[Blood pressure responses to cold pressor stress and its relation to sodium metabolism in salt-sensitive children].
OBJECTIVE
To investigate the blood pressure responses to cold pressor stress and its relation to sodium metabolism in salt-sensitive children.


METHODS
268 children aged 10.6 +/- 1.1 years were detected salt-sensitivity with the tests of oral saline load and furosemde sodium-volume depletion. Cold pressor stress test, sodium metabolism, and the related factors were measured.


RESULTS
25% of the children were detected to be salt-sensitive. The increased extent of blood pressure and its recovery time from peak to baseline in salt-sensitive children were significantly higher than those in non-salt-sensitive children during the cold pressor stress test (t = 5.14, 3.94, P < 0.01 and t = 2.16, P < 0.05). The increased extent of blood pressure and its recovery time during cold pressor test were correlated positively with red-cell sodium content, and were correlated negatively with 2 hour urinary sodium excreation during the oral saline load test.


CONCLUSIONS
Children with salt-sensitivity have a remarkably increased blood pressure responses to cold pressor stress (sympathetic activity), which is related with abnormal sodium metabolism.
First Affiliated Hospital, Xian Medical University.
J
J
Mu
Z
Z
Liu
J
J
Yang
D001794:Blood Pressure / Q000502:physiology*; D002648:Child; D003080:Cold Temperature; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology; D008297:Male; D011311:Pressoreceptors / Q000502:physiology; D012964:Sodium / Q000378:metabolism*; D013312:Stress, Physiological / Q000503:physiopathology*
D012964:Sodium