MRI nerve root enhancement in Krabbe disease.
Krabbe disease is characterized by abnormal breakdown and turnover of myelin, leading to extensive demyelination in both the peripheral and central nervous systems. A 7-month-old infant with early-onset Krabbe disease had deceptively normal head images, but spinal MRI demonstrated abnormal gadolinium enhancement of the lumbosacral sacral nerve roots and cauda equina such as that seen in Guillain-Barré syndrome. Abnormal enhancement in spinal MRI has not been previously described in patients with leukodystrophies.
Vasconcellos
E
E
Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA.
Smith
M
M
D002420:Cauda Equina / Q000473:pathology; D006801:Humans; D007223:Infant; D007965:Leukodystrophy, Globoid Cell / Q000175:diagnosis*; D008161:Lumbosacral Region; D008279:Magnetic Resonance Imaging; D008297:Male; D013126:Spinal Nerve Roots / Q000473:pathology*