Granulocytic sarcoma presented as a reactivation of chronic myeloid leukemia after allogenic marrow transplantation.
The authors report the case of a chronic myeloid leukemia (CML) patient submitted to allogenic bone marrow transplantation, who had probably never entered complete remission. The disease was reactivated as a granulocytic sarcoma, next to a platinum plate installed to correct a tibia fracture 11 years earlier. Its final event was a myeloid Ph1 + blastic crisis that was unsuccessfully treated with high doses of sc interferon and citarabine.
Department of Pathology, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brazil. unifesp@epm.br
J S
JS
de Oliveira
M de L
Mde L
Chauffaille
G W
GW
Colleoni
V M
VM
Morelli
O M
OM
Hauache
V N
VN
Alberti
J
J
Kerbauy
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001752:Blast Crisis / Q000188:drug therapy; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D003561:Cytarabine / Q000627:therapeutic use; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007372:Interferons / Q000627:therapeutic use; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D007951:Leukemia, Myeloid / Q000209:etiology; D012008:Recurrence
D000970:Antineoplastic Agents; D003561:Cytarabine; D007372:Interferons