Signal transduction pathways and modulation of gene activity.
Research over the last decade has provided us with much information about the mechanisms that integrate signal transduction pathways with specific gene expression programs. We discuss the types of mechanisms used by different pathways to modulate transcription factor activity, citing examples from diverse molecular systems. Careful regulation of these pathways is essential to maintain balanced transcriptional control. Understanding the mechanisms that control gene activity will enable us to intervene therapeutically in diseases associated with deregulated transcriptional activity.
Weitzman
J B
JB
Unité des Virus Oncogènes, URA 1644 du CNRS, Institut Pasteur, Paris, France.
Yaniv
M
M
D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D007372:Interferons / Q000378:metabolism; D007378:Interleukins / Q000378:metabolism; D016328:NF-kappa B; D010766:Phosphorylation; D016160:Retinoblastoma Protein / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism
D007378:Interleukins; D016328:NF-kappa B; D016160:Retinoblastoma Protein; D014157:Transcription Factors; D007372:Interferons; D017868:Cyclic AMP-Dependent Protein Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases