title: [Ki-1+ large-cell anaplastic lymphoma with a leukemic appearance. Study of a case].
abstract: Ki-1 anaplastic large cell lymphoma is a well-described subtype of non-Hodgkin's lymphoma with distinctive characteristics from the cytological, immunohistochemical and clinical points of view. One of the clinical behavior characteristic is that it rarely evolves into a leukaemic phase. We report the case of a 72-year-old man in which the appearance of tumor cells in peripheral blood was one of the most revealing information. The patient showed B-symptoms, bicytopenia and bone marrow involvement, together with hepatosplenomegaly and right axilar adenopathy, which after biopsied lead to Ki-1 anaplastic large cell lymphoma's diagnosis (stage IV-B). As far as the treatment and evolution are concerned, we choose a polychemotherapy (ACOP-B) because of the patient's age. Up to now clinical and analitical course is excellent and the patient is now in remission.
authors.affiliation: Servicio de Hematología, Hospital Reina Sofía, Tudela, Navarra.
authors.forename: P
authors.initials: P
authors.lastname: Rabasa
authors.forename: J M
authors.initials: JM
authors.lastname: Domingo
authors.forename: D
authors.initials: D
authors.lastname: Quílez
authors.forename: F
authors.initials: F
authors.lastname: Monzón
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D003520:Cyclophosphamide / Q000008:administration & dosage; D006801:Humans; D017728:Lymphoma, Large-Cell, Anaplastic / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D009360:Neoplastic Cells, Circulating; D012074:Remission Induction
chemical_list: D003520:Cyclophosphamide