Imprinting of hippocampal metabolism of choline by its availability during gestation: implications for cholinergic neurotransmission.
Choline supplementation during the second half of the gestational period in rats permanently improves visuospatial memory. Choline availability during this period also alters the turnover of choline and acetylcholine in the hippocampus in 3-4 week-old animals in a complex pattern consistent with the notion that cholinergic neurotransmission is enhanced by prenatal choline supplementation.
Blusztajn
J K
JK
Department of Pathology, Boston University School of Medicine, MA 02118, USA.
Cermak
J M
JM
Holler
T
T
Jackson
D A
DA
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D002794:Choline / Q000378:metabolism*; D005260:Female; D018392:Genomic Imprinting; D005865:Gestational Age; D006624:Hippocampus / Q000378:metabolism*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D009435:Synaptic Transmission / Q000502:physiology*
D002794:Choline; D000109:Acetylcholine