title: Use of colchicine to treat severe constipation in developmentally disabled patients.
abstract: BACKGROUND
  Patients with severe developmental disabilities often have concurrent decreased neuromuscular tone of the gastrointestinal tract, which can lead to a weak gag reflex, esophageal reflux, aspiration, and severe intractable constipation. High doses of multiple laxatives are frequently needed to maintain bowel motility in these patients. Colchicine, a natural alkaloid that is primarily used for the treatment of acute attacks of gout, causes an increase in gastrointestinal motility by neurogenic stimulation. The purpose of this study was to determine whether daily colchicine administration can improve bowel function and reduce laxative use in profoundly disabled patients with severe, intractable constipation who currently require large doses of multiple laxatives.
  
  
  METHODS
  Twelve developmentally disabled patients who required three or more different laxatives to manage their chronic constipation were selected to participate in a double-blind, crossover study. Eleven patients who completed the study received placebo treatment for 8 weeks and colchicine treatment for 8 weeks. The total number of bowel movements and the total number of laxatives used during each of the two 8-week periods were compared.
  
  
  RESULTS
  Eight of 11 patients experienced an improved bowel pattern while on colchicine compared with placebo, as defined by an increase in total number of bowel movements or a decrease in total number of rectal laxatives used. No clinically important complications were related to use of colchicine.
  
  
  CONCLUSIONS
  Colchicine appears to be a valuable adjunct in the management of severe intractable constipation. Larger, long-term studies are needed to confirm these preliminary results.
authors.affiliation: Tri-County Family Medicine, Cohocton, NY 14826, USA.
authors.forename: P S
authors.initials: PS
authors.lastname: Frame
authors.forename: P
authors.initials: P
authors.lastname: Dolan
authors.forename: R
authors.initials: R
authors.lastname: Kohli
authors.forename: S W
authors.initials: SW
authors.lastname: Eberly
mesh_terms: D000328:Adult; D002908:Chronic Disease; D003078:Colchicine / Q000627:therapeutic use*; D003248:Constipation / Q000150:complications / Q000188:drug therapy*; D018592:Cross-Over Studies; D002658:Developmental Disabilities / Q000150:complications*; D006233:Persons with Disabilities; D004311:Double-Blind Method; D005260:Female; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D005765:Gastrointestinal Agents; D003078:Colchicine