[Disturbance of the normal cell cycle by T antigens of SV40 viruses and JC cause some tumors].
The mechanism that may lead to tumor formation in SV40 or JCV infected tissues based on previously reported interactions between T antigens and two factors (p53 and pRb) controlling cell cycle has been discussed. p53 is a known tumor suppressor protein that delays S phase entry causing cell arrest in G1 phase or apoptosis when the DNA damage occurs. Phosphorylation of pRB releases E2F family proteins that activate genes encoding S phase promoting factors. Binding of T antigens to pRB induces tumor formation, whereas tumor proliferation requires knockout of p53 activity.
Kryńska
B
B
Center for NeuroVirology and NeuroOncology, Allegheny University of the Health Sciences, Philadelphia, USA.
Lewin-Kowalik
J
J
Sieroń
A L
AL
D000818:Animals; D000952:Antigens, Polyomavirus Transforming / Q000276:immunology*; D002453:Cell Cycle / Q000235:genetics; D004273:DNA, Neoplasm / Q000032:analysis; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007577:JC Virus / Q000276:immunology*; D009369:Neoplasms / Q000473:pathology* / Q000821:virology*; D013539:Simian virus 40 / Q000276:immunology*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D000952:Antigens, Polyomavirus Transforming; D004273:DNA, Neoplasm; D016159:Tumor Suppressor Protein p53