Kimura's disease associated with ulcerative colitis: detection of IL-5 mRNA expression of peripheral blood mononuclear cells and colon lesion.
Kimura's disease is considered to be a Th2 type allergic reaction based on the presence of eosinophilia and IgE hyperimmunoglobulinemia. We report a 26-year-old Japanese male with this disorder associated with ulcerative colitis. IL-5 is a selective stimulator for the production of eosinophilia and is considered to play an important role in Kimura's disease. IL-5 mRNA from peripheral blood mononuclear cells and the colon lesion were detected by the reverse-transcriptase polymerase chain reaction method, indicating that IL-5 can also be of importance in ulcerative colitis.
Department of Dermatology, University of Tokyo, Japan.
M
M
Sugaya
T
T
Suzuki
A
A
Asahina
K
K
Nakamura
M
M
Ohtsuki
K
K
Tamaki
D000328:Adult; D000796:Angiolymphoid Hyperplasia with Eosinophilia / Q000150:complications* / Q000473:pathology; D003093:Colitis, Ulcerative / Q000150:complications* / Q000473:pathology; D003106:Colon / Q000737:chemistry / Q000473:pathology; D015870:Gene Expression; D006801:Humans; D015848:Interleukin-5 / Q000235:genetics; D007963:Leukocytes, Mononuclear / Q000737:chemistry / Q000166:cytology; D008297:Male; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction
D015848:Interleukin-5; D012333:RNA, Messenger