Low frequency of HLA-B27 and scarcity of ankylosing spondylitis in a Zairean Bantu population.
Ankylosing spondylitis (AS) is an inflammatory rheumatic disease which is thought to be rarely seen in African Blacks. Its genetic predisposition has been stressed in Caucasians where the HLA-B27 antigen is firmly linked to the disease. In the present study, HLA-B27 antigen was determined in 146 individuals of Bantu root. Only one of these subjects was found to possess HLA-B27 antigen. This study correlates the low frequency of HLA-B27 with the observed scarcity of AS in patients attending a clinic in Kinshasa for osteoarticular diseases.
Mbayo
K
K
Cliniques Universitaires de Kinshasa, Zaïre.
Mbuyi-Muamba
J M
JM
Lurhuma
A Z
AZ
Halle
L
L
Kaplan
C
C
Dequeker
J
J
D000328:Adult; D044383:Black People / Q000235:genetics*; D015023:Democratic Republic of the Congo / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D015796:HLA-B27 Antigen / Q000235:genetics*; D006801:Humans; D008297:Male; D015995:Prevalence; D013167:Spondylitis, Ankylosing / Q000453:epidemiology / Q000235:genetics*
D015796:HLA-B27 Antigen