title: [Lichen planus in children: role of the campaign for hepatitis B vaccination].
abstract: BACKGROUND
  Cutaneous lichen planus in children is a rare entity. To study its specific clinical and therapeutic features, we report on 8 cases seen in 5 years in a pediatric dermatology clinic. In parallel, this study addresses the role of HBV immunization campaigns in childhood lichen planus.
  
  
  METHODS
  Six boys and two girls with a diffuse form of lichen planus were studied. The mean age was 11 years. Four children were of skin types V and VI. Lesions followed Blaschko's lines in two children. One case was associated with atopic dermatitis. In half the cases--the most recent--the eruption was noted after HBV immunization. Biopsy specimens from seven children were reviewed and confirmed the diagnostic of lichen planus. Oral retinoids or corticosteroids were used successfully in six cases.
  
  
  CONCLUSIONS
  Half of our cases confirmed the atypical features of lichen planus in childhood. This study confirms the predominance of lichen planus in children with pigmented skin suggesting a genetic predisposition. The eruption following Blaschko's lines suggests that a clonal keratinocytic population is the target of lichenoid inflammation. HBV immunization could be a stimulus triggering a cytotoxic lymphocyte-mediated reaction. The proportion of affected children was low in comparison with all children immunized. So lichen planus arises probably in predisposed children. This justifies surveillance in the pediatric and dermatologic medical communities.
authors.affiliation: Unité de Dermatologie Pédiatrique, Groupe Hospitalier Pellegrin, Bordeaux.
authors.forename: D
authors.initials: D
authors.lastname: Mérigou
authors.forename: C
authors.initials: C
authors.lastname: Léauté-Labrèze
authors.forename: S
authors.initials: S
authors.lastname: Louvet
authors.forename: P
authors.initials: P
authors.lastname: Bioulac-Sage
authors.forename: A
authors.initials: A
authors.lastname: Taïeb
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004198:Disease Susceptibility; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control*; D017325:Hepatitis B Vaccines / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D008010:Lichen Planus / Q000139:chemically induced*; D008297:Male
chemical_list: D017325:Hepatitis B Vaccines