Reevaluation of antipyretics in children with enteric fever.
BACKGROUND
The Committee on Infectious Diseases of the American Academy of Pediatrics recommends withholding antipyretic administration to patients with enteric fever because of the risk of shock developing as a consequence.


OBJECTIVE
To evaluate the effects of antipyretics on blood pressure in children with enteric fever.


METHODS
A retrospective review of medical records of patients admitted to Texas Children's Hospital from January, 1977, to October, 1997, with a diagnosis of enteric fever. All febrile episodes were evaluated for the use of antipyretics and evidence of hypotension or cardiovascular decompensation associated with them.


RESULTS
Twenty-nine patients with enteric fever were identified. Salmonella typhi caused 23 of these infections. Antipyretics were used in all but one patient. We did not find any association between the use of antipyretics and the development of hypotension. One patient developed shock and adult respiratory distress syndrome >36 h after start of antibiotic therapy and unrelated to fever or antipyretic use. Two patients had evidence of dehydration. No other complications occurred.


CONCLUSIONS
We did not find any complications associated with the use of acetaminophen or ibuprofen in children with enteric fever. The effects of antipyretics in enteric fever should be further studied.
Noyola
D E
DE
Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, USA.
Fernandez
M
M
Kaplan
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SL
D000082:Acetaminophen / Q000009:adverse effects / Q000627:therapeutic use*; D000293:Adolescent; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects / Q000627:therapeutic use*; D001794:Blood Pressure; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007022:Hypotension; D007052:Ibuprofen / Q000009:adverse effects / Q000627:therapeutic use*; D007223:Infant; D008297:Male; D012189:Retrospective Studies; D014435:Typhoid Fever / Q000188:drug therapy* / Q000382:microbiology
D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen; D007052:Ibuprofen