[The effect of thymosin fractions on the development of compression edema-swelling of the brain].
The search for pathogenetically drugs for the treatment and prevention of edema-swelling of the brain (ESB) is one of the urgent problems of modern biology and medicine. Immune reactions take part in the development of pathological reactions in ESB formation. The antiedemic action of drugs affecting simultaneously the processes in the nervous and immune systems was studied. Such properties are possessed by regular peptides--thymosin fractions. It was demonstrated on a model that the antiedemic effect of thymic peptides under study was due to the influence of the mediator systems: serotonin and adrenergic. The data obtained allowed the antiedemic mechanism of the effect of thymoptin to be associated with its immunostimulating effect. At the same time, the antiedemic effect of thymalin is not connected directly with the immunostimulating action of the drug.
Platonov
I A
IA
Department of Pharmacology, Smolensk Medical Academy, Russia.
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D001834:Body Water / Q000187:drug effects; D001929:Brain Edema / Q000503:physiopathology / Q000517:prevention & control*; D004195:Disease Models, Animal; D004292:Dominance, Cerebral / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D051381:Rats; D013947:Thymosin / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D013951:Thymus Hormones / Q000627:therapeutic use*
D000276:Adjuvants, Immunologic; D013951:Thymus Hormones; C065652:timoptin; D013947:Thymosin; C032805:thymalin
Vliianie fraktsiĭ timozina na razvitie kompressionnogo oteka-nabukhaniia golovnogo mozga.