Glutathione S-transferases and prevention of cellular free radical damage.
This paper describes the intervention of glutathione-dependent enzymes, in particular the glutathione S-transferases (GSTs), in both the detoxication of electrophilic decomposition products resulting from the attack of oxygen radicals on lipids and DNA; and the prevention of oxygen toxicity generated by redox cycling catecholamine derivatives. The continuing growth of our knowledge of the glutathione S-transferase polygene family is described in terms of the increase in members of known gene families, the discovery of new ones and our increasing knowledge of their activities towards endogenous substrates.
Ketterer
B
B
Department of Oncology, University College Medical School, London, UK. b.ketterer@ucl.ac.uk
D000447:Aldehydes / Q000378:metabolism; D000818:Animals; D002395:Catecholamines / Q000378:metabolism; D004249:DNA Damage; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000378:metabolism; D005609:Free Radicals / Q000378:metabolism / Q000633:toxicity; D005982:Glutathione Transferase / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation; D018377:Neurotransmitter Agents / Q000378:metabolism; D010743:Phospholipids / Q000737:chemistry / Q000378:metabolism*; D011110:Polymorphism, Genetic; D017382:Reactive Oxygen Species / Q000378:metabolism*
D000447:Aldehydes; D002395:Catecholamines; D005231:Fatty Acids, Unsaturated; D005609:Free Radicals; D018377:Neurotransmitter Agents; D010743:Phospholipids; D017382:Reactive Oxygen Species; D005982:Glutathione Transferase; C027576:4-hydroxy-2-nonenal