title: (Z,Z)-2,7-Bis(4-amidinobenzylidene)cycloheptan-1-one: identification of a highly active inhibitor of blood coagulation factor Xa.
authors.affiliation: Discovery Research, Berlex Biosciences, 15049 San Pablo Avenue, P.O. Box 4099, Richmond, California 94804-0099, USA.
authors.forename: K J
authors.initials: KJ
authors.lastname: Shaw
authors.forename: W J
authors.initials: WJ
authors.lastname: Guilford
authors.forename: J L
authors.initials: JL
authors.lastname: Dallas
authors.forename: S K
authors.initials: SK
authors.lastname: Koovakkaat
authors.forename: M A
authors.initials: MA
authors.lastname: McCarrick
authors.forename: A
authors.initials: A
authors.lastname: Liang
authors.forename: D R
authors.initials: DR
authors.lastname: Light
authors.forename: M M
authors.initials: MM
authors.lastname: Morrissey
mesh_terms: D000578:Amidines / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology / Q000528:radiation effects; D000818:Animals; D001597:Benzylidene Compounds / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology / Q000528:radiation effects; D001665:Binding Sites; D002417:Cattle; D065427:Factor Xa Inhibitors; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation / Q000528:radiation effects; D010777:Photochemistry; D015842:Serine Proteinase Inhibitors / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology / Q000528:radiation effects; D013237:Stereoisomerism; D013917:Thrombin / Q000037:antagonists & inhibitors; D014361:Trypsin Inhibitors / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology / Q000528:radiation effects
chemical_list: D000578:Amidines; D001597:Benzylidene Compounds; D065427:Factor Xa Inhibitors; D015842:Serine Proteinase Inhibitors; D014361:Trypsin Inhibitors; C114591:ZK 805412; D013917:Thrombin