Congenital syphilis after treatment of maternal syphilis with a penicillin regimen exceeding CDC guidelines.
BACKGROUND
Although congenital syphilis usually occurs as a result of a failure to detect and treat syphilis in pregnant women, failures of the currently recommended regimen to prevent congenital syphilis have been reported.


METHODS
This report describes an infant with congenital syphilis despite maternal treatment with a regimen exceeding current CDC guidelines.


CONCLUSIONS
Regardless of the regimen used to treat syphilis during pregnancy, clinicians should recognize the possibility of occasional treatment failures and the importance of adequate follow-up of infants at risk for congenital syphilis.
Illinois Department of Public Health, Division of Infectious Diseases, Chicago, USA. cconover@idph.state.il.us
C S
CS
Conover
C A
CA
Rend
G B
GB
Miller
G P
GP
Schmid
D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002487:Centers for Disease Control and Prevention, U.S.; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D010406:Penicillins / Q000008:administration & dosage*; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D013590:Syphilis, Congenital / Q000175:diagnosis* / Q000209:etiology*; D013592:Syphilis, Latent / Q000150:complications / Q000188:drug therapy*; D017211:Treatment Failure; D014481:United States
D000900:Anti-Bacterial Agents; D010406:Penicillins