[Effect of gonadal hormones on sexual dimorphism in malnutrition substrates].
The environmental effect on growth and sexual dimorphism is mediated by endocrinological dysfunctions. It was shown that malnutrition acts on the hypotalamus-pituitary-glandular axis. An experiment was made in Wistar rats to determine the effect of some gonadic hormones on the functional components of the skull to which sex dimorphism was alterated by a postnatal undernutrition. The effects of these hormones in restoring sexual cranial dimorphism was tested. Four treatments were applied: control, with food intake ad-libitum; undernutrition (50% of the control food intake); undernutrition plus periodic injections of testosterone and estradiol to males and females, respectively and sham-operated animals, which were injected with oil vehicle only. A radiological longitudinal study was performed between 20 and 80 days of postnatal age. The length width and height of the neural and facial components were measured on each radiograph. Data were processed by ANOVA and Mann-Whitney statistical tests were performed by means of the SYSTAT 7.0 statistical package. Results showed that gonadic hormones restored the sexual cranial dimorphism by stimulating (testosterone) or suppressing (estradiol) the growth of the cranial components.
Centro de Investigaciones en Genética Básica y Aplicada (CIGEBA), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata.
A B
AB
Orden
H M
HM
Pucciarelli
M C
MC
Muñe
L M
LM
Guimarey
M E
ME
Villanueva
R R
RR
Rodríguez
E R
ER
Pons
D000704:Analysis of Variance; D000818:Animals; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D008297:Male; D009748:Nutrition Disorders / Q000150:complications*; D011859:Radiography; D051381:Rats; D012727:Sex Characteristics; D012886:Skull / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000187:drug effects; D018709:Statistics, Nonparametric; D013739:Testosterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D013997:Time Factors
D013739:Testosterone; D004958:Estradiol; C004648:testosterone enanthate
Efecto de las hormonas gonadales sobre el dimorfismo sexual en substrato de desnutrición.