[The effect of surfactant therapy on the oxygen treatment of premature infants with HMD].
A retrospective study is carried out, including 61 premature newborns, admitted to the Intensive Care Unit of State Maternity Hospital from 1994 to 1996. The aim of the study is to establish the influence of surfactant therapy on the duration of oxygen therapy and on the incidence of BPD. Criteria for entry: birth weight below 1500 grams, gestational age up o 32 weeks, clinical signs and x-ray proof of RDS.


METHODS
major inborn malformations and IVH--grams i.v.. Newborns are divided in 3 groups: 27 babies treated with Curosurf, 10 babies treated with Exosurf and 24 babies who received no surfactant. Results show that surfactant treated babies spent shorter time on ventilator support and oxygen therapy as a whole, the difference having high statistic level of significance in the Curosurf group. Surfactant therapy leads to lowering the incidence of oxygen dependency at 36 weeks post conception, especially in Curosurf treated babies.
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Iarŭkova
D000704:Analysis of Variance; D001688:Biological Products; D003131:Combined Modality Therapy; D004338:Drug Combinations; D004341:Drug Evaluation; D005233:Fatty Alcohols / Q000627:therapeutic use; D005865:Gestational Age; D006801:Humans; D006819:Hyaline Membrane Disease / Q000628:therapy*; D007231:Infant, Newborn; D007234:Infant, Premature; D010102:Oxygen Inhalation Therapy; D010743:Phospholipids; D010767:Phosphorylcholine; D011092:Polyethylene Glycols / Q000627:therapeutic use; D011663:Pulmonary Surfactants / Q000627:therapeutic use; D012189:Retrospective Studies
D001688:Biological Products; D004338:Drug Combinations; D005233:Fatty Alcohols; D010743:Phospholipids; D011663:Pulmonary Surfactants; D010767:Phosphorylcholine; D011092:Polyethylene Glycols; C047049:dipalmitoylphosphatidylcholine, hexadecanol, tyloxapol drug combination; C068291:poractant alfa
Vliianie na sŭrfaktant terapiiata vŭrkhu kislorodolechenieto pri nedonoseni detsa s KhMB.