title: A comparison of frozen and paraffin sections in dermatofibrosarcoma protuberans.
abstract: BACKGROUND
  Dermatofibrosarcoma protuberans (DFSP) is a tumor with a high local reoccurrence rate. Mohs micrographic surgery offers the highest cure rate. However, differentiating minimal residual tumor from normal skin can be difficult during Mohs surgery.
  
  
  OBJECTIVE
  To clarify the problem of determining when a tumor-free plane had been achieved during Mohs surgery for a DFSP.
  
  
  METHODS
  In two patients with DFSPs, we compared frozen and paraffin-embedded sections extending from tumor to normal skin, using both H&E and CD34 stains.
  
  
  RESULTS
  On frozen, but not paraffin-embedded, sections scattered dermal spindle cells were seen in normal skin.
  
  
  CONCLUSIONS
  Scattered dermal spindle cells in the dermis of normal skin make it difficult to differentiate minimal residual tumor from normal dermis during Mohs surgery. A biopsy of normal skin can be useful as a control in this setting.
authors.affiliation: Department of Dermatology, Columbia University-College of Physicians and Surgeons, New York, New York, USA.
authors.forename: R A
authors.initials: RA
authors.lastname: Massey
authors.forename: J
authors.initials: J
authors.lastname: Tok
authors.forename: B A
authors.initials: BA
authors.lastname: Strippoli
authors.forename: M J
authors.initials: MJ
authors.lastname: Szabolcs
authors.forename: D N
authors.initials: DN
authors.lastname: Silvers
authors.forename: Y D
authors.initials: YD
authors.lastname: Eliezri
mesh_terms: D001706:Biopsy; D018223:Dermatofibrosarcoma / Q000473:pathology* / Q000601:surgery*; D005629:Frozen Sections / Q000379:methods; D006801:Humans; D015580:Mohs Surgery / Q000379:methods; D016612:Paraffin Embedding / Q000379:methods; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery*; D013048:Specimen Handling