Fixed drug eruption induced by indapamide. Cross-reactivity with sulfonamides.
Indapamide is a nontiazidic sulfonamide diuretic which has not been previously reported as a cause of fixed drug eruption. We describe a patient who experienced several episodes of fixed drug eruption during treatment with indapamide. The diagnosis was confirmed by positive controlled oral challenge test. The possible existence of cross-reactivity with other sulfonamide derivatives was investigated by controlled oral challenge test with sulfamethoxazole, sulfadiazine and furosemide, with the tests with sulfamethoxazole and sulfadiazine resulting positive.
Section of Allergology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
M
M
De Barrio
P
P
Tornero
J M
JM
Zubeldia
Z
Z
Sierra
V
V
Matheu
T
T
Herrero
D000368:Aged; D000959:Antihypertensive Agents / Q000009:adverse effects / Q000276:immunology*; D003429:Cross Reactions; D003875:Drug Eruptions / Q000276:immunology* / Q000473:pathology; D004342:Drug Hypersensitivity / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D007190:Indapamide / Q000009:adverse effects / Q000276:immunology*; D013449:Sulfonamides / Q000276:immunology*
D000959:Antihypertensive Agents; D013449:Sulfonamides; D007190:Indapamide