HLA-DP-associated susceptibility to the optico-spinal form of multiple sclerosis in the Japanese.
We studied polymorphism of the HLA-DP gene in 46 patients with optico-spinal form (Asian type) multiple sclerosis (MS) showing recurrent opticomyelitis and 46 patients with Western type MS with disseminated central nervous system involvement. We previously reported a significant association between an HLA-DRB1 *1501-DRB5*0101 haplotype and susceptibility to Western type but not Asian type MS. In the present study, we found that the frequencies of DPA1 *0202 and DPB1 *0501 alleles were significantly increased in patients with Asian type MS, as compared with findings in 92 healthy control subjects (91.3% vs 65.2%, P(corr)<0.05 and 89.1% vs 63.0%, P(corr)<0.05 respectively), but not in Western type MS. Our data provide further evidence that Asian and Western type MS are distinct regarding the immunogenetic background.
Department of Neuroscience and Immunology, Kumamoto University Graduate School of Medical Sciences, Honjo, Japan.
H
H
Ito
K
K
Yamasaki
Y
Y
Kawano
I
I
Horiuchi
C
C
Yun
Y
Y
Nishimura
J
J
Kira
D000483:Alleles; D004198:Disease Susceptibility; D005787:Gene Frequency; D006682:HLA-DP Antigens / Q000032:analysis* / Q000235:genetics*; D006801:Humans; D007564:Japan; D009103:Multiple Sclerosis / Q000145:classification / Q000235:genetics* / Q000276:immunology*; D011110:Polymorphism, Genetic
D006682:HLA-DP Antigens