Age-related increased susceptibility of high-density lipoproteins (HDL) to in vitro oxidation induced by gamma-radiolysis of water.
In the present study, we investigated the age-related susceptibility of high-density lipoproteins (HDL) to oxidation. HDL were obtained from healthy, normolipidemic young, middle-aged and elderly subjects. Oxidation of HDL was induced in vitro by oxygen free radicals generated by water gamma-radiolysis, and followed by the decrease of endogenous vitamin E and the formation of conjugated dienes and thiobarbituric acid-reactive substances, as well as the alterations of apolipoproteins A-I/A-II. The resistance of HDL to oxidation, evaluated by the length of the lag phase, decreased with aging. This increased oxidizability of HDL with aging could have a dramatic impact on the development of atherosclerosis in the elderly population.
Laboratoire de Biogérontologie, Institut Universitaire de Gériatrie de Sherbrooke, Qué, Canada.
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A
Khalil
J P
JP
Jay-Gerin
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T
Fülöp
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D006801:Humans; D008075:Lipoproteins, HDL / Q000378:metabolism* / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D011675:Pulse Radiolysis; D014867:Water
D008075:Lipoproteins, HDL; D014867:Water