Gabapentin. Antiepileptic mechanism of action.
Gabapentin is an antiepileptic drug used in the treatment of partial and generalized tonic-clonic seizures. Its antiepileptic mechanism of action is not known. The transport of gabapentin across membranes and its demonstrated effects on voltage-gated ion channels (sodium, calcium), presynaptic mechanisms that can enhance GABAergic inhibition, and ligand-gated ion channels (GABA receptors and glutamate receptors) are reviewed.
Kelly
K M
KM
Center for Neurosciences Research, Allegheny University of the Health Sciences Pittsburgh, PA 15212-4772, USA.
D000085:Acetates / Q000494:pharmacology*; D000200:Action Potentials / Q000187:drug effects; D000588:Amines; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D015220:Calcium Channels / Q000187:drug effects; D003509:Cyclohexanecarboxylic Acids; D004827:Epilepsy / Q000188:drug therapy*; D000077206:Gabapentin; D006801:Humans; D015640:Ion Channel Gating / Q000187:drug effects; D009433:Neural Inhibition / Q000187:drug effects; D018079:Receptors, GABA / Q000187:drug effects; D017470:Receptors, Glutamate / Q000187:drug effects; D015222:Sodium Channels / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000187:drug effects
D000085:Acetates; D000588:Amines; D000927:Anticonvulsants; D015220:Calcium Channels; D003509:Cyclohexanecarboxylic Acids; D018079:Receptors, GABA; D017470:Receptors, Glutamate; D015222:Sodium Channels; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin