Risk factors for the early acquisition of human herpesvirus 6 and human herpesvirus 7 infections in children.
OBJECTIVE
Human herpesviruses 6 and 7 (HHV-6 and HHV-7) are common infections in children, but risk factors for their early acquisition have not been described.


METHODS
Excess sera from children 12 to 31 months of age enrolled in a cross-sectional, random survey were tested for human herpesviruses 6 and 7 infection, as measured by using immuno-blot and immunofluorescence assays.


RESULTS
Of 164 children 131 (80%) had antibody to HHV-6, and 79 (47%) of 167 had antibody to HHV-7. In logistic regression analysis low income [odds ratio (OR), 2.9; 95% confidence intervals (CI), 1.02 to 8.7] and having more than 1 sibling (OR=2.1, 95% CI=0.9 to 5.1) were risk factors for HHV-6 infection after adjusting for age, whereas month of test (OR=2.7, 95% CI=1.3 to 5.9) and Black race (OR=2.0, 95% CI=0.9, 4.6) were associated with a higher prevalence of HHV-7 infection. In contrast having ever been breast-fed appeared to protect against HHV-7 infection (OR=0.5, 95% CI=0.3 to 1.1).


CONCLUSIONS
Despite studies linking both HHV-6 and HHV-7 with exanthem subitum, risk factors for the early acquisition of HHV-6 and HHV-7 are distinct. Subsequent studies investigating the transmission of HHV-6 should explore family size and other factors associated with poverty, whereas breast-feeding should be examined as a protective factor for HHV-7 infection.
Children's Hospital Medical Center and the Department of Pediatrics, University of Cincinnati, OH 45229-3039, USA. bruce.lanphear@chmcc.org
B P
BP
Lanphear
C B
CB
Hall
J
J
Black
P
P
Auinger
D000914:Antibodies, Viral / Q000097:blood; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005077:Exanthema Subitum / Q000453:epidemiology; D005455:Fluorescent Antibody Technique; D006566:Herpesviridae Infections / Q000175:diagnosis / Q000453:epidemiology*; D015654:Herpesvirus 6, Human; D016199:Herpesvirus 7, Human; D006801:Humans; D015151:Immunoblotting; D007223:Infant; D016015:Logistic Models; D012307:Risk Factors; D012959:Socioeconomic Factors
D000914:Antibodies, Viral