[Prolonged effect of midazolam with delayed postanesthetic recovery from the possible interference of famotidine].
We report the case of a 79-year-old woman, in chronic renal insufficiency who recovered from anaesthesia after a delay of 24 hours, after flumazenil (Anexate) administration. She was given famotidine (Peptidine) the day before surgery. Midazolam was administered for premedication (5 mg per os) and for the induction of anaesthesia (2 mg intravenous). Among the various causes of delayed recovery in this elderly patient, an interaction between midazolam and famotidine is discussed.
Barrau
P
P
Département d'anesthésie réanimation, hôpital G-Montpied, Clermont-Ferrand, France.
Giannelloni
C
C
Gindre
G
G
Bérard
J P
JP
Bazin
J E
JE
D000058:Accidental Falls; D000759:Adjuvants, Anesthesia / Q000009:adverse effects*; D000368:Aged; D000762:Anesthesia Recovery Period; D000768:Anesthesia, General; D004347:Drug Interactions; D015738:Famotidine / Q000009:adverse effects*; D005260:Female; D006635:Histamine H2 Antagonists / Q000009:adverse effects*; D006801:Humans; D006810:Humeral Fractures / Q000601:surgery; D007676:Kidney Failure, Chronic / Q000150:complications; D008874:Midazolam / Q000009:adverse effects*; D011292:Premedication / Q000009:adverse effects*
D000759:Adjuvants, Anesthesia; D006635:Histamine H2 Antagonists; D015738:Famotidine; D008874:Midazolam