Peritoneal fluid concentrations of interleukin-8 in women with endometriosis: relationship to stage of disease.
There is increasing evidence that immunological mechanisms play a role in the pathogenesis and pathophysiology of endometriosis. It was therefore of interest to study interleukin-8 (IL-8), a chemokine, in the peritoneal fluid and peripheral blood of women undergoing laparoscopic procedures. The presence and concentrations of IL-8 in relation to endometriosis, infertility and abdominal pain were evaluated. Samples of peritoneal fluid (n = 49) and peripheral blood (n = 50) were obtained from 50 consecutive patients undergoing laparoscopic surgery for various gynaecological indications (abdominal pain, infertility, sterilization). IL-8 was present in the peritoneal fluid of most women (87%). The concentration of IL-8 in the peritoneal fluid was higher in women with endometriosis compared to women without (P = 0.02). This difference was more pronounced in early (stage 1) endometriosis (P = 0.001). IL-8 concentrations in the peritoneal fluid were also higher in women with early endometriosis compared to women with later stages of the disease (P = 0.003). Peripheral blood concentrations did not correlate with peritoneal fluid concentrations of IL-8 and/or the presence of endometriosis. We conclude that IL-8 is an important factor that may contribute to the pathogenesis of endometriosis possibly by promoting neovascularization. This information can be a guide in the development of new therapeutic approaches for the treatment of endometriosis.
Gazvani
M R
MR
Liverpool Women's Hospital, UK.
Christmas
S
S
Quenby
S
S
Kirwan
J
J
Johnson
P M
PM
Kingsland
C R
CR
D015746:Abdominal Pain; D000328:Adult; D001202:Ascitic Fluid / Q000737:chemistry*; D004715:Endometriosis / Q000150:complications / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D005498:Follicular Phase; D006801:Humans; D007247:Infertility, Female / Q000209:etiology; D016209:Interleukin-8 / Q000032:analysis* / Q000097:blood; D010535:Laparoscopy; D008183:Luteal Phase; D008597:Menstrual Cycle
D016209:Interleukin-8