[Response of interleukin-6 in patients undergoing a laparoscopic or laparotomic cholecystectomy].
BACKGROUND
It is well known that surgery induces an acute inflammatory response associated with significant increase of interleukin-6 (IL-6) and C reactive protein (CRP). Laparoscopic cholecystectomy (LC) is a so called "mini-invasive" surgical intervention and on the basis of this consideration it has been investigated if and how serological markers of inflammation are modified in patients after laparoscopic cholecystectomy compared to patients undergoing open cholecystectomy.


METHODS
The acute phase of inflammation (IL-6, CRP and body temperature) was evaluated in 53 patients one day before surgery and p.o. after 1, 3 and 6 days; 26 patients underwent "open" cholecystectomy and 27 LC.


RESULTS
One day after surgery patients with open cholecystectomy showed significant increase (p < 0.05) of IL-6, CRP and body temperature, while these parameters were almost unchanged in patients with LC. In patients with "open" cholecystectomy, 2 p.o. complications (pneumonia) were observed.


CONCLUSIONS
In conclusion, LC, although it requires longer operative time, strongly reduces p.o. pain, hospitalization, promotes earlier recovery and return to normal activity, avoiding the acute phase of p.o. inflammation with better p.o. morbidity compared to open surgery.
Divisione di Discipline Chirurgiche, Cattedra di Chirurgia Generale II, Università degli Studi, L'Aquila.
M
M
Schietroma
A
A
Risetti
F
F
Carlei
G
G
Maggi
G
G
Cianca
C
C
De Santis
D
D
Centi
D
D
Iannucci
C L
CL
Recchia
S
S
Mattucci
M
M
Simi
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000378:metabolism; D002763:Cholecystectomy; D017081:Cholecystectomy, Laparoscopic; D005260:Female; D005334:Fever / Q000097:blood; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D007813:Laparotomy; D008297:Male; D008875:Middle Aged
D015850:Interleukin-6; D002097:C-Reactive Protein
Risposta della interleukina-6 in pazienti sottoposti a colecistectomia laparoscopica o laparotomica.