Prevalence of Helicobacter pylori resistance to several antimicrobial agents in a region of Germany.
To evaluate the prevalence of resistance among Helicobacter pylori in Germany, the minimum inhibitory concentrations of amoxicillin, tetracycline, clarithromycin, and metronidazole were determined by means of the E test, for 271 Helicobacter pylori isolates cultured from biopsies taken during routine endoscopies in 1996 and 1997. The prevalence of metronidazole resistance was 32.1%, with resistance found more frequently in women (38.5%) than in men (24.4%). Clarithromycin resistance was rare (3.3%). Eight of nine strains resistant to clarithromycin were also resistant to metronidazole. Resistance to either metronidazole or clarithromycin was significantly (P=0.022) higher in patients with duodenal ulcer. No strain was found to be resistant to amoxicillin or tetracycline.
Institute of Medical Microbiology, Otto-von-Guericke University Magdeburg, Germany.
K
K
Wolle
M
M
Nilius
A
A
Leodolter
W A
WA
Müller
P
P
Malfertheiner
W
W
König
D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001706:Biopsy; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D004724:Endoscopy; D005260:Female; D005858:Germany; D016481:Helicobacter Infections / Q000382:microbiology*; D016480:Helicobacter pylori / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D013270:Stomach / Q000382:microbiology
D000900:Anti-Bacterial Agents