[Antioxidative mechanisms in response to reactive forms of oxygen, apoptosis and differentiation of myogenic cells].
In this paper regard was put on contemporary matters related to apoptosis of myogenic cells of different types (myocardium, visceral, skeletal muscle) and updated theories on the action mechanisms of free radicals and their contribution to this process. Concern was put on the activity of certain growth factors and antioxidants belonging to group of polyphenols on the extent of apoptosis in myoblasts held in culture. Similarities between the pathways depicting the process of muscle differentiation and resistance to programmed cell death are presented. The concept of myogenic cell differentiation and implications to apoptosis induced by particular oxidants is extensively discussed.
Katedra Fizjologii Zwierzat, Wydziału Weterynaryjnego Szkoły Głównej Gospodarstwa Wiejskiego w Warszawie.
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Orzechowski
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Motyl
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Płoszaj
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D017209:Apoptosis / Q000502:physiology*; D002454:Cell Differentiation; D002478:Cells, Cultured; D005609:Free Radicals / Q000378:metabolism; D006133:Growth Substances / Q000378:metabolism; D006801:Humans; D009132:Muscles / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*
D000975:Antioxidants; D005609:Free Radicals; D006133:Growth Substances; D017382:Reactive Oxygen Species
Méchanizmy antyoksydacyjne w odpowiedzi na reaktywne formy tlenu a nekrobiologia i róznicowanie komórek miogennych.