The role of CD8+ cells and CD11a in the rejection-reaction of the allogeneic microskin grafting.
By using histological tissue sections and immunohistochemical stains, the rejection-reaction of the allogeneic microskin grafting of rabbit-skin wounds was studied. The results revealed that the rejection started early in the days following transplantation. In the second week following transplantation, severe graft rejection with epithelial destruction was noted. In addition, an increase of CD8+ cells and expression of the adhesion molecule-CD11a-were also noticed and persisted throughout the days following transplantation. These findings suggest that the CD8+ cells and CD11a may play a major role in the rejection of allogeneic skin grafting.
Lin
S D
SD
Department of Surgery, Kaohsiung Medical College Hospital, Taiwan, Republic of China.
Chai
C Y
CY
Tsai
C C
CC
Chou
C K
CK
Lin
T M
TM
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000502:physiology*; D006084:Graft Rejection / Q000209:etiology*; D007150:Immunohistochemistry; D016169:Lymphocyte Function-Associated Antigen-1 / Q000502:physiology*; D011817:Rabbits; D016038:Skin Transplantation / Q000276:immunology*; D014184:Transplantation, Homologous
D016169:Lymphocyte Function-Associated Antigen-1