An endogenous retrovirus with nucleic acid sequences similar to those of the multiple sclerosis associated retrovirus at the human T-cell receptor alpha, delta gene locus.
Retroviruses are suspected to be involved in the pathogenesis of autoimmune diseases, such as multiple sclerosis (MS). Here, we describe a complete cartography of a novel human endogenous retroviral sequence with a pol domain which shares a high homology with the pol sequence of the multiple sclerosis associated retrovirus (MSRV). Since this new endogenous retroviral sequence is located in the close vicinity of the locus of the human gene coding for the T-cell receptor (TcR) alpha and delta chains on chromosome 14, it could be of potential interest for the understanding of MS pathogenesis.
Neurobiologie du Développement Normal et Pathologique, INSERM, IFM, Paris, France.
P M
PM
Alliel
J P
JP
Périn
R
R
Pierig
F
F
Rieger
D000595:Amino Acid Sequence; D001483:Base Sequence; D016208:Databases, Factual; D015683:Gene Products, gag; D015684:Gene Products, pol; D006801:Humans; D008969:Molecular Sequence Data; D009103:Multiple Sclerosis / Q000821:virology*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics*; D012190:Retroviridae / Q000235:genetics*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid
D015683:Gene Products, gag; D015684:Gene Products, pol; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta