Expression of immediate early gene c-fos in rat brain following increased intracranial pressure.
No attention has been given to an influence of the intracranial pressure (ICP) elevation on the brain at the level of the gene. In the present study, we originally attempted to evaluate the molecular biological changes of the brain, especially the expression of c-fos mRNA as a marker of cellular response, caused by increased ICP. Our results confirm that the neurons and non-neuronal cells are well able to tolerate the stress of increased ICP at the level of the gene, under the condition that cerebral blood flow (CBF) is maintained. A severe increase in ICP, which reduces CBF, enhances the c-fos mRNA expression in a similar fashion as in a forebrain ischemia model, except in the choroid plexus.
Department of Neurosurgery, Nagoya City University Medical School, Japan.
T
T
Matsumoto
A
A
Masago
K
K
Yamada
A
A
Iwata
S
S
Harada
M
M
Mase
D000818:Animals; D015870:Gene Expression / Q000502:physiology; D017781:Genes, Immediate-Early / Q000235:genetics*; D019586:Intracranial Hypertension / Q000235:genetics*; D007427:Intracranial Pressure / Q000235:genetics; D008297:Male; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar
D016760:Proto-Oncogene Proteins c-fos; D012333:RNA, Messenger