[Glucocorticoid (prednisolone) effects on various blood, urine and liver parameters in cows in the second post partum week].
Starting on the 7th day post partum, 200 mg prednisolone were given daily to four healthy cows over a period of five days in order to examine how fat metabolism and liver function were influenced. Samples of blood and urine were taken daily as well as liver biopsies on the third and fifth day. These findings in the cows of the experimental group were compared to those in the four untreated cows (control group). Prednisolone induced a significant increase in glucose and insulin serum concentrations and a decrease of FFA and bilirubin concentrations as well as lipid and rising glycogen concentrations in the liver. The ASAT and GLDH activities as well as the thyroxin concentration decreased tendentiously. The cortisol concentration decreased shortly insignificantly. Acid base status, calcium as well as anorganic phosphorus concentrations were not noticeably influenced. Signs of a higher risk of infection were not observed. The results show that the effect of prednisolone is indirect antilipolytic and protects the liver. They therefore do not support the idea that glucocorticoids lead to an increased lipolysis and fat accumulation in the liver of cows.
Fürll
M
M
Medizinischen Tierklinik, Veterinärmedizinischen Fakultät der Universität Leipzig.
Fürll
B
B
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000818:Animals; D001663:Bilirubin / Q000097:blood; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D001798:Blood Proteins / Q000378:metabolism; D002417:Cattle; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology*; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000097:blood*; D008099:Liver / Q000187:drug effects / Q000502:physiology*; D008111:Liver Function Tests; D008112:Liver Glycogen / Q000378:metabolism; D049590:Postpartum Period / Q000097:blood / Q000378:metabolism* / Q000652:urine; D011239:Prednisolone / Q000494:pharmacology*; D011507:Proteinuria; D012016:Reference Values; D013997:Time Factors
D001786:Blood Glucose; D001798:Blood Proteins; D005230:Fatty Acids, Nonesterified; D005938:Glucocorticoids; D007328:Insulin; D008112:Liver Glycogen; D011239:Prednisolone; D001663:Bilirubin; D006854:Hydrocortisone