[The basement membrane proteins collagen type IV and laminin and the preinvasive reorganization of the stroma in carcinoma in situ of the cervix uteri].
The migration of tumor cells through the basal membrane (BM) is a key event in the cascade of tumor infiltration and metastasizing. The aim of the present study is to investigate BM proteins larniriin and collagen IV in cervical carcinoma in situ and the preinvasive reorganization of the underlying stroriia. 15 worileri with biopsy diagnosis of cancer in situ are studied. The immunohistochemical PAP-reaction on fresh and parafiri sections is used. Light microscopically there are features of characteristic reorganization of the stroma lying under the neoplasia: neocapillarization next to BM and lack of vascular proliferation far away front it; localized swelling and expressed iriflariiriiatory irifiltrate in these regions. The immunolocalization of laminin and collagen type IV is important for the assessment of BM under the intraepithelial cancer.
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Vasilev
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Buzalov
D000328:Adult; D001485:Basement Membrane / Q000378:metabolism / Q000473:pathology; D001706:Biopsy; D002196:Capillaries / Q000378:metabolism / Q000473:pathology; D002278:Carcinoma in Situ / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D002584:Cervix Uteri / Q000098:blood supply / Q000378:metabolism / Q000473:pathology; D003094:Collagen / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007797:Laminin / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology
D007797:Laminin; D003094:Collagen
Izsledvane na bazalnomembranni proteini kolagen tip IV i laminin i predinvazivnoto preustroĭstvo na stromata pri kartsinom in situ na matochnata shiĭka.