Parasite immunology: pathways for expelling intestinal helminths.
Helminth parasites induce strong immune responses that are initiated by cytokines, in the first instance interleukin-4 and interleukin-13. Recent studies of knockout mice deficient in these mediators or their shared receptor have revealed discrete pathways required for expulsion of different gut parasites.
Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh, EH10 5PB, Scotland, UK. r.maizels@ed.ac.uk
R M
RM
Maizels
M J
MJ
Holland
D000818:Animals; D016207:Cytokines / Q000276:immunology*; D004804:Eosinophils / Q000276:immunology; D007411:Intestinal Diseases, Parasitic / Q000276:immunology*; D008407:Mast Cells / Q000276:immunology; D051379:Mice; D009348:Nematoda / Q000276:immunology*; D009349:Nematode Infections / Q000276:immunology*
D016207:Cytokines