Spermatozoa with chromosomal abnormalities may result in a higher rate of recurrent abortion.
OBJECTIVE
To determine whether sperm aneuploidy can lead to abortion.


METHODS
Clinical study.


METHODS
Couples with reproductive problems evaluated in a private diagnostic laboratory.


METHODS
Two men whose wives had histories of multiple abortions.


METHODS
Whole and Percoll-processed semen samples were analyzed.


METHODS
The results of fluorescence in situ hybridization.


RESULTS
Aneuploidy rates in Percoll-processed samples were higher than those found in whole specimens. Aneuploid spermatozoa also displayed greater motility.


CONCLUSIONS
Sperm aneuploidy should be studied before and after Percoll capacitation in all couples with unexplained infertility.
Sterility Department, Artemisia Medical Center, Rome, Italy.
C
C
Giorlandino
G
G
Calugi
L
L
Iaconianni
M L
ML
Santoro
A
A
Lippa
D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D000782:Aneuploidy; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D011247:Pregnancy; D013094:Spermatozoa / Q000502:physiology*