[Intravenous iron in the treatment of postoperative anemia in surgery of the spine in infants and adolescents].
OBJECTIVE
Spinal fusion surgery often leeds to massive bleeding responsible for anemia in the postoperative period. The aim of this study was to compare the effect of IV iron III hydroxide sucrose complex (Venofer) versus oral iron fumarate administration in postoperative anemia. The efficacy of both treatments was evaluated by comparing hemoglobin level in the postoperative period.


METHODS
Two groups of sixteen patients, scheduled for anterior and/or posterior spinal fusion, were compared. Group 1, historical, was treated by supplementation of 10 mg/kg/day oral iron fumarate. Administration was started when hemoglobin level fell below 9 g/100 ml. Group 2 was treated by intravenous iron sucrose complex using same criteria as in group 1 for starting administration. The dosage of iron was individually adapted according to a target hemoglobin level of 13 g/100 ml and to the actual lowest hemoglobin level measured. The total iron deficit was calculated with the following formula: total iron deficit (mg) = 0.24 x body weight (kg) x (target Hb-actual Hb)(g/l). The patients were supplemented by 3 mg/kg/day until the calculated iron deficit was compensated.


RESULTS
Both groups were identical regarding age and lowest hemoglobin level reached in the postoperative period. Hemoglobin increased by 0.25 g/day in group 1, and by 0.36 g/day in group 2. In others words, the beneficial effect of IV iron versus oral iron administration was as high as 45 per cent (p = 0.003).


CONCLUSIONS
Intravenous iron therapy as ferric sucrose complex is a new and more effective form of iron therapy than oral iron therapy to restore postoperative hemoglobin after spinal surgery in children.
Département d'Anesthésie-Réanimation, Hôpital Armand Trousseau, Paris.
J
J
Bernière
J P
JP
Dehullu
O
O
Gall
I
I
Murat
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000740:Anemia / Q000097:blood / Q000628:therapy*; D016063:Blood Loss, Surgical; D002648:Child; D002675:Child, Preschool; D005290:Ferric Compounds / Q000008:administration & dosage*; D000077605:Ferric Oxide, Saccharated; D005937:Glucaric Acid; D006801:Humans; D007275:Injections, Intravenous; D007501:Iron / Q000008:administration & dosage*; D011183:Postoperative Complications / Q000097:blood / Q000628:therapy*; D013123:Spinal Fusion / Q000009:adverse effects*; D013395:Sucrose / Q000008:administration & dosage*
D005290:Ferric Compounds; D013395:Sucrose; D007501:Iron; D000077605:Ferric Oxide, Saccharated; D005937:Glucaric Acid
Le fer intraveineux dans le traitement des anémies postopératoires dans la chirurgie du rachis de l'enfant et de l'adolescent.