Synthesis and pharmacological properties of some quinoline derivatives.
A series of 2-(2-thienyl) cinchoninic acids 3, their derivatives 5 and 4-(3-substituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazolo-6-yl)-2-( 2-thienyl) quinolines 6 were synthesized. The structures of the newly synthesized compounds are confirmed by analytical, IR, NMR and mass spectral data. The newly synthesized compounds were evaluated for their anti-inflammatory, analgesic and anthelmintic activity. The results indicated that dinitrothiophene derivatives 5 are more active.
Department of Studies in Chemistry, Mangalore University, Karnataka State, India. root@mnglr-ernet.in
B
B
Kalluraya
S
S
Sreenivasa
D000700:Analgesics / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000871:Anthelmintics / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013057:Spectrum Analysis
D000700:Analgesics; D000871:Anthelmintics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D011804:Quinolines