Novel betaines from the marine sponge Agelas dispar.
Three novel betaine alkaloids, called aminozooanemonin (1), pyridinebetaine A (2), and pyridinebetaine B (3), have been isolated from the Caribbean sponge Agelas dispar. Their structures were determined by FABMS, IR, UV, and 1D and 2D NMR spectroscopic experiments. Aminozooanemonin and pyridinebetaine A showed moderate antibacterial activity.
Cafieri
F
F
Dipartimento di Chimica delle Sostanze Naturali, via D. Montesano 49, I-80131 Napoli, Italy.
Fattorusso
E
E
Taglialatela-Scafati
O
O
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001622:Betaine / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011161:Porifera / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000900:Anti-Bacterial Agents; D001622:Betaine