[Interaction between paroxetine and clomipramine as a possible reason for admission to a department of internal medicine].
A 79-year-old woman was admitted due to increasing dizziness during the past six days. She had been treated with clomipramine 75 mg daily for years, and in addition had received paroxetine 20 mg daily for the last eight days. Both drugs were terminated and the symptoms disappeared. Thirty-six hours after taking the last drugs, the S-clomipramine plus S-desmethylclomipramine were 790 mmol/l. The symptoms were probably related to this high serum level caused by interaction with paroxetine.
Odense Universitet, afdeling for klinisk farmakologi.
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D000368:Aged; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D002997:Clomipramine / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics; D065690:Cytochrome P-450 CYP2D6 Inhibitors; D004244:Dizziness / Q000139:chemically induced*; D004347:Drug Interactions; D005260:Female; D005838:Genotype; D006760:Hospitalization; D006801:Humans; D017374:Paroxetine / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics
D000929:Antidepressive Agents, Tricyclic; D002997:Clomipramine; D019389:Cytochrome P-450 CYP2D6; D065690:Cytochrome P-450 CYP2D6 Inhibitors; D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors
Interaktion imellem paroxetin og clomipramin som mulig årsag til indlaeggelse på medicinsk afdeling.