The role of subunit interfaces for the nicotinic acetylcholine receptor's allosterism.
Cross-linking of nicotinic acetylcholine receptors, combined with binding studies and patch-clamp electrophysiology, has proven the existence of a 'pre-existing equilibrium' of functional states and the functional role of subunit interfaces, two key postulates of the allosteric model.
Hucho
F
F
Freie Universität Berlin, Institut für Biochemie, Germany.
Methfessel
C
C
Watty
A
A
D000494:Allosteric Regulation; D000495:Allosteric Site; D000818:Animals; D002462:Cell Membrane / Q000502:physiology; D003432:Cross-Linking Reagents / Q000494:pharmacology; D004120:Dimethyl Suberimidate / Q000494:pharmacology; D004557:Electric Organ / Q000502:physiology; D007700:Kinetics; D046911:Macromolecular Substances; D008956:Models, Chemical; D011978:Receptors, Nicotinic / Q000737:chemistry* / Q000378:metabolism*; D014101:Torpedo
D003432:Cross-Linking Reagents; D046911:Macromolecular Substances; D011978:Receptors, Nicotinic; D004120:Dimethyl Suberimidate