Utility of routine testing of bronchoalveolar lavage fluid for cryptococcal antigen.
All cryptococcal antigen (CrAg) testing performed at our institution between 1989 and 1994 was reviewed for utility of routinely testing of bronchoalveolar lavage fluid (BAL) for this antigen. Forty-two of 1,506 BAL specimens were positive. Seventeen of these were felt to represent false positives (sensitivity, 71%; positive predictive value, 0.59). The data on CrAg in cerebrospinal fluid and serum and the fungal culture and histological results of BAL specimens did not support continued, routine testing of BALs for CrAg to diagnose cryptococcosis.
Kralovic
S M
SM
Division of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Ohio, USA. Kralovic.Stephen_M@Cincinnati.va.gov
Rhodes
J C
JC
D000946:Antigens, Fungal / Q000032:analysis*; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology*; D003453:Cryptococcosis / Q000175:diagnosis*; D003455:Cryptococcus neoformans / Q000302:isolation & purification*; D003955:Diagnostic Tests, Routine; D005189:False Positive Reactions; D005615:Freezing; D006801:Humans; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013048:Specimen Handling / Q000379:methods; D013997:Time Factors
D000946:Antigens, Fungal