title: The gallium-deferoxamine complex: stability with different deferoxamine concentrations and incubation conditions.
abstract: Previous studies report that deferoxamine (DFO) binds metallic ions such as Fe3+, In3+ and Ga3+ with very high affinity. This property of DFO has been utilized to label DFO-coupled compounds with radiometals such as 67Ga and 111In. We have studied the effect of low DFO concentrations and of different incubation conditions on the stability of the 67Ga-DFO complex. In our experience high (> 5 microM) DFO concentration appears to be critical in obtaining high radiochemical purity of such complexes.
authors.affiliation: Positron Emission Tomography Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
authors.forename: C
authors.initials: C
authors.lastname: Caraco
authors.forename: L
authors.initials: L
authors.lastname: Aloj
authors.forename: W C
authors.initials: WC
authors.lastname: Eckelman
mesh_terms: D002855:Chromatography, Thin Layer; D003676:Deferoxamine / Q000737:chemistry*; D005708:Gallium / Q000737:chemistry; D005710:Gallium Radioisotopes / Q000737:chemistry*
chemical_list: D005710:Gallium Radioisotopes; C034163:gallium chloride; D005708:Gallium; D003676:Deferoxamine