Phytochemical and pharmacological analysis of different parts of Wedelia paludosa DC. (Compositae).
This study demonstrates the chromatographic profile and antinociceptive action of methanolic extracts obtained from different parts of Wedelia paludosa, a medicinal plant employed in folk medicine to treat dolorous processes. The results indicated that the root was the most potent part whereas the flower exhibited a weak antinociceptive activity. Comparative TLC suggested that all extract show different constituents or concentrations. Kaurenoic acid and stigmasterol were detected in all extracts and luteolin is present only in leaves and stems, but in small quantities. These results confirm our previous investigation on this plant and support its popular use for the treatment of algesic processes.
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Químico-Farmacêuticas (NIQFAR)/CCS, Universidade do Vale do Itajaí (UNIVALI), Itajaí, SC, Brazil.
Scheidt
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C
Quintão
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NL
Santos
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AR
Cechinel-Filho
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V
D019342:Acetic Acid / Q000037:antagonists & inhibitors; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D002855:Chromatography, Thin Layer; D008297:Male; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects; D018515:Plant Leaves / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
D018712:Analgesics, Non-Narcotic; D019342:Acetic Acid