Principles of the photodynamic therapy and its impact on the immune system.
Photodynamic therapy (PDT) is an encouraging procedure for treatment and diagnosis of a wide variety of malignant processes. There are three main mechanisms by which tumors are destroyed during PDT: direct cell destruction, damage to the vascular stroma and immune elimination. PDT of high intensity, targeted to a large number of cells results in immunosuppression. Low dose/energy or localized PDT stimulates the immune response against the tumor. The review reports recently performed animal experimental studies as well as the first human clinical studies.
Vanciková
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First Department of Pediatrics, 2nd Medical School, Charles University, Prague, Motol, Czech Republic.
D000818:Animals; D006801:Humans; D007111:Immunity, Cellular; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology; D010778:Photochemotherapy