title: Early localization of mRNA coding for 5-HT1A receptors in human brain during development.
abstract: The distribution of 5-HT1A receptor mRNA in the human brain was studied in neonatal, children and adult cases by means of in situ hybridization histochemistry, using an oligonucleotide derived from the coding region of the human receptor. A prenatal pattern of development was observed. The hippocampus, raphe nuclei and neocortex presented high levels of hybridization already at the fetal/neonatal stage, fully comparable to the adult. A high and transient hybridization signal was found in cerebellum. These results support a role for 5-HT1A receptors in the regulation of neural development.
authors.affiliation: Department of Physiology and Pharmacology, Unit of Pharmacology, Facultad de Medicina, Universidad de Cantabria, Avda Herrera Oria s/n, 39011, Santander, Spain.
authors.forename: E
authors.initials: E
authors.lastname: del Olmo
authors.forename: J F
authors.initials: JF
authors.lastname: López-Giménez
authors.forename: M T
authors.initials: MT
authors.lastname: Vilaró
authors.forename: G
authors.initials: G
authors.lastname: Mengod
authors.forename: J M
authors.initials: JM
authors.lastname: Palacios
authors.forename: A
authors.initials: A
authors.lastname: Pazos
mesh_terms: D001921:Brain / Q000254:growth & development* / Q000502:physiology; D001923:Brain Chemistry / Q000502:physiology*; D002531:Cerebellum / Q000737:chemistry / Q000254:growth & development; D002648:Child; D002675:Child, Preschool; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006624:Hippocampus / Q000737:chemistry / Q000254:growth & development; D006801:Humans; D017403:In Situ Hybridization; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D015345:Oligonucleotide Probes; D012333:RNA, Messenger / Q000032:analysis; D011903:Raphe Nuclei / Q000737:chemistry / Q000254:growth & development; D011985:Receptors, Serotonin / Q000235:genetics*; D044263:Receptors, Serotonin, 5-HT1
chemical_list: D015345:Oligonucleotide Probes; D012333:RNA, Messenger; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1