Human genome diversity.
Human genome diversity studies analyse genetic variation among individuals and between populations in order to understand the origins and evolution of anatomically modern humans (Homo sapiens sapiens). The availability of thousands of DNA polymorphisms (genetic markers) brings analytic power to these studies. Human genome diversity studies have clearly shown that the large part of genetic variability is due to differences among individuals within populations rather than to differences between populations, effectively discrediting a genetic basis of the concept of 'race'. Evidence from paleontology, archaeology and genetic diversity studies is quite consistent with an African origin of modern humans more than 100,000 years ago. The evidence favors migrations out of African as the source of the original peopling of Asia, Australia, Europe and Oceania. An international program for the scientific analysis of human genome diversity and of human evolution has been developed. The Human Genome Diversity Project (HGDP) aims to collect and preserve biologic samples from hundreds of populations throughout the world, make DNA from these samples available to scientists and distribute to the scientific community the results of DNA typing with hundreds of genetic markers.
Fondation Jean-Dausset, Centre d'étude du polymorphisme humain (CEPH), Paris, France. howard.cann@cephb.fr
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D019143:Evolution, Molecular; D005819:Genetic Markers; D014644:Genetic Variation; D015894:Genome, Human; D006801:Humans; D011110:Polymorphism, Genetic
D005819:Genetic Markers