Regulation of the cholinergic gene locus.
DNase I hypersensitive site mapping of the human cholinergic gene locus has been used to detect cholinergic specific potential regulatory sites. Analysis of mutant PC12 cell lines provides evidence that protein kinase A II is required and coordinately regulates basal expression of both the ChAT and VAChT genes.
Department of Biochemistry, University of Kentucky, Lexington 40536-0084, USA.
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D000230:Adenocarcinoma; D000818:Animals; D001943:Breast Neoplasms; D002352:Carrier Proteins / Q000096:biosynthesis / Q000235:genetics*; D002795:Choline O-Acetyltransferase / Q000096:biosynthesis / Q000235:genetics*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D005260:Female; D005786:Gene Expression Regulation; D006367:HeLa Cells; D006801:Humans; D026901:Membrane Transport Proteins; D009447:Neuroblastoma; D016716:PC12 Cells; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D014158:Transcription, Genetic; D014407:Tumor Cells, Cultured; D050494:Vesicular Acetylcholine Transport Proteins; D033921:Vesicular Transport Proteins
D002352:Carrier Proteins; D026901:Membrane Transport Proteins; D012333:RNA, Messenger; C493459:SLC18A3 protein, human; C493461:Slc18a3 protein, rat; D050494:Vesicular Acetylcholine Transport Proteins; D033921:Vesicular Transport Proteins; D002795:Choline O-Acetyltransferase; D017868:Cyclic AMP-Dependent Protein Kinases