Urine levels of type 1 collagen cross-linked N-telopeptides and deoxypyridinoline correlate with disease activity in rheumatoid arthritis.
OBJECTIVE
The aim of this study was to find out whether spot urinary concentrations of type 1 collagen cross-linked N-telopeptides (NTx) and deoxypyridinoline (Pyrilinks-D) can differentiate between active and inactive disease in rheumatoid arthritis (RA) and to investigate the extent to which they correlate with indices of disease activity.


METHODS
Using enzyme-linked immunosorbent assays, the concentrations of NTx and Pyrilinks-D were estimated in spot urine samples from 25 females with active disease, 25 females with inactive disease, and in 25 controls.


RESULTS
In Patients with active disease, urinary concentrations of NTx and Pyrilinks-D were significantly higher (p < 0.01) than in those with inactive disease or in healthy controls. In active disease there were significant positive correlation between urinary NTx and ESR, the swollen joint count, the tender joint count, and the patient's global assessment.
Department of Medicine, Faculty of Medicine, Kuwait University, Al-Safat, Kuwait.
A M
AM
al-Awadhi
S O
SO
Olusi
N S
NS
al-Zaid
K
K
Prabha
K H
KH
al-Jarallah
A H
AH
Ahmed
I
I
al-Salem
H
H
Sedeqi
Y
Y
Atteyah
D000328:Adult; D000596:Amino Acids / Q000652:urine*; D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000652:urine*; D015415:Biomarkers / Q000652:urine*; D003094:Collagen / Q000652:urine*; D024042:Collagen Type I; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008875:Middle Aged; D010455:Peptides / Q000652:urine*; D012720:Severity of Illness Index
D000596:Amino Acids; D015415:Biomarkers; D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; C036020:deoxypyridinoline; D003094:Collagen