Parasite immunology: pathways for expelling intestinal helminths.
Helminth parasites induce strong immune responses that are initiated by cytokines, in the first instance interleukin-4 and interleukin-13. Recent studies of knockout mice deficient in these mediators or their shared receptor have revealed discrete pathways required for expulsion of different gut parasites.
Maizels
R M
RM
Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh, EH10 5PB, Scotland, UK. r.maizels@ed.ac.uk
Holland
M J
MJ
D000818:Animals; D016207:Cytokines / Q000276:immunology*; D004804:Eosinophils / Q000276:immunology; D007411:Intestinal Diseases, Parasitic / Q000276:immunology*; D008407:Mast Cells / Q000276:immunology; D051379:Mice; D009348:Nematoda / Q000276:immunology*; D009349:Nematode Infections / Q000276:immunology*
D016207:Cytokines