Analysis of prenatal and gestational care given to women with epilepsy.
OBJECTIVE
To assess past care practices of neurologists and obstetricians to identify areas in which practice patterns differ from currently accepted optimal care.


METHODS
Retrospective chart review of 155 women identified as having a diagnosis of epilepsy (or seizure disorder) who had been pregnant any time between January 1988 and December 1995 and were admitted to Stanford University Hospital for delivery. A total of 161 pregnancies (132 women) were selected for study.


RESULTS
An obstetrician was seen at some point during the pregnancy in 99% of the pregnancies, whereas a neurologist was seen at least once in only 64% of the pregnancies. In the 3 months before conception, an obstetrician was seen in 5% of the pregnancies and a neurologist was seen in 15%. Seventy-five percent of the patients taking antiepileptic medication and 65% of the untreated patients had documentation of folate supplementation at any time during pregnancy. Vitamin K supplementation in the final month of pregnancy was documented for only 41% of those receiving antiepileptic drugs. In over one-third of the pregnancies the mother did not have a maternal serum alpha-fetoprotein measure documented and a similar percentage did not receive genetic counseling. Monitoring of the maternal serum concentration of the non-protein-bound fraction of the prescribed antiepileptic drugs was not documented.


CONCLUSIONS
We identified specific omissions of appropriate vitamin supplementation, genetic counseling, and drug level monitoring. Educational efforts should be targeted to improve the management of pregnancy in women with epilepsy.
Department of Neurology and Neurological Sciences and Stanford Comprehensive Epilepsy Center, CA, USA.
C G
CG
Seale
M J
MJ
Morrell
L
L
Nelson
M L
ML
Druzin
D000028:Abortion, Induced / Q000706:statistics & numerical data; D000022:Abortion, Spontaneous / Q000453:epidemiology*; D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D004829:Epilepsy, Generalized / Q000188:drug therapy*; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage; D006397:Hematinics / Q000008:administration & dosage; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D011295:Prenatal Care; D012189:Retrospective Studies; D012307:Risk Factors; D014812:Vitamin K / Q000008:administration & dosage
D000927:Anticonvulsants; D006397:Hematinics; D014812:Vitamin K; D005492:Folic Acid