Cell-assembly coding in several memory processes.
The present paper discusses why the cell assembly, i.e., an ensemble population of neurons with flexible functional connections, is a tenable view of the basic code for information processes in the brain. The main properties indicating the reality of cell-assembly coding are neurons overlaps among different assemblies and connection dynamics within and among the assemblies. The former can be detected as multiple functions of individual neurons in processing different kinds of information. Individual neurons appear to be involved in multiple information processes. The latter can be detected as changes of functional synaptic connections in processing different kinds of information. Correlations of activity among some of the recorded neurons appear to change in multiple information processes. Recent experiments have compared several different memory processes (tasks) and detected these two main properties, indicating cell-assembly coding of memory in the working brain. The first experiment compared different types of processing of identical stimuli, i.e., working memory and reference memory of auditory stimuli. The second experiment compared identical processes of different types of stimuli, i.e., discriminations of simple auditory, simple visual, and configural auditory-visual stimuli. The third experiment compared identical processes of different types of stimuli with or without temporal processing of stimuli, i.e., discriminations of elemental auditory, configural auditory-visual, and sequential auditory-visual stimuli. Some possible features of the cell-assembly coding, especially "dual coding" by individual neurons and cell assemblies, are discussed for future experimental approaches.
Sakurai
Y
Y
Primate Research Institute, Kyoto University, Kanrin, 484-8506, Japan. sakurai@smtp.pri.kyoto-u.ac.jp
D000818:Animals; D001307:Auditory Perception / Q000502:physiology*; D001921:Brain / Q000502:physiology; D002450:Cell Communication; D004193:Discrimination Learning / Q000502:physiology; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D008568:Memory / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology*; D009473:Neuronal Plasticity; D051381:Rats; D009435:Synaptic Transmission; D013702:Temporal Lobe / Q000502:physiology*; D013997:Time Factors; D014796:Visual Perception / Q000502:physiology*