Induction of ovarian tumors by heavy ion irradiation in B6C3F1 mice.
Six-week-old B6C3F1 mice were exposed to 0.439 Gy heavy ion irradiation as a 290 MeV/u carbon-ion beam (LET 10 keV/micron) at 2 cm from the upper proximal point of a spread Bragg beam and autopsied 13.5 months after the irradiation. In males total tumor incidences, mainly liver tumors, were 37.0% in irradiated group and 25.0% in control (P>0.05). In females the total tumor incidences were 32.3%, mainly ovarian tumors, in the irradiated group and 0% in the controls. These results indicate that heavy ion irradiation induces ovarian tumors in females but does not target any organ in males.
Department of Environment and Mutation, Research Institute for Radiation Biology and Medicine, Hiroshima University, Minami-ku, Hiroshima 734-8553, Japan.
H
H
Watanabe
T
T
Ogiu
M
M
Nishizaki
N
N
Fujimoto
S
S
Kido
Y
Y
Ishimura
K
K
Shiraki
K
K
Kuramoto
S
S
Hirata
S
S
Shoji
O
O
Katoh
D000311:Adrenal Glands / Q000528:radiation effects; D000818:Animals; D003433:Crosses, Genetic; D005260:Female; D020450:Heavy Ions; D007668:Kidney / Q000528:radiation effects; D008113:Liver Neoplasms / Q000209:etiology* / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D009929:Organ Size / Q000528:radiation effects; D010051:Ovarian Neoplasms / Q000209:etiology* / Q000473:pathology; D010053:Ovary / Q000528:radiation effects; D012727:Sex Characteristics; D013154:Spleen / Q000528:radiation effects; D013737:Testis / Q000528:radiation effects