title: [Antiprotease and immunostimulating effect of peptide components isolated from cuticle of the chicken stomach].
abstract: Peptides with molecular weights of 0.8 to 16 kDa were isolated from the keratinous envelope of chicken muscular stomach cuticle. The peptide preparation had a immunostimulating activity whose qualitative and quantitative traits made it comparable with the activity of known drugs of similar composition. In addition, the peptide preparation reversibly inactivated trypsin and activated chymotrypsin. A low-molecular-weight protein (14.1 kDa) was isolated from the peptide preparation by affinity chromatography on trypsin-Sepharose 4B. This protein was found to be a reversible noncompetitive inhibitor of trypsin.
authors.affiliation: Pacific Fishery Research Center, Vladivostok, Russia.
authors.forename: T N
authors.initials: TN
authors.lastname: Pivnenko
authors.forename: L M
authors.initials: LM
authors.lastname: Epshteĭn
authors.forename: S V
authors.initials: SV
authors.lastname: Okladnikova
authors.forename: A K
authors.initials: AK
authors.lastname: Gazha
authors.forename: N N
authors.initials: NN
authors.lastname: Besednova
mesh_terms: D000276:Adjuvants, Immunologic / Q000302:isolation & purification*; D000818:Animals; D002645:Chickens; D002846:Chromatography, Affinity; D051379:Mice; D008970:Molecular Weight; D010455:Peptides / Q000302:isolation & purification*; D011480:Protease Inhibitors / Q000302:isolation & purification*; D013278:Stomach, Avian / Q000737:chemistry*
chemical_list: D000276:Adjuvants, Immunologic; D010455:Peptides; D011480:Protease Inhibitors