[Antiprotease and immunostimulating effect of peptide components isolated from cuticle of the chicken stomach].
Peptides with molecular weights of 0.8 to 16 kDa were isolated from the keratinous envelope of chicken muscular stomach cuticle. The peptide preparation had a immunostimulating activity whose qualitative and quantitative traits made it comparable with the activity of known drugs of similar composition. In addition, the peptide preparation reversibly inactivated trypsin and activated chymotrypsin. A low-molecular-weight protein (14.1 kDa) was isolated from the peptide preparation by affinity chromatography on trypsin-Sepharose 4B. This protein was found to be a reversible noncompetitive inhibitor of trypsin.
Pivnenko
T N
TN
Pacific Fishery Research Center, Vladivostok, Russia.
Epshteĭn
L M
LM
Okladnikova
S V
SV
Gazha
A K
AK
Besednova
N N
NN
D000276:Adjuvants, Immunologic / Q000302:isolation & purification*; D000818:Animals; D002645:Chickens; D002846:Chromatography, Affinity; D051379:Mice; D008970:Molecular Weight; D010455:Peptides / Q000302:isolation & purification*; D011480:Protease Inhibitors / Q000302:isolation & purification*; D013278:Stomach, Avian / Q000737:chemistry*
D000276:Adjuvants, Immunologic; D010455:Peptides; D011480:Protease Inhibitors