title: Nephropathy and hypertension as manifestations in a 13-y-old girl with primary antiphospholipid syndrome.
abstract: Severe renal hypertension due to both unilateral renal arterial occlusion and renal thrombotic microangiopathy developed in a 13-y-old girl as a manifestation of primary antiphospholipid antibody syndrome. The combination of the intravenous high-dose urokinase therapy and oral anticoagulation therapy, comprising aspirin, warfarin and dipyridamole, was significantly effective in improving her renal function and preventing thrombotic events during an 18-month follow-up period.
authors.affiliation: Department of Paediatrics, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ohtomo
authors.forename: T
authors.initials: T
authors.lastname: Matsubara
authors.forename: K
authors.initials: K
authors.lastname: Nishizawa
authors.forename: A
authors.initials: A
authors.lastname: Unno
authors.forename: T
authors.initials: T
authors.lastname: Motohashi
authors.forename: Y
authors.initials: Y
authors.lastname: Yamashiro
mesh_terms: D000293:Adolescent; D000925:Anticoagulants / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006978:Hypertension, Renovascular / Q000188:drug therapy / Q000209:etiology*; D010960:Plasminogen Activators / Q000627:therapeutic use; D012078:Renal Artery Obstruction / Q000209:etiology*; D013927:Thrombosis / Q000209:etiology*; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator