Cutaneous vascular infarcts secondary to spontaneous platelet aggregation.
We report a 23-year-old woman presenting with multiple cutaneous infarcts who was found to have spontaneous platelet aggregation (SPA). Her skin lesions showed a good response to aspirin therapy and platelet aggregation returned to normal. Subsequently, she was found to have and was treated for pulmonary tuberculosis. The SPA may have been related to this via the formation of immune complexes. Isolated cutaneous infarcts have not previously been described in association with SPA. The role of spontaneous and increased platelet aggregation in skin disorders is discussed.
Lear
J T
JT
Department of Dermatology, Leicester Royal Infirmary, U.K.
Graham
C
C
Pavord
S
S
Mitchell
V
V
Hutchinson
P E
PE
D000328:Adult; D001241:Aspirin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007238:Infarction / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D010974:Platelet Aggregation; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011247:Pregnancy; D012867:Skin / Q000098:blood supply*; D017445:Skin Diseases, Vascular / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D014397:Tuberculosis, Pulmonary / Q000150:complications
D010975:Platelet Aggregation Inhibitors; D001241:Aspirin