Congenital diabetes in an infant with trisomy 21.
A newborn infant with trisomy 21 was found to have congenital diabetes which appears to be permanent. Congenital diabetes is extremely rare and differs from type I or type II diabetes. It has never been reported previously in Down's syndrome and it seems to be due to a selective beta cell defect with undetectable C-peptide but normal alpha-cell function.
Shehadeh
N
N
Juvenile Diabetes Unit, Rambam Medical Center, Haifa, Israel.
Gershoni-Baruch
R
R
Etzioni
A
A
D003922:Diabetes Mellitus, Type 1 / Q000151:congenital / Q000235:genetics*; D004314:Down Syndrome; D006801:Humans; D007231:Infant, Newborn; D008297:Male