The chemoprotective effect of coenzyme Q on lipids in the paint and lacquer industry workers.
The influence of coenzyme Q on the lipid parameters in the paint and lacquer industry workers is presented. The examinations were carried out in the group of 24 workers employed at the paint and lacquer production, who received coenzyme Q10 as a chemoprotective agent. Serum concentration of basic lipid parameters: total cholesterol (TC), high density lipoproteins (HDL), low density lipoproteins (LDL), triglycerides (TG); lipid peroxidation products: malonyldialdehyde (MDA) together with 4-hydroxynonenal (4-HNE) and two antioxidant enzymes: superoxide dismutase (SOD) and glutathione peroxidase (GPx) were examined. The above parameters were measured in workers exposed to organic solvents and then after 4 weeks of coenzyme Q treatment. In order to explain, whether the occupational exposure is responsible for the changed level of some parameters, the reference group, not employed in the paint and lacquer industry, was used. The results indicated that the preliminary blood serum concentration of MDA + 4-HNE in workers exposed to organic solvents was significantly elevated in comparison to the control group. Statistically significant decrease in MDA + 4HNE concentration was observed after coenzyme Q treatment what lead to the conclusion that coenzyme Q could be considered as a protective agent against lipid peroxidation in occupational exposure. The changes in other parameters were statistically insignificant.
Długosz
A
A
Department of Toxicology Wrocław University of Medicine, Poland.
Sawicka
E
E
D000328:Adult; D002617:Chemical Industry; D004305:Dose-Response Relationship, Drug; D004784:Environmental Monitoring; D005260:Female; D006801:Humans; D007764:Lacquer / Q000009:adverse effects*; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology; D008074:Lipoproteins / Q000097:blood / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced / Q000517:prevention & control*; D016273:Occupational Exposure / Q000009:adverse effects; D010150:Paint / Q000009:adverse effects*; D012016:Reference Values; D014451:Ubiquinone / Q000008:administration & dosage*
D008074:Lipoproteins; D014451:Ubiquinone