[Parenteral nutrition of patients under intensive chemotherapy: comparative study of two lipid emulsions].
Neoplastic patients receiving intensive chemotherapy often need total parenteral nutrition (TPN), with lipid emulsions based on long-chain triglycerides (LCT) or medium-chain triglycerides (MCT). Potential benefits of MCT include easier metabolism and limited storage. Our present investigation was performed to define if there is any real clinical advantage of any of these lipid emulsions in this group of patients. Fifty-one patients receiving the LCT emulsion and sixty of them receiving the MCT-LCT one were evaluated retrospectively. TPN with 40% of non-protein kilocalories as fat was administered during a mean time of 11.5 days. No differences in total cholesterol, albumin, prealbumin, transferrin, bilirubin, alkaline phosphatase, gamma-glutamyl transpeptidase and transaminases were found between both groups, neither in nitrogen balances. In conclusion, in a group of neoplastic patients receiving intensive chemotherapy, we did not found any advantage of TPN with LCT or MCT-LCT either in nutritional laboratory parameters or in liver function.
Servicios de Endocrinología y Nutrición y Oncología Médica, Hospital Universitario San Carlos, Madrid, España.
M D
MD
Ballesteros
M A
MA
Rubio
M J
MJ
Redondo
L
L
Cabrerizo
S
S
Romeo
J L
JL
Alonso
Y L
YL
Nieto
F
F
Ayala
M
M
Martín
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000188:drug therapy*; D010288:Parenteral Nutrition; D014280:Triglycerides / Q000008:administration & dosage
D005217:Fat Emulsions, Intravenous; D014280:Triglycerides
Nutrición parenteral en pacientes con quimioterapia intensiva: estudio comparativo de dos emulsiones lipídicas.