title: Trabeculectomy with long-term-stored mitomycin C in West Indian population.
abstract: We investigated the outcome of trabeculectomy with stored mitomycin C (MMC) in a black Caribbean population on the island of Dominica. Ten eyes (9 patients) underwent trabeculectomy with MMC (0.5 mg/ml for 3-6 min) that had been stored for up to 17 months at 4 degrees C. The preoperative intraocular pressure of (mean +/- SD) 32.8+/-7.5 mm Hg on 2.6 medications decreased to 9.5+/-3.2 mm Hg on 0.2 medications after a mean follow-up time of 14.2 months (range 7-25). Nine eyes did not receive medications postoperatively. Complications observed included bleb infection (1 eye) and late bleb leak (1 eye); 2 eyes developed cataract. Nine blebs had typical clinical features of blebs after trabeculectomy with adjunctive MMC. We conclude that long-term-stored MMC may be beneficial as adjunctive treatment in initial trabeculectomy in this population.
authors.affiliation: Department of Ophthalmology, University of Washington, Seattle, Wash. , USA. pchen@u.washington.edu
authors.forename: P P
authors.initials: PP
authors.lastname: Chen
authors.forename: F M
authors.initials: FM
authors.lastname: Basich
authors.forename: E
authors.initials: E
authors.lastname: Khadem
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D004356:Drug Storage; D005260:Female; D005901:Glaucoma / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use*; D019384:Nucleic Acid Synthesis Inhibitors / Q000627:therapeutic use*; D011184:Postoperative Period; D013997:Time Factors; D014130:Trabeculectomy; D014792:Visual Acuity / Q000502:physiology; D014900:West Indies
chemical_list: D019384:Nucleic Acid Synthesis Inhibitors; D016685:Mitomycin