title: Increased excitability of the human corticospinal system with hyperventilation.
abstract: OBJECTIVE
  Hyperventilation is effective in inducing generalized spike-wave discharges in patients with absence seizures and improves visual function and normalizes visual function in patients with multiple sclerosis. Hyperventilation increases the excitability of cutaneous and motor axons. In experimental animals, hyperventilation increases excitability of hippocampal neurons. There is however no direct evidence of a hyperventilation-induced increase in neuronal excitability within the central nervous system in humans. In this study we determined the effects of hyperventilation on the human corticospinal system.
  
  
  METHODS
  We studied the effects of hyperventilation on (1) motor evoked potentials (MEPs) induced by transcranial magnetic pulse stimulation of the motor cortex and (2) F-wave responses. Six subjects were studied.
  
  
  RESULTS
  Hyperventilation resulting in an end-tidal pCO2 of 15 mm Hg or less enhanced the amplitude of the MEP and resulted in a shortened onset latency. F-wave amplitudes were enhanced without any change in onset latency.
  
  
  CONCLUSIONS
  These findings indicate that hyperventilation increases the excitability of the human corticospinal system. A hyperventilation-induced increase in excitability within the central nervous system may account for clinical phenomena such as facilitation of spike-wave discharges.
authors.affiliation: Department of Neurology, University of California, Davis Medical Center, Sacramento 95817, USA.
authors.forename: M
authors.initials: M
authors.lastname: Seyal
authors.forename: B
authors.initials: B
authors.lastname: Mull
authors.forename: B
authors.initials: B
authors.lastname: Gage
mesh_terms: D000328:Adult; D001921:Brain / Q000502:physiology; D002540:Cerebral Cortex / Q000503:physiopathology*; D004558:Electric Stimulation; D019054:Evoked Potentials, Motor / Q000502:physiology; D006801:Humans; D006985:Hyperventilation / Q000503:physiopathology*; D008875:Middle Aged; D013116:Spinal Cord / Q000503:physiopathology*