[Urinary tract infection and biological markers: C-reactive protein, interleukins and procalcitonin].
Serum C reactive protein (CRP) remains a good marker of the severity of urinary tract infections in children, despite false negative results. Serum IL-6 is not a better marker; urinary IL-6 might have a better prognostic value as it is higher in patients with renal lesions due to infection, but low values are found in some cases. Serum procalcitonin levels are correlated with the importance of renal scars at scintigraphy, with less than 10% of false negative results. Further studies are needed to confirm the sensitivity and sensibility of these markers, especially for procalcitonin.
Gendrel
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Hôpital Saint-Vincent-de-Paul, Paris, France.
D015415:Biomarkers / Q000652:urine*; D002097:C-Reactive Protein / Q000652:urine*; D002116:Calcitonin / Q000652:urine*; D015740:Calcitonin Gene-Related Peptide; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D015850:Interleukin-6 / Q000652:urine*; D008297:Male; D011237:Predictive Value of Tests; D011498:Protein Precursors / Q000652:urine*; D012016:Reference Values; D014552:Urinary Tract Infections / Q000175:diagnosis* / Q000652:urine
D015415:Biomarkers; C000606589:CALCA protein, human; D015850:Interleukin-6; D011498:Protein Precursors; D002116:Calcitonin; D002097:C-Reactive Protein; D015740:Calcitonin Gene-Related Peptide
Infection urinaire et marqueurs biologiques: protéine C réactive, interleukines et procalcitonine.