Dopamine D2 receptor density and personal detachment in healthy subjects.
OBJECTIVE
The purpose of this study was to examine the relationship between the personality trait involving personal detachment and dopamine D2 receptor specific binding in healthy subjects.


METHODS
Eighteen adult subjects completed the Karolinska Scales of Personality and the Tridimensional Personality Questionnaire and participated in a study that used [11C]raclopride positron emission tomography (PET) to quantify striatal D2 receptor binding.


RESULTS
A significant relationship was found between D2 receptor specific binding and detachment scores on the Karolinska Scales of Personality but not between D2 receptor specific binding and attachment scores on the Tridimensional Personality Questionnaire. In an exploratory analysis, the authors found a significant relationship between binding and the sentimentality cluster on the Tridimensional Personality Questionnaire but on no other personality clusters scores on the Tridimensional Personality Questionnaire or Karolinska Scales of Personality.


CONCLUSIONS
These findings replicate those of a recent report that personal detachment scores on the Karolinska Scales of Personality are related to dopamine D2 receptor density and extends this finding by suggesting that the relationship is relatively specific to the trait defined by the Karolinska Scales of Personality and does not generalize to other forms of detachment.
Experimental Therapeutics Branch, NIMH, Bethesda, MD, USA. breier_alan@Lilly.com
A
A
Breier
L
L
Kestler
C
C
Adler
I
I
Elman
N
N
Wiesenfeld
A
A
Malhotra
D
D
Pickar
D000328:Adult; D002250:Carbon Radioisotopes; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000378:metabolism; D018492:Dopamine Antagonists; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D010551:Personality / Q000502:physiology*; D010552:Personality Assessment / Q000706:statistics & numerical data; D020891:Raclopride; D017448:Receptors, Dopamine D2 / Q000378:metabolism / Q000502:physiology*; D012457:Salicylamides; D014055:Tomography, Emission-Computed
D002250:Carbon Radioisotopes; D018492:Dopamine Antagonists; D017448:Receptors, Dopamine D2; D012457:Salicylamides; D020891:Raclopride