title: Massive lymphocytic infiltration of uterine leiomyomas associated with GnRH agonist treatment.
abstract: OBJECTIVE
  To report two unusual cases of massive lymphocytic infiltration of uterine leiomyomas, following GnRH agonist treatment. Previous reports have described a variety of alterations in leiomyoma histology following such therapy.
  
  
  RESULTS
  These cases were studied using haematoxylin and eosin stains, and immunohistochemistry for B and T-cell markers (CD20/CD79a and CD3/UCHL-1) was performed. Leiomyomas were heavily infiltrated predominantly by mature lymphocytes of T-cell phenotype. Associated myocyte degenerative changes were present.
  
  
  CONCLUSIONS
  Massive lymphocytic infiltration of leiomyomas may occur as a result of GnRH agonist treatment, although the mechanism is unclear.
authors.affiliation: Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: V
authors.initials: V
authors.lastname: Bardsley
authors.forename: P
authors.initials: P
authors.lastname: Cooper
authors.forename: D S
authors.initials: DS
authors.lastname: Peat
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D017273:Goserelin / Q000627:therapeutic use; D006801:Humans; D007889:Leiomyoma / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D008214:Lymphocytes / Q000276:immunology*; D008875:Middle Aged; D014594:Uterine Neoplasms / Q000276:immunology* / Q000473:pathology / Q000628:therapy
chemical_list: D018931:Antineoplastic Agents, Hormonal; D017273:Goserelin