State-dependent stimulus control: cuing attributes of acute cocaine rebound in rats.
Sprague-Dawley (Rattus norvegicus) rats were trained in a drug discrimination task using the state-dependent interoceptive stimulus attributes of cocaine's delayed or rebound effects (CDE) versus "normal" basal homeostasis. Rats were injected with either 32 mg/kg cocaine or equivalent volumes of saline (SAL), subcutaneously, 13 hr before the sessions. Rats demonstrated > 90% discriminative accuracy. Test sessions showed a time-dependent acute cocaine isodirectional rebound state that engendered a shift from predominantly SAL- to CDE-appropriate responding approximately 7 hr after the high training dose injection and lasted for approximately 10 hr (17 hr postinjection). The delayed or rebound state was dose dependent and engendered only a biphasic partial generalization with acute cocaine injections. There were no detectable levels of cocaine or any of its behaviorally active metabolites at the 13-hr postinjection interval. Tests conducted with various doses of lidocaine, chlordiazepoxide, N-methyl-d-aspartic acid, ketamine, and buspirone engendered SAL- or default-appropriate responding. The anxiogenic drug, pentylenetetrazole, produced partial generalization to the cocaine rebound cue.
Gauvin
D V
DV
Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, Oklahoma City 73190-3000, USA.
Vanecek
S A
SA
Baird
T J
TJ
Briscoe
R J
RJ
Vallett
M
M
Carl
K L
KL
Wasielewski
J A
JA
Holloway
F A
FA
D000818:Animals; D002707:Chlordiazepoxide / Q000494:pharmacology; D003042:Cocaine / Q000097:blood / Q000494:pharmacology*; D004192:Discrimination, Psychological; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D016202:N-Methylaspartate / Q000494:pharmacology; D009294:Narcotics / Q000097:blood / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012646:Self Administration
D009294:Narcotics; D016202:N-Methylaspartate; D002707:Chlordiazepoxide; D008012:Lidocaine; D003042:Cocaine