Numerical analysis of thermal denaturation of nucleic acids.
Denaturation of DNA molecules by stepwise incrementation of the temperature leads to melting profiles showing a fine structure, composed of individual melting modes. A method is described by which quantitative physical information brought by the modes can be extracted from the melting profile. Related problems such as data editing and smoothing are also discussed.
Gabarro
J
J
Fondation Curie-Institut Du Radium, Section de Biologie, Laboratoire 112, Orsay, France.
D004247:DNA / Q000737:chemistry; D003627:Data Interpretation, Statistical; D006358:Hot Temperature; D008956:Models, Chemical; D009691:Nucleic Acid Denaturation; D013696:Temperature
D004247:DNA