title: Antibiotic-impregnated xenografts in the treatment of chronic osteomyelitic cavities. Seven cases followed for 3 to 5 years.
abstract: We describe seven patients with chronic osteomyelitis which developed in 3 following operation and in 4 after trauma. The treatment consisted of removal of dead tissue and filling the resulting cavities with gentamicin-impregnated xenografts. No antibiotics were used postoperatively. Urine gentamicin levels were above 0.5 microgram/ml for 8 days. The patients were followed up for at least 3.5 years and neither clinical nor laboratory signs of infection were detected. These results lead us the conclusion that gentamicin-impregnated xenografts may have a place in the treatment of chronic osteomyelitis.
authors.affiliation: Department of Orthopaedics, Osmangazi University Hospital, Eskisehir, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Seber
authors.forename: I
authors.initials: I
authors.lastname: Günal
authors.forename: E
authors.initials: E
authors.lastname: Göktürk
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use* / Q000652:urine; D002908:Chronic Disease; D016503:Drug Delivery Systems; D005260:Female; D005269:Femur; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use* / Q000652:urine; D006801:Humans; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000188:drug therapy* / Q000209:etiology / Q000382:microbiology; D013977:Tibia; D014183:Transplantation, Heterologous
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins