Bone remodelling: a signalling system for osteoclast regulation.
Two physiological regulators of osteoclast maturation have recently been identified: the secreted protein osteoprotegerin and the cell-surface ligand to which it binds. These proteins are likely to play an important part in the control of bone resorption, but are also likely to have important roles in other tissues.
Filvaroff
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Department of Endocrinology, Genentech, South San Francisco, California 94080-4990, USA.
Derynck
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R
D000818:Animals; D015703:Antigens, CD / Q000502:physiology; D051017:Apoptosis Regulatory Proteins; D016723:Bone Remodeling / Q000502:physiology*; D002117:Calcitriol / Q000502:physiology; D002352:Carrier Proteins; D002454:Cell Differentiation; D017868:Cyclic AMP-Dependent Protein Kinases / Q000502:physiology; D050822:Cytokine Receptor gp130; D005786:Gene Expression Regulation; D006023:Glycoproteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D006801:Humans; D016173:Macrophage Colony-Stimulating Factor / Q000172:deficiency / Q000502:physiology / Q000627:therapeutic use; D008562:Membrane Glycoproteins / Q000235:genetics / Q000502:physiology; D051379:Mice; D008817:Mice, Mutant Strains; D016328:NF-kappa B / Q000502:physiology; D010006:Osteoblasts / Q000502:physiology; D010010:Osteoclasts / Q000502:physiology*; D010022:Osteopetrosis / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology; D053244:Osteoprotegerin; D010281:Parathyroid Hormone / Q000502:physiology; D053245:RANK Ligand; D053246:Receptor Activator of Nuclear Factor-kappa B; D018160:Receptors, Cytoplasmic and Nuclear; D011987:Receptors, Steroid / Q000502:physiology; D018124:Receptors, Tumor Necrosis Factor / Q000502:physiology; D015398:Signal Transduction; D053221:TNF-Related Apoptosis-Inducing Ligand; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D015703:Antigens, CD; D051017:Apoptosis Regulatory Proteins; D002352:Carrier Proteins; D006023:Glycoproteins; C494199:IL6ST protein, human; C494200:Il6st protein, mouse; D008562:Membrane Glycoproteins; D016328:NF-kappa B; D053244:Osteoprotegerin; D010281:Parathyroid Hormone; D053245:RANK Ligand; D053246:Receptor Activator of Nuclear Factor-kappa B; D018160:Receptors, Cytoplasmic and Nuclear; D011987:Receptors, Steroid; D018124:Receptors, Tumor Necrosis Factor; D053221:TNF-Related Apoptosis-Inducing Ligand; C505686:TNFRSF11A protein, human; C506030:TNFRSF11B protein, human; C505653:TNFSF10 protein, human; C505688:TNFSF11 protein, human; C505687:Tnfrsf11a protein, mouse; C506031:Tnfrsf11b protein, mouse; C505654:Tnfsf10 protein, mouse; C505689:Tnfsf11 protein, mouse; D014409:Tumor Necrosis Factor-alpha; D050822:Cytokine Receptor gp130; D016173:Macrophage Colony-Stimulating Factor; D017868:Cyclic AMP-Dependent Protein Kinases; D002117:Calcitriol