Renal dysfunction after total knee replacement is not aggravated by bone cement.
BACKGROUND
Total knee replacement (TKR) has been associated with postoperative renal dysfunction. The use of monomeric methylmethacrylate (MMA) bone cement causes hypotension by several mechanisms.


METHODS
In 30 patients undergoing TKR with (n = 16), or without (n = 14) bone cement, serum levels of creatinine, cystatin C and creatine kinase (CK) and urinary levels of creatinine and markers for glomerular (albumin, IgG) and tubular (protein HC) function were recorded preoperatively and on days 1, 2, 4 and 8 postoperatively.


RESULTS
There were no changes in serum creatinine. Both groups had a transient, 5-fold rise in CK and a continuous increase in cystatin C. The urinary concentration of proteins increased postoperatively with a peak in the glomerular markers on day 1 and in the tubular marker on day 2. There were no significant differences in proteinuria between the groups. The 95% CIs for the difference in the means of the AUCs of the logarithmically transformed values for the proteins were never more than 19%. On day 8 all proteins had returned to their preoperative levels.


CONCLUSIONS
Postoperatively, there was a transient increased leakage of proteins, indicating glomerular and tubular dysfunction. This was not influenced by the use of MMA bone cement.
Nergelius
G
G
Department of Anesthesia and Intensive Care, University Hospital, Lund, Sweden.
Lidgren
L
L
Grubb
A
A
Vinge
E
E
D000368:Aged; D000369:Aged, 80 and over; D000419:Albuminuria / Q000139:chemically induced; D019540:Area Under Curve; D019645:Arthroplasty, Replacement, Knee; D001843:Bone Cements / Q000009:adverse effects*; D003404:Creatinine / Q000652:urine; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000652:urine; D008297:Male; D008768:Methylmethacrylates / Q000009:adverse effects*; D008875:Middle Aged; D011183:Postoperative Complications / Q000139:chemically induced* / Q000652:urine; D011507:Proteinuria / Q000139:chemically induced
D001843:Bone Cements; D008768:Methylmethacrylates; D003404:Creatinine