Pseudotumour of the tongue caused by herpes simplex virus type 2 in an HIV-1 infected immunosuppressed patient.
An HIV-1 infected immunosuppressed patient (CD4+ cell counts: 382 cells/microL; viral load 94,000 copies/mL) with recurrent perianal herpes simplex virus type 2 (HSV-2) infections is described, showing an unusual exophytic tumour resembling a squamous cell carcinoma in the lateral part of the tongue. He also had persistent facial herpes infection, oral candidosis, oral hairy leukoplakia and lymphadenopathy. The presence of HSV-2 was detected by polymerase chain reaction both in smears and in a tissue biopsy taken from the involved tongue area. Treatment with brivudin, a new oral virustatic drug, led to rapid regression of the tumour.
Husak
R
R
Department of Dermatology, University Medical Center Benjamin Franklin, Free University of Berlin, Germany.
Tebbe
B
B
Goerdt
S
S
Wölfer
L U
LU
Zeichardt
H
H
Stöffler-Meilicke
M
M
Orfanos
C E
CE
D017088:AIDS-Related Opportunistic Infections / Q000150:complications*; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D001973:Bromodeoxyuridine / Q000031:analogs & derivatives / Q000627:therapeutic use; D006104:Granuloma, Plasma Cell / Q000188:drug therapy / Q000821:virology*; D015497:HIV-1; D006558:Herpes Genitalis / Q000150:complications*; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D014060:Tongue Diseases / Q000188:drug therapy / Q000821:virology*
D000998:Antiviral Agents; C020235:brivudine; D001973:Bromodeoxyuridine