title: Interleukin-11 (IL-11) in aseptic loosening of total hip replacement (THR).
abstract: The chronic inflammatory response to abrasion particles from total hip replacement (THR) is believed to cause osteolysis and to contribute to prosthetic loosening. The expression of interleukin-11(IL-11) and its major cellular sources in the interface and pseudocapsular tissues obtained from total hip revisions performed for aseptic loosening were investigated. The avidin-biotin-peroxidase complex (ABC) and alkaline phosphatase-anti-alkaline phosphatase (APAAP) methods were used for staining and VIDAS image analysis for quantification. IL-11 was found in the interface and pseudocapsular tissues in the aseptic loosening of THR. IL-11 containing cells were more numerous in the interface (760 +/- 171 cells) and pseudocapsular tissues (684 +/- 171 cells) than in the control synovial tissue (235 +/- 68 cells). Because IL-11 is an important component of cytokine network mediating osteoblast-osteoclast communication in normal and pathological bone remodeling, the current findings suggest that IL-11 may contribute to periprosthetic osteolysis and to the loosening of THR.
authors.affiliation: Institute of Biomedicine, Department of Anatomy, University of Helsinki, Helsinki University Central Hospital, Finland.
authors.forename: J W
authors.initials: JW
authors.lastname: Xu
authors.forename: T F
authors.initials: TF
authors.lastname: Li
authors.forename: G
authors.initials: G
authors.lastname: Partsch
authors.forename: A
authors.initials: A
authors.lastname: Ceponis
authors.forename: S
authors.initials: S
authors.lastname: Santavirta
authors.forename: Y T
authors.initials: YT
authors.lastname: Konttinen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip; D001207:Asepsis; D005260:Female; D006622:Hip Prosthesis; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007124:Immunoenzyme Techniques; D017370:Interleukin-11 / Q000009:adverse effects / Q000378:metabolism*; D017746:Joint Capsule / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010014:Osteolysis / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D011475:Prosthesis Failure; D013583:Synovial Membrane / Q000378:metabolism* / Q000473:pathology
chemical_list: D017370:Interleukin-11