title: Improving source reconstructions by combining bioelectric and biomagnetic data.
abstract: OBJECTIVE
  A framework for combining bioelectric and biomagnetic data is presented. The data are transformed to signal-to-noise ratios and reconstruction algorithms utilizing a new regularization approach are introduced.
  
  
  METHODS
  Extensive simulations are carried out for 19 different EEG and MEG montages with radial and tangential test dipoles at different eccentricities and noise levels. The methods are verified by real SEP/SEF measurements. A common realistic volume conductor is used and the less well known in vivo conductivities are matched by calibration to the magnetic data. Single equivalent dipole fits as well as spatio-temporal source models are presented for single and combined modality evaluations and overlaid to anatomic MR images.
  
  
  RESULTS
  Normalized sensitivity and dipole resolution profiles of the different EEG/MEG acquisition systems are derived from the simulated data. The methods and simulations are verified by simultaneously measured somatosensory data.
  
  
  CONCLUSIONS
  Superior spatial resolution of the combined data studies is revealed, which is due to the complementary nature of both modalities and the increased number of sensors. A better understanding of the underlying neuronal processes can be achieved, since an improved differentiation between quasi-tangential and quasi-radial sources is possible.
authors.affiliation: Philips Research Laboratories Hamburg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Fuchs
authors.forename: M
authors.initials: M
authors.lastname: Wagner
authors.forename: H A
authors.initials: HA
authors.lastname: Wischmann
authors.forename: T
authors.initials: T
authors.lastname: Köhler
authors.forename: A
authors.initials: A
authors.lastname: Theissen
authors.forename: R
authors.initials: R
authors.lastname: Drenckhahn
authors.forename: H
authors.initials: H
authors.lastname: Buchner
mesh_terms: D001931:Brain Mapping; D003198:Computer Simulation; D004569:Electroencephalography / Q000379:methods* / Q000592:standards; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D006257:Head; D006801:Humans; D007091:Image Processing, Computer-Assisted; D015225:Magnetoencephalography / Q000379:methods* / Q000592:standards; D012984:Software