[The effect of rudotel on the synaptic activity of dopaminergic neurons].
The work discusses the neurochemical correlates of rat brain dopamin-synaptic activity after injection of 0.5 mg/kg rudotel (medazepam) as compared with intact animals. The parameters of functioning of D2-receptors in [3H]-dopamine binding, the content of catecholamines and their metabolites (high-performance liquid chromatography with electrochemical detection) were studied in the dopaminergic system in different brain areas (the striatum, frontal cortex, amygdala, hippocampus, hypothalamus, and accumbence).
Podgornaia
E K
EK
Institute of Inorganic Chemistry, Siberian Branch, Academy of Sciences, Novosibirsk, Russia.
Galkina
O V
OV
Il'iuchenok
R Iu
RIu
Poliakov
O V
OV
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D002395:Catecholamines / Q000378:metabolism; D008297:Male; D008472:Medazepam / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D011954:Receptors, Dopamine / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*
D014151:Anti-Anxiety Agents; D002395:Catecholamines; D011954:Receptors, Dopamine; D008472:Medazepam
Vliianie rudotelia na sinapticheskuiu aktivnost' dofaminergicheskikh neĭronov.