title: Evaluation of focal cerebral ischemia in rats by magnetic resonance imaging and immunohistochemical analyses.
abstract: Correlation of focal ischemia-induced brain damage evidenced by magnetic resonance imaging (MRI) and by staining with microtubule-associated protein 2 (MAP2) was studied in rats. Ischemia was produced by transient occlusion of the middle cerebral artery (MCAO). The damage was assessed at 6 to 8 hours after MCAO and 1 week later. The area of damage assessed by MRI agreed with that by MAP2 staining at 6 to 8 hours after MCAO, which was smaller (P < 0.001) than that defined by MAP2 staining 1 week after MCAO. Glial staining indicated that glial infiltration affected the signal intensity of MRI in the area of damage.
authors.affiliation: Department of Anesthesia, Kyoto University Hospital, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ishii
authors.forename: T
authors.initials: T
authors.lastname: Arai
authors.forename: S
authors.initials: S
authors.lastname: Morikawa
authors.forename: T
authors.initials: T
authors.lastname: Inubushi
authors.forename: I
authors.initials: I
authors.lastname: Tooyama
authors.forename: H
authors.initials: H
authors.lastname: Kimura
authors.forename: K
authors.initials: K
authors.lastname: Mori
mesh_terms: D000818:Animals; D001157:Arterial Occlusive Diseases / Q000175:diagnosis; D005069:Evaluation Studies as Topic; D006973:Hypertension / Q000473:pathology; D007150:Immunohistochemistry; D002546:Ischemic Attack, Transient / Q000175:diagnosis* / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D008869:Microtubule-Associated Proteins; D051381:Rats; D011918:Rats, Inbred SHR
chemical_list: D008869:Microtubule-Associated Proteins