[The transplantation of hemopoietic cells in patients with solid tumors].
OBJECTIVE
Evaluation of efficiency of bone marrow and peripheral stem cells transplantation in patients with solid tumors.


METHODS
A total of 38 patients aged 30-40 years with stage III or IV solid tumors (15 cases of breast cancer, 5 cases of Ewing's sarcoma, 4 cases of osteogenic sarcoma, ovarian or testicular tumors, 3 cases of soft tissue sarcoma) underwent high-dose polychemotherapy with autologous hematopoietic rescue. All the patients were resistant to the first line chemotherapy or were in relapse of the disease. 21, 11 and 6 patients were transplanted bone marrow, peripheral blood stem cells and both bone marrow and peripheral blood stem cells, respectively.


RESULTS
The only factor which influenced overall survival of the patients was the stage of the disease at the moment of the transplantation. 66% of patients in complete or partial remission survived 3 years versus 16.6% of those in progression or relapse of the disease. Other parameters such as the patients' age, the source of hemopoietic cells, number of chemotherapy courses were not essential for the survival. 2 patients died after transplantation. The main cause of death was relapse or progression of the disease after the transplantation.


CONCLUSIONS
Transplantation of hemopoietic cells is a promising therapy of patients with solid tumors sensitive to chemotherapy.
Mikhaĭlova
N B
NB
Darskaia
E I
EI
Morozova
E V
EV
Shavva
S A
SA
Soldatenkov
V E
VE
Katyshev
A V
AV
Orlov
A A
AA
Platonova
G G
GG
Fregatova
L M
LM
Afanas'ev
B V
BV
D000206:Actuarial Analysis; D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000401:mortality / Q000628:therapy*; D012074:Remission Induction