Effect of Pichia anomala killer toxin on Candida albicans.
The effect of a Pichia anomala killer toxin upon a Candida albicans-sensitive strain was studied. Yeast and hyphae, after treatment with the toxin, were less capable of uptaking either [3H]-uridine or [35S]-methionine. In addition, the hyphal form of the fungus appeared to be less capable of DNA synthesis after toxin treatment. No effect of the killer toxin was shown upon a natural resistant mutant of the source strain. These data suggest that, similar to other killer yeast toxins, the toxin of P. anomala can produce a number of quantifiable effects upon sensitive C. albicans cells.
Department of Microbiology and Immunology, Loyola University of Chicago, Maywood, IL, USA.hmathew@wpo.it.luc.edu
H L
HL
Mathews
S
S
Conti
L
L
Witek-Janusek
L
L
Polonelli
D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D002455:Cell Division / Q000187:drug effects; D004271:DNA, Fungal / Q000096:biosynthesis; D008715:Methionine / Q000378:metabolism; D009183:Mycotoxins / Q000494:pharmacology*; D010843:Pichia; D014529:Uridine / Q000378:metabolism
D004271:DNA, Fungal; D009183:Mycotoxins; D008715:Methionine; D014529:Uridine