An improved synthesis of malonyl-coenzyme A.
A method for the synthesis of [14C]malonyl-Coenzyme A starting with 10 mumol of [14C]malonate is reported. The synthesis is accomplished with yields of 48 +/- 4% (1 sigma, n = 6) using a procedure which does not require the isolation or purification of any intermediates.
Rutkoski
A
A
Department of Chemistry, Miami University, Oxford, Ohio 45056, USA.
Jaworski
J G
JG
D002250:Carbon Radioisotopes; D002854:Chromatography, Paper; D064429:Fatty Acid Synthases / Q000378:metabolism; D008314:Malonates; D008316:Malonyl Coenzyme A / Q000138:chemical synthesis* / Q000302:isolation & purification; D013379:Substrate Specificity
D002250:Carbon Radioisotopes; D008314:Malonates; D008316:Malonyl Coenzyme A; C030290:malonic acid; D064429:Fatty Acid Synthases