Genomic structure of a novel human gene (XYLB) on chromosome 3p22-->p21.3 encoding a xylulokinase-like protein.
We isolated a novel human cDNA of 1963 nucleotides that included an open reading frame encoding a protein of 528 amino acids. Homology analysis indicated that the predicted gene product, XYLB, bore 22% identity to the xylulokinase of Haemophilus influenzae that plays an important role in energy metabolism. The gene consists of 18 exons and spans about 28 kb of genomic DNA on chromosome 3p21.3.
Laboratory of Molecular Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
M
M
Tamari
Y
Y
Daigo
S
S
Ishikawa
Y
Y
Nakamura
D015152:Blotting, Northern; D002893:Chromosomes, Human, Pair 3; D003001:Cloning, Molecular; D003360:Cosmids; D018076:DNA, Complementary / Q000235:genetics; D005091:Exons; D015894:Genome, Human; D006801:Humans; D007438:Introns; D008969:Molecular Sequence Data; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000235:genetics*; D012326:RNA Splicing; D012333:RNA, Messenger / Q000032:analysis; D017386:Sequence Homology, Amino Acid
D018076:DNA, Complementary; D012333:RNA, Messenger; D017853:Phosphotransferases (Alcohol Group Acceptor); C032700:xylulokinase