Isoniazid-induced crescentic glomerulonephritis in a child with a positive tuberculin skin test.
Acute nonoliguric renal failure developed in a 13-year-old girl, 1 month after the institution of isoniazid therapy because of a positive tuberculin test at school screening. A renal biopsy demonstrated severe crescentic glomerulonephritis with focal interstitial changes. Discontinuation of isoniazid and a short course of steroids and cyclophosphamide therapy were followed by complete recovery. Whereas isoniazid has been shown to induce a lupus-like syndrome and antihistone antinuclear antibodies, our patient displayed none of the clinical or immunological features that are characteristic of drug-induced lupus. Furthermore, none of the identifiable causes for crescentic glomerulonephritis was evident in this girl. To the best of our knowledge this is the first report suggesting a possible association of crescentic glomerulonephritis to isoniazid treatment.
Brik
R
R
Division of Pediatrics, Rambam Medical Center and Technion, Faculty of Medicine, Haifa, Israel.
Magen
D
D
Ben-Yzhak
O
O
Grin
J
J
D000293:Adolescent; D000995:Antitubercular Agents / Q000009:adverse effects*; D018450:Disease Progression; D005260:Female; D005921:Glomerulonephritis / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects*; D007668:Kidney / Q000473:pathology; D014374:Tuberculin Test
D000995:Antitubercular Agents; D007538:Isoniazid