[Comparison of the analgesic efficacy of EMLA 5% cream and lidocaine infiltration for biopsy of the genital mucosa].
OBJECTIVE
To compare the analgesic efficacy of EMLA 5 p. 100 cream versus Xylocaïne 1 p. 100 infiltration for biopsies of the genital mucosa.


METHODS
63 adult patients were randomized. EMLA (0.3-5 g) was applied during 7-12 minutes, and Xylocaïne 1 p. 100 (0.2-5 ml) was infiltrated 0-10 minutes before biopsy. Pain during the anaesthetic procedure and the biopsy was assessed by the patient using a Visual Analogue Scale.


RESULTS
Pain scores were significantly lower with EMLA application than Xylocaïne infiltration, but infiltration resulted in better surgical anaesthesia. The combined pain scores (anaesthetic procedure and biopsy) were lower in the EMLA group, but this difference failed to reach statistical significance.


CONCLUSIONS
EMLA is a less painful anaesthetic procedure than infiltration, but has a lower analgesic efficacy. EMLA can be used as an alternative to infiltration for biopsies of the genital mucosa.
Drouault
Y
Y
Hôpital Tarnier, Paris.
Guillet
G
G
Morel
P
P
Vilmer
C
C
Benes
G
G
Trinquet
F
F
D000328:Adult; D000368:Aged; D000779:Anesthetics, Local / Q000494:pharmacology*; D001706:Biopsy; D005260:Female; D005835:Genitalia / Q000187:drug effects* / Q000473:pathology; D006801:Humans; D007279:Injections, Subcutaneous; D008012:Lidocaine / Q000494:pharmacology*; D000077442:Lidocaine, Prilocaine Drug Combination; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000187:drug effects; D011318:Prilocaine / Q000494:pharmacology*
D000779:Anesthetics, Local; D000077442:Lidocaine, Prilocaine Drug Combination; D011318:Prilocaine; D008012:Lidocaine