Kindling: separate vs. shared mechanisms in affective disorders and epilepsy.
Kindling is discussed in relation to affective illness as a nonhomologous model, which shares the feature of increasing illness severity and evolution over time following repeated exposures to certain forms of stimulation. This progressive aspect of kindling has proven useful in the study of approaches to pharmacotherapeutics, mechanisms and characteristics of drug tolerance, and, most recently, illness suppression through physiological rather than pharmacological strategies. Each of these themes is described and the mechanisms that have been uncovered using the kindling model are discussed in relation to how similar principles might apply in affective illness or epilepsy. It is hoped that some of the lessons from the kindling model will provide useful and novel insights into aspects of treatment and mechanisms of psychiatric and neurologic illnesses.
Weiss
S R
SR
Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA. SRBW@Sparky.NIMH.NIH.GOV
Post
R M
RM
D000679:Amygdala / Q000187:drug effects / Q000503:physiopathology; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology / Q000627:therapeutic use; D003863:Depression / Q000503:physiopathology; D018450:Disease Progression; D004351:Drug Resistance; D004361:Drug Tolerance / Q000502:physiology; D004827:Epilepsy / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D007696:Kindling, Neurologic / Q000187:drug effects / Q000502:physiology; D008959:Models, Neurological; D019964:Mood Disorders / Q000188:drug therapy / Q000503:physiopathology*; D009433:Neural Inhibition / Q000187:drug effects; D009473:Neuronal Plasticity / Q000187:drug effects
D000927:Anticonvulsants