[Frequency of the coreceptor CCR5 gene delta 32 mutation in different French regions].
We studied the frequency of the coreceptor CCR5 gene delta 32 mutation on 1,836 DNA samples originating from ten French regions. This mutation confers, in the homozygous state, resistance to HIV-1 infection. For the whole territory, the mean percentage presence of the delta 32 mutation is 9.2%. The mutation is statistically more frequent in the north (11.2%) than in the south (6.3%) of the country; this differentiation corresponds probably to a gradient of decreasing frequencies of the delta 32 mutation in Europe.
Institut international d'anthropologie, Paris, France.
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Lucotte
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Mercier
D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics; D004252:DNA Mutational Analysis; D005602:France; D005787:Gene Frequency; D006720:Homozygote; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D009154:Mutation; D016133:Polymerase Chain Reaction; D019713:Receptors, CCR5 / Q000235:genetics*
D019713:Receptors, CCR5
Fréquences de la mutation delta 32 du gène du corécepteur CCR5 dans les différentes régions françaises.