Cobalamin-dependent methionine synthase and serine hydroxymethyltransferase: targets for chemotherapeutic intervention?
Chemotherapeutic drugs targeted at folate-dependent reactions have typically been directed at a limited number of target enzymes: dihydrofolate reductase, thymidylate synthase, and GAR and AICAR transformylase. This review discusses two other potential targets for chemotherapeutic inhibition: cobalamin-dependent methionine synthase and serine hydroxymethyltransferase. Brief reviews of the catalytic properties of these two enzymes are presented, and possible strategies for chemotherapeutic intervention are discussed.
Matthews
R G
RG
Biophysics Research Division, University of Michigan, Ann Arbor 41809-1055, USA.
Drummond
J T
JT
Webb
H K
HK
D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / Q000037:antagonists & inhibitors*; D000241:Adenosine / Q000031:analogs & derivatives / Q000494:pharmacology; D015195:Drug Design; D004358:Drug Therapy; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D012696:Glycine Hydroxymethyltransferase / Q000037:antagonists & inhibitors*; D006801:Humans; D007700:Kinetics; D015394:Molecular Structure; D013912:Threonine / Q000031:analogs & derivatives / Q000378:metabolism; D014155:Transcobalamins / Q000378:metabolism
D004791:Enzyme Inhibitors; D014155:Transcobalamins; D013912:Threonine; D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; D012696:Glycine Hydroxymethyltransferase; D000241:Adenosine; C006235:sinefungin