[Hormonal regulation of heparin secretion by rat mast cells during stress].
Administration of non-selective beta-blocker propranolol prevented the stress-activated action whereas the alpha-agonist isoprenaline enhanced the effect of immobilisation stress on the rat mast cells. beta-antagonists or agonists exerted no effect on the heparine secretion by the mast cells. ACTH activated the secretion in the absence of stress.
Moscow State University, Vorobyevy Gory, Russia.
F B
FB
Shapiro
B A
BA
Umarova
S M
SM
Strukova
D000322:Adrenergic Agonists / Q000494:pharmacology; D018674:Adrenergic Antagonists / Q000494:pharmacology; D000324:Adrenocorticotropic Hormone / Q000037:antagonists & inhibitors / Q000502:physiology*; D000818:Animals; D002395:Catecholamines / Q000502:physiology*; D006493:Heparin / Q000378:metabolism*; D007103:Immobilization; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D018343:Receptors, Adrenergic, beta-2 / Q000187:drug effects / Q000502:physiology; D013312:Stress, Physiological / Q000503:physiopathology*
D000322:Adrenergic Agonists; D018674:Adrenergic Antagonists; D002395:Catecholamines; D018343:Receptors, Adrenergic, beta-2; D000324:Adrenocorticotropic Hormone; D006493:Heparin
Gormonal'naia reguliatsiia sekretsii geparina tuchnymi kletkami krys pri stressornykh vozdeĭstviiakh.