Activity of liposomal amphotericin B with prolonged circulation in blood versus those of AmBisome and fungizone against intracellular Candida albicans in murine peritoneal macrophages.
Activity against intracellular Candida albicans was assessed in C. albicans-infected murine peritoneal macrophages exposed to long-circulating pegylated amphotericin B liposomes (PEG-AMB-LIP), AmBisome, or Fungizone. The level of antifungal activity of Fungizone is much higher than that of AmBisome or PEG-AMB-LIP, while PEG-AMB-LIP and AmBisome show equivalent activity levels. Previous exposure of uninfected macrophages to PEG-AMB-LIP or AmBisome is advantageous for intracellular antifungal activity.
van Etten
E W
EW
Department of Medical Microbiology and Infectious Diseases, Erasmus University Rotterdam, Rotterdam, The Netherlands. vanetten@kmic.fgg.eur.nl
van Vianen
W
W
Hak
J
J
Bakker-Woudenberg
I A
IA
D000666:Amphotericin B / Q000008:administration & dosage* / Q000097:blood; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage*; D002176:Candida albicans / Q000187:drug effects*; D004337:Drug Carriers; D005260:Female; D008081:Liposomes; D017737:Macrophages, Peritoneal / Q000382:microbiology*; D051379:Mice; D008807:Mice, Inbred BALB C
D000935:Antifungal Agents; D004337:Drug Carriers; D008081:Liposomes; D000666:Amphotericin B