Pharmacokinetics and oral bioavailability of glycopyrrolate in children.
Based on plasma levels determined with a radioreceptor assay and following a single oral (50 micrograms/kg) and intravenous (5 micrograms/kg) administration of glycopyrrolate in six healthy children operated twice during a several weeks period, a negligible and variable oral bioavailability was found (3.3; 1.3-13.3%) (median;range). No significant changes in heart rate after oral or intravenous administration of the drug could be seen. Oral glycopyrrolate appears to have no place in paediatric premedication.
Department of Anaesthesiology, Turku University Hospital, Finland.
P
P
Rautakorpi
T
T
Manner
T
T
Ali-Melkkilä
T
T
Kaila
K
K
Olkkola
J
J
Kanto
D000759:Adjuvants, Anesthesia / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D000284:Administration, Oral; D000293:Adolescent; D001682:Biological Availability; D002648:Child; D005260:Female; D006024:Glycopyrrolate / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D013511:Minor Surgical Procedures
D000759:Adjuvants, Anesthesia; D006024:Glycopyrrolate