[Treatment of cytomegalovirus retinitis in AIDS with an intraocular sustained-release ganciclovir implant].
Active cytomegalovirus (CMV) retinitis in patients with acquired immunodeficiency syndrome (AIDS) was treated with an intraocular sustained-release ganciclovir implant. A total number of 19 implants were performed in 15 eyes of 9 AIDS patients. The intraocular sustained-release ganciclovir was effective in preventing reactivation of CMV retinitis in 15 of the 19 implants, ineffective in 3, and undetermined in 1. All ineffective cases had been resistant to ganciclovir therapy before the implants. Vision after the therapy was maintained at better than 0.5 except for one eye. There were no serious ocular complications caused by the therapy. Among 5 patients with unilateral CMV retinitis, 2 unaffected eyes developed CMV retinitis during this therapy. In addition, another patient developed presumed CMV infection in other systemic organs. Based on these data, the intraocular sustained-release ganciclovir implant was considered to be useful for the treatment of CMV retinitis in AIDS.
Mochizuki
M
M
Department of Ophthalmology, Kurume University School of Medicine, Fukuoka-ken, Japan.
Ikeda
E
E
Yoshimura
K
K
Hikita
N
N
Nagata
Y
Y
Iwamoto
A
A
Fujino
Y
Y
Eguchi
S
S
Oka
S
S
Kimura
S
S
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy*; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage*; D017726:Cytomegalovirus Retinitis / Q000188:drug therapy*; D003692:Delayed-Action Preparations; D004343:Drug Implants; D015774:Ganciclovir / Q000008:administration & dosage*; D006801:Humans; D007908:Lens, Crystalline; D008297:Male; D008875:Middle Aged
D000998:Antiviral Agents; D003692:Delayed-Action Preparations; D004343:Drug Implants; D015774:Ganciclovir