[Anterior uveitis in HIV-infected patients. 3 cases in patients treated with an antiprotease].
OBJECTIVE
Uveitis is an ocular manifestation rarely observed in HIV-infected patients. We observed three cases of anterior uveitis without progressive retinitis in HIV patients receiving antiprotease treatment.


METHODS
The first patient developed a first episode of uveitis during ritonavir therapy. Two other episodes occurred with indinavir. The second patient developed uveitis when treated with indinavir. In the third patient, the first episode developed with indinavir and a second with a ritonavir-saquinavir combination. Uveitis was unilateral in 4 episodes. Clinical manifestations were red irritable eyes and, in 2 episodes, reduced visual acuity. The antiprotease was interrupted in 4 of the 6 episodes and clinical course was rapidly favorable.


CONCLUSIONS
Pure anterior uveitis should suggest drug induction in HIV infected patients; rifabutin is often the cause. Infectious causes predominate in case of total uveitis associating choroid and retinal involvement. Cytomegalovirus, herpes zoster, syphilis, and toxoplasmosis have been incriminated. Antiproteases would appear to be a new cause of anterior uveitis in HIV-infected patients.
Clinique de Maladies Infectieuses et tropicales, Hôpital Saint Louis, Paris.
S
S
Fournier
S
S
Deplus
M
M
Janier
Y
Y
Poinsignon
J M
JM
Decazes
J
J
Modai
D017088:AIDS-Related Opportunistic Infections / Q000821:virology; D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects*; D004338:Drug Combinations; D015658:HIV Infections / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000009:adverse effects*; D006801:Humans; D019469:Indinavir / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D017828:Rifabutin / Q000009:adverse effects; D019438:Ritonavir / Q000009:adverse effects; D019258:Saquinavir / Q000009:adverse effects; D014605:Uveitis / Q000821:virology; D014606:Uveitis, Anterior / Q000139:chemically induced*; D014792:Visual Acuity / Q000187:drug effects
D019380:Anti-HIV Agents; D004338:Drug Combinations; D017320:HIV Protease Inhibitors; D017828:Rifabutin; D019469:Indinavir; D019258:Saquinavir; D019438:Ritonavir
Uvéite antérieure chez des patients infectés par le VIH. 3 cas chez des patients traités par une antiprotéase.