Functional determinants by which snake and cone snail toxins block the alpha 7 neuronal nicotinic acetylcholine receptors.
Snakes and cone snails produce toxins which block muscular and/or neuronal nicotinic acetylcholine receptors (AChRs). This paper mostly focuses on the determinants by which a snake long chain curaremimetic toxin and the cone snail toxin ImI bind specifically to the alpha 7 neuronal receptor. In both cases, the site involves a small turn-like structure constrained by two half-cystines.
Département d'Ingénierie et d'Etudes des Proteines, CEA-Saclay, Gif-sur-Yvette, France.
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Servent
H L
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Thanh
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Antil
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Bertrand
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Corringer
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JP
Changeux
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Ménez
D000595:Amino Acid Sequence; D000818:Animals; D018999:Charybdotoxin / Q000737:chemistry / Q000494:pharmacology; D020916:Conotoxins; D003472:Curare / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D004870:Erabutoxins / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D008969:Molecular Sequence Data; D008978:Mollusk Venoms / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D016297:Mutagenesis, Site-Directed; D009474:Neurons / Q000502:physiology*; D018733:Nicotinic Antagonists / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011978:Receptors, Nicotinic / Q000737:chemistry* / Q000378:metabolism*; D011993:Recombinant Fusion Proteins / Q000737:chemistry / Q000378:metabolism; D016415:Sequence Alignment; D012908:Snails; D012910:Snake Venoms / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D064569:alpha7 Nicotinic Acetylcholine Receptor
C579167:Chrna7 protein, human; D020916:Conotoxins; D008978:Mollusk Venoms; D018733:Nicotinic Antagonists; D009842:Oligopeptides; D011978:Receptors, Nicotinic; D011993:Recombinant Fusion Proteins; D012910:Snake Venoms; D064569:alpha7 Nicotinic Acetylcholine Receptor; D018999:Charybdotoxin; C087686:alpha-conotoxin ImI; D004870:Erabutoxins; D003472:Curare