[The synthetic leu-enkephalin--dalargin--in the therapy of the irritable bowel syndrome and chronic noninfectious undefined colitis].
The author proceeds from the belief that it is the dystrophic changes and disturbances in the regeneration of the intestinal epithelium that play a decisive role in the pathogenesis and morphogenesis of irritable intestinal syndrome and chronic non-infectious undefined colitis. The above alterations develop secondary to the action of harmful factors and disturbed trophic influences of neurohumoral systems of regulation during different stages of stress. At the same time the synthetic leu-enkefalin dalargin is endowed with a marked antistressor activity as well as ability to strikingly improve the regeneration of the epithelium. This was reason why therapeutic efficacy of dalargin has been given a trial in the above pathologies. Positive dynamics of symptoms of the conditions in question has been shown as well as of the histologic picture of colonic mucosa biopsies during the course of treatment of the above ailments with dalargin.
Iu O
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Smishchuk
D001706:Biopsy; D002908:Chronic Disease; D003092:Colitis / Q000188:drug therapy* / Q000473:pathology; D003106:Colon / Q000473:pathology; D003109:Colonic Diseases, Functional / Q000188:drug therapy* / Q000473:pathology; D003248:Constipation / Q000188:drug therapy / Q000473:pathology; D004341:Drug Evaluation; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans
D005765:Gastrointestinal Agents; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Syntetychnyĭ leĭ-enkefalin--dalarhin u terapiï syndromu podraznenykh kyshok i khronichnoho neinfektsiĭnoho neitochnenoho kolitu.