[Fatty acids metabolism of rat liver after extra-lethal gamma-irradiation].
The effect of acute gamma-irradiation of rats at super lethal doses from 25 to 270 Gy on the synthesis and amount of fatty acids, neutral lipids and phospholipids of liver was studied 48 h after gamma-irradiation. It was shown, that the synthesis of fatty acids, cholesterol, cholesterol ethers and phospholipids was activated 48 h after irradiation at 25-100 Gy, but the irradiation in the doses above 100 Gy inhibited the activation of lipid synthesis. The amount of fatty acids and neutral lipids of the rat liver decreased at 15-100 Gy. After irradiation at 200, 270 Gy the fatty acid content increased significantly, while the decrease of concentration of cholesterol ethers remained under the control level. This is assumed to be a result of the radioresistance to a some degree in the system of fatty acid synthesis of the rat liver to the gamma-irradiation in the super lethal doses.
Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino.
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Markevich
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005227:Fatty Acids / Q000378:metabolism*; D005720:Gamma Rays; D008099:Liver / Q000378:metabolism* / Q000528:radiation effects*; D008297:Male; D011833:Radiation Injuries, Experimental / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014916:Whole-Body Irradiation
D005227:Fatty Acids
Metabolizm zhirnykh kislot v pecheni krys pri deĭstvii gamma-radiatsiiv sverkhletal'nykh dozakh.