Apoptosis: getting rid of the bodies.
Cells that die by apoptosis need to be removed before lysis to preserve tissue integrity and function. Recent studies have identified components of the uptake machinery used by phagocytes, but much remains to be learnt, particularly about the recognition mechanisms and their coupling to the uptake machinery.
Fadok
V A
VA
Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA.
Henson
P M
PM
D018528:ATP-Binding Cassette Transporters / Q000235:genetics / Q000502:physiology; D000818:Animals; D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins; D017173:Caenorhabditis elegans / Q000166:cytology / Q000235:genetics / Q000502:physiology; D029742:Caenorhabditis elegans Proteins; D004331:Drosophila melanogaster / Q000166:cytology / Q000502:physiology; D015801:Helminth Proteins / Q000235:genetics / Q000502:physiology; D006801:Humans; D019476:Insect Proteins / Q000502:physiology; D008322:Mammals / Q000502:physiology; D008563:Membrane Lipids / Q000502:physiology; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology; D010587:Phagocytosis / Q000235:genetics / Q000502:physiology*; D010718:Phosphatidylserines / Q000502:physiology; D010750:Phosphoproteins / Q000235:genetics / Q000502:physiology; D013045:Species Specificity; D013499:Surface Properties
D018528:ATP-Binding Cassette Transporters; D051017:Apoptosis Regulatory Proteins; C111579:CED-5 protein, C elegans; C112888:CED-6 protein, C elegans; C112887:CED-7 protein, C elegans; D029742:Caenorhabditis elegans Proteins; D015801:Helminth Proteins; D019476:Insect Proteins; D008563:Membrane Lipids; D008565:Membrane Proteins; D010718:Phosphatidylserines; D010750:Phosphoproteins