[Pharmacology of the GABA receptor functions in the central nervous systems].
gamma-Aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the central nervous system. GABA receptors have been classified into at least two categories, GABA(A) receptors, which are heterogeneous multimeric ligand-gated Cl channels, and GABA(B) receptors, which are coupled to G-proteins. GABA(B) receptors have not only a physiological role in synaptic transmission, but also are important in pathological conditions associated with absence epilepsy, cognitive disorders and nociception. This review describes our current knowledge of the neuropharmacology and neurochemistry of GABA(B) receptors, including their heterogeneity as well as the therapeutic potential of the drugs which interact with these sites.
College of Pharmacy, Nihon University, Chiba, Japan.
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Fukuda
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Ito
D000818:Animals; D002490:Central Nervous System / Q000502:physiology*; D004195:Disease Models, Animal; D004832:Epilepsy, Absence / Q000188:drug therapy / Q000209:etiology; D018756:GABA Antagonists / Q000627:therapeutic use; D006801:Humans; D051379:Mice; D009943:Organophosphorus Compounds / Q000627:therapeutic use; D011963:Receptors, GABA-A / Q000502:physiology*; D018080:Receptors, GABA-B / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology; D014157:Transcription Factors / Q000378:metabolism
D018756:GABA Antagonists; D009943:Organophosphorus Compounds; D011963:Receptors, GABA-A; D018080:Receptors, GABA-B; D014157:Transcription Factors; C066430:CGP 35348