Efficacy of surgical and/or podophyllotoxin treatment against flat acetowhite penile human papillomavirus associated lesions.
In order to investigate the efficacy of treatment modalities favoured by us against flat acetowhite penile human papillomavirus (HPV)-induced lesions, we studied retrospectively standardized medical records of 81 men who had been treated for this condition. The patients were treated surgically with diathermy (n=32) or with a combination of both chemical (topical application of podophyllotoxin) and surgical treatment (n=49). The mean number of clinic visits was 9.1 (range 1-19), during a follow-up time of mean 30.9 (range 1-104) months for 78 of the men, 3 of them only visited the clinic once. The mean time for cure was 19.9 (range 0-103) months. Only 12 (15%) patients were healed after one single treatment session, while as many as 50 (62%) required > 4 sessions. The mean number of surgical treatment sessions required for cure differed significantly (P=0.0006) between the previously treated patients who needed a mean of 5.6 treatment sessions, compared to the previously untreated men who required surgery a mean of 3.4 times for cure.
Department of Dermatovenereology, Karolinska Hospital, Stockholm, Sweden.
A
A
Wikström
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G
von Krogh
D019342:Acetic Acid; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D003218:Condylomata Acuminata / Q000628:therapy; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D010409:Penile Diseases / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000821:virology*; D011034:Podophyllotoxin / Q000627:therapeutic use*; D014412:Tumor Virus Infections / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000628:therapy*
D000998:Antiviral Agents; D011034:Podophyllotoxin; D019342:Acetic Acid