Developmental expression of the cell adhesion molecule-like protein tyrosine phosphatases LAR, RPTPdelta and RPTPsigma in the mouse.
Using RNA in situ hybridization we compared the expression patterns of the cell adhesion molecule-like receptor-type protein tyrosine phosphatases LAR, RPTP sigma and RPTP sigma during mouse development. We found that LAR is expressed in basal lamina-associated epithelial tissues of (neuro)ectodermal, neural crest/ectomesenchyme and endodermal origin. RPTP sigma is found in (neuro)ectodermal, neural crest-derived systems and in mesoderm-derived tissues. The expression pattern of RPTP sigma largely parallels that of RPTP sigma, in concordance with their proposed evolutionary history
Department of Cell Biology and Histology, Institute of Cellular Signalling, University of Nijmegen, Adelbertusplein 1, 6525 EK, Nijmegen, The Netherlands.
R Q
RQ
Schaapveld
J T
JT
Schepens
D
D
Bächner
J
J
Attema
B
B
Wieringa
P H
PH
Jap
W J
WJ
Hendriks
D000818:Animals; D015815:Cell Adhesion Molecules / Q000235:genetics*; D004622:Embryo, Mammalian / Q000378:metabolism; D005314:Embryonic and Fetal Development / Q000235:genetics*; D005260:Female; D005333:Fetus / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D017403:In Situ Hybridization; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D009419:Nerve Tissue Proteins / Q000235:genetics; D017027:Protein Tyrosine Phosphatases / Q000235:genetics*; D012313:RNA / Q000235:genetics / Q000378:metabolism; D054623:Receptor-Like Protein Tyrosine Phosphatases, Class 2; D054630:Receptor-Like Protein Tyrosine Phosphatases, Class 4; D054633:Receptor-Like Protein Tyrosine Phosphatases, Class 5; D011956:Receptors, Cell Surface; D014018:Tissue Distribution
D015815:Cell Adhesion Molecules; D009419:Nerve Tissue Proteins; D011956:Receptors, Cell Surface; D012313:RNA; D017027:Protein Tyrosine Phosphatases; C516843:Ptpra protein, mouse; C516851:Ptprg protein, mouse; C516885:Ptprs protein, mouse; D054623:Receptor-Like Protein Tyrosine Phosphatases, Class 2; D054630:Receptor-Like Protein Tyrosine Phosphatases, Class 4; D054633:Receptor-Like Protein Tyrosine Phosphatases, Class 5