Sex-restricted non-Mendelian inheritance of mouse chromosome 11 in the offspring of crosses between C57BL/6J and (C57BL/6J x DBA/2J)F1 mice.
We report on the observation of sex-restricted, non-Mendelian inheritance over a region of mouse Chromosome (Chr) 11, occurring in the offspring of crosses between two commonly used Mus musculus-derived inbred strains, C57BL/6J and DBA/2J. In the surviving backcross progeny of reciprocal matings between (C57BL/6J x DBA/2J)F1 hybrids and the C57BL/6J parental strain, we observed the preferential appearance of C57BL/6J alleles along a region of Chr 11. The deviation from Mendelian predictions was observed only in female offspring from both reciprocal backcrosses, and not in males from either cross. The sex-specificity of the observed non-Mendelian inheritance points to an explanation based on embryonic or neonatal lethality. Our data add to previously obtained evidence for a Chr 11 locus or loci with sex-specific and allele-specific effects on viability.
Shendure
J
J
Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544-1014, USA.
Melo
J A
JA
Pociask
K
K
Derr
R
R
Silver
L M
LM
D000483:Alleles; D000818:Animals; D002875:Chromosomes / Q000235:genetics*; D003433:Crosses, Genetic; D005260:Female; D005313:Fetal Death / Q000235:genetics; D005838:Genotype; D006579:Heterozygote; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D010641:Phenotype; D011247:Pregnancy; D012727:Sex Characteristics