In vitro activities of ampicillin-sulbactam and amoxicillin-clavulanic acid against Acinetobacter baumannii.
In vitro susceptibility patterns of newer beta-lactamase-inhibiting antibiotics ampicillin-sulbactam (A/S) and amoxicillin-clavulanic acid (A/C) for 100 consecutive isolates of Acinetobacter baumannii obtained from various clinical samples were studied. The A/C MIC for 86% of the strains was more than 16/8 microgram/ml, whereas there was an A/S MIC of more than 16/8 microgram/ml for only 38% of the strains. This showed that A/S has significantly superior in vitro activity compared to A/C against A. baumannii, although, theoretically, both should have similar activities. The therapeutic superiority of A/S over A/C needs to be studied, or else the breakpoints for these agents in in vitro tests need to be redefined.
Pandey
A
A
Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India 110029, USA.
Kapil
A
A
Sood
S
S
Goel
V
V
Das
B
B
Seth
P
P
D000150:Acinetobacter / Q000187:drug effects* / Q000302:isolation & purification; D000151:Acinetobacter Infections / Q000188:drug therapy / Q000382:microbiology; D000658:Amoxicillin / Q000008:administration & dosage; D000667:Ampicillin / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D019818:Clavulanic Acid / Q000008:administration & dosage; D004359:Drug Therapy, Combination / Q000008:administration & dosage*; D006801:Humans; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000008:administration & dosage*; D013407:Sulbactam / Q000008:administration & dosage; D018440:beta-Lactam Resistance
D000900:Anti-Bacterial Agents; D010406:Penicillins; D019818:Clavulanic Acid; D000667:Ampicillin; D000658:Amoxicillin; D013407:Sulbactam