Study on interaction of proteins isolated from epithelial cervical tissue with glucocorticoid-response element of HPV16.
Genital HPV16 has tropism to cervical epithelial tissue which is highly steroid hormone dependent. Protein/DNA interaction with the fragment of viral DNA containing the glucocorticoid-response element (GRE/PRE) did not indicate the proteins which can bind to the GRE element in normal epithelial cervical tissue. NFI is one of the cellular factors which can participate in the transcription of viral genes in study tissue.
Poreba
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E
Institute of Molecular Biology and Biotechnology, University of Poznań, Poland.
Goźdicka-Józefiak
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A
Kedzia
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H
D015139:Blotting, Southern; D015153:Blotting, Western; D002584:Cervix Uteri / Q000502:physiology*; D004279:DNA, Viral / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism; D004591:Electrophoresis, Polyacrylamide Gel; D004848:Epithelium / Q000502:physiology; D005260:Female; D006801:Humans; D027383:Papillomaviridae / Q000235:genetics*; D011485:Protein Binding; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D020218:Response Elements / Q000502:physiology
D004279:DNA, Viral; D004268:DNA-Binding Proteins; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone