title: Changes in the secretory activity of the subcommissural organ of spontaneously hypertensive rats.
abstract: The subcommissural organ (SCO) is a glandular circumventricular organ secreting glycoproteins into the cerebrospinal fluid. The SCO of 15-week-old spontaneously hypertensive rats (SHR) and of matched normotensive Wistar-Kyoto rats (WKY) was studied immunocytochemically by using an antibody against the glycoproteins secreted by the SCO. The blood pressure, water intake and volume of brain ventricles of SHR and WKY rats were also recorded. The SHR were hypertensive, drank more water and did not display dilatation of the brain ventricles. The SCO of the SHR rats showed a drastic decrease of the immunoreactive material stored in the rough endoplasmic reticulum whereas the amount of immunoreactive apical secretory granules did not vary with respect to the SCO of WKY rats. These changes are compatible with an increased secretory activity of the SCO of the SHR rats. It is suggested that the changes in the SCO of SHR rats, and their hypertensive state, are interrelated phenomena.
authors.affiliation: Departamento de Anatomía Humana, Facultad de Medicina, Universidad de La Laguna, Tenerife, Spain. acastane@ull.es
authors.forename: A
authors.initials: A
authors.lastname: Castañeyra-Perdomo
authors.forename: E
authors.initials: E
authors.lastname: Carmona-Calero
authors.forename: G
authors.initials: G
authors.lastname: Meyer
authors.forename: H
authors.initials: H
authors.lastname: Pérez-González
authors.forename: M M
authors.initials: MM
authors.lastname: Pérez-Delgado
authors.forename: N
authors.initials: N
authors.lastname: Marrero-Gordillo
authors.forename: S
authors.initials: S
authors.lastname: Rodríguez
authors.forename: E M
authors.initials: EM
authors.lastname: Rodríguez
mesh_terms: D000818:Animals; D000906:Antibodies / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D004326:Drinking / Q000502:physiology; D006023:Glycoproteins / Q000276:immunology; D006973:Hypertension / Q000209:etiology; D007150:Immunohistochemistry; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012965:Sodium Chloride / Q000378:metabolism; D013351:Subcommissural Organ / Q000166:cytology / Q000378:metabolism* / Q000502:physiology*; D014882:Water-Electrolyte Balance / Q000502:physiology
chemical_list: D000906:Antibodies; D006023:Glycoproteins; D012965:Sodium Chloride