Amlodipine overdose causes prolonged calcium channel blocker toxicity.
Amlodipine is a relatively new agent that has the longest half-life of all calcium channel blockers. This report describes a severe overdose that resulted in prolonged and severe hemodynamic compromise for up to 10 days, but responded to aggressive therapy with calcium, glucagon, and other vasoactive medicines.
Adams
B D
BD
Department of Internal Medicine, Dwight D. Eisenhower Army Medical Center, Fort Gordon, GA 30905, USA.
Browne
W T
WT
D000368:Aged; D017311:Amlodipine / Q000506:poisoning*; D002121:Calcium Channel Blockers / Q000506:poisoning*; D062787:Drug Overdose; D004638:Emergency Treatment; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male
D002121:Calcium Channel Blockers; D017311:Amlodipine