Structural specificity of serotonin effect on human erythrocyte fragility.
Serotonin, a neurotransmitter and vasoconstrictor, affects various cell properties. We have analyzed the importance of its structural components for its extensive effect on human erythrocyte fragility, using its O- and N-linked derivatives and related compounds. The results presented in this communication indicate that the amino group, free of adjacent negative charges, and the hydroxyl group are indispensable for the serotonin-induced increase in red blood cell fragility.
Gilboa-Garber
N
N
Department of Life Sciences, Bar-Ilan University, Ramat-Gan, 52900, Israel.
Kirstein-Segal
R
R
D002463:Cell Membrane Permeability / Q000187:drug effects; D004910:Erythrocyte Membrane / Q000187:drug effects; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D009995:Osmosis; D012701:Serotonin / Q000737:chemistry / Q000494:pharmacology*
D012701:Serotonin