Hyperpigmentation due to topical calcipotriol and photochemotherapy in two psoriatic patients.
The vitamin D3 analogue calcipotriol (calcipotriene) is an effective topical treatment for psoriasis. In combination with other antipsoriatic agents, such as ultraviolet radiation, calcipotriol is reported to improve the overall efficacy of the treatment. Here we describe two patients treated with a combination treatment of calcipotriol and bath psoralens and ultraviolet A who developed hyperpigmentation at the lesional sites where calcipotriol ointment was applied.
Department of Dermatology, University of Kiel, Germany.
R
R
Gläser
J
J
Röwert
U
U
Mrowietz
D000328:Adult; D002117:Calcitriol / Q000009:adverse effects / Q000031:analogs & derivatives*; D003879:Dermatologic Agents / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D017495:Hyperpigmentation / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy / Q000009:adverse effects*; D011565:Psoriasis / Q000188:drug therapy
D003879:Dermatologic Agents; C055085:calcipotriene; D002117:Calcitriol