Cbfa1 in bone development.
A factor fundamental to bone formation has been identified. Gene targeting shows that core-binding factor alpha 1 (Cbfa1) plays an essential role in bone formation and osteoblast differentiation. Thus, it is now possible to begin examining the molecular mechanism of bone formation--especially osteoblast differentiation.
Komori
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Department of Medicine III, Osaka University Medical School, Japan. Science and Technology Corporation, Japan. komorit@imed3.med.osaka-u.ac.jp
Kishimoto
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D000818:Animals; D001846:Bone Development; D002454:Cell Differentiation; D002973:Cleidocranial Dysplasia / Q000235:genetics; D050659:Core Binding Factor Alpha 1 Subunit; D050660:Core Binding Factors; D015870:Gene Expression; D006801:Humans; D051379:Mice; D009154:Mutation; D009363:Neoplasm Proteins; D010006:Osteoblasts / Q000166:cytology; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*
D050659:Core Binding Factor Alpha 1 Subunit; D050660:Core Binding Factors; D009363:Neoplasm Proteins; D014157:Transcription Factors