Protective effect of oral administration of a traditional medicine, Juzen-Taiho-To, and its components on lethal Candida albicans infection in immunosuppressed mice.
Protective effects of a kampo medicine, Juzen-taiho-to (TJ-48) and its herbal components against experimental candidiasis in cyclophosphamide-induced immunosuppressive mice were investigated. ICR mice were immunosuppressed by intraperitoneal treatment with cyclophosphamide (day-4) and were orally given TJ-48 or one of its 10 herbal components for 4 consecutive days (day-4--1). They were then challenged intravenously with a lethal dose of Candida albicans (day 0). An oral dose of 1 g/kg/day of TJ-48 prolonged their life span. A similar protective effect was obtained by treatment with its component drugs Ginseng radix, Glycyrrhizae radix, Atractylodis lancea rhizoma or Cnidii rhizoma. These herbal components were suggested to have a main role in the protective effect of Juzen-taiho-to against Candida infection.
Abe
S
S
Department of Microbiology and Immunology, Teikyo University School of Medicine, Itabashi, Tokyo.
Tansho
S
S
Ishibashi
H
H
Inagaki
N
N
Komatsu
Y
Y
Yamaguchi
H
H
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000284:Administration, Oral; D000818:Animals; D002177:Candidiasis / Q000517:prevention & control*; D003520:Cyclophosphamide / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D007165:Immunosuppression Therapy; D051379:Mice; D008813:Mice, Inbred ICR
D000276:Adjuvants, Immunologic; D004365:Drugs, Chinese Herbal; C063587:juzentaihoto; D003520:Cyclophosphamide