Mycobacterium bovis osteomyelitis involving a hip arthroplasty after intravesicular bacille Calmette-Guérin for bladder cancer.
Bacille Calmette-Guérin (BCG), an attenuated strain of Mycobacterium bovis, is one of the most effective agents in the treatment of superficial bladder cancer. BCG osteomyelitis is an infrequent complication of intravesicular BCG therapy; only five cases of BCG vertebral osteomyelitis have been reported in the literature. Similarly, the infection of an indwelling extravascular device by BCG is rare; there is only one previous report documenting infection associated with an automated implantable cardiac defibrillator. We report a case of BCG osteomyelitis involving a hip arthroplasty that occurred after intravesicular administration of BCG for bladder cancer, and we review the risk factors predisposing to such infections and their treatment.
Department of Medicine, Infectious Diseases, University of Rochester School of Medicine and Dentistry, New York 14642, USA.
C E
CE
Guerra
R F
RF
Betts
R J
RJ
O'Keefe
J W
JW
Shilling
D000283:Administration, Intravesical; D000368:Aged; D019644:Arthroplasty, Replacement, Hip; D001500:BCG Vaccine / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009164:Mycobacterium Infections / Q000209:etiology* / Q000276:immunology; D009163:Mycobacterium bovis / Q000276:immunology; D010019:Osteomyelitis / Q000209:etiology* / Q000276:immunology; D011183:Postoperative Complications; D001749:Urinary Bladder Neoplasms / Q000150:complications* / Q000628:therapy
D001500:BCG Vaccine