P-glycoprotein and metallothionein expression and resistance to chemotherapy in osteosarcoma.
The expression of the drug resistance (DR) mediators P-glycoprotein (P-gp) and the metallothioneins (MT) was assessed immunohistochemically in biopsy material from patients with high-grade malignant osteosarcoma (OS). No significant difference was found in survival rate between expressors of both P-gp and MT and non-expressors. Thus, it was concluded that lack of expression of these two drug resistance-related proteins does not appear to confer any advantage in terms of patient survival in osteosarcoma.
Shnyder
S D
SD
Anatomy Unit, School of Molecular & Medical Biosciences, Cardiff, Wales, UK.
Hayes
A J
AJ
Pringle
J
J
Archer
C W
CW
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism*; D001859:Bone Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000401:mortality; D006801:Humans; D008668:Metallothionein / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000378:metabolism*; D012516:Osteosarcoma / Q000188:drug therapy / Q000378:metabolism* / Q000401:mortality; D016019:Survival Analysis
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D009363:Neoplasm Proteins; D008668:Metallothionein