Cytokines in multiple sclerosis: pro-inflammation or pro-remyelination?
The targets of the inflammatory response in multiple sclerosis (MS) are myelin and the myelin producing cells, oligodendrocytes. The infiltration of activated immune cells and recruitment of endogenous glia lead to the destruction of myelin and oligodendrocytes, a process that is compounded by the release of cytokines by infiltrating cells. Recent evidence suggests that key cytokines that are responsible for the destruction of myelin may also mediate the process of remyelination and repair. It appears that both inflammatory and repair processes are governed by the temporal and spatial relation of cytokines to their targets.
Sharief
M K
MK
Department of Neurology, UMDS, Guy's Hospital, London, England.
D016207:Cytokines / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D007378:Interleukins / Q000502:physiology; D009103:Multiple Sclerosis / Q000503:physiopathology*; D009186:Myelin Sheath / Q000502:physiology*; D009416:Nerve Regeneration / Q000502:physiology*; D009836:Oligodendroglia / Q000502:physiology*; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D016207:Cytokines; D007378:Interleukins; D014409:Tumor Necrosis Factor-alpha