[Increasing threshold of the epileptiform activity in the CA1 field of hippocampal slices of Krushinskiĭ-Molodkina rats as protective adaptation mechanism].
The Krushinsky-Molodkina rat CA1 hippocampal slices revealed an increased threshold of the epileptiform activity development, a depressed signal transmission in the presynaptic glutamatergic fibres, no long-term increase in excitability of the CA1 pyramidal neurons characteristic of Wistar rats following Mg2+ removal and K+ increase. These events suggest a protective adaptive mechanism preventing propagation of seizure activity into limbic structures of the rats.
Sem'ianov
A V
AV
Institute of Theoretical and Experimental Biophysics of the Russian Acad. Sci., Pushchino, Russia.
Morenkov
E D
ED
Kalemenev
S V
SV
Iaroshenko
V P
VP
Godukhin
O V
OV
D000161:Acoustic Stimulation; D000222:Adaptation, Physiological; D000818:Animals; D004827:Epilepsy / Q000235:genetics / Q000503:physiopathology*; D005110:Extracellular Space / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism / Q000503:physiopathology*; D007696:Kindling, Neurologic; D008274:Magnesium / Q000378:metabolism; D008297:Male; D011188:Potassium / Q000378:metabolism; D051381:Rats; D012640:Seizures / Q000235:genetics / Q000503:physiopathology
D008274:Magnesium; D011188:Potassium
Povyshenie poroga razvitiia épileptiformnoĭ aktivnosti v pole srezov gippokampa krys linii Krushinskogo-Molodkinoĭ kak adaptivnyĭ zashchi tnyĭ mekhanizm.