Transgenic fish and its application in basic and applied research.
Since 1985, transgenic fish have been successfully produced by microinjecting or electroporating desired foreign DNA into unfertilized or newly fertilized eggs using many different fish species. More recently, transgenic fish have also been produced by infecting newly fertilized eggs with pantropic, defective retroviral vectors carrying desired foreign DNA. These transgenic fish can serve as excellent experimental models for basic scientific investigations as well as in biotechnological applications. In this paper, we will review the current status of the transgenic fish research and its potential application in basic and applied research.
Chen
T T
TT
Biotechnology Center, University of Connecticut, Storrs, USA.
Vrolijk
N H
NH
Lu
J K
JK
Lin
C M
CM
Reimschuessel
R
R
Dunham
R A
RA
D000818:Animals; D030801:Animals, Genetically Modified / Q000235:genetics*; D001709:Biotechnology / Q000379:methods*; D018274:Electroporation; D004784:Environmental Monitoring; D005399:Fishes / Q000235:genetics*; D018014:Gene Transfer Techniques; D005822:Genetic Vectors; D013006:Growth Hormone / Q000235:genetics; D007334:Insulin-Like Growth Factor I / Q000235:genetics; D008845:Microinjections; D012107:Research Design
D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone