Antagonism of kynurenic acid to anxiogens in mice.
In a dark-light chamber in mice, kynurenic acid (KYNA, 200 mg/kg, i.p.), an endogenous neuroactive metabolite of tryptophan, attenuated the most stable effect of anxiogens in this model of anxiety--a decrease in the rate of leanings-out of the dark compartment --induced by caffeine, pentylenetetrazole and yohimbine, but not by beta-phenylethylamine (PEA). KYNA by itself did not alter behavior of mice in the chamber, in contrast to what has been observed in an elevated plus-maze, another model of anxiety, where KYNA had an anxiolytic pharmacological profile.
Lapin
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Laboratory of Psychopharmacology, Bekhterev Psychoneurological Research Institute, St. Petersburg, Russia.
D000818:Animals; D001007:Anxiety / Q000139:chemically induced / Q000188:drug therapy; D001921:Brain / Q000187:drug effects; D002110:Caffeine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D007736:Kynurenic Acid / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D010627:Phenethylamines / Q000494:pharmacology; D015016:Yohimbine / Q000037:antagonists & inhibitors* / Q000494:pharmacology
D018691:Excitatory Amino Acid Antagonists; D010627:Phenethylamines; D015016:Yohimbine; C029261:phenethylamine; D002110:Caffeine; D007736:Kynurenic Acid; D003975:Diazepam; D010433:Pentylenetetrazole