Effect of vaccination and the immunomodulators "bacillus of Calmette-Guérin, avridine and Propionibacterium acnes" on rabies in mice.
Responses of vaccination and treatment to immunomodulators against rabies in mice were evaluated through macrophage inhibition factor (MIF), intra-pad inoculation (IPI) and serum neutralization (SN) tests and by the detection of gamma-interferon (IFN-gamma). Onco-BCG, Avridine and Propionibacterium acnes were administered to groups of mice. Higher survival rates were found in animals treated with P. acnes. Lower levels of IFN-gamma were observed in the groups of infected and vaccinated mice. The IPI was not effective on detecting the response of delayed-type hypersensitivity. Vaccine induced in the infected animals a more intense response to MIF reaction.
Megid
J
J
Department of Veterinary Hygiene and Public Health, FMVZ-UNESP, Botucatu-SP, Brazil. megid@laser.com.br
Peraçolli
M T
MT
Curi
P R
PR
Zanetti
C R
CR
Cabrera
W H
WH
Vassao
R
R
Ito
F H
FH
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D001500:BCG Vaccine / Q000008:administration & dosage* / Q000276:immunology; D003959:Diamines / Q000008:administration & dosage* / Q000276:immunology; D005260:Female; D007371:Interferon-gamma / Q000378:metabolism; D008263:Macrophage Migration-Inhibitory Factors / Q000378:metabolism; D051379:Mice; D009500:Neutralization Tests; D011425:Propionibacterium acnes / Q000276:immunology*; D011818:Rabies / Q000276:immunology / Q000517:prevention & control*; D011819:Rabies Vaccines / Q000008:administration & dosage / Q000276:immunology; D014611:Vaccination
D000276:Adjuvants, Immunologic; D001500:BCG Vaccine; D003959:Diamines; D008263:Macrophage Migration-Inhibitory Factors; D011819:Rabies Vaccines; D007371:Interferon-gamma; C006270:avridine