title: Drug-induced thrombocytopenia presenting with isolated oral lesions: report of two cases.
abstract: Patients with platelet-mediated bleeding disorders often present with clinical manifestations of bruising and bleeding. Although these changes are detected most frequently on the skin and in the oral cavity, the nasal and genital mucosa, as well as the renal and gastrointestinal systems, also may exhibit signs of bleeding. In this report, we describe two patients who presented with isolated oral features: one with oral hemorrhagic bullae and a second with oral petechiae and gingival bleeding indicative of a bleeding disorder. Results of laboratory tests revealed severe thrombocytopenia and a careful history disclosed drug hypersensitivity as the cause. It is important to recognize the oral manifestations of thrombocytopenia since the oral cavity is a frequent site of hemorrhage and may be the only manifestation of the disease. Proper identification permits the prompt institution of treatment and prevention of serious complications.
authors.affiliation: Dermatology Research Associates, Cincinnati, Ohio 45230, USA.
authors.forename: D
authors.initials: D
authors.lastname: Eisen
authors.forename: J
authors.initials: J
authors.lastname: Essell
mesh_terms: D001768:Blister / Q000139:chemically induced; D003937:Diagnosis, Differential; D004342:Drug Hypersensitivity / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000139:chemically induced*; D006472:Oral Hemorrhage / Q000139:chemically induced; D011696:Purpura, Thrombocytopenic / Q000139:chemically induced; D013921:Thrombocytopenia / Q000139:chemically induced*