Mechanisms of p53-mediated apoptosis.
p53-mediated apoptosis of cells with DNA damage or oncogene overexpression is a major mechanism for its function as a tumor suppressor. Both transcriptionally dependent and transcriptionally independent activities of p53 can play a role in mediating cell death. It appears that p53 can induce apoptosis by multiple pathways in a manner which is regulated in a cell type and signal-specific fashion. Understanding the biochemical mechanisms of p53-dependent apoptosis holds a promise of manipulating these pathways in cancer therapy.
Ding
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Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Fisher
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D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D020169:Caspases / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D015805:HLA-DR5 Antigen / Q000235:genetics / Q000378:metabolism; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000235:genetics / Q000378:metabolism; D009369:Neoplasms / Q000473:pathology / Q000628:therapy*; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2; D014158:Transcription, Genetic; D016159:Tumor Suppressor Protein p53 / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D051028:bcl-2-Associated X Protein; D019014:fas Receptor / Q000235:genetics / Q000378:metabolism
D004268:DNA-Binding Proteins; D015805:HLA-DR5 Antigen; D018972:Insulin-Like Growth Factor Binding Protein 3; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53; D051028:bcl-2-Associated X Protein; D019014:fas Receptor; D020169:Caspases