title: Lung cancer patients have increased 8-hydroxydeoxyguanosine levels in peripheral lung tissue DNA.
abstract: The 8-hydroxydeoxyguanosine (8-OH-dG) levels in the peripheral parts of human lung tissues were compared between lung cancer patients (n=70) and non-cancer patient controls (n=15). An increased level of 8-OH-dG was observed in the lung cancer group, in both the adenocarcinoma and non-adenocarcinoma (mainly squamous cell carcinoma) groups, as compared to the non-cancer control group. This result suggests that reactive oxygen species are partly involved in the induction of lung carcinomas (both adenocarcinoma and non-adenocarcinoma).
authors.affiliation: Department of Environmental Oncology, Institute of Industrial Ecological Sciences, School of Medicine, University of Occupational and Environmental Health, Kitakyushu.
authors.forename: M
authors.initials: M
authors.lastname: Inoue
authors.forename: T
authors.initials: T
authors.lastname: Osaki
authors.forename: M
authors.initials: M
authors.lastname: Noguchi
authors.forename: S
authors.initials: S
authors.lastname: Hirohashi
authors.forename: K
authors.initials: K
authors.lastname: Yasumoto
authors.forename: H
authors.initials: H
authors.lastname: Kasai
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004247:DNA / Q000378:metabolism*; D004249:DNA Damage; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000032:analysis; D005260:Female; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008175:Lung Neoplasms / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D017382:Reactive Oxygen Species
chemical_list: D017382:Reactive Oxygen Species; D000080242:8-Hydroxy-2'-Deoxyguanosine; D004247:DNA; D003849:Deoxyguanosine