Noninsulin-dependent diabetes mellitus as a mitochondrial genomic disease.
The genetics of diabetes mellitus is very complex. Although the phenotypes are relatively simple vis-a-vis an abnormal glucose-insulin relationship, a number of genotypes share this phenotype. This review focuses on mutations in the mitochondrial genome that phenotype as diabetes mellitus. Studies in the human and the rat are described.
Mathews
C E
CE
Department of Foods and Nutrition, The University of Georgia, Athens 30602-3622, USA.
Berdanier
C D
CD
D000818:Animals; D004272:DNA, Mitochondrial / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000473:pathology; D015894:Genome, Human; D006801:Humans; D008928:Mitochondria / Q000235:genetics; D009154:Mutation; D051381:Rats
D004272:DNA, Mitochondrial