[The effect of dimethyl sulfoxide on the changes in the lymph microcirculation induced by staphylococcal toxin].
The effect of dimethyl sulfoxide (dimexid, DMSO) on the lymph microvessels of the rat mesentery was studied by vital biomicroscopy. It was found that 30% DMSO increases the tonus of intact lymph microvessels and stimulates their phase contractions. Action of the agent for more than 15 min leads to the development of lymphostasis. DMSO has a pronounced corrective effect on disorders of lymph microcirculation caused by the staphylococcal toxin. It removes the main lymphopathogenic effects of the poison and normalizes the drainage function of the lymphangions. The correcting effect of DMSO on lymph circulation is attended with attenuation of the fatal effect of the toxin.
Central Research Laboratory, Saratov, Russia.
G E
GE
Brill'
E I
EI
Zakharova
D000818:Animals; D001427:Bacterial Toxins / Q000633:toxicity*; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D004347:Drug Interactions; D007928:Lethal Dose 50; D008196:Lymph / Q000187:drug effects* / Q000502:physiology; D008208:Lymphatic System / Q000187:drug effects* / Q000502:physiology; D008643:Mesentery / Q000187:drug effects / Q000502:physiology; D051379:Mice; D051381:Rats; D013211:Staphylococcus aureus; D013997:Time Factors
D001427:Bacterial Toxins; D004121:Dimethyl Sulfoxide
Vliianie dimetilsul'foksida na izmeneniia limfomikrotsirkuliatsii, vyzvannye stafilokokkovym toksinom.