Azocrosslinked poly(acrylic acid) for colonic delivery and adhesion specificity: in vitro degradation and preliminary ex vivo bioadhesion studies.
This study reports on the performance of a novel polymeric material that is capable of providing site specificity in active agent delivery and the development of mucoadhesive interactions. Azo-networks, based on an acrylic backbone crosslinked with 4,4'-divinylazobenzene, were subjected to in vitro degradation and mucoadhesion (before and after degradation) testing in order to model their performance in the gastrointestinal tract. Advanced surface characterisation techniques (SEM, AFM, FTIR microscopy) were used to examine the network morphology prior to, and after degradation. The data obtained from these studies indicate that there is an optimum crosslinking density to allow non-adhesive particles to reach the colon. Within the colonic environment, the azo network degrades to produce a structure capable of developing mucoadhesive interactions with the colonic mucosa.
Kakoulides
E P
EP
Drug Delivery Research Group, School of Pharmacy and Biomedical Sciences, University of Portsmouth, UK.
Smart
J D
JD
Tsibouklis
J
J
D000180:Acrylic Resins / Q000737:chemistry; D000818:Animals; D001391:Azo Compounds / Q000737:chemistry; D002448:Cell Adhesion; D002474:Cell-Free System; D003106:Colon; D003432:Cross-Linking Reagents / Q000737:chemistry; D004337:Drug Carriers; D007413:Intestinal Mucosa; D008297:Male; D018625:Microscopy, Atomic Force; D051381:Rats; D017208:Rats, Wistar
D000180:Acrylic Resins; D001391:Azo Compounds; D003432:Cross-Linking Reagents; D004337:Drug Carriers