title: Induction of endogenous mammary tumor virus in lymphocytes infected with murine acquired immunodeficiency syndrome virus.
abstract: Mice infected with murine acquired immunodeficiency syndrome (MAIDS) virus developed lymphoadenopathy and profound immunodeficiency. Concomitantly the expression of endogenous mammary tumor virus (MTV) mRNA increased significantly, especially for the 1.7-kb 3' open reading frame (ORF) mRNA encoding MTV superantigen. B cell lines that are established from MAIDS mice and exhibit superantigen activity also express a high level of 1.7-kb endogenous MTV and mRNA. Infection of a B cell tumor line in vitro with retrovirus containing the cloned MAIDS virus gene induced superantigen activity and this cell line also expressed the 1.7-kb superantigen coding MTV 3' ORF mRNA. These results strongly suggest a link between MAIDS virus infection and the induction of endogenous superantigen activity. This may play an important role in the pathogenesis of the MAIDS virus.
authors.affiliation: Department of Pathology and Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
authors.forename: S
authors.initials: S
authors.lastname: Gayama
authors.forename: L
authors.initials: L
authors.lastname: Doyon
authors.forename: B
authors.initials: B
authors.lastname: Vaupel
authors.forename: R P
authors.initials: RP
authors.lastname: Sekaly
authors.forename: O
authors.initials: O
authors.lastname: Kanagawa
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D015750:Genes, gag; D008214:Lymphocytes / Q000821:virology*; D016393:Lymphoma, B-Cell / Q000821:virology; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D016183:Murine Acquired Immunodeficiency Syndrome / Q000821:virology*; D016366:Open Reading Frames; D012333:RNA, Messenger / Q000032:analysis; D013154:Spleen / Q000821:virology; D018089:Superantigens / Q000032:analysis / Q000096:biosynthesis; D014407:Tumor Cells, Cultured
chemical_list: D012333:RNA, Messenger; D018089:Superantigens