Antineurofilament antibodies in postpolio syndrome.
We determined the levels of antineurofilament antibodies in 29 patients with postpolio syndrome (PPS), 26 stable postpolio (PP) patients, 22 patients with ALS, and 20 normal controls (NCs). Patients with PPS had higher antibody levels to cholinergic neurofilaments than did all other groups. PP patients and those with ALS had antibody levels similar to those of NCs. The antibody binding level showed no relation to the age of the patients, duration of disease, or motor score.
Department of Neurology, Sourasky Medical Center, Tel-Aviv, Israel.
V E
VE
Drory
A
A
Shapira
A D
AD
Korczyn
S
S
Shavit
M
M
Kushnir
D M
DM
Michaelson
J
J
Chapman
D000328:Adult; D000690:Amyotrophic Lateral Sclerosis / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D002799:Cholinergic Fibers / Q000276:immunology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016900:Neurofilament Proteins / Q000276:immunology*; D016262:Postpoliomyelitis Syndrome / Q000276:immunology*; D013116:Spinal Cord / Q000166:cytology / Q000276:immunology
D001323:Autoantibodies; D016900:Neurofilament Proteins