Somitogenesis: segmenting a vertebrate.
The partitioning of the vertebrate body into a repetitive series of segments, or somites, requires the spatially and temporally co-ordinated behaviour of mesodermal cells. To date, it remains unknown how applicable our knowledge of the genetic mechanisms governing Drosophila segmentation will be to that of vertebrates, though recent results indicate some degree of conservation. Genetic studies in the mouse point to a major role for the Notch-Delta signalling pathway in somite formation. Furthermore, a molecular clock may be 'ticking' in the presomitic mesoderm.
McGrew
M J
MJ
Laboratoire de Génétique et de Physiologie du Développement (LGPD). CNRS-INSERM-Université de la méditerranée-AP de Marseille, France. mcgrew@ibdm.univ-mrs.fr
Pourquié
O
O
D000818:Animals; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D051880:Receptors, Notch; D015398:Signal Transduction; D019170:Somites; D014714:Vertebrates / Q000196:embryology*
D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D051880:Receptors, Notch; C064045:delta protein