Biologic activities of IL-1 and its role in human disease.
The role of the polypeptide proinflammatory cytokine IL-1 family represents a group of proteins that have contrasting and synergistic biologic responses. IL-1alpha and beta and their precursor forms are heavily involved in the enhancement of inflammation and host defense. Within this family of gene products, there is also a naturally occurring receptor antagonist, IL-1ra, as well as a family of receptor proteins that have differential signaling functions and activities. The study of these proteins in human disease, including allergic disease and type 1 hypersensitivity responses, has led to a better understanding of the underlying general inflammation associated with these syndromes and has provided opportunities to look at new forms of intervention in allergic disease and asthma.
Division of Allergy and Clinical Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, USA.
L J
LJ
Rosenwasser
D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D006969:Hypersensitivity, Immediate / Q000276:immunology*; D007375:Interleukin-1 / Q000276:immunology*; D011487:Protein Conformation; D013329:Structure-Activity Relationship
D007375:Interleukin-1