title: Proton spectroscopy without water suppression: the oversampled J-resolved experiment.
abstract: A method is introduced for obtaining proton spectra in vivo with all the advantages of a full water signal. The method, based on F1 oversampled J-resolved spectroscopy, makes it possible to separate metabolite signals from unwanted baseline artifacts. The dominant water resonance is used as a 2D reference signal for the phase-sensitive reconstruction of the 2D J-resolved metabolite spectra. The powerful specificity of this method is demonstrated with model compound spectra, phantoms, and in vivo examples.
authors.affiliation: GE Medical Systems, Fremont, California 94539, USA.
authors.forename: R E
authors.initials: RE
authors.lastname: Hurd
authors.forename: D
authors.initials: D
authors.lastname: Gurr
authors.forename: N
authors.initials: N
authors.lastname: Sailasuta
mesh_terms: D000328:Adult; D001921:Brain / Q000378:metabolism*; D018698:Glutamic Acid / Q000378:metabolism; D005973:Glutamine / Q000378:metabolism; D006801:Humans; D007091:Image Processing, Computer-Assisted; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D019047:Phantoms, Imaging; D012016:Reference Values; D012815:Signal Processing, Computer-Assisted; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D018377:Neurotransmitter Agents; D005973:Glutamine; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid