[Effect of microinjection of adrenaline (E) into the rostral ventrolateral medulla on the parameters of the hemorrheology].
Experiments were performed on SD rats. It was found that hyperviscosity could be induced by restrained conscious rats. Microinjection of adrenaline (E) into the rostral ventrolateral medulla (rVLM) resulted in a facilitatory increase in blood viscosity, which was blocked by bilateral microinjection of alpha-adrenoceptor antagonist (phentola mine) into the same area, but not by beta-adrenocetor antagonist (propranolol). Pretreatment of rVLM area with 6-hydroxydopamine (6-OHDA) or microinjection of phentolamine abolished stress-induced hyperviscosity, while propranolol was without effect. Apparently the E caused increase of the blood viscosity or stress-induced hyperviscosity may be mediated by activation of alpha-adrenoceptor in the rVLM.
Wang
S H
SH
Department of Physiology, Shanghai Medical University.
Guo
X Q
XQ
D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects*; D004837:Epinephrine / Q000494:pharmacology*; D008297:Male; D008526:Medulla Oblongata / Q000502:physiology*; D008845:Microinjections; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D011942:Receptors, Adrenergic, alpha / Q000502:physiology; D013312:Stress, Physiological
D011942:Receptors, Adrenergic, alpha; D004837:Epinephrine