Immunotherapy for scorpion envenoming in Brazil.
Using the ELISA we have shown that in rats subcutaneously injected with Tityus serrulatus scorpion venom there is a fast absorption rate, a fast and high distribution of venom to tissues, a great affinity of the venom for the tissues and a slow elimination half-life. Because of these experimental data, i.v. immunotherapy should be given to patients stung by scorpions as soon as possible after hospital admission. The severity of scorpion envenoming is related to plasma venom concentration (ELISA). The high levels of plasma scorpion venom antigens (ELISA) were cleared 1 h after the infusion of antivenom (5-30 ml of Fab2 fragment) and high concentrations of circulating antivenom persisted for at least 24 h, confirming the efficacy of immunotherapy to neutralise circulating venom. Some symptoms (e.g. local pain and vomiting) decreased 1 h after the starting of immunotherapy, whereas the other symptoms disappeared from 12-48 h later. Using our tripartite approach of treating scorpion envenoming (symptomatic measures, support of vital functions and serotherapy), the mortality rate was very low (0.28%).
Rezende
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Departamento de Clínica Médica, Faculdade de Medicina, UFMG, Belo Horizonte, Brazil.
Amaral
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CF
Freire-Maia
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L
D000818:Animals; D001938:Brazil; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000627:therapeutic use; D007167:Immunotherapy; D051381:Rats; D065008:Scorpion Stings / Q000276:immunology / Q000378:metabolism / Q000401:mortality / Q000628:therapy*; D012604:Scorpion Venoms / Q000276:immunology* / Q000493:pharmacokinetics; D012605:Scorpions
D007140:Immunoglobulin Fab Fragments; D012604:Scorpion Venoms