[Studies for dynamics of reverse transcriptase inhibiting antibody in sera from HIV-1 infected individuals].
Antibodies inhibiting human immunodeficiency virus type 1 (HIV-1) reverse transcriptase activity (RTI-antibody), Binding inhibition antibody (BI-antibody) and polymerization inhibition antibody (PI-antibody) were investigated for their ability to inhibiting RT activity in 248 HIV-1 infected individuals and 99 healthy individuals. In BI-antibody, high titer samples were determined more in than in RTI- and PI-antibodies. No significance was indicated between AC, ARC and AIDS is any antibody, however, progression from AC to AIDS was poled to high titer and low titer in RTI- and BI-antibodies. Moreover, time course of each antibody levels in the same infected individuals were resulted in no change, going up or down through all the experimental term, though all samples were collected in AC. These results were suggested that the determination factor of each stage in HIV progression would be multiple, and that the various dynamics of RTI-, BI- and PI-antibodies in the same infected individuals might be caused in the term from HIV infection to AIDS progression, prognosis or appearing of the drug resistant strain but stages of the disease.
Odawara
F
F
Diagnostic Division, Asahi Chemical Industry, Co., Ltd.
Sano
K
K
Otake
T
T
Okubo
S
S
Nakano
T
T
Takasaki
T
T
Misaki
H
H
Nakai
M
M
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology; D000906:Antibodies / Q000097:blood*; D015658:HIV Infections / Q000276:immunology*; D054303:HIV Reverse Transcriptase / Q000276:immunology*; D015497:HIV-1; D006801:Humans; D018894:Reverse Transcriptase Inhibitors / Q000097:blood*
D000906:Antibodies; D018894:Reverse Transcriptase Inhibitors; D054303:HIV Reverse Transcriptase