Indinavir nephropathy in an AIDS patient with renal insufficiency and pyuria.
Indinavir has been described to cause crystalluria and nephrolithiasis in a variable number of treated patients. Acute renal failure, often reversible with discontinuation of the medication, induction of a diuresis and correction of urinary obstruction if present, occurs in a smaller percent of patients. One recent report described renal biopsy findings, indinavir crystals within cellular casts in the collecting tubules, in a patient receiving this antiretroviral agent. We report a second case of a patient with mild renal insufficiency and pyuria following indinavir therapy and describe similar renal biopsy findings.
Department of Medicine, Yale University School of Medicine, New Haven, CT 06520-8029, USA.
M A
MA
Perazella
M
M
Kashgarian
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E
Cooney
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D001706:Biopsy; D004359:Drug Therapy, Combination; D017320:HIV Protease Inhibitors / Q000009:adverse effects*; D015497:HIV-1; D006801:Humans; D019469:Indinavir / Q000009:adverse effects*; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011776:Pyuria / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D013997:Time Factors
D017320:HIV Protease Inhibitors; D019469:Indinavir