Cobalamin-dependent methionine synthase and serine hydroxymethyltransferase: targets for chemotherapeutic intervention?
Chemotherapeutic drugs targeted at folate-dependent reactions have typically been directed at a limited number of target enzymes: dihydrofolate reductase, thymidylate synthase, and GAR and AICAR transformylase. This review discusses two other potential targets for chemotherapeutic inhibition: cobalamin-dependent methionine synthase and serine hydroxymethyltransferase. Brief reviews of the catalytic properties of these two enzymes are presented, and possible strategies for chemotherapeutic intervention are discussed.
Biophysics Research Division, University of Michigan, Ann Arbor 41809-1055, USA.
R G
RG
Matthews
J T
JT
Drummond
H K
HK
Webb
D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / Q000037:antagonists & inhibitors*; D000241:Adenosine / Q000031:analogs & derivatives / Q000494:pharmacology; D015195:Drug Design; D004358:Drug Therapy; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D012696:Glycine Hydroxymethyltransferase / Q000037:antagonists & inhibitors*; D006801:Humans; D007700:Kinetics; D015394:Molecular Structure; D013912:Threonine / Q000031:analogs & derivatives / Q000378:metabolism; D014155:Transcobalamins / Q000378:metabolism
D004791:Enzyme Inhibitors; D014155:Transcobalamins; D013912:Threonine; D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; D012696:Glycine Hydroxymethyltransferase; D000241:Adenosine; C006235:sinefungin