title: Upbeat nystagmus: clinicoanatomical correlation.
abstract: A patient is reported on with isolated upbeating nystagmus with a linear slow phase in whom a solitary lesion, probably inflammatory, was detected radiologically in the dorsal paramedian caudal medulla, encompassing the most caudal of the perihypoglossal nuclei, the nucleus intercalatus of Staderini. The conjunction of a vestibular pattern of nystagmus with this focal lesion runs contrary to a previous suggestion that the nucleus intercalatus may act as a neural integrator for vertical conjugate eye movements.
authors.affiliation: Department of Neurology, St Mary's Hospital, London, UK.
authors.forename: J C
authors.initials: JC
authors.lastname: Janssen
authors.forename: A J
authors.initials: AJ
authors.lastname: Larner
authors.forename: H
authors.initials: H
authors.lastname: Morris
authors.forename: A M
authors.initials: AM
authors.lastname: Bronstein
authors.forename: S F
authors.initials: SF
authors.lastname: Farmer
mesh_terms: D000328:Adult; D001927:Brain Diseases / Q000175:diagnosis* / Q000503:physiopathology; D001931:Brain Mapping; D003937:Diagnosis, Differential; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008526:Medulla Oblongata / Q000473:pathology / Q000503:physiopathology*; D009430:Neural Analyzers / Q000503:physiopathology; D009759:Nystagmus, Pathologic / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology