[Graft rejection in experimental xenogenic transplantation of isolated islands of Langerhans of the pig].
Prevention of the occurrence of diabetes-specific vascular complications is the final aim of clinical islet transplantation. Pancreatic islets isolated from adult pigs may be a suitable tissue source to transplant a large number of type 1 diabetic patients. Acute cellular rejection may be finally overcome by clinically applicable protocols for tolerance induction. However, primary nonfunction of the graft, as regularly observed in the porcine islet-to-rat xenotransplantation model, may be an additional problem. In this paper, species-specific inflammatory and immunological mechanisms are discussed which prevent early porcine islet graft function in rats but not in mice.
Jahr
H
H
Medizinische Klinik III und Poliklinik, Justus-Liebig-Universität Giessen.
Brandhorst
D
D
Brandhorst
H
H
Brendel
M
M
Eckhardt
T
T
el-Ouaghlidi
A
A
Hussmann
B
B
Lau
D
D
Nahidi
F
F
Wacker
T
T
Zwolinski
A
A
Bretzel
R G
RG
D000328:Adult; D000818:Animals; D003167:Complement Activation / Q000276:immunology; D016332:Fetal Tissue Transplantation / Q000276:immunology; D006084:Graft Rejection / Q000276:immunology*; D006801:Humans; D016381:Islets of Langerhans Transplantation / Q000276:immunology*; D051379:Mice; D008819:Mice, Nude; D051381:Rats; D013045:Species Specificity; D013552:Swine; D014183:Transplantation, Heterologous / Q000276:immunology*