title: Mechanisms of renal repair and survival following acute injury.
abstract: The reaction of the renal epithelium to injury is heterogenous. Some cells die, others survive apparently intact, while others commit to repair. The determinants of these responses appear to depend on signal transduction pathways and molecular responses that is segment specific and interactive. The kidney, as do cells in culture exposed to various noxious stimuli, react in a typical manner referred to as the stress response. The response is comprised of kinases and their molecular targets as well as cell cycle-specific factors that determine whether a cell survives the injury or not. We propose that this response can be modified by survival factors which upregulate those aspects of the response that are cytoprotective and which downregulate those that are cytoreductive. Preliminary data will be presented to demonstrate the feasibility of this approach.
authors.affiliation: University of Texas Medical Branch at Galveston, Department of Internal Medicine, 77555-0562, USA.
authors.forename: R
authors.initials: R
authors.lastname: Safirstein
authors.forename: J
authors.initials: J
authors.lastname: DiMari
authors.forename: J
authors.initials: J
authors.lastname: Megyesi
authors.forename: P
authors.initials: P
authors.lastname: Price
mesh_terms: D058186:Acute Kidney Injury / Q000503:physiopathology*; D000818:Animals; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000502:physiology; D002453:Cell Cycle; D002470:Cell Survival; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D015398:Signal Transduction
chemical_list: D006133:Growth Substances; D017871:Calcium-Calmodulin-Dependent Protein Kinases