[Pyrimidine derivatives increase antibiotic therapy efficacy after ionizing irradiation].
Pyrimidine derivatives increased the antibiotic therapy efficacy in albino rats irradiated with RUM-7 apparatus for close-focus roentgenotherapy. 2-Methyl-4-amino-6-oxypyrimidine was twice as efficient as oxymethyluracil and 6 times as efficient as methyluracil in the stimulation of the skin reparative regeneration. When the total irradiation was performed with LUCH-1 apparatus in a dose of 6 Gy the pyrimidine derivatives also increased the antibiotic therapy efficacy. After the prophylactic use of the pyrimidine derivatives for 7 days prior to the total irradiation their therapeutic effect increased, the level of the exudative component lowered, the tissue epithelization increased, the terms of the wound healing decreased and the animal lifespan increased.
Ismagilova
A F
AF
Institute of Organic Chemistry, Ufa Scientific Centre, Russian Academy of Sciences, Bashkir State Medical University.
Zarudiĭ
F S
FS
Lazareva
D N
DN
Savitskiĭ
F P
FP
Ismagilova
Z F
ZF
Tropynina
Iu G
IuG
Davydova
V A
VA
Sapozhnikova
T A
TA
D000287:Administration, Topical; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001772:Blood Cell Count; D002056:Burns / Q000097:blood / Q000150:complications / Q000188:drug therapy; D002701:Chloramphenicol / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D011743:Pyrimidines / Q000494:pharmacology* / Q000627:therapeutic use; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D011837:Radiation-Protective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D012867:Skin / Q000187:drug effects* / Q000528:radiation effects; D014498:Uracil / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D014916:Whole-Body Irradiation; D014945:Wound Healing / Q000187:drug effects* / Q000528:radiation effects
C113629:2-methyl-4-amino-6-oxypyrimidine; D000900:Anti-Bacterial Agents; D011743:Pyrimidines; D011837:Radiation-Protective Agents; D014498:Uracil; C008378:6-methyluracil; D002701:Chloramphenicol; C003029:oxymethacil