title: First-pass metabolism of cyclosporine A in human intestine: inhibition by diltiazem.
authors.affiliation: Clinic for Cardiothoracic Surgery, University of Regensburg, Germany.
authors.forename: J G
authors.initials: JG
authors.lastname: Preuner
authors.forename: K
authors.initials: K
authors.lastname: Lehle
authors.forename: H
authors.initials: H
authors.lastname: Eichinger
authors.forename: L
authors.initials: L
authors.lastname: Rupprecht
mesh_terms: D000284:Administration, Oral; D001711:Biotransformation; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D016572:Cyclosporine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D004110:Diltiazem / Q000627:therapeutic use*; D004347:Drug Interactions; D006207:Half-Life; D016027:Heart Transplantation / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D007275:Injections, Intravenous; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D014018:Tissue Distribution
chemical_list: D002121:Calcium Channel Blockers; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D004110:Diltiazem