Compatibility and stability of fentanyl admixtures in polypropylene syringes.
OBJECTIVE
To determine the physicochemical stability of fentanyl in combination with midazolam and either hyoscine butylbromide or metoclopramide, and stored in 30 ml polypropylene syringes.


METHODS
Solutions containing approximately 40 microg/ ml of fentanyl in combination with midazolam (approximately 600 microg/ml) and either metoclopramide (approximately 700 microg/l) or hyoscine (approximately 850 microg/ml) were prepared from commercial ampoules of the drugs. The solutions were stored, in triplicate, in the dark at 32 degrees C (to simulate usage conditions) for 10 days, and the concentration of each constituent drug was periodically determined using a stability-indicating high-performance liquid chromatography assay.


RESULTS
The combinations were relatively stable, with all drugs maintaining over 90% of their initial chemical potency for at least 1 week. There were no evident changes in either the physical appearance or pH values of the solutions over the course of the study.


CONCLUSIONS
On the basis of physicochemical stability, polypropylene syringes containing fentanyl with midazolam and either hyoscine butylbromide or metoclopramide can be safely prepared and stored at or below 32 degrees C for periods of up to 1 week prior to use by palliative care patients receiving the drugs via a portable subcutaneous infusion device.
Peterson
G M
GM
Tasmanian School of Pharmacy, University of Tasmania, Hobart, Australia.
Miller
K A
KA
Galloway
J G
JG
Dunne
P F
PF
D000759:Adjuvants, Anesthesia / Q000032:analysis / Q000737:chemistry*; D018686:Anesthetics, Intravenous / Q000032:analysis / Q000737:chemistry*; D000932:Antiemetics / Q000032:analysis / Q000737:chemistry; D004338:Drug Combinations; D004355:Drug Stability; D004356:Drug Storage; D005283:Fentanyl / Q000032:analysis / Q000737:chemistry*; D006801:Humans; D008787:Metoclopramide / Q000032:analysis / Q000737:chemistry*; D008874:Midazolam / Q000032:analysis / Q000737:chemistry*; D010166:Palliative Care; D011126:Polypropylenes / Q000737:chemistry*; D012601:Scopolamine / Q000032:analysis / Q000737:chemistry*; D013594:Syringes; D013696:Temperature
D000759:Adjuvants, Anesthesia; D018686:Anesthetics, Intravenous; D000932:Antiemetics; D004338:Drug Combinations; D011126:Polypropylenes; D012601:Scopolamine; D008787:Metoclopramide; D008874:Midazolam; D005283:Fentanyl