Stimulation of the neostriatum induces jaw-opener muscle activity, but not jaw-closer muscle activity: an electromyographic study in the rat.
Microstimulation was carried out at 36 sites in the dorsal striatum in lightly anesthetized rats. Only at two sites, microstimulation of 40 microA induced a considerable EMG activity in the jaw-opener (anterior digastric muscle). No activity was evoked in the jaw-closers (masseter and temporalis muscles). The effective sites were confirmed to be localized in a small central region of the striatum at a level corresponding to the caudal end of the anterior commissure. The effect was ascribed to excitation of a small cluster of striatal neurons, rather than to antidromic activation of cerebral cortical neurons through their axons within the striatum. (1) The effect was abolished after destruction of neurons in the striatal region by injecting kainic acid. (2) The effect was not influenced by ablation of the neocortex. (3) Microinjection of kainic acid into the striatal region also induced the similar muscle activity in the jaw-opener, but not in the jaw-closers.
Department of Oral Neuroscience, Kyushu Dental College, Kitakyushu, Japan.
M
M
Hashimoto
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N
Amano
D000818:Animals; D001931:Brain Mapping; D004558:Electric Stimulation; D004576:Electromyography / Q000379:methods; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D007568:Jaw / Q000502:physiology*; D007608:Kainic Acid / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D008406:Masseter Muscle / Q000502:physiology; D008410:Masticatory Muscles / Q000502:physiology*; D008839:Microelectrodes; D008845:Microinjections; D009334:Neck Muscles / Q000502:physiology; D017072:Neostriatum / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013238:Stereotaxic Techniques; D013703:Temporal Muscle / Q000502:physiology
D007608:Kainic Acid