[Comparative study of the bactericidal activity of cefepime and cefpirome in association with glycopeptides against Staphylococci sensitive and resistant to methicillin].
The aim of this study was to evaluate by a kinetic time-kill method the synergy and bactericidal activity of cefepime and cefpirome in association with vancomycin and teicoplanin against 4 coagulase-positive and 7-negative staphylococci strains. Among these 2 were susceptible to methicillin and 7 resistant. Antibiotic concentrations used for time-kill curves were 0.5 and 1 CMI for glycopeptides and 32 mg/l for cephalosporins. Bactericidal activity was defined as a 3 log10 reduction of the initial inoculum. Cephalosporins at 32 mg/l and teicoplanin at 1 CMI were not bactericidal, while vancomycin at 1 CMI was bactericidal in 24 to 48 h for 3 strains. Cefepime and cefpirome in association with vancomycin were bactericidal against all strains with no secondary regrowth. Bactericidal activity was observed for 6 and 9 strains with the combinations of cefepime-teicoplanin and cefpirome-teicoplanin respectively. In conclusion, despite no significant antistaphylococcal activity of cefepime and cefpirome, their association to glycopeptides improved the bactericidal activity of vancomycin and teicoplanin.
Laboratoire de Bactériologie-Hygiène, Faculté de Médecine, Lille, France.
M O
MO
Husson
A
A
Fruchart
D
D
Izard
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000077723:Cefepime; D002511:Cephalosporins / Q000494:pharmacology; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D006020:Glycopeptides; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D013210:Staphylococcus / Q000187:drug effects*; D000097572:Cefpirome
D000900:Anti-Bacterial Agents; D000077723:Cefepime; D002511:Cephalosporins; D006020:Glycopeptides; D000097572:Cefpirome
Etude comparative de l'activité bactéricide du céfépime et du cefpirome en association avec les glycopeptides vis-à-vis de staphylocoques sensibles et résistants à la méthicilline.