Seminal androgen concentrations and residual sperm cytoplasm.
To explore a possible link between seminal androgen concentrations and residual sperm cytoplasm, which constitutes one of the cytological anomalies of the spermatozoon middle piece, testosterone (T), delta4-androstenedione, the precursor of T during testicular androgen biosynthesis and the active metabolite of T, dihydrotestosterone, were assayed in the seminal fluid of 37 patients. A statistically significant correlation was found by linear regression (r = +0.380, P = 0.020, y = 0.02x + 0.45) between seminal T concentrations and the percentage of spermatozoa with a residual cytoplasmic droplet. Given the impact on fertility of residual sperm cytoplasm, assessment of seminal T concentrations could provide useful information on the fertility status of patients.
Laboratoire de Biochimie-Biologie de la Reproduction, Centre Hospitalier Général, Chartes, France.
A
A
Laudat
J
J
Guechot
A M
AM
Palluel
D000328:Adult; D000728:Androgens / Q000032:analysis*; D000735:Androstenedione / Q000032:analysis; D003593:Cytoplasm / Q000737:chemistry*; D013196:Dihydrotestosterone / Q000032:analysis; D006801:Humans; D008297:Male; D012661:Semen / Q000737:chemistry*; D013076:Sperm Count; D013094:Spermatozoa / Q000166:cytology*; D013739:Testosterone / Q000032:analysis
D000728:Androgens; D013196:Dihydrotestosterone; D013739:Testosterone; D000735:Androstenedione