Application of derivative spectrophotometry for determination of coenzyme Q10 in pharmaceuticals and plasma.
The use of derivative spectrophotometry is proposed in this work for determination of coenzyme Q10 in formulations and in human plasma. The spectrophotometric procedure is simpler and less expensive than chromatographic techniques commonly used for the analysis of coenzyme. The active compound can be determined in the range 0.25-10 ppm for standard solutions and pharmaceuticals and 0.05-1.5 ppm in plasma. The proposed method was applied for coenzyme determination in real samples. The results agree well with declared value and with these obtained by HPLC.
Karpińska
J
J
University of Białystok, Białystock Branch, Poland.
Mikołuć
B
B
Piotrowska-Jastrzebska
J
J
D000975:Antioxidants / Q000032:analysis*; D002214:Capsules; D002851:Chromatography, High Pressure Liquid; D003067:Coenzymes; D006801:Humans; D013053:Spectrophotometry / Q000295:instrumentation / Q000379:methods*; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood
D000975:Antioxidants; D002214:Capsules; D003067:Coenzymes; D014451:Ubiquinone; C024989:coenzyme Q10