[The role of adenosine in the central nervous system].
Adenosine is one of the normal elements in body fluid including extracellular fluid within the CNS. Its normal level is 0.03-0.3 mumol/L. When ATP's metabolism loses balance, for example, during ischemia, the level of adenosine increases dramatically, may reach as much as 1000 times of the normal. Adenosine plays many physiological and pathological roles in CNS via its receptors. It is recognized as an inhibitory neuromodulator playing a neuroprotective role in CNS.
Zhang
W L
WL
Department of Neurobiology, Capital University of Medical Sciences, Beijing.
Lu
G W
GW
D000241:Adenosine / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000502:physiology*; D006801:Humans; D018377:Neurotransmitter Agents / Q000378:metabolism; D018047:Receptors, Purinergic P1 / Q000502:physiology
D018377:Neurotransmitter Agents; D018047:Receptors, Purinergic P1; D000241:Adenosine