Intestinal fat suppressed intake of fat longer than intestinal sucrose.
Although animals eventually stop eating when only experiencing the oro-sensory stimuli from a food, they stop eating much more rapidly if they also receive postgastric stimuli simultaneously. This suggests that the postgastric effects of a nutrient influence the hedonic value of food or motivation to consume that food, and thus, can influence food selection within the time frame of a meal. In this experiment, rats were equipped with a gastric fistula and duodenal cannula. This combination allowed them to receive the same oro-sensory stimuli, but different postgastric nutrients. While ingesting either a fat (Intralipid) or carbohydrate (sucrose) solution, both of which drained from the gastric fistula, the rats received a duodenal infusion of either sucrose (10 mLs, 0.24 kcals/mL), fat (10 mLs, 0.25 kcals/mL) or saline (10 mLs, 0 kcals/mL). While ingesting the Intralipid, a duodenal infusion of fat suppressed intake quicker and longer than an infusion of sucrose. While the animals ingested sucrose, sucrose and fat suppressed intake equivalently.
Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan 66506, USA. foster@vet.ksu.edu
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D000818:Animals; D003864:Depression, Chemical; D004041:Dietary Fats / Q000378:metabolism / Q000494:pharmacology*; D019422:Dietary Sucrose / Q000378:metabolism / Q000494:pharmacology*; D004386:Duodenum / Q000378:metabolism; D005247:Feeding Behavior / Q000187:drug effects*; D005753:Gastric Mucosa / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism*; D007441:Intubation, Gastrointestinal; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013270:Stomach / Q000502:physiology; D013997:Time Factors
D004041:Dietary Fats; D019422:Dietary Sucrose