[Two new steroidal saponins from Allium sativum and their inhibitory effects on blood coagulability].
Six compunds were isolated from the fresh bulbs of Allium sativum L (garlic). Their structures were elucidated as proto-iso-eruboside-B (I), eruboside-B (II), iso-eruboside-B (III), sativioside C (IV), adenosine (V) and tryptophan (VI). I and III are new steroidal saponins. This paper deals with the structural determination of I and III and their effects on platelet aggregation, blood coagulation and fibrinolysis in vitro.
Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing, Japan.
J P
JP
Peng
H
H
Chen
Y Q
YQ
Qiao
L R
LR
Ma
T
T
Narui
H
H
Suzuki
T
T
Okuyama
H
H
Kobayashi
D000818:Animals; D000925:Anticoagulants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D005343:Fibrinolytic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005737:Garlic / Q000737:chemistry*; D015394:Molecular Structure; D010946:Plants, Medicinal; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011817:Rabbits; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013256:Steroids; D014315:Triterpenes
D000925:Anticoagulants; D004365:Drugs, Chinese Herbal; D005343:Fibrinolytic Agents; D010975:Platelet Aggregation Inhibitors; D012503:Saponins; D013256:Steroids; D014315:Triterpenes; C115260:proto-iso-eruboside B; C115259:isoeruboside B