Medication bezoars: a literature review and report of a case.
OBJECTIVE
To describe a case of a medication bezoar and to review the clinical presentation, diagnosis, risk factors, pathogenesis, complications, and treatment of medication bezoars.


METHODS
A MEDLINE search (January 1966-December 1997) of the English-language literature pertaining to bezoars was performed. These articles were scanned, and literature specifically discussing medication bezoars was selected. Additionally, the reference sections of pertinent review and case reports were scanned for additional relevant literature.


RESULTS
Bezoars are concretions of foreign material within the body. In the case of medication bezoars, these concretions occur within the digestive tract and are composed of medications and/or medication vehicles. Rarely, however, is bezoar formation solely due to a medication. In nearly all reported cases the patient had one or more significant risk factors that contributed to bezoar formation. The exact method by which medications bezoars form is dependent on the particular type or combination of medications involved. Bezoar formation may be associated with significant complications for the patient due to the presence of the bezoar and because of the effects of the medication within the bezoar. Treatment of medication bezoars depends largely on the location and the cause of the bezoar.


CONCLUSIONS
Medication bezoars are a rare but potentially serious complication of medication use in certain patients. These patients often present with signs and symptoms consistent with an obstruction of the gastrointestinal tract and represent an even greater diagnostic challenge due to the rarity of this complication. These patients also face significant complications from both the bezoar and the medication within the bezoar. To date, treatment of medication bezoars involves mainly physical manipulation of the bezoar through lavage, endoscopic removal, or, in most cases, surgical removal.
Department of Pharmacy Practice, University of Florida, Gainesville, USA.
J R
JR
Taylor
D S
DS
Streetman
S S
SS
Castle
D000368:Aged; D001630:Bezoars / Q000139:chemically induced* / Q000628:therapy*; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D008297:Male; D009543:Nifedipine / Q000009:adverse effects; D012307:Risk Factors; D014665:Vasodilator Agents / Q000009:adverse effects
D014665:Vasodilator Agents; D009543:Nifedipine