Studies on the potential for genotoxic carcinogenicity of fragrances and other chemicals.
The potential of fragrances, physiological chemicals, natural products and a group of randomly selected chemicals to induce cancers by a genotoxic mechanism (i.e. "genotoxic" carcinogenesis) was compared using structure-activity relationships (SAR) models. Fragrances are significantly less likely to induce genotoxic carcinogenicity than randomly selected chemicals or natural products. With respect to the latter potential, fragrances were indistinguishable from normal mammalian physiological constituents.
Rosenkranz
H S
HS
Department of Environmental and Occupational Health, University of Pittsburgh, PA 15238, USA.
Zhang
Y P
YP
Klopman
G
G
D000818:Animals; D015197:Carcinogenicity Tests; D002273:Carcinogens / Q000633:toxicity*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D016208:Databases, Factual; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D010476:Perfume / Q000633:toxicity*; D011237:Predictive Value of Tests; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D013329:Structure-Activity Relationship
D002273:Carcinogens; D009153:Mutagens; D010476:Perfume