A comparative study on the efficacy of the new quinolone alatrofloxacin in the treatment of experimental legionellosis in guinea pigs.
The in vivo efficacy of trovafloxacin, intraperitoneally administered as alatrofloxacin (CP-116,517), was assessed and compared with that of erythromycin, alone or in combination with rifampicin, in a model of Legionella pneumophila pneumonia in guinea pigs. Trovafloxacin (5 mg/kg administered as alatrofloxacin once daily for 7 days) gave a survival rate of 100% in infected animals. Clearance of bacteria and of bacteria-induced lesions from lungs was achieved by day 6 post-inoculation. The lungs of trovafloxacin-treated animals remained free of bacteria at day 28 post-challenge. Trovafloxacin proved as effective as erythromycin administered intraperitoneally, but was superior to erythromycin alone. or in combination with rifampicin, when given orally.
Department of Microbiology, Faculty of Medicine, Hospital Clinic, Valencia, Spain.
J
J
García-de-Lomas
E
E
Millás
M A
MA
Lázaro
M
M
Bermejo
C
C
Gimeno
D
D
Navarro
S
S
Sánchez
D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination / Q000008:administration & dosage / Q000627:therapeutic use; D004917:Erythromycin / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D024841:Fluoroquinolones; D006168:Guinea Pigs; D007274:Injections, Intraperitoneal; D016952:Legionella pneumophila / Q000187:drug effects; D007877:Legionnaires' Disease / Q000188:drug therapy* / Q000382:microbiology; D008168:Lung / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D011355:Prodrugs / Q000627:therapeutic use*; D011897:Random Allocation; D012293:Rifampin / Q000008:administration & dosage / Q000627:therapeutic use
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D011355:Prodrugs; D004917:Erythromycin; C106856:alatrofloxacin; D012293:Rifampin