title: Clinical, radiological and histological presentations of dysembryoplastic neuroepithelial tumors (DNT). Report of two cases.
abstract: Dysembryoplastic neuroepithelial tumor (DNT) is a recently described rare brain neoplasm with characteristic clinical and morphological features and favorable prognosis. We report here two cases of DNT. The first concerned a 12 years old girl who presented complex seizures preceded by acoustic aura (melodies). Computed tomography revealed a hypodense tumor measuring 2 x 2.5 cm in diameter, located paracortically in the left temporal lobe. The second tumor was removed from a 21-year-old man with partial complex seizures. Nine years earlier patient underwent neurosurgery with partial removal of the tumor The tumor's histopathologic diagnosis is unfortunately lacking. Computed and magnetic resonance imaging showed a mass occupying the cortex and paracortical areas of the anterior pole of the temporal lobe. Histologically, both tumors consisted of small, S-100 protein immunopositive oligodendrocyte-like cells (OLCs) arranged between synaptophysin- and, to a lesser degree, NFP-immunopositive axons (glioneuronal element). In the second case, an area of pilocytic astrocytoma-like appearance was also found, these cells were immunopositive for GFAP. The present study provides clinical, radiological and histological data, which may be helpful in differential diagnosis of this newly recognised brain tumor.
authors.affiliation: Laboratories of Tumor Biology, School of Medicine, Lódź, Poland.
authors.forename: R
authors.initials: R
authors.lastname: Kordek
authors.forename: J
authors.initials: J
authors.lastname: Waschnitz
authors.forename: W
authors.initials: W
authors.lastname: Biernat
authors.forename: W
authors.initials: W
authors.lastname: Saringer
authors.forename: T
authors.initials: T
authors.lastname: Czech
authors.forename: K
authors.initials: K
authors.lastname: Zakrzewski
authors.forename: L
authors.initials: L
authors.lastname: Polis
authors.forename: J
authors.initials: J
authors.lastname: Alwasiak
authors.forename: P P
authors.initials: PP
authors.lastname: Liberski
authors.forename: H
authors.initials: H
authors.lastname: Budka
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000196:embryology / Q000473:pathology* / Q000601:surgery; D002648:Child; D005260:Female; D005904:Glial Fibrillary Acidic Protein; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D018302:Neoplasms, Neuroepithelial / Q000000981:diagnostic imaging* / Q000196:embryology / Q000473:pathology* / Q000601:surgery; D011859:Radiography; D012640:Seizures / Q000175:diagnosis
chemical_list: D005904:Glial Fibrillary Acidic Protein