Does hyperconcentration result in platelet activation?. A flow-cytometric study of hyperconcentrated random donor platelets.
OBJECTIVE
Hyperconcentration of platelets may lead to platelet activation and loss of platelet function.


METHODS
Platelet activation following hyperconcentration was assessed using flow-cytometric detection of platelet P-selectin expression and platelet swirling.


RESULTS
Platelet hyperconcentration led to a minimal increase in P-selectin expression and no difference in platelet swirling.


CONCLUSIONS
Hyperconcentration was not associated with a clinically significant change in platelet activation and had no significant effect on platelet quality as detected by pH and platelet yield.
The University of Texas Health Science Center, San Antonio, Tex., USA.
T J
TJ
Gollehon
D E
DE
King
F E
FE
Craig
D001792:Blood Platelets / Q000502:physiology*; D002498:Centrifugation; D005434:Flow Cytometry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D019007:P-Selectin / Q000097:blood; D015539:Platelet Activation / Q000502:physiology*; D010976:Platelet Count
D019007:P-Selectin