Pharmacokinetics and oral bioavailability of glycopyrrolate in children.
Based on plasma levels determined with a radioreceptor assay and following a single oral (50 micrograms/kg) and intravenous (5 micrograms/kg) administration of glycopyrrolate in six healthy children operated twice during a several weeks period, a negligible and variable oral bioavailability was found (3.3; 1.3-13.3%) (median;range). No significant changes in heart rate after oral or intravenous administration of the drug could be seen. Oral glycopyrrolate appears to have no place in paediatric premedication.
Rautakorpi
P
P
Department of Anaesthesiology, Turku University Hospital, Finland.
Manner
T
T
Ali-Melkkilä
T
T
Kaila
T
T
Olkkola
K
K
Kanto
J
J
D000759:Adjuvants, Anesthesia / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D000284:Administration, Oral; D000293:Adolescent; D001682:Biological Availability; D002648:Child; D005260:Female; D006024:Glycopyrrolate / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D013511:Minor Surgical Procedures
D000759:Adjuvants, Anesthesia; D006024:Glycopyrrolate