Cerebrospinal fluid--physiology, analysis and interpretation of protein patterns for diagnosis of neurological diseases.
The state of the art in routine CSF analysis is reviewed with particular reference to multiple sclerosis regarding: (1) The physiology and pathophysiology of blood-CSF barrier function and dysfunction with the CSF flow rate as main modulator of blood- and brain-derived protein concentrations in CSF; (2) The neuroimmunological aspects regarding (a) patterns of disease-related immunoglobulin class response (IgG, IgA, IgM) in actual Reiber graphs with reference to specific parameters and optional tests, and (b) the oligoclonal, polyspecific antibody synthesis in brain; (3) Particular marker proteins in CSF and blood for differential diagnosis of neurological diseases; (4) Mathematical base for evaluations of CSF data with an example of a multiple sclerosis patient for calculation of intrathecal immunoglobulin and antibody synthesis as well as Antibody Index.
Neurochemisches Labor der Neurologischen Klinik, Universitat Göttingen, Germany.
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H
Reiber
D015415:Biomarkers / Q000737:chemistry; D001812:Blood-Brain Barrier / Q000502:physiology*; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis / Q000502:physiology*; D003627:Data Interpretation, Statistical; D003937:Diagnosis, Differential; D006801:Humans; D009422:Nervous System Diseases / Q000175:diagnosis*; D015213:Neuroimmunomodulation
D015415:Biomarkers; D002556:Cerebrospinal Fluid Proteins