[Enterobacter aerogenes pneumopathy treated by a cefepime-sulbactam-gentamicin combination].
BACKGROUND
Enterobacter aerogenes is the fifth most frequent pathogen causing nosocomial infections. Several strains have developed multiple resistance by over-production of a natural cephalosporinase and by the presence of wide-spectrum betalactamases.


METHODS
A patient with chronic respiratory failure developed Enterobacter aerogenes pneumonia while under mechanical ventilation. The infection was successfully treated with a cefepime, sulbactam, gentamycin combination.


CONCLUSIONS
Choosing the optimum antibiotic therapy is a difficult task in many nosocomial infections. In certain cases, combining a betalactamase inhibitor with the appropriate antibiotic can improve bactericidal activity and provide successful cure.
Service de Réanimation polyvalente, CHG du Pays d'Aix, Aix-en-Provence.
P
P
Mardrus
J L
JL
Le Grand
H
H
Chardon
B
B
Garrigues
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000077723:Cefepime; D002511:Cephalosporins / Q000008:administration & dosage / Q000627:therapeutic use*; D002908:Chronic Disease; D003428:Cross Infection / Q000209:etiology; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D004359:Drug Therapy, Combination / Q000008:administration & dosage / Q000627:therapeutic use*; D004754:Enterobacter; D004756:Enterobacteriaceae Infections / Q000188:drug therapy*; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000188:drug therapy*; D012121:Respiration, Artificial / Q000009:adverse effects; D012131:Respiratory Insufficiency / Q000382:microbiology; D013407:Sulbactam / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D005839:Gentamicins; D000077723:Cefepime; D013407:Sulbactam
Pneumopathie à Enterobacter aerogenes traitée par l'association céfépime-sulbactam-gentamicine.