title: Cocaine use early in treatment predicts outcome in a behavioral treatment program.
abstract: In this evaluation of baseline drug use as a predictor of treatment outcome, cocaine use during a 5-week baseline was compared in methadone maintenance patients who had < 5 (n = 10) versus > or = 5 (n = 9) weeks of abstinence during an experimental cocaine abstinence reinforcement treatment. Cocaine use was evaluated at the 1st and last visit and the 1st and last week of baseline and as a mean across the 5-week baseline treatment; response was calculated as a mean across 12 weeks of experimental treatment. Those who had successful outcomes (abstainers) used significantly less cocaine in the 5-week baseline than those with less successful outcomes (nonabstainers). Differences in cocaine use were not evident in the 1st baseline visit or week, but the abstainers used significantly less cocaine in the last visit and week of baseline compared with the nonabstainers. Cocaine use during baseline provided critical predictors of response to the experimental treatment.
authors.affiliation: Intramural Research Program, National Institute on Drug Abuse (NIDA), Baltimore, Maryland 21224, USA. kpreston@intra.nida.nih.gov
authors.forename: K L
authors.initials: KL
authors.lastname: Preston
authors.forename: K
authors.initials: K
authors.lastname: Silverman
authors.forename: S T
authors.initials: ST
authors.lastname: Higgins
authors.forename: R K
authors.initials: RK
authors.lastname: Brooner
authors.forename: I
authors.initials: I
authors.lastname: Montoya
authors.forename: C R
authors.initials: CR
authors.lastname: Schuster
authors.forename: E J
authors.initials: EJ
authors.lastname: Cone
mesh_terms: D000328:Adult; D001521:Behavior Therapy / Q000379:methods*; D003042:Cocaine / Q000008:administration & dosage* / Q000009:adverse effects; D019970:Cocaine-Related Disorders / Q000150:complications / Q000628:therapy*; D005260:Female; D005544:Forecasting / Q000379:methods; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008691:Methadone / Q000627:therapeutic use; D008875:Middle Aged; D009294:Narcotics / Q000008:administration & dosage* / Q000009:adverse effects; D009293:Opioid-Related Disorders / Q000534:rehabilitation; D016896:Treatment Outcome
chemical_list: D009294:Narcotics; D003042:Cocaine; D008691:Methadone