Functional imaging of the brain by infrared radiation (thermoencephaloscopy).
A technique for thermal imaging of the animal and human brain cortex using an infrared optical system is described. Thermoencephaloscopy (TES) is based on improved thermovision and image processing techniques and allows two-dimensional, contact-free, dynamic and non-invasive recording of background and evoked cortical activity through an unopened skull. Activated (heated) and deactivated (cooled) zones of the cerebral cortex are revealed. The instrumental temporal resolution of TES is 40 msec (25 maps sec-1), the spatial resolution is up to 70 x 70 microns pixel-1. The diameter of the smallest recordable active region of the cortex is 200-300 microns. TES allows to detect the position, size and sequence of activation of precisely located specific cortical zones, and to measure their dynamics before, during and after sensory and direct cortical stimulation, motor acts and conditioning (associative learning). TES effects were recorded in rats, rabbits, cats, monkeys and humans. Waves were found spreading over the cortex with a speed up to 33 mm sec-1 along trajectories specific for the sensory modality and the site of stimulation. Some pathological processes in the brain are detectable by TES: spreading depression; stress; catalepsy; experimental tumors; and epileptic focuses. The main mechanisms of thermal responses recorded by TES are discussed: neural activity; local metabolism of units; local cerebral blood flow; and thermoconductivity in the activated zones of the cortex. Thermoencephaloscopy is a dynamic, non-invasive, contact-free, comparatively cheap, simple and inexpensive method of neuroimaging with a relatively high temporal and spatial resolution and sensitivity. It can be a useful tool in basic neuroscience and medicine.
Department of Sensory Physiology, Institute of Higher Nervous Activity and Neurophysiology, Moscow, Russia.
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Shevelev
D000818:Animals; D001245:Association Learning / Q000502:physiology; D001831:Body Temperature / Q000502:physiology; D001931:Brain Mapping / Q000379:methods; D002540:Cerebral Cortex / Q000502:physiology*; D006801:Humans; D007259:Infrared Rays; D009043:Motor Activity / Q000502:physiology; D012677:Sensation / Q000502:physiology; D013817:Thermography / Q000379:methods*