PAGE-1, an X chromosome-linked GAGE-like gene that is expressed in normal and neoplastic prostate, testis, and uterus.
We have used a combination of computerized database mining and experimental expression analyses to identify a gene that is preferentially expressed in normal male and female reproductive tissues, prostate, testis, fallopian tube, uterus, and placenta, as well as in prostate cancer, testicular cancer, and uterine cancer. This gene is located on the human X chromosome, and it is homologous to a family of genes encoding GAGE-like proteins. GAGE proteins are expressed in a variety of tumors and in testis. We designate the novel gene PAGE-1 because the expression pattern in the Cancer Genome Anatomy Project libraries indicates that it is predominantly expressed in normal and neoplastic prostate. Further database analysis indicates the presence of other genes with high homology to PAGE-1, which were found in cDNA libraries derived from testis, pooled libraries (with testis), and in a germ cell tumor library. The expression of PAGE-1 in normal and malignant prostate, testicular, and uterine tissues makes it a possible target for the diagnosis and possibly for the vaccine-based therapy of neoplasms of prostate, testis, and uterus.
Brinkmann
U
U
Laboratory of Molecular Biology, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Building 37, Room 4E16, 37 Convent Drive MSC 4255, Bethesda, MD 20892-4255, USA.
Vasmatzis
G
G
Lee
B
B
Yerushalmi
N
N
Essand
M
M
Pastan
I
I
D000595:Amino Acid Sequence; D000951:Antigens, Neoplasm / Q000235:genetics*; D018076:DNA, Complementary; D016208:Databases, Factual; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D011467:Prostate / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D013736:Testicular Neoplasms / Q000235:genetics; D013737:Testis / Q000378:metabolism; D014594:Uterine Neoplasms / Q000235:genetics; D014599:Uterus / Q000378:metabolism; D014960:X Chromosome
D000951:Antigens, Neoplasm; D018076:DNA, Complementary; C113433:PAGE1 protein, human