title: Effects of cardiopulmonary bypass and deep hypothermic circulatory arrest on the thyroid axis during and after repair of congenital heart defects: preservation by deep hypothermia?
abstract: Thyroid function is altered by cardiopulmonary bypass (CPB) in children. To better understand the cause of altered thyroid hormone levels, we compared the effects on the pituitary-thyroid axis of CPB in 23 children undergoing elective repair of congenital heart defects. Twelve patients underwent CPB with moderate hypothermia without a period of deep hypothermic circulatory arrest (DHCA), and eleven underwent CPB with DHCA. Nine blood samples were collected from each patient before, during, and after CPB. Free T3 (FT3), free T4 (FT4), total T3 (TT3), total T4 (TT4), thyrotropin (TSH), and albumin were measured; concentrations of each decreased significantly with the onset of CPB (P < 0.05). There was a greater decline in hormone than in albumin concentrations, which suggests that factors in addition to hemodilution were present (P < 0.05). TSH concentrations in the DHCA group began to increase during cooling, exceeding baseline values after rewarming and after separation from CPB. Patients undergoing CPB without DHCA had persistently low TSH concentrations (P < 0.05). By Postoperative Days 1 and 2, TSH concentrations in both groups were similar and significantly lower than baseline values (P < 0.001). FT3, FT4, TT3, TT4, and albumin all increased during CPB after an initial decrease. Of these, only albumin and FT4 recovered to their baseline values after the initial decrease. Nevertheless, by Postoperative Day 1, both groups demonstrated the "sick" euthyroid syndrome and could not be distinguished from one another. This study demonstrates greater pituitary release of TSH in children undergoing repair of congenital heart defects with DHCA compared with CPB alone, the cause of which could not be determined in this study. However, despite the increase in TSH in the DHCA group, the thyroid hormone concentrations failed to increase appropriately.
  
  
  CONCLUSIONS
  Early after deep hypothermia circulatory arrest, thyrotopin concentrations increase appropriately, responding to decreased concentrations of T3; however, all children undergoing cardiopulmonary bypass eventually develop a "sick" euthyroid syndrome by Postoperative Day 1. Whether this difference represents better protection of neuroendocrine function by deep hypothermic circulatory arrest (relative to cardiopulmonary bypass alone) remains speculative.
authors.affiliation: Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1009, USA.
authors.forename: D G
authors.initials: DG
authors.lastname: Ririe
authors.forename: J F
authors.initials: JF
authors.lastname: Butterworth
authors.forename: M
authors.initials: M
authors.lastname: Hines
authors.forename: J W
authors.initials: JW
authors.lastname: Hammon
authors.forename: G P
authors.initials: GP
authors.lastname: Zaloga
mesh_terms: D002315:Cardiopulmonary Bypass; D002675:Child, Preschool; D005260:Female; D006324:Heart Arrest, Induced; D006330:Heart Defects, Congenital / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007036:Hypothermia, Induced; D007223:Infant; D008297:Male; D013961:Thyroid Gland / Q000502:physiology*; D013963:Thyroid Hormones / Q000097:blood
chemical_list: D013963:Thyroid Hormones