Effects of massive transfusion on oxygen availability.
OBJECTIVE
To determine oxygen derived parameters, hemodynamic and biochemical laboratory data (2,3 Diphosphoglycerate, lactate and blood gases analysis) in patients after cardiac surgery who received massive blood replacement.


METHODS
Prospective study.


METHODS
Heart Institute (Instituto do Caração), Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, Brazil.


METHODS
Twelve patients after cardiac surgery who received massive transfusion replacement; six of them evolved to a fatal outcome within the three-day postoperative follow-up.


RESULTS
The non-survivors group (n = 6) presented high lactate levels and low P50 levels, when compared to the survivors group (p < 0.05). Both groups presented an increase in oxygen consumption and O2 extraction, and there were no significant differences between them regarding these parameters. The 2,3 DPG levels were slightly reduced in both groups.


CONCLUSIONS
This study shows that patients who are massively transfused following cardiovascular surgery present cell oxygenation disturbances probably as a result of O2 transport inadequacy.
Heart Institute, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, Brazil.
J O
JO
Auler Júnior
E
E
Bonetti
A C
AC
Hueb
F R
FR
Gallas
M J
MJ
Carmona
D019794:2,3-Diphosphoglycerate / Q000097:blood; D000704:Analysis of Variance; D001784:Blood Gas Analysis; D001803:Blood Transfusion; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D006439:Hemodynamics; D006801:Humans; D019344:Lactic Acid / Q000097:blood; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D011183:Postoperative Complications; D011446:Prospective Studies; D012771:Shock, Hemorrhagic / Q000209:etiology / Q000628:therapy*; D013997:Time Factors
D019794:2,3-Diphosphoglycerate; D019344:Lactic Acid; D010100:Oxygen