Determinants of disease in the simian immunodeficiency virus-infected rhesus macaque: characterizing animals with low antibody responses and rapid progression.
Clinical and laboratory markers of simian immunodeficiency virus (SIV) infection were studied during the first 3 months after intravenous inoculation of rhesus macaques. Virus-binding serum antibody titres were correlated strongly with disease progression (P < 0.005) and were predictive of disease outcome by 7 weeks after inoculation. Low virus-binding serum antibody responses to SIV occurred in animals that also showed acute depletion of circulating CD20+ B cells. Acute damage to the CD4+ T cell and CD20+ B cell populations rendered some animals incapable of mounting virus-specific antibody responses and these macaques became the rapidly progressing cases comprising approximately 20-30% of infected animal cohorts.
Wisconsin Regional Primate Research Center, University of Wisconsin, Madison 53715, USA.
M
M
Dykhuizen
J L
JL
Mitchen
D C
DC
Montefiori
J
J
Thomson
L
L
Acker
H
H
Lardy
C D
CD
Pauza
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D018951:Antigens, CD20 / Q000032:analysis; D018791:CD4 Lymphocyte Count; D008253:Macaca mulatta; D016097:Simian Acquired Immunodeficiency Syndrome / Q000209:etiology / Q000276:immunology* / Q000401:mortality; D015302:Simian Immunodeficiency Virus / Q000276:immunology* / Q000472:pathogenicity
D000914:Antibodies, Viral; D018951:Antigens, CD20