Depletion of penicillin G residues in tissues, plasma and injection sites of market pigs injected intramuscularly with procaine penicillin G.
Procaine penicillin G was administered by intramuscular (i.m.) injection to groups of healthy 100 kg market pigs at the approved label dose (15,000 IU/kg body weight), once daily for three consecutive days; or an extra-label dose (66,000 IU/kg body weight), once daily for five consecutive days. Penicillin G residue depletion was followed in plasma, tissue and injection sites using a liquid chromatographic method. Groups of pigs were killed 1, 2, 3, 4, 5 and 8 days after the last injection with the label dose. Penicillin G was not detected in liver after 1 day of withdrawal, in muscle and fat after 2 days of withdrawal, in plasma after 4 days of withdrawal, in skin after 5 days of withdrawal, or in kidney and the injection sites after 8 days of withdrawal. Other groups of pigs were killed 1, 2, 3, 5 and 7 days after injection with the extra-label dose. In these pigs penicillin G was not found in liver after 2 days of withdrawal, in fat after 3 days of withdrawal, or in the muscle, skin, plasma and injection sites after 7 days of withdrawal. Penicillin G was found at all times in the kidneys of the groups of pigs that received the high dose. The technique used for neck injections was critical to obtain intramuscular rather than intermuscular injections. The Bureau of Veterinary Drugs, Health Protection Branch, Health Canada calculated that the appropriate withdrawal period for pigs was 8 days for a dose of 15,000 IU procaine penicillin G/kg body weight and 15 days for a dose of 66,000 IU/kg.
Centre for Veterinary Drug Residues, Canadian Food Inspection Agency, Health of Animals Laboratory, Saskatoon, Saskatchewan, Canada.
G O
GO
Korsrud
C D
CD
Salisbury
C S
CS
Rhodes
M G
MG
Papich
W D
WD
Yates
W S
WS
Bulmer
J D
JD
MacNeil
D A
DA
Landry
G
G
Lambert
M S
MS
Yong
L
L
Ritters
D000273:Adipose Tissue / Q000737:chemistry; D000818:Animals; D002853:Chromatography, Liquid; D004350:Drug Residues; D005506:Food Contamination / Q000032:analysis*; D007273:Injections, Intramuscular; D007668:Kidney / Q000737:chemistry; D008099:Liver / Q000737:chemistry; D008460:Meat; D018482:Muscle, Skeletal / Q000737:chemistry; D010400:Penicillin G / Q000008:administration & dosage / Q000032:analysis* / Q000097:blood; D010406:Penicillins / Q000008:administration & dosage / Q000032:analysis* / Q000097:blood; D012867:Skin / Q000737:chemistry; D013552:Swine; D013997:Time Factors
D010406:Penicillins; D010400:Penicillin G