Antigen presentation: coming out gracefully.
Efficient assembly of antigen-presenting class I MHC molecules requires the formation of a complex between the class I molecule and the TAP peptide transporter. The complex has been found to contain an additional four proteins, which help to ensure optimal peptide loading onto the class I molecules.
Lehner
P J
PJ
Wellcome Trust, Department of Pathology, Cambridge, UK. pjl30@hermes.cam.ac.uk
Trowsdale
J
J
D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D018528:ATP-Binding Cassette Transporters / Q000378:metabolism; D000818:Animals; D017951:Antigen Presentation / Q000502:physiology*; D006360:Heat-Shock Proteins / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D007535:Isomerases / Q000378:metabolism; D019704:Protein Disulfide-Isomerases
D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D018528:ATP-Binding Cassette Transporters; D006360:Heat-Shock Proteins; D015395:Histocompatibility Antigens Class I; C073119:TAP1 protein, human; D007535:Isomerases; D019704:Protein Disulfide-Isomerases; C085868:PDIA3 protein, human