Quinolinic acid and sigma receptor ligand: effect on pyramidal neurons of the CA1 sector of dorsal hippocampus following peripheral administration in rats.
Male Wistar rats, weighing 200-220 g, were used in the study. Quinolinic acid and racemic pentazocine were administered alone or together. Quinolinic acid was administered intraperitoneally (i.p.) in a dose of 60 mmol, racemic pentazocine intramuscularly in a dose of 2 mg/kg, once every 24 h for 8 days. The control group received 1 ml of saline i.p. once daily for 8 days. Pentazocine alone produced no signs of alteration in the hippocampal formation. Quinolinic acid produced neurotoxic effect in the CA1 area of the hippocampal formation. The presence of the dark-degenerated pyramidal cells was a common sign of a delayed excitotoxic effect. Pentazocine added to quinolinic acid markedly attenuated the neurotoxic effect of quinolinic acid. In such cases, only single dark degenerated cells were seen.
Beskid
M
M
Laboratory of Histochemistry, Medical Centre of Postgraduate Education, Warszawa.
Rózycka
Z
Z
Taraszewska
A
A
D000701:Analgesics, Opioid / Q000493:pharmacokinetics*; D000818:Animals; D015220:Calcium Channels / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism*; D008024:Ligands; D008297:Male; D016202:N-Methylaspartate / Q000378:metabolism; D010423:Pentazocine / Q000493:pharmacokinetics*; D017966:Pyramidal Cells / Q000378:metabolism*; D017378:Quinolinic Acid / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D017480:Receptors, sigma / Q000378:metabolism*
D000701:Analgesics, Opioid; D015220:Calcium Channels; D008024:Ligands; D017480:Receptors, sigma; D016202:N-Methylaspartate; D017378:Quinolinic Acid; D010423:Pentazocine