[The long-term use of corticosteroid inhalations in bronchial asthma patients].
Our objective in this study was to observe how prolonged exposure to high doses of inhalation and peroral corticosteroids impacted on the risk of development of posterior subcapsular cataract (PSC). Of the 48 examinees, 27 percent revealed PSC. The presence of PSC correlated with diurnal dose of prednisone as well as with duration of its administration but no correlation was found between PSC and inhalation corticosteroids. The data obtained suggest to us that inhalation corticosteroids in hormone-dependent patients with bronchial asthma reduce the risk of PSC development.
Markov
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AE
D000280:Administration, Inhalation; D000284:Administration, Oral; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage* / Q000009:adverse effects; D000368:Aged; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001249:Asthma / Q000150:complications / Q000188:drug therapy*; D002386:Cataract / Q000139:chemically induced / Q000453:epidemiology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013997:Time Factors
D000305:Adrenal Cortex Hormones; D018927:Anti-Asthmatic Agents
Dlitel'noe primenenie ingaliatsiĭ kortikosteroidov u bol'nykh bronkhial'noĭ astmoĭ.