[Ph1-positive acute myeloid leukemia de novo or blast crisis of chronic myeloid leukemia? Molecular analysis and clinical course of a case].
A case of AML presented with basophilia in peripheral blood and Ph1 chromosome in karyotype analysis is reported. After one year of treatment with intensive chemotherapy and clinical and hematological remission, molecular analysis (RT-PCR) detected minimal residual disease (b2-a2 rearrangement). Thus, the patient relapsed as AML and, after second remission, he developed a hematological picture of chronic CML. Ten months later, he relapsed again as AML. The difficulties of diagnosis between AML Ph1-positive de novo and myeloid blast crisis of CML, as the first manifestation of disease, based on clinical and molecular aspects are discussed.
Serviço de Hematologia Clínica do Hospital do Servidor Público Estadual Francisco Morato de Oliveira (HSPE), São Paulo.
G W
GW
Colleoni
M
M
Satake
C L
CL
Borovik
J
J
Kerbauy
M
M
Yamamoto
D000328:Adult; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D008297:Male; D016133:Polymerase Chain Reaction; D012194:RNA-Directed DNA Polymerase; D012008:Recurrence
D012194:RNA-Directed DNA Polymerase
Leucemia mielóide aguda Ph1-positivo de novo ou crise blástica de leucemia mielóide crônica? Análise molecular e evolução clínica de um caso.