[Clinical study in epidural injection with lappaconitine compound for post-operative analgesia].
In this study, the effect and side-effect of epidural injection with lappaconitine compound for post-operative analgesia was observed. One hundred and twenty patients were randomly divided into 4 groups. Lappaconitine compound (LB) consisted of 12 mg of lappaconitine and 22.5 mg of bupivacaine, was given to group A (the group of observation), and lappaconitine 12 mg, bupivacaine 22.5 mg and morphine 2 mg to group B, C and D respectively for control. All were given by epidural injection with single blind method during post-operative pain of incision operation. Result showed that the initiating of analgesia was quicker in group A and C than that in group B and D, and the efficacy was group D > A > C > B. There was significant difference between group A and B in the above two parameters, P < 0.01 and P < 0.05. The analgisia maintenence time of single injection was D > A > B > C, that of group D was significantly longer than that of group A (P < 0.01). It indicated that the epidural injection with LB was more rapid and potent than that with lappaconitine alone in post-operative analgesia, and the former had no side-effect, it was safer than morphine.
Chen
M G
MG
Affiliated People's Hospital, Fujian College of TCM, Fuzhou.
Wang
Q H
QH
Lin
W
W
D000157:Aconitine / Q000031:analogs & derivatives*; D000328:Adult; D018712:Analgesics, Non-Narcotic; D000767:Anesthesia, Epidural; D000779:Anesthetics, Local; D002045:Bupivacaine; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007268:Injections, Epidural; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy*; D016037:Single-Blind Method
D018712:Analgesics, Non-Narcotic; D000779:Anesthetics, Local; D004338:Drug Combinations; D000157:Aconitine; C022150:lappaconitine; D002045:Bupivacaine