Antimalarial activities of polyhydroxyphenyl and hydroxamic acid derivatives.
Several known mammalian ribonucleotide reductase inhibitors featuring a polyhydroxyphenyl and/or hydroxamate moiety as the active group were screened for potency in inhibiting growth of the malaria parasite Plasmodium falciparum. Compounds containing a 2,3- or 3,4-dihydroxyphenyl group as well as benzohydroxamate appear to be the most effective inhibitors of the malaria parasite.
Holland
K P
KP
Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, Florida 32611, USA.
Elford
H L
HL
Bracchi
V
V
Annis
C G
CG
Schuster
S M
SM
Chakrabarti
D
D
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D006877:Hydroxamic Acids / Q000494:pharmacology*; D006918:Hydroxyurea / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects; D012264:Ribonucleotide Reductases / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
D000962:Antimalarials; D006877:Hydroxamic Acids; D012264:Ribonucleotide Reductases; D006918:Hydroxyurea