Syntheses of some 4-[(4-chloro-5-methyl-2-methylthiophenyl)sulphonyl]-1-(aryl)semicarbazi des and N-[(4-chloro-5-methyl-2-methylthiophenyl)sulphonyl]-N'-(4-chlorophenyl) urea with potential anticancer activity.
A series of 4-[(4-chloro-5-methyl-2-methylthiophenyl) sulphonyl]-1-(aryl)semicarbazides [IV-XI] and N-[(4-chloro-5-methylthiophenyl)sulphonyl]-N'-(4-chlorophenyl)urea [XII] were prepared and evaluated in vitro for anticancer activity [IV-VII, IX-XII]. All compounds exhibited weak [V-VII, IX] or moderate [IV, X-XII] activity against some human tumor cell lines, whereas the compound [XII] showed a relatively high activity (Table 3).
Brzozowski
Z
Z
Department of Chemical Drug Technology, Medical University, Gdańsk, Poland.
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D012663:Semicarbazides / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
C114763:4-((4-chloro-5-methyl-2-methylthiophenyl)sulphonyl)-N-(chlorophenyl)urea; D000970:Antineoplastic Agents; D012663:Semicarbazides; D014508:Urea