The relationship between adhesion molecules and neuronal plasticity.
1. It is presently widely assumed that structural reorganization of synaptic architectures subserves the functional gains that define certain neuronal plasticities. 2. While target molecules thought to participate in such morphological dynamics are not well defined, growing evidence suggests a pivotal role for cell adhesion molecules. 3. Herein, brief discussions are presented on (i) the history of how adhesion molecules became implicated in plasticity and memory processes, (ii) the general biology of some of the major classes of such molecules, and (iii) the future of the adhesion molecule/plasticity relationship.
Hoffman
K B
KB
Ancile Pharmaceuticals, La Jolla, California 92037, USA.
D000818:Animals; D015815:Cell Adhesion Molecules / Q000145:classification / Q000502:physiology*; D015816:Cell Adhesion Molecules, Neuronal / Q000502:physiology; D006801:Humans; D016023:Integrins / Q000502:physiology; D039841:Leukocyte L1 Antigen Complex; D017774:Long-Term Potentiation; D008562:Membrane Glycoproteins / Q000502:physiology; D008568:Memory / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D009419:Nerve Tissue Proteins / Q000502:physiology*; D019006:Neural Cell Adhesion Molecules / Q000235:genetics / Q000502:physiology; D009473:Neuronal Plasticity; D012794:Sialic Acids / Q000502:physiology; D013569:Synapses / Q000502:physiology / Q000648:ultrastructure
D015815:Cell Adhesion Molecules; D015816:Cell Adhesion Molecules, Neuronal; D016023:Integrins; D039841:Leukocyte L1 Antigen Complex; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D019006:Neural Cell Adhesion Molecules; D012794:Sialic Acids; C021319:polysialic acid