title: Amiodarone induced pulmonary fibrosis in infancy.
abstract: We report a case of pulmonary fibrosis in an infant receiving amiodarone for treatment of intractable atrioventricular reentrant tachycardia secondary to Wolff-Parkinson-White syndrome. At 9 months, a screening chest radiograph showed a diffuse interstitial infiltrate in an asymptomatic, thriving infant. Amiodarone was discontinued and the pulmonary fibrosis resolved gradually over 6 months. This case documents the first report of amiodarone induced pulmonary fibrosis in the pediatric age group. We speculate that as amiodarone is used more frequently to manage pediatric arrhythmias, pulmonary fibrosis, a known complication of this antiarrhythmia in adults may be seen with increasing frequency in children.
authors.affiliation: Section of Pediatric Cardiology, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: P N
authors.initials: PN
authors.lastname: Bowers
authors.forename: J
authors.initials: J
authors.lastname: Fields
authors.forename: D
authors.initials: D
authors.lastname: Schwartz
authors.forename: L E
authors.initials: LE
authors.lastname: Rosenfeld
authors.forename: R
authors.initials: R
authors.lastname: Nehgme
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000638:Amiodarone / Q000009:adverse effects*; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D015716:Electrocardiography, Ambulatory; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011433:Propranolol / Q000627:therapeutic use; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000000981:diagnostic imaging; D013902:Radiography, Thoracic; D013617:Tachycardia, Supraventricular / Q000151:congenital / Q000188:drug therapy / Q000503:physiopathology; D014057:Tomography, X-Ray Computed
chemical_list: D000319:Adrenergic beta-Antagonists; D000889:Anti-Arrhythmia Agents; D011433:Propranolol; D000638:Amiodarone