[Interaction central GABA-B receptors with serotoninergic brain system during regulation of the hypothalamo-hypophyseal-testicular axis by the negative feedback mechanism in rats].
The findings suggest that the GABA inhibits testosterone compensation after hemicastration, due to activation of the mediobasal hypothalamus serotoninergic system in Wistar rats. The GABA seems also to exert an activating effect via the GABA-receptors upon the hypothalamo-pituitary-testicular feedback regulation.
Institute of Cytology and Genetics of the Russian Acad. Sci., Siberian Branch, Novosibirsk, Russia.
A V
AV
Amikishieva
L I
LI
Serova
E V
EV
Naumenko
D000818:Animals; D001921:Brain / Q000378:metabolism / Q000502:physiology*; D005246:Feedback / Q000502:physiology; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D007031:Hypothalamus / Q000378:metabolism; D008297:Male; D008636:Mesencephalon / Q000378:metabolism; D009919:Orchiectomy; D051381:Rats; D017208:Rats, Wistar; D018080:Receptors, GABA-B / Q000502:physiology*; D012701:Serotonin / Q000378:metabolism*; D013737:Testis / Q000378:metabolism / Q000502:physiology*; D013739:Testosterone / Q000097:blood
D018080:Receptors, GABA-B; D012701:Serotonin; D013739:Testosterone
Vzaimodeĭstvie tsentral'nylh GAMK-B retseptorov s serotoninergicheskoĭ sistemoĭ golovnogo mozga krys v reguliatsii gipotalamo-gipofizarno-semennikovogo kompleksa mekhanizmom otritsatel'noĭ obratnoĭ sviazi.