Fibroblast growth factor receptor-1 expression in the cortex and hippocampus in Alzheimer's disease.
Localization of fibroblast growth receptor (FGFR)-1 immunoreactivity was investigated immunochemically in postmortem brain tissue of Alzheimer's disease (AD) and age-matched control cases using a rabbit polyclonal antibody and a mouse monoclonal antibody specific for FGFR-1. In control cases, FGFR-1 immunoreactivity was identified in astrocytes in white matter and in hippocampal pyramidal neurons. In AD cases, the immunoreactivity in reactive astrocytes surrounding senile plaques was increased. The pattern of FGFR-1 immunoreactivity was confirmed in selected cases by in situ hybridization for FGFR-1 mRNA. Immunoreactivity using a monoclonal antibody demonstrated a similar distribution pattern. The localization of FGFR-1 is consistent with previous reports on the involvement of FGF-1 and FGF-2 in AD.
Takami
K
K
Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, Canada.
Matsuo
A
A
Terai
K
K
Walker
D G
DG
McGeer
E G
EG
McGeer
P L
PL
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism*; D000818:Animals; D000911:Antibodies, Monoclonal; D001253:Astrocytes / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism* / Q000473:pathology; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D015151:Immunoblotting; D007150:Immunohistochemistry / Q000379:methods; D017403:In Situ Hybridization; D051379:Mice; D017966:Pyramidal Cells / Q000378:metabolism; D011817:Rabbits; D017468:Receptors, Fibroblast Growth Factor / Q000378:metabolism*; D012016:Reference Values
D000911:Antibodies, Monoclonal; D017468:Receptors, Fibroblast Growth Factor