NPY Y1 receptors in the dorsal periaqueductal gray matter regulate anxiety in the social interaction test.
We have reported previously that the NPY Y1 receptor antagonist BIBP3226 applied into the dorsal periaqueductal gray matter (DPAG) has an anxiogenic-like effect in the elevated plus-maze test in rats. In the present study the effects of neuropeptide Y (NPY) Y1 receptor antagonists BIBP3226 (500 pmol) and 1229U91 (formerly also GR231118, GW1229 and EXBP68, 100 and 500 pmol) administered into the DPAG were investigated in the social interaction test in rats. BIBP3226 and 1229U91 (both 500 pmol) significantly decreased the time spent in active social interaction. These results provide additional evidence that NPY-ergic neurotransmission in the DPAG may be involved in the modulation of anxiety-related behaviour and suggest that endogenous NPY, released under stressful conditions in the DPAG, relieves anxiety via the NPY Y1 receptors. This is the first report demonstrating the effect of NPY receptor active agent on social behaviour.
Department of Pharmacology, Faculty of Medicine, University of Tartu, Estonia.
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Kask
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Rägo
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Harro
D000818:Animals; D001007:Anxiety / Q000523:psychology*; D001120:Arginine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D007398:Interpersonal Relations; D008297:Male; D008636:Mesencephalon / Q000502:physiology; D008845:Microinjections; D010456:Peptides, Cyclic / Q000008:administration & dosage / Q000494:pharmacology; D010487:Periaqueductal Gray / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D017476:Receptors, Neuropeptide Y / Q000037:antagonists & inhibitors / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology
C097287:1229U91; C092926:BIBP 3226; D010456:Peptides, Cyclic; D017476:Receptors, Neuropeptide Y; C097212:neuropeptide Y-Y1 receptor; D001120:Arginine