title: Interassay calibration as a major contribution to the comparability of results in clinical enzymology.
abstract: OBJECTIVE
  Factors contributing to the applicability of interassay calibration of methods measuring enzyme catalytic activities are described. Also discussed are the properties essential for such a material. Similarity of specificity for the methods to be calibrated as well as commutability between the material(s) intended to be used as calibrator are the main criteria to be satisfied.
  
  
  RESULTS
  Several examples demonstrated that interassay calibration is feasible but a multi-enzyme calibrator with a wide commutability for the most popular methods remains to be developed. This is the project of the IFCC Working Group on Calibrators in Clinical Enzymology (WG-CCE). Several experimental data are also presented that indicate that the temperature at which the reaction is carried out is not a limiting factor in the implementation of interassay calibration in clinical enzymology.
authors.affiliation: Laboratoire de Biochimie Appliquée, Faculté de Pharmacie, Université Louis Pasteur, Illkirch, France.
authors.forename: G
authors.initials: G
authors.lastname: Férard
authors.forename: J
authors.initials: J
authors.lastname: Edwards
authors.forename: T
authors.initials: T
authors.lastname: Kanno
authors.forename: J M
authors.initials: JM
authors.lastname: Lessinger
authors.forename: D W
authors.initials: DW
authors.lastname: Moss
authors.forename: F
authors.initials: F
authors.lastname: Schiele
authors.forename: N W
authors.initials: NW
authors.lastname: Tietz
authors.forename: A
authors.initials: A
authors.lastname: Vassault
mesh_terms: D002138:Calibration; D019411:Clinical Laboratory Techniques / Q000592:standards*; D004798:Enzymes / Q000032:analysis* / Q000592:standards; D006801:Humans; D012015:Reference Standards; D013696:Temperature
chemical_list: D004798:Enzymes