Transformation of tooth type induced by inhibition of BMP signaling.
Mammalian dentitions are highly patterned, with different types of teeth positioned in different regions of the jaws. BMP4 is an early oral epithelial protein signal that directs odontogenic gene expression in mesenchyme cells of the developing mandibular arch. BMP4 was shown to inhibit expression of the homeobox gene Barx-1 and to restrict expression to the proximal, presumptive molar mesenchyme of mouse embryos at embryonic day 10. The inhibition of BMP signaling early in mandible development by the action of exogenous Noggin protein resulted in ectopic Barx-1 expression in the distal, presumptive incisor mesenchyme and a transformation of tooth identity from incisor to molar.
Tucker
A S
AS
Department of Craniofacial Development, Guy's, King's, and St. Thomas' School of Dentistry, Guy's Hospital, London SE1 9RT, UK.
Matthews
K L
KL
Sharpe
P T
PT
D000818:Animals; D019521:Body Patterning; D055415:Bone Morphogenetic Protein 4; D019485:Bone Morphogenetic Proteins / Q000502:physiology*; D002352:Carrier Proteins; D046508:Culture Techniques; D018507:Gene Expression Regulation, Developmental; D005801:Genes, Homeobox; D018398:Homeodomain Proteins / Q000235:genetics* / Q000502:physiology; D007180:Incisor / Q000196:embryology*; D051957:MSX1 Transcription Factor; D008297:Male; D008334:Mandible / Q000196:embryology; D008648:Mesoderm / Q000378:metabolism / Q000637:transplantation; D051379:Mice; D008963:Molar / Q000196:embryology*; D009805:Odontogenesis; D015513:Oncogene Proteins / Q000235:genetics; D011506:Proteins / Q000378:metabolism / Q000494:pharmacology; D015398:Signal Transduction; D014083:Tooth Germ / Q000196:embryology; D014157:Transcription Factors / Q000235:genetics*; D000099176:Noggin Protein
D055415:Bone Morphogenetic Protein 4; D019485:Bone Morphogenetic Proteins; D002352:Carrier Proteins; D018398:Homeodomain Proteins; D051957:MSX1 Transcription Factor; D015513:Oncogene Proteins; D011506:Proteins; D014157:Transcription Factors; D000099176:Noggin Protein; C490667:BARX1 protein, human; C095587:Barx1 protein, mouse; C525810:Bmp4 protein, mouse; C487378:Tlx1 protein, mouse