Histologic changes in the sinus membrane after maxillary sinus augmentation in goats.
OBJECTIVE
Previous studies have reported on the morphologic aspects of bone regeneration after maxillary sinus grafting. However, no previous studies have examinated the morphology of the maxillary sinus mucosa after grafting. The purpose of this study was to evaluate the histologic changes in the lining membrane after sinus augmentation.


METHODS
A unilateral osteotomy of the lateral maxillary wall, medial displacement of the bony segments, and elevation of the sinus mucosa were performed in 12 goats. An autogenous bone graft combined with coralline particles was placed on the floor of the sinus in three animals, and coralline particles alone were placed in three other goats. Six goats were not grafted and were used as controls. Samples were harvested at 2.5, 4.5, and 6.5 months. The maxillary sinus mucosa was examined using light microscopy and scanning and transmission electronic microscopy.


RESULTS
The coralline particles were surrounded by fibrous connective tissue when used alone. The addition of iliac crest bone to the coralline particles stimulated bone formation. After the sinus augmentation, the mucosal lining showed a lack of glands in the lamina propria, and the epithelium showed an increase in goblet cells.


CONCLUSIONS
It was concluded that the sinus mucosa undergoes physiologic adaptations and remains healthy and free of chronic sinusitis after maxillary sinus grafting.
Department of Oral Pathology and Surgery, School of Dentistry, Henri Poincaré University, Nancy, France.
P
P
Bravetti
H
H
Membre
L
L
Marchal
R
R
Jankowski
D000818:Animals; D018786:Bone Substitutes / Q000494:pharmacology; D016025:Bone Transplantation; D002119:Calcium Carbonate / Q000494:pharmacology; D003063:Cnidaria; D005260:Female; D006041:Goats; D008443:Maxillary Sinus / Q000033:anatomy & histology* / Q000601:surgery*; D008854:Microscopy, Electron; D009092:Mucous Membrane / Q000033:anatomy & histology / Q000166:cytology / Q000648:ultrastructure; D013516:Oral Surgical Procedures, Preprosthetic; D010012:Osteogenesis / Q000187:drug effects; D011897:Random Allocation
D018786:Bone Substitutes; D002119:Calcium Carbonate