Organisation and informational content of the Theileria parva genome.
When compared with other Apicomplexan organisms, Theileria parva has an exceptionally small, 10-12 Mbp, genome. There are only 4 chromosomes, each in the Mbp range, and a complete physical map, based on SfiI linking data, is available for each one. A number of genes and cDNAs have been mapped to specific SfiI fragments. Telomeres consist of the simple repeat sequence typical of chromosomal ends but sub-telomeric homologies do not extend beyond 5 kbp. The only dispersed repetitive sequences identified to date are minisatellites, but these are found on a subset of SfiI fragments. There are clusters of distinct multicopy sequences which contain ORFs. However, the majority of parasite protein coding genes are present in a single copy. They have a compact structure, exhibit a bias in codon usage and non-translated regions are small. Introns, if present, are unusually short. Overall, the genome contains remarkably little repetitive, non-coding DNA. The parasite mitochondrial DNA is linear in structure, has a limited protein coding capacity and fragmented rRNA genes and its telomeres contain inverted repeat sequences.
Nene
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International Livestock Research Institute, Nairobi, Kenya. V.NENE@CGNET.COM
Morzaria
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Bishop
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D000818:Animals; D002417:Cattle; D018503:Genome, Protozoan; D020161:Physical Chromosome Mapping; D016797:Theileria parva / Q000235:genetics*; D013801:Theileriasis / Q000469:parasitology*