title: Population based case-control study of sick leave in postmenopausal women before diagnosis of hyperparathyroidism.
abstract: OBJECTIVE
  To analyse sick leave in women at risk of primary hyperparathyroidism before its diagnosis.
  
  
  METHODS
  Case-control study nested within a screened cohort of postmenopausal women. Cases were women with hyperparathyroidism without prior knowledge of their disease and no traditional symptoms or complications. Controls were women from the screened population without hyperparathyroidism.
  
  
  METHODS
  Population based screening within a Swedish community.
  
  
  METHODS
  48 case-control pairs of women aged 55-70 years.
  
  
  METHODS
  Sick leave during the 5 years before diagnosis.
  
  
  RESULTS
  Total duration of sickness benefits was longer in the cases than controls, and this discrepancy included sick leave on full time or half time and for periods of longer than a week. Cases had an increased risk of sick leave more than half of the investigated time compared with controls (odds ratio 12). Doctors' certificates showed that the overrepresented sick leave in the cases related mainly to cardiovascular diseases.
  
  
  CONCLUSIONS
  Asymptomatic mild primary hyperparathyroidism in postmenopausal women is accompanied by a previously unrecognised morbidity, which has consequences for clinical management of the disorder and its impact on the health economy.
authors.affiliation: Department of Surgery, Uppsala University, S-751 85 Uppsala, Sweden. ewa.lundgren@kirurgi.uu.se
authors.forename: E
authors.initials: E
authors.lastname: Lundgren
authors.forename: E
authors.initials: E
authors.lastname: Szabo
authors.forename: S
authors.initials: S
authors.lastname: Ljunghall
authors.forename: R
authors.initials: R
authors.lastname: Bergström
authors.forename: L
authors.initials: L
authors.lastname: Holmberg
authors.forename: J
authors.initials: J
authors.lastname: Rastad
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000175:diagnosis* / Q000453:epidemiology; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D017698:Postmenopause; D018582:Sick Leave / Q000706:statistics & numerical data*; D013548:Sweden / Q000453:epidemiology