Antioxidative defense in human myocardial reperfusion injury.
The activity of glutathione peroxidase (GSH-Px) as well as the activities of other antioxidative enzymes such as CuZn superoxide dismutase (CuZn SOD), catalase (CAT), glutathione reductase (GR) in erythrocytes, the plasma activity of glutathione-S-transferase (GST), and the plasma levels of vitamin E and vitamin C were evaluated in nine patients with acute myocardial infarction (AMI). Blood samples were taken before and 1, 3, 6, and 24 hours after the institution of thrombolytic therapy. The results were compared with those in 30 healthy volunteers. A significant decrease in catalase (CAT) activity and vitamin E content in patients before and after thrombolytic therapy as compared with controls was recorded. Our results confirmed that a disturbed oxidative/antioxidative balance is present after AMI and after thrombolytic therapy.
Dusinović
S
S
Urgent Medical Aid, Belgrade, Yugoslavia.
Mijalković
D
D
Saicić
Z S
ZS
Durić
J
J
Zunić
Z
Z
Niketić
V
V
Spasić
M B
MB
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000627:therapeutic use; D001205:Ascorbic Acid / Q000097:blood; D002374:Catalase / Q000097:blood*; D004912:Erythrocytes / Q000201:enzymology; D005979:Glutathione Peroxidase / Q000097:blood*; D005980:Glutathione Reductase / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy; D015428:Myocardial Reperfusion Injury / Q000097:blood / Q000201:enzymology*; D013482:Superoxide Dismutase / Q000097:blood*; D015912:Thrombolytic Therapy; D014810:Vitamin E / Q000097:blood
D000975:Antioxidants; D014810:Vitamin E; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D001205:Ascorbic Acid