title: Imipenem inhibits in vitro activity of amphotericin B directed against Aspergillus fumigatus.
abstract: A decrease of the susceptibility of Aspergillus fumigatus strains to amphotericin B was found when tested in combination with high concentrations (128-2048 mg/l) of the antibacterial agent imipenem by checkerboard titration and agar diffusion assay. Only bacteriologically active imipenem showed the antagonism. The mechanism of action is unknown. However, imipenem and amphotericin B did not react directly, as shown by checkerboard titration with bacterial strains as well as by HPLC analysis. It is concluded that imipenem medication may influence the efficacy of amphotericin B treatment in aspergillosis.
authors.affiliation: Institut für Medizinische Mikrobiologie, Universität-GH Essen, Germany.
authors.forename: P M
authors.initials: PM
authors.lastname: Rath
authors.forename: J W
authors.initials: JW
authors.lastname: Hülsewede
authors.forename: R
authors.initials: R
authors.lastname: Ansorg
mesh_terms: D000666:Amphotericin B / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000935:Antifungal Agents / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D001232:Aspergillus fumigatus / Q000187:drug effects*; D004336:Drug Antagonism; D015378:Imipenem / Q000494:pharmacology*; D013845:Thienamycins / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D013845:Thienamycins; D015378:Imipenem; D000666:Amphotericin B