[Disorder of the serotoninergic regulation of bone marrow cell proliferation under the action of a xenobiotic inducer of oxidative stress].
The work shows the results of experimental study of the characteristics of serotonin regulation of cell proliferation and programmed cell death in bone-marrow cells cultivated in diffusion chambers. It was found that the change in cell colony and cluster formation and death induced by this biogenic enzyme is disturbed by acrylamide, an inducer of oxidizing stress. Nicotinamide levels out the effect of acrylamide, which is evidence of the existence of NAD-dependent mechanisms in the serotonin-mediated regulation of hemopoiesis.
Egorova
A B
AB
Department of Pathophysiology, Krasnoyarsk State Medical University, Russia.
Uspenskaia
Iu A
IuA
Kruglik
O V
OV
Nefedova
V V
VV
Ivanov
V V
VV
Nefedov
V P
VP
D020106:Acrylamide / Q000494:pharmacology; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D015194:Diffusion Chambers, Culture; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D009536:Niacinamide / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects*; D011985:Receptors, Serotonin / Q000187:drug effects*; D012701:Serotonin / Q000494:pharmacology; D015262:Xenobiotics / Q000494:pharmacology*
D011985:Receptors, Serotonin; D015262:Xenobiotics; D020106:Acrylamide; D009536:Niacinamide; D012701:Serotonin
Narushenie serotoninergicheskoĭ reguliatsii proliferatsii kletok kostnogo mozga pri deĭstvii ksenobiotika-induktora okislitel'nogo stressa.