Evaluation and management of dyslipoproteinemia in children.
The major goal of the evaluation and management of DLP in children is to provide safe and effective therapy with lifestyle modification. There is a strong rationale for the initiation of DLP treatment in childhood to limit the earliest stages of atherosclerosis, to establish lifelong lifestyle changes in diet and activity, and to limit the acquisition of additional CVD risk factors such as smoking and obesity. The NCEP has recommended screening for children with a parent with total cholesterol of 240 mg/dL or greater or a parent or grandparent with onset of CVD before age 55 years. Clinical evaluation and management are based on an LDL-C level of 130 mg/dL or greater. This approach to screening has a low sensitivity to identify children with DLP. Initial therapy is with a step 1 diet followed by the step 2 diet if necessary. Medications are reserved for older children with LDL-C of 190 mg/dL or greater after diet therapy or 160 mg/dL or greater with other CVD risk factors.
Department of Pediatrics, University of Alabama at Birmingham, USA.
F A
FA
Franklin
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N
Dashti
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CC
Franklin
D000293:Adolescent; D002318:Cardiovascular Diseases / Q000517:prevention & control; D002648:Child; D008078:Cholesterol, LDL / Q000097:blood; D018752:Diet, Fat-Restricted; D015444:Exercise; D006801:Humans; D006951:Hyperlipoproteinemias / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D009765:Obesity / Q000150:complications / Q000517:prevention & control
D008078:Cholesterol, LDL