title: Obesity and reproductive disorders: a review.
abstract: Obesity has significant consequences for the reproductive system, depending upon the amount and distribution of body fat. Epidemiological evidence clearly shows that being overweight contributes to menstrual disorders, infertility, miscarriage, poor pregnancy outcome, impaired fetal well-being and diabetes mellitus. Central adiposity is particularly important in clinical sequelae associated with an increased body mass index. The advent of assisted reproduction highlights the problems of being overweight, and the use of gonadotrophins in ovulation induction and in vitro fertilization is more difficult when the subject is overweight. Weight loss has marked effects on improving the menstrual cycle and promoting spontaneous ovulation and fertility. Results indicate that fertility is improved through exercise and sensible eating patterns when conducted in a group environment. The mechanisms for this are unclear but may be associated with changes in sensitivity to insulin.
authors.affiliation: Department of Obstetrics and Gynaecology, The University of Adelaide, The Queen Elizabeth Hospital, Woodville, SA, Australia. rnorman@medicine.adelaide.edu.au
authors.forename: R J
authors.initials: RJ
authors.lastname: Norman
authors.forename: A M
authors.initials: AM
authors.lastname: Clark
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology; D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D000368:Aged; D000728:Androgens / Q000378:metabolism; D004967:Estrogens / Q000378:metabolism; D005260:Female; D018149:Glucose Intolerance; D006801:Humans; D007247:Infertility, Female / Q000209:etiology*; D008297:Male; D008599:Menstruation Disturbances / Q000209:etiology*; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000378:metabolism; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D015431:Weight Loss
chemical_list: D000728:Androgens; D004967:Estrogens