Inhalation delivery systems with compliance and disease management capabilities.
Non-compliance with prescribed medication is a major reason for poor therapeutic outcomes, leading to unnecessary contributions to healthcare costs. Poor technique in self-administration of inhalation therapy is a special type of non-compliance associated with this route of administration. However, pulmonary drug delivery has fundamental advantages for therapy of diseases of the respiratory tract because it is site-directed. The lung is also a promising portal for drug delivery into the systemic circulation. Incorporation of microprocessors into pulmonary drug delivery systems facilitates sophisticated compliance management of chronic diseases such as asthma and diabetes. Microprocessor-assisted systems afford control of patients' administration technique during the therapeutic inhalation event, thus leading to efficient and reproducible regional deposition of the inhaled drug or diagnostic agent. SmartMist is a hand-held asthma disease management device that aids patients to use optimally metered dose inhalers. It also measures pulmonary lung function and provides a long term downloadable electronic record of the therapeutic and diagnostic events. The AERx pulmonary delivery system utilizes similar microprocessor capabilities; however, it employs a novel means of generating aqueous aerosols from unit dose packages, thus providing a broad inhalation technology base for delivery of a wide variety of therapeutic and diagnostic agents into the respiratory tract, and via the lung into the systemic circulation.
Gonda
I
I
Aradigm Corporation, Hayward, CA 94545, USA. IgorGonda@aol.com
Schuster
J A
JA
Rubsamen
R M
RM
Lloyd
P
P
Cipolla
D
D
Farr
S J
SJ
D000280:Administration, Inhalation; D000818:Animals; D001249:Asthma / Q000188:drug therapy*; D019468:Disease Management; D006801:Humans; D007328:Insulin / Q000008:administration & dosage; D008173:Lung Diseases, Obstructive / Q000188:drug therapy*; D008252:Macaca fascicularis; D008954:Models, Biological; D015609:Organotechnetium Compounds; D010349:Patient Compliance; D004369:Pentetic Acid; D011877:Radionuclide Imaging; D014018:Tissue Distribution
D007328:Insulin; D015609:Organotechnetium Compounds; D004369:Pentetic Acid