Functional activity of immune cells in female MS-patients.
Since the well documented immunological disturbances in patients suffering from multiple sclerosis are especially attributed to T-cells we felt it expedient to look also for the functional activity of lymphocytes, monocytes, granulocytes and natural killer cells in the peripheral blood of female MS-patients (n = 17) and healthy controls (n = 17). While MS-patients showed decreased levels of total lymphocytes, CD2(+)- and CD8(+)-cells the percentage of HLA-DR(+)-monocytes was increased, indicating a high activity level of these immune cells, whereas we could find no differences in the functional tests of monocytes, granulocytes and natural killer cells between MS-patients and healthy controls. The percentage of HLA-DR(+)-T-lymphocytes increased with the duration of the illness and support the stronger consideration of clinical staging.
Peters
C
C
Institute of Rehabilitation and Sport for the Disabled, German Sport University, Cologne, Germany.
Lötzerich
H
H
Raabe-Oekter
A
A
Mucha
C
C
Michna
H
H
D015703:Antigens, CD / Q000097:blood; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D005260:Female; D006098:Granulocytes / Q000502:physiology*; D006684:HLA-DR Antigens / Q000097:blood; D006801:Humans; D016130:Immunophenotyping; D008875:Middle Aged; D009000:Monocytes / Q000502:physiology*; D009103:Multiple Sclerosis / Q000097:blood* / Q000276:immunology*; D010587:Phagocytosis; D012016:Reference Values; D016897:Respiratory Burst; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D015703:Antigens, CD; D006684:HLA-DR Antigens