Synthesis and anticonvulsant activity of some 2-N-(phthalimido)-1-alkyl esters.
Synthesis and physicochemical properties of new 2-N-(phthalimido)-1-alkyl esters are described. Esters were synthesized from aromatic and heterocyclic acids with appropriate bromoalkyl phthalimides in the presence of 1,8-diazabicyclo[5,4,0]-undec-7-ene or triethylamine. The obtained compounds were evaluated for anticonvulsant activity. The display protection against MES and ScMet-induced seizures.
Marona
H
H
Department of Chemical Technology of Drugs, Collegium Medicum, Jagiellonian University, Kraków, Poland.
Kieć-Kononowicz
K
K
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D003292:Convulsants; D004597:Electroshock; D051379:Mice; D010433:Pentylenetetrazole; D010797:Phthalimides / Q000138:chemical synthesis* / Q000494:pharmacology; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*
D000927:Anticonvulsants; D003292:Convulsants; D010797:Phthalimides; D010433:Pentylenetetrazole