Management of intracranial aneurysms: "state of the art".
The authors provide an overview of the past, present and future of intracranial aneurysms management. Excellent results achieved today by neurovascular surgeons are to be ascribed not only to refinements in microsurgical technique but also to an always more aggressive and effective treatment of vasospasm, the most feared complication of aneurysmal SAH. "Triple H" therapy, calcium channel blockers, rTPA and balloon angioplasty represent the corner-stones of arterial spasm treatment. Hopefully new agents such as lazaroids, endothelins inhibitors and nitric oxyde modulators will become available for clinical use in the next future. Although clipping of aneurysmal neck is still considered the "gold standard", obliteration of the aneurysmal sac can now be safely achieved by coil embolization: the exact role and respective indications of each technique are yet to be defined. Further prognostic improvement will be possible through an early diagnosis, i.e. before the occurrence of SAH, as shown by negligible morbidity and mortality associated with the treatment of "incidental" and "unruptured" aneurysms.
Chiappetta
F
F
Department of Neurosciences G. M. Lancisi, S. Camillo Hospital, Rome, Italy.
Brunori
A
A
Bruni
P
P
D004621:Embolization, Therapeutic; D016166:Free Radical Scavengers / Q000627:therapeutic use; D006801:Humans; D002532:Intracranial Aneurysm / Q000601:surgery / Q000628:therapy*; D009462:Neurology / Q000639:trends*; D010208:Papaverine / Q000627:therapeutic use; D015912:Thrombolytic Therapy
D016166:Free Radical Scavengers; D010208:Papaverine