Detection of abnormal lymphocytes in the blood of Balb/c mice infected with murine gammaherpesvirus strain 72: the analogy with Epstein-Barr virus infection.
We have followed the effect of murine gammaherpesvirus strain 72 (MHV-72) infection and immunosuppression on the differential white blood cell count of Balb/c mice. In both the acute and chronic phase of infection, abnormal lymphocytes resembling human B lymphocytes infected with Epstein-Barr virus (EBV) were detected. Immunosuppression had no significant effect on the haematological changes during the infection. Some of mice, which had developed tumours as a consequence of infection, showed splenomegaly, lymphadenopathy, leukocytosis and high percentage of immature blastic forms of leukocytes.
Department of Microbiology and Virology, Faculty of Natural Sciences, Comenius University, Bratislava, Slovak Republic.
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Mistríková
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M
Mrmusová
D000208:Acute Disease; D000818:Animals; D002522:Chlorocebus aethiops; D002908:Chronic Disease; D018142:Gammaherpesvirinae / Q000472:pathogenicity*; D006566:Herpesviridae Infections / Q000276:immunology / Q000473:pathology; D006801:Humans; D007244:Infectious Mononucleosis / Q000276:immunology*; D007962:Leukocytes / Q000473:pathology*; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D018146:Muromegalovirus / Q000472:pathogenicity*; D014709:Vero Cells