Test type influences the expression of lithium chloride-induced hyperalgesia.
The hyperalgesic properties of the emetic drug lithium chloride (LiCl) were examined in eight experiments. At a dose of 63.6 mg/kg, LiCl produced hyperalgesia in the radiant-heat (Experiment la) and immersion (Experiment 1b) tail-flick tests. At doses of 15.9, 31.8, 63.6, and 127.2 mg/kg, LiCl failed to produce hyperalgesia during the delayed behavioral response in the formalin test (Experiments 2a and 2b), but 63.6 mg/kg LiCl did produce hyperalgesia during the normally quiescent, interphase period of formalin responding (Experiment 2c). At the dose of 63.6 mg/kg, LiCl did not produce hyperalgesia in the hotplate test (Experiments 3a and 3b) and did not exert significant motoric effects in a step-down passive-avoidance task (Experiment 4). The results were discussed with reference to the behavioral effects of LiCl and their implications for demonstrations of associatively mediated morphine analgesic tolerance.
McNally
G P
GP
School of Psychology, University of New South Wales, Sydney, Australia.
Westbrook
R F
RF
D000818:Animals; D018692:Antimanic Agents / Q000633:toxicity*; D001362:Avoidance Learning / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006358:Hot Temperature; D006930:Hyperalgesia / Q000139:chemically induced*; D007101:Immersion; D018021:Lithium Chloride / Q000633:toxicity*; D008297:Male; D010147:Pain Measurement; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects
D018692:Antimanic Agents; D018021:Lithium Chloride