Antitumor activity of new derivatives of 1,3-diazaheterocycles.
2-Naphthylidene derivatives of 1,3-diazaheterocycles were prepared in order to investigate the relationship between their structure and anticancer activity. Preliminary screening in the standard in vitro assay using 60-tumor cell lines showed that some of these derivatives exhibited a moderate growth inhibition activity on various tumor subpanel cell lines between 10(-6)-10(-4) molar concentration. The results obtained show that the structural features are important in inhibiting tumor cell lines.
Department of Pharmaceutical Chemistry and Drug Analysis, Medical University of Lódź, Poland.
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D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004354:Drug Screening Assays, Antitumor; D006573:Heterocyclic Compounds, 1-Ring / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D019380:Anti-HIV Agents; D000970:Antineoplastic Agents; D001372:Aza Compounds; D006573:Heterocyclic Compounds, 1-Ring; D009281:Naphthalenes