title: Administration of methylprednisolone acetate into the subdural cavity in an infant with subdural fluid collection. PAF is a good indicator of the efficacy of the treatment.
abstract: We report on the successful treatment of a case of infantile subdural fluid collection after cardiac surgery by administration of methylprednisolone acetate into the subdural cavity. The protein content in subdural fluid did not change even after administration of this steroid and was not a good indicator of the efficacy of treatment; however, the content of platelet-activating factor (PAF), an inflammatory mediator, in the fluid removed from the subdural cavity decreased rapidly after administration of the steroid. Subdural fluid collection subsequently decreased and mental retardation was improved. Our findings suggest that PAF content is a good indicator of the severity of infantile subdural fluid collection.
authors.affiliation: Department of Neurosurgery, Toyama Medical and Pharmaceutical University, Sugitani, Japan. sendo@ms.toyama-mpu.ac.jp
authors.forename: S
authors.initials: S
authors.lastname: Endo
authors.forename: Y
authors.initials: Y
authors.lastname: Hirashima
authors.forename: M
authors.initials: M
authors.lastname: Takaba
authors.forename: A
authors.initials: A
authors.lastname: Takaku
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D001927:Brain Diseases / Q000188:drug therapy*; D006348:Cardiac Surgical Procedures; D004322:Drainage; D005260:Female; D006801:Humans; D007223:Infant; D007427:Intracranial Pressure; D008775:Methylprednisolone / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D000077555:Methylprednisolone Acetate; D010972:Platelet Activating Factor / Q000134:cerebrospinal fluid*; D011183:Postoperative Complications; D013353:Subdural Effusion / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed
chemical_list: D000893:Anti-Inflammatory Agents; D015415:Biomarkers; D010972:Platelet Activating Factor; D000077555:Methylprednisolone Acetate; D008775:Methylprednisolone