[Obstructive renal insufficiency caused by amoxicillin crystalluria].
A 76-year-old woman was admitted to the ICU for a meningitis with rhombencephalitis due to Listeria monocytogenes. The treatment included amoxicillin (250 mg.kg-1.day-1) and gentamicin (3 mg.kg-1.day-1 over 6 days). Neurological outcome was favourable. However at the 14th day, an acute renal failure occurred, following macroscopic haematuria and milkiness urine. CT scan and sonography confirmed the diagnosis of obstructive renal failure with bilateral ureteral obstruction. Crystalluria caused by amoxicillin was suspected. Endoscopic ureteral insertion of double-J catheters permitted the recovery of a normal renal function.
Boursas
M
M
Fédération d'anesthésie-réanimation-Smur, centre hospitalier, Haguenau, France.
Benhassine
L
L
Kempf
J
J
Petit
B
B
Vuillemin
F
F
D058186:Acute Kidney Injury / Q000209:etiology*; D000368:Aged; D000658:Amoxicillin / Q000009:adverse effects* / Q000737:chemistry / Q000627:therapeutic use; D003460:Crystallization; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D004660:Encephalitis / Q000188:drug therapy; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use; D006417:Hematuria / Q000209:etiology; D006801:Humans; D008088:Listeriosis / Q000188:drug therapy; D014517:Ureteral Obstruction / Q000139:chemically induced* / Q000150:complications / Q000628:therapy; D018666:Ureteroscopy; D014546:Urinary Catheterization
D005839:Gentamicins; D000658:Amoxicillin