[Evidence of new diagnostic and prognostic human astrocytoma tumor markers. Potential therapeutic applications. II].
Human astrocytic tumors grow into the normal brain parenchyma either as localized tumors, or as highly diffuse neoplasms. The diffuse phenotype relates to a specific sub-type of neoplastic astrocytes with a high motility and invasion capacity. Motility features refer to locomotion while invasion features refer to protease secretion. Our data reveal that several peptides belonging to the gastrin/cholecystokinin peptide class are able to significantly (and in certain cases very significantly) modify the level of tumor growth (at the level of cell proliferation and/or cell death), of motility and of invasion in various experimental models of human astrocytic tumors. We are synthesizing various gastrin/cholecystokinin-related peptides in order to develop clinical applications with which we want to inhibit astrocytic tumor growth, individual neoplastic astrocytic motility and the invasion of the normal brain parenchyma.
Kiss
R
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Laboratoire d'Histologie, faculté de Médecine, U.L.B., Bruxelles.
D000818:Animals; D001254:Astrocytoma / Q000628:therapy*; D014408:Biomarkers, Tumor / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000628:therapy*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005755:Gastrins / Q000627:therapeutic use*; D006801:Humans; D051379:Mice; D012844:Sincalide / Q000627:therapeutic use*
D014408:Biomarkers, Tumor; D005755:Gastrins; C013550:gastrin 17; D012844:Sincalide
Mise en évidence de nouveaux marqueurs diagnostiques and pronostiques des tumeurs astrocytaires humaines. Applications thérapeutiques potentielles. II.