Importance of atypical glandular cells of uncertain significance in cervical cytologic smears.
OBJECTIVE
To determine the clinical implications of atypical glandular cells of uncertain significance (AGCUS) in cervical cytologic smears.


METHODS
Retrospective analysis.


RESULTS
Eighty-eight of 32,181 (0.27%) cervical smears obtained during the study period contained AGCUS. Of the 47 women with AGCUS, 16 had intraepithelial or invasive neoplasms (34%; 95% confidence interval, 21-49%), including 9 low or high grade squamous intraepithelial lesions, 1 adenocarcinoma in situ of the cervix, 3 adenocarcinomas of the cervix, 2 adenocarcinomas of the endometrium and 1 adenoid basal cell carcinoma of the cervix.


CONCLUSIONS
The high prevalence of cervical and endometrial neoplasia among women with the isolated finding of AGCUS on cervical cytologic smears warrants a thorough diagnostic evaluation.
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, USA. abner@ob.ucsf.edu
A P
AP
Korn
P L
PL
Judson
C J
CJ
Zaloudek
D000293:Adolescent; D000328:Adult; D000368:Aged; D002584:Cervix Uteri / Q000473:pathology*; D016889:Endometrial Neoplasms / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008403:Mass Screening; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis*; D014626:Vaginal Smears