[Apoptosis: the pharmacological aspects].
The article deals with the latest achievements in the interpretation of the mechanism of programmed cell death (apoptosis). The effect of drugs on the different stages of the apoptotic signal conduction is analysed. The earliest prospects of creating apoptosis regulating agents are planned. It is suggested that tests for apoptosis should be included in the list of obligatory ones in the preclinical studies of new biologically active compounds.
Department of Pharmacology, Russian State Medical University, Moscow, Russia.
D B
DB
Uteshev
A V
AV
Sergeev
B S
BS
Uteshev
D000818:Animals; D017209:Apoptosis / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D006801:Humans; D009336:Necrosis; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000502:physiology
D011956:Receptors, Cell Surface
Apoptoz: farmakologicheskie aspekty.