Controlled chemical modification of hyaluronic acid: synthesis, applications, and biodegradation of hydrazide derivatives.
Controlled modification of the carboxylic acid moieties of hyaluronic acid with mono- and polyfunctional hydrazides leads to biochemical probes, biopolymers with altered physical and chemical properties, tethered drugs for controlled release, and crosslinked hydrogels as biocompatible scaffoldings for tissue engineering. Methods for polyhydrazide synthesis, for prodrug preparation, for hydrogel crosslinking, and for monitoring biodegradation are described.
Prestwich
G D
GD
Department of Medicinal Chemistry, The University of Utah, Salt Lake City 84112, USA. gprestwich@deans.pharm.utah.edu
Marecak
D M
DM
Marecek
J F
JF
Vercruysse
K P
KP
Ziebell
M R
MR
D001672:Biocompatible Materials; D001673:Biodegradation, Environmental; D003432:Cross-Linking Reagents / Q000737:chemistry; D006820:Hyaluronic Acid / Q000138:chemical synthesis / Q000737:chemistry*; D006835:Hydrazones / Q000737:chemistry*; D015394:Molecular Structure; D013057:Spectrum Analysis
D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D006835:Hydrazones; D006820:Hyaluronic Acid