[Dependence of cardiovascular effects of adenosine on the blood circulation type in rats].
Administration of adenosine increased the RR interval in greater degree at hyper- than in hypodynamic blood circulation type. The AV-blockade and atrial flutter were maximal in rats with hyperdynamic type of blood circulation. Propranolol weakened the adenosine cardiotropic effect whereas cholinoblockators enhanced it. Neurohumoral regulation exerted no effect on the adenosine hypotensive action.
Institute of Experimental Medicine of the Russian Acad. Med. Sci., St. Petersburg, Russia.
I B
IB
Krylova
V V
VV
Eliseev
N S
NS
Sapronov
N R
NR
Evdokimova
V I
VI
Ovsiannikov
D000241:Adenosine / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001281:Atrial Fibrillation / Q000139:chemically induced / Q000503:physiopathology; D001775:Blood Circulation / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002317:Cardiovascular Agents / Q000494:pharmacology* / Q000633:toxicity; D004569:Electroencephalography; D006327:Heart Block / Q000139:chemically induced / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D008297:Male; D051381:Rats
D000959:Antihypertensive Agents; D002317:Cardiovascular Agents; D000241:Adenosine
Zavisimost' kardiovaskuliarnykh éffektov adenozina ot tipa krovoobrashcheniia u krys.