Hibernating myocardium: its pathophysiology and clinical role.
Myocardial hibernation, as first defined by Rahimtoola, is a state of chronic contractile dysfunction in patients with coronary artery disease which is fully reversible upon reperfusion. Clinical conditions consistent with the existence of myocardial hibernation include unstable and stable angina, myocardial infarction heart failure, and anomalous origin of coronary arteries. The mechanisms of hibernation are not known. Morphological alterations have been described in the hibernating area of patients, but these information are strongly affected by the diagnostic criteria utilized to screen patients. It has been postulated that hibernation is an adaptive phenomenon occurring during ischemia. In this context, downregulation of contraction is not regarded as a consequence of energetic deficit, but as a regulatory event aimed at reducing energy expenditure, thereby maintaining integrity and viability. Thus, hibernation might bear a relationship to the phenomenon of low-flow perfusion-contraction matching, or repetitive stunning or preconditioning. Clear-cut evidence for the mechanism of hibernation in the clinical setting seems likely to remain elusive, because of the nature of the studies needed to document it. Current experimental evidence supports the view that hibernation, stunning, preconditioning, or their coexistence can be responsible for regional myocardial contractile dysfunction which is reversible upon reperfusion. These are all adaptive and protective phenomena independent of their terminology and strict definitions and do not always apply to the extremely complex situation of myocardial ischemia in man.
Ferrari
R
R
Cattedra di Cardiologia, Universita' degli Studi di Brescia, Italy.
Ferrari
F
F
Benigno
M
M
Pepi
P
P
Visioli
O
O
D000222:Adaptation, Physiological; D006321:Heart / Q000503:physiopathology; D016027:Heart Transplantation; D006605:Hibernation; D006801:Humans; D009200:Myocardial Contraction; D017202:Myocardial Ischemia / Q000209:etiology / Q000503:physiopathology* / Q000601:surgery; D015425:Myocardial Reperfusion