[4-Nitroquinoline-1-oxide induced adaptive and cross resistance to ultraviolet rays and nalidixic acid in Enterococcus faecalis].
The resistance of Enterococcus faecalis to exposure to 4-nitroquinoline-1-oxide (4-NQO) as well as to UV irradiation and nalidixic acid was shown to increase as a result of reinoculations in medium containing 4-NQO. Irradiation of cells with UV254 (20, 60, or 100 J/m2) did not increase their resistance to 4-NQO. The desmutagenic activity of 4-NQO-adapted cells in the case of mutagenesis induced by 4-NQO was higher than in control cells. The mechanism of induced resistance is discussed.
Moscow State University, Russia.
L I
LI
Vorob'eva
T A
TA
Cherdyntseva
D015112:4-Nitroquinoline-1-oxide / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D013293:Enterococcus faecalis / Q000187:drug effects* / Q000235:genetics / Q000528:radiation effects; D016296:Mutagenesis; D009153:Mutagens / Q000494:pharmacology*; D009268:Nalidixic Acid / Q000494:pharmacology*; D014466:Ultraviolet Rays
D009153:Mutagens; D009268:Nalidixic Acid; D015112:4-Nitroquinoline-1-oxide
Indutsirovannaia pod deĭstviem 4-nitrokhinolin-1-oksida adaptivnaia i perekrestnaia ustoĭchivost' k ul'trafioletovomu izlucheniiu i nalidiksovoĭ kislote u Enterococcus faecalis.