Catecholamine-resistant cardiovascular collapse after propofol, atracurium and gentamicin.
A 43-year-old male received intravenous propofol, atracurium and gentamicin and experienced cardiovascular collapse with the features of an acute drug reaction. Prolonged cardiopulmonary resuscitation with fluids and large amounts of adrenaline and noradrenaline led to full recovery without neurological deficit. No biochemical abnormality was detected.
Department of Anaesthesia, Derriford Hospital, Plymouth, UK.
J R
JR
Sneyd
D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use*; D000328:Adult; D018686:Anesthetics, Intravenous / Q000009:adverse effects*; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001279:Atracurium / Q000009:adverse effects*; D016887:Cardiopulmonary Resuscitation; D004342:Drug Hypersensitivity / Q000209:etiology; D004837:Epinephrine / Q000627:therapeutic use*; D005440:Fluid Therapy; D005500:Follow-Up Studies; D005839:Gentamicins / Q000009:adverse effects*; D006801:Humans; D008297:Male; D003473:Neuromuscular Nondepolarizing Agents / Q000009:adverse effects*; D009638:Norepinephrine / Q000627:therapeutic use*; D015742:Propofol / Q000009:adverse effects*; D012769:Shock / Q000139:chemically induced*; D014662:Vasoconstrictor Agents / Q000627:therapeutic use*
D000316:Adrenergic alpha-Agonists; D018686:Anesthetics, Intravenous; D000900:Anti-Bacterial Agents; D005839:Gentamicins; D003473:Neuromuscular Nondepolarizing Agents; D014662:Vasoconstrictor Agents; D001279:Atracurium; D009638:Norepinephrine; D015742:Propofol; D004837:Epinephrine