Long-term follow-up of severe central serous chorioretinopathy using indocyanine green angiography.
BACKGROUND
The severe types of central serous chorioretinopathy (CSC) have a chronic nature, suggesting that a pathological process persists subclinically. Indocyanine green (ICG) angiography recently revealed intrachoroidal dye leakage and its static nature in CSC. As the intrachoroidal dye leakage was suspected to be relevant to the disease process, the long-term persistence of intrachoroidal ICG leakage was examined in four patients of the severe types of CSC.


METHODS
ICG angiography was performed periodically over more than three years in three patients and two years in one patient. One patient had CSC with bullous retinal detachment, and the other three had chronic CSC or diffuse retinal pigment epitheliopathy.


RESULTS
Intrachoroidal ICG leakage persisted in all the patients. However, a change in location of persistent intrachoroidal leakage or disappearance of intrachoroidal leakage regardless of no progression of retinal pigment epithelial alteration was noted in one eye of two patients.


CONCLUSIONS
Pathology causing intrachoroidal ICG leakage persisted subclinically for a long period. However, location and extent of the intrachoroidal leakage could change during a long-term follow-up period.
Department of Ophthalmology, Osaka City University Medical School, Osaka, Japan.
K
K
Shiraki
M
M
Moriwaki
M
M
Matsumoto
N
N
Yanagihara
T
T
Yasunari
T
T
Miki
D000328:Adult; D002199:Capillary Permeability; D015862:Choroid Diseases / Q000150:complications / Q000473:pathology*; D005122:Exudates and Transudates; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D008875:Middle Aged; D010857:Pigment Epithelium of Eye / Q000473:pathology; D012163:Retinal Detachment / Q000150:complications; D012164:Retinal Diseases / Q000150:complications / Q000473:pathology*
D007208:Indocyanine Green