title: Oxidative stress in subjects affected by celiac disease.
abstract: In order to study the role of oxidative stress in celiac disease, protein carbonyl groups, thiobarbituric acid-reactive substance and pentosidine were evaluated in the plasma of nine patients with asymptomatic celiac disease and in a control group (n = 25). Plasma alpha-tocopherol, retinol and lipids were determined in the same samples. The levels of markers of oxidative stress derived from both protein (carbonyl groups) and lipids (thiobarbituric acid-reactive substances) were significantly higher in celiac disease patients, whereas lipoproteins and alpha-tocopherol were significantly lower. These data indicate that in celiac disease, even when asymptomatic, a redox imbalance persists; this is probably caused by an absorption deficiency, even if slight. Dietary supplementation with antioxidant molecules may offer some benefit and deserves further investigation.
authors.affiliation: Department of Internal Medicine, University of Genoa, Italy. odetti@unige.it
authors.forename: P
authors.initials: P
authors.lastname: Odetti
authors.forename: S
authors.initials: S
authors.lastname: Valentini
authors.forename: I
authors.initials: I
authors.lastname: Aragno
authors.forename: S
authors.initials: S
authors.lastname: Garibaldi
authors.forename: M A
authors.initials: MA
authors.lastname: Pronzato
authors.forename: E
authors.initials: E
authors.lastname: Rolandi
authors.forename: T
authors.initials: T
authors.lastname: Barreca
mesh_terms: D000293:Adolescent; D000328:Adult; D001120:Arginine / Q000031:analogs & derivatives / Q000097:blood; D001798:Blood Proteins / Q000032:analysis* / Q000737:chemistry; D016022:Case-Control Studies; D002446:Celiac Disease / Q000378:metabolism*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008239:Lysine / Q000031:analogs & derivatives / Q000097:blood; D008297:Male; D018384:Oxidative Stress; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis* / Q000378:metabolism; D014801:Vitamin A / Q000097:blood; D014810:Vitamin E / Q000097:blood*
chemical_list: D001798:Blood Proteins; D008055:Lipids; D017392:Thiobarbituric Acid Reactive Substances; D014801:Vitamin A; D014810:Vitamin E; D001120:Arginine; C062187:pentosidine; D008239:Lysine