title: Hematometra secondary to anticoagulant rodenticide toxicity.
abstract: An adult, intact female Australian shepherd presented for frank vaginal bleeding of unknown duration. The only coagulation profile abnormality upon presentation was mild prolongation of the partial thromboplastin time (PTT). The uterus was removed at surgery and contained a large amount of coagulated blood. Clotting profiles were markedly abnormal 48 hours postoperatively. Serum analysis was positive for brodifacoum, an anticoagulant rodenticide. Preoperative coagulation was most likely normalized by vitamin K1 therapy administered prior to presentation. The only manifestation of anticoagulant rodenticide was hematometra. Rodenticide intoxication should be considered in the differential diagnosis list of hematometra or metrorrhagia.
authors.affiliation: Department of Veterinary Clinical Sciences, Washington State University, Pullman 99164-6610, USA.
authors.forename: S L
authors.initials: SL
authors.lastname: Padgett
authors.forename: J E
authors.initials: JE
authors.lastname: Stokes
authors.forename: R L
authors.initials: RL
authors.lastname: Tucker
authors.forename: L G
authors.initials: LG
authors.lastname: Wheaton
mesh_terms: D015110:4-Hydroxycoumarins / Q000506:poisoning*; D000818:Animals; D001780:Blood Coagulation Tests / Q000662:veterinary; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000139:chemically induced* / Q000601:surgery; D004285:Dogs; D005260:Female; D006409:Hematometra / Q000139:chemically induced / Q000601:surgery / Q000662:veterinary*; D006490:Hemostatics / Q000627:therapeutic use; D012378:Rodenticides / Q000506:poisoning*; D014463:Ultrasonography; D014592:Uterine Hemorrhage / Q000139:chemically induced / Q000601:surgery / Q000662:veterinary*; D014599:Uterus / Q000000981:diagnostic imaging / Q000601:surgery; D014812:Vitamin K / Q000627:therapeutic use
chemical_list: D015110:4-Hydroxycoumarins; D006490:Hemostatics; D012378:Rodenticides; D014812:Vitamin K; C013418:bromfenacoum