Necrotizing otitis externa, otitis media, peripheral facial paralysis, and brain abscess in a thalassemic child after allogeneic BMT.
Severe infection is one of the major complications in the early and late post-bone marrow transplantation period. The authors report a thalassemic child who developed necrotizing otitis externa and otitis media, a very rare complication after bone marrow transplantation, and then peripheral facial nerve paralysis and brain abscess in the early period of bone marrow transplantation despite antibacterial and antifungal prophylaxis. Necrotizing otitis media is characterized by necrosis and sloughing of considerable areas in the middle ear and adjacent tissues and is an unusual disorder because of today's antibiotics. Granulocytopenia and background ear tissue exposed to previous repeated otitis media attacks may be the predisposing factors in this case. The authors conclude that the children with previous histories of recurrent otitis media should be prepared and monitored very carefully during bone marrow transplantation because of the risk of necrotizing otitis media, especially in the granulocytopenic period.
Department of Pediatrics, Hacettepe University, Ihsan Doğramaci Children's Hospital, Ankara, Turkey.
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I
Tezcan
A M
AM
Tuncer
I
I
Yenicesu
M
M
Cetin
M
M
Ceyhan
M
M
Onerci
M
M
Ariyürek
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D001922:Brain Abscess / Q000209:etiology*; D002675:Child, Preschool; D005158:Facial Paralysis / Q000209:etiology*; D006801:Humans; D008297:Male; D009336:Necrosis; D010032:Otitis Externa / Q000209:etiology* / Q000473:pathology; D010033:Otitis Media / Q000209:etiology*; D014184:Transplantation, Homologous; D017086:beta-Thalassemia / Q000150:complications / Q000628:therapy*
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents