Kinase-phosphatase competition regulates Bacillus subtilis development.
The major regulator of sporulation initiation in Bacillus subtilis is the phosphorelay, a multicomponent signal transduction system. A myriad of signals, both positive and negative, from the environment, cell cycle and metabolism is received and interpreted by the phosphorelay and integrated through the opposing activity of protein kinases and protein aspartate phosphatases to create an extremely sophisticated regulatory network.
Dept of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037, USA. mperego@scripps.edu
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D001412:Bacillus subtilis / Q000201:enzymology / Q000254:growth & development / Q000502:physiology*; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D011494:Protein Kinases / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D013170:Spores; D015533:Transcriptional Activation
D011494:Protein Kinases; D010744:Phosphoric Monoester Hydrolases