title: Substantial changes in arterial blood gases during thoracoscopic surgery can be missed by conventional intermittent laboratory blood gas analyses.
abstract: Substantial and clinically relevant changes in arterial blood gases are likely to occur during thoracoscopic surgery with one-lung ventilation (OLV). We hypothesized that they may be missed when using the conventional intermittent blood gas sampling practice. Therefore, during 30 thoracoscopic procedures with OLV, the sampling intervals between consecutive intermittent laboratory blood gas analyses (BGA) were evaluated with respect to changes of PaO2, PaCO2, and pHa ([H+]) using a continuous intraarterial blood gas monitoring system. Frequency and timing of BGA were based on the clinical judgment of 16 experienced anesthesiologists who were blinded to the continuously measured values. Extreme fluctuations of PaO2 (37-625 mm Hg), PaCO2 (27-56 mm Hg), and pHa (7.24-7.51) were observed by continuous blood gas monitoring. During 63% of all sampling intervals, PaO2 decreased >20% compared with the preceding BGA value, which remained undetected by intermittent analysis. In 10 patients with a continuously measured minimal PaO2 value < or = 60 mm Hg, the preceding BGA overestimated this minimal PaO2 by > 47%. Correspondingly, PaCO2 increases of > 10% were observed in 35% of all sampling intervals, and [H+] increases of > 10% were observed in 24% of all sampling intervals. Because these blood gas changes were not reliably detected by using noninvasive monitoring and their magnitude is not predictable during OLV, intermittent BGA with short sampling intervals is warranted. In critical cases, continuous blood gas monitoring may be helpful.
  
  
  CONCLUSIONS
  The magnitude of blood gas changes during thoracoscopic surgery with one-lung ventilation is not predictable and not reliably detected by noninvasive monitoring. Using a continuous intraarterial blood gas monitoring device, we demonstrated that intermittent laboratory blood gas analysis with short sampling intervals is warranted to detect arterial hypoxemia.
authors.affiliation: Institute of Anesthesiology, University Hospital Zurich, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Zaugg
authors.forename: E
authors.initials: E
authors.lastname: Lucchinetti
authors.forename: M P
authors.initials: MP
authors.lastname: Zalunardo
authors.forename: S
authors.initials: S
authors.lastname: Zumstein
authors.forename: D R
authors.initials: DR
authors.lastname: Spahn
authors.forename: T
authors.initials: T
authors.lastname: Pasch
authors.forename: A
authors.initials: A
authors.lastname: Zollinger
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001784:Blood Gas Analysis; D002245:Carbon Dioxide / Q000097:blood; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D012121:Respiration, Artificial; D013906:Thoracoscopy / Q000009:adverse effects*
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen