title: Nutrition and osteoporosis.
abstract: Nutritional factors have a significant influence on the cause of osteoporosis. Calcium supplementation may be particularly effective in populations with a low calcium diet. Supplementations of 500 mg/d may produce about 4% gain in skeletal calcium in adolescents. Supplementations of 800 mg/d may prevent bone loss in postmenopausal women. The results of clinical trials also suggested that such supplementation may prevent hip and vertebral fractures in the elderly. The largest effect of calcium supplementation occurs in the first year of treatment, whereas sustained effects are not proven. Vitamin D supplementation may be particularly useful in vitamin D-deficient elderly. In this group, hip fractures may be prevented by vitamin D administration. Urinary sodium excretion is correlated with urinary calcium excretion in humans, and a direct effect of high sodium intake on loss at the hip has been demonstrated. Observational epidemiologic studies suggested a negative effect of a high protein intake on bone density, although there are no results from clinical trials to support this view. Dietary fiber, phytate, oxalate, and caffeine intake may have a small negative effect on calcium absorption.
authors.affiliation: Department of Community & Family Medicine, Chinese University of Hong Kong, Shatin, N.T., Hong Kong.
authors.forename: E M
authors.initials: EM
authors.lastname: Lau
authors.forename: J
authors.initials: J
authors.lastname: Woo
mesh_terms: D000367:Age Factors; D002118:Calcium / Q000652:urine; D002136:Calcium, Dietary / Q000008:administration & dosage; D004044:Dietary Proteins / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008297:Male; D009747:Nutritional Physiological Phenomena / Q000502:physiology*; D010024:Osteoporosis / Q000097:blood / Q000503:physiopathology* / Q000652:urine; D017698:Postmenopause; D012982:Sodium, Dietary / Q000008:administration & dosage; D014807:Vitamin D / Q000097:blood
chemical_list: D002136:Calcium, Dietary; D004044:Dietary Proteins; D012982:Sodium, Dietary; D014807:Vitamin D; D002118:Calcium