title: Unexpected difference in enantioselective retention on cellulase (CHB I) silica stationary phase caused by exchange of potassium for sodium ion in the mobile phase.
abstract: An increase in both retention and enantioselectivity for some beta-blocking agents was observed when exchanging potassium to sodium ion in the buffer used as mobile phase. A large effect of ionic strength on retention was observed, while the enantioselectivity was constant.
authors.affiliation: Department of Pharmaceutical Chemistry, Uppsala University, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Hedeland
authors.forename: S
authors.initials: S
authors.lastname: Jönsson
authors.forename: R
authors.initials: R
authors.lastname: Isaksson
authors.forename: C
authors.initials: C
authors.lastname: Pettersson
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000737:chemistry; D002021:Buffers; D002480:Cellulase / Q000737:chemistry*; D008790:Metoprolol / Q000737:chemistry; D010096:Oxprenolol / Q000737:chemistry; D011188:Potassium / Q000737:chemistry*; D012822:Silicon Dioxide; D012964:Sodium / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism; D013696:Temperature
chemical_list: D000319:Adrenergic beta-Antagonists; D002021:Buffers; D010096:Oxprenolol; D012822:Silicon Dioxide; D012964:Sodium; D002480:Cellulase; D008790:Metoprolol; D011188:Potassium