The cholinergic locus: ChAT and VAChT genes.
The gene encoding the vesicular acetylcholine transporter has been localized within the first intron of the gene encoding choline acetyltransferase and is in the same transcriptional orientation. These two genes, whose products are required for the expression of the cholinergic phenotype, could therefore be coregulated. The promoters of both genes have been identified. The mechanisms that account for the regulation of the expression of both genes are now being investigated.
CNRS, Laboratoire de Génétique de la Neurotransmission et des Processus Neurodégénératifs, Hôpital Pitié-Salpétrière, Paris, France.
J
J
Mallet
L
L
Houhou
F
F
Pajak
Y
Y
Oda
R
R
Cervini
S
S
Bejanin
S
S
Berrard
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D002352:Carrier Proteins / Q000235:genetics*; D002795:Choline O-Acetyltransferase / Q000235:genetics*; D005786:Gene Expression Regulation; D007438:Introns; D026901:Membrane Transport Proteins; D011401:Promoter Regions, Genetic; D051381:Rats; D014158:Transcription, Genetic; D050494:Vesicular Acetylcholine Transport Proteins; D033921:Vesicular Transport Proteins
D002352:Carrier Proteins; D026901:Membrane Transport Proteins; C493461:Slc18a3 protein, rat; D050494:Vesicular Acetylcholine Transport Proteins; D033921:Vesicular Transport Proteins; D002795:Choline O-Acetyltransferase; D000109:Acetylcholine