Extramedullary granulopoiesis mimicking recurrent lymphoma after prolonged administration of human recombinant granulocyte colony-stimulating factor.
Human recombinant granulocyte colony-stimulating factor (G-CSF) has become a treatment of choice for neutropenia of diverse etiologies. We describe a 71-year-old man who, while receiving G-CSF for graft failure after peripheral blood stem cell transplant, developed dramatic extramedullary granulopoiesis that mimicked recurrent lymphoma.
Friedman
H D
HD
Pathology and Laboratory Medicine, VA Healthcare Network Upstate NY at Syracuse, 13210-2796, USA.
Sanderson
S O
SO
Stein
C K
CK
Shrimpton
A
A
Gonchoroff
N J
NJ
Zamkoff
K W
KW
Loughran
T P
TP
D000368:Aged; D003937:Diagnosis, Differential; D016044:Fusion Proteins, bcr-abl / Q000032:analysis; D015322:Gene Rearrangement, B-Lymphocyte; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage*; D006098:Granulocytes / Q000166:cytology*; D006411:Hematopoiesis, Extramedullary; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D019891:Leukopoiesis; D008223:Lymphoma / Q000235:genetics; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis* / Q000503:physiopathology*; D008297:Male; D016133:Polymerase Chain Reaction; D011994:Recombinant Proteins / Q000008:administration & dosage
D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D016044:Fusion Proteins, bcr-abl