Odontogenic fibroma in Sprague-Dawley rats: a report of 2 cases.
Two cases of odontogenic fibroma occurring in aged Sprague-Dawley rats are described. Both neoplasms were associated with a maxillary incisor and had identical histomorphological features. They were composed of solid proliferations of primitive, dental pulp-like mesenchyme separated by areas of collagenization. Small strands and islands of mainly undifferentiated odontogenic epithelium immunostaining for keratins were scattered throughout both tumours. As a further characteristic, the lesions contained small foci of mineralization which were either cementum-like or resembled dysplastic dentin. The odontogenic fibroma represents a further type of odontogenic tumour in rats, which due to its typical histomorphology, can easily be differentiated from other odontogenic tumours such as ameloblastic odontoma or ameloblastoma.
Ernst
H
H
Fraunhofer Institute of Toxicology and Aerosol Research, Hannover, Germany.
Scampini
G
G
Durchfeld-Meyer
B
B
Brander-Weber
P
P
Rittinghausen
S
S
D000564:Ameloblastoma / Q000473:pathology; D000818:Animals; D003937:Diagnosis, Differential; D005260:Female; D005350:Fibroma / Q000473:pathology*; D007180:Incisor / Q000473:pathology; D009808:Odontogenic Tumors / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley