Lack of retrovirus gene expression in teratocarcinoma stem cells is limited to the nucleus.
Experiments are described showing that the block to retrovirus replication by undifferentiated embryonal carcinoma cells can be overcome by fusion with differentiated cell karyoplasts but not cytoplasts. This supports previous notions that the expression of input proviral genes in teratocarcinoma stem cells is under different controls than in differentiated cells and indicates that the exercising of this control is limited to the nucleus of the embryonal carcinoma cell.
Gautsch
J W
JW
Department of Immunopathology, Research Institute of Scripps Clinic, La Jolla, California 92037, USA.
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D002467:Cell Nucleus / Q000235:genetics; D054278:Embryonal Carcinoma Stem Cells; D015972:Gene Expression Regulation, Neoplastic; D015967:Gene Expression Regulation, Viral; D005814:Genes, Viral / Q000502:physiology; D009052:Leukemia Virus, Murine / Q000235:genetics* / Q000254:growth & development; D007942:Leukemia, Experimental / Q000235:genetics*; D051379:Mice; D014411:Neoplastic Stem Cells / Q000502:physiology / Q000821:virology*; D012192:Retroviridae Infections / Q000235:genetics*; D018243:Teratocarcinoma; D014412:Tumor Virus Infections / Q000235:genetics*