title: [Fas, fas ligand, immune tolerance, and cancer: implications in cancer of the colon].
abstract: Fas and Fas ligand (FasL) are implicated in programmed cell death or apoptosis. In the immunological field, they are particularly important in auto-immunity, graft rejection and anti-tumoral response. Fas ligand expression on thymocytes, activated T lymphocytes, and in sites of immune privilege, suggests the importance of Fas/FasL interactions in negative control of the immune response. The recent description of FasL expression by tumoral cells, represents a new mechanism of immune escape for different cancer, and has been well studied in colon adenocarcinoma.
authors.affiliation: Service de chirurgie générale, digestive et oncologique, Hôpital Laennec, Paris.
authors.forename: A
authors.initials: A
authors.lastname: Berger
authors.forename: B
authors.initials: B
authors.lastname: Piqueras
authors.forename: F
authors.initials: F
authors.lastname: Pages
authors.forename: E
authors.initials: E
authors.lastname: Tartour
authors.forename: P H
authors.initials: PH
authors.lastname: Cugnenc
authors.forename: W H
authors.initials: WH
authors.lastname: Fridman
mesh_terms: D017209:Apoptosis / Q000235:genetics / Q000502:physiology*; D003110:Colonic Neoplasms / Q000276:immunology* / Q000378:metabolism; D053938:DNA Fragmentation; D053222:Fas Ligand Protein; D006801:Humans; D007108:Immune Tolerance; D007111:Immunity, Cellular; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology; D008562:Membrane Glycoproteins / Q000276:immunology / Q000502:physiology*; D014181:Transplantation Immunology; D019014:fas Receptor / Q000276:immunology / Q000502:physiology*
chemical_list: C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; D019014:fas Receptor