Paraneoplastic optic neuropathy and autoantibody production in small-cell carcinoma of the lung.
A 59-year-old woman presented with acute-onset, bilateral, painless loss of vision, dysarthria, and ataxia. Ophthalmoscopy showed bilateral optic disc edema. A magnetic resonance scan of the head was normal. Chest radiography showed mediastinal adenopathy. Mediastinoscopy and biopsy identified small-cell carcinoma of the lung. An autoantibody to optic nerve and retina was demonstrated in the patient's serum. An electroretinogram was normal. The patient was diagnosed with a paraneoplastic optic neuropathy and paraneoplastic cerebellar syndrome. After treatment for her lung cancer, the patient remains stable from a visual and neurologic standpoint.
Luiz
J E
JE
Department of Ophthalmology, Baylor College of Medicine, Houston, Texas, USA.
Lee
A G
AG
Keltner
J L
JL
Thirkill
C E
CE
Lai
E C
EC
D000208:Acute Disease; D001323:Autoantibodies / Q000032:analysis*; D018288:Carcinoma, Small Cell / Q000276:immunology / Q000473:pathology*; D004596:Electroretinography; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000276:immunology / Q000473:pathology*; D008875:Middle Aged; D009900:Optic Nerve / Q000276:immunology; D009901:Optic Nerve Diseases / Q000175:diagnosis* / Q000276:immunology; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000276:immunology; D012160:Retina / Q000276:immunology; D014786:Vision Disorders / Q000175:diagnosis; D014794:Visual Fields
D001323:Autoantibodies