title: Posttreatment with low molecular weight heparin reduces brain edema and infarct volume in rats subjected to thrombotic middle cerebral artery occlusion.
abstract: Low molecular weight heparin (LMWH) has similar efficacy to unfractionated heparin with less hemorrhagic complications. We studied the neuroprotective effect of LMWH on a rat model of focal-ischemia. Our results revealed that treatment with LMWH at 1 and 3 h following thrombotic MCA occlusion reduced brain edema and infarct size and improved clinical outcome. Treatment with LMWH initiated at 6 h after thrombin injection only partially ameliorated brain damage.
authors.affiliation: Department of Medicine (Neurology), The University of Alberta Hospital, Stroke Research Centre and The Saskatchewan Stroke Research Centre, Saskatoon, Canada.
authors.forename: P A
authors.initials: PA
authors.lastname: Li
authors.forename: Q P
authors.initials: QP
authors.lastname: He
authors.forename: M M
authors.initials: MM
authors.lastname: Siddiqui
authors.forename: A
authors.initials: A
authors.lastname: Shuaib
mesh_terms: D000818:Animals; D001929:Brain Edema / Q000188:drug therapy*; D002545:Brain Ischemia / Q000188:drug therapy; D002539:Cerebral Arterial Diseases / Q000503:physiopathology*; D002544:Cerebral Infarction / Q000188:drug therapy*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage / Q000494:pharmacology*; D007279:Injections, Subcutaneous; D002542:Intracranial Embolism and Thrombosis / Q000188:drug therapy*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D006495:Heparin, Low-Molecular-Weight