[A study on androgen deprivation therapy prior to radical prostatectomy with special reference to the tumor volume].
BACKGROUND
The aim of this study is to analyze correlation between the tumor volume (TV) and the final pathological stage in patients undergoing neoadjuvant therapy.


METHODS
Twenty-six patients underwent radical prostatectomy alone (group S). The remaining 28 patients had undergone neoadjuvant therapy (group N) which mainly consisted of LH-RH agonist. TV and the final pathological stage were retrospectively reviewed.


RESULTS
The likelihood of positive surgical margin was statistically higher in group S than in group N (p = 0.009). The correlation between TV and the pathological stage was observed not only in group S (rho = 0.646, p = 0.0012) but also in group N (rho = 0.716, p = 0.0002). The mean TV was statistically smaller in group N in patients with baseline PSA level more than 10.1 ng/ml (p = 0.024).


CONCLUSIONS
A decrease in tumor volume caused by neoadjuvant therapy may play an important role in reducing the likelihood of positive surgical margin.
Hachiya
T
T
Department of Urology, Nihon University, School of Medicine.
Nogaki
J
J
Ishida
H
H
Okada
K
K
D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage*; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D020360:Neoadjuvant Therapy; D009361:Neoplasm Invasiveness; D009376:Neoplasms, Hormone-Dependent / Q000473:pathology* / Q000628:therapy*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000628:therapy*
D018931:Antineoplastic Agents, Hormonal; D007987:Gonadotropin-Releasing Hormone