title: Methotrexate treatment in Felty's syndrome.
abstract: Felty's syndrome is a rare disorder characterized as a systemic manifestation of severe rheumatoid arthritis associated with granulocytopenia and splenomegaly. We report a retrospective analysis of a series of seven patients treated successfully with low-dose methotrexate. leading to sustained clinical improvement (number of swollen joints) and normalization of the granulocyte count for an observation period of 1 yr. Our cohort is the largest ever published with methotrexate treatment of this rare condition. Our results confirm earlier single case reports suggesting methotrexate to be the first-choice treatment nowadays in Felty's syndrome.
authors.affiliation: Department of Rheumatology, Evangelisches Fachkrankenhaus, Ratingen, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Wassenberg
authors.forename: G
authors.initials: G
authors.lastname: Herborn
authors.forename: R
authors.initials: R
authors.lastname: Rau
mesh_terms: D000368:Aged; D000380:Agranulocytosis / Q000188:drug therapy*; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use*; D008875:Middle Aged; D012189:Retrospective Studies; D013163:Splenomegaly; D013577:Syndrome
chemical_list: D018501:Antirheumatic Agents; D008727:Methotrexate