Indole alkaloids from the tunicate Aplidium meridianum.
Five new indole alkaloids, meridianins A-E (1-5), have been isolated from the tunicate Aplidium meridianum, which was collected at a depth of 100 m near the South Georgia Islands, and their structures were elucidated by spectroscopic techniques. Compounds 2-5 showed cytotoxicity toward murine tumor cell lines.
Franco
L H
LH
Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón II, Ciudad Universitaria, (1428) Buenos Aires, Argentina.
Joffé
E B
EB
Puricelli
L
L
Tatian
M
M
Seldes
A M
AM
Palermo
J A
JA
D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured; D014561:Urochordata / Q000378:metabolism*
D000470:Alkaloids; D000970:Antineoplastic Agents