Non-nociceptive capsaicin-sensitive nerve terminal stimulation allows for an original vasodilatory reflex in the human skin.
A significant increase of cutaneous laser Doppler flowmetry was found before blood flow decreases with increasing pressure during a 5 mmHg min-1 increase of pressure strain on the finger. Pre-treatment with a local anaesthetic or chronically applied capsaicin, resulted in the disappearance of the vasodilatory response. These results suggest an original vasodilatory axon reflex response to non-noxious pressure strain which is initiated by capsaicin-sensitive nerve terminals in the human skin.
Fromy
B
B
Laboratoire de Physiologie et d'Explorations Vasculaires, Centre Hospitalier Universitaire d' Angers, 49033, Angers Cedex 01, France.
Abraham
P
P
Saumet
J L
JL
D002211:Capsaicin / Q000494:pharmacology*; D006801:Humans; D006940:Hyperemia / Q000139:chemically induced; D009411:Nerve Endings / Q000187:drug effects*; D009412:Nerve Fibers / Q000187:drug effects; D012016:Reference Values; D012018:Reflex / Q000502:physiology*; D012867:Skin / Q000098:blood supply / Q000294:innervation*; D013268:Stimulation, Chemical; D014664:Vasodilation / Q000502:physiology*
D002211:Capsaicin