Benzodiazepine binding site-interactive flavones from Scutellaria baicalensis root.
A benzodiazepine binding assay directed separation led to the identification of 3 flavones baicalein (1), oroxylin A (2), and skullcapflavone II (3) from the water extract of Scutellaria baicalensis root. Compounds 1, 2, and 3 interacted with the benzodiazepine binding site of GABAA receptors with a Ki value of 13.1, 14.6 and 0.36 micromol/L, respectively.
Liao
J F
JF
Department of Pharmacology, National Yang-Ming University, Taipei, Taiwan, Republic of China.
Wang
H H
HH
Chen
M C
MC
Chen
C C
CC
Chen
C F
CF
D000818:Animals; D001667:Binding, Competitive; D002462:Cell Membrane / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005445:Flunitrazepam / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D015394:Molecular Structure; D018517:Plant Roots; D010946:Plants, Medicinal; D011963:Receptors, GABA-A / Q000378:metabolism*
D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D011963:Receptors, GABA-A; D005445:Flunitrazepam