Hemorheological, coagulative and fibrinolytic changes during autologous blood donation.
BACKGROUND
Clinical data suggest that autologous blood donation may prevent postsurgical venous thrombosis. If confirmed, this is probably due to beneficial effects in rheologic and hematologic variables which may be changed in patients as a result of repeated bleeding.


METHODS
To ascertain this point, we studied variations in hematological, hemorheological, coagulative and fibrinolytic parameters in 30 patients undergoing autologous blood donation.


RESULTS
Whole blood viscosity (WBV), plasma viscosity and blood viscosity adjusted to 40% hematocrit, progressively and substantially decreased throughout the successive bleeding at all the shear rates considered. WBV was further reduced by presurgical hemodilution with autologous plasma which decreased the platelet and leukocyte count. The hemostasis and fibrinolysis variables, however, underwent no clinically significative changes.


CONCLUSIONS
Repeated bleedings change most hemorheological variables. By decreasing cytocrit and viscosity, reducing aggregability and increasing blood cell deformability an optimal milieu to help prevent thrombosis is artificially created.
Clivillé
X
X
Hospital Universitari de Sant Joan de Reus, Spain. ala@fmcs.urv.es
Bofill
C
C
Joven
J
J
Monasterio
J
J
Viscor
G
G
Vernis
M
M
Angles
A
A
Sans
T
T
D000328:Adult; D000368:Aged; D001777:Blood Coagulation; D001782:Blood Donors; D001804:Blood Transfusion, Autologous; D001809:Blood Viscosity; D005260:Female; D006400:Hematocrit; D006801:Humans; D008297:Male; D008875:Middle Aged