title: Pathologic features of initial adenomas as predictors for metachronous adenomas of the rectum.
abstract: BACKGROUND
  Colorectal cancer is the third most common cancer in the world, arising mostly from pre-existing adenomatous polyps (adenomas) of the large bowel. Patients with colorectal adenomas are at increased risk of colorectal cancer because of a high recurrence rate for adenomas. We followed a cohort of 1490 patients with rectal adenomas to determine whether recurrence might be related to pathologic characteristics of the initial adenomas.
  
  
  METHODS
  The patients were identified in Haining County, China, from 1977 through 1978 by means of examination with a 15-cm rigid sigmoidoscope. They were followed by endoscopic examination at years 2, 4, 6, 11, and 16 after their initial polypectomy. New adenomas in the rectum were identified in 280 patients in these follow-up examinations.
  
  
  RESULTS
  Statistically significant twofold to threefold elevated risks of metachronous (recurrent) adenomas were observed for patients who had more than two initial adenomas or whose most advanced initial adenoma was more than 1.0 cm in size, was of villous/tubulovillous type, or showed moderate to severe dysplasia. Much stronger associations were observed for advanced metachronous neoplasms, which are defined as cancers or adenomas with severe dysplasia, with multivariate adjusted relative risks (95% confidence interval) of 4.2 (1.8-9.9) for a large initial adenoma (>1.0 cm), 8.1 (4.2-15.6) for villous/tubulovillous architecture, and 14.4 (5.0-41.3) for severe dysplasia. In particular, patients who had a large (>1.0 cm) adenoma with severe dysplasia at baseline had a relative risk of 37 (7.8-174.7) of developing advanced metachronous neoplasms compared with patients who had small adenoma(s) with mild dysplasia.
  
  
  CONCLUSIONS
  The risk of metachronous adenomas is closely related to the pathology of initial adenomas, thus allowing identification of a high-risk group of adenoma patients for close surveillance after their initial polypectomy.
authors.affiliation: Cancer Institute of Zhejiang Medical University, Hangzhou, People's Republic of China.
authors.forename: G
authors.initials: G
authors.lastname: Yang
authors.forename: W
authors.initials: W
authors.lastname: Zheng
authors.forename: Q R
authors.initials: QR
authors.lastname: Sun
authors.forename: X O
authors.initials: XO
authors.lastname: Shu
authors.forename: W D
authors.initials: WD
authors.lastname: Li
authors.forename: H
authors.initials: H
authors.lastname: Yu
authors.forename: G F
authors.initials: GF
authors.lastname: Shen
authors.forename: Y Z
authors.initials: YZ
authors.lastname: Shen
authors.forename: J D
authors.initials: JD
authors.lastname: Potter
authors.forename: S
authors.initials: S
authors.lastname: Zheng
mesh_terms: D000236:Adenoma / Q000473:pathology*; D000328:Adult; D002681:China; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000175:diagnosis*; D011237:Predictive Value of Tests; D012004:Rectal Neoplasms / Q000473:pathology*; D012306:Risk; D012720:Severity of Illness Index; D012812:Sigmoidoscopy