title: Pyridines and pyrazolines from salicylic acid derivatives with propenone residue and their antimicrobial properties.
abstract: Reaction of the propenones 1c, d with chlorosulfonyl isocyanate followed by hydrolysis gave the corresponding carbamoyloxybenzoates 2a, b. While their reaction with ethyl isocyanate afforded the 1,3-benzoxazine-2,4-diones 3a, b. Reaction of 1a, b with aryl hydrazines gave the pyrazolines 4a, d, whereas, with hydrazine hydrate in acetic acid, the acetyl derivatives 4e, f were produced. 1c, d reacted with malononitrile and ethyl cyanoacetate affording the cyanopyridines 5 and cyanopyridones 6 respectively. The products show antimicrobial activities.
authors.affiliation: National Research Centre, Dokki, Cairo, Egypt.
authors.forename: N
authors.initials: N
authors.lastname: Grant
authors.forename: N
authors.initials: N
authors.lastname: Mishriky
authors.forename: F M
authors.initials: FM
authors.lastname: Asaad
authors.forename: N G
authors.initials: NG
authors.lastname: Fawzy
mesh_terms: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D012459:Salicylates / Q000138:chemical synthesis* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D011720:Pyrazoles; D011725:Pyridines; D012459:Salicylates