HLA-DP-associated susceptibility to the optico-spinal form of multiple sclerosis in the Japanese.
We studied polymorphism of the HLA-DP gene in 46 patients with optico-spinal form (Asian type) multiple sclerosis (MS) showing recurrent opticomyelitis and 46 patients with Western type MS with disseminated central nervous system involvement. We previously reported a significant association between an HLA-DRB1 *1501-DRB5*0101 haplotype and susceptibility to Western type but not Asian type MS. In the present study, we found that the frequencies of DPA1 *0202 and DPB1 *0501 alleles were significantly increased in patients with Asian type MS, as compared with findings in 92 healthy control subjects (91.3% vs 65.2%, P(corr)<0.05 and 89.1% vs 63.0%, P(corr)<0.05 respectively), but not in Western type MS. Our data provide further evidence that Asian and Western type MS are distinct regarding the immunogenetic background.
Ito
H
H
Department of Neuroscience and Immunology, Kumamoto University Graduate School of Medical Sciences, Honjo, Japan.
Yamasaki
K
K
Kawano
Y
Y
Horiuchi
I
I
Yun
C
C
Nishimura
Y
Y
Kira
J
J
D000483:Alleles; D004198:Disease Susceptibility; D005787:Gene Frequency; D006682:HLA-DP Antigens / Q000032:analysis* / Q000235:genetics*; D006801:Humans; D007564:Japan; D009103:Multiple Sclerosis / Q000145:classification / Q000235:genetics* / Q000276:immunology*; D011110:Polymorphism, Genetic
D006682:HLA-DP Antigens