The in vitro motility response to various anthelmintics of third-stage larvae of Oesophagostomum spp. from pigs.
The in vitro activities of thiabendazole, levamisole, pyrantel, morantel and ivermectin against Oesophagostomum spp., the nodular worm of pigs, were determined and compared. The study was carried out using isolates of O. dentatum and O. quadrispinulatum, which had been defined in vivo. Infective larvae were exposed to the anthelmintics for 24 h and then placed in a micromotility meter. All the treatments significantly reduced the motility of the ensheathed L3 larvae, but the micromotility meter was not able to differentiate between anthelmintic resistant and anthelmintic susceptible isolates.
Parasitological Institute, Slovak Academy of Sciences, Kosice, Slovak Republic.
M
M
Várady
J
J
Corba
G
G
Hrcková
D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D004351:Drug Resistance; D007559:Ivermectin / Q000494:pharmacology; D007814:Larva / Q000187:drug effects; D007978:Levamisole / Q000494:pharmacology; D009015:Morantel / Q000494:pharmacology; D009815:Oesophagostomum / Q000187:drug effects*; D011715:Pyrantel / Q000494:pharmacology; D013552:Swine / Q000469:parasitology; D013827:Thiabendazole / Q000494:pharmacology
D000871:Anthelmintics; D007978:Levamisole; D011715:Pyrantel; D007559:Ivermectin; D009015:Morantel; D013827:Thiabendazole