Peripheral benzodiazepine receptor expression on leukocytes and neutrophil function during anticonvulsant monotherapy.
Epileptic patients on long-term therapy with a single anticonvulsant showed enhanced expression of peripheral benzodiazepine receptors (pBZrs) on neutrophils, monocytes and lymphocytes. N-Formyl-methionyl-leucyl-phenylalanine-induced chemotaxis was significantly impaired in neutrophils from patients on carbamazepine (p < 0.01 vs. controls). Neutrophils from patients on phenytoin had enhanced phorbol myristate acetate-stimulated O-2 production (p < 0. 01 vs. controls) and neutrophils from patients on valproic acid had impaired phagocytosis frequency and Staphylococcus aureus lethality index (p < 0.01 vs. controls). Overexpression of pBZrs on leukocytes may reflect the clinical response to anticonvulsants and may play a role in the immunological effects of some of these drugs.
Caldiroli
E
E
Department of Internal Medicine and Therapeutics, University of Pavia, Pavia and Varese, Italy.
Marino
F
F
Cosentino
M
M
De Ponti
F
F
Fietta
A M
AM
Mazzone
A
A
Zibetti
A
A
Lecchini
S
S
Frigo
G M
GM
D000293:Adolescent; D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000494:pharmacology / Q000627:therapeutic use*; D002220:Carbamazepine / Q000494:pharmacology / Q000627:therapeutic use; D004827:Epilepsy / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D008214:Lymphocytes / Q000187:drug effects / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D010672:Phenytoin / Q000494:pharmacology / Q000627:therapeutic use; D011963:Receptors, GABA-A / Q000096:biosynthesis* / Q000502:physiology; D014635:Valproic Acid / Q000494:pharmacology / Q000627:therapeutic use
D000927:Anticonvulsants; D011963:Receptors, GABA-A; D002220:Carbamazepine; D014635:Valproic Acid; D010672:Phenytoin