title: [Effectiveness of intensive preoperative radiotherapy of locally- advanced breast tumors].
abstract: The investigation was concerned with the effectiveness of intensive preoperative radiotherapy (IPRT) in 423 patients with locally-advanced breast tumors (pT1-2N0M0) after radical surgery. No significant effect on overall or recurrence-free survival (pT1N0M0) was observed following IPRT as a component of combination and complex therapy. Overall and recurrence-free survival (pT2N0M0) was higher (p < 0.05) after IPRT in patients who did not receive chemo- or hormonal therapy. The results did not change significantly in the hT2N0M0 group when IPRT was combined with postoperative chemo- and hormonal therapy.
authors.affiliation: Prof. N.N. Petrov Research Institute of Oncology, Health Ministry of the RF, St. Petersburg.
authors.forename: S V
authors.initials: SV
authors.lastname: Kanaev
authors.forename: V F
authors.initials: VF
authors.lastname: Semiglazov
authors.forename: E I
authors.initials: EI
authors.lastname: Tiuriaeva
authors.forename: A A
authors.initials: AA
authors.lastname: Sokolov
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant; D016019:Survival Analysis; D016896:Treatment Outcome