Recent advances in the pharmacology of nerve-injury pain.
Nerve injury pain remains a complex clinical challenge. Although the development of animal models of nerve injury pain has aided our understanding of potential pathophysiologic mechanisms for this condition, effective treatment still remains beyond our reach. Several classes of agents appear to block pain behavior in these animal models and humans, but they are often limited in their use by low efficacy, or undesirable side-effects. A prerequisite for the improvement of nerve injury pain includes the development of clinically-relevant animal models in which therapeutic targets can be identified.
Molecular Neurobiology of Pain Laboratory, Anesthesia Research, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
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D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D009437:Neuralgia / Q000188:drug therapy / Q000503:physiopathology*; D059348:Peripheral Nerve Injuries; D010525:Peripheral Nerves / Q000187:drug effects / Q000503:physiopathology; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000502:physiology*; D016896:Treatment Outcome
D000700:Analgesics; D017981:Receptors, Neurotransmitter