title: Historical evolution of hypothermic liver surgery.
abstract: The clinical application of hypothermia dates back to the surgical treatment of blue babies (1949) and the early days of open heart surgery (1952), when generalized cooling was employed. The induction of hepatic hypothermia began with whole-body cooling in experimental models in 1953 and clinically in 1961. It was designed to minimize the ischemia-reperfusion injury associated with hepatic inflow occlusion. Body surface cooling and cooling via an extracorporeal circuit, however, were not widely accepted for hepatic surgery because of the adverse effects on the extrahepatic organs. Consequently, with the introduction of improved venovenous bypass techniques, in situ cold hepatic perfusion has been used in selected patients since 1971. In situ hypothermic hemihepatic perfusion, introduced in 1995, prevents an ischemic insult to the contralateral hepatic lobe. Topical cooling using ice slush under total or hemihepatic inflow occlusion was reported in 1993. This technique does not require cumbersome hypothermic perfusion equipment. In attempts to minimize intraoperative bleeding by vascular occlusion, the liver surgeon must consider the benefits and technical demands of hepatic hypothermia.
authors.affiliation: First Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Yamanaka
authors.forename: C L
authors.initials: CL
authors.lastname: Dai
authors.forename: E
authors.initials: E
authors.lastname: Okamoto
mesh_terms: D000818:Animals; D016063:Blood Loss, Surgical / Q000517:prevention & control; D006348:Cardiac Surgical Procedures / Q000266:history; D004195:Disease Models, Animal; D004899:Erythroblastosis, Fetal / Q000266:history; D005112:Extracorporeal Circulation / Q000266:history; D006498:Hepatectomy / Q000266:history*; D049673:History, 20th Century; D006801:Humans; D007036:Hypothermia, Induced / Q000266:history* / Q000379:methods; D007231:Infant, Newborn; D008102:Liver Circulation; D015427:Reperfusion Injury / Q000266:history / Q000517:prevention & control