Fatty acid incorporation depicts brain activity in a rat model of Parkinson's disease.
Following pulse labeling with [3H]arachidonic acid ([3H]AA), its incorporation pattern in brain reflects regional changes in neurotransmitter signal transduction using phospholipase A2, that is, functional activity. In a rat model of Parkinson's disease, unilateral 6-hydroxydopamine lesion in the substantia nigra, [3H]AA acid incorporation from blood was increased in cerebral cortex, caudate putamen, globus pallidus, entopeduncular nucleus, subthalamic nucleus and substantia nigra pars reticulata ipsilateral to the lesion. This increased [3H]AA incorporation likely reflects disinhibition of basal ganglia and cortical circuits secondary to absent inhibitory nigrostriatal dopaminergic input.
Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892-1582, USA.
T
T
Hayakawa
M C
MC
Chang
J M
JM
Bell
R
R
Seeman
S I
SI
Rapoport
N M
NM
Appel
D000818:Animals; D001479:Basal Ganglia / Q000378:metabolism; D001921:Brain / Q000378:metabolism / Q000502:physiology*; D001931:Brain Mapping; D002421:Caudate Nucleus / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D004195:Disease Models, Animal; D005227:Fatty Acids / Q000378:metabolism*; D007839:Functional Laterality / Q000502:physiology; D005917:Globus Pallidus / Q000378:metabolism; D008297:Male; D010302:Parkinson Disease, Secondary / Q000378:metabolism / Q000503:physiopathology*; D010741:Phospholipases A / Q000378:metabolism; D054467:Phospholipases A2; D011699:Putamen / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction / Q000502:physiology*
D005227:Fatty Acids; D010741:Phospholipases A; D054467:Phospholipases A2