Crosslinked dextran--a new capsule material for colon targeting of drugs.
In the work presented here we have studied the application of glutaraldehyde crosslinked dextran as a capsule material for colon-specific drug delivery. A reaction mixture containing dextran, MgCl2, glutaraldehyde and polyethyleneglycol 400 in water was applied onto molding pins of nylon producing capsule caps and bodies. The capsule materials were characterized by measuring of the mechanical strength in compression and equilibrium degree of swelling. Based on these results an optimal composition for the capsule material was selected. The dextran capsules were loaded with hydrocortisone and subsequently, drug release was studied. The release was found to be about 10% during the initial 3 h in a buffer solution. Over a period of 24 h the release was about 35%. However, when the dextran capsules were challenged with a dextranase solution, simulating the arrival of the drug delivery system to the colon, the capsules quickly broke and the drug was released as a dose dump. The study shows that the dextran capsules are promising candidates for providing a colon-specific drug delivery.
Brøndsted
H
H
Royal Danish School of Pharmacy, Department of Pharmaceutics, Copenhagen.
Andersen
C
C
Hovgaard
L
L
D002214:Capsules; D003106:Colon; D003432:Cross-Linking Reagents / Q000737:chemistry; D003911:Dextrans / Q000737:chemistry*; D004337:Drug Carriers; D005976:Glutaral / Q000737:chemistry; D019563:Mechanics; D008854:Microscopy, Electron
D002214:Capsules; D003432:Cross-Linking Reagents; D003911:Dextrans; D004337:Drug Carriers; D005976:Glutaral