The Drosophila Pax gene eye gone is required for embryonic salivary duct development.
What are the developmental mechanisms required for conversion of an undifferentiated, two-dimensional field of cells into a patterned, tubular organ? In this report, we describe the contribution of the Drosophila Pax gene eye gone to the development of the embryonic salivary glands and ducts. eye gone expression in salivary tissues is controlled by several known regulators of salivary fate. After the initial establishment of the salivary primordium by Sex combs reduced, fork head excludes eye gone expression from the pregland cells so that its salivary expression is restricted to the posterior preduct cells. trachealess, in contrast, activates eye gone expression in the posterior preduct cells. We have previously described the process by which fork head and the EGF receptor pathway define the border between the gland and duct primordia. Here we show that eye gone is required for the subdivision of the duct primordium itself into the posterior individual duct and the anterior common duct domains. In the absence of eye gone, individual ducts as well as the precursor of the adult salivary glands, the imaginal ring, are absent. We took advantage of this ductless phenotype to show that Drosophila larvae do not have an obligate requirement for salivary glands and ducts. In addition to its role in the salivary duct, eye gone is required in the embryo for the development of the eye-antennal imaginal disc and the chemosensory antennal organ.
Jones
N A
NA
Division of Genetics, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA.
Kuo
Y M
YM
Sun
Y H
YH
Beckendorf
S K
SK
D000818:Animals; D001426:Bacterial Proteins; D002135:Calcium-Binding Proteins; D004330:Drosophila / Q000196:embryology* / Q000235:genetics; D029721:Drosophila Proteins; D051858:Forkhead Transcription Factors; D018507:Gene Expression Regulation, Developmental; D006360:Heat-Shock Proteins / Q000502:physiology; D006460:Hemolysin Proteins / Q000502:physiology; D018398:Homeodomain Proteins / Q000502:physiology*; D019476:Insect Proteins / Q000502:physiology; D036341:Intercellular Signaling Peptides and Proteins; D000072100:Jagged-1 Protein; D008565:Membrane Proteins / Q000502:physiology; D009687:Nuclear Proteins / Q000502:physiology; D011505:Protein-Tyrosine Kinases; D017468:Receptors, Fibroblast Growth Factor / Q000502:physiology; D018987:Salivary Ducts / Q000196:embryology* / Q000502:physiology; D012469:Salivary Glands / Q000196:embryology / Q000502:physiology; D012679:Sense Organs / Q000196:embryology; D000072099:Serrate-Jagged Proteins; D014157:Transcription Factors / Q000502:physiology*
D001426:Bacterial Proteins; D002135:Calcium-Binding Proteins; D029721:Drosophila Proteins; D051858:Forkhead Transcription Factors; D006360:Heat-Shock Proteins; D006460:Hemolysin Proteins; D018398:Homeodomain Proteins; D019476:Insect Proteins; D036341:Intercellular Signaling Peptides and Proteins; D000072100:Jagged-1 Protein; D008565:Membrane Proteins; D009687:Nuclear Proteins; D017468:Receptors, Fibroblast Growth Factor; C059627:Scr protein, Drosophila; C000606278:Ser protein, Drosophila; D000072099:Serrate-Jagged Proteins; D014157:Transcription Factors; C088609:thermostable direct hemolysin-related hemolysin protein, Vibrio parahaemolyticus; C102301:BTL protein, Drosophila; D011505:Protein-Tyrosine Kinases