[Effect of coagulation and fibrinolytic changes on fetal growth in pregnant women with chronic hypertension].
Elevated platelet activation, fibrinogen deposition in microcirculation, elevation of fibrin/fibrinogen degradation products as well as the increase and decrease in factor VIII concentration are described in pregnancies with hypertension. We analyzed data from 31 pregnancies with chronic hypertension. The aim of this study was to evaluate effects on coagulation factors, pregnancy outcome and fetal growth. An evident change in coagulation factors occurred in pregnancies with hypertension in comparison with healthy pregnant women. Statistically significant coefficient correlation between fetal growth and fibrinolysis were obtained (r = 0.3; p < 0.004). With fibrinolysis slowing down a higher birthweight occurred. Birthweight showed correlation with coagulation factor VIII (r = 0.21; p < 0.03).
JU Dom zdravlja, Velika Kladusa.
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Kendić
D000328:Adult; D001724:Birth Weight; D001777:Blood Coagulation; D002908:Chronic Disease; D005314:Embryonic and Fetal Development; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D006973:Hypertension / Q000097:blood*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000097:blood*
Utjecaj koagulacijskih i fibrinolitickih promjena u trudnica s kronicnom hipertenzijom na rast fetusa.