title: Brain infarction following 5-fluorouracil and cisplatin therapy.
abstract: Five patients with oropharyngeal cancer treated with 5-fluorouracil and cisplatin had ischemic stroke within 2 to 5 days after the drug infusion. This occurred during the second course of chemotherapy in three patients, and during the third course in two patients. There may be a relation between treatment and brain infarction because 1) there was no other cause identified despite extensive tests, including postmortem examination in one patient; 2) there was a short delay between treatment infusion and stroke; and 3) there was a similar pattern of ischemic stroke after the second or third course of chemotherapy.
authors.affiliation: Department of Neurology, Saint-Antoine Hospital, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: El Amrani
authors.forename: O
authors.initials: O
authors.lastname: Heinzlef
authors.forename: T
authors.initials: T
authors.lastname: Debroucker
authors.forename: E
authors.initials: E
authors.lastname: Roullet
authors.forename: M G
authors.initials: MG
authors.lastname: Bousser
authors.forename: P
authors.initials: P
authors.lastname: Amarenco
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D002544:Cerebral Infarction / Q000139:chemically induced*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000188:drug therapy
chemical_list: D002945:Cisplatin; D005472:Fluorouracil