Evaluation of renal hemodynamics in awake and isoflurane-anesthetized cats with pulsed-wave Doppler and quantitative renal scintigraphy.
The feasibility and reproducibility of obtaining the pulsed-wave Doppler measurements of resistive index (RI) and pulsatility index (PI) were investigated in intrarenal arteries of normal, nonsedated cats, and cats anesthetized with isoflurane. In addition, relative renal function and relative renal blood flow were evaluated using quantitative renal scintigraphy. The percentage of injected dose uptake, time to peak activity, and two indices of renal blood flow (K/A ratio and flow index) obtained during the first pass of 99mTc-MAG3, were determined for both awake and anesthetized cats. Results indicate that measuring RI and PI in nonsedated cats is readily accomplished and that the results are reproducible within an animal. Mean RI and PI values in the awake cats were 0.55 and 0.8, respectively. Significant differences between the awake and anesthetized cats were found for all pulsed-wave Doppler and quantitative renal scintigraphic measurements evaluated.
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville 37901-1071, USA.
S K
SK
Mitchell
R L
RL
Toal
G B
GB
Daniel
B W
BW
Rohrbach
D000769:Anesthesia, Inhalation; D018685:Anesthetics, Inhalation / Q000494:pharmacology; D000818:Animals; D001783:Blood Flow Velocity; D002415:Cats; D005069:Evaluation Studies as Topic; D005260:Female; D007530:Isoflurane / Q000494:pharmacology; D007668:Kidney / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000502:physiology; D008297:Male; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012077:Renal Artery / Q000000981:diagnostic imaging* / Q000502:physiology; D012079:Renal Circulation; D015203:Reproducibility of Results; D017263:Technetium Tc 99m Mertiatide; D018617:Ultrasonography, Doppler, Pulsed; D014655:Vascular Resistance / Q000187:drug effects
D018685:Anesthetics, Inhalation; D019275:Radiopharmaceuticals; D017263:Technetium Tc 99m Mertiatide; D007530:Isoflurane