Studies on blood compatibility of terpolymers composed of methyl methacrylate, methoxypolyethyleneglycol methacrylate, and dimethylsiloxane methacrylate.
Terpolymers composed of methyl methacrylate (MMA), polydimethylsiloxane methacrylate (PDMSMA), and methoxypolyethyleneglycol methacrylate (MPEGMA), having different compositions were synthesized. Platelets were not adsorbed onto terpolymer surfaces composed of 50 wt% MMA, 25 wt% PDMSMA and 25 wt% MPEGMA, while on terpolymers with the other compositions, platelet adsorption and fibrin clot were observed. It was shown that PDMS segment was predominant on these terpolymer surfaces via XPS. Receding contact angles of terpolymers, on which no platelet was observed, showed intermediate values between PDMS- and MPEG-rich surfaces. It was suggested that these terpolymers had blood compatibility.
Okamoto
H
H
Faculty of Engineering, Department of Applies Chemistry, Gifu University, Japan.
Osawa
H
H
Nakashima
S
S
Takahashi
S
S
Kasemura
T
T
Nozawa
Y
Y
D000328:Adult; D001672:Biocompatible Materials / Q000737:chemistry*; D001807:Blood Vessel Prosthesis / Q000009:adverse effects; D002152:Calorimetry, Differential Scanning; D002850:Chromatography, Gel; D004129:Dimethylpolysiloxanes / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008689:Methacrylates / Q000737:chemistry*; D020366:Methylmethacrylate / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D010973:Platelet Adhesiveness / Q000502:physiology; D011102:Polyhydroxyethyl Methacrylate / Q000031:analogs & derivatives* / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D013499:Surface Properties; D013927:Thrombosis / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control
D001672:Biocompatible Materials; D004129:Dimethylpolysiloxanes; D008689:Methacrylates; D011108:Polymers; C020689:methoxypolyethylene glycol 400 methacrylate; C115833:poly(dimethylsiloxane methacrylate); D020366:Methylmethacrylate; D011102:Polyhydroxyethyl Methacrylate