Serum complement C4 levels during acute malarial infection and post-treatment period.
The researches are conducted in adults and children infected with the species P. falciparum and P. vivax. The results indicated that complement C4 level showed a marked fall during the course of acute malaria in both the children and adults infected with both species. A highly significant hypocomplementaemia was recorded (p < 0.01). Children infected with P. falciparum developed acute cerebral malaria, which was associated with marked hypocomplementaemia. A marked rise in C4 level was noticed on 10th day and it was found normal with reference to control, on 20th and 30th day. A considerable reduction in C4 complement was recorded in P. falciparum when compared to P. vivax.
Siddique
M E
ME
Department of Microbiology, J. N. Medical College, Aligarh Muslim University.
Ahmed
S
S
D000208:Acute Disease; D000328:Adult; D002648:Child; D003181:Complement C4 / Q000172:deficiency / Q000378:metabolism*; D006801:Humans; D008288:Malaria / Q000097:blood* / Q000188:drug therapy; D016779:Malaria, Cerebral / Q000097:blood; D016778:Malaria, Falciparum / Q000097:blood; D016780:Malaria, Vivax / Q000097:blood; D013997:Time Factors
D003181:Complement C4