Physiology and healing dynamics of chronic cutaneous wounds.
In the last few decades, a great deal of progress has been made in understanding the cellular and biochemical interplay that comprises the normal wound healing response. This response is a complex process involving intricate interactions among a variety of different cell types, structural proteins, growth factors, and proteinases. The normal wound repair process consists of three phases--inflammation, proliferation, and remodeling--that occur in a predictable sequence and comprise a series of cellular and biochemical events. A review of the biochemical and physiologic processes that regulate wound healing and the cascade of cellular events that gives rise to the healing process is presented here.
Division of Plastic and Reconstructive Surgery, University of Louisville, Kentucky 40292, USA.
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D002908:Chronic Disease; D003094:Collagen / Q000096:biosynthesis; D017719:Diabetic Foot / Q000503:physiopathology*; D005347:Fibroblasts / Q000502:physiology; D006133:Growth Substances / Q000494:pharmacology; D006801:Humans; D007249:Inflammation; D012867:Skin / Q000293:injuries; D014945:Wound Healing / Q000502:physiology*
D006133:Growth Substances; D003094:Collagen