title: Discovery of potent, achiral matrix metalloproteinase inhibitors.
authors.affiliation: Procter and Gamble Pharmaceuticals, Health Care Research Center, 8700 Mason-Montgomery Road, Mason, Ohio 45040, USA.
authors.forename: S
authors.initials: S
authors.lastname: Pikul
authors.forename: K L
authors.initials: KL
authors.lastname: McDow Dunham
authors.forename: N G
authors.initials: NG
authors.lastname: Almstead
authors.forename: B
authors.initials: B
authors.lastname: De
authors.forename: M G
authors.initials: MG
authors.lastname: Natchus
authors.forename: M V
authors.initials: MV
authors.lastname: Anastasio
authors.forename: S J
authors.initials: SJ
authors.lastname: McPhail
authors.forename: C E
authors.initials: CE
authors.lastname: Snider
authors.forename: Y O
authors.initials: YO
authors.lastname: Taiwo
authors.forename: T
authors.initials: T
authors.lastname: Rydel
authors.forename: C M
authors.initials: CM
authors.lastname: Dunaway
authors.forename: F
authors.initials: F
authors.lastname: Gu
authors.forename: G E
authors.initials: GE
authors.lastname: Mieling
mesh_terms: D018360:Crystallography, X-Ray; D020781:Matrix Metalloproteinase 1; D019278:Matrix Metalloproteinase 3 / Q000378:metabolism; D020783:Matrix Metalloproteinase 7; D020780:Matrix Metalloproteinase 9; D061965:Matrix Metalloproteinase Inhibitors; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008958:Models, Molecular; D008968:Molecular Conformation; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D011480:Protease Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D011485:Protein Binding; D013329:Structure-Activity Relationship
chemical_list: D061965:Matrix Metalloproteinase Inhibitors; D010879:Piperazines; D011480:Protease Inhibitors; D008666:Metalloendopeptidases; D019278:Matrix Metalloproteinase 3; D020783:Matrix Metalloproteinase 7; D020780:Matrix Metalloproteinase 9; D020781:Matrix Metalloproteinase 1