title: Warfarin-induced skin necrosis.
abstract: Skin necrosis is an uncommon complication of warfarin (Coumadin; Dupont Pharma, Wilmington, DE) therapy. The presentation may mimic other disorders. This article reports a case of a 72-year-old woman who presented to the emergency department complaining of swelling and ecchymosis to her left breast and right foot. The patient had been hospitalized for coronary artery bypass grafting, and had been discharged from the hospital earlier that day. This article reviews the pathophysiology and clinical features of warfarin-induced skin necrosis.
authors.affiliation: Department of Emergency Medicine, Summa Health System, Akron, OH 44304, USA.
authors.forename: T J
authors.initials: TJ
authors.lastname: Gelwix
authors.forename: M S
authors.initials: MS
authors.lastname: Beeson
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000009:adverse effects*; D001941:Breast Diseases / Q000139:chemically induced* / Q000473:pathology*; D003937:Diagnosis, Differential; D004632:Emergency Medical Services; D005260:Female; D005533:Foot Dermatoses / Q000139:chemically induced* / Q000473:pathology*; D006801:Humans; D009336:Necrosis; D012867:Skin / Q000187:drug effects* / Q000473:pathology*; D014859:Warfarin / Q000009:adverse effects*
chemical_list: D000925:Anticoagulants; D014859:Warfarin