Selenium-dependent and selenium-non-dependent glutathione peroxidase in patients with Balkan endemic nephropathy.
We studied the activity of erythrocyte selenium (Se)-dependent, Se-non-dependent glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) in uremic patients (UP) in clinically healthy members from families affected with Balkan nephropathy (HMF/BEN) and in healthy volunteers from endemic settlements (control group). The SOD activity was not significantly different in the groups studied and the Se-non-dependent GSH-Px activity in HMF/BEN and UP was not different from the control group. However, the activity of Se-dependent GSH-Px in UP was lower compared with the control group, whereas the mean value of the Se-dependent GSH-Px activity in HMF/BEN was not significantly different when compared with the other two investigated groups.
Grubor-Lajsic
G
G
Institute of Biology, Faculty of Sciences, University of Novi Sad, Yugoslavia.
Djordjević
V B
VB
Jovanovic-Galović
A
A
Lecić
N
N
Djordjević
V
V
Spasić
M
M
D001449:Balkan Nephropathy / Q000097:blood / Q000201:enzymology* / Q000503:physiopathology; D003404:Creatinine / Q000097:blood; D004912:Erythrocytes / Q000201:enzymology; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D012643:Selenium / Q000097:blood*; D013482:Superoxide Dismutase / Q000097:blood; D014508:Urea / Q000097:blood
D014508:Urea; D003404:Creatinine; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D012643:Selenium