Pharmacokinetics of deflazacort in renal transplanted and hemodialyzed children.
Deflazacort (DFZ) pharmacokinetics was evaluated in fifteen pediatric patients on chronic hemodialysis or after renal transplantation, and in three normal children. After overnight fasting, oral DFZ 0.26+/-0.01 mg/kg (mean +/- SEM) was given. Serial blood samples were collected for 360 min and analyzed by HPLC for 21-hydroxy-DFZ (21-HO-DFZ). Serum concentration profiles and pharmacokinetic parameters were similar in patients on hemodialysis, renal transplant recipients and normal children. Elimination half-life was longer in the 9 cyclosporine-treated subjects (108.0+/-13.6 min) than in the other nine (71.2+/-8.3 min; p <0.02). Our finding suggests that, from a pharmacokinetic point of view, DFZ dose adjustment for renal function is not necessary in children with chronic renal failure or after renal transplantation.
Ferraris
J
J
Servicio de Nefrología Pediátrica, Hospital Italiano, Buenos Aires, Argentina.
Krmar
R
R
Flores
D
D
Giogieri
S
S
Díaz
L
L
Tessler
J
J
D000293:Adolescent; D001379:Azathioprine / Q000627:therapeutic use; D002648:Child; D016572:Cyclosporine / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006207:Half-Life; D006801:Humans; D007166:Immunosuppressive Agents / Q000097:blood / Q000493:pharmacokinetics*; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D016030:Kidney Transplantation / Q000502:physiology* / Q000706:statistics & numerical data; D008297:Male; D011282:Pregnenediones / Q000097:blood / Q000493:pharmacokinetics*; D006435:Renal Dialysis / Q000706:statistics & numerical data; D018709:Statistics, Nonparametric; D013997:Time Factors
D007166:Immunosuppressive Agents; D011282:Pregnenediones; D016572:Cyclosporine; C021988:deflazacort; D001379:Azathioprine