Synthesis of some new biologically active thiadiazolotriazinones.
4-Amino-6-arylmethyl-3-mercapto-1,2,4-triazin-5(4H)-ones 1 are condensed with aromatic carboxylic acids, aryloxyacetic acids and anilinoacetic acids 2 to yield 7-substituted-3-arylmethyl-4H-1,3,4-thiadiazolo[2,3-c]-1,2,4-tr iazin-4-ones 3. Phosphorus oxychloride is used as cyclizing agent. Some of the newly synthesized compounds are screened for their antibacterial activities.
Holla
B S
BS
Department of Post-Graduate Studies and Research in Chemistry, Mangalore University, India.
Sarojini
B K
BK
Gonsalves
R
R
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001407:Bacillus / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013057:Spectrum Analysis; D013211:Staphylococcus aureus / Q000187:drug effects; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D013830:Thiadiazoles