Distribution of nitric oxide in cardiovascular system.
We report here the in vitro measurements of nitric oxide in the cardiovascular system using a porphyrinic sensor specific for NO. Nitric oxide concentrations were measured directly in different parts of the heart and also in different arteries and veins, ranging from 100 microm to 5 mm in diameter. Highest NO. concentrations were found in the heart and particularly in the areas of aortic and pulmonary valves. The NO. concentration in the arteries was higher than in the veins. A clearcut positive correlation was obtained by plotting the vessel diameter and production of nitric oxide.
Mesáros
S
S
Department of Analytical Chemistry, Slovak Technical University, Bratislava, Slovak Republic.
Grunfeld
S
S
D000818:Animals; D000001:Calcimycin / Q000494:pharmacology; D002319:Cardiovascular System / Q000378:metabolism*; D066298:In Vitro Techniques; D007476:Ionophores / Q000494:pharmacology; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D020030:Nitric Oxide Donors / Q000494:pharmacology; D011817:Rabbits
D007476:Ionophores; D020030:Nitric Oxide Donors; D009569:Nitric Oxide; D000001:Calcimycin