[A study on neurotoxicity of acrylamide and glycidamide].
Glycidamide (GA) is an epoxide metabolite of acrylamide (AA). Neurotoxicity of both GA and AA was compared by their performance in behavioral, neuro-biochemical and neuropathological studies. Male rats were injected peritoneally with AA (25 or 50 mg/kg) or GA (50 or 100 mg/kg) once daily for eight days. Results showed that toxic effects of AA were greater than those of GA in wheel rotation test, hind limb splay test, and activities of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in peripheral nerves in rats. Results of neuropathological examinations in experimental rats also provided evidence that AA could cause damage to peripheral nerves, but GA did not. It indicated that nerve tissue was more vulnerable to AA than to GA. Also, it suggested that neurotoxic effects of AA was caused by itself, and influenced less by its metabolite GA.
Deng
H
H
Institute of Occupational Health, Chinese Academy of Preventive Medicine, Beijing.
Jiao
X
X
He
F
F
D000178:Acrylamides / Q000633:toxicity*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004852:Epoxy Compounds / Q000633:toxicity*; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000378:metabolism; D008297:Male; D010446:Peptide Fragments / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000473:pathology
D000178:Acrylamides; D004852:Epoxy Compounds; D010446:Peptide Fragments; C068142:glyceraldehyde 3-phosphate dehydrogenase (304-313); C071834:glycidamide; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases