Immunohistochemical localization of the angiotensin II type 1 receptor in human hypothalamus and brainstem.
We studied the distribution of the angiotensin II type 1 (AT-1) receptor using a polyclonal rabbit antibody in two human brains. AT-1 receptor immunoreactivity was detected in several hypothalamic nuclei, substantia nigra, locus coeruleus, nucleus tractus solitarius, ventrolateral medulla, pontine nuclei, and inferior olivary nucleus. This provides direct evidence of neuronal localization of the AT-1 receptor in autonomic and motor areas in human brain.
Benarroch
E E
EE
Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. benarroch.eduardo@mayo.edu
Schmeichel
A M
AM
D000368:Aged; D000369:Aged, 80 and over; D001933:Brain Stem / Q000737:chemistry*; D006801:Humans; D007031:Hypothalamus / Q000737:chemistry*; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D044140:Receptor, Angiotensin, Type 1; D044139:Receptor, Angiotensin, Type 2; D011945:Receptors, Angiotensin / Q000032:analysis*
D044140:Receptor, Angiotensin, Type 1; D044139:Receptor, Angiotensin, Type 2; D011945:Receptors, Angiotensin