Effect of terguride on insulin binding, insulinaemia, glucose tolerance and hyperlipaemia in lean SHR Koletsky rats.
Glucose tolerance, insulin binding to erythrocytes, insulinaemia, plasma total cholesterol, plasma triglycerides, weight of fat pads, food consumption and body weight changes were studied in genetically hypertensive lean Koletsky rats. Long-term treatment with dopaminergic agonist terguride (0.2 mg/kg/day) normalized glucose tolerance and increased the percentage of bound insulin to erythrocytes in both sexes. Terguride decreased insulinaemia, cholesterolaemia, fat pads and body weight only in female rats. Food consumption was not influenced by terguride over the injection period.
Golda
V
V
Institute of Experimental Neurosurgery, Hradec Králové, Czech Republic.
Hilgertová
J
J
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D018491:Dopamine Agonists / Q000494:pharmacology*; D004435:Eating / Q000187:drug effects; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D005951:Glucose Tolerance Test; D006949:Hyperlipidemias / Q000097:blood / Q000503:physiopathology*; D007328:Insulin / Q000097:blood*; D008090:Lisuride / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR
D018491:Dopamine Agonists; D007328:Insulin; C006208:dironyl; D008090:Lisuride