title: TAP1 polymorphism identified in African-American Graves' disease patients.
abstract: Polymorphism in transporter associated with antigen processing (TAP)1 gene has been observed in African American Graves' disease patients. Single strand conformational polymorphism has been used to identify variation for the locus. First-strand cDNA was generated from cell lines obtained by Epstein-Barr virus immortalization. Four variant alleles for TAP1 have been observed and the products have been sequenced to compare with the location of observed with SSCP position patterns. Variants were detected and compared with substitutions within TAP1 polypeptide which includes changing valine to leucine and three (3) silent substitutions for glycine, glutamic acid and alanine.
authors.affiliation: Department of Biology, College of Arts & Sciences, Delaware State University, Dover 19901, USA.
authors.forename: M H
authors.initials: MH
authors.lastname: Ofosu
authors.forename: C
authors.initials: C
authors.lastname: Brown
authors.forename: W
authors.initials: W
authors.lastname: Cheatham
authors.forename: L
authors.initials: L
authors.lastname: Henry
authors.forename: C
authors.initials: C
authors.lastname: Austin
mesh_terms: D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000328:Adult; D000483:Alleles; D001483:Base Sequence; D044383:Black People / Q000235:genetics*; D004277:DNA, Single-Stranded / Q000032:analysis; D014644:Genetic Variation; D006111:Graves Disease / Q000235:genetics*; D006801:Humans; D008285:Major Histocompatibility Complex; D008875:Middle Aged; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction / Q000379:methods; D018807:Polymorphism, Single-Stranded Conformational; D001741:Black or African American
chemical_list: D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D018528:ATP-Binding Cassette Transporters; D004277:DNA, Single-Stranded; C073119:TAP1 protein, human