Influence of lipid composition on pediocin PA-1 binding to phospholipid vesicles.
Pediocin PA-1 bound to anionic lipid vesicles with saturated or unsaturated fatty acid chains in a lipid concentration-dependent fashion. Little change in binding parameters was observed for zwitterionic lipid vesicles. Decreasing the anionic lipid content of the vesicles gave a higher relative dissociation constant for the peptide-lipid interactions and further supports the electrostatic interaction model of binding.
Chen
Y
Y
Department of Food Science, Cook College, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901, USA.
Ludescher
R D
RD
Montville
T J
TJ
D001430:Bacteriocins / Q000737:chemistry / Q000378:metabolism*; D001665:Binding Sites; D005227:Fatty Acids / Q000032:analysis*; D008081:Liposomes / Q000737:chemistry* / Q000378:metabolism*; D000070017:Pediocins; D010743:Phospholipids / Q000032:analysis*; D011485:Protein Binding
D001430:Bacteriocins; D005227:Fatty Acids; D008081:Liposomes; D000070017:Pediocins; D010743:Phospholipids; C074288:pediocin PA-1