title: Persistent cognitive and motor deficits following acute hydrogen sulphide poisoning.
abstract: This case study describes the long-term after-effects of hydrogen sulphide exposure in a previously health 27-year-old male. Upon hospital admission the patient had a Glasgow Coma Score (CGS) of 3; with emergency treatment including hyperbaric oxygen treatments, he progressed to a GCS of 15 on day 7. Although both CT and MRI scans were unremarkable, PET using F-18 deoxyglucose administered 3 years after the accident showed abnormally decreased metabolism bilaterally in the temporal and inferior parietal lobes as well as the left thalamus. Uptake in the striatum was heterogeneous and abnormal. A cerebral perfusion study using SPECT performed 3.5 years after the accident revealed bilaterally decreased flow in the putamen but no cortical abnormalities. Neuropsychological and neurofunctional testing revealed the following impairments: microsmia, psychomotor slowing, extrapyramidal signs and deficits in memory and executive/planning functioning. These findings are discussed in the context of hydrogen sulphide's known mechanisms of toxicity and the functions of the basal ganglia.
authors.affiliation: Thomas Jefferson University Medical School, Department of Pathology, Philadelphia, PA 19107, USA.
authors.forename: J S
authors.initials: JS
authors.lastname: Schneider
authors.forename: E H
authors.initials: EH
authors.lastname: Tobe
authors.forename: P D
authors.initials: PD
authors.lastname: Mozley
authors.forename: L
authors.initials: L
authors.lastname: Barniskis
authors.forename: T I
authors.initials: TI
authors.lastname: Lidsky
mesh_terms: D000328:Adult; D003072:Cognition Disorders / Q000139:chemically induced*; D006801:Humans; D006862:Hydrogen Sulfide / Q000506:poisoning*; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D016273:Occupational Exposure / Q000009:adverse effects*; D011596:Psychomotor Disorders / Q000139:chemically induced*; D012498:Sanitary Engineering; D012722:Sewage; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D012722:Sewage; D006862:Hydrogen Sulfide