Accurate spike synchronization in cortex.
In view of the enormous capacity and complexity of mammalian brains it is evident that a detailed account of their anatomy and physiology alone cannot lead to a complete understanding of their function. Computer simulation and mathematical analysis of abstract, yet biologically realistic models for neurons and networks yield additional and useful information about the interplay of the underlying anatomical structures, the physiological processes operating on the neuronal substrate, and the resulting brain functions during the performance of behavioral tasks. We discuss some contributions of such experiment-guided theory to the issue of accurate spike synchronization.
Rotter
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S
Institut für Biologie III-Neurobiologie & Biophysik, Universität Freiburg, Germany. rotter@biologie.uni-freiburg.de
Aertsen
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A
D000818:Animals; D001519:Behavior / Q000502:physiology; D001522:Behavior, Animal / Q000502:physiology; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000502:physiology*; D003198:Computer Simulation; D019706:Excitatory Postsynaptic Potentials; D006801:Humans; D008322:Mammals; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D013269:Stochastic Processes; D013997:Time Factors