Phenotypical response in different cell types of rat uterus to centchroman. A qualitative analysis.
To assess the alleged estrogenic and antiestrogenic profile of centchroman, a phenotypical response was studied in native uterine cells or migrant blood cells in adult ovariectomized rats under the influence of estradiol-dipropionate (EDP) and centchroman (CC) given per se and together. Histologic observations were divided arbitrarily into the following regions: luminal epithelium, superficial and deep stroma, and the two layers of muscularis. Glandular cell proliferation, mitoses, and vascularity were examined additionally. It was found that CC per se stimulated luminal epithelial cell height and glandular cell proliferation better than EDP. Leukocytic infiltration and vascularity were also more pronounced in the uteri of CC-treated rats. Furthermore, except for a slight reduction in glandular cell size and edematous condition of circular muscle layer, the changes remained unaffected after conjoint treatment of CC and EDP. The observations revealed that some of the nongenomic responses, elicited by the rat uterus after CC treatment, seem to be unrelated to the hormonal attributes of the molecule.
Division of Endocrinology, Central Drug Research Institute, Lucknow, India. root@cscdri.ren.nic.in
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Mehrotra
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Srivastava
D000818:Animals; D002486:Centchroman / Q000494:pharmacology*; D003283:Contraceptives, Postcoital, Synthetic / Q000494:pharmacology*; D004717:Endometrium / Q000187:drug effects; D004847:Epithelial Cells / Q000187:drug effects; D004965:Estrogen Antagonists / Q000494:pharmacology*; D005260:Female; D010052:Ovariectomy; D010641:Phenotype; D051381:Rats; D017207:Rats, Sprague-Dawley; D014599:Uterus / Q000187:drug effects*
D003283:Contraceptives, Postcoital, Synthetic; D004965:Estrogen Antagonists; D002486:Centchroman