Evidence that an HLA-DQA1-DQB1 haplotype influences susceptibility to childhood common acute lymphoblastic leukaemia in boys provides further support for an infection-related aetiology.
Comparison of DQA1 and DQB1 alleles in 60 children with common acute lymphoblastic leukaemia (c-ALL) and 78 newborn infant control subjects revealed that male but not female patients had a higher frequency of DQA1*0101/*0104 and DQB1*0501 than appropriate control subjects. The results suggest a male-associated susceptibility haplotype in c-ALL and supports an infectious aetiology.
Taylor
G M
GM
Immunogenetics Laboratory, St Mary's Hospital, Manchester, UK.
Dearden
S
S
Payne
N
N
Ayres
M
M
Gokhale
D A
DA
Birch
J M
JM
Blair
V
V
Stevens
R F
RF
Will
A M
AM
Eden
O B
OB
D000483:Alleles; D017951:Antigen Presentation; D002648:Child; D002675:Child, Preschool; D003141:Communicable Diseases / Q000276:immunology; D004247:DNA / Q000032:analysis; D004198:Disease Susceptibility / Q000276:immunology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006683:HLA-DQ Antigens / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; D006239:Haplotypes; D006801:Humans; D007223:Infant; D008297:Male; D018807:Polymorphism, Single-Stranded Conformational; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000276:immunology; D012737:Sex Factors
D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; C069050:HLA-DQA1 antigen; C069051:HLA-DQB1 antigen; D004247:DNA