The integration of medicinal chemistry, drug metabolism, and pharmaceutical research and development in drug discovery and development. The story of Crixivan, an HIV protease inhibitor.
Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, USA.
J H
JH
Lin
D
D
Ostovic
J P
JP
Vacca
D000818:Animals; D015195:Drug Design; D017320:HIV Protease Inhibitors / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D019469:Indinavir / Q000737:chemistry / Q000378:metabolism*; D007408:Intestinal Absorption; D012995:Solubility
D017320:HIV Protease Inhibitors; D019469:Indinavir