[Transferability of tazobactam/piperacillin (TAZ/PIPC) to cerebrospinal fluid of rabbit with meningitis caused by Staphylococcus aureus].
The transferability of tazobactam/piperacillin (TAZ/PIPC) to cerebrospinal fluid (CSF) was studied employing rabbits with experimental meningitis caused by Staphylococcus aureus. 125 or 250 mg/kg of TAZ/PIPC was intravenously administered to rabbits with experimental meningitis then concentrations of TAZ and PIPC in CSF and serum were measured. In the group to which 125 mg/kg of TAZ/PIPC was administered, mean concentration of TAZ in CSF was 7.3 and 2.4 micrograms/ml at 30 and 60 min after administration, respectively, and concerning PIPC, it was 10.1 and 3.5 micrograms/ml, respectively. CSF/serum ratio of TAZ was 29.4% and 31.4%, respectively, and that of PIPC was 24.3 and 35.6%, respectively. In the group to which 250 mg/kg of TAZ/PIPC was administered, mean concentration of TAZ in CSF was 16.5 and 12.6% micrograms/ml, respectively, and concerning PIPC, it was 25.6 and 18.2 micrograms/ml, respectively. CSF/serum ratio of TAZ was 22.1 and 56.1%, respectively, and that of PIPC was 12.2 and 51.9%, respectively. Addition of TAZ did not make significant change of transferability of PIPC to CSF. Considering the antibacterial effect of TAZ/PIPC against main causative organism of meningitis, this agent was thought to be effective for the treatment of purulent meningitis.
Haruta
T
T
Department of Pediatrics, Kobe City General Hospital.
Nishio
T
T
Kobayashi
Y
Y
D000818:Animals; D004359:Drug Therapy, Combination / Q000097:blood / Q000134:cerebrospinal fluid*; D004791:Enzyme Inhibitors / Q000134:cerebrospinal fluid; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid* / Q000188:drug therapy; D010397:Penicillanic Acid / Q000031:analogs & derivatives / Q000097:blood / Q000134:cerebrospinal fluid; D010406:Penicillins / Q000134:cerebrospinal fluid; D010878:Piperacillin / Q000097:blood / Q000134:cerebrospinal fluid; D000077725:Piperacillin, Tazobactam Drug Combination; D011817:Rabbits; D013203:Staphylococcal Infections / Q000134:cerebrospinal fluid* / Q000188:drug therapy; D000078142:Tazobactam; D013997:Time Factors; D065093:beta-Lactamase Inhibitors
D004791:Enzyme Inhibitors; D010406:Penicillins; D065093:beta-Lactamase Inhibitors; D000077725:Piperacillin, Tazobactam Drug Combination; D010397:Penicillanic Acid; D000078142:Tazobactam; D010878:Piperacillin