[The investigation of causes of treatment failures of osteosarcoma].
A series of 57 patients (32 females, 25 males) aged 12-41 (mean 17.2) treated due to IIB advanced osteosarcoma has been analyzed. From among 20 patients who underwent surgery only, 2 persons survived. In 10 patients supplementary chemotherapy or preventive lung radiotherapy has been used. Two patients survived more than 5 years. In past 11 years 4 pre and postoperative chemotherapy protocols have been used. Big number of failures has been noted in the first few years. Despite chemotherapy recurrence took place in 6 cases. Failures resulted also from the late diagnosis or discontinued treatment. During last 5 years all 6 osteosarcoma patients received chemotherapy at Hematology and Pediatric Oncology Department and tumor resection has been performed. All patients stay alive (2 to 5 years).
Mazurkiewicz
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Katedry i Kliniki Ortopedii i Traumatologii AM w Lublinie.
Mazurkiewicz
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M
Warda
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D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000517:prevention & control* / Q000532:radiotherapy; D008297:Male; D012516:Osteosarcoma / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D017211:Treatment Failure