Schistosoma mansoni infection in owl monkeys (Aontus nancymai): evidence for the early elimination of adult worms.
Detailed parasitologic, serologic, clinical and histopathologic studies were conducted in owl monkeys (Aotus nancymai) exposed to varying numbers of cercariae of Schistosoma mansoni. All the experimental animals had clinical symptoms suggestive of infection (weight loss diarrhoea, mucus in stools, etc.) which were not seen in uninfected individuals. The only A. vociferans included in this study passed S. mansoni eggs 8 weeks after infection. None of the A. nancymai passed eggs in their faeces. No adult worms were recovered following perfusion of the sacrificed experimental monkeys, suggesting that they were early eliminated. Serological techniques (ELISA-SEA and COPT) allowed diagnosis of infection, starting 9 weeks post challenge, in all but one A. nancymai exposed to 100 cercariae. Granulomas containing eggs were observed predominantly in liver and less extensively in intestine, suggesting that adult worms were mainly lodged in the intrahepatic portal system. We conclude that A. nancymai is susceptible to infection with S. mansoi, with the worms reaching sexual maturity, but being eliminated shortly after oviposition.
Noya
O
O
Instituto de Medicina Tropical, Universidad Central de Venezuela, Caracas.
Gonzalez-Rico
S
S
Rodriguez
R
R
Arrechedera
H
H
Patarroyo
M E
ME
Alarcon de Noya
B
B
D000818:Animals; D016645:Aotidae / Q000469:parasitology* / Q000502:physiology; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005243:Feces / Q000469:parasitology; D006099:Granuloma / Q000276:immunology / Q000469:parasitology / Q000662:veterinary; D006400:Hematocrit / Q000662:veterinary; D006454:Hemoglobins / Q000032:analysis; D007422:Intestines / Q000469:parasitology / Q000473:pathology; D007958:Leukocyte Count / Q000662:veterinary; D008099:Liver / Q000469:parasitology / Q000473:pathology; D008168:Lung / Q000469:parasitology / Q000473:pathology; D008297:Male; D008992:Monkey Diseases / Q000276:immunology* / Q000469:parasitology; D010270:Parasite Egg Count / Q000662:veterinary; D011223:Praziquantel / Q000627:therapeutic use; D011233:Precipitin Tests / Q000662:veterinary; D012550:Schistosoma mansoni / Q000276:immunology* / Q000502:physiology; D012555:Schistosomiasis mansoni / Q000276:immunology / Q000469:parasitology / Q000662:veterinary*; D012556:Schistosomicides / Q000627:therapeutic use; D012908:Snails
D006454:Hemoglobins; D012556:Schistosomicides; D011223:Praziquantel