Epidermodysplasia verruciformis-like eruption complicating human immunodeficiency virus infection.
Three human immunodeficiency virus (HIV)-infected patients presented with disseminated pityriasis versicolor-like skin lesions. Histological examination showed features characteristic of epidermodysplasia verruciformis (EV). Hybridization studies demonstrated the presence of human papillomavirus (HPV) type 5 (HPV5) DNA in two patients and HPV20 in one. A relative increase in CD8+, CD57+ cells, which are known to inhibit cell-mediated cytolysis, was observed in all patients. HLA-DQB 0301 haplotype, which has been associated with EV, was detected in two patients. The findings suggest that infection with EV-associated HPV types can complicate HIV infection. Both cellular immune defects and a hitherto unknown genetic background might explain the occurrence of EV in HIV-infected patients.
Institut de Recherche sur la Peau, Hôpital Saint Louis, Paris, France.
C
C
Barzegar
C
C
Paul
P
P
Saiag
P
P
Cassenot
H
H
Bachelez
B
B
Autran
G
G
Gorochov
A
A
Petit
L
L
Dubertret
D017088:AIDS-Related Opportunistic Infections / Q000276:immunology / Q000473:pathology*; D000328:Adult; D004819:Epidermodysplasia Verruciformis / Q000276:immunology / Q000473:pathology*; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D008297:Male