[Effect of halogenated quaternary ammonium on cultured tumor cells].
This work reports the action of one halogenic quaternary ammonium compound on the in-vitro proliferation of different lines of human cancer cells. IC 50 inhibition growth was observed at a concentration of 2.10(-6) mol and T1 growth at 3.10(-6)-5.10(-5) mol. These results seem to indicate that halogenic quaternary ammoniums present a potent growth inhibitory activity on different cancer cells lines. The presence of a quaternary ammonium group, responsible for some alkylating effect, could explain such a result.
Gastaud
J M
JM
Centre régional de lutte contre le cancer, Montpellier, France.
Senelar
R
R
Pujol
H
H
D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003124:Colorimetry; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D016015:Logistic Models; D009316:National Institutes of Health (U.S.); D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D013778:Tetrazolium Salts; D014407:Tumor Cells, Cultured; D014481:United States
C115039:GMS-041 F; D000644:Quaternary Ammonium Compounds; D013778:Tetrazolium Salts
Effet d'ammonium quaternaire halogéné sur des cultures de cellules tumorales.