title: Albendazole therapy in children with focal seizures and single small enhancing computerized tomographic lesions: a randomized, placebo-controlled, double blind trial.
abstract: BACKGROUND
  Single small enhancing computerized tomographic (CT) lesions (SSECTLs) are common in children with focal seizures. These are considered to represent solitary cysticercus granulomas. Controversy exists regarding their treatment.
  
  
  OBJECTIVE
  To evaluate the efficacy of albendazole in cases of focal seizures with SSECTLs.
  
  
  METHODS
  Randomized, placebo-controlled, double blind trial.
  
  
  METHODS
  Pediatric service of Nehru Hospital, PGIMER, an urban tertiary care teaching hospital.
  
  
  METHODS
  63 children between 2 and 12 years of age with focal seizures for <3 months and SSECTLs.
  
  
  METHODS
  All children were randomly assigned to receive either albendazole (15 mg/kg/ day) or placebo for 28 days. CT scan was done at 1 and 3 months after beginning treatment. Codes opened after 6 months of inclusion in the study showed that 31 had received albendazole and 32 had received placebo. All children were followed up for at least 15 months.
  
  
  RESULTS
  Disappearance of lesions on CT scan was noted in 41% of albendazole vs. 16.2% of placebo patients after 1 month of follow-up (P < 0.05) and 64.5% of albendazole- vs. 37.5% of placebo-treated patients after 3 months of follow-up (P < 0.05). During the first 4 weeks of therapy seizure recurrence was seen in 9.7% of albendazole vs. 3.2% of placebo-treated children (odds ratio, 3.32; 95% confidence interval, 0.33 to 33.8). After 4 weeks seizure recurrence was seen in 31.3% of placebo-treated children vs. 12.9% of albendazole-treated children (odds ratio, 3.07; 95% confidence interval, 1.18 to 11.15).
  
  
  CONCLUSIONS
  Albendazole therapy results in significantly faster and increased resolution of solitary cysticercus lesions (SSECTLs) and appears to reduce the risk of late seizure recurrences.
authors.affiliation: Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: A K
authors.initials: AK
authors.lastname: Baranwal
authors.forename: P D
authors.initials: PD
authors.lastname: Singhi
authors.forename: N
authors.initials: N
authors.lastname: Khandelwal
authors.forename: S C
authors.initials: SC
authors.lastname: Singhi
mesh_terms: D000293:Adolescent; D015766:Albendazole / Q000627:therapeutic use*; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D001921:Brain / Q000000981:diagnostic imaging; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D020019:Neurocysticercosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy*; D012008:Recurrence; D012640:Seizures / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed
chemical_list: D000871:Anthelmintics; D015766:Albendazole