Biocompatibility of primer, adhesive and resin composite systems on non-exposed and exposed pulps of non-human primate teeth.
OBJECTIVE
To evaluate the histologic response of 332 non-exposed and 127 exposed monkey pulps applying nine adhesive systems.


METHODS
Class V and Class I cavities were used in non-exposed and exposed monkey pulps at the three ISO usage time intervals.


RESULTS
There were no histologic differences in pulp responses among the nine adhesive systems used in either Class V and/or Class I cavities when compared to pulp responses of Ca(OH)2 controls at the ISO time intervals. The nine adhesive systems and resin composites are non-toxic to either non-exposed or exposed pulps, being biologically compatible to pulp tissues when placed on mechanical pulp exposures following hemorrhage control with a 2.5% NaOCl and per manufacturers' directions. It is imperative that clinicians understand the biological importance of hemorrhage control as well as the technique sensitivity of hydrophilic primers in order to optimize the efficacy of adhesives for clinical success against microleakage of bacterial factors.
Department of Restorative Dentistry, School of Dentistry, Birmingham, AL 35294-0007, USA.
C F
CF
Cox
A A
AA
Hafez
N
N
Akimoto
M
M
Otsuki
S
S
Suzuki
B
B
Tarim
D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects; D002126:Calcium Hydroxide / Q000494:pharmacology; D003188:Composite Resins / Q000009:adverse effects; D003782:Dental Pulp / Q000187:drug effects*; D003785:Dental Pulp Capping / Q000009:adverse effects* / Q000379:methods; D003790:Dental Pulp Necrosis / Q000139:chemically induced; D003809:Dentin, Secondary / Q000187:drug effects / Q000254:growth & development; D017220:Dentin-Bonding Agents / Q000009:adverse effects*; D006487:Hemostasis / Q000187:drug effects; D008253:Macaca mulatta; D008422:Materials Testing; D008689:Methacrylates / Q000009:adverse effects; D006472:Oral Hemorrhage / Q000517:prevention & control; D011671:Pulpitis / Q000139:chemically induced
D001672:Biocompatible Materials; D003188:Composite Resins; D017220:Dentin-Bonding Agents; D008689:Methacrylates; D002126:Calcium Hydroxide