[Initial antiretroviral prescriptions in patients with HIV. Second semester 1994-second semester 1996].
OBJECTIVE
The nature of antiretroviral therapy has radically changed these last years. A study has been conducted on data obtained from the DMI2 information system to evaluate changes on treatments, immunity and transmission profile of the patient naive to antiretroviral therapy when initiating a therapy.


METHODS
DMI2 is a national, multicentered database which contains medical, epidemiological and economic information on hospital care for HIV patients. This study, on 18,510 patients followed up in one of the fifty hospitals belonging to the Centers for Information and Care of Human immune Deficiency, was conducted from the second half of 1994 to the second half of 1996.


RESULTS
The therapeutic changes seen on the whole seropositive population are also observed on these patients: the proportion of regimen with only one nucleoside analogue have decreased from 90.2% in 1994 to 7.5% in 1996. The proportion of treatment with two nucleoside analogues increased from 7.9% to 67.6%. The proportion of two nucleoside analogues with one protease inhibitor regimen increased from 1.9% in 1994 to 24.6% at the end of 1996. A study focused on the second semester of 1996 shows that the proportion of homo-bisexual patients initiating an antiretroviral treatment with a three antiretroviral agents combination (29.7%) is greater than the one in the IVDU group (20.4%) or in the heterosexual group (20.8%).


CONCLUSIONS
These results show that a higher number of patient naive to the antiretroviral therapy initiate therapy earlier, with a two or three agents combination preferentially and at a better stage of immunity.
Courtial-Destembert
S
S
Ministère de la santé, Direction des Hôpitaux, Paris.
Nadal
J M
JM
Bourdillon
F
F
Cavaignac
L
L
Tchakamian
S
S
D019380:Anti-HIV Agents / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D016208:Databases, Factual; D004346:Drug Information Services; D011307:Drug Prescriptions / Q000706:statistics & numerical data*; D004359:Drug Therapy, Combination; D004363:Drug Utilization / Q000706:statistics & numerical data / Q000639:trends; D005260:Female; D005500:Follow-Up Studies; D005602:France; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000635:transmission; D006801:Humans; D008297:Male; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data* / Q000639:trends*
D019380:Anti-HIV Agents
Les primoprescriptions d'antirétroviraux chez les patients atteints par le VIH. Second semestre 1994-second semestre 1996.