Chimeric SHIV that causes CD4+ T cell loss and AIDS in rhesus macaques.
By animal to animal passage in rhesus and pig-tailed macaques, we developed a rhesus model of HIV-1 disease in humans. Rhesus macaques infected with a cell-free stock of SHIVKU-2 developed CD4+ T cell loss, primary lentiviral encephalitis and pneumonia, and AIDS. Six of nine rhesus macaques died within eight months post-inoculation, while the remaining three are at five, five, and eight months post-inoculation, respectively. Animals infected by either mucosal or parenteral routes of infection had a similar course of infection.
Joag
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Marion Merrell Dow Laboratory of Viral Pathogenesis and Department of Microbiology, University of Kansas Medical Center, Kansas City 66160-7424, USA.
Li
Z
Z
Wang
C
C
Jia
F
F
Foresman
L
L
Adany
I
I
Pinson
D M
DM
Stephens
E B
EB
Narayan
O
O
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000503:physiopathology*; D000818:Animals; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002460:Cell Line; D005434:Flow Cytometry; D015752:Genes, env; D015757:Genes, rev; D015756:Genes, tat; D016338:Genes, vpu; D015497:HIV-1 / Q000235:genetics* / Q000276:immunology / Q000472:pathogenicity; D006801:Humans; D007108:Immune Tolerance; D008253:Macaca mulatta; D016865:Reassortant Viruses / Q000235:genetics* / Q000276:immunology / Q000472:pathogenicity; D015302:Simian Immunodeficiency Virus / Q000235:genetics* / Q000276:immunology / Q000472:pathogenicity; D013601:T-Lymphocytes / Q000821:virology; D014774:Virulence