Depot sulfonamid associated linear IgA bullous dermatosis with erythema multiforme-like clinical features.
A case of erythema multiforme-like reaction, following therapy with sulfadimethoxynum is reported in a 19-year-old male patient. Histological examination demonstrated a subepidermal bulla and direct immunofluorescence revealed linear deposition of IgA at the dermoepidermal junction. These observations illustrate that linear IgA bullous dermatosis can mimic the clinical features of erythema multiforme and suggest the possibility of drug-induced pathogenesis.
Department of Dermatology, Military Medical Academy, Sofia, Bulgaria.
S
S
Tonev
S
S
Vasileva
M
M
Kadurina
D000328:Adult; D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D004892:Erythema Multiforme / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D008297:Male; D012867:Skin / Q000187:drug effects / Q000473:pathology; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D013449:Sulfonamides / Q000009:adverse effects* / Q000627:therapeutic use
D000890:Anti-Infective Agents; D007070:Immunoglobulin A; D013449:Sulfonamides