title: Comparison of dextranomer paste and saline dressings for management of decubital ulcers.
abstract: In this open-label, parallel-group study, 23 male spinal cord injury patients aged 23 to 73 years (median 54 years) with a total of 30 exudative decubital ulcers were randomly allocated to receive treatment with dextranomer paste (15 ulcers) or conventional saline dressings (15 ulcers). Treatment was applied at least once every 12 hours and continued for a maximum of 15 days, until the ulcer was clean and covered with new granulation tissue and was suitable for skin grafting. The same physician assessed ulcer status (extent of drainage, granulation, erythema, and edema and the presence or absence of necrosis and epithelialization) each time the study nurse changed the dressings. Treatment with dextranomer paste resulted in significantly greater improvement in ulcer drainage compared with saline; 73% versus 13% of the ulcers, respectively, showed > or =25% improvement in drainage from baseline to the end of the study. Both treatments were well tolerated, with no evidence of any local irritation. Dextranomer paste was more effective than saline dressings in the management of decubital ulcers in spinal cord injury patients.
authors.affiliation: Pharmacia and Upjohn AB, Stockholm, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Ljungberg
mesh_terms: D000328:Adult; D000368:Aged; D001458:Bandages; D003911:Dextrans / Q000627:therapeutic use*; D004322:Drainage; D006801:Humans; D008297:Male; D008875:Middle Aged; D003668:Pressure Ulcer / Q000628:therapy*; D012965:Sodium Chloride / Q000627:therapeutic use*; D013119:Spinal Cord Injuries / Q000150:complications
chemical_list: D003911:Dextrans; C013471:dextranomer; D012965:Sodium Chloride