Medullary thyroid carcinoma: genetic advances, treatment recommendations, and the approach to the patient with persistent hypercalcitoninemia.
Medullary thyroid cancer is a tumor of the thyroid C cells that occurs in sporadic and hereditary clinical settings. Genetic testing of at-risk individuals is available and has been applied to patient management. Plasma calcitonin levels are a sensitive marker for the presence of disease. Surgery offers the best hope for cure and also is an effective modality for managing metastatic and recurrent disease.
Chi
D D
DD
Division of General Surgery, Department of Surgery, Washington University School of Medicine, Saint Louis, Missouri, USA.
Moley
J F
JF
D014408:Biomarkers, Tumor / Q000097:blood; D002116:Calcitonin / Q000097:blood*; D018276:Carcinoma, Medullary / Q000097:blood / Q000235:genetics* / Q000473:pathology / Q000556:secondary / Q000601:surgery; D005500:Follow-Up Studies; D005820:Genetic Testing; D006579:Heterozygote; D006801:Humans; D018813:Multiple Endocrine Neoplasia Type 2a / Q000097:blood / Q000235:genetics / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D012307:Risk Factors; D013961:Thyroid Gland / Q000473:pathology; D013964:Thyroid Neoplasms / Q000097:blood / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D013965:Thyroidectomy
D014408:Biomarkers, Tumor; D002116:Calcitonin