Synthesis of prodrugs as bridged nucleosides.
Methods for the preparation of N,N'-connected bisnucleosides have been developed. The bridge is formally a carbonate ester of N-hydroxymethyl nucleosides. Both symmetrical and non-symmetrical bridged bisnucleosides are available.
Department of Pharmacy, University of Oslo, Norway.
J
J
Hatlelid
T
T
Benneche
K
K
Undheim
D009705:Nucleosides / Q000138:chemical synthesis*; D011355:Prodrugs / Q000138:chemical synthesis*
D009705:Nucleosides; D011355:Prodrugs