Differential effects of organometallic tin compounds on Na+/K+-ATPase activity.
In vitro effects of six dibenzyltin dichloride (A-series) and another six dibenzyltin diisothiocyanate (B-series) complexes on Na+/K+-ATPase were studied. The rat brain synaptic membranes were prepared and significant ATPase inhibition was observed with all the complexes in a dose-dependent manner. The order of potency on Na+/K+-ATPase activity of the chloride complexes was found to be higher than that of the isothiocyanate complexes. The IC50 values range from 64 microM to 252 microM for the chloride complexes and from 132 microM to 399 microM for the isothiocyanate complexes. A structure-activity relationship could be derived for the chloride complexes.
Samuel
P M
PM
Metallo-Organic Laboratory, I&PC Division, Indian Institute of Chemical Technology, Hyderabad.
Roy
S
S
Jaiswal
K A
KA
Rao
J V
JV
D000818:Animals; D001593:Benzyl Compounds / Q000494:pharmacology; D001921:Brain / Q000201:enzymology*; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D008297:Male; D009947:Organotin Compounds / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013570:Synaptic Membranes / Q000201:enzymology
D001593:Benzyl Compounds; D009947:Organotin Compounds; C070406:dibenzyltin dichloride; D000254:Sodium-Potassium-Exchanging ATPase