[Apolipoprotein B and LDL cholesterol: which parameter(s) should be included in the assessment of cardiovascular risk?].
High level of plasma apo B lipoproteins is a risk factor for coronary artery disease. However, which lipid parameters should be routinely assayed is a question still in debate. For this purpose, the authors have studied issues since 1992 comparing predictive and discriminative values of LDL-cholesterol and apo B in order to assess coronary artery disease. Indeed the respective advantages of these markers were still being discussed after an exhaustive review had been completed in 1992. Despite the number of the debates, none of the few studies about this topic rise any decisive arguments. In conclusion it is proposed that a true comparison of the predictive values of LDL-cholesterol and apo B should be carried out before making definitive recommendations concerning their clinical utility.
Service de biochimie, Hôpital Tenon, Paris.
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S
Bloch
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R
Couderc
D001055:Apolipoproteins B / Q000097:blood*; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology* / Q000517:prevention & control; D008078:Cholesterol, LDL / Q000097:blood*; D003327:Coronary Disease / Q000097:blood / Q000453:epidemiology* / Q000517:prevention & control; D005260:Female; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D012307:Risk Factors
D001055:Apolipoproteins B; D008078:Cholesterol, LDL
Apolipoprotéine B et cholestérol des LDL: quel(s) paramètre(s) inclure dans l'appréciation du risque cardiovasculaire?