Effect of estrogen and progesterone on newly synthesised and released human fallopian tube specific proteins.
Current study was carried out to identify the profile of newly synthesized and released proteins by human fallopian tube (hFT). Results indicated that hFT during menopause synthesised and released only 2-3 proteins as against several proteins ranging from molecular weight (MW) approximately 20 to approximately 130 kD during normal menstrual cycle. In vitro addition of estradiol-17 beta (E2) resulted in synthesis and release of a number of proteins including specific protein of MW 110-130 kD. Addition of progesterone (P) however, led to inhibition of protein synthesis and a combination of E2 and P negated the effect of the latter. An alteration in oviductal secretory protein-profile following addition of E2 in vitro were similar to that observed during normal menstrual cycle.
Shah
A S
AS
Institute for Research in Reproduction (ICMR), Bombay, India.
Kundale
S
S
Raghavan
V P
VP
Nandedkar
T D
TD
Hinduja
I
I
Parulekar
S V
SV
Natraj
U
U
D046508:Culture Techniques; D004967:Estrogens / Q000494:pharmacology*; D005187:Fallopian Tubes / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D006801:Humans; D008715:Methionine / Q000378:metabolism; D011374:Progesterone / Q000494:pharmacology*; D014176:Protein Biosynthesis; D011506:Proteins / Q000378:metabolism
D004967:Estrogens; D011506:Proteins; D011374:Progesterone; D008715:Methionine