A more versatile and reliable method for renal transplantation in the rat.
This study describes the authors' experience with a new method of orthotopic renal transplantation in the rat. This technique combines previously described modifications with the use of the donor inferior vena cava as a conduit to perform an end-to-side venous anastomosis. Survival was 87% and 80% at 3 and 120 days, respectively. Patency was 80% at 120 days, and histologic examination revealed normal renal architecture and parenchyma, with no evidence of ischemic injury. This technique offers a refinement of previous techniques and is reliable, flexible, and can be easily learned by novice microvascular surgeons.
Blom
D
D
Department of Surgery, University of Rochester School of Medicine and Dentistry, NY 14642, USA.
Orloff
M S
MS
D000714:Anastomosis, Surgical; D000818:Animals; D007668:Kidney / Q000033:anatomy & histology; D016030:Kidney Transplantation / Q000379:methods*; D008297:Male; D008866:Microsurgery / Q000379:methods; D051381:Rats; D011916:Rats, Inbred F344; D011917:Rats, Inbred Lew; D014184:Transplantation, Homologous; D014654:Vascular Patency; D014682:Vena Cava, Inferior / Q000637:transplantation