[Fas, fas ligand, immune tolerance, and cancer: implications in cancer of the colon].
Fas and Fas ligand (FasL) are implicated in programmed cell death or apoptosis. In the immunological field, they are particularly important in auto-immunity, graft rejection and anti-tumoral response. Fas ligand expression on thymocytes, activated T lymphocytes, and in sites of immune privilege, suggests the importance of Fas/FasL interactions in negative control of the immune response. The recent description of FasL expression by tumoral cells, represents a new mechanism of immune escape for different cancer, and has been well studied in colon adenocarcinoma.
Berger
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A
Service de chirurgie générale, digestive et oncologique, Hôpital Laennec, Paris.
Piqueras
B
B
Pages
F
F
Tartour
E
E
Cugnenc
P H
PH
Fridman
W H
WH
D017209:Apoptosis / Q000235:genetics / Q000502:physiology*; D003110:Colonic Neoplasms / Q000276:immunology* / Q000378:metabolism; D053938:DNA Fragmentation; D053222:Fas Ligand Protein; D006801:Humans; D007108:Immune Tolerance; D007111:Immunity, Cellular; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology; D008562:Membrane Glycoproteins / Q000276:immunology / Q000502:physiology*; D014181:Transplantation Immunology; D019014:fas Receptor / Q000276:immunology / Q000502:physiology*
C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; D019014:fas Receptor