A role for genetic predisposition in subglottic stenosis.
We present the development of ASGS in two of three premature male triplets; the affected infants were monozygotic, while the unaffected triplet was dizygotic. All three shared remarkably similar risk factor profiles. There is suggested the existence of a genetic factor or factors which may predispose certain infants to the development of ASGS. The expression of such genetic influence may be expressed through the a priori presence of CSGS or other genetically based mechanisms including abnormal cartilage growth or development, specific patterns of chondral or mucosal injury, the action of specific growth factors, or the effects of autoimmune or inflammatory mediators. We propose that genetic predisposition be considered a possible risk factor in the development of subglottic stenosis.
Department of Otolaryngology, Children's Hospital of Buffalo, NY 14221-2006, USA.
M
M
Pizzuto
D
D
Donaldson
L
L
Brodsky
D020022:Genetic Predisposition to Disease; D006801:Humans; D007223:Infant; D007829:Laryngostenosis / Q000235:genetics* / Q000601:surgery; D008297:Male; D012307:Risk Factors; D014310:Triplets / Q000235:genetics*