title: Decreased exhaled nitric oxide may be a marker of cardiopulmonary bypass-induced injury.
abstract: BACKGROUND
  Nitric oxide is an endothelium-derived vasodilator. Cardiopulmonary bypass may induce transient pulmonary endothelial dysfunction with decreased nitric oxide release that contributes to postoperative pulmonary hypertension and lung injury. Exhaled nitric oxide levels may reflect, in part, endogenous production from the pulmonary vascular endothelium.
  
  
  METHODS
  We measured exhaled nitric oxide levels before and 30 minutes after cardiopulmonary bypass in 30 children with acyanotic congenital heart disease and left-to-right intracardiac shunts undergoing repair.
  
  
  RESULTS
  Exhaled nitric oxide levels decreased by 27.6%+/-5.6% from 7+/-0.8 to 4.4+/-0.5 ppb (p < 0.05) 30 minutes after cardiopulmonary bypass despite a reduction in hemoglobin concentration.
  
  
  CONCLUSIONS
  The decrease in exhaled nitric oxide levels suggests reduced nitric oxide synthesis as a result of pulmonary vascular endothelial or lung epithelial injury. This may explain the efficacy of inhaled nitric oxide in the treatment of postoperative pulmonary hypertension. Furthermore, strategies aimed at minimizing endothelial dysfunction and augmenting nitric oxide production during cardiopulmonary bypass may decrease the incidence of postoperative pulmonary hypertension. Exhaled nitric oxide levels may be useful to monitor both cardiopulmonary bypass-induced endothelial injury and the effect of strategies aimed at minimizing such injury.
authors.affiliation: Department of Anesthesia, The Hospital for Sick Children, University of Toronto, Ont, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Beghetti
authors.forename: P E
authors.initials: PE
authors.lastname: Silkoff
authors.forename: M
authors.initials: M
authors.lastname: Caramori
authors.forename: H M
authors.initials: HM
authors.lastname: Holtby
authors.forename: A S
authors.initials: AS
authors.lastname: Slutsky
authors.forename: I
authors.initials: I
authors.lastname: Adatia
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D004730:Endothelium, Vascular / Q000378:metabolism; D005260:Female; D006330:Heart Defects, Congenital / Q000601:surgery; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009569:Nitric Oxide / Q000032:analysis* / Q000096:biosynthesis; D012119:Respiration; D013997:Time Factors
chemical_list: D015415:Biomarkers; D009569:Nitric Oxide