title: Determination of the inhibitory effect on Toxoplasma growth in the serum of AIDS patients during acute therapy for toxoplasmic encephalitis.
abstract: In 26 AIDS patients treated for toxoplasmic encephalitis, the inhibitory effect on Toxoxplasma growth of sequential sera taken before and after initiation of therapy was determined using a culture-based immunoassay and compared with pyrimethamine blood levels. A marked inhibition of Toxoplasma growth was observed 1 day after initiation of therapy with pyrimethamine plus sulfadiazine and was maintained between 67% and 93% throughout the 15-day follow-up period. The degree of inhibition was not correlated to pyrimethamine blood levels and seemed highly potentiated when sulfadiazine rather than macrolides was given in combination with pyrimethamine.
authors.affiliation: Laboratoire de Parasitologie, Hôpital Saint-Louis, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Derouin
authors.forename: L
authors.initials: L
authors.lastname: Gérard
authors.forename: R
authors.initials: R
authors.lastname: Farinotti
authors.forename: C
authors.initials: C
authors.lastname: Maslo
authors.forename: C
authors.initials: C
authors.lastname: Leport
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000150:complications*; D000328:Adult; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004660:Encephalitis / Q000188:drug therapy* / Q000469:parasitology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D018942:Macrolides; D008297:Male; D011739:Pyrimethamine / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D013411:Sulfadiazine / Q000494:pharmacology / Q000627:therapeutic use*; D014122:Toxoplasma / Q000187:drug effects* / Q000254:growth & development; D016781:Toxoplasmosis, Cerebral / Q000188:drug therapy* / Q000469:parasitology
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D018942:Macrolides; D013411:Sulfadiazine; D011739:Pyrimethamine