[Anthrax toxins].
Bacillus anthracis, a Gram positive bacterium, is the causative agent of anthrax. This organism is capsulogen and toxinogenic. It secretes two toxins which are composed of three proteins: the protective antigen (PA), the lethal factor (LF) and the edema factor (EF). The lethal toxin (PA + LF) provokes a subite death in animals, the edema toxin (PA + EF) induces edema. The edema and the lethal factors are internalised into the target cells via the protective antigen. EF and LF exert an adenylate cyclase and a metalloprotease activity respectively. The structure-function relationship of these three proteins were defined using in vitro and in vivo approaches.
Institut Pasteur, Unité toxines et pathogénie bactériennes, Paris.
F
F
Brossier
C
C
Guidi-Rontani
M
M
Mock
D000818:Animals; D000881:Anthrax / Q000382:microbiology; D000942:Antigens, Bacterial; D001408:Bacillus anthracis; D001427:Bacterial Toxins / Q000737:chemistry / Q000633:toxicity; D006801:Humans; D008666:Metalloendopeptidases / Q000737:chemistry
D000942:Antigens, Bacterial; D001427:Bacterial Toxins; C030325:anthrax toxin; D008666:Metalloendopeptidases
Les toxines de Bacillus anthracis.