Various forms of rabbit plasma alpha-1-antiproteinase.
Amino acid sequencing of the ficin-derived C-terminal fragments of alpha-1-antiproteinase (also called alpha-1-antitrypsin or alpha-1-proteinase inhibitor) prepared from rabbit plasma revealed the presence of the E isoform, which had been confirmed in the cDNA library in addition to the F and S-1 forms. The S-2 form was identified in inflamed rabbit plasma. The ficin digest of human plasma alpha-1-antitrypsin resulted in a major fragment of the M type. Multiple forms of alpha-1-antiproteinase in the rabbit plasma implicate the unknown functions other than the inhibition of neutrophil elastase.
Department of Biochemistry, School of Medicine, Kinki University, Osaka, Japan.
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A
Saito
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Sinohara
D000595:Amino Acid Sequence; D000818:Animals; D002845:Chromatography; D005361:Ficain / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000097:blood; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000097:blood / Q000737:chemistry; D020033:Protein Isoforms / Q000097:blood / Q000737:chemistry; D011817:Rabbits; D000515:alpha 1-Antitrypsin / Q000737:chemistry*
D010446:Peptide Fragments; D020033:Protein Isoforms; D000515:alpha 1-Antitrypsin; D005361:Ficain