Changes in uterine artery doppler velocimetry in pregnant patients undergoing glucose tolerance test may predict adverse outcome in later pregnancy: a preliminary study.
OBJECTIVE
Previous studies have demonstrated that high glucose levels often cause increased placental resistance to blood flow. The present study was undertaken to assess whether any changes in placental vascular resistance would occur following a standard glucose tolerance test.


METHODS
Doppler velocimetry of uterine, intraplacental and umbilical vessels was performed before and after administration of glucose tolerance test.


RESULTS
The uterine circulation demonstrated abnormal indices in patients that later developed placental insufficiency.


CONCLUSIONS
This preliminary study demonstrated that following a glucose tolerance test significant changes seem to occur in the uteroplacental but not in the fetoplacental circulation of pregnancies destined to develop preeclampsia or intrauterine growth restriction.
Jaffe
R
R
Department of Obstetrics and Gynecology, Columbia-Presbyterian Medical Center, New York, N.Y., USA.
Friedman
Z
Z
D001158:Arteries; D005260:Female; D005865:Gestational Age; D005951:Glucose Tolerance Test; D006801:Humans; D017078:Laser-Doppler Flowmetry; D010927:Placental Insufficiency / Q000175:diagnosis; D011247:Pregnancy; D014599:Uterus / Q000098:blood supply*; D014655:Vascular Resistance