Does hyperconcentration result in platelet activation?. A flow-cytometric study of hyperconcentrated random donor platelets.
OBJECTIVE
Hyperconcentration of platelets may lead to platelet activation and loss of platelet function.


METHODS
Platelet activation following hyperconcentration was assessed using flow-cytometric detection of platelet P-selectin expression and platelet swirling.


RESULTS
Platelet hyperconcentration led to a minimal increase in P-selectin expression and no difference in platelet swirling.


CONCLUSIONS
Hyperconcentration was not associated with a clinically significant change in platelet activation and had no significant effect on platelet quality as detected by pH and platelet yield.
Gollehon
T J
TJ
The University of Texas Health Science Center, San Antonio, Tex., USA.
King
D E
DE
Craig
F E
FE
D001792:Blood Platelets / Q000502:physiology*; D002498:Centrifugation; D005434:Flow Cytometry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D019007:P-Selectin / Q000097:blood; D015539:Platelet Activation / Q000502:physiology*; D010976:Platelet Count
D019007:P-Selectin