title: Evidence of profiled hemodialysis efficacy in the treatment of intradialytic hypotension.
abstract: In the last 10 years the percentage of dialysis patients suffering from clinical intradialytic intolerance has greatly increased. Profiled hemodialysis (PHD) is a new technical approach, alternative to standard hemodialysis (SHD) for the treatment of intradialytic symptomatic hypotension. It is based on intradialytic modulation of the dialysate sodium concentration, using a dialysate sodium concentration profile elaborated by a new mathematical kinetic model. The aim of PHD is to reduce the intradialytic blood volume decrease, thanks to a dialysate sodium profile, which allows a reduction in the plasma osmolarity decrease, thereby boosting intravascular fluid refilling. This work aims at clinically validating the PHD technique, by testing its ability against SHD, to maintain a more stable intradialytic blood volume; this evaluation was supported by monitoring some hemodynamic parameters. Twelve dialysis patients on SHD treatment were selected because of their intradialytic symptomatic hypotension. Twelve SHD (one per patient) and 12 PHD sessions (one per patient) were performed to achieve the same sodium mass removal and body weight decrease on both PHD and SHD. During these sessions we monitored the blood volume variation % by the crit-line (a non invasive blood volume monitoring device), the mean blood pressure and heart rate directly and, finally, the stroke volume and cardiac output indirectly by bidimensional doppler-echocardiography. Comparison of the results obtained with the two techniques shows PHD to achieve a significantly more stable blood volume, blood pressure and cardiovascular function than SHD, in particular during the second and the third hour of the dialysis session.
authors.affiliation: Department of Clinical Medicine and Applied Biotechnology, St. Orsola University Hospital, Bologna, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Coli
authors.forename: G
authors.initials: G
authors.lastname: La Manna
authors.forename: V
authors.initials: V
authors.lastname: Dalmastri
authors.forename: A
authors.initials: A
authors.lastname: De Pascalis
authors.forename: G
authors.initials: G
authors.lastname: Pace
authors.forename: G
authors.initials: G
authors.lastname: Santese
authors.forename: C
authors.initials: C
authors.lastname: Stefanio
authors.forename: M
authors.initials: M
authors.lastname: Ursino
authors.forename: F
authors.initials: F
authors.lastname: Zacà
authors.forename: S
authors.initials: S
authors.lastname: Stefoni
mesh_terms: D000368:Aged; D001794:Blood Pressure; D001810:Blood Volume; D002302:Cardiac Output / Q000502:physiology; D018592:Cross-Over Studies; D015314:Dialysis Solutions; D015150:Echocardiography, Doppler; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007022:Hypotension / Q000209:etiology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D006435:Renal Dialysis / Q000009:adverse effects / Q000379:methods*; D012964:Sodium / Q000378:metabolism; D013318:Stroke Volume / Q000502:physiology
chemical_list: D015314:Dialysis Solutions; D012964:Sodium