Pain in central and peripheral demyelinating disorders.
Moderate to severe pain is a common feature of central and peripheral demyelinating disorders. Pain in multiple sclerosis tends to occur when the disease is well-established and usually lingers infinitely. Pain in Guillain-Barré syndrome tends to be particularly severe at the time of initial presentation and usually resolves over 8 to 12 weeks. Pain in both conditions is generally caused by either the direct effects of nerve injury or the result of paralysis and prolonged immobilization. Pain syndromes are well-defined in each disorder based on the underlying pathophysiology. Treatment involves a variety of pharmacologic and nonpharmacologic approaches individualized for each specific pain syndrome.
Associate Professor, Department of Clinical Neurological Sciences, University of Western Ontario, London, Ontario, Canada.
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Moulin
D000700:Analgesics / Q000627:therapeutic use; D020918:Complex Regional Pain Syndromes / Q000209:etiology* / Q000628:therapy; D020275:Guillain-Barre Syndrome / Q000175:diagnosis*; D006801:Humans; D009103:Multiple Sclerosis / Q000175:diagnosis*; D009437:Neuralgia / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D010147:Pain Measurement
D000700:Analgesics