Differential expression of the murine Ly-6A/E antigen homolog of human squamous cell carcinoma antigen E48 during malignant transformation and tumor progression of squamous cell carcinoma line Pam 212.
The mRNA differential display method detected increased expression of the mRNA of an immune recognition antigen known as Ly-6A/E after malignant transformation of the murine squamous cell carcinoma line Pam 212. Subsequent loss of expression of Ly-6A/E occurred with metastatic tumor progression of Pam in vivo. Ly-6 molecules have been implicated in immune cell recognition and signal transduction and are homologous to the human E48 SCC antigen that has been shown to be involved in cell-cell recognition. These observations suggest that loss of Ly-6A/E antigen may contribute to tumor progression and metastasis of squamous cell carcinoma through decreased tumor-lymphocyte or tumor-tumor recognition.
Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892-1419, USA.
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Kato
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Dong
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Loukinova
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Chen
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Van Waes
D000818:Animals; D000950:Antigens, Ly / Q000032:analysis / Q000235:genetics*; D000951:Antigens, Neoplasm / Q000032:analysis / Q000235:genetics; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000276:immunology* / Q000556:secondary; D015815:Cell Adhesion Molecules / Q000032:analysis / Q000235:genetics*; D002450:Cell Communication / Q000235:genetics; D002461:Cell Line, Transformed; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D018450:Disease Progression; D058851:GPI-Linked Proteins; D015972:Gene Expression Regulation, Neoplastic; D006023:Glycoproteins / Q000032:analysis / Q000235:genetics*; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D006801:Humans; D015603:Keratinocytes; D008214:Lymphocytes / Q000276:immunology; D008565:Membrane Proteins / Q000032:analysis / Q000235:genetics*; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D015843:Serpins / Q000032:analysis / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics; D014407:Tumor Cells, Cultured
D000950:Antigens, Ly; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules; D058851:GPI-Linked Proteins; D006023:Glycoproteins; C094237:LY6D protein, human; C074650:Ly6a protein, mouse; D008565:Membrane Proteins; D012333:RNA, Messenger; D015843:Serpins; C051072:squamous cell carcinoma-related antigen