A pilot double-blind, randomized, and placebo-controlled study of orally administered IFN-alpha-n1 (Ins) in pediatric patients with measles.
To determine the safety and effectiveness of low-dose oral interferon-alpha (IFN-alpha) against measles, 30 confined pediatric patients were prospectively and randomly assigned to either a placebo or an oral IFN-alpha group and observed daily for 14 days in a double-blind manner. The IFN patients received a daily sublingual dose of 200 IU of human lymphoblastoid IFN-alpha. The IFN-treated group showed shorter average duration of malaise (3.2 vs. 10.7 days, p < 0.0001), anorexia (3.1 vs. 6.7 days, p < 0.0001), and irritability (1.1 vs. 2.2 days, p < 0.01) and shorter duration of macular/maculopapular/papular lesions (4.3 vs. 8.2 days,p < 0.0001) and branny desquamation (4.6 vs. 5.8 days, p > 0.05) and shorter time for rash to become generalized (5.5 vs. 10.3 days, p < 0.0001). No hematologic, renal, or liver toxicities were noted. It, therefore, appears that low-dose oral human lymphoblastoid IFN-alpha used in this pilot study is both safe and effective in children with measles infection.
Lecciones
J A
JA
Philippine Children's Medical Center, Quezon City, Metro Manila. amyml@psdn.org.ph
Abejar
N H
NH
Dimaano
E E
EE
Bartolome
R
R
Cinco
S
S
Mariano
N
N
Yerro
M E
ME
Cobar
S
S
Fuggan
B
B
D000284:Administration, Oral; D000293:Adolescent; D000998:Antiviral Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007223:Infant; D016898:Interferon-alpha / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008457:Measles / Q000188:drug therapy*; D010865:Pilot Projects; D010919:Placebos
D000998:Antiviral Agents; D016898:Interferon-alpha; D010919:Placebos