title: Severe alopecia areata treated with systemic corticosteroids.
abstract: BACKGROUND
  Treatment of severe alopecia areata is difficult, and most efforts to successfully treat this condition have been disappointing. Systemic corticosteroids have been demonstrated as an effective treatment of severe alopecia areata.
  
  
  METHODS
  Eighteen patients with alopecia areata (extensive patchy and totalis universalis types) were treated with systemic corticosteroids.
  
  
  RESULTS
  Satisfactory hair regrowth was achieved in seven patients (38.9%). Hair fall subsequently occurred in all of these patients on discontinuation or tapering of corticosteroid therapy.
  
  
  CONCLUSIONS
  Systemic corticosteroid therapy does not prevent the spread or relapse of severe alopecia areata and, when complete regrowth is obtained, it is rarely maintained off therapy.
authors.affiliation: Department of Dermatology, King Fahd Hospital of the University, Dammam, Saudi Arabia.
authors.forename: A S
authors.initials: AS
authors.lastname: Alabdulkareem
authors.forename: A A
authors.initials: AA
authors.lastname: Abahussein
authors.forename: A
authors.initials: A
authors.lastname: Okoro
mesh_terms: D000293:Adolescent; D000328:Adult; D000506:Alopecia Areata / Q000188:drug therapy* / Q000503:physiopathology; D002648:Child; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006197:Hair / Q000502:physiology; D006801:Humans; D008297:Male; D011241:Prednisone / Q000627:therapeutic use*
chemical_list: D005938:Glucocorticoids; D011241:Prednisone