Prolonged mivacurium neuromuscular block in children.
The authors report two cases of prolonged neuromuscular block after administration of mivacurium in children with previously undiagnosed plasma cholinesterase deficiency related to homozygous atypical genotype. Their anaesthetic management is described as well as determination of the phenotype of both children and their family.
Lejus
C
C
Service d'Anesthésie et de Réanimation Chirurgicale, CHR Nantes, France.
Blanloeil
Y
Y
Le Roux
N
N
Soulard
D
D
Mesguish
M
M
Burnat
P
P
Duvaldestin
P
P
Pinaud
M
M
D000762:Anesthesia Recovery Period; D000768:Anesthesia, General; D001062:Appendectomy; D002648:Child; D002802:Cholinesterases / Q000172:deficiency / Q000235:genetics; D005838:Genotype; D006801:Humans; D007546:Isoquinolines; D008297:Male; D000077590:Mivacurium; D019148:Neuromuscular Blockade; D003473:Neuromuscular Nondepolarizing Agents; D010641:Phenotype; D013997:Time Factors
D007546:Isoquinolines; D003473:Neuromuscular Nondepolarizing Agents; D000077590:Mivacurium; D002802:Cholinesterases