Liposomes as drug delivery system: a strategic approach for the treatment of HIV infection.
As the number of individuals infected with human immunodeficiency virus (HIV) is growing dramatically throughout the world, it is important to develop strategies to improve the treatment of this deadly disease. It is now well established that macrophages play a central role in HIV pathogenesis, acting as reservoirs for dissemination of virus throughout the immune system. As liposomes are naturally taken up by cells of the mononuclear phagocytic system, liposome-based therapy represents a convenient approach to improve the delivery of anti-HIV agents into infected cells improving thereby the efficacy of drugs and reducing their adverse side-effects. A more specific targeting of HIV-infected cells could also be obtained by using liposomes bearing surface attached-antibodies. This review details the applications of liposomes as drug carriers for the treatment of AIDS. It also gives an overlook of the different strategies that could be explored to control the progression of the disease in infected individuals.
Désormeaux
A
A
Centre de Recherche en Infectiologie, Centre Hospitalier Universitaire de Québec, Québec, Canada.
Bergeron
M G
MG
D019380:Anti-HIV Agents / Q000008:administration & dosage*; D004337:Drug Carriers; D016503:Drug Delivery Systems; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008081:Liposomes / Q000008:administration & dosage*; D014677:Pharmaceutical Vehicles / Q000008:administration & dosage*
D019380:Anti-HIV Agents; D004337:Drug Carriers; D008081:Liposomes; D014677:Pharmaceutical Vehicles