title: Technology and biopharmaceutical availability of solid ocular inserts containing sulfadicramide and some promoters.
abstract: Technology for obtaining solid ocular inserts made of poly(vinyl alcohol), containing sulfadicramide and some sorption promoters, was worked out. The rate of drug release was studied by assuming the pseudo-first order kinetics to hold true. An isolated animal cornea was used to measure the coefficients of permeability and the efficiency of sulfadicramide penetration through these corneas.
authors.affiliation: Department of Physical Chemistry, K. Marcinkowski University of Medical Sciences, Poznań, Poland.
authors.forename: E
authors.initials: E
authors.lastname: Grześkowiak
mesh_terms: D000577:Amides / Q000493:pharmacokinetics*; D000818:Animals; D001682:Biological Availability; D004304:Dosage Forms; D005123:Eye / Q000378:metabolism*; D066298:In Vitro Techniques; D013552:Swine
chemical_list: D000577:Amides; D004304:Dosage Forms