[Antitoxic features of magnesium oxide under combined radiation and thermal injury].
Male Wistar rats were exposed to 7.5 Gy total body gamma radiation followed to the additional full-thickness thermal bum. It was shown, that single administration of magnesium oxide in 1 hour after combined injury significantly corrected the early signs of endogenous intoxication. The level of bacterial endotoxemia decreased as well as serum concentration of toxic oligopeptides; general blood serum toxicity has been reduced too. Four-fold magnesium oxide's using as an enterosorbent in combination with antibiotics (doxycyclini, gentamicini or ciprofloxacin) has ensured 73-100% rats survival. All untreated animals dead within 30 days after combined injury.
Nesterenko
V S
VS
Medical Radiological Research Center of Russian Academy Medical Sciences, Obninsk.
Budagov
R S
RS
Iatsenko
E M
EM
Makarov
G F
GF
Chureeva
L N
LN
D000818:Animals; D000863:Antacids / Q000008:administration & dosage*; D000900:Anti-Bacterial Agents; D004359:Drug Therapy, Combination / Q000008:administration & dosage*; D018882:Heat Stress Disorders; D008277:Magnesium Oxide / Q000008:administration & dosage*; D008297:Male; D011833:Radiation Injuries, Experimental / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar; D012774:Shock, Traumatic / Q000188:drug therapy
D000863:Antacids; D000900:Anti-Bacterial Agents; D008277:Magnesium Oxide
Antitoksichnye svoĭstva okisi magniia pri kombinirovannom radiatsionno-termicheskom porazhenii.