Microvascular pathophysiology of skeletal muscle ischemia-reperfusion.
Ischemia-reperfusion injury is a continuing challenge to vascular surgeons. Microvascular factors and mechanisms underlying edema and compartment syndrome provide a useful end point for analysis and planning of therapy. We review the pivotal role of endothelium-leukocyte interactions and of cytokines in the genesis of postischemic damage in muscle. Clinical considerations and future directions based on research and practice are presented.
Department of Pharmacology, UMDNJ-New Jersey Medical School, Newark 07103-2714, USA.
W N
WN
Durán
H
H
Takenaka
R W
RW
Hobson
D000208:Acute Disease; D000818:Animals; D002199:Capillary Permeability; D004730:Endothelium, Vascular / Q000503:physiopathology; D005121:Extremities / Q000098:blood supply; D006801:Humans; D018482:Muscle, Skeletal / Q000098:blood supply* / Q000473:pathology; D009131:Muscle, Smooth, Vascular / Q000503:physiopathology; D009504:Neutrophils / Q000502:physiology; D015427:Reperfusion Injury / Q000473:pathology / Q000503:physiopathology*; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D014409:Tumor Necrosis Factor-alpha