Comparison of the effectiveness of 2,3-dimercaptopropanol (BAL) and meso-2,3-dimercaptosuccinic acid (DMSA) as protective agents against mercuric chloride-induced nephrotoxicity in rats.
The effectiveness of 2,3-dimercaptopropanol (BAL) and meso-2,3-dimercaptosuccinic acid (DMSA) on HgCl2-induced nephrotoxicity was studied in the rat. Seven groups of adult male rats were given a single sc toxic dose of HgCl2 (0.68 mg/kg) followed by 0.9% saline (positive control group), BAL (15, 30, and 60 mg/kg) or DMSA (50, 100, and 200 mg/kg) administered ip at 0, 24, 48, and 72 h thereafter. Although the renal function of HgCl2-exposed rats was slightly improved after BAL administration, Hg concentrations in the kidney were only reduced at 60 mg/kg. In addition, the protective effect of BAL was not dose-related. In contrast to BAL, DMSA was effective in increasing the urinary excretion of Hg and in reducing the renal Hg content. These results show that DMSA would be more effective than BAL in preventing or in protecting against inorganic Hg-induced nephrotoxicity.
Laboratory of Toxicology and Environmental Health, School of Medicine, Rovira i Virgili University, Reus, Spain.
A
A
de la Torre
M
M
Bellés
J M
JM
Llobet
E
E
Mayayo
J L
JL
Domingo
D000818:Animals; D000931:Antidotes / Q000494:pharmacology; D002614:Chelating Agents / Q000494:pharmacology*; D003404:Creatinine / Q000097:blood / Q000652:urine; D004112:Dimercaprol / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008627:Mercuric Chloride / Q000633:toxicity*; D008628:Mercury / Q000032:analysis / Q000652:urine; D011507:Proteinuria / Q000139:chemically induced / Q000188:drug therapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D004113:Succimer / Q000494:pharmacology*; D014508:Urea / Q000097:blood / Q000652:urine
D000931:Antidotes; D002614:Chelating Agents; D004112:Dimercaprol; D008627:Mercuric Chloride; D014508:Urea; D003404:Creatinine; D004113:Succimer; D008628:Mercury