title: The effects of histamine H3-receptor antagonists on amygdaloid kindled seizures in rats.
abstract: The effects of histamine H3-receptor antagonists, thioperamide, and clobenpropit on amygdaloid kindled seizures were investigated in rats. Both intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) injections of H3-antagonists resulted in a dose-related inhibition of amygdaloid kindled seizures. An inhibition induced by thioperamide was antagonized by an H3-agonist [(R)-alpha-methylhistamine] and H1-antagonists (diphenhydramine and chlorpheniramine). On the other hand, an H2-antagonist (cimetidine and ranitidine) caused no antagonistic effect. Metoprine, an inhibitor of N-methyltransferase was also effective in inhibiting amygdaloid kindled seizure, and this effect was augmented by thioperamide treatment.
authors.affiliation: Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kakinoki
authors.forename: K
authors.initials: K
authors.lastname: Ishizawa
authors.forename: M
authors.initials: M
authors.lastname: Fukunaga
authors.forename: Y
authors.initials: Y
authors.lastname: Fujii
authors.forename: C
authors.initials: C
authors.lastname: Kamei
mesh_terms: D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006633:Histamine Antagonists / Q000494:pharmacology*; D006637:Histamine N-Methyltransferase / Q000037:antagonists & inhibitors; D007093:Imidazoles / Q000008:administration & dosage / Q000494:pharmacology; D007276:Injections, Intraventricular; D007696:Kindling, Neurologic / Q000502:physiology; D008297:Male; D010880:Piperidines / Q000008:administration & dosage / Q000494:pharmacology; D011739:Pyrimethamine / Q000031:analogs & derivatives / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D018100:Receptors, Histamine H3 / Q000378:metabolism*; D012640:Seizures / Q000503:physiopathology*; D013890:Thiourea / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D006633:Histamine Antagonists; D007093:Imidazoles; D010880:Piperidines; D018100:Receptors, Histamine H3; C006308:metoprine; D006637:Histamine N-Methyltransferase; D013890:Thiourea; C052075:thioperamide; C086108:clobenpropit; D011739:Pyrimethamine