Fine needle aspiration cytology of fibrous dysplasia: a case report.
BACKGROUND
Fibrous dysplasia (FD) is a benign disorder of bone consisting of intramedullary proliferation of fibrous tissue and irregularly distributed, poorly developed bone. Although tumorlike in appearance, FD is probably a condition resulting from failure of maturation from woven to lamellar bone. The histology of FD has been well characterized since Lichtenstein first reported it, in 1938; however, the cytologic appearance has been described only rarely. To our knowledge, this is the first case report of fine needle aspiration (FNA) cytomorphology of FD.


METHODS
A 30-year-old female with breast carcinoma, diagnosed a month earlier, underwent computed tomography-guided FNA of a rib lesion radiologically thought to represent FD, although metastatic cancer could not be excluded. The smears contained blood, occasional osteoclastic multinucleated giant cells and frequent C-shaped fibrillary structures with dark central areas and lighter peripheries, representing woven bone. The cytologic/radiologic impression of FD was confirmed histologically.


CONCLUSIONS
FNA cytodiagnosis of FD is possible in the setting of consistent clinical and radiologic findings.
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Department of Pathology, University of Wisconsin Hospital and Clinics, Madison, USA.
Kurtycz
D F
DF
Wojtowycz
M
M
Inhorn
S L
SL
D000328:Adult; D001707:Biopsy, Needle / Q000379:methods; D005260:Female; D005358:Fibrous Dysplasia, Monostotic / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D011859:Radiography; D012272:Ribs