Calculation of microplanar beam dose profiles in a tissue/lung/tissue phantom.
Recent advances in synchrotron generated x-ray beams with a high fluence rate permit investigation of the application of an array of closely spaced, parallel or converging microplanar beams in radiotherapy. The proposed technique takes advantage of the hypothesized repair mechanism of capillary cells between alternate microbeam zones, which regenerates the lethally irradiated endothelial cells. The lateral and depth doses of 100 keV microplanar beams are investigated for different beam dimensions and spacings in a tissue, lung and tissue/lung/tissue phantom. The EGS4 Monte Carlo code is used to calculate dose profiles at different depths and bundles of beams (up to 20 x 20 cm square cross section). The maximum dose on the beam axis (peak) and the minimum interbeam dose (valley) are compared at different depths, bundles, heights, widths and beam spacings.
School of Science, University of Western Sydney, Kingswood, NSW, Australia.
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Company
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Allen
D000818:Animals; D055592:Biophysical Phenomena; D001703:Biophysics; D002196:Capillaries / Q000293:injuries / Q000502:physiology / Q000528:radiation effects; D004730:Endothelium, Vascular / Q000293:injuries / Q000502:physiology / Q000528:radiation effects; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy*; D009010:Monte Carlo Method; D019047:Phantoms, Imaging; D017785:Photons / Q000627:therapeutic use; D011880:Radiotherapy Planning, Computer-Assisted; D012038:Regeneration; D012867:Skin / Q000098:blood supply / Q000293:injuries / Q000528:radiation effects