title: Microglia, but not astrocytes, react to sciatic nerve injury in aging rats.
abstract: Peripheral nerve axotomy activates microglia and astrocytes within regions of brainstem or spinal cord from which the nerve arises. The present study demonstrates that unilateral sciatic axotomy in rats 2 to 18 months of age results in differing responses with age between these two glial populations. By 4 days postaxotomy, both astrocytes and microglia become activated in 2-month-old rats, whereas only the microglial population shows evidence of activation in rats 8 to 18 months of age.
authors.affiliation: Department of Anatomy-510, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA. sgilmore@exchange.uams.edu
authors.forename: S A
authors.initials: SA
authors.lastname: Gilmore
authors.forename: C J
authors.initials: CJ
authors.lastname: Kane
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001253:Astrocytes / Q000502:physiology*; D019771:Axotomy; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D017628:Microglia / Q000502:physiology*; D051381:Rats; D012016:Reference Values; D012584:Sciatic Nerve / Q000293:injuries*; D013116:Spinal Cord / Q000473:pathology / Q000503:physiopathology*; D014950:Wounds, Penetrating / Q000473:pathology / Q000503:physiopathology*
chemical_list: D005904:Glial Fibrillary Acidic Protein