title: Alloimmunization against human platelet antigen 2 (HPA2) in a series of multi-transfused beta-thalassemia patients.
abstract: In our study we investigated the presence of anti-human platelet antigen (HPA) alloantibodies in a series of 10 beta-thalassemia major patients submitted for more than 10 years to periodic blood transfusions (every 2-3 weeks). We found that 2 out of the 10 patients developed anti-HPA2a + HPA1b and anti-HPA2b antibodies. Our results highlight that HPA alloimmunization in multitransfused patients is a real possibility.
authors.forename: P L
authors.initials: PL
authors.lastname: Tazzari
authors.forename: F
authors.initials: F
authors.lastname: Ricci
authors.forename: C
authors.initials: C
authors.lastname: Tassi
authors.forename: A
authors.initials: A
authors.lastname: Bontadini
authors.forename: F
authors.initials: F
authors.lastname: Fruet
authors.forename: R
authors.initials: R
authors.lastname: Conte
mesh_terms: D000328:Adult; D016824:Antigens, Human Platelet / Q000276:immunology*; D005260:Female; D005334:Fever / Q000209:etiology; D006801:Humans; D007114:Immunization; D007518:Isoantibodies / Q000096:biosynthesis* / Q000276:immunology; D008297:Male; D012768:Shivering; D065227:Transfusion Reaction; D017086:beta-Thalassemia / Q000276:immunology / Q000628:therapy*
chemical_list: C115212:2a alloantigen, human; C071221:2b alloantigen, human; D016824:Antigens, Human Platelet; D007518:Isoantibodies