Translocation (1;22) in refractory anemia and the prognostic significance of karyotypic abnormalities in refractory anemia.
The most common cytogenetic abnormalities associated with myelodysplastic syndromes are deletions of chromosomes 5 and 7 and trisomy 8. Reciprocal translocation is relatively uncommon in refractory anemia. We describe a case of refractory anemia associated with trisomy 8 and a derivative chromosome 22 resulting from t(1;22)(q11;q11.2). The diseases and the role of the various genes that are mapped to these breakpoints are discussed. The prognostic significance of karyotypic abnormalities in refractory anemia are reviewed.
Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock 79430, USA.
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YK
Keung
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Cobos
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Tonk
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Morgan
D000368:Aged; D000753:Anemia, Refractory / Q000235:genetics*; D002878:Chromosomes, Human, Pair 1; D002892:Chromosomes, Human, Pair 22; D005260:Female; D006801:Humans; D007621:Karyotyping; D011379:Prognosis; D014178:Translocation, Genetic