title: The new gene DmX from Drosophila melanogaster encodes a novel WD-repeat protein.
abstract: DmX is a novel gene from Drosophila melanogaster located on the X chromosome in region 5D5/6-E1. The molecular analysis of the genomic and cDNA sequences of DmX shows that the gene spans appr. 16kb and displays a mosaic structure with 15 exons. The 12kb long DmX transcript is present in Drosophila embryos, larvae and adults of both sexes. The open reading frame of DmX encodes a novel WD-repeat protein, containing at least 30 WD-repeat units. WD-repeat proteins contain a conserved motif of approximately 40 amino acids (aa), usually ending with the dipeptide Trp-Asp (WD). Homologues of the DmX gene exist in other dipteran species, in Caenorhabditis elegans and human, revealing that DmX is an evolutionarily well conserved gene. The inferred DMX amino acid sequence shows also limited, but significant similarity to a yeast ORF with unknown function. 1998 Elsevier Science B.V.
authors.affiliation: Institute for Molecular Genetics, Biosafety Research and Consulting, Johannes Gutenberg-University Mainz, D-55099, Mainz, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Kraemer
authors.forename: B
authors.initials: B
authors.lastname: Weil
authors.forename: M
authors.initials: M
authors.lastname: Christmann
authors.forename: E R
authors.initials: ER
authors.lastname: Schmidt
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001224:Aspartic Acid / Q000235:genetics; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D017124:Conserved Sequence / Q000235:genetics; D018076:DNA, Complementary / Q000235:genetics; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics*; D005260:Female; D018507:Gene Expression Regulation, Developmental; D017344:Genes, Insect / Q000235:genetics*; D019476:Insect Proteins / Q000235:genetics*; D008297:Male; D008969:Molecular Sequence Data; D016366:Open Reading Frames / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics*; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D014158:Transcription, Genetic; D014364:Tryptophan / Q000235:genetics; D014960:X Chromosome / Q000235:genetics
chemical_list: D018076:DNA, Complementary; C114754:DmX protein, Drosophila; D029721:Drosophila Proteins; D019476:Insect Proteins; D012333:RNA, Messenger; D001224:Aspartic Acid; D014364:Tryptophan