Common threads in eukaryotic circadian systems.
Within the past 18 months, common regulatory patterns have emerged among eukaryotic circadian systems--extending from fungi through to mammals. Heterodimeric complexes of PAS-domain-containing transcription factors play positive roles in clock-associated feedback loops, and classic clock proteins like FREQUENCY (FRQ), PERIOD (PER), and TIMELESS (TIM) appear as negative elements. Post-transcriptional control governs the amount and type of FRQ and makes the clock responsive to temperature.
Dunlap
J C
JC
Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA. jay.c.dunlap@dartmouth.edu
D000818:Animals; D002940:Circadian Rhythm; D005057:Eukaryotic Cells