Fixed drug eruption induced by indapamide. Cross-reactivity with sulfonamides.
Indapamide is a nontiazidic sulfonamide diuretic which has not been previously reported as a cause of fixed drug eruption. We describe a patient who experienced several episodes of fixed drug eruption during treatment with indapamide. The diagnosis was confirmed by positive controlled oral challenge test. The possible existence of cross-reactivity with other sulfonamide derivatives was investigated by controlled oral challenge test with sulfamethoxazole, sulfadiazine and furosemide, with the tests with sulfamethoxazole and sulfadiazine resulting positive.
De Barrio
M
M
Section of Allergology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Tornero
P
P
Zubeldia
J M
JM
Sierra
Z
Z
Matheu
V
V
Herrero
T
T
D000368:Aged; D000959:Antihypertensive Agents / Q000009:adverse effects / Q000276:immunology*; D003429:Cross Reactions; D003875:Drug Eruptions / Q000276:immunology* / Q000473:pathology; D004342:Drug Hypersensitivity / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D007190:Indapamide / Q000009:adverse effects / Q000276:immunology*; D013449:Sulfonamides / Q000276:immunology*
D000959:Antihypertensive Agents; D013449:Sulfonamides; D007190:Indapamide