Acetylcholinesterase noncovalent inhibitors based on a polyamine backbone for potential use against Alzheimer's disease.
Melchiorre
C
C
Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
Andrisano
V
V
Bolognesi
M L
ML
Budriesi
R
R
Cavalli
A
A
Cavrini
V
V
Rosini
M
M
Tumiatti
V
V
Recanatini
M
M
D000110:Acetylcholinesterase / Q000378:metabolism; D000544:Alzheimer Disease / Q000188:drug therapy*; D001665:Binding Sites; D002091:Butyrylcholinesterase / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D004912:Erythrocytes / Q000201:enzymology; D006801:Humans; D007700:Kinetics; D008024:Ligands; D008958:Models, Molecular; D011073:Polyamines / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D043585:Receptor, Muscarinic M2; D011976:Receptors, Muscarinic / Q000378:metabolism; D013329:Structure-Activity Relationship
D002800:Cholinesterase Inhibitors; D008024:Ligands; D011073:Polyamines; D043585:Receptor, Muscarinic M2; D011976:Receptors, Muscarinic; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase