[Methods and monitoring of antibiotic therapy of infectious endocarditis].
Antibiotic treatment of infective endocarditis has to be discussed when the microorganism has been identified. Antibiotics must be started as soon as possible, just after blood samplings in case of clinical bacteraemia, or as soon as blood cultures are positive. In case of negative blood cultures, diagnosis of endocarditis has to be reconsidered, according to Duke's criteria, and antibiotics must not be started until there is strong evidence in favour of infective endocarditis. Antibiotic treatment must be bactericidal, intravenously administered, for a long time to sterilize vegetations. Duration of antibiotics depends on the microorganism, and whether there is a valvular prosthesis or not. Hospitalization is often mandatory, but there is a trend towards the use of outpatient treatments, only possible in some indications.
Besnier
J M
JM
Service de maladies infectieuses Hôpital Bretonneau, Tours.
Choutet
P
P
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016470:Bacteremia / Q000382:microbiology; D001419:Bacteria / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification; D004334:Drug Administration Schedule; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D006350:Heart Valve Prosthesis / Q000382:microbiology; D006760:Hospitalization; D006801:Humans; D007275:Injections, Intravenous; D013203:Staphylococcal Infections / Q000188:drug therapy; D013290:Streptococcal Infections / Q000188:drug therapy
D000900:Anti-Bacterial Agents
Modalités et surveillance de l'antibiothérapie des endocardites infectieuses.