[Value of antibody titers for diagnosis of neuroborreliosis].
Neuroborreliosis is a very frequent subtype of infection with Borrelia burgdorferi. Because of the widely spread inapparent infections finding of diagnosis by analysis of serum antibodies is very difficult. In the years 1990-1994 the serum of 6.775 patients of the Department of Neurology in Homburg, Germany was analysed with regard to Borrelia burgdorferi specific IgG antibodies. 24% showed a positive serum titer and 20% a borderline result. 73 patients showed a specific intrathecal IgG antibody synthesis. In contrast to patients with antibodies in serum these patients showed a significant cumulation during summer. The high percentage of positive serum titers and the season independence support the assumption of widely spread inapparent infections. If a patient shows neurological symptoms the finding of serum antibodies against Borrelia burgdorferi is not sufficient for the diagnosis of Neuroborreliosis. A specific intrathecal synthesis of antibodies, is the most reliable serological indicator for Neuroborreliosis. Intrathecal synthesis usually starts three to four weeks after the first clinical symptoms.
Woessner
R
R
Neurologische Klinik, Universitätskliniken des Saarlandes, Homburg/Saar.
Treib
J
J
Haass
A
A
Stoll
M
M
Holzer
G
G
Schimrigk
K
K
D000907:Antibodies, Bacterial / Q000134:cerebrospinal fluid*; D000918:Antibody Specificity / Q000276:immunology; D015748:Borrelia burgdorferi Group / Q000276:immunology*; D002494:Central Nervous System Infections / Q000175:diagnosis* / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid*; D008193:Lyme Disease / Q000175:diagnosis* / Q000276:immunology; D020019:Neurocysticercosis; D009460:Neurologic Examination; D012016:Reference Values; D012621:Seasons; D012680:Sensitivity and Specificity
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G
Wertigkeit von Antikörpertitern für die Diagnose einer Neuroborreliose.