From slowly progressive amnesic syndrome to rapidly progressive Alzheimer disease.
A 57-year-old woman had a neuropsychologically documented 5-year history of a slowly progressive amnesic syndrome followed by a 1-year history of rapidly progressive dementia. There was no family history of dementia. Magnetic resonance imaging failed to show a structural basis, electroencephalography failed to show changes of Creutzfeldt-Jakob disease, and cerebrospinal fluid examination was normal. A diagnosis of Alzheimer disease was confirmed by brain biopsy. The abrupt change in disease course was unique but suggested probable overlap between posited subtypes of Alzheimer disease.
Caselli
R J
RJ
Department of Neurology, Mayo Clinic, Scottsdale, Arizona 85259, USA.
Couce
M E
ME
Osborne
D
D
Deen
H G
HG
Parisi
J P
JP
D000544:Alzheimer Disease / Q000175:diagnosis* / Q000523:psychology; D000647:Amnesia / Q000175:diagnosis* / Q000523:psychology; D001921:Brain / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009483:Neuropsychological Tests; D013577:Syndrome