Cerebral accumulation of beta-amyloid following ischemic brain injury with long-term survival.
Deposits that are recognized by antibodies specific for the C-terminal and beta-amyloid peptide (beta A) but not the N-terminal sequences of the amyloid precursor protein (APP) fragments are present in the extra- and intracellular space in ischemic rat brain with 1 year survival. The immunohistochemical profile indicates that the APP in these deposits is truncated between the N-terminal and beta A and terminates at the C-terminal. This process probably is reaching into the extracellular space.
Pluta
R
R
Department of Neuropathology, Polish Academy of Sciences, Warsaw, Poland.
Barcikowska
M
M
Mossakowski
M J
MJ
Zelman
I
I
D000544:Alzheimer Disease / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000473:pathology; D005260:Female; D006801:Humans; D002534:Hypoxia, Brain / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar
D016229:Amyloid beta-Peptides