[Induction of long-term depression (with anxiety and fear components) by immunization of rats against pargyline].
The active immunization of albino rats against pargyline (a MAO B inhibitor) induced the formation of antibody to pargyline and results in deep depressive changes and fear. These changes were observed within 6 weeks after the first immunization. Therefore, it opens the possibility to model depression long by exerting the minimum influences. There was also a long-term modulation of craving for alcohol.
I P
IP
Ashmarin
R A
RA
Danilova
M F
MF
Obukhova
M V
MV
Belopol'skaia
D000818:Animals; D001007:Anxiety / Q000209:etiology; D003863:Depression / Q000209:etiology*; D005239:Fear; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000276:immunology*; D010293:Pargyline / Q000276:immunology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014611:Vaccination
D008996:Monoamine Oxidase Inhibitors; D010293:Pargyline
Induktsiia dlitel'nogo sostoianiia depressii (s komponentami trevozhnosti i strakha) immunizatsieĭ krys k pargilinu.