Cysteinyl-leukotriene levels in intracerebral hemorrhage: an edema-promoting factor?
In 12 operatively (stereotactic aspiration and recombinant tissue-type plasminogen activator, rTPA) and 5 conservatively treated patients with spontaneous intracerebral hemorrhage the amounts of cysteinyl-leukotriene (cys-LT) released by blood-brain cell contact were measured by the urinary excretion of their metabolites during treatment. The mean cys-LT release before treatment was 14.51 +/- 1.13 pg/mg creatinine/ml hematoma volume. The urinary cys-LT excretion at the end of the measurements was significantly lower in the operatively treated group than in the patients with conservative therapy (p < 0.05). We also found a significant correlation between the perifocal edema volume and the amount of cys-LT measured in patients' urine (p < 0.01). In an additional animal experiment using dissociated rat brain cells plasmin was excluded as an activator for cerebral cys-LT formation, which emphasizes that rTPA did not influence cys-LT formation.
Neurosurgical Clinic, Justus Liebig University, Giessen, Germany. michael.winking@neuro.med.uni-giessen.de
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M
Winking
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W
Deinsberger
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A
Joedicke
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DK
Boeker
D000818:Animals; D001921:Brain / Q000166:cytology; D001923:Brain Chemistry; D001929:Brain Edema / Q000378:metabolism*; D002478:Cells, Cultured; D002543:Cerebral Hemorrhage / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D003404:Creatinine / Q000652:urine; D003545:Cysteine / Q000032:analysis / Q000652:urine*; D005260:Female; D005341:Fibrinolysin / Q000378:metabolism; D006406:Hematoma / Q000378:metabolism; D006801:Humans; D015289:Leukotrienes / Q000032:analysis / Q000652:urine*; D008297:Male; D008875:Middle Aged; D051381:Rats; D017208:Rats, Wistar
D015289:Leukotrienes; C112381:cysteinyl-leukotriene; D003404:Creatinine; D005341:Fibrinolysin; D003545:Cysteine