title: Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies.
abstract: Alpha-synuclein forms the major component of Lewy bodies and Lewy neurites, the defining neuropathological characteristics of Parkinson's disease and dementia with Lewy bodies. Here we show that alpha-synuclein is also the major component of the filamentous inclusions of multiple system atrophy which comprises several neurodegenerative diseases with a shared filamentous pathology in nerve cells and glial cells. These findings provide an unexpected link between multiple system atrophy and Lewy body disorders and establish that alpha-synucleinopathies constitute a major class of human neurodegenerative disorder.
authors.affiliation: MRC Centre for Brain Repair and Department of Neurology, University of Cambridge, UK.
authors.forename: M G
authors.initials: MG
authors.lastname: Spillantini
authors.forename: R A
authors.initials: RA
authors.lastname: Crowther
authors.forename: R
authors.initials: R
authors.lastname: Jakes
authors.forename: N J
authors.initials: NJ
authors.lastname: Cairns
authors.forename: P L
authors.initials: PL
authors.lastname: Lantos
authors.forename: M
authors.initials: M
authors.lastname: Goedert
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002531:Cerebellum / Q000378:metabolism / Q000473:pathology; D003704:Dementia / Q000378:metabolism* / Q000473:pathology; D005625:Frontal Lobe / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D016631:Lewy Bodies / Q000378:metabolism* / Q000473:pathology; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000378:metabolism* / Q000473:pathology; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010300:Parkinson Disease / Q000378:metabolism* / Q000473:pathology; D011149:Pons / Q000378:metabolism / Q000473:pathology; D051843:Synucleins; D051844:alpha-Synuclein
chemical_list: D009419:Nerve Tissue Proteins; C497604:SNCA protein, human; D051843:Synucleins; D051844:alpha-Synuclein