title: Timing of postprandial dyspeptic symptoms and transpyloric passage of gastric contents.
abstract: BACKGROUND
  Patients with functional dyspepsia often experience early satiety and discomfort after a meal. The role of early gastric emptying in symptom generation is not known. Our aim was to relate timing of symptoms and early postprandial emptying in functional dyspepsia.
  
  
  METHODS
  Twelve patients with functional dyspepsia were investigated during 3 min of fasting, during 3 min of ingesting 500 ml of a meat soup, and during the first 10 min postprandially by means of duplex sonography.
  
  
  RESULTS
  Gastric emptying commenced on average 52 sec after the start of ingestion. Transpyloric movements of gastric contents unrelated to peristalsis (that is, alternating transpyloric emptying and reflux within a common chamber created by the terminal antrum, the pylorus, and the duodenal bulb) appeared before peristaltic-related emptying, which commenced after on average 116 sec. In all patients epigastric, meal-related discomfort was experienced after the commencement of transpyloric emptying, on average after 143 sec. A negative correlation was found between intensity of fullness and duration of presymptomatic transpyloric movements of gastric contents (that is, the duodenal 'tasting' period).
  
  
  CONCLUSIONS
  The early occurrence of meal-related symptoms suggests that gastric distension is the main factor in symptom generation. However, the onset of symptoms after the commencement of gastric emptying suggests that intestinal tasting receptors are involved in symptom generation. The inverse relationship between the duration of the tasting period and symptom intensity suggests that the time allowed for duodenal tasting might be too short in patients with FD.
authors.affiliation: Division of Gastroenterology, Medical Dept. A, Haukeland University Hospital, Bergen, Norway.
authors.forename: T
authors.initials: T
authors.lastname: Hausken
authors.forename: O H
authors.initials: OH
authors.lastname: Gilja
authors.forename: K A
authors.initials: KA
authors.lastname: Undeland
authors.forename: A
authors.initials: A
authors.lastname: Berstad
mesh_terms: D000328:Adult; D004415:Dyspepsia / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D005746:Gastric Emptying; D005773:Gastroscopy; D006801:Humans; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D013997:Time Factors; D018608:Ultrasonography, Doppler