[Glutamine and the liver cell: metabolism, properties and the concept of metabolic regulation by cell swelling].
Glutamine is transported into the hepatocyte in a sodium-dependent manner. A consequence of the sodium-dependent entry of glutamine is an osmotic swelling of the cell. In the past, glutamine has been given a number of anabolic properties such as the stimulation of both glycogen and lipid synthesis from glucose. The mechanism through which glutamine activates key enzymes in these metabolic pathways involves the glutamine-induced cell swelling. Moreover, glutamine regulates gene expression of the beta-actin gene at a transcriptional level as well as that of the phosphoenolpyruvate carboxykinase gene by stabilizing its mRNA. Regulation of gene expression by glutamine also involves the cell swelling phenomena. Cell swelling is now regarded as a novel regulatory element of hepatic metabolism.
Groupe de biochimie et physiopathologie digestive et nutritionnelle, IFRMP n(o) 23 UFR Médecine-Pharmacie, Rouen.
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Lavoinne
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Husson
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Quillard
D000199:Actins / Q000235:genetics; D000818:Animals; D048429:Cell Size / Q000502:physiology; D005786:Gene Expression Regulation; D005973:Glutamine / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D050356:Lipid Metabolism; D008099:Liver / Q000166:cytology* / Q000378:metabolism*; D008112:Liver Glycogen / Q000378:metabolism; D009994:Osmolar Concentration; D019764:Phosphoenolpyruvate Carboxykinase (ATP) / Q000235:genetics; D012964:Sodium / Q000378:metabolism
D000199:Actins; D008112:Liver Glycogen; D005973:Glutamine; D012964:Sodium; D019764:Phosphoenolpyruvate Carboxykinase (ATP)
Glutamine et cellule hépatique: métabolisme, propriétés et concept de régulation du métabolisme par le gonflement cellulaire.