HIV infection and AIDS.
The entry of one HIV virion into a human being has the potential to cause death by the inexorable replication of the virus within the principal T lymphocyte, the CD4+ T cell. Although combination antiretroviral therapy, particularly therapy with protease inhibitors, decreases the viral burden to very low, even undetectable, levels, sequestration of the virus in privileged sites, including a long-lived CD4+ T cell, has frustrated efforts at eradication of HIV. Activation of the immune system, therefore, appears essential before this infection can be conquered. Powerful vaccines capable of preventing infection remain the hope of the world.
Shearer
W T
WT
Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
D016915:AIDS Vaccines / Q000627:therapeutic use; D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D019380:Anti-HIV Agents / Q000627:therapeutic use; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D005260:Female; D015658:HIV Infections / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D015497:HIV-1; D006801:Humans; D007167:Immunotherapy; D008297:Male; D019707:Receptors, Chemokine / Q000502:physiology; D019562:Viral Load
D016915:AIDS Vaccines; D019380:Anti-HIV Agents; D019707:Receptors, Chemokine