Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum.
Chromosome 2 of Plasmodium falciparum was sequenced; this sequence contains 947,103 base pairs and encodes 210 predicted genes. In comparison with the Saccharomyces cerevisiae genome, chromosome 2 has a lower gene density, introns are more frequent, and proteins are markedly enriched in nonglobular domains. A family of surface proteins, rifins, that may play a role in antigenic variation was identified. The complete sequencing of chromosome 2 has shown that sequencing of the A+T-rich P. falciparum genome is technically feasible.
Gardner
M J
MJ
Institute for Genomic Research, Rockville, MD 20850, USA.
Tettelin
H
H
Carucci
D J
DJ
Cummings
L M
LM
Aravind
L
L
Koonin
E V
EV
Shallom
S
S
Mason
T
T
Yu
K
K
Fujii
C
C
Pederson
J
J
Shen
K
K
Jing
J
J
Aston
C
C
Lai
Z
Z
Schwartz
D C
DC
Pertea
M
M
Salzberg
S
S
Zhou
L
L
Sutton
G G
GG
Clayton
R
R
White
O
O
Smith
H O
HO
Fraser
C M
CM
Adams
M D
MD
Venter
J C
JC
Hoffman
S L
SL
D000595:Amino Acid Sequence; D000818:Animals; D000953:Antigens, Protozoan / Q000737:chemistry / Q000235:genetics; D001482:Base Composition; D002875:Chromosomes / Q000235:genetics*; D019143:Evolution, Molecular; D017125:Genes, Protozoan; D018503:Genome, Protozoan; D007438:Introns; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics; D008969:Molecular Sequence Data; D005810:Multigene Family; D020161:Physical Chromosome Mapping; D010963:Plasmodium falciparum / Q000235:genetics*; D015800:Protozoan Proteins / Q000737:chemistry / Q000235:genetics*; D016053:RNA, Protozoan / Q000235:genetics; D012352:RNA, Transfer, Glu / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA
D000953:Antigens, Protozoan; D008565:Membrane Proteins; D015800:Protozoan Proteins; D016053:RNA, Protozoan; D012352:RNA, Transfer, Glu; C057495:serine repeat antigen, Plasmodium