Olanzapine augmentation of clozapine.
In clinical practice, patients are encountered who are partial responders or nonresponders to clozapine. There are others who are unable to tolerate a high dosage of clozapine. In the two cases presented, we propose an alternative strategy using olanzapine in combination with clozapine in treatment-refractory patients. Olanzapine was found to be helpful in these patients, however, controlled studies are needed.
Gupta
S
S
SUNY Health Science Center at Syracuse, New York, USA.
Sonnenberg
S J
SJ
Frank
B
B
D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001569:Benzodiazepines; D003024:Clozapine / Q000008:administration & dosage* / Q000494:pharmacology; D004347:Drug Interactions; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077152:Olanzapine; D010890:Pirenzepine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D012559:Schizophrenia / Q000188:drug therapy*; D016896:Treatment Outcome
D014150:Antipsychotic Agents; D001569:Benzodiazepines; D010890:Pirenzepine; D003024:Clozapine; D000077152:Olanzapine