Short-term endocrinological results after gamma knife surgery of pituitary adenomas.
We report our preliminary results after the radiosurgical treatment of 25 secreting pituitary adenomas with a mean follow-up of 20 months (range 6-36 months). Fifteen acromegalic patients showed a decrease of 65% in mean growth hormone (GH) levels after 6 months and of 77% after 12 months. Only 3 patients (20%) are considered to be in remission (mean GH and IGF1 level into the normal range). A decrease of prolactin (PRL) was noted in 46% and 64% at 6 and 12 months after radiosurgery in 4 patients with prolactinomas. There was no case of PRL normalizaion. At present 3/4 patients have individual PRL levels slightly above the normal range. A normalization of Urinary Free Cortisol (UFC) was noticed in 4/6 (66%) patients Cushing's disease within 6-12 months. Pituitary deficiency was noticed in this series in 4/25 patients (16%) who received subtotal or total pituitary irradiation for large postoperative remnants of secreting adenomas poorly defined on magnetic resonance imaging (MRI).
Departments of Endocrinology, Hôpital de la Tiomone, Marseille, France.
I
I
Morange-Ramos
J
J
Régis
H
H
Dufour
J M
JM
Andrieu
F
F
Grisoli
P
P
Jaquet
J C
JC
Peragut
D000172:Acromegaly / Q000503:physiopathology / Q000601:surgery; D000236:Adenoma / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery*; D000328:Adult; D002648:Child; D003480:Cushing Syndrome / Q000503:physiopathology / Q000601:surgery; D004702:Endocrine Glands / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007018:Hypopituitarism / Q000209:etiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000209:etiology; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery*; D011183:Postoperative Complications; D011184:Postoperative Period; D015175:Prolactinoma / Q000503:physiopathology / Q000601:surgery; D016634:Radiosurgery / Q000009:adverse effects / Q000295:instrumentation*; D013997:Time Factors; D016896:Treatment Outcome