title: Lens transmission by fluorophotometry after brachytherapy and thermotherapy of choroidal melanoma.
abstract: We studied the effect of transpupillary thermotherapy (TTT) by a diode laser at 810 nm combined with episcleral ruthenium-106 plaque treatment (106Ru) on lens transparency in patients with choroidal melanoma. Lens transmission of blue-green light was measured by fluorophotometry in 17 patients treated with 106Ru treatment and TTT (measured 0.36 years after treatment), 12 patients treated with 106Ru alone (measured 19 years after treatment) and 25 age-matched healthy controls. Differences in lens transmission were not significant between treated and untreated fellow eyes (p > 0.15) nor between patient and control eyes (p > 0.25). TTT of choroidal melanoma combined with 106Ru plaque irradiation did not have a significant effect on the lens transparency up to 6 years after treatment.
authors.affiliation: Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: A C
authors.initials: AC
authors.lastname: Weenink
authors.forename: J A
authors.initials: JA
authors.lastname: van Best
authors.forename: J A
authors.initials: JA
authors.lastname: Oosterhuis
authors.forename: J E
authors.initials: JE
authors.lastname: Keunen
mesh_terms: D000368:Aged; D001918:Brachytherapy; D002830:Choroid Neoplasms / Q000503:physiopathology* / Q000628:therapy*; D003131:Combined Modality Therapy; D015590:Fluorophotometry; D006801:Humans; D006979:Hyperthermia, Induced; D007908:Lens, Crystalline / Q000503:physiopathology*; D008545:Melanoma / Q000503:physiopathology* / Q000628:therapy*; D008875:Middle Aged; D012016:Reference Values; D012429:Ruthenium Radioisotopes / Q000627:therapeutic use
chemical_list: D012429:Ruthenium Radioisotopes