Demethyl mutactimycins, new anthracycline antibiotics from Nocardia and Streptomyces strains.
New anthracycline antibiotics 3'-O-demethyl mutactimycin (3) and 4-O,3'-O-didemethyl mutactimycin (4) were isolated from two actinomycetes strains, Nocardia transvalensis and Streptomyces sp. GW 60/1571. The chemical structures were elucidated by mass spectrometry and NMR spectroscopy. Antibiotic 3 displayed moderate antimicrobial activity against Gram-positive bacteria and cytotoxicity against P388, L1210 and HeLa tumor cells (IC50; 9.6, >25 and 20 microg/ml, respectively).
Institute of Organic Chemistry, Göttingen, Germany.
M
M
Speitling
P
P
Nattewan
K
K
Yazawa
Y
Y
Mikami
I
I
Grün-Wollny
M
M
Ritzau
H
H
Laatsch
U
U
Gräfe
D000818:Animals; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005285:Fermentation; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D007939:Leukemia L1210 / Q000188:drug therapy; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009615:Nocardia; D013237:Stereoisomerism; D013302:Streptomyces; D013329:Structure-Activity Relationship
C114876:3'-O-demethyl mutactimycin; C114875:4-O,3'-O-didemethyl mutactimycin; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic