Vascular control of nutrient delivery by flow redistribution within muscle: implications for exercise and post-exercise muscle metabolism.
There is evidence for non-nutritive flow routes within, or associated with, skeletal muscle. Large capillary-like structures are possible candidates. The proportion of flow distributed between nutritive and non-nutritive routes appears to be tightly regulated and can control muscle metabolism and contraction by regulating delivery and product removal. The portion of flow that is carried by the non-nutritive routes at rest affords a flow reserve for amplifying nutrient delivery as muscle begins to work and may determine post-exercise metabolism. Inappropriate signals, however, may diminish nutritive flow to the detriment of muscle performance and post-exercise recovery. New technologies should allow the identification of the non-nutritive routes.
Clark
M G
MG
Division of Biochemistry, Medical School, University of Tasmania, Hobart, Australia.
Rattigan
S
S
Newman
J M
JM
Eldershaw
T P
TP
D002196:Capillaries / Q000502:physiology; D002199:Capillary Permeability / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D008833:Microcirculation / Q000502:physiology; D009119:Muscle Contraction / Q000502:physiology; D018482:Muscle, Skeletal / Q000098:blood supply* / Q000378:metabolism; D010101:Oxygen Consumption / Q000502:physiology; D005082:Physical Exertion / Q000502:physiology*; D012039:Regional Blood Flow / Q000502:physiology; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology
D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents