title: Absorption of cholesterol oxidation products from ordinary foodstuff in humans.
abstract: BACKGROUND
  Information on the absorption of cholesterol oxidation products (COP) from ordinary foodstuff in humans is scarce.
  
  
  METHODS
  Five healthy young men were offered a salami- and Parmesan-containing meal naturally rich in COP. Plasma and lipoprotein COP concentrations were measured over the following 9 h.
  
  
  RESULTS
  The mean plasma free (nonesterified) COP concentration showed its maximal increase 3 and 5 h after meal consumption. In contrast, the raise in plasma total COP concentration began 6 h after the meal with a maximum at 8 h and was statistically significant for 7alpha- and 7beta-hydroxycholesterol and 7-ketocholesterol. The increase in plasma total cholesterol concentration was comparable to that of total COP. Comparing the COP composition of the chylomicrons and the test meal, cholestanetriol, 7-ketocholesterol, and to a lesser extent cholesterol-alpha-epoxide were underrepresented in the chylomicrons as was the opposite for 7beta-hydroxycholesterol. In very-low-density lipoprotein, a steady increase in the COP:cholesterol ratio was observed from 6 h on.
  
  
  CONCLUSIONS
  COP from ordinary foodstuff were absorbed in the human intestinal tract but differences in the bioavailability of the single COP compounds were found.
authors.affiliation: Institute of Nutrition Science of the Technical University of Munich, Germany. linseise@server.ernwiss.agrar.tu-muenchen.de
authors.forename: J
authors.initials: J
authors.lastname: Linseisen
authors.forename: G
authors.initials: G
authors.lastname: Wolfram
mesh_terms: D000042:Absorption; D000328:Adult; D002611:Cheese; D002784:Cholesterol / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*; D002914:Chylomicrons; D005502:Food; D006801:Humans; D006888:Hydroxycholesterols / Q000493:pharmacokinetics; D007653:Ketocholesterols / Q000493:pharmacokinetics; D007700:Kinetics; D008297:Male; D008461:Meat Products; D010084:Oxidation-Reduction
chemical_list: D002914:Chylomicrons; D006888:Hydroxycholesterols; D007653:Ketocholesterols; C011724:cholest-5-en-3 beta,7 alpha-diol; D002784:Cholesterol; C003001:7-ketocholesterol