Preliminary X-ray crystallographic studies of a newly defined human theta-class glutathione transferase.
Human theta-class glutathione S-transferases (GST's) appear to play a critical role in the metabolism of a variety of environmental pollutants but in some cases the products of the reaction are carcinogenic. Crystals of a human theta-class GST, namely hGSTT2-2, have been grown from polyethylene glycol by the hanging-drop vapour-diffusion method. The crystals belong to the trigonal space group P3121 with cell dimensions of a = b = 94.0 and c = 120.5 A. They contain two monomers in the asymmetric unit and diffract to 3.0 A resolution.
The Ian Potter Foundation Protein Crystallography Laboratory, St Vincent's Institute of Medical Research, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia.
W J
WJ
McKinstry
A J
AJ
Oakley
J
J
Rossjohn
D
D
Verger
K L
KL
Tan
P G
PG
Board
M W
MW
Parker
D003460:Crystallization; D018360:Crystallography, X-Ray; D004058:Diffusion; D005982:Glutathione Transferase / Q000737:chemistry* / Q000235:genetics; D006801:Humans; D005810:Multigene Family
C491107:GSTT2 protein, human; D005982:Glutathione Transferase