[Effect of (+/-)12-chloroscoulerine on brain dopamine receptors].
OBJECTIVE
To assess potencies of tetrahydroprotoberberines (THPB) and hydrobenzyltetrahydroisoquinolines (HBTI) on DA receptors.


METHODS
The receptor binding assay with calf striatum to D1 and D2 receptors, and the animal behavior tests were used.


RESULTS
(+/-) 12-Chloroscoulerine (CSL) was the most potent one among the THPB and HBTI. The affinities of CSL to D1 and D2 receptors were 13 and 51 nmol.L-1, respectively. In rats, CSL showed an antagonistic effect on the stereotypy and induced catalepsy. In the 6-OHDA lesioned rats, however, CSL exerted the agonistic effect to DA receptors.


CONCLUSIONS
CSL had dual actions to DA receptors and its effects were similar to that of (-)stepholidine.
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China.
L J
LJ
Chen
Y
Y
Xi
D W
DW
Pang
Q T
QT
Zhou
G Z
GZ
Jin
D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors; D001600:Berberine Alkaloids / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism*; D002375:Catalepsy / Q000139:chemically induced; D002417:Cattle; D018492:Dopamine Antagonists; D008297:Male; D011869:Radioligand Assay; D051381:Rats; D017207:Rats, Sprague-Dawley; D011954:Receptors, Dopamine / Q000187:drug effects*; D013239:Stereotyped Behavior
C099468:12-chloroscoulerine; D001600:Berberine Alkaloids; D018492:Dopamine Antagonists; D011954:Receptors, Dopamine; D001058:Apomorphine