Translocation (1;22) in refractory anemia and the prognostic significance of karyotypic abnormalities in refractory anemia.
The most common cytogenetic abnormalities associated with myelodysplastic syndromes are deletions of chromosomes 5 and 7 and trisomy 8. Reciprocal translocation is relatively uncommon in refractory anemia. We describe a case of refractory anemia associated with trisomy 8 and a derivative chromosome 22 resulting from t(1;22)(q11;q11.2). The diseases and the role of the various genes that are mapped to these breakpoints are discussed. The prognostic significance of karyotypic abnormalities in refractory anemia are reviewed.
Keung
Y K
YK
Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock 79430, USA.
Cobos
E
E
Tonk
V
V
Morgan
D
D
D000368:Aged; D000753:Anemia, Refractory / Q000235:genetics*; D002878:Chromosomes, Human, Pair 1; D002892:Chromosomes, Human, Pair 22; D005260:Female; D006801:Humans; D007621:Karyotyping; D011379:Prognosis; D014178:Translocation, Genetic