Helicobacter pylori-positive gastritis in pediatric patients with chronic inflammatory bowel disease.
BACKGROUND
Gastritis is a common finding in patients with inflammatory bowel disease. However, the association of gastritis with Helicobacter pylori is unclear in these patients.


METHODS
The prevalence of antibodies for H. pylori in serum was determined in 47 pediatric patients with inflammatory bowel disease (19 with Crohn's disease, 21 with ulcerative colitis, and 7 with unclassified disease). H. pylori antibodies of the IgG and IgA classes were measured by enzyme immunoassay in 24 patients at the time of diagnosis of inflammatory bowel disease and in 23 more patients during the follow-up of inflammatory bowel disease (mean follow-up, 3.5 years; range 1-10 years). Esophagogastroduodenoscopy was performed on 40 patients during the examination for inflammatory bowel disease.


RESULTS
In contrast to earlier findings, no patient was determined to be positive for H. pylori, either in serologic or histologic examination. This negative finding was unexpected, because it is known that approximately 10% of asymptomatic Finnish children have antibodies for H. pylori in serum and approximately 10% of analyses of specimens obtained in gastric antral biopsies obtained at the Hospital for Children and Adolescents, Helsinki, Finland, are positive for H. pylori.


CONCLUSIONS
Permanent colonization of the stomach with H. pylori is unusual in children with inflammatory bowel disease.
Kolho
K L
KL
Hospital for Children and Adolescents, Helsinki University Central Hospital, Finland.
Rautelin
H
H
Lindahl
H
H
Savilahti
E
E
D000293:Adolescent; D000907:Antibodies, Bacterial / Q000097:blood; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D016145:Endoscopy, Digestive System; D005260:Female; D005756:Gastritis / Q000382:microbiology* / Q000473:pathology; D005773:Gastroscopy; D016481:Helicobacter Infections / Q000382:microbiology; D016480:Helicobacter pylori / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D015212:Inflammatory Bowel Diseases / Q000382:microbiology* / Q000473:pathology; D008297:Male
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G