title: Effect of rebamipide on H. pylori-associated gastric mucosal injury in Mongolian gerbils.
abstract: Helicobacter pylori colonized to gastric mucosa plays an important pathogenic role in gastric mucosal lesions. We previously reported that ethanol pretreatment promotes the extension of H. pylori-associated lesions. The present study was designed to examine the effect of rebamipide, a mucosal protective agent, on H. pylori-associated injury. Male Mongolian gerbils were orally inoculated with H. pylori; 30 min prior to inoculation, 40% ethanol was administered orally to these gerbils (Hp group). Controls were given 40% ethanol with culture medium (control group). Some gerbils in the Hp and control groups were fed rebamipide-containing diets, and the remaining gerbils received laboratory chow diets. H. pylori infection was evaluated by quantitative bacterial culture and histological examination. Although H. pylori was persistently detected and a remarkable mucosal leukocyte infiltration was observed in the Hp groups, the bacteria had disappeared naturally in 67% of the gerbils and mucosal damage was mitigated in the Hp + rebamipide group at four weeks after the inoculation. Collectively, rebamipide might play a role in inhibiting the level of H. pylori colonization and gastric lesion formation in Mongolian gerbils.
authors.affiliation: Department of Internal Medicine and Biochemistry, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: M
authors.initials: M
authors.lastname: Mori
authors.forename: A
authors.initials: A
authors.lastname: Kai
authors.forename: M
authors.initials: M
authors.lastname: Suzuki
authors.forename: M
authors.initials: M
authors.lastname: Suematsu
authors.forename: S
authors.initials: S
authors.lastname: Miura
authors.forename: H
authors.initials: H
authors.lastname: Ishii
mesh_terms: D000409:Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000382:microbiology / Q000473:pathology; D005849:Gerbillinae; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000473:pathology; D016480:Helicobacter pylori; D008297:Male; D015363:Quinolones / Q000494:pharmacology*; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology
chemical_list: D000897:Anti-Ulcer Agents; D015363:Quinolones; C052785:rebamipide; D000409:Alanine