title: Hirsutes. II: Treatment.
abstract: The treatment of hirsutes includes cosmetic measures, such as bleaching, plucking, electrical epilation and, more recently, laser epilation. Pharmacological therapy consists of anti-androgens and includes the androgen receptor blockers spironolactone and cyproterone acetate. Other drugs reducing androgen expression include oral contraceptives and corticosteroids. A new follicular 5 alpha reductase inhibitor, finasteride, is currently under evaluation, as is the anti-androgen flutamide. Gonadotrophin-releasing hormone agonists reduce androgen expression and show early promise in the treatment of hirsutes.
authors.affiliation: University of Melbourne, Department of Medicine (Dermatology), St Vincent's Hospital, Melbourne, Fitzroy, Victoria, Australia.
authors.forename: R
authors.initials: R
authors.lastname: Young
authors.forename: R
authors.initials: R
authors.lastname: Sinclair
mesh_terms: D058891:5-alpha Reductase Inhibitors; D000726:Androgen Antagonists / Q000627:therapeutic use; D059002:Androgen Receptor Antagonists; D003276:Contraceptives, Oral / Q000627:therapeutic use; D003358:Cosmetics / Q000627:therapeutic use; D017373:Cyproterone Acetate / Q000627:therapeutic use; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D005260:Female; D018120:Finasteride / Q000627:therapeutic use; D005485:Flutamide / Q000627:therapeutic use; D005938:Glucocorticoids / Q000627:therapeutic use; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists; D006204:Hair Removal / Q000379:methods; D006628:Hirsutism / Q000188:drug therapy / Q000628:therapy*; D006801:Humans; D053685:Laser Therapy; D000451:Mineralocorticoid Receptor Antagonists / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use; D013148:Spironolactone / Q000627:therapeutic use
chemical_list: D058891:5-alpha Reductase Inhibitors; D000726:Androgen Antagonists; D059002:Androgen Receptor Antagonists; D003276:Contraceptives, Oral; D003358:Cosmetics; D004791:Enzyme Inhibitors; D005938:Glucocorticoids; D000451:Mineralocorticoid Receptor Antagonists; D013148:Spironolactone; D007987:Gonadotropin-Releasing Hormone; D017373:Cyproterone Acetate; D018120:Finasteride; D005485:Flutamide; D011239:Prednisolone