A prospective controlled study of the association of Streptococcus bovis with colorectal carcinoma.
OBJECTIVE
To investigate the ability of Streptococcus bovis to colonise colorectal cancers.


METHODS
19 patients with colorectal cancer and 23 controls without malignancy.


METHODS
University teaching hospital.


METHODS
Prospective study comparing unselected patients with known colorectal cancer with age and sex matched controls. Carcinoma tissue from patients with colorectal cancer and normal colonic mucosa, stool, and blood from both patients and control subjects were cultured.


RESULTS
In contrast to published data, the faecal carriage rate was similar in cancer (11%) and control groups (13%).


CONCLUSIONS
Faecal colonisation by Str bovis in colorectal cancer patients is lower than previously reported and does not differ significantly from controls.
Potter
M A
MA
University of Edinburgh Department of Surgery, Western General Hospital, UK. map@srv0.med.ed.ac.uk
Cunliffe
N A
NA
Smith
M
M
Miles
R S
RS
Flapan
A D
AD
Dunlop
M G
MG
D000230:Adenocarcinoma / Q000382:microbiology*; D000236:Adenoma / Q000382:microbiology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000382:microbiology*; D005243:Feces / Q000382:microbiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016985:Streptococcus bovis / Q000472:pathogenicity*