Multiple hormone resistance in short children born with intrauterine growth retardation?
Intrauterine growth retardation (IUGR) is encountered in 2.5% (-2 SD) of newborns. Lack of postnatal catch-up growth is found in 8-20%. If GH secretion is increased early postnatally in IUGR, then some persistently short IUGR children may present with GH insufficiency. However, the mechanism of postnatal catch-up growth is heterogenous. The response to GH treatment with regard to plasma IGF-1, GH dose and growth velocity was analyzed in persistently short idiopathic IUGR children and compared to GH-deficient (GHD) and familial short stature (FSS) children of similar age and degree of short stature. IUGR children require both a greater basal and GH-induced plasma IGF-1 in order to achieve a growth velocity of similar magnitude to that of FSS and GHD children. These data suggest a different sensitivity to GH in IUGR compared to FSS or GHD children, sustaining the hypothesis that these idiopathic IUGR children may be partially IGF-1 resistant. The recent report of partial insulin resistance in IUGR subjects raises the possibility of an IGF-1 receptor- or post-receptor-mediated defect.
Chatelain
P G
PG
Department of Pediatrics, Université Claude-Bernard and INSERM U 418, Hôpital Debrousse, Lyon.
Nicolino
M
M
Claris
O
O
Salle
B
B
Chaussain
J
J
D018432:Drug Resistance, Multiple; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology* / Q000378:metabolism* / Q000503:physiopathology; D006728:Hormones / Q000502:physiology*; D019382:Human Growth Hormone / Q000172:deficiency / Q000502:physiology; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000502:physiology*; D011247:Pregnancy
D006728:Hormones; D019382:Human Growth Hormone