Striatal lesions produce distinctive impairments in reaction time performance in two different operant chambers.
The dorsal striatum plays a crucial role in mediating voluntary movement. Excitotoxic striatal lesions in rats have previously been shown to impair the initiation but not the execution of movement in a choice reaction time task in an automated lateralised nose-poke apparatus (the "nine-hole box"). Conversely, when a conceptually similar reaction time task has been applied in a conventional operant chamber (or "Skinner box"), striatal lesions have been seen to impair the execution rather than the initiation of the lateralised movement. The present study was undertaken to compare directly these two results by training the same group of rats to perform a choice reaction time task in the two chambers and then comparing the effects of a unilateral excitotoxic striatal lesion in both chambers in parallel. Particular attention was paid to adopting similar parameters and contingencies in the control of the task in the two test chambers. After striatal lesions, the rats showed predominantly contralateral impairments in both tasks. However, they showed a deficit in reaction time in the nine-hole box but an apparent deficit in response execution in the Skinner box. This finding confirms the previous studies and indicates that differences in outcome are not simply attributable to procedural differences in the lesions, training conditions or tasks parameters. Rather, the pattern of reaction time deficit after striatal lesions depends critically on the apparatus used and the precise response requirements for each task.
Brasted
P J
PJ
MRC Cambridge Centre for Brain Repair, University of Cambridge, UK. pjb34@cus.cam.ac.uk
Döbrössy
M D
MD
Robbins
T W
TW
Dunnett
S B
SB
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D003213:Conditioning, Psychological / Q000502:physiology; D004195:Disease Models, Animal; D018690:Excitatory Amino Acid Agonists; D006816:Huntington Disease / Q000139:chemically induced / Q000503:physiopathology; D008297:Male; D009046:Motor Neurons / Q000502:physiology; D009068:Movement / Q000502:physiology; D017072:Neostriatum / Q000166:cytology / Q000502:physiology*; D017378:Quinolinic Acid; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000502:physiology*
D018690:Excitatory Amino Acid Agonists; D017378:Quinolinic Acid