Laryngeal glycogenic acanthosis presenting as leukoplakia.
We report a case of an incidental finding of glycogenic acanthosis of the larynx on autopsy in a 79-year-old man who died of myocardial infarction. The lesion was grossly recognized as a white plaque (leukoplakia) on the subglottic compartment of the left side of the larynx. Histological sections revealed thickened squamous mucosa positive for abundant glycogen on periodic acid-Schiff staining. No epithelial dysplasia was noted. The patient had a history of smoking. This case represents the first report of glycogenic acanthosis involving the larynx. This benign condition should be added to the vast differential diagnosis of leukoplakia in this anatomical location.
Fyfe
B S
BS
Department of Pathology and Laboratory Medicine, Allegheny University-Hahnemann, MCP-Hahnemann School of Medicine, Philadelphia, PA 19102-1192, USA. Fyfe@AUHS.edu
Garcia
F U
FU
D000368:Aged; D003937:Diagnosis, Differential; D006003:Glycogen / Q000032:analysis; D006801:Humans; D007818:Laryngeal Diseases / Q000473:pathology*; D007820:Laryngeal Mucosa / Q000737:chemistry / Q000473:pathology; D007971:Leukoplakia / Q000473:pathology*; D008297:Male
D006003:Glycogen