Association between tumor angiogenesis and Borrmann type 4 carcinomas of the stomach.
A total of 202 gastric carcinomas, including 33 type 4 carcinomas, were studied. Intratumoral vessels were stained with an anti-CD34 monoclonal antibody before being quantitated by light microscopy (x200). The mean vessel counts for type 4 carcinomas were significantly higher than those for any other type of carcinoma, with the exception of type 1 carcinomas. Multivariate logistic regression showed that the vessel count was one of independent variables associated with type 4 carcinomas. In addition, survival analysis demonstrated that patients with type 4 carcinoma had significantly less favorable survival rates than those with other types of carcinomas.
Tanigawa
N
N
Second Department of Surgery, Fukui Medical School, Fukui, Japan. nobu@fmsrsa.fukui-med.ac.jp
Amaya
H
H
Matsumura
M
M
Lu
C
C
Iki
M
M
D000368:Aged; D002277:Carcinoma / Q000098:blood supply* / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic; D013274:Stomach Neoplasms / Q000098:blood supply* / Q000473:pathology*; D016019:Survival Analysis