[Contact vasculitis caused by topical agents with non-steroidal anti-inflammatory agents or analgesics].
BACKGROUND
Topical non steroidal antiinflammatory drugs (NSAID) are recently used in France. Seven cases of contact vasculitis due to topical NSAID are reported.


METHODS
The clinical and histological features and follow-up data of seven patients with contact vasculitis due to topical NSAID were retrospectively reviewed.


RESULTS
The mean age of the seven patients (four women, three men) was 39 years. The topical NSAID used were: ketoprofene in four cases, mephenesine in one case and phenylbutazone in two cases. Cutaneous lesions occurred after a mean time of four days. Histological examination of a skin biopsy specimen showed a leucocytoclastic vasculitis in two cases, a lymphocytic vasculitis in two cases and a mixed vasculitis in three cases. Previous sensibilization to the drug was noted in five cases. Cutaneous patch tests with the drugs were positive in all cases.


CONCLUSIONS
The risk of systemic reaction after oral ingestion of the culprit drug may be considered in these patients.
Delbarre
M
M
Clinique Dermatologique, Hôpital Charles Nicolle, Rouen.
Joly
P
P
Balguerie
X
X
Thomine
E
E
Lauret
P
P
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D000700:Analgesics / Q000008:administration & dosage / Q000009:adverse effects*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D003877:Dermatitis, Contact / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012882:Skin Tests; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal