[Studies on metabolism of 6-methoxy butyl phthalide by rat liver microsomes].
The in vitro biotransformation of 6-methoxy butyl phthalide (MBP) by phenobarbital induced rat liver microsomes was investigated by GC/MS and GC/MS with TMS derivatization. Three major metabolites of MBP were identified as 3-OH-MBP, 6-OH-butyl phthalide and gamma-OH-MBP. A less polar metabolite was tentatively identified as an epoxidation product.
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
S H
SH
Peng
Y Y
YY
Cui
T H
TH
Zhou
D000818:Animals; D000927:Anticonvulsants / Q000493:pharmacokinetics*; D001572:Benzofurans / Q000493:pharmacokinetics*; D001711:Biotransformation; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
C115231:6-methoxy butyl phthalide; D000927:Anticonvulsants; D001572:Benzofurans