title: [A case of cervical radiation radiculopathy resembling motor neuron disease].
abstract: A 67-year-old man developed slowly progressive muscular weakness in the bilateral upper extremities (C5- 7 regions) without signs of sensory deficit following the cervical radiation therapy (70.5Gy) for right laryngeal cancer 4 years before. These clinical signs resembled those of lower motor neuron disease. MRI with gadolinium-DTPA, however, showed enhancement in the bilateral C5 and C6 anterior roots, suggesting the cervical radiculopathy due to radiotherapy. It is known that radiation to the spinal cord can lead to "selective anterior horn cell injury". This is the first case report of the cervical radiation radiculopathy, which, if without MRI, might be classified into selective anterior horn cell injury. Suggestion is made for the hypothesis that the spinal motoneuron loss in radiation myelopathy would be caused by retrograde degeneration due to anterior root damages.
authors.affiliation: Department of Neurology, Kyushu University.
authors.forename: Y
authors.initials: Y
authors.lastname: Mitsunaga
authors.forename: T
authors.initials: T
authors.lastname: Yoshimura
authors.forename: H
authors.initials: H
authors.lastname: Hara
authors.forename: T
authors.initials: T
authors.lastname: Yamada
authors.forename: J
authors.initials: J
authors.lastname: Kira
authors.forename: T
authors.initials: T
authors.lastname: Kobayashi
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D019786:Gadolinium DTPA; D006801:Humans; D007822:Laryngeal Neoplasms / Q000532:radiotherapy; D008297:Male; D016472:Motor Neuron Disease; D009333:Neck; D011843:Radiculopathy / Q000175:diagnosis / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects*
chemical_list: D019786:Gadolinium DTPA