Ofloxacin clearance during hemodialysis: a comparison of polysulfone and cellulose acetate hemodialyzers.
The pharmacokinetics of ofloxacin were studied in 13 patients with end-stage renal disease during hemodialysis using two different dialyzers: a polysulfone membrane (Fresenius F6) and a cellulose acetate dialyzer (Nissho Nipro FB-150T). All patients received 100 mg ofloxacin orally per day before dialysis. The hemodialysis clearance per square meter surface area was significantly different, with 5.0+/-0.7 L/h and 3.7+/-1.6 L/h, respectively. The serum concentration was reduced by a 3-hour hemodialysis by 49.6%+/-5.8% per square meter surface area and 45.5%+/-4.8% per square meter surface area. The half-life was 4.2+/-1.8 hours and 4.8+/-1.6 hours during the hemodialysis period and 22.8+/-2.2 hours and 23.3+/-1.7 hours between the dialysis sessions, respectively. Comparing polysulfone and cellulose acetate dialyzers, the material of the membrane influences the half-life, the dialysis clearance, and the percentage of drug extracted during hemodialysis. We conclude that the type of dialyzer used has to be taken into account in dosage recommendations for antimicrobial therapy in hemodialysis patients.
Department of Internal Medicine I, Vienna Medical School, Austria. florian.thalhammer@akh-wien.ac.at
F
F
Thalhammer
J
J
Kletzmayr
I
I
El Menyawi
J
J
Kovarik
A R
AR
Rosenkranz
F
F
Traunmüller
W H
WH
Hörl
H
H
Burgmann
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000097:blood / Q000493:pharmacokinetics*; D001672:Biocompatible Materials; D002482:Cellulose / Q000031:analogs & derivatives*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism* / Q000628:therapy; D008567:Membranes, Artificial; D008875:Middle Aged; D015242:Ofloxacin / Q000097:blood / Q000493:pharmacokinetics*; D011108:Polymers; D006435:Renal Dialysis / Q000295:instrumentation*; D013450:Sulfones
D000890:Anti-Infective Agents; D001672:Biocompatible Materials; D008567:Membranes, Artificial; D011108:Polymers; D013450:Sulfones; C017662:polysulfone P 1700; C005062:acetylcellulose; D002482:Cellulose; D015242:Ofloxacin