Modulation of cell calcium signals by mitochondria.
It is now clearer and clearer that mitochondria play a role, and perhaps an active role, in cell calcium signalling. The fact that mitochondria can exhibit a Ca2+-induced Ca2+ release (mCICR, Ichas et al. [37]) reinforces this concept and makes the mitochondria an essential element in the relay of Ca2+ wave propagation. It must be emphasized that the modulation of cell Ca2+ signals by mitochondria depends upon their energetic status, thus making mitochondria an essential link between energy metabolism and calcium signalling inside the cell.
Jouaville
L S
LS
CJF INSERM 97-05, Université Victor Ségalen, Bordeaux 2, France.
Ichas
F
F
Mazat
J P
JP
D000227:Adenine Nucleotides / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000502:physiology; D002463:Cell Membrane Permeability / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D008564:Membrane Potentials / Q000502:physiology; D008928:Mitochondria / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
D000227:Adenine Nucleotides; D015220:Calcium Channels; D004791:Enzyme Inhibitors; D002118:Calcium