Skin sensitization and photosensitization studies of hydrophobically modified hydroxypropyl methylcellulose in guinea pigs.
Skin sensitization and photosensitization tests of hydrophobically modified hydroxypropyl methylcellulose (HM-HPMC), a new cellulose derivative used as a thickener for topical pharmaceuticals, were conducted using guinea pigs. An aqueous dispersion of HM-HPMC (3 w/v %) was applied in the tests. Skin reaction was not observed in any animal in the HM-HPMC-treated group or control group. In the photosensitization test, no skin reaction was found in any animal in the test-preparation group or the control group. It was concluded that HM-HPMC dispersion does not exhibit skin sensitizing or photosensitizing activity under the condition of this test.
Specialty Chemicals Research Center, Shin-Etsu Chemical Co., Ltd., Niigata, Japan.
S
S
Obara
K
K
Maruyama
N
N
Ichikawa
O
O
Tanaka
M
M
Ohtsuka
M
M
Kawanabe
Y
Y
Niikura
M
M
Tennichi
A
A
Suzuki
N
N
Hoshino
K
K
Ohwada
D000277:Adjuvants, Pharmaceutic / Q000008:administration & dosage / Q000633:toxicity*; D000287:Administration, Topical; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D065347:Hypromellose Derivatives; D008027:Light / Q000009:adverse effects*; D008747:Methylcellulose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D010787:Photosensitivity Disorders / Q000175:diagnosis; D012867:Skin / Q000187:drug effects*; D012882:Skin Tests; D012995:Solubility
D000277:Adjuvants, Pharmaceutic; D065347:Hypromellose Derivatives; D008747:Methylcellulose