Magnetic resonance angiography with gadomer-17. An animal study original investigation.
OBJECTIVE
Our purpose was to investigate a "blood pool" contrast agent for abdominal and thoracic MR angiography by comparison with standard ionic and nonionic gadolinium-based contrast agents, which redistribute into the extracellular fluid compartment.


METHODS
Abdominal and thoracic MR angiography was performed in three adult dogs using a three-dimensional spoiled gradient echo pulse sequence before and after intravenous administration of one of three gadolinium-based contrast agents (gadopentetate dimeglumine, gadobutrol, and gadomer-17). Each compound was tested at five different doses in all three dogs. Quantitative analysis of signal-to-noise ratio (SNR) was performed in the aorta, inferior vena cava (IVC), liver, spleen, kidney (medulla and cortex), fat, and muscle.


RESULTS
Gadomer-17 improved visualization of vascular anatomy at doses of 0.025, 0.05, 0.1, and 0.2 mmol/kg with three-fold greater aorta SNR during the arterial phase and more than four-fold greater aorta and IVC SNR during the equilibrium phase, in comparison with gadopentetate dimeglumine and gadobutrol at equal doses.


CONCLUSIONS
Gadomer-17 is a promising contrast agent for both arterial phase and equilibrium phase MR angiography.
Dong
Q
Q
Department of Radiology, University of Michigan, Ann Arbor 48109-0030, USA. bingch@umich.edu
Hurst
D R
DR
Weinmann
H J
HJ
Chenevert
T L
TL
Londy
F J
FJ
Prince
M R
MR
D000273:Adipose Tissue / Q000098:blood supply; D000818:Animals; D001011:Aorta / Q000033:anatomy & histology; D001808:Blood Vessels / Q000033:anatomy & histology*; D003287:Contrast Media / Q000008:administration & dosage*; D004285:Dogs; D005260:Female; D005500:Follow-Up Studies; D005682:Gadolinium / Q000008:administration & dosage; D019786:Gadolinium DTPA / Q000008:administration & dosage; D007089:Image Enhancement; D007262:Infusions, Intravenous; D007668:Kidney / Q000098:blood supply; D008099:Liver / Q000098:blood supply; D018810:Magnetic Resonance Angiography / Q000379:methods; D018482:Muscle, Skeletal / Q000098:blood supply; D009942:Organometallic Compounds / Q000008:administration & dosage; D012680:Sensitivity and Specificity; D014682:Vena Cava, Inferior / Q000033:anatomy & histology
D003287:Contrast Media; D009942:Organometallic Compounds; C090600:gadobutrol; D005682:Gadolinium; D019786:Gadolinium DTPA