[Study on therapeutic effect and immunological mechanism of fuzhengfang herbs in mice with Lewis lung cancer].
OBJECTIVE
To observe the therapeutical effect of Fuzhengfang (FZF).


METHODS
Therapeutic effect of FZF herbs on mice with Lewis lung cancer was observed, and its regulation on function of red blood cell immune system of the mice was also studied.


RESULTS
FZF herbs could inhibit the growth of tumor, and increase the weight of mice with Lewis lung cancer. The quality of life of the mice was improved after treatment with FZF herbs. FZF herbs could increase the activity of red blood cell C3b receptors, reduce the quantity of red blood cell immune complexes, elevate the immune adherent function of red blood cells to tumor cells, raise activity of red blood cell immune adherent enhancing factors in serum, and lower the activity of red blood cell immune adherent inhibitory factors. Chemotherapy could inhibit the growth of tumor, but decrease the weight of mice with Lewis lung cancer. The quality of life of the mice was decreased after chemotherapy. Chemotherapy could reduce the activity of red blood cell C3b receptors, increase the quantity of red blood cell immune complexes, depress the immune adherent function of red blood cells to tumor cells, lower the activity of red blood cell immune adherent enhancing factors in serum, and raise the activity of red blood cell immune adherent inhibitory factors in serum. There was a significant difference between FZF herbs and chemotherapy.


CONCLUSIONS
FZF herbs have a positive therapeutic effect in mice with Lewis lung cancer, and its mechanism might be associated with improving function of red blood cell immune system of mice with Lewis lung cancer.
Cheng
X D
XD
State Key Laboratory of Medical Neurobiology of Shanghai Medical University.
Guo
F
F
Liu
J X
JX
D000818:Animals; D000936:Antigen-Antibody Complex / Q000378:metabolism; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy / Q000276:immunology*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004912:Erythrocytes / Q000276:immunology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011897:Random Allocation; D017463:Receptors, Complement 3b / Q000378:metabolism*; D012397:Rosette Formation
D000936:Antigen-Antibody Complex; D004365:Drugs, Chinese Herbal; D017463:Receptors, Complement 3b