title: [Importance of a multidisciplinary approach to metastatic cancer of the rectum].
abstract: Management of rectal cancers with synchronous metastasis is difficult. We evaluated in 23 patients a combination of pelvic radiotherapy at the dose of 45 Gy in 5 weeks and 25 fractions with chemotherapy by 5-fluorouracil (350 mg/m2/day) and folinic acid (20 mg/m2/day) for 5 days at the time of the first and the fifth week of the irradiation. Surgery was indicated firstly in cases of stricture or secondarily for resection of the primary location and, when possible, of the metastasis. General state of health of the patients improved in 35%, symptomatology in 86% and comfort in 72% of the cases. Response rates for the primary tumor were 41% of partial response and 50% of stable disease. For the metastatic lesions, they were 9% and 59% respectively. Sixty-one per cent of patients were secondarily operated with resection of the primary tumor in 12 cases and of hepatic metastases in 2 cases. The median survival and the median survival without progression were respectively 13 and 9 months. Radiochemotherapy combination as the first treatment was beneficial in 4/5 of the patients presenting a rectal cancer with synchronous metastasis and allowed us to select those that would secondarily benefit from a surgical resection.
authors.affiliation: Service de gastroentérologie, Institut Gustave-Roussy.
authors.forename: E
authors.initials: E
authors.lastname: Mitry
authors.forename: P L
authors.initials: PL
authors.lastname: Pompili
authors.forename: P
authors.initials: P
authors.lastname: Rougier
authors.forename: C
authors.initials: C
authors.lastname: Toma
authors.forename: M
authors.initials: M
authors.lastname: Ducreux
authors.forename: A
authors.initials: A
authors.lastname: Lusinchi
authors.forename: D
authors.initials: D
authors.lastname: Elias
authors.forename: M C
authors.initials: MC
authors.lastname: Fabri
authors.forename: J
authors.initials: J
authors.lastname: Bourhis
authors.forename: J
authors.initials: J
authors.lastname: Kac
authors.forename: F
authors.initials: F
authors.lastname: Eschwege
authors.forename: P
authors.initials: P
authors.lastname: Lasser
mesh_terms: D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D016879:Salvage Therapy