Effects of cefepime, cefixime and ceftibuten on murine gut colonization by Candida albicans.
Crl:CD1(ICR) BR mice were fed chow containing Candida albicans or regular chow. Both groups were subsequently given either antibiotics or normal saline. Stool cultures were performed before, at the end of treatment and 1 week after treatment, to determine the effect on the stool yeast concentration. Candida-colonized mice treated with cefepime, cefixime or ceftibuten had higher (however not significantly) counts of the yeast in their stools than control Candida-fed mice treated with saline. A group of Candida-fed mice were treated with ceftriaxone, which is known to increase the yeast stool concentration significantly and served as positive control. Mice fed regular chow and treated with the study drugs or saline did not have any yeasts in their stools. Dissemination of Candida did not occur.
The University of Crete, Division of Medicine, Heraklion, Crete, Greece.
S
S
Maraki
E
E
Barbounakis
I
I
Chatzinikolaou
N
N
Anatoliotakis
M
M
Plataki
Y
Y
Tselentis
G
G
Samonis
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D002177:Candidiasis / Q000188:drug therapy / Q000382:microbiology; D000077723:Cefepime; D020682:Cefixime; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000494:pharmacology; D000077722:Ceftibuten; D002511:Cephalosporins / Q000494:pharmacology*; D004064:Digestive System / Q000187:drug effects / Q000382:microbiology*; D004195:Disease Models, Animal; D051379:Mice; D008813:Mice, Inbred ICR
D000935:Antifungal Agents; D002511:Cephalosporins; D000077723:Cefepime; D020682:Cefixime; D000077722:Ceftibuten; D002439:Cefotaxime