title: Focal cortical dysplasia with glioproliferative changes causing seizures: report of 3 cases.
abstract: In contrast to neoplasia, lesions of focal cerebral dysplasia are thought to be completed developmental processes of abnormal neuronal migration. We present three children with seizures resulting from brain lesions which pathologically demonstrate regions of both clearcut focal cortical dysplasia and also hypercellularity and monomorphism typical of proliferative lesions such as low grade glial tumor. These cases suggest the existence of a distinct subgroup of patients with prominent glioproliferative changes in association with focal cortical dysplasia, challenging the conventional dichotomy between dysplastic and proliferative categories of brain lesions. Recognition of patients with dual pathology may be of practical as well as theoretical importance.
authors.affiliation: Department of Neurosurgery, Children's Hospital, Boston, Mass., USA. madsen_j@a1.tch.harvard.edu
authors.forename: J R
authors.initials: JR
authors.lastname: Madsen
authors.forename: A V
authors.initials: AV
authors.lastname: Vallat
authors.forename: T Y
authors.initials: TY
authors.lastname: Poussaint
authors.forename: R M
authors.initials: RM
authors.lastname: Scott
authors.forename: U
authors.initials: U
authors.lastname: De Girolami
authors.forename: D C
authors.initials: DC
authors.lastname: Anthony
mesh_terms: D001932:Brain Neoplasms / Q000150:complications* / Q000473:pathology* / Q000601:surgery; D002465:Cell Movement / Q000502:physiology*; D002540:Cerebral Cortex / Q000473:pathology* / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009457:Neuroglia / Q000473:pathology*