Induction of ovarian tumors by heavy ion irradiation in B6C3F1 mice.
Six-week-old B6C3F1 mice were exposed to 0.439 Gy heavy ion irradiation as a 290 MeV/u carbon-ion beam (LET 10 keV/micron) at 2 cm from the upper proximal point of a spread Bragg beam and autopsied 13.5 months after the irradiation. In males total tumor incidences, mainly liver tumors, were 37.0% in irradiated group and 25.0% in control (P>0.05). In females the total tumor incidences were 32.3%, mainly ovarian tumors, in the irradiated group and 0% in the controls. These results indicate that heavy ion irradiation induces ovarian tumors in females but does not target any organ in males.
Watanabe
H
H
Department of Environment and Mutation, Research Institute for Radiation Biology and Medicine, Hiroshima University, Minami-ku, Hiroshima 734-8553, Japan.
Ogiu
T
T
Nishizaki
M
M
Fujimoto
N
N
Kido
S
S
Ishimura
Y
Y
Shiraki
K
K
Kuramoto
K
K
Hirata
S
S
Shoji
S
S
Katoh
O
O
D000311:Adrenal Glands / Q000528:radiation effects; D000818:Animals; D003433:Crosses, Genetic; D005260:Female; D020450:Heavy Ions; D007668:Kidney / Q000528:radiation effects; D008113:Liver Neoplasms / Q000209:etiology* / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D009929:Organ Size / Q000528:radiation effects; D010051:Ovarian Neoplasms / Q000209:etiology* / Q000473:pathology; D010053:Ovary / Q000528:radiation effects; D012727:Sex Characteristics; D013154:Spleen / Q000528:radiation effects; D013737:Testis / Q000528:radiation effects