Polymorphic imprinting of the serotonin-2A (5-HT2A) receptor gene in human adult brain.
We have examined the imprinting status of the serotonin-2A (5-HT2A) receptor gene (HTR2A) in a series of 41 tissue samples from human adult brain. Using a HpaII RFLP polymorphism in the coding region, we obtained evidence of monoallelic expression of HTR2A in 4 out of 18 informative individuals. However, biallelic expression of HTR2A was observed in other individuals (14/18), suggesting that within the human population HTR2A imprinting in brain is polymorphic.
Bunzel
R
R
Institute of Human Genetics, University of Bonn, Wilhelmstr. 31, D-53111, Bonn, Germany.
Blümcke
I
I
Cichon
S
S
Normann
S
S
Schramm
J
J
Propping
P
P
Nöthen
M M
MM
D000483:Alleles; D001921:Brain / Q000378:metabolism*; D018392:Genomic Imprinting; D006801:Humans; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000235:genetics*
D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin