[From gene to behavior, a new method for elaboration of new psychotropic agents].
Traditionally, the screening of new neuropsychotropic agents started from the observation of behavioural effects resulting from the administration of a new chemical. Then, one tried to determine its mechanism of action. Since about a decade the way for discovering psychotropic agents tends to be inverse. It starts from the characterization of genes and investigates on their expression products which are new biological targets. Ligands for these targets are developed and then the effects resulting from their administration are considered. In this new strategy, we will consider the cloning of genes and their expression in cultured cells; the knock out of these genes by homologous recombinaison; the extinction of gene expression by antisense oligodeoxynucleotides; the concentration of behavioural phenotypes by selective breeding.
Costentin
J
J
Unité de Neuropsychopharmacologie Expérimentale, URA CNRS 1969, Faculté de Médecine et Pharmacie de Rouen, Saint-Etienne-du-Rouvray.
D000818:Animals; D030801:Animals, Genetically Modified; D001519:Behavior / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D005824:Genetics, Behavioral / Q000639:trends*; D006801:Humans; D011600:Psychopharmacology / Q000639:trends*; D011619:Psychotropic Drugs / Q000494:pharmacology*
D011619:Psychotropic Drugs
Du gène au comportement, un cheminement nouveau pour l'élaboration de nouveaux agents neuropsychotropes.