title: Role of curdlan sulfate in the production of beta-chemokines and interleukin-16.
abstract: The blocking effect of curdlan sulfate (CRDS) on human immunodeficiency virus (HIV) infection has been thought to be related to inhibition of the binding of HIV-1 envelope glycoprotein (gp120) and CD4 molecules. However, recent reports have indicated that blocking the binding of gp120 to CD4 by CRDS only makes a small contribution to the inhibition of HIV-1 infection. We report here that the effect of CRDS on the production of beta-chemokines and cytokines might be important in the inhibition of HIV-1 infection, in addition to interference with the binding of gp120 to CD4+ cells.
authors.affiliation: Department of General Medicine, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Naito
authors.forename: N
authors.initials: N
authors.lastname: Takeda-Hirokawa
authors.forename: H
authors.initials: H
authors.lastname: Kaneko
authors.forename: I
authors.initials: I
authors.lastname: Sekigawa
authors.forename: T
authors.initials: T
authors.lastname: Matsumoto
authors.forename: H
authors.initials: H
authors.lastname: Hashimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Kaneko
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D054407:Chemokine CCL4; D019742:Chemokines, CC / Q000276:immunology* / Q000378:metabolism; D005936:Glucans / Q000494:pharmacology*; D015699:HIV Envelope Protein gp120 / Q000187:drug effects* / Q000378:metabolism; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D019410:Interleukin-16 / Q000276:immunology* / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000821:virology; D019402:Macrophage Inflammatory Proteins / Q000276:immunology / Q000378:metabolism; D047071:beta-Glucans
chemical_list: D000998:Antiviral Agents; D054407:Chemokine CCL4; D019742:Chemokines, CC; D005936:Glucans; D015699:HIV Envelope Protein gp120; D019410:Interleukin-16; D019402:Macrophage Inflammatory Proteins; D047071:beta-Glucans; C063130:curdlan sulfate