Adsorption of some technetium-99m radiopharmaceuticals onto disposable plastic syringes.
OBJECTIVE
The purpose of this study was to determine the adsorption behavior of some widely used, commercially available 99mTc radiopharmaceuticals onto different types of plastic syringes.


METHODS
Kits were reconstituted with 99mTc-pertechnetate diluted with 0.9% saline to produce maximum radioactive concentrations, as stated by the manufacturers. Aliquots of the solutions were transferred to four different brands of 2-ml syringes. The activity in the syringes was measured before and after injections or simulated injections. The amount adsorbed to the plastic syringe barrel and plunger before and after washout also was measured at different time intervals. Comparisons between products from different manufacturers were made for 99mTc succimer (DMSA) and 99mTc macroaggregated albumin (MAA).


RESULTS
Some 99mTC preparations undergo significant adsorption to plastic syringes. Adsorption differs considerably between products from different manufacturers. There was significantly higher residual activity in some types of syringes. In some cases the residual was as high as 40%-50% of the initial activity, and most of the adsorption occurred within 15 min of filling the syringe.


CONCLUSIONS
The data suggest that the extent of adsorption depends on pharmaceutical excipients in the kits and/or the type of syringe used. When inappropriate syringes are used, the reduction in the administered activity may result in poor-quality images. Therefore, the compatibility between radiopharmaceutical and syringe should be investigated under normal conditions of preparation and use every time a new brand of syringe or a new radiopharmaceutical comes into use in diagnostic nuclear medicine.
Jansson
B A
BA
Hospital Pharmacy, Huddinge University Hospital, Sweden.
Göransson
M B
MB
Agren
B N
BN
D000327:Adsorption; D004209:Disposable Equipment; D005663:Furans / Q000737:chemistry; D008239:Lysine / Q000031:analogs & derivatives / Q000737:chemistry; D008422:Materials Testing; D009943:Organophosphorus Compounds / Q000737:chemistry; D015609:Organotechnetium Compounds / Q000737:chemistry; D010969:Plastics / Q000737:chemistry*; D019275:Radiopharmaceuticals / Q000737:chemistry*; D013670:Sodium Pertechnetate Tc 99m / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000737:chemistry; D013499:Surface Properties; D013594:Syringes; D017556:Technetium Compounds / Q000737:chemistry*; D013668:Technetium Tc 99m Aggregated Albumin / Q000737:chemistry; D019783:Technetium Tc 99m Dimercaptosuccinic Acid / Q000737:chemistry; D013669:Technetium Tc 99m Medronate / Q000031:analogs & derivatives / Q000737:chemistry; D017256:Technetium Tc 99m Sestamibi / Q000737:chemistry; D013997:Time Factors
D005663:Furans; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D010969:Plastics; D019275:Radiopharmaceuticals; D013438:Sulfhydryl Compounds; D017556:Technetium Compounds; D013668:Technetium Tc 99m Aggregated Albumin; C107877:technetium Tc 99m MAG3-biocytin; C078496:technetium Tc 99m Q12; C082426:technetium Tc99m-mercaptoacetyl albumin; C078700:technetium tc-99m tetrofosmin; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; C024226:technetium Tc 99m hydroxymethylene diphosphonate; D017256:Technetium Tc 99m Sestamibi; D013670:Sodium Pertechnetate Tc 99m; D008239:Lysine; D013669:Technetium Tc 99m Medronate