Sequence and expression levels in human tissues of a new member of the aldo-keto reductase family.
We have isolated a human cDNA clone from small intestine that represents a new member of the aldo-keto reductase family. This new member showed 70% identity at the protein level to human aldose reductase and around 80% identity to other Chinese hamster and mouse reductases. The expression pattern shows that this message is located primarily in the adrenal gland, thus suggesting an involvement in steroid metabolism. It is also strongly expressed in the intestinal tract and has been called human small intestine reductase.
Hyndman
D J
DJ
Department of Biochemistry, Queen's University, Kingston, Canada.
Flynn
T G
TG
D000311:Adrenal Glands / Q000201:enzymology; D000429:Alcohol Oxidoreductases / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics*; D000449:Aldehyde Reductase / Q000737:chemistry / Q000235:genetics; D000074408:Aldo-Keto Reductases; D000595:Amino Acid Sequence; D001483:Base Sequence; D018076:DNA, Complementary / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D007421:Intestine, Small / Q000201:enzymology*; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid
D018076:DNA, Complementary; D000429:Alcohol Oxidoreductases; D000074408:Aldo-Keto Reductases; D000449:Aldehyde Reductase; C000614209:AKR7A5 protein, mouse