[High-dose chemotherapy with autologous peripheral blood stem cell transfusion in the treatment of advanced testis cancer].
Four patients with advanced testis cancer were treated by high-dose chemotherapy supporting by autologous peripheral blood stem cell transplantation. High-dose chemotherapy (carboplatin 250 mg/m2 or nedaplatin 200 mg/m2, etoposide 1,500 mg/m2, ifosphamide 7.5 g/m2 was given and peripheral blood stem cell transfusion was performed 72 hours after the last dose of chemotherapy. High-dose chemotherapy. was given followed by 1 or 2 cycles of pre high-dose therapy consisting of cisplatin 100 mg/m2 or carboplatin 500 mg/m2, etoposide 450 mg/m2, ifosphamide 6 g/m2. All 4 patients were evaluable. Three patients obtained a complete response and one showed a partial response. The partial responder was given RPLND. The RPLND specimen showed necrotic tissue.
Dept. of Urology, Jikei Kashiwa Hospital.
Y
Y
Akasaka
J
J
Madarame
S
S
Yanada
H
H
Igarashi
A
A
Kuroda
J
J
Nakata
Y
Y
Ohishi
N
N
Kondou
M
M
Tomita
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D016190:Carboplatin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005047:Etoposide / Q000008:administration & dosage; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008297:Male; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D013736:Testicular Neoplasms / Q000628:therapy*; D014182:Transplantation, Autologous; D016896:Treatment Outcome
D009944:Organoplatinum Compounds; D005047:Etoposide; C053989:nedaplatin; D016190:Carboplatin; D002945:Cisplatin; D007069:Ifosfamide