Oxygen uptake during peritoneal ventilation in a porcine model of hypoxemia.
OBJECTIVE
Peritoneal ventilation (PV) can greatly increase PaO2 in hypoxemic rabbits. We tested the hypothesis that the peritoneum can provide a gas exchange surface for oxygen uptake in larger animals that, like humans, have a smaller relative peritoneal surface area and corresponding blood flow.


METHODS
Prospective, randomized, controlled animal study.


METHODS
University research laboratory.


METHODS
In six anesthetized pigs, a modified endotracheal tube (9.0-inner diameter) was inserted into the peritoneal cavity, and the peritoneal cavity was ventilated with oxygen in helium in gas phase. Measurements of peritoneal oxygen uptake and mixed venous oxygen saturation were made over 30 mins of: a) baseline FiO2 0.20, no PV; b) FiO2 0.20, PV; c) FiO2 0.20, PV, dopamine 5 microg/kg/min; d) baseline FiO2 0.15, no PV; e) FiO2 0.15, PV; and f) FiO2 0.15, PV, dopamine 5 microg/kg/min.


RESULTS
Mixed venous oxygen saturation was 61% at the baseline FiO2 of 0.20 and 33% at an FiO2 of 0.15 and did not increase significantly from baseline with PV or with dopamine at either FiO2. Peritoneal oxygen uptake, measured with a waterseal spirometer, was 9.1+/-3.1 (SD) and 11.9+/-3.0 mL/min when lung FiO2 was 0.20 and 0.15, respectively, and 9.7+/-2.8 and 12.2+/-2.7 mL/min when FiO2 was 0.20 and 0.15 and dopamine was infused, respectively.


CONCLUSIONS
Peritoneal ventilation does not result in clinically significant oxygen uptake or alter mixed venous oxygen saturation in a porcine model of hypoxemia.
Giffin
D M
DM
Department of Anesthesia, St. Paul's Hospital and the University of British Columbia, Vancouver, Canada.
Gow
K W
KW
Warriner
C B
CB
Walley
K R
KR
Phang
P T
PT
D000818:Animals; D004195:Disease Models, Animal; D006439:Hemodynamics; D000860:Hypoxia / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption; D010537:Peritoneum; D011446:Prospective Studies; D011897:Random Allocation; D012121:Respiration, Artificial / Q000379:methods; D013552:Swine
D010100:Oxygen