Treatment of photodamaged skin with topical tretinoin: an update.
The utility of topical tretinoin in combination with sun protection has now been formally established as a useful approach to the treatment of sun-damaged skin. The early observations of our group have been confirmed in numerous well controlled clinical trials. Moreover, a great deal is known about structural and even molecular changes induced by topical tretinoin, which account for the clinical benefits achieved by this agent. A great deal has been learned in a very short period of time, and these findings represent another major use of retinoid therapy in dermatologic disease.
University of Pennsylvania Health System, Philadelphia 19104-4283, USA.
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Leyden
D000287:Administration, Topical; D006801:Humans; D007641:Keratolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D018579:Patient Selection; D012871:Skin Diseases / Q000188:drug therapy*; D013472:Sunlight / Q000009:adverse effects*; D014212:Tretinoin / Q000008:administration & dosage / Q000627:therapeutic use*
D007641:Keratolytic Agents; D014212:Tretinoin