Functional MR spectroscopy of the brain.
Functional MR spectroscopy is a technique for measuring brain activation that is based on metabolic changes in MR spectroscopy-detectable metabolites. This article covers functional MR spectroscopy applications in visual stimulation, auditory stimulation, language activation, cerebral metabolic rate, water MR spectroscopy, and in psychiatric disorders. Functional MR spectroscopy offers the ability to measure changes in the brain during neuronal activation that may be a more direct measure of cellular activation than functional magnetic resonance imaging. MR spectroscopy-detectable chemicals that are currently of greatest interest for measuring brain activation are also discussed.
Richards
T L
TL
Department of Radiology, University of Washington, Seattle 98195, USA. toddr@u.washington.edu
Dager
S R
SR
Posse
S
S
D000161:Acoustic Stimulation; D001921:Brain / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007802:Language; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D010775:Photic Stimulation