Parainfluenza virus and respiratory syncytial virus infection in infants undergoing bone marrow transplantation for severe combined immunodeficiency.
Respiratory syncytial virus and parainfluenza virus infection carry a poor prognosis in severe combined immunodeficiency (SCID), particularly if the viral load is high. Patients with high viral load develop severe pneumonitis at engraftment which may possibly be modulated by immunotherapy, including high dose nebulised corticosteroids. Further work is required to develop effective treatment for this severe condition.
Taylor
C E
CE
Newcastle Public Health Laboratory, Newcastle General Hospital, Newcastle upon Tyne. newctayl@newphls.demon.uk
Osman
H K
HK
Turner
A J
AJ
Flood
T J
TJ
Abinun
M
M
Crooks
B
B
Cant
A J
AJ
D000998:Antiviral Agents / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D006801:Humans; D007223:Infant; D018184:Paramyxoviridae Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology; D011379:Prognosis; D018357:Respiratory Syncytial Virus Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology; D016511:Severe Combined Immunodeficiency / Q000628:therapy* / Q000821:virology; D019562:Viral Load
D000998:Antiviral Agents