Systemic mastocytosis presenting as profound cardiovascular collapse during anaesthesia.
Mastocytosis is a rare disorder with serious anaesthetic implications. Anaesthetic management is hazardous since trauma, stress, extremes of temperature and drugs may precipitate intra-operative mast cell degranulation. Release of histamine and other mast cell mediators can lead to profound cardiovascular collapse and even death. We present a case report of a patient with mastocytosis who suffered cardiac arrest during anaesthesia. Anaphylactoid/anaphylactic shock may be delayed and lack supporting signs of histamine release such as cutaneous flushing and bronchospasm.
Vaughan
S T
ST
Royal Preston Hospital, Preston, UK.
Jones
G N
GN
D000328:Adult; D000768:Anesthesia, General / Q000009:adverse effects*; D017809:Fatal Outcome; D006323:Heart Arrest / Q000209:etiology*; D006801:Humans; D007431:Intraoperative Complications; D008297:Male; D008415:Mastocytosis / Q000150:complications*