In vitro activities of ampicillin-sulbactam and amoxicillin-clavulanic acid against Acinetobacter baumannii.
In vitro susceptibility patterns of newer beta-lactamase-inhibiting antibiotics ampicillin-sulbactam (A/S) and amoxicillin-clavulanic acid (A/C) for 100 consecutive isolates of Acinetobacter baumannii obtained from various clinical samples were studied. The A/C MIC for 86% of the strains was more than 16/8 microgram/ml, whereas there was an A/S MIC of more than 16/8 microgram/ml for only 38% of the strains. This showed that A/S has significantly superior in vitro activity compared to A/C against A. baumannii, although, theoretically, both should have similar activities. The therapeutic superiority of A/S over A/C needs to be studied, or else the breakpoints for these agents in in vitro tests need to be redefined.
Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India 110029, USA.
A
A
Pandey
A
A
Kapil
S
S
Sood
V
V
Goel
B
B
Das
P
P
Seth
D000150:Acinetobacter / Q000187:drug effects* / Q000302:isolation & purification; D000151:Acinetobacter Infections / Q000188:drug therapy / Q000382:microbiology; D000658:Amoxicillin / Q000008:administration & dosage; D000667:Ampicillin / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D019818:Clavulanic Acid / Q000008:administration & dosage; D004359:Drug Therapy, Combination / Q000008:administration & dosage*; D006801:Humans; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000008:administration & dosage*; D013407:Sulbactam / Q000008:administration & dosage; D018440:beta-Lactam Resistance
D000900:Anti-Bacterial Agents; D010406:Penicillins; D019818:Clavulanic Acid; D000667:Ampicillin; D000658:Amoxicillin; D013407:Sulbactam