Linear acetogenins from Goniothalamus donnaiensis.
Four linear acetogenins, donhepocin (1), 34-epi-donhepocin (1'), donhexocin and donbutocin, have been isolated from the roots of Goniothalamus donnaiensis. 1 and 1', isolated as an epimeric pair, contain a rare gamma-hydroxymethyl-gamma-lactone. Their structures have been established on the basis of spectral and chemical evidence.
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
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D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005233:Fatty Alcohols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D005233:Fatty Alcohols; C115312:donbutocin; C115310:donhepocin; C115311:donhexocin; D015107:4-Butyrolactone