Expression of human transferrin receptor is controlled by a gene on chromosome 3: assignment using species specificity of a monoclonal antibody.
The monoclonal antibody OKT-9 has been shown to recognize the human transferrin receptor. We have exploited the species specificity of OKT-9 to map a gene controlling human transferrin receptor expression to chromosome 3, using human-mouse somatic cell hybrids. The gene for the human transferrin receptor and the gene controlling transferrin expression may be linked in humans.
Goodfellow
P N
PN
Imperial Cancer Research Fund, London, U.K.
Banting
G
G
Sutherland
R
R
Greaves
M
M
Solomon
E
E
Povey
S
S
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3; D003429:Cross Reactions; D005786:Gene Expression Regulation; D006801:Humans; D007457:Iodine Radioisotopes; D051379:Mice; D011233:Precipitin Tests; D011863:Radioimmunoassay; D011990:Receptors, Transferrin / Q000235:genetics* / Q000276:immunology*; D013045:Species Specificity
D000911:Antibodies, Monoclonal; D007457:Iodine Radioisotopes; D011990:Receptors, Transferrin