Notch signaling: direct or what?
Notch signaling has been implicated in a wide variety of processes from cell-fate decisions, tissue patterning and morphogenesis to human diseases and cancer. A model for Notch directly regulating gene expression has been proposed and at least two signaling pathways have been identified; however, the molecular mechanism(s) by which Notch signaling produces so many outcomes remains unclear.
Weinmaster
G
G
Department of Biological Chemistry, UCLA School of Medicine 90095-1737, USA. gweinmaster@mednet.ucla.edu
D000818:Animals; D030161:Avian Proteins; D010450:Endopeptidases / Q000378:metabolism; D051858:Forkhead Transcription Factors; D006801:Humans; D008024:Ligands; D008565:Membrane Proteins / Q000378:metabolism*; D015513:Oncogene Proteins; D011518:Proto-Oncogene Proteins; D051880:Receptors, Notch; D015398:Signal Transduction; D014764:Viral Proteins
D030161:Avian Proteins; D051858:Forkhead Transcription Factors; D008024:Ligands; D008565:Membrane Proteins; D015513:Oncogene Proteins; D011518:Proto-Oncogene Proteins; D051880:Receptors, Notch; D014764:Viral Proteins; C490425:v-qin protein, Avian sarcoma virus 31; D010450:Endopeptidases