Expanded genomic organization of conserved mammalian MHC class I-related genes, human MR1 and its murine ortholog.
MR1 is a major histocompatibility complex (MHC) class I-related gene located outside the human MHC. Among several divergent class I molecules, the predicted MR1 molecule is closest, in the alpha1 and alpha2 domains, to the class I group to which the vertebrate classical class I molecules belong. We report here the genomic organizations of the human MR1 and mouse Mr1 genes. Both genes exhibit genomic structures largely similar to those of the MHC class I genes. However, they are highly expanded in their scale in contrast to the classical MHC class I genes. Inclusion of transposable elements into introns seems to partly contribute to these genomic structures. Several other MHC class I-related genes also show relatively large genomic structures. The present study extended heterogeneity in the genomic organization among the class I gene family by revealing a highly expanded structure of the human MR1 gene and its murine ortholog.
Institute for Comprehensive Medical Science, Fujita Health University, Aichi, Toyoake, 470-11, Japan.
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Yamaguchi
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Kurosawa
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Hashimoto
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D017124:Conserved Sequence; D005805:Genes, MHC Class I; D016678:Genome; D015894:Genome, Human; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D007438:Introns / Q000235:genetics; D051379:Mice; D015778:Minor Histocompatibility Antigens; D008969:Molecular Sequence Data; D017421:Sequence Analysis
D015395:Histocompatibility Antigens Class I; C094840:MR1 protein, human; D015778:Minor Histocompatibility Antigens; C490628:Mr1 protein, mouse