Dupuytren's disease and frozen shoulder induced by treatment with a matrix metalloproteinase inhibitor.
In a series of 12 patients with inoperable gastric carcinoma who had treatment with a synthetic matrix metalloproteinase inhibitor (Marimastat) for more than one month, six developed a frozen shoulder or a condition resembling Dupuytren's disease. This suggests that the matrix metalloproteinases, a family of naturally occurring proteinases, may be involved in the pathogenesis of these two conditions. Our observation opens avenues for further research which could lead to local or systemic therapeutic interventions for frozen shoulder and Dupuytren's disease.
Queen's Medical Centre, Nottingham, England, UK.
J W
JW
Hutchinson
G M
GM
Tierney
S L
SL
Parsons
T R
TR
Davis
D000230:Adenocarcinoma / Q000188:drug therapy; D002062:Bursitis / Q000139:chemically induced*; D004387:Dupuytren Contracture / Q000139:chemically induced*; D004791:Enzyme Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D006877:Hydroxamic Acids / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors*; D013274:Stomach Neoplasms / Q000188:drug therapy
D004791:Enzyme Inhibitors; D006877:Hydroxamic Acids; C100342:marimastat; D008666:Metalloendopeptidases