Metastatic granulosa-cell tumor in the liver: cytopathologic findings and staining with inhibin.
Adult granulosa-cell tumor (AGCT) is an uncommon ovarian malignancy. Rarely, hepatic metastasis of this tumor may present a difficult cytologic diagnosis when such a lesion is aspirated. This case report elaborates the cytopathologic features of AGCT in the liver aspirate of a 60-yr-old woman. Correlation with histopathology and intraoperative touch-imprint cytology of the subsequent hepatic resection is also presented. The role of immunoperoxidase studies especially utilizing inhibin is also highlighted.
John K. Frost Cytopathology Laboratory, Johns Hopkins Hospital, Baltimore, Maryland 21287-6940, USA. syzali@POL.NET
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D000368:Aged; D001707:Biopsy, Needle; D002467:Cell Nucleus / Q000473:pathology; D003593:Cytoplasm / Q000473:pathology; D005260:Female; D006106:Granulosa Cell Tumor / Q000175:diagnosis / Q000473:pathology / Q000556:secondary*; D006801:Humans; D007124:Immunoenzyme Techniques; D007265:Inhibins / Q000032:analysis*; D008113:Liver Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary*; D010051:Ovarian Neoplasms / Q000473:pathology*; D013048:Specimen Handling
D007265:Inhibins