Aculeoside B, a new bisdesmosidic spirostanol saponin from the underground parts of Ruscus aculeatus.
From the underground parts of Ruscus aculeatus, a new bisdesmosidic spirostanol saponin named aculeosides B (2) was isolated, and its structure was determined on the basis of spectroscopic analysis, including 2D NMR techniques. Aculeoside A (1), which was previously isolated from the same plant source, exhibited inhibitory activity on cell growth of leukemia HL-60 cells with an IC50 value of 0.48 microgram mL(-1), while aculeoside B (2) was inactive.
School of Pharmacy, Tokyo University of Pharmacy and Life Science, Horinouchi 1432-1, Hachioji, Tokyo 192-0392, Japan. mimakiy@ps.toyaku.ac.jp
Y
Y
Mimaki
M
M
Kuroda
A
A
Kameyama
A
A
Yokosuka
Y
Y
Sashida
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002240:Carbohydrate Sequence; D004144:Diosgenin / Q000031:analogs & derivatives*; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D019668:Liliaceae / Q000737:chemistry*; D008969:Molecular Sequence Data; D015394:Molecular Structure; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; C115560:aculeoside A; C115561:aculeoside B; D004144:Diosgenin