Cajal-Retzius cells, Reelin, and the formation of layers.
Early-generated Cajal-Retzius cells in the marginal zone of the cortex synthesize and secrete the glycoprotein Reelin. The reelin gene is deleted in reeler mice, which show characteristic alterations in cortical lamination. Recent studies have shed some light on the role of Cajal-Retzius cells and Reelin in the formation of cell and fiber layers in the neocortex and hippocampus.
Frotscher
M
M
Institute of Anatomy, University of Freiburg, Germany. frotsch@uni-freiburg.de
D000818:Animals; D015816:Cell Adhesion Molecules, Neuronal / Q000502:physiology*; D016326:Extracellular Matrix Proteins / Q000502:physiology*; D006624:Hippocampus / Q000166:cytology*; D051379:Mice; D008818:Mice, Neurologic Mutants; D019579:Neocortex / Q000166:cytology*; D009419:Nerve Tissue Proteins / Q000502:physiology; D009474:Neurons / Q000737:chemistry / Q000166:cytology / Q000502:physiology*; D000091042:Reelin Protein; D012697:Serine Endopeptidases
D015816:Cell Adhesion Molecules, Neuronal; D016326:Extracellular Matrix Proteins; D009419:Nerve Tissue Proteins; D000091042:Reelin Protein; C000717128:Reln protein, mouse; D012697:Serine Endopeptidases