Infant growth and aorta total lipid fatty acids.
Abnormal fetal and infant growth have increasingly been correlated with adult onset cardiovascular disease. To date, there is little known about the lipid fatty acid profiles in infant cardiovascular tissue. Therefore, we analysed total lipid fatty acids from thoracic and abdominal aorta intima and media from 24 normally grown sudden infant death syndrome cases. Aorta from small for gestational age (n = 2), failure to thrive from birth (n = 3), and premature (n = 1) infants were also examined. Dihomo-gamma-linolenic acid (C20:3n-6) and oleic acid (C18:1n-9) concentrations were significantly lower in the thoracic than in the abdominal aorta. Similar dietary related differences were found in the subgroup (n = 15) of infants fed on formula milks. Both abdominal and thoracic intimal arachidonic (C20:4n-6) to dihomo-gamma-linolenic acid ratios were greater in the infants with retarded growth after birth than in their normally grown counterparts. Growth restriction in infancy might disrupt the normal accretion of vascular endothelial polyunsaturated fatty acids.
Department of Biochemistry, Royal Hospital for Sick Children, Yorkhill NHS Trust, Glasgow, Scotland, UK.
J
J
Farquharson
E C
EC
Jamieson
R W
RW
Logan
M B
MB
McFadyen
W J
WJ
Patrick
A G
AG
Howatson
F
F
Cockburn
D015126:8,11,14-Eicosatrienoic Acid / Q000032:analysis; D001012:Aorta, Abdominal; D001013:Aorta, Thoracic; D016718:Arachidonic Acid / Q000032:analysis; D001903:Bottle Feeding; D004730:Endothelium, Vascular / Q000737:chemistry*; D005183:Failure to Thrive / Q000378:metabolism; D005227:Fatty Acids / Q000032:analysis*; D006130:Growth Disorders / Q000378:metabolism*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000378:metabolism*; D007236:Infant, Small for Gestational Age / Q000378:metabolism*; D019301:Oleic Acid / Q000032:analysis; D018709:Statistics, Nonparametric; D013398:Sudden Infant Death
D005227:Fatty Acids; D016718:Arachidonic Acid; D019301:Oleic Acid; D015126:8,11,14-Eicosatrienoic Acid