A more versatile and reliable method for renal transplantation in the rat.
This study describes the authors' experience with a new method of orthotopic renal transplantation in the rat. This technique combines previously described modifications with the use of the donor inferior vena cava as a conduit to perform an end-to-side venous anastomosis. Survival was 87% and 80% at 3 and 120 days, respectively. Patency was 80% at 120 days, and histologic examination revealed normal renal architecture and parenchyma, with no evidence of ischemic injury. This technique offers a refinement of previous techniques and is reliable, flexible, and can be easily learned by novice microvascular surgeons.
Department of Surgery, University of Rochester School of Medicine and Dentistry, NY 14642, USA.
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D
Blom
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MS
Orloff
D000714:Anastomosis, Surgical; D000818:Animals; D007668:Kidney / Q000033:anatomy & histology; D016030:Kidney Transplantation / Q000379:methods*; D008297:Male; D008866:Microsurgery / Q000379:methods; D051381:Rats; D011916:Rats, Inbred F344; D011917:Rats, Inbred Lew; D014184:Transplantation, Homologous; D014654:Vascular Patency; D014682:Vena Cava, Inferior / Q000637:transplantation