title: The uncertainty associated with the predictive value of test results.
abstract: The uncertainty associated with predictive value of test results was taken into consideration, as concerns both sampling error (related to the size of the statistical reference samples) and analytical imprecision (unavoidably involved by the measurement itself). A software package, developed for the statistical calculations, was used for the treatment of the results obtained for serum free thyroxin in euthyroid and dysthyroid subjects, assumed as an experimental model. Examples are shown for the obtainable functions predictive value vs. estimate and the related uncertainty regions. These data could help in comparing test results and, in particular, in preparing fully informative laboratory reports. The difficulties involved by an extensive application of the procedure are discussed.
authors.affiliation: PROMM, Ospedale Mauriziano, Torino, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Malvano
authors.forename: A
authors.initials: A
authors.lastname: Chiecchio
authors.forename: M
authors.initials: M
authors.lastname: Borsa
authors.forename: G
authors.initials: G
authors.lastname: Messeri
mesh_terms: D006801:Humans; D016013:Likelihood Functions; D015233:Models, Statistical; D011237:Predictive Value of Tests; D011336:Probability; D015203:Reproducibility of Results; D015983:Selection Bias; D012984:Software; D013974:Thyroxine / Q000097:blood
chemical_list: D013974:Thyroxine