Effective, nonsensitizing vaccination with culture filtrate proteins against virulent Mycobacterium bovis infections in mice.
Vaccination of mice with Mycobacterium bovis culture filtrate proteins (CFP), prepared in a variety of adjuvants (aluminum hydroxide, Quil-A, and dimethyldioctyldecyl ammonium bromide [DDA]), provided significant protection against an aerosol challenge of virulent M. bovis. Additionally, vaccination with CFP in DDA or Quil-A did not sensitize mice to M. bovis purified protein derivative.
Bosio
C M
CM
Mycobacterial Research Laboratories, Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523, USA. bosio@cber.fda.gov
Orme
I M
IM
D000818:Animals; D001500:BCG Vaccine / Q000276:immunology; D001426:Bacterial Proteins / Q000276:immunology*; D006968:Hypersensitivity, Delayed; D008297:Male; D051379:Mice; D009163:Mycobacterium bovis / Q000276:immunology* / Q000472:pathogenicity; D014376:Tuberculosis / Q000517:prevention & control*; D014611:Vaccination
D001500:BCG Vaccine; D001426:Bacterial Proteins