Early localization of mRNA coding for 5-HT1A receptors in human brain during development.
The distribution of 5-HT1A receptor mRNA in the human brain was studied in neonatal, children and adult cases by means of in situ hybridization histochemistry, using an oligonucleotide derived from the coding region of the human receptor. A prenatal pattern of development was observed. The hippocampus, raphe nuclei and neocortex presented high levels of hybridization already at the fetal/neonatal stage, fully comparable to the adult. A high and transient hybridization signal was found in cerebellum. These results support a role for 5-HT1A receptors in the regulation of neural development.
del Olmo
E
E
Department of Physiology and Pharmacology, Unit of Pharmacology, Facultad de Medicina, Universidad de Cantabria, Avda Herrera Oria s/n, 39011, Santander, Spain.
López-Giménez
J F
JF
Vilaró
M T
MT
Mengod
G
G
Palacios
J M
JM
Pazos
A
A
D001921:Brain / Q000254:growth & development* / Q000502:physiology; D001923:Brain Chemistry / Q000502:physiology*; D002531:Cerebellum / Q000737:chemistry / Q000254:growth & development; D002648:Child; D002675:Child, Preschool; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006624:Hippocampus / Q000737:chemistry / Q000254:growth & development; D006801:Humans; D017403:In Situ Hybridization; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D015345:Oligonucleotide Probes; D012333:RNA, Messenger / Q000032:analysis; D011903:Raphe Nuclei / Q000737:chemistry / Q000254:growth & development; D011985:Receptors, Serotonin / Q000235:genetics*; D044263:Receptors, Serotonin, 5-HT1
D015345:Oligonucleotide Probes; D012333:RNA, Messenger; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1