The management of metformin overdose.
Only two cases of deliberate self-poisoning with metformin have been described in the literature. We report the management of three cases, all of which presented with severe lactic acidosis. Two cases had a fatal outcome. The options for treatment and previous cases reported in the literature are reviewed. Recommendations for the management of metformin overdose include early recognition, intensive support of the cardiovascular system, the correction of metabolic acidosis and the maintenance of body temperature. The use of venovenous haemofiltration against a non-lactate containing fluid may improve outcome when sodium bicarbonate alone fails to reverse severe systemic acidosis.
Department of Anaesthesia, Manchester Royal Infirmary, UK.
K F
KF
Teale
A
A
Devine
H
H
Stewart
N J
NJ
Harper
D000140:Acidosis, Lactic / Q000139:chemically induced*; D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D062787:Drug Overdose / Q000628:therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000506:poisoning*; D008297:Male; D008687:Metformin / Q000506:poisoning*; D008875:Middle Aged
D007004:Hypoglycemic Agents; D008687:Metformin