Chronic staphylococcal scalded skin syndrome.
Staphylococcal scalded skin syndrome (SSSS), not previously recorded as a chronic disease, persisted for 2 years in a 50-year-old woman with epilepsy and cerebellar ataxia. Lesions initially suggestive of erythema multiforme and toxic epidermal necrolysis evolved over 2 years into those typical for SSSS, with extensive erosions and subcorneal blisters, showing an epidermal split at the granular cell layer. Exfoliatin A-producing phage I-III Staphylococcus aureus, previously linked only to acute mild adult cases of SSSS, was cultured from purulent discharge in the patient's eyes, ears and open skin lesions. The roles of epilepsy and antiepileptic medications are discussed as possible predisposing factors.
Shelley
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Division of Dermatology, Department of Medicine, Medical College of Ohio, PO Box 10008, Toledo, OH 43699-0008, USA.
Shelley
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WB
Talanin
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NY
D000927:Anticonvulsants / Q000009:adverse effects; D002908:Chronic Disease; D004828:Epilepsies, Partial / Q000150:complications; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D008875:Middle Aged; D013206:Staphylococcal Scalded Skin Syndrome / Q000150:complications / Q000276:immunology / Q000473:pathology*
D000927:Anticonvulsants