Taurine entry into perilymph of the guinea pig.
Taurine is a beta-aminosulfonic acid and is a ubiquitous amino acid whose role in the cochlea is not well established. In this study, its entry from blood into perilymph was investigated in the guinea pig as animal model. The penetration rate of [3H]taurine (molecular weight 125) into the perilymph of the scala vestibuli was measured 1 and 2 h after the intravenous infusion of [3H]taurine in nephrectomized animals. Results showed a rate of penetration in perilymph related to plasma at 36 +/- 4.7% (n = 5) after 1 h and 43 +/- 5.6% (n = 5) after 2 h. Compared to the penetration rate of urea (molecular weight 60) and mannitol (molecular weight 186) reported previously in rats, a passive entry of taurine into perilymph through the blood-perilymph barrier is suggested.
Laboratoire d'Audiologie Expérimentale et Clinique, CJF INSERM 97-04, Université Bordeaux II, France.
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Angelini
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Teixeira
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JM
Aran
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Ferrary
D000818:Animals; D001646:Bile / Q000737:chemistry; D001798:Blood Proteins / Q000032:analysis; D002712:Chlorides / Q000032:analysis / Q000097:blood; D004195:Disease Models, Animal; D004234:Diuretics, Osmotic / Q000493:pharmacokinetics; D005500:Follow-Up Studies; D006168:Guinea Pigs; D007262:Infusions, Intravenous; D008353:Mannitol / Q000493:pharmacokinetics; D009392:Nephrectomy; D009994:Osmolar Concentration; D010498:Perilymph / Q000737:chemistry / Q000378:metabolism*; D011188:Potassium / Q000032:analysis / Q000097:blood; D011506:Proteins / Q000032:analysis; D019275:Radiopharmaceuticals; D051381:Rats; D012533:Scala Tympani / Q000378:metabolism; D012964:Sodium / Q000032:analysis / Q000097:blood; D013654:Taurine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D014316:Tritium; D014508:Urea / Q000493:pharmacokinetics
D001798:Blood Proteins; D002712:Chlorides; D004234:Diuretics, Osmotic; D011506:Proteins; D019275:Radiopharmaceuticals; D014316:Tritium; D013654:Taurine; D008353:Mannitol; D014508:Urea; D012964:Sodium; D011188:Potassium