title: [Familial hemiplegic migraine].
abstract: Familial hemiplegic migraine (FHM) is a rare subtype of migraine with aura. It is inherited as an autosomal dominant trait. A gene for FHM has been assigned to chromosome 19. This gene codes for a brain-specific calcium channel, and is responsible for FHM in 55% of the FHM families. Other FHM families have been linked to two different locations on chromosome 1. These locations contain possible candidate genes coding for calcium-and potassium channels. Thus FHM is a genetically heterogenous ion channel disorder, which is caused by at least three different genes. About 29% of the FHM families also have cerebellar ataxia, these families have all been linked to chromosome 19. The identification of the genes for FHM may be a key to the identification of the gene/genes for migraine with and without aura.
authors.affiliation: Neurologisk afdeling, Amtssygehuset i Glostrup.
authors.forename: L L
authors.initials: LL
authors.lastname: Thomsen
authors.forename: J
authors.initials: J
authors.lastname: Olesen
authors.forename: M B
authors.initials: MB
authors.lastname: Russell
mesh_terms: D002874:Chromosome Mapping; D005260:Female; D006429:Hemiplegia / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D010375:Pedigree