title: Comparative grepafloxacin phototoxicity in mouse skin.
abstract: This study was performed in order to compare the phototoxic potential of grepafloxacin (a new fluoroquinolone for the treatment of respiratory tract infections) with that of a number of marketed fluoroquinolones. Groups of Balb/c mice received either control material or grepafloxacin, lomefloxacin, sparfloxacin, ofloxacin, ciprofloxacin or enoxacin at an oral dose of 200 mg/kg before being exposed to 20 J/cm2 longwave ultraviolet irradiation for 110-115 min. Lomefloxacin and sparfloxacin caused erythema and oedema which were often severe and lasted the full 7 days of the study. Enoxacin caused a long-lasting erythema, while the erythema seen following the administration of grepafloxacin, ciprofloxacin and ofloxacin was relatively mild and short-lived. The results of this study demonstrate the good safety profile of grepafloxacin in terms of phototoxicity.
authors.affiliation: GlaxoWellcome Research and Development, Ware, Hertfordshire, UK.
authors.forename: K
authors.initials: K
authors.lastname: Owen
mesh_terms: D000505:Alopecia / Q000139:chemically induced; D000818:Animals; D000890:Anti-Infective Agents / Q000633:toxicity*; D017484:Dermatitis, Phototoxic; D004487:Edema / Q000139:chemically induced; D004890:Erythema / Q000139:chemically induced; D005260:Female; D024841:Fluoroquinolones; D051379:Mice; D008807:Mice, Inbred BALB C; D010879:Piperazines / Q000633:toxicity*; D015363:Quinolones / Q000633:toxicity*; D012867:Skin / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D014466:Ultraviolet Rays
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D010879:Piperazines; D015363:Quinolones; C075375:grepafloxacin