Animal models sensitive to anti-anxiety agents.
Animal models of anxiety serve two primary purposes in psychopharmacological research. (i) The pharmacological profile observed in the model provides a basis which, depending on its predictive validity, permits an estimation of clinical activity. (ii) Insofar as the 'anxiety' occurring in the animal model is homologous to human anxiety disorders, it is possible to investigate the underlying cellular and molecular mechanisms. The most commonly used laboratory procedures for the identification of anxiolytic effects of drugs are described in this paper.
Martin
P
P
AMC Research Group, Paris, France.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001008:Anxiety Disorders / Q000139:chemically induced / Q000188:drug therapy / Q000523:psychology*; D001143:Arousal / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D006801:Humans
D014151:Anti-Anxiety Agents