Synthesis and aldose reductase inhibitory activity of benzoyl-amino acid derivatives.
A series of N-(4-methoxy, 4-fluoro, 4-trifluoromethyl and 4-nitrobenzoyl)-L-amino acids was synthesized and their inhibitory activity towards bovine lens aldose reductase (ALR2) was tested.
Benvenuti
S
S
Dipartimento di Scienze Farmaceutiche, Università di Modena, Italy.
Severi
F
F
Costantino
L
L
Vampa
G
G
Melegari
M
M
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D002417:Cattle; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007908:Lens, Crystalline / Q000201:enzymology
D000596:Amino Acids; D004791:Enzyme Inhibitors; D000449:Aldehyde Reductase