Encouraging response of an advanced steroid-cell tumor to GnRH agonist therapy.
BACKGROUND
Chemotherapy for steroid tumors of unspecified type has met with limited success and the overall prognosis has been poor.


METHODS
A patient with a virilizing steroid tumor, otherwise unspecified, with demonstrated progressive disease after surgical debulking. Treatment with multiagent chemotherapy failed, but the patient subsequently had a robust response to GnRH agonist therapy.


CONCLUSIONS
GnRH analogue treatment should be considered prior to cytotoxic chemotherapy in cases of steroid tumor, not otherwise specified.
Brewer
C A
CA
Department of Obstetrics and Gynecology, Southern Illinois University School of Medicine, and St. John's Hospital, Springfield 62794-1315, USA.
Shevlin
D
D
D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D016729:Leuprolide / Q000627:therapeutic use*; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology; D012074:Remission Induction
D018931:Antineoplastic Agents, Hormonal; D016729:Leuprolide