A mathematical approach to cytoskeletal assembly.
The cytoskeleton is a fundamental and important part of cell's structure, and is known to play a large role in controlling the shape, function, division, and motility of the cell. In recent years, the traditional biological and biophysical experimental work on the cytoskeleton has been enhanced by a variety of theoretical, physical and mathematical approaches. Many of these approaches have been developed in the traditional frameworks of physicochemical and statistical mechanics or equilibrium thermodynamic principles. An alternative is to use kinetic modelling and couch the analysis in terms of differential equations which describe mean field properties of cytoskeletal networks or assemblies. This paper describes two such recent efforts. In the first part of the paper, a summary of work on the kinetics of polymerization, fragmentation, and dynamics of actin and polymers in the presence of gelsolin (which nulceates, fragments, and caps the filaments) is given. In the second part, some of the kinetic models aimed at elucidating the spatio-angular density distribution of actin filaments interacting via crosslinks is described. This model given insight into effects that govern the formation of clusters and bundles of actin filaments, and their spatial distribution.
Department of Mathematics, University of British Columbia, Vancouver, Canada. keshet@math.ubc.ca
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Edelstein-Keshet
D000199:Actins / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D055592:Biophysical Phenomena; D001703:Biophysics; D001704:Biopolymers / Q000737:chemistry / Q000378:metabolism; D003599:Cytoskeleton / Q000737:chemistry* / Q000378:metabolism*; D018260:Gelsolin / Q000737:chemistry / Q000378:metabolism; D066298:In Vitro Techniques; D007700:Kinetics; D046911:Macromolecular Substances; D008433:Mathematics; D008954:Models, Biological; D011485:Protein Binding
D000199:Actins; D001704:Biopolymers; D018260:Gelsolin; D046911:Macromolecular Substances