A family study of anterior mitral leaflet thickness and mitral valve prolapse.
To determine whether mitral valve prolapse (MVP) with or without mitral leaflet thickening (> or =5 mm) represents distinct heritable conditions, 13 patients with MVP with leaflet thickening and their relatives were compared with 67 patients with MVP with normal leaflets and their relatives. The 2 groups of relatives had similar mitral leaflet thicknesses and similar long-term outcome, arguing against the existence of a distinctive subtype of MVP characterized by increased mitral leaflet thickness.
Zuppiroli
A
A
Department of Medicine, The New York Hospital-Cornell Medical Center, New York 10021, USA.
Roman
M J
MJ
O'Grady
M
M
Devereux
R B
RB
D000328:Adult; D001794:Blood Pressure; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008945:Mitral Valve Prolapse / Q000000981:diagnostic imaging / Q000235:genetics* / Q000503:physiopathology; D010375:Pedigree; D010701:Phonocardiography; D011795:Surveys and Questionnaires