Transcriptional control: repression by local chromatin modification.
It is becoming increasingly clear that chromatin modification plays a fundamental part in transcriptional control. Recent studies provide new insights into how transcriptional repressors, in addition to blocking activators, may recruit repression complexes that include chromatin modification factors.
Ashraf
S I
SI
Program in Molecular Medicine, University of Massachusetts Medical Center, Worcester 01605, USA.
Ip
Y T
YT
D000429:Alcohol Oxidoreductases; D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D002453:Cell Cycle / Q000502:physiology; D002843:Chromatin / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D002868:Chromosomal Proteins, Non-Histone; D018899:CpG Islands; D019175:DNA Methylation; D004268:DNA-Binding Proteins / Q000502:physiology*; D004331:Drosophila melanogaster / Q000235:genetics / Q000502:physiology; D005786:Gene Expression Regulation / Q000502:physiology*; D006655:Histone Deacetylases; D006801:Humans; D051783:Methyl-CpG-Binding Protein 2; D008957:Models, Genetic; D010750:Phosphoproteins / Q000502:physiology; D011506:Proteins / Q000502:physiology; D012097:Repressor Proteins / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic / Q000502:physiology*; D016335:Zinc Fingers / Q000502:physiology
D000429:Alcohol Oxidoreductases; D051792:Basic Helix-Loop-Helix Proteins; D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D006655:Histone Deacetylases; D051783:Methyl-CpG-Binding Protein 2; D010750:Phosphoproteins; D011506:Proteins; D012097:Repressor Proteins; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; C497392:MECP2 protein, human; C489689:MeCP1 histone deacetylase complex, human; C071731:SIN3 protein, S cerevisiae; C091023:gro protein, Drosophila; C096794:C-terminal binding protein