Serum sCD23 in patients with lepromatous and tuberculoid leprosy.
Tuberculoid and lepromatous leprosy (TL and LL) manifest exaggerated Th1 and Th2 type immunity, respectively. Serum soluble CD23, which is regulated by the stimulatory action of IL4 and inhibitory action of IFNgamma, was significantly elevated in LL relative to TL and healthy controls. These results confirm the state of cellular and humoral immunity in TL and LL.
Bansal
A S
AS
Department of Immunology, St Helier NHS Trust, Carshalton, Surrey, UK.
Bruce
J
J
Wilson
P B
PB
Anyiwo
C E
CE
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D015440:Leprosy, Lepromatous / Q000276:immunology*; D015441:Leprosy, Tuberculoid / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D017455:Receptors, IgE / Q000097:blood*; D012016:Reference Values; D012680:Sensitivity and Specificity; D012995:Solubility
D017455:Receptors, IgE