ECG conduction delays associated with massive bupropion overdose.
BACKGROUND
Bupropion, a relatively new antidepressant, is highly regarded for its safety profile in therapeutic doses and in the overdose. Seizure is the primary adverse reaction associated with bupropion overdoses. Clinically significant cardiovascular complications are rare.


METHODS
We report the case of an adult male who ingested 9 g bupropion and developed neurologic toxicity as well as intraventricular conduction disturbances on electrocardiogram. Cardiac monitoring of these patients should be considered.
Department of Emergency Medicine, Maine Medical Center, Portland 04102, USA. parisp@mail.mmc.org
P A
PA
Paris
J R
JR
Saucier
D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000506:poisoning*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy; D016642:Bupropion / Q000506:poisoning*; D003693:Delirium / Q000139:chemically induced / Q000188:drug therapy; D062787:Drug Overdose; D004562:Electrocardiography / Q000187:drug effects; D006329:Heart Conduction System / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D008297:Male; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy; D016896:Treatment Outcome
D018687:Antidepressive Agents, Second-Generation; D016642:Bupropion