Food allergy with monovalent sensitivity to poultry meat.
BACKGROUND
Allergy to poultry meat is only rarely covered in science. The few reports are usually related to patients allergic to eggs or bird feathers.


OBJECTIVE
Two patients with a clear history of monovalent, ingestive allergy to chicken and turkey meat, without other food allergies, were analysed. The relevant allergens were to be identified by immunoblotting.


METHODS
Both patients were evaluated with skin tests and specific IgE determination (CAP). Allergens were identified by SDS-PAGE and immunoblotting. Cross-reactivity of chicken and turkey meat was examined by IgE inhibition experiments.


RESULTS
Skin tests and specific IgE were positive for chicken and turkey in both patients. Cross-reactivities to other poultry meats were documented for duck and goose meat. No sensitization to egg components or poultry feathers could be found. Allergenic proteins of poultry meat were detected at molecular weights of 21, 23 and 50 kDa (distinct bands) and 13, 27 and 33kDa (faint bands). An additional band at 91 kDa for turkey, can probably not be considered a distinct allergenic epitope. Immunoblot inhibition confirmed cross-reactivity of chicken and turkey meat allergens.


CONCLUSIONS
Food allergy to poultry meat is a distinct disorder with crossreactivity among chicken, turkey and other poultries. The relevant allergens were identified by immunoblotting. Associated food allergy to egg-components is unlikely as the patients were able to tolerate egg and eggs products.
Department of Dermatology, University Hospital, Zurich, Switzerland.
Y D
YD
Cahen
R
R
Fritsch
B
B
Wüthrich
D000328:Adult; D000485:Allergens / Q000009:adverse effects* / Q000276:immunology; D000818:Animals; D002645:Chickens; D002648:Child; D003429:Cross Reactions; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D005512:Food Hypersensitivity / Q000209:etiology* / Q000276:immunology; D006801:Humans; D015151:Immunoblotting; D007070:Immunoglobulin A / Q000032:analysis; D008297:Male; D008460:Meat / Q000009:adverse effects*; D008970:Molecular Weight; D012882:Skin Tests; D014422:Turkeys
D000485:Allergens; D007070:Immunoglobulin A