title: Chondrocalcinosis of the hyaline cartilage of the knee: MRI manifestations.
abstract: OBJECTIVE
  To determine the ability of MRI to detect the presence of crystals of calcium pyrophosphate in the articular cartilage of the knee.
  
  
  METHODS
  The MR studies of 12 knees (11 cases) were reviewed retrospectively and correlated with radiographs (12 cases) and the findings at arthroscopy (2 cases) and surgery (1 case). A total of 72 articular surfaces were evaluated. Radiographic, surgical or arthroscopic demonstration of chondrocalcinosis was used as the gold standard. Additionally, two fragments of the knee of a patient who underwent total knee replacement and demonstrated extensive chondrocalcinosis were studied with radiography and MRI using spin-echo T1-, T2- and proton-density-weighted images as well as two- and three-dimensional fat saturation (2D and 3D Fat Sat) gradient recalled echo (GRE) and STIR sequences.
  
  
  RESULTS
  MRI revealed multiple hypointense foci within the articular cartilage in 34 articular surfaces, better shown on 2D and 3D GRE sequences. Radiographs showed 12 articular surfaces with chondrocalcinosis. In three cases with arthroscopic or surgical correlation, MRI demonstrated more diffuse involvement of the articular cartilage than did the radiographs. The 3D Fat Sat GRE sequences were the best for demonstrating articular calcification in vitro. In no case was meniscal calcification identified with MRI. Hyperintense halos around some of the calcifications were seen on the MR images.
  
  
  CONCLUSIONS
  MRI can depict articular cartilage calcification as hypointense foci using GRE techniques. Differential diagnosis includes loose bodies, post-surgical changes, marginal osteophytes and hemosiderin deposition.
authors.affiliation: Department of Radiology, Hospital for Joint Diseases, New York, NY 10003, USA.
authors.forename: J
authors.initials: J
authors.lastname: Beltran
authors.forename: E
authors.initials: E
authors.lastname: Marty-Delfaut
authors.forename: J
authors.initials: J
authors.lastname: Bencardino
authors.forename: Z S
authors.initials: ZS
authors.lastname: Rosenberg
authors.forename: G
authors.initials: G
authors.lastname: Steiner
authors.forename: F
authors.initials: F
authors.lastname: Aparisi
authors.forename: M
authors.initials: M
authors.lastname: Padrón
mesh_terms: D000328:Adult; D000368:Aged; D002358:Cartilage, Articular / Q000473:pathology*; D002805:Chondrocalcinosis / Q000000981:diagnostic imaging / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012189:Retrospective Studies