Antimicrobial effect of tetramethyldithiooxamide and its application as a biocide.
Tetramethyldithiooxamide (TMDTOA) is a stable and effective inhibitor of metal corrosion. The antimicrobial effects of TMDTOA and its metal compounds were investigated with regard to their use as biocides for water treatment. Growth of a variety of strains of bacteria and yeasts was completely inhibited at 400 mumol l-1 TMDTOA or its metal complexes. At 100 mg l-1 there was a 99.99% reduction in the number of viable micro-organisms; this activity persisted for 1-3 months. TMDTOA can be produced cheaply at 98% purity by a novel method, representing an alternative cost-effective water treatment agent combining corrosion-inhibiting and biocide characteristics.
Tabakova
S V
SV
Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Kantardjiev
T V
TV
Mircheva
V V
VV
D015169:Colony Count, Microbial; D003343:Corrosion; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000254:growth & development; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D010072:Oxamic Acid / Q000031:analogs & derivatives / Q000494:pharmacology*; D014871:Water Microbiology; D018508:Water Purification; D014881:Water Supply; D015003:Yeasts / Q000187:drug effects* / Q000254:growth & development
D010072:Oxamic Acid