Plasma levels of type II phospholipase A2 and nitrite/nitrate in patients with burns.
Type II phospholipase A2 (type II PLA2), nitrite/nitrate (NOx), tumor necrosis factor-alpha (TNF-alpha) and endotoxin were studied in burn patients. Type II PLA2 values and NOx values were both significantly higher in the group that died, the group with shock as a complication and the group with multiple organ dysfunction syndrome (MODS) as a complication, than in the group that survived, the group without shock as a complication and the group without MODS as a complication, respectively. The results suggested that type II PLA2 and nitric oxide (NO) may play a major role in the pathology of burn patients. Significant correlations were found between TNF-alpha and type II PLA2 values and between type II PLA2 and NOx values, suggesting the possibility of involvement in each other's production.
Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.
Y
Y
Yamada
S
S
Endo
Y
Y
Kamei
T
T
Minato
M
M
Yokoyama
S
S
Taniguchi
H
H
Nakae
K
K
Inada
M
M
Ogawa
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002056:Burns / Q000097:blood* / Q000150:complications; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D054501:Group II Phospholipases A2; D006801:Humans; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000097:blood / Q000209:etiology / Q000401:mortality; D009566:Nitrates / Q000097:blood*; D009569:Nitric Oxide / Q000378:metabolism; D009573:Nitrites / Q000097:blood*; D010741:Phospholipases A / Q000097:blood*; D054467:Phospholipases A2; D012772:Shock, Septic / Q000097:blood / Q000150:complications / Q000401:mortality; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D015415:Biomarkers; D009566:Nitrates; D009573:Nitrites; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide; D010741:Phospholipases A; D054501:Group II Phospholipases A2; D054467:Phospholipases A2