Effect of trace element combination on the immune response of rats treated with cytostatic drug.
The effect of trace element combination, Béres Drop Plus (BDP) on the immune response of rats following single treatment with cytostatic drug (5-fluorouracil, 5-FU) was tested. Animals were treated with 5-FU and SRBC simultaneously, but separately. Rats were pretreated with BDP for 21 days. The body and spleen weight, furthermore the number of spleen cells and antibody producing cells were determined. The antibody titres in blood serum were also measured. The immune system of rats, 5 days following the 5-FU treatment, showed considerable regeneration. Pretreatment of rats with BDP had a beneficial effect on all parameters investigated.
Elekes
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Frédéric Joliot-Curie National Research Institute for Radiobiology and Radiohygiene, Budapest, Hungary.
Bertók
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D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D004338:Drug Combinations; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D005472:Fluorouracil / Q000494:pharmacology*; D007114:Immunization; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008903:Minerals; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012756:Sheep; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D014131:Trace Elements / Q000494:pharmacology*; D015032:Zinc / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D004338:Drug Combinations; D007166:Immunosuppressive Agents; D008903:Minerals; D014131:Trace Elements; C099452:mineral acids, trace elements, water, drug combination; D015032:Zinc; D005472:Fluorouracil