[Effect of plaunotol on trinitrobenzene sulfonic acid and acetic acid induced colonic lesions in rats].
The aim of this study was to assess the effect of plaunotol, an anti-ulcer agent, on trinitrobenzene sulfonic acid (TNB)- and acetic acid-induced colonic lesions in rats. Plaunotol significantly reduced the severity of colonic mucosal lesions induced by TNB at a dose of 600 mg/kg/day. Moreover, plaunotol, at a dose of 600 mg/kg/day, significantly depressed the myeloperoxidase activity of the lesioned area induced by TNB of the rat colon. In the model of colitis induced by acetic acid, plaunotol reduced the area of lesions dose-dependently and significantly at doses of 60, 200 and 600 mg/kg/day as assessed by macroscopic observation. Microscopic observation showed obvious changes by administration of plaunotol such as reduction of epithelial cell necrosis, decreased mucin production and a decreased infiltration of a large number of neutrophils. In conclusion, plaunotol showed a protective effect against colonic lesion formation induced by TNB and acetic acid in rats. This study suggests the possibility that plaunotol may be effective and useful for treatment of inflammatory bowel disease in humans.
Makino
M
M
Pharmacology & Molecular Biology Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
Inomata
Y
Y
Ito
K
K
Tabata
K
K
D019342:Acetic Acid; D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D003106:Colon / Q000473:pathology; D004195:Disease Models, Animal; D004224:Diterpenes; D004305:Dose-Response Relationship, Drug; D005233:Fatty Alcohols / Q000627:therapeutic use*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014302:Trinitrobenzenesulfonic Acid
D000897:Anti-Ulcer Agents; D004224:Diterpenes; D005233:Fatty Alcohols; D014302:Trinitrobenzenesulfonic Acid; C047686:plaunotol; D019342:Acetic Acid