Replication conrol: choreographing replication origins.
Budding yeast replication origins are activated during S phase according to a predetermined temporal programme. Two recent studies indicate that this programme is executed, at least in part, by the S-phase-promoting cyclins that act to assemble a pre-initiation complex which includes the Cdc45 protein.
Diffley
J F
JF
ICRF Clare Hall Laboratories South Mimms, Hertfordshire, EN6 3LD, UK. J.Diffley@icrf.icnet.uk
D002352:Carrier Proteins / Q000378:metabolism; D016213:Cyclins / Q000502:physiology; D004261:DNA Replication; D004268:DNA-Binding Proteins; D005656:Fungal Proteins / Q000378:metabolism; D008957:Models, Genetic; D009687:Nuclear Proteins / Q000378:metabolism; D018741:Replication Origin; D016196:S Phase; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000235:genetics* / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins
C102209:CDC45 protein, S cerevisiae; D002352:Carrier Proteins; D016213:Cyclins; D004268:DNA-Binding Proteins; D005656:Fungal Proteins; D009687:Nuclear Proteins; D029701:Saccharomyces cerevisiae Proteins