Synthesis and modeling studies of a potent conformationally rigid muscarinic agonist: 1-azabicyclo[2.2.1]heptanespirofuranone.
Department of Chemistry, Astra Arcus USA, P.O. Box 20890, Rochester, New York 14602, USA.
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Wu
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Kover
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Semus
D000818:Animals; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D000242:Cyclic AMP / Q000096:biosynthesis; D006168:Guinea Pigs; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D006868:Hydrolysis; D066298:In Vitro Techniques; D008958:Models, Molecular; D008968:Molecular Conformation; D018721:Muscarinic Agonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009206:Myocardium / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism; D051381:Rats; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
D019086:Bridged Bicyclo Compounds, Heterocyclic; D018721:Muscarinic Agonists; D010716:Phosphatidylinositols; D013141:Spiro Compounds; C115418:dihydro-4'-methylspiro(1-azabicyclo(2.2.1)heptane-3,5'(4'H)-furan)-3'-one; D000242:Cyclic AMP