Plasma levels of type II phospholipase A2 and nitrite/nitrate in patients with burns.
Type II phospholipase A2 (type II PLA2), nitrite/nitrate (NOx), tumor necrosis factor-alpha (TNF-alpha) and endotoxin were studied in burn patients. Type II PLA2 values and NOx values were both significantly higher in the group that died, the group with shock as a complication and the group with multiple organ dysfunction syndrome (MODS) as a complication, than in the group that survived, the group without shock as a complication and the group without MODS as a complication, respectively. The results suggested that type II PLA2 and nitric oxide (NO) may play a major role in the pathology of burn patients. Significant correlations were found between TNF-alpha and type II PLA2 values and between type II PLA2 and NOx values, suggesting the possibility of involvement in each other's production.
Yamada
Y
Y
Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.
Endo
S
S
Kamei
Y
Y
Minato
T
T
Yokoyama
M
M
Taniguchi
S
S
Nakae
H
H
Inada
K
K
Ogawa
M
M
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002056:Burns / Q000097:blood* / Q000150:complications; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D054501:Group II Phospholipases A2; D006801:Humans; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000097:blood / Q000209:etiology / Q000401:mortality; D009566:Nitrates / Q000097:blood*; D009569:Nitric Oxide / Q000378:metabolism; D009573:Nitrites / Q000097:blood*; D010741:Phospholipases A / Q000097:blood*; D054467:Phospholipases A2; D012772:Shock, Septic / Q000097:blood / Q000150:complications / Q000401:mortality; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D015415:Biomarkers; D009566:Nitrates; D009573:Nitrites; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide; D010741:Phospholipases A; D054501:Group II Phospholipases A2; D054467:Phospholipases A2