Subchronic oral hepatotoxicity of turmeric in mice--histopathological and ultrastructural studies.
Dietary administration of the whole spice turmeric (0.2%, 1.0%, 5.0%) or ethanolic turmeric extract (ETE, 0.05%, 0.25%) for 14 days, at doses reported to be cancer preventive in model systems, were found to be hepatotoxic in mice. Histopathological evaluation showed coagulative necrosis accompanied by a zone of regenerating parenchymal cells of liver. The ultrastructural changes in liver parenchymal cells were non-specific reaction to injury. Results suggest mouse to be a susceptible species for turmeric induced toxicity.
Kandarkar
S V
SV
Cell Biology Division, Tata Memorial Centre, Mumbai, India.
Sawant
S S
SS
Ingle
A D
AD
Deshpande
S S
SS
Maru
G B
GB
D000284:Administration, Oral; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D003212:Condiments / Q000009:adverse effects*; D030024:Curcuma; D005260:Female; D051379:Mice; D008854:Microscopy, Electron; D010936:Plant Extracts / Q000009:adverse effects*
D010936:Plant Extracts; C012596:turmeric extract