title: [Exclusive use of calcium channel blockers and cardioselective beta-blockers in the pre- and per-operative management of pheochromocytomas. 70 cases].
abstract: The pre and intraoperative use of calcium channel blockers (CCB) has been suggested for the management of either eutopic or ectopic pheochromocytomas. We report our experience of 70 pheochromocytomas, operated between 1988 and 1996 and managed with CCB, especially nicardipine. 59 were hypertensive (84.2%). Preparation consisted of nicardipine in 61 patients or another CCB in 9 cases with duration ranging from 24 hours to several weeks depending on plasma volume and blood pressure control. Intraoperatively, nicardipine infusion was started after intubation, adjusted according to systolic blood pressure (SBP) and stopped before ligation of the tumor venous drainage. Increases in SBP greater than 200 mmHg were observed in 10 patients and were effectively controlled by nicardipine in all cases. In 16 patients, the S > BP remained less than 150 mmHg throughout anesthesia. Heart rate greater than 100 b p m occureed in 51 patients and was easily controlled with esmolol whenever used (n = 27). Arythmias were unfrequent (n = 4) and required treatment in only one case. This study confirms the ability to adequately manage pheochromocytomas with the use of nicardipine as sole vasodilating agent.
authors.affiliation: Service de Chirurgie Générale et Endocrinienne, Hôpital Huriez, Centre Hospitalier Universitaiŕe de Lille.
authors.forename: F
authors.initials: F
authors.lastname: Combemale
authors.forename: B
authors.initials: B
authors.lastname: Carnaille
authors.forename: B
authors.initials: B
authors.lastname: Tavernier
authors.forename: M B
authors.initials: MB
authors.lastname: Hautier
authors.forename: A
authors.initials: A
authors.lastname: Thevenot
authors.forename: P
authors.initials: P
authors.lastname: Scherpereel
authors.forename: C
authors.initials: C
authors.lastname: Proye
mesh_terms: D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000150:complications / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002648:Child; D016903:Drug Monitoring; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology; D007430:Intraoperative Care / Q000379:methods*; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D009529:Nicardipine / Q000627:therapeutic use*; D010673:Pheochromocytoma / Q000150:complications / Q000601:surgery*; D011300:Preoperative Care / Q000379:methods*
chemical_list: D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D009529:Nicardipine