Bioaccumulation of musk xylene (MX) in developing and adult rats of both sexes.
Bioaccumulation of musk xylene (MX) was measured by GC-ECD in adult and developing Long Evans rats. Males and females were fed with MX-containing chow (0.001, 0.01, 0.033, 0.1 g MX/kg food pellets) for 10 weeks before mating. Treatment continued during pregnancy and lactation. Offspring exhibited dose-dependent MX accumulation with 1/2-3/4 of adult female or 3-4 times adult male body fat levels (at 0.1 mg/kg food) at days 1 and 14. Milk levels were comparable to adult female adipose tissue. Data indicate significant transplacental passage and exposure via maternal milk. In rats fed with MX in adulthood, levels were highest in adipose tissue with significant amounts in other organs (ovary, adrenal). Female tissue levels were 3.7-6.8 times higher. This unexplained sex difference was unrelated to lipid content and was absent in offspring.
Suter-Eichenbeger
R
R
Institute of Pharmacology, University of Zürich, Switzerland.
Altorfer
H
H
Lichtensteiger
W
W
Schlumpf
M
M
D000273:Adipose Tissue / Q000378:metabolism; D000821:Animal Feed; D000818:Animals; D000831:Animals, Newborn; D002849:Chromatography, Gas; D005260:Female; D007774:Lactation; D008297:Male; D008431:Maternal-Fetal Exchange; D008892:Milk / Q000737:chemistry; D011247:Pregnancy; D051381:Rats; D012737:Sex Factors; D014018:Tissue Distribution; D014874:Water Pollutants, Chemical / Q000378:metabolism* / Q000493:pharmacokinetics; D014992:Xylenes / Q000378:metabolism* / Q000493:pharmacokinetics
D014874:Water Pollutants, Chemical; D014992:Xylenes; C031447:musk xylene