Retroviral transfer of antisense sequences results in reduction of C-Abl and induction of apoptosis in hemopoietic cells.
Fels Institute for Cancer Research and Molecular Biology, Departments of Pathology and Laboratory Medicine, Biochemistry, Microbiology and Immunology, Temple University School of Medicine, Philadelphia, Pa., USA.
R
R
Daniel
S
S
Chung
H
H
Chen
P M
PM
Wong
D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D002455:Cell Division; D002460:Cell Line; D016373:DNA, Antisense; D018014:Gene Transfer Techniques; D016313:Genes, abl / Q000502:physiology*; D005822:Genetic Vectors; D006133:Growth Substances / Q000494:pharmacology; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D008214:Lymphocytes / Q000166:cytology*; D051379:Mice; D016315:Proto-Oncogene Proteins c-abl / Q000032:analysis; D016372:RNA, Antisense / Q000032:analysis; D012333:RNA, Messenger / Q000032:analysis; D016185:Receptors, Interleukin-3 / Q000235:genetics; D012190:Retroviridae / Q000235:genetics; D015854:Up-Regulation
D016373:DNA, Antisense; D006133:Growth Substances; D016372:RNA, Antisense; D012333:RNA, Messenger; D016185:Receptors, Interleukin-3; D016315:Proto-Oncogene Proteins c-abl