Reverse mutations--spontaneous amelioration or cure of inherited disorders?
Some recent publications indicate that inherited disorders can ameliorate or possibly disappear if mutations responsible for the disease revert to normal. This review tries to summarize our current knowledge about reverse mutations as this information may be of special interest for attempts at somatic gene therapy.
Wahn
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Universität-Kinderklinik, Düsseldorf, Germany.
Stephan
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Hirschhorn
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D002648:Child; D004252:DNA Mutational Analysis; D005785:Gene Conversion; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D018095:Germ-Line Mutation; D006801:Humans; D009030:Mosaicism; D011995:Recombination, Genetic