Wegener's granulomatosis: controversies and current concepts.
Wegener's granulomatosis, the most common of the pulmonary granulomatous vasculitides, may affect virtually any organ. Complications resulting from chronic cytotoxic therapy have led to novel treatment strategies. These alternative therapeutic modalities are promising, but additional studies are required to define their roles.
Lynch
J P
JP
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109-0360, USA.
Hoffman
G S
GS
D000293:Adolescent; D000328:Adult; D000890:Anti-Infective Agents / Q000009:adverse effects / Q000627:therapeutic use; D001379:Azathioprine / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D005493:Folic Acid Antagonists / Q000009:adverse effects / Q000627:therapeutic use; D014890:Granulomatosis with Polyangiitis / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D008727:Methotrexate / Q000009:adverse effects / Q000627:therapeutic use; D008875:Middle Aged; D010784:Photomicrography; D014057:Tomography, X-Ray Computed; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects / Q000627:therapeutic use
D000890:Anti-Infective Agents; D005493:Folic Acid Antagonists; D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D003520:Cyclophosphamide; D001379:Azathioprine; D008727:Methotrexate