Safety and immunogenicity of HIV-1 DNA constructs in chimpanzees.
A global effort to control the HIV epidemic is likely to rely heavily on immunization strategies. As our closest genetic relative, the chimpanzee provides the most important model for preclinical safety and immunogenicity studies. We have immunized adult, pregnant and infant chimpanzees with our plasmid vaccines. We have found these vaccines to be safe and well tolerated in all of these groups. The same vaccines have induced both humoral and cellular immunity in each instance.
Bagarazzi
M L
ML
Allegheny University of the Health Sciences, Department of Pediatrics, St Christopher's Hospital for Children, Philadelphia, PA 19134, USA.
Boyer
J D
JD
Ugen
K E
KE
Javadian
M A
MA
Chattergoon
M
M
Shah
A
A
Bennett
M
M
Ciccarelli
R
R
Carrano
R
R
Coney
L
L
Weiner
D B
DB
D016915:AIDS Vaccines / Q000009:adverse effects / Q000276:immunology* / Q000627:therapeutic use; D000818:Animals; D004279:DNA, Viral / Q000235:genetics / Q000276:immunology*; D004195:Disease Models, Animal; D005260:Female; D015483:HIV Antibodies / Q000097:blood; D015658:HIV Infections / Q000097:blood / Q000517:prevention & control; D015497:HIV-1 / Q000235:genetics* / Q000276:immunology*; D016131:Lymphocyte Subsets / Q000276:immunology; D008297:Male; D002679:Pan troglodytes; D011247:Pregnancy; D019444:Vaccines, DNA / Q000009:adverse effects / Q000276:immunology* / Q000627:therapeutic use
D016915:AIDS Vaccines; D004279:DNA, Viral; D015483:HIV Antibodies; D019444:Vaccines, DNA