Hairy cell leukemia. What is new forty years after the first description?
Hairy cell leukemia represent 2% of all the leukemias. The etiology is unknown. The diagnosis is based on the peripheral blood examination, showing characteristic lymphoid B cells, with loose lacy chromatin and unconstant cytoplasmic projections. The abnormal lymphoid cells express CD19, CD20, CD22, CD79a, CD25 and CD103. The tumor cells are Sig + with clonal light chain restriction. The treatment is based on recombinant IFN: we discuss the interest and the risks of second malignancy related to the prescription of the purine analogues.
Laboratoire d'Hématologie, CHU Côte de Nacre, Caen, France.
X
X
Troussard
F
F
Maloisel
G
G
Flandrin
D015762:2-Chloroadenosine / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use; D015703:Antigens, CD / Q000032:analysis; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001402:B-Lymphocytes / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology; D002986:Clinical Trials as Topic; D003839:Deoxyadenosines / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007155:Immunologic Factors / Q000009:adverse effects / Q000627:therapeutic use; D007370:Interferon Type I / Q000009:adverse effects / Q000627:therapeutic use; D007943:Leukemia, Hairy Cell / Q000188:drug therapy / Q000473:pathology / Q000628:therapy; D009363:Neoplasm Proteins / Q000032:analysis; D016609:Neoplasms, Second Primary / Q000139:chemically induced; D014411:Neoplastic Stem Cells / Q000473:pathology; D015649:Pentostatin / Q000009:adverse effects / Q000627:therapeutic use; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis; D011994:Recombinant Proteins; D013156:Splenectomy; D014740:Vidarabine / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use
D015703:Antigens, CD; D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D003839:Deoxyadenosines; D007155:Immunologic Factors; D007370:Interferon Type I; D009363:Neoplasm Proteins; D016692:Receptors, Antigen, T-Cell, gamma-delta; D011994:Recombinant Proteins; D015762:2-Chloroadenosine; D015649:Pentostatin; D014740:Vidarabine; C055994:2-chloro-3'-deoxyadenosine; C024352:fludarabine