[The persistent negative potential provoked in different structures of the rat brain by a single wave of spreading cortical depression].
The persistent negative potential (PNP) developed after a single wave of cortical spreading depression (SD) in the cortex, hippocampus, thalamus, and caudate nucleus. The PNP lasted for about 3-4 hours, its amplitude was 6-7 mV in the ipsilateral and 3-4 mV in the contralateral structures. After development of bilateral primary cortical SD waves the amplitudes of the respective PNP were summed up and reached 9-11 mV. However, after the repeated waves of cortical SD produced with 15-30-min intervals, the PNP level remained unchanged. We think that the PNP is an electrographic manifestation of the well known persistent vasoconstriction after a single wave of cortical SD. It seems to be related with reticular activation due to functional decortication.
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
V I
VI
Koroleva
L V
LV
Vinogradova
O S
OS
Korolev
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D013181:Cortical Spreading Depression / Q000187:drug effects / Q000502:physiology*; D004292:Dominance, Cerebral / Q000187:drug effects / Q000502:physiology; D004567:Electrodes, Implanted; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D018756:GABA Antagonists / Q000494:pharmacology; D010433:Pentylenetetrazole / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D018756:GABA Antagonists; D010433:Pentylenetetrazole
Ustoĭchivyĭ negativnyĭ potentsial, provotsiruemyĭ v razlichnykh strukturakh golovnogo mozga krysy odinochnoĭ korkovoĭ volnoĭ rasprostraniaiushcheĭsia depressii.