title: The quantity of dietary protein affects brain protein synthesis rate in aged rats.
abstract: The purpose of this study was to determine whether the quantity of dietary protein affects the rate of brain protein synthesis in aged rats. Experiments were conducted on three groups of 30-wk-old rats fed diets containing 0, 5 or 20 g casein/100 g for 10 d. The fractional rates of protein synthesis in brain, liver and kidney declined with a decrease in quantity of dietary protein. In brain, liver and kidney, RNA activity [g protein synthesized/(g RNA.d)] was significantly correlated with the fractional rate of protein synthesis. The RNA concentration (mg RNA/g protein) was not related to the fractional rate of protein synthesis in any organ. The results suggest that the rate of protein synthesis in the brain declines with a decrease in quantity of dietary protein in aged rats, and that RNA activity is at least partly related to the fractional rate of brain protein synthesis.
authors.affiliation: Department of Home Economics, Aichi University of Education, Kariya, Aichi 448-8542, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Hayase
authors.forename: M
authors.initials: M
authors.lastname: Koie
authors.forename: H
authors.initials: H
authors.lastname: Yokogoshi
mesh_terms: D000375:Aging / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001835:Body Weight; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002364:Caseins / Q000494:pharmacology; D004044:Dietary Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009929:Organ Size; D014176:Protein Biosynthesis; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002364:Caseins; D004044:Dietary Proteins