Lipid oxidation products and vascular function.
The endothelium and blood platelets are intimately involved in both the maintenance of vascular tone and in haemostasis. They are also exposed to high concentrations of lipoproteins, either in the plasma or in the sub-endothelial region of the artery wall, and the biological activity of these cells has been shown to be modulated. Oxidative modification of these lipoproteins results in further variations in the properties of these particles in relation to the activities of the endothelium and platelets. These effects and how the work of Hermann Esterbauer on the details of lipoprotein oxidation permitted rapid progress in understanding these phenomena are discussed in this review.
Bruckdorfer
K R
KR
Royal Free Hospital School of Medicine, University of London, UK.
D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D004730:Endothelium, Vascular / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000378:metabolism*; D009119:Muscle Contraction / Q000502:physiology; D009130:Muscle, Smooth / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D010084:Oxidation-Reduction
D008074:Lipoproteins; D009569:Nitric Oxide