Use of swine model in transplantation of vascularized skeletal tissue allografts.
Permanent tolerance to vascularized skeletal tissue allografts can be induced in miniature swine with minor antigen differences using a 12-day course of CsA. Demonstration of skeletal tissue allograft survival in a large animal model without long-term immunosuppression represents an important step toward transplantation of skeletal tissue allografts in humans.
Lee
W P
WP
Plastic Surgery Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA.
Rubin
J P
JP
Cober
S
S
Ierino
F
F
Randolph
M A
MA
Sachs
D H
DH
D000714:Anastomosis, Surgical; D000818:Animals; D016025:Bone Transplantation / Q000276:immunology / Q000502:physiology; D016572:Cyclosporine / Q000627:therapeutic use*; D005263:Femoral Artery / Q000601:surgery / Q000637:transplantation; D005268:Femoral Vein / Q000601:surgery / Q000637:transplantation; D006085:Graft Survival; D006614:Hindlimb / Q000637:transplantation*; D006650:Histocompatibility Testing; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D018482:Muscle, Skeletal / Q000637:transplantation; D016038:Skin Transplantation / Q000276:immunology / Q000502:physiology*; D013552:Swine; D013556:Swine, Miniature; D014184:Transplantation, Homologous / Q000276:immunology / Q000379:methods* / Q000502:physiology
D016572:Cyclosporine