Interdependence of mycobacterial iron regulation, oxidative-stress response and isoniazid resistance.
Iron is an essential cofactor for vital functions in microorganisms. Bacterial pathogens have developed efficient iron-acquisition systems to counteract the defensive sequestration of iron by their hosts. In mycobacteria, the recently described protein, IdeR, negatively controls iron-uptake systems. This protein also has a role in the oxidative-stress response, as well as in resistance to the frontline antimycobacterial drug isoniazid.
Dussurget
O
O
Public Health Research Institute, New York, NY 10016, USA.
Smith
I
I
D000995:Antitubercular Agents / Q000378:metabolism / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000378:metabolism; D004352:Drug Resistance, Microbial; D007501:Iron / Q000493:pharmacokinetics*; D007538:Isoniazid / Q000378:metabolism / Q000494:pharmacology*; D009161:Mycobacterium / Q000187:drug effects* / Q000235:genetics / Q000502:physiology*; D018384:Oxidative Stress / Q000502:physiology*; D017262:Siderophores / Q000502:physiology
D000995:Antitubercular Agents; D001426:Bacterial Proteins; D017262:Siderophores; D007501:Iron; D007538:Isoniazid