title: [Acid esophago-pharyngeal reflux as etiology of hoarseness].
abstract: BACKGROUND
  Gastroesophageal reflux has been implicated in otolaryngologic problems, particularly chronic hoarseness that cannot be attributed to other causes.
  
  
  METHODS
  To study this relationship between gastroesophageal reflux and chronic hoarseness we used 24-h dual-site ambulatory pH-recordings in 68 patients with chronic hoarseness and laryngeal lesions suggestive of acid irritation.
  
  
  RESULTS
  Thirty-eight patients (56%) had evidence of at least one esophago-pharyngeal reflux episode. The mean number of esophago-pharyngeal episodes was 6.7 +/- 12 within 24 hours (range: 1-34 episodes). The mean duration of these episodes was 201 +/- 28 seconds (range: 6 seconds-19.6 minutes). Most patients with esophago-pharyngeal reflux had no evidence of pathologic gastroesophageal reflux. Only 28.9% of the patients with esophago-pharyngeal reflux episodes also had pathologic gastroesophageal phageal reflux, whereas 23.3% of the patients without esophago-pharyngeal reflux had no gastroesophageal reflux disease. The esophago-pharyngeal reflux occurred mainly in the upright position.
  
  
  CONCLUSIONS
  Occult esophago-pharyngeal reflux, predominantly in the upright position, appears to be common and severe in patients with chronic hoarseness. Gastroesophageal reflux may be an important factor in the pathogenesis of chronic hoarseness. The causative mechanisms are not clear.
authors.affiliation: Medizinische Klinik, Ferdinand-Sauerbruch-Klinikum Wuppertal.
authors.forename: G H
authors.initials: GH
authors.lastname: Micklefield
authors.forename: H J
authors.initials: HJ
authors.lastname: Radü
authors.forename: I
authors.initials: I
authors.lastname: Greving
authors.forename: B
authors.initials: B
authors.lastname: May
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D004942:Esophagitis, Peptic / Q000150:complications / Q000175:diagnosis; D005260:Female; D005745:Gastric Acidity Determination; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000175:diagnosis; D006685:Hoarseness / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D011187:Posture