[Synthesis and pharmacologic study of 1,5-benzodiazepine-2,4-diones and their alkyl derivatives].
From the pharmacodynamic studies of 1,5-benzodiazepin-2,4-diones and alkyl derivatives prepared in our laboratories, we can conclude that these products are not toxic at therapeutic dosage. They have sedative, myorelaxant and anxiolytic actions. The two products alkylated by allyl bromide have also hypnotic, sedative and anticonvulsant properties.
Laboratoire de Pharmacologie et de Toxicologie, Faculté de Médecine et de Pharmacie, Rabat Instituts, Maroc.
A
A
Zellou
Y
Y
Cherrah
M
M
Hassar
E M
EM
Essassi
D000478:Alkylation; D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001569:Benzodiazepines; D006993:Hypnotics and Sedatives / Q000138:chemical synthesis / Q000494:pharmacology; D051379:Mice; D009125:Muscle Relaxants, Central / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D014151:Anti-Anxiety Agents; D006993:Hypnotics and Sedatives; D009125:Muscle Relaxants, Central; D001569:Benzodiazepines
Synthèse et étude pharmacologique des 1,5-benzodiazépine-2,4-diones et de leurs dérivés alkylés.