Polyethylene glycol (PEG) modified bovine pericardium as a biomaterial: a comparative study on immunogenicity.
Bioprosthetic heart valves made from glutaraldehyde (GA)-fixed porcine aortic valves or bovine pericardium (BP) are having some advantages over mechanical valves. However, their durability is low due to the calcification and immunological rejection. Study on immunogenicity is an important part in understanding the biocompatibility of materials. Polyethylene glycol (PEG) on pericardium can control biodegradation and calcification. Also, PEG exhibits low immunogenicity. We have studied the complement activation potential and the contribution of complement factors (biologic factors) on the calcification of PEG grafted pericardium samples and compared with standard (control) glutaraldehyde-treated pericardium samples. PEG-grafted BP activated using GA and carbodiimide (EDC) could be selected for further studies since complement activation and calcification observed on these samples has been relatively low.
Aravind
S
S
Division of Biosurface Technology, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Trivandrum, India.
Paul
W
W
Vasudev
S C
SC
Sharma
C P
CP
D000818:Animals; D001705:Bioprosthesis; D001798:Blood Proteins / Q000378:metabolism; D002114:Calcinosis / Q000209:etiology / Q000276:immunology / Q000517:prevention & control; D002118:Calcium / Q000032:analysis / Q000378:metabolism; D002417:Cattle; D020099:Coated Materials, Biocompatible; D003167:Complement Activation / Q000276:immunology*; D005976:Glutaral / Q000737:chemistry; D006801:Humans; D020007:Implants, Experimental; D010496:Pericardium / Q000737:chemistry* / Q000276:immunology*; D011092:Polyethylene Glycols / Q000737:chemistry*; D019736:Prostheses and Implants; D011485:Protein Binding; D051381:Rats; D017208:Rats, Wistar
D001798:Blood Proteins; D020099:Coated Materials, Biocompatible; D011092:Polyethylene Glycols; D002118:Calcium; D005976:Glutaral