New types of liposidomycins that inhibit bacterial peptidoglycan synthesis and are produced by Streptomyces. II. Isolation and structure elucidation.
Various new liposidomycins were isolated from a culture of the strain Streptomyces sp. SN-1061M by changing medium components and they were classified into four types (I-IV) based on their structures. They were purified by butanol extraction, silica gel and LH-20 column chromatographies, and high performance liquid chromatography on ODS columns. Type (I) has the original structure which has sulfate and 3-methylglutaric acid moieties. Type (II) has no 3-methylglutaric acid moiety and type (III) has no sulfate moiety. Type (IV) has neither moiety. Type (III) and (IV) compounds, which have no sulfate moiety, exhibited more potent antimicrobial activity.
Kimura
K
K
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd., Tochigi, Japan.
Ikeda
Y
Y
Kagami
S
S
Yoshihama
M
M
Ubukata
M
M
Esumi
Y
Y
Osada
H
H
Isono
K
K
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D015169:Colony Count, Microbial; D003470:Culture Media; D004926:Escherichia coli / Q000187:drug effects; D013058:Mass Spectrometry; D009168:Mycobacterium phlei / Q000187:drug effects; D010457:Peptidoglycan / Q000096:biosynthesis*; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000737:chemistry* / Q000378:metabolism
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D003470:Culture Media; D010457:Peptidoglycan; C047544:liposidomycins