title: Residual lateral wall defects following sinus grafting with recombinant human osteogenic protein-1 or Bio-Oss in the chimpanzee.
abstract: Sinus grafting procedures are a viable means of ensuring adequate bone for the placement of dental implants in the posterior maxilla. In the quest to improve predictability and accelerate the time line toward receiving a final prosthesis, researchers have turned to recombinant human proteins like osteogenic protein-1 for the potential to therapeutically enhance bone formation. Bilateral sinus augmentations were performed in 15 adults chimpanzees to evaluate treatment with different doses of the osteogenic protein-1 device or natural bone mineral (Bio-Oss). Methods of evaluation included soft tissue healing, radiography (computed tomographic scan), histology, residual lateral wall defect surface area at 7.5 months, and the extent of soft tissue encleftation at 7.5 months. Findings revealed radiographic and histologic evidence of bone formation with all treatment groups and a statistically significant reduction in the depth of soft tissue encleftation and the residual lateral wall defect surface area for both the Bio-Oss and the 2.5-mg osteogenic protein-1 per gram collagen matrix treatments when compared to collagen matrix alone. These results suggest that Bio-Oss and the 2.5-mg osteogenic protein-1 per gram collagen matrix effectively stimulate bone formation in the maxillary sinus.
authors.affiliation: Department of Periodontology, Northwest Wound Healing Center, Oregon Health Sciences University, Portland 97201, USA.
authors.forename: B S
authors.initials: BS
authors.lastname: McAllister
authors.forename: M D
authors.initials: MD
authors.lastname: Margolin
authors.forename: A G
authors.initials: AG
authors.lastname: Cogan
authors.forename: M
authors.initials: M
authors.lastname: Taylor
authors.forename: J
authors.initials: J
authors.lastname: Wollins
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins / Q000494:pharmacology; D001861:Bone Regeneration / Q000187:drug effects*; D016025:Bone Transplantation / Q000379:methods*; D002417:Cattle; D003094:Collagen; D005069:Evaluation Studies as Topic; D006801:Humans; D008443:Maxillary Sinus / Q000601:surgery*; D008903:Minerals / Q000494:pharmacology; D013516:Oral Surgical Procedures, Preprosthetic; D002679:Pan troglodytes; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; D014945:Wound Healing
chemical_list: C525819:BMP7 protein, human; C077540:Bio-Oss; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D008903:Minerals; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; D003094:Collagen