ICP during anaesthesia with sevoflurane: a dose-response study. Effect of hypocapnia.
In patients with a supratentorial cerebral tumor, an increase in sevoflurane concentration from 1.5% (0.7 MAC) to 2.5% (1.3 MAC) did not change the intracranial pressure (ICP) significantly (12 to 14 mm Hg (medians)). However, a significant increase in cerebral blood flow (CBF) from 29 to 39 ml/100 g/min (medians) was disclosed. During administration of sevoflurane 1.5% and 2.5%, a significant decrease in ICP (3.5 and 3.0 mm Hg (median) respectively) was found when PaCO2 was decreased by 0.8 kPa.
Department of Neuroanaesthesia, Aarhus University Hospital, Denmark.
G E
GE
Cold
H
H
Bundgaard
G
G
von Oettingen
K A
KA
Jensen
U
U
Landsfeldt
K M
KM
Larsen
D000769:Anesthesia, Inhalation; D018685:Anesthetics, Inhalation; D001921:Brain / Q000098:blood supply; D002245:Carbon Dioxide / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D005283:Fentanyl; D006801:Humans; D007427:Intracranial Pressure / Q000187:drug effects*; D008738:Methyl Ethers; D012039:Regional Blood Flow / Q000187:drug effects; D000077149:Sevoflurane; D015173:Supratentorial Neoplasms / Q000601:surgery
D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D002245:Carbon Dioxide; D000077149:Sevoflurane; D005283:Fentanyl