title: Advanced paternal age and de-novo complex chromosomal rearrangement in offspring.
abstract: We report one case of a de-novo complex chromosomal rearrangement (CCR), t(1;5;13)ins(14;13), in an abnormal 19-month-old boy. Clinical features associated were a mild facial dysmorphy and a psychomotor retardation. Parental ages were, respectively, 29 years for the mother and 60 years for the father. We point out the usefulness of fluorescence in-situ hybridization in elucidating CCRs, and discuss the possible correlation between the existence of a chromosomal aberration and advanced paternal age.
authors.affiliation: Laboratoire d'Histologie, Embryologie, Cytogénétique et Biologie de la Reproduction, Hôpital Jean Verdier, Bondy, France.
authors.forename: B
authors.initials: B
authors.lastname: Benzacken
authors.forename: J P
authors.initials: JP
authors.lastname: Siffroi
authors.forename: B
authors.initials: B
authors.lastname: Straub
authors.forename: C
authors.initials: C
authors.lastname: Le Bourhis
authors.forename: S
authors.initials: S
authors.lastname: Sauvion
authors.forename: J
authors.initials: J
authors.lastname: Gaudelus
authors.forename: J P
authors.initials: JP
authors.lastname: Dadoune
authors.forename: J P
authors.initials: JP
authors.lastname: Wolf
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1; D002882:Chromosomes, Human, Pair 13; D002883:Chromosomes, Human, Pair 14; D002895:Chromosomes, Human, Pair 5; D005147:Facial Bones / Q000002:abnormalities*; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D010331:Paternal Age; D011596:Psychomotor Disorders / Q000235:genetics*