Does chronic hypoxia increase rat carotid body nitric oxide?
The carotid body plays an important role in ventilatory adaptation during chronic hypoxia. Nitric oxide (NO) may act as a regulator in neurotransmission, influencing the carotid body chemosensory discharge. The aim of the study was to understand if NO could contribute to the adaptation process during chronic hypoxia. The rats were kept in chronic hypoxia (10-11% inspired oxygen) for 12 days, while the controls were kept in room air (21% O2). The distribution for diaphorase activity and immunohistochemistry for nitric oxide synthase (NOS) showed that chronic hypoxia induces an increase in NOS activity in the carotid body. It was concluded that NO release increased during chronic hypoxia and causes an inhibitory effect on carotid chemosensory discharge of the rat carotid body.
Dipartimento di Scienze Biomediche, Facoltà di Medicina e Chirurgia, Università degli Studi G. d'Annunzio, Chieti, Italy. digiulio@unich.it
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Di Giulio
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Grilli
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De Lutiis
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Di Natale
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Sabatino
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Felaco
D000222:Adaptation, Physiological; D000818:Animals; D002344:Carotid Body / Q000201:enzymology / Q000378:metabolism* / Q000503:physiopathology; D004789:Enzyme Activation; D000860:Hypoxia / Q000378:metabolism* / Q000503:physiopathology; D007150:Immunohistochemistry; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism* / Q000502:physiology; D019001:Nitric Oxide Synthase / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D009569:Nitric Oxide; D019001:Nitric Oxide Synthase