A genetic association study of the IGF-1 gene and radiological osteoarthritis in a population-based cohort study (the Rotterdam Study).
OBJECTIVE
A genetic association study was performed to investigate whether radiographical osteoarthritis (ROA) was associated with specific genotypes of the insulin-like growth factor I (IGF-1) gene.


METHODS
Subjects aged 55-65 years were selected from a population-based study of which ROA at the knee, hip, spine, and hand was assessed. Genotypes were determined of a polymorphism in the promoter region of the IGF-1 gene.


RESULTS
The IGF-1 locus was significantly associated with the presence of ROA (over-all adjusted OR for heterozygous subjects = 1.9, 95% CI 1.2, 3.1 and for homozygous subjects 3.6, 95% CI 0.8, 16.2).


CONCLUSIONS
These results suggest that variation at the IGF-1 locus is associated with ROA development and may play a part in ROA pathogenesis. To confirm these findings replication in another population-based sample is needed.
Meulenbelt
I
I
TNO Prevention and Health, Department of Vascular and Connective Tissue Research, Gaubius Laboratory, Leiden, The Netherlands.
Bijkerk
C
C
Miedema
H S
HS
Breedveld
F C
FC
Hofman
A
A
Valkenburg
H A
HA
Pols
H A
HA
Slagboom
P E
PE
van Duijn
C M
CM
D000368:Aged; D000483:Alleles; D015992:Body Mass Index; D015519:Bone Density; D005260:Female; D005838:Genotype; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000000981:diagnostic imaging / Q000235:genetics* / Q000503:physiopathology; D011446:Prospective Studies; D011859:Radiography
D007334:Insulin-Like Growth Factor I