Posttreatment with propofol terminates lidocaine-induced epileptiform electroencephalogram activity in rabbits: effects on cerebrospinal fluid dynamics.
There are no controlled studies to determine whether propofol given after the onset of lidocaine-induced seizures (posttreatment) stops lidocaine-induced seizures. In this study, we determined whether posttreatment with propofol abolishes lidocaine-induced epileptiform electroencephalogram (EEG) activity as effectively as does midazolam, and cerebrospinal fluid (CSF) dynamics during lidocaine-induced epileptiform EEG activity and its treatment. EEG activity and CSF dynamics were determined in two groups of anesthetized rabbits at each of four experimental conditions: baseline, lidocaine-induced epileptiform activity, treatment with midazolam (n = 6) or propofol (n = 6), and return to baseline. The analog EEG signal was converted into a set of digital parameters using aperiodic analysis, and CSF dynamics were determined using ventriculocistemal perfusion. Propofol (3.8 +/- 1.3 mg/kg) stopped epileptiform activity, as did midazolam (2.0 +/- 1.7 mg/kg). The rates of CSF formation or reabsorption and resistances to CSF reabsorption or flow at the arachnoid villi did not differ among conditions or between groups. Our results indicate that propofol and midazolam both terminate epileptiform activity without changing CSF dynamics.


CONCLUSIONS
Propofol may be an alternative to benzodiazepines for treating lidocaine-induced epileptiform electroencephalogram activity in patients.
Department of Anesthesiology, University of Washington School of Medicine, Seattle 98195-6540, USA.
Y
Y
Momota
A A
AA
Artru
K M
KM
Powers
D S
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Mautz
Y
Y
Ueda
D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D000779:Anesthetics, Local / Q000633:toxicity*; D000818:Animals; D002555:Cerebrospinal Fluid / Q000187:drug effects / Q000502:physiology*; D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced* / Q000188:drug therapy*; D008012:Lidocaine / Q000633:toxicity*; D008874:Midazolam / Q000008:administration & dosage; D015742:Propofol / Q000008:administration & dosage*; D011817:Rabbits
D018686:Anesthetics, Intravenous; D000779:Anesthetics, Local; D008012:Lidocaine; D008874:Midazolam; D015742:Propofol