[Gopten (trandolapril) in the treatment of chronic heart failure in patients with ischemic heart disease].
OBJECTIVE
To investigate clinical efficacy of angiotensin-converting enzyme inhibitor trandolapril and its effects on myocardial function.


METHODS
20 patients with ischemic heart disease (IHD) aged 33-74 years with chronic cardiac failure NYHA class II-IV. 4 of them survived myocardial infarction. In addition to the routine tests, the patients underwent echocardiography, radionuclide ventriculography. Trandolapril was given once a day for 28 days in a dose 2 mg, then a repeat examination was performed.


RESULTS
Trandolapril produced a subjective effect in 80% of patients. There was also improvement of hemodynamic parameters, an increase in the ejection fraction, sensitivity to nitroglycerin, decline of asynchrony. The drug was well tolerated.


CONCLUSIONS
Trandolapril (Gopten) is effective in IHD patients with chronic cardiac failure.
Kakhnovskiĭ
I M
IM
Fomina
I G
IG
Ostroumov
E L
EL
Lepeshkov
V M
VM
Gaĭdamakina
N E
NE
Kaveshnikova
O V
OV
Markova
Z S
ZS
Lugovaia
E L
EL
D000328:Adult; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D002908:Chronic Disease; D004341:Drug Evaluation; D005260:Female; D006333:Heart Failure / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D007211:Indoles / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects; D017202:Myocardial Ischemia / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology
D000806:Angiotensin-Converting Enzyme Inhibitors; D007211:Indoles; C052035:trandolapril
Gopten (trandolapril) pri lechenii khronicheskoĭ serdechnoĭ nedostatochnosti u bol'nykh ishemicheskoĭ bolezn'iu serdtsa.