Comparison of somatomedin-C (SMC/IGF-I), human placental lactogen and Doppler velocimetry between appropriate and small-for-gestational-age pregnancies.
Thirty-two pregnant women with small-for-gestational-age (SGA) fetuses and 45 pregnant women with appropriate-for-gestional-age (AGA) fetuses (controls) were recruited after the 32nd week of gestation. Blood samples were collected for estimation of somatomedin-C (SMC/IGF-I) and hPL in the maternal serum and in the umbilical cord serum. The systolic/diastolic (S/D) ratio of the umbilical artery was also recorded. The results showed somatomedin-C and hPL levels in the maternal serum and in the umbilical cord to be significantly decreased and the Doppler S/D ratio to be significantly increased in the SGA group. In this group, using the multivariable regression analysis, we found significant correlations between maternal hPL, somatomedin-C, Doppler S/D ratio and birth weight.
Stefanidis
K
K
Department of Obstetrics and Gynecology, Winthrop University Hospital, Mineola, New York, USA.
Solomou
E
E
Mouzakioti
E
E
Stefos
T
T
Farmakides
G
G
D001724:Birth Weight; D001783:Blood Flow Velocity; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D015999:Multivariate Analysis; D010865:Pilot Projects; D010928:Placental Lactogen / Q000097:blood*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third / Q000097:blood*; D012212:Rheology; D014469:Umbilical Arteries / Q000502:physiology*
D007334:Insulin-Like Growth Factor I; D010928:Placental Lactogen