[Limbic encephalitis and SIADH revealing small-cell anaplastic lung cancer: MRI and immunologic findings].
Paraneoplastic limbic encephalitis (PLE) is a manifestation of clinico pathological entity encephalo-myelo-neuropathy associated with anti-neuronal antibodies type 1 (ANNA-1 also called anti-Hu). Isolated PLE is rare. We reported a case of PLE in a 61-year-old heavy smoker man. An inappropriate antidiuretic hormone secretion syndrome was associated. Cranial MRI showed hyperintensity in amygdalo-hippocampic regions on T2 weighted sequences which appeared hypointense on T1-weighted sequences without gadolinium enhancement. Anti-Hu antibodies were absent in serum and in CSF. Despite chemotherapy, he died 18 months after disease onset. Our patient presented PLE without myelonouropathy and without ANNA-1 which suggests a different immunopathology.
Service de Neurologie, Hôpital d'Instruction des Armées Legouest, Metz.
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E
Touzé
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JB
Auliac
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Carras
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G
Lecannelie
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M
Genero-Gygax
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F
Flocard
D000679:Amygdala / Q000473:pathology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001323:Autoantibodies / Q000097:blood / Q000134:cerebrospinal fluid; D018288:Carcinoma, Small Cell / Q000175:diagnosis* / Q000188:drug therapy; D004660:Encephalitis / Q000175:diagnosis / Q000209:etiology*; D017809:Fatal Outcome; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000209:etiology*; D008032:Limbic System / Q000473:pathology*; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000276:immunology; D010257:Paraneoplastic Syndromes / Q000175:diagnosis*
D001323:Autoantibodies
Encéphalite limbique et SIADH révélant un cancer pulmonaire anaplasique à petites cellules. Aspects IRM et immunologiques.