title: Histopathologic and immunohistochemic correlations in virus B chronic hepatitis.
abstract: Complete diagnosis of chronic hepatitis relies on exploring the liver by bipsic punction, performing the classic histopathologic and immunohistochemic exams. We worked out viral antigens hepatocytes by using avidin-biotin-peroxidase complex technique as following: Ag HBs placed in cytoplasm or at the level of the cell membrane. Ag HBc preferably placed in nucleus and, a small part of it, in cytoplasm. Ag HD present especially in nucleus. A correlation between tissular antigen expression and hepatic histopathologic aspect was established. Two main types of viral expression were remarked: a regressive type reflected by cytoplasmatic Ag HBs in the absence of generalised nuclear Ag HBc--situations linked to persistent chronic hepatitis: an aggressive type characterised by the presence of the focal nuclear Ag HBc, cytoplasmatic Ag HBc or antigen HD--situations linked to active chronic hepatitis with various degrees of severity.
authors.affiliation: County Clinical Hospital, Craiova.
authors.forename: V
authors.initials: V
authors.lastname: Comănescu
authors.forename: C
authors.initials: C
authors.lastname: Ardeleanu
authors.forename: B
authors.initials: B
authors.lastname: Zaharia
authors.forename: M
authors.initials: M
authors.lastname: Florescu
authors.forename: C
authors.initials: C
authors.lastname: Simionescu
authors.forename: C
authors.initials: C
authors.lastname: Comănescu
mesh_terms: D001707:Biopsy, Needle; D003593:Cytoplasm / Q000473:pathology; D006512:Hepatitis B Core Antigens / Q000032:analysis; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D019694:Hepatitis B, Chronic / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000473:pathology*
chemical_list: D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens