Toxicity of methomyl following intravenous administration in the horse.
Methomyl (S-methyl-N-((methylcarbamoyl)oxy) thioacetimidate) toxicity was studied in horses using i.v. dosages from 0.01 to 3.0 mg/kg. Doses of 1-3 mg methomyl/kg produced increased GI motility and respirations, facial fasiculations, salivation, lacrimation and convulsions. The only effect at 0.5 mg/kg was increased GI sounds in 1/4 horses. This extensively used crop insecticide had been associated with episodes of morbidity and mortality and led to speculation that it was extremely potent to the horse. This was not supported by these clinical studies.
Department of Entomology, University of California, Riverside 92521, USA.
R I
RI
Krieger
P
P
South
A
A
Mendez Trigo
I
I
Flores
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006734:Horse Diseases / Q000139:chemically induced*; D006736:Horses; D007275:Injections, Intravenous; D007306:Insecticides / Q000506:poisoning*; D008724:Methomyl / Q000506:poisoning*; D011041:Poisoning / Q000662:veterinary
D007306:Insecticides; D008724:Methomyl