Cariostatic effects of a xylitol/NaF dentifrice in vivo.
Xylitol has been shown to reduce plaque acids, but its topical cariostatic effect has been equivocal. The purpose of the studies reported here was to optimise the xylitol/NaF combination in dentifrices for an improved anticaries activity. In the first study, the combination of 10 per cent xylitol with 1100 ppm F (NaF), 1100 ppm F (NaF), and placebo dentifrices were tested in a rat caries model to assess the cariostatic effect. The combination was significantly more effective than fluoride by itself (P = 0.05). The xylitol/NaF combination provided significantly more remineralisation of dentine than fluoride by itself. Collectively, results of these investigations confirm the improved anticaries effectiveness of the xylitol/NaF combination in a variety of animal and intra-oral models. A three-year clinical study confirmed these findings.
Colgate Palmolive Technology Center, New Jersey, USA.
A
A
Gaffar
J C
JC
Blake-Haskins
R
R
Sullivan
A
A
Simone
R
R
Schmidt
F
F
Saunders
D000143:Acids / Q000378:metabolism; D000328:Adult; D000368:Aged; D000818:Animals; D002327:Cariostatic Agents / Q000378:metabolism / Q000627:therapeutic use*; D018592:Cross-Over Studies; D003731:Dental Caries / Q000517:prevention & control*; D003743:Dental Enamel / Q000187:drug effects; D003773:Dental Plaque / Q000378:metabolism / Q000517:prevention & control; D003802:Dentifrices / Q000627:therapeutic use*; D003804:Dentin / Q000187:drug effects; D004195:Disease Models, Animal; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D010919:Placebos; D051381:Rats; D011919:Rats, Inbred Strains; D012463:Saliva / Q000378:metabolism; D012969:Sodium Fluoride / Q000378:metabolism / Q000627:therapeutic use*; D014089:Tooth Remineralization; D014993:Xylitol / Q000378:metabolism / Q000627:therapeutic use*
D000143:Acids; D002327:Cariostatic Agents; D003802:Dentifrices; D010919:Placebos; D012969:Sodium Fluoride; D014993:Xylitol