Cloning and characterization of a human and murine T-cell orphan G-protein-coupled receptor similar to the growth hormone secretagogue and neurotensin receptors.
Growth hormone secretagogues (GHS) are a group of synthetic peptide and nonpeptide molecules that potently stimulate the release of GH from the anterior pituitary gland through the activation of a novel G-protein-coupled receptor (GPC-R), the GHS-R. In our search for GHS-R family members, we recently described the cloning of two related GPC-Rs, GPR38 and 39. In the present report, we detail the isolation of a new GPC-R (FM-3) from human and mouse with moderate sequence identity to both the GHS-R and neurotensin-R. FM-3 is expressed in a diverse set of tissues.
Tan
C P
CP
Department of Biochemistry and Physiology, Merck Research Laboratories, Building RY-80Y-265, Rahway, New Jersey, 07065, USA.
McKee
K K
KK
Liu
Q
Q
Palyha
O C
OC
Feighner
S D
SD
Hreniuk
D L
DL
Smith
R G
RG
Howard
A D
AD
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D003001:Cloning, Molecular; D004247:DNA / Q000737:chemistry / Q000235:genetics; D018076:DNA, Complementary / Q000737:chemistry / Q000235:genetics; D019204:GTP-Binding Proteins / Q000378:metabolism*; D015870:Gene Expression; D006801:Humans; D008565:Membrane Proteins; D051379:Mice; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000235:genetics* / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled; D054440:Receptors, Ghrelin; D018028:Receptors, Neurotensin / Q000235:genetics*; D017981:Receptors, Neurotransmitter; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D013601:T-Lymphocytes / Q000737:chemistry / Q000378:metabolism*; D014018:Tissue Distribution; D014162:Transfection
D018076:DNA, Complementary; D008565:Membrane Proteins; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D054440:Receptors, Ghrelin; D018028:Receptors, Neurotensin; D017981:Receptors, Neurotransmitter; C082444:neuromedin U receptor; D004247:DNA; D019204:GTP-Binding Proteins