Inducers of the cytochrome P-450 superfamily as promoters of carcinogenesis.
This review summarizes data on the mechanisms of tumor-promoting activity of non-genotoxic compounds that are inducers of cytochrome P-450 isoforms. Their promoting activity is analyzed in term of synthesis of new cytochrome P-450 isoforms. Active oxygen species formed by cytochrome P-450 isoforms can simultaneously act as stimulators of proliferation and inhibitors of intercellular communications. Promoter effects can be associated with changes in the ratio of cellular signaling non-protein molecules induced by newly synthesized cytochrome P-450 isoforms. Data on induction of cytochrome P-450 isoforms of family 1 indicate that inducer interaction with its receptor causes cellular events resulting in the stimulation of cell proliferation.
Koblyakov
V A
VA
Institute of Carcinogenesis, Blokhin Oncology Research Center, Russian Academy of Medical Sciences, Moscow, 115478, Russia.
D000818:Animals; D002273:Carcinogens / Q000494:pharmacology; D002450:Cell Communication / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D004790:Enzyme Induction; D006801:Humans; D007527:Isoenzymes / Q000096:biosynthesis; D009369:Neoplasms / Q000139:chemically induced / Q000473:pathology*
D002273:Carcinogens; D007527:Isoenzymes; D003577:Cytochrome P-450 Enzyme System