title: Epidemiology and prognosis in children treated for intracranial tumours in Denmark 1960-1984.
abstract: A total of 911 Danish children under 15 years of age were treated for an intracranial tumour in the 25-five year period 1960-1984. All cases were followed up to the end of 1994 or to emigration or death if one of these came sooner. The mean annual incidence was 32.5 per million children with a slight increase over the 25 years. The male/female ratio was 1.15 and close to the M/F ratio for the entire Danish population of children. Of the tumours, 46% were located in the supratentorial and 54% in the infratentorial compartment, and 94% were verified histologically. In order of frequency the most common types were astrocytomas (all grades, 35%), medulloblastomas (20%), ependymomas (14%), and craniopharyngiomas (5%). Total removal of the tumour was performed in 277 and partial removal, including biopsy, in 490 children. In 57 patients a shunt operation only was performed, and 87 children did not have an operation or died before the correct diagnosis was established. Radiotherapy was administered in 55%. The outcome depended on extent of removal, radiation, location and histology of the tumour. Most (784 or 86%) of the children survived more than 1 month after diagnosis or operation, and 353 children (39% of the whole series, 47% of those alive more than 1 month after diagnosis) were alive at follow-up. Of the survivors 29% had a tumour in the supratentorial midline, 26% one in the lateral part of the supratentorial area, 31% a cerebellar tumour and 13% a IV ventricle tumour. It was possible for 66% of the survivors with supratentorial and 90% of those with infratentorial tumours to lead a normal life. The long-term prognosis was especially good for children with cerebellar and supratentorial astrocytomas and optic chiasma tumours. Children with juvenile cerebellar astrocytoma had the best prognosis: 90% were alive at the end of the follow-up period, as against 20% of those with medulloblastoma and 6% of those with glioblastoma. A comparison of the data from the present series and from a similar Danish series of intracranial tumours in 533 children seen in the years 1935-1959 shows no significant differences in location or histology, a slight increase in annual incidence, and improved survival rates during the 50 years in question.
authors.affiliation: Neuroscience Centre, University Clinic of Neurosurgery, Rigshospitalet, Copenhagen, Denmark. gjerris@rh.dk
authors.forename: F
authors.initials: F
authors.lastname: Gjerris
authors.forename: N
authors.initials: N
authors.lastname: Agerlin
authors.forename: S E
authors.initials: SE
authors.lastname: Børgesen
authors.forename: L
authors.initials: L
authors.lastname: Buhl
authors.forename: J
authors.initials: J
authors.lastname: Haase
authors.forename: L
authors.initials: L
authors.lastname: Klinken
authors.forename: A C
authors.initials: AC
authors.lastname: Mortensen
authors.forename: J H
authors.initials: JH
authors.lastname: Olsen
authors.forename: N
authors.initials: N
authors.lastname: Ovesen
authors.forename: E
authors.initials: E
authors.lastname: Reske-Nielsen
authors.forename: K
authors.initials: K
authors.lastname: Schmidt
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D001932:Brain Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D003718:Denmark; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D011379:Prognosis; D017678:Sex Distribution; D016019:Survival Analysis