title: A family-based analysis of whether the functional promoter alleles of the serotonin transporter gene HTT affect the risk for alcohol dependence.
abstract: A population association between a regulatory variation in the promoter of the serotonin transporter gene (HTT) and severe alcohol dependence was recently reported. We analyzed this potential association in a large number of systematically ascertained families in the United States; these families had at least three first-degree relatives who were alcohol-dependent. Analyses focused on individuals defined as alcohol-dependent by criteria from ICD-10 and on subsets of these individuals reporting withdrawal-related symptoms. Application of the transmission disequilibrium test did not provide support for either linkage or association between this functional polymorphism and alcohol dependence; there was no significant bias in the transmission of either allele to the alcohol-dependent offspring. We also report that African Americans differ from Caucasians in allele frequencies for this polymorphism.
authors.affiliation: Indiana University School of Medicine, Indianapolis 46202-5122, USA.
authors.forename: H J
authors.initials: HJ
authors.lastname: Edenberg
authors.forename: J
authors.initials: J
authors.lastname: Reynolds
authors.forename: D L
authors.initials: DL
authors.lastname: Koller
authors.forename: H
authors.initials: H
authors.lastname: Begleiter
authors.forename: K K
authors.initials: KK
authors.lastname: Bucholz
authors.forename: P M
authors.initials: PM
authors.lastname: Conneally
authors.forename: R
authors.initials: R
authors.lastname: Crowe
authors.forename: A
authors.initials: A
authors.lastname: Goate
authors.forename: V
authors.initials: V
authors.lastname: Hesselbrock
authors.forename: T K
authors.initials: TK
authors.lastname: Li
authors.forename: J I
authors.initials: JI
authors.lastname: Nurnberger
authors.forename: B
authors.initials: B
authors.lastname: Porjesz
authors.forename: T
authors.initials: T
authors.lastname: Reich
authors.forename: J P
authors.initials: JP
authors.lastname: Rice
authors.forename: M
authors.initials: M
authors.lastname: Schuckit
authors.forename: J A
authors.initials: JA
authors.lastname: Tischfield
authors.forename: T
authors.initials: T
authors.lastname: Foroud
mesh_terms: D000328:Adult; D000368:Aged; D000430:Alcohol Withdrawal Delirium / Q000235:genetics; D000437:Alcoholism / Q000235:genetics*; D000483:Alleles; D002352:Carrier Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D026901:Membrane Transport Proteins; D008875:Middle Aged; D009419:Nerve Tissue Proteins; D011110:Polymorphism, Genetic / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012307:Risk Factors; D050486:Serotonin Plasma Membrane Transport Proteins
chemical_list: D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins