title: No evidence for an association between a variant of the mast cell chymase gene and atopic dermatitis based on case-control and haplotype-relative-risk analyses.
abstract: Atopic dermatitis (AD) is a chronic relapsing dermatitis which belongs to the group of atopy-related diseases as well as asthma and allergic rhinitis. As a probable genetic risk which may contribute to the organ specificity of AD, an association between AD and a genetic variant of the gene encoding mast cell chymase (MCC), which has chymotrypsin-like specificity and is abundant in skin mast cells, has been reported in a Japanese population. We tried to confirm the role of this polymorphism in the development of AD in a Japanese population. A case-control analysis using 100 AD patients and 101 controls did not show a significant difference in the frequency of the BB genotype between the patient and control groups (odds ratio 1. 12, p = 0.81). The haplotype relative-risk analysis using 69 patient-parents trios did not suggest an association (chi2 = 0.177, p = 0.92). Thus, we failed to confirm the association between the polymorphism in the MCC gene and AD in the Japanese population.
authors.affiliation: Department of Dermatology, University of Tsukuba, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kawashima
authors.forename: E
authors.initials: E
authors.lastname: Noguchi
authors.forename: T
authors.initials: T
authors.lastname: Arinami
authors.forename: K
authors.initials: K
authors.lastname: Kobayashi
authors.forename: F
authors.initials: F
authors.lastname: Otsuka
authors.forename: H
authors.initials: H
authors.lastname: Hamaguchi
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002648:Child; D053818:Chymases; D003876:Dermatitis, Atopic / Q000201:enzymology / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008407:Mast Cells / Q000201:enzymology*; D016017:Odds Ratio; D012697:Serine Endopeptidases / Q000235:genetics*
chemical_list: D012697:Serine Endopeptidases; D053818:Chymases