[Value of antibody titers for diagnosis of neuroborreliosis].
Neuroborreliosis is a very frequent subtype of infection with Borrelia burgdorferi. Because of the widely spread inapparent infections finding of diagnosis by analysis of serum antibodies is very difficult. In the years 1990-1994 the serum of 6.775 patients of the Department of Neurology in Homburg, Germany was analysed with regard to Borrelia burgdorferi specific IgG antibodies. 24% showed a positive serum titer and 20% a borderline result. 73 patients showed a specific intrathecal IgG antibody synthesis. In contrast to patients with antibodies in serum these patients showed a significant cumulation during summer. The high percentage of positive serum titers and the season independence support the assumption of widely spread inapparent infections. If a patient shows neurological symptoms the finding of serum antibodies against Borrelia burgdorferi is not sufficient for the diagnosis of Neuroborreliosis. A specific intrathecal synthesis of antibodies, is the most reliable serological indicator for Neuroborreliosis. Intrathecal synthesis usually starts three to four weeks after the first clinical symptoms.
Neurologische Klinik, Universitätskliniken des Saarlandes, Homburg/Saar.
R
R
Woessner
J
J
Treib
A
A
Haass
M
M
Stoll
G
G
Holzer
K
K
Schimrigk
D000907:Antibodies, Bacterial / Q000134:cerebrospinal fluid*; D000918:Antibody Specificity / Q000276:immunology; D015748:Borrelia burgdorferi Group / Q000276:immunology*; D002494:Central Nervous System Infections / Q000175:diagnosis* / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid*; D008193:Lyme Disease / Q000175:diagnosis* / Q000276:immunology; D020019:Neurocysticercosis; D009460:Neurologic Examination; D012016:Reference Values; D012621:Seasons; D012680:Sensitivity and Specificity
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G
Wertigkeit von Antikörpertitern für die Diagnose einer Neuroborreliose.