[A comparative study of the activity of a natural peptide complex in the kidneys and its synthetic analogs in autoimmune nephritis].
The activity of the natural peptide complex of the kidneys and of its synthetic analogs (PEKDLRK, PEKDSRK, PEKDDRL) in autoimmune nephritis was studied on golden hamsters. All the peptides under study demonstrated therapeutic activity but were characterized by peculiarity of their effect. The peptide PEKDLRK possessed the most marked capacity for stimulating phagocytic reactions, PEKDDRL apparently activated the system of natural killers. It is concluded that the study of peptides-analogs as potential drugs is promising.
Geĭko
O A
OA
Ukranian Medical Stomatological Academy, Poltava, Ukraine.
Bobrova
N A
NA
Kaĭdashev
I P
IP
D000818:Animals; D001327:Autoimmune Diseases / Q000097:blood / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D006224:Cricetinae; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005260:Female; D007111:Immunity, Cellular / Q000187:drug effects; D007668:Kidney / Q000473:pathology / Q000502:physiology*; D008297:Male; D008647:Mesocricetus; D009393:Nephritis / Q000097:blood / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D009842:Oligopeptides / Q000627:therapeutic use*; D009929:Organ Size / Q000187:drug effects; D010455:Peptides / Q000627:therapeutic use*
D009842:Oligopeptides; D010455:Peptides; C115480:prolyl-glycyl-lysyl-aspartyl-aspartyl-arginyl-leucine; C115478:prolyl-glycyl-lysyl-aspartyl-leucyl-arginyl-lysine; C115479:prolyl-glycyl-lysyl-aspartyl-seryl-arginyl-lysine
Sravnitel'noe izuchenie aktivnosti estestvennogo peptidnogo kompleksa pochek i ego sinteticheskikh analogov pri autoimmunnom nefrite.