title: Thyroid scintigraphy in children with hypothyroidism: a five-year experience.
abstract: The presence or absence of thyroid glandular tissue demonstrated by thyroid scintigraphy is important for genetic and prognostic counseling and for acceleration of diagnosis in other affected siblings. Technetium-99m-pertechnetate thyroid scintigraphy was performed on 27 children with cretinism at the Division of Nuclear Medicine, Faculty of Medicine Siriraj Hospital during the 5-year period from June 1991. Based on scintigraphic findings, three main groups of thyroid localization were seen. Thirteen (48.1%) were athyrotic while 3 (11.1%) had an ectopic thyroid and 11 (40.8%) had gland in normal position. Perchlorate discharge test was performed in 8 children of the last group and the results were positive indicating an organification defect. Thyroid scintigraphy and perchlorate discharge test provided the useful information for diagnosis, follow-up, and prognosis in children with cretinism.
authors.affiliation: Department of Radiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: P
authors.initials: P
authors.lastname: Pusuwan
authors.forename: S
authors.initials: S
authors.lastname: Likitmaskul
authors.forename: S
authors.initials: S
authors.lastname: Wacharasindhu
authors.forename: S
authors.initials: S
authors.lastname: Intarasupht
authors.forename: V
authors.initials: V
authors.lastname: Attanatho
authors.forename: J
authors.initials: J
authors.lastname: Mungkharak
authors.forename: S
authors.initials: S
authors.lastname: Chiewvit
authors.forename: R
authors.initials: R
authors.lastname: Pleehachinda
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003409:Congenital Hypothyroidism / Q000175:diagnosis / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007037:Hypothyroidism / Q000150:complications / Q000000981:diagnostic imaging*; D008297:Male; D011877:Radionuclide Imaging; D013670:Sodium Pertechnetate Tc 99m; D013961:Thyroid Gland / Q000000981:diagnostic imaging*
chemical_list: D013670:Sodium Pertechnetate Tc 99m