Innate immunity, cytokines, and pulmonary host defense.
Effective host defense against bacterial infection is dependent on the activation and recruitment of phagocytic cells. The initiation, maintenance, and resolution of this inflammatory response in the setting of bacterial pneumonia is dependent on the expression of cytokines. As the complexities of the host-pathogen interaction are further dissected and unraveled, immunologic manipulation of cytokine expression will likely become an important adjuvant therapy in the treatment of serious lung infections.
Department of Medicine, Louisiana State University Medical Center, New Orleans, USA.
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Nelson
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Summer
D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism; D001424:Bacterial Infections / Q000276:immunology*; D016207:Cytokines / Q000276:immunology* / Q000378:metabolism / Q000627:therapeutic use; D004195:Disease Models, Animal; D016179:Granulocyte Colony-Stimulating Factor / Q000276:immunology / Q000627:therapeutic use; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D008168:Lung / Q000276:immunology; D008171:Lung Diseases / Q000276:immunology*; D008262:Macrophage Activation; D016676:Macrophages, Alveolar / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology* / Q000378:metabolism; D018410:Pneumonia, Bacterial / Q000276:immunology / Q000382:microbiology; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
D000900:Anti-Bacterial Agents; D016207:Cytokines; D014409:Tumor Necrosis Factor-alpha; D016179:Granulocyte Colony-Stimulating Factor