Carisoprodol-induced myoclonic encephalopathy.
METHODS
A 39-year-old man ingested 35 g carisoprodol. He developed agitation, tachycardia, myoclonus, and coma. The blood carisoprodol was 71 micrograms/mL; the meprobamate was 26 micrograms/mL.


CONCLUSIONS
Carisoprodol overdose is thought to induce simple central nervous system depression. This case demonstrates a severe overdose with symptoms more consistent with myoclonic encephalopathy. A review of cases presenting to the San Francisco Division of the California Poison Control System during 1997 suggests that carisoprodol is more commonly associated with agitation and bizarre movement disorders than the current literature suggests. The pharmacology and potential mechanisms of toxicity are discussed.


CONCLUSIONS
Agitation, hypertonia, and a myoclonic encephalopathy may be seen with significant carisoprodol intoxication.
California Poison Control System-San Francisco Division, San Francisco General Hospital 94110, USA.
B A
BA
Roth
D R
DR
Vinson
S
S
Kim
D000328:Adult; D017109:Akathisia, Drug-Induced / Q000097:blood; D002328:Carisoprodol / Q000097:blood / Q000506:poisoning*; D003128:Coma / Q000139:chemically induced; D062787:Drug Overdose; D006801:Humans; D008297:Male; D009125:Muscle Relaxants, Central / Q000097:blood / Q000506:poisoning*; D009207:Myoclonus / Q000139:chemically induced*; D013610:Tachycardia / Q000139:chemically induced
D009125:Muscle Relaxants, Central; D002328:Carisoprodol