Oral pharmacological treatments for parasitic diseases of rainbow trout Oncorhynchus mykiss. II. Gyrodactylus sp.
A total of 24 drugs were evaluated as regards their efficacy for oral treatment of gyrodactylosis in rainbow trout Oncorhynchus mykiss. In preliminary trials, all drugs were supplied to infected fish at 40 g per kg of feed for 10 d. Twenty-two of the drugs tested (aminosidine, amprolium, benznidazole, bithionol, chloroquine, diethylcarbamazine, flubendazole, levamisole, mebendazole, metronidazole, niclosamide, nitroxynil, oxibendazole, parbendazole, piperazine, praziquantel, ronidazole, secnidazole, tetramisole, thiophanate, toltrazuril and trichlorfon) were ineffective. Triclabendazole and nitroscanate completely eliminated the infection. Triclabendazole was effective only at the screening dosage (40 g per kg of feed for 10 d), while nitroscanate was effective at dosages as low as 0.6 g per kg of feed for 1 d.
Tojo
J L
JL
Department of Microbiology and Parasitology, Faculty of Pharmacy, Universidad de Santiago de Compostela, Spain. mpmatesa@usc.es
Santamarina
M T
MT
D000284:Administration, Oral; D000821:Animal Feed; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000008:administration & dosage / Q000627:therapeutic use; D002590:Cestode Infections / Q000188:drug therapy / Q000662:veterinary*; D005393:Fish Diseases / Q000188:drug therapy*; D017686:Oncorhynchus mykiss / Q000469:parasitology*; D010647:Phenyl Ethers / Q000008:administration & dosage / Q000627:therapeutic use; D013861:Thiocyanates / Q000008:administration & dosage / Q000627:therapeutic use; D000077682:Triclabendazole
D000871:Anthelmintics; D001562:Benzimidazoles; D010647:Phenyl Ethers; D013861:Thiocyanates; D000077682:Triclabendazole; C011042:nitroscanate