[HLA haplotypes in young myocardial infarct patients (a family study)].
OBJECTIVE
Summarization of the results of family studies of inherited predisposition to myocardial infarction (MI) in young subjects from families with antigen Cw4 in phenotype.


METHODS
Young probands (32, 37 and 46 years of age) with MI and the family members were examined.


RESULTS
Antigen Cw4 predicts MI in young males living in the city of Kazan with MI hereditary load.


CONCLUSIONS
The findings enable localization of at least one gene involved in development of hereditary predisposition to MI in the group of HLA link on the short arm of human chromosome 6.
A A
AA
Kuz'mina
I A
IA
Latfullin
D000293:Adolescent; D000328:Adult; D002648:Child; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D003434:Crossing Over, Genetic / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics* / Q000276:immunology; D006680:HLA Antigens / Q000235:genetics*; D015236:HLA-C Antigens / Q000235:genetics; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics* / Q000276:immunology; D010641:Phenotype
D006680:HLA Antigens; D015236:HLA-C Antigens; C039966:HLA-C*04 antigen
Gaplotipy HLA u bol'nykh infarktom miokarda molodogo vozrasta (semeĭnye issledovanie).