Cellular target of UVB-induced DNA damage resulting in local suppression of contact hypersensitivity.
Experimental data are reviewed that lend support to the hypothesis that formation of DNA damage is the initiation event of local suppression of contact hypersensitivity (CHS) after exposure to ultraviolet (UV) radiation and that the antigen-presenting cell (APC) is an important target for this DNA damage.
Department of Molecular Toxicology, TNO Nutrition and Food Research Institute, Zeist, Netherlands.
A A
AA
Vink
V
V
Shreedhar
L
L
Roza
J
J
Krutmann
M L
ML
Kripke
D000818:Animals; D002478:Cells, Cultured; D004247:DNA / Q000528:radiation effects*; D004249:DNA Damage; D003877:Dermatitis, Contact / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007165:Immunosuppression Therapy; D008957:Models, Genetic; D018448:Models, Immunological; D014466:Ultraviolet Rays
D004247:DNA