Age-related changes of the 3'APOB-VNTR genotype pool in ageing cohorts.
The analysis of seven different age cohorts (697 individuals from 10 to 109 years old) revealed age-related changes in the 3'APOB-VNTR genotype pool. By recoding the 3'APOB-VNTR alleles into three size-classes (small, S, 26-34 repeats; medium, M, 35-39 repeats; large, L, 41-55 repeats), an age-related convex trajectory of the frequency of SS homozygotes was found. The frequency of SS in the genotype pool increased from the group aged 10-19 years (3.06 +/- 1.74%) to that aged 40-49 years (8.51 +/- 4.07%). Then it declined reaching the minimum value in centenarians (1.58 +/- 0.90%). The observed trajectory is in agreement with that expected by assuming crossing of mortality curves relevant to subgroups of individuals having different genotypes.
De Benedictis
G
G
Cell Biology Dept., University of Calabria, Italy. g.debenedictis@unical.it
Carotenuto
L
L
Carrieri
G
G
De Luca
M
M
Falcone
E
E
Rose
G
G
Yashin
A I
AI
Bonafè
M
M
Franceschi
C
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000483:Alleles; D001055:Apolipoproteins B / Q000235:genetics*; D002648:Child; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D004247:DNA / Q000032:analysis; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats / Q000235:genetics*; D016133:Polymerase Chain Reaction / Q000379:methods
D001055:Apolipoproteins B; D004247:DNA