[Physiologic activation of peroxidation by negative air ions].
The effect of negative air ions (NAI) was investigated on physiological processes of peroxidative oxidation in mitochondria preserving their native structure organization in associations in rat liver homogenate. Tchijevsky lustre generating superoxide was served as a source of NAI. The investigated objects were put into solutions pretreated with NAI flow. An increase of peroxide induced Ca2+ release from mitochondria loaded with the cation was found. Under prolonged action of NAI flow on homogenates kept in ice followed by incubation in media pretreated with NAI an elevation of products of peroxide lipid oxidation (POL) was found in case of their low initial level and decrease of POL products in case of their high initial level. The range of changes is considerably less than under pathogeneous rise of POL. The discovered mild activation of peroxidative oxidation within physiological range of POL concentrations is considered as a primary physico-chemical mechanism of beneficial biological action of NAI.
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
I R
IR
Saakian
V G
VG
Gogvadze
T V
TV
Sirota
I G
IG
Stavrovskaia
M N
MN
Kondrashova
D000388:Air; D000818:Animals; D000838:Anions; D002118:Calcium / Q000378:metabolism; D004837:Epinephrine / Q000008:administration & dosage; D015227:Lipid Peroxidation; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D000838:Anions; D002118:Calcium; D004837:Epinephrine
Fiziologicheskaia aktivatsiia perekisnogo okisleniia otritsatel'nymi aéroionami.