Antisense therapeutics.
The field of antisense therapeutics has attracted great interest during the past decade. A large body of literature has recently appeared in which the antisense mechanism is claimed to be involved and a number of human clinical trials are underway. Questions regarding the specificity of action and side effects of antisense phosphorothioate oligonucleotides have arisen simultaneously.
Agrawal
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S
Hybridon Inc, Cambridge, MA 02139, USA. sagrawal@hybridon.com
Zhao
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Q
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D015195:Drug Design; D004359:Drug Therapy, Combination; D006801:Humans; D016376:Oligonucleotides, Antisense / Q000493:pharmacokinetics / Q000627:therapeutic use* / Q000633:toxicity; D013873:Thionucleotides / Q000493:pharmacokinetics / Q000627:therapeutic use* / Q000633:toxicity; D014018:Tissue Distribution
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D016376:Oligonucleotides, Antisense; D013873:Thionucleotides