Complexity of EGF receptor signalling revealed in Drosophila.
The multiple roles of the Drosophila epidermal growth factor receptor (EGFR) require that its activation is regulated precisely. Recent work has highlighted two important control mechanisms: the existence of multiple ligands with distinct properties and the interaction between EGFR pathway and other signalling pathways. The integration of signalling pathways into networks is beginning to be understood.
Freeman
M
M
MRC Laboratory of Molecular Biology, Cambridge, UK. mf1@mrc-lmb.cam.ac.uk
D000818:Animals; D004330:Drosophila / Q000378:metabolism*; D029721:Drosophila Proteins; D066246:ErbB Receptors / Q000378:metabolism*; D005136:Eye Proteins / Q000502:physiology; D008024:Ligands; D009419:Nerve Tissue Proteins / Q000502:physiology; D015398:Signal Transduction
D029721:Drosophila Proteins; D005136:Eye Proteins; D008024:Ligands; D009419:Nerve Tissue Proteins; C075638:aos protein, Drosophila; D066246:ErbB Receptors