Deposition and dispersion of 1-micrometer aerosol boluses in the human lung: effect of micro- and hypergravity.
We performed bolus inhalations of 1-micrometer particles in four subjects on the ground (1 G) and during parabolic flights both in microgravity (microG) and in approximately 1.6 G. Boluses of approximately 70 ml were inhaled at different points in an inspiration from residual volume to 1 liter above functional residual capacity. The volume of air inhaled after the bolus [the penetration volume (Vp)] ranged from 200 to 1,500 ml. Aerosol concentration and flow rate were continuously measured at the mouth. The deposition, dispersion, and position of the bolus in the expired gas were calculated from these data. For Vp >/=400 ml, both deposition and dispersion increased with Vp and were strongly gravity dependent, with the greatest deposition and dispersion occurring for the largest G level. At Vp = 800 ml, deposition and dispersion increased from 33.9% and 319 ml in microG to 56.9% and 573 ml at approximately 1.6 G, respectively (P < 0.05). At each G level, the bolus was expired at a smaller volume than Vp, and this volume became smaller with increasing Vp. Although dispersion was lower in microG than in 1 G and approximately 1.6 G, it still increased steadily with increasing Vp, showing that nongravitational ventilatory inhomogeneity is partly responsible for dispersion in the human lung.
Darquenne
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C
Department of Medicine, University of California, San Diego, La Jolla, California 92093-0931, USA. cdarquenne@ucsd.edu
West
J B
JB
Prisk
G K
GK
D000280:Administration, Inhalation; D000328:Adult; D000336:Aerosols / Q000493:pharmacokinetics*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D018471:Hypergravity; D008168:Lung / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011137:Polystyrenes / Q000493:pharmacokinetics*; D014797:Vital Capacity; D014893:Weightlessness; D018474:Weightlessness Simulation
D000336:Aerosols; D011137:Polystyrenes; C024075:styrofoam