Protein targeting: getting into the groove.
The 54 kDa subunit of the signal recognition particle has to identify a diverse family of substrates and deliver them in a controlled manner to the translocation machinery of the endoplasmic reticulum. Important new insights into the function of this sorting protein have emerged from recent biochemical and structural studies.
Bernstein
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HD
Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health Building 10, Room 9D-20, 10 Center Drive, Bethesda, Maryland 20892-1810, USA. harris_bernstein@nih.gov
D000818:Animals; D008715:Methionine / Q000378:metabolism; D018271:Signal Recognition Particle / Q000378:metabolism*; D013379:Substrate Specificity
D018271:Signal Recognition Particle; D008715:Methionine