Serum concentrations of sICAM-1, sE-, sP- and sL-selectins in patients with Schistosoma mansoni infection and association with disease severity.
Increased serum concentrations of soluble intercellular adhesion molecule-1 (sICAM-1, CD54) and of soluble E- (CD62E), but not soluble P- (CD62P) and L- (CD62 L) selectins, were detected in Malagasy patients living in an hyperendemic focus of Schistosoma mansoni. Levels of sICAM-1 remained elevated for several months after treatment with praziquantel. Serum levels of ICAM-1, but not of other markers, were significantly correlated with the disease severity, as indicated by ultrasonographical data, and with some circulating fibrosis markers (at least hyaluronic acid). sICAM-1 level may reflect endothelial inflammatory reactions, probably harmful, in the liver and may be useful for monitoring morbidity evolution in schistosomiasis mansoni.
ImmunoParasitology & Epidemiology Units, Institut Pasteur de Madagascar, BP 1274, Antananarivo 101, Madagascar.
P
P
Esterre
A
A
Raobelison
C E
CE
Ramarokoto
V E
VE
Ravaoalimalala
P
P
Boisier
J
J
Roux
D000293:Adolescent; D000328:Adult; D000818:Animals; D015415:Biomarkers / Q000097:blood; D002648:Child; D005243:Feces / Q000469:parasitology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010270:Parasite Egg Count; D012550:Schistosoma mansoni; D012555:Schistosomiasis mansoni / Q000097:blood* / Q000000981:diagnostic imaging; D019087:Selectins / Q000097:blood*; D012720:Severity of Illness Index; D014463:Ultrasonography
D015415:Biomarkers; D019087:Selectins; D018799:Intercellular Adhesion Molecule-1; D006820:Hyaluronic Acid