In vitro release of cytarabine from swellable matrices of CnEmCn triblock copolymers.
Matrices loaded with cytarabine were prepared by compression of the tailor made triblock copolymers C17E227C17 and C17E454C17 (where C=methylene and E=oxyethylene). Observations of the swelling characteristics of copolymer matrices on immersion in distilled water indicated an increase in the thickness of the gel layer around the matrices following ingress of water into the matrices. The in vitro release of cytarabine was characterised from matrices of different molar mass and with different known drug loadings. The release of cytarabine from the copolymer matrices was predominantly by a Fickian diffusion mechanism; the release rate was dependent on drug loading and independent of copolymer molar mass.
Ameri
M
M
Manchester Polymer Centre, School of Pharmacy and Pharmaceutical Sciences and Department of Chemistry, University of Manchester, Manchester M13 9PL, UK.
Collett
J H
JH
Attwood
D
D
Booth
C
C
D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry*; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D003561:Cytarabine / Q000008:administration & dosage / Q000737:chemistry*; D003692:Delayed-Action Preparations; D006838:Hydrocarbons; D007700:Kinetics; D008697:Methane / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry; D010592:Pharmaceutic Aids / Q000008:administration & dosage / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000737:chemistry*
D000964:Antimetabolites, Antineoplastic; D003692:Delayed-Action Preparations; D006838:Hydrocarbons; D010592:Pharmaceutic Aids; D003561:Cytarabine; C030011:carbene; D011092:Polyethylene Glycols; D008697:Methane