A pyranocoumarin and two alkaloids (one with antispasmodic effect) from Citrus deliciosa.
One pyranocoumarin (xanthyletin, 1) and two acridone alkaloids (2',2'-dimethyl-(pyrano5',6':3:4)-1,5-dihydroxy, 6-methoxy, 10-methylacridone, 3, and citpressine-I, 4), were isolated from the roots of Citrus deliciosa Ten (Rutacea). Their structures were elucidated by spectroscopic methods. Reported 13C NMR assignments of alkaloid 3 have been corrected and those of alkaloid 4 are reported for the first time Alkaloid 3 was found to have antispasmodic effect on isolated ileum segments excised from male rabbits.
Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Egypt.
A M
AM
el-Shafae
A S
AS
Soliman
D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D002957:Citrus / Q000737:chemistry*; D003374:Coumarins / Q000302:isolation & purification* / Q000494:pharmacology*; D066298:In Vitro Techniques; D007422:Intestines / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010276:Parasympatholytics / Q000302:isolation & purification* / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D011817:Rabbits; D013056:Spectrophotometry, Ultraviolet
D000470:Alkaloids; D003374:Coumarins; D010276:Parasympatholytics