[Participation of glyoxalases and methylglyoxal in diabetic complication development].
The glyoxalase system catalyses the conversion of methylglyoxal to D-lactate via intermediate S-D-lactoylgutathione. This system consists of two enzymes, glyoxalase I and glyoxalase II. A link between the development of diabetic complications and the glyoxalase system has been suggested at the genetic and metabolic level. Insulin-dependent diabetic patients without complications (retinopathy, neuropathy) had a significantly higher frequency of the glyoxalase phenotype GLO 1-1 than patients with complications. Periodic hyperglycaemia may contribute to the development of diabetic complication through methylglyoxal-mediated changes in protein solubility and aggregation characteristics.
Katedry i Zakładu Biochemii i Chemii Slaskiej Akademii Medycznej w Katowicach.
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Kopieczna-Grzebieniak
D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000201:enzymology*; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology; D007791:Lactoylglutathione Lyase / Q000378:metabolism*; D011765:Pyruvaldehyde / Q000378:metabolism*
D011765:Pyruvaldehyde; D007791:Lactoylglutathione Lyase
Udział glioksalaz i metyloglioksalu w rozwoju powikłań cukrzycowych.