Alpha and beta subunits of CaM-kinase II are localized in different neurons in chick ciliary ganglion.
The ciliary ganglion of the chicken contains only two types of neurons. Using monoclonal antibodies against the alpha and the beta subunits of Ca2+/calmodulin-stimulated protein kinase II (CaMPK-II) we found that the alpha-subunit was localized to the choroid neurons while beta subunit was associated with the ciliary neurons. As both neurons receive their inputs from the oculomotor nerve, while their postganglionic axons leave via different nerves, the ciliary ganglion of the chicken is a neuronal system in which the functional differences between alpha and beta CaMPK-II homopolymers in the regulation of synaptic transmission can be investigated.
The Neuroscience Group, Faculty of Medicine and Health Sciences, University of Newcastle, NSW, Australia.
I
I
Lengyel
K A
KA
Nichol
M R
MR
Bennett
J W
JW
Heath
G J
GJ
Little
J A
JA
Rostas
D000818:Animals; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000378:metabolism*; D002645:Chickens / Q000502:physiology*; D005726:Ganglia, Parasympathetic / Q000166:cytology* / Q000201:enzymology*; D007150:Immunohistochemistry; D017774:Long-Term Potentiation / Q000502:physiology; D009474:Neurons / Q000201:enzymology*
D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D017871:Calcium-Calmodulin-Dependent Protein Kinases