title: Bifurcations in the decremental propagation of a spike train in the Hodgkin-Huxley model of low excitability.
abstract: Response of a nerve fiber of low excitability to periodic stimulus pulses is studied with computer simulation of the Hodgkin-Huxley model. The excitability of the Hodgkin-Huxley model is reduced by decreasing the equilibrium potential for the sodium ion and by increasing the temperature, so that the decremental propagation of spikes occurs in the refractory period. It is shown that, as the period of stimulus pulses is decreased, the propagation length of the spikes is continuously changed, and period-doubling bifurcations occur. The response of a nerve fiber of low excitability is then qualitatively different from that of a normal fiber.
authors.affiliation: Faculty of Engineering, Kagawa University, Takamatsu, Japan. horikawa@eng.kagawa-u.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Horikawa
mesh_terms: D000818:Animals; D003198:Computer Simulation; D003491:Cybernetics; D004558:Electric Stimulation; D004594:Electrophysiology; D008564:Membrane Potentials; D008959:Models, Neurological; D009412:Nerve Fibers / Q000502:physiology*; D009431:Neural Conduction / Q000502:physiology; D012964:Sodium / Q000378:metabolism; D013696:Temperature
chemical_list: D012964:Sodium