Primary malignant mixed Müllerian tumor of the vagina.
A 74-year-old woman presented with postmenopausal bleeding. Examination showed a 5.5-cm ulcerated, partly necrotic vaginal polyp arising anteriorly near the hymenal ring. Histology showed a malignant mixed Müllerian tumor (MMMT) with squamous and glandular epithelial and undifferentiated spindle cell stromal components, cytological atypia, and frequent mitoses. The tumor was closely associated with overlying vaginal intraepithelial neoplasia, grade III, from which it appeared to be arising. The patient was treated by surgical excision, followed by radiotherapy. Six months later, she developed a left supraclavicular lymph node metastasis. MMMT is a rare primary vaginal neoplasm, but, including this case, there have been at least 7 cases reported in the English language literature.
Neesham
D
D
Department of Gynecologic Oncology, Department of Pathology, Mercy Hospital for Women, Clarendon Street, East Melbourne, 3002, Australia.
Kerdemelidis
P
P
Scurry
J
J
D000368:Aged; D005260:Female; D006801:Humans; D018200:Mixed Tumor, Mullerian / Q000473:pathology*; D014625:Vaginal Neoplasms / Q000473:pathology*