Syntheses of trans-5-oxo-hexahydro-pyrrolo[3,2-b]pyrroles and trans-5-oxo-hexahydro-furo[3,2-b]pyrroles (pyrrolidine trans-lactams and trans-lactones): new pharmacophores for elastase inhibition.
Enzyme Chemistry 2, Development Chemistry 3, Physical Sciences, and Enzyme Pharmacology, GlaxoWellcome Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
S J
SJ
Macdonald
D J
DJ
Belton
D M
DM
Buckley
J E
JE
Spooner
M S
MS
Anson
L A
LA
Harrison
K
K
Mills
R J
RJ
Upton
M D
MD
Dowle
R A
RA
Smith
C R
CR
Molloy
C
C
Risley
D001384:Azetidines / Q000494:pharmacology; D006801:Humans; D007769:Lactams / Q000138:chemical synthesis* / Q000494:pharmacology; D007783:Lactones / Q000138:chemical synthesis* / Q000494:pharmacology; D019272:Leukocyte Elastase / Q000037:antagonists & inhibitors*; D009504:Neutrophils / Q000201:enzymology*; D010879:Piperazines / Q000494:pharmacology; D015842:Serine Proteinase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D001384:Azetidines; D007769:Lactams; D007783:Lactones; D010879:Piperazines; D015842:Serine Proteinase Inhibitors; C105999:DMP 777; D019272:Leukocyte Elastase