Lysophosphatidylcholine upregulates CD40 ligand expression in newly activated human CD4+ T cells.
Lysophosphatidylcholine (lyso-PC) accumulates in tissues undergoing inflammation and atherosclerosis, where an infiltration of T cells is also seen. We found that lyso-PC increased IFN-gamma production and CD40L expression in CD4+ T cells stimulated with anti-CD3 Ab and recombinant CD80 molecules, whereas lyso-PC did not affect IL-2 and IL-4 production. These results suggest that lyso-PC, in combination with other stimuli, may regulate CD4+ T cell functions to propagate local inflammatory reactions and also imply a novel role played by a modified lipid in the selection of Th1/Th2 immune response as well as in the T cell mediated pathogenesis in atherosclerosis.
Sakata-Kaneko
S
S
Department of Clinical Bio-regulatory Science, Kyoto University Graduate School of Medicine, Japan.
Wakatsuki
Y
Y
Usui
T
T
Matsunaga
Y
Y
Itoh
T
T
Nishi
E
E
Kume
N
N
Kita
T
T
D000906:Antibodies / Q000494:pharmacology; D018122:B7-1 Antigen / Q000276:immunology; D017252:CD3 Complex / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D023201:CD40 Ligand; D002460:Cell Line; D018920:Coculture Techniques; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis; D008213:Lymphocyte Activation; D008244:Lysophosphatidylcholines / Q000494:pharmacology*; D008562:Membrane Glycoproteins / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism; D011994:Recombinant Proteins / Q000276:immunology
D000906:Antibodies; D018122:B7-1 Antigen; D017252:CD3 Complex; D008244:Lysophosphatidylcholines; D008562:Membrane Glycoproteins; D012333:RNA, Messenger; D011994:Recombinant Proteins; D023201:CD40 Ligand; D007371:Interferon-gamma