MTHFR association with arteriosclerotic vascular disease?
Complex diseases are far more common than diseases that follow simple Mendelian patterns of inheritance. Difficulties are experienced in the designing of experiments to dissect out the contribution of a single allele to a complex phenotype. We review the literature regarding a point mutation in methylenetetrahydrofolate reductase, a candidate gene for susceptibility to vascular diseases.
Fletcher
O
O
Medical and Community Genetics, Imperial College School of Medicine, Northwick Park and St. Mark's NHS Trust, Harrow, UK.
Kessling
A M
AM
D000483:Alleles; D001161:Arteriosclerosis / Q000097:blood / Q000235:genetics*; D016206:Databases, Bibliographic; D005492:Folic Acid / Q000097:blood; D020022:Genetic Predisposition to Disease; D006710:Homocysteine / Q000097:blood; D006720:Homozygote; D006801:Humans; D016239:MEDLINE; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000235:genetics*; D017354:Point Mutation
D006710:Homocysteine; D005492:Folic Acid; D000587:Oxidoreductases Acting on CH-NH Group Donors; D042965:Methylenetetrahydrofolate Reductase (NADPH2)