Expression of group II phospholipase A2 in Paneth cells of an adenoma of the rectum. A case report.
A case of tubulovillous adenoma in the rectum of a 51-year-old man is presented. The tumour contained numerous Paneth cells which formed well-developed glands in the basal areas. Group II phospholipase A2 and lysozyme were found in the tumour cells by immunohistochemistry. mRNA of group II phospholipase A2 was localized in the tumour cells by in situ hybridization. It was concluded that a considerable part of this rare type of tumour consisted of Paneth cells which were capable of synthesizing group II phospholipase A2.
Nevalainen
T J
TJ
Department of Pathology, University of Turku, Finland.
Haapanen
T J
TJ
Rajala
P
P
Ekfors
T
T
D018253:Adenoma, Villous / Q000201:enzymology* / Q000473:pathology; D054501:Group II Phospholipases A2; D006801:Humans; D008297:Male; D008875:Middle Aged; D019879:Paneth Cells / Q000201:enzymology* / Q000473:pathology*; D010741:Phospholipases A / Q000032:analysis*; D054467:Phospholipases A2; D012004:Rectal Neoplasms / Q000201:enzymology* / Q000473:pathology
D010741:Phospholipases A; D054501:Group II Phospholipases A2; D054467:Phospholipases A2