[Genetic basis of malignant melanoma].
Cytogenetic analysis has contributed significantly to defining genomic region frequently altered in malignant melanoma. In the case of 1p, 6q i 9p consistent losses or partial deletions have predicted the location of tumor suppressor genes. Recent evidence suggests that the p16 CDKN2 gene located at 9p21 is important in sporadic and familial melanoma pathogenesis.
Drewa
G
G
Katedra i Zakład Biologii, Akademii Medycznej im. Ludwika Rydygiera w Bydgoszczy.
Powierska-Czarny
J
J
D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000235:genetics; D004198:Disease Susceptibility; D016153:Genes, Suppressor; D006133:Growth Substances / Q000378:metabolism; D006801:Humans; D008545:Melanoma / Q000235:genetics*; D012878:Skin Neoplasms / Q000235:genetics*; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
D019941:Cyclin-Dependent Kinase Inhibitor p16; D006133:Growth Substances; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53
Genetyczne podłoze czerniaka złośliwego.