title: Optimization of contrast dosage for gadolinium-enhanced 3D MRA of the pulmonary and renal arteries.
abstract: To determine the minimal contrast dosage required for diagnostic contrast-enhanced three-dimensional (3D) magnetic resonance angiography (MRA) image quality of the pulmonary (PAs) or renal arteries (RAs). In 12 volunteers (10 females, 2 males; mean age 24 years) imaging was performed with 4 different dosages: 0.05, 0.1, 0.2 and 0.3 mmol/kg of body weight (BW) 0.5 M gadolinium (Gd) contrast agent. The PAs and RAs were evaluated separately each in groups of six volunteers. Qualitative and quantitative signal-to-noise ratio (SNR) image analysis was performed. For the PAs, the increases in signal-to-noise ratio were paralleled by increases in image quality ratings. For the PAs, with the use of 0.05 mmol/kg, only 50.3% of all segments were rated diagnostic, whereas with higher dosages the percentage rose to 89.2% for 0.1 mmol/kg, 98.2% for 0.2 mmol/kg. and 99.1% for 0.3 mmol/kg. For the RAs, 0.3 mmol/kg provided no significant increase in singal-to-noise ratio compared to 0.2 mmol/kg (p = 0.4). Only by a dosage of 0.2 and 0.3 mmol/kg, all evaluated segments were diagnostic evaluable. A dose of 0.2 mmol/kg is required for proper assessment of the RAs or PAs.
authors.affiliation: Department of Diagnostic Radiology, University Hospital Zurich, Zürich, Switzerland.
authors.forename: T F
authors.initials: TF
authors.lastname: Hany
authors.forename: M
authors.initials: M
authors.lastname: Schmidt
authors.forename: P R
authors.initials: PR
authors.lastname: Hilfiker
authors.forename: P
authors.initials: P
authors.lastname: Steiner
authors.forename: U
authors.initials: U
authors.lastname: Bachmann
authors.forename: J F
authors.initials: JF
authors.lastname: Debatin
mesh_terms: D000328:Adult; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D019786:Gadolinium DTPA / Q000008:administration & dosage; D006801:Humans; D007091:Image Processing, Computer-Assisted; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D011651:Pulmonary Artery / Q000033:anatomy & histology*; D012077:Renal Artery / Q000033:anatomy & histology*
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA