Urinary excretion of diethylstilbestrol in the ostrich.
Stilboestrol tablets (20 x 1 mg) were given to 4 ostriches. Urine was collected over a period of 8 days and stored frozen at-20 degrees C pending analysis. Analyses were performed on a gas chromatograph-mass selective detector for the presence of parent compound and/or metabolites. Diethylstilbestrol and its metabolite, dienestrol, were detected in urine; dienestrol only for 1 day but diethylstilbestrol for 8 days after administration. Residue analysis for the use of diethylstilbestrol as growth promoter can be performed on the urine of ostriches by scanning for parent compound only since it can be detected longer than the metabolite.
Department of Pharmacology, University of the Orange Free State, Bloemfontein, South Africa.
P J
PJ
van der Merwe
A
A
Pretorius
W
W
Burger
D000818:Animals; D002849:Chromatography, Gas / Q000662:veterinary; D004028:Dienestrol / Q000652:urine; D004054:Diethylstilbestrol / Q000652:urine*; D004350:Drug Residues / Q000032:analysis*; D020310:Struthioniformes / Q000652:urine*; D013997:Time Factors
D004054:Diethylstilbestrol; D004028:Dienestrol