[The role of the endogenous opioid system in regulation of the nonspecific resistance of the myocardium to reperfusion injury in rats].
Under conditions of postischemic reperfusion, significance of endogenous opioid receptors' agonists for regulation of the myocardial contractility becomes enhanced. The sigma-receptor blocking contributes to a decrease in postischemic contracture and preservation of the cardiac cell membrane integrity. In sigma-receptor blockade, reoxygenation contracture does not appear. Preliminary mu-receptor blocking leads to an almost complete restitution of the heart contractility and decreases sarcolemma damage during postischemic period.
Research Institute of Cardiology of the Russian Acad. Med. Sci., Siberian Branch, Tomsk, Russia.
L N
LN
Maslov
T V
TV
Lasukova
Iu B
IuB
Lishmanov
D000818:Animals; D003402:Creatine Kinase / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D017202:Myocardial Ischemia / Q000503:physiopathology; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology*; D009206:Myocardium / Q000378:metabolism; D009292:Narcotic Antagonists; D051381:Rats; D017208:Rats, Wistar; D011957:Receptors, Opioid / Q000502:physiology*; D017465:Receptors, Opioid, delta / Q000037:antagonists & inhibitors; D017473:Receptors, Opioid, kappa / Q000037:antagonists & inhibitors; D017450:Receptors, Opioid, mu / Q000037:antagonists & inhibitors; D017480:Receptors, sigma / Q000037:antagonists & inhibitors
D009292:Narcotic Antagonists; D011957:Receptors, Opioid; D017465:Receptors, Opioid, delta; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu; D017480:Receptors, sigma; D003402:Creatine Kinase
Rol' éndogennoĭ opioidnoĭ sistemy v reguliatsii nespetsificheskoĭ ustoĭchivosti miokarda k reperfuzionnomu povrezhdeniiu u krys.