title: N-terminal myosin-binding fragment of talin.
abstract: Talin, an actin-binding protein from smooth muscle, is shown to bind to myosin in such a way that it stimulates the ATPase activity of myosin irrespective of the phosphorylation state of myosin. The binding site is shown to be localized at the N-terminal, 47 KDa fragment. The position of the actin-binding site at the C terminal suggests that talin may work as a crosslinker between myosin and actin.
authors.affiliation: Department of Pharmacology, Gunma University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Lin
authors.forename: H
authors.initials: H
authors.lastname: Kishi
authors.forename: A
authors.initials: A
authors.lastname: Nakamura
authors.forename: T
authors.initials: T
authors.lastname: Takagi
authors.forename: K
authors.initials: K
authors.lastname: Kohama
mesh_terms: D000199:Actins / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D002645:Chickens; D003432:Cross-Linking Reagents; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009130:Muscle, Smooth / Q000378:metabolism; D009218:Myosins / Q000737:chemistry / Q000378:metabolism*; D010446:Peptide Fragments / Q000737:chemistry* / Q000378:metabolism*; D010766:Phosphorylation; D011485:Protein Binding; D016608:Talin / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D000199:Actins; D003432:Cross-Linking Reagents; D010446:Peptide Fragments; D016608:Talin; D009218:Myosins