title: Feature space analysis of MRI.
abstract: This paper presents an MRI feature-space image-analysis method and its application to brain tumor studies. The proposed method generates a transformed feature space in which the normal tissues (white matter, gray matter, and CSF) become orthonormal. As such, the method is expected to have site-to-site and patient-to-patient consistency, and is useful for identification of tissue types, segmentation of tissues, and quantitative measurements on tissues. The steps of the work accomplished are as follows: (1) Four T2-weighted and two T1-weighted images (before and after injection of gadolinium) were acquired for 10 tumor patients. (2) Images were analyzed by an image analyst according to the proposed algorithm. (3) Biopsy samples were extracted from each patient and were subsequently analyzed by the pathology laboratory. (4) Image-analysis results were compared with the biopsy results. Pre- and postsurgery feature spaces were also compared. The proposed method made it possible to visualize the MRI feature space and to segment the image. In all cases, the operators were able to find clusters for normal and abnormal tissues. Also, clusters for different zones of the tumor were found. The method successfully segmented the image into normal tissues (white matter, gray matter, and CSF) and different zones of the lesion (tumor, cyst, edema, radiation necrosis, necrotic core, and infiltrated tumor). The results agreed with those obtained from the biopsy samples. Comparison of pre- with postsurgery and radiation feature spaces illustrated that the original solid tumor was not present in the second study, but a new tissue component appeared in a different location of the feature space. This tissue could be radiation necrosis generated as a result of radiation.
authors.affiliation: Department of Diagnostic Radiology, Henry Ford Health System, Detroit, Michigan, USA.
authors.forename: H
authors.initials: H
authors.lastname: Soltanian-Zadeh
authors.forename: J P
authors.initials: JP
authors.lastname: Windham
authors.forename: D J
authors.initials: DJ
authors.lastname: Peck
authors.forename: T
authors.initials: T
authors.lastname: Mikkelsen
mesh_terms: D016477:Artifacts; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000628:therapy; D003131:Combined Modality Therapy; D003199:Computer Systems; D017352:Echo-Planar Imaging / Q000295:instrumentation; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D009336:Necrosis; D012680:Sensitivity and Specificity; D012984:Software; D016896:Treatment Outcome