[Effect of opioid peptides on immunomodulation].
Activation of the opioid receptors by delta-agonist DSLET and by kappa-agonist rimorphin led to a significant inhibition of plaque-forming and rosette-forming cells in the CBA mice. On the other hand, mu-agonist DAGO stimulated the immune response on the 4th and 5th days after immunization with SRBC (5 x 10(8)). Lesion of the hypothalamo-hypophyseal connection prevented immuno-stimulating as well as immuno-depressive effects. The latter seems to be due to an interaction with the serotoninergic system, whereas immuno-stimulating effect involves the dopaminergic system.
Cheĭdo
M A
MA
Institute of Physiology of the Russian Acad. Med. Sci., Siberian Branch, Novosibirsk.
Idova
G V
GV
D000818:Animals; D003533:Cyproheptadine / Q000494:pharmacology; D065127:Dopamine D2 Receptor Antagonists; D004399:Dynorphins / Q000494:pharmacology; D004723:Endorphins / Q000494:pharmacology; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives / Q000494:pharmacology; D004745:Enkephalins / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D015213:Neuroimmunomodulation / Q000187:drug effects* / Q000276:immunology; D010902:Pituitary Gland / Q000276:immunology / Q000502:physiology; D044402:Receptor, Serotonin, 5-HT2A; D017448:Receptors, Dopamine D2 / Q000276:immunology; D011957:Receptors, Opioid / Q000819:agonists* / Q000276:immunology; D017465:Receptors, Opioid, delta / Q000819:agonists / Q000276:immunology; D017473:Receptors, Opioid, kappa / Q000819:agonists / Q000276:immunology; D017450:Receptors, Opioid, mu / Q000819:agonists / Q000276:immunology; D011985:Receptors, Serotonin / Q000187:drug effects / Q000276:immunology; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000276:immunology
D065127:Dopamine D2 Receptor Antagonists; D004723:Endorphins; D004745:Enkephalins; D044402:Receptor, Serotonin, 5-HT2A; D017448:Receptors, Dopamine D2; D011957:Receptors, Opioid; D017465:Receptors, Opioid, delta; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu; D011985:Receptors, Serotonin; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D003533:Cyproheptadine; D004743:Enkephalin, Leucine; D004399:Dynorphins; C034318:enkephalin, Ser(2), Leu(5), Thr(6)-; C036200:rimorphin; D006220:Haloperidol