Identification of crystals in kidneys of AIDS patients treated with foscarnet.
Three acquired immune deficiency syndrome patients given foscarnet to treat cytomegalovirus retinitis developed renal failure with crystal deposits within the renal glomeruli. We identified these crystals as a mixture of sodium salt, calcium salt, and a mixed salt containing both sodium and calcium ions. This composition has not been previously reported. Foscarnet can complex available ionized calcium and secondarily precipitate in glomeruli. The percentage of complexing depends on calcium concentration in serum and the poor calcium salt solubility.
Maurice-Estepa
L
L
Service de Biochimie A and INSERM U 423, Hôpital Necker-Enfants Malades, Paris, France.
Daudon
M
M
Katlama
C
C
Jouanneau
C
C
Sazdovitch
V
V
Lacour
B
B
Beaufils
H
H
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy* / Q000473:pathology; D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000473:pathology; D000328:Adult; D000998:Antiviral Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003460:Crystallization; D017726:Cytomegalovirus Retinitis / Q000188:drug therapy* / Q000473:pathology; D017809:Fatal Outcome; D017245:Foscarnet / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007678:Kidney Glomerulus / Q000187:drug effects / Q000473:pathology; D008297:Male; D018613:Microscopy, Confocal; D008875:Middle Aged; D051437:Renal Insufficiency / Q000139:chemically induced* / Q000473:pathology; D017550:Spectroscopy, Fourier Transform Infrared
D000998:Antiviral Agents; D017245:Foscarnet