[Evidence of new diagnostic and prognostic human astrocytoma tumor markers. Potential therapeutic applications. II].
Human astrocytic tumors grow into the normal brain parenchyma either as localized tumors, or as highly diffuse neoplasms. The diffuse phenotype relates to a specific sub-type of neoplastic astrocytes with a high motility and invasion capacity. Motility features refer to locomotion while invasion features refer to protease secretion. Our data reveal that several peptides belonging to the gastrin/cholecystokinin peptide class are able to significantly (and in certain cases very significantly) modify the level of tumor growth (at the level of cell proliferation and/or cell death), of motility and of invasion in various experimental models of human astrocytic tumors. We are synthesizing various gastrin/cholecystokinin-related peptides in order to develop clinical applications with which we want to inhibit astrocytic tumor growth, individual neoplastic astrocytic motility and the invasion of the normal brain parenchyma.
Laboratoire d'Histologie, faculté de Médecine, U.L.B., Bruxelles.
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D000818:Animals; D001254:Astrocytoma / Q000628:therapy*; D014408:Biomarkers, Tumor / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000628:therapy*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005755:Gastrins / Q000627:therapeutic use*; D006801:Humans; D051379:Mice; D012844:Sincalide / Q000627:therapeutic use*
D014408:Biomarkers, Tumor; D005755:Gastrins; C013550:gastrin 17; D012844:Sincalide
Mise en évidence de nouveaux marqueurs diagnostiques and pronostiques des tumeurs astrocytaires humaines. Applications thérapeutiques potentielles. II.