Localized peeling skin syndrome: case report with ultrastructural study.
We report a young woman in whom the history, clinical features, histopathological and ultrastructural findings led to a diagnosis of peeling skin syndrome (PSS). PSS is a rare and not well classified genodermatosis, mainly characterized by the spontaneous separation of the stratum corneum from the stratum granulosum. The unusual feature in our patient was the strict localization to the palm. PSS has been described as a more generalized disease frequently sparing palms and soles. We propose the diagnosis label of 'localized PSS' for this previously undescribed variant of a rare keratinization defect.
Centre for Inherited Cutaneous Diseases, Institute for Dermatological Sciences, IRCCS, Ospedale Maggiore, University of Milan, Via Pace 9, 20122 Milan, Italy.
A
A
Brusasco
S
S
Veraldi
G
G
Tadini
R
R
Caputo
D000328:Adult; D004890:Erythema / Q000473:pathology; D005260:Female; D006229:Hand Dermatoses / Q000473:pathology*; D006801:Humans; D007642:Keratosis / Q000473:pathology*; D012867:Skin / Q000648:ultrastructure*; D013577:Syndrome