Size control: cell proliferation does not equal growth.
Division subdivides mass without increasing it. So one should not expect that an increase in cell division would make an organism bigger. Both classic and recent experiments confirm this simple rationale: altering proliferation produces normally sized body structures with either especially small or exceptionally large cells.
Department of Biochemistry and Biophysics, University of California San Francisco 94143-0448, USA. tintin@cgl.ucsf.edu
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D000818:Animals; D016203:CDC2 Protein Kinase / Q000502:physiology; D002352:Carrier Proteins; D018797:Cell Cycle Proteins / Q000502:physiology; D002455:Cell Division; D048429:Cell Size; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000166:cytology / Q000196:embryology / Q000254:growth & development; D050684:E2F Transcription Factors; D004625:Embryo, Nonmammalian; D006128:Growth / Q000502:physiology*; D019476:Insect Proteins / Q000502:physiology; D010749:Phosphoprotein Phosphatases / Q000502:physiology; D011679:Pupa; D056465:Retinoblastoma-Binding Protein 1; D015534:Trans-Activators; D014157:Transcription Factors / Q000172:deficiency / Q000502:physiology; D014921:Wings, Animal / Q000166:cytology / Q000196:embryology / Q000254:growth & development; D020687:cdc25 Phosphatases
D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; C088053:Dp transcription factor, Drosophila; D029721:Drosophila Proteins; D050684:E2F Transcription Factors; D019476:Insect Proteins; D056465:Retinoblastoma-Binding Protein 1; D015534:Trans-Activators; D014157:Transcription Factors; D016203:CDC2 Protein Kinase; D010749:Phosphoprotein Phosphatases; D020687:cdc25 Phosphatases