-The effect of ondansetron on intracranial pressure and cerebral perfusion pressure in neurosurgical patients-.
OBJECTIVE
To determine the effect of ondansetron on intracranial pressure (ICP), mean arterial pressure (MAP) and cerebral perfusion pressure (CPP).


METHODS
Prospective, comparative, randomized double-blind study.


METHODS
Twenty-six patients undergoing intracranial surgery.


METHODS
Induction was obtained with propofol (1-2.5 mg.kg-1), fentanyl (1.5 micrograms.kg-1) and pancuronium (0.1 mg.kg-1), and maintenance was achieved with propofol and fentanyl. Intermittent positive pressure ventilation was used to ensure mild hypocapnia at 35 +/- 2 mmHg. Positioning of the patient was followed by 15 minutes steady-state. Patient received thereafter either 8 mg ondansetron or a placebo intravenously. The ICP was measured using a lumbar malleable spinal needle. CPP was calculated using the formula CCP = MAP-ICP. All variables were measured every minute for 15 minutes.


RESULTS
The ICP, MAP and CPP did not differ between the two groups. There were no differences in the highest ICP values in patients receiving either ondansetron or placebo (11 +/- 5 versus 9 +/- 5, mean +/- SD), respectively.


CONCLUSIONS
Intravenous administration of 8 mg ondansetron affects neither cerebral hemodynamics nor ICP.
Jacot
A
A
Service d'anesthésiologie, CHU Vaudois, Lausanne, Suisse.
Bissonnette
B
B
Favre
J B
JB
Ravussin
P
P
D000293:Adolescent; D000328:Adult; D000368:Aged; D018686:Anesthetics, Intravenous / Q000008:administration & dosage; D000932:Antiemetics / Q000008:administration & dosage / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D001921:Brain / Q000601:surgery*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004311:Double-Blind Method; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage; D005746:Gastric Emptying / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D007385:Intermittent Positive-Pressure Ventilation; D007427:Intracranial Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D017294:Ondansetron / Q000008:administration & dosage / Q000627:therapeutic use*; D010919:Placebos; D015742:Propofol / Q000008:administration & dosage; D011446:Prospective Studies
D018686:Anesthetics, Intravenous; D000932:Antiemetics; D010919:Placebos; D017294:Ondansetron; D005283:Fentanyl; D015742:Propofol