Discovery of a novel, potent, and orally active nonpeptide antagonist of the human luteinizing hormone-releasing hormone (LHRH) receptor.
Cho
N
N
Discovery Research Division, Takeda Chemical Industries, Ltd., 10 Wadai Tsukuba, Ibaraki 300-4293, Japan.
Harada
M
M
Imaeda
T
T
Imada
T
T
Matsumoto
H
H
Hayase
Y
Y
Sasaki
S
S
Furuya
S
S
Suzuki
N
N
Okubo
S
S
Ogi
K
K
Endo
S
S
Onda
H
H
Fujino
M
M
D000818:Animals; D016466:CHO Cells; D003001:Cloning, Molecular; D006224:Cricetinae; D006801:Humans; D066298:In Vitro Techniques; D007986:Luteinizing Hormone / Q000037:antagonists & inhibitors / Q000097:blood; D008252:Macaca fascicularis; D008297:Male; D008958:Models, Molecular; D010903:Pituitary Gland, Anterior / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011966:Receptors, LHRH / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D011728:Pyridones; D011966:Receptors, LHRH; D013876:Thiophenes; D007986:Luteinizing Hormone; C115419:T 98475