[A rare cause of intra-alveolar hemorrhage: a transfusion-related incident with leukoagglutination due to antigranulocyte antibodies (Trali syndrome)].
BACKGROUND
Transfusion-related acute lung injury (TRALI) is an infrequent but life-threatening complication of hemotherapy, usually secondary to passive transfer of antibody from the donor's plasma to the recipient. TRALI is a diagnosis of exclusion often masked by underlying factors.


METHODS
We report a new case of TRALI in a patient with severe multinevritis associated with Sjögren's syndrome and cryoglobulinemia, who had received intravenous immunoglobulins.


CONCLUSIONS
This case report underlines the difficulty to establish a diagnosis in both acute respiratory failure and intra-alveolar hemorrhage in patients with auto-immune disorders. This case report also emphasizes the necessity of taking precautions in these immunocompromised patients in whom hemoglobin transfusion is required.
Cailleux
N
N
Département de médecine interne, Hôpital de Boisguillaume, CHU, Rouen, France.
Lévesque
H
H
Bastit
D
D
Cuvelier
A
A
Muir
J F
JF
Courtois
H
H
D000368:Aged; D000906:Antibodies / Q000009:adverse effects*; D003449:Cryoglobulinemia / Q000628:therapy; D004903:Erythrocyte Aggregation / Q000209:etiology; D017707:Erythrocyte Transfusion / Q000009:adverse effects*; D005260:Female; D006098:Granulocytes / Q000276:immunology*; D006469:Hemoptysis / Q000209:etiology*; D006801:Humans; D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D011115:Polyneuropathies / Q000628:therapy; D011650:Pulmonary Alveoli / Q000473:pathology*; D012128:Respiratory Distress Syndrome / Q000209:etiology*; D012859:Sjogren's Syndrome / Q000628:therapy
D000906:Antibodies; D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains; D016756:Immunoglobulins, Intravenous
Une cause rare d'hémorragie intra-alvéolaire: l'accident transfusionnel avec leucoagglutination par anticorps antigranuleux (syndrome Trali).