Fatal adverse event secondary to high osmolality contrast agent.
Adverse drug events secondary to iodinated contrast agents are of particular concern to all clinicians. Despite the availability of newer agents, the mortality rates remain unchanged. We describe a fatal adverse event secondary to use of the high osmolality agent iothalmate meglumine 30%. A 58-y-old healthy female with no previous history of drug or food allergy had cardiac arrest toward the end of the i.v. infusion of the contrast agent during a CT scan. The patient expired despite aggressive therapeutic measures.
Department of Medicine, University Hospital, State University of New York Health Science Center at Syracuse 13210, USA.
R
R
Guharoy
J
J
Medicis
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D
Lehmann
D003287:Contrast Media / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008536:Meglumine / Q000009:adverse effects* / Q000031:analogs & derivatives; D008875:Middle Aged; D009994:Osmolar Concentration
D003287:Contrast Media; D008536:Meglumine