title: Epidural fentanyl reduces the shivering threshold during epidural lidocaine anesthesia.
abstract: Epidural local anesthetics and IV opioids both decrease the core temperature that triggers shivering. However, the effect of epidural opioids on shivering thresholds has not been assessed. In this study, we tested the hypothesis that adding epidural fentanyl to epidural lidocaine decreases the shivering threshold compared with epidural lidocaine alone. Fourteen healthy male patients undergoing extracorporeal shockwave lithotripsy under epidural anesthesia were randomly assigned to receive either epidural lidocaine or epidural lidocaine plus epidural fentanyl. Ice-cold lactated Ringer's solution was given IV before epidural blockade, and the core temperature that triggers shivering was established. Then epidural anesthesia was induced, and the shivering threshold was established again after lithotripsy. Results were analyzed using paired or unpaired t-tests. Reduction in the shivering threshold by epidural anesthesia was significantly greater when fentanyl was added to lidocaine than when lidocaine was used alone (mean +/- SD: -0.6+/-0.4 degrees C versus -0.1+/-0.4 degrees C; P < 0.02). We conclude that patients are at increased risk of hypothermia when fentanyl is added to epidural lidocaine.
  
  
  CONCLUSIONS
  Fentanyl is often added to lidocaine to improve the quality of epidural blockade and to reduce side effects. However, this study shows that patients are at increased risk of hypothermia when fentanyl is added to lidocaine.
authors.affiliation: Department of Anaesthesia, St. Vincent's Hospital, Fitzroy, Australia.
authors.forename: J M
authors.initials: JM
authors.lastname: Wheelahan
authors.forename: K
authors.initials: K
authors.lastname: Leslie
authors.forename: B S
authors.initials: BS
authors.lastname: Silbert
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000494:pharmacology*; D000767:Anesthesia, Epidural; D000779:Anesthetics, Local; D001831:Body Temperature / Q000187:drug effects; D005283:Fentanyl / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007036:Hypothermia, Induced; D008012:Lidocaine; D008096:Lithotripsy; D008297:Male; D012768:Shivering / Q000187:drug effects*
chemical_list: D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D008012:Lidocaine; D005283:Fentanyl