title: Accumulation of passively transferred primed T cells independently of their antigen specificity following central nervous system trauma.
abstract: The central nervous system (CNS) enjoys a unique relationship with the immune system. Under non-pathological conditions, T cells move through the CNS but do not accumulate there. CNS trauma has been shown to trigger a response to CNS self-antigens such as myelin basic protein (MBP). Here, we examined whether the injured CNS tissue undergoes changes that permit T cell accumulation. We found that injury to CNS white matter, such as the optic nerve, led to a transiently increased accumulation of T cells (between days 3 and 21). In Lewis rats with unilaterally injured optic nerves, systemic administration of passively transferred T cells recognizing either self-antigen (MBP) or non-self-antigen (ovalbumin) resulted in accumulation of the T cells in injured optic nerve, irrespective of their antigenic specificity. The effect of the T cells on the damaged nerve, the lack of selectivity in T cell accumulation and the mechanism underlying non-selective accumulation are discussed.
authors.affiliation: Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel. hirschberg@stanford.edu
authors.forename: D L
authors.initials: DL
authors.lastname: Hirschberg
authors.forename: G
authors.initials: G
authors.lastname: Moalem
authors.forename: J
authors.initials: J
authors.lastname: He
authors.forename: F
authors.initials: F
authors.lastname: Mor
authors.forename: I R
authors.initials: IR
authors.lastname: Cohen
authors.forename: M
authors.initials: M
authors.lastname: Schwartz
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000276:immunology; D001930:Brain Injuries / Q000276:immunology*; D002465:Cell Movement / Q000276:immunology*; D004396:Coloring Agents / Q000493:pharmacokinetics; D000939:Epitopes; D005070:Evans Blue / Q000493:pharmacokinetics; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D007700:Kinetics; D008213:Lymphocyte Activation / Q000276:immunology; D018655:Lymphocyte Count; D009409:Nerve Crush; D015213:Neuroimmunomodulation / Q000276:immunology; D009900:Optic Nerve / Q000737:chemistry / Q000276:immunology; D020221:Optic Nerve Injuries; D010047:Ovalbumin / Q000276:immunology; D051381:Rats; D011917:Rats, Inbred Lew; D011948:Receptors, Antigen, T-Cell / Q000032:analysis; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000637:transplantation
chemical_list: D004396:Coloring Agents; D000939:Epitopes; D005904:Glial Fibrillary Acidic Protein; D011948:Receptors, Antigen, T-Cell; D005070:Evans Blue; D010047:Ovalbumin