Experimental infection of inbred mouse strains with Spironucleus muris.
Four inbred mouse strains: BALB/c ByJ, 129/J, C3H/HeJ, and DBA/lJ, differing in major histocompatibility type, were orally inoculated with 2 x 10(5) infectious cysts of Spironucleus muris. Fecal samples were collected for fecal cyst output prior to infection, and on days 2, 6, 7, 8, 9, 11, 13, 15, and 17 after infection. Following necropsy, formalin-fixed intestinal sections were examined for the presence of trophozoites. On post-inoculation days 6 and 8, mice of the 129/J strain shed significantly (p<0.05) fewer cysts than other strains. This pilot study suggests that major histocompatibility haplotype may influence susceptibility of inbred mouse strains to S. muris.
Department of Veterinary Pathology, School of Veterinary Medicine, Louisiana State University, Baton Rouge 70803, USA. Baker_d@VT8200.vetmed.lsu.edu
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Baker
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Malineni
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Taylor
D000818:Animals; D001391:Azo Compounds / Q000737:chemistry; D004396:Coloring Agents / Q000737:chemistry; D016828:Diplomonadida / Q000276:immunology*; D004198:Disease Susceptibility; D004801:Eosine Yellowish-(YS) / Q000737:chemistry; D005243:Feces / Q000469:parasitology; D005260:Female; D006239:Haplotypes; D007411:Intestinal Diseases, Parasitic / Q000276:immunology / Q000469:parasitology / Q000662:veterinary*; D008285:Major Histocompatibility Complex / Q000502:physiology*; D008297:Male; D008739:Methyl Green / Q000737:chemistry; D051379:Mice; D008815:Mice, Inbred Strains / Q000276:immunology / Q000469:parasitology*; D008819:Mice, Nude; D010270:Parasite Egg Count / Q000662:veterinary; D010865:Pilot Projects; D011528:Protozoan Infections / Q000276:immunology / Q000469:parasitology; D011529:Protozoan Infections, Animal; D012376:Rodent Diseases / Q000276:immunology* / Q000469:parasitology
D001391:Azo Compounds; D004396:Coloring Agents; C017768:trichrome stain; D008739:Methyl Green; D004801:Eosine Yellowish-(YS)