[The neurotropic activity of peptide immunomodulators].
Four-day monitoring using standard methods of studying free group behavior of animals in an "open field" (Opto-Varimex, USA) showed that all the peptide immunomodulators under study possessed a neuromodulating effect comparable with that of known drugs. They change the character of the circadian rhythms of the animals' motor activity and the dynamics of extinction of the orientation-investigation reaction. In comparison with the control the activity of the drugs under study was distributed as follows: ethymizol > cerebrolysin > thymalin > nootropil > thymogen > T-activin > cortexin > dibazol.
Military Medical Academy, St. Petersburg, Russia.
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Grechko
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D008297:Male; D010455:Peptides / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000276:Adjuvants, Immunologic; D010455:Peptides
Neĭrotropnaia aktivnost' peptidnykh immunomoduliatorov.