[Imaging and differentiation of atherosclerotic plaque with magnetic resonance tomography].
Magnetic resonance (MR) imaging studies have allowed the imaging of an atheroma, its size, shape, and lipid contents. The aim of our study was to characterize atherosclerotic lesions using a 0.5 T magnet, to delineate plaque components, and to compare MR results with histology. Thirty necropsy specimens of human iliac arteries were studied. Magnetic resonance imaging studies were carried out on a 0.5 Tesla superconducting magnet using a 5 cm surface coil. The position for the coronal MR planes was oriented by an external marker. The matrix size was 256 x 256, 4 NEX, and the FOV was 45 mm. The pulse sequences used included SE 520/29 and SE 2200/28 and 90. Signal intensity (SI) of fibrous plaques increased significantly from 28.3 +/- 3.8 to 49.1 +/- 8.2 (p < or = 0.0001) and decreased at SE 2200/90 to 24.1 +/- 6.8 (p < or = 0.0001). However, lipid plaque components showed no significant change in SI between T1-weighted pulse-sequences (28.2 +/- 5.4) and T2-weighted pulse-sequences (25.5 +/- 5.9). Only at SE 2200/90 SI of lipid plaques decreased significantly (11.8 +/- 3.9, p < or = 0.0001). As compared to histology, MR has shown a high sensitivity and specificity in the detection of fibrous and lipid plaque components. In conclusions, our study demonstrated that MR is highly effective in the characterization of atherosclerotic lesions.
Loewe
C
C
Abt. für Kardiologie, Universität Wien.
Oberhuber
G
G
Loewe
R
R
Frank
H
H
D001161:Arteriosclerosis / Q000175:diagnosis*; D004867:Equipment Design; D006801:Humans; D007083:Iliac Artery / Q000473:pathology; D007089:Image Enhancement / Q000295:instrumentation; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D012680:Sensitivity and Specificity; D017540:Tunica Media / Q000473:pathology
Darstellung und Differenzierung atherosklerotischer Plaques mittels Magnetresonanz.