Computational methods for exon detection.
Computer methods for the complete and accurate detection of genes in vertebrate genomic sequences are still a long way to perfection. The intermediate task of identifying the coding moiety of genes (coding exons) is now reasonably well achieved using a combination of methods. After reviewing the intrinsic difficulties in interpreting vertebrate genomic sequences, this article presents the state-of-the-art, with an emphasis on similarity search methods and the resources available through Internet.
Claverie
J M
JM
jmc@igs.cnrs-mrs.fr
D000818:Animals; D001483:Base Sequence; D003205:Computing Methodologies; D017124:Conserved Sequence; D016208:Databases, Factual; D005060:Europe; D005091:Exons; D005796:Genes; D006801:Humans; D020407:Internet; D007564:Japan; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D014481:United States; D014584:User-Computer Interface; D014714:Vertebrates / Q000235:genetics