Changes in refractoriness of rabbit corpora lutea to a prostaglandin F2 alpha analogue, alfaprostol, during pseudopregnancy.
The responsiveness of rabbit corpus luteum to 200 micrograms of the prostaglandin F2 alpha (PGF2 alpha) analogue, alfaprostol, between Days 3 and 9 of pseudopregnancy was assessed by evaluating the decline in plasma progesterone after treatment with PGF2 alpha in 81 New Zealand White (NZW) rabbits. On Days 3-5, functional luteolysis was not observed. On Days 6, 7, and 8 of pseudopregnancy, the number of rabbits responsive to PGF2 alpha, rose from 38% to 71% and 83%, respectively. In the other cases, the effect of the PGF2 alpha analogue was transient as CL recovered in the following 2 or 3 days. By contrast, on Day 9 luteolysis was effective and persistent in all the animals. In rabbits treated on Day 9, progesterone decreased gradually from 10.6 +/- 0.7 within the first 6 h, but fell to 3.6 +/- 1.5 ng/mL (p < 0.01) 12 h after PGF2 alpha and to 0.2 +/- 0.1 ng/mL (p < 0.01) 24 h later.
Boiti
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C
Istituto di Fisiologia veterinaria, Università di Perugia, Italia.
Canali
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C
Zerani
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M
Gobbetti
A
A
D000818:Animals; D003338:Corpus Luteum / Q000187:drug effects* / Q000502:physiology*; D015237:Dinoprost / Q000031:analogs & derivatives; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology; D006064:Gonadotropins, Equine / Q000494:pharmacology; D011374:Progesterone / Q000097:blood*; D011460:Prostaglandins F / Q000494:pharmacology*; D011555:Pseudopregnancy / Q000139:chemically induced / Q000188:drug therapy*; D011817:Rabbits
D006064:Gonadotropins, Equine; D011460:Prostaglandins F; D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone; C038354:alfaprostol; D015237:Dinoprost