Segment-based scores for pairwise and multiple sequence alignments.
In this paper, we discuss a novel scoring scheme for sequence alignments. The score of an alignment is defined as the sum of so-called weights of aligned segment pairs. A simple modification of the weight function used by the original version of the DIALIGN alignment program turns out to have a crucial advantage: it can be applied to both, global and local alignment problems without the need to specify a threshold parameter.
GSF-National Research Center for Environment and Health, Institute of Biomathematics and Biometry, Neuherberg, Germany. morgenstern@gsf.de
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Morgenstern
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Atchley
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Hahn
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Dress
D000595:Amino Acid Sequence; D000818:Animals; D001185:Artificial Intelligence; D006801:Humans; D008969:Molecular Sequence Data; D011506:Proteins / Q000737:chemistry / Q000235:genetics; D016415:Sequence Alignment / Q000379:methods* / Q000706:statistics & numerical data; D017386:Sequence Homology, Amino Acid; D012984:Software
D011506:Proteins