Self-sustaining status epilepticus after brief electrical stimulation of the perforant path.
We examined the duration of intermittent perforant path stimulation (PPS) needed to induce self-sustaining status epilepticus (SSSE) in rats. Seven-minute PPS did not induce SSSE. Some rats receiving 15 min and all animals after 30 min PPS developed SSSE that continued for hours. The animals killed 3 days after SSSE showed extensive neuronal damage. Those which were allowed to survive for 6 weeks after SSSE displayed spontaneous seizures.
Mazarati
A M
AM
Veteran Administration Medical Center, Neurology Service, UCLA School of Medicine, Sepulveda, USA. mazarati@ucla.edu
Wasterlain
C G
CG
Sankar
R
R
Shin
D
D
D000818:Animals; D001921:Brain / Q000473:pathology / Q000502:physiology; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D004569:Electroencephalography; D008297:Male; D009474:Neurons / Q000473:pathology / Q000502:physiology; D019580:Perforant Pathway / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000503:physiopathology; D013226:Status Epilepticus / Q000503:physiopathology*; D013997:Time Factors; D014851:Wakefulness