Immunogenicity of BHK-rabies vaccine in human volunteers.
The production of rabies vaccine on baby hamster kidney (BHK-21) cells for human use is discussed. Long term experience in application of this vaccine in animals, without any noticeable complications and findings of inactivation of contaminated DNA from the cell substrate by beta-propiolactone have justified its recommendation for human use. Preliminary results of applying this simple, adjuvant vaccine in volunteers, confirmed its good tolerability and immunogenicity.
Lalosević
D
D
Pasteur Institute, Novi Sad, Yugoslavia.
Stankov
S
S
Lazarević-Ivanc
L
L
Lalosević
V
V
Knezević
I
I
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D002460:Cell Line; D006224:Cricetinae; D005260:Female; D006801:Humans; D007668:Kidney; D008297:Male; D011819:Rabies Vaccines / Q000009:adverse effects / Q000276:immunology*; D011820:Rabies virus / Q000276:immunology
D000914:Antibodies, Viral; D011819:Rabies Vaccines