APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth.
Members of the tumor necrosis factor (TNF) family induce pleiotropic biological responses, including cell growth, differentiation, and even death. Here we describe a novel member of the TNF family designated APRIL (for a proliferation-inducing ligand). Although transcripts of APRIL are of low abundance in normal tissues, high levels of mRNA are detected in transformed cell lines, and in human cancers of colon, thyroid, and lymphoid tissues in vivo. The addition of recombinant APRIL to various tumor cells stimulates their proliferation. Moreover, APRIL-transfected NIH-3T3 cells show an increased rate of tumor growth in nude mice compared with the parental cell line. These findings suggest that APRIL may be implicated in the regulation of tumor cell growth.
Hahne
M
M
Institute of Biochemistry, Lausanne Branch, University of Lausanne, Epalinges, Switzerland.
Kataoka
T
T
Schröter
M
M
Hofmann
K
K
Irmler
M
M
Bodmer
J L
JL
Schneider
P
P
Bornand
T
T
Holler
N
N
French
L E
LE
Sordat
B
B
Rimoldi
D
D
Tschopp
J
J
D016475:3T3 Cells; D000595:Amino Acid Sequence; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D008024:Ligands; D016393:Lymphoma, B-Cell; D008565:Membrane Proteins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008969:Molecular Sequence Data; D009368:Neoplasm Transplantation; D012333:RNA, Messenger / Q000096:biosynthesis; D014162:Transfection; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D053300:Tumor Necrosis Factor Ligand Superfamily Member 13; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology*
D006133:Growth Substances; D008024:Ligands; D008565:Membrane Proteins; D012333:RNA, Messenger; C114631:TNFSF13 protein, human; C491959:Tnfsf13 protein, mouse; D053300:Tumor Necrosis Factor Ligand Superfamily Member 13; D014409:Tumor Necrosis Factor-alpha