Pharmacological actions of Abies pindrow Royle leaf.
Petroleum ether (PE), benzene (BE), chloroform (CE), acetone (AE) and ethanolic (EE) extracts (50-200 or 200 mg/kg, i.p. or 200 mg/kg, p.o.) of dried Abies pindrow leaves, given 30-45 min before showed significant anti-inflammatory (both against acute and sub-acute models), analgesic, barbiturate hypnosis potentiation and anti-ulcerogenic acitivities in rats. All the extracts except EE decreased swim stress immobility in mice indicating some degree of anti-depressant activity. Only PE exhibited hypotension in dogs blocked by atropine. Chemically, extracts showed the presence of glycosides, steroids, terpenoids and flavonoids. They had no anti-bacterial effect. However, toxicity studies indicated that the extracts had an extended safety index. The investigations are consonant with some of the uses of this plant in Ayurveda.
Singh
R K
RK
Department of Pharmacology, Banaras Hindu University, Varanasi, India.
Nath
G
G
Goel
R K
RK
Bhattacharya
S K
SK
D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D000897:Anti-Ulcer Agents / Q000494:pharmacology; D002317:Cardiovascular Agents / Q000494:pharmacology; D004285:Dogs; D005260:Female; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats
D000700:Analgesics; D000890:Anti-Infective Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D002317:Cardiovascular Agents; D010936:Plant Extracts