Delivery outcome after the use of acid-suppressing drugs in early pregnancy with special reference to omeprazole.
OBJECTIVE
To study delivery outcome after maternal use of acid-suppressing drugs during early pregnancy.


METHODS
Cohort study of women identified by interview in early pregnancy.


METHODS
Sweden women giving birth from 1995 to early 1997.


METHODS
Comparison of infants exposed to acid-suppressing drugs with all births in 1995-1996.


METHODS
Presence of congenital malformations.


RESULTS
Proton pump blockers were used by 275 women, H2 receptor antagonists by 255 women, and both categories of drugs by 20 women. No effect of the use of omeprazole or H2-receptor antagonists on the rate of congenital malformations could be demonstrated.


CONCLUSIONS
Though a teratogenic effect of these drugs cannot be completely ruled out, the individual risk after exposures during the first trimester seems to be negligible.
Källén
B
B
Tornblad Institute, University of Lund, Sweden.
D000014:Abnormalities, Drug-Induced / Q000453:epidemiology / Q000209:etiology*; D000293:Adolescent; D000328:Adult; D000897:Anti-Ulcer Agents / Q000009:adverse effects*; D015331:Cohort Studies; D005260:Female; D006635:Histamine H2 Antagonists / Q000009:adverse effects; D006801:Humans; D008423:Maternal Age; D008875:Middle Aged; D009853:Omeprazole / Q000009:adverse effects*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D054328:Proton Pump Inhibitors; D013548:Sweden / Q000453:epidemiology
D000897:Anti-Ulcer Agents; D006635:Histamine H2 Antagonists; D054328:Proton Pump Inhibitors; D009853:Omeprazole