Encouraging response of an advanced steroid-cell tumor to GnRH agonist therapy.
BACKGROUND
Chemotherapy for steroid tumors of unspecified type has met with limited success and the overall prognosis has been poor.


METHODS
A patient with a virilizing steroid tumor, otherwise unspecified, with demonstrated progressive disease after surgical debulking. Treatment with multiagent chemotherapy failed, but the patient subsequently had a robust response to GnRH agonist therapy.


CONCLUSIONS
GnRH analogue treatment should be considered prior to cytotoxic chemotherapy in cases of steroid tumor, not otherwise specified.
Department of Obstetrics and Gynecology, Southern Illinois University School of Medicine, and St. John's Hospital, Springfield 62794-1315, USA.
C A
CA
Brewer
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D
Shevlin
D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D016729:Leuprolide / Q000627:therapeutic use*; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology; D012074:Remission Induction
D018931:Antineoplastic Agents, Hormonal; D016729:Leuprolide