Emergency and prolonged use of intravenous etomidate to control hypercortisolemia in a patient with Cushing's syndrome and peritonitis.
We report the emergency and prolonged use of etomidate to control circulating cortisol levels in a patient with Cushing's syndrome secondary to ectopic ACTH production from a pancreatic islet cell tumor. Duodenal perforation and peritonitis complicated an episode of salmonella septicemia, precluding the use of conventional oral medical adrenolytic therapy. Endogenous cortisol secretion was abolished by parenteral etomidate, allowing serum cortisol levels to be controlled with an iv infusion of hydrocortisone over an 8-week period in intensive care before definitive pancreatic surgery.
Drake
W M
WM
Department of Endocrinology, St. Bartholomew's Hospital, London, United Kingdom. w.m.drake@mds.qmw.ac.uk
Perry
L A
LA
Hinds
C J
CJ
Lowe
D G
DG
Reznek
R H
RH
Besser
G M
GM
D007516:Adenoma, Islet Cell / Q000378:metabolism / Q000601:surgery; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000328:Adult; D003480:Cushing Syndrome / Q000097:blood* / Q000150:complications / Q000209:etiology; D004632:Emergency Medical Services; D005045:Etomidate / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D006854:Hydrocortisone / Q000037:antagonists & inhibitors / Q000097:blood* / Q000627:therapeutic use; D007275:Injections, Intravenous; D008297:Male; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000601:surgery; D010538:Peritonitis / Q000150:complications*; D011300:Preoperative Care
D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone; D005045:Etomidate