[Homocysteine, 5,10-methylenetetrahydrofolate reductase and deep venous thrombosis. Survey of 120 patients in internal medicine].
BACKGROUND
In the last few years, the association of deep vein thrombosis with frequent biological risk factors and genetic polymorphisms has significantly modified the field of venous thrombosis. In this study, we measured plasma homocysteine levels and tested the C677T methylenetetrahydrofolate reductase (MTHFR) mutation.


METHODS
Plasma homocysteine levels and test for C677T MTHFR mutation were performed in 120 consecutive patients with objectively diagnosed deep vein thrombosis, and in 120 controls.


RESULTS
We found a strong association between hyperhomocysteinemia and thrombosis (odd ratio: 2.43 IC 95% [1.27-4.7]). Conversely the C677T MTHFR gene polymorphism is only associated with hyperhomocysteinemia but not associated with thrombosis.


CONCLUSIONS
This is a preliminary study to the ongoing international multicentric study of SNFMI (Société nationale française de m0+edecine interne) concerning hyperhomocysteinemia and venous thrombosis.
Service de médecine interne B, hôpital Saint-Eloi, Montpellier, France.
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I
Quéré
J F
JF
Chassé
E
E
Dupuy
E
E
Bellet
P
P
Molho-Sabatier
G
G
Tobelem
C
C
Janbon
D000328:Adult; D000368:Aged; D000990:Antithrombin III / Q000032:analysis; D002852:Chromatography, Ion Exchange; D003627:Data Interpretation, Statistical; D005260:Female; D006579:Heterozygote; D006710:Homocysteine / Q000097:blood; D006720:Homozygote; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D008875:Middle Aged; D009154:Mutation; D016017:Odds Ratio; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000235:genetics*; D011110:Polymorphism, Genetic; D011486:Protein C / Q000032:analysis; D017293:Protein S / Q000032:analysis; D012307:Risk Factors; D015842:Serine Proteinase Inhibitors / Q000032:analysis; D011795:Surveys and Questionnaires; D020246:Venous Thrombosis / Q000097:blood / Q000209:etiology* / Q000235:genetics
D011486:Protein C; D017293:Protein S; D015842:Serine Proteinase Inhibitors; D006710:Homocysteine; D000990:Antithrombin III; D000587:Oxidoreductases Acting on CH-NH Group Donors; D042965:Methylenetetrahydrofolate Reductase (NADPH2)
Homocystéine, 5,10-méthylènetétrahydrofolate réductase et thrombose veineuse profonde. Enquête auprès de 120 patients en médecine interne.