title: Vascular deprivation-induced necrosis of the femoral head of the rat. An experimental model of avascular osteonecrosis in the skeletally immature individual or Legg-Perthes disease.
abstract: The blood supply of rats' femoral heads was severed by cutting the ligamentum teres and stripping the periostium. Histologically, necrosis of the marrow was apparent on the 2nd postoperative day, necrosis of the bone on the 5th postoperative day and fibrous ingrowth on the 7th postoperative day. During the following 5 weeks, progressive resorption of the intertrabecular necrotic debris and necrotic bony trabeculae and subchondral bone plate and, concurrently, appositional and intramembranous new bone formation resulted in remodeling of the femoral heads. In 2 of 7 femoral heads, replacement of the necrotic bone by viable bone was complete at the 42-day postoperative interval. Also, the articular cartilage of the deformed and flattened femoral heads was undergoing degenerative changes. Reduplicating the pathogenically inferred clinical settings of blood supply deprivation, it is proposed that this model, in a small laboratory animal, satisfies the requirements sought for preclinical studies of treatment modalities of avascular osteonecrosis in man.
authors.affiliation: Department of Orthopaedic Surgery B, Rambam Medical Centre, Haifa, Israel.
authors.forename: D
authors.initials: D
authors.lastname: Norman
authors.forename: D
authors.initials: D
authors.lastname: Reis
authors.forename: C
authors.initials: C
authors.lastname: Zinman
authors.forename: I
authors.initials: I
authors.lastname: Misselevich
authors.forename: J H
authors.initials: JH
authors.lastname: Boss
mesh_terms: D000818:Animals; D016723:Bone Remodeling; D002358:Cartilage, Articular / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D005270:Femur Head / Q000098:blood supply*; D005271:Femur Head Necrosis / Q000209:etiology* / Q000473:pathology; D007873:Legg-Calve-Perthes Disease / Q000209:etiology / Q000473:pathology; D051381:Rats; D012039:Regional Blood Flow; D013997:Time Factors