Effects of immunomodulators on postirradiation recovery in the thymus.
The effect of immunomodulatory agents on reparation processes in the thymus was studied in mice injured by a single sublethal or lethal dose of ionizing radiation ranging between 6.5-9.5 Gy. Reparation of thymus weight was not influenced by pretreatment with immunomodulators. Furthermore, the morphological picture did not exhibit appreciable differences between non-protected and protected groups, except for greater proliferation of fibroblasts and macrophages in protected animals.
Macková
N O
NO
Department of Cellular and Molecular Biology, Faculty of Sciences, Safárik University, Kosice, Slovak Republic.
Fedorocko
P
P
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives / Q000627:therapeutic use; D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D004999:Amifostine / Q000627:therapeutic use; D000818:Animals; D001284:Atrophy; D001419:Bacteria; D002455:Cell Division; D002457:Cell Extracts; D003037:Cobalt Radioisotopes; D005260:Female; D005347:Fibroblasts / Q000473:pathology; D008206:Lymphatic Diseases / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D008264:Macrophages / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D009929:Organ Size; D010714:Phosphatidylethanolamines / Q000627:therapeutic use; D011832:Radiation Injuries / Q000628:therapy*; D011837:Radiation-Protective Agents / Q000627:therapeutic use; D013950:Thymus Gland / Q000473:pathology / Q000528:radiation effects; D000095983:Bacterial Lysates
D000119:Acetylmuramyl-Alanyl-Isoglutamine; D000276:Adjuvants, Immunologic; D004999:Amifostine; D002457:Cell Extracts; D003037:Cobalt Radioisotopes; D010714:Phosphatidylethanolamines; D011837:Radiation-Protective Agents; C030259:Broncho-Vaxom; D000095983:Bacterial Lysates; C079233:IRS 19; C037144:mifamurtide