The pathogenesis of HLA-B27 arthritis: role of HLA-B27 in bacterial defense.
The way in which a host accommodates invasive facultative intracellular bacteria must be the key to the development of reactive arthritis. Investigators have analyzed the bacterial events at several levels: invasion into host cells, intracellular survival, translocation from the sites of infection to the joints, residence in the joints, and evasion of host defense. Because HLA-B27 is present in higher incidence in patients with reactive arthritis and is an essential gene in the related ankylosing spondylitis, the role of HLA-B27 in host defense is also assumed to be important in the development of reactive arthritis. This review summarizes the various studies in this field.
Rheumatology Division, UCLA School of Medicine, Los Angeles, California, USA.
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M
Ikeda
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DT
Yu
D001170:Arthritis, Infectious / Q000235:genetics / Q000276:immunology*; D016918:Arthritis, Reactive / Q000235:genetics / Q000276:immunology*; D001419:Bacteria / Q000472:pathogenicity; D001424:Bacterial Infections / Q000235:genetics / Q000276:immunology*; D018407:Bacterial Physiological Phenomena; D015796:HLA-B27 Antigen / Q000235:genetics / Q000276:immunology*; D006801:Humans; D013167:Spondylitis, Ankylosing / Q000235:genetics / Q000276:immunology*
D015796:HLA-B27 Antigen