Integrins during muscle development and in muscular dystrophies.
Cellular interactions with the extracellular matrix (ECM) have been shown to be important for a number of developmental events from the time of fertilization up till the maturation of the organism. In the following review we will discuss what is currently known about these interactions with special emphasis on the role of integrins during the formation of skeletal muscle. The importance of cell-ECM interactions will also be illustrated by a discussion of what happens when these interactions go awry, as happens in muscular dystrophies.
Gullberg
D
D
Department of Animal Physiology, Uppsala University, BMC, Box 596, S-751 24 Uppsala, Sweden.
Velling
T
T
Lohikangas
L
L
Tiger
C F
CF
D000818:Animals; D002465:Cell Movement; D005109:Extracellular Matrix / Q000502:physiology; D005355:Fibrosis / Q000503:physiopathology; D006801:Humans; D016023:Integrins / Q000502:physiology*; D018482:Muscle, Skeletal / Q000196:embryology*; D009136:Muscular Dystrophies / Q000503:physiopathology*; D009137:Muscular Dystrophy, Animal / Q000503:physiopathology; D011956:Receptors, Cell Surface / Q000502:physiology; D012038:Regeneration; D015398:Signal Transduction
D016023:Integrins; D011956:Receptors, Cell Surface