[Histone deacetylase and retinoblastoma protein].
The balance between cellular proliferation and differentiation is strictly controlled in the cell and the deregulation of this balance can lead to tumour formation. The tumour suppressor protein Rb plays a key role in this balance essentially by repressing progression through the cell cycle and thereby it blocks the cell in G1 phase. Rb represses S phase genes through the recruitment of an enzyme which modifies DNA structure, the histone deacetylase HDAC1. The Rb/HDAC1 complex is a key element in the control of cell proliferation and differentiation. Moreover, this complex is likely to be a target for transforming viral proteins.
Magnaghi-Jaulin
L
L
Laboratoire Oncogenèse, Différenciation et Transduction du signal, CNRS UPR 9079, Villejuif.
Groisman
R
R
Naguibneva
I
I
Robin
P
P
Trouche
D
D
Harel-Bellan
A
A
D017500:Adenovirus E1A Proteins / Q000502:physiology; D002352:Carrier Proteins; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins; D002454:Cell Differentiation / Q000502:physiology*; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D056284:Histone Deacetylase 1; D006655:Histone Deacetylases / Q000502:physiology*; D006801:Humans; D009856:Oncogene Proteins, Viral / Q000502:physiology; D027383:Papillomaviridae; D010766:Phosphorylation; D016160:Retinoblastoma Protein / Q000378:metabolism / Q000502:physiology*; D056465:Retinoblastoma-Binding Protein 1; D016196:S Phase / Q000502:physiology; D050680:Transcription Factor DP1; D014157:Transcription Factors / Q000378:metabolism / Q000502:physiology*
D017500:Adenovirus E1A Proteins; D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D009856:Oncogene Proteins, Viral; D016160:Retinoblastoma Protein; D056465:Retinoblastoma-Binding Protein 1; D050680:Transcription Factor DP1; D014157:Transcription Factors; C110550:HDAC1 protein, human; D056284:Histone Deacetylase 1; D006655:Histone Deacetylases