Effects of chemotherapy on osseointegration of implants: a case report.
A patient underwent mandibular resection for high-grade osteosarcoma with immediate reconstruction with a microvascular fibula free bone graft and simultaneous placement of osseointegrated implants. Following initial healing, she underwent six cycles of chemotherapy and had further revision surgery prior to implant exposure and construction of a prosthesis. The chemotherapy appears to have had no deleterious effects on implant osseointegration or survival.
University of Pacific School of Dentistry, San Francisco, Calif, USA.
A R
AR
McDonald
M A
MA
Pogrel
A
A
Sharma
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology* / Q000627:therapeutic use; D016025:Bone Transplantation / Q000379:methods; D002945:Cisplatin / Q000009:adverse effects; D003606:Dacarbazine / Q000008:administration & dosage; D017742:Dental Care for Chronically Ill; D003758:Dental Implantation, Endosseous / Q000379:methods; D015921:Dental Implants; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D005360:Fibula / Q000601:surgery; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008339:Mandibular Neoplasms / Q000188:drug therapy / Q000534:rehabilitation / Q000601:surgery*; D015080:Mesna / Q000008:administration & dosage; D016348:Osseointegration / Q000187:drug effects*; D012516:Osteosarcoma / Q000188:drug therapy / Q000534:rehabilitation / Q000601:surgery*
D015921:Dental Implants; D003606:Dacarbazine; D004317:Doxorubicin; D015080:Mesna; D002945:Cisplatin; D007069:Ifosfamide