title: Investigation of lipid peroxidation in liposomes induced by heavy ion irradiation.
abstract: Lipid peroxidation induced by heavy ion irradiation was investigated in 1,2-dilinoleoyl-sn-glycero-3-phosphocholine (DLPC) liposomes. Lipid peroxidation was induced using accelerated heavy ions that exhibit linear energy transfer (LET) values between 30 and 15000 keV/microm and doses up to 100 kGy. With increasing LET, the formation of lipid peroxidation products such as conjugated dienes, lipid hydroperoxides, and thiobarbituric acid-reactive substances decreased. When comparing differential absorption spectra and membrane fluidity following irradiation with heavy ions and x-rays (3 Gy/min), respectively, it is obvious that there are significant differences between the influences of densely and sparsely ionizing radiation on liposomal membranes. Indications for lipid fragmentation could be detected after heavy ion irradiation.
authors.affiliation: Experimentalphysik III, Fachbereich 18, Gesamthochschule Kassel, Germany. ziegler@ipno.in2p3.fr
authors.forename: C
authors.initials: C
authors.lastname: Ziegler
authors.forename: J M
authors.initials: JM
authors.lastname: Wessels
mesh_terms: D001128:Argon / Q000009:adverse effects; D004578:Electron Spin Resonance Spectroscopy; D020450:Heavy Ions / Q000009:adverse effects*; D006371:Helium / Q000009:adverse effects; D018499:Linear Energy Transfer; D015227:Lipid Peroxidation / Q000528:radiation effects*; D008081:Liposomes / Q000378:metabolism / Q000528:radiation effects*; D008560:Membrane Fluidity / Q000528:radiation effects; D019216:Metals, Heavy / Q000378:metabolism*; D010713:Phosphatidylcholines / Q000378:metabolism; D014501:Uranium / Q000009:adverse effects; D014965:X-Rays
chemical_list: D008081:Liposomes; D019216:Metals, Heavy; D010713:Phosphatidylcholines; C015153:1,2-dilauroylphosphatidylcholine; D006371:Helium; D014501:Uranium; D001128:Argon