Independent isolates of the emerging subgroup J avian leukosis virus derive from a common ancestor.
A new subgroup of avian leukosis virus (ALV) that includes a unique env gene, designated J, was identified recently in England. Sequence analysis of prototype English isolate HPRS-103 revealed several other unique genetic characteristics of this strain and provided information that it arose by recombination between exogenous and endogenous virus sequences. In the past several years, ALV J type viruses (ALV-J) have been isolated from broiler breeder flocks in the United States. We were interested in determining the relationship between the U.S. and English isolates of ALV-J. Based on sequence data from two independently derived U.S. field isolates, we conclude that the U.S. and English isolates of ALV-J derive from a common ancestor and are not the result of independent recombination events.
Benson
S J
SJ
Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA.
Ruis
B L
BL
Garbers
A L
AL
Fadly
A M
AM
Conklin
K F
KF
D000595:Amino Acid Sequence; D000818:Animals; D001353:Avian Leukosis / Q000821:virology; D001354:Avian Leukosis Virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D001483:Base Sequence; D002645:Chickens; D004279:DNA, Viral / Q000235:genetics; D004739:England; D019143:Evolution, Molecular; D020440:Gene Duplication; D015752:Genes, env; D015751:Genes, pol; D008969:Molecular Sequence Data; D011995:Recombination, Genetic; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D014481:United States
D004279:DNA, Viral