[SeHCAT scanning in bile acid malabsorption].
Chronic diarrhea caused by bile acid malabsorption (BAM) is usually divided into three groups. Type 1 is associated with ileal disease or ileal resection; type 2 is idiopathic, and type 3 is BAM associated with certain predisposing conditions. We evaluated the applicability of the SeHCAT test as a routine investigation of different types of suspected BAM. Detailed information about 298 patients were obtained from retrospective review of patient records. All 68 patients with ileal resections had abnormal SeHCAT retention (median 0.6%; range 0-13%). Of 42 patients with non-resected Crohn's disease or radiation injury, BAM was found in 28 cases. A diagnosis of BAM type 2 was established in 33 of 150 patients with unexplained chronic diarrhoea. For patients tested for possible BAM type 3, the SeHCAT values were significantly lower compared to type 2 patients. For BAM type 1, the SeHCAT test is only recommended in non-resected patients. Idiopathic BAM seems to be more common than recognized. The presence of certain predisposing conditions might strengthen the indication for SeHCAT testing.
Thomsen
L H
LH
Aalborg Sygehus, medicinsk gastroenterologisk afdeling.
Arveschough
A K
AK
Gustenhoff
P
P
Qvist
P
P
D000293:Adolescent; D000328:Adult; D000368:Aged; D001647:Bile Acids and Salts / Q000378:metabolism*; D002908:Chronic Disease; D003937:Diagnosis, Differential; D003967:Diarrhea / Q000175:diagnosis* / Q000378:metabolism; D005260:Female; D006801:Humans; D007077:Ileal Diseases / Q000175:diagnosis / Q000378:metabolism; D007410:Intestinal Diseases / Q000175:diagnosis / Q000378:metabolism; D008286:Malabsorption Syndromes / Q000175:diagnosis* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012644:Selenium Radioisotopes; D013656:Taurocholic Acid
D001647:Bile Acids and Salts; D012644:Selenium Radioisotopes; D013656:Taurocholic Acid