In vitro activity of sertaconazole against Malassezia furfur and pachydermatis in different culture media.
The activity of sertaconazole against Malassezia furfur and pachydermatis was tested in different culture media in order to elucidate the factors that can influence its activity. The addition to the culture media of lipids, which are necessary for M. furfur to grow, was found to decrease the activity of this antifungal to a great extent. Since the aim of in vitro drug testing is to provide representative data of its activity which must be indicative for its clinical efficacy, and in view of the good clinical response of M. furfur infection to sertaconazole, it is concluded that the activity of this antifungal against M. furfur cannot be determined by the in vitro data provided by conventional methods due to such influential factors.
Palacin
C
C
Department of Microbiology, Centro de Investigacion Grupo Ferrer, Barcelona, Spain.
Tarragó
C
C
Ortiz
J A
JA
D000935:Antifungal Agents / Q000494:pharmacology*; D003470:Culture Media; D007093:Imidazoles / Q000494:pharmacology*; D008290:Malassezia / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D013876:Thiophenes / Q000494:pharmacology*
D000935:Antifungal Agents; D003470:Culture Media; D007093:Imidazoles; D013876:Thiophenes; C061131:sertaconazole