title: Significance of rest technetium-99m sestamibi imaging for the prediction of improvement of left ventricular dysfunction after Q wave myocardial infarction: importance of infarct location adjusted thresholds.
abstract: OBJECTIVE
  The value of rest technetium-99m (Tc-99m) sestamibi scintigraphy under oral nitrate medication to predict myocardial viability was examined in patients with chronic infarcts.
  
  
  BACKGROUND
  The value of rest Tc-99m sestamibi to predict viability in infarct regions has not been fully established because significant underestimation of viability, especially in the inferior myocardial wall, has been reported.
  
  
  METHODS
  Forty patients with Q wave myocardial infarction underwent Tc-99m sestamibi single-photon emission computed tomography under nitrate medication before revascularization of the infarct-related artery. Wall motion was quantified from paired angiograms before and 4 months after revascularization. Tracer uptake was quantified in the central infarct region identified on the angiogram.
  
  
  RESULTS
  The average Tc-99m sestamibi uptake in the central infarct region of patients with anterior infarcts and improvement of left ventricular function was significantly higher (68+/-12%, mean+/-SD) than in patients without improvement of function (40+/-14%, p < 0.02). The average Tc-99m sestamibi uptake in the central infarct region of patients with improvement of function and inferior infarcts was significantly lower (43+/-7%) than in patients with anterior infarcts (68+/-12%, p < 0.003), but was significantly higher than in patients with inferior infarction and no improvement of function (31+/-7%, p < 0.02). Using an infarct location adjusted optimal threshold (50% for anterior infarcts, 35% for inferior infarcts), Tc-99m sestamibi had a positive predictive value of 90% and a negative predictive value of 91% for improvement of left ventricular function.
  
  
  CONCLUSIONS
  Quantitative rest Tc-99m sestamibi scintigraphy after oral nitrates reliably predicts improvement of left ventricular function after revascularization if infarct location adjusted thresholds are used.
authors.affiliation: Klinik III für Innere Medizin, Köln, Germany.
authors.forename: C A
authors.initials: CA
authors.lastname: Schneider
authors.forename: E
authors.initials: E
authors.lastname: Voth
authors.forename: S
authors.initials: S
authors.lastname: Gawlich
authors.forename: F M
authors.initials: FM
authors.lastname: Baer
authors.forename: M
authors.initials: M
authors.lastname: Horst
authors.forename: H
authors.initials: H
authors.lastname: Schicha
authors.forename: E
authors.initials: E
authors.lastname: Erdmann
authors.forename: U
authors.initials: U
authors.lastname: Sechtem
mesh_terms: D000368:Aged; D005260:Female; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery; D009204:Myocardial Revascularization; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000503:physiopathology; D011379:Prognosis; D013318:Stroke Volume / Q000502:physiology; D017256:Technetium Tc 99m Sestamibi; D014022:Tissue Survival / Q000502:physiology; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery
chemical_list: D019788:Fluorodeoxyglucose F18; D017256:Technetium Tc 99m Sestamibi