Role of the subthalamo-nigral input in the control of amygdala-kindled seizures in the rat.
The substantia nigra pars reticulata (SNpr) is a critical site for the control of epileptic seizures. Potentiation of the inhibitory GABAergic input from the striatum to the SNpr suppresses primary or secondary generalized seizures in the rat. The purpose of this study was to examine the possible involvement of the excitatory glutamatergic input from the subthalamic nucleus to the SNpr in the control of both the electroencephalographic and the motor components of amygdala-kindled seizures in the rat. Microinjections of either an N-methyl-D-aspartate (NMDA) antagonist in the substantia nigra or a GABAA agonist in the subthalamic nucleus, significantly reduced motor seizures but did not modified the afterdischarges. These results provide evidence for the involvement of the subthalamo-nigral projection in the modulation and the propagation of the motor components of amygdala-kindled seizures.
Deransart
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Neurobiologie et neuropharmacologie des épilepsies généralisées, INSERM U. 398, Faculté de Médecine, 11, rue Humann, 67085, Strasbourg Cedex, France. deransart@neurochem.u-strasbg.fr
Lê
B T
BT
Marescaux
C
C
Depaulis
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A
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D004558:Electric Stimulation; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D007839:Functional Laterality / Q000502:physiology; D018755:GABA Agonists / Q000494:pharmacology; D007696:Kindling, Neurologic; D008297:Male; D008845:Microinjections; D051381:Rats; D017208:Rats, Wistar; D017470:Receptors, Glutamate / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors; D012640:Seizures / Q000503:physiopathology*; D013378:Substantia Nigra / Q000502:physiology*; D013787:Thalamic Nuclei / Q000502:physiology*
D018691:Excitatory Amino Acid Antagonists; D018755:GABA Agonists; D017470:Receptors, Glutamate; D016194:Receptors, N-Methyl-D-Aspartate