A dose response study of hepatitis A vaccine in healthy adults who are > or = 30 years old and weigh > or = 77 kg.
The dose response relationship of 25-, 50-, and 100-U doses of an inactivated hepatitis A vaccine was examined in 358-seronegative volunteers in a 2-dose schedule. The 50-U and 100-U groups had statistically significantly higher seroconversion rates than the 25-U group at weeks 2, 4, 8, and 24. Seroconversion was statistically significantly greater for the 100-U compared with the 25- and 50-U doses 2 weeks after the first injection but was not significantly different by 4 weeks after the first injection in the 50- and 100-U dose groups. After 2 injections, all subjects in all groups seroconverted. The vaccine was well tolerated at all dosage levels.
Bertino
J S
JS
Department of Pharmacy Services, Bassett Healthcare, Cooperstown, New York 13326-1394, USA. jbertino@usa.net
Thoelen
S
S
VanDamme
P
P
Bryan
J P
JP
Becherer
P R
PR
Frey
S
S
Hayden
F G
FG
Marcus
L C
LC
Parenti
D M
DM
Sperling
M
M
Chan
I S
IS
Brown
L
L
Nalin
D
D
D000328:Adult; D000368:Aged; D001835:Body Weight; D004305:Dose-Response Relationship, Drug; D005260:Female; D006508:Hepatitis Antibodies / Q000097:blood*; D006507:Hepatovirus / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology; D014761:Viral Hepatitis Vaccines / Q000008:administration & dosage* / Q000276:immunology*
D006508:Hepatitis Antibodies; D015164:Vaccines, Inactivated; D014761:Viral Hepatitis Vaccines