title: Comparison of lytic cocktail and magnesium sulphate regimens in eclampsia: a retrospective analysis.
abstract: Retrospective analysis of eclamptic patients was done during two time periods. In time period A (Jan. 1987-Dec. 1988), 79 patients of eclampsia were treated with lytic cocktail and in time period B (April 1992-April 1994), 104 eclamptic patients were treated with magnesium sulfate. The severity of disease, details of labour, delivery, incidence of persistent convulsions and the maternal and perinatal outcomes were compared. Incidence of persistent convulsions was significantly lower with magnesium sulphate (4.8%) compared to lytic cocktail (26.6%). No difference was observed in duration of labour and mode of delivery. Perinatal mortality was significantly lower in magnesium sulphate treated group. Maternal mortality was similar in both the groups (lytic cocktail-3.8%, Magnesium sulphate-2.9%).
authors.affiliation: Department of Obstetrics and Gynaecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: H
authors.initials: H
authors.lastname: Sawhney
authors.forename: K
authors.initials: K
authors.lastname: Vasishta
authors.forename: K
authors.initials: K
authors.lastname: Rani
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000494:pharmacology / Q000627:therapeutic use; D000927:Anticonvulsants / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000502:physiology; D002491:Central Nervous System Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002746:Chlorpromazine / Q000494:pharmacology / Q000627:therapeutic use; D018492:Dopamine Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D004338:Drug Combinations; D004461:Eclampsia / Q000188:drug therapy*; D005260:Female; D005865:Gestational Age; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology / Q000627:therapeutic use; D008278:Magnesium Sulfate / Q000494:pharmacology / Q000627:therapeutic use*; D008614:Meperidine / Q000494:pharmacology / Q000627:therapeutic use; D011247:Pregnancy; D011256:Pregnancy Outcome; D011398:Promethazine / Q000494:pharmacology / Q000627:therapeutic use; D012189:Retrospective Studies; D012640:Seizures / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D000701:Analgesics, Opioid; D000927:Anticonvulsants; D002491:Central Nervous System Agents; D018492:Dopamine Antagonists; D004338:Drug Combinations; D006993:Hypnotics and Sedatives; D008278:Magnesium Sulfate; D008614:Meperidine; D011398:Promethazine; D002746:Chlorpromazine