Treatment of mononeuropathy multiplex in hepatitis C virus and cryoglobulinemia.
Recent reports advocate alpha-interferon (alpha-Ifn) treatment for mononeuropathy multiplex in hepatitis C virus-associated cryoglobulinemia. We report 2 patients with this disorder to describe two underrecognized treatment outcomes--worsening of polyneuropathy with initiation of alpha-Ifn, in the absence of immunosuppression, and deterioration of liver function with prednisone, despite improvement of polyneuropathy.
Scelsa
S N
SN
Department of Neurology, Beth Israel Medical Center, Albert Einstein College of Medicine, New York, New York 10003, USA.
Herskovitz
S
S
Reichler
B
B
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D000998:Antiviral Agents / Q000008:administration & dosage; D003449:Cryoglobulinemia / Q000628:therapy / Q000821:virology*; D005260:Female; D006526:Hepatitis C / Q000150:complications* / Q000628:therapy; D006801:Humans; D016898:Interferon-alpha / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000502:physiology / Q000821:virology; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy* / Q000821:virology*; D011241:Prednisone / Q000008:administration & dosage*
D000893:Anti-Inflammatory Agents; D000998:Antiviral Agents; D016898:Interferon-alpha; D011241:Prednisone