Simultaneous infection with Blastomyces dermatitidis and Cryptococcus neoformans.
In this report, we present two cases of simultaneous infection with Blastomyces dermatitidis and Cryptococcus neoformans. In both cases, fungi were isolated from the lungs. The clinical manifestations were not suggestive of infection with two fungi. One patient was receiving immunosuppressive therapy and another was otherwise immunocompetent. A review of the literature failed to uncover any reports of co-infection with these two fungal pathogens. We discuss possible mechanisms for the isolation of both pathogens.
Mounts
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Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0560, USA.
Deepe
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D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001758:Blastomyces / Q000302:isolation & purification*; D001759:Blastomycosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D003453:Cryptococcosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D003455:Cryptococcus neoformans / Q000302:isolation & purification*; D006801:Humans; D016867:Immunocompromised Host; D017964:Itraconazole / Q000627:therapeutic use; D008172:Lung Diseases, Fungal / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged
D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B