title: Randomized double-blind placebo-controlled multicenter evaluation of efficacy and dose finding of midodrine hydrochloride in women with mild to moderate stress urinary incontinence: a phase II study.
abstract: Midodrine is a potent and selective alpha1-receptor agonist and its potential to increase urethral closure pressure could be useful in the treatment of female stress incontinence. The aim of this randomized double-blind placebo-controlled multicenter study was to evaluate the efficacy and safety of midodrine for the treatment of stress urinary incontinence. The primary criterion of efficacy was the maximum urethral closure pressure at rest. Voiding diaries, symptom and incontinence questionnaires and patient/investigator global assessment were also used to evaluate its efficacy. After 4 weeks of treatment no significant changes in MUCP were found. The global assessment by the patient and investigator did indicate that patients on active treatment had a more positive assessment than the placebo group. In conclusion, midodrine did not cause significant improvements in urodynamic parameters, but there were subjective improvements in some of the patients in the treated groups. Furthermore midodrine was well tolerated.
authors.affiliation: University Hospital Maastricht, The Netherlands.
authors.forename: E H
authors.initials: EH
authors.lastname: Weil
authors.forename: P H
authors.initials: PH
authors.lastname: Eerdmans
authors.forename: G A
authors.initials: GA
authors.lastname: Dijkman
authors.forename: K
authors.initials: K
authors.lastname: Tamussino
authors.forename: J
authors.initials: J
authors.lastname: Feyereisl
authors.forename: M E
authors.initials: ME
authors.lastname: Vierhout
authors.forename: C
authors.initials: C
authors.lastname: Schmidbauer
authors.forename: C
authors.initials: C
authors.lastname: Egarter
authors.forename: D
authors.initials: D
authors.lastname: Kölle
authors.forename: J E
authors.initials: JE
authors.lastname: Plasman
authors.forename: H
authors.initials: H
authors.lastname: Heidler
authors.forename: B E
authors.initials: BE
authors.lastname: Abbühl
authors.forename: W
authors.initials: W
authors.lastname: Wein
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage* / Q000009:adverse effects; D000328:Adult; D000368:Aged; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008875:Middle Aged; D008879:Midodrine / Q000008:administration & dosage* / Q000009:adverse effects; D016896:Treatment Outcome; D014521:Urethra / Q000187:drug effects; D014550:Urinary Incontinence, Stress / Q000188:drug therapy* / Q000209:etiology; D014563:Urodynamics / Q000187:drug effects
chemical_list: D000316:Adrenergic alpha-Agonists; D008879:Midodrine