title: Somatostatin-receptor-negative carcinoid tumour responsible for Cushing's syndrome.
abstract: A 30-year-old man presenting with Cushing's syndrome was admitted in 1995. A diagnosis of ectopically ACTH-secreting, primary-unknown abdominal carcinoid tumour was made. The patient's plasma ACTH and cortisol levels failed to decrease after short-term treatment with octreotide, and somatostatin-receptor scintigraphy did not show any accumulation in the tumour. The patient died 1 year after admission. This is a relatively rare somatostatin-receptor-negative case of this disease and it appears necessary to test for the presence of somatostatin receptors before treating with octreotide.
authors.affiliation: First Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Takami
authors.forename: Y
authors.initials: Y
authors.lastname: Ogino
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
authors.forename: A
authors.initials: A
authors.lastname: Kubo
mesh_terms: D000008:Abdominal Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D000368:Aged; D002276:Carcinoid Tumor / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism / Q000556:secondary; D003480:Cushing Syndrome / Q000209:etiology* / Q000378:metabolism; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D009382:Neoplasms, Unknown Primary / Q000378:metabolism; D017481:Receptors, Somatostatin / Q000378:metabolism*
chemical_list: D017481:Receptors, Somatostatin