title: Segregation of transcription and replication sites into higher order domains.
abstract: Microscopy shows that individual sites of DNA replication and transcription of mammalian nuclei segregate into sets of roughly 22 and 16 higher order domains, respectively. Each domain set displayed a distinct network-like appearance, including regions of individual domains and interdigitation of domains between the two networks. These data support a dynamic mosaic model for the higher order arrangement of genomic function inside the cell nuclei.
authors.affiliation: Department of Biological Sciences, State University of New York at Buffalo, Buffalo, NY 14260, USA.
authors.forename: X
authors.initials: X
authors.lastname: Wei
authors.forename: J
authors.initials: J
authors.lastname: Samarabandu
authors.forename: R S
authors.initials: RS
authors.lastname: Devdhar
authors.forename: A J
authors.initials: AJ
authors.lastname: Siegel
authors.forename: R
authors.initials: R
authors.lastname: Acharya
authors.forename: R
authors.initials: R
authors.lastname: Berezney
mesh_terms: D016475:3T3 Cells; D000818:Animals; D002460:Cell Line; D002466:Cell Nucleolus / Q000378:metabolism / Q000648:ultrastructure; D002467:Cell Nucleus / Q000378:metabolism* / Q000648:ultrastructure; D004261:DNA Replication; D016678:Genome; D015894:Genome, Human; D006801:Humans; D007091:Image Processing, Computer-Assisted; D051379:Mice; D018613:Microscopy, Confocal; D008954:Models, Biological; D016196:S Phase; D014158:Transcription, Genetic