Antibodies against Helicobacter pylori were detected in the cerebrospinal fluid obtained from patients with Guillain-Barré syndrome.
We examined the antibodies against Helicobacter pylori proteins in the cerebrospinal fluid (CSF) of 7 patients with Guillain-Barré syndrome (GBS). Crude H. pylori antigens, fractionated heat shock protein (HSP), and urease B (UB) from H. pylori antigens were separated by SDS-PAGE. With Western blot analysis, four of seven CSF samples had several IgG antibodies against H. pylori proteins, including HSP and UB. No cross reactivity against Campylobacter jejuni was observed. These antibodies may be involved in the immune responses of patients with GBS.
Department of Neurology, School of Medicine, Sapporo Medical University, Japan.
S
S
Chiba
T
T
Sugiyama
H
H
Matsumoto
K
K
Hisano
T
T
Awakawa
K
K
Hiura
M
M
Saitoh
K
K
Imai
D000328:Adult; D000907:Antibodies, Bacterial / Q000134:cerebrospinal fluid*; D015153:Blotting, Western; D005260:Female; D006360:Heat-Shock Proteins / Q000276:immunology; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D007527:Isoenzymes / Q000276:immunology; D008297:Male; D011129:Polyradiculoneuropathy / Q000134:cerebrospinal fluid* / Q000276:immunology*; D014510:Urease / Q000276:immunology
D000907:Antibodies, Bacterial; D006360:Heat-Shock Proteins; D007074:Immunoglobulin G; D007527:Isoenzymes; D014510:Urease