title: Central diabetes insipidus with spontaneous remission. A case report.
abstract: We report a case of central diabetes insipidus with spontaneous remission 8 months after clinical beginning of the disease. A 20 years-old man developed polydipsia and polyuria in October 1994. A water deprivation study showed a defect in the urine concentrating function, which was corrected by vasopressine. A Magnetic Resonance imaging of the skull revealed a thickening of the pituitary stalk. His condition was well controlled by nasal DDAVP administration and 6 months later patient reduced spontaneously medication dose without clinical worsening. 8 months after clinical beginning, patient has become completely free from the need for medication to control clinical symptoms and urine concentrating function, as demonstrated by a re-evaluation study with water deprivation. A control Magnetic Resonance showed the regression of stalk enlargement. The clinical and radiological features of this case are discussed.
authors.affiliation: Cattedra di Medicina Interna (OPD), Istituto di Patologia Medica, Università, Siena.
authors.forename: G
authors.initials: G
authors.lastname: Martini
authors.forename: G
authors.initials: G
authors.lastname: Filosomi
authors.forename: R
authors.initials: R
authors.lastname: Valenti
authors.forename: S
authors.initials: S
authors.lastname: Lunghetti
authors.forename: D
authors.initials: D
authors.lastname: Pallavicino
authors.forename: R
authors.initials: R
authors.lastname: Nuti
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology; D003919:Diabetes Insipidus / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011141:Polyuria / Q000188:drug therapy / Q000209:etiology; D012075:Remission, Spontaneous; D012076:Renal Agents / Q000627:therapeutic use; D014667:Vasopressins / Q000627:therapeutic use
chemical_list: D012076:Renal Agents; D014667:Vasopressins