Antimicrobial susceptibility of bacteria isolated from orthopedic implants following revision hip surgery.
The susceptibilities of 49 isolates recovered from orthopedic implants to seven antimicrobial agents were evaluated by the broth microdilution method. Ciprofloxacin and vancomycin were more active than gentamicin, representing aminoglycosides which are routinely incorporated into bone cement, and also more active than the peroperative antimicrobial agents cefamandole and erythromycin. The use of ciprofloxacin and vancomycin in vivo, therefore, warrants further evaluation.
Tunney
M M
MM
Department of Microbiology and Immunobiology, School of Clinical Medicine, The Queen's University of Belfast, Belfast BT12 6BN, Belfast BT9 7BL, United Kingdom.
Ramage
G
G
Patrick
S
S
Nixon
J R
JR
Murphy
P G
PG
Gorman
S P
SP
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D001419:Bacteria / Q000187:drug effects*; D002435:Cefamandole / Q000494:pharmacology; D002939:Ciprofloxacin / Q000494:pharmacology; D004917:Erythromycin / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D014640:Vancomycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D002435:Cefamandole; D002939:Ciprofloxacin; D004917:Erythromycin; D014640:Vancomycin