[Changes in the blastogenic lymphocyte transformation during kindling induced by picrotoxin in rats].
Picrotoxin-induced kindling was shown to suppress the blastogenic response to bacterial lipopolysaccharide and phytogemagglutinin in male Wistar rats. The delta-sleep-inducing peptide as well as carbamazepine prevented the epileptogenic effects of picrotoxin. Carbamazepine was also effective against decreasing of phytogemagglutinin-induced blastogenic response.
Brusentsov
A I
AI
State Medical University, Odessa, Ukraine.
Moroz
V V
VV
Suprun
S A
SA
Pomazanova
T N
TN
Shandra
A A
AA
Godlevskiĭ
L S
LS
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D002220:Carbamazepine / Q000494:pharmacology; D003292:Convulsants / Q000633:toxicity*; D003701:Delta Sleep-Inducing Peptide / Q000494:pharmacology; D004827:Epilepsy / Q000276:immunology / Q000473:pathology*; D007696:Kindling, Neurologic; D008070:Lipopolysaccharides / Q000633:toxicity; D008213:Lymphocyte Activation / Q000276:immunology; D008297:Male; D010835:Phytohemagglutinins / Q000276:immunology; D010852:Picrotoxin / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
D000927:Anticonvulsants; D002220:Carbamazepine; D003292:Convulsants; D003701:Delta Sleep-Inducing Peptide; D008070:Lipopolysaccharides; D010835:Phytohemagglutinins; D010852:Picrotoxin