Correlation between human papillomavirus DNA detection in maternal cervical smears and buccal swabs of infants.
Acquisition of human papillomavirus (HPV) infection in buccal mucosa by the infants at birth has been investigated. Presence of HPV DNA was evaluated in cervical smears of 30 pregnant women before delivery and in buccal swabs of the corresponding 31 infants (1 set of twins). HPV DNA was detected among the 40% of women, 16% of infants an the detection was concordant in 23 mother-infant pairs. HPV DNA was demonstrated in buccal mucosal cells of 41.6% of the infants born to HPV positive mothers. Maternal-infant transmission was highest for HPV 6/11. Assessment of the risk of developing HPV related oral lesions in children at later life owing to acquisition of HPV during perinatal period may help in determining a strategy to combat the disease.
Chatterjee
R
R
Department of Tumor Virology, Chittarajan National Cancer Institute, Calcutta, India.
Mukhopadhyay
D
D
Murmu
N
N
Mitra
P K
PK
D002610:Cheek; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D009061:Mouth Mucosa / Q000821:virology*; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D011247:Pregnancy; D014626:Vaginal Smears
D004279:DNA, Viral