Clinical significance of combined immunohistochemical detection of CD44v and sialyl LeX expression for colorectal cancer patients undergoing curative resection.
To evaluate their prognostic value, the expressions of CD44v and sialyl LeX (SLX) in colorectal cancers were studied immunohistochemically. Tissue specimens were reacted with monoclonal antibodies (mAb) CD44-1V and CSLEX-1. Of the 145 colorectal cancer patients undergoing curative resection, 59 (40.7%) were positive for mAb CD44-1V, and 40 (27.6%) were positive for mAb CSLEX-1. There was a significant correlation between the combined expression of SLX and CD44v8-10 and lymph node metastasis. The patients with tumors negative for CD44v8-10 and SLX had the most favorable prognoses. Conversely, the patients with tumors positive for both CD44v8-10 and SLX had a high recurrence rate and the poorest prognoses. In a multivariate analysis using the Cox regression model, the combined expression of SLX and CD44v8-10 emerged as an independent prognostic indicator. These results suggested that the combined expression of CD44v8-10 and SLX may be a biologic marker of prognostic significance.
Yamaguchi
A
A
First Department of Surgery, Fukui Medical University, Japan.
Goi
T
T
Seki
K
K
Ohtaki
N
N
Maehara
M
M
Kobayashi
T
T
Niimoto
S
S
Katayama
K
K
Hirose
K
K
Nakagawara
G
G
Matsukawa
S
S
D000911:Antibodies, Monoclonal; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism*; D007150:Immunohistochemistry; D016256:Lewis X Antigen / Q000378:metabolism*; D008207:Lymphatic Metastasis; D008297:Male; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009844:Oligosaccharides / Q000378:metabolism*; D011379:Prognosis; D016016:Proportional Hazards Models; D000080506:Sialyl Lewis X Antigen; D016019:Survival Analysis
D000911:Antibodies, Monoclonal; D018960:Hyaluronan Receptors; D016256:Lewis X Antigen; D009844:Oligosaccharides; D000080506:Sialyl Lewis X Antigen