The inhibition of human neuronal K+ currents by general anesthetic agents is altered by extracellular K.
We demonstrate for the first time that the extracellular potassium concentration influences the inhibition of human neuronal delayed rectifier potassium currents by general anesthetics. This observation suggests a modulatory role for extracellular potassium ions in the action of some general anesthetic agents.
Department of Anesthesiology, University of Bonn, Bonn, Germany.
P
P
Friederich
B W
BW
Urban
D018681:Anesthetics, General / Q000494:pharmacology*; D005045:Etomidate / Q000494:pharmacology; D006801:Humans; D007649:Ketamine / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D009447:Neuroblastoma; D009474:Neurons / Q000502:physiology*; D011188:Potassium / Q000494:pharmacology / Q000502:physiology*; D026902:Potassium Channel Blockers; D015221:Potassium Channels / Q000502:physiology*; D015742:Propofol / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D018681:Anesthetics, General; D026902:Potassium Channel Blockers; D015221:Potassium Channels; D007649:Ketamine; D011188:Potassium; D015742:Propofol; D005045:Etomidate