Localized amyloidosis of the uterine cervix.
Localized amyloidosis of the uterine cervix is a rare entity. Only seven cases have been reported to date, and all were associated with a primary cervical squamous cell carcinoma; immunohistochemical studies proved the amyloid to be composed of cytokeratin, presumably derived from degenerated tumor cells. We report localized cervical amyloidosis producing a 1-cm nodule in a 28-year-old woman in the absence of systemic amyloidosis or a squamous cell carcinoma. Immunohistochemical stains showed the amyloid to be composed of amyloid-associated protein, a protein produced in chronic inflammatory conditions.
Gibbons
D
D
Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235-9073, USA.
Lindberg
G M
GM
Ashfaq
R
R
Saboorian
M H
MH
D000328:Adult; D000682:Amyloid / Q000032:analysis; D000686:Amyloidosis / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D007146:Immunoglobulin lambda-Chains / Q000032:analysis; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D002577:Uterine Cervical Diseases / Q000175:diagnosis* / Q000473:pathology
D000682:Amyloid; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains; D007633:Keratins