[5HT-moduline an new peptide specifically interactive with the serotonergic system: physiopathologic implications].
5-HT1B receptors play a specific role as one of the many receptors regulating serotonergic activity. This endogenous peptide was recently isolated and characterized. Specific interaction has been demonstrated. 5-HT-moduline appears to be implicated in central nervous system response to various stimuli, particularly stress. It might play an important role in adaptation/inadaptation mechanisms (stress, anxiety, depression).
Unité de Pharmacologie Neuro-immuno-endocrinienne, Institut Pasteur, Paris.
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Fillion
D000818:Animals; D006801:Humans; D001523:Mental Disorders / Q000503:physiopathology*; D009479:Neuropeptides / Q000502:physiology*; D009842:Oligopeptides / Q000502:physiology*; D044302:Receptor, Serotonin, 5-HT1B; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism; D012701:Serotonin / Q000502:physiology*; D013315:Stress, Psychological / Q000503:physiopathology
C102005:5-HT-moduline; C470302:HTR1B protein, human; D009479:Neuropeptides; D009842:Oligopeptides; D044302:Receptor, Serotonin, 5-HT1B; D011985:Receptors, Serotonin; D012701:Serotonin
La 5HT-moduline, un nouveau peptide endogène interagissant spécifiquement avec le système sérotonergique: implications physiopathologiques.