Comparison between the scintigraphic uptake and plasma clearance of 99mTc-diethylenetriaminepentacetic acid (DTPA) for the evaluation of the glomerular filtration rate in dogs.
The scintigraphically measured percentage dose uptake of 99mTc-DTPA by the kidneys and the plasma clearance of 99mTc-DTPA have been reported to correlate well with inulin clearance. These two parameters were evaluated in seven dogs with known or suspected naturally occurring renal disease and compared to simultaneously measured renal inulin clearance. Correlation between inulin clearance and the 99mTc-DTPA plasma clearance was better (p = .0016) than the correlation between the percentage DTPA uptake by the kidney. It was concluded that measurement of 99mTc-DTPA plasma clearance is a more accurate method to estimate global glomerular filtration rate (GFR) than the percentage kidney uptake.
Barthez
P Y
PY
Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis 95616, USA.
Hornof
W J
WJ
Cowgill
L D
LD
Neal
L A
LA
Mickel
P
P
D000818:Animals; D019540:Area Under Curve; D004285:Dogs; D005260:Female; D005919:Glomerular Filtration Rate / Q000662:veterinary*; D007444:Inulin / Q000493:pharmacokinetics* / Q000652:urine; D007668:Kidney / Q000000981:diagnostic imaging / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000097:blood / Q000493:pharmacokinetics*; D016284:Technetium Tc 99m Pentetate / Q000097:blood / Q000493:pharmacokinetics*
D019275:Radiopharmaceuticals; D007444:Inulin; D016284:Technetium Tc 99m Pentetate