Synthesis and antimicrobial activity of a dihydroampicillin and a dihydrocephalexin.
A dihydroampicillin (3) and a dihydrocephalexin (4) have been synthesized by condensing alpha-(cyclohexa-1, 3-dienyl)glycyl chloride with 6-aminopenicillanic acid (1) and 7-deacetoxycephalosporanic acid (2) respectively. The two antibiotics obtained show enhanced antimicrobial activity towards certain bacterial strains compared with ampicillin and cephalexin.
Hashem
A I
AI
Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
Shaban
M E
ME
Abdel-Aziz
R
R
Abdel-Nasser
G
G
D000667:Ampicillin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D002506:Cephalexin / Q000138:chemical synthesis* / Q000494:pharmacology; D002511:Cephalosporins / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000138:chemical synthesis* / Q000494:pharmacology
D002511:Cephalosporins; D010406:Penicillins; C100212:epicillin; D000667:Ampicillin; D002506:Cephalexin