Remifentanil and tramadol.
The lack of analgesic efficacy limits tramadol as a sole agent to treat severe pain after surgery. However, it has a relative lack of respiratory depressant and constipating effects compared with morphine and codeine, and does not share the propensity of nonsteroidal anti-inflammatory drugs to provoke asthma, gastrointestinal mucosal damage and renal impairment. It may well have a place in the management of pain after surgery, in combination with another drug, such as paracetamol, or after control of the worst of pain after surgery by a regional local anaesthetic technique.
Department of Anaesthesia, University of Leicester, Glenfield Hospital.
D J
DJ
Duthie
D000701:Analgesics, Opioid / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D010880:Piperidines / Q000493:pharmacokinetics / Q000494:pharmacology*; D000077208:Remifentanil; D014147:Tramadol / Q000009:adverse effects / Q000494:pharmacology*
D000701:Analgesics, Opioid; D010880:Piperidines; D014147:Tramadol; D000077208:Remifentanil