Oxidation of morphine to 2,2'-bimorphine by cylindrocarpon didymum
The oxidation of morphine by whole-cell suspensions and cell extracts of Cylindrocarpon didymum gave rise to the formation of 2, 2'-bimorphine. The identity of 2,2'-bimorphine was confirmed by mass spectrometry and 1H nuclear magnetic resonance spectroscopy. C. didymum also displayed activity with the morphine analogs hydromorphone, 6-acetylmorphine, and dihydromorphine, but not codeine or diamorphine, suggesting that a phenolic group at C-3 is essential for activity.
Institute of Biotechnology, University of Cambridge, Cambridge CB2 1QT, United Kingdom.
PJ
Stabler
NC
Bruce