Effects of delta-sleep-inducing peptide in cerebral ischemia in rats.
Experimental studies were carried out to investigate the neuroprotective effects of delta sleep-inducing peptide in animals with cerebral ischemia induced by bilateral compression of both carotid arteries, and to compare the efficacy of this peptide with that of MK-801. These studies led to the conclusion that the peptide had pronounced anti-ischemic effects, which were evident within 24 h and consisted of reductions in the severity of postural abnormalities in rats with bilateral cerebral ischemia, along with a reduction in lethality. Comparison of the efficacies of peptide and MK-801 showed the peptide to have the greater neuroprotective effect. These results are regarded as providing an experimental basis for using the peptide as a therapeutic agent in patients with stroke.
Shandra
A A
AA
Department of Normal Physiology, State Medical University, Odessa, Ukraine.
Godlevskii
L S
LS
Brusentsov
A I
AI
Vast'yanov
R S
RS
Karlyuga
V A
VA
Dzygal
A F
AF
Nikel
B
B
D000818:Animals; D002340:Carotid Artery Diseases / Q000150:complications / Q000503:physiopathology; D017536:Carotid Artery, Common / Q000503:physiopathology; D003701:Delta Sleep-Inducing Peptide / Q000627:therapeutic use*; D016291:Dizocilpine Maleate / Q000627:therapeutic use; D018691:Excitatory Amino Acid Antagonists / Q000627:therapeutic use; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D008297:Male; D010147:Pain Measurement / Q000187:drug effects; D011187:Posture / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar
D018691:Excitatory Amino Acid Antagonists; D003701:Delta Sleep-Inducing Peptide; D016291:Dizocilpine Maleate