Treatment of mononeuropathy multiplex in hepatitis C virus and cryoglobulinemia.
Recent reports advocate alpha-interferon (alpha-Ifn) treatment for mononeuropathy multiplex in hepatitis C virus-associated cryoglobulinemia. We report 2 patients with this disorder to describe two underrecognized treatment outcomes--worsening of polyneuropathy with initiation of alpha-Ifn, in the absence of immunosuppression, and deterioration of liver function with prednisone, despite improvement of polyneuropathy.
Department of Neurology, Beth Israel Medical Center, Albert Einstein College of Medicine, New York, New York 10003, USA.
S N
SN
Scelsa
S
S
Herskovitz
B
B
Reichler
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D000998:Antiviral Agents / Q000008:administration & dosage; D003449:Cryoglobulinemia / Q000628:therapy / Q000821:virology*; D005260:Female; D006526:Hepatitis C / Q000150:complications* / Q000628:therapy; D006801:Humans; D016898:Interferon-alpha / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000502:physiology / Q000821:virology; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy* / Q000821:virology*; D011241:Prednisone / Q000008:administration & dosage*
D000893:Anti-Inflammatory Agents; D000998:Antiviral Agents; D016898:Interferon-alpha; D011241:Prednisone