[Interferon-alpha treatment for chemotherapy-resistant primary macroglobulinemia with stomach and lung invasion].
We reported a case of primary macroglobulinemia with stomach and pulmonary invasion. The patient was 71 years-old who had cervical lymphadenopathy and abdominal pain. Biopsy material of cervical lymph node showed non-Hodgkin's lymphoma, and he was diagnosed primary macroglobulinemia by IgM immunological histo-chemical staining of materials of stomach biopsies. Combination chemotherapies were not effective for the reduction of IgM-lambda protein, and organ invasion seemed to be progressive, so we tried interferon-alpha (IFN-alpha) to control M component. Daily injection of 6 megaunits of IFN-alpha induced significant reduction of M component and pulmonary invasion. This favorable changes were observed for 1 year. However, his pulmonary invasion on X-ray films relapsed and he died of respiratory failure by reason of severe pneumonia. IFN-alpha is currently available for myeloproliferative disease, especially chronic myelogenous leukemia and multiple myeloma. This case report showed that IFN-alpha was also available for primary macroglobulinemia.
Kitamura
N
N
First Department of Internal Medicine, Nihon University School of Medicine.
Nishinarita
S
S
Kaneko
M
M
Saito
N
N
Tomita
Y
Y
Sawada
U
U
Sawada
S
S
Horie
T
T
D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use*; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D008168:Lung / Q000473:pathology*; D008297:Male; D013270:Stomach / Q000473:pathology*; D008258:Waldenstrom Macroglobulinemia / Q000188:drug therapy* / Q000473:pathology
D000998:Antiviral Agents; D016898:Interferon-alpha