title: MTHFR association with arteriosclerotic vascular disease?
abstract: Complex diseases are far more common than diseases that follow simple Mendelian patterns of inheritance. Difficulties are experienced in the designing of experiments to dissect out the contribution of a single allele to a complex phenotype. We review the literature regarding a point mutation in methylenetetrahydrofolate reductase, a candidate gene for susceptibility to vascular diseases.
authors.affiliation: Medical and Community Genetics, Imperial College School of Medicine, Northwick Park and St. Mark's NHS Trust, Harrow, UK.
authors.forename: O
authors.initials: O
authors.lastname: Fletcher
authors.forename: A M
authors.initials: AM
authors.lastname: Kessling
mesh_terms: D000483:Alleles; D001161:Arteriosclerosis / Q000097:blood / Q000235:genetics*; D016206:Databases, Bibliographic; D005492:Folic Acid / Q000097:blood; D020022:Genetic Predisposition to Disease; D006710:Homocysteine / Q000097:blood; D006720:Homozygote; D006801:Humans; D016239:MEDLINE; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000235:genetics*; D017354:Point Mutation
chemical_list: D006710:Homocysteine; D005492:Folic Acid; D000587:Oxidoreductases Acting on CH-NH Group Donors; D042965:Methylenetetrahydrofolate Reductase (NADPH2)