title: Coexistence of 3 tumors of neural crest origin: neurofibroma, meningioma, and uveal malignant melanoma.
abstract: OBJECTIVE
  To describe the clinical findings in a patient who developed a neurofibroma, meningioma, and choroidal melanoma.
  
  
  METHODS
  Clinical and histopathological findings of the case are reviewed and presented.
  
  
  RESULTS
  The patient had a right superolateral periorbital neurofibroma, a right sphenoid wing meningioma, and a left choroidal juxtapapillary malignant melanoma. All 3 tumors are derived from neural crest cells.
  
  
  CONCLUSIONS
  To our knowledge, this is the first report of a patient with this combination of 3 neural crest-derived tumors. This case is most appropriately classified as a complex neurocristopathy, a disorder involving the aberrant and pathological proliferation of multiple tissues derived from neural crest cells.
authors.affiliation: Department of Ophthalmology, Wright State University School of Medicine, Dayton, Ohio 45429-3487, USA.
authors.forename: R E
authors.initials: RE
authors.lastname: Warwar
authors.forename: J D
authors.initials: JD
authors.lastname: Bullock
authors.forename: J A
authors.initials: JA
authors.lastname: Shields
authors.forename: R C
authors.initials: RC
authors.lastname: Eagle
mesh_terms: D002830:Choroid Neoplasms / Q000473:pathology* / Q000601:surgery; D015353:Eye Enucleation; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008545:Melanoma / Q000473:pathology* / Q000601:surgery; D008577:Meningeal Neoplasms / Q000473:pathology* / Q000601:surgery; D008579:Meningioma / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000601:surgery; D009432:Neural Crest / Q000473:pathology*; D009455:Neurofibroma / Q000473:pathology* / Q000601:surgery; D009918:Orbital Neoplasms / Q000473:pathology* / Q000601:surgery