title: Randomized study of chemotherapy and surgery versus radiotherapy for stage IIIA non-small-cell lung cancer: a National Cancer Institute of Canada Clinical Trials Group Study.
abstract: Thirty-one patients with stage IIIA (N2) non-small-cell lung cancer were randomized to receive radiotherapy alone or chemotherapy with cisplatin and vinblastine followed by surgery. Response rates to induction chemotherapy and radiotherapy were 50% and 53.3% respectively. Complete surgical resection was possible for 62.5% of patients. Median survival times were 16.2 and 18.7 months for radiotherapy alone and chemotherapy-surgery respectively (P = Ns), with no long-term improvement in survival seen with combined-modality treatment.
authors.affiliation: Interdepartmental Division of Oncology of the University of Toronto, Ontario, Canada.
authors.forename: F A
authors.initials: FA
authors.lastname: Shepherd
authors.forename: M R
authors.initials: MR
authors.lastname: Johnston
authors.forename: D
authors.initials: D
authors.lastname: Payne
authors.forename: R
authors.initials: R
authors.lastname: Burkes
authors.forename: J
authors.initials: J
authors.lastname: Deslauriers
authors.forename: Y
authors.initials: Y
authors.lastname: Cormier
authors.forename: L D
authors.initials: LD
authors.lastname: de Bedoya
authors.forename: J
authors.initials: J
authors.lastname: Ottaway
authors.forename: K
authors.initials: K
authors.lastname: James
authors.forename: B
authors.initials: B
authors.lastname: Zee
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage; D016019:Survival Analysis; D014747:Vinblastine / Q000008:administration & dosage
chemical_list: D014747:Vinblastine; D002945:Cisplatin