Anticonvulsant profile of Siotone granules, a herbal preparation.
Siotone granule, a herbal psychotropic formulation was tested for its effectiveness in various models of convulsions in animals. S. granule (100 and 200 mg/kg) offered significant protection against pentylenetetrazol-, maximal electroshock- and strychnine-induced convulsions. In hypoxic stress-induced convulsions only 200 mg/kg was effective. It also reduced percent mortality per se and rendered total protection when given in combination with sub-protective dose of diazepam (0.5 mg/kg) and MK-801 (0.1 mg/kg) against pentylenetetrazol-induced convulsions. The anticonvulsant action of S. granule was blocked by flumazenil (4 mg/kg) suggesting the involvement of GABAergic mechanism.
Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
S K
SK
Kulkarni
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P
Joseph
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D008515:Medicine, Ayurvedic; D051379:Mice; D051381:Rats; D017208:Rats, Wistar
D000927:Anticonvulsants