title: Prognostic value of JC virus load in cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy.
abstract: JC virus (JCV) load was determined by using quantitative polymerase chain reaction in cerebrospinal fluid (CSF) of 12 patients with AIDS-associated progressive multifocal leukoencephalopathy (PML) and compared with clinical outcome. JCV loads varied widely (3-7 log10 JCV equivalents/mL of CSF) and were apparently not related to absolute CD4 cell counts or CSF and plasma human immunodeficiency virus type 1 loads. A significant correlation was observed between JCV load and survival time (Spearman's rank correlation, -0.83; P<. 01). Moreover, CSF JCV load decreased and then became undetectable in 1 PML patient receiving cidofovir treatment, and this was associated with clinical improvement. These results show that CSF JCV load may be useful as a prognostic parameter and in monitoring the effectiveness of anti-JCV therapies in PML patients.
authors.affiliation: Department of Microbiology, Paul Brousse Hosptial, Cedex, France. yassine.taoufik@pbr.ap-hop-paris.fr
authors.forename: Y
authors.initials: Y
authors.lastname: Taoufik
authors.forename: J
authors.initials: J
authors.lastname: Gasnault
authors.forename: A
authors.initials: A
authors.lastname: Karaterki
authors.forename: M
authors.initials: M
authors.lastname: Pierre Ferey
authors.forename: E
authors.initials: E
authors.lastname: Marchadier
authors.forename: C
authors.initials: C
authors.lastname: Goujard
authors.forename: A
authors.initials: A
authors.lastname: Lannuzel
authors.forename: J F
authors.initials: JF
authors.lastname: Delfraissy
authors.forename: E
authors.initials: E
authors.lastname: Dussaix
mesh_terms: D015526:AIDS Dementia Complex / Q000134:cerebrospinal fluid* / Q000503:physiopathology / Q000821:virology*; D017088:AIDS-Related Opportunistic Infections / Q000134:cerebrospinal fluid / Q000188:drug therapy; D000998:Antiviral Agents / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D000077404:Cidofovir; D003596:Cytosine / Q000031:analogs & derivatives / Q000627:therapeutic use; D017931:DNA Primers; D015342:DNA Probes; D004279:DNA, Viral / Q000134:cerebrospinal fluid; D005260:Female; D015497:HIV-1 / Q000254:growth & development / Q000302:isolation & purification*; D006801:Humans; D007577:JC Virus / Q000302:isolation & purification*; D008297:Male; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000627:therapeutic use; D030361:Papillomavirus Infections / Q000134:cerebrospinal fluid* / Q000188:drug therapy / Q000209:etiology; D016133:Polymerase Chain Reaction; D011237:Predictive Value of Tests; D011379:Prognosis; D018709:Statistics, Nonparametric; D014412:Tumor Virus Infections / Q000134:cerebrospinal fluid* / Q000188:drug therapy / Q000209:etiology; D019562:Viral Load
chemical_list: D000998:Antiviral Agents; D017931:DNA Primers; D015342:DNA Probes; D004279:DNA, Viral; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D003596:Cytosine; D000077404:Cidofovir