A comparative study on the efficacy of the new quinolone alatrofloxacin in the treatment of experimental legionellosis in guinea pigs.
The in vivo efficacy of trovafloxacin, intraperitoneally administered as alatrofloxacin (CP-116,517), was assessed and compared with that of erythromycin, alone or in combination with rifampicin, in a model of Legionella pneumophila pneumonia in guinea pigs. Trovafloxacin (5 mg/kg administered as alatrofloxacin once daily for 7 days) gave a survival rate of 100% in infected animals. Clearance of bacteria and of bacteria-induced lesions from lungs was achieved by day 6 post-inoculation. The lungs of trovafloxacin-treated animals remained free of bacteria at day 28 post-challenge. Trovafloxacin proved as effective as erythromycin administered intraperitoneally, but was superior to erythromycin alone. or in combination with rifampicin, when given orally.
García-de-Lomas
J
J
Department of Microbiology, Faculty of Medicine, Hospital Clinic, Valencia, Spain.
Millás
E
E
Lázaro
M A
MA
Bermejo
M
M
Gimeno
C
C
Navarro
D
D
Sánchez
S
S
D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination / Q000008:administration & dosage / Q000627:therapeutic use; D004917:Erythromycin / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D024841:Fluoroquinolones; D006168:Guinea Pigs; D007274:Injections, Intraperitoneal; D016952:Legionella pneumophila / Q000187:drug effects; D007877:Legionnaires' Disease / Q000188:drug therapy* / Q000382:microbiology; D008168:Lung / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D011355:Prodrugs / Q000627:therapeutic use*; D011897:Random Allocation; D012293:Rifampin / Q000008:administration & dosage / Q000627:therapeutic use
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D011355:Prodrugs; D004917:Erythromycin; C106856:alatrofloxacin; D012293:Rifampin