Discovery of a potent and selective alpha 1A antagonist. Utilization of a rapid screening method to obtain pharmacokinetic parameters.
Adkison
K K
KK
Glaxo Wellcome Research and Development, Research Triangle Park, North Carolina 27709, USA.
Halm
K A
KA
Shaffer
J E
JE
Drewry
D
D
Sinhababu
A K
AK
Berman
J
J
D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists / Q000032:analysis / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000818:Animals; D002853:Chromatography, Liquid; D006801:Humans; D013058:Mass Spectrometry; D013329:Structure-Activity Relationship
D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists