Molecular interactions of acetylcholinesterase with senile plaques.
Acetylcholinesterase (AChE) present in Alzheimer plaques is resistant to low pH, anti-ChE inhibitors and high substrate concentrations in comparison with the free enzyme. Kinetic and pharmacological studies of AChE-amyloid complexes indicate that steric hindrance by the amyloid over the gorge and the peripheral site of AChE is responsible for these effects.
Inestrosa
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Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.
Alarcón
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R
D000110:Acetylcholinesterase / Q000502:physiology*; D000544:Alzheimer Disease / Q000201:enzymology / Q000473:pathology; D000818:Animals; D006801:Humans; D058225:Plaque, Amyloid / Q000201:enzymology*
D000110:Acetylcholinesterase