Bifocal sclerosing osteosarcoma: unusual presentation and course.
Multifocal osteosarcoma is uncommon. Long-term survival of an incompletely treated case is exceptional. We report an unusual case of bifocal sclerosing osteosarcoma in a 38-year-old women that involved the left ilium and right proximal femur. The femoral lesion was resected. The tumor in the left ilium was not treated. She did not receive chemotherapy and has been free of metastases for 7 years. Recently, growth of the pelvic osteosarcoma has resulted in vascular compression and edema of the lower extremity. The patient's alkaline phosphatase has been elevated throughout. The tumor was HMB-45 positive, which has not been previously reported in osteosarcoma. The pathogenesis of multifocal osteosarcoma is discussed.
Department of Pathology and Laboratory Medicine, Hospital for Joint Diseases, New York, NY 10009, USA.
L
L
Abramovici
G C
GC
Steiner
Z
Z
Rosenberg
S
S
Kenan
D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000601:surgery; D003952:Diagnostic Imaging; D005260:Female; D005266:Femoral Neoplasms / Q000175:diagnosis* / Q000601:surgery; D005270:Femur Head / Q000473:pathology; D006801:Humans; D007085:Ilium / Q000473:pathology; D012516:Osteosarcoma / Q000175:diagnosis* / Q000601:surgery
D000469:Alkaline Phosphatase