HLA DR and AB surface antigens correlate with cell shape (surface area).
In order to help explain some of the various phenomena associated with both benign and malignant cells, this study was undertaken to determine if changes in the shape of the cell could alter the recognition of the cell. Non-transformed Human cells, HEL 299, were evaluated for their shape and surface antigens. A direct statistical correlation was found between the two surface antigens HLA AB and DR and the cell shape (surface area). The possible significance of this phenomena in non transformed human cells to neoplastic proliferation is suggested.
Department of Pathology and Laboratory Medicine, UMD-New Jersey Medical School, Newark 07103, USA.
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Ende
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AB
Ritter
D000818:Animals; D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000378:metabolism; D002460:Cell Line; D048429:Cell Size / Q000502:physiology*; D019084:Fluorescent Antibody Technique, Indirect; D015234:HLA-A Antigens / Q000378:metabolism*; D015235:HLA-B Antigens / Q000378:metabolism*; D006684:HLA-DR Antigens / Q000378:metabolism*; D006801:Humans; D008168:Lung / Q000166:cytology* / Q000378:metabolism; D051379:Mice
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens