[Xalathane: comparative assessment of efficacy and safety in hypotensive therapy of glaucoma].
Hypotensive efficacy and safety of local monotherapy with 0.005% xalathane (once a day) and combined therapy with 0.5% timolol (twice a day) and 2% pilocarpine (3 times a day) are compared in 24 patients with primary open-angle glaucoma. Mean decrease of intraocular pressure was significant in both groups. No side effects of xalathane were recorded. In one case there was a slight reddening of the eye and a sensation of discomfort Pilocarpine therapy was associated with miosis in all patients; half of them complained of obscure vision and headache after instillation. Monotherapy with xalathane is safe sufficiently effective, and comparable to combined therapy with timolol and pilocarpine.
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VP
Erichev
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LV
Iakubova
D000293:Adolescent; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use; D000368:Aged; D004359:Drug Therapy, Combination; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D000077338:Latanoprost; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D010277:Parasympathomimetics / Q000008:administration & dosage / Q000627:therapeutic use; D010862:Pilocarpine / Q000008:administration & dosage / Q000627:therapeutic use; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage / Q000627:therapeutic use*; D012449:Safety; D013999:Timolol / Q000008:administration & dosage / Q000627:therapeutic use; D016896:Treatment Outcome
D000319:Adrenergic beta-Antagonists; D009883:Ophthalmic Solutions; D010277:Parasympathomimetics; D011461:Prostaglandins F, Synthetic; D010862:Pilocarpine; D000077338:Latanoprost; D013999:Timolol
Ksalatan: sravnitel'naia otsenka éffektivnosti i bezopasnosti v gipotenzivnoĭ terapii glaukomy.