Administration of a crystalloid fluid preload does not prevent the decrease in arterial blood pressure after induction of anaesthesia with propofol and fentanyl.
Anaesthesia was induced in 58 women (ASA I or II) undergoing elective gynaecological procedures, using propofol 2.5 mg kg-1 and fentanyl 1.5 micrograms kg-1. Patients were allocated to receive 20 ml kg-1 of crystalloid fluid preload over 20 min or to receive no fluids before induction of anaesthesia. A significant decrease in systolic arterial pressure (< 75% of baseline value) occurred in both the fluid-loaded and the control groups, and was similar in both groups. Administration of a fluid preload did not attenuate the decrease in systolic arterial pressure after induction of anaesthesia with propofol and fentanyl.
Turner
R J
RJ
Prince of Wales Hospital, Randwick, NSW, Australia.
Gatt
S P
SP
Kam
P C
PC
Ramzan
I
I
Daley
M
M
D000328:Adult; D018686:Anesthetics, Intravenous / Q000009:adverse effects*; D000077324:Crystalloid Solutions; D005260:Female; D005283:Fentanyl / Q000009:adverse effects; D005440:Fluid Therapy; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007022:Hypotension / Q000139:chemically induced / Q000517:prevention & control*; D007552:Isotonic Solutions; D010952:Plasma Substitutes / Q000627:therapeutic use*; D011300:Preoperative Care; D015742:Propofol / Q000009:adverse effects*; D015532:Rehydration Solutions / Q000627:therapeutic use*; D016037:Single-Blind Method
D018686:Anesthetics, Intravenous; D000077324:Crystalloid Solutions; D007552:Isotonic Solutions; D010952:Plasma Substitutes; D015532:Rehydration Solutions; D005283:Fentanyl; D015742:Propofol