Urinary N-acetyl-beta-glucosaminidase in the prediction of preeclampsia.
The urinary excretion of N-acetyl-beta-glucosaminidase (NAG), a lysosomal enzyme of the renal tubular cells was analyzed in 177 women divided into nonpregnant healthy controls (n = 46), normal pregnant women in their third trimester (n = 49), pregnant women with transient hypertension (n = 43), and women with preeclampsia (n = 39). Urinary activity of NAG was increased in normal pregnant women and in patients with transient hypertension in pregnancy compared to nonpregnant healthy controls. In preeclamptic women, this increase was found to be much higher than that corresponding to their gestational age; this fact is due to the tissue ischemia that precedes glomerular endotheliosis, but also tubular lesions caused by arteriolar vasoconstriction may have an important role.
Department of Internal Medicine, San Cecilio University Hospital and Mora Lara Medical Research Centre, University of Granada, Spain.
F J
FJ
Pérez-Blanco
M C
MC
Sanabria
J M
JM
Huertas
J
J
Cantero
A
A
Rodríguez-Cuartero
D000118:Acetylglucosaminidase / Q000652:urine*; D000328:Adult; D000419:Albuminuria / Q000652:urine; D004796:Clinical Enzyme Tests / Q000706:statistics & numerical data; D003404:Creatinine / Q000032:analysis; D005260:Female; D006801:Humans; D006973:Hypertension / Q000652:urine; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis* / Q000652:urine; D011247:Pregnancy; D011379:Prognosis; D012016:Reference Values; D018709:Statistics, Nonparametric; D014527:Uric Acid / Q000097:blood
D014527:Uric Acid; D003404:Creatinine; D000118:Acetylglucosaminidase