title: Adrenocortical and metabolic responses to dobutamine infusion during halothane anaesthesia in ponies.
abstract: The study investigated whether hypotension in halothane-anaesthetised ponies is the stimulus inducing an endocrine stress response by assessing the effect of maintenance of normotension with a dobutamine infusion. Groups of six ponies were studied. After premedication with acepromazine (0.04 mg/kg) anaesthesia was induced with thiopentone (10 mg/kg) and maintained for 120 min with halothane (group AN). Dobutamine was infused to effect (1.1-4.4 microg/kg/min) to maintain arterial pressure at pre anaesthetic levels. The conscious group (CON) were prepared as for AN and then received only dobutamine infusion 1.0 microg/kg/min for 120 min. Arterial blood pressure, pH, oxygen and carbon dioxide tension, pulse rate, haematocrit, and plasma cortisol, glucose and lactate concentrations were measured before, at 20 min intervals during anaesthesia, and 20 and 120 min after anaesthesia ceased. Blood pressure remained close to control in both groups. The AN group became hypercapnic and acidotic, pulse rate and haematocrit increased, cortisol increased more than twofold and plasma glucose and lactate did not change. All values remained at control in the CON group except for small increases in haematocrit and decreases in pulse rate. Maintenance of normotension during halothane anaesthesia did not blunt the adrenocortical response to anaesthesia nor did the same dose of dobutamine alone increase plasma cortisol. Hypotension appears not to be the sole stimulus to equine adrenocortical activity during halothane anaesthesia.
authors.affiliation: Department of Clinical Veterinary Medicine, University of Cambridge, UK.
authors.forename: P M
authors.initials: PM
authors.lastname: Taylor
mesh_terms: D000318:Adrenergic beta-Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D000758:Anesthesia / Q000009:adverse effects / Q000662:veterinary*; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects; D004280:Dobutamine / Q000008:administration & dosage / Q000494:pharmacology*; D006221:Halothane / Q000009:adverse effects; D006400:Hematocrit / Q000662:veterinary; D006736:Horses / Q000097:blood / Q000378:metabolism*; D006854:Hydrocortisone / Q000097:blood*; D007022:Hypotension / Q000517:prevention & control / Q000662:veterinary*; D007262:Infusions, Intravenous / Q000662:veterinary; D019344:Lactic Acid / Q000097:blood; D008297:Male
chemical_list: D000318:Adrenergic beta-Agonists; D001786:Blood Glucose; D019344:Lactic Acid; D004280:Dobutamine; D006221:Halothane; D006854:Hydrocortisone