Papillary thyroid carcinoma: justification for total thyroidectomy and management of lymph node metastases.
Papillary thyroid carcinoma (PTC) is the most common epithelial thyroid tumor and comprises approximately 80% of all thyroid cancers. In this article, the authors discuss the data showing that total thyroidectomy is the treatment of choice of clinically significant PTC, and review an algorithm for the management of lymph node metastases. Although the prognosis for patients with PTC is generally good, appropriate surgical management (total thyroidectomy plus 131I and life-long TSH suppression) can further reduce recurrence and cancer death rates significantly.
Chen
H
H
Division of Surgical Oncology, Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Udelsman
R
R
D000465:Algorithms; D002291:Carcinoma, Papillary / Q000556:secondary / Q000601:surgery*; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D011379:Prognosis; D019275:Radiopharmaceuticals / Q000627:therapeutic use; D015996:Survival Rate; D013964:Thyroid Neoplasms / Q000601:surgery*; D013965:Thyroidectomy; D013972:Thyrotropin / Q000037:antagonists & inhibitors
D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D013972:Thyrotropin