Autoimmune progesterone dermatitis: treatment with oophorectomy.
Autoimmune progesterone dermatitis is a rare manifestation of hypersensitivity to endogenous hormones with polymorphic clinical manifestations. We report a 28-year-old woman with a 5-year history of mucocutaneous erythema multiforme occurring cyclically in the premenstrual period. Progesterone sensitivity was demonstrated by challenge test with medroxyprogesterone acetate. Treatments with oestrogens, tamoxifen and triptorelin had to be withdrawn because of intolerable adverse effects. Oophorectomy finally cured the disease.
Department of Dermatology, Hospital General Universitario Morales Meseguer, Av. Marqués de los Vélez, 30008 Murcia, Spain.
J M
JM
Ródenas
M T
MT
Herranz
J
J
Tercedor
D000328:Adult; D001327:Autoimmune Diseases / Q000473:pathology / Q000601:surgery*; D004892:Erythema Multiforme / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D010052:Ovariectomy; D011374:Progesterone / Q000276:immunology*
D011374:Progesterone