Renal impairment as a possible side effect of gabapentin. A single case report.
A bipolar I manic patient was treated successfully by adding gabapentin to perazine and clonazepam. Also initially tolerated well, an increase of creatinine after several weeks of GP (2000 mg) was observed which was reversible after discontinuation of GP. It is suggested that the possibility of renal dysfunction should be kept in mind with the usage of gabapentin.
Psychiatrische Klinik der Universität,München, Deutschland. grunze@psy.med.uni-muenchen.de
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D000085:Acetates / Q000009:adverse effects*; D000328:Adult; D000588:Amines; D018692:Antimanic Agents / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000188:drug therapy; D003509:Cyclohexanecarboxylic Acids; D004359:Drug Therapy, Combination; D000077206:Gabapentin; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced*; D008297:Male; D005680:gamma-Aminobutyric Acid
D000085:Acetates; D000588:Amines; D018692:Antimanic Agents; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin