The mouse Fkh1/Mf1 gene: cDNA sequence, chromosomal localization and expression in adult tissues.
The 'winged helix' or 'forkhead' transcription factor gene family is defined by a common 100-amino-acid DNA-binding motif. Here, we describe the chromosomal position, start site of transcription, sequence and adult expression pattern of the mouse Fkh1/Mf1 (Forkhead homologue 1/mesoderm/mesenchyme forkhead 1) gene. This gene contains one exon and encodes a protein of 553 amino acids that is highly related to the mouse MFH1 protein. The Fkh1/Mf1 mRNA is expressed widely in adult tissues. Linkage analysis showed that the Fkh1/Mf1 gene is localized to chromosome 13 at 17.02cM from the centromer, in close proximity to Bmp6 and Hfh1, another distinct member of the winged helix gene family.
Hiemisch
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Division Molecular Biology of the Cell I, German Cancer Research Center, Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany.
Schütz
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Kaestner
K H
KH
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D002874:Chromosome Mapping; D018076:DNA, Complementary / Q000302:isolation & purification*; D004622:Embryo, Mammalian / Q000737:chemistry; D051858:Forkhead Transcription Factors; D015870:Gene Expression / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D012313:RNA / Q000032:analysis; D017422:Sequence Analysis, DNA; D014157:Transcription Factors / Q000096:biosynthesis / Q000235:genetics* / Q000302:isolation & purification
D018076:DNA, Complementary; D051858:Forkhead Transcription Factors; C112890:Foxc1 protein, mouse; D014157:Transcription Factors; D012313:RNA