Naloxone-precipitated morphine withdrawal induced place aversions: effect of naloxone at 24 hours postmorphine.
The aversive properties of naloxone-precipitated withdrawal from acutely administered morphine were assessed using the place-conditioning paradigm. The conditioned place aversion produced by naloxone (0.5-1.0 mg/kg, s.c.) after two conditioning trials was enhanced by pretreatment with morphine (20 mg/kg, s.c.) 24 h prior to the conditioning trial. Naloxone precipitated withdrawal from acutely administered morphine produces an aversive motivational state that becomes associated with place cues.
Parker
L A
LA
Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada.
Joshi
A
A
D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000494:pharmacology*; D009294:Narcotics / Q000494:pharmacology*; D011597:Psychomotor Performance / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013375:Substance Withdrawal Syndrome; D013649:Taste
D009292:Narcotic Antagonists; D009294:Narcotics; D009270:Naloxone; D009020:Morphine