Overexpression of p53 in different subtypes of intestinal metaplasia and gastric cancer.
p53 immunostaining was evaluated in cancerous epithelia and adjacent intestinal metaplasia of 135 gastric cancer specimens. The differential p53 overexpression in different subtypes of intestinal metaplasia and gastric cancer suggests that type III intestinal metaplasia is the commonest lesion in dysplasia-carcinoma transition, particularly in the intestinal type of gastric cancer.
Department of Internal Medicine, National Taiwan University Hospital, Taipei.
M S
MS
Wu
C T
CT
Shun
W C
WC
Lee
C J
CJ
Chen
H P
HP
Wang
W J
WJ
Lee
J C
JC
Sheu
J T
JT
Lin
D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000473:pathology*; D008679:Metaplasia / Q000378:metabolism; D011230:Precancerous Conditions / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D016159:Tumor Suppressor Protein p53