[Pulse therapy with prospidin and methotrexate: comparative efficacy in rheumatoid arthritis (12-month controlled study)].
Efficiency of pulse-therapy with prospidin (500 mg for 5 days in hospital, 500-1000 mg for a month as maintenance) and methotrexate (30 mg a week i.v. in hospital, 7-10 mg a week as maintenance) was investigated in 93 patients with severe RA. The response to prospidin and methotrexate arose quickly (within 10-14 and 4-5 weeks, respectively) and occurred in 73 and 70% of patients, respectively. Withdrawal of the drug was caused by side effects of methotrexate (19.3%) and resistance to prospidin (23.2%).
Nemtsov
B F
BF
Benenson
E V
EV
Timina
O V
OV
D000328:Adult; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use*; D008875:Middle Aged; D011447:Prospidium / Q000627:therapeutic use*; D016896:Treatment Outcome
D018501:Antirheumatic Agents; D011447:Prospidium; D008727:Methotrexate
Sravnitel'naia éffektivnost' pul's-terapii prospidinom i metotreksatom pri revmatoidnom artrite (12-mesiachnoe kontroliruemoe issledovanie).