Implications of lag time concept in the oxidation of LDL.
Oxidation of low density lipoprotein (LDL) has been implicated in the pathogenesis of atherosclerosis. The most common technique for measuring the oxidation of lipoproteins is the continuous measurement of the formation of conjugated diene at OD 234 nm. The concept of "lag time", derived from such measurements, has been used to test the efficacy of various antioxidants for their ability to inhibit the oxidation of LDL. This review will elaborate on some of the factors that might affect the lag time.
Parthasarathy
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Department of Gynecology and Obstetrics, Emory University, Atlanta, GA 30322, USA. spartha@emory.edu
Augé
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Santanam
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D000475:Alkenes / Q000032:analysis / Q000378:metabolism; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology; D001161:Arteriosclerosis / Q000378:metabolism*; D006801:Humans; D008074:Lipoproteins / Q000032:analysis* / Q000187:drug effects / Q000378:metabolism*; D010084:Oxidation-Reduction; D012307:Risk Factors; D013057:Spectrum Analysis / Q000379:methods*; D013997:Time Factors
D000475:Alkenes; D000975:Antioxidants; D008074:Lipoproteins