[The effect of nedocromil sodium on spontaneous production of histamine releasing factor (HRF) by mononuclear blood cells in patients with nonatopic bronchial asthma].
The aim of the study was to evaluate the effect of 28-days antiinflammatory treatment with nedocromil sodium (Ned.sod.) (Tilade-8 mg/24 hours) on nonspecific bronchial hyperreactivity (PC20H in mg/ml) and spontaneous HRF activity production by mononuclear blood cells in patients with nonatopic bronchial asthma treated with beclomethasone dipropionate. The correlation between PC20H and HRF was also examined. The study was performed in 10 subjects with mild and moderate chronic, stable asthma in a double-blind, placebo-controlled way. Placebo and Ned. sod were given through 4 weeks in a randomized way with 8 weeks wash-out period. It was shown that Ned. sod. did not influence clinical asthma symptom scores, ventilatory parameters and PC20H. No changes in the spontaneous production of HRF activity were observed. The correlation between HRF activity and PC20H assessed 4 times was not significant. The authors conclude that studies with Ned. sod. in nonatopic asthma should be continued, but the dosage of the drug ought to be bigger and the time of treatment should to be longer.
Oddziału Ftizjopneumonologii Kliniki Pneumonologii i Alergologii IMW AM w Lodzi.
I
I
Grzelewska-Rzymowska
J
J
Grzegorczyk
J
J
Kroczyńska-Bednarek
W
W
Grabski
B
B
Kuźmińska
J
J
Rozniecki
D000328:Adult; D018927:Anti-Asthmatic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001249:Asthma / Q000097:blood* / Q000188:drug therapy*; D014408:Biomarkers, Tumor; D004311:Double-Blind Method; D005260:Female; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000378:metabolism; D008222:Lymphokines / Q000096:biosynthesis* / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D017835:Nedocromil / Q000494:pharmacology / Q000627:therapeutic use*; D000090324:Tumor Protein, Translationally-Controlled 1
D018927:Anti-Asthmatic Agents; D014408:Biomarkers, Tumor; D008222:Lymphokines; D000090324:Tumor Protein, Translationally-Controlled 1; D017835:Nedocromil
Wpływ nedokromilu sodu na samoistne wytwarzanie, przez komórki jednojadrowe krwi obwodowej, czynnika uwalniajacego histamine z bazofili (HRF) u chorych na nieatopowa astme oskrzelowa.