Fatty acid incorporation depicts brain activity in a rat model of Parkinson's disease.
Following pulse labeling with [3H]arachidonic acid ([3H]AA), its incorporation pattern in brain reflects regional changes in neurotransmitter signal transduction using phospholipase A2, that is, functional activity. In a rat model of Parkinson's disease, unilateral 6-hydroxydopamine lesion in the substantia nigra, [3H]AA acid incorporation from blood was increased in cerebral cortex, caudate putamen, globus pallidus, entopeduncular nucleus, subthalamic nucleus and substantia nigra pars reticulata ipsilateral to the lesion. This increased [3H]AA incorporation likely reflects disinhibition of basal ganglia and cortical circuits secondary to absent inhibitory nigrostriatal dopaminergic input.
Hayakawa
T
T
Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892-1582, USA.
Chang
M C
MC
Bell
J M
JM
Seeman
R
R
Rapoport
S I
SI
Appel
N M
NM
D000818:Animals; D001479:Basal Ganglia / Q000378:metabolism; D001921:Brain / Q000378:metabolism / Q000502:physiology*; D001931:Brain Mapping; D002421:Caudate Nucleus / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D004195:Disease Models, Animal; D005227:Fatty Acids / Q000378:metabolism*; D007839:Functional Laterality / Q000502:physiology; D005917:Globus Pallidus / Q000378:metabolism; D008297:Male; D010302:Parkinson Disease, Secondary / Q000378:metabolism / Q000503:physiopathology*; D010741:Phospholipases A / Q000378:metabolism; D054467:Phospholipases A2; D011699:Putamen / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction / Q000502:physiology*
D005227:Fatty Acids; D010741:Phospholipases A; D054467:Phospholipases A2