title: Treatment and prognosis in a series of primary extranodal lymphomas of the ocular adnexa.
abstract: BACKGROUND
  The aim of this study was to assess clinicopathological characteristics and outcome in a series of primary ocular adnexal lymphomas (POALs).
  
  
  METHODS
  Nineteen patients with localised (stage IE) POAL were followed for a median of 96 months (24-156). The diagnosis was based on surgical biopsies followed by immunohistochemistry in 16 cases or fine-needle aspiration followed by immunocytophenotypic analysis in three cases. Twelve patients were treated with local radiotherapy (RT), five with chemotherapy (CT), and two refused further therapy after apparently radical tumour removal achieved by the diagnostic excisional biopsy.
  
  
  RESULTS
  The histological and immunological pattern was consistent with a diagnosis of MALT-type lymphoma (11 cases), follicular center non-Hodgkin's lymphoma (three cases). a large-cell variant of Burkitt's lymphoma (one case), and large-cell transformed MALT lymphoma (one case). Low-grade lymphoma was diagnosed in the three cases which underwent fine-needle aspiration biopsy. All of the patients achieved and maintained complete remission except for those treated with surgical excision alone (two MALT conjunctival lymphoma cases): one of these relapsed locally, the other experienced the systemic spread of a transformed diffuse large-cell lymphoma and died 72 months after diagnosis. The side effects consisted of two cases of RT-related cataract after 52 and 72 months.
  
  
  CONCLUSIONS
  Regardless of histology, prognosis was excellent when surgery plus RT was adopted, and CT seems to be a valid alternative to RT. Surgery alone may be sub-optimal.
authors.affiliation: Servizio di Ematologia, Università di Milano, Ospedale Maggiore, I.R.C.C.S., Italy.
authors.forename: L
authors.initials: L
authors.lastname: Baldini
authors.forename: M
authors.initials: M
authors.lastname: Blini
authors.forename: A
authors.initials: A
authors.lastname: Guffanti
authors.forename: V
authors.initials: V
authors.lastname: Fossati
authors.forename: M
authors.initials: M
authors.lastname: Colombi
authors.forename: M L
authors.initials: ML
authors.lastname: La Targia
authors.forename: F
authors.initials: F
authors.lastname: Bertoni
authors.forename: A
authors.initials: A
authors.lastname: Alietti
authors.forename: A
authors.initials: A
authors.lastname: Neri
authors.forename: G
authors.initials: G
authors.lastname: Bertoni
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005134:Eye Neoplasms / Q000401:mortality / Q000628:therapy*; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D008223:Lymphoma / Q000401:mortality / Q000628:therapy*; D018442:Lymphoma, B-Cell, Marginal Zone / Q000401:mortality / Q000628:therapy; D008224:Lymphoma, Follicular / Q000401:mortality / Q000628:therapy; D016403:Lymphoma, Large B-Cell, Diffuse / Q000401:mortality / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011879:Radiotherapy Dosage; D016019:Survival Analysis