title: Dose-dependent hypocholesterolaemic effect of oyster mushroom (Pleurotus ostreatus) in rats.
abstract: A highly significant negative correlation (r=-0.981, p < 0.001) between the amount of oyster mushroom (Pleurotus ostreatus) in the diet and cholesterol levels in the serum has been found in male Wistar rats fed shortly after weaning by a a diet with 0.3% cholesterol. The addition of 1.0, 2.5 and 5.0% of oyster mushroom to the diet reduced the levels of serum cholesterol by 11, 31 and 46%, respectively. The diet containing 5% of oyster mushroom suppressed cholesterol accumulation in the liver and increased the fraction of cholesterol carried by high-density lipoproteins.
authors.affiliation: Research Institute of Nutrition, Bratislava, Slovak Republic.
authors.forename: P
authors.initials: P
authors.lastname: Bobek
authors.forename: L
authors.initials: L
authors.lastname: Ozdín
authors.forename: I
authors.initials: I
authors.lastname: Kajaba
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D004032:Diet; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000378:metabolism; D008297:Male; D020076:Pleurotus / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
chemical_list: D000924:Anticholesteremic Agents; D008055:Lipids; D008074:Lipoproteins