2-Amino-2-oxazolines, Part 9: Synthesis and pharmacological evaluation of N-phenyl-N'-[1-[3-(1-aryl-4-piperazinyl)propan-2-ol]]ureas.
N-Phenyl-N'-[1-[3-(1-aryl-4-piperazinyl)propan-2-ol]]ureas (3) were synthesized from the 3-phenylcarbamoyl-5-[(1-aryl-4-piperazinyl)methyl]-2-iminooxazolidine s (1) via the corresponding 2-oxazolidinones (2). The prepared compounds were screened for their antiallergic and analgesic activities.
Bosc
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Laboratoire de Chimie Physique, UFR des Sciences Pharmaceutiques, Université Victor Segalen Bordeaux, France.
Jarry
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D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D018926:Anti-Allergic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006168:Guinea Pigs; D006633:Histamine Antagonists / Q000494:pharmacology; D010147:Pain Measurement / Q000187:drug effects; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D014508:Urea / Q000138:chemical synthesis* / Q000494:pharmacology
D000700:Analgesics; D018926:Anti-Allergic Agents; D006633:Histamine Antagonists; D014508:Urea