[Host reactions affect cancer progression].
The tumor-host relationship is one of the factors determining the biological behavior of malignant tumors. In colon cancer, the costimulatory molecules B7-1/B7-2 are expressed by macrophages distributed along the invasive margin (tumor-host interface). T-lymphocytes are also distributed in the same area with direct cell-to-cell contact with these B7+ macrophages. The distribution of these macrophages is lower in colon cancer patients with liver metastasis. CD8+ T cells are distributed within cancer cell nests of colon cancer. The survival rate of patients with higher levels of these T-cells is favorable. Our data suggest the presence of a host immune reaction by macrophages and T-lymphocytes, which diminishes the aggressiveness of cancer cells. As shown in the present paper, comparative analysis is required to assess the biological behavior of cancer.
Ohtani
H
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Tohoku University School of Medicine, Sendai, Japan.
D017951:Antigen Presentation; D015703:Antigens, CD / Q000378:metabolism; D018122:B7-1 Antigen / Q000378:metabolism; D051940:B7-2 Antigen; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D003110:Colonic Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008264:Macrophages / Q000276:immunology; D008562:Membrane Glycoproteins / Q000378:metabolism; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D011379:Prognosis
D015703:Antigens, CD; D018122:B7-1 Antigen; D051940:B7-2 Antigen; C497964:CD86 protein, human; D008562:Membrane Glycoproteins