[The bioavailability of tableted drug forms of the new Russian nootropic preparation nooglutil in rabbits].
Comparative study of the main pharmacokinetic characteristics and evaluation of the bioavailability of two experimental tablet forms of the new nootropic nooglutil in relation to the substance of the drug were conducted on rabbits. The nooglutil content in plasma samples was determined by high performance liquid chromatography. Significant advantage of one tablet of the drug containing tween-80 was demonstrated. Bioavailability of this drug form of nooglutil in relation to the substance of the drug was 104.3%.
Laboratory of Pharmacokinetics, Russian Academy of Medical Sciences, Moscow, Russia.
E A
EA
Chesnokova
A K
AK
Sariev
V P
VP
Zherdev
V S
VS
Kartashov
L D
LD
Smirnov
D000818:Animals; D001682:Biological Availability; D002138:Calibration; D002214:Capsules; D002851:Chromatography, High Pressure Liquid; D002853:Chromatography, Liquid; D005971:Glutamates / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D009539:Nicotinic Acids / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D018697:Nootropic Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D011817:Rabbits; D013607:Tablets; D013997:Time Factors
D002214:Capsules; D005971:Glutamates; D009539:Nicotinic Acids; D018697:Nootropic Agents; D013607:Tablets; C066295:nooglutil
Biodostupnost' tabletirovannykh lekarstvennykh form novogo otechestvennogo nootropnogo preparata noogliutila u krolikov.