Polymorphisms of platelet membrane glycoprotein Ib associated with arterial thrombotic disease.
Platelet membrane glycoprotein Ibalpha (GPIbalpha) is a major receptor for von Willebrand factor and thrombin, which plays a key role in the initial development of thrombi. Two polymorphisms (HPA-2 and VNTR) that affect phenotype have been described in GPIbalpha. The relevance of these polymorphisms to thrombotic disease was investigated by genotypic identification in three case-control studies: 104 case patients with acute cerebrovascular disease (CVD), 101 case patients with acute coronary heart disease (CHD), 95 patients with deep venous thrombosis (DVT), and one control age-, sex-, and race-matched for each case patient. Results show that the C/B genotype of the VNTR and the HPA-2b polymorphisms of GPIbalpha are strongly associated with increased risk of coronary heart disease and cerebral vascular disease but not with deep vein thrombosis. These two polymorphisms of GPIbalpha may represent newly identified risk factors for arterial thrombotic disease, but not for venous thrombosis.
Unit of Hematology and Hemotherapy, and the Department of Neurology, School of Medicine. Hospital General Universitario, Murcia, Spain.
R
R
Gonzalez-Conejero
M L
ML
Lozano
J
J
Rivera
J
J
Corral
J A
JA
Iniesta
J M
JM
Moraleda
V
V
Vicente
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016824:Antigens, Human Platelet / Q000235:genetics*; D001157:Arterial Occlusive Diseases / Q000453:epidemiology / Q000235:genetics*; D001665:Binding Sites; D016022:Case-Control Studies; D002561:Cerebrovascular Disorders / Q000453:epidemiology / Q000235:genetics; D003327:Coronary Disease / Q000453:epidemiology / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000235:genetics*; D010980:Platelet Membrane Glycoproteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D011487:Protein Conformation; D011956:Receptors, Cell Surface / Q000235:genetics*; D018179:Receptors, Thrombin / Q000235:genetics*; D012307:Risk Factors; D013329:Structure-Activity Relationship; D013927:Thrombosis / Q000453:epidemiology / Q000235:genetics*; D020246:Venous Thrombosis / Q000453:epidemiology / Q000235:genetics
C115212:2a alloantigen, human; D016824:Antigens, Human Platelet; D019038:Platelet Glycoprotein GPIb-IX Complex; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface; D018179:Receptors, Thrombin; C028254:von Willebrand factor receptor