title: CD4 dimerization and oligomerization: implications for T-cell function and structure-based drug design.
abstract: Recent studies of CD4 structure and function have revealed possible mechanisms for CD4 self-association, with implications for its role in T-cell activation. Here, the authors discuss the formulation of a hypothetical three-dimensional model of CD4 oligomerization and how it impacts on the understanding of T-cell function and rational drug design targeting specific CD4 surface functional sites.
authors.affiliation: Kimmel Cancer Institute, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.
authors.forename: S
authors.initials: S
authors.lastname: Li
authors.forename: T
authors.initials: T
authors.lastname: Satoh
authors.forename: R
authors.initials: R
authors.lastname: Korngold
authors.forename: Z
authors.initials: Z
authors.lastname: Huang
mesh_terms: D015704:CD4 Antigens / Q000737:chemistry* / Q000276:immunology; D019281:Dimerization; D015195:Drug Design; D006801:Humans; D008213:Lymphocyte Activation; D008285:Major Histocompatibility Complex / Q000276:immunology; D008956:Models, Chemical; D018448:Models, Immunological; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology*
chemical_list: D015704:CD4 Antigens; D011948:Receptors, Antigen, T-Cell