title: Antibody engineering.
abstract: Among the most important advances in antibody engineering of this past year is the advent of new tools to study the relationship between protein (including antibody) structure and function. Very rapid large-scale mutational analysis of antibodies is now possible by using in vitro transcription and translation. Ribosome display is a rapidly evolving technology for modifying antibody function that offers several potential advantages over phage display.
authors.affiliation: Department of Molecular Oncology, Genentech Incorporated, South San Francisco, CA 94080, USA.
authors.forename: W
authors.initials: W
authors.lastname: Dall'Acqua
authors.forename: P
authors.initials: P
authors.lastname: Carter
mesh_terms: D000818:Animals; D000906:Antibodies / Q000737:chemistry / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D000915:Antibody Affinity; D000918:Antibody Specificity; D006801:Humans; D007128:Immunoglobulin Fragments / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D007135:Immunoglobulin Variable Region / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D019151:Peptide Library; D015202:Protein Engineering; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000276:immunology / Q000493:pharmacokinetics; D012270:Ribosomes
chemical_list: D000906:Antibodies; D007128:Immunoglobulin Fragments; D007135:Immunoglobulin Variable Region; D019151:Peptide Library; D011994:Recombinant Proteins