Propranolol analog with the natural monoterpene structure as a potent antiarrhythmic drug.
Antiarrhythmic effects and intracellular electrophysiological properties of a new antiarrhythmic compound (-)trans-4-[2-hydroxy-3(N-isopropylamino)-propoxyimino]-cis-car ane (9) were studied in several models of arrhythmia and in isolated guinea-pig myocardial preparations. Compound 9 prevented the aconitine-induced arrhythmia, reversed the ouabin-induced arrhythmia depressed the maximum rate depolarization (Vmax), and shortened the action potential duration (ADP) and the effective refractory period (ERP). The data indicate that compound 9 is an effective antiarrhythmic presumably with a class 1 B mechanism of action.
Librowski
T
T
Department of Pharmacodynamics, Collegium Medicum Jagiellonian University, Kraków, Poland.
Filipek
B
B
Czarnecki
R
R
Beresewicz
A
A
Karwatowska-Prokopczuk
E
E
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000737:chemistry* / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000503:physiopathology / Q000517:prevention & control; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D011433:Propranolol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013729:Terpenes / Q000737:chemistry* / Q000494:pharmacology*
D000889:Anti-Arrhythmia Agents; D013729:Terpenes; D011433:Propranolol