Improvement of P300 latency by treatment in non-insulin-dependent diabetes mellitus.
P300 event-related potentials were investigated in 24 cases of non-insulin-dependent (Type II) diabetes mellitus (NIDDM) without apparent central nervous system (CNS) symptoms and without cerebrovascular diseases on head magnetic resonance imaging, and in 16 age-matched healthy control subjects. N200 and P300 latencies were significantly prolonged and N200 and P300 amplitudes were significantly smaller in the NIDDM group than in the healthy control group. P300 latency was significantly shorter after the treatment than before. N200 and P300 waves have been recognized as useful indicators of cognitive function. The present study suggests that cognitive function is impaired in NIDDM patients and may improve with treatment of hyperglycemia.
Department of Neurology, Nihon University School of Medicine, Tokyo, Japan.
Y
Y
Mochizuki
M
M
Oishi
Y
Y
Hayakawa
M
M
Matsuzaki
T
T
Takasu
D003071:Cognition / Q000502:physiology; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology* / Q000628:therapy*; D004569:Electroencephalography; D018913:Event-Related Potentials, P300; D006801:Humans; D008875:Middle Aged