CD4(+) T-lymphocyte depletion in human lymphoid tissue ex vivo is not induced by noninfectious human immunodeficiency virus type 1 virions.
We tested infectious human immunodeficiency virus type 1 (HIV-1), noninfectious but conformationally authentic inactivated whole HIV-1 virions, and purified gp120 for the ability to induce depletion of CD4(+) T cells in human lymphoid tissues ex vivo. Infectious CXCR4-tropic HIV-1, but not matched inactivated virions or gp120, mediated CD4(+) T-cell depletion, consistent with mechanisms requiring productive infection.
Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1855, USA.
A W
AW
Sylwester
J C
JC
Grivel
W
W
Fitzgerald
J L
JL
Rossio
J D
JD
Lifson
L B
LB
Margolis
D015082:2,2'-Dipyridyl / Q000031:analogs & derivatives / Q000494:pharmacology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D004220:Disulfides / Q000494:pharmacology; D015699:HIV Envelope Protein gp120 / Q000276:immunology; D015497:HIV-1 / Q000187:drug effects / Q000276:immunology* / Q000472:pathogenicity*; D006801:Humans; D066298:In Vitro Techniques; D008231:Lymphopenia / Q000209:etiology / Q000276:immunology / Q000821:virology; D019718:Receptors, CXCR4 / Q000502:physiology; D014774:Virulence / Q000187:drug effects / Q000276:immunology
D004220:Disulfides; D015699:HIV Envelope Protein gp120; D019718:Receptors, CXCR4; C001105:2,2'-dipyridyl disulfide; D015082:2,2'-Dipyridyl