Usefulness of intravenous metoprolol to prevent syncope induced by head-up tilt.
Intravenous metoprolol was found to be significantly more effective than placebo in preventing head-up tilt-table induced neurally mediated syncope. The reproducibility of acute tilt-table testing is only 63% and suggests caution in the interpretation of acute drug testing during tilt-table studies.
Department of Pharmacy, Hartford Hospital, Connecticut 06102-5037, USA.
J
J
Kluger
M
M
Bazunga
R
R
Goldman
E
E
O'Rangers
P
P
Azar
M S
MS
Chow
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D000328:Adult; D000368:Aged; D018660:Blood Pressure Monitoring, Ambulatory; D004311:Double-Blind Method; D015716:Electrocardiography, Ambulatory; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008790:Metoprolol / Q000008:administration & dosage*; D008875:Middle Aged; D011187:Posture; D015203:Reproducibility of Results; D055502:Secondary Prevention; D013575:Syncope / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D016896:Treatment Outcome
D000319:Adrenergic beta-Antagonists; D008790:Metoprolol