Prognostic and diagnostic value of endogenous erythroid colony formation in essential thrombocythemia.
Endogenous erythroid colonies (EECs), a typical characteristic of polycythemia vera (PV), could be observed in essential thrombocythemia (ET). Erythroid progenitors culture carried out in 34 previously untreated patients with unequivocal ET showed EECs in 35% of the cases. During a mean follow up of 4 years after the culture, the 12 EECs(+) and the 22 EECs(-) patients did not show any difference for a thrombotic or haemorrhagic complication, and the only one patient who showed an involvement of erythropoiesis was in the EECs(-) group.
Service d'Hématologie Cytologique, Hôpital Broussais, Paris, France.
M
M
Ciaudo
J M
JM
Hadjez
I
I
Teyssandier
E
E
Coly
R
R
Zittoun
J P
JP
Marie
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001853:Bone Marrow / Q000473:pathology; D003114:Colony-Forming Units Assay; D015672:Erythroid Precursor Cells / Q000473:pathology*; D004920:Erythropoiesis; D005260:Female; D006470:Hemorrhage / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012306:Risk; D013920:Thrombocythemia, Essential / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D013923:Thromboembolism / Q000453:epidemiology / Q000209:etiology