Population pharmacokinetic analysis of mexiletine in adult arrhythmic patients in Japanese population.
We analyzed mexiletine in Japanese patients using population pharmacokinetics. 139 serum concentration data, which were collected for therapeutic drug monitoring from 121 patients, were used for this analysis. We also investigated influence of age and gender on pharmacokinetics, and age was found to be an influential factor on clearance. The final pharmacokinetic parameters are, CL/F=0.580-0.00369 x AGE (l/h/kg) and Vd/F=6.63 (l/kg). These results should be useful for adjusting the dosage to a patient's age for the prevention of an adverse reaction caused by overexposure.
Uenaka
K
K
Otsuka Assay Laboratory, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan.
Koue
T
T
Iwai
T
T
Shibakawa
M
M
Ueno
K
K
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000889:Anti-Arrhythmia Agents / Q000493:pharmacokinetics*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008801:Mexiletine / Q000493:pharmacokinetics*; D008875:Middle Aged
D000889:Anti-Arrhythmia Agents; D008801:Mexiletine