[The use of fluoride in the treatment of osteoporosis].
Fluorides salts are used in the treatment for osteoporosis for 30 years, since their anabolic action on trabecular bone is well documented, but safety and efficacy of this treatment is still debated. Fluoride administration results in increased number and level of activity of osteoblasts leading to thicker trabeculae. The highest fluoride concentration and activity can be found within newly formed osteoid. Recommended dose is 15-25 mg per day, that is 33-55 mg of sodium fluoride or 140-190 of Na2FPo3. Calcium and vitamin D should be prescribed to all patients concurrently. Most frequent side effects include bone pain and dyspeptic problems.
Bohatyrewicz
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Katedry i Kliniki Ortopedii i Traumatologii PAM w Szczecinie.
D045930:Anabolic Agents / Q000627:therapeutic use*; D002118:Calcium / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005459:Fluorides / Q000627:therapeutic use*; D006801:Humans; D010024:Osteoporosis / Q000188:drug therapy*; D014807:Vitamin D / Q000627:therapeutic use
D045930:Anabolic Agents; D014807:Vitamin D; D005459:Fluorides; D002118:Calcium