title: Is there a "non-MAO" macromolecular target for L-deprenyl?: Studies on MAOB mutant mice.
abstract: Several irreversible inhibitors of monoamine oxidase B, can promote survival of damaged neurons in several animal models of cerebral injury. Today it is evident that this effect is not a consequence of monoamine inhibition. Instead it has been proposed that L-deprenyl may act via an unrelated non-monoamine oxidase type- of binding site. In the present study we have investigated if brain tissue from MAOB knockout mice contain such "non-MAO" binding sites for radiolabelled deprenyl. Interestingly, no binding of L-deprenyl was observed indicating that the mother compound does not act directly via a macromolecular target. This is enticing since several alternative mechanisms of action have been proposed in the literature.
authors.affiliation: Department of Neuroscience, Uppsala University, Sweden. jonas.ekblom@medfarm.uu.se
authors.forename: J
authors.initials: J
authors.lastname: Ekblom
authors.forename: L
authors.initials: L
authors.lastname: Oreland
authors.forename: K
authors.initials: K
authors.lastname: Chen
authors.forename: J C
authors.initials: JC
authors.lastname: Shih
mesh_terms: D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000378:metabolism; D003720:Densitometry; D051379:Mice; D018345:Mice, Knockout; D008995:Monoamine Oxidase / Q000235:genetics*; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D011955:Receptors, Drug / Q000235:genetics / Q000378:metabolism; D012642:Selegiline / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D008996:Monoamine Oxidase Inhibitors; D011955:Receptors, Drug; D012642:Selegiline; D008995:Monoamine Oxidase