Radiochemical purification of no-carrier-added scandium-47 for radioimmunotherapy.
A procedure, adaptable to large-scale remote operation, was developed to purify no-carrier-added (NCA) 47Sc from irradiated Ti targets. Methods based on extraction chromatography and cation-exchange chromatography were compared. Results of this comparison led to the development of an optimized procedure based on cation-exchange with Dowex AG 50W-X4 and 47Sc elution with HCl/HF. This method gave 90-97% overall 47Sc recovery, with a Ti separation factor greater than 2.4 x 10(-5), and specific activities > or = 0.9 GBq microgram-1. Use of the 47Sc product, for labeling monoclonal antibodies, resulted in consistent labeling yields of > or = 90%.
Kolsky
K L
KL
Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA.
Joshi
V
V
Mausner
L F
LF
Srivastava
S C
SC
D002852:Chromatography, Ion Exchange; D007202:Indicators and Reagents; D016499:Radioimmunotherapy; D011868:Radioisotopes / Q000302:isolation & purification*; D019275:Radiopharmaceuticals / Q000627:therapeutic use; D012538:Scandium / Q000302:isolation & purification* / Q000627:therapeutic use
D007202:Indicators and Reagents; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D012538:Scandium