Prolactin: the forgotten hormone of human breast cancer.
Prolactin (PRL) is both a mitogen and a differentiating agent in the mammary gland. It has been shown to be involved in mammary cancer development in rodents, but in human breast cancer, its role has long been overlooked. Three criteria are applied to demonstrate PRL's involvement in this disease: (1) PRL receptors are present in human breast cancer cells, (2) human breast cancer cells in culture respond to PRL as a mitogen, and (3) PRL is synthesized by human breast cancer cells and inhibition of the binding of PRL to its receptors inhibits cell growth.
Vonderhaar
B K
BK
Molecular and Cellular Endocrinology Section, Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
D000818:Animals; D001943:Breast Neoplasms / Q000097:blood / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008938:Mitosis / Q000502:physiology; D011388:Prolactin / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000097:blood / Q000502:physiology*; D011499:Protein Processing, Post-Translational / Q000502:physiology; D011960:Receptors, Estrogen / Q000502:physiology; D011981:Receptors, Prolactin / Q000502:physiology; D013629:Tamoxifen / Q000494:pharmacology
D011960:Receptors, Estrogen; D011981:Receptors, Prolactin; D013629:Tamoxifen; D011388:Prolactin