Free light chains in multiple sclerosis urine.
We measured free kappa (kappa) and lambda (lambda) light chains in urine from patients with definite multiple sclerosis (MS), other neurologic diseases (OND), and normal controls by using an enzyme linked immunosorbent assay. Both kappa and lambda light chains were higher in MS than OND or controls. In seven of eight relapsing-remitting (R-R) MS patients serial studies showed that urinary kappa chains were elevated during periods of worsening, and decreased during clinical recovery. In contrast, the levels of kappa chains did not correlate with clinical activity in 10 progressive (P) MS patients. Further correlation of urinary light chains with neurologic evaluations in R-R and P MS patients over a longer period are needed to determine their clinical and biological relevance.
Department of Immunology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314-6399, USA.
P D
PD
Mehta
S D
SD
Cook
P K
PK
Coyle
R A
RA
Troiano
C S
CS
Constantinescu
A M
AM
Rostami
D015415:Biomarkers / Q000652:urine; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000652:urine*; D007146:Immunoglobulin lambda-Chains / Q000652:urine*; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000276:immunology / Q000652:urine; D011237:Predictive Value of Tests
D015415:Biomarkers; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains