Two-staged resection of a left frontal astrocytoma involving the operculum and insula using intraoperative neurophysiological monitoring--case report.
A 29-year-old right-handed male with a 12-year education presented with a 2-month history of generalized epileptic activity. Neuroradiological imaging demonstrated a large lesion in the left frontal lobe involving the insulooperculum and in the temporal tip. Neurological and neuropsychological examination revealed no abnormality. Two-staged total resection of a left frontal large astrocytoma involving the insulooperculum was achieved, with preservation of the speech and motor functions. The prefrontal area was resected en bloc under general anesthesia. To avoid vascular damage including the lenticulostriate arteries, the sylvian and the interhemispheric fissures were thoroughly opened. The tumor was apparently located in the anatomical Broca's area. Eighteen days later, the residual tumor was totally resected with no language deficit after identifying the motor-speech cortex, which was displaced from the usual location, by direct cortical stimulation under local anesthesia. The medially extended insular tumor was then resected stepwise with frequent neurological monitoring with the patient awake. Surgery for intraaxial insuloopercular lesions in the dominant hemisphere carries a high risk of speech and motor deficit. This staged operation enables maximum tumor resection of dominant-side large frontal gliomas involving the insuloopercular region, with preservation of both motor and speech functions.
Department of Neurosurgery, Tohoku University School of Medicine, Sendai.
T
T
Kumabe
N
N
Nakasato
K
K
Suzuki
K
K
Sato
Y
Y
Sonoda
J
J
Kawagishi
T
T
Yoshimoto
D000328:Adult; D001931:Brain Mapping / Q000379:methods; D001932:Brain Neoplasms / Q000175:diagnosis / Q000601:surgery*; D002540:Cerebral Cortex / Q000503:physiopathology; D017024:Chemotherapy, Adjuvant; D003399:Craniotomy / Q000379:methods*; D004558:Electric Stimulation; D005625:Frontal Lobe / Q000601:surgery; D005909:Glioblastoma / Q000175:diagnosis / Q000601:surgery*; D006801:Humans; D008297:Male; D016343:Monitoring, Intraoperative / Q000379:methods*; D009483:Neuropsychological Tests; D018714:Radiotherapy, Adjuvant; D012086:Reoperation; D013702:Temporal Lobe / Q000601:surgery; D016896:Treatment Outcome