[The decrease of gastric mucosal blood flow in obstructive jaundice under stress].
OBJECTIVE
To investigate the cause of decrease of gastric mucosal blood flow (GMBF) in obstructive jaundice under stress.


METHODS
With common bile duct ligation (CBDL) in Wistar rats under cold restraint stress, GMBF and the content of Endothelin-1, Angiotensin-II, H2, alpha 1 receptor in gastric mucosa were measured. Before stress anti-ET-1 serum, Enalapril, Cimentidine and Phetolamins were administrated, and the change of GMBF was studied.


RESULTS
GMBF was significantly decreased in CBDL in stress than those in control subjects. The content of ET1 and Ang-II was significantly increaced, the density of H2 and alpha 1 receptor was significantly decreased. Before stress antagonist was administrated, and GMBF was significantly increased.


CONCLUSIONS
GMBF was decreased by increased ET, Ang-II and decreased H2, alpha 1 receptor in CBDL, under stress. Antagonist improved gastric mucosal blood flow. They had protection from gastric mucosa.
Department of Surgery, People's Hospital, Beijing Medical University.
N
N
Yang
W
W
Xu
J
J
Duan
D000804:Angiotensin II / Q000378:metabolism; D000818:Animals; D002779:Cholestasis / Q000503:physiopathology*; D003080:Cold Temperature; D019332:Endothelin-1 / Q000378:metabolism*; D005753:Gastric Mucosa / Q000098:blood supply*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011970:Receptors, Histamine H2 / Q000378:metabolism; D012039:Regional Blood Flow; D013276:Stomach Ulcer / Q000517:prevention & control; D013312:Stress, Physiological
D019332:Endothelin-1; D011970:Receptors, Histamine H2; D000804:Angiotensin II