[Determination of fetal umbilical artery flow velocity during induction of term labor by mifepristone].
OBJECTIVE
To evaluate the effects of mifepristone for induction of term labor on blood supply of placenta.


METHODS
97 pregnant women (38-42 gestational weeks) were recruited, and randomly allocated into 2 groups, group 1 (n = 49) mifepristone was given orally 50 mg q12h for 2 days followed by misoprostol intravaginally (25 micrograms q12h); group 2 (n = 48), Sodium prasterone sulfate intravenous injection of 200 mg qd for 3 days followed by oxytocin intravenous infusion. Fetal umbilical artery flow velocity was determined before and 36-48 hours after treatment to observe the variation of S/D value in both groups.


RESULTS
There were no significant variations of S/D value in both groups (P > 0.05).


CONCLUSIONS
Mifipristone for induction of term labor (50 mg q12h for 2 days) is effective, and has no significant influence on the blood supply of placenta.
Hospital of Obstetrics and Gynecology, Shanghai Medical University.
X
X
Jiang
H
H
Wang
Z
Z
Zhang
D000021:Abortifacient Agents, Steroidal / Q000009:adverse effects*; D000328:Adult; D001783:Blood Flow Velocity; D005260:Female; D006801:Humans; D007751:Labor, Induced / Q000379:methods; D015735:Mifepristone / Q000009:adverse effects*; D010920:Placenta / Q000098:blood supply*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011897:Random Allocation; D014469:Umbilical Arteries / Q000502:physiology*
D000021:Abortifacient Agents, Steroidal; D015735:Mifepristone