Effects of Coriolus versicolor polysaccharides on superoxide dismutase activities in mice.
OBJECTIVE
To study if Coriolus versicolor polysaccharides (CVP) influence the superoxide dismutase (SOD) activities in mice.


METHODS
Normal, tumor-bearing, and radiated ICR mice were injected ip with CVP daily for 3-15 d. The SOD activity was assayed by epinephrine autoxidation test.


RESULTS
The SOD activities in lymphocytes and thymus were increased by CVP in both the normal mice with or without delayed hypersensitivity (DH). In tumor-bearing mice, CVP exerted not only inhibitory effects on tumor, growth and SOD activity in tumor tissue but also complete or partial restorative effects on the suppressed DH and on the declined SOD activities in lymphocytes, spleen, and thymus. The total SOD and manganese-containing SOD (MnSOD) activities in lymphocytes and thymus were dose-dependently enhanced by CVP (5-20 mg.kg-1) on d 3 after the tumor transplantation. In the mice exposed to 60Co (3 or 6 Gy), DH and SOD activities were dose-dependently decreased. These changes were completely or partly prevented by CVP.


CONCLUSIONS
CVP exerted the favorable effects on SOD activities in mice. Coriolus versicolor polysaccharides (CVP) exert inhibitory effects on experimental and clinical tumors. These effects are presumed to be mediated mainly by host-defence mechanism, especially immunological responeses. Superoxide dismutase (SOD) plays an important role in protecting cells against superoxide radical (O2-.) damages and over-production of O2-. or SOD abnormities exist in many diseases. The present study was to investigate if the CVP could exert some favorable effects on SOD activities in vivo.
Wei
W S
WS
Department of Pharmacology, Second Military Medical University, Shanghai, China.
Tan
J Q
JQ
Guo
F
F
Ghen
H S
HS
Zhou
Z Y
ZY
Zhang
Z H
ZH
Gui
L
L
D000818:Animals; D001487:Basidiomycota / Q000737:chemistry; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D005260:Female; D006968:Hypersensitivity, Delayed / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009368:Neoplasm Transplantation; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology; D011509:Proteoglycans / Q000494:pharmacology*; D011833:Radiation Injuries, Experimental / Q000378:metabolism; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism*
D011134:Polysaccharides; D011509:Proteoglycans; D011837:Radiation-Protective Agents; C010770:polysaccharide-K; D013482:Superoxide Dismutase