Antibacterials and antimycotics: Part 1: Synthesis and activity of 2-pyrazoline derivatives.
A series of 3-styryl-1,5-diphenyl and 5-styryl-1,3-diphenyl 2-pyrazolines of different substitutions has been synthesized by condensation of substituted alpha,beta-unsaturated ketones with phenylhydrazine hydrochloride in presence of catalytic amount of concentrated HCl. Compounds in the 3-styryl series had OMe, NMe2, NO2, OH and isopropyl substituents and those in the 5-styryl series had OMe, NMe2 and NOs. The 3-styryl-1,5-diphenyl compounds showed little variation in antibacterial activity towards gram-positive and gram-negative bacteria in terms of geometric mean minimum inhibitory concentrations (MIC). The 4',4"-NMe2, 4',4"-NO2 and 4',4"-OMe compounds were found to possess the highest activity in the series. The 5-styryl-1,3-diphenyl series showed lower activities than the 3-styryl series. The in vitro antimycotic activity of the 4',4"-OH and 2',2"-OH substituted compounds showed good activity than the other molecules in the two series.
Nauduri
D
D
Department of Organic Chemistry, Andhra University, Visakhapatnam, India.
Reddy
G B
GB
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D011720:Pyrazoles