[Extracellular proteases of stromal origin: contribution to tumor progression and therapeutic perspectives].
For a long time, extracellular proteinases were thought to be expressed by the cancerous cells and only able to cleave extracellular matrix components, in order to promote tumor cell invasion. Recent works have now demonstrated that these proteinases are currently synthesized by stromal fibroblastic cells and that some of them may exhibit additive function(s). These findings lead to a new therapeutical concept leading to target the activity of stromal proteinases, and most notably of the matrix metalloproteinases.
IGBMC, CNRS, INSERM, ULP, Illkirch.
M C
MC
Rio
R
R
Masson
M P
MP
Chenard
O
O
Lefebvre
A
A
Noël
P
P
Anglard
J P
JP
Bellocq
P
P
Basset
D010450:Endopeptidases / Q000378:metabolism*; D006801:Humans; D008666:Metalloendopeptidases / Q000378:metabolism; D009361:Neoplasm Invasiveness / Q000473:pathology / Q000503:physiopathology*; D009369:Neoplasms / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy*; D017154:Stromal Cells / Q000201:enzymology
D010450:Endopeptidases; D008666:Metalloendopeptidases
Les protéases extracellulaires d'origine stromale: contribution à la progression cancéreuse et perspectives thérapeutiques.