title: Preselected biopsy for normal-appearing mucosa of superficial bladder carcinoma.
abstract: OBJECTIVE
  We examined the incidence of positive findings (concomitant carcinoma in situ (CIS), frank carcinoma and dysplasia) for normal-appearing mucosal biopsies in superficial bladder carcinoma and the clinical outcome of patients with positive biopsy results.
  
  
  METHODS
  Eighty-four cases of newly diagnosed superficial bladder carcinoma, from whom biopsies of preselected cystoscopically normal-appearing mucosal tissue were taken at the time of initial treatment, were studied. Multivariate analysis by Cox's proportional hazards model was applied.
  
  
  RESULTS
  Twenty-seven percent of the patients with superficial bladder carcinoma showed positive biopsy results. Positive biopsy results independently influenced intravesical recurrence by Cox's proportional hazards model.
  
  
  CONCLUSIONS
  Positive mucosal biopsy results are a significant indicator of intravesical recurrence in patients with superficial bladder carcinoma.
authors.affiliation: Departments of Urology and Clinical Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Miyao
authors.forename: T
authors.initials: T
authors.lastname: Hisataki
authors.forename: A
authors.initials: A
authors.lastname: Takahashi
authors.forename: N
authors.initials: N
authors.lastname: Masumori
authors.forename: M
authors.initials: M
authors.lastname: Satoh
authors.forename: T
authors.initials: T
authors.lastname: Tsukamoto
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001707:Biopsy, Needle; D002277:Carcinoma / Q000473:pathology* / Q000628:therapy; D002295:Carcinoma, Transitional Cell / Q000473:pathology* / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D015653:Cystectomy; D003558:Cystoscopy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology; D015999:Multivariate Analysis; D016016:Proportional Hazards Models; D012680:Sensitivity and Specificity; D001749:Urinary Bladder Neoplasms / Q000473:pathology* / Q000628:therapy