[The pharmacological regulation of thrombocyte activity].
Among the main means of producing a pharmacological effect on the functional activity of blood platelets are blockade of the specific membrane receptors, inhibition of the activity of the enzymes cyclooxygenase and thromboxane synthetase, increase in the cell cAMP and cGMP content. The intracellular level of free calcium constants is the main link in platelet activity regulation. A classification of antithrombocytic compounds based on the main site of their action is suggested. The effectiveness of drugs affecting the initial and final stages of the cascade mechanism of platelet activation is substantiated.
Dukhanin
A S
AS
Russian State Medical University, Moscow, Russia.
Gubaeva
F R
FR
D000818:Animals; D003864:Depression, Chemical; D006801:Humans; D015539:Platelet Activation / Q000187:drug effects* / Q000502:physiology; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000502:physiology; D013268:Stimulation, Chemical
D010975:Platelet Aggregation Inhibitors; D011956:Receptors, Cell Surface
Farmakologicheskaia reguliatsiia aktivnosti trombotsitov.