Segregation analysis of idiopathic talipes equinovarus in a Texan population.
"Idiopathic" talipes equinovarus (ITEV) is a nonsyndromal congenital anomaly of one or both feet. Casting and surgery are often necessary to obtain correct foot alignment. In spite of treatment, residual deformities of the feet occur and calf muscles may be hypoplastic. The cause of ITEV is unknown but genetic factors have been postulated. Complex segregation analysis was performed on 173 ITEV families including 93 Caucasian and 48 Hispanic families. The recessive mixed model was the best fitting model and no differences were found based on ethnicity. These results confirm previous studies suggesting that there is a genetic component to the development of ITEV.
de Andrade
M
M
University of Texas M.D. Anderson Cancer Center, Houston, USA.
Barnholtz
J S
JS
Amos
C I
CI
Lochmiller
C
C
Scott
A
A
Risman
M
M
Hecht
J T
JT
D003025:Clubfoot / Q000453:epidemiology* / Q000208:ethnology / Q000235:genetics*; D003627:Data Interpretation, Statistical; D005190:Family; D005260:Female; D005799:Genes, Dominant; D005808:Genes, Recessive; D006801:Humans; D008297:Male; D015233:Models, Statistical; D010375:Pedigree; D017678:Sex Distribution; D013781:Texas / Q000453:epidemiology