Genetic characterization of pepP, which encodes an aminopeptidase P whose deficiency does not affect Lactococcus lactis growth in milk, unlike deficiency of the X-prolyl dipeptidyl aminopeptidase.
We sequenced the pepP gene of Lactococcus lactis, which encodes an aminopeptidase P (PepP), and demonstrated that the X-prolyl dipeptidyl aminopeptidase PepX plays a more important role than PepP in nitrogen nutrition. PepP shares homology with methionine aminopeptidases and could play a role in the maturation of nascent proteins.
Matos
J
J
Unité de Recherches de Biochimie et Structure des Protéines, I.N.R. A., 78352 Jouy en Josas Cedex, France.
Nardi
M
M
Kumura
H
H
Monnet
V
V
D000595:Amino Acid Sequence; D000626:Aminopeptidases / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D002874:Chromosome Mapping; D002876:Chromosomes, Bacterial; D017124:Conserved Sequence; D005798:Genes, Bacterial; D013294:Lactococcus lactis / Q000201:enzymology* / Q000235:genetics* / Q000254:growth & development; D063208:Methionyl Aminopeptidases; D008892:Milk / Q000382:microbiology*; D008969:Molecular Sequence Data; D005810:Multigene Family; D010641:Phenotype; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
D000626:Aminopeptidases; D063208:Methionyl Aminopeptidases; C022750:X-Pro aminopeptidase