Rodent malaria prophylaxis by transdermal delivery of primaquine.
The efficacy of a new transdermal delivery system of primaquine in order to obtain causal prophylaxis against sporozoite-induced Plasmodium yoelii infection was evaluated. A single administration of a 1.0 cm2 transdermal delivery system containing 5.0 mg of primaquine was able to protect 100% of treated mice. This result suggests that the transdermal route may be a very interesting approach for malaria prophylaxis and should encourage further studies in order to determine the absolute bioavailability of the drug as well as its dose-effect relationship.
Laboratoire de Physico-Chimie, Pharmacotechnie et Biopharmacie (URA CNRS 1218)-Université Paris-Sud, Chatenay-Malabry, France.
P
P
Mayorga
F
F
Miltgen
F
F
Coquelin
G
G
Couarraze
D000279:Administration, Cutaneous; D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage*; D004353:Drug Evaluation, Preclinical; D008288:Malaria / Q000517:prevention & control*; D051379:Mice; D018512:Parasitemia / Q000517:prevention & control; D010967:Plasmodium yoelii / Q000302:isolation & purification; D011319:Primaquine / Q000008:administration & dosage*; D013997:Time Factors
D000962:Antimalarials; D011319:Primaquine