title: Inhibition of long-term potentiation in developing rat visual cortex but not hippocampus by in utero exposure to polychlorinated biphenyls.
abstract: The neurotoxic potential of polychlorinated biphenyls (PCBs) depends on the structure of the congener as well as on the age of the exposure. We exposed rats prenatally to a coplanar congener (PCB-77) or to a non-coplanar congener (PCB-47) and measured the amount of long-term potentiation (LTP) at postnatal days 11-19 in the visual cortex and hippocampus. While PCB-77 exposure affected LTP statistically significantly in cortical but not hippocampal slices, the exposure to PCB-47 was much less effective.
authors.affiliation: Medical Institute of Environmental Hygiene, Heinrich-Heine-Univ. Düsseldorf, Department of Neurotoxicology, Auf'm Hennekamp 50, D-40225, Düsseldorf, Germany. altmannl@rz.uni-duesseldorf.de
authors.forename: L
authors.initials: L
authors.lastname: Altmann
authors.forename: H
authors.initials: H
authors.lastname: Lilienthal
authors.forename: J
authors.initials: J
authors.lastname: Hany
authors.forename: H
authors.initials: H
authors.lastname: Wiegand
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D004558:Electric Stimulation; D005260:Female; D006624:Hippocampus / Q000196:embryology / Q000254:growth & development / Q000502:physiology*; D017774:Long-Term Potentiation / Q000187:drug effects / Q000502:physiology*; D011078:Polychlorinated Biphenyls / Q000494:pharmacology* / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D020318:Rats, Long-Evans; D014793:Visual Cortex / Q000196:embryology / Q000254:growth & development / Q000502:physiology*
chemical_list: D011078:Polychlorinated Biphenyls; C028451:3,4,3',4'-tetrachlorobiphenyl