The development of new biotechnologies using metalloprotein design.
A variety of methodologies are under development to alter the behavior of existing metal centers or create entirely new sites within a protein framework in order to exploit the intrinsic chemical versatility of metals using the exquisite level of control that a protein matrix can exert to modulate their reactivity. Even at this relatively early stage, engineering of metal centers has led to the development of a number of emerging technologies with a wide variety of applications, including affinity purification of proteins, engineering of metal-mediated protein stability, control of protein activity, imaging and therapy, biosensors, and new catalysts.
Benson
DE
Department of Biochemistry Box 3711 Duke University Medical Center Durham, NC 27710, USA
Wisz
MS
Hellinga
HW