Effect of Norplant on liver function.
Combined pills have known adverse effects on liver function. Progesterone based contraceptives are thought to be safer in this regard. The effect of Norplant, a levonorgestrel contraceptive implant, on liver function was evaluated in 149 Bangladeshi women of reproductive age in this study. Liver function tests and ultrasonography of hepato-biliary system were done before and after the implantation. The patients were followed upto two years. There were non-significant transient rise of serum bilirubin and slight enlargement of liver during the first year. There was no significant change in the levels of AST, ALT, alkaline phosphatase, total protein, albumin-globulin ratio and prothrombin time. The results suggest that Norplant has no adverse effect on liver function.
Deptt. of Obst. & Gyne, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine & Metabolic Disorders, Dhaka.
T A
TA
Chowdhury
M
M
Khan
S
S
Chowdhury
M
M
Rashid
L P
LP
Banu
S
S
Ali
D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001652:Bile Ducts / Q000000981:diagnostic imaging / Q000187:drug effects / Q000502:physiology; D001663:Bilirubin / Q000097:blood; D001798:Blood Proteins / Q000032:analysis; D003271:Contraceptive Agents, Female / Q000008:administration & dosage / Q000627:therapeutic use*; D004343:Drug Implants; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006984:Hypertrophy; D016912:Levonorgestrel / Q000008:administration & dosage / Q000627:therapeutic use*; D008099:Liver / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000502:physiology; D045167:Progesterone Congeners / Q000008:administration & dosage / Q000627:therapeutic use*; D011517:Prothrombin Time; D012709:Serum Albumin / Q000032:analysis; D012712:Serum Globulins / Q000032:analysis; D014463:Ultrasonography
D001798:Blood Proteins; D003271:Contraceptive Agents, Female; D004343:Drug Implants; D045167:Progesterone Congeners; D012709:Serum Albumin; D012712:Serum Globulins; D016912:Levonorgestrel; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin