title: Malignancy in pigmented villonodular synovitis.
abstract: Malignant pigmented villonodular synovitis is an extremely rare and controversial disease. We describe malignant change in pigmented villonodular synovitis of the ankle in a patient with an unusually long clinical history. Symptoms began at age 21, metastatic disease developed at age 85, and the patient died 1 year later. The histologic appearance of the malignant tumor differed from that in most reported cases, in that spindle-shaped cells predominated. Lymph node metastasis also developed, a feature uncommon to soft tissue sarcomas.
authors.affiliation: Department of Pathology, Sarah Network of Hospitals for the Locomotor System, Brasilia, D.F., Brazil.
authors.forename: R K
authors.initials: RK
authors.lastname: Kalil
authors.forename: K K
authors.initials: KK
authors.lastname: Unni
mesh_terms: D000328:Adult; D000843:Ankle Joint / Q000473:pathology*; D001859:Bone Neoplasms / Q000473:pathology*; D002471:Cell Transformation, Neoplastic; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D011859:Radiography; D013586:Synovitis, Pigmented Villonodular / Q000000981:diagnostic imaging / Q000473:pathology*; D013977:Tibia / Q000473:pathology*; D013997:Time Factors