Protein targeting: getting into the groove.
The 54 kDa subunit of the signal recognition particle has to identify a diverse family of substrates and deliver them in a controlled manner to the translocation machinery of the endoplasmic reticulum. Important new insights into the function of this sorting protein have emerged from recent biochemical and structural studies.
Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health Building 10, Room 9D-20, 10 Center Drive, Bethesda, Maryland 20892-1810, USA. harris_bernstein@nih.gov
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D000818:Animals; D008715:Methionine / Q000378:metabolism; D018271:Signal Recognition Particle / Q000378:metabolism*; D013379:Substrate Specificity
D018271:Signal Recognition Particle; D008715:Methionine