Trisomy 5 in two cases of acute monocytic leukemia with hyperdiploid clones.
Although numerical chromosomal aberrations are commonly seen in acute myeloid leukemia (AML), trisomy 5 (+ 5) is very rarely detected. We report two patients, both of whom suffered from acute monocytic leukemia, in which + 5 was found in hyperdiploid clones. A review of the English literature shows 17 additional cases of AML with + 5 in at least one of the abnormal clones, making a total of 19 such cases including ours. Trisomy 5 has been reported in all FAB subtypes of AML except acute promyelocytic leukemia. In the 19 cases identified in this report, + 5 was found in association with other numerical changes (four cases), structural changes (five cases) or both (eight cases). Trisomy 5 as a sole karyotypic abnormality was exceedingly rare (two cases). Its biologic and prognostic significance remains to be determined.
Ma
S K
SK
Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong. eskma@hkucc.hku.hk
Wan
T S
TS
Au
W Y
WY
Chan
L C
LC
D000328:Adult; D002895:Chromosomes, Human, Pair 5; D002999:Clone Cells; D004171:Diploidy; D005260:Female; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014314:Trisomy