HIV-1: fifteen proteins and an RNA.
Human immunodeficiency virus type 1 is a complex retrovirus encoding 15 distinct proteins. Substantial progress has been made toward understanding the function of each protein, and three-dimensional structures of many components, including portions of the RNA genome, have been determined. This review describes the function of each component in the context of the viral life cycle: the Gag and Env structural proteins MA (matrix), CA (capsid), NC (nucleocapsid), p6, SU (surface), and TM (transmembrane); the Pol enzymes PR (protease), RT (reverse transcriptase), and IN (integrase); the gene regulatory proteins Tat and Rev; and the accessory proteins Nef, Vif, Vpr, and Vpu. The review highlights recent biochemical and structural studies that help clarify the mechanisms of viral assembly, infection, and replication.
Department of Biochemistry and Biophysics, University of California, San Francisco 94143-0448, USA. frankel@cgl.ucsf.edu
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Frankel
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Young
D005814:Genes, Viral; D015497:HIV-1 / Q000254:growth & development*; D012367:RNA, Viral; D012191:Retroviridae Proteins; D014779:Virus Replication
D012367:RNA, Viral; D012191:Retroviridae Proteins