MRI in a patient with congenital agammaglobulinaemia.
MRI in a 17-year-old boy with known congenital agammaglobulinaemia (CA) demonstrated signs of chronic leptomeningeal inflammation with thickened, enhancing meninges. Furthermore, high signal was found symmetrically on T2-weighted images in the frontal and parietal white matter. The patient presented with severe general brain dysfunction and recent cerebellar ataxia. Extensive investigation did not reveal a causal agent. This case shows that MRI can be helpful in establishing the presence of pathological changes in cases where laboratory results are negative.
Abteilung Neuroradiologie, Institut für Diagnostische Radiologie, Universität Bern/Inselspital, Switzerland.
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Ozdoba
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Ramelli
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Schroth
D000293:Adolescent; D000361:Agammaglobulinemia / Q000175:diagnosis / Q000235:genetics*; D001921:Brain / Q000473:pathology*; D003937:Diagnosis, Differential; D005808:Genes, Recessive / Q000235:genetics; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008578:Meninges / Q000473:pathology; D008590:Meningoencephalitis / Q000175:diagnosis; D012729:Sex Chromosome Aberrations / Q000235:genetics; D014960:X Chromosome