Stat3 and NFkappaB glial expression after excitotoxic damage to the postnatal brain.
The nuclear factor-kappa B (NFkappaB) and the signal transducer activator of transcription 3 (STAT3), are putative transcription factors activated by growth factors and cytokines, and involved in glial gene expression changes after neuronal injury. Immunocytochemical analysis of NFkappaB and STAT3 from 2 h to 14 days after excitotoxic damage to the postnatal rat brain showed STAT3- and NFkappaB-positive glial cells at 2 h post-lesion, increasing in number to reach a maximum at day 1. Immunoreactivity then decreased but the glial scar remained positive. Glial STAT3 immunoreactivity was located in the nucleus up to 1 day post-lesion and in the nucleus, cytoplasm and cell processes from day 3. Glial NFkappaB immunoreactivity was mainly cytoplasmatic.
Acarin
L
L
Faculty of Medicine, Department of Cell Biology and Physiology, Autonomous University of Barcelona, Bellaterra, Spain.
González
B
B
Castellano
B
B
D000209:Acute-Phase Proteins / Q000096:biosynthesis*; D000818:Animals; D000831:Animals, Newborn; D001927:Brain Diseases / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D004268:DNA-Binding Proteins / Q000096:biosynthesis*; D018846:Excitatory Amino Acids / Q000633:toxicity*; D007150:Immunohistochemistry; D016328:NF-kappa B / Q000096:biosynthesis*; D051381:Rats; D050796:STAT3 Transcription Factor; D015534:Trans-Activators / Q000096:biosynthesis*
D000209:Acute-Phase Proteins; D004268:DNA-Binding Proteins; D018846:Excitatory Amino Acids; D016328:NF-kappa B; D050796:STAT3 Transcription Factor; C494088:Stat3 protein, rat; D015534:Trans-Activators