Cerebrospinal fluid tau protein is not elevated in HIV-associated neurologic disease in humans. HIV Neurobehavioral Research Center Group (HNRC).
We measured the concentrations of the neuron-specific protein, tau, in the cerebrospinal fluid (CSF) of 32 neurologically characterized HIV-infected (HIVpos) subjects and nine matched seronegative (HIVneg) controls using a sensitive ELISA assay. Of 32 HIVpos subjects, nine had HIV-associated neurocognitive disorders, and nine had clinically diagnosed peripheral neuropathies. CSF tau levels in subjects with HIV-associated neurocognitive disorders were similar to those in HIVneg subjects (185 +/- 83 vs. 223 +/- 106 pg/ml; P = 57). CSF tau levels in HIVpos subjects with peripheral neuropathies did not differ from those without neuropathies (320 +/- 190 vs. 251 +/- 185; P = 23). In summary, CSF tau levels were not elevated in patients with HIV-associated neurologic disease.
Department of Neurosciences, University of California, San Diego, USA. roellis@ucsd.edu
R J
RJ
Ellis
P
P
Seubert
R
R
Motter
D
D
Galasko
R
R
Deutsch
R K
RK
Heaton
M P
MP
Heyes
J A
JA
McCutchan
J H
JH
Atkinson
I
I
Grant
D015526:AIDS Dementia Complex / Q000134:cerebrospinal fluid*; D000328:Adult; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000134:cerebrospinal fluid / Q000150:complications; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000134:cerebrospinal fluid; D011446:Prospective Studies; D016875:tau Proteins / Q000134:cerebrospinal fluid*
D016875:tau Proteins