Antibiotic hypersensitivity reactions in cystic fibrosis.
OBJECTIVE
To document the frequency and severity of reactions to antibiotics in children and adolescents with cystic fibrosis (CF), to determine which drugs and routes of administration are most likely to produce reactions and to assess how these reactions limit the choice of antibiotics.


METHODS
Medical records were reviewed to ascertain the number and routes of courses of antibiotics and all suspected drug reactions. Patients and their parents were interviewed about drug reactions.


RESULTS
Fifty-three records were suitable for analysis. Eighteen of 53 subjects had experienced a reaction (34%). The intravenous route was most allergenic, with 33% of treated patients experiencing a reaction and 9.5% of courses provoking a reaction. Piperacillin was the most allergenic antibiotic.


CONCLUSIONS
Drug hypersensitivity reactions are common in CF. Piperacillin is particularly allergenic. Whilst rarely life-threatening, the reactions are unpleasant and can limit our choices for antibiotic treatment of their bronchopneumonia.
Wills
R
R
John Hunter Children's Hospital, New Lambton Heights, New South Wales, Australia.
Henry
R L
RL
Francis
J L
JL
D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000150:complications*; D004333:Drug Administration Routes; D004342:Drug Hypersensitivity / Q000150:complications*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010406:Penicillins / Q000009:adverse effects; D010878:Piperacillin / Q000009:adverse effects; D012141:Respiratory Tract Infections / Q000150:complications / Q000188:drug therapy; D012189:Retrospective Studies
D000900:Anti-Bacterial Agents; D010406:Penicillins; D010878:Piperacillin