[Necrobiotic xanthogranulomatosis: a cutaneous manifestation of a monoclonal IgM gammopathy].
BACKGROUND
Necrobiotic xanthogranulomatosis is a rare cutaneous disorder usually associated with monoclonal gammopathy. Most frequently, cutaneous lesions involve the face (periorbital region) and the trunk, and are characterized by indurated xanthomatous plaques and nodules.


METHODS
We describe a patient presenting with necrobiotic xanthogranulomatosis that was unusual, as it was associated with IgM kappa monoclonal gammopathy of undetermined clinical significance and because no periorbital involvement was observed.


CONCLUSIONS
Necrobiotic xanthogranulomatosis should be distinguished from other cutaneous manifestations associated with plasma cell dyscrasias, such as normolipemic plane xanthoma. It can be associated with IgM gammopathy.
Service de médecine interne, Centre Hospitalier Lyon-Sud, Pierre-Bénite, France.
P
P
Sève
T
T
Zénone
I
I
Durieu
G
G
Moulin
R
R
Levrat
D003449:Cryoglobulinemia / Q000150:complications; D006099:Granuloma / Q000209:etiology*; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications*; D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains; D008297:Male; D008875:Middle Aged; D017441:Necrobiotic Disorders / Q000209:etiology*; D012871:Skin Diseases / Q000209:etiology*; D014973:Xanthomatosis / Q000209:etiology*
D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains
Xanthogranulomatose nécrobiotique: manifestation cutanée d'une IgM monoclonale.