Prophylactic antibiotics for spine surgery: description of a regimen and its rationale.
Cefazolin, an antibiotic commonly used for surgical prophylaxis, may not adequately penetrate the intervertebral disk or cerebrospinal fluid. The combination of gentamicin and cefuroxime has been found to penetrate both structures in adequate levels and was used in 40 consecutive elective spine cases without a postoperative infection or antibiotic-related complications.
Department of Orthopaedic Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21287-0882, USA.
L H
LH
Riley
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D002444:Cefuroxime / Q000008:administration & dosage / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002511:Cephalosporins / Q000008:administration & dosage / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002574:Cervical Vertebrae / Q000601:surgery*; D004359:Drug Therapy, Combination / Q000008:administration & dosage / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005839:Gentamicins / Q000008:administration & dosage / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D007275:Injections, Intravenous; D007403:Intervertebral Disc / Q000378:metabolism / Q000601:surgery*; D007430:Intraoperative Care; D008159:Lumbar Vertebrae / Q000601:surgery*; D008875:Middle Aged; D013530:Surgical Wound Infection / Q000517:prevention & control; D013997:Time Factors
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D005839:Gentamicins; D002444:Cefuroxime