title: [Prolonged neuromuscular blockade with mivacurium in a newborn].
abstract: Mivacurium is a short acting non-depolarising neuromuscular blocking agent. Short duration of action is due to a rapid hydrolysis by plasma cholinesterase (CHe). The duration of neuromuscular blockade can be prolonged by an abnormal variant of CHe. We report a case of a newborn with neuromuscular blockade for a duration of 8 hours following mivacurium 0.2 mg.kg-1. CHe activity values were not contributive for the diagnosis. The diagnosis was obtained with molecular study showing the new-born homozygocity. The whole family was heterozygous. This case emphasises the lack of precision of CHe activity measurement during the first 6 months of life.
authors.affiliation: Unité d'anesthésie-réanimation pédiatrique, hôpital Clocheville, Tours, France.
authors.forename: O
authors.initials: O
authors.lastname: Doucet
authors.forename: L
authors.initials: L
authors.lastname: Martin
authors.forename: M
authors.initials: M
authors.lastname: Laffon
authors.forename: A P
authors.initials: AP
authors.lastname: Jonville-Bera
authors.forename: C
authors.initials: C
authors.lastname: Mercier
mesh_terms: D002802:Cholinesterases / Q000097:blood / Q000235:genetics; D006720:Homozygote; D006801:Humans; D007231:Infant, Newborn; D007546:Isoquinolines / Q000627:therapeutic use*; D008297:Male; D000077590:Mivacurium; D003473:Neuromuscular Nondepolarizing Agents / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D007546:Isoquinolines; D003473:Neuromuscular Nondepolarizing Agents; D000077590:Mivacurium; D002802:Cholinesterases