Bilateral temporal lobe necrosis after radiotherapy: confounding SPECT results.
A patient with seizures and a contrast-enhancing temporal lesion after radiation therapy for a chondrosarcoma of the nasal septum is described. To differentiate between radiation necrosis and recurrent tumor, thallium-201 (201Tl) SPECT was used. 201Tl SPECT revealed high local accumulation suggesting tumor growth; however, pathologic examination demonstrated focal necrosis with reactive changes but without tumor. The 201Tl SPECT findings in this patient demonstrate a possible diagnostic pitfall in differentiating recurrent tumor from radiation necrosis.
de Vries
B
B
Department of Neurology, University Hospital Utrecht, The Netherlands.
Taphoorn
M J
MJ
van Isselt
J W
JW
Terhaard
C H
CH
Jansen
G H
GH
Elsenburg
P H
PH
D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000532:radiotherapy*; D002813:Chondrosarcoma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009300:Nasal Septum / Q000473:pathology; D009336:Necrosis; D011878:Radiotherapy / Q000009:adverse effects; D012008:Recurrence; D013702:Temporal Lobe / Q000473:pathology*; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon
D013794:Thallium Radioisotopes