title: Xenopus eomesodermin is expressed in neural differentiation.
abstract: Our initial description of the Xenopus gene Eomesodermin (Eomes) indicated that it is expressed largely if not entirely in mesodermal cells of gastrula stage embryos. A more detailed examination, described here, shows that it continues to be expressed in the most anterior (future head) mesoderm during gastrula and neurula stages. However, during tail-bud stages, Eomes expression is re-born in the most anterior part of the brain, becoming strongly transcribed in the olfactory region of the telencephalon. This later Eomes expression marks a very localized region of the forebrain distinct from that of Otx-2, anterior to that of En-1 and overlapping that of Sox-3.
authors.affiliation: Wellcome/CRC Institute, Tennis Court Road, Cambridge, CB2 1QR, UK.
authors.forename: K
authors.initials: K
authors.lastname: Ryan
authors.forename: K
authors.initials: K
authors.lastname: Butler
authors.forename: E
authors.initials: E
authors.lastname: Bellefroid
authors.forename: J B
authors.initials: JB
authors.lastname: Gurdon
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D004268:DNA-Binding Proteins; D004625:Embryo, Nonmammalian / Q000378:metabolism; D047108:Embryonic Development; D018507:Gene Expression Regulation, Developmental; D006609:High Mobility Group Proteins; D018398:Homeodomain Proteins; D017403:In Situ Hybridization; D009419:Nerve Tissue Proteins / Q000235:genetics; D009420:Nervous System / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D051857:Otx Transcription Factors; D055748:SOXB1 Transcription Factors; D020825:T-Box Domain Proteins; D015534:Trans-Activators / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics*; D014981:Xenopus / Q000196:embryology / Q000235:genetics*; D029867:Xenopus Proteins
chemical_list: D004268:DNA-Binding Proteins; C103223:EOMES protein, Xenopus; C081542:En1 protein, Xenopus; D006609:High Mobility Group Proteins; D018398:Homeodomain Proteins; D009419:Nerve Tissue Proteins; D051857:Otx Transcription Factors; D055748:SOXB1 Transcription Factors; C527788:Sox3 protein, Xenopus; D020825:T-Box Domain Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D029867:Xenopus Proteins