title: High performance liquid chromatographic method for the determination of lobenzarit disodium in a sustained release tablet formulation.
abstract: A rapid and simple high performance liquid chromatographic method is described and validated for the determination of lobenzarit disodium (CAS 64808-48-6) in a sustained release tablet formulation. The calibration graph was linear over the range 20-105 micrograms/ml. The sensitivity (discriminator capacity) was 2.079 micrograms/ml. The coefficient of variations for repeatability and reproducibility were less than 1.60% and 1.30%, respectively. The accuracy of the method did not depend on lobenzarit concentration in tablets. The mean recovery was found to be 100.62%. The method was selective, even when degradation products were present.
authors.affiliation: Center of Pharmaceutical Chemistry, Havana, Cuba.
authors.forename: A
authors.initials: A
authors.lastname: Paneque
authors.forename: A I
authors.initials: AI
authors.lastname: Torres
authors.forename: M A
authors.initials: MA
authors.lastname: Camacho
mesh_terms: D018501:Antirheumatic Agents / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D003692:Delayed-Action Preparations; D015203:Reproducibility of Results; D013056:Spectrophotometry, Ultraviolet; D062367:ortho-Aminobenzoates / Q000032:analysis*
chemical_list: D018501:Antirheumatic Agents; D003692:Delayed-Action Preparations; D062367:ortho-Aminobenzoates; C015735:lobenzarit