Platelet function in autoimmune (idiopathic) thrombocytopenic purpura.
Platelets play an essential role in the formation of haemostatic plugs. The quantitative defect of platelets in autoimmune (idiopathic) thrombocytopenic purpura (ITP) can result in bleeding complications, but most ITP patients have platelets with normal or enhanced function. Platelets in ITP are large, young, so-called "stress" platelets with increased platelet-associated autoimmune antibody (immunoglobulin G). Young stress platelets are more functional platelets, and their presence may account for bleeding times in ITP patients that are shorter than would be predicted on the basis of the patients' (low) platelet counts. Some ITP patients have significant mucocutaneous bleeding with platelet counts >50 x 10(9) l(-1); this may be due to qualitative platelet dysfunction (e.g. brought about by inhibitory antiplatelet autoantibodies).
Rand
M L
ML
The Hospital for Sick Children, and Department of Biochemistry, University of Toronto, Ontario, Canada.
Dean
J A
JA
D001323:Autoantibodies; D001792:Blood Platelets / Q000502:physiology*; D006487:Hemostasis; D006801:Humans; D007074:Immunoglobulin G; D015539:Platelet Activation; D010974:Platelet Aggregation; D010979:Platelet Function Tests; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000276:immunology*
D001323:Autoantibodies; D007074:Immunoglobulin G