Suppression of heat-induced p53 accumulation and activation by CDDP or x-rays in human glioblastoma cells.
We showed that the prominent suppressions of heat-induced accumulation and activation of p53 by CDDP or X-rays were observed in A-172 cells, but not in T98G cells. In addition, the interactive hyperthermic enhancement of CDDP or X-ray cytotoxicity was observed in A-172 cells, but not in T98G cells. Our findings indicate that suppressions of heat-induced accumulation and activation of p53 by CDDP or X-rays contribute positively to an interactive hyperthermic enhancement of CDDP- or X-ray cytotoxicity.
Matsumoto
H
H
Department of Experimental Radiology and Health Physics, Fukui Medical University, Matsuoka, Fukui 910-1193, Japan.
Hayashi
S
S
Shioura
H
H
Ohtsubo
T
T
Nishida
T
T
Kitai
R
R
Ohnishi
T
T
Kano
E
E
D000970:Antineoplastic Agents / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002945:Cisplatin / Q000494:pharmacology*; D005909:Glioblastoma / Q000378:metabolism* / Q000473:pathology; D006358:Hot Temperature; D006801:Humans; D014407:Tumor Cells, Cultured / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects; D016159:Tumor Suppressor Protein p53 / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects*; D014965:X-Rays
D000970:Antineoplastic Agents; D016159:Tumor Suppressor Protein p53; D002945:Cisplatin