Synthesis and antimicrobial activity of coumarin 7-substituted cephalosporins and sulfones.
Some coumarin 7-substituted cephalosporins and related sulfones were prepared and an antimicrobial assay was performed. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) carried out on cephalosporins showed a potential activity of some of the synthesized compounds against Gram-positive microorganisms. The tests performed on the corresponding sulfones showed no significant activity, neither as antimicrobial agents nor as inhibitors of beta-lactamase. An association of sulfone 6a with ampicillin was observed to inhibit Gram-positive microorganisms with a lower MIC than for ampicillin alone.
Dipartimento Farmaco Chimico Tecnologico, Università di Cagliari, Italy.
L
L
Bonsignore
F
F
Cottiglia
H
H
Elkhaili
F
F
Jehl
S M
SM
Lavagna
G
G
Loy
F
F
Manna
H
H
Monteil
D
D
Pompei
D
D
Secci
D002511:Cephalosporins / Q000138:chemical synthesis* / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013450:Sulfones / Q000138:chemical synthesis* / Q000494:pharmacology
D002511:Cephalosporins; D013450:Sulfones