title: Renal growth characteristics in children born with multicystic dysplastic kidneys.
abstract: OBJECTIVE
  To report on the growth characteristics of the affected and contralateral kidneys in children born with multicystic dysplastic kidneys (MCDKs).
  
  
  METHODS
  Thirty-three patients were enrolled from 1970 to 1995: 23 were initially managed nonoperatively (mean follow-up 3.39 years), and 10 underwent nephrectomy. Patients underwent radionuclide renal imaging and contrast voiding cystography. Serial ultrasonography was used to obtain measurements of the affected and contralateral kidneys. Blood pressure measurements and serum creatinine levels were available in some patients.
  
  
  RESULTS
  Among the 23 nonoperative patients, the affected MCDK involuted in 4 patients during a mean follow-up of 4.5 years at a rate of 1.02 cm/yr (24% annually); 7 kidneys decreased in size at a mean rate of 0.38 cm/yr (5.8% annually); 6 grew at a mean rate of 1.16 cm/yr (9.9% annually); 1 kidney did not change in size; and 5 children were lost to follow-up. The mean size of the contralateral kidneys at birth was 5.3 cm, 2 standard deviations larger than normal. Over time, this relative hypertrophy was maintained at a growth rate of 0.89 cm/yr (18.5% annually). Two patients who had undergone nephrectomy also had serial postoperative ultrasonic renal measurements, and contralateral growth was 0.61 cm/yr (12.16% annually). All but 1 patient had normal blood pressure measurements and serum creatinine levels.
  
  
  CONCLUSIONS
  Most MCDKs involute or decrease in size over time, although this may take many years. Contralateral hypertrophy is seen at birth and is maintained during childhood growth, regardless of whether the affected kidney is removed. There is no associated hypertension or malignancy when the dysplastic kidney is left in place.
authors.affiliation: Department of Pediatric Urology, State University of New York at Buffalo School of Medicine, Children's Hospital of Buffalo, 14222, USA.
authors.forename: R
authors.initials: R
authors.lastname: White
authors.forename: S P
authors.initials: SP
authors.lastname: Greenfield
authors.forename: J
authors.initials: J
authors.lastname: Wan
authors.forename: L
authors.initials: L
authors.lastname: Feld
mesh_terms: D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007668:Kidney / Q000002:abnormalities / Q000254:growth & development*; D007690:Polycystic Kidney Diseases / Q000151:congenital* / Q000503:physiopathology*