Metastatic granulosa-cell tumor in the liver: cytopathologic findings and staining with inhibin.
Adult granulosa-cell tumor (AGCT) is an uncommon ovarian malignancy. Rarely, hepatic metastasis of this tumor may present a difficult cytologic diagnosis when such a lesion is aspirated. This case report elaborates the cytopathologic features of AGCT in the liver aspirate of a 60-yr-old woman. Correlation with histopathology and intraoperative touch-imprint cytology of the subsequent hepatic resection is also presented. The role of immunoperoxidase studies especially utilizing inhibin is also highlighted.
Ali
S Z
SZ
John K. Frost Cytopathology Laboratory, Johns Hopkins Hospital, Baltimore, Maryland 21287-6940, USA. syzali@POL.NET
D000368:Aged; D001707:Biopsy, Needle; D002467:Cell Nucleus / Q000473:pathology; D003593:Cytoplasm / Q000473:pathology; D005260:Female; D006106:Granulosa Cell Tumor / Q000175:diagnosis / Q000473:pathology / Q000556:secondary*; D006801:Humans; D007124:Immunoenzyme Techniques; D007265:Inhibins / Q000032:analysis*; D008113:Liver Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary*; D010051:Ovarian Neoplasms / Q000473:pathology*; D013048:Specimen Handling
D007265:Inhibins