Imedeen in the treatment of photoaged skin: an efficacy and safety trial over 12 months.
BACKGROUND
UV-exposure induces photoaging of the skin.


OBJECTIVE
Testing the efficacy and safety of oral Imedeen in photoaged skin.


METHODS
Three month placebo-controlled randomized study of 144 subjects and 9-month-uncontrolled continuation. Efficacy measurements included clinical evaluation, self-evaluation, photograph evaluation, as well as ultrasound, transepidermal water loss and replica measurements.


RESULTS
After 3 months, no significant effects were detected. One years treatment gave significant improvement compared with baseline in investigator's evaluation of fine lines and overall photoaging, in photograph evaluation of fine lines, overall photoaging, telangiectasia and hyperpigmentation, in self-evaluation of skin condition, density measurements by ultrasound, trans-epidermal water loss and skin smoothness from analysis of skin replica. No serious side-effects related to treatment were reported.


CONCLUSIONS
Imedeen appears effective and safe for treatment of photoaged skin.
Dermatology Clinic, Geels Plads 20, Virum, Denmark.
M E
ME
Kieffer
J
J
Efsen
D000152:Acne Vulgaris / Q000139:chemically induced; D000328:Adult; D012628:Dermatitis, Seborrheic / Q000139:chemically induced; D004311:Double-Blind Method; D004487:Edema / Q000139:chemically induced; D005500:Follow-Up Studies; D006025:Glycosaminoglycans / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D008875:Middle Aged; D010352:Patient Dropouts; D011506:Proteins / Q000008:administration & dosage* / Q000009:adverse effects; D012867:Skin / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology; D015595:Skin Aging / Q000187:drug effects* / Q000473:pathology; D016896:Treatment Outcome; D014463:Ultrasonography; D014870:Water Loss, Insensible / Q000187:drug effects; D015430:Weight Gain / Q000187:drug effects
D006025:Glycosaminoglycans; C070172:Imedeen; D011506:Proteins