Erythropoietin-producing renal cell carcinoma arising from acquired cystic disease of the kidney.
A 49-year-old woman had been on hemodialysis for 18 years. She presented with left back pain and macrohematuria. Radiologic studies demonstrated a left renal tumor with acquired cystic disease of the kidney. Her serum erythropoietin (EPO) level was 78.4 U/L despite no history of EPO supplementation. Left radical nephrectomy was performed. Pathologic examination revealed EPO-producing renal cell carcinoma. After surgery, the patient's serum EPO level decreased markedly to 15.1 U/L. The measurement of serum EPO levels may be useful for detecting and monitoring a recurrence of renal cell carcinoma with acquired cystic disease of the kidney in patients on long-term hemodialysis.
Hanada
T
T
Department of Urology, Oita Medical University, Japan.
Mimata
H
H
Ohno
H
H
Nasu
N
N
Nakagawa
M
M
Nomura
Y
Y
D002292:Carcinoma, Renal Cell / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D004921:Erythropoietin / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D008875:Middle Aged; D009392:Nephrectomy; D007690:Polycystic Kidney Diseases / Q000150:complications* / Q000000981:diagnostic imaging / Q000378:metabolism; D014057:Tomography, X-Ray Computed
D004921:Erythropoietin