Low-molecular-weight heparins: pharmacologic profile and product differentiation.
The interchangeability of low-molecular-weight heparins (LMWHs) has been the subject of discussion since these products were first introduced for the prophylaxis of deep vein thrombosis. Experimental evidence now exists to show that LMWHs differ from each other in a number of characteristics. Products have been differentiated on the basis of molecular weight and biologic properties, but only limited information derived from the clinical setting is available. Potency has been described on the basis of anti-Factor Xa activity, but at equivalent anti-Xa activities, the anti-Factor IIa activity of different products shows marked variations. At the relatively small doses used for the management of postsurgical deep vein thrombosis, the effect of these interproduct differences may be relatively minor, but as LMWHs are developed for therapeutic use at much higher doses, such differences may become clinically important. Variations in safety and efficacy reported in clinical trials of LMWHs may reflect the known differences in their molecular composition and pharmacologic properties.
Fareed
J
J
Department of Pathology, Loyola University Medical Center, Maywood, Illinois 60153, USA.
Jeske
W
W
Hoppensteadt
D
D
Clarizio
R
R
Walenga
J M
JM
D000818:Animals; D000925:Anticoagulants / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D016903:Drug Monitoring; D015951:Factor Xa / Q000378:metabolism; D065427:Factor Xa Inhibitors; D006495:Heparin, Low-Molecular-Weight / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D011516:Prothrombin / Q000037:antagonists & inhibitors / Q000378:metabolism; D012449:Safety; D013927:Thrombosis / Q000097:blood / Q000517:prevention & control; D016896:Treatment Outcome
D000925:Anticoagulants; D065427:Factor Xa Inhibitors; D006495:Heparin, Low-Molecular-Weight; D011516:Prothrombin; C025337:Factor IIa; D015951:Factor Xa