Familial dysplasminogenemia with central retinal vein and cilioretinal artery occlusion.
OBJECTIVE
To report a 49-year-old woman with unilateral central retinal vein occlusion and ipsilateral cilioretinal artery occlusion who showed familial dysplasminogenemia associated with elevated lipoprotein(a).


METHODS
Case report.


RESULTS
Extensive hemostatic and coagulation studies for causes of thrombosis, as well as family studies, disclosed decreased plasminogen activity without reduction of plasminogen antigen in the patient, her two siblings, and her two children. The patient also showed elevated lipoprotein(a).


CONCLUSIONS
The combination of decreased plasminogen activity and elevated lipoprotein(a) should be considered as a possible cause of retinal vein and artery occlusion.
Iijima
H
H
Department of Ophthalmology, Yamanashi Medical University, Tamaho, Japan. hiijima@res.yamanashi-med.ac.jp
Gohdo
T
T
Tsukahara
S
S
D019842:Ciliary Arteries / Q000473:pathology*; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood; D008875:Middle Aged; D010375:Pedigree; D010958:Plasminogen / Q000172:deficiency* / Q000235:genetics*; D015356:Retinal Artery Occlusion / Q000097:blood / Q000209:etiology* / Q000473:pathology; D012170:Retinal Vein Occlusion / Q000097:blood / Q000209:etiology* / Q000473:pathology
D017270:Lipoprotein(a); D010958:Plasminogen