Effects of aortic nerve stimulation on discharges of sympathetic neurons innervating rat tail artery and vein.
Activity was recorded from postganglionic sympathetic neurons (PSNs) innervating either the caudal ventral artery (CVA) or a lateral vein (LV) of the tail circulation of anesthetized rats. The study sought to determine whether sympathetic activity directed at the CVA and LV was influenced by cardiovascular mechanoreceptor afferents and whether this effect was differential. Cardiac rhythmicity was not a robust component of either CVA PSN activity or LV PSN activity. Stimulation of an aortic nerve with short trains was followed by a decreased probability of discharge in both CVA and LV PSNs that was followed by a series of peaks that showed a constant periodicity that was not significantly different from that revealed by autocorrelogram analysis over the same data set. The latter dominant periodicity is referred to in this and related previous publications as the T rhythm. Furthermore, blood volume expansion and long-train aortic nerve stimulation produced a significant decrease in the frequency of the T rhythm. It is concluded that the CVA and LV sympathetic activity can be influenced by inputs from cardiovascular mechanoreceptors and that this effect is mediated in part by a modulation of the T rhythm.
Autonomic Neuroscience Institute, Department of Physiology, Royal Free Hospital School of Medicine, London NW3 2PF, United Kingdom.
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Johnson
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Gilbey
D000200:Action Potentials; D000818:Animals; D001011:Aorta / Q000294:innervation*; D001158:Arteries / Q000294:innervation*; D004558:Electric Stimulation; D004562:Electrocardiography; D006339:Heart Rate / Q000502:physiology; D008297:Male; D009200:Myocardial Contraction; D009474:Neurons / Q000502:physiology*; D010791:Phrenic Nerve / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013564:Sympathetic Nervous System / Q000502:physiology*; D013623:Tail / Q000098:blood supply; D014680:Veins / Q000294:innervation*