[Ethanol-induced injury and GI bleeding].
Ethanol-induced injury of digestive organs closely linked to the GI bleeding. The gastric or esophageal mucosal hemorrhage evoked by extra-amounts of alcohols is initiated by the microcirculatory damage of gastrointestinal mucosa. Many investigators focused on the ethanol-induced gastric ulcer formation as well as the ethanol-induced gastroesophageal reflux injury. Although the most important treatment for such a damage is of course to stop the drinking, it is also important to protect the gastrointestinal mucosa by potentiate the mucosal defense systems.
Suzuki
H
H
Department of Internal Medicine, School of Medicine, Keio University.
Kajiwara
M
M
Miura
S
S
Ishii
H
H
D000434:Alcoholic Beverages / Q000009:adverse effects*; D000818:Animals; D000431:Ethanol / Q000009:adverse effects*; D005609:Free Radicals; D005753:Gastric Mucosa / Q000098:blood supply; D005764:Gastroesophageal Reflux / Q000139:chemically induced; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced*; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D007511:Ischemia / Q000150:complications; D008833:Microcirculation; D018384:Oxidative Stress
D005609:Free Radicals; D000431:Ethanol; D005978:Glutathione