Predictors of healthy aging in men with high life expectancies.
OBJECTIVE
The purpose of this study was to identify risk factors that consistently predict staying healthy in contrast to developing clinical illness and/or physical and mental impairments.


METHODS
More than 8000 men of Japanese ancestry were followed for 28 years with repeat examinations and surveillance for deaths and incident clinical illness. Physical and cognitive functions were measured in 1993. Measures of healthy aging included surviving and remaining free of major chronic illnesses and physical and cognitive impairments.


RESULTS
Of 6505 healthy men at baseline, 2524 (39%) died prior to the final exam. Of the 3263 available survivors, 41% remained free of major clinical illnesses, 40% remained free of both physical and cognitive impairment, and 19% remained free of both illness and impairment. The most consistent predictors of healthy aging were low blood pressure, low serum glucose, not smoking cigarettes, and not being obese.


CONCLUSIONS
Beyond the biological effects of aging, much of the illness and disability in the elderly is related to risk factors present at midlife.
Buck Center for Research in Aging, Novato, Calif., USA.
D M
DM
Reed
D J
DJ
Foley
L R
LR
White
H
H
Heimovitz
C M
CM
Burchfiel
K
K
Masaki
D000368:Aged; D000375:Aging / Q000502:physiology*; D015331:Cohort Studies; D004194:Disease / Q000209:etiology; D006254:Hawaii; D015438:Health Behavior; D006801:Humans; D007564:Japan / Q000208:ethnology; D008017:Life Expectancy; D008297:Male; D001523:Mental Disorders / Q000209:etiology; D008875:Middle Aged; D011159:Population Surveillance; D012307:Risk Factors; D016019:Survival Analysis