title: Ibuprofen-induced hepatotoxicity in patients with chronic hepatitis C: a case series.
abstract: Hepatitis C is a common chronic infection. Nonsteroidal anti-inflammatory drugs are commonly ingested both over-the-counter and by prescription. This case report describes three cases where ibuprofen use leads to a marked rise in hepatic transaminases with one case repeating on rechallenge. These cases support the recommendation of acetaminophen over nonsteroidal antiinflammatory drug use in patients with chronic hepatitis C.
authors.affiliation: Penn State Geisinger Health System, The Milton S. Hershey Medical Center, The Pennsylvania State University, Department of Medicine, Hershey 17033-0850, USA.
authors.forename: T R
authors.initials: TR
authors.lastname: Riley
authors.forename: J P
authors.initials: JP
authors.lastname: Smith
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001219:Aspartate Aminotransferases / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology*; D004796:Clinical Enzyme Tests; D019698:Hepatitis C, Chronic / Q000150:complications*; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects*; D008297:Male
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D007052:Ibuprofen