The pathogenesis of psoriasis and the mechanism of action of tazarotene.
The 3 major features of psoriasis--abnormal differentiation of keratinocytes, hyperproliferation of keratinocytes, and infiltration of inflammatory components into the skin--can be quantified by measuring levels of certain biochemical markers. Psoriasis is associated with upregulation or downregulation of several of these markers. Tazarotene helps to normalize the levels of the markers, thereby bringing about clinical improvement.
Duvic
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MD Anderson Cancer Center, and Department of Dermatology, University of Texas Medical School, Houston 77030, USA.
Asano
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AT
Hager
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Mays
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D000279:Administration, Cutaneous; D015415:Biomarkers; D004815:Epidermal Growth Factor / Q000378:metabolism; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism; D007641:Keratolytic Agents / Q000494:pharmacology*; D009539:Nicotinic Acids / Q000494:pharmacology*; D011565:Psoriasis / Q000378:metabolism* / Q000473:pathology*; D012176:Retinoids
D015415:Biomarkers; D004815:Epidermal Growth Factor; D007641:Keratolytic Agents; D009539:Nicotinic Acids; C086827:tazarotene; D012176:Retinoids