Spirofungin, a new antifungal antibiotic from Streptomyces violaceusniger Tü 4113.
A new secondary metabolite was detected in the culture filtrate and extracts of Streptomyces violaceusniger Tü 4113 by HPLC-diode-array and HPLC-electrospray-mass-spectrometry screening. The compound named spirofungin has a polyketide-spiroketal structure and shows various antifungal activities, particularly against yeasts.
Höltzel
A
A
Institut für Organische Chemie, Universität Tübingen, Germany.
Kempter
C
C
Metzger
J W
JW
Jung
G
G
Groth
I
I
Fritz
T
T
Fiedler
H P
HP
D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013141:Spiro Compounds / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces; D015003:Yeasts / Q000187:drug effects
D000935:Antifungal Agents; D013141:Spiro Compounds; C114877:spirofungin A