title: Lemierre syndrome: a complication of acute pharyngitis.
abstract: Lemierre syndrome, otherwise known as postanginal sepsis or necrobacillosis, is an illness that originates as an acute pharyngitis or tonsillitis which progresses to sepsis, usually fusobacterial, due to suppurative thrombophlebitis of the internal jugular vein. Septic thromboemboli then seed various organs, resulting in multiple organ system pathology, most commonly affecting pulmonary and hepatic systems and joints. Although rare in the age of antibiotics, this disease typically affects previously healthy adolescents with varied clinical manifestations depending upon organ system involvement (A. Lemierre, Lancet March (1936) 701-703; J. Barker, H.T. Winer-Muram, S. Grey, Southern Med. J. 89 (1996) 1021-1023). Prompt diagnosis based on clinical presentation, radiologic findings, particularly CT scanning with contrast and a high index of suspicion, is necessary in order to institute often life saving therapy (J. Barker, H.T. Winer-Muram, S. Grey, Southern Med. J. 89 (1996) 1021-1023). We will present two cases of Lemierre syndrome, review it's clinical presentation, anatomic considerations, particularly it's relationship to the parapharyngeal space, radiographic findings, potential life threatening complications and finally, a unique approach to therapy.
authors.affiliation: Department of Otolaryngology at the State University of New York, Buffalo, USA.
authors.forename: A
authors.initials: A
authors.lastname: Williams
authors.forename: M
authors.initials: M
authors.lastname: Nagy
authors.forename: J
authors.initials: J
authors.lastname: Wingate
authors.forename: L
authors.initials: L
authors.lastname: Bailey
authors.forename: M
authors.initials: M
authors.lastname: Wax
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents; D016470:Bacteremia / Q000175:diagnosis* / Q000628:therapy; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D007601:Jugular Veins; D008171:Lung Diseases / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D009102:Multiple Organ Failure / Q000175:diagnosis / Q000628:therapy; D010612:Pharyngitis / Q000175:diagnosis* / Q000628:therapy; D013290:Streptococcal Infections / Q000175:diagnosis* / Q000628:therapy; D013577:Syndrome; D013927:Thrombosis / Q000175:diagnosis* / Q000628:therapy; D014057:Tomography, X-Ray Computed; D014068:Tonsillectomy; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents