title: Peptidomimetic design.
abstract: Major discoveries have been made of new type-I and type-III peptidomimetic inhibitors of peptide-derived systems. Innovative reversible inhibitors of cysteine proteases and renin, and additional examples of peptidomimetic inhibitors of interleukin-1 beta-converting enzyme, neutral endopeptidase, herpes simplex virus protease, thrombin, HIV protease, Ras farnesyltransferase, the RGD motif, Factor Xa and various aspartic proteases have been discovered.
authors.affiliation: Department of Chemistry and School of Pharmacy, University of Wisconsin-Madison 53706, USA.
authors.forename: A S
authors.initials: AS
authors.lastname: Ripka
authors.forename: D H
authors.initials: DH
authors.lastname: Rich
mesh_terms: D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry; D005544:Forecasting; D018716:Molecular Mimicry; D010455:Peptides; D011487:Protein Conformation
chemical_list: D004791:Enzyme Inhibitors; D010455:Peptides; D016282:Aspartic Acid Endopeptidases