The epidemiology of Haemophilus influenzae type b carriage among infants and young children in Santo Domingo, Dominican Republic.
BACKGROUND
Whether herd immunity will occur with widespread Haemophilus influenzae type b (Hib) vaccination in developing countries is dependent on whether the vaccines are capable of reducing carriage in these settings. However, few population-based studies of Hib carriage in developing countries exist.


METHODS
To study Hib carriage in the Dominican Republic, we collected nasopharyngeal swab specimens from a population-based sample of 983 children 0 to 47 months old in a periurban area of Santo Domingo.


RESULTS
Nasopharyngeal swabs of 76 (7.7%) children were positive for Hib. Hib carriage varied by age group with a low of 1.5% among 0 to 5 month olds, a peak of 12.5% in 6 to 11 month olds and prevalence rates of 6.0, 7.9 and 9.8% among 1-, 2- and 3-year-olds, respectively. Hib carriage was 51% lower among currently breast-fed 6 to 11 month olds than among those not currently breast-fed (18.2% vs. 9.0%; P=0.08).


CONCLUSIONS
Infants and young children in Santo Domingo have high rates of Hib carriage, characterized by an early peak in carriage that corresponds with the peak of risk for Hib meningitis. The ability of Hib vaccines to diminish carriage to levels that will effectively reduce transmission and lead to herd immunity in this setting needs to be determined.
Departmento Nacional de Epidemiologia, Secretaria ed Estado de Salud Publica y Asistencia Social, Santo Domingo, Dominican Republic.
E
E
Gómez
A
A
Moore
J
J
Sánchez
J
J
Kool
P L
PL
Castellanos
J M
JM
Feris
M
M
Kolczak
O S
OS
Levine
D002353:Carrier State / Q000453:epidemiology*; D002675:Child, Preschool; D003906:Developing Countries; D004293:Dominican Republic / Q000453:epidemiology; D006192:Haemophilus Infections / Q000453:epidemiology*; D019741:Haemophilus influenzae type b / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D009305:Nasopharynx / Q000382:microbiology