[A study of correlation between essential hypertension and HLA-DQA1 alleles].
OBJECTIVE
To analyse the hereditary susceptibility by genotyping of HLA-DQA1 alleles in essential hypertensives.


METHODS
The allelic types of HLA-DQA1 were detected by PCR-SSP technic in 52 cases of essential hypertensives and 86 normal individuals as the control.


RESULTS
The frequency of HLA-DQA1*0302 allele in hypertensive group was markedly higher than that in normal control group (17.9572 vs 3.5531), but the frequency of HLA-DQA1*0103 allele in normal group was higher than that in hypertensive group.


CONCLUSIONS
HLA-DQA1*0302 may be a correlative gene of essential hypertension, whereas HLA-DQA1*0103 may be a defence gene of hypertension.
Cardiovascular Division, People's Hospital, Beijing Medical University, Beijing, 100044 P. R. China.
N
N
Sun
W
W
Yan
Z
Z
Yan
S
S
Wang
G
G
Li
J
J
Wang
D000328:Adult; D000368:Aged; D000483:Alleles; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged
D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; C069050:HLA-DQA1 antigen