title: [Hyperexpression of the multiple drug resistance gene (MDR-1) in chronic myeloleukemia patients].
abstract: OBJECTIVE
  To elucidate prognostic value of MDR-1 gene expression in patients with chronic myeloid leukemia (CML).
  
  
  METHODS
  The MDR-1 gene expression was studied by in situ hybridization in hemopoietic cells of 63 Ph-positive CML patients in different phases of the disease. The survival of the patients and duration of the chronic phase (CP) were evaluated using the Caplan-Meyer method.
  
  
  RESULTS
  MDR-1-positive patients had a shorter survival (p < 0.01) and CP (p < 0.05) than negative ones. MDR-1 gene overexpression has no impact either on the survival or duration of AP and BP (p < 0.05). Moreover, the MDR-1 gene overexpression is not dependent either on the previous treatment or other prognostic markers.
  
  
  CONCLUSIONS
  Overexpression of MDR-1 gene is an independent prognostic factor and an additional parameter to Sokal's scores.
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Stiuf
authors.forename: T V
authors.initials: TV
authors.lastname: Bykova
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Zaritskiĭ
authors.forename: O I
authors.initials: OI
authors.lastname: Frolova
authors.forename: O V
authors.initials: OV
authors.lastname: Marinets
authors.forename: B V
authors.initials: BV
authors.lastname: Afanas'ev
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015342:DNA Probes; D005260:Female; D015973:Gene Expression Regulation, Leukemic / Q000235:genetics*; D019450:Genes, MDR / Q000235:genetics*; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D015342:DNA Probes