The armadillo family of structural proteins.
The armadillo gene is a segment polarity gene of Drosophila involved in signal transduction through wingless. Since the mid-1980s, a growing number of related proteins have been identified based on sequence homologies. These proteins share a central domain that is composed of a series of imperfect 45 amino acid repeats. Armadillo family members reveal diverse cellular locations reflecting their diverse functions. A single protein exerts several functions through interactions of its armadillo repeat domain with diverse binding partners. The proteins combine structural roles as cell-contact and cytoskeleton-associated proteins and signaling functions by generating and transducing signals affecting gene expression. The study of armadillo family members has made it increasingly clear that a distinction between structural proteins on the one hand and signaling molecules on the other is rather artificial. Instead armadillo family members exert both functions by interacting with a number of distinct cellular-binding partners.
Molecular Biology Group, Medical Faculty, University of Halle, Germany.
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Hatzfeld
D025601:Adenomatous Polyposis Coli Protein; D000818:Animals; D051186:Armadillo Domain Proteins; D015820:Cadherins / Q000502:physiology; D002448:Cell Adhesion / Q000502:physiology; D003598:Cytoskeletal Proteins / Q000235:genetics / Q000502:physiology; D051180:Desmoplakins; D004330:Drosophila / Q000235:genetics / Q000502:physiology; D029721:Drosophila Proteins; D017344:Genes, Insect; D014644:Genetic Variation; D006801:Humans; D019476:Insect Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D009369:Neoplasms / Q000209:etiology / Q000235:genetics; D010802:Phylogeny; D020449:Repetitive Sequences, Amino Acid; D015398:Signal Transduction / Q000502:physiology; D015534:Trans-Activators; D014157:Transcription Factors; D051176:beta Catenin
C495305:ARM protein, Drosophila; D025601:Adenomatous Polyposis Coli Protein; D051186:Armadillo Domain Proteins; C495270:CTNNB1 protein, human; D015820:Cadherins; D003598:Cytoskeletal Proteins; D051180:Desmoplakins; D029721:Drosophila Proteins; D019476:Insect Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D051176:beta Catenin