A study of HLA-DPB1 phenotypes reveals DPB1*6301 in a rural population from Cameroon.
Several recently reported HLA-DPB1 alleles have only been identified in a single family or individuals and are of unknown distribution world-wide. Many new DPB1 alleles appear to arise as a result of gene conversion-like events, which may localize variant DPB1 alleles to the population in which they were first identified. Using two SSOP-based typing methods in parallel, we have identified HLA-DPB1*6301 in an individual from rural Cameroon which has previously only been reported in a family of Mexican-American origin. The presence of DPB1*6301 was confirmed by sequence-based typing of exon 2.
Poulton
K V
KV
ARC Epidemiology Research Unit, Manchester University, UK.
Kennedy
L J
LJ
Ross
J
J
Thomson
W
W
Mbanya
J C
JC
Ollier
W E
WE
D000483:Alleles; D002163:Cameroon; D006682:HLA-DP Antigens / Q000235:genetics*; D059868:HLA-DP beta-Chains; D006801:Humans; D010641:Phenotype; D016133:Polymerase Chain Reaction / Q000379:methods; D012424:Rural Population
D006682:HLA-DP Antigens; D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen