Genetic diagnostic test of hepatocellular carcinoma by telomerase catalytic subunit mRNA.
This study investigated the relationship between telomerase activity and telomere length and between telomerase reverse transcriptase (hTERT) mRNA and telomere length. Both cancerous and non-cancerous tissues were studied in individuals with hepatic carcinoma. In this study, the telomere length in HCC livers had a wide range, no clear significant correlation was found between hTERT mRNA and telomere length. Telomerase activity was more strongly correlated with hTERT mRNA than with telomere length. The correlation between hTERT mRNA and telomerase activity shown here indicates that hTERT mRNA has potential for cancer diagnosis.
Center for Molecular Biology and Cytogenetics, SRL, Tokyo 191-0002, Japan.
E
E
Wada
H
H
Hisatomi
T
T
Moritoyo
T
T
Kanamaru
K
K
Hikiji
D000328:Adult; D001707:Biopsy, Needle; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D046911:Macromolecular Substances; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000032:analysis* / Q000235:genetics; D019098:Telomerase / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D016615:Telomere / Q000235:genetics* / Q000648:ultrastructure
D046911:Macromolecular Substances; D012333:RNA, Messenger; D019098:Telomerase