Lupus anticoagulant antibodies: recognition of phospholipid-binding protein complexes.
Lupus anticoagulant antibodies form a heterogeneous group of antiphospholipid antibodies with rather poorly defined antigens. The role that phospholipid-binding proteins play in lupus anticoagulant antibody activity is a subject of current investigation. Several candidate proteins have been proposed, including beta2-glycoprotein I (beta2GPI), prothrombin, and annexin V. As beta2GPI-dependent lupus anticoagulants will be reviewed elsewhere in this issue, this paper will focus on the involvement of prothrombin and annexin V in lupus anticoagulant activity. Evidence for a role for these proteins in the reactivity and induction of lupus anticoagulant antibodies will be discussed, as well as an apparent requirement for both phospholipid and phospholipid-binding protein. The data presented here suggest that some lupus anticoagulant antibodies recognize and may be induced by complexes of phospholipid and phospholipid-binding proteins, in particular, phospholipid and prothrombin or annexin V.
Rauch
J
J
Department of Medicine, The Montreal General Hospital Research Institute, McGill University, Quebec, Canada.
D000818:Animals; D017304:Annexin A5 / Q000276:immunology* / Q000378:metabolism; D000911:Antibodies, Monoclonal / Q000276:immunology; D016736:Antiphospholipid Syndrome / Q000276:immunology; D001324:Autoantigens / Q000276:immunology* / Q000378:metabolism; D001327:Autoimmune Diseases / Q000276:immunology; D002417:Cattle; D006023:Glycoproteins / Q000276:immunology / Q000378:metabolism; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000276:immunology* / Q000378:metabolism; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D046911:Macromolecular Substances; D051379:Mice; D008807:Mice, Inbred BALB C; D010714:Phosphatidylethanolamines / Q000276:immunology / Q000378:metabolism; D010743:Phospholipids / Q000276:immunology* / Q000378:metabolism; D011485:Protein Binding; D011516:Prothrombin / Q000276:immunology* / Q000378:metabolism; D019851:Thrombophilia / Q000276:immunology; D053482:beta 2-Glycoprotein I
D017304:Annexin A5; D000911:Antibodies, Monoclonal; D001324:Autoantigens; D006023:Glycoproteins; D016682:Lupus Coagulation Inhibitor; D046911:Macromolecular Substances; D010714:Phosphatidylethanolamines; D010743:Phospholipids; D053482:beta 2-Glycoprotein I; D011516:Prothrombin