Cell cycle: oiling the gears of anaphase.
The anaphase-promoting complex (APC) or cyclosome directs the ubiquitination and destruction of proteins that control specific steps in mitosis. Recent studies show that APC activity requires WD40 domain proteins, and that one of these proteins is part of the checkpoint control that ensures accurate chromosome segregation.
Wolf
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Department of Pathology, Stanford University School of Medicine, Palo Alto, California 94305, USA.
Jackson
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D000705:Anaphase / Q000502:physiology; D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D017868:Cyclic AMP-Dependent Protein Kinases; D018844:Cyclin-Dependent Kinases / Q000378:metabolism; D005656:Fungal Proteins / Q000502:physiology; D008025:Ligases / Q000502:physiology; D008938:Mitosis; D008954:Models, Biological; D011506:Proteins / Q000378:metabolism; D043743:Ubiquitin-Protein Ligase Complexes; D044767:Ubiquitin-Protein Ligases; D014452:Ubiquitins / Q000378:metabolism
D005656:Fungal Proteins; D011506:Proteins; D014452:Ubiquitins; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome; D044767:Ubiquitin-Protein Ligases; D017868:Cyclic AMP-Dependent Protein Kinases; D018844:Cyclin-Dependent Kinases; D008025:Ligases