[Synthesis and pharmacologic study of 1,5-benzodiazepine-2,4-dithiones and their alkyl derivatives].
From the pharmacodynamic studies of 1,5-benzodiazepine-2,4-dithiones and alkyl derivatives, we can conclude that these products are not toxic at therapeutic dosage. They have sedative, myorelaxant and anxiolytic actions.
Zellou
A
A
Laboratoire de Pharmacologie et de Toxicologie, Faculté de Médecine et de Pharmacie, Rabat Instituts, Maroc.
Cherrah
Y
Y
Essassi
E M
EM
Hassar
M
M
D000478:Alkylation; D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001569:Benzodiazepines; D006993:Hypnotics and Sedatives / Q000138:chemical synthesis / Q000494:pharmacology; D051379:Mice; D009125:Muscle Relaxants, Central / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013871:Thiones / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D014151:Anti-Anxiety Agents; D006993:Hypnotics and Sedatives; D009125:Muscle Relaxants, Central; D013871:Thiones; D001569:Benzodiazepines
Synthèse et étude pharmacologique des 1,5-benzodiazépine-2,4-dithiones et de leurs dérivés alkylés.