title: [Influence of auxiliary materials on the proportion of effective particle size of metered-dose suspension type aerosols].
abstract: The aim of the present study was to formulate suspension type inhalation aerosols by various types of auxiliary materials, and to select the formulation with the highest proportion of the effective particle size. The examined suspension type aerosol contained sodium cromoglycate as an active compound. For the stabilization of the suspension, the applied surface active ingredients were oleic acid and oleyl oleate, and dimethyl siloxane polymer was selected as hydrophobizing agent. Factorial design was used for the optimization of the experimental results. On the basis of our results, the correct types and amounts of auxiliary materials can be selected to obtain the therapeutically effective formulation.
authors.affiliation: EGIS Gyógyszergyár, Budapest.
authors.forename: L
authors.initials: L
authors.lastname: Fedina
authors.forename: R
authors.initials: R
authors.lastname: Zelkó
authors.forename: L
authors.initials: L
authors.lastname: Fedina
authors.forename: Z
authors.initials: Z
authors.lastname: Szabados
authors.forename: M
authors.initials: M
authors.lastname: Szántó
authors.forename: G
authors.initials: G
authors.lastname: Vakulya
mesh_terms: D000280:Administration, Inhalation; D000336:Aerosols; D002626:Chemistry, Pharmaceutical; D004205:Cromolyn Sodium / Q000008:administration & dosage* / Q000737:chemistry; D004129:Dimethylpolysiloxanes; D004355:Drug Stability; D019301:Oleic Acid; D012828:Silicones; D013501:Surface-Active Agents; D014906:Wetting Agents
chemical_list: D000336:Aerosols; D004129:Dimethylpolysiloxanes; D012828:Silicones; D013501:Surface-Active Agents; D014906:Wetting Agents; D019301:Oleic Acid; C013830:baysilon; D004205:Cromolyn Sodium