[Importance of the association ticarcillin-clavulanic acid-amikacin in the treatment of severe urinary infections after major urodigestive surgery. Report of 59 cases].
Ticarcillin-clavulanic acid (Claventin) and amikacin were administered in an open study to prevent and treat nosocomial urinary tract infections, to 59 patients after major urological surgery. Postoperative course was event-free in 44 cases. 10 patients presented asymptomatic urinary tract infections due to gram negative bacilli, that did not require any change in antimicrobial therapy. 5 patients experienced symptomatic nosocomial infections, whose one was associated with a methicillin-Resistant Staphylococcus aureus septicemia that was treated by vancomycin. The urinary tract infections were polymicrobial in only 3 cases. The tolerance was quite satisfactory, and the protocol was effective in about 92% of cases. The combination of ticarcillin-clavulanic acid-amikacin is valuable and can be used as first step therapy to preserve the ecology of the patients.
Département d'Anesthésie-Réanimation III, Hopital Pellegrin-Tondu, Bordeaux, France.
P
P
Tauzin-Fin
J M
JM
Ragnaud
P
P
Ballanger
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000583:Amikacin / Q000627:therapeutic use; D019818:Clavulanic Acid / Q000627:therapeutic use; D003428:Cross Infection / Q000188:drug therapy*; D013505:Digestive System Surgical Procedures / Q000009:adverse effects*; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D011182:Postoperative Care / Q000379:methods*; D013982:Ticarcillin / Q000627:therapeutic use; D014552:Urinary Tract Infections / Q000209:etiology / Q000517:prevention & control*; D013520:Urologic Surgical Procedures / Q000009:adverse effects*
D019818:Clavulanic Acid; D000583:Amikacin; D013982:Ticarcillin
Intérêt de l'association ticarcilline-acide clavulanique-amikacine dans le traitement des infections urinaires graves après chirurgie urodigestive majeure. A propos de 59 cas.