From slowly progressive amnesic syndrome to rapidly progressive Alzheimer disease.
A 57-year-old woman had a neuropsychologically documented 5-year history of a slowly progressive amnesic syndrome followed by a 1-year history of rapidly progressive dementia. There was no family history of dementia. Magnetic resonance imaging failed to show a structural basis, electroencephalography failed to show changes of Creutzfeldt-Jakob disease, and cerebrospinal fluid examination was normal. A diagnosis of Alzheimer disease was confirmed by brain biopsy. The abrupt change in disease course was unique but suggested probable overlap between posited subtypes of Alzheimer disease.
Department of Neurology, Mayo Clinic, Scottsdale, Arizona 85259, USA.
R J
RJ
Caselli
M E
ME
Couce
D
D
Osborne
H G
HG
Deen
J P
JP
Parisi
D000544:Alzheimer Disease / Q000175:diagnosis* / Q000523:psychology; D000647:Amnesia / Q000175:diagnosis* / Q000523:psychology; D001921:Brain / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009483:Neuropsychological Tests; D013577:Syndrome