WT1--more than a transcription factor?
The Wilms tumor-suppressor gene WT1 was originally identified through its involvement in the development of a pediatric kidney tumor. Recent genetic data show that mutations in the WT1 gene cause a variety of other diseases, and new biochemical evidence suggests that the WT1 protein is not only a transcription factor but might also act at the post-transcriptional level.
Englert
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Research Center Karlsruhe, Institute of Genetics, Karlsruhe, Germany. Christoph.englert@igen.fzk.de
D017398:Alternative Splicing; D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D016162:Genes, Wilms Tumor; D006801:Humans; D007668:Kidney / Q000002:abnormalities / Q000196:embryology; D051379:Mice; D018345:Mice, Knockout; D009154:Mutation; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*; D025721:WT1 Proteins
D004268:DNA-Binding Proteins; D014157:Transcription Factors; D025721:WT1 Proteins