title: Residual beta-cell function and spontaneous clinical remission in type 1 diabetes mellitus: the role of puberty.
abstract: To investigate the role of puberty on spontaneous clinical remission and on secretion of residual C-peptide during the first year of type 1 diabetes mellitus, we studied 77 pre-pubertal, 39 pubertal and 41 post-pubertal type 1 diabetic patients. Spontaneous partial clinical remission (HbA1c within the normal range and insulin dose less than 0.3 U x kg(-1) body weight x day(-1) lasting for at least 10 days) decreased with duration of diabetes: months 3 vs 6 vs 12, respectively 13 vs 7 vs 4% (P<0.025). Remission was higher in post-pubertal than pubertal and prepubertal patients: month 6 respectively 20 vs 5 vs 1% (P<0.001). Secretion of C-peptide was significantly lower in pre-pubertal than the other two groups of patients. Basal and stimulated C-peptide secretion were higher in patients in clinical remission than in those who were not: basal value 0.4 (0.26-0.53) vs 0.28 (0.14-0.4) nmol/l (P<0.05); stimulated value 0.63 (0.5-0.95) vs 0.56 (0.31-0.74) nmol/l (P<0.05). Spontaneous remission is less frequent in children and adolescent patients than in adult post-pubertal patients, but different mechanisms may be involved. Low residual insulin secretion seems implicated in children meanwhile low insulin sensitivity could be more important in pubertal patients.
authors.affiliation: Clinica Pediatrica III, Scientific Institute, H San Raffaele, Milano, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Bonfanti
authors.forename: E
authors.initials: E
authors.lastname: Bognetti
authors.forename: F
authors.initials: F
authors.lastname: Meschi
authors.forename: A
authors.initials: A
authors.lastname: Brunelli
authors.forename: M C
authors.initials: MC
authors.lastname: Riva
authors.forename: M R
authors.initials: MR
authors.lastname: Pastore
authors.forename: G
authors.initials: G
authors.lastname: Calori
authors.forename: G
authors.initials: G
authors.lastname: Chiumello
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism*; D008297:Male; D011627:Puberty / Q000502:physiology*; D012075:Remission, Spontaneous
chemical_list: D007328:Insulin