[Comparative data on the use of a cryosupernatant and fresh-frozen plasma in the therapy of a protracted infectious-septic syndrome of disseminated intravascular coagulation].
OBJECTIVE
To compare therapeutic effectiveness of cryosupernatant plasma fraction (CSP) and fresh-frozen plasma (FFP) in long-term infectious-septic DIC syndrome arising in acute abscess and gangrene of the lung.


METHODS
106 and 131 patients with infectious-septic DIC syndrome were treated with CSP and FFP, respectively. The results of the treatment were compared clinically and hemotopogically.


RESULTS
Clinical response to both treatments was evident from positive changes in XIIa-dependent fibrinolysis, lowering of fibrinogen level and enhanced activity of antithrombin III. CSP treatment brought about a decrease in the number of thromboses, lethal cases, unfavorable outcomes.


CONCLUSIONS
The cryosupernatant can be used instead of fresh-frozen plasma in combined treatment of long-standing infectious-septic DIC syndrome.
Barkagan
Z S
ZS
Shoĭkhet
Ia N
IaN
Elykomov
V A
VA
Erin
E N
EN
Erin
D N
DN
D003131:Combined Modality Therapy; D015925:Cryopreservation; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000209:etiology / Q000628:therapy*; D016724:Empyema, Pleural / Q000097:blood / Q000209:etiology / Q000628:therapy; D005734:Gangrene; D006487:Hemostasis; D006801:Humans; D008168:Lung / Q000473:pathology; D008169:Lung Abscess / Q000097:blood / Q000150:complications / Q000628:therapy; D010949:Plasma; D010951:Plasma Exchange; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood / Q000209:etiology / Q000628:therapy*; D013997:Time Factors