Basonuclin, a zinc finger protein associated with epithelial expansion and proliferation.
Basonuclin is a zinc finger protein first described as a keratinoycte specific protein present in various stratified squamous epithelia found in epidermis, esophagis, cornea and virgina. Recent studies showed that its distribution also includes the germ cells of testis and ovary. The presence of basonuclin appeared always related to the cellular proliferative ability not just cell division, for it was found both in dividing and quiescent cells. Basonuclin disappeared when a cell became post-mitotic. This review examines the latest findings about the distribution, molecular and cellular biology of basonuclin and discusses its possible role in cell proliferation.
Tseng
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Department of Dermatology and Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
D000818:Animals; D002455:Cell Division; D002467:Cell Nucleus / Q000378:metabolism; D004268:DNA-Binding Proteins; D004847:Epithelial Cells; D005786:Gene Expression Regulation; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism; D008297:Male; D051379:Mice; D009124:Muscle Proteins / Q000235:genetics; D051787:Myogenic Regulatory Factor 5; D010750:Phosphoproteins; D011506:Proteins / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D012694:Serine / Q000235:genetics; D012867:Skin / Q000378:metabolism*; D013737:Testis / Q000378:metabolism*; D014018:Tissue Distribution; D015534:Trans-Activators; D014157:Transcription Factors; D016335:Zinc Fingers / Q000235:genetics
C511595:Bnc1 protein, mouse; D004268:DNA-Binding Proteins; C497417:MYF5 protein, human; D009124:Muscle Proteins; C497418:Myf5 protein, mouse; D051787:Myogenic Regulatory Factor 5; D010750:Phosphoproteins; D011506:Proteins; D015534:Trans-Activators; D014157:Transcription Factors; C077914:BNC1 protein, human; D012694:Serine