[The effect of rudotel on the synaptic activity of dopaminergic neurons].
The work discusses the neurochemical correlates of rat brain dopamin-synaptic activity after injection of 0.5 mg/kg rudotel (medazepam) as compared with intact animals. The parameters of functioning of D2-receptors in [3H]-dopamine binding, the content of catecholamines and their metabolites (high-performance liquid chromatography with electrochemical detection) were studied in the dopaminergic system in different brain areas (the striatum, frontal cortex, amygdala, hippocampus, hypothalamus, and accumbence).
Institute of Inorganic Chemistry, Siberian Branch, Academy of Sciences, Novosibirsk, Russia.
E K
EK
Podgornaia
O V
OV
Galkina
R Iu
RIu
Il'iuchenok
O V
OV
Poliakov
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D002395:Catecholamines / Q000378:metabolism; D008297:Male; D008472:Medazepam / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D011954:Receptors, Dopamine / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*
D014151:Anti-Anxiety Agents; D002395:Catecholamines; D011954:Receptors, Dopamine; D008472:Medazepam
Vliianie rudotelia na sinapticheskuiu aktivnost' dofaminergicheskikh neĭronov.