title: Negative correlation between plasma fibrinogen and insulin sensitivity measured with the minimal model technique.
abstract: We aimed at investigating relationship between plasma fibrinogen and insulin sensitivity, which are two major determinants of metabolic Syndrome X (insulin resistance syndrome). We designed a prospective study of 27 non-diabetic, non-hypertensive subjects, presenting a wide range of body mass index BMI (10 men, 17 women; mean age+/-SEM: 35.9+/-2.2 years; BMI ranging from 21.1-45.2 kg/m2). Insulin sensitivity was assessed with the minimal model procedure, over a 180 min intravenous glucose tolerance test with iterative sampling. Fibrinogen levels were determined by the method of Clauss. The insulin sensitivity index SI (i.e., the slope of the dose-response relationship between insulin increased above baseline and glucose disposal) ranged from 0.0009 to 16 x 10(-4) min(-1)/(microU/ml), with a mean value of 4.76+/-0.73 x 10(-4). Mean values of plasma fibrinogen were 3.33+/-0.13 g/l, ranging from 2.21 to 5.07 g/l. There were highly significant negative correlations between SI and the level of plasma fibrinogen (r = -0.61, p = 0.0007) and between the basal effect of insulin BIE and plasma fibrinogen (r = -0.521, p = 0.005). Basal insulin was positively correlated to fibrinogen (r = 0.386, p = 0.046). When we analysed the data using partial correlation analysis, the negative relation between SI and fibrinogen was maintained independently from BMI (r = -0.45, p < 0.05). These data establish a strong negative association between insulin sensitivity and fibrinogen, involved in the increased cardiovascular risk of metabolic Syndrome X.
authors.affiliation: Laboratoire de Biochimie, Faculté de Pharmacie, Montpellier, France.
authors.forename: E
authors.initials: E
authors.lastname: Raynaud
authors.forename: J F
authors.initials: JF
authors.lastname: Brun
authors.forename: A
authors.initials: A
authors.lastname: Perez-Martin
authors.forename: A
authors.initials: A
authors.lastname: Orsetti
authors.forename: M
authors.initials: M
authors.lastname: Solère
mesh_terms: D000328:Adult; D005260:Female; D005340:Fibrinogen / Q000032:analysis*; D018056:Hemorheology; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D013577:Syndrome
chemical_list: D005340:Fibrinogen