Synthesis and anticonvulsant properties of new N-piperazinylalkyl imides of succinic acid.
A number of N-[(4-aryl)- or (4-methyl)-l-piperazinyl)alkyl]imides of 3-aryl or 3,3-pentamethylenesuccinic acid were synthesized and tested for anticonvulsant activity in the maximum electroshock seizure (MES) and pentylenetetrazole seizure threshold (scMet) tests. Structures of the novel compounds were confirmed by elemental and spectral analyses.
Obniska
J
J
Department of Pharmaceutical Chemistry, Collegium Medicum of the Jagiellonian University, Kraków, Poland.
Kulig
K
K
Zejc
A
A
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D004597:Electroshock; D051379:Mice; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology; D012640:Seizures / Q000517:prevention & control; D013329:Structure-Activity Relationship; D013386:Succinates / Q000138:chemical synthesis* / Q000494:pharmacology
D000927:Anticonvulsants; D010879:Piperazines; D013386:Succinates