Progress in the design of DNA sequence-specific lexitropsins.
Sequence-specific polyamides that bind in the minor groove of DNA are attractive candidates for antibiotics, cancer chemotherapeutics, and transcriptional antagonists. This paper reviews the progress of structure-based design of minor-groove-binding polyamides, from the first structure of netropsin with DNA, to the effective linked polyamides currently under study. A theory of polyamide specificity is also reviewed, introducing methods to determine the optimal strategies for targeting a given DNA sequence within a genome of competing sequences.
Department of Biomathematics, University of California at Los Angeles 90095, USA.
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Walker
M L
ML
Kopka
D S
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Goodsell
D000970:Antineoplastic Agents / Q000737:chemistry; D000998:Antiviral Agents / Q000737:chemistry; D001483:Base Sequence; D001665:Binding Sites; D004247:DNA / Q000737:chemistry*; D015195:Drug Design; D008958:Models, Molecular; D009429:Netropsin / Q000031:analogs & derivatives* / Q000737:chemistry; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides; D011487:Protein Conformation
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D009838:Oligodeoxyribonucleotides; C053654:lexitropsin; D009429:Netropsin; D004247:DNA