Design and synthesis of conformationally constrained inhibitors of high-affinity, sodium-dependent glutamate transporters.
Chamberlin
A R
AR
Department of Chemistry, University of California, Irvine 92717, USA.
Koch
H P
HP
Bridges
R J
RJ
D027322:Amino Acid Transport System X-AG; D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism; D002352:Carrier Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D002458:Cell Fractionation / Q000379:methods; D002499:Centrifugation, Density Gradient / Q000379:methods; D002531:Cerebellum / Q000378:metabolism*; D003198:Computer Simulation; D015195:Drug Design; D050491:Glutamate Plasma Membrane Transport Proteins; D018698:Glutamic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D008297:Male; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D011869:Radioligand Assay; D051381:Rats; D017207:Rats, Sprague-Dawley; D012964:Sodium / Q000378:metabolism*; D013379:Substrate Specificity; D027981:Symporters; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D014316:Tritium
D027322:Amino Acid Transport System X-AG; D002352:Carrier Proteins; D050491:Glutamate Plasma Membrane Transport Proteins; D027981:Symporters; D014316:Tritium; D001224:Aspartic Acid; D018698:Glutamic Acid; D012964:Sodium