Intestinal fat suppressed intake of fat longer than intestinal sucrose.
Although animals eventually stop eating when only experiencing the oro-sensory stimuli from a food, they stop eating much more rapidly if they also receive postgastric stimuli simultaneously. This suggests that the postgastric effects of a nutrient influence the hedonic value of food or motivation to consume that food, and thus, can influence food selection within the time frame of a meal. In this experiment, rats were equipped with a gastric fistula and duodenal cannula. This combination allowed them to receive the same oro-sensory stimuli, but different postgastric nutrients. While ingesting either a fat (Intralipid) or carbohydrate (sucrose) solution, both of which drained from the gastric fistula, the rats received a duodenal infusion of either sucrose (10 mLs, 0.24 kcals/mL), fat (10 mLs, 0.25 kcals/mL) or saline (10 mLs, 0 kcals/mL). While ingesting the Intralipid, a duodenal infusion of fat suppressed intake quicker and longer than an infusion of sucrose. While the animals ingested sucrose, sucrose and fat suppressed intake equivalently.
Foster
L A
LA
Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan 66506, USA. foster@vet.ksu.edu
Boeshore
K
K
Norgren
R
R
D000818:Animals; D003864:Depression, Chemical; D004041:Dietary Fats / Q000378:metabolism / Q000494:pharmacology*; D019422:Dietary Sucrose / Q000378:metabolism / Q000494:pharmacology*; D004386:Duodenum / Q000378:metabolism; D005247:Feeding Behavior / Q000187:drug effects*; D005753:Gastric Mucosa / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism*; D007441:Intubation, Gastrointestinal; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013270:Stomach / Q000502:physiology; D013997:Time Factors
D004041:Dietary Fats; D019422:Dietary Sucrose