[Procalcitonin in severe trauma].
The diagnosis of infection in systemic inflammatory syndrome response is difficult but essential for correct patient management. Procalcitonin is a new biochemical marker of infection especially for bacterial infection. Procalcitonin and C-reactive protein (CRP) were prospectively studied in 21 severe trauma patients and correlated with the trauma severity and the occurrence of infection. At the early post-traumatic period (admission to day 3) procalcitonin and CRP are correlated with the severity of trauma (early volume loading and markers of tissue injury) as did typically acute inflammatory proteins. At the late post-traumatic period (day 7) while CRP concentrations remain elevated in all patients, procalcitonin concentrations are only raised in septic patients even if inflammation's clinical signs persist.
Service de biochimie-hormonologie, Hôpital Robert-Debré, Paris.
J F
JF
Benoist
O
O
Mimoz
M
M
Assicot
D000293:Adolescent; D000328:Adult; D001424:Bacterial Infections / Q000097:blood / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011498:Protein Precursors / Q000097:blood*; D012720:Severity of Illness Index; D014947:Wounds and Injuries / Q000097:blood* / Q000150:complications / Q000382:microbiology*
D015415:Biomarkers; C000606589:CALCA protein, human; D011498:Protein Precursors; D002116:Calcitonin; D002097:C-Reactive Protein; D015740:Calcitonin Gene-Related Peptide
La procalcitonine dans les traumatismes sévères.