title: Mediastinal germ cell tumor in a child with precocious puberty and Klinefelter syndrome.
abstract: An 8-year-old boy presented with precocious puberty and a mediastinal mass. A computer search showed that this rare presentation is most common with germ cell tumor of the mediastinum in children with Klinefelter syndrome. The tumor was completely resected after preoperative chemotherapy, and the patient is well 2 years after the operation. In patients with Klinefelter syndrome, germ cell tumors are 50 times more common than in patients without Klinefelter syndrome, usually contain nonseminomatous elements, present at an earlier age, and are seldom testicular in location.
authors.affiliation: Department of General and Oncologic Surgery, City of Hope National Medical Center, Duarte, California 91010, USA.
authors.forename: G G
authors.initials: GG
authors.lastname: Bebb
authors.forename: F W
authors.initials: FW
authors.lastname: Grannis
authors.forename: I B
authors.initials: IB
authors.lastname: Paz
authors.forename: M L
authors.initials: ML
authors.lastname: Slovak
authors.forename: R
authors.initials: R
authors.lastname: Chilcote
mesh_terms: D002648:Child; D018237:Germinoma / Q000150:complications* / Q000628:therapy; D006801:Humans; D007713:Klinefelter Syndrome / Q000150:complications*; D008297:Male; D008479:Mediastinal Neoplasms / Q000150:complications* / Q000628:therapy; D011629:Puberty, Precocious / Q000209:etiology*