[The enzymatic activity of IgG preparations in viral hepatitis].
The activity of the enzymatic activity of the preparations of IgG1, IgG2 and IgG4, isolated from the blood of patients with acute virus hepatitis B and chronic viral hepatitis C resulting in cirrhosis, was studied. The blood samples were found to have DNAase activity significantly exceeding that of immunoglobulins isolated from the blood sera of healthy donors, as well as peroxidase, oxidase and esterase activities, whose level did not significantly differ from those of the donor blood sera. The interaction of IgG preparations with the cations of different metals was studied. The study revealed that the addition of CuSO4 solution at the final concentration of 4.7 x 10(-5) M to the blood samples led to a significant increase in activity in comparison with the initial one (on the average, 7.8 +/- 2.97 times) in all 14 samples. The activity thus observed was partially inhibited by the addition of the solution of staphylococcal protein A. As noted in the course of this study, high DNAase and peroxidase activities of Ig were most frequently observed in patients with cirrhosis of the liver. The difference in the levels of IgG activity between patients with cirrhosis of the liver and patients with virus hepatitis, but no signs of cirrhosis, is not significant.
Zhil'tsov
I V
IV
Medical Institute, Vitebsk, Belarus.
Generalov
I I
II
Dotsenko
M L
ML
Matveev
A A
AA
D000208:Acute Disease; D000328:Adult; D001327:Autoimmune Diseases / Q000201:enzymology* / Q000276:immunology; D003851:Deoxyribonucleases / Q000097:blood; D004950:Esterases / Q000097:blood; D005260:Female; D006509:Hepatitis B / Q000201:enzymology* / Q000276:immunology; D019694:Hepatitis B, Chronic / Q000201:enzymology* / Q000276:immunology; D019698:Hepatitis C, Chronic / Q000201:enzymology* / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008103:Liver Cirrhosis / Q000201:enzymology / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010544:Peroxidases / Q000097:blood
D007074:Immunoglobulin G; D010544:Peroxidases; D003851:Deoxyribonucleases; D004950:Esterases
Fermentativnaia aktivnost' preparatov IgG pri virusnykh gepatitakh.