[Biliary reflux can be a contributory cause of esophagitis].
In recent years duodenogastric reflux has been recognised as a possible cause of oesophagitis. Alone or in combination, bile salts, trypsin, pepsin, and hydrochloric acid have all been shown to cause oesophagitis. Duodenal content in the oesophagus can be measured by means of a new fibre-optic sensor, Bilitech 2000, a device measuring the occurrence of bilirubin and yielding 24-hour readings from the distal oesophagus. Studies in which the device has been used have shown oesophageal bilirubin to be increased in patients with oesophagitis, especially in the subgroup with such complications as oesophageal stricture or ulceration, or Barrett's oesophagus. The evidence suggests that unsatisfactory response to proton pump inhibitors in reflux patients might be due to an increase in duodenal reflux, and should be treated surgically with fundoplication or biliary diversion. This may also be true of oesophagitis patients with complications, though this remains to be shown in clinical studies.
Enheten för kirurgi, Karolinska institutet vid Danderyds sjukhus, Stockholm.
J
J
Freedman
E
E
Näslund
L
L
Granström
L
L
Backman
D001471:Barrett Esophagus / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism; D001655:Bile Reflux / Q000150:complications* / Q000000981:diagnostic imaging / Q000378:metabolism; D001663:Bilirubin / Q000032:analysis; D016145:Endoscopy, Digestive System; D004942:Esophagitis, Peptic / Q000000981:diagnostic imaging / Q000209:etiology* / Q000378:metabolism; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000000981:diagnostic imaging / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D011877:Radionuclide Imaging
D001663:Bilirubin
Gallreflux kan vara bidragande orsak till esofagit.