[The blood serum albumin transport function in patients with acute and chronic leukemias].
OBJECTIVE
The study of changes in functional activity of albumin ligand centers in the course of accumulation of metabolic products in the blood of hematological patients.


METHODS
Blood serum albumin transport function (TF) was investigated in 22 and 24 patients with acute and chronic leukemia, respectively. Lipid analyser AKL-01 and the kit "Zond-Albumin" ("Zond", Moscow) were employed to assess total albumin concentration (TAC), effective albumin concentration (EAC), albumin binding reserve (ABR), the toxicity index (TI). The control group consisted of 38 blood donors. The findings were processed with statistical techniques.


RESULTS
In patients with manifest acute leukemia, ABR and TI decreased while TAC remained unchanged. Chronic leukemia patients had high EAC and close to control levels of ABR and TI. In terminal chronic leukemia ABR lowered, TI increased, TAC was high but EAC fell. In patients with chronic leukemia and acute leukemia remission changes in albumin TF was accompanied with growing TAC.


CONCLUSIONS
A decline of albumin TF was found in patients with manifest acute leukemia and terminal chronic leukemia. In non-terminal chronic leukemia and in remission of acute leukemia albumin TF was normal.
Litvinov
A V
AV
Savchenko
V G
VG
Tsepova
E L
EL
Chemodurova
L N
LN
D000208:Acute Disease; D001692:Biological Transport; D001782:Blood Donors; D005260:Female; D006801:Humans; D007938:Leukemia / Q000097:blood*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood; D008024:Ligands; D008297:Male; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism*
D008024:Ligands; D012709:Serum Albumin