title: Oesophageal dysmotility is not associated with poor outcome after laparoscopic Nissen fundoplication.
abstract: BACKGROUND
  Nissen fundoplication has become the standard operation in the surgical management of gastro-oesophageal reflux disease. Postoperative dysphagia is thought to occur more commonly in patients with oesophageal dysmotility and it has been recommended that fundoplication be modified or avoided in these patients. The aim of this study was to determine the outcome of patients with normal motility and dysmotility undergoing laparoscopic Nissen fundoplication.
  
  
  METHODS
  This was a single-centre prospective cohort study with 1-year follow-up, using dysphagia as the main outcome variable. Of 81 patients who underwent laparoscopic surgery, 48 had normal motility and 33 had oesophageal dysmotility (defined as percentage peristalsis, using ten wet swallows, of 50 per cent or less and/or a mean distal pressure of less than 40 mmHg).
  
  
  RESULTS
  Dysphagia was present before operation in 14 of 48 patients with normal motility and 15 of 33 in the dysmotility group (P=0.2). At 3-month follow-up, new or worse dysphagia was present in 13 of 48 patients in the normal group and four of 33 in the dysmotility group (P=0.17). At 1 year the incidence of dysphagia was six of 48 in the normal group and five of 33 in the dysmotility group (P=0.9).
  
  
  CONCLUSIONS
  Preoperative manometric assessment of oesophageal motility does not correlate with postoperative outcome, and oesophageal dysmotility should not be regarded as a contraindication to laparoscopic Nissen fundoplication.
authors.affiliation: Department of Surgery, Queen's Medical Centre, Nottingham, UK.
authors.forename: I J
authors.initials: IJ
authors.lastname: Beckingham
authors.forename: A K
authors.initials: AK
authors.lastname: Cariem
authors.forename: P C
authors.initials: PC
authors.lastname: Bornman
authors.forename: M D
authors.initials: MD
authors.lastname: Callanan
authors.forename: J A
authors.initials: JA
authors.lastname: Louw
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003680:Deglutition Disorders / Q000209:etiology; D005260:Female; D018662:Fundoplication / Q000379:methods*; D005764:Gastroesophageal Reflux / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010535:Laparoscopy / Q000379:methods*; D008297:Male; D008365:Manometry; D008875:Middle Aged; D011446:Prospective Studies; D016896:Treatment Outcome