DNA repair: knockouts still mutating after first round.
Recent studies have investigated whether particular DNA repair pathways are involved in the somatic hypermutation mechanism that increases antibody diversity. The primary mutation mechanism still functions in mice carrying knockouts of all repair genes examined, but mismatch repair defects affect the final outcome.
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Imperial Cancer Research Fund Clare Hall Laboratories South Mimms, Hertfordshire, EN6 3LD, UK.
D000818:Animals; D020029:Base Pairing / Q000235:genetics; D004260:DNA Repair / Q000235:genetics*; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D016296:Mutagenesis