[Acute generalized exanthematic pustulosis after intake of clozapine (leponex). First case] case].
BACKGROUND
Acute generalized exanthematic pustulosis is a severe adverse drug reaction which occurs after taking antibiotics. Rare cases implicating psychotrops have been observed.


METHODS
A 71-year old women with schizophrenia was given closapine for six weeks when she developed an erythematopustular skin reaction and fever typical of acute generalized exanthematic pustulosis. The skin disease regressed one week after withdrawing clozapine.


CONCLUSIONS
This is the first case of acute generalized exanthematic pustulosis observed after taking the neuroleptic drug, clozapine, used in severe schizophrenia.
Bosonnet
S
S
Service de Dermatologie, CHU de Nîmes.
Dandurand
M
M
Moati
L
L
Guillot
B
B
D000208:Acute Disease; D000368:Aged; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003024:Clozapine / Q000009:adverse effects* / Q000627:therapeutic use; D005076:Exanthema / Q000139:chemically induced*; D005260:Female; D006801:Humans; D012559:Schizophrenia / Q000188:drug therapy; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced*
D014150:Antipsychotic Agents; D003024:Clozapine