Secretin and gastric lipase secretion.
BACKGROUND
Gastric lipase secretion is stimulated by gastrin in plasma, but its regulation by secretin is unknown.


METHODS
In 7 normal persons we investigated the effect of exogenous secretin on the output of gastric lipase stimulated by intravenous gastrin-17. The gastric content was measured using a nasogastric tube for aspiration. The quantitative lipase secretion was measured by an enzyme-linked immunosorbant assay (ELISA) and the lipolytic activity by a kinetic assay. Plasma concentrations of secretin and gastrin were measured by radioimmunoassay.


RESULTS
Gastric lipase secretion (the quantity as well as the lipolytic activity) was significantly stimulated by gastrin. In response to secretin infusion, the lipolytic activity increased as acid secretion decreased.


CONCLUSIONS
Secretin in postprandial concentrations does not influence the quantitative gastric lipase secretion stimulated by gastrin, but it increases lipolytic activity due to inhibition of acid secretion.
Olsen
O
O
Department of Surgery D, Glostrup Hospital, University of Copenhagen, Sweden.
Wøjdemann
M
M
Berner
B
B
Christiansen
G
G
Sternby
B
B
D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005750:Gastric Juice / Q000201:enzymology*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D005755:Gastrins / Q000008:administration & dosage / Q000097:blood; D006801:Humans; D007262:Infusions, Intravenous; D008049:Lipase / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D012016:Reference Values; D012633:Secretin / Q000097:blood / Q000494:pharmacology*
D005755:Gastrins; D012633:Secretin; C013550:gastrin 17; D008049:Lipase