title: Neurotransmitter actions on oral pontine tegmental neurons of the rat: an in vitro study.
abstract: The actions of neurotransmitters involved in the sleep-wakefulness cycle on neurons located in the ventral part of the oral pontine tegmentum were studied in a rat brain-slice preparation. Results show that glutamate and histamine evoke depolarizations and spike firing while serotonin and gamma-aminobutyric acid evoke hyperpolarizations. The excitatory and inhibitory actions of these neurotransmitters increase pontine neuron activity during the conditions occurring during paradoxical sleep.
authors.affiliation: Departamento de Morfología, Facultad de Medicina, Universidad Autónoma de Madrid, Arzobispo Morcillo s/n., 28029, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Nuñez
authors.forename: W
authors.initials: W
authors.lastname: Buño
authors.forename: F
authors.initials: F
authors.lastname: Reinoso-Suárez
mesh_terms: D000818:Animals; D018698:Glutamic Acid / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D009055:Mouth / Q000502:physiology*; D009474:Neurons / Q000187:drug effects; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D011149:Pons / Q000166:cytology / Q000187:drug effects* / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000494:pharmacology; D012895:Sleep, REM / Q000502:physiology; D013681:Tegmentum Mesencephali / Q000166:cytology / Q000187:drug effects* / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
chemical_list: D018377:Neurotransmitter Agents; D012701:Serotonin; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D006632:Histamine