The pathogenesis of HLA-B27 arthritis: role of HLA-B27 in bacterial defense.
The way in which a host accommodates invasive facultative intracellular bacteria must be the key to the development of reactive arthritis. Investigators have analyzed the bacterial events at several levels: invasion into host cells, intracellular survival, translocation from the sites of infection to the joints, residence in the joints, and evasion of host defense. Because HLA-B27 is present in higher incidence in patients with reactive arthritis and is an essential gene in the related ankylosing spondylitis, the role of HLA-B27 in host defense is also assumed to be important in the development of reactive arthritis. This review summarizes the various studies in this field.
Ikeda
M
M
Rheumatology Division, UCLA School of Medicine, Los Angeles, California, USA.
Yu
D T
DT
D001170:Arthritis, Infectious / Q000235:genetics / Q000276:immunology*; D016918:Arthritis, Reactive / Q000235:genetics / Q000276:immunology*; D001419:Bacteria / Q000472:pathogenicity; D001424:Bacterial Infections / Q000235:genetics / Q000276:immunology*; D018407:Bacterial Physiological Phenomena; D015796:HLA-B27 Antigen / Q000235:genetics / Q000276:immunology*; D006801:Humans; D013167:Spondylitis, Ankylosing / Q000235:genetics / Q000276:immunology*
D015796:HLA-B27 Antigen