Inhibitory effects of rebamipide on ENNG-induced duodenal carcinogenesis in mice: a possible strategy for chemoprevention of gastrointestinal cancers.
Rebamipide is a potent antioxidative agent; it increases gastric mucosal PGE2 production and thus protects the gastric mucosa. We hypothesized that the mechanisms of ulcer formation could be extended to carcinogenesis and that an increase in gastric mucosal protection may result in a decrease in gastric carcinogenesis. Therefore, we assessed the inhibitory effects of rebamipide on N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) -induced carcinogenesis in mice. The percentage of tumor-bearing mice in three treatment groups--ENNG + rebamipide 20 mg, ENNG + rebamipide 50 mg, and ENNG alone--was 55%, 42%, and 67%, respectively. The incidence of tumorigenesis tended to decrease with increasing doses of rebamipide. The difference between ENNG + rebamipide 50 mg and ENNG alone was statistically significant (P < 0.05). These results suggest that rebamipide may strengthen the host defense mechanisms related to carcinogenesis in the digestive tract.
Yamane
T
T
First Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
Nakatani
H
H
Matsumoto
H
H
Iwata
Y
Y
Kikuoka
N
N
Takahashi
T
T
D000409:Alanine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002273:Carcinogens / Q000037:antagonists & inhibitors*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004379:Duodenal Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000031:analogs & derivatives* / Q000737:chemistry; D051379:Mice; D008810:Mice, Inbred C57BL; D015363:Quinolones / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D002273:Carcinogens; D015363:Quinolones; D008769:Methylnitronitrosoguanidine; C013525:ENNG; C052785:rebamipide; D000409:Alanine