[Inhibition of the multiplication of a Coxsackie A9 strain isolated from a patient with epidemic neuropathy by the interferons alfa and gamma].
We present the results of the in vitro action of alpha and gamma interferons and of Intacglobin and Igegam against the 47/93/IPK (Coxsackie A9) strain isolated from the cerebrospinal fluid of a patient with epidemic neuropathy. The in vitro studies showed that the two interferons inhibited the replication of this agent; they also showed the presence of antibodies to it in the Intacglobin and Igegam. The results attained demonstrated that the use of these compounds could be effective for the treatment of this entity.
Instituto de Medicina Tropical Pedro Kouri.
M G
MG
Guzmán Tirado
M
M
Soler Nodarse
P
P
Más Lago
L
L
Morier Díaz
A
A
Castillo Alvarez
S
S
Resik Aguirre
M
M
Alvarez
G
G
Kouri Flores
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D003384:Coxsackievirus Infections / Q000134:cerebrospinal fluid / Q000453:epidemiology; D003462:Cuba / Q000453:epidemiology; D004770:Enterovirus / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D016898:Interferon-alpha / Q000494:pharmacology*; D007371:Interferon-gamma / Q000494:pharmacology*; D014709:Vero Cells / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D016898:Interferon-alpha; D007371:Interferon-gamma
Inhibición de la multiplicación de la cepa de Coxsackie A9 aislada de un paciente con neuropatía epidémica frente a los interferones alfa y gamma.