title: Metaiodobenzylguanidine and heart rate variability in heart failure.
abstract: It is assumed that the low-frequency power (LF) of heart rate variability (HRV) increases with progress of congestive heart failure (CHF), therefore positively correlating with cardiac 123I-metaiodobenzylguanidine (MIBG) washout. It is demonstrated here that HRV, including normalized LF, correlated inversely with MIBG washout and positively with the ratio of heart-to-mediastinum MIBG activity in controls and CHF patients, whereas these correlations were not observed within CHF patients. Thus MIBG washout may increase and HRV including normalized LF may decrease with CHF, although the HRV and MIBG measures may not similarly change in proportion to the severity of the cardiac autonomic dysfunction in CHF.
authors.affiliation: Department of Medicine III, Hamamatsu University School of Medicine, Japan. kurata-c@post.yamaha.co.jp
authors.forename: C
authors.initials: C
authors.lastname: Kurata
authors.forename: S
authors.initials: S
authors.lastname: Shouda
authors.forename: T
authors.initials: T
authors.lastname: Mikami
authors.forename: A
authors.initials: A
authors.lastname: Uehara
authors.forename: K
authors.initials: K
authors.lastname: Ishikawa
authors.forename: K
authors.initials: K
authors.lastname: Tawarahara
authors.forename: T
authors.initials: T
authors.lastname: Nakano
authors.forename: F
authors.initials: F
authors.lastname: Matoh
authors.forename: K
authors.initials: K
authors.lastname: Takeuchi
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006333:Heart Failure / Q000378:metabolism / Q000503:physiopathology*; D006339:Heart Rate; D006801:Humans; D007457:Iodine Radioisotopes / Q000378:metabolism / Q000493:pharmacokinetics; D007462:Iodobenzenes / Q000378:metabolism* / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged
chemical_list: D007457:Iodine Radioisotopes; D007462:Iodobenzenes