[The diagnosis and treatment of a secondary antiphospholipid syndrome in systemic lupus erythematosus].
OBJECTIVE
The study of incidence of clinico-laboratory signs of antiphospholipid syndrome (APLS) and the results of its treatment in SLE.


METHODS
Out of 120 patients with verified SLE, 13 (10.8%) had the signs of APLS. They underwent additional tests (platelet and lupus blood anticoagulant assays, assessment of immunity).


RESULTS
APLS treatment consisted of suppression of antiphospholipid antibodies production by glucocorticosteroids and cytostatics, removal of antibodies by means of plasmapheresis, HBO therapy of thromboses and vascular defects. APLS in SLE frequently manifested with arterial thromboses, cerebrovasculitis, livedo, thrombocytopenia, lupus anticoagulant.


CONCLUSIONS
Combined treatment of APLS in SLE improves the disease prognosis and prolongs life span.
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Komarov
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D016736:Antiphospholipid Syndrome / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D002908:Chronic Disease; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged
Diagnostika i lechenie vtorichnogo antifosfolipidnogo sindroma pri sistemnoĭ krasnoĭ volchanke.