Adaptation of Madin-Darby canine kidney cells to hypertonic medium: an electron microprobe analysis.
Madin-Darby canine kidney (MDCK) cells of confluent epithelial sheets grown on permeable supports respond to hyperosmotic stress by short- and long-term regulatory volume increase (RVI). Although short-term RVI includes the uptake of inorganic electrolytes, long-term RVI does not and seems therefore to result from accumulation of organic osmolytes.
Borgmann
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Department of Physiology, University of Munich, Germany.
Dörge
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A
D000222:Adaptation, Physiological / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D002460:Cell Line; D020285:Cryoelectron Microscopy; D003470:Culture Media / Q000494:pharmacology; D004285:Dogs; D004577:Electron Probe Microanalysis; D006982:Hypertonic Solutions / Q000494:pharmacology*; D007685:Kidney Tubules, Collecting / Q000166:cytology* / Q000378:metabolism* / Q000648:ultrastructure; D009994:Osmolar Concentration; D012965:Sodium Chloride / Q000494:pharmacology; D014882:Water-Electrolyte Balance / Q000502:physiology
D003470:Culture Media; D006982:Hypertonic Solutions; D012965:Sodium Chloride