title: Silicone oil in the repair of complex retinal detachments. A prospective observational multicenter study.
abstract: OBJECTIVE
  This study aimed to report anatomic and visual acuity outcomes and complications after 1000-centistoke silicone oil was used as a retinal tamponade for the treatment of complex retinal detachments.
  
  
  METHODS
  Prospective observational multicenter study conducted at community and university-based ophthalmology clinics.
  
  
  METHODS
  The study cohort consisted of 2439 patients (2573 eyes) treated for complex retinal detachments associated with cytomegalovirus (CMV) necrotizing retinitis or a non-CMV etiology, including proliferative diabetic retinopathy, giant retinal tears, proliferative vitreoretinopathy, or ocular trauma.
  
  
  METHODS
  Vitrectomy surgery was performed for complex retinal detachment with 1000-centistoke silicone oil as the retinal tamponade.
  
  
  METHODS
  Anatomic outcomes were complete retinal attachment and macular attachment. Visual acuity outcomes were ambulatory vision (> or = 4/200) and preservation of preoperative visual acuity. Complications were rates of secondary intraocular pressure elevation (> or = 30 mmHg), hypotony (< or = 5 mmHg), corneal opacification (including band keratopathy, corneal edema, and corneal abrasions), oil emulsification, and cataract. Outcomes were assessed 6, 12, and 24 months after surgery.
  
  
  RESULTS
  At the 6-month examination, the retina was completely attached in 178 (78%) of 228 CMV eyes and in 855 (70%) of 1219 non-CMV eyes. The macula was attached in 216 (95%) of 228 and 1062 (89%) of 1189 CMV and non-CMV eyes, respectively. Ambulatory vision was noted in 151 (65%) of 234 CMV eyes and in 480 (38%) of 1251 non-CMV eyes. Visual acuity was preserved in 106 (46%) of 230 and 1035 (84%) of 1229 CMV and non-CMV eyes, respectively. The corresponding rates of complications for CMV and non-CMV eyes were: elevated intraocular pressure, 0 (0%) of 196 and 35 (3%) of 1196; hypotony, 11 (6%) of 196 and 228 (19%) of 1196; corneal opacity, 13 (6%) of 229 and 326 (26%) of 1248; emulsification, 3 (1%) of 211 and 29 (3%) of 959; and cataract in phakic eyes, 118 (64%) of 185 and 50 (63%) of 80.
  
  
  CONCLUSIONS
  Retinal reattachment was achieved in the majority of eyes using vitrectomy and silicone oil retinal tamponade. Complication rates generally were less frequent in CMV eyes, but follow-up was shorter in this group of patients, largely because of reduced life expectancy. Cataract frequently developed in phakic eyes of study patients. Use of 1000-centistoke silicone oil can be considered in the management of complex retinal detachments associated with multiple etiologies.
authors.affiliation: Department of Preventive Medicine, University of Southern California, Los Angeles 90033, USA.
authors.forename: S P
authors.initials: SP
authors.lastname: Azen
authors.forename: I U
authors.initials: IU
authors.lastname: Scott
authors.forename: H W
authors.initials: HW
authors.lastname: Flynn
authors.forename: M Y
authors.initials: MY
authors.lastname: Lai
authors.forename: T M
authors.initials: TM
authors.lastname: Topping
authors.forename: L
authors.initials: L
authors.lastname: Benati
authors.forename: D K
authors.initials: DK
authors.lastname: Trask
authors.forename: L A
authors.initials: LA
authors.lastname: Rogus
mesh_terms: D000328:Adult; D015331:Cohort Studies; D017726:Cytomegalovirus Retinitis / Q000150:complications; D005131:Eye Injuries / Q000150:complications; D005260:Female; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012163:Retinal Detachment / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D012164:Retinal Diseases / Q000150:complications; D012827:Silicone Oils / Q000008:administration & dosage* / Q000009:adverse effects; D016896:Treatment Outcome; D014792:Visual Acuity; D014821:Vitrectomy
chemical_list: D012827:Silicone Oils