Bone morphogenetic proteins--novel regulators of bone formation.
Bone morphogenetic proteins (BMPs), hydrophobic, non-species specific glycoproteins, belong to the expanding transforming growth factor-beta (TGF-beta) superfamily. BMP has pleiotropic function that range from extraskeletal and skeletal organogenesis to bone generation and regeneration. It induces de novo bone formation in post fetal life through the process of direct (intra membranous) and endochondral ossification and their response is dose dependent. Through recombinant gene technology, BMP is available at least in ten forms for basic research and clinical trials. Amino acid sequences and physical properties of BMP family members have been identified. BMP research extends to the fields of developmental biology, genetics and evolution.
Maiti
S K
SK
Division of Surgery, Indian Veterinary Research Institute, Izatnagar, India.
Singh
G R
GR
D000328:Adult; D000595:Amino Acid Sequence; D000818:Animals; D001846:Bone Development / Q000502:physiology; D019485:Bone Morphogenetic Proteins / Q000737:chemistry / Q000502:physiology*; D002648:Child; D006801:Humans; D008969:Molecular Sequence Data
D019485:Bone Morphogenetic Proteins