Testosterone and progesterone level alterations in the adult rat after retinoid (retinol or retinoic acid) treatment (imprinting) in neonatal or adolescent age.
Newborn rats were treated with a single dose of vitamin A (retinol), or with three doses of retinoic acid (in the 1st, 3rd and 5th days). Serum testosterone and progesterone level was measured in the four months old male and female rats, respectively. Retinol significantly decreased both hormone levels, however retinoic acid decreased the progesterone level only. In the second part of the experiments adolescent rats (in the 6th and 7th week after birth) were treated and measured similar to the newborns. In this case retinol significantly diminished testosterone level, without influencing the progesterone level. Retinoic acid decreased testosterone level and elevated progesterone level. The results demonstrate the long lasting effects of retinoid treatments at a neonatal or adolescent age, pointing also to the differences in the direction of the effects. Considering that previously the receptorial and sexual-behavioral effects of perinatal vitamin A treatments were observed, the experiments call attention to such harmful influences of perinatal vitamin A treatments, which are not manifested in morphological alterations.
Department of Genetics, Cell- and Immunobiology, Semmelweis University of Medicine, Budapest, Hungary.
A
A
Gaál
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G
Csaba
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D005260:Female; D008297:Male; D011374:Progesterone / Q000097:blood*; D051381:Rats; D013739:Testosterone / Q000097:blood*; D014212:Tretinoin / Q000008:administration & dosage / Q000494:pharmacology*; D014801:Vitamin A / Q000008:administration & dosage / Q000494:pharmacology*
D014801:Vitamin A; D013739:Testosterone; D011374:Progesterone; D014212:Tretinoin