title: Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21.
abstract: Schizophrenia is a common disorder characterized by psychotic symptoms; diagnostic criteria have been established. Family, twin and adoption studies suggest that both genetic and environmental factors influence susceptibility (heritability is approximately 71%; ref. 2), however, little is known about the aetiology of schizophrenia. Clinical and family studies suggest aetiological heterogeneity. Previously, we reported that regions on chromosomes 22, 3 and 8 may be associated with susceptibility to schizophrenia, and collaborations provided some support for regions on chromosomes 8 and 22 (refs 9-13). We present here a genome-wide scan for schizophrenia susceptibility loci (SSL) using 452 microsatellite markers on 54 multiplex pedigrees. Non-parametric linkage (NPL) analysis provided significant evidence for an SSL on chromosome 13q32 (NPL score=4.18; P=0.00002), and suggestive evidence for another SSL on chromosome 8p21-22 (NPL=3.64; P=0.0001). Parametric linkage analysis provided additional support for these SSL. Linkage evidence at chromosome 8 is weaker than that at chromosome 13, so it is more probable that chromosome 8 may be a false positive linkage. Additional putative SSL were noted on chromosomes 14q13 (NPL=2.57; P=0.005), 7q11 (NPL=2.50, P=0.007) and 22q11 (NPL=2.42, P=0.009). Verification of suggestive SSL on chromosomes 13q and 8p was attempted in a follow-up sample of 51 multiplex pedigrees. This analysis confirmed the SSL in 13q14-q33 (NPL=2.36, P=0.007) and supported the SSL in 8p22-p21 (NPL=1.95, P=0.023).
authors.affiliation: Division of Medical Genetics, University of Geneva Medical School and Cantonal Hospital, Switzerland.
authors.forename: J L
authors.initials: JL
authors.lastname: Blouin
authors.forename: B A
authors.initials: BA
authors.lastname: Dombroski
authors.forename: S K
authors.initials: SK
authors.lastname: Nath
authors.forename: V K
authors.initials: VK
authors.lastname: Lasseter
authors.forename: P S
authors.initials: PS
authors.lastname: Wolyniec
authors.forename: G
authors.initials: G
authors.lastname: Nestadt
authors.forename: M
authors.initials: M
authors.lastname: Thornquist
authors.forename: G
authors.initials: G
authors.lastname: Ullrich
authors.forename: J
authors.initials: J
authors.lastname: McGrath
authors.forename: L
authors.initials: L
authors.lastname: Kasch
authors.forename: M
authors.initials: M
authors.lastname: Lamacz
authors.forename: M G
authors.initials: MG
authors.lastname: Thomas
authors.forename: C
authors.initials: C
authors.lastname: Gehrig
authors.forename: U
authors.initials: U
authors.lastname: Radhakrishna
authors.forename: S E
authors.initials: SE
authors.lastname: Snyder
authors.forename: K G
authors.initials: KG
authors.lastname: Balk
authors.forename: K
authors.initials: K
authors.lastname: Neufeld
authors.forename: K L
authors.initials: KL
authors.lastname: Swartz
authors.forename: N
authors.initials: N
authors.lastname: DeMarchi
authors.forename: G N
authors.initials: GN
authors.lastname: Papadimitriou
authors.forename: D G
authors.initials: DG
authors.lastname: Dikeos
authors.forename: C N
authors.initials: CN
authors.lastname: Stefanis
authors.forename: A
authors.initials: A
authors.lastname: Chakravarti
authors.forename: B
authors.initials: B
authors.lastname: Childs
authors.forename: D E
authors.initials: DE
authors.lastname: Housman
authors.forename: H H
authors.initials: HH
authors.lastname: Kazazian
authors.forename: S
authors.initials: S
authors.lastname: Antonarakis
authors.forename: A E
authors.initials: AE
authors.lastname: Pulver
mesh_terms: D000328:Adult; D002882:Chromosomes, Human, Pair 13; D002898:Chromosomes, Human, Pair 8; D004198:Disease Susceptibility; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D006801:Humans; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats; D008957:Models, Genetic; D012559:Schizophrenia / Q000235:genetics*