title: Is TAME a potent constrictor of non-airway smooth muscles?
abstract: Under in vitro conditions N-alpha-tosyl L-arginine methyl ester (TAME) induced a concentration dependent contractile response on ileal strips with EC50 of 4.3 x 10(-5) M as compared to acetylcholine which induced sustainable contractions with EC50 of 3.2 x 10(-6) M. The present study is the first to demonstrate that TAME is a potent constrictor of non-airway smooth muscle.
authors.affiliation: Department of Health and Medical Sciences, Faculty of Science, University of Mauritius, Reduit. subratty@dove.uom.ac.mu
authors.forename: A H
authors.initials: AH
authors.lastname: Subratty
authors.forename: J
authors.initials: J
authors.lastname: Moonsamy
mesh_terms: D000818:Animals; D002025:Bufonidae; D007082:Ileum / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects* / Q000502:physiology; D014106:Tosylarginine Methyl Ester / Q000494:pharmacology*
chemical_list: D014106:Tosylarginine Methyl Ester