Interaction of C1q and the collectins with the potential receptors calreticulin (cC1qR/collectin receptor) and megalin.
Several proteins have been identified as candidate cell-surface receptors for the complement protein C1q. Some of these also interact with the structurally-related collectin proteins. Previous descriptions of C1q-binding properties of cells, and information on the cellular distribution of candidate receptors suggest that there is more than one physiologically relevant receptor for C1q. Two such candidate receptors, cell-surface calreticulin (also referred to as cC1qR or collectin receptor) and megalin are discussed in this review.
Department of Biochemistry, University of Oxford, UK. rbsim@bioch.ox.ac.uk
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Sim
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Moestrup
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Stuart
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Lynch
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Lu
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Schwaeble
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Malhotra
D000595:Amino Acid Sequence; D000818:Animals; D002135:Calcium-Binding Proteins / Q000302:isolation & purification / Q000378:metabolism*; D037282:Calreticulin; D002352:Carrier Proteins / Q000302:isolation & purification / Q000378:metabolism*; D002417:Cattle; D037222:Collectins; D015922:Complement C1q / Q000378:metabolism*; D019281:Dimerization; D004705:Endocytosis; D026541:Heymann Nephritis Antigenic Complex; D006801:Humans; D018960:Hyaluronan Receptors; D008562:Membrane Glycoproteins / Q000378:metabolism*; D024101:Mitochondrial Proteins; D008969:Molecular Sequence Data; D011951:Receptors, Complement / Q000302:isolation & purification / Q000378:metabolism*; D012261:Ribonucleoproteins / Q000302:isolation & purification / Q000378:metabolism*
C087299:C1QBP protein, human; D002135:Calcium-Binding Proteins; D037282:Calreticulin; D002352:Carrier Proteins; D037222:Collectins; D026541:Heymann Nephritis Antigenic Complex; D018960:Hyaluronan Receptors; D008562:Membrane Glycoproteins; D024101:Mitochondrial Proteins; D011951:Receptors, Complement; D012261:Ribonucleoproteins; C032402:complement 1q receptor; D015922:Complement C1q