title: O2-binding to fully reduced cytochrome aa3 reexamined using SVD analysis of simulated and real data.
abstract: Using new time-resolved multichannel experimental and simulated data, analyzed by SVD, it is concluded that the second order binding rate constant for O2-binding to fully reduced mammalian cytochrome aa3 is approximately five times higher than the currently accepted value of approximately 1.5 x 10(8) M-1 s-1.
authors.affiliation: Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892, USA.
authors.forename: R W
authors.initials: RW
authors.lastname: Hendler
authors.forename: R I
authors.initials: RI
authors.lastname: Shrager
mesh_terms: D003198:Computer Simulation; D003576:Electron Transport Complex IV / Q000737:chemistry / Q000378:metabolism*; D007700:Kinetics; D008432:Mathematical Computing; D008956:Models, Chemical; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism*
chemical_list: D003576:Electron Transport Complex IV; D010100:Oxygen