title: Effect of estrogen and progesterone on newly synthesised and released human fallopian tube specific proteins.
abstract: Current study was carried out to identify the profile of newly synthesized and released proteins by human fallopian tube (hFT). Results indicated that hFT during menopause synthesised and released only 2-3 proteins as against several proteins ranging from molecular weight (MW) approximately 20 to approximately 130 kD during normal menstrual cycle. In vitro addition of estradiol-17 beta (E2) resulted in synthesis and release of a number of proteins including specific protein of MW 110-130 kD. Addition of progesterone (P) however, led to inhibition of protein synthesis and a combination of E2 and P negated the effect of the latter. An alteration in oviductal secretory protein-profile following addition of E2 in vitro were similar to that observed during normal menstrual cycle.
authors.affiliation: Institute for Research in Reproduction (ICMR), Bombay, India.
authors.forename: A S
authors.initials: AS
authors.lastname: Shah
authors.forename: S
authors.initials: S
authors.lastname: Kundale
authors.forename: V P
authors.initials: VP
authors.lastname: Raghavan
authors.forename: T D
authors.initials: TD
authors.lastname: Nandedkar
authors.forename: I
authors.initials: I
authors.lastname: Hinduja
authors.forename: S V
authors.initials: SV
authors.lastname: Parulekar
authors.forename: U
authors.initials: U
authors.lastname: Natraj
mesh_terms: D046508:Culture Techniques; D004967:Estrogens / Q000494:pharmacology*; D005187:Fallopian Tubes / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D006801:Humans; D008715:Methionine / Q000378:metabolism; D011374:Progesterone / Q000494:pharmacology*; D014176:Protein Biosynthesis; D011506:Proteins / Q000378:metabolism
chemical_list: D004967:Estrogens; D011506:Proteins; D011374:Progesterone; D008715:Methionine