Role of enkephalinergic brain structures in regulating motivated behavior in rats with lesioned serotoninergic neurons.
The behavioral effects of injections of enkephalin into the substantia nigra or dorsal raphe nucleus were studied in rats with lesioned serotoninergic structures. Lesions were produced by intracerebral administration of the neurotoxin 5,7-dihydroxytryptamine. Treated rats showed normalization of conditioned drinking reflex extinction. It is proposed that there is a tight connection between the normalizing effects of enkephalin on rat behavior in conditions of deficient brain serotoninergic system function and increases in the efficiency of presynaptic inhibition of dopaminergic neurons.
Laboratory for Conditioned Reflex Morphophysiology, Science Research Institute of the Brain, Russian Academy of Medical Sciences, Moscow, Russia.
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Shugalev
D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000166:cytology / Q000502:physiology*; D001923:Brain Chemistry / Q000502:physiology*; D003214:Conditioning, Classical / Q000502:physiology; D004298:Dopamine / Q000502:physiology; D004745:Enkephalins / Q000502:physiology*; D008297:Male; D009042:Motivation; D009474:Neurons / Q000502:physiology*; D011903:Raphe Nuclei / Q000166:cytology / Q000502:physiology; D051381:Rats; D012701:Serotonin / Q000502:physiology*; D018490:Serotonin Agents / Q000494:pharmacology; D013378:Substantia Nigra / Q000166:cytology / Q000502:physiology
D004745:Enkephalins; D018490:Serotonin Agents; D015116:5,7-Dihydroxytryptamine; D012701:Serotonin; D004298:Dopamine