title: [Gene sequence analysis of suppressor oncogene p53 in bladder carcinoma].
abstract: A prospective study which analyzes the presence of mutations in the suppressor oncogene p53 through automated genome sequentiation in 75 specimens of transitional cell carcinoma. The presence of mutations correlated to the pathological stage and cellular grade. Also, both the different types of mutations detected and the diversity of their location indicate the heterogeneity of bladder transitional cells carcinoma. The automated genome sequentiation method allows to detect both the type of mutation and the exact location. The detection of suppressor oncogene p53 mutations allows to identify those patients who may be at higher risk of disease progression and therefore those who should undergo a more intense follow-up.
authors.affiliation: Departamento de Urología, Clínica Universitaria de Navarra.
authors.forename: D
authors.initials: D
authors.lastname: Rosell Costa
authors.forename: J
authors.initials: J
authors.lastname: García-Foncillas Lopez
authors.forename: J I
authors.initials: JI
authors.lastname: Díez-Caballero Vivas-Pérez
authors.forename: J A
authors.initials: JA
authors.lastname: Garcia-Tapia
authors.forename: G
authors.initials: G
authors.lastname: Sanz Pérez
authors.forename: F D
authors.initials: FD
authors.lastname: Abad Alonso
authors.forename: A
authors.initials: A
authors.lastname: Martín-Marquina Aspiunza
authors.forename: F I
authors.initials: FI
authors.lastname: Rodríguez-Rubio Cortadellas
authors.forename: J E
authors.initials: JE
authors.lastname: Robles García
authors.forename: J J
authors.initials: JJ
authors.lastname: Zudaire Bergera
authors.forename: J M
authors.initials: JM
authors.lastname: Berián Polo
mesh_terms: D002295:Carcinoma, Transitional Cell / Q000235:genetics / Q000473:pathology; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D011446:Prospective Studies; D017422:Sequence Analysis, DNA; D001749:Urinary Bladder Neoplasms / Q000235:genetics* / Q000473:pathology