Insulin sensitivity and sex steroid hormone levels during the menstrual cycle in healthy women with non-insulin-dependent diabetic parents.
OBJECTIVE
To identify the effect of the menstrual cycle and sex steroid hormone levels on insulin sensitivity in healthy women with non-insulin-dependent diabetic parents.


METHODS
A clinical trial was realized in 6 healthy women with non-insulin-dependent diabetic parents and in 6 control subjects. In both phases of the menstrual cycle the following tests were made: insulin tolerance test, metabolic profile, and sex steroid hormone levels.


RESULTS
Insulin sensitivity was significantly lower in the follicular (p = 0.004) and luteal (p = 0.01) phases of the menstrual cycle in probands compared with controls. In the luteal phase dehydroepiandrosterone was higher in probands than in controls (p = 0.009).


CONCLUSIONS
Healthy women with non-insulin-dependent diabetic parents had a lower insulin sensitivity in both phases of the menstrual cycle compared with the control group. Dehydroepiandrosterone was higher in the luteal phase in probands than controls.
González-Ortiz
M
M
Clinical Epidemiology Research Unit, Western National Medical Center, Mexican Institute of Social Security, and Physiology Department, Health Science Center, University of Guadalajara, Guadalajara City, Mexico.
Martínez-Abundis
E
E
Lifshitz
A
A
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D003687:Dehydroepiandrosterone / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D004958:Estradiol / Q000097:blood; D005260:Female; D005498:Follicular Phase / Q000097:blood; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood*; D007700:Kinetics; D008183:Luteal Phase / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D008597:Menstrual Cycle / Q000097:blood*; D010290:Parents; D011388:Prolactin / Q000097:blood; D013739:Testosterone / Q000097:blood
D001786:Blood Glucose; D012739:Gonadal Steroid Hormones; D007328:Insulin; D013739:Testosterone; D003687:Dehydroepiandrosterone; D004958:Estradiol; D011388:Prolactin; D007986:Luteinizing Hormone