Inhibitory actions of various vasorelaxants on the myogenic contraction induced by quick stretch studied in canine cerebral artery.
Quick stretch at a rate of 10 cm/s with the amount of 30% of the initial muscle length (= 100%) produced a myogenic contraction in canine cerebral artery. The inhibitory actions of various vasorelaxants on the stretch-induced contraction were investigated. Ca2+ channel blockers (nicardipine, D-cis-diltiazem) inhibited the stretch-induced contraction by 50-60% at the concentrations which abolished high KCl-induced contraction. Inhibitions of the stretch-induced contraction by nitro-compounds (nitroglycerin, sodium nitroprusside) were about 50%. In contrast, inhibitions by the compounds which activate ATP-sensitive K+ channels (cromakalim, nicorandil, pinacidil) of the myogenic contraction in response to quick stretch were only 20%. Papaverine totally abolished the stretch-induced contraction. It is likely that all the vasorelaxant compounds tested in the present study except papaverine are beneficial in the sense that they do not suppress the intrinsic myogenic contraction, which may be related to the autoregulation of local blood flow.
Department of Pharmacology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
Y
Y
Tanaka
K
K
Shigenobu
K
K
Nakayama
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology; D002536:Cerebral Arteries / Q000187:drug effects / Q000502:physiology; D004285:Dogs; D004347:Drug Interactions; D005260:Female; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009574:Nitro Compounds / Q000494:pharmacology; D010208:Papaverine / Q000494:pharmacology; D011311:Pressoreceptors / Q000187:drug effects*; D014661:Vasoconstriction / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology*
D002121:Calcium Channel Blockers; D009574:Nitro Compounds; D014665:Vasodilator Agents; D010208:Papaverine