title: [Aggravation of acne by isotretinoin. 6 cases, predictive factors].
abstract: OBJECTIVE
  Acne flare-ups are frequent in the early phase of isotretinoin treatment. Severity varies from one patient to another. Clinical factors favoring a potentially severe course were assessed on the basis of 6 cases.
  
  
  METHODS
  Six male patients, mean age 16.5 years, with inflammatory acne with a major retentional component were studied. Isotretinoin administered at a daily dose 0.5 mg/kg led to explosive development of massive nodulocystic lesions or pyogenic granulomas within two months. The lesions healed at withdrawal of isotretinoin and administration of antibiotics and antiinflammatory drugs. There was important scar sequellae.
  
  
  CONCLUSIONS
  Four concomitant factors were identified which contribute to the development of acne flare-ups: sex (male), young age, retentional form of acne and daily isotretinoin dose 0.5 mg/kg.
authors.affiliation: Service Dermatologie, Hôpital Saint-Louis, Paris.
authors.forename: D
authors.initials: D
authors.lastname: Lehucher Ceyrac
authors.forename: C
authors.initials: C
authors.lastname: Chaspoux
authors.forename: L
authors.initials: L
authors.lastname: Sulimovic
authors.forename: P
authors.initials: P
authors.lastname: Morel
authors.forename: H
authors.initials: H
authors.lastname: Lefrancq
mesh_terms: D000152:Acne Vulgaris / Q000139:chemically induced* / Q000188:drug therapy; D000293:Adolescent; D004305:Dose-Response Relationship, Drug; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology*; D017789:Granuloma, Pyogenic / Q000139:chemically induced / Q000175:diagnosis; D006801:Humans; D015474:Isotretinoin / Q000008:administration & dosage / Q000009:adverse effects*; D007641:Keratolytic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D012307:Risk Factors
chemical_list: D007641:Keratolytic Agents; D015474:Isotretinoin