title: Jarisch-Herxheimer reaction complicating the treatment of chronic Q fever endocarditis: elevated TNFalpha and IL-6 serum levels.
abstract: Jarisch-Herxheimer reaction (J-HR) is an acute febrile reaction which may complicate the initiation of an effective treatment against infections due to intracellular micro-organisms. We report a case of J-HR complicating treatment of chronic Q fever endocarditis with demonstration of elevated serum cytokine concentrations.
authors.affiliation: Service de Médicine Interne, INSERM U387, Hôpital Sainte-Marguerite, Marseille, France.
authors.forename: G
authors.initials: G
authors.lastname: Kaplanski
authors.forename: B
authors.initials: B
authors.lastname: Granel
authors.forename: T
authors.initials: T
authors.lastname: Vaz
authors.forename: J M
authors.initials: JM
authors.lastname: Durand
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000009:adverse effects / Q000627:therapeutic use; D002908:Chronic Disease; D016997:Coxiella burnetii / Q000302:isolation & purification*; D004318:Doxycycline / Q000009:adverse effects / Q000627:therapeutic use; D004342:Drug Hypersensitivity; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin / Q000009:adverse effects / Q000627:therapeutic use; D011778:Q Fever / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D015242:Ofloxacin; D004318:Doxycycline