Human genes for KNSL4 and MAZ are located close to one another on chromosome 16p11.2.
KNSL4 (Kid; kinesin-like DNA-binding protein) is a member of the kinesin family that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Myc-associated zinc finger protein (MAZ) participates in both the initiation and the termination of transcription of target genes. We isolated genomic DNA clones that encoded KNSL4 and MAZ from a human cosmid library. Sequence analysis revealed that the two genes were very close to one another. The distance between the two genes was only 1. 2 kb, and this intervening 1.2-kb region was extremely GC-rich. The gene for KNSL4 spanned 16 kb and consisted of 14 exons and 13 introns, while the gene for MAZ spanned 6 kb and consisted of 5 exons and 4 introns. The two genes were mapped to chromosome 16p11.2 by fluorescence in situ hybridization.
Song
J
J
RIKEN, 3-1-1 Koyadai, Tsukuba, Ibaraki, 305-0074, Japan.
Murakami
H
H
Yang
Z Q
ZQ
Koga
C
C
Adati
N
N
Murata
T
T
Geltinger
C
C
Saito-Ohara
F
F
Ikeuchi
T
T
Matsumura
M
M
Itakura
K
K
Kanazawa
I
I
Sun
K
K
Yokoyama
K K
KK
D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics*; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D016547:Kinesins / Q000235:genetics*; D008969:Molecular Sequence Data; D012326:RNA Splicing / Q000235:genetics; D015183:Restriction Mapping; D017422:Sequence Analysis, DNA; D014157:Transcription Factors / Q000235:genetics*; D016335:Zinc Fingers / Q000235:genetics
D004268:DNA-Binding Proteins; C098764:KIF22 protein, human; D014157:Transcription Factors; C076035:c-MYC-associated zinc finger protein; D016547:Kinesins