[The toxicology and prevention of the risks of occupational exposure to aromatic polycyclic hydrocarbons. III. The effects: epidemiological evidence, early effects. Individual hypersusceptibility. Health surveillance].
Adverse effects following occupational exposure to polycyclic aromatic hydrocarbons (PAH) are mainly carcinogenic. The available epidemiological data suggest that some substances and industrial processes, in which PAH exposure is frequent, are classified as carcinogenic to humans: primary aluminium industry, cola gasification, coke production, iron and steel foundry, coal tar, pitch, creosote, untreated mineral oils, asphalt, soot. The target organs are mainly lung, bladder, skin. Other relevant effects are skin lesions such as folliculitis. The studies on early biological effects (chromosomal aberrations, sister chromatid exchanges, micronuclei) have shown contradictory results, mainly because of differences in exposure intensity. The metabolic polymorphism may account for a higher susceptibility to lung and bladder cancer following exposure to risk factors; the role of PAH occupational exposure is however to be examined, and the use of indicators of genetic susceptibility is currently limited to research programs. Health surveillance for PAH exposed workers is funded on the Italian laws (DPR 303/56 and D.Lgs. 626/94) and it is mainly dedicated to prevention of carcinogenic effects. Preventive examinations should consider PAH target organs (skin, lung, bladder, larynx) and look for early signs and symptoms. Particular attention will be paid to life habits such as tobacco smoking or diseases which could represent condition of susceptibility. Periodical examinations (every six months) will similarly evaluate PAH target organs. Health surveillance is also programmed for formerly exposed workers and the institution of exposure and cancer registries is mandatory. On the basis of the current scientific data, it is not advisable the use of tumor markers or cytogenetic tests at the individual level as well as the screening of asymptomatic PAH exposed workers for early diagnosis of lung or bladder cancer. Information and formation activities will be part of medical examinations and will be included in specific programs in cooperation with other company functions.
Porru
S
S
Cattedra di Medicina del Lavoro, Università di Brescia.
Assennato
G
G
Bergamaschi
E
E
Carta
P
P
Foà
V
V
Forni
A
A
Gabbani
G
G
Mastrangelo
G
G
Sartorelli
P
P
D002273:Carcinogens / Q000633:toxicity; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000139:chemically induced; D009784:Occupational Diseases / Q000139:chemically induced; D016273:Occupational Exposure / Q000009:adverse effects / Q000517:prevention & control*; D011084:Polycyclic Aromatic Hydrocarbons / Q000633:toxicity*; D011159:Population Surveillance / Q000379:methods; D012307:Risk Factors; D013997:Time Factors
D002273:Carcinogens; D011084:Polycyclic Aromatic Hydrocarbons
Tossicologia e prevenzione dei rischi da esposizione professionale a idrocarburi policiclici aromatici. III. Effetti: evidenze epidemiologiche, effetti precoci. Ipersuscettibilità individuale. Sorveglianza sanitaria.