[Treatment of the nephrotoxicity of immunosuppressive drugs with insulin-like growth factor-I].
BACKGROUND
Delayed graft function is a common and severe complication after cadaveric kidney transplantation. Besides a more complicated postoperative course, DGF can worsen the overall graft survival. In particular, DGF enhances the nephrotoxicity of mainstream immunosuppressants cyclosporine and FK506. This study evaluates a new therapeutical approach to the treatment of DGF related nephrotoxicity, based on the administration of IGF-I.


METHODS
Sixty inbred Lewis rats underwent a bilateral clamping of the renal pedicles (20') as standard damage. The animals were stratified in six groups, according to the postoperative treatment. Group 1 served as control and received only the standard ischemic injury. Cyclosporine and FK506 were added in groups 3 and 5. Groups 2, 4 and 6 had the same treatment of groups 1, 3, 5 respectively, plus the administration of IGF-I. Blood samples were drawn daily to evaluate creatinine and BUN for 7 days.


RESULTS
The rats treated with IGF-I had significantly better values compared to the respective controls (2-way ANOVA, p < 0.05).


CONCLUSIONS
In conclusion, IGF-I improves the nephrotoxicity of mainstream immunosuppressants in this model. Its use is potentially beneficial for transplantation.
Dipartimento di Chirurgia, Università degli Studi, Pavia.
M
M
Maestri
P
P
Dionigi
P
P
Pettenazza
F
F
Visconti
J
J
Rademacher
A
A
Gaspari
F
F
Innocente
C
C
Matteotti
F
F
Luzzana
A
A
Zonta
D000818:Animals; D016572:Cyclosporine / Q000009:adverse effects; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007334:Insulin-Like Growth Factor I / Q000627:therapeutic use*; D007668:Kidney / Q000187:drug effects*; D007674:Kidney Diseases / Q000628:therapy*; D016030:Kidney Transplantation; D008297:Male; D011183:Postoperative Complications / Q000628:therapy*; D051381:Rats; D011917:Rats, Inbred Lew; D016559:Tacrolimus / Q000009:adverse effects
D007166:Immunosuppressive Agents; D007334:Insulin-Like Growth Factor I; D016572:Cyclosporine; D016559:Tacrolimus
Trattamento della nefrotossicità da farmaci immunosoppressori con insulin-like growth factor-I.