Optimization and mechanism of step-leap respiration exercise in treating of cor pulmonale.
The interaction between cardiovascular system and the respiratory system is complicated and may be used for the rehabilitation of the cor pulmonale disease. To study the effects of different breathing mode on the cardiac and pulmonary systems, a mathematical model is established based on the previous work. Using this model, computer simulation experiments are carried out for searching an optimal respiration mode in treating of cor pulmonale disease. Results indicate that the step-leap respiration mode could provide a better assistant to the rehabilitation of the cor pulmonale patients in the sense of increasing coronary flow, reducing pulmonary arterial pressure and reducing the working load for the right heart. This result is also proven by the clinical experiments. This work may suggest that a proper directed respiration exercise can be used in the treatment of cor pulmonale disease.
Bai
J
J
Department of Electrical Engineering, School of Life Science and Engineering, Tsinghua University, Beijing, China. deabj@mail.tsinghua.edu.cn
Lu
H
H
Zhang
J
J
Zhao
B
B
Zhou
X
X
D000465:Algorithms; D016280:Atrial Function, Right / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D001945:Breathing Exercises; D003198:Computer Simulation; D003326:Coronary Circulation / Q000502:physiology; D006321:Heart / Q000503:physiopathology; D006801:Humans; D008168:Lung / Q000503:physiopathology; D008954:Models, Biological; D008955:Models, Cardiovascular; D011651:Pulmonary Artery / Q000503:physiopathology; D011660:Pulmonary Heart Disease / Q000534:rehabilitation*; D015203:Reproducibility of Results; D012119:Respiration; D013318:Stroke Volume / Q000502:physiology; D016278:Ventricular Function, Right / Q000502:physiology; D017725:Ventricular Pressure / Q000502:physiology