[Prognostic factors in operable epidermoid esophageal cancers].
OBJECTIVE
The aims of the study were to determine the prognostic factors on overall survival in patients with resectable squamous cell esophageal carcinoma.


METHODS
Two hundred and ninety three patients with stage I and II tumor were included in a phase III clinical trial that compared surgery alone to preoperative chemoirradiation. Eighteen parameters issued from clinical, biological radiological and pathological characteristics were included in univariate and multivariate analysis.


RESULTS
The overall survival was influenced by: quality of surgical resection tumor response, nodal involvement on the CT-scan, tumor length and tumor location. Three groups of patients could be identified on two simple clinical preoperative variables. The first group: patients without dysphagia with or without nodal involvement on the CT-scan. The second group: patients with dysphagia and without nodal involvement on the CT-scan. The third group: patients with dysphagia and with nodal involvement with CT-scan. The 5 years survival rates were 34% for the first group, 23% for the second group and 0% for the third group.


CONCLUSIONS
The identification of prognostic factors is valuable for the stratification of patients in future therapeutic studies.
Woronoff
A S
AS
Unité de Recherche en Cancérologie Digestive, Hôpital Universitaire, Besançon.
Mercier
M
M
Gignoux
M
M
Triboulet
J P
JP
Chaillard
G
G
Bosset
J F
JF
D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D003680:Deglutition Disorders; D004938:Esophageal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate; D014057:Tomography, X-Ray Computed
Facteurs pronostiques des cancers épidermoïdes de l'oesophage opérables.