[Experimental research on the ultrastructural changes in the cells of the spiral organ].
Adverse effects of vibration and kanamycin on the spiral organ (SO), SO response to physiotherapeutic electrostimulation and ceruloplasmin were studied in guinea pigs. Vibration and kanamycin provoked the same reaction of the SO receptor cells which can be characterized as metabolic stress. In this case mitochondria suffer most of all. Electrostimulation and administration of protein-antioxidant ceruloplasmin gave rise to protective changes suggesting activation of biosynthetic and energetic processes in the receptor cells.
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D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D002570:Ceruloplasmin / Q000494:pharmacology; D004558:Electric Stimulation; D006168:Guinea Pigs; D007612:Kanamycin / Q000494:pharmacology; D008854:Microscopy, Electron; D009925:Organ of Corti / Q000187:drug effects / Q000648:ultrastructure*; D013997:Time Factors; D014732:Vibration / Q000009:adverse effects
D000900:Anti-Bacterial Agents; D000975:Antioxidants; D007612:Kanamycin; D002570:Ceruloplasmin