NIRS: dose dependency of local changes of cerebral HbO2 and Hb with pCO2 in parietal cortex.
Regional cerebral oxygenated hemoglobin and total hemoglobin increased systematically with increasing depth of hypercapnia, but the concentration of deoxygenated hemoglobin remained relatively constant. Relative mean changes of oxygenated and total hemoglobin increased nearly linearly, corresponding to the characteristic increase of the cerebral vascular dilation with increasing depth of hypercapnia.
Department of Anesthesia, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, USA.
P B
PB
Benni
C
C
Quick
B
B
Chen
H
H
Bada
C W
CW
Leffler
M L
ML
Daley
D000818:Animals; D001810:Blood Volume / Q000502:physiology; D001921:Brain / Q000098:blood supply*; D002245:Carbon Dioxide / Q000378:metabolism*; D006454:Hemoglobins / Q000378:metabolism*; D010108:Oxyhemoglobins / Q000378:metabolism*; D010296:Parietal Lobe / Q000098:blood supply*; D012039:Regional Blood Flow / Q000502:physiology; D019265:Spectroscopy, Near-Infrared; D013552:Swine; D014664:Vasodilation / Q000502:physiology
D006454:Hemoglobins; D010108:Oxyhemoglobins; D002245:Carbon Dioxide