Biologic activities of IL-1 and its role in human disease.
The role of the polypeptide proinflammatory cytokine IL-1 family represents a group of proteins that have contrasting and synergistic biologic responses. IL-1alpha and beta and their precursor forms are heavily involved in the enhancement of inflammation and host defense. Within this family of gene products, there is also a naturally occurring receptor antagonist, IL-1ra, as well as a family of receptor proteins that have differential signaling functions and activities. The study of these proteins in human disease, including allergic disease and type 1 hypersensitivity responses, has led to a better understanding of the underlying general inflammation associated with these syndromes and has provided opportunities to look at new forms of intervention in allergic disease and asthma.
Rosenwasser
L J
LJ
Division of Allergy and Clinical Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, USA.
D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D006969:Hypersensitivity, Immediate / Q000276:immunology*; D007375:Interleukin-1 / Q000276:immunology*; D011487:Protein Conformation; D013329:Structure-Activity Relationship
D007375:Interleukin-1