[Laboratory diagnosis of monoclonal gammopathies. Prospective study of 14 cases in Dakar, Senegal].
Monoclonal gammapathies are detected because of clinical symptoms and biological tests confirm their presence. Wishing to investigate these diseases, we carried out a series of biochemical tests on 14 patients from October 1995 to July 1996: protein, cryoglobulin, electrophoresis of proteins, proteinuria of BENCE JONES, C-reactive protein, weight measuring of immunoglobulins (Ig), immunofixation of Ig, creatinine and calcium. The results we obtained confirmed the presence of 14 cases of myeloma with: -9 IgG myelomas with 6 kappa light chains and 3 lambda light chains -4 IgA myelomas with 2 kappa light chains and 2 lambda light chains -1 IgG kappa, Ig lambda biclonal gammapathy united to a cryoglobulin of class I. We observed a predominance of the IgG over the others Ig and the kappa over the alpha light chains. The proteinuria of BENCE JONES was present among 3 patients, hypercalcemia among 4 patients and hypercreatininemia in 1 patient with chronic renal failure.
Faculté de pharmacie, Université C. A. Diop de Dakar, Sénégal.
P A
PA
Diop
D
D
Haudrechy
M
M
Sylla-Niang
A
A
Diedhiou
L
L
Ngom
P
P
Lopez-Sall
D001536:Bence Jones Protein / Q000652:urine; D001798:Blood Proteins / Q000032:analysis; D002118:Calcium / Q000097:blood; D003404:Creatinine / Q000097:blood; D003450:Cryoglobulins / Q000032:analysis; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007145:Immunoglobulin kappa-Chains / Q000097:blood; D007146:Immunoglobulin lambda-Chains / Q000097:blood; D008297:Male; D009101:Multiple Myeloma / Q000175:diagnosis; D010265:Paraproteinemias / Q000175:diagnosis*; D011446:Prospective Studies; D011507:Proteinuria / Q000652:urine; D012675:Senegal
D001798:Blood Proteins; D003450:Cryoglobulins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains; D001536:Bence Jones Protein; D003404:Creatinine; D002118:Calcium
Diagnostic au laboratoire des gammapathies monoclonales. Etude prospective de 14 cas à Dakar, Sénégal.