MRI in a patient with congenital agammaglobulinaemia.
MRI in a 17-year-old boy with known congenital agammaglobulinaemia (CA) demonstrated signs of chronic leptomeningeal inflammation with thickened, enhancing meninges. Furthermore, high signal was found symmetrically on T2-weighted images in the frontal and parietal white matter. The patient presented with severe general brain dysfunction and recent cerebellar ataxia. Extensive investigation did not reveal a causal agent. This case shows that MRI can be helpful in establishing the presence of pathological changes in cases where laboratory results are negative.
Ozdoba
C
C
Abteilung Neuroradiologie, Institut für Diagnostische Radiologie, Universität Bern/Inselspital, Switzerland.
Ramelli
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G
Schroth
G
G
D000293:Adolescent; D000361:Agammaglobulinemia / Q000175:diagnosis / Q000235:genetics*; D001921:Brain / Q000473:pathology*; D003937:Diagnosis, Differential; D005808:Genes, Recessive / Q000235:genetics; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008578:Meninges / Q000473:pathology; D008590:Meningoencephalitis / Q000175:diagnosis; D012729:Sex Chromosome Aberrations / Q000235:genetics; D014960:X Chromosome