Proton magnetic resonance spectroscopy in primary blepharospasm.
Single-volume proton magnetic resonance spectroscopy, localized to basal ganglia, was carried out in 10 patients with primary blepharospasm (PB) to assess the levels of N-acetyl aspartate (NAA), creatine-phosphocreatine, and choline-containing compounds. NAA was reduced significantly in patients compared with control subjects. This result suggests a striatal neuronal loss in PB.
Federico
F
F
Department of Neurology and Psychiatry, University of Bari, Italy.
Simone
I L
IL
Lucivero
V
V
Defazio
G
G
De Salvia
R
R
Mezzapesa
D M
DM
Petruzzellis
M
M
Tortorella
C
C
Livrea
P
P
D000368:Aged; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000032:analysis; D001479:Basal Ganglia / Q000737:chemistry*; D001764:Blepharospasm / Q000175:diagnosis*; D002794:Choline / Q000032:analysis; D003401:Creatine / Q000032:analysis; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D010725:Phosphocreatine / Q000032:analysis
D010725:Phosphocreatine; D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline