[Paraneoplastic intestinal pseudo-obstruction revealing small cell lung carcinoma: "the anti-Hu syndrome"].
A 67-year-old woman was admitted for intestinal pseudoobstruction associated with peripheral sensitive neuropathy. Jejunal biopsies performed during laparotomy, showed axonal degeneration and lympho-plasmocytic infiltration in myenteric plexus. High titer of seric anti-Hu antibodies suggested a paraneoplastic syndrome. Thoracic CT scan showed mediastinal lymph nodes. Their histological examination confirmed the diagnosis of metastatic small-cell lung carcinoma. Her condition gradually deteriorated despite supportive parenteral nutrition, chemotherapy, steroids and intravenous immunoglobulins. She died 12 months after the onset of symptoms.
Service de Gastroentérologie, Hôpital Saint-Lazare, Paris.
E
E
Cuillerier
B
B
Coffin
F
F
Potet
M
M
Dapoigny
B
B
Flourie
J C
JC
Coffin
B
B
Benyahia
A
A
Bitoun
B
B
Messing
J C
JC
Rambaud
D000368:Aged; D000906:Antibodies / Q000032:analysis; D001706:Biopsy; D018288:Carcinoma, Small Cell / Q000150:complications* / Q000276:immunology / Q000473:pathology; D051959:ELAV Proteins; D005260:Female; D006801:Humans; D007418:Intestinal Pseudo-Obstruction / Q000150:complications* / Q000276:immunology; D007583:Jejunum / Q000294:innervation / Q000473:pathology; D007813:Laparotomy; D008175:Lung Neoplasms / Q000150:complications* / Q000276:immunology / Q000473:pathology; D009419:Nerve Tissue Proteins; D010257:Paraneoplastic Syndromes / Q000150:complications* / Q000276:immunology; D016601:RNA-Binding Proteins / Q000276:immunology*; D013902:Radiography, Thoracic; D012183:Retrograde Degeneration; D014057:Tomography, X-Ray Computed
D000906:Antibodies; D051959:ELAV Proteins; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins
Pseudo-obstruction intestinale paranéoplasique révélatrice d'un carcinome pulmonaire à petites cellules: le syndrome anti-Hu.