title: Estimation of apoptosis in C6 glioma cells treated with antidepressants.
abstract: Gel electrophoresis of DNA was used for estimation of DNA changes caused in C6 glioma cells by treatment with psychotropic drugs (imipramine, amitryptiline and fluoxetine). Some discrete bands containing a population of short DNA fragments appeared after 1 and 5 days of cultivation. Apoptotic DNA breaks were verified at single cell level using the TUNEL test in cells treated with fluoxetine.
authors.affiliation: Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Brno.
authors.forename: A
authors.initials: A
authors.lastname: Spanová
authors.forename: H
authors.initials: H
authors.lastname: Kovárů
authors.forename: V
authors.initials: V
authors.lastname: Lisá
authors.forename: E
authors.initials: E
authors.lastname: Lukásová
authors.forename: B
authors.initials: B
authors.lastname: Rittich
mesh_terms: D000639:Amitriptyline / Q000494:pharmacology; D000928:Antidepressive Agents / Q000494:pharmacology*; D017209:Apoptosis; D053938:DNA Fragmentation / Q000187:drug effects; D005473:Fluoxetine / Q000494:pharmacology; D005910:Glioma / Q000473:pathology*; D006801:Humans; D007099:Imipramine / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D000928:Antidepressive Agents; D005473:Fluoxetine; D000639:Amitriptyline; D007099:Imipramine