Complement C4B null allele status confers risk for systemic lupus erythematosus in a Spanish population.
Genetic susceptibility to systemic lupus erythematosus (SLE) may vary amongst different populations. In UK patients, genes encoded in the HLA class II (DQA*0501/DRB1*0301) and class III [C4A*Q0 and tumour necrosis factor (TNF) polymorphisms] subregions appear to contribute to disease susceptibility. We have examined HLA-DRB1, C4 and TNF microsatellites in 50 Spanish SLE patients and 48 matched controls. HLA-DRB1*0301 was increased in patients but did not achieve statistical significance (41% vs. 25.5%). C4A*Q0 was not increased in patients, but C4B*Q0 allele frequency was significantly increased compared with the controls (29% vs. 6%; OR: 6.0). TNF c2 microsatellite allele frequency was also increased in SLE patients. The C4B null allele (C4B*Q0) appears to play an important role in SLE susceptibility in the Spanish population.
Unidad de Investigacion, Hospital Central de Asturias, Oviedo, Spain.
M
M
Naves
A H
AH
Hajeer
L S
LS
Teh
E J
EJ
Davies
J
J
Ordi-Ros
P
P
Perez-Pemen
M
M
Vilardel-Tarres
W
W
Thomson
J
J
Worthington
W E
WE
Ollier
D000483:Alleles; D016022:Case-Control Studies; D015935:Complement C4b / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000276:immunology; D008297:Male; D018895:Microsatellite Repeats; D011110:Polymorphism, Genetic; D012307:Risk Factors; D013030:Spain; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C553502:HLA-DRB1*03:01 antigen; D014409:Tumor Necrosis Factor-alpha; D015935:Complement C4b