[Chromosome sensitivity to bleomycin-induced damage in patients with laryngeal cancer as a marker of genetic risk].
An inter-individual variability in sensitivity to mutagen-induced genotoxicity was studied in respect to an estimation of larynx cancer risk. Bleomycin induced chromosome breaks were analysed in blood lymphocytes proliferating in vitro in a group of 35 larynx cancer subjects and in 18 healthy controls. A significantly higher index of chromosome breaks was found in larynx cancer subjects as compared with the controls. The distribution of individual results indicates that subjects oversensitive to bleomycine were identified only among laryngeal tumour patients. A potential usage of bleomycin test in tumour prognosis is discussed.
Klinika Otolaryngologii AM im. K. Marcinkowskiego w Poznaniu.
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Dabrowski
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Piatkowski
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Szyfter
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Szmeja
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Szyfter
D000328:Adult; D000368:Aged; D001761:Bleomycin / Q000009:adverse effects*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000235:genetics*; D002875:Chromosomes / Q000187:drug effects* / Q000235:genetics; D004249:DNA Damage / Q000187:drug effects* / Q000235:genetics; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007822:Laryngeal Neoplasms / Q000175:diagnosis* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity
D001761:Bleomycin
Wrazliwość chromosomów na uszkodzenia indukowane bleomycyna u chorych na raka krtani jako marker podatności na rozwój choroby nowotworowej.