Advanced paternal age and de-novo complex chromosomal rearrangement in offspring.
We report one case of a de-novo complex chromosomal rearrangement (CCR), t(1;5;13)ins(14;13), in an abnormal 19-month-old boy. Clinical features associated were a mild facial dysmorphy and a psychomotor retardation. Parental ages were, respectively, 29 years for the mother and 60 years for the father. We point out the usefulness of fluorescence in-situ hybridization in elucidating CCRs, and discuss the possible correlation between the existence of a chromosomal aberration and advanced paternal age.
Benzacken
B
B
Laboratoire d'Histologie, Embryologie, Cytogénétique et Biologie de la Reproduction, Hôpital Jean Verdier, Bondy, France.
Siffroi
J P
JP
Straub
B
B
Le Bourhis
C
C
Sauvion
S
S
Gaudelus
J
J
Dadoune
J P
JP
Wolf
J P
JP
D000328:Adult; D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1; D002882:Chromosomes, Human, Pair 13; D002883:Chromosomes, Human, Pair 14; D002895:Chromosomes, Human, Pair 5; D005147:Facial Bones / Q000002:abnormalities*; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D010331:Paternal Age; D011596:Psychomotor Disorders / Q000235:genetics*