Identification of a novel multifunctional structural domain in the herpes simplex virus type 1 genome: implications for virus latency.
A domain, previously termed RE1, exists within the herpes simplex virus type 1 genome potentially influencing expression of immediate early genes and the latency associated transcripts. This domain consists of 10 tandem copies of a CT-rich sequence. We demonstrate that this domain binds multiple host-cell factors that may allow RE1 to act either as a transcriptional regulator and/or to affect nucleosomal and DNA structure in the latent genome.
Quinn
J P
JP
Department of Veterinary Pathology, University of Edinburgh, UK.
McGregor
R A
RA
Fiskerstrand
C E
CE
Davey
C
C
Allan
J
J
Dalziel
R G
RG
D000818:Animals; D004247:DNA / Q000378:metabolism; D016679:Genome, Viral; D006367:HeLa Cells; D018259:Herpesvirus 1, Human / Q000235:genetics*; D006801:Humans; D051381:Rats; D017208:Rats, Wistar; D017735:Virus Latency
D004247:DNA