Simultaneous analysis of multiple gene expression patterns as a function of development, injury or senescence.
Concurrent changes in expression of eight genes were examined following cryogenic rat brain injury. Cortical RNA levels were catalogued at time 0, and at 1 h and 1 week following injury. The genes include thymidine kinase (TK), c-fos, renin, myelin basic protein (MBP), proteolipid protein (PLP), glial fibrillary acidic protein (GFAP), insulin-like growth factor-1 (IGF-1), and somatostatin. All demonstrate increased expression following injury. Renin and c-fos exhibit detectable changes as early as 1 h post-injury.
Cook
J L
JL
Ochsner Medical Foundation, Division of Research, New Orleans, LA, USA. jcook@ochsner.org
Marcheselli
V
V
Alam
J
J
Deininger
P L
PL
Bazan
N G
NG
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001930:Brain Injuries / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D006801:Humans; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats
D012333:RNA, Messenger