Use of mouth pressure twitches induced by cervical magnetic stimulation to assess voluntary activation of the diaphragm.
There is a need for a simple method to assess the adequacy of diaphragm activation during voluntary inspiratory efforts in patients with suspected respiratory muscle weakness. We have compared mouth (Pmo,t), oesophageal (Poes,t) and transdiaphragmatic (Pdi,t) twitch pressure elicited by cervical magnetic stimulation (CMS) in five normal men (mean (SD) age 32.2 (1.8) yrs) on two separate study days. Single magnetic stimuli were delivered at functional residual capacity during relaxation and during graded voluntary inspiratory efforts against a closed airway. As voluntary-effort transdiaphragmatic and oesophageal pressure increased, Pdi,t and Poes,t decreased linearly (r range, respectively, 0.82-0.98 and 0.87-0.95). During relaxation, Pmo,t was unreliable due to the poor transmission of intrathoracic pressure, but during inspiratory efforts, the relation between voluntary mouth pressure and Pmo,t was also linear (r range 0.84-0.95). On average, our subjects voluntarily generated 99, 100 and 102% of the maximum transdiaphragmatic, oesophageal and mouth pressures predicted by the respective linear regression equations. Pmo,t was correlated to both Poes,t and Pdi,t during inspiratory efforts, but not during relaxation. These studies confirm that twitch pressures induced by CMS during inspiratory efforts can be assessed at the mouth in normal subjects, providing a simple and non-invasive technique for assessing diaphragm activation during voluntary inspiratory efforts. Potentially, this technique could be made more sensitive and accurate and applied to detect submaximal efforts in patients.
Respiratory Medicine, NHLI, Imperial College School of Medicine, Hammersmith Hospital, London, UK.
P F
PF
de Bruin
R A
RA
Watson
N
N
Khalil
N B
NB
Pride
D000328:Adult; D003964:Diaphragm / Q000502:physiology*; D004558:Electric Stimulation; D004947:Esophagus / Q000502:physiology; D006801:Humans; D008280:Magnetics; D008297:Male; D009055:Mouth / Q000502:physiology; D018763:Muscle Fatigue / Q000502:physiology*; D010791:Phrenic Nerve / Q000502:physiology; D011312:Pressure; D012016:Reference Values; D015656:Respiratory Mechanics / Q000502:physiology; D012132:Respiratory Muscles / Q000502:physiology*; D013270:Stomach / Q000502:physiology