Molecular epidemiology of penicillin-resistant Streptococcus pneumoniae isolated in central Taiwan.
Previous studies have suggested that penicillin-resistant pneumococcal isolates (especially those with MIC > 1 microgram/mL) usually are clonally related. To test this hypothesis, the molecular epidemiology of 29 clinical isolates of penicillin-resistant pneumococci (of which 83% were also resistant to either cefotaxime or ceftriaxone) collected in central Taiwan was investigated by pulsed field gel electrophoresis. Twenty-seven distinct patterns were identified. Our results indicate that an increase in penicillin-resistant S. pneumoniae between April 1993 and June 1994 in central Taiwan is not due to the clonal dissemination of a limited number of epidemic strains.
Section of Infectious Diseases (PY-FL), Shalu Tungs' Memorial Hospital, Taiwan, Republic of China.
P Y
PY
Liu
B S
BS
Hu
C P
CP
Fung
Y J
YJ
Lau
Z Y
ZY
Shi
Y H
YH
Lin
D002439:Cefotaxime / Q000494:pharmacology; D002443:Ceftriaxone / Q000494:pharmacology; D018550:Cephalosporin Resistance; D018432:Drug Resistance, Multiple; D016521:Electrophoresis, Gel, Pulsed-Field; D006801:Humans; D008826:Microbial Sensitivity Tests; D017720:Molecular Epidemiology; D010068:Oxacillin / Q000494:pharmacology; D010403:Penicillin Resistance; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000382:microbiology; D013296:Streptococcus pneumoniae / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D013624:Taiwan / Q000453:epidemiology
D002443:Ceftriaxone; D002439:Cefotaxime; D010068:Oxacillin