[Effect of dorsal raphe nucleus stimulation on unit discharges of light-sensitive neurons of suprachiasmatic nucleus in rats].
The effect of dorsal raphe nucleus (DR) stimulation on the unit discharge of suprachiasmatic nucleus (SCN) neurons was studied and analyzed pharmacologically in the Wistar rats. Experimental results showed that DR stimulation could significantly inhibit the light-induced discharge of SCN neurons. Pharmacologically, this inhibition could be enhanced by monoamine oxidase inhibitor pargyline, attenuated by 5-hydroxytryptamine (5-HT) synthesis inhibitor parachlorophenylalanine and blocked by 5-HT receptor antagonist cyproheptadine. It was suggested that the inhibitory effect of DR stimulation on the light-sensitive SCN neuron discharge might be mediated by 5-HT.
Yu
G D
GD
Laboratory of Neurobiology, Suzhou Medical College.
Wei
X P
XP
Zhang
H Q
HQ
Xu
S
S
Yin
Q Z
QZ
Tang
P L
PL
Qian
Z M
ZM
D000818:Animals; D003533:Cyproheptadine / Q000494:pharmacology; D004594:Electrophysiology; D005260:Female; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D009474:Neurons / Q000502:physiology; D010293:Pargyline / Q000494:pharmacology; D010775:Photic Stimulation; D011903:Raphe Nuclei / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000494:pharmacology; D013493:Suprachiasmatic Nucleus / Q000502:physiology*
D008996:Monoamine Oxidase Inhibitors; D012702:Serotonin Antagonists; D003533:Cyproheptadine; D012701:Serotonin; D010293:Pargyline