Gynandroblastoma in pregnancy: case report and review of literature.
Gynandroblastoma is an extremely rare tumor, composed of sex cord and stromal cells of both ovarian (granulosa-theca) and testicular (Sertoli-Leydig) types. We believe that its occurrence during pregnancy has not been previously reported. The patient was a 32-year-old woman who during her pregnancy was noted to have a progressively enlarging, unilocular left ovarian cyst. Beginning at 18 weeks gestation, the fetus required multiple platelet transfusions for severe alloimmune thrombocytopenia. A viable baby girl was delivered by cesarean section at 39 weeks gestation. At that time, an ovarian cystectomy also was performed. When the histology of the tissue subsequently became known, a left salpingo-oophorectomy was performed for gynandroblastoma. One year later, at the time of laparoscopic sterilization, the examination of the pelvis was normal.
Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA.
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D000328:Adult; D005260:Female; D006801:Humans; D018309:Neoplasms, Gonadal Tissue / Q000150:complications / Q000473:pathology / Q000601:surgery; D010048:Ovarian Cysts / Q000150:complications / Q000473:pathology / Q000601:surgery; D010051:Ovarian Neoplasms / Q000150:complications / Q000473:pathology / Q000601:surgery; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology / Q000601:surgery; D011262:Pregnancy Trimester, Second