title: Optimization of beam orientation in radiotherapy using planar geometry.
abstract: This paper proposes a new geometrical formulation of the coplanar beam orientation problem combined with a hybrid multiobjective genetic algorithm. The approach is demonstrated by optimizing the beam orientation in two dimensions, with the objectives being formulated using planar geometry. The traditional formulation of the objectives associated with the organs at risk has been modified to account for the use of complex dose delivery techniques such as beam intensity modulation. The new algorithm attempts to replicate the approach of a treatment planner whilst reducing the amount of computation required. Hybrid genetic search operators have been developed to improve the performance of the genetic algorithm by exploiting problem-specific features. The multiobjective genetic algorithm is formulated around the concept of Pareto optimality which enables the algorithm to search in parallel for different objectives. When the approach is applied without constraining the number of beams, the solution produces an indication of the minimum number of beams required. It is also possible to obtain non-dominated solutions for various numbers of beams, thereby giving the clinicians a choice in terms of the number of beams as well as in the orientation of these beams.
authors.affiliation: Control Theory and Applications Centre, Coventry University, UK. ctac@coventry.ac.uk
authors.forename: O C
authors.initials: OC
authors.lastname: Haas
authors.forename: K J
authors.initials: KJ
authors.lastname: Burnham
authors.forename: J A
authors.initials: JA
authors.lastname: Mills
mesh_terms: D000465:Algorithms; D006801:Humans; D008297:Male; D008433:Mathematics; D019047:Phantoms, Imaging; D011467:Prostate / Q000000981:diagnostic imaging; D011878:Radiotherapy / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D012007:Rectum / Q000000981:diagnostic imaging; D013131:Spine / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed