Distribution and excretion of radiolabelled tert-butylhydroquinone in Fischer 344 rats.
Uniformly 14C-ring-labelled tert-butylhydroquinone (TBHQ) was diluted with non-radioactive TBHQ and administered orally (for excretion studies) to Fischer 344 rats. An average of 72.9% and 10.6% of the administered radioactivity was recovered in the urine and faeces, respectively, of male rats, and 77.3% and 8.2% in the urine and faeces, respectively, of female rats in 4 days. No significant sex-related differences were found in either excretion, tissue distribution or urinary metabolites of TBHQ-derived radiolabel. For distribution studies, intraperitoneal doses were administered to female rats, and tissue levels of radiolabel were determined at various times after dosing. The parent compound quickly disappeared from tissue in vivo. The highest concentrations of radiolabel were found in the liver and kidneys. The urinary metabolites consisted of conjugated TBHQ and unidentified polar substance(s).
Division of Toxicology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, MD 20708, USA.
G J
GJ
Ikeda
P P
PP
Sapienza
I A
IA
Ross
D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics*; D002250:Carbon Radioisotopes; D002855:Chromatography, Thin Layer; D005260:Female; D006873:Hydroquinones / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D012737:Sex Factors
D000975:Antioxidants; D002250:Carbon Radioisotopes; D006873:Hydroquinones; C018855:2-tert-butylhydroquinone