[Reevaluation and potential therapeutic effects of estrogen therapy to prostate cancer patients].
Survival time of 65 patients with stage D2 prostate cancer who were treated by estrogen with or without antiplatelet drugs was examined. Survival time of 37 patients with antiplatelet drugs was significantly longer than that of 28 histological control ones. The frequency of death of cardiovascular disease in the former group decreased to 5.3%. Next, progression free time of the 37 patients was compared to the time of 37 patients treated by antiandrogen therapy. The former one was better than the latter. However, survival time after relapse of the estrogen group was shorter than the control. These results suggest that estrogen therapy improved by a combination of antiplatelet drugs has to be reevaluated and contains specific therapeutic effects differing from antiandrogen therapy.
Kato
M
M
Dep. of Urology, Saitama Medical School.
Kase
H
H
Okada
K
K
Tohma
T
T
Ishiwata
D
D
D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D004967:Estrogens / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D009376:Neoplasms, Hormone-Dependent / Q000188:drug therapy* / Q000401:mortality; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000401:mortality; D015996:Survival Rate
D018931:Antineoplastic Agents, Hormonal; D004967:Estrogens; D010975:Platelet Aggregation Inhibitors