Agreement between predicted risk and prevalence of Down syndrome in second-trimester triple-marker screening in Japan.
Based on 9350 pregnant Japanese women who were screened by serum triple-marker determination, accuracy of predicted risk for Down syndrome was examined using 24 Down syndrome cases detected either prenatally or postnatally. The correlation is statistically very high (r = 0.98) between the predicted risks and the prevalence of Down syndrome cases. Here we emphasize that this could be accomplished only by an extensive follow-up study, implemented in our prospective intervention programme.
Onda
T
T
Jikei University School of Medicine, Tokyo, Japan.
Tanaka
T
T
Takeda
O
O
Kitagawa
M
M
Kuwabara
Y
Y
Yamamoto
H
H
Iinuma
K
K
Shimomura
K
K
D000649:Amniocentesis; D015415:Biomarkers / Q000097:blood*; D004314:Down Syndrome / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007564:Japan / Q000453:epidemiology; D007621:Karyotyping; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012016:Reference Values; D012307:Risk Factors; D012680:Sensitivity and Specificity
D015415:Biomarkers