HLA evidence for the lack of genetic heterogeneity in Basques.
To examine the possible internal heterogeneity within the Basque population, nine samples typed for several HLA loci were compiled and HLA-A, B, C and DR loci were analysed. First, the shared features of HLA in Basques were analysed by principal component analysis and genetic distances. Two major Basque dialect groups ('French' and 'Spanish') were considered. FST statistics were computed and corrected for sampling intensity. The dialectal and political division did not seem to differentiate these two groups genetically. Analysis of Molecular Variance also failed to show consistently significant genetic variance components between French and Spanish Basques. Thus, in this particular example, linguistic diversity does not seem to correlate with a genetic stratification.
Departament de Biologia Animal, Facultat de Biologia, Universitat de Barcelona, Spain.
D
D
Comas
F
F
Calafell
E
E
Mateu
A
A
Pérez-Lezaun
J
J
Bertranpetit
D000483:Alleles; D000704:Analysis of Variance; D005006:Ethnicity / Q000235:genetics*; D005602:France; D005787:Gene Frequency; D014644:Genetic Variation; D006680:HLA Antigens / Q000097:blood / Q000145:classification* / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D013030:Spain
D006680:HLA Antigens