title: Post-spaceflight orthostatic intolerance: possible relationship to microgravity-induced plasticity in the vestibular system.
abstract: Even after short spaceflights, most astronauts experience at least some postflight reduction of orthostatic tolerance; this problem is severe in some subjects. The mechanisms leading to postflight orthostatic intolerance are not well-established, but have traditionally been thought to include the following: changes in leg hemodynamics, alterations in baroreceptor reflex gain, decreases in exercise tolerance and aerobic fitness, hypovolemia, and altered sensitivity of beta-adrenergic receptors in the periphery. Recent studies have demonstrated that signals from vestibular otolith organs play an important role in regulating blood pressure during changes in posture in a 1-g environment. Because spaceflight results in plastic changes in the vestibular otolith organs and in the processing of inputs from otolith receptors, it is possible that another contributing factor to postflight orthostatic hypotension is alterations in the gain of vestibular influences on cardiovascular control. Preliminary data support this hypothesis, although controlled studies will be required to determine the relationship between changes in the vestibular system and orthostatic hypotension following exposure to microgravity.
authors.affiliation: Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA 15213, USA. byates@pop.pitt.edu
authors.forename: B J
authors.initials: BJ
authors.lastname: Yates
authors.forename: I A
authors.initials: IA
authors.lastname: Kerman
mesh_terms: D006801:Humans; D018472:Hypogravity; D009473:Neuronal Plasticity / Q000502:physiology*; D011187:Posture / Q000502:physiology*; D013026:Space Flight; D014722:Vestibule, Labyrinth / Q000502:physiology*