title: Characterization of psoralen-oleic acid cycloadducts and their possible involvement in membrane photodamage.
abstract: By UVA irradiation of an ethanol solution of psoralen and oleic acid, four main photoproducts have been isolated and characterized: two have cis,cis structure; the other two are trans,cis. The same adducts have been isolated from the photoreaction of psoralen with beta-oleoyl-gamma-stearoyl-1-alpha-phosphatidylcholine followed by enzymatic hydrolysis with phospholipase A2. The four isomers stimulate protein kinase C to almost the same extent.
authors.affiliation: Department of Pharmaceutical Sciences, University of Padua, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Frank
authors.forename: S
authors.initials: S
authors.lastname: Caffieri
authors.forename: A
authors.initials: A
authors.lastname: Raffaelli
authors.forename: D
authors.initials: D
authors.lastname: Vedaldi
authors.forename: F
authors.initials: F
authors.lastname: Dall'Acqua
mesh_terms: D001792:Blood Platelets / Q000201:enzymology; D005363:Ficusin / Q000528:radiation effects*; D006801:Humans; D007536:Isomerism; D008968:Molecular Conformation; D015394:Molecular Structure; D019301:Oleic Acid / Q000528:radiation effects*; D010741:Phospholipases A / Q000378:metabolism; D054467:Phospholipases A2; D011493:Protein Kinase C / Q000097:blood*; D013237:Stereoisomerism; D014466:Ultraviolet Rays
chemical_list: D019301:Oleic Acid; D011493:Protein Kinase C; D010741:Phospholipases A; D054467:Phospholipases A2; D005363:Ficusin