title: An autopsy case of fetal Gaucher disease.
abstract: BACKGROUND
  A case of fetal form of Gaucher disease in a Japanese fetus is presented.
  
  
  RESULTS
  A macerated baby showing hydrops fetalis was dissected at 29 weeks of gestation. The fetus was heavier in the body, liver and spleen than a normal fetus at the same gestation period. It also suffered from pericardial effusion and ascites. The diagnosis of Gaucher disease was made by histological and biochemical findings. In microscopical examinations 'Gaucher cells', which were periodic acid-Shiff (PAS)-positive, alcian blue-positive and CD68-positive, existed in the lungs, liver, spleen, thymus, adrenal glands, bone marrow and brain. In thin layer chromatography, a large quantity of glucocerebroside was seen to have accumulated in the patient's organs.
authors.affiliation: First Department of Pathology, Kansai Medical University, Moriguchi, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Adachi
authors.forename: Y
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: H
authors.initials: H
authors.lastname: Ida
authors.forename: R
authors.initials: R
authors.lastname: Yasumizu
authors.forename: A
authors.initials: A
authors.lastname: Okamura
authors.forename: H
authors.initials: H
authors.lastname: Kayatani
authors.forename: N
authors.initials: N
authors.lastname: Teranishi
authors.forename: M
authors.initials: M
authors.lastname: Inaba
authors.forename: A
authors.initials: A
authors.lastname: Sugihara
authors.forename: H
authors.initials: H
authors.lastname: Genba
authors.forename: Y
authors.initials: Y
authors.lastname: Eto
authors.forename: S
authors.initials: S
authors.lastname: Ikehara
mesh_terms: D000328:Adult; D005260:Female; D005776:Gaucher Disease / Q000196:embryology* / Q000473:pathology; D005963:Glucosylceramides / Q000032:analysis; D006801:Humans
chemical_list: D005963:Glucosylceramides