Slow release polymer-drug systems obtained by moisture promoted polyreactions. 1. Codeine resinate encapsulated in poly(alkyl alpha-cyanoacrylates).
Samples of codeine resinate consisting of a carboxylic cation exchanger (as a polymeric carrier) and codeine (as a drug) were coated with poly(alkyl alpha-cyanoacrylates) by suspending and stirring wet resinate beads in a toluene solution of the monomer. Methyl, ethyl and n-butyl alpha-cyanoacrylates were used as monomers. Each coated material released codeine more slowly than the non-coated. The data obtained confirmed that water promoted the polymerization of alkyl alpha-cyanoacrylates, which proceeded at the surface of the wet resinate beads. The rate of codeine release depended on the type of monomer used for coating, the monomer/resinate feed ratio and the plymerization time.
Lukaszczyk
J
J
Silesian Technical University, Department of Physical Chemistry and Technology of Polymers, Gliwice, Poland.
Urbaś
P
P
D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000737:chemistry*; D002214:Capsules; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003061:Codeine / Q000008:administration & dosage / Q000737:chemistry*; D003487:Cyanoacrylates / Q000008:administration & dosage / Q000737:chemistry*; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D007700:Kinetics; D011108:Polymers / Q000008:administration & dosage / Q000737:chemistry
D000701:Analgesics, Opioid; D002214:Capsules; D003487:Cyanoacrylates; D003692:Delayed-Action Preparations; D011108:Polymers; D003061:Codeine