Asthma and bronchial hyperresponsiveness linked to the XY long arm pseudoautosomal region.
We examined the long arm XY pseudoautosomal region for linkage to asthma, serum IgE, and bronchial hyperresponsiveness. In 57 Caucasian families multipoint nonparametric analyses provide evidence for linkage between DXYS154 and bronchial hyperresponsiveness (P = 0.000057) or asthma (P = 0.00065). This genomic region is approximately 320 kb in size and contains the interleukin-9 receptor gene. These results suggest that a gene controlling asthma and bronchial hyperresponsiveness maybe located in this region and that the interleukin-9 receptor is a potential candidate.
Magainin Institute of Molecular Medicine, Magainin Pharmaceuticals, Plymouth Meeting, Pennsylvania, 19462, USA.
K J
KJ
Holroyd
L C
LC
Martinati
E
E
Trabetti
T
T
Scherpbier
S M
SM
Eleff
A L
AL
Boner
P F
PF
Pignatti
M B
MB
Kiser
C R
CR
Dragwa
F
F
Hubbard
C D
CD
Sullivan
L
L
Grasso
C J
CJ
Messler
M
M
Huang
Y
Y
Hu
N C
NC
Nicolaides
K H
KH
Buetow
R C
RC
Levitt
D001249:Asthma / Q000235:genetics*; D016535:Bronchial Hyperreactivity / Q000235:genetics*; D002874:Chromosome Mapping; D005190:Family; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D007073:Immunoglobulin E / Q000235:genetics; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats; D018123:Receptors, Interleukin / Q000235:genetics; D014960:X Chromosome / Q000235:genetics*; D014998:Y Chromosome / Q000235:genetics*
D018123:Receptors, Interleukin; D007073:Immunoglobulin E