The cholinergic deficit in Alzheimer's disease.
The history of the discovery of cholinergic deficit in Alzheimer's disease is briefly reviewed, focusing on the cholinergic basal forebrain. The anatomy of the structure is discussed, and the clinical implications of pathology in this population of nerve cells are presented.
Whitehouse
P J
PJ
Department of Behavioral and Geriatric Neurology, Case Western Reserve University, University Alzheimer Center, Cleveland, Ohio 44120-5000, USA.
D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology; D001479:Basal Ganglia / Q000033:anatomy & histology / Q000503:physiopathology; D002452:Cell Count; D048429:Cell Size; D002795:Choline O-Acetyltransferase / Q000172:deficiency / Q000378:metabolism; D018678:Cholinergic Agents / Q000627:therapeutic use; D002799:Cholinergic Fibers / Q000473:pathology; D006801:Humans; D011950:Receptors, Cholinergic / Q000502:physiology; D013377:Substantia Innominata / Q000033:anatomy & histology / Q000473:pathology* / Q000503:physiopathology
D018678:Cholinergic Agents; D011950:Receptors, Cholinergic; D002795:Choline O-Acetyltransferase