title: Early developmental stages of psychopathology study (EDSP): objectives and design.
abstract: The primary and secondary objectives of the Early Developmental Stages of Substance Abuse Study (EDSP) are described along with a detailed description of the overall design, special design features and instruments used. The EDSP is a 5-year prospective study with three waves of assessments. Special design features are the linkages with family genetic investigations as well as neuroendocrinological stress tests in high-risk subjects. Overall, 3,021 adolescents and young adults aged 14-24 years are included. The response rate for the baseline investigation was 71%. Diagnostic assessments were made by using a modified lifetime (baseline) and 12-month change version of the WHO-CIDI, adjusted for DSM-IV. Modifications refer to a more detailed quantitative assessment of symptoms and substance use variables as well as the inclusion of questions to assess course of disorders and subthreshold diagnostic conditions.
authors.affiliation: Max Planck Institute of Psychiatry, Clinical Psychology and Epidemiology Unit, Munich, Germany.
authors.forename: H U
authors.initials: HU
authors.lastname: Wittchen
authors.forename: A
authors.initials: A
authors.lastname: Perkonigg
authors.forename: G
authors.initials: G
authors.lastname: Lachner
authors.forename: C B
authors.initials: CB
authors.lastname: Nelson
mesh_terms: D000293:Adolescent; D000328:Adult; D004812:Epidemiologic Methods; D005858:Germany / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D001523:Mental Disorders / Q000175:diagnosis / Q000453:epidemiology*; D015995:Prevalence; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D012307:Risk Factors; D012494:Sampling Studies; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000453:epidemiology*