A novel translocation (1;2)(p34;p21-22) in acute myelomonoblastic leukemia.
A novel and as yet unrecorded translocation, (1;2)(p34;p21-22), detected in a patient with acute myeloid leukemia (AML) is reported. The leukemia--in this case, AML-M4--showed a rapidly progressive fatal course despite an early transient response to aggressive chemotherapy. In this patient, the leukemic cells showed a novel balanced translocation, (1;2)(p34;p21-22), in most of the metaphases at the time of diagnosis and during subsequent relapse. Interferon-inducible double-stranded RNA-dependent protein kinase (ds RNA-PK) is located in the chromosome region, 2p21-22, that was involved in the translocation in this case. The possible role of ds RNA-PK in leukemogenesis is briefly mentioned.
Department of Hematology, Hadassah University Hospital, Jerusalem, Israel.
I S
IS
Lossos
V
V
Bogomolski-Yahalome
O
O
Yehuda
S
S
Ben-Neriah
D
D
Ben-Yehuda
R
R
Leizerowitz
A
A
Polliack
D000293:Adolescent; D002878:Chromosomes, Human, Pair 1; D002889:Chromosomes, Human, Pair 2; D006801:Humans; D015479:Leukemia, Myelomonocytic, Acute / Q000209:etiology / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic; D019892:eIF-2 Kinase / Q000502:physiology
D019892:eIF-2 Kinase