Budd-Chiari syndrome, portal vein and mesenteric vein thrombosis in a patient homozygous for factor V Leiden mutation treated by TIPS and thrombolysis.
We present the first case of Budd-Chiari syndrome in association with portal and mesenteric vein thrombosis in a patient homozygous for the factor V Leiden mutation. She was treated by transjugular intrahepatic portosystemic stent (TIPS) placement followed by local thrombolytic therapy. Venous outflow from the liver was established and the thrombi in the portal and mesenteric veins were lysed completely. This therapeutic approach may be used for such patients with this severe thrombotic event, who generally have a poor prognosis.
Leebeek
F W
FW
Department of Haematology, University Hospital Rotterdam Dijkzigt, The Netherlands.
Lameris
J S
JS
van Buuren
H R
HR
Gomez
E
E
Madretsma
S
S
Sonneveld
P
P
D000328:Adult; D006502:Budd-Chiari Syndrome / Q000235:genetics / Q000628:therapy*; D003131:Combined Modality Therapy; D005165:Factor V / Q000235:genetics*; D005260:Female; D006801:Humans; D008641:Mesenteric Vascular Occlusion / Q000628:therapy; D008642:Mesenteric Veins; D009154:Mutation; D011169:Portal Vein; D019168:Portasystemic Shunt, Transjugular Intrahepatic; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000628:therapy
C095381:factor V Leiden; D005165:Factor V