[Cervical cancer and pregnancy: prognostic value of immunological response in nodes and cancer stroma].
Immune response in the stroma of cancer and in regional lymph nodes with regard to 5-years survival rate in 17 pregnant patients in which Wertheim-Meigs operation due to Ib cervical cancer was done, is assessed in this paper. Activation and hyperplasia of T and B dependent layers of lymph nodes as well as infiltration by monocyte-macrophage and lympho-plasmatic mature, immunocompetent cells are related to good prognosis and these are most frequent in patients with small invasion. Lack of immune response in lymph nodes, its poor expression, hemolymphatic transformation, adiposis of nodes or their fibrosis was found in 5 patients; 3 of them died within 5 years. Scare monocyte-macrophage infiltrations and low-differentiated lymphocytes prevailed in the stroma of cancer. Inactive answer in nodes and in stroma was found in 8 out of 12 patients who had deeper infiltration than 0.5 cm. Immunologic response in nodes and in stroma should be assessed as a routine method for all prognostic purposes. Patients with inactive immunologic response should be qualified for further treatment.
I Kliniki Ginekologii i Połoznictwa AM w Gdańsku.
J
J
Smutek
J
J
Mielnik
M
M
Jurczak
D000328:Adult; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000276:immunology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis*; D012189:Retrospective Studies; D017154:Stromal Cells / Q000276:immunology*; D015996:Survival Rate; D002583:Uterine Cervical Neoplasms / Q000276:immunology* / Q000401:mortality / Q000601:surgery
Wartość rokownicza immunologicznych odczynów komórkowych w podścielisku raka i w regionalnych wezłach chłonnych u ciezarnych z inwazyjnym rakiem szyjki macicy Ib.