title: Manganese induced parkinsonism: a case report.
abstract: Manganese (Mn) intoxication is known to induce parkinsonism. Mn-induced parkinsonism preferentially affect the globus pallidus in contrast to idiopathic parkinsonism where degeneration predominantly involves the nigral pars compacta. We describe a 51-year-old man who had been occupationally exposed to Mn. He had parkinsonian features including masked face, resting tremor, and bradykinesia. He also had a cock walk and a particular propensity to fall in a backward gait. There was no sustained therapeutic response to levodopa. A fluorodopa PET scan was normal. This case indicates that Mn-induced parkinsonism can be differentiated from idiopathic parkinsonism in that the former has unique clinical features and a normal fluorodopa PET scan.
authors.affiliation: Department of Neurology, Dong-A University College of Medicine, Pusan, Korea. jwkim1@seunghak.donga.ac.kr
authors.forename: J W
authors.initials: JW
authors.lastname: Kim
authors.forename: Y
authors.initials: Y
authors.lastname: Kim
authors.forename: H K
authors.initials: HK
authors.lastname: Cheong
authors.forename: K
authors.initials: K
authors.lastname: Ito
mesh_terms: D006801:Humans; D008297:Male; D008345:Manganese; D008875:Middle Aged; D010302:Parkinson Disease, Secondary / Q000139:chemically induced* / Q000000981:diagnostic imaging; D011859:Radiography; D014055:Tomography, Emission-Computed
chemical_list: D008345:Manganese