[Transcriptional regulation by CREB and proteins of CREB family].
CREB (cAMP-responsive element binding protein), which can be activated after phosphorylation by protein kinase A, plays an important role in cAMP-induced gene expression. Several recent studies have suggested that a co-activator designated as CREB binding protein (CBP) is crucial in mediating the transcriptional activity of CREB. In nervous system, in addition to playing a role in neurotransmitter-induced gene transcription, CREB may take part in mediating neurotrophin signals that ultimately lead to such cellular responses as proliferation, differentiation and survival.
Tian
J H
JH
Beijing Medical University.
Wang
X M
XM
Han
J S
JS
D051697:Activating Transcription Factor 1; D051698:Activating Transcription Factor 2; D000818:Animals; D051786:Cyclic AMP Response Element Modulator; D017362:Cyclic AMP Response Element-Binding Protein / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics; D012097:Repressor Proteins; D014157:Transcription Factors / Q000235:genetics*; D014158:Transcription, Genetic
D051697:Activating Transcription Factor 1; D051698:Activating Transcription Factor 2; D017362:Cyclic AMP Response Element-Binding Protein; D004268:DNA-Binding Proteins; D012097:Repressor Proteins; D014157:Transcription Factors; D051786:Cyclic AMP Response Element Modulator