Distribution and functional diversification of the ras superfamily in Saccharomyces cerevisiae.
The recent availability of the full Saccharomyces cerevisiae genome sequence offers a first opportunity to analyze the composition, function and evolution of GTPases in the ras-p21 superfamily. This superfamily in yeast is composed of 29 proteins divided into five families: ras with four sequences implicated in cell signalling; rho, six genes related to the cell shape machinery; ypt-rab, ten proteins with different roles in intracellular trafficking; arf-sar, seven proteins related to vesicular trafficking in secretory pathways; and ran, two proteins acting as components of the nuclear transport system. The superfamily covers a wide range of cellular functions from signalling to intracellular trafficking, while conserving the structural framework and a common mechanism of GTP hydrolysis.
Garcia-Ranea
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JA
Protein Design Group, CNB-CSIC, Cantoblanco, Madrid, Spain. ranea@cnb.uam.es
Valencia
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A
D019143:Evolution, Molecular; D020558:GTP Phosphohydrolases / Q000235:genetics; D016681:Genome, Fungal; D006801:Humans; D015689:Oncogene Protein p21(ras) / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D012568:Schizosaccharomyces / Q000235:genetics
D020558:GTP Phosphohydrolases; D015689:Oncogene Protein p21(ras)