Sodium butyrate suppresses apoptosis in human Burkitt lymphomas and murine plasmacytomas bearing c-myc translocations.
We report that sodium butyrate, a natural product of fiber degradation by colonic bacteria, markedly suppresses c-Myc-mediated apoptosis induced in murine plasmacytomas and human Burkitt lymphomas by growth factor deprivation, but not in cell lines devoid of c-myc translocations. Attenuation of cell death is associated with downregulation of the rearranged c-myc and activation of pRb via its dephosphorylation. We suggest that in vivo sodium butyrate may play an important role in plasmacytomagenesis by supporting the survival of cells with c-myc translocations, which otherwise would be eliminated by the lack of growth factors.
Alexandrov
I
I
Division of Monoclonal Antibodies, Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20892, USA. ivan@nlando.msk.su
Romanova
L
L
Mushinski
F
F
Nordan
R
R
D000818:Animals; D017209:Apoptosis / Q000187:drug effects* / Q000235:genetics*; D002051:Burkitt Lymphoma / Q000235:genetics / Q000473:pathology*; D002087:Butyrates / Q000494:pharmacology*; D020148:Butyric Acid; D016259:Genes, myc; D006633:Histamine Antagonists / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D010954:Plasmacytoma / Q000235:genetics / Q000473:pathology*; D014178:Translocation, Genetic; D014407:Tumor Cells, Cultured
D002087:Butyrates; D006633:Histamine Antagonists; D020148:Butyric Acid