No heroin or morphine 6beta-glucuronide analgesia in mu-opioid receptor knockout mice.
Recent reports suggest that heroin and its metabolite morphine 6beta-glucuronide can produce analgesia independent of the morphine-preferring mu-opioid receptor. We have tested heroin and morphine 6beta-glucuronide analgesia in wild-type, homozygous and heterozygous mu-opioid receptor knockout mice. Homozygotes display no heroin or morphine 6beta-glucuronide analgesia. Heterozygous mice with one mu-opioid receptor gene copy reveal reduced heroin and morphine 6beta-glucuronide analgesia. The mu-opioid receptor-dependence of heroin and morphine 6beta-glucuronide fails to support a requirement for a heroin-specific opiate receptor subtype.
Kitanaka
N
N
Molecular Neurobiology Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD 21224, USA.
Sora
I
I
Kinsey
S
S
Zeng
Z
Z
Uhl
G R
GR
D000698:Analgesia; D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D003932:Heroin / Q000494:pharmacology*; D006720:Homozygote; D051379:Mice; D018345:Mice, Knockout; D009022:Morphine Derivatives / Q000494:pharmacology*; D017450:Receptors, Opioid, mu / Q000187:drug effects* / Q000378:metabolism
D000701:Analgesics, Opioid; D009022:Morphine Derivatives; D017450:Receptors, Opioid, mu; C035349:morphine-6-glucuronide; D003932:Heroin