[Growth hormone and its effects on cholesterol and lipoprotein metabolism following surgical intervention (hGH and cholesterol metabolism during surgery)].
The objective of this work was to determine whether the increase in serum GH, IGF1, glucose and insulin levels caused by the administration of hGH modifies the normal response of cholesterol and lipoproteins to surgical aggression. A prospective, randomized, and double blind study is carried out in 28 patients operated for gallstones and diverticulitis. The control group (n = 15) was not given anything except conventional fluidtherapy in the postoperative period: the patients in the hGH (n = 13) group were also given 8 IU of hGH during the first five days after the intervention. The comparative study of the triglycerides, cholesterol, LDLc, HDL-c, and A-1 B apolipoproteins shows that in the group treated with hGH the normal response of cholesterol and lipoproteins to surgical aggression is attenuated.
Cátedra de Bioquímica y Fisiología, Hospital Clínico San Cecilio, Facultad de Medicina de Granada, España.
R
R
Martín
M D
MD
Cano
J A
JA
Guerrero
E
E
Segovia
R
R
Vara Thorbeck
D000368:Aged; D002763:Cholecystectomy; D002769:Cholelithiasis / Q000601:surgery*; D002784:Cholesterol / Q000378:metabolism*; D004238:Diverticulitis / Q000601:surgery*; D004311:Double-Blind Method; D005260:Female; D019382:Human Growth Hormone / Q000032:analysis*; D006801:Humans; D010535:Laparoscopy; D008074:Lipoproteins / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011446:Prospective Studies
D008074:Lipoproteins; D019382:Human Growth Hormone; D002784:Cholesterol
La hormona de crecimiento y sus efectos sobre el metabolismo del colesterol y lipoproteínas postagresión quirúrgica (hGH y metabolismo del colesterol tras la cirugía).