Radioiodine treatment and oxidative stress in thyroidectomised patients for differentiated thyroid cancers.
Post-operative radioiodine treatment of differentiated thyroid cancer occupies a well determined place in the treatment policy of this disease. Since little is known about erythrocytes oxidant and antioxidant status in patients with thyroid cancers after radioiodine treatment, we measured erythrocyte malondialdehyde (MDA) levels, as a marker of lipid peroxidation, erythrocyte reduced glutathione (GSH) levels and activities of GSH-Peroxidase and GSH-Reductase as antioxidants. We found that erythrocyte MDA levels were significantly higher, and erythrocyte GSH levels and activities of GSH-related enzymes were significantly lower in thyroidectomised patients after surgery than in healthy controls. Additionally, according to their thyroid hormone levels the patients had hypothyroidism at this time. In patients 2 days after radioiodine treatment both MDA and GSH levels and GSH-related enzyme activities were significantly increased when compared to their own initial levels. In conclusion, we suggested that radioiodine could facilitate or induce significant oxidant/antioxidant changes in erythrocytes-indirectly as a result of the internal radiotherapy with radioiodine.
Department of Biochemistry, Cerrahpaşa Medical Faculty, Istanbul University, Istanbul, Turkey.
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Konukoğlu
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Hatemi
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Arikan
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M
Demir
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Akçay
D018263:Adenocarcinoma, Follicular / Q000097:blood / Q000532:radiotherapy / Q000601:surgery; D000328:Adult; D015415:Biomarkers / Q000097:blood; D002291:Carcinoma, Papillary / Q000097:blood / Q000532:radiotherapy / Q000601:surgery; D004906:Erythrocyte Count; D004912:Erythrocytes / Q000166:cytology / Q000378:metabolism; D005260:Female; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D013964:Thyroid Neoplasms / Q000097:blood / Q000532:radiotherapy* / Q000601:surgery*; D013965:Thyroidectomy; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D015415:Biomarkers; D006454:Hemoglobins; D007457:Iodine Radioisotopes; D014284:Triiodothyronine; D008315:Malondialdehyde; D013972:Thyrotropin; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005978:Glutathione; D013974:Thyroxine