Cellular and subcellular antioxidants involved in liver susceptibility to xenobiotics.
Our previous studies have shown that some important serum erythrocyte and liver antioxidative defense factors--ceruloplasmine, catalase, superoxid dismutase, glutathione -SH and protein-SH groups--were sensitively affected by xenobiotics impact in rat. The data are completed here with the subcellular level of these factors. Dose or time exposure induced appreciable changes of the antioxidative factors (catalase, superoxid dismutase, ceruloplasmine) suggesting their redistribution between the subcellular fractions. The liver morphological investigations in all experimental variants express the aggressivity of Carbofuran administered alone and the "correctional" effects of the modulators' interference.
Codorean
E
E
Victor Babeş, Institute, Bucharest, Romania.
Filipescu
G
G
Ciotaru
L
L
Tănase
C
C
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001241:Aspirin / Q000494:pharmacology; D002110:Caffeine / Q000494:pharmacology; D002235:Carbofuran / Q000633:toxicity*; D002374:Catalase / Q000378:metabolism*; D002570:Ceruloplasmin / Q000378:metabolism; D004492:Edetic Acid / Q000494:pharmacology; D004912:Erythrocytes / Q000201:enzymology; D005978:Glutathione / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism*; D014810:Vitamin E / Q000494:pharmacology
D000975:Antioxidants; D014810:Vitamin E; D002110:Caffeine; D004492:Edetic Acid; D002374:Catalase; D013482:Superoxide Dismutase; D002570:Ceruloplasmin; D005978:Glutathione; D001241:Aspirin; D002235:Carbofuran