[Pathogenic power of Salmonellae: virulence factors and study models].
Salmonellae are potentially pathogenic for humans as well as for numerous animal species. They possess numerous virulence factors, which allow them to adapt to various environmental conditions and to host response at each step of the pathogenic process. Key-steps such as the invasion of epithelial cells or survival within macrophages have been extensively studied. These studies have led to the discovery of an original protein secretion system and have demonstrated the existence of pathogenicity islands. This considerable progress is due to the development of numerous in vitro and in vivo models and of new identification strategies for the implicated genes. Recently, many original and elegant strategies have been recently proposed.
Laboratoire d'écopathologie microbienne, centre de recherche Inra de Tours, Nouzilly, France. millemann@vet-alfort.fr
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Millemann
D000818:Animals; D006801:Humans; D012475:Salmonella / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology*; D012480:Salmonella Infections / Q000503:physiopathology; D012481:Salmonella Infections, Animal / Q000503:physiopathology; D014774:Virulence / Q000502:physiology*
Le pouvoir pathogène des salmonelles: facteurs de virulence et modèles d'étude.