title: Technetium-99m labelling of human immunoglobulin and preliminary clinical evaluation in tumour patients.
abstract: In the present investigation we have human immunoglobulin labelled with 99Tc(m), applying two different systems. The radiochemical characteristics of the labelled antibody were studied by conventional, radioanalytical methods. Further on, pharmacokinetics of this 99Tc(m)-labelled biomolecule were investigated, by i.v. administration in women, checked for tumours of the ovaries, uterus and cervix. Scintigraphic findings were compared to the results of other imaging techniques (CT, US, X rays), as well as to surgical findings. Our studies indicated that 99Tc(m)-human immunoglobuline can be applied successfully for the scintigraphic detection of several malignant and benign tumours of the female genital system. Tumour accumulation is probably due to the activation of particular cells, as macrophages and lymphocytes, responsible for inflammatory and immunological responses.
authors.affiliation: National Center of Scientific Research Demokritos Aghia Paraskevi, Athens, Greece.
authors.forename: A D
authors.initials: AD
authors.lastname: Varvarigou
authors.forename: S C
authors.initials: SC
authors.lastname: Archimandritis
authors.forename: A
authors.initials: A
authors.lastname: Stripsanelli
authors.forename: A
authors.initials: A
authors.lastname: Arka
authors.forename: P
authors.initials: P
authors.lastname: Kostamis
mesh_terms: D000818:Animals; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000493:pharmacokinetics*; D051379:Mice; D011877:Radionuclide Imaging; D013667:Technetium / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D016756:Immunoglobulins, Intravenous; D013667:Technetium