title: Ontogenetic and regional changes in alpha-methyl-D-glucoside and L-proline intestinal transport in guinea pig.
abstract: Regional brush-border uptakes of alpha-methyl-D-glucose and L-proline as well as morphometric parameters were studied from birth until adulthood in guinea pig small intestine. Intestinal weight, length, and area were fitted to two-segmented straight lines: from birth until the 2nd wk there was a sharp rise, whereas from day 14 to the adult stage the increase was slower. In everted sleeves, total uptakes of alpha-methyl-D-glucoside were higher on day 1 in duodenum, jejunum, and ileum, diminishing with increasing age. The initial fluxes of L-proline were higher during the 1st wk, diminishing to values that kept constant thereafter. Total uptakes of L-proline relative to alpha-methyl-D-glucoside showed a peak in the 1st wk in the three segments studied, reflecting the high demand for protein during the postnatal period. Regional ratios of L-proline to alpha-methyl-D-glucoside indicated that the ileum is the segment best suited to transporting this amino acid during the first 3 wk. Changes observed in the present study indicated a different pattern between hexose and amino acid transport during development and along the small intestine of guinea pig.
authors.affiliation: Grup de Transport Intestinal, Departament de Fisiologia-Divisió IV, Facultat de Farmàcia, Universitat de Barcelona, E-08028 Barcelona, Spain.
authors.forename: M E
authors.initials: ME
authors.lastname: Juan
authors.forename: M C
authors.initials: MC
authors.lastname: Turmo
authors.forename: J M
authors.initials: JM
authors.lastname: Planas
mesh_terms: D000818:Animals; D006168:Guinea Pigs; D007082:Ileum / Q000378:metabolism; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000033:anatomy & histology / Q000254:growth & development; D007422:Intestines / Q000254:growth & development*; D007583:Jejunum / Q000378:metabolism; D007700:Kinetics; D008297:Male; D008757:Methylglucosides / Q000378:metabolism*; D008871:Microvilli / Q000378:metabolism; D009747:Nutritional Physiological Phenomena; D011392:Proline / Q000378:metabolism*; D015430:Weight Gain
chemical_list: D008757:Methylglucosides; C027020:methylglucoside; D011392:Proline