title: Comparative histopathology in mouse typhoid among genetically diverse mice.
abstract: Genetically resistant CBA and A/J mice and susceptible BALB/c and C57BL/6 mice were challenged with either an identical infective dose or a minimal lethal dose of Salmonella typhimurium. The histopathological progression of the disease was examined in tissue sections prepared by the JB-4 Plus resin embedding method and compared between the resistant and susceptible mice. In a fatal disease, the lesions in both animal hosts began with focal abscesses within the first three days post infection. Mononuclear cell infiltration started by day 4 and transformed the lesions into granulomata. Well-formed granulomata were evident by day 7 and persisted in sublethally infected resistant mice. Massive bacterial proliferation and extensive tissue degeneration marked the terminal stage of a lethal challenge. There were no distinguishable features that would identify the tissue response to infection in a resistant host from a susceptible one, except that the lesions in the sublethally infected resistant mice advanced slower and were discrete and self-limiting.
authors.affiliation: Department of Microbiology and Immunology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0678, USA.
authors.forename: C W
authors.initials: CW
authors.lastname: Moncure
authors.forename: Y N
authors.initials: YN
authors.lastname: Guo
authors.forename: H R
authors.initials: HR
authors.lastname: Xu
authors.forename: H S
authors.initials: HS
authors.lastname: Hsu
mesh_terms: D000818:Animals; D002455:Cell Division; D018450:Disease Progression; D004198:Disease Susceptibility; D008099:Liver / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D012481:Salmonella Infections, Animal / Q000235:genetics / Q000382:microbiology / Q000473:pathology*; D012486:Salmonella typhimurium; D013045:Species Specificity