title: Interleukin-1beta in synovial fluid from the arthritic temporomandibular joint and its relation to pain, mobility, and anterior open bite.
abstract: OBJECTIVE
  The purpose of this study was to investigate whether interleukin-1beta in synovial fluid or blood plasma is involved in the development of pain or hyperalgesia of the temporomandibular joint (TMJ), as well as reduced mandibular mobility and anterior open bite.
  
  
  METHODS
  Twenty-nine patients with TMJ arthritis and seven healthy subjects were studied. VAS measurement of TMJ tenderness on palpation of the TMJ (TDP), TMJ pressure pain threshold and tolerance level (PPTL), mandibular mobility, pain during joint movements, and degree of anterior open bite (AOB) were assessed. IL-1beta levels were analyzed in TMJ synovial fluid (SF-IL-1beta) and blood samples and correlated with the preceding factors.
  
  
  RESULTS
  SF-IL-1beta showed significant positive correlations with VAS measurement of pain, TDP, and AOB and a negative correlation with PPTL.
  
  
  CONCLUSIONS
  This study indicates that IL-1beta in the synovial fluid is associated with pain and hyperalgesia in the TMJ region as well as an anterior open bite. Concerning the latter condition, IL-1beta seems to be a warning signal of tissue destruction.
authors.affiliation: Department of Clinical Oral Physiology, School of Dentistry, Karolinska Institutet, Huddinge, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Alstergren
authors.forename: M
authors.initials: M
authors.lastname: Ernberg
authors.forename: M
authors.initials: M
authors.lastname: Kvarnström
authors.forename: S
authors.initials: S
authors.lastname: Kopp
mesh_terms: D000328:Adult; D000368:Aged; D001168:Arthritis / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000032:analysis*; D008297:Male; D008310:Malocclusion / Q000209:etiology*; D008334:Mandible / Q000503:physiopathology*; D008875:Middle Aged; D009068:Movement; D010146:Pain / Q000209:etiology*; D013582:Synovial Fluid / Q000737:chemistry*; D013704:Temporomandibular Joint / Q000378:metabolism*; D013705:Temporomandibular Joint Disorders / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D007375:Interleukin-1