title: Giant-cell tumor in soft parts in a patient with osseous Paget's disease: diagnosis by fine-needle aspiration.
abstract: In this report, the cytological features and differential diagnosis of a case of giant-cell tumor (GCT) in soft tissues in a patient with osseous Paget's disease (PD) are described, with histological confirmation. Characteristic cytological findings include a diffuse cellular population of neoplastic cells composed of two types: one group of polygonal or round mononuclear small cells, exhibiting a thin-rim, dense cytoplasm and single hyperchromatic nuclei; and the second group of multinucleated, osteoclast-type giant cells with dozens of round nuclei, showing occasional micronucleoli. A prominent feature is the presence of numerous capillary structures surrounded by tumor cells. The differential diagnosis includes a number of other neoplastic and reactive processes in which giant cells may be abundant. The cytological features of GCT appear to be characteristic enough to allow a suggestive diagnosis. However, the final diagnosis should be made only after the lesion has been studied histologically.
authors.affiliation: Sección de Citología, Hospital Juan Canalejo, La Coruña, Spain. Ignacio_Galed@canalejo.cesga.es
authors.forename: I
authors.initials: I
authors.lastname: Galed-Placed
authors.forename: E
authors.initials: E
authors.lastname: García-Ureta
authors.forename: M
authors.initials: M
authors.lastname: Sánchez-Blas
authors.forename: M
authors.initials: M
authors.lastname: Lago-Novoa
mesh_terms: D000368:Aged; D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D005870:Giant Cell Tumors / Q000000981:diagnostic imaging / Q000473:pathology*; D015726:Giant Cells / Q000473:pathology; D006801:Humans; D008297:Male; D010001:Osteitis Deformans / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D010010:Osteoclasts / Q000473:pathology; D010388:Pelvis / Q000000981:diagnostic imaging; D012983:Soft Tissue Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed