[In vivo resistance to strains of Trypanosoma rhodesiense, Mozambique, 1985].
We report the existence of high resistance to Melarsoprol and low resistance to Suramin in 11 Trypanosoma rhodesiense species. They were isolated from humans in the Tete province, Mozambique, and kept in mice at the Maputo National Health Institute. The preliminary results obtained with Suramin administered intracranially, are also reported.
Instituto Nacional de Salud, Maputo, Mozambique.
O
O
Pérez Martín
M
M
Lastre González
M
M
Urban
J
J
Shwalbach
D000818:Animals; D004351:Drug Resistance; D006801:Humans; D008549:Melarsoprol / Q000494:pharmacology* / Q000627:therapeutic use; D051379:Mice; D013498:Suramin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014344:Trypanocidal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D016833:Trypanosoma brucei rhodesiense / Q000187:drug effects*; D014353:Trypanosomiasis, African / Q000188:drug therapy* / Q000469:parasitology
D014344:Trypanocidal Agents; D013498:Suramin; D008549:Melarsoprol
Resistencia in vivo de estirpes de Trypanosoma rhodesiense, Mozambique, 1985.