Necrotizing toxoplasmic encephalitis in a child with the X-linked hyper-IgM syndrome.
We report on a 9-year-old boy with the hyper-IgM syndrome who presented with rapid impairment of consciousness. The brain CT scan showed multiple round lucencies, and the brain histology revealed necrotizing toxoplasmic encephalitis. This patient, whose CD40/CD40 ligand system was impaired, indicates the importance of this system for defence against toxoplasmic infection.


CONCLUSIONS
Although disseminated toxoplasmosis is a rare complication of the hyper-IgM syndrome, it must be included in the differential diagnosis of infections.
Department of Paediatrics, Nagoya University School of Medicine, Japan.
I
I
Tsuge
H
H
Matsuoka
A
A
Nakagawa
Y
Y
Kamachi
K
K
Aso
T
T
Negoro
M
M
Ito
S
S
Torii
K
K
Watanabe
D002648:Child; D004660:Encephalitis / Q000175:diagnosis / Q000209:etiology*; D008040:Genetic Linkage; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications* / Q000235:genetics; D007075:Immunoglobulin M / Q000097:blood*; D008297:Male; D009336:Necrosis; D012730:Sex Chromosomes; D014123:Toxoplasmosis / Q000175:diagnosis / Q000209:etiology*
D007075:Immunoglobulin M