title: [Langerhans histiocytosis and acute monoblastic leukemia type LMA4].
abstract: BACKGROUND
  Cutaneous manifestations of myelodysplastic syndromes are rare and polymorphous. They can be the direct expression of the hematological disease or represent signs of a vasculitis or a neutrophilic syndrome. Myelodysplastic syndromes progress sometimes toward an acute leukemia.
  
  
  METHODS
  A 53-year-old woman suffering from myelodysplastic syndrome presented for several months a cutaneous vasculitis without any histological specificity. In time, such presentation was complicated by the simultaneous occurrence of a cutaneous Langerhans cell histiocytosis and an acute monoblastic leukemia type LMA 4. The disease was rapidly fatal.
  
  
  CONCLUSIONS
  The complication of a myelodysplastic syndrome by concurrent Langerhans cell histiocytosis and acute monoblastic leukemia suggests a pathogenic relationship between these two latter disorders.
authors.affiliation: Service de Dermatopathologie, Université de Liège.
authors.forename: T
authors.initials: T
authors.lastname: Hermanns-Lê
authors.forename: J E
authors.initials: JE
authors.lastname: Arrese
authors.forename: G E
authors.initials: GE
authors.lastname: Piérard
mesh_terms: D001706:Biopsy; D017809:Fatal Outcome; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000097:blood / Q000145:classification / Q000188:drug therapy / Q000209:etiology*; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000150:complications*; D012871:Skin Diseases / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology