title: Follow-up of improvement in regional cerebral blood flow and mental status in Alzheimer's disease: a case report.
abstract: Cerebral SPECT imaging has the potential to make important contributions in the follow-up care of patients with Alzheimer's disease. An unusual case of a patient who showed a follow-up cerebral blood flow pattern different from that routinely seen in Alzheimer's disease patients is reported here. Qualitative and voxel-based objective evaluation of follow-up scans revealed improvement in parietotemporal deficits that had been observed on a baseline study. This change was observed without significant further deterioration in ratings by dementia batteries. This case shows that a baseline regional cerebral blood flow study might be necessary for reference and comparison in the proper follow-up care of Alzheimer's disease patients.
authors.affiliation: Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
authors.forename: M B
authors.initials: MB
authors.lastname: Imran
authors.forename: S
authors.initials: S
authors.lastname: Awata
authors.forename: R
authors.initials: R
authors.lastname: Kawashima
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: H
authors.initials: H
authors.lastname: Ito
authors.forename: S
authors.initials: S
authors.lastname: Ono
authors.forename: S
authors.initials: S
authors.lastname: Yoshioka
authors.forename: S
authors.initials: S
authors.lastname: Ota
authors.forename: M
authors.initials: M
authors.lastname: Sato
authors.forename: H
authors.initials: H
authors.lastname: Fukuda
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000503:physiopathology; D001921:Brain / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D018697:Nootropic Agents / Q000627:therapeutic use; D011760:Pyrrolidinones / Q000627:therapeutic use; D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D018697:Nootropic Agents; D011760:Pyrrolidinones; D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime; C036466:aniracetam