Cutaneous aspergillosis: a report of six cases.
Skin invasion by Aspergillus is infrequent. We here describe six immunocompromised patients with skin manifestations caused by Aspergillus. A heart transplant recipient developed a primary cutaneous aspergillosis; two patients (one with chronic granulomatous disease and another treated with a high dose of corticosteroids) presented with nodular lesions secondary to haematogenous dissemination; and three patients with acute myelogenous leukaemia had skin dissemination by contiguity from orbit and sinus invasion. A. flavus was isolated in the three cases of leukaemia; the infection was due to A. fumigatus in the transplant recipient; A. fumigatus and A. versicolor were isolated in the patients with the secondary aspergillosis. In most cases, amphotericin B was useful, with clinical and mycological remission in four patients. A patient with leukaemia died without undergoing treatment, and a child carrier of chronic granulomatous disease died after only 12 days of treatment.
Galimberti
R
R
Department of Dermatology, Hospital Italiano, Gascón 450, CP 1181, Buenos Aires, Argentina.
Kowalczuk
A
A
Hidalgo Parra
I
I
Gonzalez Ramos
M
M
Flores
V
V
D000368:Aged; D001228:Aspergillosis / Q000276:immunology / Q000473:pathology*; D002648:Child; D003881:Dermatomycoses / Q000276:immunology / Q000473:pathology*; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000276:immunology / Q000473:pathology*