Germinated barley foodstuff improves constipation induced by loperamide in rats.
The effects of germinated barley foodstuff (GBF) derived from the aleurone and scutellum fractions of germinated barley low-lignified hemicellulose were examined in Sprague-Dawley rats with constipation induced by loperamide by addition to the diet (2 mg/kg body weight). Bowel movements were higher in the GBF-fed rats than in the cellulose-fed rats used as a control. Fecal water content was also higher in the GBF-fed rats. The concentration of short chain fatty acids in cecal content, especially butyrate, was significantly higher in the GBF-fed rats than in the cellulose-fed rats. These findings suggested that GBF helps normalize defecation not only in diarrhea but also constipation.
Kanauchi
O
O
Applied Bioresearch Center, Corporate Research and Development Division Kirin Brewery Co. Ltd., Gunma, Japan.
Hitomi
Y
Y
Agata
K
K
Nakamura
T
T
Fushiki
T
T
D000818:Animals; D001467:Hordeum / Q000378:metabolism*; D008139:Loperamide / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D008139:Loperamide