Inhibitory effect of Hesperidin on tumour initiation and promotion in mouse skin.
A flavonoid, Hesperidin was evaluated for its ability to inhibit tumour initiation by a polycyclic aromatic hydrocarbon and tumour promotion by a phorbol ester in the skin of CD-1 mice. Subcutaneous application of Hesperidin did not inhibit 7,12-dimethylbenz(a)anthracene-induced tumour initiation but did inhibit 12-O-tetradecanoyl-13-phorbol acetate-induced tumour promotion. Results provide evidence for a potential chemopreventive activity of Hesperidin.
Department of Haematology, Istanbul University, Cerrahpasa Medical School, Turkey.
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B
Berkarda
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H
Koyuncu
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G
Soybir
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F
Baykut
D015127:9,10-Dimethyl-1,2-benzanthracene; D000279:Administration, Cutaneous; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D002273:Carcinogens; D004336:Drug Antagonism; D005260:Female; D006569:Hesperidin / Q000008:administration & dosage*; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D013755:Tetradecanoylphorbol Acetate
D000970:Antineoplastic Agents; D002273:Carcinogens; D015127:9,10-Dimethyl-1,2-benzanthracene; D006569:Hesperidin; D013755:Tetradecanoylphorbol Acetate