Interactions between T lymphocytes and endothelial cells in allograft rejection.
Vascular endothelial cells participate in the process of allograft rejection by promoting both the recruitment and the activation of alloreactive T cells. There have been three major recent advances in the field of interactions between T cells and endothelial cells that are of direct relevance to the process of cell-mediated responses to allografts: first, endothelial cells mediate selective recruitment of CD4+ T cell subsets, including naive and memory T cells and T cell subsets of the Th1 and Th2 phenotypes; second, endothelial cells co-stimulate the production of effector cytokines by helper T cells; and third, endothelial cells regulate T cell apoptosis.
Briscoe
D M
DM
The Division of Nephrology, Children's Hospital, Boston, MA 02115, USA. briscoe@a1.tch.harvard.edu
Alexander
S I
SI
Lichtman
A H
AH
D000818:Animals; D017209:Apoptosis; D019013:CD40 Antigens / Q000502:physiology; D023201:CD40 Ligand; D002450:Cell Communication; D016207:Cytokines / Q000096:biosynthesis; D004730:Endothelium, Vascular / Q000166:cytology* / Q000502:physiology; D006084:Graft Rejection; D006801:Humans; D008562:Membrane Glycoproteins / Q000502:physiology; D013601:T-Lymphocytes / Q000502:physiology*; D014184:Transplantation, Homologous / Q000276:immunology
D019013:CD40 Antigens; D016207:Cytokines; D008562:Membrane Glycoproteins; D023201:CD40 Ligand