Transdermal alniditan delivery by skin electroporation.
The aim of this study was to evaluate the transdermal permeation of alniditan by electroporation and to compare with iontophoretic delivery. The influence of the electrical parameters of electroporation was investigated in vitro using a factorial design study. The transdermal flux of alniditan was enhanced by two orders of magnitude by application of high voltage electrical pulses. The electrical parameters of electroporation-i.e. the voltage, the duration and the number of pulses-allowed a control of drug permeation. Both transport during and after pulsing were shown to be important for alniditan transdermal delivery by electroporation. Electroporation was found more efficient in promoting alniditan permeation than an iontophoresis transferring the same amount of charges.
Université catholique de Louvain, Unité de pharmacie galénique, Brussels, Belgium.
A
A
Jadoul
N
N
Lecouturier
J
J
Mesens
W
W
Caers
V
V
Préat
D000279:Administration, Cutaneous; D000818:Animals; D001578:Benzopyrans / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D004058:Diffusion; D018274:Electroporation; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007478:Iontophoresis; D016014:Linear Models; D008297:Male; D011437:Propylamines / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D011743:Pyrimidines / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D051381:Rats; D004561:Transcutaneous Electric Nerve Stimulation; D014662:Vasoconstrictor Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*
D001578:Benzopyrans; D011437:Propylamines; D011743:Pyrimidines; D014662:Vasoconstrictor Agents; C100822:alniditan