Humans; D008545:Melanoma / Q000098:blood supply* / Q000473:pathology / Q000556:secondary*; D008833:Microcirculation; D011379:Prognosis; D012307:Risk Factors; D014604:Uveal Neoplasms / Q000098:blood supply / Q000473:pathology*