Distal sensory axonopathy after sarin intoxication.
A 51-year-old man inhaled sarin during a terrorist attack on the Tokyo subway system and died 15 months later. Neuropathologic examination revealed marked nerve fiber decrease in the sural nerve, moderate nerve fiber loss in the sciatic nerve, and unremarkable dorsal root ganglia, dorsal roots, and posterior column of the spinal cord. This pathology is consistent with dying-back degeneration of the peripheral nervous system and could represent a late sequela of sarin intoxication.
Department of Neurology, Graduate School of Medicine, the University of Tokyo, Japan.
K
K
Himuro
S
S
Murayama
K
K
Nishiyama
T
T
Shinoe
H
H
Iwase
M
M
Nagao
T
T
Takatori
I
I
Kanazawa
D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D019636:Neurodegenerative Diseases / Q000139:chemically induced* / Q000473:pathology*; D009475:Neurons, Afferent / Q000473:pathology* / Q000648:ultrastructure; D012524:Sarin / Q000506:poisoning*; D013116:Spinal Cord / Q000473:pathology; D013497:Sural Nerve / Q000473:pathology; D014041:Tokyo; D014754:Violence
D012524:Sarin