Alkalinization and hemodialysis in severe salicylate poisoning: comparison of elimination techniques in the same patient.
We report the case of a man who took two overdoses of aspirin, on each occasion suffering a grand mal fit with blood levels of salicylate of over 5 mmol/l. The first event was treated with hemodialysis but without effective alkalinization, and the second with alkalinization but without hemodialysis. The rate of decline in salicylate concentration was faster with alkalinization in the first 4 hours. Similar salicylate levels were achieved with both techniques by 24 hours post-overdose. If a case of salicylate poisoning is to be treated with hemodialysis, treatment with alkalinization should still be given without delay, in order to prevent acidemia and to promote elimination of as much salicylate as possible via the kidneys.
Higgins
R M
RM
Renal Unit, King's College Hospital, London, UK.
Connolly
J O
JO
Hendry
B M
BM
D000208:Acute Disease; D000328:Adult; D000435:Alcoholic Intoxication / Q000150:complications; D001241:Aspirin / Q000506:poisoning*; D001714:Bipolar Disorder / Q000150:complications; D062787:Drug Overdose / Q000628:therapy; D004830:Epilepsy, Tonic-Clonic / Q000139:chemically induced / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011041:Poisoning / Q000628:therapy; D012008:Recurrence; D006435:Renal Dialysis / Q000379:methods*
D001241:Aspirin