Bioavailability of rifampicin, isoniazid and pyrazinamide from fixed-dose combination capsules.
METHODS
The absorption of rifampicin, isoniazid and pyrazinamide was tested after administration of each drug in free combinations and in a fixed-dose combination of the three drugs, known as Trifazid.


OBJECTIVE
To examine the relative bioavailability of rifampicin, isoniazid and pyrazinamide after oral administration of the drugs given alone in comparison to that of the same drugs after administration of Trifazid.


METHODS
An open, randomized, cross-over study comprising 16 healthy volunteers.


RESULTS
The pattern of absorption, plasma concentrations and pharmacokinetic parameters were very similar after administration of the drugs in free and fixed combinations.


CONCLUSIONS
The triple combination of antituberculosis drugs could replace the separate drugs in the treatment of tuberculosis.
Zwolska
Z
Z
National Research Institute of Tuberculosis and Lung Diseases, Warsaw, Poland.
Niemirowska-Mikulska
H
H
Augustynowicz-Kopec
E
E
Walkiewicz
R
R
Stambrowska
H
H
Safianowska
A
A
Grubek-Jaworska
H
H
D000284:Administration, Oral; D000328:Adult; D000904:Antibiotics, Antitubercular / Q000008:administration & dosage / Q000097:blood*; D001682:Biological Availability; D018592:Cross-Over Studies; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011718:Pyrazinamide / Q000008:administration & dosage / Q000097:blood*; D012016:Reference Values; D012293:Rifampin / Q000008:administration & dosage / Q000097:blood*
D000904:Antibiotics, Antitubercular; D004338:Drug Combinations; C087181:isoniazid, pyrazinamide, rifampin drug combination; D011718:Pyrazinamide; D007538:Isoniazid; D012293:Rifampin