Glycosidopyrroles. Part 3. Effect of the benzocondensation on acyclic derivatives: 1-(2-hydroxyethoxy) methylindoles as potential antiviral agents.
The new of 1-(2-hydroxyethoxy)methylindole derivatives 3a-i were prepared in good yields. None of them showed any significant anti-HIV activity and therefore the benzocondensation between the 2 and 3 positions of the pyrrole ring definitely reduced the weak activity found in the analogues 1a-c.
Istituto Farmacochimico, Università degli Studi, Palermo, Italy.
A M
AM
Almerico
P
P
Barraja
P
P
Diana
G
G
Cirrincione
F
F
Mingoia
C
C
Musiu
G
G
Perra
M
M
Putzolu
M E
ME
Marongiu
D000818:Animals; D019380:Anti-HIV Agents / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D002522:Chlorocebus aethiops; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D015497:HIV-1 / Q000187:drug effects / Q000472:pathogenicity; D006801:Humans; D007211:Indoles / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D011758:Pyrroles / Q000737:chemistry* / Q000494:pharmacology; D014709:Vero Cells; D014779:Virus Replication / Q000187:drug effects
D019380:Anti-HIV Agents; D007211:Indoles; D011758:Pyrroles