[Study on the mitoxantrone ethylcellulose microspheres for liver artery embolization].
In this paper, orthogonal test was used to optimize the preparation conditions and technique of mitoxantrone ethylcellulose microspheres (DHAQ-EC-MS) for liver embolization. The dynamic osmosis method was used to study the drug release characteristics of DHAQ-EC-MS. DHAQ-EC-MS suspension for clinical liver artery embolization was prepared. The result showed that the DHAQ-EC-MS is regular in its morphology with a mean diameter of 110.24 +/- 38.19 microns. The drug loading was 12.5% and embedding ratio was 55.6%. The release characteristics was in accord with single exponential model. The drug release equation is lg(Yinfinity - Y) = -0.116t - 1.198 x 10(-3) (gamma = 0.9992, t50 = 2.6 h). The DHAQ-EC-MS was shown to be physically and chemically stable and its suspension is suitable for clinical use. Experiments in dogs indicate that drug concentration of DHAQ-EC-MS in hepatic vein blood was higher than DHAQ solution, and the MRT0-72 was 2.45 times higher than DHAQ solution.
School of Pharmacy, West China University of Medical Sciences, Chengdu.
Z R
ZR
Zhang
D
D
Wang
F Y
FY
Liao
G T
GT
Liao
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D016461:Chemoembolization, Therapeutic; D004285:Dogs; D005260:Female; D006499:Hepatic Artery; D008297:Male; D008863:Microspheres; D008942:Mitoxantrone / Q000008:administration & dosage* / Q000493:pharmacokinetics; D013678:Technology, Pharmaceutical
D000970:Antineoplastic Agents; D008942:Mitoxantrone