Massive lymphocytic infiltration of uterine leiomyomas associated with GnRH agonist treatment.
OBJECTIVE
To report two unusual cases of massive lymphocytic infiltration of uterine leiomyomas, following GnRH agonist treatment. Previous reports have described a variety of alterations in leiomyoma histology following such therapy.


RESULTS
These cases were studied using haematoxylin and eosin stains, and immunohistochemistry for B and T-cell markers (CD20/CD79a and CD3/UCHL-1) was performed. Leiomyomas were heavily infiltrated predominantly by mature lymphocytes of T-cell phenotype. Associated myocyte degenerative changes were present.


CONCLUSIONS
Massive lymphocytic infiltration of leiomyomas may occur as a result of GnRH agonist treatment, although the mechanism is unclear.
Bardsley
V
V
Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK.
Cooper
P
P
Peat
D S
DS
D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D017273:Goserelin / Q000627:therapeutic use; D006801:Humans; D007889:Leiomyoma / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D008214:Lymphocytes / Q000276:immunology*; D008875:Middle Aged; D014594:Uterine Neoplasms / Q000276:immunology* / Q000473:pathology / Q000628:therapy
D018931:Antineoplastic Agents, Hormonal; D017273:Goserelin