[Effects of induction of anti-embryonation and anti-fecundity immunity on liver granuloma formation in mice infected with Schistosoma japonicum].
OBJECTIVE
To investigate the effect of anti-fecundity and anti-embryonation immunity on liver granuloma formation in mice immunized with soluble immature egg antigen (SIEA) of schistosoma japonicum.


METHODS
BALB/c mice were immunized with the crude SIEA or 26,000-28,000 molecular antigen derived from SIEA and compared the size in schistosoma japonicum egg granulomas in the liver after challenge infection both the immunized mice and unimmunized controls.


RESULTS
The number and size of egg granuloma were significantly decreased in mice immunized with SIEA and SIEA 26-28,000, by 29.26% and 49.64%, respectively. The inhibitive effects on granuloma formation and spleen weights in the group immunized with SIEA 26-28,000 were stronger than those in the group immunized with the crude SIEA. However, mean granuloma size and spleen weights in the group immunized with SEA or SIEA-1 fraction were not different from unimmunized control.


CONCLUSIONS
SIEA and SIEA 26-28,000 antigenic molecule play an important role in inhibition on liver granuloma formation through their anti-embryonation and anti-fecundity immunity effects.
Human University, Postdoctoral Research Station, Changsha.
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Wang
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Zhou
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Zhang
D000818:Animals; D000947:Antigens, Helminth; D015745:Granuloma, Foreign-Body / Q000276:immunology* / Q000517:prevention & control; D008107:Liver Diseases / Q000469:parasitology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010063:Ovum; D012549:Schistosoma japonicum / Q000276:immunology*; D012554:Schistosomiasis japonica / Q000276:immunology*
D000947:Antigens, Helminth