[The central mechanism of corticoids in the incidence of stress-induced hypertension].
We observed that in rats during the incidence of hypertension induced by stress, an increase in the plasma concentrations of catecholamines, corticosterone, glucose and lipids is parallel with an elevation of blood pressure and heart rate. Microinjection of corticoids into the rVLM elicits an effect of pressor, tachycardia and enhancement of pressor response to stimulation of the defense area, this may be one of the important causes in the incidence of stress-induced hypertension. This effect is taken place by a rapid membrane effect of the corticoids on the cardiovascular neurons in the rVLM, which is related to an abnormal enhancement of cholinergic activity and activation of calcium channel. Whereas NO plays an inhibitory effect on the cardiovascular neurons in the rVLM.
Department of Physiology, Shanghai Medical University.
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D000305:Adrenal Cortex Hormones / Q000494:pharmacology / Q000502:physiology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002395:Catecholamines / Q000097:blood*; D003345:Corticosterone / Q000097:blood; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000097:blood* / Q000209:etiology; D008526:Medulla Oblongata / Q000187:drug effects; D051381:Rats; D013315:Stress, Psychological / Q000150:complications*
D000305:Adrenal Cortex Hormones; D002395:Catecholamines; D003345:Corticosterone