title: Antimalarial activities of polyhydroxyphenyl and hydroxamic acid derivatives.
abstract: Several known mammalian ribonucleotide reductase inhibitors featuring a polyhydroxyphenyl and/or hydroxamate moiety as the active group were screened for potency in inhibiting growth of the malaria parasite Plasmodium falciparum. Compounds containing a 2,3- or 3,4-dihydroxyphenyl group as well as benzohydroxamate appear to be the most effective inhibitors of the malaria parasite.
authors.affiliation: Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, Florida 32611, USA.
authors.forename: K P
authors.initials: KP
authors.lastname: Holland
authors.forename: H L
authors.initials: HL
authors.lastname: Elford
authors.forename: V
authors.initials: V
authors.lastname: Bracchi
authors.forename: C G
authors.initials: CG
authors.lastname: Annis
authors.forename: S M
authors.initials: SM
authors.lastname: Schuster
authors.forename: D
authors.initials: D
authors.lastname: Chakrabarti
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D006877:Hydroxamic Acids / Q000494:pharmacology*; D006918:Hydroxyurea / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects; D012264:Ribonucleotide Reductases / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
chemical_list: D000962:Antimalarials; D006877:Hydroxamic Acids; D012264:Ribonucleotide Reductases; D006918:Hydroxyurea