Myelin basic protein-like material in the urine of multiple sclerosis patients: relationships to clinical and neuroimaging changes.
Urinary myelin basic protein-like material (MBPLM) represents material which is cross-reactive with a cryptic epitope in peptide 84-89 of human myelin basic protein. While normally present at moderate levels in the adult, these levels rise higher in patients who have secondary progressive multiple sclerosis (MS). The increase in urine MBPLM correlates with the burden of disease detected by T2-weighted cranial magnetic resonance imaging. There is no correlation between urinary MBPLM and acute disease activity in relapsing-remitting MS. The first major need for improving the clinical utility of measurements of MBPLM in urine in MS patients is to delineate its exact chemical features so that assays may be improved and a potential biological role of the MBPLM better understood. The second major task is to apply the group data accumulated and apply them to individual patients. This could prove to be means to individually direct treatment and determine its effectiveness.
Department of Neurology, University of Alabama at Birmingham, USA.
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Whitaker
D000328:Adult; D001826:Body Fluids / Q000737:chemistry; D003429:Cross Reactions; D000939:Epitopes / Q000276:immunology; D006801:Humans; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000652:urine*; D004676:Myelin Basic Protein / Q000652:urine*
D000939:Epitopes; D004676:Myelin Basic Protein