Development of a heterologous model in germfree suckling rats for studies of rotavirus diarrhea.
Germfree suckling rats were infected with an SA11 rotavirus strain. Infected pups developed diarrhea associated with histopathological changes. The virus was detected in feces and in the small intestine. Cellular vacuolation was observed in the villi of the jejunum. These results provide a new model for further investigations of group A rotavirus infection.
Guerin-Danan
C
C
Unité d'Ecologie et de Physiologie du Système Digestif, Equipe Métabolites Bactériens et Santé, INRA, 78352 Jouy-en-Josas Cedex, France.
Meslin
J C
JC
Lambre
F
F
Charpilienne
A
A
Serezat
M
M
Bouley
C
C
Cohen
J
J
Andrieux
C
C
D000818:Animals; D000833:Animals, Suckling; D000956:Antigens, Viral / Q000378:metabolism; D003967:Diarrhea / Q000209:etiology* / Q000821:virology; D004195:Disease Models, Animal; D005243:Feces / Q000821:virology; D005856:Germ-Free Life; D007421:Intestine, Small / Q000821:virology; D007583:Jejunum / Q000473:pathology / Q000821:virology; D051381:Rats; D011916:Rats, Inbred F344; D012401:Rotavirus / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity*; D012400:Rotavirus Infections / Q000209:etiology* / Q000473:pathology / Q000821:virology; D014617:Vacuoles / Q000473:pathology
D000956:Antigens, Viral