Four distinct regions in the auxiliary domain of heterogeneous nuclear ribonucleoprotein C-related proteins.
A 306 amino acid sequence deduced from a rabbit bladder cDNA is 98% identical to the human heterogeneous nuclear ribonucleoprotein (hnRNP) C2. The sequence comparison of the hnRNP C-related proteins reveals four distinct regions in the C-terminal auxiliary domain. The region next to the N-terminal RNA-binding domain is variable in length. Following the variable region, a basic region and a leucine zipper are conserved in all hnRNP C-related proteins including mouse and human Raly. Several Lys-Ser-Gly repeats are present in the basic region of the hnRNP C proteins. The C-terminal region is more divergent between hnRNP C and Raly. Signature sequences and possible functions are proposed for the different regions of the hnRNP C proteins.
Department of Biochemistry and Molecular Biology H171, Pennsylvania State University College of Medicine, Hershey 17033, USA. wjiang@psu.edu
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Bhavanandan
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D016384:Consensus Sequence; D018076:DNA, Complementary / Q000096:biosynthesis* / Q000737:chemistry; D034482:Heterogeneous-Nuclear Ribonucleoprotein Group C; D034441:Heterogeneous-Nuclear Ribonucleoproteins; D008969:Molecular Sequence Data; D012332:RNA, Heterogeneous Nuclear / Q000737:chemistry / Q000235:genetics*; D011817:Rabbits; D012261:Ribonucleoproteins / Q000737:chemistry / Q000235:genetics*; D016415:Sequence Alignment; D001743:Urinary Bladder / Q000378:metabolism*
C439788:C1 HNRNP; D018076:DNA, Complementary; C503635:HNRNPC protein, human; D034482:Heterogeneous-Nuclear Ribonucleoprotein Group C; D034441:Heterogeneous-Nuclear Ribonucleoproteins; C503633:Hnrnpc protein, mouse; D012332:RNA, Heterogeneous Nuclear; D012261:Ribonucleoproteins