A comparative study of cefixime and chloramphenicol in children with typhoid fever.
We compared cefixime with chloramphenicol in a trial for treatment of children with culture positive typhoid fever. Twenty children were given cefixime 10 mg/kg/day orally for 14 days and twenty received chloramphenicol 50 mg/kg/day orally for 14 days. On entry the clinical characteristics of the two groups were comparable. Clinical cure was observed in 18 (90%) patients treated with cefixime and 9 (45%) treated with chloramphenicol. Of 11 patients who did not respond to chloramphenicol, 10 were switched over to cefixime and all were cured. Overall 28 out of 30 cases (93.3%) were cured by cefixime.
Rabbani
M W
MW
Department of Paediatrics, Nishtar Medical College, Multan.
Iqbal
I
I
Malik
M S
MS
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D020682:Cefixime; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002511:Cephalosporins / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002701:Chloramphenicol / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D012074:Remission Induction; D012449:Safety; D013997:Time Factors; D014435:Typhoid Fever / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D002701:Chloramphenicol; D020682:Cefixime; D002439:Cefotaxime