title: Human leucocytic antigens (HLA) in breast cancer.
abstract: HLA frequencies of fifty (50) female breast cancer patients were compared with 200 age matched female controls. A total of 20 HLA-A locus, 35 HLA-B locus and 8 HLA-C locus antigens were studied. The HLA-A2, A11, Aw19 and A30; HLA-B8, B14 and HLA Cw6 were found significantly higher than the controls. The HLA-A11, HLA-Aw19 and HLA-B8 were found protective whereas, HLA-A2, HLA-B14 and HLA-Cw6 were a risk for breast cancer. The prective antigens' probable involvement through immunogenic mechanism in breast cancer is emphasized in this article.
authors.affiliation: Radiotherapy Dept, All India Institute of Medical Sciences, Ansari Nagar, New Delhi.
authors.forename: B M
authors.initials: BM
authors.lastname: Biswal
authors.forename: R
authors.initials: R
authors.lastname: Kumar
authors.forename: P K
authors.initials: PK
authors.lastname: Julka
authors.forename: U
authors.initials: U
authors.lastname: Sharma
authors.forename: M C
authors.initials: MC
authors.lastname: Vaidya
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D015234:HLA-A Antigens / Q000032:analysis; D015235:HLA-B Antigens / Q000032:analysis; D015236:HLA-C Antigens / Q000032:analysis; D006801:Humans; D008875:Middle Aged
chemical_list: D014408:Biomarkers, Tumor; D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens