Nicotinic acetylcholine receptor mediated modulation of evoked excitatory amino acid release in the nucleus tractus solitarius of the rat: evidence from in vivo microdialysis.
In vivo microdialysis was used to measure release of endogenous l-glutamate and l-aspartate in the nucleus tractus solitarius of the anaesthetised rat evoked by baroreceptor loading. Aortic constriction, the method of loading, elicited a reproducible increase in extracellular levels of l-glutamate to 322+/-139% of basal levels, which could be attenuated by concomitant local administration of the nicotinic acetylcholine receptor antagonist mecamylamine (100 microM).
Ashworth-Preece
M A
MA
Department of Pharmacology, Monash University, Wellington Road, Clayton, Victoria 3168, Australia. mark.ashworth-preece@med.monash.edu.au
Jarrott
B
B
Lawrence
A J
AJ
D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism*; D018698:Glutamic Acid / Q000378:metabolism*; D008297:Male; D008464:Mecamylamine / Q000494:pharmacology; D017551:Microdialysis; D018733:Nicotinic Antagonists / Q000494:pharmacology; D011311:Pressoreceptors / Q000502:physiology; D051381:Rats; D011921:Rats, Inbred WKY; D011978:Receptors, Nicotinic / Q000502:physiology*; D017552:Solitary Nucleus / Q000378:metabolism*
D018733:Nicotinic Antagonists; D011978:Receptors, Nicotinic; D001224:Aspartic Acid; D018698:Glutamic Acid; D008464:Mecamylamine