title: Chronic plasma cell endometritis in hysterectomy specimens of HIV-infected women: a retrospective analysis.
abstract: OBJECTIVE
  Abnormal uterine bleeding is a common and troublesome problem in human immunodeficiency virus (HIV)-infected women. We sought to evaluate endometrial pathology among HIV-infected women requiring hysterectomy to explore if endometritis may be common among these patients.
  
  
  METHODS
  We performed a retrospective analysis of uterine pathology specimens obtained from HIV-infected and control patients requiring hysterectomy in two urban hospitals between 1988 and 1997 matched for age, surgical indication, and history of gonadotropin-releasing hormone (GnRH) use. Cases were evaluated for the presence of plasma cells and assigned a grade between 0 and 3.
  
  
  RESULTS
  Indications included cervical dysplasia (4), carcinoma in situ (2), abnormal uterine bleeding (3), and adnexal mass (3). Some degree of abnormal uterine bleeding occurred in all cases. Plasma cell endometritis was twice as common in HIV-infected women compared to HIV-negative specimens (11/11 versus 11/22) (P < 0.05). Plasma cell endometritis was also of a higher grade in specimens from HIV-infected women than in controls (P = 0.001).
  
  
  CONCLUSIONS
  Chronic endometritis was common and of a higher grade among HIV-infected women requiring hysterectomy in our series. Diagnosis and treatment of endometritis should be considered in HIV-infected women with uterine bleeding and/or tenderness. We speculate that antiretroviral and/or antimicrobial treatment for endometritis may effectively treat endometritis and eliminate the need for surgery in some HIV-infected women. We suggest that consideration and treatment of endometritis in HIV-1 infected women being evaluated for possible hysterectomy has the potential to reduce costs and morbidity for patients and providers who may be exposed during surgical procedures.
authors.affiliation: Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Denver Health Medical Center, CO, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Kerr-Layton
authors.forename: C A
authors.initials: CA
authors.lastname: Stamm
authors.forename: L S
authors.initials: LS
authors.lastname: Peterson
authors.forename: J A
authors.initials: JA
authors.lastname: McGregor
mesh_terms: D000328:Adult; D004716:Endometritis / Q000150:complications* / Q000473:pathology* / Q000601:surgery; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007044:Hysterectomy; D010950:Plasma Cells / Q000473:pathology*; D012189:Retrospective Studies; D014592:Uterine Hemorrhage / Q000150:complications / Q000473:pathology