Brugada syndrome associated with an autonomic disorder.
A 44 year old man with Brugada syndrome and ventricular fibrillation had an autonomic disorder, shown by spectral analysis of heart rate variability and 123I-MIBG myocardial scintigraphy. Periodic variation of the ST segments was detected by Holter ECG. Increased high frequency power (0.15-0.40 Hz), an index of parasympathetic nerve activity, was observed just before ST segment elevation. In addition, local dysfunction of sympathetic nerves in the left ventricle was detected by 123I-MIBG myocardial scintigraphy. Unbalanced autonomic nerve function plays an important role in inducing Brugada-type ECG signs.
Nomura
M
M
Second Department of Internal Medicine, School of Medicine, University of Tokushima, Japan.
Nada
T
T
Endo
J
J
Kondo
Y
Y
Yukinaka
M
M
Saito
K
K
Ito
S
S
Mori
H
H
Nakaya
Y
Y
Shinomiya
H
H
D000328:Adult; D001341:Autonomic Nervous System / Q000503:physiopathology*; D001342:Autonomic Nervous System Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002037:Bundle-Branch Block / Q000000981:diagnostic imaging / Q000503:physiopathology*; D015716:Electrocardiography, Ambulatory; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012815:Signal Processing, Computer-Assisted; D013577:Syndrome; D014693:Ventricular Fibrillation / Q000000981:diagnostic imaging / Q000503:physiopathology*
D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals