[Hyperexpression of the multiple drug resistance gene (MDR-1) in chronic myeloleukemia patients].
OBJECTIVE
To elucidate prognostic value of MDR-1 gene expression in patients with chronic myeloid leukemia (CML).


METHODS
The MDR-1 gene expression was studied by in situ hybridization in hemopoietic cells of 63 Ph-positive CML patients in different phases of the disease. The survival of the patients and duration of the chronic phase (CP) were evaluated using the Caplan-Meyer method.


RESULTS
MDR-1-positive patients had a shorter survival (p < 0.01) and CP (p < 0.05) than negative ones. MDR-1 gene overexpression has no impact either on the survival or duration of AP and BP (p < 0.05). Moreover, the MDR-1 gene overexpression is not dependent either on the previous treatment or other prognostic markers.


CONCLUSIONS
Overexpression of MDR-1 gene is an independent prognostic factor and an additional parameter to Sokal's scores.
Stiuf
I Iu
IIu
Bykova
T V
TV
Zaritskiĭ
A Iu
AIu
Frolova
O I
OI
Marinets
O V
OV
Afanas'ev
B V
BV
D000293:Adolescent; D000328:Adult; D000368:Aged; D015342:DNA Probes; D005260:Female; D015973:Gene Expression Regulation, Leukemic / Q000235:genetics*; D019450:Genes, MDR / Q000235:genetics*; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016019:Survival Analysis
D015342:DNA Probes