title: [Leptospirosis in the Netherlands, 1991-1995].
abstract: OBJECTIVE
  To determine all cases of leptospirosis in the Netherlands in 1991-1995 that were confirmed by serological investigation or culturing.
  
  
  METHODS
  Descriptive, retrospective.
  
  
  METHODS
  Department of Biomedical Research, Royal Tropical Institute, Amsterdam, the Netherlands, and Department of Internal Medicine, Academic Medical Centre, Amsterdam, the Netherlands.
  
  
  METHODS
  Using data of the Reference Laboratory for Leptospirosis, the number of leptospirosis cases in 1991-1995 was determined and compared with the data of 1986-1990. Additional information was obtained about patients with confirmed leptospirosis or who had been hospitalized because of leptospirosis.
  
  
  RESULTS
  The number of confirmed cases dropped from 229 in 1986-1990 to 159 in 1991-1995. This decrease could be attributed mainly to a marked decrease of the number of dairy farm fever (hardjo) cases. There was a clear increase of the number of infections acquired during travel in foreign countries, notably outside Europe. Thus, leptospirosis in the Netherlands shifted from an occupational disease towards a disease due to recreational activities. In about 10% of the patients the disease ran a severe course with Weil's syndrome (icterus, renal failure, and haemorrhages). Eight patients (5%) died. Clinical data of 5 of these 8 patients indicated that they had suffered from Weil's syndrome.
authors.affiliation: Academisch Medisch Centrum, afd. Inwendige Geneeskunde, onder-afd. Infectieziekten, Tropische Geneeskunde en Aids, Amsterdam.
authors.forename: D P
authors.initials: DP
authors.lastname: Olszyna
authors.forename: R
authors.initials: R
authors.lastname: Jaspars
authors.forename: P
authors.initials: P
authors.lastname: Speelman
authors.forename: E
authors.initials: E
authors.lastname: van Elzakker
authors.forename: H
authors.initials: H
authors.lastname: Korver
authors.forename: R A
authors.initials: RA
authors.lastname: Hartskeerl
mesh_terms: D003710:Demography; D006801:Humans; D007922:Leptospirosis / Q000175:diagnosis / Q000453:epidemiology*; D009426:Netherlands / Q000453:epidemiology; D009784:Occupational Diseases / Q000453:epidemiology; D015995:Prevalence; D012189:Retrospective Studies; D012698:Serologic Tests; D012959:Socioeconomic Factors; D015996:Survival Rate; D014195:Travel