[The effects of betahistine on the function of equilibrium system].
The authors present a pilot investigation of the effect of betahistine on vestibular disorders of peripheral and central origin. The evaluation of drug efficacy was based on subjective symptoms (vertigo, dizziness) and values of nystagmus parameters in ENG. and stability records made during posturographic tests, before and after drug administration. The regression or moderation of symptoms, such as vertigo and dizziness, was noted as well as the reduction of nystagmus slow phase velocity and the amplitude and the reduction of parameters during posturographic test. The reduction was observed during the treatment, especially during the studies after 4 hours following drug administration. After 6 months, values of the parameters, especially those made during posturographic tests, were close to initial values. The criteria, helpful for diagnosing subjective ailments were discussed with the emphasis placed on the significance of the processes responsible for equilibrium system function return. The review was made of the literature concerning the role of betahistine in the treatment of vestibular disorders.
Kliniki Otolaryngologicznej Wojskowego Instytutu Medycyny Lotniczej w Warszawie.
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D000328:Adult; D000368:Aged; D001621:Betahistine / Q000494:pharmacology* / Q000627:therapeutic use*; D005260:Female; D017442:Histamine Agonists / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000188:drug therapy*; D008875:Middle Aged; D010865:Pilot Projects; D004856:Postural Balance / Q000187:drug effects*; D016896:Treatment Outcome
D017442:Histamine Agonists; D001621:Betahistine
Wpływ betahistyny na funkcje układu równowagi.