Physiology and healing dynamics of chronic cutaneous wounds.
In the last few decades, a great deal of progress has been made in understanding the cellular and biochemical interplay that comprises the normal wound healing response. This response is a complex process involving intricate interactions among a variety of different cell types, structural proteins, growth factors, and proteinases. The normal wound repair process consists of three phases--inflammation, proliferation, and remodeling--that occur in a predictable sequence and comprise a series of cellular and biochemical events. A review of the biochemical and physiologic processes that regulate wound healing and the cascade of cellular events that gives rise to the healing process is presented here.
Stadelmann
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WK
Division of Plastic and Reconstructive Surgery, University of Louisville, Kentucky 40292, USA.
Digenis
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AG
Tobin
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GR
D002908:Chronic Disease; D003094:Collagen / Q000096:biosynthesis; D017719:Diabetic Foot / Q000503:physiopathology*; D005347:Fibroblasts / Q000502:physiology; D006133:Growth Substances / Q000494:pharmacology; D006801:Humans; D007249:Inflammation; D012867:Skin / Q000293:injuries; D014945:Wound Healing / Q000502:physiology*
D006133:Growth Substances; D003094:Collagen