title: Effect of insecticides on vital activity, hepatic enzymes and red blood cell acetyl cholinesterase activity of rabbits in Makkah.
abstract: Developing animals and invertebrate are markedly more sensitive to acute toxicity through exposure to insecticides. Varieties of insecticides are used for hygienic control in Makkah holy places. The present study examines the acute effects of commonly used insecticides in Makkah area. Rosfin as an organophosphorus, Airlen as a pyrethroid and Sulvac as a carbamate derivative were tested for their effects on vital activities, hepatic transaminases, serum triglycerides and acetyl cholinesterase activity of rabbits. The insecticides were tested in same and double concentration used for insect control by Makkah's municipal authorities. Compressed air was used as a source of pressure for spraying wooden boxes designed for habitation of animals during the experiments. There were no significant changes in vital activities of rabbits in both concentrations. However, serum glutamate pyuvate transaminase (SGPT) and serum glutamate oxaloacetate transaminase (SGOT) showed irregular changes (mild decrease or increase) in all groups, while triglyceride showed mild rise after six days exposure in case of double concentration. Acetyl cholinesterase showed mild increase in activity after five minutes incubation time, but there was unnoticed increase in activity after 15, 25, 35 and 45 minutes of incubation. In case of Airlen, the activity increased after five minutes of incubation and decreased thereafter. In conclusion, insecticides used in the holy places of Makkah area have no apparent effects on vital activity, acetyl cholinesterase activity and showed no significant effect on rabbit hepatic transaminases and serum triglyceride.
authors.affiliation: Pharmacology and Toxicology Section, Faculty of Medicine and Medical Sciences, Umm Al-Qura University, Makkah Al-Mukarramah, Saudi Arabia.
authors.forename: A H
authors.initials: AH
authors.lastname: Sawas
mesh_terms: D000110:Acetylcholinesterase / Q000187:drug effects*; D000410:Alanine Transaminase / Q000187:drug effects*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical; D004912:Erythrocytes / Q000201:enzymology*; D006801:Humans; D019570:Inhalation Exposure / Q000009:adverse effects*; D007300:Insect Control / Q000379:methods*; D007306:Insecticides / Q000009:adverse effects*; D007514:Islam; D011817:Rabbits / Q000097:blood; D012529:Saudi Arabia; D013997:Time Factors; D014280:Triglycerides / Q000097:blood*; D005723:gamma-Glutamyltransferase / Q000187:drug effects*
chemical_list: D007306:Insecticides; D014280:Triglycerides; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000110:Acetylcholinesterase