Efficacy of cyclosporine plus etretinate in the treatment of erythrodermic psoriasis (three case reports).
BACKGROUND
Association of different treatments are often used in erythrodermic psoriasis in order to increase the effectiveness and decrease the incidence of side effects due to single drugs.


METHODS
Three in-patients affected by erythrodermic psoriasis, not responding to cyclosporine, (two patients) and etretinate, (one patient), were treated with the association cyclosporine plus etretinate.


RESULTS
Clinical response was prompt to the combined therapy. The two drugs were tapering off gradually over 6 months; the patients maintained the remission for prolonged period.


CONCLUSIONS
Combined cyclosporine-etretinate therapy may be considered as an effective and well tolerated treatment of erythrodermic psoriasis in patients not responding to monotherapy regimen.
Institute of Dermatology, Ospedale di Cattinara, Trieste, Italy.
F
F
Kokelj
C
C
Plozzer
P
P
Torsello
G
G
Trevisan
D000368:Aged; D016572:Cyclosporine / Q000627:therapeutic use*; D003879:Dermatologic Agents; D005050:Etretinate / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy*; D012867:Skin / Q000187:drug effects / Q000473:pathology; D016896:Treatment Outcome
D003879:Dermatologic Agents; D005050:Etretinate; D016572:Cyclosporine