title: Evaluation of topical formulations of aqueous extract of Centella asiatica on open wounds in rats.
abstract: Formulations (ointment, cream and gel) of aqueous extract of C. asiatica, when applied topically, thrice daily for 24 days on the open wounds in rats increased cellular proliferation and collagen synthesis at the wound site, as evidenced by increase in collagen content and tensile strength. The treated wounds epithelialised faster and the rate of wound contraction was higher as compared to control wounds. The process of healing was better with gel formulation when compared to other two formulations.
authors.affiliation: J.S.S. College of Pharmacy, Mysore, India.
authors.lastname: Sunilkumar
authors.forename: S
authors.initials: S
authors.lastname: Parameshwaraiah
authors.forename: H G
authors.initials: HG
authors.lastname: Shivakumar
mesh_terms: D000287:Administration, Topical; D000818:Animals; D003094:Collagen / Q000378:metabolism; D005260:Female; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D010936:Plant Extracts; D003094:Collagen