Prevention of DOI-mediated wet dog shakes by inhibitors of nitric oxide synthase.
The purpose of this study was to determine if (+/-)-1-(2, 5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-induced wet dog shakes (WDS) required the involvement of nitric oxide synthases (NOS). Systemic administration of the general NOS inhibitor NG-nitro-L-arginine methyl ester (L-NAME), but not its d-isomer, and the neuronal NOS (nNOS) inhibitor 7-nitroindazole completely blocked DOI-mediated WDS in a dose dependent manner. The data provides evidence that serotonin 5HT2 receptors are coupled to nNOS activation in the rat brain.
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Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, 3200 S. University Dr., Ft. Lauderdale, FL 33328, USA.
Miller
K J
KJ
D000662:Amphetamines / Q000037:antagonists & inhibitors* / Q000633:toxicity; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D007191:Indazoles / Q000494:pharmacology; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000378:metabolism; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D052248:Nitric Oxide Synthase Type I; D051381:Rats; D017207:Rats, Sprague-Dawley; D017366:Serotonin Receptor Agonists / Q000633:toxicity*
D000662:Amphetamines; D004791:Enzyme Inhibitors; D007191:Indazoles; D007527:Isoenzymes; D017366:Serotonin Receptor Agonists; D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I; C496322:Nos1 protein, rat; C015952:4-iodo-2,5-dimethoxyphenylisopropylamine; C080122:7-nitroindazole; D019331:NG-Nitroarginine Methyl Ester