Effect of two types of fish oil supplementation on plasma and erythrocyte phospholipids in formula-fed term infants.
We studied the effect of docosahexaenoic acid (DHA) supplementation of infant formulas on fatty acid composition of blood phospholipids in term infants. Two fish oil supplemented formulas containing 0.45 wt% DHA and high (0.35%) or low (0.10%) eicosapentaenoic acid (EPA) were fed for 42 days and compared with a standard formula and breast milk. Infants fed supplemented formulas and breast milk had similar time-dependent changes for DHA from birth to day 42, i.e., slight decreases in plasma phospholipids and erythrocyte phosphatidylcholine and no change in erythrocyte phosphatidylethanolamine. Low-EPA formula prevented EPA accumulation but did not limit the significant decrease in arachidonic acid (AA) noted in infants fed high-EPA formula. These results suggest that term infant formulas should be supplemented with DHA-rich EPA, low fish oil and AA to achieve a fatty acid status in formula-fed infants similar to that of breast-fed infants.
Maurage
C
C
Equipe Associée, Université de Tours EA2103-INRA, Laboratoire de Nutrition et Securité Alimentaire, Jouy-en-Josas, France.
Guesnet
P
P
Pinault
M
M
Rochette de Lempdes
J
J
Durand
G
G
Antoine
J
J
Couet
C
C
D016718:Arachidonic Acid / Q000008:administration & dosage; D019587:Dietary Supplements; D004281:Docosahexaenoic Acids / Q000008:administration & dosage; D015118:Eicosapentaenoic Acid / Q000008:administration & dosage; D004912:Erythrocytes / Q000378:metabolism*; D005227:Fatty Acids / Q000097:blood; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage; D005395:Fish Oils / Q000008:administration & dosage*; D005865:Gestational Age; D006128:Growth; D006801:Humans; D007225:Infant Food; D007231:Infant, Newborn; D010743:Phospholipids / Q000097:blood*; D014810:Vitamin E / Q000097:blood
D005227:Fatty Acids; D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D010743:Phospholipids; D014810:Vitamin E; D004281:Docosahexaenoic Acids; D016718:Arachidonic Acid; D015118:Eicosapentaenoic Acid