title: Motor neuron-derived retinoid signaling specifies the subtype identity of spinal motor neurons.
abstract: The diversification of neuronal cell types in the vertebrate central nervous system depends on inductive signals provided by local organizing cell groups of both neural and nonneural origin. The influence of signals provided by postmitotic neurons on the fate of neurons born at subsequent development stages, however, remains unclear. We provide evidence that a retinoid-mediated signal provided by one subset of early-born spinal motor neurons imposes a local variation in the number of motor neurons generated at different axial levels and also specifies the identity of a later-born subset of motor neurons. Thus, in the vertebrate central nervous system the distinct fates of late-born neurons may be acquired in response to signals provided by early-born neurons.
authors.affiliation: Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA.
authors.forename: S
authors.initials: S
authors.lastname: Sockanathan
authors.forename: T M
authors.initials: TM
authors.lastname: Jessell
mesh_terms: D000445:Aldehyde Oxidoreductases / Q000096:biosynthesis; D000818:Animals; D002454:Cell Differentiation; D002642:Chick Embryo; D004627:Embryonic Induction; D005552:Forelimb / Q000294:innervation; D015870:Gene Expression; D008959:Models, Neurological; D008969:Molecular Sequence Data; D009046:Motor Neurons / Q000166:cytology* / Q000378:metabolism; D018168:Receptors, Retinoic Acid; D050697:Retinal Dehydrogenase; D012176:Retinoids / Q000378:metabolism*; D015398:Signal Transduction; D013116:Spinal Cord / Q000196:embryology*; D013234:Stem Cells; D013900:Thoracic Nerves; D014018:Tissue Distribution
chemical_list: D018168:Receptors, Retinoic Acid; D012176:Retinoids; D000445:Aldehyde Oxidoreductases; D050697:Retinal Dehydrogenase