[Co-trimoxazole administration: a rare cause of hypoglycemia in elderly persons].
We report a case of severe hypoglycaemia following co-trimoxazole therapy. An 88-year-old woman was admitted with urinary tract infection and treated with co-trimoxazole (960 mg bid). Seven days after initiation of the treatment she became comatose. Blood sugar was 1.3 mmol/l and C-peptide at the upper limit of normal range. Glucose infusion restored normal consciousness and no hypoglycaemia recurred after interruption of co-trimoxazole therapy. Advanced aged was the only risk factor identified. Other risk factors described in previous case reports are renal failure, poor nutritional state and high doses of co-trimoxazole.
Rutschmann
O T
OT
Département de médecine interne, Hôpitaux universitaires de Genève. Olivier.Rutschmann/hcuge.ch
Wicki
J
J
Micheli
P
P
Kondo Oestreicher
M
M
Guillermin Spahr
M L
ML
Droz
M
M
D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage / Q000009:adverse effects*; D014552:Urinary Tract Infections / Q000188:drug therapy*
D001786:Blood Glucose; D002096:C-Peptide; D015662:Trimethoprim, Sulfamethoxazole Drug Combination