title: Proton magnetic resonance spectroscopy in primary blepharospasm.
abstract: Single-volume proton magnetic resonance spectroscopy, localized to basal ganglia, was carried out in 10 patients with primary blepharospasm (PB) to assess the levels of N-acetyl aspartate (NAA), creatine-phosphocreatine, and choline-containing compounds. NAA was reduced significantly in patients compared with control subjects. This result suggests a striatal neuronal loss in PB.
authors.affiliation: Department of Neurology and Psychiatry, University of Bari, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Federico
authors.forename: I L
authors.initials: IL
authors.lastname: Simone
authors.forename: V
authors.initials: V
authors.lastname: Lucivero
authors.forename: G
authors.initials: G
authors.lastname: Defazio
authors.forename: R
authors.initials: R
authors.lastname: De Salvia
authors.forename: D M
authors.initials: DM
authors.lastname: Mezzapesa
authors.forename: M
authors.initials: M
authors.lastname: Petruzzellis
authors.forename: C
authors.initials: C
authors.lastname: Tortorella
authors.forename: P
authors.initials: P
authors.lastname: Livrea
mesh_terms: D000368:Aged; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000032:analysis; D001479:Basal Ganglia / Q000737:chemistry*; D001764:Blepharospasm / Q000175:diagnosis*; D002794:Choline / Q000032:analysis; D003401:Creatine / Q000032:analysis; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D010725:Phosphocreatine / Q000032:analysis
chemical_list: D010725:Phosphocreatine; D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline