Polymerase chain reaction analysis of the Y chromosome long arm in azoospermic patients: lack of the Y chromosome recognition motif (YRRM1) gene.
We analyzed DNA from a patient with azoospermia whose Y chromosome was cytogenetically normal. A total of 16 loci on the Y chromosome long arm were examined: 15 loci between DYS7E and DYZ1, and the Y chromosome RNA recognition motif (YRRM1) locus, a candidate gene for the azoospermic factor AZF. We did not detect the YRRM1 gene in this patient. This finding supports the theory that YRRM1 is an essential gene for spermatogenesis.
Baba
K
K
Department of Urology, St. Marianna University School of Medicine, Kawasaki, Japan.
Iwamoto
T
T
Nakagome
Y
Y
Kuroki
Y
Y
Nakahori
Y
Y
Yajima
M
M
Tanaka
H
H
Osada
T
T
D000328:Adult; D001706:Biopsy; D004247:DNA / Q000032:analysis*; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D008297:Male; D009154:Mutation; D009687:Nuclear Proteins; D009845:Oligospermia / Q000097:blood / Q000235:genetics* / Q000473:pathology; D016133:Polymerase Chain Reaction; D016601:RNA-Binding Proteins / Q000097:blood / Q000235:genetics*; D012729:Sex Chromosome Aberrations; D013091:Spermatogenesis / Q000235:genetics; D014998:Y Chromosome
D005819:Genetic Markers; D009687:Nuclear Proteins; C501499:RBMY1A1 protein, human; D016601:RNA-Binding Proteins; D004247:DNA