[Comparative analysis of changes in respiration and systemic hemodynamics during activation of GABA receptors in cats and rats].
Effects of alpha-hydroxybutyrate (GHB) involved a decrease in the respiration rate and subsequent periodic breathing in anesthetised cats and rats. No considerable changes occurred in systemic circulation. There were, however, some differences between the species in the patterns of respiratory arrest. Possible mechanisms of the similarity and difference are discussed.
Tarakanov
I A
IA
Research Institute of General Pathology and Pathophysiology, Russia.
Safonov
V A
VA
D000818:Animals; D002415:Cats; D005260:Female; D018755:GABA Agonists / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006885:Hydroxybutyrates / Q000494:pharmacology; D008297:Male; D009942:Organometallic Compounds / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D018079:Receptors, GABA / Q000187:drug effects* / Q000502:physiology; D012119:Respiration / Q000187:drug effects* / Q000502:physiology; D012131:Respiratory Insufficiency / Q000139:chemically induced / Q000503:physiopathology; D013045:Species Specificity
D018755:GABA Agonists; D006885:Hydroxybutyrates; D009942:Organometallic Compounds; D018079:Receptors, GABA; C022826:lithium hydroxybutyrate; C031570:2-hydroxybutyric acid