[A study on the inhibitory effects of several chemicals on the production of nitrogen oxide in alveolar macrophage induced by asbestos].
Induction of chrysotile produced in Mang ai to the production of nitrogen oxide (NO) and effects of mixed rare earths (MRE), sodium selenite (SS) and aluminium citrate on the production of NO in alveolar macrophage (AM) induced by asbestos fiber were observed by in vitro cell culture technique and determination of nitrite ion content in the culture medium. Results showed that chrysotile fiber could increase nitrite ion content in the culture medium, with an obvious dose-dependent relationship. MRE, selenite, and aluminium citrate all could inhibit the production of NO in AM induced by asbestos, and its inhibitiory effects increased with the concentration of the above-mentioned chemicals. It suggests antagonism of MRE and selenite to pathogenicity of asbestos may be used in practice.
Fan
J
J
Department of Labor Hygiene, School of Public Health, Beijing Medical University.
Wang
Q
Q
Wu
W
W
D017607:Aluminum Compounds / Q000494:pharmacology; D000818:Animals; D001194:Asbestos / Q000009:adverse effects*; D006168:Guinea Pigs; D016676:Macrophages, Alveolar / Q000378:metabolism*; D008297:Male; D008674:Metals, Rare Earth / Q000494:pharmacology*; D019016:Mineral Fibers / Q000009:adverse effects; D009569:Nitric Oxide / Q000096:biosynthesis*; D018038:Sodium Selenite / Q000494:pharmacology*
D017607:Aluminum Compounds; D008674:Metals, Rare Earth; D019016:Mineral Fibers; D001194:Asbestos; D009569:Nitric Oxide; D018038:Sodium Selenite