An atherogenic midband lipoprotein: a risk factor for coronary artery disease in diabetes mellitus with hyperlipidemia.
On polyacrylamide gel (PAG) disc electrophoresis of serum lipoproteins, the band(s) which migrates between pre beta- and beta-lipoproteins was more frequently observed in hyperlipidemics with diabetes mellitus (73%), than in those without diabetes mellitus (37%) (P < 0.01). Those bands were seen at three positions between pre beta- and beta-lipoproteins. A higher incidence of coronary artery disease (CAD) was observed in patients with midband as a shoulder of beta-lipoproteins (44%), than in those without midband (11%) (P < 0.05) after the matching of other risk factors. These results suggest that midband as a shoulder of beta-lipoproteins may be a risk factor for CAD in diabetes mellitus with hyperlipidemia.
Kawano
M
M
Second Department of Internal Medicine, School of Medicine, Chiba University, Japan.
Shinomiya
M
M
Kanzaki
T
T
Morisaki
N
N
Shirai
K
K
Saito
Y
Y
Yoshida
S
S
D003327:Coronary Disease / Q000097:blood / Q000150:complications*; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000097:blood; D004589:Electrophoresis, Disc; D006442:Glycated Hemoglobin / Q000032:analysis; D053442:High-Density Lipoproteins, Pre-beta; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood*; D012307:Risk Factors
D006442:Glycated Hemoglobin; D053442:High-Density Lipoproteins, Pre-beta; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL