title: Wound healing around endosseous implants in experimental diabetes.
abstract: Wound healing has been shown to be altered in diabetes mellitus. The aim of this study was to identify the effects of streptozotocin-induced diabetes on osseointegration. Diabetes was induced in 40-day-old rats by intraperitoneal injection of 70 mg per kg streptozotocin. At 14 days postinjection, implants were placed in the femora of 10 diabetic and 10 age-matched normal rats. Animals were sacrificed at 28 and 56 days following implantation. Histometric results indicated that the quantity of bone formation was similar for diabetic and control animals (P > .05). However, less bone-implant contact was observed for diabetic compared to control animals at both 28 and 56 days (P < .0001). This study demonstrates that the process of osseointegration is affected by streptozotocin-induced diabetes.
authors.affiliation: Department of Periodontology, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA. jfiorell@warren.med.harvard.edu
authors.forename: M L
authors.initials: ML
authors.lastname: Nevins
authors.forename: N Y
authors.initials: NY
authors.lastname: Karimbux
authors.forename: H P
authors.initials: HP
authors.lastname: Weber
authors.forename: W V
authors.initials: WV
authors.lastname: Giannobile
authors.forename: J P
authors.initials: JP
authors.lastname: Fiorellini
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000503:physiopathology*; D005269:Femur; D020007:Implants, Experimental; D008297:Male; D016348:Osseointegration / Q000502:physiology*; D010012:Osteogenesis / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D018709:Statistics, Nonparametric; D013311:Streptozocin; D014945:Wound Healing / Q000502:physiology
chemical_list: D015921:Dental Implants; D013311:Streptozocin