Epstein-Barr virus in the pathogenesis of Hodgkin's disease.
Epidemiologic and clinico-pathologic features of Hodgkin's disease suggest that an infectious agent may be involved in the pathogenesis of this puzzling disorder. Recently accumulated data provide direct evidence supporting a causal role of Epstein-Barr virus in a significant proportion of cases. In addition to allowing a better understanding of the complex pathogenesis of Hodgkin's disease, these virological advances, briefly reviewed herein, also constitute an important basis for the development of new therapeutic strategies.
Dolcetti
R
R
Division of Experimental Oncology 1, Centro di Riferimento Oncologico, Aviano, Italy.
Boiocchi
M
M
D000818:Animals; D019309:Epstein-Barr Virus Nuclear Antigens / Q000032:analysis; D004854:Herpesvirus 4, Human / Q000302:isolation & purification / Q000472:pathogenicity*; D006689:Hodgkin Disease / Q000453:epidemiology / Q000821:virology*; D006801:Humans; D014412:Tumor Virus Infections / Q000821:virology; D014763:Viral Matrix Proteins / Q000032:analysis
C037662:EBV-associated membrane antigen, Epstein-Barr virus; D019309:Epstein-Barr Virus Nuclear Antigens; D014763:Viral Matrix Proteins