Trisomy 5 in two cases of acute monocytic leukemia with hyperdiploid clones.
Although numerical chromosomal aberrations are commonly seen in acute myeloid leukemia (AML), trisomy 5 (+ 5) is very rarely detected. We report two patients, both of whom suffered from acute monocytic leukemia, in which + 5 was found in hyperdiploid clones. A review of the English literature shows 17 additional cases of AML with + 5 in at least one of the abnormal clones, making a total of 19 such cases including ours. Trisomy 5 has been reported in all FAB subtypes of AML except acute promyelocytic leukemia. In the 19 cases identified in this report, + 5 was found in association with other numerical changes (four cases), structural changes (five cases) or both (eight cases). Trisomy 5 as a sole karyotypic abnormality was exceedingly rare (two cases). Its biologic and prognostic significance remains to be determined.
Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong. eskma@hkucc.hku.hk
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D000328:Adult; D002895:Chromosomes, Human, Pair 5; D002999:Clone Cells; D004171:Diploidy; D005260:Female; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014314:Trisomy