[Remarkable increase of CD8+ CD11a+ and CD8+ CD57- T cells in patients with post-transfusion graft-versus-host disease].
We analyzed the distribution of two T cell subsets, CD8+ CD11a+ (CD8+ cytotoxic effector population) and CD8+ CD57- cells, in the peripheral lymphocytes of 3 post-operative patients with post-transfusion graft-versus-host disease (PT-GVHD) and 5 post-operative patients without PT-GVHD. The percentage of CD8+ CD11a+ cells in the PT-GVHD-negative control was 19 +/- 4%, and in the 3 patients with PT-GVHD, 69%, 66%, and 59%, respectively. The percentage of CD8+ CD57- cells in the PT-GVHD-negative control was 19 +/- 6%, and in the 3 PT-GVHD patients, 59%, 58%, and 55%, respectively. Significantly higher proportions of the two T cell subsets were consistently observed in the patients with PT-GVHD than in the PT-GVHD-negative control. These results suggest that the analysis of CD8+ T cell subsets may be useful for the simple and rapid laboratory diagnosis of PT-GVHD.
Karasuno
T
T
Fifth Department of Medicine, Osaka Medical Center for Cancer and Cardiovascular Diseases.
Nakamura
H
H
Fukuda
H
H
Okajima
Y
Y
Maeda
T
T
Teshima
H
H
Hiraoka
A
A
Masaoka
T
T
D000208:Acute Disease; D000368:Aged; D018959:CD57 Antigens; D018414:CD8-Positive T-Lymphocytes; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology / Q000276:immunology*; D006801:Humans; D016169:Lymphocyte Function-Associated Antigen-1; D008297:Male; D016176:T-Lymphocyte Subsets; D065227:Transfusion Reaction
D018959:CD57 Antigens; D016169:Lymphocyte Function-Associated Antigen-1