Deciphering cryptic similarities in protein binding sites.
Rapid expansion in the number of plausible drug targets arising from genomics research has created new pressures for increased efficiency in discovery of high specificity candidate drug compounds. Improved understanding of conserved features among protein structures provides a promising route to achieving this goal. Indirect evidence implies that important similarities are now ripe for elucidation by emerging experimental approaches.
Kauvar
LM
Terrapin Technologies, Inc 750 Gateway Blvd, South San Francisco, CA 94080, USA kauvarlm@earthlink.net
Villar
HO