[Effects of Peucedanum praeruptorum extractum on blood pressure, left ventricular hypertrophy and hemodynamic changes in left ventricular hypertrophied hypertensive rats].
After intragastric administration of Peucedanum praeruptorum (PPE) 0.6 g/100 g body weight, the blood pressure was decreased significantly in both the normal and the left ventricular hypertrophied hypertensive (LVH) rats. The PPE could still prevent the formation of the left ventricular hypertrophy in renovascular hypertensive rats, the ratio of weight of left ventricular over the weight of body was reduced markedly than that of the LVH group, and was nearly the same of the sham-operated group. The PPE could improve both the systolic and diastolic function than that of the LVH group in the isolated heart, especially, the flow of the coronary artery was increased significantly.
Dept. of Cardiovascular Pharmacology, Nanjing Medical University.
Y
Y
Ji
M R
MR
Rao
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003326:Coronary Circulation / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006978:Hypertension, Renovascular / Q000503:physiopathology*; D017379:Hypertrophy, Left Ventricular / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley
D004365:Drugs, Chinese Herbal