[Primary hyperaldosteronism and adenoma of the adrenal cortex. Suppression of aldosterone with dexamethasone].
The aim of the study was to evaluate dexamethazone test in a patient with primary aldosteronism caused by an adrenocortical adenoma. We observed a 50% decrease of plasma aldosterone as in glucocorticoid suppressible aldosteronism (GSA) but absolute value of aldosterone remained higher than 40 pg/ml. Basal plasma and urinary values of 18 OXO and 18 OH cortisol were not significantly elevated as in GSA. Inversely, the evaluation of 11 beta-hydroxylase activity of mineralocorticoids was in favor of a benign adrenal tumor.
Bercovici
J P
JP
CHU Brest Hôpital Cavale Blanche.
Roudaut
N
N
Kerlan
V
V
Aupetit-Faisant
B
B
Floch
H H
HH
D000236:Adenoma / Q000150:complications*; D000306:Adrenal Cortex Neoplasms / Q000150:complications*; D000450:Aldosterone / Q000097:blood* / Q000652:urine; D003348:Cortisone / Q000031:analogs & derivatives / Q000097:blood; D003907:Dexamethasone / Q000627:therapeutic use*; D006728:Hormones / Q000627:therapeutic use*; D006801:Humans; D006929:Hyperaldosteronism / Q000097:blood / Q000188:drug therapy* / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D008901:Mineralocorticoids / Q000097:blood
D006728:Hormones; D008901:Mineralocorticoids; C044816:18-hydroxycortisone; D000450:Aldosterone; D003907:Dexamethasone; D003348:Cortisone