Biotransformation of resveratrol to piceid by Bacillus cereus.
Microbial transformation of resveratrol (1), trans-3,4', 5-trihydroxystilbene, was studied. Preparative scale biotransformation of 1 with whole-cell suspensions of Bacillus cereus UI 1477 resulted in the production of metabolite 2 which was identical in all respects to an authentic sample of piceid, resveratrol 3-O-beta-D-glucoside.
Division of Basic Pharmaceutical Sciences, School of Pharmacy, Northeast Louisiana University, Monroe, Louisiana 71209, USA.
R H
RH
Cichewicz
S A
SA
Kouzi
D000972:Antineoplastic Agents, Phytogenic / Q000378:metabolism; D000975:Antioxidants / Q000378:metabolism; D001409:Bacillus cereus / Q000378:metabolism*; D001711:Biotransformation; D004791:Enzyme Inhibitors / Q000378:metabolism; D005960:Glucosides / Q000737:chemistry / Q000378:metabolism*; D008954:Models, Biological; D015394:Molecular Structure; D010975:Platelet Aggregation Inhibitors / Q000378:metabolism; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry / Q000378:metabolism*
D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D004791:Enzyme Inhibitors; D005960:Glucosides; D010975:Platelet Aggregation Inhibitors; D013267:Stilbenes; D000077185:Resveratrol; C058229:polydatin