Effects of thiamin and methionine administration in preventing cadmium-induced biochemical alterations and metal concentration in male rats.
Thiamin or methionine supplementation was equally and moderately effective in preventing the accumulation of cadmium in soft organs and alterations in a few selected biochemical indices during concomitant administration. Adequate intake of sulfur amino acid following methionine supplementation might increase the bioavailability of glutathione, facilitating the prevention of the binding of cadmium to different compartments and consequently reversing cadmium-induced biochemical disorders. In the case of thiamine the possibility of formation of a readily excretable complex between cadmium and thiamine or an increase in the body's resistance to cadmium might be the beneficial factor.
Gubrelay
U
U
School of Studies in Zoology, Jiwaji University, Gwalior, India.
Srivastava
P
P
Mathur
R
R
Tripathi
N
N
Flora
S J
SJ
D000042:Absorption; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002104:Cadmium / Q000493:pharmacokinetics* / Q000633:toxicity*; D002105:Cadmium Poisoning / Q000097:blood / Q000378:metabolism / Q000517:prevention & control*; D004347:Drug Interactions; D007668:Kidney / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008297:Male; D008668:Metallothionein / Q000378:metabolism; D008715:Methionine / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013831:Thiamine / Q000627:therapeutic use*; D005723:gamma-Glutamyltransferase / Q000097:blood
D002104:Cadmium; D008668:Metallothionein; D008715:Methionine; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D013831:Thiamine