[Acquired, cystic kidney disease in chronic dialysis patients: a retrospective study of 125 autopsies. 1: Cysts].
In acquired cystic kidney disease cysts develop in kidneys with impaired excretory function. Bleeding, cyst infection and a possible relation to kidney cell carcinoma resulted in an interdisciplinary concern about this disease. Kidney tissue slides from 125 autopsies of dialysis patients were studied. Of totally 967 cysts, 52% were lined by a cuboidal epithelium, with either clear or eosinophilic cytoplasm; 34% showed a flat epithelium. Multilayered epithelium was present in 8.3% and bleeding stigmata in 5.3%. Cyst counts rose with duration of dialysis, with a higher average cyst count in men. There was no correlation between cysts and (1) age, at the time of death of at the beginning of dialysis, (2) type of renal disease, (3) blood group, (4) body weight, (5) coronary heart disease, and (6) diabetes mellitus. More studies on the development of cysts, parameters of cyst formation and complications are necessary, as they are the basis for the interpretation of new imaging techniques, as well as, for a clinical risk assessment.
Segerer
S
S
Medizinische Poliklinik der LMU, München.
Meister
P
P
D000818:Animals; D004848:Epithelium / Q000473:pathology; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D007668:Kidney / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000473:pathology*; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D007690:Polycystic Kidney Diseases / Q000473:pathology*; D006435:Renal Dialysis