Microscopic observations on livers of rabbits and dogs infected with Schistosoma japonicum cercariae and early treatment with artemether or praziquantel.
To study the histopathological change of the liver of the hosts treated with artemether (Art) or praziquantel (Pra) in early stage after infection with Schistosoma japonicum cercariae.


METHODS
Dogs infected once with schistosome cercariae were treated ig with Art 10 mg.kg-1 or Art capsule (ArtC) 15 mg.kg-1 on d 7, or praziquantel (Pra) 30-40 mg.kg-1 on d 21 after infection, followed by the repeated dosing once every 1 or 2 wk for 2-4 times. In rabbits, infected with 48-52 schistosome cercariae once every other day for 5 times, were treated ig with Art 10 mg.kg-1 or Pra 30 mg.kg-1 was started on d 7 or on d 21 after the first infection, followed by the repeated dosing every 1 or 2 wk for 2-3 times.


RESULTS
After above mentioned dogs or rabbits were treated ig with Art, ArtC or Pra, the female worm reduction rates were 92.1%-100%. Histopathological examination showed that the reduction rates of total granuloma in the liver sections of the dogs and rabbits were 70.9%-97.3% and 76.5%-97.4%, respectively. Meantime, the structure of the hepatic lobules was normal with normal arrangement of the liver bundle.


CONCLUSIONS
Early treatment with Art or Pra exhibited a promising effect of protection of the liver of the dogs and rabbits infected with schistosome cercariae. Early treatment of infection with schistosome cercariae kills the Female worms before oviposition. Thus, the host will be protected from the damage caused by schistosome eggs. Promising results were obtained when mice and rabbits received an early treatment with artemether (Art) or praziquantel (Pra). This work was to study the liver infected with cercariae and treated by intragastric gavage (ig) with Art, Art capsule (ArtC) or Pra in early stage after infection.
Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis, Shanghai, China.
S H
SH
Xiao
Y Q
YQ
Yang
C W
CW
Zhang
J Q
JQ
You
D000818:Animals; D000077549:Artemether; D037621:Artemisinins; D004285:Dogs; D004334:Drug Administration Schedule; D005260:Female; D015745:Granuloma, Foreign-Body / Q000473:pathology; D008099:Liver / Q000473:pathology*; D008297:Male; D011223:Praziquantel / Q000008:administration & dosage*; D011817:Rabbits; D012554:Schistosomiasis japonica / Q000188:drug therapy* / Q000473:pathology; D012556:Schistosomicides / Q000008:administration & dosage; D012717:Sesquiterpenes / Q000008:administration & dosage*
D037621:Artemisinins; D012556:Schistosomicides; D012717:Sesquiterpenes; D011223:Praziquantel; D000077549:Artemether