Dual infective pathology in patients with cryptococcal meningitis.
Coinfection of the nervous system by two distinct nonviral organisms is uncommon and often undiagnosed. Medical teaching emphasizes that a single pathologic process should be sought; however, in the presence of severe immunocompromise this approach may not hold true. We describe seven HIV-1 seropositive patients with cryptococcal meningitis, three of whom had a proven nervous system infection with a second organism: concurrent tuberculous meningitis, a tuberculoma, and the first documented case of cryptococcal meningitis and neurosyphilis.
Silber
E
E
Department of Neurology, Baragwanath Hospital and University of the Witwatersrand, Johannesburg, South Africa.
Sonnenberg
P
P
Koornhof
H J
HJ
Morris
L
L
Saffer
D
D
D017088:AIDS-Related Opportunistic Infections / Q000382:microbiology*; D000328:Adult; D015497:HIV-1; D006801:Humans; D008297:Male; D016919:Meningitis, Cryptococcal / Q000821:virology*; D008875:Middle Aged; D009494:Neurosyphilis / Q000821:virology*; D013019:South Africa; D014375:Tuberculoma / Q000821:virology; D014390:Tuberculosis, Meningeal / Q000821:virology*; D019562:Viral Load