Helicobacter pylori cagA status and s and m alleles of vacA in isolates from individuals with a variety of H. pylori-associated gastric diseases.
The cagA gene was detected in 100% of 16 Helicobacter pylori isolates from patients with gastric carcinoma versus 78% of 18 isolates from patients with duodenal ulcers (P = 0.344) and only 64% of 22 isolates from patients with gastritis only (P = 0.005) in Brazil. Also, there was a significant association between isolation of cagA+ s1-type vacA H. pylori in cases of stomach cancer and ulcers as opposed to cases of gastritis only (P = 0.004), but this was not true in Houston (P = 0.238), where 94% of all isolates were cagA+.
Department of Medicine, Baylor College of Medicine, and Bacterial Enteropathogens Laboratory, Gastroenterology Section, Veterans Affairs Medical Center, Houston, Texas 77030, USA. devans@bcm.tmc.edu
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D000483:Alleles; D000942:Antigens, Bacterial; D001426:Bacterial Proteins / Q000235:genetics*; D001483:Base Sequence; D001938:Brazil / Q000453:epidemiology; D017931:DNA Primers / Q000235:genetics; D004381:Duodenal Ulcer / Q000150:complications / Q000382:microbiology*; D005756:Gastritis / Q000150:complications / Q000382:microbiology*; D005798:Genes, Bacterial; D016481:Helicobacter Infections / Q000150:complications / Q000453:epidemiology / Q000382:microbiology*; D016480:Helicobacter pylori / Q000235:genetics* / Q000302:isolation & purification*; D006801:Humans; D017720:Molecular Epidemiology; D016133:Polymerase Chain Reaction; D013274:Stomach Neoplasms / Q000150:complications / Q000382:microbiology*; D013781:Texas / Q000453:epidemiology
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D017931:DNA Primers; C074689:VacA protein, Helicobacter pylori; C080866:cagA protein, Helicobacter pylori