[Advance of gene therapy for neurological diseases by direct in vivo gene transfer].
Gene therapy for neurological diseases is a rapidly expanding field in neurosciences. It has been demonstrated that some viral vectors from HSV-1 (herpes simplex virus type 1), Ad (adenovirus) and AAV (adeno-associated virus) can transfer foreign genes into nondividing cell types (including neurons). In addition, physical/chemical methods are also used in direct in vivo gene transfer. The direct gene transfer techniques will open a new way to study neurophysiology, neuropathology and therapy for neurological diseases at molecular level. They will hopefully lead to surprising progress in gene therapy for neurological diseases.
Li
B Y
BY
Institute of Basic Medical sciences, Academy of Military Medical Sciences, Beijing.
Liu
C
C
Wang
H X
HX
D000260:Adenoviruses, Human / Q000235:genetics; D000818:Animals; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D005822:Genetic Vectors; D018259:Herpesvirus 1, Human / Q000235:genetics*; D009422:Nervous System Diseases / Q000628:therapy*