Effects of lead exposure on licking and yawning behaviour in rats.
In the present study, effects of lead exposure on licking and yawning behaviour have been studied. The dopaminergic receptor agonist, apomorphine (0.15, 0.25 and 0.5 mg/kg), induced dose-dependent licking in rats. The maximum response was obtained with 0.5 mg/kg of the apomorphine. Lead acetate (0.05%) exposure significantly increased apomorphine-induced licking. Yawning induced by the D2 dopaminergic agonist, bromocriptine (2, 3, 4, 8 mg/kg), and the cholinergic drug, physostigmine (0.1 or 0.3 mg/kg), was significantly decreased by lead acetate (0.05%) exposure. It may be concluded that the behaviour induced by dopaminergic or cholinergic agents can be affected by lead subchronic exposure.
Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Iran.
M
M
Ghazi-Khansari
N
N
Rezvani
S
S
Bani-Assadi
M R
MR
Zarrindast
D000818:Animals; D001058:Apomorphine / Q000009:adverse effects; D001522:Behavior, Animal / Q000187:drug effects*; D001971:Bromocriptine / Q000009:adverse effects; D002800:Cholinesterase Inhibitors / Q000009:adverse effects; D018491:Dopamine Agonists / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D007855:Lead Poisoning; D008297:Male; D009942:Organometallic Compounds / Q000494:pharmacology*; D010830:Physostigmine / Q000009:adverse effects; D011042:Poisons / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D015000:Yawning / Q000187:drug effects*
D002800:Cholinesterase Inhibitors; D018491:Dopamine Agonists; D009942:Organometallic Compounds; D011042:Poisons; D001971:Bromocriptine; D010830:Physostigmine; D001058:Apomorphine; C008261:lead acetate