Molecular clusters in water protein solutions in the presence of heavy metal ions.
For the first time, formation of macromolecular protein clusters in the presence of heavy metal ions were observed by the light scattering method. Conditions of the formation and destruction of such clusters were investigated. The clusters mass has a maximum value at the isoelectric point of the protein and increases with the ionic strength of the solution. Formation of clusters in the presence of toxic heavy metals in living cells is believed to have an essential physiological meaning. The molecular mechanisms of such clusters formation are discussed.
Petrova
G P
GP
Moscow State University, Faculty of Physics, Department of Molecular Physics, Russia.
Petrusevich YuM
Evseevicheva
A N
AN
D055592:Biophysical Phenomena; D001703:Biophysics; D006801:Humans; D066298:In Vitro Techniques; D007477:Ions; D007526:Isoelectric Point; D007768:Lactalbumin / Q000737:chemistry; D008027:Light; D046911:Macromolecular Substances; D019216:Metals, Heavy / Q000737:chemistry*; D009994:Osmolar Concentration; D010047:Ovalbumin / Q000737:chemistry; D011506:Proteins / Q000737:chemistry*; D012542:Scattering, Radiation; D012709:Serum Albumin / Q000737:chemistry; D012996:Solutions; D055672:Static Electricity; D013816:Thermodynamics; D014867:Water
D007477:Ions; D046911:Macromolecular Substances; D019216:Metals, Heavy; D011506:Proteins; D012709:Serum Albumin; D012996:Solutions; D014867:Water; D010047:Ovalbumin; D007768:Lactalbumin