title: Isoniazid-induced crescentic glomerulonephritis in a child with a positive tuberculin skin test.
abstract: Acute nonoliguric renal failure developed in a 13-year-old girl, 1 month after the institution of isoniazid therapy because of a positive tuberculin test at school screening. A renal biopsy demonstrated severe crescentic glomerulonephritis with focal interstitial changes. Discontinuation of isoniazid and a short course of steroids and cyclophosphamide therapy were followed by complete recovery. Whereas isoniazid has been shown to induce a lupus-like syndrome and antihistone antinuclear antibodies, our patient displayed none of the clinical or immunological features that are characteristic of drug-induced lupus. Furthermore, none of the identifiable causes for crescentic glomerulonephritis was evident in this girl. To the best of our knowledge this is the first report suggesting a possible association of crescentic glomerulonephritis to isoniazid treatment.
authors.affiliation: Division of Pediatrics, Rambam Medical Center and Technion, Faculty of Medicine, Haifa, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Brik
authors.forename: D
authors.initials: D
authors.lastname: Magen
authors.forename: O
authors.initials: O
authors.lastname: Ben-Yzhak
authors.forename: J
authors.initials: J
authors.lastname: Grin
mesh_terms: D000293:Adolescent; D000995:Antitubercular Agents / Q000009:adverse effects*; D018450:Disease Progression; D005260:Female; D005921:Glomerulonephritis / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects*; D007668:Kidney / Q000473:pathology; D014374:Tuberculin Test
chemical_list: D000995:Antitubercular Agents; D007538:Isoniazid