Presence of 4-hydroxynonenal in cerebrospinal fluid of patients with sporadic amyotrophic lateral sclerosis.
A marker of lipid peroxidation 4-hydroxynonenal (HNE) was elevated in the cerebrospinal fluid (CSF) of a patient with sporadic amyotrophic lateral sclerosis (sALS) compared with that of most patients with other neurological diseases. Such elevations of HNE were sufficient to kill cyclic adenosine monophosphate (cAMP)-differentiated motor neuron hybrid cells in vitro, and anti-oxidants prevented this HNE-dependent cell death. These data suggest that oxidative stress and lipid peroxidation are associated with and may promote motor neuron degeneration in sALS.
Smith
R G
RG
Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.
Henry
Y K
YK
Mattson
M P
MP
Appel
S H
SH
D000447:Aldehydes / Q000134:cerebrospinal fluid* / Q000494:pharmacology; D000690:Amyotrophic Lateral Sclerosis / Q000134:cerebrospinal fluid*; D002460:Cell Line / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D006822:Hybrid Cells / Q000187:drug effects; D009046:Motor Neurons / Q000187:drug effects; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid
D000447:Aldehydes; C027576:4-hydroxy-2-nonenal