Orphanin FQ stimulates prolactin and growth hormone release in male and female rats.
Intracerebroventricular administration of Orphanin FQ (5.5, 55 or 550 pmol) caused a dose-related increase in prolactin secretion in both male and female rats and stimulated GH secretion in males. The magnitude of the prolactin secretory response was greater in females than in males. These effects of OFQ on prolactin and growth hormone release are the same as the stimulatory effects of the endogenous opioid peptides.
Miami University, Department of Zoology, Center for Neuroscience, 290 Pearson Hall, Oxford, OH 45056, USA.
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Bryant
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Janik
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Baumann
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Callahan
D000704:Analysis of Variance; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D013006:Growth Hormone / Q000378:metabolism*; D008297:Male; D018847:Opioid Peptides / Q000494:pharmacology*; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011957:Receptors, Opioid / Q000819:agonists*; D013268:Stimulation, Chemical; D000097629:Nociceptin
D013006:Growth Hormone; D018847:Opioid Peptides; D011388:Prolactin; D011957:Receptors, Opioid; D000097629:Nociceptin