Frequencies of the butyrylcholinesterase K mutation in Brazilian populations of European and African origin.
The frequency of the butyrylcholinesterase K mutation was calculated on the basis of data obtained by polymerase chain reaction primer-introduced restriction analysis (PCR-PIRA). The population sample was composed of 177 Brazilians: 95 whites of predominantly European ancestry and 82 admixed individuals (European and African origin). The frequencies--18.4 +/- 2.8% for whites and 17.1 +/- 2.9% for admixed--did not differ from those previously obtained in North America, Scotland, Japan, and Denmark. The occurrence of the K mutation in Europeans, East Asians, and Africans suggests a relatively old origin for this mutation, and the similar frequencies found in these populations may suggest the operation of selective forces.
Souza
R L
RL
Department of Genetics, Federal University of Paraná, Curitiba, PR, Brazil.
Castro
R M
RM
Pereira
L
L
Freund
A A
AA
Culpi
L
L
Chautard-Freire-Maia
E A
EA
D044383:Black People / Q000235:genetics*; D001938:Brazil; D002091:Butyrylcholinesterase / Q000235:genetics*; D005787:Gene Frequency; D006801:Humans; D009154:Mutation / Q000235:genetics*; D044465:White People / Q000235:genetics*
D002091:Butyrylcholinesterase