Indium-111 satumomab pendetide: the first FDA-approved monoclonal antibody for tumor imaging.
Colon cancer is the second most common cause of cancer mortality. Ovarian cancer is the most common gynecologic malignancy cause of death in women. A labeled monoclonal antibody attaches to a tumor-associated antigen and allows these tumor masses to be imaged or treated, depending on the radionuclide used. Indium-111 satumomab pendetide was the first labeled monoclonal antibody to be approved by the Food and Drug Administration (FDA) for tumor imaging. It is reactive with most colorectal and ovarian cancers, as well as other cancers. After reading this article, the technologist will understand the FDA approval process, phase trial results, safety and adverse reactions, human antimurine antibody response, indications, imaging protocol, and strengths and weaknesses of imaging with satumomab pendetide. Representative cases are presented.
Nuclear Medicine Department, William Beaumont Hospital, Royal Oak, MI 48073-6769, USA.
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D000368:Aged; D000911:Antibodies, Monoclonal / Q000009:adverse effects / Q000737:chemistry; D002986:Clinical Trials as Topic; D003110:Colonic Neoplasms / Q000000981:diagnostic imaging*; D017277:Drug Approval; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009842:Oligopeptides / Q000009:adverse effects / Q000737:chemistry; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging*; D004369:Pentetic Acid / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000737:chemistry; D011237:Predictive Value of Tests; D016719:Radioimmunodetection / Q000379:methods; D019275:Radiopharmaceuticals / Q000009:adverse effects; D012449:Safety; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed; D014481:United States; D014486:United States Food and Drug Administration
D000911:Antibodies, Monoclonal; C063430:Indium 111In-satumomab pendetide; D007205:Indium Radioisotopes; D009842:Oligopeptides; D019275:Radiopharmaceuticals; D004369:Pentetic Acid