Hemostatic efficacy of a fibrin sealant dressing in an animal model of kidney injury.
OBJECTIVE
The purpose of this study is to determine the hemostatic efficacy of a fibrin sealant dressing compared with a standard collagen control dressing in an animal model of kidney injury.


METHODS
Twenty adult male Sprague-Dawley rats were administered general anesthesia and underwent partial nephrectomy with heparin anticoagulation (300 U/kg intravenous). Treatment of the cut surface of the kidney was randomized to three groups: group I, no hemostatic agent; group II, collagen dressing; and group III, fibrin sealant dressing.


RESULTS
Blood loss was significantly less in group III (3.39+/-0.63 mL) than in group I (8.64+/-2.26 mL) and group II (8.63+/-1.72 mL; p < 0.001). The percentage decrease in the mean arterial pressure was significantly less in group III (34.09+/-15.58%) than in group I (59.66+/-16.19%) and group II (60.35+/-15.66%; p=0.015).


CONCLUSIONS
Fibrin sealant dressings provide effective hemostasis and are superior to collagen dressings in an animal model of kidney injury. Additional development of fibrin sealant dressings for potential clinical use is warranted.
Department of Surgery, University of Texas Southwestern Medical Center, Dallas 75235-9157, USA. mrjacksn@flash.net
M R
MR
Jackson
M M
MM
Taher
J R
JR
Burge
C
C
Krishnamurti
T J
TJ
Reid
B M
BM
Alving
D000818:Animals; D003094:Collagen / Q000627:therapeutic use; D004195:Disease Models, Animal; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D006489:Hemostatic Techniques; D006490:Hemostatics / Q000627:therapeutic use*; D007668:Kidney / Q000293:injuries*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D015718:Fibrin Tissue Adhesive; D006490:Hemostatics; D003094:Collagen