Comparative efficacies of a calcium antagonist and an alpha1 blocker in elderly hypertensive patients with stroke.
We compared the effects of nilvadipine, a calcium antagonist, and terazosin. an alpha1 blocker, on the hemodynamics and quality of life (QOL) in 12 elderly hypertensive patients with stroke. Following a washout period of 2 weeks. nilvadipine or terazosin was administered for 2 weeks in a randomized crossover manner. At the end of control and treatment periods, we measured the 24-hour-ambulatory blood pressure (BP) and postural change of BP, and interviewed QOL. Terazosin treatment did not show consistent decrease of casual BP, but was associated with a transient decrease of systolic BP and an increase of pulse rate after standing, and enhanced postprandial decrease in BP. Nilvadipine decreased casual BP in a dose-dependent manner, but showed neither postural nor postprandial change of BP. There was no difference in QOL scores with either treatment. Results suggest that nilvadipine is preferable to terazosin for the treatment of elderly hypertensive patients with stroke.
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
M
M
Setoguchi
U
U
Onaka
I
I
Abe
Y
Y
Hasuo
Y
Y
Nishino
M
M
Fujishima
D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use*; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002561:Cerebrovascular Disorders / Q000188:drug therapy* / Q000209:etiology* / Q000503:physiopathology; D002940:Circadian Rhythm / Q000502:physiology; D018592:Cross-Over Studies; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000503:physiopathology; D008297:Male; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011224:Prazosin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011788:Quality of Life
D000317:Adrenergic alpha-Antagonists; D002121:Calcium Channel Blockers; C035100:nilvadipine; C041226:Terazosin; D009543:Nifedipine; D011224:Prazosin