[Endogenous retroviral sequences analogous to that of the new retrovirus MSRV associated with multiple sclerosis (part 1)].
Multiple sclerosis (MS) is still of unknown origin and may involve autoimmune, genetic and viral components in a pathogenic sequence whose relative importance is yet to be determined. A peptide, isolated from the cerebrospinal fluid of MS patients, is similar to a fragment of the pol protein reverse transcriptase (RT) of the newly reported MSRV retrovirus. The 700 amino acid sequence of MSRV-RT is closely related to a novel human retroviral-like sequences. We also identified a gag-like sequence upstream of this human genomic RT-like sequence, which allowed us to identify altogether 4,000 nucleotides, possibly coding for an endogenous retroviruses. Homologous sequences found in other locations in the human genome seem to characterize a new family of retroviral endogenous sequences, which may be of relevance to multiple sclerosis.
Alliel
P M
PM
Neurobiologie du développement normal et pathologique, IFM, Paris, France.
Périn
J P
JP
Belliveau
J
J
Pierig
R
R
Nussbaum
J L
JL
Rieger
F
F
D000595:Amino Acid Sequence; D020077:Endogenous Retroviruses / Q000235:genetics*; D015894:Genome, Human; D006801:Humans; D008969:Molecular Sequence Data; D009103:Multiple Sclerosis / Q000235:genetics*; D012194:RNA-Directed DNA Polymerase / Q000235:genetics; D016914:Ribonuclease H / Q000235:genetics; D017386:Sequence Homology, Amino Acid
D012194:RNA-Directed DNA Polymerase; D016914:Ribonuclease H
Séquences rétrovirales endogènes analogues à celle du nouveau rétrovirus MSRV associé à la sclérose en plaques (1re partie).