[Graft function following renal transplantation in children].
BACKGROUND
Since renal transplantation is known to be the best choice for the growing child with end-stage renal failure, we prospectively evaluated early and late graft function in transplanted children.


METHODS
The study included 78 children (32 girls, 46 boys) 10.4 +/- 0.6 years at the time of transplantation. Renal investigations were performed at 3, 6 and 12 months post-transplantation and yearly thereafter. Inulin clearance was used to evaluate the glomerular filtration rate (GFR), and the reabsorption rates of Na, P and Ca were measured concomitantly.


RESULTS
The overall adjusted GFR was approximately 70 mL/min/1.73 m2 and remained unchanged during the first 5 years post-transplantation. In the mean time the absolute GFR increased significantly, suggesting a remaining capacity for compensatory hypertrophy of the transplanted kidney. Renal function was significantly influenced by the number of rejection episodes during the first 2 years post-transplantation but no correlation was found between GFR and the number of HLA mismatches or the use of preemptive transplantation.
Unité de néphrologie pédiatrique, Université Claude-Bernard et hôpital Edouard-Herriot, Lyon, France.
L
L
Dubourg
A
A
Hadj-Aïssa
M
M
Dawahra
B
B
Parchoux
X
X
Martin
L
L
David
N
N
Pozet
D
D
Long
P
P
Cochat
D002648:Child; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000502:physiology; D008297:Male; D011446:Prospective Studies; D016896:Treatment Outcome
Evolution de la fonction du greffon après transplantation rénale chez l'enfant.