title: [Cancer of the thyroid gland with mediastinal extension].
abstract: OBJECTIVE
  Thyroid carcinomas with upper mediastinal invasion are rare: 24 out of 1,204 thyroid carcinomas operated in the Cancer Center Hospital of Shanghai (2%). For this reason, the report of our experience seems useful.
  
  
  METHODS
  The 24 patients (13 male and 11 female) had a mean age of 45 years. Ten patients presented symtoms, nine had a palpable cervical mass and in five, the lesion was discovered by an upper mediastinal scan. The operation was performed through an upper partiel sternotomy (n = 12) associated with resection of the internal part of the clavicle (n = 8) and of the first two costal cartilages (n = 4). Tumoral removal was complete in 15 patients and incomplete in nine.
  
  
  RESULTS
  There were no peroperative and postoperative deaths. During the procedure, the "brachio-cephalique" vein was injured and sutured in three patients. During the postoperative period, a pneumothorax was observed in three patients and a mediastinal infection in two. When the tumor removal was incomplete (n = 9), postoperative radiotherapy was performed. The only patients with papillary thyroid carcinoma (n = 16) have survived more than 5 years. For the entire group of patients, the 5-year and 10-year survival rate was respectively 65% and 47%. After incomplete tumoral resection followed by radiotherapy, two patients survived with a 28-year follow-up.
  
  
  CONCLUSIONS
  This experience demonstrates that patients may survive beyond 10 years, even after incomplete resection of thyroid carcinoma with upper mediastinal invasion, if the carcinoma is differentiated.
authors.affiliation: Centre anticancéreux, université médicale de Shangai, Shangai Cancer Hospital, Chine.
authors.forename: Y
authors.initials: Y
authors.lastname: Wu
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D012086:Reoperation; D013249:Sternum / Q000601:surgery; D013964:Thyroid Neoplasms / Q000473:pathology / Q000601:surgery*; D013965:Thyroidectomy / Q000379:methods*; D016896:Treatment Outcome