Suicide attempts with mirtazapine overdose without complications.
BACKGROUND
One important aim of pharmacotherapy in depressed patients is the prevention of suicide attempts. Therefore, the medication given should be efficient and safe in overdose.


RESULTS
We saw two patients after they had overdosed with mirtazapine because of suicidal intention. Both patients had taken 30 and 50 times a normal daily dose and achieved a full recovery without any complications or harm.


CONCLUSIONS
Mirtazapine seems to be a safe compound in overdose. Therefore, it is an important therapeutic agent in depressed and suicidal patients.
Holzbach
R
R
Department of Psychiatry and Psychotherapy, University of Hamburg, Germany.
Jahn
H
H
Pajonk
F G
FG
Mähne
C
C
D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects*; D003866:Depressive Disorder / Q000188:drug therapy*; D062787:Drug Overdose; D005260:Female; D006801:Humans; D008803:Mianserin / Q000009:adverse effects / Q000031:analogs & derivatives*; D008875:Middle Aged; D000078785:Mirtazapine; D013406:Suicide, Attempted; D000092864:Suicide Prevention
D000929:Antidepressive Agents, Tricyclic; D008803:Mianserin; D000078785:Mirtazapine