Naloxone-precipitated morphine withdrawal induced place aversions: effect of naloxone at 24 hours postmorphine.
The aversive properties of naloxone-precipitated withdrawal from acutely administered morphine were assessed using the place-conditioning paradigm. The conditioned place aversion produced by naloxone (0.5-1.0 mg/kg, s.c.) after two conditioning trials was enhanced by pretreatment with morphine (20 mg/kg, s.c.) 24 h prior to the conditioning trial. Naloxone precipitated withdrawal from acutely administered morphine produces an aversive motivational state that becomes associated with place cues.
Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada.
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Parker
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Joshi
D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000494:pharmacology*; D009294:Narcotics / Q000494:pharmacology*; D011597:Psychomotor Performance / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013375:Substance Withdrawal Syndrome; D013649:Taste
D009292:Narcotic Antagonists; D009294:Narcotics; D009270:Naloxone; D009020:Morphine