Odontogenic fibroma in Sprague-Dawley rats: a report of 2 cases.
Two cases of odontogenic fibroma occurring in aged Sprague-Dawley rats are described. Both neoplasms were associated with a maxillary incisor and had identical histomorphological features. They were composed of solid proliferations of primitive, dental pulp-like mesenchyme separated by areas of collagenization. Small strands and islands of mainly undifferentiated odontogenic epithelium immunostaining for keratins were scattered throughout both tumours. As a further characteristic, the lesions contained small foci of mineralization which were either cementum-like or resembled dysplastic dentin. The odontogenic fibroma represents a further type of odontogenic tumour in rats, which due to its typical histomorphology, can easily be differentiated from other odontogenic tumours such as ameloblastic odontoma or ameloblastoma.
Fraunhofer Institute of Toxicology and Aerosol Research, Hannover, Germany.
H
H
Ernst
G
G
Scampini
B
B
Durchfeld-Meyer
P
P
Brander-Weber
S
S
Rittinghausen
D000564:Ameloblastoma / Q000473:pathology; D000818:Animals; D003937:Diagnosis, Differential; D005260:Female; D005350:Fibroma / Q000473:pathology*; D007180:Incisor / Q000473:pathology; D009808:Odontogenic Tumors / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley