From trial data to practical knowledge: qualitative study of how general practitioners have accessed and used evidence about statin drugs in their management of hypercholesterolaemia.
OBJECTIVE
To explore how general practitioners have accessed and evaluated evidence from trials on the use of statin lipid lowering drugs and incorporated this evidence into their practice. To draw out the practical implications of this study for strategies to integrate clinical evidence into general medical practice.


METHODS
Qualitative analysis of semistructured interviews.


METHODS
General practices in Lothian.


METHODS
24 general practitioners selected to obtain a heterogeneous sample.


RESULTS
Respondents were generally aware of the evidence relating to the use of statins in secondary prevention of coronary heart disease, but they were less clear about the evidence in primary prevention. The benefits of statins in secondary prevention were clearer to them and the social and economic issues less complex than was the case for use in primary prevention. Respondents rarely said they appraised the methods and content of trials, rather they judged the trustworthiness of the source of trial evidence and interpreted it within the context of the economic and social factors which impinge on their practice. Moreover, trial data become relevant for routine practice only when underpinned by a consensus on these issues.


CONCLUSIONS
Strategies to promote incorporation of evidence from clinical trials into everyday practice are likely to be effective if they tap into and build on the process of local consensus building. Strategies such as teaching critical appraisal skills and guideline development may have little effect if they are separated from this process.
Fairhurst
K
K
Department of Community Health Sciences (General Practice), University of Edinburgh, Levinson House, Edinburgh EH8 9DX. Karen.Fairhurst@ed.ac.uk
Huby
G
G
D000368:Aged; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D002983:Clinical Competence; D002986:Clinical Trials as Topic; D003657:Decision Making; D019317:Evidence-Based Medicine; D005194:Family Practice; D019983:Guideline Adherence; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy*; D017410:Practice Guidelines as Topic; D012606:Scotland
D000924:Anticholesteremic Agents