title: Zenker's diverticulum in the elderly: a neurologic etiology?
abstract: Though described in 1769, the etiology of Zenker's diverticulum remains unclear. Various primary esophageal motor disorders have been proposed, but no consistent manometric pattern or anatomic etiology has been uniformly recognized. An association with clinical neurologic disease at our institution prompted a review of 12 cases of Zenker's diverticulum in patients over 60 years of age, treated in the last 8 years. Nine patients (75%) underwent cricopharyngeus myotomy and diverticulectomy, with uniformly good results. Ten patients (83%) had an associated neurologic disorder, substantiated by cranial CT or MRI, in most cases. A wide range of neurologic problems were identified, but a strong trend toward brainstem or basilar lesions was present. As expected, the etiology of the neurologic abnormality in most patients in this group was cerebrovascular disease, but two patients had peripheral neuropathies. We suggest that the etiology of Zenker's diverticulum in the elderly may be neurologic in origin. Esophageal motor disorders, including incomplete upper esophageal sphincter opening and increased hypopharyngeal pressures, which may result in Zenker's diverticulum, may be a manifestation of central or peripheral neurologic disease in the elderly.
authors.affiliation: Department of Surgery, James H. Quillen College of Medicine, East Tennessee State University, Johnson City 37614, USA.
authors.forename: D N
authors.initials: DN
authors.lastname: Walters
authors.forename: J W
authors.initials: JW
authors.lastname: Battle
authors.forename: C A
authors.initials: CA
authors.lastname: Portera
authors.forename: J D
authors.initials: JD
authors.lastname: Blizzard
authors.forename: I W
authors.initials: IW
authors.lastname: Browder
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001488:Basilar Artery / Q000473:pathology; D001933:Brain Stem / Q000098:blood supply; D002544:Cerebral Infarction / Q000150:complications; D002561:Cerebrovascular Disorders / Q000150:complications* / Q000175:diagnosis; D015154:Esophageal Motility Disorders / Q000150:complications; D004947:Esophagus / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008365:Manometry; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000150:complications; D010609:Pharyngeal Muscles / Q000601:surgery; D011312:Pressure; D014057:Tomography, X-Ray Computed; D016672:Zenker Diverticulum / Q000209:etiology* / Q000473:pathology / Q000601:surgery