title: Reduced renal failure following thoracoabdominal aortic aneurysm repair by selective perfusion.
abstract: OBJECTIVE
  Renal failure and visceral ischemia are feared complications following thoracoabdominal aortic aneurysm (TAAA) repair, significantly contributing to mortality. This prospective study describes volume- and pressure-controlled perfusion of the renal and visceral arteries during TAAA surgery.
  
  
  METHODS
  In 73 consecutive patients (mean age 59 years), TAAA repair (27 type I, 28 type II, 8 type III and 10 type IV) was performed, using retrograde and selective organ perfusion. Sixteen patients had impaired renal function with blood creatinine higher than 100 mmol/l. During the thoracic part of the procedure, the mean distal aortic pressure was kept above 60 mm Hg by means of left-heart bypass. After opening the abdominal aorta, the renal and visceral arteries were individually perfused by means of perfusion catheters (9 French) in the first 33 patients (group I). Volume flow through each catheter was assessed with ultrasound flow meters and maintained at least at 60 ml/min. In addition to volume flow measurements, catheters with pressure sensors were used in the last 40 patients (group II), allowing pressure-controlled selective perfusion. The extent of the aneurysm was comparable in both groups.
  
  
  RESULTS
  Mean cross-clamp time for the thoracic part was 46 min, including proximal anastomosis and reattachment of intercostal arteries. Mean cross-clamp time for the abdominal part was 74 min, including re-implantation of intestinal and renal arteries and selective dacron grafts to the celiac-axis arteries (n = 5), superior mesenteric arteries (n = 8) and renal arteries (n = 25), through which the catheters guaranteed continuous perfusion during the time the anastomosis was performed. Urine output was uninterrupted in all patients, irrespective of cross-clamp time. In group I, one patient (3%) developed renal failure and three patients (9%) required temporary peritoneal dialysis. In group II, no patients developed renal failure and two patients (5%) required temporary peritoneal dialysis. Thirteen patients with pre-existing renal impairment did not deteriorate. No patients developed visceral ischemia or multiple-organ failure. Total in-hospital mortality was 6/73 (8%) and was related to cardiopulmonary complications.
  
  
  CONCLUSIONS
  Renal and visceral ischemia can be reduced significantly by continuous perfusion during cross-clamping in TAAA repair. Not only sufficient volume flow but also adequate arterial pressure appears to be essential in maintaining renal function.
authors.affiliation: Department of Vascular Surgery, Academic Medical Center of the University of Amsterdam, The Netherlands. m.jacobs@amc.uva.nl
authors.forename: M J
authors.initials: MJ
authors.lastname: Jacobs
authors.forename: L
authors.initials: L
authors.lastname: Eijsman
authors.forename: S A
authors.initials: SA
authors.lastname: Meylaerts
authors.forename: R
authors.initials: R
authors.lastname: Balm
authors.forename: D A
authors.initials: DA
authors.lastname: Legemate
authors.forename: P
authors.initials: P
authors.lastname: de Haan
authors.forename: C J
authors.initials: CJ
authors.lastname: Kalkman
authors.forename: B A
authors.initials: BA
authors.lastname: de Mol
mesh_terms: D017544:Aortic Aneurysm, Abdominal / Q000601:surgery*; D017545:Aortic Aneurysm, Thoracic / Q000601:surgery*; D005260:Female; D018611:Heart Bypass, Left; D006801:Humans; D007430:Intraoperative Care / Q000379:methods; D007511:Ischemia / Q000517:prevention & control; D007668:Kidney / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D010477:Perfusion / Q000379:methods; D011183:Postoperative Complications / Q000453:epidemiology / Q000517:prevention & control*; D011446:Prospective Studies; D051437:Renal Insufficiency / Q000453:epidemiology / Q000517:prevention & control*; D014781:Viscera / Q000098:blood supply