Relationships between insulin resistance and lipoproteins in nondiabetic African Americans, Hispanics, and non-Hispanic whites: the Insulin Resistance Atherosclerosis Study.
The study purpose was to explore the association between dyslipidemia and insulin resistance in three ethnic groups. The Insulin Resistance Atherosclerosis Study (IRAS) is a multicenter epidemiologic study conducted at four clinical centers in California, Texas, and Colorado. The study population for this analysis consisted of 931 non-Hispanic white, African American, and Hispanic men and women (aged 45 to 64 years) without diabetes. The IRAS clinical examinations included lipoprotein measures, a 75-g glucose tolerance test, and the frequently sampled intravenous glucose tolerance (FSIGT) test. The results show a consistent relationship between insulin-mediated glucose disposal and dyslipidemia in African American, Hispanic, and non-Hispanic white men and women. Further, LDL size was inversely associated with insulin resistance in all three ethnic groups. These findings indicate that dyslipidemia is a fundamental part of the insulin resistance syndrome in all of the ethnic groups studied.
Howard
B V
BV
Medlantic Research Institute, Washington, DC 20010-2933, USA.
Mayer-Davis
E J
EJ
Goff
D
D
Zaccaro
D J
DJ
Laws
A
A
Robbins
D C
DC
Saad
M F
MF
Selby
J
J
Hamman
R F
RF
Krauss
R M
RM
Haffner
S M
SM
D000328:Adult; D000368:Aged; D044383:Black People; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D007333:Insulin Resistance; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D044465:White People; D001741:Black or African American
D008074:Lipoproteins