Use of coreceptors other than CCR5 by non-syncytium-inducing adult and pediatric isolates of human immunodeficiency virus type 1 is rare in vitro.
We have tested a panel of pediatric and adult human immunodeficiency virus type 1 (HIV-1) primary isolates for the ability to employ the following proteins as coreceptors during viral entry: CCR1, CCR2b, CCR3, CCR4, CCR5, CCR8, CXCR4, Bonzo, BOB, GPR1, V28, US28, and APJ. Most non-syncytium-inducing isolates could utilize only CCR5. All syncytium-inducing viruses used CXCR4, some also employed V28, and one (DH123) used CCR8 and APJ as well. A longitudinal series of HIV-1 subtype B isolates from an infected infant and its mother utilized Bonzo efficiently, as well as CCR5. The maternal isolates, which were syncytium inducing, also used CXCR4, CCR8, V28, and APJ.
Zhang
Y J
YJ
Aaron Diamond AIDS Research Center, The Rockefeller University, New York University School of Medicine, New York, New York 10016, USA.
Dragic
T
T
Cao
Y
Y
Kostrikis
L
L
Kwon
D S
DS
Littman
D R
DR
KewalRamani
V N
VN
Moore
J P
JP
D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000821:virology; D002460:Cell Line; D005260:Female; D015752:Genes, env; D005816:Genetic Complementation Test; D015658:HIV Infections / Q000635:transmission / Q000821:virology*; D015497:HIV-1 / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology*; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D011247:Pregnancy; D019713:Receptors, CCR5 / Q000235:genetics / Q000502:physiology*; D019718:Receptors, CXCR4 / Q000235:genetics / Q000502:physiology; D015728:Receptors, HIV / Q000235:genetics / Q000502:physiology*; D014162:Transfection; D014779:Virus Replication
D019713:Receptors, CCR5; D019718:Receptors, CXCR4; D015728:Receptors, HIV