Isochromosomes 7q and 17q in Wilms tumor.
We report the cytogenetic findings in a Wilms tumor from a 4-year-old boy. Karyotypic analysis revealed isochromosomes of 7q and 17q as coexisting clonal aberrations. The finding is notable in view of recent reports of i(7q) as a nonrandom event in Wilms tumor and the emerging evidence for genetic heterogeneity in this tumor.
Sreekantaiah
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Department of Pathology, New York Medical College, Valhalla 10595, USA.
Beneck
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D002675:Child, Preschool; D002886:Chromosomes, Human, Pair 17; D002897:Chromosomes, Human, Pair 7; D006801:Humans; D018404:Isochromosomes; D007621:Karyotyping; D008297:Male; D009396:Wilms Tumor / Q000235:genetics*