title: Rapid response of emotional incontinence to selective serotonin reuptake inhibitors.
abstract: Emotional incontinence (EI) is a perturbing condition characterized by uncontrollable outbursts of exaggerated, involuntary facial expressions and pathological crying or laughter. There is increasing evidence that serotonergic neurotransmission may be damaged in EI. The authors report 4 pathological crying cases (3 poststroke and 1 with multiple sclerosis) and 1 case of pathological laughter after traumatic brain injury. EI improved dramatically with three different selective serotonin reuptake inhibitors (fluoxetine, sertraline, and paroxetine) in the context of these different CNS diseases.
authors.affiliation: Medical University of South Carolina, Department of Psychiatry, Charleston, SC 29403, USA.
authors.forename: Z
authors.initials: Z
authors.lastname: Nahas
authors.forename: K A
authors.initials: KA
authors.lastname: Arlinghaus
authors.forename: K J
authors.initials: KJ
authors.lastname: Kotrla
authors.forename: R R
authors.initials: RR
authors.lastname: Clearman
authors.forename: M S
authors.initials: MS
authors.lastname: George
mesh_terms: D000328:Adult; D000342:Affective Symptoms / Q000188:drug therapy* / Q000523:psychology; D000368:Aged; D001930:Brain Injuries / Q000150:complications / Q000523:psychology; D002561:Cerebrovascular Disorders / Q000150:complications / Q000523:psychology; D003448:Crying; D005473:Fluoxetine / Q000627:therapeutic use; D006801:Humans; D007845:Laughter; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000523:psychology; D017374:Paroxetine / Q000627:therapeutic use; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D020280:Sertraline / Q000627:therapeutic use
chemical_list: D005473:Fluoxetine; D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline