Zinc transport from the striatum and substantia nigra.
65Zn was unilaterally injected into the striatum or substantia nigra of rats to see the transport of intracerebral zinc (Zn). In the case of intrastriatal injection, 65Zn was densely distributed in the ipsilateral medial forebrain bundle (MFB) and the substantia nigra. On unilateral colchicine injection into the MFB, 65Zn distribution in the ipsilateral substantia nigra decreased significantly compared to that of the contralateral one after 65Zn injection into the bilateral striata. These results suggest the presence of axonal transport of 65Zn taken up by striatonigral gamma-aminobutyric acid (GABA)-ergic and/or nigrostriatal dopaminergic neurons. On the other hand, in the case of intranigral injection, 65Zn was distributed in the ipsilateral MFB, striatum, globus pallidus, pontine reticular nuclei, and pontine nuclei. 65Zn distribution in the pons 1 day after intranigral injection was very similar to that 6 days after intrastriatal injection, suggesting that, in the case of intrastriatal injection of 65Zn, nigral 65Zn, which was transported anterogradely and/or retrogradely from the striatum, was transported to the postsynaptic neurons through the synapse and then transported to the pons.
Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Yada, Japan. takedaa@ys7.u-shizuoka-ken.ac.jp
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Takeda
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Kodama
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Ohnuma
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Okada
D000818:Animals; D001370:Axonal Transport / Q000187:drug effects / Q000502:physiology*; D003078:Colchicine / Q000494:pharmacology; D003342:Corpus Striatum / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013378:Substantia Nigra / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D015032:Zinc / Q000493:pharmacokinetics*
D015032:Zinc; D003078:Colchicine