Sequence characterisation and expression of homeobox HOX A7 in the multi-potential erythroleukaemic cell line TF-1.
Homeobox gene expression was examined in the erythroleukaemic cell line TF-1. Expression of a number of HOX A, B and C genes, including HOX A7 was detected. Expression of this gene has not previously been reported in erythroleukaemic cell lines. A 2.1 kb full length cDNA of the HOX A7 gene was cloned. The predicted amino acid sequence C-terminal to the homeodomain consists of an alanine-rich region and a strongly negatively charged domain consisting entirely of aspartic and glutamic acid residues.
McIlhatton
M A
MA
Department of Haematology, Institute of Clinical Science, The Queen's University of Belfast, Royal Victoria Hospital, Belfast BT12 6BA, UK.
Bremner
P
P
McMullin
M F
MF
Maxwell
A P
AP
Winter
P C
PC
Lappin
T R
TR
D000595:Amino Acid Sequence; D001483:Base Sequence; D018076:DNA, Complementary; D004921:Erythropoietin / Q000494:pharmacology; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D005801:Genes, Homeobox; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology; D018398:Homeodomain Proteins / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics*; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins; D016133:Polymerase Chain Reaction; D014407:Tumor Cells, Cultured
D018076:DNA, Complementary; C115962:HOXA7 protein, human; D018398:Homeodomain Proteins; D009363:Neoplasm Proteins; D004921:Erythropoietin; D016178:Granulocyte-Macrophage Colony-Stimulating Factor