[Elevation of serum glucose concentration after administration of 5'-AMP to rats and modulation of this process dynamics following single gamma-irradiation at 1 Gy dose].
Injection of exogenic 5'-AMP to rats was accompanied by pronounced and transient adenosinemediated elevation of serum glucose concentration. Both efficiency and duration of the observed hyperglycemic effect were increased within the first week after single whole-body gamma-irradiation (137Cs) of the animals at 1 Gy dose. These data suggest modification of purinergic regulation of some processes of carbohydrate metabolism and disturbance of the organism tolerance towards the glucose following 1 Gy gamma-irradiation.
Institute of Radiobiology, Academy of Sciences of Belarus, Minsk.
V V
VV
Koltun
G G
GG
Egutkin
G G
GG
Gatsko
D000249:Adenosine Monophosphate / Q000008:administration & dosage*; D000818:Animals; D001786:Blood Glucose / Q000032:analysis* / Q000528:radiation effects*; D008297:Male; D011829:Radiation Dosage; D051381:Rats; D014916:Whole-Body Irradiation
D001786:Blood Glucose; D000249:Adenosine Monophosphate
Povyshenie kontsentratsii gliukozy v krovi krys posle vvedeniia 5'-AMP i izmeneniie dinamiki étogo protsessa pod deĭstviem odnokratnogo gamma-oblucheniia v doze 1 Gr.