Retroviral vectors for gene therapy.
Although there are many hurdles to overcome for successful gene therapy, there is a vast potential to permanently incorporate genes into cells to correct genetic disorders and to combat viral infections. Retroviruses, inspite of some limitations, offer the best hope in this direction and lentiviral vectors, which infect nondividing cells, may be the choice in the future, especially in gene therapy for central nervous system disorders.
Guntaka
R V
RV
Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri-Columbia 65212, USA. guntaka@showme.missouri.edu
Swamynathan
S K
SK
D000818:Animals; D015316:Genetic Therapy; D005822:Genetic Vectors; D006801:Humans; D012190:Retroviridae / Q000235:genetics*