Intraventricular hemorrhage: emphasis on prevention.
Germinal matrix/intraventricular hemorrhage is a common type of cerebral injury in premature newborns. Based on the improved understanding of underlying pathogenetic mechanisms, numerous interventional strategies for prevention have been proposed. This article summarizes and evaluates the efficacy and safety of major interventions that are currently under consideration for the prevention of germinal matrix/intraventricular hemorrhage.
Hill
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Department of Pediatrics, University of British Columbia, British Columbia's Children's Hospital, Vancouver, Canada.
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000933:Antifibrinolytic Agents / Q000627:therapeutic use; D001778:Blood Coagulation Disorders / Q000188:drug therapy; D002543:Cerebral Hemorrhage / Q000175:diagnosis / Q000517:prevention & control*; D002552:Cerebral Ventricles; D004979:Ethamsylate / Q000627:therapeutic use; D006490:Hemostatics / Q000627:therapeutic use; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use; D007231:Infant, Newborn; D011295:Prenatal Care; D012307:Risk Factors; D014148:Tranexamic Acid / Q000627:therapeutic use; D014810:Vitamin E / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000933:Antifibrinolytic Agents; D006490:Hemostatics; D014810:Vitamin E; D004979:Ethamsylate; D014148:Tranexamic Acid; D007213:Indomethacin