Congenital toxoplasma gondii infection diagnosed by PCR amplification of peripheral mononuclear blood cells from a child and mother.
A case of congenital toxoplasmosis is presented, where diagnosis by PCR amplification of Toxoplasma gondii DNA from peripheral blood led to early treatment of the infant and seemingly normal brain development despite the presence of intracranial calcifications at birth. The mother, who experienced a subclinical infection during pregnancy, was PCR-positive for toxoplasma DNA in a sample of peripheral blood drawn after delivery.
Bergström
T
T
Department of Clinical Virology, Göteborg University, Sweden.
Ricksten
A
A
Nenonen
N
N
Lichtenstein
M
M
Olofsson
S
S
D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D001483:Base Sequence; D016054:DNA, Protozoan / Q000032:analysis*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007963:Leukocytes, Mononuclear; D008297:Male; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction / Q000379:methods*; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000097:blood / Q000175:diagnosis*; D012680:Sensitivity and Specificity; D012698:Serologic Tests; D014122:Toxoplasma / Q000302:isolation & purification*; D014125:Toxoplasmosis, Congenital / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy
D000981:Antiprotozoal Agents; D016054:DNA, Protozoan