SIVrcm infection of macaques.
In a prior report, we described the isolation and characterization of SIVrcm, a distinct primate lentivirus found in a household pet Red-Capped Mangabey (RCM) in Gabon. SIVrcm is divergent from HIV-1 and HIV-2/SIV families of primate lentiviruses. In this report, additional in vitro replication studies and the results of SIVrcm infection in macaques are presented. SIVrcm causes little cytopathic effedct in Molt 4 Clone 8 cells and in rhesus and human PBMCs. In vivo, SIVrcm is non-pathogenic after 200 days in rhesus macaques and after one year in cynomolgous macaques, but does cause a chronic infection in both macaques.
Smith
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SM
The Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA. ssmith@adarc.org
Makuwa
M
M
Lee
F
F
Gettie
A
A
Russo
C
C
Marx
P A
PA
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000503:physiopathology; D000818:Animals; D000829:Animals, Domestic; D000917:Antibody Formation; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D016664:Cercocebus / Q000821:virology*; D004279:DNA, Viral / Q000302:isolation & purification; D005681:Gabon; D015497:HIV-1 / Q000235:genetics; D015498:HIV-2 / Q000235:genetics; D006801:Humans; D018655:Lymphocyte Count; D008252:Macaca fascicularis; D016133:Polymerase Chain Reaction; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000503:physiopathology* / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D014779:Virus Replication
D004279:DNA, Viral