Effects of weaning and restraint stress on glucocorticoid receptor binding capacity in limbic areas of domestic pigs.
Changes in glucocorticoid receptor (GR) binding in different brain areas were investigated in neonatal and adult pigs exposed to psychological stress (weaning) and a physical stressor (repeated snaring). The GR binding was significantly decreased 4 days after weaning in both the hippocampus and the amygdala, but there were no changes in the hypothalamus. Repeated snaring of adult pigs resulted in a significant diminished GR binding only in the hippocampus.
Kanitz
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Department of Physiological Principles in Animal Behaviour, Research Institute for the Biology of Farm Animals, Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany. ekanitz@fbn-dummerstrof.de
Manteuffel
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Otten
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W
D000818:Animals; D000831:Animals, Newborn; D006854:Hydrocortisone / Q000097:blood; D007700:Kinetics; D008032:Limbic System / Q000502:physiology*; D011965:Receptors, Glucocorticoid / Q000502:physiology*; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000378:metabolism*; D013552:Swine; D014886:Weaning
D011965:Receptors, Glucocorticoid; D006854:Hydrocortisone