Nicotine availability from Eclipse tobacco-heating cigarette.
A cigarette which heats rather than burns tobacco (Premier) was introduced in 1988, but was unacceptable due to unpleasant taste and low nicotine intake. We examined availability of nicotine from a new version (Eclipse), in the same four subjects as our earlier Premier study. Average blood nicotine boosts of 23.7 and 17.8 ng/ml were obtained from smoking a first and second Eclipse. This substantially exceeds intake from Premier (boost 13 ng/ml) and that obtained by heavy smokers from conventional brands (boost 12-15 ng/ml). Eclipse (or similar product) may be the best option for averting Peto's dire warnings of rising millions of annual smoking deaths in the 2020s, and its potential for large-scale, long-term switching warrants further study.
Institute of Psychiatry, Tobacco Research Section, National Addiction Centre, London, UK. j.stapleton@iop.bpmf.ac.uk
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Stapleton
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Russell
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Sutherland
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Feyerabend
D000328:Adult; D004244:Dizziness / Q000139:chemically induced; D005069:Evaluation Studies as Topic; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D009538:Nicotine / Q000097:blood* / Q000494:pharmacology; D018722:Nicotinic Agonists / Q000097:blood* / Q000494:pharmacology; D012907:Smoking / Q000009:adverse effects
D018722:Nicotinic Agonists; D009538:Nicotine