title: Chromosome band 1q21 is recurrently gained in desmoid tumors.
abstract: DNA sequence copy number changes were studied by comparative genomic hybridization (CGH) in 28 desmoid tumors. Changes were detected in 12 tumors (43%) with a mean of 1.4 changes per sample (range: 1 to 7). Out of 12 tumors associated with pregnancy or Gardner's syndrome, only two displayed changes. The minimal common regions of the most frequent gains were 1q21 (39%), chromosome 20 (32%), and 9p12 (21%). No high-level amplifications were detected. Losses of DNA sequences were two times less frequent than gains and the minimal common regions of the most frequent losses were 6q16-q21 (14%), 5q14 (11%), and 13q21-q31 (11%).
authors.affiliation: Department of Medical Genetics, Haartman Institute, University of Helsinki, Finland.
authors.forename: M L
authors.initials: ML
authors.lastname: Larramendy
authors.forename: M
authors.initials: M
authors.lastname: Virolainen
authors.forename: E
authors.initials: E
authors.lastname: Tukiainen
authors.forename: I
authors.initials: I
authors.lastname: Elomaa
authors.forename: S
authors.initials: S
authors.lastname: Knuutila
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002869:Chromosome Aberrations / Q000235:genetics*; D002871:Chromosome Banding; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D005260:Female; D018222:Desmoid Tumors / Q000235:genetics*; D005784:Gene Amplification / Q000235:genetics; D018628:Gene Dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization