title: [The factors of hereditary predisposition to lymphogranulomatosis].
abstract: OBJECTIVE
  To determine genetic factors of predisposition marked HLA with reference to serological and molecular characteristics.
  
  
  METHODS
  Four groups of patients were included in the study: 51 patients with lymphogranulomatosis (LGM), 33 healthy relatives of these patients, 37 patients with chronic myeloid leukemia (CML), 24 healthy relatives of these CML patients. 224 donors served control. HLA-antigens were identified with the lymphocytoxic test and PSR-MSSR. Results of typing of class II antigens were taken into consideration in coincidence of serological and DNA typing. The significance of the differences was estimated according to the chi-square criterion.
  
  
  RESULTS
  Differences in frequency of distribution of HLA-antigens (subloci A and B) were not found. Antigen CW7 was present in 70, DR5 in 60, DR6 in 50% of LGM patients. This frequency was much higher than in control groups. Carriers of CW7 are at 7 times higher risk to develop LGM. Among LGM patients the number of homozygous individuals is higher than in healthy ones (50 and 15.6%) while the number of individuals with a complete set of HLA-A.B antigens is significantly less.
  
  
  CONCLUSIONS
  Genetic predisposition to LGM is predetermined by HLA antigens CW7, DR5, DR6. Genes HLA-DR1 and HLA-DR7 protect carriers from factors provoking LGM. Common HLA genes in the parents predispose their children to LGM. Insufficiency of the phenotype is a factor predisposing to LGM.
authors.forename: Iu M
authors.initials: IuM
authors.lastname: Zaretskaia
authors.forename: A V
authors.initials: AV
authors.lastname: Pivnik
authors.forename: E G
authors.initials: EG
authors.lastname: Klinova
authors.forename: N A
authors.initials: NA
authors.lastname: Rasstrigin
authors.forename: E G
authors.initials: EG
authors.lastname: Khamaganova
authors.forename: S M
authors.initials: SM
authors.lastname: Aleshchenko
authors.forename: O V
authors.initials: OV
authors.lastname: Margolin
mesh_terms: D016009:Chi-Square Distribution; D004198:Disease Susceptibility; D005819:Genetic Markers / Q000235:genetics; D006680:HLA Antigens / Q000097:blood / Q000235:genetics; D006689:Hodgkin Disease / Q000235:genetics* / Q000276:immunology; D006720:Homozygote; D006801:Humans; D007125:Immunogenetics; D010641:Phenotype; D012307:Risk Factors
chemical_list: D005819:Genetic Markers; D006680:HLA Antigens