title: Conversion of neuronal growth cone responses from repulsion to attraction by cyclic nucleotides.
abstract: Nerve growth is regulated by attractive and repulsive factors in the nervous system. Microscopic gradients of Collapsin-1/Semaphorin III/D (Sema III) and myelin-associated glycoprotein trigger repulsive turning responses by growth cones of cultured Xenopus spinal neurons; the repulsion can be converted to attraction by pharmacological activation of the guanosine 3',5'-monophosphate (cGMP) and adenosine 3',5'-monophosphate signaling pathways, respectively. Sema III also causes the collapse of cultured rat sensory growth cones, which can be inhibited by activation of the cGMP pathway. Thus cyclic nucleotides can regulate growth cone behaviors and may be targets for designing treatments to alleviate the inhibition of nerve regeneration by repulsive factors.
authors.affiliation: Department of Biology, University of California at San Diego, La Jolla, CA 92093-0357, USA.
authors.forename: H
authors.initials: H
authors.lastname: Song
authors.forename: G
authors.initials: G
authors.lastname: Ming
authors.forename: Z
authors.initials: Z
authors.lastname: He
authors.forename: M
authors.initials: M
authors.lastname: Lehmann
authors.forename: L
authors.initials: L
authors.lastname: McKerracher
authors.forename: M
authors.initials: M
authors.lastname: Tessier-Lavigne
authors.forename: M
authors.initials: M
authors.lastname: Poo
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology; D002118:Calcium / Q000502:physiology; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000031:analogs & derivatives / Q000494:pharmacology / Q000502:physiology*; D006152:Cyclic GMP / Q000031:analogs & derivatives / Q000494:pharmacology / Q000502:physiology*; D005727:Ganglia, Spinal / Q000166:cytology; D006023:Glycoproteins / Q000502:physiology*; D018992:Myelin-Associated Glycoprotein / Q000502:physiology; D009414:Nerve Growth Factors / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000502:physiology; D016501:Neurites / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D039942:Neuropilin-1; D051381:Rats; D011994:Recombinant Proteins; D040121:Semaphorin-3A; D013116:Spinal Cord / Q000166:cytology; D013873:Thionucleotides / Q000494:pharmacology; D014981:Xenopus
chemical_list: D006023:Glycoproteins; D018992:Myelin-Associated Glycoprotein; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D011994:Recombinant Proteins; D040121:Semaphorin-3A; D013873:Thionucleotides; D039942:Neuropilin-1; C016957:adenosine-3',5'-cyclic phosphorothioate; C016276:8-bromocyclic GMP; D000242:Cyclic AMP; D006152:Cyclic GMP; D002118:Calcium