Opioid receptor mediated anticonvulsant effect of pentazocine.
Intraperitoneal (i.p.) administration of (+/-) pentazocine (10, 30 & 50 mg/kg), a Sigma opioid agonist, resulted in a dose dependent anticonvulsant action against maximal electroshock seizures in mice. This anticonvulsant effect of pentazocine was not antagonized by both the doses of naloxone (1 and 10 mg/kg) suggesting thereby that its anticonvulsant action is probably mediated by Sigma opiate binding sites. Its anticonvulsant effect was potentiated by both the anticonvulsant drugs viz. diazepam and diphenylhydantoin. Morphine, mu opioid agonist, on the other hand, failed to protect the animals against maximal electroshock seizures when it was given in doses of 10-40 mg/kg body wt.
Department of Pharmacology, University College of Medical Sciences, Delhi.
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N
Khanna
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Khosla
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J
Kohli
D000701:Analgesics, Opioid / Q000627:therapeutic use*; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D003975:Diazepam / Q000627:therapeutic use; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009270:Naloxone / Q000627:therapeutic use; D009292:Narcotic Antagonists / Q000627:therapeutic use; D010423:Pentazocine / Q000627:therapeutic use*; D012640:Seizures / Q000188:drug therapy*; D016896:Treatment Outcome
D000701:Analgesics, Opioid; D000927:Anticonvulsants; D009292:Narcotic Antagonists; D009270:Naloxone; D003975:Diazepam; D010423:Pentazocine