Multiple stress fractures in a scleroderma patient on methotrexate therapy.
A patient on methotrexate therapy for scleroderma developed four stress fractures within a period of 13 months. She was not on steroid therapy and had no risk factors for osteoporosis. A review of the literature found 13 cases of stress fractures under methotrexate therapy. Whether methotrexate can induce bone changes remains controversial.
Rheumatology Department, Saint Antoine Teaching Hospital, Paris, France.
M
M
Singwe
L
L
Le Gars
A
A
Karneff
A
A
Prier
G
G
Kaplan
D005260:Female; D005493:Folic Acid Antagonists / Q000009:adverse effects*; D005500:Follow-Up Studies; D005598:Fractures, Spontaneous / Q000139:chemically induced* / Q000175:diagnosis; D015775:Fractures, Stress / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D008727:Methotrexate / Q000009:adverse effects*; D008875:Middle Aged; D012595:Scleroderma, Systemic / Q000150:complications* / Q000188:drug therapy
D005493:Folic Acid Antagonists; D008727:Methotrexate