Effect of antilymphocyte serum on bacterial translocation in mice.
Following intraperitoneally applied treatment with antilymphocyte serum (ALS) of immunosuppressive effect no bacterial translocation (BT) was observed in mice. The ALS treatment applied in combination with other immunosuppressive agents such as lymphotropic cytostatics as dianhydrogalactitol or chlorpromazine did not increase the mice's drug sensitivity to the used agents. According to our results, ALS can be suitable for combined application with other immunosuppressive agents as it can increase immunosuppression without side-effects such as those induced by bacterial translocation.
Institute of Microbiology, Semmelweis University of Medicine, Budapest, Hungary.
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Anderlik
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Antmann
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Bános
D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology*; D018988:Bacterial Translocation / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology; D003961:Dianhydrogalactitol / Q000494:pharmacology; D005260:Female; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008099:Liver / Q000382:microbiology; D008198:Lymph Nodes / Q000382:microbiology; D018655:Lymphocyte Count; D008297:Male; D051379:Mice; D013154:Spleen / Q000382:microbiology
D000961:Antilymphocyte Serum; D007166:Immunosuppressive Agents; D003961:Dianhydrogalactitol; D002746:Chlorpromazine