Retrovirus-associated rheumatic syndromes.
The influence of environmental factors in the initiation of autoimmune rheumatic diseases is still under debate. Infections with viruses (e.g., retroviruses) or expression of gene products encoded by endogenous retroviruses are believed to contribute to both loss of tolerance for autoantigens and immunosuppression. In various rheumatic disorders the detection of retroviral antibodies provides evidence for retroviral gene expression and suggests a role in the etiopathogenesis. Molecular mimicry, defects in apoptosis, altered autoantigens, and alterations of monocyte or macrophage as well as dendritic cell functions may contribute to the molecular mechanisms causing the loss of tolerance. On the other hand, destruction of lymphocytes during lytic retrovirus infections as well as envelope gene-env derived immunosuppressive retroviral gene products may prevent chronic inflammatory diseases and tissue destruction. Furthermore, retrovirus encoded super-antigens with the potency to skew the T-cell repertoire may seriously modify the host's immune system.
Herrmann
M
M
Friedrich-Alexander University of Erlangen-Nuremberg, Department of Internal Medicine III, Germany.
Neidhart
M
M
Gay
S
S
Hagenhofer
M
M
Kalden
J R
JR
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D012192:Retroviridae Infections / Q000150:complications*; D012216:Rheumatic Diseases / Q000150:complications / Q000276:immunology / Q000821:virology*