The GalR2 galanin receptor mediates galanin-induced jejunal contraction, but not feeding behavior, in the rat: differentiation of central and peripheral effects of receptor subtype activation.
The neuropeptide galanin mediates a diverse array of physiological functions through activation of specific receptors. Roles of the three recently cloned galanin receptors (GalRs) in rat intestinal contraction and food intake were examined using GalR-selective ligands and the results were compared with the pharmacological profiles of defined GalRs. The action profile of these ligands in jejunal contraction resembled only that of GalR2 and only a high level of GalR2 mRNA was detected in the tissue, supporting GalR2 as the receptor mediating jejunal contraction. The action profile for food intake in rats excluded GalR2, GalR3 and the putative pituitary galanin receptor as the 'feeding receptor', suggesting that either GalR1 or an unidentified GalR is responsible for mediating this function.
Wang
S
S
Department of CNS/CV Biological Research, Schering-Plough Research Institute, Kenilworth, NJ 07033, USA. suke.wang@spcorp.com
Ghibaudi
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L
Hashemi
T
T
He
C
C
Strader
C
C
Bayne
M
M
Davis
H
H
Hwa
J J
JJ
D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D005247:Feeding Behavior / Q000502:physiology*; D019004:Galanin / Q000502:physiology*; D007457:Iodine Radioisotopes; D007583:Jejunum / Q000502:physiology*; D008297:Male; D009119:Muscle Contraction / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D044088:Receptors, Galanin; D018013:Receptors, Neuropeptide / Q000819:agonists / Q000145:classification / Q000502:physiology*; D011994:Recombinant Proteins / Q000378:metabolism; D013552:Swine
D007457:Iodine Radioisotopes; D044088:Receptors, Galanin; D018013:Receptors, Neuropeptide; D011994:Recombinant Proteins; D019004:Galanin