[Major psychiatric side effects of interferon alpha-2b].
The Netherlands Pharmacovigilance Foundation Lareb and the Drug Safety Unit of the Inspectorate for Health Care in 1997 received 6 reports of serious psychiatric symptoms during the use of interferon alpha-2b. Of these patients, three men aged 42, 49 and 62 years and three women aged 31, 40 and 33 years, two had had psychic symptoms before. Depression or psychosis developed 12-24 weeks after the start of the use of interferon alpha-2b with 3-10 million IU per week subcutaneously because of chronic hepatitis B or C. After cessation of the medication, four patients recovered after a few days or weeks; the course of one patient was unknown, one patient had committed suicide. Knowledge of these psychiatric adverse drug reactions to interferon alpha-2b can contribute to early recognition by the physician and timely treatment of the symptoms.
Stichting Landelijke Registratie en Evaluatie Bijwerkingen (LAREB). MH's-Hertogenbosch.
M
M
Heeringa
P
P
Honkoop
R A
RA
de Man
J
J
Feenstra
C M
CM
Smits
D000328:Adult; D003863:Depression / Q000139:chemically induced; D005260:Female; D006509:Hepatitis B / Q000188:drug therapy; D006526:Hepatitis C / Q000188:drug therapy; D006801:Humans; D007279:Injections, Subcutaneous; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000009:adverse effects*; D008297:Male; D001523:Mental Disorders / Q000139:chemically induced*; D008875:Middle Aged; D011605:Psychoses, Substance-Induced / Q000209:etiology; D011994:Recombinant Proteins
D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins
Ernstige psychiatrische bijwerkingen van interferon alfa-2b.