Metabolism of ethanol and some associated adverse effects on the liver and the stomach.
Current knowledge of alcohol oxidation and its effects on hepatic metabolism and its toxicity are summarized. This includes an evaluation of the relationship of the level of consumption to its interaction with nutrients (especially retinoids, carotenoids, and folate) and the development of various stages of liver disease. Ethanol metabolism in the stomach and its link to pathology and Helicobacter pylori is reviewed. Promising therapeutic approaches evolving from newly gained insight in the pathogenesis of medical complications of alcoholism are outlined. At present, the established approach for the prevention and treatment of alcoholism are outlined. At present, the established approach for the prevention and treatment of alcoholic liver injury is to control alcohol abuse, with the judicial application of selective antioxidant therapy, instituted at early stages, prior to the social or medical disintegration of the patient, and associated with antiinflammatory agents at the acute phase of alcoholic hepatitis. In addition, effective antifibrotic therapy may soon become available.
Lieber
C S
CS
Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA.
Leo
M A
MA
D000426:Alcohol Dehydrogenase / Q000502:physiology; D000428:Alcohol Drinking / Q000009:adverse effects* / Q000097:blood; D000431:Ethanol / Q000009:adverse effects / Q000493:pharmacokinetics*; D016481:Helicobacter Infections / Q000201:enzymology / Q000209:etiology; D016480:Helicobacter pylori; D006801:Humans; D008099:Liver / Q000201:enzymology; D008108:Liver Diseases, Alcoholic / Q000201:enzymology / Q000209:etiology*; D010084:Oxidation-Reduction; D012307:Risk Factors; D013270:Stomach / Q000201:enzymology; D013272:Stomach Diseases / Q000201:enzymology / Q000209:etiology*
D000431:Ethanol; D000426:Alcohol Dehydrogenase