Granular cell foci of the uterus in Donryu rats.
Eleven cases of uterine granular cell foci were observed in a total of 855 female Donryu rats. All the lesions were microscopical and focal or multifocal in nature, and composed of uniformly large cells with abundant granulated eosinophilic cytoplasm. Histopathologically, immunohistochemically and ultrastructurally they resembled granular cell tumours of the uterus reported in rats and mice. The development of granular cell foci may be the result of hormonal stimulation.
Sasahara
K
K
Department of Pathology, Sasaki Institute, Tokyo, Japan.
Ando-Lu
J
J
Nishiyama
K
K
Takahashi
M
M
Yoshida
M
M
Maekawa
A
A
D000230:Adenocarcinoma / Q000139:chemically induced / Q000473:pathology; D000818:Animals; D001284:Atrophy / Q000139:chemically induced / Q000473:pathology; D014408:Biomarkers, Tumor / Q000378:metabolism; D002273:Carcinogens / Q000633:toxicity; D004714:Endometrial Hyperplasia / Q000139:chemically induced / Q000473:pathology; D005260:Female; D016586:Granular Cell Tumor / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology*; D007124:Immunoenzyme Techniques; D010053:Ovary / Q000187:drug effects / Q000473:pathology; D010503:Periodic Acid-Schiff Reaction; D051381:Rats; D014594:Uterine Neoplasms / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology*
D014408:Biomarkers, Tumor; D002273:Carcinogens