New types of liposidomycins that inhibit bacterial peptidoglycan synthesis and are produced by Streptomyces. I. Producing organism and medium components.
Liposidomycins are atypical lipid-bearing nucleoside antibiotics that inhibit bacterial peptidoglycan synthesis. A producing strain was identified as a Streptomyces sp. from its cultural characteristics and physiological properties. It produced new types of liposidomycins that lacked sulfate and/or 3-methylglutaric acid moieties present in known liposidomycins by changing medium components. Sucrose and malt extract were particularly suitable sources for specific production of the new types of liposidomycins.
Kimura
K
K
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd., Tochigi, Japan.
Kagami
S
S
Ikeda
Y
Y
Takahashi
H
H
Yoshihama
M
M
Kusakabe
H
H
Osada
H
H
Isono
K
K
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D003470:Culture Media; D009168:Mycobacterium phlei / Q000187:drug effects; D010457:Peptidoglycan / Q000096:biosynthesis*; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D003470:Culture Media; D010457:Peptidoglycan; C047544:liposidomycins