Hyperglycemia is a factor for an increase in serum ceruloplasmin in type 2 diabetes.
OBJECTIVE
To examine if there is a correlation between high blood glucose and serum ceruloplasmin (Cp) levels.


METHODS
Serum Cp levels were measured in 637 patients with type 2 diabetes (all type 2 diabetes group). For the follow-up type 2 diabetes group, 161 patients who had not had any changes in their situation during the last year that are known to influence serum Cp levels were reexamined 1 year later. The control group was composed of 158 healthy individuals. Serum Cp and blood HbA1c levels were measured by radial immunodiffusion and high-performance liquid chromatography assays, respectively.


RESULTS
Serum Cp levels in the all type 2 diabetes group were significantly higher than those in the control group (P < 0.0001), although the serum Cp levels did not correlate with the blood HbA1c levels in the all type 2 diabetes group (r = 0.055, P = 0.351). Then we evaluated those factors (delta-log Cp and delta-HbA1c) in the follow-up type 2 diabetes group to minimize changes from the genetic differences and to exclude any known factors influencing serum Cp levels. This indicated that the delta-HbA1c had a positive correlation to the delta-log Cp (r = 0.304, P < 0.0001).


CONCLUSIONS
A persistent high blood glucose (namely HbA1c) is associated with an increase in serum Cp levels over 1 year.
Daimon
M
M
Third Department of Internal Medicine, Yamagata University, School of Medicine, Japan. mdaimon@med.id.yamagata-u.ac.jp
Susa
S
S
Yamatani
K
K
Manaka
H
H
Hama
K
K
Kimura
M
M
Ohnuma
H
H
Kato
T
T
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D002570:Ceruloplasmin / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications*; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000150:complications*; D008297:Male; D008875:Middle Aged
D001786:Blood Glucose; D002570:Ceruloplasmin; D006442:Glycated Hemoglobin