The effects of histamine H3-receptor antagonists on amygdaloid kindled seizures in rats.
The effects of histamine H3-receptor antagonists, thioperamide, and clobenpropit on amygdaloid kindled seizures were investigated in rats. Both intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) injections of H3-antagonists resulted in a dose-related inhibition of amygdaloid kindled seizures. An inhibition induced by thioperamide was antagonized by an H3-agonist [(R)-alpha-methylhistamine] and H1-antagonists (diphenhydramine and chlorpheniramine). On the other hand, an H2-antagonist (cimetidine and ranitidine) caused no antagonistic effect. Metoprine, an inhibitor of N-methyltransferase was also effective in inhibiting amygdaloid kindled seizure, and this effect was augmented by thioperamide treatment.
Kakinoki
H
H
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Japan.
Ishizawa
K
K
Fukunaga
M
M
Fujii
Y
Y
Kamei
C
C
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006633:Histamine Antagonists / Q000494:pharmacology*; D006637:Histamine N-Methyltransferase / Q000037:antagonists & inhibitors; D007093:Imidazoles / Q000008:administration & dosage / Q000494:pharmacology; D007276:Injections, Intraventricular; D007696:Kindling, Neurologic / Q000502:physiology; D008297:Male; D010880:Piperidines / Q000008:administration & dosage / Q000494:pharmacology; D011739:Pyrimethamine / Q000031:analogs & derivatives / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D018100:Receptors, Histamine H3 / Q000378:metabolism*; D012640:Seizures / Q000503:physiopathology*; D013890:Thiourea / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology
D004791:Enzyme Inhibitors; D006633:Histamine Antagonists; D007093:Imidazoles; D010880:Piperidines; D018100:Receptors, Histamine H3; C006308:metoprine; D006637:Histamine N-Methyltransferase; D013890:Thiourea; C052075:thioperamide; C086108:clobenpropit; D011739:Pyrimethamine