[Hypoplasia of the penis: etiologic diagnosis and results of treatment with delayed-action testosterone].
BACKGROUND
Results of long-term testosterone treatment of congenital hypoplasia of the penis are sparse; the aim of this work was to evaluate these results according to age at onset of treatment, the presence or absence of hypospadias, and its eventual adverse effect upon growth and bone maturation.


METHODS
Sixty-six children with congenital hypoplasia of the penis, isolated (n = 31) or associated with a hypospadias (n = 35), were evaluated between 1 day and 16 years of age. The prevalence (40% of the cases) of the different malformations and/or syndromes associated with congenital hypoplasia and its severity were not different whether the penis was isolated or associated with hypospadias (male-pseudohermaphroditism). The effect of the testosterone heptylate (IM) was evaluated in 40 children treated before 10 years of age.


RESULTS
The penis' increase in length was more important in the children with isolated micropenis (+2.1 +/- 0.8 SDS) than those with hypospadias (+1.3 +/- 1.2 SDS) but, in all cases, its increase was better when the treatment was started during the neonatal period, which corresponded to those with the most severe forms of micropenis. A mean regression of the penile volume of -0.7 +/- 0.8 SDS was noticed after the end of each stimulation. No long-term secondary effects related to treatment were seen on later growth and bone-maturation.


CONCLUSIONS
Penile length at the last follow-up was not associated with total dose of testosterone but with its length at the first evaluation time (r = 0.52; P = 0.002).
Service d'endocrinologie pédiatrique et diabète, hôpital Robert-Debré, Paris, France.
A
A
Velásquez-Urzola
J
J
Léger
Y
Y
Aigrain
P
P
Czernichow
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003692:Delayed-Action Preparations; D012734:Disorders of Sex Development / Q000188:drug therapy; D005500:Follow-Up Studies; D006801:Humans; D007021:Hypospadias / Q000188:drug therapy*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010413:Penis / Q000002:abnormalities* / Q000187:drug effects; D013739:Testosterone / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D016896:Treatment Outcome
D003692:Delayed-Action Preparations; D013739:Testosterone; C004648:testosterone enanthate
Hypoplasie de la verge: diagnostic étiologique et résultat du traitement par testostérone retard.