The integration of medicinal chemistry, drug metabolism, and pharmaceutical research and development in drug discovery and development. The story of Crixivan, an HIV protease inhibitor.
Lin
J H
JH
Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, USA.
Ostovic
D
D
Vacca
J P
JP
D000818:Animals; D015195:Drug Design; D017320:HIV Protease Inhibitors / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D019469:Indinavir / Q000737:chemistry / Q000378:metabolism*; D007408:Intestinal Absorption; D012995:Solubility
D017320:HIV Protease Inhibitors; D019469:Indinavir