title: [The hypereosinophilic variant of Ph'-positive chronic myeloleukemia].
abstract: OBJECTIVE
  To confirm clonal nature of idiopathic hypereosinophilic syndrome (IHES), its relevance to Ph'-positive chronic myeloid leukemia.
  
  
  METHODS
  3 cases of idiopathic hypereosinophilic syndrome are reported with morphologic analysis of bone marrow cells and cytogenetic examinations. In one patient the presence of Ph'-chromosome was confirmed at fluorescent in situ hybridization (FISH) and molecular-genetic analysis (bcr/abl). Samples of bone marrow, spleen and liver were examined pathohistologically.
  
  
  RESULTS
  The presence of chromosome anomaly t(9;22), i.e. Ph'-chromosome, associated with chronic myeloid leukemia (CML) was identified in all the 3 cases. There was also myeloid hyperplasia in the bone marrow (with primarily mature, eosinophilic granulocytes), spleen and liver, depression of megakaryocyto- and erythropoiesis. 2 patients had similar clinical symptoms which was not typical for CML in chronic phase: fever, elevated ESR, clear-cut anemia and thrombocytopenia. In the absence of hyperleukocytosis, blood and bone marrow eosinophils remained high (42.5, 21.5, 42.5% and 21.4, 7.1, 6.5%, respectively) due to "mature" forms. The number of blasts in the bone marrow was maximum 2.4%.
  
  
  CONCLUSIONS
  The literature and the obtained data suggest closeness of idiopathic hypereosinophilic syndrome and Ph'-positive CML within myeloproliferative diseases.
authors.forename: N D
authors.initials: ND
authors.lastname: Khoroshko
authors.forename: R A
authors.initials: RA
authors.lastname: Mokeeva
authors.forename: A G
authors.initials: AG
authors.lastname: Turkina
authors.forename: N V
authors.initials: NV
authors.lastname: Arkhipova
authors.forename: E A
authors.initials: EA
authors.lastname: Semenova
authors.forename: A V
authors.initials: AV
authors.lastname: Zakharova
authors.forename: Iu N
authors.initials: IuN
authors.lastname: Kobzev
authors.forename: K K
authors.initials: KK
authors.lastname: Sakhibzadaeva
authors.forename: A F
authors.initials: AF
authors.lastname: Tagiev
mesh_terms: D000328:Adult; D001344:Autopsy; D001706:Biopsy; D002908:Chronic Disease; D017809:Fatal Outcome; D016313:Genes, abl / Q000235:genetics; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000235:genetics / Q000473:pathology*; D007085:Ilium / Q000473:pathology; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics / Q000473:pathology*; D008099:Liver / Q000473:pathology; D008297:Male; D013154:Spleen / Q000473:pathology