The role of N-methyl-D-aspartate receptor in the guinea pig inner ear after unilateral labyrinthectomy.
To investigate the role of the N-methyl-D-aspartate (NMDA) receptor in the vestibular periphery, vestibular compensation in the guinea pig was studied following chemical unilateral labyrinthectomy by osmotic pump administration of streptomycin sulfate (SM) with or without D-2-amino-5-phosphonovalerate (D-APV), one of the NMDA receptor antagonists. All animals administrated SM (SM group) or SM and D-APV (SM + D-APV group) showed spontaneous nystagmus and head tilt. The maximum degree of yaw head tilt in the SM + D-APV group was statistically smaller than that in the SM group. Moreover the time constant for head tilt in the SM + D-APV group was statistically shorter than that in the SM group. These results indicate that the NMDA receptor in the vestibular periphery influences vestibular compensation after unilateral labyrinthectomy.
Department of Otolaryngology, Yamaguchi University School of Medicine, Ube-City, Japan. shimo-h@po.cc.yamaguchi-u.ac.jp
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H
Shimogori
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H
Yamashita
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M
Takahashi
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents; D007758:Ear, Inner / Q000737:chemistry* / Q000187:drug effects / Q000601:surgery*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D006168:Guinea Pigs; D008297:Male; D009759:Nystagmus, Pathologic / Q000503:physiopathology; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000502:physiology*; D013307:Streptomycin; D014725:Vestibular Nerve / Q000502:physiology; D014882:Water-Electrolyte Balance / Q000502:physiology
D000900:Anti-Bacterial Agents; D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D015763:2-Amino-5-phosphonovalerate; D013307:Streptomycin