title: Current management issues of childhood and adult immune thrombocytopenic purpura (ITP).
abstract: The management of acute and chronic immune thrombocytopenic purpura (ITP) of children differs in many aspects from that of adults. Current paediatric and adult treatment options are discussed in this review in the light of the recently published practice guidelines for the diagnosis and treatment of ITP issued by a panel of paediatric and adult haematologists on behalf of the American Society of Hematology. Uncontrolled rather than controlled randomized studies often represent the basis for treatment decisions. Important issues in improving the management of patients with ITP include the identification of research priorities resulting in controlled clinical trials with well-defined study endpoints, the logistics and coordination of research activities and their presentation at international meetings.
authors.affiliation: Division of Oncology/Hematology, University Children's Hospital, Basel, Switzerland.
authors.forename: T
authors.initials: T
authors.lastname: Kühne
authors.forename: G
authors.initials: G
authors.lastname: Elinder
authors.forename: V S
authors.initials: VS
authors.lastname: Blanchette
authors.forename: B
authors.initials: B
authors.lastname: Garvey
mesh_terms: D000208:Acute Disease; D000328:Adult; D002648:Child; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D017713:Platelet Transfusion; D017410:Practice Guidelines as Topic; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000175:diagnosis / Q000628:therapy*; D013156:Splenectomy
chemical_list: D005938:Glucocorticoids; D016756:Immunoglobulins, Intravenous