Evaluation of a collagen-alginate wound dressing in the management of diabetic foot ulcers.
Efficacy and safety of a collagen-alginate topical wound dressing (FIBRACOL Collagen-Alginate Wound Dressing) in the treatment of diabetic foot ulcers was compared with that of regular gauze moistened with normal saline. Seventy-five patients with foot ulcers were assigned randomly in a 2:1 ratio to the collagen-alginate test dressing or the gauze dressing. At the end of the study, the mean percent reduction of the wound area was 80.6% +/- 6% in the collagen-alginate dressing group and 61.1% +/- 26% in the gauze dressing group (p = .4692). Thirty-nine (78%) patients treated with the collagen-alginate dressing achieved > or = 75% wound area reduction, compared with 15 (60%) of gauze-treated patients. Complete healing was achieved in 24 (48%) of the collagen-alginate dressing group and 9 (36%) of the gauze dressing group. Wound size, when averaged over the 8-week period and with the duration of the ulcer taken into account, was reduced significantly in the collagen-alginate dressing group, as compared with the gauze dressing group (df = 1, p = .0049). It is concluded that the collagen-alginate test dressing is as or more effective and safe as the currently used treatment.
Donaghue
V M
VM
Beth Israel Deaconsess Medical Center, Harvard Medical School, Boston, MA, USA.
Chrzan
J S
JS
Rosenblum
B I
BI
Giurini
J M
JM
Habershaw
G M
GM
Veves
A
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000464:Alginates / Q000627:therapeutic use*; D001458:Bandages / Q000592:standards*; D003094:Collagen / Q000627:therapeutic use*; D017719:Diabetic Foot / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012965:Sodium Chloride / Q000627:therapeutic use; D014945:Wound Healing
D000464:Alginates; D012965:Sodium Chloride; D003094:Collagen