title: Elite endurance athletes and the ACE I allele--the role of genes in athletic performance.
abstract: Genetic markers that might contribute to the making of an elite athlete have not been identified. Potential candidate genes might be found in the renin-angiotensin pathway, which plays a key role in the regulation of both cardiac and vascular physiology. In this study, DNA polymorphisms derived from the angiotensin converting enzyme (ACE), the angiotensin type 1 receptor (AT1) and the angiotensin type 2 receptor (AT2) were studied in 64 Australian national rowers. Compared with a normal population, the rowers had an excess of the ACE I allele (P<0.02) and the ACE II genotype (P=0.03). The ACE I allele is a genetic marker that might be associated with athletic excellence. It is proposed that the underlying mechanism relates to a healthier cardiovascular system.
authors.affiliation: Department of Molecular & Clinical Genetics, Royal Prince Alfred Hospital, Camperdown NSW, Australia.
authors.forename: G
authors.initials: G
authors.lastname: Gayagay
authors.forename: B
authors.initials: B
authors.lastname: Yu
authors.forename: B
authors.initials: B
authors.lastname: Hambly
authors.forename: T
authors.initials: T
authors.lastname: Boston
authors.forename: A
authors.initials: A
authors.lastname: Hahn
authors.forename: D S
authors.initials: DS
authors.lastname: Celermajer
authors.forename: R J
authors.initials: RJ
authors.lastname: Trent
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D010807:Physical Endurance / Q000235:genetics*; D011110:Polymorphism, Genetic; D044140:Receptor, Angiotensin, Type 1; D044139:Receptor, Angiotensin, Type 2; D011945:Receptors, Angiotensin / Q000235:genetics; D012016:Reference Values; D013177:Sports / Q000502:physiology*
chemical_list: D044140:Receptor, Angiotensin, Type 1; D044139:Receptor, Angiotensin, Type 2; D011945:Receptors, Angiotensin; D007703:Peptidyl-Dipeptidase A