The role of N-methyl-D-aspartate receptor in the guinea pig inner ear after unilateral labyrinthectomy.
To investigate the role of the N-methyl-D-aspartate (NMDA) receptor in the vestibular periphery, vestibular compensation in the guinea pig was studied following chemical unilateral labyrinthectomy by osmotic pump administration of streptomycin sulfate (SM) with or without D-2-amino-5-phosphonovalerate (D-APV), one of the NMDA receptor antagonists. All animals administrated SM (SM group) or SM and D-APV (SM + D-APV group) showed spontaneous nystagmus and head tilt. The maximum degree of yaw head tilt in the SM + D-APV group was statistically smaller than that in the SM group. Moreover the time constant for head tilt in the SM + D-APV group was statistically shorter than that in the SM group. These results indicate that the NMDA receptor in the vestibular periphery influences vestibular compensation after unilateral labyrinthectomy.
Shimogori
H
H
Department of Otolaryngology, Yamaguchi University School of Medicine, Ube-City, Japan. shimo-h@po.cc.yamaguchi-u.ac.jp
Yamashita
H
H
Takahashi
M
M
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents; D007758:Ear, Inner / Q000737:chemistry* / Q000187:drug effects / Q000601:surgery*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D006168:Guinea Pigs; D008297:Male; D009759:Nystagmus, Pathologic / Q000503:physiopathology; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000502:physiology*; D013307:Streptomycin; D014725:Vestibular Nerve / Q000502:physiology; D014882:Water-Electrolyte Balance / Q000502:physiology
D000900:Anti-Bacterial Agents; D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D015763:2-Amino-5-phosphonovalerate; D013307:Streptomycin