title: [The physicochemical characterization of the strains isolated during the outbreak of epidemic neuropathy in Cuba. II].
abstract: The presence of 2 agents such as a Cox A9 strain and another mild cytopathogenic effect-producing strain, both isolated from patients presenting with epidemic neuropathy is reported in this paper. A mild cutopathogenic effect which was propagated in successive dilutions was developed in the dilution 10(-4) by means of the neutralization test of a Coxsackie A9 virus with its homologous hyperimmune serum. A gradient in saccharose was performed in a mild cytopathogenic effect-producing strain and a typical cytopathogenic effect of an Enterovirus developed from one of the fractions passed in tissular cultures in the presence phosphonoacetic acid (PAA). The possible pathogenic role of these viruses are discussed.
authors.affiliation: Instituto de Medicina Tropical Pedro Kourí.
authors.forename: M G
authors.initials: MG
authors.lastname: Guzman
authors.forename: S
authors.initials: S
authors.lastname: Resik
authors.forename: C
authors.initials: C
authors.lastname: Sariol
authors.forename: R
authors.initials: R
authors.lastname: Rodríguez
authors.forename: M
authors.initials: M
authors.lastname: Alvarez
authors.forename: L
authors.initials: L
authors.lastname: Morier
authors.forename: A
authors.initials: A
authors.lastname: Castillo
authors.forename: G
authors.initials: G
authors.lastname: Kourí
authors.forename: P
authors.initials: P
authors.lastname: Más
mesh_terms: D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002522:Chlorocebus aethiops; D003462:Cuba / Q000453:epidemiology; D003588:Cytopathogenic Effect, Viral; D004770:Enterovirus / Q000737:chemistry* / Q000187:drug effects / Q000302:isolation & purification / Q000472:pathogenicity; D006801:Humans; D009902:Optic Neuritis / Q000453:epidemiology / Q000821:virology*; D010523:Peripheral Nervous System Diseases / Q000453:epidemiology / Q000821:virology*; D012692:Serial Passage; D014709:Vero Cells