Transcriptional control: repression by local chromatin modification.
It is becoming increasingly clear that chromatin modification plays a fundamental part in transcriptional control. Recent studies provide new insights into how transcriptional repressors, in addition to blocking activators, may recruit repression complexes that include chromatin modification factors.
Program in Molecular Medicine, University of Massachusetts Medical Center, Worcester 01605, USA.
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D000429:Alcohol Oxidoreductases; D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D002453:Cell Cycle / Q000502:physiology; D002843:Chromatin / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D002868:Chromosomal Proteins, Non-Histone; D018899:CpG Islands; D019175:DNA Methylation; D004268:DNA-Binding Proteins / Q000502:physiology*; D004331:Drosophila melanogaster / Q000235:genetics / Q000502:physiology; D005786:Gene Expression Regulation / Q000502:physiology*; D006655:Histone Deacetylases; D006801:Humans; D051783:Methyl-CpG-Binding Protein 2; D008957:Models, Genetic; D010750:Phosphoproteins / Q000502:physiology; D011506:Proteins / Q000502:physiology; D012097:Repressor Proteins / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic / Q000502:physiology*; D016335:Zinc Fingers / Q000502:physiology
D000429:Alcohol Oxidoreductases; D051792:Basic Helix-Loop-Helix Proteins; D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D006655:Histone Deacetylases; D051783:Methyl-CpG-Binding Protein 2; D010750:Phosphoproteins; D011506:Proteins; D012097:Repressor Proteins; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; C497392:MECP2 protein, human; C489689:MeCP1 histone deacetylase complex, human; C071731:SIN3 protein, S cerevisiae; C091023:gro protein, Drosophila; C096794:C-terminal binding protein