[The evaluation of the efficacy of preventing postoperative pancreatitis in stomach cancer patients by using izoptin and a prolonged peridural lidocaine block].
Efficacy of postoperative pancreatitis prevention is assessed in 123 patients with gastric cancer. Pancreatic bloodflow and central hemodynamics were assessed by rheography, activities of serum amylase and free-radical oxidation by biochemiluminescence of blood plasma. After radical surgery on the stomach, disorders of hemocirculation develop in the pancreas, leading to ischemia of the organ and formation of venous congestion; free-radical oxidation is activated and fermenturia increases. Prolonged epidural blocking with lidocaine prevented a decrease of arterial inflow to the pancreas, decreased the intensity of free-radical oxidation, and was more effective than isoptin therapy.
S V
SV
Kursov
A A
AA
Khizhniak
D000328:Adult; D000368:Aged; D000779:Anesthetics, Local; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008012:Lidocaine; D008875:Middle Aged; D009407:Nerve Block / Q000379:methods*; D010179:Pancreas / Q000098:blood supply / Q000187:drug effects; D010195:Pancreatitis / Q000517:prevention & control*; D011182:Postoperative Care / Q000379:methods*; D011183:Postoperative Complications / Q000517:prevention & control*; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000150:complications* / Q000503:physiopathology / Q000601:surgery; D013997:Time Factors; D014665:Vasodilator Agents / Q000627:therapeutic use*; D014700:Verapamil / Q000627:therapeutic use*
D000779:Anesthetics, Local; D002121:Calcium Channel Blockers; D014665:Vasodilator Agents; D008012:Lidocaine; D014700:Verapamil
Otsenka éffektivnosti profilaktiki posleoperatsionnogo pankreatita u bol'nykh rakom zheludka pri primenenii izoptina i dlitel'noĭ peridural'noĭ blokady lidokainom.