Genetic polymorphism of 4'-hydroxylation of S-mephenytoin in 148 Chinese of Han nationality.
OBJECTIVE
To study genetic polymorphism of S-mephenytoin (S-Mep) 4'-hydroxylation in the Chinese population of Han nationality.


METHODS
The lg metabolic ratio (MR) and lg hydroxylation index (HI) in the urine (0-12 h) after oral administration with 100 mg of racemic Mep tablet were determined by HPLC method in 148 consangeously unrelated native Chinese subjects and 21 individuals of 5 families.


RESULTS
The lg MR and lg HI showed a bimodal distribution with an antimode of -1.00 and 1.50, respectively. The occurrence of poor metabolizers (PM) was 13.5% in the population. The pedigree analysis in 5 families indicated that deficient S-Mep hydroxylation was an autosomal recessive trait.


CONCLUSIONS
The occurrence of PM for S-Mep 4-hydroxylation in Chinese was higher than that of the Caucasians, and both genetic modes were of autosomal recessive trait.
Institute of Clinical Pharmacology, Zhejiang Medical University, Hangzhou, China.
Z R
ZR
Ruan
Y S
YS
Cheng
J F
JF
Zhou
Y
Y
Zhao
Y Z
YZ
Pan
D Y
DY
Ding
D000328:Adult; D044466:Asian People; D002681:China; D005260:Female; D006801:Humans; D006900:Hydroxylation; D008297:Male; D008617:Mephenytoin / Q000378:metabolism*; D010375:Pedigree; D011110:Polymorphism, Genetic; D013045:Species Specificity
D008617:Mephenytoin