Aspirin and paracetamol tolerance in patients with nimesulide-induced urticaria.
BACKGROUND
The administration of aspirin and other nonsteroidal anti-inflammatory drugs in patients sensitive to nimesulide might be hazardous.


OBJECTIVE
To assess the tolerance to both acetaminophen (paracetamol) and aspirin in patients with a history of urticaria induced by nimesulide.


METHODS
Nine patients with a history of nimesulide intolerance were submitted to single-blind, placebo-controlled peroral challenges with increasing doses of acetaminophen and aspirin.


RESULTS
Acetaminophen was tolerated by all patients, whereas two experienced immediate systemic urticaria after the administration of 125 mg of aspirin.


CONCLUSIONS
Acetaminophen and aspirin are well tolerated by most nimesulide-sensitive patients. Since a minority of patients show aspirin sensitivity, tolerance of this agent should always be ascertained by properly performed peroral challenges.
Asero
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Ambulatorio di Allergologia, Ospedale Caduti Bollatesi, Bollate (MI), Italy.
D000082:Acetaminophen / Q000276:immunology*; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000276:immunology*; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology / Q000276:immunology; D004361:Drug Tolerance / Q000276:immunology; D005260:Female; D006801:Humans; D007108:Immune Tolerance; D008297:Male; D008875:Middle Aged; D013449:Sulfonamides / Q000009:adverse effects*; D014581:Urticaria / Q000139:chemically induced*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D013449:Sulfonamides; D000082:Acetaminophen; D001241:Aspirin; C012655:nimesulide