Intramedullary abscess of the spinal cord in the antibiotic era: clinical features, microbial etiologies, trends in pathogenesis, and outcomes.
We review the clinical features, microbial etiologies, mechanisms of infection, and outcomes of 25 cases of intramedullary abscess of the spinal cord (IASC) reported between 1977 and 1997, the modern era. All patients presented with motor and/or sensory neurological deficits. Back pain and/or radicular pain was common (60%); fever was present in a minority (40%) of patients. Preexisting abnormalities of the spinal cord and/or vertebral column were present in 44% of cases. Contiguous spread of infection through a congenital dermal sinus was the mechanism of infection in 24% of cases. The infection was fatal in 8% of cases; persistent neurological deficits were documented in 70% of patients who survived. To assess the impact of antimicrobial therapy on the pathogenesis and outcomes of IASC, cases reported in the modern era are compared with 42 cases of IASC reported between 1830 and 1944, the preantibiotic era.
Division of General Internal Medicine, Toronto Hospital, University of Toronto, Ontario, Canada.
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Chan
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D000038:Abscess / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology / Q000503:physiopathology*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D006801:Humans; D017063:Outcome Assessment, Health Care; D013118:Spinal Cord Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology / Q000503:physiopathology*
D000900:Anti-Bacterial Agents