Transplantation for adrenoleukodystrophy with HLA-A and B nonidentical paternal marrow: report of one case.
We report the result of allogeneic bone marrow transplantation (BMT) in a 14-year-old boy who was neurologically severely involved with the childhood form of adrenoleukodystrophy (ALD) and received marrow from his HLA-A and B nonidentical, MLC-nonreactive paternal donor without T-cell depletion processing. Bone marrow transplantation corrected the excess content of very long chain fatty acid in plasma but did not arrest the deterioration of the neurological status during 3.5-year post-transplant follow-up period. Since partially matched or unrelated donors have been applied to clinical BMT successfully with current new techniques, ALD patients will have a better prognosis when they are transplanted in status of mild and early involvement. Our first experience may be helpful in more trials of BMT for genetic leukodystrophy in Taiwan.
Lin
H C
HC
Department of Pediatrics, En Chu Kong Hospital, San-Shia, Taipei, Taiwan, R.O.C.
Lin
K H
KH
Wang
P J
PJ
D000293:Adolescent; D000326:Adrenoleukodystrophy / Q000097:blood / Q000276:immunology / Q000601:surgery*; D016026:Bone Marrow Transplantation / Q000276:immunology*; D015234:HLA-A Antigens / Q000032:analysis*; D015235:HLA-B Antigens / Q000032:analysis*; D006650:Histocompatibility Testing; D006801:Humans; D019520:Living Donors; D008297:Male
D015234:HLA-A Antigens; D015235:HLA-B Antigens