Neuromuscular responses to pyridostigmine bromide in organotypic spinal cord-muscle culture.
Pyridostigmine bromide (PB) promotes and then silences cholinergic muscle activity, and disrupts the junctional regions of muscle fibers and associated nerve terminals, in organotypic mouse spinal cord-muscle cultures continuously treated with low concentrations of the drug for up to 14 days. Spontaneous muscle activity is restored within 1 week of drug removal.
Drake-Baumann
R
R
Department of Veterans, Affairs Medical Center, Portland, Oregon, USA.
Seil
F J
FJ
Spencer
P S
PS
D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D051379:Mice; D009469:Neuromuscular Junction / Q000187:drug effects*; D009498:Neurotoxins / Q000494:pharmacology*; D009924:Organ Culture Techniques; D011729:Pyridostigmine Bromide / Q000494:pharmacology*; D013116:Spinal Cord / Q000187:drug effects*
D002800:Cholinesterase Inhibitors; D009498:Neurotoxins; D011729:Pyridostigmine Bromide