[Histopathological diagnosis of Hodgkin's disease].
The diagnosis of Hodgkin's disease is based on histopathologic examination and the demonstration of Reed-Sternberg cells. These cells express antigens (Ki-1/CD30 CD15) which are of diagnostic value. Two types of Hodgkin's disease are now identified: 1. the "classical Hodgkin's disease" which includes nodular sclerosis, mixed cellularity and some tumors rich in malignant cells formerly designated Hodgkin's disease with lymphocyte depletion; 2. the "lymphocyte predominance Hodgkin's disease" in particular the nodular form (paragranuloma). These lesions are now considered an indolent form of B-cell lymphoma with possible transformation into large B-cell lymphoma. Epstein-Barr virus is involved in the "Classical Hodgkin's disease" but not in the "Lymphocyte predominance Hodgkin's disease". However, the role of Epstein-Barr virus in the occurrence of the disease and the prognostic implications of its detection remain ro be elucidated.
Laboratoire d'anatomie pathologique CHU Purpan, Toulouse.
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Delsol
D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006689:Hodgkin Disease / Q000175:diagnosis* / Q000276:immunology / Q000821:virology; D006801:Humans; D016130:Immunophenotyping; D017730:Ki-1 Antigen / Q000032:analysis; D016256:Lewis X Antigen / Q000032:analysis; D016393:Lymphoma, B-Cell / Q000175:diagnosis / Q000473:pathology; D016539:Reed-Sternberg Cells / Q000276:immunology / Q000473:pathology
D017730:Ki-1 Antigen; D016256:Lewis X Antigen
Diagnostic histopathologique de la maladie de Hodgkin.