[The effect of pyrimidine derivatives on experimental stomach ulcers in rats].
Experiments on albino rats showed that pyrimidine derivatives reduce hemorrhagic damage of the gastric mucosa caused by indomethacin, acetylsalicylic acid, and ortophen. The derivatives of pyrimidine prevent the decrease in total acid phosphatase activity, increase alkaline phosphatase, and reduce the activity of lactate dehydrogenase.
Institute of Organic Chemistry, Ufa Research Center, Russian Academy of Sciences, Russia.
A F
AF
Ismagilova
F S
FS
Zarudiĭ
D N
DN
Lazareva
Z F
ZF
Ismagilova
F P
FP
Savitskiĭ
Iu G
IuG
Tropynina
V A
VA
Davydova
V P
VP
Krivonogov
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D001241:Aspirin; D004008:Diclofenac; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D007213:Indomethacin; D010432:Pentoxyl / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011743:Pyrimidines / Q000627:therapeutic use*; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*; D014498:Uracil / Q000031:analogs & derivatives* / Q000627:therapeutic use
C113629:2-methyl-4-amino-6-oxypyrimidine; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D011743:Pyrimidines; D004008:Diclofenac; C008055:5-hydroxymethyluracil; D014498:Uracil; C008378:6-methyluracil; D010432:Pentoxyl; D001241:Aspirin; D007213:Indomethacin
Vliianie nekotorykh proizvodnykh pirimidina na éksperimental'nye iazvy zheludka u krys.