title: Glomerulosclerosis in the remnant kidney rat is modulated by dietary alpha-tocopherol.
abstract: Glomerulosclerosis and tubulointerstitial injury are characteristic features seen in the subtotal (5/6) nephrectomy remnant kidney model in the rat. Oxidative stress from renal mass reduction contributes to the glomerular and tubular injury. Previous studies have clearly demonstrated the prevention or inhibition of such injury by an antioxidant such as alpha-tocopherol. However, few data are available on the ability of alpha-tocopherol to modulate or arrest progression of the established disease. This study examines whether alpha-tocopherol modulates glomerulosclerosis and tubulointerstitial injury when it is given 2 wk after renal damage has been established. The findings indicate that alpha-tocopherol has the capacity to modulate both tubulointerstitial injury and glomerulosclerosis, lower the elevated expression of transforming growth factor-beta1, and reduce plasma and kidney malondialdehyde concentration, the end product of lipid peroxidation. The results support the potential utility of alpha-tocopherol in reversing established glomerulosclerosis and tubulointerstitial injury in a remnant kidney model.
authors.affiliation: Department of Pediatrics, Virginia Commonwealth University's Medical College of Virginia Campus, Richmond, USA.
authors.forename: S
authors.initials: S
authors.lastname: Hahn
authors.forename: N B
authors.initials: NB
authors.lastname: Kuemmerle
authors.forename: W
authors.initials: W
authors.lastname: Chan
authors.forename: S
authors.initials: S
authors.lastname: Hisano
authors.forename: P
authors.initials: P
authors.lastname: Saborio
authors.forename: R J
authors.initials: RJ
authors.lastname: Krieg
authors.forename: J C
authors.initials: JC
authors.lastname: Chan
mesh_terms: D000818:Animals; D003404:Creatinine / Q000097:blood; D004032:Diet; D005923:Glomerulosclerosis, Focal Segmental / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology*; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism; D009392:Nephrectomy; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D016212:Transforming Growth Factor beta / Q000235:genetics; D014810:Vitamin E / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use
chemical_list: D012333:RNA, Messenger; D016212:Transforming Growth Factor beta; D014810:Vitamin E; D008315:Malondialdehyde; D003404:Creatinine