Association of extracellular-superoxide dismutase phenotype with the endothelial constitutive nitric oxide synthase polymorphism.
The distribution of extracellular-superoxide dismutase (EC-SOD) levels in healthy Australian subjects was consistent with two distinct phenotypes in which the smaller group of subjects (3.3%) had 15-fold higher levels. The EC-SOD levels in individuals homozygous for endothelial constitutive nitric oxide synthase 4a (ecNOS4a), a rare allele for ecNOS repeat polymorphism at intron 4, were significantly lower than those in ecNOS4A/a and ecNOS4AIA subjects. Furthermore, NO levels were negatively correlated with the EC-SOD levels in common EC-SOD phenotype subjects. Whilst the mechanism remains speculative, it is possible that there is a significant interaction between EC-SOD and ecNOS, or that common factor(s), either genetic or environmental, influence both of them.
Adachi
T
T
Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Japan. adachi@gifu-pu.ac.jp
Wang
X L
XL
D000293:Adolescent; D000328:Adult; D000483:Alleles; D001315:Australia; D002648:Child; D004730:Endothelium, Vascular / Q000201:enzymology*; D005110:Extracellular Space / Q000201:enzymology*; D005260:Female; D006801:Humans; D007438:Introns; D008297:Male; D009569:Nitric Oxide / Q000097:blood; D019001:Nitric Oxide Synthase / Q000235:genetics*; D052250:Nitric Oxide Synthase Type III; D010641:Phenotype; D011110:Polymorphism, Genetic; D012091:Repetitive Sequences, Nucleic Acid; D013482:Superoxide Dismutase / Q000097:blood*
D009569:Nitric Oxide; C496314:NOS3 protein, human; D019001:Nitric Oxide Synthase; D052250:Nitric Oxide Synthase Type III; D013482:Superoxide Dismutase