title: Brain choline has a typical precursor profile.
abstract: Choline is product and precursor to both acetylcholine and membrane phospholipids, and, in the brain, is ultimately provided by the circulation. The brain is protected from excess choline and choline deprivation by a refined system of homeostatic mechanisms that maintain a level of extracellular choline that, for its role as precursor, meets saturation criteria under normal conditions. The kinetic and activity profiles of choline are typical for a biosynthetic precursor.
authors.affiliation: Department of Pharmacology, University of Mainz, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Löffelholz
mesh_terms: D000109:Acetylcholine / Q000096:biosynthesis*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002794:Choline / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D007700:Kinetics; D010743:Phospholipids / Q000096:biosynthesis*; D013569:Synapses / Q000378:metabolism
chemical_list: D010743:Phospholipids; D002794:Choline; D000109:Acetylcholine