No association between dopamine D1, D2, and D3 receptor genes and manic-depressive illness.
BACKGROUND
The dopaminergic receptor genes are candidate genes for manic-depressive illness (MDI). To test this putative involvement we used a case-control study on samples from the native population of the northwest part of France.


METHODS
Fifty patients for D1 and D2, 61 patients for D3, and 86-223 controls were tested.


RESULTS
No significant association was found between allelic frequencies or genotype counts and MDI, even when the data were pooled with those from published studies.


CONCLUSIONS
Single mutations of either of the studied receptor genes are not major determinants of MDI.
Savoye
C
C
Service de Pédopsychiatrie, C.H.R.U. Clémenceau, Caen, France.
Laurent
C
C
Amadeo
S
S
Gheysen
F
F
Leboyer
M
M
Lejeune
J
J
Zarifian
E
E
Mallet
J
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001714:Bipolar Disorder / Q000235:genetics* / Q000523:psychology; D015139:Blotting, Southern; D005260:Female; D005602:France; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D017447:Receptors, Dopamine D1 / Q000235:genetics*; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D050637:Receptors, Dopamine D3
C493593:DRD3 protein, human; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3