An increase in [3H] CGS21680 binding in the striatum of postmortem brains of chronic schizophrenics.
We measured adenosine 2a receptors in basal ganglia of 13 schizophrenics and 10 controls, using [3H] CGS21680 as a ligand for the receptor binding assay. There was a significant increase in the specific [3H] CGS21680 binding in the putamen and caudate, but not in the globus pallidus of externa, of the schizophrenic patients, compared to those of controls. These results provide evidence suggesting that adenosine 2a receptors play a role in the pathophysiology of schizophrenia.
Kurumaji
A
A
Department of Neuropsychiatry, Tokyo Medical and Dental University School of Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan. 0724.pysc@med.tmd.ac.jp
Toru
M
M
D000241:Adenosine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000378:metabolism / Q000494:pharmacology*; D001923:Brain Chemistry / Q000502:physiology; D002908:Chronic Disease; D003342:Corpus Striatum / Q000737:chemistry*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010627:Phenethylamines / Q000378:metabolism / Q000494:pharmacology*; D011869:Radioligand Assay; D018341:Receptors, Adrenergic, alpha-2 / Q000032:analysis* / Q000378:metabolism; D012559:Schizophrenia / Q000378:metabolism*; D014316:Tritium
D000959:Antihypertensive Agents; D010627:Phenethylamines; D018341:Receptors, Adrenergic, alpha-2; D014316:Tritium; C061282:2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine; D000241:Adenosine