title: Rothmund-Thomson syndrome and tolerance of chemoradiotherapy.
abstract: Rothmund-Thomson syndrome (RTS) is a rare disorder with a predisposition for cutaneous and non-cutaneous malignancy. It is speculated that ultraviolet (UV) sensitivity and deficient DNA repair may account for this predisposition and influence the tolerance of chemoradiotherapeutic management. A case is reported of the management of an RTS patient with squamous cell carcinoma of the tongue who demonstrated increased radiosensitivity and tissue intolerance to chemotherapy.
authors.affiliation: Royal Adelaide Hospital Cancer Centre, Royal Adelaide Hospital, Australia.
authors.forename: M F
authors.initials: MF
authors.lastname: Borg
authors.forename: I N
authors.initials: IN
authors.lastname: Olver
authors.forename: M P
authors.initials: MP
authors.lastname: Hill
mesh_terms: D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects* / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000188:drug therapy* / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D011882:Radiotherapy, High-Energy / Q000009:adverse effects*; D011038:Rothmund-Thomson Syndrome / Q000150:complications*; D014062:Tongue Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000532:radiotherapy*
chemical_list: D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate