A randomized comparison of the methods of sperm preparation for intrauterine insemination.
OBJECTIVE
To compare the effectiveness of three methods of sperm preparation for IUI during superovulation of infertile women.


METHODS
Randomized assignment of one of three sperm preparation methods.


METHODS
University infertility practice.


METHODS
Infertile couples undergoing superovulation and IUI.


METHODS
The method of preparation of sperm for IUI during superovulation was assigned randomly to double centrifugation, multiple-tube swim-up, or Percoll density gradient.


METHODS
Total number and percent recovery of motile sperm, percent of recovered sperm with normal morphology, and cycle fecundity.


RESULTS
No method of sperm preparation provided better cycle fecundity than the others despite differences in sperm recovery.


CONCLUSIONS
Double centrifugation, multiple-tube swim-up, and Percoll density gradient sperm preparation for IUI yield similar cycle fecundity rates.
Division of Obstetrics and Gynecology, University Hospital, Penn State Geisinger Health System, Hershey, Pennsylvania, USA.
W C
WC
Dodson
J
J
Moessner
J
J
Miller
R S
RS
Legro
C L
CL
Gnatuk
D002498:Centrifugation / Q000379:methods; D003102:Colloids; D005260:Female; D006801:Humans; D007315:Insemination, Artificial / Q000379:methods*; D008297:Male; D011205:Povidone; D012822:Silicon Dioxide; D013048:Specimen Handling / Q000379:methods*; D013094:Spermatozoa; D013480:Superovulation
D003102:Colloids; C016039:Percoll; D012822:Silicon Dioxide; D011205:Povidone