The mouse Fkh1/Mf1 gene: cDNA sequence, chromosomal localization and expression in adult tissues.
The 'winged helix' or 'forkhead' transcription factor gene family is defined by a common 100-amino-acid DNA-binding motif. Here, we describe the chromosomal position, start site of transcription, sequence and adult expression pattern of the mouse Fkh1/Mf1 (Forkhead homologue 1/mesoderm/mesenchyme forkhead 1) gene. This gene contains one exon and encodes a protein of 553 amino acids that is highly related to the mouse MFH1 protein. The Fkh1/Mf1 mRNA is expressed widely in adult tissues. Linkage analysis showed that the Fkh1/Mf1 gene is localized to chromosome 13 at 17.02cM from the centromer, in close proximity to Bmp6 and Hfh1, another distinct member of the winged helix gene family.
Division Molecular Biology of the Cell I, German Cancer Research Center, Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany.
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D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D002874:Chromosome Mapping; D018076:DNA, Complementary / Q000302:isolation & purification*; D004622:Embryo, Mammalian / Q000737:chemistry; D051858:Forkhead Transcription Factors; D015870:Gene Expression / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D012313:RNA / Q000032:analysis; D017422:Sequence Analysis, DNA; D014157:Transcription Factors / Q000096:biosynthesis / Q000235:genetics* / Q000302:isolation & purification
D018076:DNA, Complementary; D051858:Forkhead Transcription Factors; C112890:Foxc1 protein, mouse; D014157:Transcription Factors; D012313:RNA