The effect of cisapride on dyspepsia symptoms and the electrogastrogram in patients with non-ulcer dyspepsia.
BACKGROUND
The electrogastrogram (EGG), which records gastric myoelectrical activity, is abnormal in one-third of adult patients with non-ulcer dyspepsia (NUD).


OBJECTIVE
To observe the effects of cisapride on EGG in adults with NUD.


METHODS
Twenty-seven NUD patients who had undergone a pre- and post-prandial EGG were entered into an open study. All patients completed a dyspepsia symptom questionnaire and were then treated with cisapride 10 mg t.d.s. The dyspepsia questionnaire was repeated in all those completing 4 weeks of treatment. Those with an initial abnormal EGG (< 70% of slow wave activity at 2-4 cycles per minute) had a repeat EGG at the end of the study.


RESULTS
Treatment with cisapride was associated with a significant improvement in the post-prandial EGG (P = 0.007). After 4 weeks of treatment, 7 of 13 abnormal EGGs normalized. Symptom scores improved significantly in the 13 patients with an abnormal EGG who completed treatment (P < 0.0003), but not in NUD patients with a normal EGG (P = 0.48).


CONCLUSIONS
In this open study, treatment of NUD with cisapride was associated with significant symptom improvement in patients with an abnormal pre-treatment EGG, but not those with a normal EGG, with a significant improvement of the post-prandial EGG.
Besherdas
K
K
Centre for Gastroenterology, Department of Medicine, Royal Free Hospital School of Medicine, London, UK.
Leahy
A
A
Mason
I
I
Harbord
M
M
Epstein
O
O
D000328:Adult; D020117:Cisapride / Q000494:pharmacology*; D004415:Dyspepsia / Q000188:drug therapy* / Q000503:physiopathology; D004576:Electromyography; D005746:Gastric Emptying / Q000502:physiology*; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D006801:Humans; D019518:Postprandial Period; D013270:Stomach / Q000187:drug effects / Q000503:physiopathology*; D016896:Treatment Outcome
D005765:Gastrointestinal Agents; D020117:Cisapride