[Ethanol-induced injury and GI bleeding].
Ethanol-induced injury of digestive organs closely linked to the GI bleeding. The gastric or esophageal mucosal hemorrhage evoked by extra-amounts of alcohols is initiated by the microcirculatory damage of gastrointestinal mucosa. Many investigators focused on the ethanol-induced gastric ulcer formation as well as the ethanol-induced gastroesophageal reflux injury. Although the most important treatment for such a damage is of course to stop the drinking, it is also important to protect the gastrointestinal mucosa by potentiate the mucosal defense systems.
Department of Internal Medicine, School of Medicine, Keio University.
H
H
Suzuki
M
M
Kajiwara
S
S
Miura
H
H
Ishii
D000434:Alcoholic Beverages / Q000009:adverse effects*; D000818:Animals; D000431:Ethanol / Q000009:adverse effects*; D005609:Free Radicals; D005753:Gastric Mucosa / Q000098:blood supply; D005764:Gastroesophageal Reflux / Q000139:chemically induced; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced*; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D007511:Ischemia / Q000150:complications; D008833:Microcirculation; D018384:Oxidative Stress
D005609:Free Radicals; D000431:Ethanol; D005978:Glutathione