title: Analysis of methods for reducing false positives in the automated detection of clustered microcalcifications in mammograms.
abstract: Clustered microcalcifications are often the first sign of breast cancer in a mammogram. Nevertheless, all clustered microcalcifications are not found by an individual radiologist reading a mammogram. The use of a second reader may find those clusters of microcalcifications not found by the first reader, thereby improving the sensitivity of detecting clustered microcalcifications. Our laboratory has developed a computerized scheme for the detection of clustered microcalcifications, which can act like a second reader, that is undergoing clinical evaluation. This paper concerns the feature analysis stage of the computer scheme, which is designed to remove some of the false-computer detections. We have examined three methods of feature analysis, namely, rule based (the method currently used), an artificial neural network (ANN), and a combined method. In an independent database of 50 images, at a sensitivity of 83%, the average number of false positive (FP) detections per image was: 1.9 for rule-based, 1.6 for ANN, and 0.8 for the combined method. We demonstrate that the combined method performs best because each of the two stages eliminates different types of false positives.
authors.affiliation: Kurt Rossmann Laboratories for Radiologic Image Research, Department of Radiology, University of Chicago, Illinois 60637, USA.
authors.forename: R H
authors.initials: RH
authors.lastname: Nagel
authors.forename: R M
authors.initials: RM
authors.lastname: Nishikawa
authors.forename: J
authors.initials: J
authors.lastname: Papaioannou
authors.forename: K
authors.initials: K
authors.lastname: Doi
mesh_terms: D001943:Breast Neoplasms / Q000000981:diagnostic imaging; D002114:Calcinosis / Q000000981:diagnostic imaging*; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008327:Mammography; D015588:Observer Variation; D011857:Radiographic Image Interpretation, Computer-Assisted; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity