A possible role for soluble IL-6 receptor in the pathogenesis of systemic onset juvenile chronic arthritis.
Investigation of the agonist and two antagonists to interleukin 6 (IL-6) and their possible role in the pathogenesis of different sub-groups of juvenile chronic arthritis (JCA). Sera of 54 patients and 10 age-matched controls were tested: 20 with pauci-articular JCA, 12 with polyarticular JCA, and 22 systemic JCA. Interleukin 6, soluble interleukin 6 receptor (agonist), soluble gp130 and autoantibodies to IL-6 (antagonist to IL-6) were measured, as well as C-reactive protein as an indicator of disease activity. In addition, during fever two systemic JCA patients were analysed longitudinally for these parameters. There was a significant increase in soluble IL-6 receptor (sIL-6R) concentrations. No difference in the levels of soluble gp130 and autoantibodies to IL-6 in the systemic JCA group was found. In two patients the fever curves corresponded to the IL-6 levels measured. sIL-6R serum concentrations also showed a tendency to follow the fever. The authors have shown that in systemic JCA, the levels of sIL-6R, agonist of IL-6, were increased significantly compared to the other groups, while levels of antagonists to IL-6 were not changed in the face of increased levels of IL-6 in systemic JCA. These results suggest an imbalance of IL-6 homeostasis.
Keul
R
R
Department of Biochemistry, Klinikum Pauwelsstrasse 30, D-52057 Aachen, Germany.
Heinrich
P C
PC
Müller-newen
G
G
Muller
K
K
Woo
P
P
D001171:Arthritis, Juvenile / Q000097:blood / Q000145:classification / Q000209:etiology* / Q000503:physiopathology; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D001327:Autoimmune Diseases / Q000097:blood / Q000145:classification / Q000209:etiology* / Q000503:physiopathology; D015415:Biomarkers; D005334:Fever / Q000097:blood / Q000209:etiology; D006706:Homeostasis; D006801:Humans; D015850:Interleukin-6 / Q000097:blood / Q000276:immunology*; D019947:Receptors, Interleukin-6 / Q000502:physiology*; D012995:Solubility
D001323:Autoantibodies; D015415:Biomarkers; D015850:Interleukin-6; D019947:Receptors, Interleukin-6