title: Disposition of mirosamicin in honeybee hives.
abstract: Disposition of mirosamicin, a macrolide antibiotic, to honeybee adults, larvae, honey and royal jelly in the beehive after in-feed administration to adult bees was studied. Treatment was initiated at the end of July when the availability of natural pollen and nectar was poor. The drug was mixed with pollen-substitute paste and administered to honeybee colonies continuously for a week at a dosage of 200 mg/hive/week. High distributions in adult bees, jelly, larvae and a relatively low distribution in honey, of mirosamicin were observed. One day dosing of microsamin in sucrose syrup, a nectar substitute, resulted in a very high and long lasting residue in honey. Both royal and worker jelly, secreted from the jelly glands of adult bees, are acidic, so that a high distribution of a basic drug, such as mirosamicin, in jelly can be expected. This mechanism was considered to be responsible for a high concentration of mirosamicin in honeybee larvae, the host of Paenibacillus-larvae infection (American foulbrood), as primary larval food is jelly.
authors.affiliation: Research Institute for Animal Science in Biochemistry and Toxicology, Sagamihara, Kanagawa, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Nakajima
authors.forename: T
authors.initials: T
authors.lastname: Sakogawa
authors.forename: A
authors.initials: A
authors.lastname: Okayama
authors.forename: A
authors.initials: A
authors.lastname: Nakamura
authors.forename: T
authors.initials: T
authors.lastname: Hayama
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000032:analysis* / Q000493:pharmacokinetics; D001516:Bees / Q000378:metabolism*; D004355:Drug Stability; D005227:Fatty Acids / Q000032:analysis*; D006722:Honey / Q000032:analysis*; D007301:Insect Hormones / Q000032:analysis; D007814:Larva / Q000378:metabolism; D018942:Macrolides; D000099219:Royal Jelly
chemical_list: D000900:Anti-Bacterial Agents; D005227:Fatty Acids; D007301:Insect Hormones; D018942:Macrolides; D000099219:Royal Jelly; C063027:mirosamicin