Inducers of the cytochrome P-450 superfamily as promoters of carcinogenesis.
This review summarizes data on the mechanisms of tumor-promoting activity of non-genotoxic compounds that are inducers of cytochrome P-450 isoforms. Their promoting activity is analyzed in term of synthesis of new cytochrome P-450 isoforms. Active oxygen species formed by cytochrome P-450 isoforms can simultaneously act as stimulators of proliferation and inhibitors of intercellular communications. Promoter effects can be associated with changes in the ratio of cellular signaling non-protein molecules induced by newly synthesized cytochrome P-450 isoforms. Data on induction of cytochrome P-450 isoforms of family 1 indicate that inducer interaction with its receptor causes cellular events resulting in the stimulation of cell proliferation.
Institute of Carcinogenesis, Blokhin Oncology Research Center, Russian Academy of Medical Sciences, Moscow, 115478, Russia.
V A
VA
Koblyakov
D000818:Animals; D002273:Carcinogens / Q000494:pharmacology; D002450:Cell Communication / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D004790:Enzyme Induction; D006801:Humans; D007527:Isoenzymes / Q000096:biosynthesis; D009369:Neoplasms / Q000139:chemically induced / Q000473:pathology*
D002273:Carcinogens; D007527:Isoenzymes; D003577:Cytochrome P-450 Enzyme System