[Natural antihistone antibodies: their possible role in genesis of radiation injuries].
The substantial decrease of free natural antibodies reacting with histones under effect of 4 Gy total dose radiation in sera of healthy animals was established. It is supposed that the binding of natural antihistone antibodies with histones reduces the cytotoxic reactivity of histones released from cells under effect of ionizing radiation. It was determined that complexes of antihistone antibodies and histones get the ability to react with DNA. The possible biological role of these complexes is discussed.
Medical Radiological Research Center, Russian Academy of Medical Sciences, Obninsk.
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Abakushin
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AM
Poverennyĭ
D000818:Animals; D000974:Antibodies, Antinuclear / Q000097:blood*; D001323:Autoantibodies / Q000276:immunology*; D004268:DNA-Binding Proteins / Q000276:immunology; D005260:Female; D006657:Histones / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000276:immunology*; D014916:Whole-Body Irradiation
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D004268:DNA-Binding Proteins; D006657:Histones
Prirodnye antigistonovye antitela: veroiatnaia rol' v geneze luchevykh porazheniĭ.