Correlation of prostaglandin E2 production and gastric acid secretion in infants with hypertrophic pyloric stenosis.
OBJECTIVE
The aim of this study was to evaluate the relationship between gastric acid secretion and prostaglandin E2 (PGE2) generation in gastric mucosa and the role of PGE2 in the pathogenesis of hypertrophic pyloric stenosis (HPS).


METHODS
The authors measured the levels of PGE2 and gastric acidity in the gastric juice of HPS patients before and after a Ramstedt operation.


RESULTS
The PGE2 concentration in the gastric juice of nine HPS patients before the Ramstedt operation was significantly higher than that of eight controls, and the concentration significantly decreased after the operation. A significant inverse correlation between the PGE2 concentration and the pH level in the gastric juice was shown in HPS patients before and after the operation.


CONCLUSIONS
These results suggest that the enhanced generation of PGE2 in gastric mucosa in cases of HPS is a secondary phenomenon caused by hyperacidity and is not responsible for the pathogenesis of HPS.
Shinohara
K
K
Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan.
Shimizu
T
T
Igarashi
J
J
Yamashiro
Y
Y
Miyano
T
T
D015232:Dinoprostone / Q000096:biosynthesis*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005750:Gastric Juice / Q000737:chemistry; D006801:Humans; D006984:Hypertrophy; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011707:Pyloric Stenosis / Q000378:metabolism* / Q000601:surgery
D015232:Dinoprostone