title: The metabolic anatomy of tremor in Parkinson's disease.
abstract: OBJECTIVE
  To identify regional metabolic brain networks related specifically to the presence of tremor in PD.
  
  
  BACKGROUND
  The pathophysiology of parkinsonian tremor is unknown. Because tremor in PD occurs mainly in repose, we used resting state PET with 18F-fluorodeoxyglucose (FDG) to identify specific metabolic brain networks associated with this clinical manifestation.
  
  
  METHODS
  We studied two discrete groups of eight PD patients with and without tremor using FDG/PET. Both patient groups were matched for gender, age, and Unified Parkinson Disease Rating Scale ratings for akinesia and rigidity. Ten normal volunteer subjects served as controls.
  
  
  RESULTS
  Network analysis with the Scaled Subprofile Model was performed in two steps. 1) We computed the expression of the PD-related pattern (PDRP) identified by us previously in each of the PD patients and control subjects. Although PDRP subject scores were abnormally elevated in the combined PD cohort (p < 0.005), these values did not differ in the PD patient groups with and without tremor (p = 0.36). 2) We used SSM to analyze the data from the combined PD cohort comprising both patient groups. We found that PD patients with tremor were characterized by increased expression of a metabolic network comprising the thalamus, pons, and premotor cortical regions. Subject scores for this pattern were elevated in the tremor group compared with the atremulous patient group and the normal control group (p < 0.005).
  
  
  CONCLUSIONS
  The findings suggest that PD patients with tremor are characterized by distinct increases in the functional activity of thalamo-motor cortical projections. Modulation of this functional anatomic pathway is likely to be the mechanism for successful interventions for the relief of parkinsonian tremor.
authors.affiliation: Department of Neurology, North Shore University Hospital, Manhasset, NY 11030, USA.
authors.forename: A
authors.initials: A
authors.lastname: Antonini
authors.forename: J R
authors.initials: JR
authors.lastname: Moeller
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: P
authors.initials: P
authors.lastname: Spetsieris
authors.forename: V
authors.initials: V
authors.lastname: Dhawan
authors.forename: D
authors.initials: D
authors.lastname: Eidelberg
mesh_terms: D000368:Aged; D001921:Brain / Q000378:metabolism; D005260:Female; D005462:Fluorine Radioisotopes; D019298:Glucose-6-Phosphate / Q000031:analogs & derivatives / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000378:metabolism* / Q000503:physiopathology*; D014055:Tomography, Emission-Computed; D014202:Tremor / Q000378:metabolism* / Q000503:physiopathology*
chemical_list: D005462:Fluorine Radioisotopes; C047515:2-fluoro-2-deoxyglucose-6-phosphate; D019298:Glucose-6-Phosphate