Linking extracellular survival signals and the apoptotic machinery.
The survival of cells in multicellular organisms requires continuous stimulation from the extracellular environment. The phosphatidylinositol-3' kinase/Akt signaling cascade has been identified as a critical pathway for the transduction of extracellular survival signals. The finding that the pro-apoptotic protein BAD is a substrate of Akt/PKB has provided the first link between extracellular survival signals and the apoptotic machinery.
Nuñez
G
G
Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor 48109, USA. Gabriel.Nunez@umich.edu
del Peso
L
L
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002470:Cell Survival / Q000502:physiology; D005057:Eukaryotic Cells / Q000166:cytology* / Q000378:metabolism; D005110:Extracellular Space / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*