Urinary metabolites of daidzin orally administered in rats.
In a study on the metabolism of flavonoids, the isoflavone glycoside daidzin was orally administered to rats. Urine samples were collected and treated with beta-glucuronidase and arylsulfatase. Aglycone daidzein (M3) and other three metabolites, 3',4',7-trihydroxyisoflavone (M1), 4',7-dihydroxyisoflavanone (M2) and 4',7-dihydroxyisoflavan (M4) were isolated from the urine following treatment with enzymes. The structures of M1, M2 and M4 were determined on the basis of chemical and spectral data.
Yasuda
T
T
Tohoku College of Pharmacy, Sendai, Miyagi, Japan.
Ohsawa
K
K
D000284:Administration, Oral; D000818:Animals; D001192:Arylsulfatases / Q000378:metabolism / Q000494:pharmacology; D002839:Chromans / Q000652:urine; D002851:Chromatography, High Pressure Liquid; D060754:Equol; D005966:Glucuronidase / Q000378:metabolism / Q000494:pharmacology; D007529:Isoflavones / Q000652:urine*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
C007610:4',7-dihydroxy-3,4-dihydroisoflavone; D002839:Chromans; D007529:Isoflavones; C013908:daidzin; D060754:Equol; C004742:daidzein; D001192:Arylsulfatases; D005966:Glucuronidase; C061213:3',4',7-trihydroxyisoflavone