Complex regulation of multiple cytohesin-like genes in murine tissues and cells.
Three cytohesin-like cDNA molecules were isolated from murine ES cell derived embryoid bodies. The genomic structure of one of the three, CLM2, has been determined and transcriptional variants of each were isolated from a mouse brain cDNA library. The relative expression patterns of CLM1, 2, 3 and their transcriptional alternatives were determined by RT-PCR, nucleotide sequencing and RNA blotting. Their broad distribution and cell and tissue specific expression patterns suggest complex regulation during development and in the adult.
Kim
H S
HS
Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel.
Chen
Y
Y
Lonai
P
P
D016475:3T3 Cells; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015815:Cell Adhesion Molecules / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics*; D003001:Cloning, Molecular; D017931:DNA Primers; D018076:DNA, Complementary; D005091:Exons; D020690:GTPase-Activating Proteins; D005786:Gene Expression Regulation; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D009928:Organ Specificity; D016133:Polymerase Chain Reaction; D051381:Rats; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D013234:Stem Cells / Q000502:physiology*; D014158:Transcription, Genetic
D015815:Cell Adhesion Molecules; D017931:DNA Primers; D018076:DNA, Complementary; D020690:GTPase-Activating Proteins; C102474:cytohesin-2