The basic chemistry of nitrogen monoxide and peroxynitrite.
After a discussion of the physical chemistry of nitrogen monoxide, such as solubility (1.55 mM at 37 degrees C and an ionic strength of 0.15 M) and diffusion constant (4.8 x 10(-5) cm2s(-1)), several reactions that can acts as sinks are discussed, namely the reaction with dioxygen, with thiols and with superoxide. Of these, the latter reaction leads to a powerful oxidant, peroxynitrite. The thermodynamic and kinetic properties of this molecule are also reviewed.
Koppenol
W H
WH
Laboratorium für Anorganische Chemie, Eidgenössische Technische Hochschule, Zürich, Switzerland. koppenol@inorg.chem.ethz.ch
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004058:Diffusion; D009566:Nitrates / Q000737:chemistry*; D009569:Nitric Oxide / Q000737:chemistry*; D010084:Oxidation-Reduction; D012995:Solubility; D013482:Superoxide Dismutase; D013816:Thermodynamics
D009566:Nitrates; C039642:peroxynitric acid; D009569:Nitric Oxide; D013482:Superoxide Dismutase