Pharmacokinetic study in dogs and monkeys after single intravenous and oral administrations of [14C]-ITF-296.
Pharmacokinetics of [14C]-ITF-296 and its metabolites, ITF-1124 and ITF-1577, were studied in dogs and monkeys after a single intravenous (2.5 mg/kg) and oral (10 mg/kg) administration. Radioactivity was measured by LSC while unchanged drug and its metabolites in plasma were assayed by an HPLC-UV method. The absorption of [14C]-ITF-296 after oral administration is practically complete both in dogs and in monkeys. The determination of unchanged drug and its metabolites shows quite a similar profile in dogs and monkeys for ITF-296 and ITF-1124 and a different time-course for ITF-1577. Elimination of radioactivity occurs mainly in urine (namely 70-80%) for both species and the recovery of the dose (higher than 90%) takes place up to 96 h after both treatments.
Giachetti
C
C
Istituto di Ricerche Biomediche A. Marxer, RBM S.p.A., Colleretto Giacosa (TO), Italy.
Bertolino
M
M
Canali
S
S
Lombardini
E
E
Monzani
M V
MV
Sala
A
A
Zanolo
G
G
D000042:Absorption; D000284:Administration, Oral; D000818:Animals; D048588:Benzoxazines; D002250:Carbon Radioisotopes; D004285:Dogs; D007275:Injections, Intravenous; D007511:Ischemia / Q000517:prevention & control; D008252:Macaca fascicularis; D008297:Male; D009566:Nitrates / Q000097:blood / Q000493:pharmacokinetics*; D010078:Oxazines / Q000097:blood / Q000493:pharmacokinetics*
D048588:Benzoxazines; D002250:Carbon Radioisotopes; D009566:Nitrates; D010078:Oxazines; C091726:sinitrodil