Nephropathy and hypertension as manifestations in a 13-y-old girl with primary antiphospholipid syndrome.
Severe renal hypertension due to both unilateral renal arterial occlusion and renal thrombotic microangiopathy developed in a 13-y-old girl as a manifestation of primary antiphospholipid antibody syndrome. The combination of the intravenous high-dose urokinase therapy and oral anticoagulation therapy, comprising aspirin, warfarin and dipyridamole, was significantly effective in improving her renal function and preventing thrombotic events during an 18-month follow-up period.
Ohtomo
Y
Y
Department of Paediatrics, Juntendo University School of Medicine, Tokyo, Japan.
Matsubara
T
T
Nishizawa
K
K
Unno
A
A
Motohashi
T
T
Yamashiro
Y
Y
D000293:Adolescent; D000925:Anticoagulants / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006978:Hypertension, Renovascular / Q000188:drug therapy / Q000209:etiology*; D010960:Plasminogen Activators / Q000627:therapeutic use; D012078:Renal Artery Obstruction / Q000209:etiology*; D013927:Thrombosis / Q000209:etiology*; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use
D000925:Anticoagulants; D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator