SLASH: a program for analysing the functional groups in molecules.
The program SLASH, which is designed to enable large numbers of compounds to be analysed in terms of the functional groups they contain, is described. The usefulness of the groups for analysing the activities of compounds tested in high-throughput biological screens is investigated. The functional group fragments are also studied as a means of determining similarity within groups of compounds.
Cosgrove
D A
DA
Zeneca Pharmaceuticals, Macclesfield, Cheshire, UK.
Willett
P
P
D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D008956:Models, Chemical; D015394:Molecular Structure; D012984:Software; D013329:Structure-Activity Relationship