[A rare cause of intra-alveolar hemorrhage: a transfusion-related incident with leukoagglutination due to antigranulocyte antibodies (Trali syndrome)].
BACKGROUND
Transfusion-related acute lung injury (TRALI) is an infrequent but life-threatening complication of hemotherapy, usually secondary to passive transfer of antibody from the donor's plasma to the recipient. TRALI is a diagnosis of exclusion often masked by underlying factors.


METHODS
We report a new case of TRALI in a patient with severe multinevritis associated with Sjögren's syndrome and cryoglobulinemia, who had received intravenous immunoglobulins.


CONCLUSIONS
This case report underlines the difficulty to establish a diagnosis in both acute respiratory failure and intra-alveolar hemorrhage in patients with auto-immune disorders. This case report also emphasizes the necessity of taking precautions in these immunocompromised patients in whom hemoglobin transfusion is required.
Département de médecine interne, Hôpital de Boisguillaume, CHU, Rouen, France.
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N
Cailleux
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H
Lévesque
D
D
Bastit
A
A
Cuvelier
J F
JF
Muir
H
H
Courtois
D000368:Aged; D000906:Antibodies / Q000009:adverse effects*; D003449:Cryoglobulinemia / Q000628:therapy; D004903:Erythrocyte Aggregation / Q000209:etiology; D017707:Erythrocyte Transfusion / Q000009:adverse effects*; D005260:Female; D006098:Granulocytes / Q000276:immunology*; D006469:Hemoptysis / Q000209:etiology*; D006801:Humans; D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D011115:Polyneuropathies / Q000628:therapy; D011650:Pulmonary Alveoli / Q000473:pathology*; D012128:Respiratory Distress Syndrome / Q000209:etiology*; D012859:Sjogren's Syndrome / Q000628:therapy
D000906:Antibodies; D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains; D016756:Immunoglobulins, Intravenous
Une cause rare d'hémorragie intra-alvéolaire: l'accident transfusionnel avec leucoagglutination par anticorps antigranuleux (syndrome Trali).