title: The influence of compressive loading on growth of cartilage of the mandibular condyle in vitro.
abstract: The purpose of this study was to clarify the change in mandibular condyles under compressive loading. An organ-culture system of fetal rat mandibular condyles was used, and mechanical loading was generated by compressing the gas phase within a closed chamber. After the culture period, with compressive loading, type I collagen and fibronectin were observed in the lower half of the hypertrophic chondrocyte layer in the mandibular condyles; in contrast, without compressive loading, there was no such reaction. The size of the condyle was not increased by compressive loading. These results suggest that intermittent compressive loading could induce type I collagen and fibronectin production by chondrocytes.
authors.affiliation: Department of Oral Surgery, Nagoya University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nakai
authors.forename: A
authors.initials: A
authors.lastname: Niimi
authors.forename: M
authors.initials: M
authors.lastname: Ueda
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000254:growth & development* / Q000502:physiology; D019902:Chondrocytes / Q000378:metabolism / Q000502:physiology; D003094:Collagen / Q000096:biosynthesis; D019245:Compressive Strength; D015194:Diffusion Chambers, Culture; D005347:Fibroblasts / Q000378:metabolism / Q000502:physiology; D005353:Fibronectins / Q000096:biosynthesis; D007150:Immunohistochemistry; D008335:Mandibular Condyle / Q000254:growth & development* / Q000502:physiology; D008854:Microscopy, Electron; D009924:Organ Culture Techniques; D051381:Rats; D013314:Stress, Mechanical; D016474:Weight-Bearing
chemical_list: D005353:Fibronectins; D003094:Collagen