Changes of renal taurine transport after treatment with triiodothyronine or dexamethasone in amino acid loaded rats.
In adult female anaesthetized rats, the influence of triiodothyronine or dexamethasone on renal amino acid (AA) handling was investigated in taurine (45 mg/100 g b.wt.) loaded animals. Bolus injections of taurine were followed by temporary increase in fractional excretion (FE(AA)) of taurine as well of the endogenous amino acids which were not administered. Under taurine load conditions, triiodothyronine treatment (20 microg/100 g b.wt. for 3 days, i.p. once daily) was followed by a slight stimulation of the renal taurine reabsorption: the increase in FE(taurine) after taurine load was lower than in untreated rats. Dexamethasone (60 microg/100 g b.wt. for 3 days, i.p. once daily) was without significant effect on FE(taurine) in taurine loaded rats. In non taurine loaded rats there was no hormone influence at all. Similarities and differences between the effects of bolus injections of taurine, glutamine, and leucine on the FE(AA) of these three amino acids were compared in detail to further clarify the reason for the increased amino acid reabsorption capacity after pretreatment with triiodothyronine or dexamethasone.
Institute of Pharmacology and Toxicology, Friedrich Schiller University of Jena, Germany. CFLE@mti-n.uni-jena.de
C
C
Fleck
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Langner
D000596:Amino Acids / Q000008:administration & dosage*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D003907:Dexamethasone / Q000494:pharmacology*; D005260:Female; D005919:Glomerular Filtration Rate; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013654:Taurine / Q000494:pharmacology / Q000652:urine*; D014284:Triiodothyronine / Q000494:pharmacology*
D000596:Amino Acids; D014284:Triiodothyronine; D013654:Taurine; D003907:Dexamethasone