Accelerated cyclization of lambda DNA.
In the presence of spermidine, the DNA molecule of the bacteriophage lambda undergoes a coil-globule transition. We report here that the cyclization of this molecule in its globular state is greatly accelerated (by more than 10(4)-fold) in comparison with the cyclization reaction taking place in the coil conformation.
Laboratoire Léon-Brillouin, CEA-CNRS, CEA/Saclay, Gif-sur-Yvette, France.
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D010582:Bacteriophage lambda / Q000235:genetics*; D004279:DNA, Viral / Q000187:drug effects* / Q000235:genetics; D009690:Nucleic Acid Conformation; D013095:Spermidine / Q000494:pharmacology*; D013997:Time Factors
D004279:DNA, Viral; D013095:Spermidine