title: [Graft rejection in experimental xenogenic transplantation of isolated islands of Langerhans of the pig].
abstract: Prevention of the occurrence of diabetes-specific vascular complications is the final aim of clinical islet transplantation. Pancreatic islets isolated from adult pigs may be a suitable tissue source to transplant a large number of type 1 diabetic patients. Acute cellular rejection may be finally overcome by clinically applicable protocols for tolerance induction. However, primary nonfunction of the graft, as regularly observed in the porcine islet-to-rat xenotransplantation model, may be an additional problem. In this paper, species-specific inflammatory and immunological mechanisms are discussed which prevent early porcine islet graft function in rats but not in mice.
authors.affiliation: Medizinische Klinik III und Poliklinik, Justus-Liebig-Universität Giessen.
authors.forename: H
authors.initials: H
authors.lastname: Jahr
authors.forename: D
authors.initials: D
authors.lastname: Brandhorst
authors.forename: H
authors.initials: H
authors.lastname: Brandhorst
authors.forename: M
authors.initials: M
authors.lastname: Brendel
authors.forename: T
authors.initials: T
authors.lastname: Eckhardt
authors.forename: A
authors.initials: A
authors.lastname: el-Ouaghlidi
authors.forename: B
authors.initials: B
authors.lastname: Hussmann
authors.forename: D
authors.initials: D
authors.lastname: Lau
authors.forename: F
authors.initials: F
authors.lastname: Nahidi
authors.forename: T
authors.initials: T
authors.lastname: Wacker
authors.forename: A
authors.initials: A
authors.lastname: Zwolinski
authors.forename: R G
authors.initials: RG
authors.lastname: Bretzel
mesh_terms: D000328:Adult; D000818:Animals; D003167:Complement Activation / Q000276:immunology; D016332:Fetal Tissue Transplantation / Q000276:immunology; D006084:Graft Rejection / Q000276:immunology*; D006801:Humans; D016381:Islets of Langerhans Transplantation / Q000276:immunology*; D051379:Mice; D008819:Mice, Nude; D051381:Rats; D013045:Species Specificity; D013552:Swine; D014183:Transplantation, Heterologous / Q000276:immunology*