Disulfiram effects on acute cocaine administration.
Disulfiram (Antabuse) is being used in outpatient clinical trials to determine its efficacy as a treatment for cocaine dependence. This inpatient randomized, double-blind, placebo-controlled, within-subjects study was conducted to determine whether disulfiram (placebo, 250 or 500 mg/day) alters responses to acute intranasal cocaine (placebo, 1 or 2 mg/kg) administration. Effects of disulfiram on cocaine pharmacokinetics, physiological, and behavioral responses were determined. Disulfiram treatment increased plasma cocaine concentrations three to six times and significantly increased cocaine-associated cardiovascular responses, but did not significantly alter behavioral responses to cocaine. These interactions should be considered in the decision regarding disulfiram treatment in cocaine dependent patients.
McCance-Katz
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EF
Yale Psychiatric Institute, New Haven, CT, USA.
Kosten
T R
TR
Jatlow
P
P
D000208:Acute Disease; D000328:Adult; D000427:Alcohol Deterrents / Q000494:pharmacology / Q000627:therapeutic use*; D002802:Cholinesterases / Q000097:blood / Q000378:metabolism; D019970:Cocaine-Related Disorders / Q000188:drug therapy*; D004221:Disulfiram / Q000494:pharmacology / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D013997:Time Factors
D000427:Alcohol Deterrents; D002802:Cholinesterases; D004221:Disulfiram