Acute pancreatitis following lisinopril rechallenge.
Acute pancreatitis has many causes, the most common being biliary tract disease and alcoholism. Other etiologic categories are abdominal trauma; postoperative, including endoscopic retrograde cholangiopancreatography; metabolic, including hypercalcemia and hypertriglyceridemia; Infectious; idiopathic; and drug-induced. The drugs most strongly associated with pancreatitis are sulfonamides, thiazides, furosemide, estrogens, and tetracycline. Approximately 100 cases of pancreatitis induced by angiotensin-converting enzyme inhibitor have been reported to the US Food and Drug Administration, of which about 20 involved lisinopril. We report a case of pancreatitis occurring only 3 hours after intake of lisinopril by a man without other risk factors for the illness. The patient had experienced a similar but less severe reaction to this medication 3 months earlier. This case probably represents the first time a patient was rechallenged with lisinopril and had a more significant adverse reaction.
Gershon
T
T
Emergency Care Services, Veterans Affairs Medical Center, Baltimore, MD 21201, USA.
Olshaker
J S
JS
D000208:Acute Disease; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D000959:Antihypertensive Agents / Q000009:adverse effects*; D004638:Emergency Treatment; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D017706:Lisinopril / Q000009:adverse effects*; D008297:Male; D010195:Pancreatitis / Q000139:chemically induced*
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D017706:Lisinopril