Synovial chondromatosis: clonal chromosome changes provide further evidence for a neoplastic disorder.
Synovial chondromatosis is a rare lesion, which is still believed by most authors to be reactive rather than neoplastic. We report on a case of synovial chondromatosis with clonal chromosomal changes [43,XX,der (1) t (1;13) (p21-22;q21),-6,-13,-14, add(21) (q21)]. The presence of clonal chromosomal changes in this and in three previously reported cases suggests that synovial chondromatosis is a true neoplastic lesion.
Sciot
R
R
Department of Pathology, University of Leuven, Belgium.
Dal Cin
P
P
Bellemans
J
J
Samson
I
I
Van den Berghe
H
H
Van Damme
B
B
D000328:Adult; D015838:Chondromatosis, Synovial / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1; D002882:Chromosomes, Human, Pair 13; D002883:Chromosomes, Human, Pair 14; D002891:Chromosomes, Human, Pair 21; D002896:Chromosomes, Human, Pair 6; D005260:Female; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D009369:Neoplasms / Q000235:genetics*; D014178:Translocation, Genetic