A historical perspective and cellular regulation of megakaryocytopoiesis.
With the recent accumulation of information about megakaryocyte biochemistry and function, our understanding of the regulatory system controlling megakaryocytopoiesis is becoming more clear. The cloning and the expression of thrombopoietin, the regulator of megakaryocytopoiesis, has been a major breakthrough. This review will discuss megakaryocyte ontogeny, cell-cell interactions between megakaryocytes and the other stromal cells and the signal transduction in megakaryocytes.
Baatout
S
S
Laboratory of Experimental Hematology and Oncology, UCL, Brussels, Belgium. sbaatout@sckcen.be
D000818:Animals; D002450:Cell Communication; D006412:Hematopoietic Stem Cells / Q000502:physiology; D006801:Humans; D019891:Leukopoiesis; D008533:Megakaryocytes / Q000502:physiology*; D015398:Signal Transduction; D013926:Thrombopoietin / Q000502:physiology
D013926:Thrombopoietin