title: -Curative and preventive antibiotic therapy in infective endocarditis-.
abstract: Durack's criteria, including echocardiographic manifestations, are the current standard for the diagnosis of infective endocarditis (IE). The most common microorganisms known to cause IE are streptococci and staphylococci, and therapeutic principles are based on an association of parenteral antibiotics, as far as possible bactericidal and prolonged. Treatment also includes the search for the source of infection and its eradication. IE with negative blood cultures requires special techniques to obtain the causal microorganisms. In about half of the cases, a nosocomial bacteriaemia results in IE in patients with a prosthetic valve. Surgery is mandatory in IE with complications and/or caused by particular microorganisms; surgery is essential in most patients with a prosthetic valve. Although the presence of specific links between some procedures and the occurrence of IE has not been clearly proven, a prevention policy is nevertheless justified, considering the morbidity and mortality. Prophylaxis is indicated in patients with the cardiac conditions at risk for IE. IE prophylaxis prevails over prophylactic antibiotics usually administered for surgery.
authors.affiliation: Service d'anesthésie-réanimation 1, CHRU Pontchaillou, Rennes, France.
authors.forename: P
authors.initials: P
authors.lastname: Seguin
authors.forename: Y
authors.initials: Y
authors.lastname: Mallédant
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D016470:Bacteremia / Q000188:drug therapy / Q000517:prevention & control; D004452:Echocardiography; D004697:Endocarditis, Bacterial / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000517:prevention & control / Q000601:surgery; D006331:Heart Diseases / Q000150:complications; D006350:Heart Valve Prosthesis / Q000009:adverse effects; D006801:Humans; D016459:Prosthesis-Related Infections / Q000188:drug therapy / Q000517:prevention & control / Q000601:surgery; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000517:prevention & control; D013290:Streptococcal Infections / Q000188:drug therapy / Q000517:prevention & control; D015996:Survival Rate
chemical_list: D000900:Anti-Bacterial Agents