Ruptured de novo aneurysm induced by ethyl 2-cyanoacrylate: case report.
OBJECTIVE
We report a rare case of a ruptured de novo aneurysm induced by ethyl 2-cyanoacrylate.


METHODS
A 44-year-old woman had undergone microvascular decompression for a right-sided facial spasm. The preoperative vertebral angiogram did not show any aneurysmal dilation. The right anteroinferior cerebellar artery, which was compressing the exit zone of the facial nerve, was detached and fixed to the dura mater with ethyl 2-cyanoacrylate. Nine years later, the patient suffered a subarachnoid hemorrhage caused by the rupture of a newly developed aneurysm of the right anteroinferior cerebellar artery.


METHODS
The aneurysm was clipped 2 days after onset of the subarachnoid hemorrhage. It consisted of two bulges in the arterial wall on the proximal side of the meatal loop. One bulge was stuck to the dura mater of the pyramis by ethyl 2-cyanoacrylate, which had been used in the microvascular decompression 9 years previously.


CONCLUSIONS
This is the first reported clinical case of a de novo aneurysm induced by a cyanoacrylate adhesive. Ethyl 2-cyanoacrylate can damage the arterial wall and induce a de novo aneurysm.
Tokuda
Y
Y
Department of Neurosurgery, Shimane Prefectural Central Hospital, Japan.
Inagawa
T
T
Takechi
A
A
Inokuchi
F
F
D017542:Aneurysm, Ruptured / Q000139:chemically induced* / Q000175:diagnosis; D002533:Cerebral Angiography; D003487:Cyanoacrylates / Q000009:adverse effects* / Q000627:therapeutic use; D005152:Facial Muscles; D005260:Female; D006490:Hemostatics / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D002532:Intracranial Aneurysm / Q000139:chemically induced* / Q000175:diagnosis; D008875:Middle Aged; D013035:Spasm / Q000188:drug therapy; D014057:Tomography, X-Ray Computed; D014711:Vertebral Artery / Q000000981:diagnostic imaging
D003487:Cyanoacrylates; D006490:Hemostatics; C029054:ethyl 2-cyanoacrylate