[Geotrichum capitatum infection in a neutropenic patient. Apropos of a case and review of the literature].
BACKGROUND
Geotrichum capitatum sepsis are rare, occurring exclusively in immunocompromised patients.


METHODS
We report the case of a patient with acute leukemia, presenting with chemotherapy-induced neutropenia and hospitalized in an intensive care unit for a severe sepsis. In spite of an antibiotic and antifungal treatment, the patient died of cardiorespiratory failure. Later on, blood cultures proved to be positive for Geotrichum capitatum.


CONCLUSIONS
If fungal infections are common in neutropenic patients, Geotrichum capitatum sepsis remain exceptional. The portal of entry is digestive or respiratory, and the invasion is favored by immunodepression and suppression of the normal microbial flora. Induced lesions can be multiorganic. The treatment is not well established, and the association of either amphotericine B and 5-fluorocytosine or amphotericine B and itraconazole would lead to better results. Nevertheless, the prognosis is still unfavorable, with a mortality rate of approximately 75%.
Service de réanimation, Centre Jean-Perrin, Clermont-Ferrand, France.
M
M
Fouassier
D
D
Joly
M
M
Cambon
H
H
Peigue-Lafeuille
P
P
Condat
D000208:Acute Disease; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects; D004338:Drug Combinations; D017809:Fatal Outcome; D005437:Flucytosine / Q000627:therapeutic use; D005847:Geotrichosis / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D016867:Immunocompromised Host; D017964:Itraconazole / Q000627:therapeutic use; D007938:Leukemia / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced / Q000473:pathology*; D009894:Opportunistic Infections / Q000175:diagnosis* / Q000188:drug therapy
D000935:Antifungal Agents; D000970:Antineoplastic Agents; D004338:Drug Combinations; D017964:Itraconazole; D000666:Amphotericin B; D005437:Flucytosine
Infection à Geotrichum capitatum chez un patient neutropénique. A propos d'un cas et revue de la littérature.