[Recent issue in the treatment of small-cell lung cancer].
Chemotherapy is currently a primary treatment modality for small-cell lung cancer (SCLC). However, in the limited stage, a combination of chemotherapy and thoracic irradiation (TI) was found to be superior to chemotherapy alone by meta-analysis. Recently, concurrent administration of cisplatin and etoposide with TI may be an optimal treatment. The usefulness of prophylactic cranial irradiation in complete responders was also confirmed by meta-analysis. Dose-intensive weekly chemotherapy failed to improve the treatment outcome in the extensive stage. Randomized trials to verify the effectiveness of high-dose chemotherapy with peripheral blood stem cell transplantation are in progress.
Dept. of Internal Medicine II. Okayama University Medical School, Japan.
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D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018288:Carcinoma, Small Cell / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D004334:Drug Administration Schedule; D005047:Etoposide / Q000008:administration & dosage; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*
D005047:Etoposide; D002945:Cisplatin