Effect of intensive magnesium supplementation on the in vitro oxidizability of LDL and VLDL in Mg-depleted type 1 diabetic patients.
Type 1 diabetic patients with low RBC-MG have an increased in vitro oxidizability of LDL and VLDL as compared to matched diabetic controls with normal RBC-MG. In this study the effect of a 10 week intensive oral + i.v. supplementation with Mg was studied in 11 depleted type 1 patients under stable metabolic control. Despite the significant increase of erythrocyte Mg and the higher body stores demonstrated by the Mg retention test, no significant decrease of the oxidizability could be demonstrated after supplementation. Persistent Mg loss in the presence of peripheral hyperinsulinaemia, insufficient and/or too short supplementation and decreased antioxidant defence could be the reasons for this negative result.
De Leeuw
I
I
Department of Endocrinology, University of Antwerp, Belgium.
Engelen
W
W
Aerts
P
P
Schrans
S
S
D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy* / Q000378:metabolism*; D019587:Dietary Supplements; D006801:Humans; D008077:Lipoproteins, LDL / Q000187:drug effects / Q000378:metabolism*; D008079:Lipoproteins, VLDL / Q000187:drug effects / Q000378:metabolism*; D008274:Magnesium / Q000097:blood / Q000494:pharmacology*; D010084:Oxidation-Reduction; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis
D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D017392:Thiobarbituric Acid Reactive Substances; D008274:Magnesium