Costimulation of naive CD8(+) lymphocytes induces CD4 expression and allows human immunodeficiency virus type 1 infection.
Human immunodeficiency virus type 1 (HIV-1) infection requires cell surface expression of CD4. Costimulation of CD8(+)/CD4(-) T lymphocytes by anti-CD3 and anti-CD28 antibodies or by allogeneic dendritic cells induced expression of CD4 and rendered these CD8 cells susceptible to HIV-1 infection. Naive CD45RA+ cells responded with greater expression of CD4 than did CD45RO+ cells. CD8(+) lymphocytes derived from fetal or newborn sources exhibited a greater tendency to express CD4, consistent with their naive states. This mechanism of infection suggests HIV-induced perturbation of the CD8 arm of the immune response and could explain the generally rapid disease progression seen in HIV-infected children.
Division of Hematology-Oncology, Department of Medicine, UCLA School of Medicine, Los Angeles, California 90095, USA.
S G
SG
Kitchen
Y D
YD
Korin
M D
MD
Roth
A
A
Landay
J A
JA
Zack
D000328:Adult; D015704:CD4 Antigens / Q000378:metabolism*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002478:Cells, Cultured; D002648:Child; D005333:Fetus; D015658:HIV Infections / Q000209:etiology* / Q000276:immunology*; D015497:HIV-1 / Q000472:pathogenicity*; D006801:Humans; D066298:In Vitro Techniques; D007231:Infant, Newborn; D017493:Leukocyte Common Antigens / Q000378:metabolism; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D010641:Phenotype; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D015728:Receptors, HIV / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000276:immunology
D015704:CD4 Antigens; D015728:Receptors, HIV; D017493:Leukocyte Common Antigens; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1