Induction of matrix metalloproteinase-2 in human immunodeficiency virus-1 glycoprotein 120 transgenic mouse brains.
Human immunodeficiency virus (HIV)-1 can invade the brain and cause degeneration of the central nervous system, resulting in a host of cognitive and motor impairments. HIV-1 glycoprotein 120 (gp120), has been implicated in the neurodegenerative effects of HIV infection. Here, gp120's neurotoxic potential is demonstrated in both transgenic mice and cultured cells. We observed that gp120 causes an induction of matrix metalloproteinase (MMP)-2 activity and protein in transgenic mouse brains and in transfected C6 cells. We propose that induced MMP-2 may contribute to a neurodegenerative environment by degrading extracellular matrix (ECM) fibronectin and type IV collagen.
Department of Biochemistry, The Arthritis Center, Boston University School of Medicine, MA 02118-2394, USA.
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DC
Marshall
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Wyss-Coray
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Abraham
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002461:Cell Line, Transformed; D004790:Enzyme Induction / Q000502:physiology; D018093:Gelatinases / Q000378:metabolism*; D015699:HIV Envelope Protein gp120 / Q000235:genetics / Q000502:physiology*; D020778:Matrix Metalloproteinase 2; D008666:Metalloendopeptidases / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic / Q000235:genetics; D009498:Neurotoxins / Q000378:metabolism; D051381:Rats; D014162:Transfection
D015699:HIV Envelope Protein gp120; D009498:Neurotoxins; D018093:Gelatinases; D008666:Metalloendopeptidases; D020778:Matrix Metalloproteinase 2