Mechanisms of the origin of chromosomal aberrations.
This manuscript gives a selective survey of some aspects of the origin of chromosomal aberrations (CA). The following topics are discussed: heterogeneity regarding the induction of initial DNA lesions and their repair among chromosomes or regions of the same chromosome, ratio between symmetrical and asymmetrical exchanges, influence of DNA repeats, chromatin condensation and cell-cycle checkpoints on the formation of chromosome alterations.
Palitti
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Department of Agrobiology and Agrochemistry, University of Tuscia, Via San Camillo de Lellis, s.n., I-01100 Viterbo, Italy. palitti@unitus.it
D002453:Cell Cycle / Q000502:physiology; D002843:Chromatin / Q000378:metabolism; D002869:Chromosome Aberrations; D019457:Chromosome Breakage / Q000235:genetics; D004249:DNA Damage / Q000235:genetics; D004260:DNA Repair / Q000235:genetics; D004720:Endonucleases / Q000378:metabolism; D009153:Mutagens / Q000494:pharmacology; D011839:Radiation, Ionizing; D016615:Telomere / Q000235:genetics
D002843:Chromatin; D009153:Mutagens; D004720:Endonucleases