[Sulbactam-ampicillin monotherapy in the ambulatory treatment of pneumonia. Results of mono-administration].
Since ampicillin, the parent drug of aminopenicillins, is hydrolyzed by penicillinase, it is normally used in association with sulbactam, a sodium penicillinate sulfone with potent inhibiting activity on type II, III, IV, and V beta-lactamases. The combination ampicillin-sulbactam has been found remarkably useful for the treatment of severe community pneumonia caused by bacteria resistant to ampicillin alone. Approximately 300 patients with community pneumonia of various degrees of severity have been treated with a single dose of 3-4 g ampicillin-sulbactam either diluted in normal saline or in dextrose solution, usually associated with methylprednisolone 20 mg or betametasone 8 mg (tapered). As assessed by clinical and radiological findings, recovery has been obtained all cases.
Natale
F
F
Servizio Sanitario Nazionale Regione Lombardia Azienda U.S.L. 21, Presidio Specialistico Extra Ospedaliero di Patologia del Torace, Mantova, Italia.
Altafini
A
A
Donno
G D
GD
Facchi
S
S
D000553:Ambulatory Care; D000667:Ampicillin / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D013902:Radiography, Thoracic; D012720:Severity of Illness Index; D013407:Sulbactam / Q000008:administration & dosage*; D016896:Treatment Outcome
D000667:Ampicillin; D013407:Sulbactam
La monoterapia con sulbactam-ampicillina nelle polmoniti trattate ambulatorialmente. I risultati della monosomministrazione.