[Changes in reactivity of the middle cerebral artery caused by cerebral circulation disturbances of ischemic and hemorrhagic types in rats].
Reactivity of the middle cerebral artery (MCA) to serotonin was attenuated in vitro in vessels taken from rats following an audiogenic stress. The MCA reactivity to endothelin remained unchanged. Chronic cerebral ischemia diminished the 5-HT-induced contraction and the contractile responses to endothelin were enhanced. Preliminary hypoxic adaptation decreased the artery sensitivity to endothelin in ischemic animals. The findings suggest that a progressing ischemia may involve changes in reactivity of cerebral vessels whereupon hypoxic adaptation may prove to be protecting the brain from ischemia development.
Fadiukova
O E
OE
Moscow State University, Vorobyevy Gory, Russia.
Storozhevykh
T P
TP
Pinelis
V G
VG
Koshelev
V B
VB
D000222:Adaptation, Physiological; D000818:Animals; D002536:Cerebral Arteries / Q000503:physiopathology*; D002543:Cerebral Hemorrhage / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D016232:Endothelins / Q000494:pharmacology; D005260:Female; D000860:Hypoxia / Q000503:physiopathology; D002546:Ischemic Attack, Transient / Q000503:physiopathology*; D051381:Rats; D012701:Serotonin / Q000494:pharmacology; D014661:Vasoconstriction / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000494:pharmacology
D016232:Endothelins; D014662:Vasoconstrictor Agents; D012701:Serotonin