title: [The role of high-dose chemotherapy with hemopoietic stem cell transplantation in the treatment of breast cancer with unfavorable prognosis].
abstract: High-dose chemotherapy using transplantation of hemopoietic precursor cells offers much advantage for treatment of prognostically unfavorable cancers of the breast. Both experimental and clinical evidence points to a potential of raising antitumor effect by increased dosage of chemical drugs. Clinical studies using high-dose chemotherapy for treating patients with stage II-III tumors or with greater than or equal to 10 positive axillary lymph nodes, and locally-advanced and disseminated tumor established a relative rise in overall and recurrence-free survival, as compared with standard treatment. Hazardous cytopenia and related complications can be significantly reduced when hemopoietic precursor cells are transplanted from peripheral blood.
authors.affiliation: N.N. Blokhin Center for Cancer Research, Russian Academy of Medical Sciences, Moscow.
authors.forename: V V
authors.initials: VV
authors.lastname: Ptushkin
authors.forename: K P
authors.initials: KP
authors.lastname: Laktionov
authors.forename: S M
authors.initials: SM
authors.lastname: Portnoĭ
authors.forename: V B
authors.initials: VB
authors.lastname: Larionova
authors.forename: N V
authors.initials: NV
authors.lastname: Zhukov
authors.forename: D M
authors.initials: DM
authors.lastname: Mkheidze
authors.forename: K L
authors.initials: KL
authors.lastname: Chimishkian
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000009:adverse effects; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D018572:Disease-Free Survival; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D009367:Neoplasm Staging; D011379:Prognosis; D016019:Survival Analysis; D016896:Treatment Outcome