Preservation of fertility in women undergoing chemotherapy: current approach and future prospects.
OBJECTIVE
Anticancer treatment causes ovarian failure.


METHODS
Some hormones may have a protective effect on the ovary. Cryopreservation (freezing) of oocytes has had very limited success, and therefore, currently its use before chemotherapy is not a feasible option. However, cryopreservation of embryos is possible. Another solution is oocyte donation followed by in vitro fertilization (IVF).


RESULTS
Ovarian cortical slices containing primordial follicles have been cryopreserved successfully. To restore fertility, cryopreserved-thawed tissue taken from cancer patients before therapy could be replanted after recovery. The possible risk of malignancy restoration could be eliminated by obtaining unilaminar follicles from cryopreserved-thawed tissue and growing them in vitro, followed by routine IVF.


CONCLUSIONS
Although women who undergo chemotherapy face limited options for fertility preservation, intensive studies in cryopreservation and in vitro maturation of follicles harbor hope for brighter prospects in the future.
Department of Obstetrics and Gynecology, Rabin Medical Center, Petah Tikva, Israel.
R
R
Abir
B
B
Fisch
A
A
Raz
S
S
Nitke
Z
Z
Ben-Rafael
D000367:Age Factors; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D003276:Contraceptives, Oral / Q000494:pharmacology / Q000627:therapeutic use; D015925:Cryopreservation; D005260:Female; D005298:Fertility / Q000187:drug effects / Q000502:physiology*; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy*; D006080:Ovarian Follicle / Q000502:physiology; D010053:Ovary / Q000187:drug effects / Q000502:physiology* / Q000637:transplantation; D051381:Rats
D003276:Contraceptives, Oral; D007987:Gonadotropin-Releasing Hormone