[Systemic thrombolysis with plasminogen activator in chronic stroke patients].
Following the study protocol, we stratified the 615 patients of ECASS I according age (< or =/-70 years) and analysed the response to intravenous rt-PA in both subgroups. The older patients (248) suffered from the same stroke severity as the younger patients (367) experienced, however, a more severy clinical course (placebo group after 3 months after stroke: Barthel Index 50 vs. 85, mortality 24% vs. 11%). Treatment with rt-PA increased the proportion of undisabled patients at 3 months after stroke onset significantly only in the younger patients. The risk for brain parenchymal hemorrhage was increased by the factor of 4.7 and 4.6 in both age groups. It is obviously harder to achieve an undisabled state by systemic thrombolysis in the elderly. Facing the risk of brain hemorrhage associated with rt-PA, the risk-benefit-ratio may be less favourable in patients over 70 years.
von Kummer
R
R
Abteilung Neuroradiologie, Universitätsklinikum Carl Gustav Carus, TU Dresden.
Bluhmki
E
E
Ringleb
P
P
Hacke
W
W
D000203:Activities of Daily Living / Q000145:classification; D000328:Adult; D000368:Aged; D002543:Cerebral Hemorrhage / Q000139:chemically induced / Q000401:mortality; D002908:Chronic Disease; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D002542:Intracranial Embolism and Thrombosis / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D015912:Thrombolytic Therapy; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage* / Q000009:adverse effects; D016896:Treatment Outcome
D010959:Tissue Plasminogen Activator
Systemische Thrombolyse mit Plasminogenaktivator bei alten Schlaganfallpatienten.