A second middle eastern kindred with autosomal recessive non-syndromic hearing loss segregates DFNB9.
A second kindred has been identified which supports the previously reported location of DFNB9. Linkage has been established to markers closely linked to DFNB9 which is located on 2p22-p23. The hearing impaired individuals in this highly consanguineous kindred from Eastern Turkey have prelingual profound hearing loss which affects all frequencies. A genetic map of the 2p22-p23 region where DFNB9 resides was generated using marker genotypes available from the CEPH database. All markers were placed on this genetic map using a likelihood ratio criterion of 1000:1. This map suggests that the region for DFNB9 is less than 1.08 cM, 95% confidence interval (0-2.59 cM).
Laboratory of Statistical Genetics, Rockefeller University, New York, USA. lealsm@rockvax.rockefeller.edu
S M
SM
Leal
F
F
Apaydin
C
C
Barnwell
M
M
Iber
T
T
Kandogan
M
M
Pfister
U
U
Braendle
O
O
Cura
M
M
Schwalb
H P
HP
Zenner
E
E
Vitale
D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D003638:Deafness / Q000235:genetics*; D005260:Female; D005808:Genes, Recessive; D008040:Genetic Linkage; D005838:Genotype; D009477:Hereditary Sensory and Autonomic Neuropathies / Q000235:genetics*; D006801:Humans; D008297:Male; D008877:Middle East; D010375:Pedigree