[The role of hyper-homocysteinemia in the etiology of some vascular diseases].
About 5% of population have a highly, while other 15% a moderately elevated plasma homocysteine level. Hyperhomocysteinemia may be responsible about 10-20% of coronary artery, 40% of cerebrovascular and 60% of peripheral vascular diseases. There in an inverse relationship between folate, cobalamin and pyridoxine intake or blood level and plasma homocysteine level. In addition, the intake of these three B vitamins can reduce high plasma homocysteine level. Folate-folic acid seems to be the most important in homocysteine reduction due to the compensation of thermolabile methylenetetrahydrofolate reductase insufficiency, however, a milder impact of cobalamin any pyridoxine (mainly following a methionine load test) is also proved. There are possibilities to reduce risk associated with elevated homocysteine: e. g. dietary supplementation or food fortification. In Hungary bread enriched by folic acid, cobalamin and pyriodixine might reduce rate of vascular diseases due to hyperhomocysteinemia.
Czeizel
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Nemzeti Egészségvédelmi Intézet, Budapest.
Matos
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D002561:Cerebrovascular Disorders / Q000097:blood* / Q000209:etiology / Q000517:prevention & control; D003327:Coronary Disease / Q000097:blood* / Q000209:etiology / Q000517:prevention & control; D004035:Diet Therapy; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D016491:Peripheral Vascular Diseases / Q000097:blood* / Q000209:etiology / Q000517:prevention & control; D012307:Risk Factors; D014803:Vitamin B Complex / Q000008:administration & dosage / Q000494:pharmacology
D006710:Homocysteine; D014803:Vitamin B Complex
Hyperhomocysteinaemia szerepe az egyes érrendszeri betegségek kóreredetében.