Natural history of SIVmac BK28 and H824 infection in Macaca nemestrina.
The natural histories of disease progression induced by two closely related molecular clones of SIVmac were evaluated to determine the utility of these viruses for modeling fast and slow progression to AIDS in Macaca nemestrina. Viral and immune parameters were measured to determine differential progression. Survival time, viral load and CD4+ T cell decline all were indicative of distinct rates of progression, while early measurements of interferon-gamma (IFNgamma) producing cells did not indicate significant differences.
Mulvania
T
T
Department of Microbiology, University of Washington, Seattle 98195-7740, USA. mulvania@u.washington.edu
Coon
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Kuller
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L
Agy
M B
MB
Morton
W R
WR
Mullins
J I
JI
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D000917:Antibody Formation; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D016207:Cytokines / Q000096:biosynthesis; D018450:Disease Progression; D008254:Macaca nemestrina; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000503:physiopathology*; D015302:Simian Immunodeficiency Virus / Q000145:classification* / Q000302:isolation & purification / Q000502:physiology; D016019:Survival Analysis; D013997:Time Factors
D000914:Antibodies, Viral; D016207:Cytokines