title: [How (deficient) copper causes illness].
abstract: Copper is an essential cofactor in all cells. However, it remains largely unknown how cells deal with this element, which is essential yet toxic. Through the study of microbial model systems on the one hand, and the investigation of inherited diseases in copper metabolism on the other, important insights into the way cells deal with copper can be gained. Two key new elements of copper metabolism have emerged from these studies: ATP-driven copper pumps and intracellular copper transport proteins, the copper chaperones.
authors.affiliation: Institut für Klinische Pharmakologie, Universität Bern. marc.solioz@ikp.unibe.ch
authors.forename: M
authors.initials: M
authors.lastname: Solioz
authors.forename: K D
authors.initials: KD
authors.lastname: Bissig
mesh_terms: D000818:Animals; D002648:Child; D003300:Copper / Q000172:deficiency* / Q000502:physiology; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007706:Menkes Kinky Hair Syndrome / Q000503:physiopathology
chemical_list: D003300:Copper