title: Ion-channel-forming colicins.
abstract: Several features of ion-channel-forming colicins have been illuminated by recent revelations: its four-domain structure, the mechanism and thermodynamics of binding to the gating loop of outer membrane porins, the mechanism of translocation, competition for the transperiplasmic excursion facilitated by the Tol or Ton transperiplasmic proteins, and the formation of a waisted, funnel-shaped transmembrane channel of well-characterized shape.
authors.affiliation: Department of Biochemistry and Biophysics, University of California, San Francisco School of Medicine 94143-0448, USA. stroud@msg.ucsf.edu
authors.forename: R M
authors.initials: RM
authors.lastname: Stroud
authors.forename: K
authors.initials: K
authors.lastname: Reiling
authors.forename: M
authors.initials: M
authors.lastname: Wiener
authors.forename: D
authors.initials: D
authors.lastname: Freymann
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism; D001667:Binding, Competitive; D003087:Colicins / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D007473:Ion Channels / Q000737:chemistry / Q000378:metabolism*; D008954:Models, Biological; D018272:Porins / Q000378:metabolism; D017433:Protein Structure, Secondary
chemical_list: D001426:Bacterial Proteins; D003087:Colicins; D007473:Ion Channels; D018272:Porins; C007104:colicin immunity proteins