BEHAB/brevican: a brain-specific lectican implicated in gliomas and glial cell motility.
Several recent findings have advanced our understanding of the composition and function of the brain extracellular matrix (ECM). BEHAB/brevican, a recently identified CNS-specific proteoglycan, is a component of the brain ECM and is upregulated during glial cell motility. It is expressed at high levels during development, in response to injury, and in primary brain tumors. Cleavage of the BEHAB/brevican protein may increase invasion of tumor cells.
Gary
S C
SC
Section of Neurobiology, Yale University, New Haven, Connecticut 06520-8001, USA. sydney.gary@yale.edu
Kelly
G M
GM
Hockfield
S
S
D001923:Brain Chemistry / Q000502:physiology; D001932:Brain Neoplasms / Q000378:metabolism*; D058581:Brevican; D002352:Carrier Proteins / Q000235:genetics*; D002465:Cell Movement / Q000502:physiology; D011508:Chondroitin Sulfate Proteoglycans / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D005910:Glioma / Q000378:metabolism*; D006801:Humans; D037102:Lectins; D037181:Lectins, C-Type; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009457:Neuroglia / Q000166:cytology*
C546938:BCAN protein, human; D058581:Brevican; D002352:Carrier Proteins; D011508:Chondroitin Sulfate Proteoglycans; D037102:Lectins; D037181:Lectins, C-Type; D009419:Nerve Tissue Proteins