Genetic characterization of parainfluenza virus 3 derived from guinea pigs.
To understand the relationship between novel parainfluenza virus 3 (PIV-3), which has recently been isolated from the lungs of guinea pigs, and other PIV-3 strains, we determined the complete nucleotide sequence of the novel PIV-3 (GPv) genome. A comparison of the nucleotide sequence among PIV-3s, including bovine PIV-3, revealed that GPv is closely related to human PIV-3. The results of the phylogenetic analysis clearly showed that GPv is a lineage of human PIV-3, suggesting that GPv has probably been introduced into guinea pig colonies via infected humans.
Laboratory Animal Center for Biomedical Research, Nagasaki University School of Medicine, Japan.
K
K
Ohsawa
A
A
Yamada
K
K
Takeuchi
Y
Y
Watanabe
H
H
Miyata
H
H
Sato
D000818:Animals; D002417:Cattle; D002522:Chlorocebus aethiops; D016679:Genome, Viral; D006168:Guinea Pigs; D006801:Humans; D008168:Lung / Q000821:virology*; D010802:Phylogeny; D018108:Respirovirus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D012689:Sequence Homology, Nucleic Acid; D014709:Vero Cells