title: Phosphorelay signalling: new tricks for an ancient pathway.
abstract: 'Two-component' phosphorelay systems, once thought to be used exclusively by prokaryotes, have in the past few years been shown to exist in eukaryotes. A two-component system in Dictyostelium has now been shown to modulate protein kinase A, a key regulator of multicellular development in this organism.
authors.affiliation: Department of Biology, University of California, San Diego, La Jolla 92093-0634, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Brown
authors.forename: R A
authors.initials: RA
authors.lastname: Firtel
mesh_terms: D000818:Animals; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism*; D004023:Dictyostelium / Q000502:physiology*; D008954:Models, Biological; D010766:Phosphorylation; D015398:Signal Transduction / Q000502:physiology*; D013170:Spores
chemical_list: D017868:Cyclic AMP-Dependent Protein Kinases