Correlation between cytomegalovirus infection and IgM anti-MAG/SGPG antibody-associated neuropathy.
IgM anti-myelin-associated glycoprotein (anti-MAG)/sulfated glucuronyl paragloboside (SGPG) antibody is found in some patients with chronic polyneuropathy (CP). An antigen-driven process is considered to induce this autoantibody, but the agent has yet to be identified. It has been reported that sera from cytomegalovirus (CMV)-infected patients contained anti-SGPG antibody. To clarify the mechanism of the production of the anti-MAG/SGPG antibody, we investigated CMV DNA in sera from 26 patients with IgM anti-MAG/SGPG antibody-positive CP. Twenty-three (88%) had CMV DNA. The positive frequency was significantly higher than the frequencies in sera from patients with IgM anti-MAG/SGPG-negative CP, the other disease controls, and the normal control subjects. There were no statistical differences in the frequencies of Epstein-Barr virus DNA between anti-MAG/SGPG-positive and anti-MAG/SGPG-negative CP and between anti-MAG/SGPG-positive CP and each disease control. Moreover, no herpes simplex virus 1 DNA was detected in the sera from patients with anti-MAG/SGPG-positive CP. The strong correlation of anti-MAG/SGPG-positive CP with the presence of serum CMV DNA suggests that CMV infection induces the IgM anti-MAG/SGPG antibody.
Yuki
N
N
Department of Neurology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan.
Yamamoto
T
T
Hirata
K
K
D001323:Autoantibodies / Q000096:biosynthesis; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000097:blood / Q000276:immunology*; D004279:DNA, Viral / Q000097:blood; D005915:Globosides / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000096:biosynthesis / Q000097:blood*; D018992:Myelin-Associated Glycoprotein / Q000276:immunology*; D010523:Peripheral Nervous System Diseases / Q000276:immunology* / Q000821:virology
D001323:Autoantibodies; D004279:DNA, Viral; D005915:Globosides; D007075:Immunoglobulin M; D018992:Myelin-Associated Glycoprotein; C051917:sulfate-3-glucuronyl paragloboside