title: Analgesic rebound headache in children and adolescents.
abstract: For more than a decade, the frequent use of analgesics has been recognized to lead to daily headaches in adults. To date, no studies on the occurrence of analgesic rebound headache have been done on the pediatric population. We retrospectively reviewed all charts of patients with the diagnosis of headache seen in our pediatric headache clinic between January 1996 and May 1997. Among the 98 patients seen, 46 (47%) suffered from daily or near daily headaches; 30 of them were consuming daily analgesics. Twenty-four patients (mean age 12.1 years, and mean follow-up 6.2 months) successfully discontinued their analgesics. Twenty-two patients were also placed on amitriptyline. A significant reduction in the frequency (80%), severity (47%), and number of school days missed (74%) were seen. In conclusion, this data is comparable to previous observations reported in adults, and suggests that the daily use of analgesics might result in daily or near daily headaches in the pediatric population. Discontinuing daily analgesics, with the concomitant use of amitriptyline, is an effective treatment for analgesic rebound headache in this population.
authors.affiliation: Department of Neurology and the Pediatric Headache Clinic, Vanderbilt University Medical Center, Nashville, TN 37212, USA.
authors.forename: E
authors.initials: E
authors.lastname: Vasconcellos
authors.forename: J E
authors.initials: JE
authors.lastname: Piña-Garza
authors.forename: E J
authors.initials: EJ
authors.lastname: Millan
authors.forename: J S
authors.initials: JS
authors.lastname: Warner
mesh_terms: D000293:Adolescent; D018759:Adrenergic Uptake Inhibitors / Q000627:therapeutic use; D000639:Amitriptyline / Q000627:therapeutic use; D000700:Analgesics / Q000009:adverse effects*; D002648:Child; D005260:Female; D006261:Headache / Q000139:chemically induced / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008297:Male; D012189:Retrospective Studies
chemical_list: D018759:Adrenergic Uptake Inhibitors; D000700:Analgesics; D000639:Amitriptyline