Quinolinic acid and sigma receptor ligand: effect on pyramidal neurons of the CA1 sector of dorsal hippocampus following peripheral administration in rats.
Male Wistar rats, weighing 200-220 g, were used in the study. Quinolinic acid and racemic pentazocine were administered alone or together. Quinolinic acid was administered intraperitoneally (i.p.) in a dose of 60 mmol, racemic pentazocine intramuscularly in a dose of 2 mg/kg, once every 24 h for 8 days. The control group received 1 ml of saline i.p. once daily for 8 days. Pentazocine alone produced no signs of alteration in the hippocampal formation. Quinolinic acid produced neurotoxic effect in the CA1 area of the hippocampal formation. The presence of the dark-degenerated pyramidal cells was a common sign of a delayed excitotoxic effect. Pentazocine added to quinolinic acid markedly attenuated the neurotoxic effect of quinolinic acid. In such cases, only single dark degenerated cells were seen.
Laboratory of Histochemistry, Medical Centre of Postgraduate Education, Warszawa.
M
M
Beskid
Z
Z
Rózycka
A
A
Taraszewska
D000701:Analgesics, Opioid / Q000493:pharmacokinetics*; D000818:Animals; D015220:Calcium Channels / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism*; D008024:Ligands; D008297:Male; D016202:N-Methylaspartate / Q000378:metabolism; D010423:Pentazocine / Q000493:pharmacokinetics*; D017966:Pyramidal Cells / Q000378:metabolism*; D017378:Quinolinic Acid / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D017480:Receptors, sigma / Q000378:metabolism*
D000701:Analgesics, Opioid; D015220:Calcium Channels; D008024:Ligands; D017480:Receptors, sigma; D016202:N-Methylaspartate; D017378:Quinolinic Acid; D010423:Pentazocine