title: Conformationally constrained 1,3-diamino ketones: a series of potent inhibitors of the cysteine protease cathepsin K.
authors.affiliation: Departments of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, USA.
authors.forename: R W
authors.initials: RW
authors.lastname: Marquis
authors.forename: D S
authors.initials: DS
authors.lastname: Yamashita
authors.forename: Y
authors.initials: Y
authors.lastname: Ru
authors.forename: S M
authors.initials: SM
authors.lastname: LoCastro
authors.forename: H J
authors.initials: HJ
authors.lastname: Oh
authors.forename: K F
authors.initials: KF
authors.lastname: Erhard
authors.forename: R L
authors.initials: RL
authors.lastname: DesJarlais
authors.forename: M S
authors.initials: MS
authors.lastname: Head
authors.forename: W W
authors.initials: WW
authors.lastname: Smith
authors.forename: B
authors.initials: B
authors.lastname: Zhao
authors.forename: C A
authors.initials: CA
authors.lastname: Janson
authors.forename: S S
authors.initials: SS
authors.lastname: Abdel-Meguid
authors.forename: T A
authors.initials: TA
authors.lastname: Tomaszek
authors.forename: M A
authors.initials: MA
authors.lastname: Levy
authors.forename: D F
authors.initials: DF
authors.lastname: Veber
mesh_terms: D001665:Binding Sites; D056657:Cathepsin K; D002403:Cathepsins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D018360:Crystallography, X-Ray; D015853:Cysteine Proteinase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D003959:Diamines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008958:Models, Molecular; D008968:Molecular Conformation; D018716:Molecular Mimicry; D010455:Peptides / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D015853:Cysteine Proteinase Inhibitors; D003959:Diamines; D007659:Ketones; D010455:Peptides; D002403:Cathepsins; D056657:Cathepsin K