Elevated plasma levels of homocysteine in Parkinson's disease.
Significantly elevated plasma levels of homocysteine, but not cysteine and cysteinylglycine, were found in treated parkinsonian patients compared to controls. Elevated levels of homocysteine may be either caused by an unknown endogenous metabolic disturbance or by antiparkinsonian treatment, because no association to severity or duration of disease was found. Based on the results of this study one may speculate that homocysteine may be an independent risk factor for vascular disease in Parkinson's disease.
Kuhn
W
W
Department of Neurology, St. Josef Hospital, Ruhr University Bochum, Germany.
Roebroek
R
R
Blom
H
H
van Oppenraaij
D
D
Przuntek
H
H
Kretschmer
A
A
Büttner
T
T
Woitalla
D
D
Müller
T
T
D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003545:Cysteine / Q000097:blood; D004151:Dipeptides / Q000097:blood; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood*; D012307:Risk Factors
D004151:Dipeptides; D006710:Homocysteine; C028505:cysteinylglycine; D003545:Cysteine