[Epidermolysis bullosa acquisita and hepatitis C].
BACKGROUND
Epidermolysis bullosa acquisita is a bullous dermatosis. Its etiology remains unknown and the efficacy of its treatment is low.


METHODS
We report the first association between epidermolysis bullosa acquisita, chronic hepatitis C and cryoglobulinemia, healing with interferon alpha and ribavirine.


CONCLUSIONS
We suggest a role for hepatitis C virus in the pathogenesis of epidermolysis bullosa acquisita. We suppose a synthesis of autoimmune antibodies in a dysimmune environment. Interferon alpha and ribavirine might be a new therapeutic avenue but further studies are necessary to confirm it.
Thiery
S
S
Clinique Dermatologique, Hôpital Edouard Herriot, Lyon.
Misery
L
L
Chossegros
P
P
Kanitakis
J
J
Ghohestani
R
R
Forestier
J Y
JY
Trepo
C
C
Faure
M
M
Claudy
A
A
D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D016107:Epidermolysis Bullosa Acquisita / Q000188:drug therapy* / Q000473:pathology / Q000821:virology*; D005260:Female; D006526:Hepatitis C / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D012254:Ribavirin / Q000627:therapeutic use*
D000998:Antiviral Agents; D016898:Interferon-alpha; D012254:Ribavirin