[Cholestatic acute hepatitis induced by amoxycillin-clavulanic acid combination. Role of ursodeoxycholic acid in drug-induced cholestasis].
We report two cases of acute hepatotoxicity after treatment with amoxicillin-clavulanic. Viral hepatitis serology and autoantibodies were negative. Biliary tree obstruction and other etiologies were excluded. After discontinuation of the drug the evolution was favorable with clinical improvement and normalization of liver tests. Liver biopsy made in one patient showed cholestasic hepatitis with hepatocellular necrosis and other patient was treated with ursodeoxycholic. Also, we analyse potential utility of ursodeoxycholic acid administration in toxic cholestasis.
Barrio
J
J
Servicio de Aparato Digestivo, Hospital Ntra. Sra. de Aránzazi Universidad del País Vasco, San Sebastián.
Castiella
A
A
Lobo
C
C
Indart
A
A
López
P
P
García-Bengoechea
M
M
Cosme
A
A
Arenas
J I
JI
D000368:Aged; D000658:Amoxicillin / Q000009:adverse effects* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000494:pharmacology; D056486:Chemical and Drug Induced Liver Injury / Q000150:complications / Q000188:drug therapy / Q000209:etiology*; D002756:Cholagogues and Choleretics / Q000627:therapeutic use*; D002779:Cholestasis / Q000139:chemically induced* / Q000188:drug therapy; D019818:Clavulanic Acid / Q000009:adverse effects* / Q000494:pharmacology; D006801:Humans; D008297:Male; D010406:Penicillins / Q000009:adverse effects / Q000494:pharmacology; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D002756:Cholagogues and Choleretics; D010406:Penicillins; D019818:Clavulanic Acid; D014580:Ursodeoxycholic Acid; D000658:Amoxicillin