[Aging of the crystalline lens and presbyopia].
The crystalline lens changes both optically and mechanically with age: it becomes less transparent and more difficult to deform. Using a new ultrasound technique, Continuous Ultrasonographic Biometry (CUB), we were able to demonstrate that presbyopia is caused by increased stiffness of the lens due to changes in lens fibre membranes and cytoskeleton. These results are important for further research on the ageing processes that lead to cataract and presbyopia, and the treatment of these conditions.
Beers
A P
AP
Polikliniek Oogheelkunde, Ziekenhuis St. Jansdal, Harderwijk.
van der Heijde
G L
GL
Dubbelman
M
M
D000293:Adolescent; D000328:Adult; D000375:Aging / Q000502:physiology*; D002386:Cataract / Q000209:etiology; D005260:Female; D006801:Humans; D007903:Lens Capsule, Crystalline / Q000503:physiopathology; D007908:Lens, Crystalline / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011305:Presbyopia / Q000209:etiology; D014463:Ultrasonography / Q000295:instrumentation