Relationship of neurological function and age in older women. The study of osteoporotic fractures.
The decline of neurological and neuromuscular function with age in older women and in subgroups of older women with selected risk factors for poor function is described using cross- sectional analyses of data on 8,080 women from the multicenter Study of Osteoporotic Fractures. All twelve performance-based tests of muscle strength, balance, gait, somatosensory discrimination and reaction time declined with increasing age. On a percentage scale, vibration threshold declined the most rapidly with age. Participants who were smokers, physically inactive, nonconsumers of alcohol, diabetics and more frequent fallers had poorer age-adjusted performance than those without these attributes. However, with a few exceptions, the rate of decline in performance with age for those with and without these characteristics did not differ significantly.
Division of Epidemiology, Department of Health Research and Policy, Stanford University School of Medicine, Stanford, Calif., USA. MSands1111@aol.com
M L
ML
Sands
A V
AV
Schwartz
B W
BW
Brown
M C
MC
Nevitt
D G
DG
Seeley
J L
JL
Kelsey
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D005260:Female; D005684:Gait; D018737:Hand Strength / Q000502:physiology; D006801:Humans; D018482:Muscle, Skeletal / Q000503:physiopathology; D009424:Nervous System Physiological Phenomena; D009460:Neurologic Examination; D015663:Osteoporosis, Postmenopausal / Q000453:epidemiology / Q000503:physiopathology*; D011930:Reaction Time / Q000502:physiology; D012307:Risk Factors; D012684:Sensory Thresholds / Q000502:physiology; D011795:Surveys and Questionnaires; D014110:Touch / Q000502:physiology; D014481:United States / Q000453:epidemiology