The capsule biosynthetic locus of Pasteurella multocida A:1.
Pasteurella multocida is the aetiological agent of fowl cholera, bovine haemorrhagic septicaemia and atrophic rhinitis in pigs. Many strains of P. multocida express a capsule on their surface. However, nothing is known about the capsule biosynthetic locus in P. multocida although the capsule has been implicated as a virulence factor. The entire capsule locus of P. multocida A:1 was cloned and sequenced. The locus is divided into three regions. Region 1 comprises four ORFs which are involved in the transport of the capsule polysaccharide to the surface. Region 2 comprises five ORFs whose postulated protein products are involved in the biosynthesis of the polysaccharide capsule. Region 3 comprises two ORFs whose postulated products show similarity to proteins that are involved in the phospholipid substitution of the polysaccharide capsule.
Department of Microbiology, Monash University, Clayton, Vic., Australia.
J Y
JY
Chung
Y
Y
Zhang
B
B
Adler
D000595:Amino Acid Sequence; D016667:Bacterial Capsules / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics*; D002874:Chromosome Mapping; D005798:Genes, Bacterial; D006820:Hyaluronic Acid / Q000096:biosynthesis; D008969:Molecular Sequence Data; D005810:Multigene Family; D016366:Open Reading Frames; D016979:Pasteurella multocida / Q000235:genetics* / Q000378:metabolism / Q000472:pathogenicity; D010957:Plasmids / Q000235:genetics; D011401:Promoter Regions, Genetic; D015183:Restriction Mapping; D017422:Sequence Analysis, DNA; D014774:Virulence
D006820:Hyaluronic Acid