[Vitiligo in multiple autoimmune syndrome: a retrospective study of 11 cases and a review of the literature].
OBJECTIVE
The occurrence in the same patient of three or more autoimmune diseases defines multiple autoimmune disease. Multiple autoimmune disease is an unusual condition in which dermatological autoimmune diseases and especially vitiligo have an important place.


METHODS
We examined retrospectively 11 cases of multiple autoimmune diseases associating vitiligo. We studied the clinical characteristics of vitiligo and those of the associated autoimmune disorders.


RESULTS
Type III multiple autoimmune disease was diagnosed in all the 11 cases observed. Autoimmune vitiligo was the first autoimmune disorder observed in seven cases and was bilateral, symmetrical and acrofacial in eight cases. Autoimmune thyroid disorder was associated in ten cases. Our data confirms the important association between vitiligo and thyroid autoimmune disorders.


CONCLUSIONS
The predominant female ratio and the acrofacial topography of skin lesions could predict association with others autoimmune disorders in patients with vitiligo.
Service de médecine interne, Hôpital Gabriel-Montpied, Clermont-Ferrand, France.
A
A
Klisnick
J
J
Schmidt
J L
JL
Dupond
K
K
Bouchou
H
H
Rousset
P
P
Thieblot
P
P
Humbert
E
E
Vidal
O
O
Aumaître
D000293:Adolescent; D000328:Adult; D001172:Arthritis, Rheumatoid / Q000150:complications; D001327:Autoimmune Diseases / Q000150:complications* / Q000503:physiopathology; D017675:CREST Syndrome / Q000150:complications; D002648:Child; D005148:Facial Dermatoses / Q000276:immunology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications; D008297:Male; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000150:complications; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications; D012189:Retrospective Studies; D012737:Sex Factors; D012859:Sjogren's Syndrome / Q000150:complications; D013577:Syndrome; D013967:Thyroiditis, Autoimmune / Q000276:immunology / Q000503:physiopathology; D014820:Vitiligo / Q000276:immunology* / Q000503:physiopathology
Le vitiligo au cours des syndromes auto-immuns multiples: étude rétrospective de 11 observations et revue de la littérature.