[The role of thyroid hormones in prevention of disorders of myocardial contractile function and antioxidant activity during heat stress].
The stress of heat under conditions of immobilisation induced an obvious depression of the cardiodynamic parameters. This correlated well with intensification of lipoperoxydation and a drop in the myocardial antioxydant activity. Small doses of thyroid hormones prevented the decline of the parameters, normalisied myocardial free-radical homeostasis in result of activation of superoxyddysmutase, catalase, and general antioxydant activity.
Bozhko
A P
AP
Medical Institute, Vitebsk, Belorussia.
Gorodetskaia
I V
IV
D000222:Adaptation, Physiological / Q000187:drug effects; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D006321:Heart / Q000187:drug effects; D006358:Hot Temperature / Q000009:adverse effects*; D007103:Immobilization; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D013312:Stress, Physiological / Q000201:enzymology / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology*; D013963:Thyroid Hormones / Q000494:pharmacology / Q000502:physiology*
D000975:Antioxidants; D013963:Thyroid Hormones