Cutaneous angiomyolipoma: report of two cases with emphasis on HMB-45 utility.
BACKGROUND
Angiomyolipomas are tumors composed of adipose tissue, blood vessels and smooth muscle. Although renal angiomyolipomas are well known, cutaneous tumors have been described only recently. HMB-45 reactivity, reported for renal angiomyolipomas, has been suggested as a useful tool in differential diagnosis.


OBJECTIVE
Two cases of cutaneous angiomyolipoma are described and investigated for HMB-45 reactivity.


METHODS
Conventional histochemical and immunohistochemical methods were used.


RESULTS
Immunohistochemical analysis showed no reactivity for HMB-45 antibody.


CONCLUSIONS
We conclude that, unlike renal angiomyolipomas, HMB-45 reactivity is not helpful in differentiating cutaneous angiomyolipomas.
Department of Pathology, Istanbul University, Istanbul School of Medicine, Turkey.
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Büyükbabani
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Tetikkurt
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Oztürk
D000328:Adult; D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D006391:Hemangioma / Q000276:immunology / Q000473:pathology*; D006801:Humans; D008067:Lipoma / Q000276:immunology / Q000473:pathology*; D008297:Male; D012867:Skin / Q000276:immunology / Q000473:pathology; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology*
D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm