Gastric emptying in male neurologic trauma.
Prolonged gastric emptying half-time (GET1/2) has been observed in several neurological disorders. Most patients with moderate to severe neurologic trauma (NT) initially do not tolerate enteral or nasogastric feedings. However, previous findings of altered gastric emptying (GE) in patients with NT have been questionable. Quantitative measurements of GE, to determine a possible mechanism for intolerance to enteral feeding, are lacking. In this study, we measured GET1/2 sec of solid and liquid meals by radionuclide imaging in men who were neurologic trauma patients.


METHODS
A prospective study was conducted to assess GET1/2 in 30 men who were patients with spinal cord injuries (SCIs) and 20 men who were patients with head injuries (HIs) using radionuclide-labeled solid and liquid meals, respectively. Meanwhile, 18 and 14 male control subjects underwent the same imaging techniques for solid and liquid meals, respectively, to evaluate the normal ranges of solid and liquid GET1/2 sec (84.5 +/- 16.7 and 29.2 +/- 3.7 min).


RESULTS
In the 30 SCI patients, GET1/2 of solid meals was significantly prolonged (138.3 +/- 49.2 min, p < 0.05), and 53% (16/30) of patients had abnormal GET1/2. A more prolonged GET1/2 and a higher incidence of abnormal GET1/2 were observed in patients with high-level injury, when compared with patients with low-level injury (p < 0.05). In the 20 HI patients, GET1/2 of liquid meals was prolonged significantly (51.7 +/- 24.8 min, p < 0.05), and 65% (13/20) of patients had abnormal GET1/2. Coma, as indicated by the Glasgow Coma Scale score, was not a statistically significant factor influencing GET1/2 (p >0.05).


CONCLUSIONS
NT can cause significantly prolonged GE, especially in patients with high-level SCI.
Department of Nuclear Medicine, Taichung Veterans General Hospital, Taiwan, Republic of China.
C H
CH
Kao
S P
SP
ChangLai
P U
PU
Chieng
T C
TC
Yen
D000328:Adult; D016022:Case-Control Studies; D005746:Gastric Emptying; D016489:Head Injuries, Closed / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010833:Phytic Acid; D011446:Prospective Studies; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012016:Reference Values; D013119:Spinal Cord Injuries / Q000000981:diagnostic imaging / Q000503:physiopathology*; D013270:Stomach / Q000000981:diagnostic imaging
D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C026177:technetium phytate; D010833:Phytic Acid