Effect of dietary curcumin and dibenzoylmethane on formation of 7,12-dimethylbenz[a]anthracene-induced mammary tumors and lymphomas/leukemias in Sencar mice.
Female Sencar mice (6 weeks old) were administered 1 mg of 7,12-dimethylbenz[a]anthracene (DMBA) by oral gavage once a week for 5 weeks. At 20 weeks after the first dose of DMBA, 68% of mice developed mammary tumors (the average 1.08 tumors per mouse) and 45% had lymphomas/leukemias. Feeding 1% dibenzoylmethane (DBM) in AIN 76A diet, starting at 2 weeks before the first dose of DMBA and continuing until the end of the experiment, inhibited both the multiplicity and incidence of DMBA-induced mammary tumor by 97%. The incidence of lymphomas/leukemias was completely inhibited by 1% DBM diet. In contrast, feeding 2% curcumin diet had little or no effect on the incidence of mammary tumors, and the incidence of lymphomas/leukemias was reduced by 53%.
Laboratory for Cancer Research, College of Pharmacy, Rutgers, The State University of New Jersey, Piscataway 08854-8020, USA.
M T
MT
Huang
Y R
YR
Lou
J G
JG
Xie
W
W
Ma
Y P
YP
Lu
P
P
Yen
B T
BT
Zhu
H
H
Newmark
C T
CT
Ho
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D001565:Benzoates / Q000494:pharmacology*; D047188:Chalcones; D003474:Curcumin / Q000494:pharmacology*; D005260:Female; D007942:Leukemia, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D008223:Lymphoma / Q000139:chemically induced / Q000517:prevention & control*; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D051379:Mice
D016588:Anticarcinogenic Agents; D001565:Benzoates; D047188:Chalcones; D015127:9,10-Dimethyl-1,2-benzanthracene; C061481:dibenzoylmethane; D003474:Curcumin