Reduced number and altered morphology of microglial cells in colony stimulating factor-1-deficient osteopetrotic op/op mice.
The numerical density of microglial cells is reduced by 47% in the corpus callosum, by 37% in the parietal cortex and by 34% in the frontal cortex of mice mutant at the op locus which are totally devoid of colony stimulating factor-1 (CSF-1), the major growth factor for macrophages. Moreover, microglia in the frontal cortex of the op/op mice are smaller and have shorter cytoplasmic processes compared to control mice. Study suggests that CSF-1 plays a role in vivo in the formation and maturation of microglia and has little or no effect on perivascular cells.
Wegiel
J
J
New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York, NY 10314, USA.
Wiśniewski
H M
HM
Dziewiatkowski
J
J
Tarnawski
M
M
Kozielski
R
R
Trenkner
E
E
Wiktor-Jedrzejczak
W
W
D000818:Animals; D001921:Brain / Q000473:pathology*; D002452:Cell Count; D003337:Corpus Callosum / Q000473:pathology; D005625:Frontal Lobe / Q000473:pathology; D007150:Immunohistochemistry; D016173:Macrophage Colony-Stimulating Factor / Q000172:deficiency*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics; D017628:Microglia / Q000473:pathology*; D009154:Mutation; D010022:Osteopetrosis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D010296:Parietal Lobe / Q000473:pathology
D016173:Macrophage Colony-Stimulating Factor