Retroviral transfer of antisense sequences results in reduction of C-Abl and induction of apoptosis in hemopoietic cells.
Daniel
R
R
Fels Institute for Cancer Research and Molecular Biology, Departments of Pathology and Laboratory Medicine, Biochemistry, Microbiology and Immunology, Temple University School of Medicine, Philadelphia, Pa., USA.
Chung
S
S
Chen
H
H
Wong
P M
PM
D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D002455:Cell Division; D002460:Cell Line; D016373:DNA, Antisense; D018014:Gene Transfer Techniques; D016313:Genes, abl / Q000502:physiology*; D005822:Genetic Vectors; D006133:Growth Substances / Q000494:pharmacology; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D008214:Lymphocytes / Q000166:cytology*; D051379:Mice; D016315:Proto-Oncogene Proteins c-abl / Q000032:analysis; D016372:RNA, Antisense / Q000032:analysis; D012333:RNA, Messenger / Q000032:analysis; D016185:Receptors, Interleukin-3 / Q000235:genetics; D012190:Retroviridae / Q000235:genetics; D015854:Up-Regulation
D016373:DNA, Antisense; D006133:Growth Substances; D016372:RNA, Antisense; D012333:RNA, Messenger; D016185:Receptors, Interleukin-3; D016315:Proto-Oncogene Proteins c-abl