Role of small intestine in caloric compensations to oil premeals in rats.
We postulated that dose-responsive satiety after oil premeals varies with the number of gut sensors stimulated by lipolytic products along intestine. These experiments in fasted rats on satiety after oil premeals were performed to 1) determine whether satiety was induced by lipolytic products but not triglycerides; 2) confirm that oil empties from the stomach at rates that vary with oil loads; 3) ascertain that increasing rates of oil entry into duodenum extend the length of gut contacted by lipolytic products; and 4) judge whether length of gut contacted correlated with dose-responsive satieties to dietary oils. 5) Using specific antagonists, we attempted to define how satiety was signalled by gut sensors. Timing and degrees of satiety did not correlate with timing and extent of gastric distensions but, rather, with the timing and extent of spread of lipolytic products along small bowel. Satiety after the highest premeal load of oil was blocked by Pluronic L-81, an inhibitor of intestinal secretion of apolipoprotein A-IV, but was unaffected by MK-329 (a specific antagonist of cholecystokinin) or by capsaicin blockade of chemosensory nerves.
Departments of Physiology and Medicine, University of California Los Angeles School of Medicine and the West Los Angeles and Sepulveda Veterans Affairs Medical Centers, Los Angeles, California 90073, USA.
J H
JH
Meyer
M
M
Hlinka
A
A
Khatibi
H E
HE
Raybould
P
P
Tso
D000704:Analysis of Variance; D000818:Animals; D002250:Carbon Radioisotopes; D002628:Chemoreceptor Cells / Q000187:drug effects / Q000502:physiology; D002766:Cholecystokinin / Q000037:antagonists & inhibitors; D003314:Corn Oil / Q000494:pharmacology*; D020109:Devazepide / Q000494:pharmacology; D004041:Dietary Fats; D004435:Eating / Q000502:physiology*; D005215:Fasting; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005936:Glucans / Q000494:pharmacology; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000502:physiology*; D008066:Lipolysis; D008297:Male; D008954:Models, Biological; D020442:Poloxamer / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012528:Satiety Response / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors; D014304:Triolein / Q000378:metabolism; D014316:Tritium
D002250:Carbon Radioisotopes; D004041:Dietary Fats; D005230:Fatty Acids, Nonesterified; D005936:Glucans; D014316:Tritium; D020442:Poloxamer; D014304:Triolein; D003314:Corn Oil; D002766:Cholecystokinin; D020109:Devazepide