Oral pancreatic enzyme therapy in the control of diabetes mellitus in tropical calculous pancreatitis.
CONCLUSIONS
Pancreatic enzyme supplementation therapy conducted during a 6 mo period produces better control of diabetes, improvement in nutrition, and overall improvement in quality of life in patients with tropical calculous pancreatitis.


BACKGROUND
Tropical calculous pancreatitis is characterized by abdominal pain, pancreatic calculi, and diabetes. The diabetes in insulin resistant. The brittle diabetes may be owing to defective glucagon secretion and erratic absorption of nutrients.


METHODS
Patients with tropical calculous pancreatitis with diabetes and chronic pancreatitis were studied for fasting and postprandial plasma glucose, glycosylated hemoglobin, serum cholesterol, triglycerides, and calcium, liver function, and plasma C-peptide. All patients were given Creon and evaluated for quality of life.


RESULTS
Clinical parameters of the patients showed considerable improvement at the end of the trial. Abdominal pain, steatorrhea, and sense of well being improved. There was a significant reduction in postprandial plasma glucose and glycosylated hemoglobin.
Mohan
V
V
Madras Diabetes Research Foundation, Gopalapuram, India.
Poongothai
S
S
Pitchumoni
C S
CS
D000284:Administration, Oral; D000328:Adult; D001774:Blood Chemical Analysis; D001786:Blood Glucose / Q000032:analysis; D002137:Calculi; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D008297:Male; D010194:Pancreatin / Q000009:adverse effects / Q000627:therapeutic use*; D010195:Pancreatitis / Q000150:complications / Q000188:drug therapy*
D001786:Blood Glucose; D010194:Pancreatin