NaCl-preferring NZB/B1NJ mice and NaCl-avoiding CBA/J mice have similar amiloride inhibition of chorda tympani responses to NaCl.
Integrated chorda tympani nerve responses to NaCl were studied in two mouse strains, an NaCl-preferring NZB/B1NJ and an NaCl-avoiding CBA/J. The NaCl responses of both strains had similar magnitude and were suppressed by amiloride to a similar extent. This suggests that peripheral gustatory responsiveness to NaCl is not the only mechanism underlying mouse strain variation in NaCl acceptance.
Monell Chemical Senses Center, Philadelphia, PA 19104-3308, USA.
Y
Y
Ninomiya
A A
AA
Bachmanov
A
A
Yatabe
G K
GK
Beauchamp
D000584:Amiloride / Q000494:pharmacology*; D000818:Animals; D002814:Chorda Tympani Nerve / Q000187:drug effects* / Q000502:physiology; D004232:Diuretics / Q000494:pharmacology*; D004347:Drug Interactions; D005518:Food Preferences; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008814:Mice, Inbred NZB; D012965:Sodium Chloride / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D013045:Species Specificity; D013649:Taste
D004232:Diuretics; D012965:Sodium Chloride; D000584:Amiloride