[Fluorescent spectral study of synthetic activity of animal blood lymphocytes under continuous gamma-irradiation].
The effect of continuous gamma-irradiation with dose rate 14.4 cGy/day on the synthetic activity of rat and rabbit blood lymphocytes stained with acridine orange was studied by fluorescent microspectrometry. The changes of the synthetic activity of blood lymphocytes, described by the parameter alpha, occurred in four main stages. The essential differences in changes of synthetic activity between rat and rabbit were observed at the first stage. In the rats, parameter alpha sharply increased, as a result of the stimulatory effect of low dose irradiation. In the rabbits, being more radiosensitive, at the first stage, parameter alpha was about control values, as a result of two opposite directed processes, stimulatory and damaging. At the fourth stage, decrease of the synthetic activity was both in the rats and in the rabbits owing to damaging effect of continuous gamma-irradiation during long time.
Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino.
N A
NA
Karnaukhova
A L
AL
Sergievich
G E
GE
Aksenova
V N
VN
Karnaukhov
D000818:Animals; D005720:Gamma Rays; D008213:Lymphocyte Activation / Q000528:radiation effects*; D008214:Lymphocytes / Q000276:immunology* / Q000528:radiation effects*; D008297:Male; D012313:RNA / Q000032:analysis*; D011817:Rabbits; D011833:Radiation Injuries, Experimental / Q000097:blood*; D051381:Rats; D017208:Rats, Wistar; D013050:Spectrometry, Fluorescence; D014916:Whole-Body Irradiation
D012313:RNA
Fluorestsentnye spektral'nye issledovaniia sinteticheskoĭ aktivnosti llimfotsitov krovi zhivotnykh pri khronicheskom gamma-obluchenii.