Importance of immunological and inflammatory processes in the pathogenesis and therapy of Alzheimer's disease.
The contribution of autoimmune processes or inflammatory components in the etiology and pathogenesis of Alzheimer's disease (AD) has been suspected for many years. The presence of antigen-presenting, HLA-DR-positive and other immunoregulatory cells, components of complement, inflammatory cytokines and acute phase reactants have been established in tissue of AD neuropathology. Although these data do not confirm the immune response as a primary cause of AD, they indicate involvement of immune processes at least as a secondary or tertiary reaction to the preexisting pathogen and point out its driving-force role in AD pathogenesis. These processes may contribute to systemic immune response. Thus, experimental and clinical studies indicate impairments in both humoral and cellular immunity in an animal model of AD as well as in AD patients. On the other hand, anti-inflammatory drugs applied for the treatment of some chronic inflammatory diseases have been shown to reduce risk of AD in these patients. Therefore, it seems that anti-inflammatory drugs and other substances which can control the activity of immunocompetent cells and the level of endogenous immune response can be valuable in the treatment of AD patients.
Departamento de Ciencias Morfológicas y Psicobiología, Facultad de Medicina, Universidad de Murcia, Espinardo, Spain.
M
M
Popović
M
M
Caballero-Bleda
L
L
Puelles
N
N
Popović
D000209:Acute-Phase Proteins / Q000378:metabolism; D000544:Alzheimer Disease / Q000209:etiology / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control / Q000628:therapy; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D017209:Apoptosis; D001323:Autoantibodies / Q000276:immunology; D015551:Autoimmunity; D001921:Brain / Q000276:immunology / Q000473:pathology; D002118:Calcium / Q000378:metabolism; D003165:Complement System Proteins / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D010450:Endopeptidases / Q000378:metabolism; D018698:Glutamic Acid / Q000502:physiology; D006801:Humans; D007111:Immunity, Cellular; D007249:Inflammation; D017136:Ion Transport; D017628:Microglia / Q000276:immunology; D008954:Models, Biological; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009498:Neurotoxins / Q000378:metabolism; D051381:Rats
D000209:Acute-Phase Proteins; D016229:Amyloid beta-Peptides; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001323:Autoantibodies; D016207:Cytokines; D009419:Nerve Tissue Proteins; D009498:Neurotoxins; D018698:Glutamic Acid; D003165:Complement System Proteins; D010450:Endopeptidases; D002118:Calcium