Restorative effect of Coriolus versicolor polysaccharides against gamma-irradiation-induced spleen injury in mice.
OBJECTIVE
To study the restorative effect of Coriolus versicolor polysaccharides (CVP) on spleen injury induced by gamma-ray irradiation in mice.


METHODS
ICR Male mice, 6-8 wk old, were divided at random into 3 groups: A) normal control; B) irradiated with 1 Gy; and C) after 1 Gy irradiation, given CVP 60 mg.kg-1 (ig) daily for 10 d continuously. Body weight (BW), spleen weight (SW), relative SW (RSW), DNA synthesis of splenocytes (DNA-SS), and relative DNA-SS were measured on d 5, 12, 19, 26, and 33 after irradiation.


RESULTS
SW, RSW, DNA-SS, and relative DNA-SS decreased after irradiation. CVP enhanced the recovery of SW, RSW, DNA-SS, and relative DNA-SS inhibited by irradiation.


CONCLUSIONS
CVP has the restorative effect against spleen injury induced by gamma-ray irradiation in mice.
Lin
I H
IH
Institute of Radiation Biology, National Tsing-Hua University, Taiwan, China.
Hau
D M
DM
Chang
Y H
YH
D000818:Animals; D001487:Basidiomycota / Q000737:chemistry; D004247:DNA / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011134:Polysaccharides / Q000302:isolation & purification / Q000627:therapeutic use*; D011509:Proteoglycans / Q000302:isolation & purification / Q000627:therapeutic use*; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D011897:Random Allocation; D013154:Spleen / Q000378:metabolism / Q000528:radiation effects; D014916:Whole-Body Irradiation
D011134:Polysaccharides; D011509:Proteoglycans; D011837:Radiation-Protective Agents; C010770:polysaccharide-K; D004247:DNA