Effects on the hemostatic system and liver function in relation to Implanon and Norplant. A prospective randomized clinical trial.
In this prospective randomized clinical trial, two long-term contraceptive implants were studied with respect to hemostasis and liver function in 86 healthy young women. The two implants used were Implanon, containing the progestagen etonogestrel (the biologically active metabolite of desogestrel) and Norplant, the implant containing the progestagen levonorgestrel. The results of the trial showed that both implants had similar small effects on the hemostatic system that are not suggestive of a tendency towards thrombosis. The effect on liver function was characterized by increases in total bilirubin and gamma-glutamyl transferase and decreases in alanine aminotransferase and aspartate aminotransferase.
Department of Clinical Chemistry and Blood Coagulation, Karolinska Sjukhuset, Stockholm, Sweden.
N
N
Egberg
A
A
van Beek
C
C
Gunnervik
S
S
Hulkko
E
E
Hirvonen
U
U
Larsson-Cohn
H C
HC
Bennink
D000328:Adult; D003271:Contraceptive Agents, Female / Q000009:adverse effects*; D017135:Desogestrel; D005260:Female; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D016912:Levonorgestrel / Q000009:adverse effects*; D008099:Liver / Q000187:drug effects*; D008111:Liver Function Tests; D045167:Progesterone Congeners / Q000009:adverse effects*; D011446:Prospective Studies; D014753:Vinyl Compounds / Q000009:adverse effects*
D003271:Contraceptive Agents, Female; D045167:Progesterone Congeners; D014753:Vinyl Compounds; C044815:etonogestrel; D016912:Levonorgestrel; D017135:Desogestrel