Anti-HIV-1 activity of herbs in Labiatae.
The anti-HIV-1 activity of aromatic herbs in Labiatae was evaluated in vitro. Forty five extract from among 51 samples obtained from 46 herb species showed significant inhibitory effects against HIV-1 induced cytopathogenicity in MT-4 cells. In particular, the aqueous extracts of Melissa officinalis, a family of Mentha x piperita "grapefruit mint," Mentha x piperita var. crispa, Ocimum basilicum cv "cinnamon," Perilla frutescens var. crispa f. viridis, Prunella vulgaris subsp. asiatica and Satureja montana showed potent anti-HIV-1 activity (with an ED of 16 microg/ml). The active components in the extract samples were found to be water-soluble polar substances, not nonpolar compounds such as essential oils. In addition, these aqueous extracts inhibited giant cell formation in co-culture of Molt-4 cells with and without HIV-1 infection and showed inhibitory activity against HIV-1 reverse transcriptase.
Yamasaki
K
K
Osaka Prefectural Institute of Public Health, Japan.
Nakano
M
M
Kawahata
T
T
Mori
H
H
Otake
T
T
Ueba
N
N
Oishi
I
I
Inami
R
R
Yamane
M
M
Nakamura
M
M
Murata
H
H
Nakanishi
T
T
D019380:Anti-HIV Agents / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D019686:Lamiaceae; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology
D019380:Anti-HIV Agents; D010936:Plant Extracts; D018894:Reverse Transcriptase Inhibitors