title: Symptomatic pulmonary hyalinizing granuloma.
abstract: An otherwise healthy 37-year-old man came to the emergency room with left-sided dull chest pain of 4 weeks' duration. Physical examination, laboratory studies, and electrocardiogram were all unremarkable. A chest x-ray film revealed calcified pulmonary nodules. Computed tomography of the chest confirmed bilateral parenchymal cavitary lesions. Via limited thoracotomy, a tan nodule measuring 2.5 to 3.0 cm in diameter was excised from the left upper lobe. Histopathologic examination revealed a well circumscribed lesion and extensive lamellar hyalinization. A few foci of finely granular calcification were present within the hyalinizing areas. After surgery and short-term use of nonnarcotic analgesics, the chest pain resolved. Although pulmonary hyalinizing granuloma (PHG) is known to produce cavitating lesions, calcification at multiple sites is also consistent with this diagnosis. Clinicians should remember to include PHG in the differential diagnosis of multiple pulmonary nodules.
authors.affiliation: Department of Internal Medicine, James H. Quillen College of Medicine, East Tennessee State University, Johnson City 37614-0622, USA.
authors.forename: J
authors.initials: J
authors.lastname: Ramirez
authors.forename: J B
authors.initials: JB
authors.lastname: Mehta
authors.forename: R A
authors.initials: RA
authors.lastname: Taylor
authors.forename: R P
authors.initials: RP
authors.lastname: Byrd
authors.forename: T M
authors.initials: TM
authors.lastname: Roy
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D015769:Granuloma, Respiratory Tract / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D006818:Hyalin / Q000378:metabolism; D008171:Lung Diseases / Q000175:diagnosis* / Q000378:metabolism; D008297:Male