Effect of niacin supplementation on fibrinogen levels in patients with peripheral vascular disease.
This study demonstrates that niacin supplementation decreases plasma fibrinogen and low-density lipoprotein cholesterol in subjects with peripheral vascular disease randomized to receive niacin, warfarin, antioxidants, or placebo. Changes in fibrinogen levels are highly correlated with changes in low-density lipoprotein cholesterol (r = 0.61; p < 0.009) in subjects taking niacin.
Philipp
C S
CS
Department of Medicine, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903-0019, USA.
Cisar
L A
LA
Saidi
P
P
Kostis
J B
JB
D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage; D001157:Arterial Occlusive Diseases / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D000960:Hypolipidemic Agents / Q000008:administration & dosage*; D007511:Ischemia / Q000097:blood; D007866:Leg / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D009525:Niacin / Q000008:administration & dosage*; D014859:Warfarin / Q000008:administration & dosage
D000975:Antioxidants; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D000960:Hypolipidemic Agents; D009525:Niacin; D014859:Warfarin; D005340:Fibrinogen