title: [Can radioactive iodine be used in the treatment of diffuse non-toxic goiter?].
abstract: Traditional treatment modalities of diffuse nontoxic goitre are thyroid hormone suppression or surgery. When treating nodular nontoxic goitre with 131I treatment, a reduction in thyroid volume to about 50% is seen. In the present study we evaluated the effect of 131I treatment in 21 patients treated for a diffuse nontoxic goitre and followed by evaluation of thyroid volume measured by ultrasound. Thyroid volume declined in all patients from median of 66 ml (range 27-160 ml) to 21 ml (9-108 ml) over a year, a reduction of 62%. Three patients developed hypothyroidism in the follow-up period (14%), one of these had a temporary hyperthyroid fase. In conclusion, 131I treatment of diffuse nontoxic goitre reduces thyroid volume by approximately 60% within 12 months. Hypothyroidism developed in 14% during a limited follow-up period.
authors.affiliation: Endokrinologisk afdeling F, Amtssygehuset i Herlev.
authors.forename: B
authors.initials: B
authors.lastname: Nygaard
authors.forename: L
authors.initials: L
authors.lastname: Hegedüs
authors.forename: F N
authors.initials: FN
authors.lastname: Bennedbaek
authors.forename: A
authors.initials: A
authors.lastname: Veje
authors.forename: J O
authors.initials: JO
authors.lastname: Faber
authors.forename: J E
authors.initials: JE
authors.lastname: Hansen
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006042:Goiter / Q000532:radiotherapy*; D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D007457:Iodine Radioisotopes