Successful treatment of Sjögren's syndrome with cyclophosphamide pulse therapy: report of one case.
The treatment of Sjögren's syndrome (SS) is very controversial, though several therapeutic regimens have been proposed. Cyclophosphamide pulse therapy has been widely used in many disease entities. However, reports concerning its clinical application in SS were very rare. We report a 17-year-old girl presenting with lupus nephritis and SS, which was refractory to corticosteroid therapy but successfully treated with cyclophosphamide pulse therapy. The improvement of clinical features was confirmed by Schirmer's test and minor salivary gland biopsy.
Chu
S M
SM
Department of Pediatrics, Chang Gung Children's Hospital, Taoyuan, Taiwan, R.O.C.
Huang
J L
JL
Lin
S J
SJ
Hsueh
C
C
D000293:Adolescent; D003520:Cyclophosphamide / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D008181:Lupus Nephritis / Q000150:complications; D012859:Sjogren's Syndrome / Q000150:complications / Q000188:drug therapy* / Q000473:pathology
D007166:Immunosuppressive Agents; D003520:Cyclophosphamide