The amyloid precursor protein (APP) and the angiotensin converting enzyme (ACE) secretase are inhibited by hydroxamic acid-based inhibitors.
School of Biochemistry and Molecular Biology, University of Leeds, UK.
S
S
Parvathy
I
I
Hussain
E H
EH
Karran
A J
AJ
Turner
N M
NM
Hooper
D053829:Amyloid Precursor Protein Secretases; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D016282:Aspartic Acid Endopeptidases; D002460:Cell Line; D002478:Cells, Cultured; D010450:Endopeptidases / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D006877:Hydroxamic Acids / Q000494:pharmacology*; D007703:Peptidyl-Dipeptidase A / Q000096:biosynthesis*; D010649:Phenylalanine / Q000031:analogs & derivatives / Q000494:pharmacology; D011480:Protease Inhibitors / Q000494:pharmacology*; D011499:Protein Processing, Post-Translational / Q000187:drug effects*; D013876:Thiophenes / Q000494:pharmacology; D014471:Umbilical Veins
D016564:Amyloid beta-Protein Precursor; C088670:BB 2116; D006877:Hydroxamic Acids; D011480:Protease Inhibitors; D013876:Thiophenes; D010649:Phenylalanine; C080985:batimastat; C100342:marimastat; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D007703:Peptidyl-Dipeptidase A; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human; C077675:angiotensin converting enzyme secretase