title: Ostial renal artery stent placement for atherosclerotic renal artery stenosis in patients with coronary artery disease.
abstract: To test the utility of endoprosthetic treatment for ostial renal artery stenosis, and to examine blood pressure and its treatment, serum creatinine, and restenosis rate, 44 ostial renal stent placements were performed in 30 patients with concomitant coronary artery disease, arterial hypertension, and the indication for angiotensin converting enzyme (ACE) therapy. There was a marked decrease in systolic and diastolic blood pressure (163+/-30 to 145+/-17 and 93+/-18 to 83+/-10 mm Hg; P < 0.008) with a decrease in number of medication (3.2+/-0.9 to 2.8+/-1.0; P = 0.005). In 5 out of 8 patients not receiving an ACE inhibitor, this drug could be added. Serum creatinine changed from 1.46+/-0.7 mg/dl to 1.39+/-0.58 mg/dl (P = ns). Three patients showed restenosis (12.5%). Ostial stenting lowers blood pressure, decreases antihypertensive drugs and increases medication flexibility.
authors.affiliation: Franz Volhard Clinic, Max Delbrück Center for Molecular Medicine, Virchow Klinikum, Humboldt University of Berlin, Germany. gross@FVK-berlin.de
authors.forename: C M
authors.initials: CM
authors.lastname: Gross
authors.forename: J
authors.initials: J
authors.lastname: Krämer
authors.forename: J
authors.initials: J
authors.lastname: Waigand
authors.forename: F
authors.initials: F
authors.lastname: Uhlich
authors.forename: H
authors.initials: H
authors.lastname: Olthoff
authors.forename: F C
authors.initials: FC
authors.lastname: Luft
authors.forename: R
authors.initials: R
authors.lastname: Dietz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000792:Angiography; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D001161:Arteriosclerosis / Q000175:diagnosis / Q000628:therapy*; D003131:Combined Modality Therapy; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000628:therapy*; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D006978:Hypertension, Renovascular / Q000175:diagnosis / Q000628:therapy; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012078:Renal Artery Obstruction / Q000175:diagnosis / Q000628:therapy*; D015607:Stents; D016896:Treatment Outcome
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D003404:Creatinine