title: Apolipoprotein E4, lipoprotein lipase C447 and angiotensin-I converting enzyme deletion alleles were not associated with increased wall thickness of carotid and femoral arteries in healthy subjects from the Stanislas cohort.
abstract: Studies have shown contrasting results concerning the relation between carotid intima-media thickness (IMT) and apolipoprotein E (apo E) and angiotensin-converting enzyme (ACE) polymorphisms. Subjects, 76 men and 74 women, between 33 and 50 years, without any history of cardiovascular disease and without any anti-hypertensive or lipid lowering medication were selected from the Stanislas cohort. The IMT of carotid and femoral arteries were investigated by B-mode ultrasonography. The common apo E, (C/G)447 lipoprotein lipase (LPL) and I/D ACE gene polymorphisms and serum ACE activity were determined. In the overall sample, male sex, age, systolic blood pressure, BMI, serum apo B level and tobacco consumption were positively correlated with carotid and femoral IMT. The common apo E polymorphism, the (C/G)LPL447 polymorphism and ACE activity were not related to carotid and femoral IMT variability in either men or women. Unexpectedly, the I allele of the ACE gene was related to higher femoral IMT than the D allele in non-smokers only. Similar results were observed after adjustment for the main covariates of IMT variability. In conclusion, amongst our young adult sample the candidate risk factors for cardiovascular disease, apo epsilon4, C447-LPL and D-ACE alleles and ACE activity were not associated with increased carotid and femoral IMT.
authors.affiliation: Centre de Médecine Préventive Vandoeuvre-lès-Nancy, France.
authors.forename: C
authors.initials: C
authors.lastname: Sass
authors.forename: F
authors.initials: F
authors.lastname: Zannad
authors.forename: B
authors.initials: B
authors.lastname: Herbeth
authors.forename: D
authors.initials: D
authors.lastname: Salah
authors.forename: O
authors.initials: O
authors.lastname: Chapet
authors.forename: G
authors.initials: G
authors.lastname: Siest
authors.forename: S
authors.initials: S
authors.lastname: Visvikis
mesh_terms: D000328:Adult; D000483:Alleles; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D002339:Carotid Arteries / Q000737:chemistry / Q000473:pathology*; D015331:Cohort Studies; D005260:Female; D005263:Femoral Artery / Q000737:chemistry / Q000473:pathology*; D017353:Gene Deletion; D005787:Gene Frequency; D006801:Humans; D008071:Lipoprotein Lipase / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D017539:Tunica Intima / Q000737:chemistry / Q000473:pathology
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D008071:Lipoprotein Lipase; D007703:Peptidyl-Dipeptidase A