An accessory peptide binding site with allosteric effect on the formation of peptide-MHC-II complexes?
MHC-II molecules bind a single peptide in their groove. Here, the authors summarise evidence that a second peptide could bind transiently to MHC-II molecules outside the groove and have an allosteric effect on peptide-MHC-II complex formation. This effect could modulate, after the antigen processing, the selection of the peptide subset presented by MHC-II molecules to the helper CD4 T cells, which regulate the specific immune response.
Gerlier
D
D
Immunité et infections virales, IVMC, CNRS-UCBL, Lyon, France. gerlier@cimac-res.univ-lyon1.fr
Trescol-Biémont
M C
MC
Ettouati
L
L
Paris
J
J
Rabourdin-Combe
C
C
D000494:Allosteric Regulation; D000595:Amino Acid Sequence; D000818:Animals; D017951:Antigen Presentation; D001665:Binding Sites; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D008969:Molecular Sequence Data; D010455:Peptides / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D000949:Histocompatibility Antigens Class II; D010455:Peptides