Congenital chylothorax in siblings.
We describe two cases of congenital chylothorax in siblings with important differences from previously described familial cases. Our findings support the likelihood of an autosomal recessive inheritance in some cases of this condition, rather than X-linked recessive inheritance, which has also been suggested. Autopsy findings from one of these cases and others previously described suggest that the pathophysiological mechanisms involved may be variable.
Perinatal Unit, Mount Sinai Hospital, and Fetal Diagnosis and Treatment Centre, University of Toronto, Canada.
G F
GF
Fox
D
D
Challis
K K
KK
O'Brien
E N
EN
Kelly
G
G
Ryan
D002916:Chylothorax / Q000151:congenital* / Q000000981:diagnostic imaging / Q000235:genetics*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009679:Nuclear Family; D011247:Pregnancy; D016216:Ultrasonography, Prenatal