Germinal centers: getting there is half the fun.
Several recent studies have provided new insights into how the infrequent B and T cells that are specific for a particular immunizing antigen come together to form the germinal centers that are crucial to the immune response.
Tarlinton
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The Walter and Eliza Hall Institute for Medical Research PO Royal Melbourne Hospital Victoria, 3050, Australia. tarlinton@wehi.edu.au
D000818:Animals; D000917:Antibody Formation; D000941:Antigens / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D011971:Receptors, Immunologic / Q000276:immunology; D053262:Receptors, OX40; D018124:Receptors, Tumor Necrosis Factor; D013601:T-Lymphocytes / Q000276:immunology*; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000276:immunology
D000941:Antigens; D011971:Receptors, Immunologic; D053262:Receptors, OX40; D018124:Receptors, Tumor Necrosis Factor; C505716:TNFRSF4 protein, human; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7