[What uses for the acellular pertussis vaccine?].
The acellular pertussis vaccine offers a better tolerance as compared with the whole cell pertussis vaccine. It has also a good protective effect against whooping cough. However given as a combined pentavalent vaccine for the primary immunization of infants, it appears to introduce an immune interference leading to a diminished response to the Haemophilus type b or poliomyelitis valence according to the type of vaccine. Thus it is recommended that immunization against whooping cough in France in the coming years uses whole cell pertussis combined vaccine for the primary immunization of infants at 2, 3 and 4 months, the acellular pertussis vaccine being used for the booster injections at 18 months and 10-11 years.
Hôpital d'enfants Armand-Trousseau, Paris, France.
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Grimprel
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Bégué
D002648:Child; D002675:Child, Preschool; D000075202:Contraindications; D005602:France; D006801:Humans; D007223:Infant; D010567:Pertussis Vaccine / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D014611:Vaccination / Q000592:standards; D017778:Vaccines, Combined
D010567:Pertussis Vaccine; D017778:Vaccines, Combined
Quelles utilisations pour les vaccins coquelucheux acellulaires?