Anticonvulsant effect of SL 75 102 in adult and immature rats.
The anticonvulsant action of SL 75 102, a metabolite of Progabide, was studied in a model of pentylenetetrazol-induced motor seizures in adult and 12-day-old rats. SL 75 102 suppressed generalized tonic-clonic seizures in adult rats and restricted the tonic phase of these seizures in rat pups. SL 75 102 was less effective than Progabide. In addition, some minor differences in anticonvulsant actions of these two drugs were observed.
Kubová
H
H
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague.
Haugvicová
R
R
Mares
P
P
D000375:Aging; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D010433:Pentylenetetrazole; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
D000927:Anticonvulsants; D005680:gamma-Aminobutyric Acid; C017984:progabide acid; D010433:Pentylenetetrazole