[Biocompatibility of a porous alumina orbital implant. Preliminary results of an animal experiment].
OBJECTIVE
Evaluation of clinical tolerance and scanning electron microscopy study of the bio-colonisation of a porous ceramical alumina implant after evisceration of the rabbit. Preliminary results.


METHODS
Sixteen white New Zealand rabbits were eviscerated. A porous hydroxyde alumina ball was implanted in the opened sclera and explanted 15, 30, and 90 days after implantation. Clinical tolerance was assessed and implant tissular ingrowth was analyzed by scanning electron microscopy.


RESULTS
One infection was observed and there was no conjunctival breakdown. Fibrovascular ingrowth occurred as soon as 15 days after implantation, and was full at one month.


CONCLUSIONS
Porous alumina implant orbital tissue tolerance and fast fibrovascular ingrowth in the rabbit socket suggest promising result in the human anophthalmic socket.
Service d'Ophtalmologie, Hôtel-Dieu, Paris.
X
X
Morel
A
A
Rias
B
B
Briat
A
A
el Aouni
F
F
D'Hermies
J P
JP
Adenis
J M
JM
Legeais
G
G
Renard
D000537:Aluminum Oxide / Q000009:adverse effects / Q000737:chemistry; D000818:Animals; D004866:Equipment Contamination; D006801:Humans; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D020273:Orbital Implants / Q000009:adverse effects / Q000382:microbiology; D016062:Porosity; D016459:Prosthesis-Related Infections / Q000209:etiology; D011817:Rabbits; D013997:Time Factors
D000537:Aluminum Oxide
Biocompatibilité dans la cavité orbitaire d'une bille en alumine poreuse. Résultats préliminaires de l'expérimentation animale.