[A case of post-partum remission of acquired dyserythropoiesis, a rare cause of anemia in disseminated lupus erythematosus].
BACKGROUND
Amongst the various causes of anemia in systemic lupus erythematosus, isolated and acquired erythrocyte dysplasia is rare and most often part of global dysmyelopoiesis.


METHODS
The authors report a case of acquired erythrocyte dysplastic syndrome that occurred in a 34-year-old woman in whom previous diagnosis had evidenced systemic lupus erythematosus of rather benign course. Other causes of dysmyelopoiesis were ruled out. Myeloid stem cell cultures showed selective inhibition of erythroid cells growing, with no particular effect of the patient's serum. While a corticosteroid treatment with prednisone (1 mg/kg/d) did not show any efficacy upon anemia, the patient's pregnancy was followed by prolonged correction of hemoglobin, making possible the tapering of prednisone down to 10 mg/d.


CONCLUSIONS
Acquired erythrocyte dysplastic syndrome remains a rare cause of anemia in systemic lupus erythematosus. This case report suggests an immunological phenomenon, but the mechanisms underlying both the appearance and long-lasting remission after pregnancy remain unexplained.
Service de rhumatologie, hôpital Bichat-Claude-Bernard, Paris, France.
A
A
Kettaneh
G
G
Hayem
E
E
Palazzo
M
M
Debandt
J L
JL
Lebail-Darné
S
S
Roux
M F
MF
Kahn
O
O
Meyer
D000328:Adult; D000740:Anemia / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002478:Cells, Cultured; D015672:Erythroid Precursor Cells / Q000473:pathology; D004920:Erythropoiesis / Q000187:drug effects / Q000502:physiology; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000503:physiopathology; D049590:Postpartum Period; D011241:Prednisone / Q000627:therapeutic use; D011247:Pregnancy; D012075:Remission, Spontaneous
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D006454:Hemoglobins; D011241:Prednisone
Une observation de rémission post-partum d'une dysérythropoïèse acquise, une cause rare d'anémie au cours du lupus érythémateux disséminé.