[Effect of primaquine on the elimination of sexual forms of Plasmodium falciparum in vivo].
A study was made on 49 patients, carriers of sexual forms of Plasmodium falciparum, verified through thick smear tests, who received 45 and 90 mg of primaquine base in different schedules selected at random. None of the employed schedules proved better than the traditional one of 45 mg base in a unique dose, although the schedule of 45 mg on the first and third days showed a slight reduction of the time of elimination of the parasitemia. Thus, further studies are recommended. No other factors showed an influence on the time of elimination of the parasitemia.
Instituto de Medicina Tropical Pedro Kouri.
R L
RL
Menéndez Capote
A U
AU
López Chávez
D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000469:parasitology; D018512:Parasitemia / Q000188:drug therapy*; D010963:Plasmodium falciparum / Q000187:drug effects*; D011319:Primaquine / Q000008:administration & dosage / Q000627:therapeutic use*
D000962:Antimalarials; D011319:Primaquine
Efecto de la primaquina sobre la eliminación de las formas sexuadas de Plasmodium falciparum in vivo.