title: New types of liposidomycins that inhibit bacterial peptidoglycan synthesis and are produced by Streptomyces. I. Producing organism and medium components.
abstract: Liposidomycins are atypical lipid-bearing nucleoside antibiotics that inhibit bacterial peptidoglycan synthesis. A producing strain was identified as a Streptomyces sp. from its cultural characteristics and physiological properties. It produced new types of liposidomycins that lacked sulfate and/or 3-methylglutaric acid moieties present in known liposidomycins by changing medium components. Sucrose and malt extract were particularly suitable sources for specific production of the new types of liposidomycins.
authors.affiliation: Research Institute of Life Science, Snow Brand Milk Products Co., Ltd., Tochigi, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kimura
authors.forename: S
authors.initials: S
authors.lastname: Kagami
authors.forename: Y
authors.initials: Y
authors.lastname: Ikeda
authors.forename: H
authors.initials: H
authors.lastname: Takahashi
authors.forename: M
authors.initials: M
authors.lastname: Yoshihama
authors.forename: H
authors.initials: H
authors.lastname: Kusakabe
authors.forename: H
authors.initials: H
authors.lastname: Osada
authors.forename: K
authors.initials: K
authors.lastname: Isono
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D003470:Culture Media; D009168:Mycobacterium phlei / Q000187:drug effects; D010457:Peptidoglycan / Q000096:biosynthesis*; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D003470:Culture Media; D010457:Peptidoglycan; C047544:liposidomycins