title: [Hemodynamic effects of hypertonic saline solutions].
abstract: Haemodynamic effects of hypertonic saline solutions (HSS) have been extensively studied in animals and humans. Hypertonic sodium chloride (7.5%, 2,500 mOsm.L-1) either alone or combined with colloids, remains the standard solution. The haemodynamic response of HSS observed during treatment of hypovolaemic shock is explained by 1) an increase in preload due to the expansion of the plasma volume and a musculocutaneous vasoconstriction and 2) a decrease in systemic vascular resistance and afterload. A myocardial stimulation has been shown in various experimental conditions and in humans. However, the clinical relevance of this inotropic effect is questionable. Haemorrhagic shock is the main indication for small volume resuscitation with HSS. Other potential situations for the use of HSS are volume replacement in perioperative period, septic shock or burn injury and cardiopulmonary resuscitation. Before recommending the clinical use of HSS, additional clinical studies are required to substantiate the benefits of HSS over colloids.
authors.affiliation: Département des urgences, hôpital Pellegrin, Bordeaux, France.
authors.forename: F
authors.initials: F
authors.lastname: Sztark
authors.forename: J P
authors.initials: JP
authors.lastname: Gékière
authors.forename: P
authors.initials: P
authors.lastname: Dabadie
mesh_terms: D002056:Burns / Q000628:therapy; D006438:Hemodilution / Q000379:methods; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008833:Microcirculation / Q000187:drug effects; D012462:Saline Solution, Hypertonic / Q000494:pharmacology* / Q000627:therapeutic use; D012771:Shock, Hemorrhagic / Q000188:drug therapy; D016277:Ventricular Function, Left / Q000187:drug effects*; D014882:Water-Electrolyte Balance
chemical_list: D012462:Saline Solution, Hypertonic