[The immunological efficacy of the combined vaccine Trimovax intended for the prevention of measles, mumps and rubella].
In 1996 the immunization of children against measles, mumps and rubella with combined vaccine Trimovax ("Pasteur Mérieux Connaught", France) was carried out in the Republic of Belarus. The reactogenicity of the vaccine was studied in 372 children. To evaluate immunological effectiveness, the sera of 324 children were used. Postvaccinal reactions of different intensity were registered in 5.6% of the children; of these, 1.3% exhibited severe reactions. Among the vaccinees, protective titers of antibodies to measles were found in 97.6% to mumps, in 93.8% and to rubella, in 96.0% of the children. Antibodies to all three components of the vaccine were present mainly in high and moderate titers. The results thus obtained indicate that, Trimovax was well tolerated and proved to be immunologically active.
Research Institute of Microbiology and Epidemiology, Republican Centre of Hygiene and Epidemiology, Minsk, Republic of Belarus.
E O
EO
Samoĭlovich
L A
LA
Kapustik
E V
EV
Fel'dman
M A
MA
Ermolovich
E Iu
EIu
Svirchevskaia
L P
LP
Titov
D F
DF
Zakharenko
E Iu
EIu
Belova
M A
MA
Chernovetskiĭ
T S
TS
Korostik
D000914:Antibodies, Viral / Q000097:blood; D004341:Drug Evaluation; D006801:Humans; D007223:Infant; D008457:Measles / Q000517:prevention & control*; D008458:Measles Vaccine / Q000009:adverse effects / Q000276:immunology*; D008459:Measles virus / Q000276:immunology; D022542:Measles-Mumps-Rubella Vaccine; D009107:Mumps / Q000517:prevention & control*; D009108:Mumps Vaccine / Q000009:adverse effects / Q000276:immunology*; D009109:Mumps virus / Q000276:immunology; D002094:Republic of Belarus; D012409:Rubella / Q000517:prevention & control*; D012411:Rubella Vaccine / Q000009:adverse effects / Q000276:immunology*; D012412:Rubella virus / Q000276:immunology; D013997:Time Factors; D014505:Urban Population; D017778:Vaccines, Combined / Q000009:adverse effects / Q000276:immunology
D000914:Antibodies, Viral; D008458:Measles Vaccine; D022542:Measles-Mumps-Rubella Vaccine; D009108:Mumps Vaccine; D012411:Rubella Vaccine; D017778:Vaccines, Combined
Immunologicheskaia éffektivnost' assotsiirovannoĭ vaktsiny Trimovaks, prednaznachennoĭ dlia profilaktiki kori, parotita i krasnukhi.