Development of step-specific PET tracers for studying fatty acid beta-oxidation: biodistribution of [1-(11)C] octanoate analogs in rats and a cat.
To evaluate the potential of [1-(11)C]-3-(R,S)-methyloctanoate (BMOA), [1-(11)C]-2-octynoate, and [1-(11)C]-2-decynoate as PET tracers for studying particular steps in fatty acid beta-oxidation, we examined the pharmacokinetics of these compounds in rats and a cat. In rats given these compounds, high levels of radioactivity accumulated in the heart, liver, and kidneys, suggesting their potential as tracers for studying beta-oxidation in these tissues. These organs were clearly visible with PET in a cat given BMOA, indicating the utility of BMOA for imaging these organs.
Kawashima
H
H
Institute for Biofunctional Research, Suita-City, Osaka, Japan.
Kuge
Y
Y
Yajima
K
K
Miyake
Y
Y
Hashimoto
N
N
D000818:Animals; D002210:Caprylates / Q000493:pharmacokinetics*; D002250:Carbon Radioisotopes; D002415:Cats; D005227:Fatty Acids / Q000378:metabolism*; D008297:Male; D010084:Oxidation-Reduction; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed
D002210:Caprylates; D002250:Carbon Radioisotopes; D005227:Fatty Acids; D019275:Radiopharmaceuticals; C031492:octanoic acid