[Inhibitory effects of L-ENK on the proliferation of cultured smooth muscle cells of rats].
Using method of MTT and 3H-TdR incorporation, the effect of L-ENK on proliferation and DNA synthesis of the cultured thoracic aortic vascular smooth muscle cells (VSMCs) of SD rats was investigated. The results indicated that L-ENK (10(-5)-10(-4) mol/L) could markedly inhibit proliferation and DNA synthesis of VSMCs, while NAL (10(-8)-10(-5) mol/L) had no such effect, but could antagonize the inhibitory action of L-ENK on the proliferation of VSMCs.
Li
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Y
Department of Pathophysiology, Fourth Military Medical University, Xi'an.
Lin
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SX
Wang
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R
D000818:Animals; D001013:Aorta, Thoracic / Q000166:cytology*; D002455:Cell Division; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D003864:Depression, Chemical; D004743:Enkephalin, Leucine / Q000494:pharmacology*; D009131:Muscle, Smooth, Vascular / Q000166:cytology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D004743:Enkephalin, Leucine; D004247:DNA