Synergism between poly-(1-6)-beta-D-glucopyranosyl-(1-3)-beta-D-glucopyranose glucan and cefazolin in prophylaxis of staphylococcal wound infection in a guinea pig model.
To determine whether the infection-preventing capability of the neutrophil-activating agent poly-(1-6)-beta-D-glucopyranosyl-(1-3)-beta-D-glucopyranose glucan (PGG-glucan) can be enhanced with antibiotic prophylaxis, we administered PGG-glucan and cefazolin, alone and in combination, to guinea pigs inoculated with isolates of staphylococci. Guinea pigs receiving both PGG-glucan and cefazolin had 50% infective doses that were 8- to 20-fold higher than those obtained with cefazolin alone and 100- to 200-fold higher than those obtained with PGG-glucan alone. PGG-glucan and cefazolin are synergistic in their ability to prevent staphylococcal wound infection.
Kaiser
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Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2605, USA. allen.kaiser@mcmail.vanderbilt.edu
Kernodle
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D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D019072:Antibiotic Prophylaxis; D002437:Cefazolin / Q000008:administration & dosage / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D004357:Drug Synergism; D005260:Female; D005936:Glucans / Q000008:administration & dosage / Q000627:therapeutic use*; D006168:Guinea Pigs; D008297:Male; D013203:Staphylococcal Infections / Q000517:prevention & control*; D014946:Wound Infection / Q000517:prevention & control*; D047071:beta-Glucans
D000276:Adjuvants, Immunologic; D002511:Cephalosporins; D005936:Glucans; D047071:beta-Glucans; C069894:poly-1-6-glucopyranosyl-1-3-glucopyranose glucan; D002437:Cefazolin