[The gene of Gorlin's syndrome (basocellular nevomatosis) and the revival of the developmental genes in human carcinogenesis].
Interaction between developmental biology and human pathology has brought new insight on basal cell carcinoma oncogenesis. Alterations of the Patched gene appear to be responsible for the Gorlin syndrome and to be detected in 50% of the sporadic basal cell carcinomas. This relation has recently been extended to all the components of the Hedgehog signalling pathway.
Molès
J P
JP
Laboratoire de dermatologie moléculaire, Institut universitaire de recherche clinique, Montpellier.
D001478:Basal Cell Nevus Syndrome / Q000235:genetics*; D052138:Genes, Neoplasm / Q000235:genetics / Q000502:physiology*; D053823:Hedgehog Proteins; D006801:Humans; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D011506:Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D011956:Receptors, Cell Surface / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled; D012878:Skin Neoplasms / Q000235:genetics*; D000072086:Smoothened Receptor; D015534:Trans-Activators
D053823:Hedgehog Proteins; D009363:Neoplasm Proteins; D011506:Proteins; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; C491023:SMO protein, human; D000072086:Smoothened Receptor; D015534:Trans-Activators