title: Slipped capital femoral epiphysis. A report of 4 cases occurring in one family.
abstract: We describe slipped capital femoral epiphysis in 4 members of a black, obese family, who were all first-degree relatives. The aetiology of slipped capital femoral epiphysis is unknown, although it is thought to be multifactorial. Genetic predisposition and environmental factors have been associated with the condition. A familial incidence with at least two cases in the same family has been reported. In epidemiological studies, this incidence ranges from 3% to 35%. Our cases were investigated in an attempt to find a possible aetiological genetic factor. A genetic predisposition with an autosomal dominant pattern of transmission is suggested, although environmental variables must be considered as provocative factors.
authors.affiliation: Department of Orthopaedics, Hospital Curry Cabral, Lisbon, Portugal.
authors.forename: J F
authors.initials: JF
authors.lastname: Moreira
authors.forename: M C
authors.initials: MC
authors.lastname: Neves
authors.forename: G
authors.initials: G
authors.lastname: Lopes
authors.forename: A R
authors.initials: AR
authors.lastname: Gomes
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D004839:Epiphyses, Slipped / Q000000981:diagnostic imaging / Q000235:genetics*; D005260:Female; D005270:Femur Head; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D009765:Obesity / Q000097:blood / Q000150:complications; D010375:Pedigree; D010641:Phenotype; D011859:Radiography; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism
chemical_list: D007328:Insulin; D012738:Sex Hormone-Binding Globulin