CD3+CD8+ cell levels as predictors of transmission in human immunodeficiency virus-infected couples: a report from the heterosexual HIV transmission study.
OBJECTIVE
The goal of this study was to identify in human immunodeficiency virus (HIV)-infected individuals immunologic markers that correlated with transmission of HIV by heterosexual contact.


METHODS
In a case-control comparison of couples, immunologic and viral parameters were evaluated in 343 HIV-positive individuals who were members of 67 HIV-seroconcordant couples (both partners HIV positive) and 211 HIV serodiscordant couples (one positive, one negative).


RESULTS
The most striking immunologic finding was the increased numbers of CD3+CD8+ cells found in the index member of discordant couples as compared to the index member of the concordant couples. Differences in CD3+CD8+ levels persisted after adjustment for stage of disease and CD3+CD4+ count. This increase in the number of CD3+CD8+ cells was accompanied by a concomitant decrease in the amount of viral replication measured by both HIV culture endpoint and quantitative RNA polymerase chain reaction (PCR).


CONCLUSIONS
Data presented here further support the role of CD3+CD8+ cells in suppressing or controlling viral activity, although a causal role based on case-control data must be advanced cautiously. This in vivo biologic function may help prevent or lower the risk of HIV transmission.
Denny
T N
TN
Department of Pathology and Laboratory Medicine, and Department of Preventive Medicine and Community Health, UMDNJ-New Jersey Medical School, Newark, New Jersey, USA.
Skurnick
J H
JH
Palumbo
P
P
Perez
G
G
Monel
R
R
Stephens
R
R
Kennedy
C A
CA
Louria
D B
DB
D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D018414:CD8-Positive T-Lymphocytes; D016022:Case-Control Studies; D005260:Female; D005434:Flow Cytometry; D005500:Follow-Up Studies; D016655:HIV Core Protein p24 / Q000097:blood; D019302:HIV Envelope Protein gp160 / Q000097:blood; D015658:HIV Infections / Q000276:immunology* / Q000635:transmission*; D006679:HIV Seropositivity; D006801:Humans; D016130:Immunophenotyping; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012367:RNA, Viral / Q000097:blood
D015415:Biomarkers; D016655:HIV Core Protein p24; D019302:HIV Envelope Protein gp160; D012367:RNA, Viral