Estrogen, androgen and antiestrogen responses in the accessory organs of male rats during different phases of life.
Recent studies have indicated that estrogen has a stimulatory influence on the male reproductive tract. Evidence includes the presence of measurable levels of estrogen in the circulation, retention of exogenous estrogen, and presence of estrogen receptors in the male accessory sex organs during prepubertal life. In the present study, estrogen antagonists (CDRI-85/287 and centchroman) have been used to examine this concept by antagonising estrogen action at critical stages in the life in rat. Centchroman or 85/287 administration to 14 day old rats for 7 days did not alter gonadal or accessory organ weight. In contrast, in 21 day old castrated rats, treatment with either compound from day 28-35 of life stimulated an increase in all organ weights. When administered to normal rats during the critical phase of transition, i.e. days 30-60 of life, both testis and accessory organs showed an increase in weight. In contrast castrated rats treated with estrogen alone or in combination with 85/287 from days 37-45 of life and sacrificed on day 46 did not show any change, but 85/287 per se markedly reduced the weight of accessory organs. In adult castrated rats, the potency of DHT as a promoter of growth was potentiated by estradiol. Compound 85/287 negated the estradiol-induced increase. Glycerylphosphorylcholine (GPC) and sialic acid levels showed about 100% increase, with both high and low doses of 85/287 (treated from 30-60 days of life), However, centchroman (CDRI-67/20) was less potent in this regard. The effect of estrogen antagonists in relation to epididymal physiology during different phases of life in the rat is discussed.
Dhar
J D
JD
Division of Endocrinology, Central Drug Research Institute, Lucknow, India.
Mishra
R
R
Setty
B S
BS
D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology; D002486:Centchroman / Q000494:pharmacology; D013196:Dihydrotestosterone / Q000494:pharmacology*; D004822:Epididymis / Q000187:drug effects; D004958:Estradiol / Q000819:agonists / Q000494:pharmacology*; D004965:Estrogen Antagonists / Q000494:pharmacology*; D005837:Genitalia, Male / Q000187:drug effects*; D005997:Glycerylphosphorylcholine / Q000032:analysis; D008297:Male; D019158:N-Acetylneuraminic Acid / Q000032:analysis; D009919:Orchiectomy; D009929:Organ Size / Q000187:drug effects; D010880:Piperidines / Q000494:pharmacology; D011467:Prostate / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012669:Seminal Vesicles / Q000187:drug effects; D012741:Sexual Maturation
D001578:Benzopyrans; D004965:Estrogen Antagonists; D010880:Piperidines; D013196:Dihydrotestosterone; C066624:CDRI 85-287; D002486:Centchroman; D004958:Estradiol; D005997:Glycerylphosphorylcholine; D019158:N-Acetylneuraminic Acid