Effects of Synovex-S and recombinant bovine growth hormone (Somavubove) on growth responses of steers: III. Muscle growth and protein responses.
We conducted this study to determine whether the growth responses of specific skeletal muscles in crossbred beef steers were differentially affected by treatment with recombinant bovine growth hormone (Somavubove, SbV, .1 mg/kg BW, i.m., daily), Synovex-S (200 mg progesterone + 20 mg 17-beta estradiol benzoate, SYN, ear implant), or a combination of the two. Starting body weights of steers averaged 182+/-1.8 kg. Five steers were used at this average BW to obtain data on weight and composition of individual muscles at d 0, and 20 other steers were assigned in equal numbers to control (C, no implant and placebo daily injection), SYN, SbV, and SYN + SbV treatment groups. After 56 d of treatment with placebo or growth promoters, complete rectus femoris (RF), triceps brachii (TB), supraspinatus (SS), psoas major (PM), and semitendinosus (ST) muscles were dissected, weighed, and then ground for determination of moisture, total protein, and fat. To calculate the average daily muscle wet weight, protein, and fat gains, the initial weight, protein content, and fat content of a muscle were subtracted from those obtained at slaughter and the difference divided by 56. Muscle weight was increased over C in TB and SS by SYN (P < .1); in TB by SbV (P < .09); and in RF (P < .05), TB (P < .03), and SS (P < .03) by SYN + SbV. Overall average daily wet tissue gain was increased over C by SbV + SYN (P < .05) in RF, TB, and SS. Average daily protein gain in RF and TB was increased by SYN (P < .1), SbV (P < .06), and SYN + SbV (P < .01) over that calculated for C. For RF, TB, and SS, average daily protein gain was greater (P < . 1) in SbV + SYN than that obtained with SbV or SYN alone. These data suggest that administration of growth promoters, such as somatotropin and Synovex, to cattle differentially affects growth characteristics in certain muscles and can have additive effects on protein gain when used together.
Elsasser
T H
TH
Growth Biology Laboratory, Livestock and Poultry Sciences Institute, ARS-USDA, Beltsville, MD 20705-2350, USA.
Rumsey
T S
TS
Kahl
S
S
Czerwinski
S M
SM
Moseley
W M
WM
Ono
Y
Y
Solomon
M B
MB
Harris
F
F
Fagan
J M
JM
D000273:Adipose Tissue / Q000187:drug effects / Q000254:growth & development; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002417:Cattle / Q000254:growth & development*; D004338:Drug Combinations; D004347:Drug Interactions; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D013006:Growth Hormone / Q000494:pharmacology*; D008297:Male; D024510:Muscle Development; D009124:Muscle Proteins / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000254:growth & development; D009929:Organ Size / Q000187:drug effects; D011374:Progesterone / Q000494:pharmacology*; D011897:Random Allocation; D011994:Recombinant Proteins / Q000494:pharmacology
D004338:Drug Combinations; D009124:Muscle Proteins; D011994:Recombinant Proteins; D011374:Progesterone; D004958:Estradiol; C025370:estradiol benzoate, progesterone drug combination; D013006:Growth Hormone