title: Pathogenesis and neuroprotective treatment in Purtscher's retinopathy.
abstract: Purtscher's retinopathy is characterized by sudden visual loss in severely traumatized patients and is associated with multiple areas of superficial retinal whitening located primarily in the posterior pole. Visual outcome in Purtscher's retinopathy is variable, and there is no well-defined treatment. We report on a patient with immediate blurred vision in the right eye after a traffic accident. Ophthalmoscopy revealed multiple whitish patches scattered over the macular and peripapillary areas in the right eye. Fluorescein angiography showed multifocal retinal arteriolar occlusion in the early phase and staining of the involved retinal vessels and optic nerve head in the late phase. Indocyanine green angiography (ICG) showed rarefaction of choroidal vessels in the peripapillary area of the right eye at early phase. The late phase ICG study revealed multifocal hypofluorescent patches in the macular and peripapillary areas. Megadose steroid therapy was given with good visual response in the first 2 weeks, and the patient's vision had recovered completely when followed-up 10 months later.
authors.affiliation: Department of Ophthalmology, Taipei Veterans General Hospital, National Yang-Ming University, Taiwan, Republic of China.
authors.forename: A G
authors.initials: AG
authors.lastname: Wang
authors.forename: M Y
authors.initials: MY
authors.lastname: Yen
authors.forename: J H
authors.initials: JH
authors.lastname: Liu
mesh_terms: D000063:Accidents, Traffic; D000208:Acute Disease; D000293:Adolescent; D002574:Cervical Vertebrae / Q000293:injuries; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D007262:Infusions, Intravenous; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D012164:Retinal Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D012171:Retinal Vessels / Q000473:pathology*; D016103:Spinal Fractures / Q000150:complications; D014792:Visual Acuity
chemical_list: D018696:Neuroprotective Agents; D008775:Methylprednisolone