Effect of permeabilizing agents on antibacterial activity against a simple Pseudomonas aeruginosa biofilm.
A simple Pseudomonas aeruginosa G48 biofilm on stainless steel discs provided a useful primary screen of potentiating effects of various permeabilizing agents on antibacterial agents. Experiments with Ps. aeruginosa suspensions could not be used to predict the effects of biocides and permeabilizers on biofilms. Although antibacterial activity against biofilms was less than demonstrated in suspension tests, potentiation by some permeabilizers was still observed.
Ayres
H M
HM
Welsh School of Pharmacy, University of Wales Cardiff, UK.
Payne
D N
DN
Furr
J R
JR
Russell
A D
AD
D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D002463:Cell Membrane Permeability / Q000187:drug effects; D004357:Drug Synergism; D004492:Edetic Acid / Q000494:pharmacology*; D011122:Polyphosphates / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000254:growth & development
D000891:Anti-Infective Agents, Local; D011122:Polyphosphates; D004492:Edetic Acid