title: Expression of human transferrin receptor is controlled by a gene on chromosome 3: assignment using species specificity of a monoclonal antibody.
abstract: The monoclonal antibody OKT-9 has been shown to recognize the human transferrin receptor. We have exploited the species specificity of OKT-9 to map a gene controlling human transferrin receptor expression to chromosome 3, using human-mouse somatic cell hybrids. The gene for the human transferrin receptor and the gene controlling transferrin expression may be linked in humans.
authors.affiliation: Imperial Cancer Research Fund, London, U.K.
authors.forename: P N
authors.initials: PN
authors.lastname: Goodfellow
authors.forename: G
authors.initials: G
authors.lastname: Banting
authors.forename: R
authors.initials: R
authors.lastname: Sutherland
authors.forename: M
authors.initials: M
authors.lastname: Greaves
authors.forename: E
authors.initials: E
authors.lastname: Solomon
authors.forename: S
authors.initials: S
authors.lastname: Povey
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3; D003429:Cross Reactions; D005786:Gene Expression Regulation; D006801:Humans; D007457:Iodine Radioisotopes; D051379:Mice; D011233:Precipitin Tests; D011863:Radioimmunoassay; D011990:Receptors, Transferrin / Q000235:genetics* / Q000276:immunology*; D013045:Species Specificity
chemical_list: D000911:Antibodies, Monoclonal; D007457:Iodine Radioisotopes; D011990:Receptors, Transferrin