Antiprotozoal properties of 16,17-dihydrobrachycalyxolide from Vernonia brachycalyx.
Extracts of the leaves from Vernonia brachycalyx showed in vitro activity against Plasmodium falciparum and promastigotes of Leishmania major. The germacrane dilactone 16,17-dihydrobrachycalyxolide (1) which was previously isolated from the aerial parts of the plant was shown to be the major antiplasmodial principle. An X-ray crystallographic analysis established the absolute configuration and some signals in the NMR spectra were reassigned. 16,17-Dihydrobrachycalyxolide (1) elicited a strong antiplasmodial and antileishmanial activity but also a high toxicity against human lymphocytes.
Oketch-Rabah
H A
HA
Phytochemistry Department, National Museums of Kenya, Nairobi.
Brøgger Christensen
S
S
Frydenvang
K
K
Dossaji
S F
SF
Theander
T G
TG
Cornett
C
C
Watkins
W M
WM
Kharazmi
A
A
Lemmich
E
E
D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D018320:Leishmania major / Q000187:drug effects*; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects*; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D010936:Plant Extracts; D018515:Plant Leaves; D010946:Plants, Medicinal; D045788:Sesquiterpenes, Germacrane / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
C114747:16,17-dihydrobrachycalyxolide; D000981:Antiprotozoal Agents; D010936:Plant Extracts; D045788:Sesquiterpenes, Germacrane