Urocanic acid and cutaneous antigen presentation.
Exposure to UVB results in the isomerization of trans-urocanic acid (UCA), localized in the stratum corneum, to cis-UCA. Cis-UCA can mediate at least some of the immunosuppressive effects of UVB, though the mechanism of cis-UCA action remains incompletely defined. Here, we review the evidence that cis-UCA acts through alterations in cutaneous antigen presentation.
Lappin
M B
MB
Department of Dermatology, University of Freiburg, Germany. lappin@haul.ukl.uni-freiburg.de
Simon
J C
JC
D000818:Animals; D017951:Antigen Presentation; D002478:Cells, Cultured; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology / Q000528:radiation effects; D016753:Interleukin-10 / Q000096:biosynthesis; D007536:Isomerism; D011458:Prostaglandins E / Q000096:biosynthesis; D012867:Skin / Q000276:immunology* / Q000378:metabolism / Q000528:radiation effects; D014560:Urocanic Acid / Q000276:immunology* / Q000528:radiation effects / Q000652:urine
D011458:Prostaglandins E; D016753:Interleukin-10; D014560:Urocanic Acid