Epidemiological data in polycythaemia vera: a study of 842 cases.
An epidemiological study of 842 polycythaemic patients (entered between 1980 and 1997 in the French investigational prospective protocols) is presented. The global incidence is approximately 0.8-1.5/100,000/year in the reference area (Ile-de-France and surrounding areas). It increases linearly with age until 80, which suggests that several mutational somatic events are necessary. There was a slight male excess (sex-ratio 1.2, after correction for the percentage of male and female French people still living at risk). We did observe a slight excess of PV in the population of Jewish ancestry. A surprising excess of former blood donors (20.7% of the PV cases, compared to 8% estimated in the reference population) was observed. Only a few cases of familial myeloproliferative diseases and occurence of leukemia in the family of our patients have been observed; even if slight, this excess is statistically significant. In contrast, no excess of carcinomas was observed either in the family or in the patients' antecedents. We did not find any excess of radiation exposure in our cases. When analysing the previous occupation of our patients a possible excess of physicians and of patients previously working in occupations using solvents and glues was found, but this finding needs confirmation.
Service de Médecine Nucléaire, Hôpital Saint-Louis, Paris, France.
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Najean
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Rain
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Billotey
D000269:Adhesives / Q000009:adverse effects; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001782:Blood Donors; D002423:Cause of Death; D015897:Comorbidity; D005192:Family Health; D005260:Female; D005602:France / Q000453:epidemiology; D020022:Genetic Predisposition to Disease; D006282:Health Personnel; D006801:Humans; D015994:Incidence; D007221:Industry; D007585:Jews / Q000235:genetics; D007938:Leukemia / Q000453:epidemiology / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000453:epidemiology / Q000235:genetics; D009369:Neoplasms / Q000453:epidemiology / Q000235:genetics; D009784:Occupational Diseases / Q000139:chemically induced / Q000453:epidemiology; D016273:Occupational Exposure; D011087:Polycythemia Vera / Q000453:epidemiology* / Q000208:ethnology / Q000235:genetics; D011446:Prospective Studies; D012997:Solvents / Q000009:adverse effects
D000269:Adhesives; D012997:Solvents