title: State-dependent stimulus control: cuing attributes of acute cocaine rebound in rats.
abstract: Sprague-Dawley (Rattus norvegicus) rats were trained in a drug discrimination task using the state-dependent interoceptive stimulus attributes of cocaine's delayed or rebound effects (CDE) versus "normal" basal homeostasis. Rats were injected with either 32 mg/kg cocaine or equivalent volumes of saline (SAL), subcutaneously, 13 hr before the sessions. Rats demonstrated > 90% discriminative accuracy. Test sessions showed a time-dependent acute cocaine isodirectional rebound state that engendered a shift from predominantly SAL- to CDE-appropriate responding approximately 7 hr after the high training dose injection and lasted for approximately 10 hr (17 hr postinjection). The delayed or rebound state was dose dependent and engendered only a biphasic partial generalization with acute cocaine injections. There were no detectable levels of cocaine or any of its behaviorally active metabolites at the 13-hr postinjection interval. Tests conducted with various doses of lidocaine, chlordiazepoxide, N-methyl-d-aspartic acid, ketamine, and buspirone engendered SAL- or default-appropriate responding. The anxiogenic drug, pentylenetetrazole, produced partial generalization to the cocaine rebound cue.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, Oklahoma City 73190-3000, USA.
authors.forename: D V
authors.initials: DV
authors.lastname: Gauvin
authors.forename: S A
authors.initials: SA
authors.lastname: Vanecek
authors.forename: T J
authors.initials: TJ
authors.lastname: Baird
authors.forename: R J
authors.initials: RJ
authors.lastname: Briscoe
authors.forename: M
authors.initials: M
authors.lastname: Vallett
authors.forename: K L
authors.initials: KL
authors.lastname: Carl
authors.forename: J A
authors.initials: JA
authors.lastname: Wasielewski
authors.forename: F A
authors.initials: FA
authors.lastname: Holloway
mesh_terms: D000818:Animals; D002707:Chlordiazepoxide / Q000494:pharmacology; D003042:Cocaine / Q000097:blood / Q000494:pharmacology*; D004192:Discrimination, Psychological; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D016202:N-Methylaspartate / Q000494:pharmacology; D009294:Narcotics / Q000097:blood / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012646:Self Administration
chemical_list: D009294:Narcotics; D016202:N-Methylaspartate; D002707:Chlordiazepoxide; D008012:Lidocaine; D003042:Cocaine