title: [Architecture of compact three alpha-helical structures].
abstract: Modeling and methodical analysis of possible compact spatial arrangements of three alpha helices bound with connections were carried out. It was suggested to describe the compact three-alpha-helical structures as combinations of alpha-helical hairpins, L-shaped structures, V-shaped structures, alpha-alpha comers, and alpha-l-alpha motifs. Practically all the structures resulting from such a modeling were shown to exist in globular proteins. Many small proteins and domains were found to consist of only these three-helical structures. This indicated that each such three-helical structure was stable by itself and capable of independent folding of its polypeptide chain into this structure.
authors.affiliation: Institute of Protein Research, Russian Academy of Sciences, Pushchino, Russia. efimov@ipr.serpukhov.su
authors.forename: A V
authors.initials: AV
authors.lastname: Efimov
mesh_terms: D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry*; D017510:Protein Folding; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry*
chemical_list: D010455:Peptides; D011506:Proteins