The delta1-opioid receptor antagonist, 7-(benzospiroindanyl)naltrexone [correction of 7-benzylspiroindanylnaltrexone], prolongs renal allograft survival in a rat model.
In this study we demonstrate allograft survival in a rat model of renal transplantation using the delta1-opioid receptor antagonist, 7-(benzospiroindanyl)naltrexone [corrected]. Treatment with 7-(benzospiroindanyl)naltrexone [corrected] caused 50% of the rats to survive longer than 100 days (untreated, 11 +/- 3 days). Naltrindole, a delta-opioid receptor antagonist without subtype selectivity, also promoted graft survival but was substantially less effective, suggesting that antagonism at delta1-opioid receptors is involved in allograft survival.
Linner
K M
KM
Minneapolis Medical Research Foundation, MN 55404, USA.
Stickney
B J
BJ
Quist
H E
HE
Sharp
B M
BM
Portoghese
P S
PS
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006085:Graft Survival / Q000187:drug effects*; D016030:Kidney Transplantation / Q000276:immunology*; D009271:Naltrexone / Q000031:analogs & derivatives / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000494:pharmacology; D051381:Rats; D011915:Rats, Inbred BUF; D011917:Rats, Inbred Lew; D017465:Receptors, Opioid, delta / Q000037:antagonists & inhibitors* / Q000145:classification; D013141:Spiro Compounds / Q000494:pharmacology*
D009292:Narcotic Antagonists; D017465:Receptors, Opioid, delta; D013141:Spiro Compounds; D009271:Naltrexone; C055382:naltrindole