title: [The good use of antibiotics in intensive care: results of a program for rationalization of prescriptions].
abstract: OBJECTIVE
  To assess the impact of an antibiotic prescribing programme in a intensive therapy unit.
  
  
  METHODS
  Prospective comparative study.
  
  
  METHODS
  We compared antibiotic prescriptions and bacterial susceptibility to antimicrobial agents before and after introduction of a programme focusing on injection control and therapeutic indications.
  
  
  RESULTS
  The introduction of the programme resulted in a major decrease in antibiotic administration. Moreover, the susceptibility of Pseudomonas aeruginosa to ticarcillin increased from 40 to 68%, and susceptibility of Staphylococcus aureus to methicillin increased from 55 to 73%.
  
  
  CONCLUSIONS
  Antibiotic control policies must be considered integral to any effort to decrease resistance and cost of therapy with antibiotics.
authors.affiliation: Service de réanimation, hôpital Edouard-Herriot, Lyon, France.
authors.forename: I
authors.initials: I
authors.lastname: Mohammedi
authors.forename: S
authors.initials: S
authors.lastname: Duperret
authors.forename: J M
authors.initials: JM
authors.lastname: Védrinne
authors.forename: B
authors.initials: B
authors.lastname: Allaouchiche
authors.forename: B
authors.initials: B
authors.lastname: Bui-Xuan
authors.forename: P
authors.initials: P
authors.lastname: Boulétreau
mesh_terms: D000900:Anti-Bacterial Agents / Q000191:economics / Q000627:therapeutic use*; D003422:Critical Care / Q000191:economics / Q000592:standards*; D011307:Drug Prescriptions / Q000191:economics / Q000592:standards*; D004363:Drug Utilization; D005260:Female; D005602:France; D006801:Humans; D008297:Male; D008712:Methicillin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010406:Penicillins / Q000494:pharmacology; D011446:Prospective Studies; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012151:Resuscitation; D013211:Staphylococcus aureus / Q000187:drug effects; D013982:Ticarcillin / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D010406:Penicillins; D013982:Ticarcillin; D008712:Methicillin