Follicular center cell lymphoma with an extremely high content of T cells: case report with useful diagnostic techniques.
Follicular center cell lymphomas often contain a prominent population of T cells, most commonly in the interfollicular regions and with a helper immunophenotype. We report a case of follicular center cell lymphoma (follicular, mixed cell types) with a prominent population of T cells (normal CD4-CD8 ratio) in both the interfollicular and follicular regions. The prominent T-cell population resulted in misleading flow cytometric immunophenotypic findings. Immunoperoxidase stains (L-26, LN-2, and Bcl-2) confirmed the neoplastic follicular center cell origin and aided in subclassification.
Dunphy
C H
CH
Department of Pathology, St Louis (MO) University Health Sciences Center, 63104, USA.
Lattuada
C P
CP
D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D018655:Lymphocyte Count; D008224:Lymphoma, Follicular / Q000473:pathology*; D008875:Middle Aged; D013601:T-Lymphocytes / Q000473:pathology*