Antineoplastic and cytogenetic effects of platinum(II) and palladium(II) complexes with pyridine-2-carboxyaldehyde-thiosemicarbazone.
The effect of six novel complexes of Pt(II) and Pd(II) with pyridine-2-carboxyaldehyde thiosemicarbazone (HPyTsc) on sister chromatid exchange rate and human lymphocyte proliferation kinetic was studied. Also, the effect of Pt(II) and Pd(II) complexes against leukemia P388 was investigated. Among these compounds, the most effective in inducing cytogenetic and antineoplastic effects are the complexes [Pd(PyTsc)2] and [Pt(PyTsc)2]. Next in order of magnitude in inducing antineoplastic and cytogenetic effects is the compound [Pt(HPyTsc)2]Cl2 while the rest, i.e. [Pd(PyTsc)Cl], HPyTsc, [Pd(HPyTsc)2]Cl2, and [Pt(PyTsc)Cl], show marginal cytogenetic and antineoplastic effects.
Inorganic and Analytical Chemistry, Department of Chemistry, University of Ioannina, Ioannina, Greece. dkovala@cc.uoi.gr
D
D
Kovala-Demertzi
M A
MA
Demertzis
V
V
Varagi
A
A
Papageorgiou
D
D
Mourelatos
E
E
Mioglou
Z
Z
Iakovidou
A
A
Kotsis
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007941:Leukemia P388 / Q000188:drug therapy; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009942:Organometallic Compounds / Q000494:pharmacology*; D009944:Organoplatinum Compounds / Q000494:pharmacology*; D010165:Palladium / Q000737:chemistry / Q000494:pharmacology*; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D013882:Thiosemicarbazones / Q000737:chemistry / Q000494:pharmacology*
D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D009944:Organoplatinum Compounds; D013882:Thiosemicarbazones; C013996:2-formylpyridine thiosemicarbazone; D010165:Palladium