Ca2+ signaling in T-lymphocytes.
Ca2+ signaling in response to antigenic stimulation is essential for proliferation of T cells and therefore is one of the important early events in T-lymphocyte signal transduction. Several aspects of T cell receptor/CD3 complex stimulated Ca2+ signaling are reviewed: generation, metabolism, function, and intracellular targets of the Ca(2+)-mobilizing second messengers inositol 1,4,5-trisphosphate and cyclic ADP-ribose, the mechanism of Ca2+ entry, and the generation of Ca2+ oscillations on the single cell level. In addition, Ca2+ signaling induced by further stimuli is discussed, including other T-lymphocyte surface receptors (e.g., CD4 or beta 1-integrins, lipids, and physical stimuli).
University of Hamburg, Dept. of Enzyme Chemistry, Germany.
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Guse
D000818:Animals; D017252:CD3 Complex / Q000276:immunology / Q000378:metabolism; D020013:Calcium Signaling / Q000187:drug effects / Q000276:immunology; D006801:Humans; D050356:Lipid Metabolism; D010812:Physical Stimulation; D011948:Receptors, Antigen, T-Cell / Q000276:immunology / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D014118:Toxins, Biological / Q000378:metabolism
D017252:CD3 Complex; D011948:Receptors, Antigen, T-Cell; D014118:Toxins, Biological