Use of coreceptors other than CCR5 by non-syncytium-inducing adult and pediatric isolates of human immunodeficiency virus type 1 is rare in vitro.
We have tested a panel of pediatric and adult human immunodeficiency virus type 1 (HIV-1) primary isolates for the ability to employ the following proteins as coreceptors during viral entry: CCR1, CCR2b, CCR3, CCR4, CCR5, CCR8, CXCR4, Bonzo, BOB, GPR1, V28, US28, and APJ. Most non-syncytium-inducing isolates could utilize only CCR5. All syncytium-inducing viruses used CXCR4, some also employed V28, and one (DH123) used CCR8 and APJ as well. A longitudinal series of HIV-1 subtype B isolates from an infected infant and its mother utilized Bonzo efficiently, as well as CCR5. The maternal isolates, which were syncytium inducing, also used CXCR4, CCR8, V28, and APJ.
Aaron Diamond AIDS Research Center, The Rockefeller University, New York University School of Medicine, New York, New York 10016, USA.
Y J
YJ
Zhang
T
T
Dragic
Y
Y
Cao
L
L
Kostrikis
D S
DS
Kwon
D R
DR
Littman
V N
VN
KewalRamani
J P
JP
Moore
D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000821:virology; D002460:Cell Line; D005260:Female; D015752:Genes, env; D005816:Genetic Complementation Test; D015658:HIV Infections / Q000635:transmission / Q000821:virology*; D015497:HIV-1 / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology*; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D011247:Pregnancy; D019713:Receptors, CCR5 / Q000235:genetics / Q000502:physiology*; D019718:Receptors, CXCR4 / Q000235:genetics / Q000502:physiology; D015728:Receptors, HIV / Q000235:genetics / Q000502:physiology*; D014162:Transfection; D014779:Virus Replication
D019713:Receptors, CCR5; D019718:Receptors, CXCR4; D015728:Receptors, HIV