title: Novel approaches to the discovery of antimicrobial agents.
abstract: With the completion of numerous bacterial genome sequences, the discovery of antibacterial drugs has fully entered the genomic era. The strategies for effectively using genomic information for target identification, target characterization, screen development and compound evaluation are emerging, and have greatly increased the number of antibacterial targets available for screening. Fortunately, simultaneous efforts in improving miniaturization, robotics and database tools are underway so that the potential of genomics can be realized.
authors.affiliation: Microcide Pharmaceuticals Inc, Mountain View, CA 94043, USA. MSCHMID@Microcide.com
authors.forename: M B
authors.initials: MB
authors.lastname: Schmid
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005798:Genes, Bacterial; D020043:Genes, Essential; D016680:Genome, Bacterial; D017422:Sequence Analysis, DNA
chemical_list: D000890:Anti-Infective Agents