[Neutrophil-endothelial cell interactions in gastrointestinal diseases].
The adherence of neutrophils to the endothelium is a crucial early event in the inflammatory and immunological reaction. Neutrophil-endothelial cell interactions are known to be mediated by adhesion molecules that are expressed on each cell. Among the adhesion molecules expressed on leukocytes, the CD11/CD18 integrin family plays a major role in the adhesion and transendothelial migration of neutrophils. The two most extensively characterized endothelial cell adhesion molecules are intercellular adhesion molecule-1 and E-selectin. These adhesion molecules are involved in the pathogenesis of several digestive diseases such as Helicobacter pylori, non steroidal anti inflammatory drug- or stress-induced gastric mucosal injury, inflammatory bowel diseases.
First Department of Internal Medicine, Kyoto Prefectural University of Medicine.
T
T
Yoshikawa
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Yoshida
N
N
Sugimoto
M
M
Kondo
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D015815:Cell Adhesion Molecules / Q000502:physiology; D002450:Cell Communication; D004730:Endothelium, Vascular / Q000166:cytology / Q000502:physiology*; D005756:Gastritis / Q000382:microbiology; D005767:Gastrointestinal Diseases / Q000209:etiology*; D016481:Helicobacter Infections; D016480:Helicobacter pylori; D006801:Humans; D009504:Neutrophils / Q000502:physiology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D015815:Cell Adhesion Molecules