[Effect of combination chemotherapy of low-dose CDDP. Continuous infusion of 5-FU, and intermittent CPT-11 administration for 2 advanced pancreatic cancer cases with liver metastasis].
For advanced pancreatic cancer, there is no typical chemotherapy regimen non single chemotherapeutic agent. For example, 5-FU, Doxorubicin, MMC and Epirubicin obtained only 15-24% efficacy, and general combination chemotherapy was FAM, 5-FU+CDDP and 5-FU+Leucovorin for pancreatic cancer. Generally, in pancreatic cancer cases the performance status was poor, and most could not endure the chemotherapy regimen. 5-FU continuous infusion and low-dose CDDP regimen were effective and showed fewer side effects for pancreatic cancer. Then, for 2 cases of advanced pancreatic cancer with liver metastasis, 5-FU continuous infusion + low-dose CDDP + intermittent CPT-11 administration (5-FU 500 mg/body/24 hr + CDDP 5mg x 5 days-6 courses + CPT-11 100 mg-125 mg-150 mg, bolus i.v. intermittently) was effective. Thus, this regimen could well be effective for advanced pancreatic carcinoma.
Dept. of Surgery, Shadan Tohkoh-kai Chofu Hospital.
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Kobayashi
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Yamaguchi
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary*; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D002945:Cisplatin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D000077146:Irinotecan; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology*
D000077146:Irinotecan; D002945:Cisplatin; D005472:Fluorouracil; D002166:Camptothecin