title: Serum pregnancy-specific beta1-glycoprotein before embryo transfer is related to endometrial thickness and to outcome prognosis in women undergoing in-vitro fertilization treatment.
abstract: We have previously observed the repeated presence of low but detectable amounts of the trophoblast marker pregnancy-specific beta1-glycoprotein (SP1) in the serum of some women undergoing in-vitro fertilization (IVF) treatment around the time of oocyte retrieval. The occurrence of these signals seemed to be restricted to a defined group of patients which also showed a lower pregnancy success rate in a preliminary study. To test our hypothesis we have analysed 173 consecutive cycles leading to an embryo transfer. Fifty-four cycles (31%) had a serum SP1 level of at least 0.1 ng/ml between days embryo transfer -5 and embryo transfer (group A). Five pregnancies were obtained in this group (pregnancy rate = 9.3%), while in group B, defined by the absence of detectable SP1 before embryo transfer (119 cycles), 36 ongoing pregnancies were achieved (30.3%). Ten of the 41 pregnancies were achieved in 33 first-time non-pregnant patients undergoing further attempts during the study period. Again the pregnancy rate was higher in the first-time group B women (9/23 versus 1/10 for group A). Patients tended to remain in their groups A or B, the latter being associated with a better immediate as well as subsequent chance for pregnancy. Group A cycles had a significantly lower endometrial thickness two days before oocyte retrieval than group B (P = 0.0011). We postulate that the presence of an unknown, maternal and progesterone- or follicle stimulating hormone-independent factor in some patients could stimulate tonic ectopic SP1 synthesis and at the same time negatively influence endometrial development.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Berne, Switzerland.
authors.forename: N A
authors.initials: NA
authors.lastname: Bersinger
authors.forename: A
authors.initials: A
authors.lastname: Brandenberger
authors.forename: E
authors.initials: E
authors.lastname: Berger
authors.forename: C K
authors.initials: CK
authors.lastname: Baumann
authors.forename: M H
authors.initials: MH
authors.lastname: Birkhäuser
mesh_terms: D000328:Adult; D004624:Embryo Transfer; D004717:Endometrium / Q000473:pathology*; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000473:pathology / Q000628:therapy*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000032:analysis / Q000378:metabolism*; D011374:Progesterone / Q000097:blood
chemical_list: D011268:Pregnancy-Specific beta 1-Glycoproteins; D011374:Progesterone; D004958:Estradiol