Effects of ion channel activity on development of dorsal root ganglion neurons.
Studies of mouse dorsal root ganglion neurons in vitro demonstrate that ion channel function and regulation can influence a wide range of developmental processes. The work suggests that much as exposure to different trophic factors, the pattern of impulse activity a neuron experiences can have significant structural and functional effects during development. Studies concerning effects of ion channel activity on growth cone motility, axon fasciculation, synaptic plasticity, myelination, and intracellular signaling pathways regulating gene expression are presented in the context of changes in endogenous firing patterns during development.
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Laboratory of Developmental Neurobiology, National Institutes of Health, NICHD, Bethesda, Maryland 20892, USA.
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D015220:Calcium Channels / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000378:metabolism; D005071:Evoked Potentials / Q000502:physiology; D005727:Ganglia, Spinal / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D020439:Growth Cones / Q000378:metabolism; D051379:Mice; D009473:Neuronal Plasticity; D009475:Neurons, Afferent / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism*
D015220:Calcium Channels; D015815:Cell Adhesion Molecules