Receptor tyrosine phosphatases: the worm clears the picture.
Recent work on the Caenorhabditis elegans clr-1 gene shows that the receptor tyrosine phosphatase that it encodes negatively regulates a receptor tyrosine kinase related to mammalian fibroblast growth factor receptors. This opens up a promising system for investigating receptor tyrosine phosphatase function.
Division of Biology, California Institute of Technology, Pasadena, California 91125, USA. zinnk@cco.caltech.edu
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D000818:Animals; D017173:Caenorhabditis elegans / Q000201:enzymology*; D029742:Caenorhabditis elegans Proteins; D015801:Helminth Proteins / Q000378:metabolism*; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism*; D054557:Receptor-Like Protein Tyrosine Phosphatases; D017468:Receptors, Fibroblast Growth Factor / Q000378:metabolism*
D029742:Caenorhabditis elegans Proteins; C112493:EGL-15 protein, C elegans; D015801:Helminth Proteins; D017468:Receptors, Fibroblast Growth Factor; C112492:CLR-1 protein, C elegans; D017027:Protein Tyrosine Phosphatases; D054557:Receptor-Like Protein Tyrosine Phosphatases