title: Synovial chondromatosis: clonal chromosome changes provide further evidence for a neoplastic disorder.
abstract: Synovial chondromatosis is a rare lesion, which is still believed by most authors to be reactive rather than neoplastic. We report on a case of synovial chondromatosis with clonal chromosomal changes [43,XX,der (1) t (1;13) (p21-22;q21),-6,-13,-14, add(21) (q21)]. The presence of clonal chromosomal changes in this and in three previously reported cases suggests that synovial chondromatosis is a true neoplastic lesion.
authors.affiliation: Department of Pathology, University of Leuven, Belgium.
authors.forename: R
authors.initials: R
authors.lastname: Sciot
authors.forename: P
authors.initials: P
authors.lastname: Dal Cin
authors.forename: J
authors.initials: J
authors.lastname: Bellemans
authors.forename: I
authors.initials: I
authors.lastname: Samson
authors.forename: H
authors.initials: H
authors.lastname: Van den Berghe
authors.forename: B
authors.initials: B
authors.lastname: Van Damme
mesh_terms: D000328:Adult; D015838:Chondromatosis, Synovial / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1; D002882:Chromosomes, Human, Pair 13; D002883:Chromosomes, Human, Pair 14; D002891:Chromosomes, Human, Pair 21; D002896:Chromosomes, Human, Pair 6; D005260:Female; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D009369:Neoplasms / Q000235:genetics*; D014178:Translocation, Genetic