Comparison of ropivacaine with bupivacaine for paediatric caudal block.
In a double-blind, multicentre study 245 children aged 1-10 yr undergoing elective minor surgery as inpatients were randomly allocated to receive a single caudal extradural injection of 1 ml kg-1 of either 0.25% bupivacaine or 0.2% ropivacaine after induction of light general anaesthesia. The groups were comparable for age, weight, vital signs and duration of surgery. The onset time was similar for ropivacaine and bupivacaine (9.7 vs 10.4 min). Further analgesia was not required in 40% of children. The mean time to first analgesia in the remainder was 233 min in the bupivacaine group and 271 min in the ropivacaine group. No motor block was measurable in either group. Ropivacaine 2 mg kg-1 was as effective as bupivacaine 2.5 mg kg-1 for caudal analgesia in children.
Ivani
G
G
Department of Anaesthesia, Gaslini Children's Hospital, Genoa, Italy.
Lampugnani
E
E
Torre
M
M
Calevo Maria
G
G
DeNegri
P
P
Borrometi
F
F
Messeri
A
A
Calamandrei
M
M
Lonnqvist
P A
PA
Morton
N S
NS
D000577:Amides; D000763:Anesthesia, Caudal / Q000379:methods*; D000768:Anesthesia, General; D000779:Anesthetics, Local; D002045:Bupivacaine; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D006801:Humans; D007223:Infant; D008297:Male; D013511:Minor Surgical Procedures; D000077212:Ropivacaine; D013997:Time Factors
D000577:Amides; D000779:Anesthetics, Local; D000077212:Ropivacaine; D002045:Bupivacaine