Erythropoietic protoporphyria treated with narrow-band (TL-01) UVB phototherapy.
Erythropoietic protoporphyria is a rare photodermatosis for which treatment options are limited. The present report describes the clinical features of a patient with erythropoietic protoporphyria and liver function test abnormalities associated with treatment with beta-carotene. Subsequent treatment with narrow-band UVB phototherapy resulted in marked subjective improvement in photosensitivity, which was confirmed by abolition of demonstrated abnormalities on monochromator phototesting. The therapeutic options for photosensitivity in erythropoietic protoporphyria are reviewed and discussed.
Warren
L J
LJ
Dermatology Department, Amersham Hospital, Buckinghamshire, United Kingdom. lvwarren@olis.net.au
George
S
S
D000975:Antioxidants / Q000627:therapeutic use; D016644:Canthaxanthin / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury; D002648:Child; D005243:Feces / Q000737:chemistry; D006801:Humans; D008297:Male; D017121:Porphyria, Hepatoerythropoietic / Q000188:drug therapy / Q000532:radiotherapy*; D011524:Protoporphyrins / Q000032:analysis / Q000097:blood / Q000652:urine; D014466:Ultraviolet Rays / Q000145:classification; D014467:Ultraviolet Therapy; D019207:beta Carotene / Q000009:adverse effects / Q000627:therapeutic use
D000975:Antioxidants; D011524:Protoporphyrins; D019207:beta Carotene; D016644:Canthaxanthin