Focal grey matter heterotopias in monozygotic twins with developmental language disorder.
We describe 9-year-old monozygotic male twins with a developmental language disorder of the phonologic-syntactic type and learning difficulties. High-resolution MRI revealed bilateral parieto-temporal grey matter heterotopias in both twins, on the left more than on the right, and more pronounced in the more affected twin. This suggests a causal relationship between the heterotopias and the neuropsychological findings in this twin pair.


CONCLUSIONS
Neuronal migration defects and ensuing focal heterotopias may be causally related to developmental language disorders.
Preis
S
S
Department of Paediatrics, University of Düsseldorf, Germany.
Engelbrecht
V
V
Huang
Y
Y
Steinmetz
H
H
D002540:Cerebral Cortex / Q000473:pathology*; D002648:Child; D002828:Choristoma / Q000473:pathology*; D004200:Diseases in Twins; D006801:Humans; D007806:Language Disorders / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000473:pathology; D013702:Temporal Lobe / Q000473:pathology; D014430:Twins, Monozygotic