In vitro activities of 15 antimicrobial agents against clinical isolates of South African enterococci.
The activities of a panel of currently available antibiotics and the investigational agents LY 333328, linezolid, CL 331,002, CL 329,998, moxifloxacin (BAY 12-8039), trovafloxacin, and quinupristin-dalfopristin against 274 clinical isolates of enterococci were determined. No vancomycin resistance or beta-lactamase production was observed. Except for 12 isolates (all non-Enterococcus faecalis) showing reduced susceptibility to quinupristin-dalfopristin (MIC, >/=4 microg/ml), the new agents exhibited promising in vitro antienterococcal activity.
Department of Medical Microbiology, University of the Orange Free State, Bloemfontein 9300, South Africa. GNMBDS@med.uovs.ac.za
M C
MC
Struwig
P L
PL
Botha
L J
LJ
Chalkley
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D016983:Enterococcus / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D013019:South Africa
D000900:Anti-Bacterial Agents