title: Comparative bioavailability study of codeine and ibuprofen after administration of the two products alone or in association to 24 healthy volunteers.
abstract: The study objective was to compare the bioavailability of codeine and ibuprofen after oral administration of the two drugs alone or in association. The study was performed in three different periods, each separated by a wash-out of 6 days. Plasma concentrations were measured in 24 healthy volunteers after administration of a single oral dose of codeine phosphate (25 mg) and/or ibuprofen (200 mg). Codeine and ibuprofen assays were performed using two different HPLC methods. The relative bioavailabilities of codeine and ibuprofen (alone or in association) were 106 +/- 24% (mean +/- sd) and 101 +/- 19%, respectively. The results obtained demonstrated that bioavailabilities of codeine and ibuprofen were not modified when the two drugs were administrated alone or in association.
authors.affiliation: Adme Bioanalyses, Parc Haute Technologie, Mougins, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Laneury
authors.forename: P
authors.initials: P
authors.lastname: Duchene
authors.forename: P
authors.initials: P
authors.lastname: Hirt
authors.forename: A
authors.initials: A
authors.lastname: Delarue
authors.forename: S
authors.initials: S
authors.lastname: Gleizes
authors.forename: G
authors.initials: G
authors.lastname: Houin
authors.forename: P
authors.initials: P
authors.lastname: Molinier
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000378:metabolism / Q000493:pharmacokinetics*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000097:blood / Q000493:pharmacokinetics*; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D003061:Codeine / Q000378:metabolism / Q000493:pharmacokinetics*; D018592:Cross-Over Studies; D004347:Drug Interactions; D006801:Humans; D007052:Ibuprofen / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male
chemical_list: D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D003061:Codeine; D007052:Ibuprofen