Lateral hypothalamus modulates the intrinsic splenic natural killer cell activity in rats.
Electrical stimulation of the lateral hypothalamus (LH) in rats increased splenic natural killer (NK) cell activity, whereas electrical ablation of the LH decreased it. However, the percentage of NK cells, as detected by the anti-NKR-P1 monoclonal antibody, in the spleen did not change significantly. These results suggest that the LH does not modulate the splenic NK cell activity by increasing the NK cell number but by increasing the intrinsic NK cell activity itself.
Iimori
H
H
Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.
Kawamura
N
N
Wenner
M
M
Murakami
M
M
Yamamoto
H
H
D000818:Animals; D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000032:analysis / Q000276:immunology; D004558:Electric Stimulation; D007026:Hypothalamic Area, Lateral / Q000276:immunology* / Q000502:physiology; D007694:Killer Cells, Natural / Q000276:immunology*; D037181:Lectins, C-Type; D018655:Lymphocyte Count; D008297:Male; D008562:Membrane Glycoproteins / Q000032:analysis / Q000276:immunology; D055651:NK Cell Lectin-Like Receptor Subfamily B; D051381:Rats; D011971:Receptors, Immunologic / Q000032:analysis / Q000276:immunology; D013154:Spleen / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D037181:Lectins, C-Type; D008562:Membrane Glycoproteins; D055651:NK Cell Lectin-Like Receptor Subfamily B; D011971:Receptors, Immunologic