[Positron-emission tomography of the skeletal system using 18FNa: the incidence, pattern of the findings and distribution of benign changes].
OBJECTIVE
We evaluated the frequency, distribution and appearance of benign lesions in 18F-PET scans.


METHODS
Between March 1996 and May 1997, 18F-PET scans were performed in 59 patients in addition to conventional planar bone scintigraphy. Eleven patients were subjected to additional SPECT imaging. The main indication was searching for bone metastases (58 pat.). The diagnosis was confirmed radiologically.


RESULTS
With 18F-PET in 39 patients (66.1%) 152 benign lesions, mostly located in the spine were detected. 99mTc bone scans revealed 45 lesions in 10 patients. Osteoarthritis of the intervertebral articulations (69%) or of the acromioclavicular joint (15%) were the most common reasons for degenerative lesions detected with 18F-PET. Osteophytes appeared as hot lesions located at two adjacent vertebral endplates. Osteoarthritis of the intervertebral articulations showed an enhanced tracer uptake at these localizations, whereas endplate fractures of the vertebral bodies appeared very typical; solitary fractures of the ribs could not be differentiated from metastases. Rare benign lesions were not studied.


CONCLUSIONS
Most of the degenerative lesions (84%) detected with 18F-PET had a very typical appearance and could be detected with the improved spatial resolution and advantages of a tomographic technique. 18F-PET had an increased accuracy in detecting degenerative bone lesions.
Abteilung für Nuklearmedizin, Universität Ulm.
H
H
Schirrmeister
J
J
Kotzerke
M
M
Rentschler
H
H
Träger
S
S
Fenchel
K
K
Nüssle
C G
CG
Diederichs
S N
SN
Reske
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001847:Bone Diseases / Q000000981:diagnostic imaging*; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D005462:Fluorine Radioisotopes; D006801:Humans; D008875:Middle Aged; D019275:Radiopharmaceuticals; D012969:Sodium Fluoride; D013669:Technetium Tc 99m Medronate; D014055:Tomography, Emission-Computed / Q000295:instrumentation / Q000379:methods*; D014915:Whole-Body Counting / Q000295:instrumentation / Q000379:methods
D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D012969:Sodium Fluoride; D013669:Technetium Tc 99m Medronate
Die Positronenemissionstomographie des Skelettsystems mit 18FNa: Häufigkeit, Befundmuster und Verteilung benigner Veränderungen.