Gabapentin in orthostatic tremor: results of a double-blind crossover with placebo in four patients.
We treated four patients affected by orthostatic tremor (OT) with gabapentin in increasing doses (300 to 2,400 mg/d). OT was evaluated with patients' self-monitoring scales, tremor rating scales, electromyography (EMG) showing the 14- to 18-Hz frequencies, and EMG frequency analysis. All patients had transitory responses to clonazepam. Gabapentin induced disappearance of OT in three patients and consistent reduction in one. Crossover to placebo induced reappearance of tremor.
Onofrj
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Department of Oncology and Neuroscience, University G. D'Annunzio Chieti, Italy.
Thomas
A
A
Paci
C
C
D'Andreamatteo
G
G
D000085:Acetates / Q000009:adverse effects / Q000494:pharmacology*; D000368:Aged; D000588:Amines; D000927:Anticonvulsants / Q000009:adverse effects / Q000494:pharmacology*; D018592:Cross-Over Studies; D003509:Cyclohexanecarboxylic Acids; D004311:Double-Blind Method; D004576:Electromyography; D005260:Female; D000077206:Gabapentin; D006801:Humans; D008297:Male; D011187:Posture; D016896:Treatment Outcome; D014202:Tremor / Q000188:drug therapy*; D005680:gamma-Aminobutyric Acid
D000085:Acetates; D000588:Amines; D000927:Anticonvulsants; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin