Anchoring of c-myc on nuclear matrix proteins in process of mouse thymic T lymphocyte proliferation induced by ConA.
Isolation and characterization of functional nuclear matrix proteins involved in DNA anchoring and gene expression is one of the major subjects of current nuclear matrix research. Southwestern blotting (DNA-protein hybridization) was applied to studying the anchoring of c-myc on the nuclear matrix proteins in mouse thymic T lymphocytes. The results showed that c-myc bound to the lamin, p34 and p36 nuclear matrix proteins specifically. In the process of mouse thymic PNA-T lymphocytes proliferation induced by ConA, the anchoring of c-myc on p34 and p36 nuclear matrix proteins changed dynamically.
Zeng
C
C
Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Cai
S
S
Zhou
F
F
Zhang
J
J
Wang
P
P
D000818:Animals; D034961:Antigens, Nuclear; D001324:Autoantigens / Q000235:genetics*; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D016259:Genes, myc; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D009687:Nuclear Proteins / Q000235:genetics*; D013601:T-Lymphocytes / Q000276:immunology*
D034961:Antigens, Nuclear; D001324:Autoantigens; D009687:Nuclear Proteins; D003208:Concanavalin A