Evidence of apoptosis induced by myocardial ischemia: A case of ventricular septal rupture following acute myocardial infarction.
Recent studies have reported that apoptosis may be induced by reperfusion injury following ischemia in cardiomyocytes. We present a case with evidence of apoptosis induced by myocardial ischemia without reperfusion. DNA fragmentation was demonstrated in the nuclei of the myocardial cells surrounding the ventricular septal rupture following acute myocardial infarction without reperfusion in the infarct-related left anterior descending coronary artery. This finding suggests that ischemia without reperfusion may induce apoptosis in myocardial cells.
Department of Surgery, Division II, Kobe University School of Medicine, Kobe, Japan.
Y
Y
Toyoda
T
T
Shida
N
N
Wakita
N
N
Ozaki
R
R
Takahashi
M
M
Okada
D000368:Aged; D017209:Apoptosis / Q000235:genetics; D006328:Cardiac Catheterization; D006348:Cardiac Surgical Procedures; D017023:Coronary Angiography; D053938:DNA Fragmentation; D004452:Echocardiography; D005500:Follow-Up Studies; D006346:Heart Septum / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging / Q000473:pathology; D012422:Rupture, Spontaneous