title: A functionally distinct TATA box required for late progression through the Epstein-Barr virus life cycle.
abstract: During EBV infection, lytic DNA replication activates late gene expression in trans via an uncharacterized pathway. In this study, we mapped the target of this regulatory cascade to a variant TATA box (TATTAAA) and the 3' flanking region within the core promoter of the BcLF1 gene. The inherent late activity of this core promoter is, surprisingly, disrupted by a heterologous enhancer, suggesting that late gene expression is regulated through core promoter sequences located in a transcriptionally inert environment.
authors.affiliation: Department of Molecular Biophysics and Biochemistry, New Haven, Connecticut 06520, USA.
authors.forename: T R
authors.initials: TR
authors.lastname: Serio
authors.forename: N
authors.initials: N
authors.lastname: Cahill
authors.forename: M E
authors.initials: ME
authors.lastname: Prout
authors.forename: G
authors.initials: G
authors.lastname: Miller
mesh_terms: D001402:B-Lymphocytes / Q000821:virology; D001483:Base Sequence; D017931:DNA Primers; D015967:Gene Expression Regulation, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000502:physiology*; D006801:Humans; D016296:Mutagenesis; D011401:Promoter Regions, Genetic; D017384:Sequence Deletion; D016385:TATA Box
chemical_list: D017931:DNA Primers