title: [The short-acting insulin analog Lispro (Humalog) in the treatment of diabetes--comparison of preprandial and postprandial administration and comparison with treatment using Humulin R].
abstract: The results of a clinical trial comprising 162 type 1 and 2 diabetics who took for 12 weeks Humalog in cartridges revealed that administration of this insulin before or 20 minutes after a meal does not affect the blood sugar level in a major way. None of the patients developed after Humalog administration local or general allergic manifestations. Hypoglycaemic episodes grade I and II were not more frequent during treatment with human insulins. The mean compensation of diabetes (HbA1c) remained unchanged. 80% of the diabetics are statistically significantly satisfied with Humalog treatment as compared with Humulinem R administration.
authors.affiliation: Diabetologické centrum VFN, III. interní klinika 1, Praha.
authors.forename: J
authors.initials: J
authors.lastname: Perusicová
authors.forename: J M
authors.initials: JM
authors.lastname: Svehelka
mesh_terms: D000328:Adult; D003920:Diabetes Mellitus / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D007328:Insulin / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D061268:Insulin Lispro; D008297:Male
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin; D061268:Insulin Lispro