[Sarcoidosis and pregnancy. A retrospective study of 11 cases].
OBJECTIVE
To analyze the evolutive profile of sarcoidosis together with reciprocal interactions between pregnancy and sarcoidosis.


METHODS
All events that occurred during pregnancy in 11 women presenting with sarcoidosis were analyzed. Histological confirmation was obtained for the 11 cases. For all pregnancies were analyzed the course of both sarcoidosis and pregnancy, and the influence of pregnancy on the disease evolution.


RESULTS
Among 33 pregnancies, 23 led to the birth of healthy fetuses (five spontaneous abortions, four voluntary abortions, and one therapeutic abortion). The major event was fetal hypotrophy in six cases. Three of them occurred during pregnancy in prednisone-treated patients with active sarcoidosis. No relapse of cured sarcoidosis or further evolution of sarcoidosis that was inactivated as of the beginning of pregnancy were observed. The course of active sarcoidosis varied, as improvement (one case), worsening (two cases) and stabilization (two cases) were observed. During the first year of follow-up after delivery, four relapses and, in two cases, preliminary signs of the disease were observed.


CONCLUSIONS
Apart from the hypothetical but not definite risk of hypotrophy, no negative interaction between sarcoidosis and pregnancy could be established. Pregnancy does not seem to interfere with the course of sarcoidosis. Considering the risk of relapse after delivery, pregnant women presenting with sarcoidosis should benefit from clinical and radiological follow-up.
Service de médecine interne, Hôpital de la Pitié-Salpêtrière, Paris, France.
C
C
Chapelon Abric
C
C
Ginsburg
V
V
Biousse
B
B
Wechsler
C
C
de Gennes
Y
Y
Darbois
J
J
Janse Marec
P
P
Godeau
J C
JC
Piette
D000028:Abortion, Induced; D000022:Abortion, Spontaneous / Q000209:etiology; D000032:Abortion, Therapeutic; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D018450:Disease Progression; D005260:Female; D005315:Fetal Diseases / Q000209:etiology; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D007743:Labor, Obstetric; D011241:Prednisone / Q000627:therapeutic use; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology*; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D012507:Sarcoidosis / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology*
D000893:Anti-Inflammatory Agents; D011241:Prednisone
Sarcoïdose et grossess. Etude retrospective de 11 cas.