Dent's disease--the hypercalciuric variant of Fanconi's syndrome.
Dent's disease is a rare type of proximal renal tubular defect characterized by hypercalciuria, low-molecular-weight (LMW) proteinuria, nephrocalcinosis and slowly progressive renal failure, short stature and osteopenia in children with clinical symptoms of rickets. This "hypercalciuric rickets" was originally described by Charles Dent and Max Friedman in 1964 [1]. The disease is probably linked to the X chromosome so that males are much more severely affected than females.
Kabícek
P
P
Department of Pediatrics, 1st Faculty of Medicine, Charles University, Praha, Czech Republic.
Bayer
M
M
D000293:Adolescent; D002118:Calcium / Q000652:urine*; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000150:complications; D005198:Fanconi Syndrome / Q000150:complications / Q000652:urine*; D006801:Humans; D008297:Male; D011507:Proteinuria
D002118:Calcium