title: The bactericidal activity of clarithromycin versus ampicillin alone and in combination with omeprazole and/or bismuth against clarithromycin-susceptible and clarithromycin-resistant strains of Helicobacter pylori.
abstract: We evaluated the in vitro bactericidal effect of clarithromycin versus ampicillin alone and in combination against clarithromycin-sensitive and clarithromycin-resistant strains of Helicobacter pylori. No combination containing clarithromycin achieved complete bactericidal effect against clarithromycin-resistant strains. Complete bactericidal effect was achieved for all strains by triple-agent combinations that contained bismuth, omeprazole, and relatively high concentrations of ampicillin. These in vitro results demonstrate the additive bactericidal activity provided by a combination of agents for the eradication of H. pylori. Bismuth may play a particularly important role in the bactericidal effect.
authors.affiliation: Pathology and Laboratory Medicine Service/113, McGuire Veterans Affairs Medical Center, Richmond, Virginia 23249-0001, USA.
authors.forename: P E
authors.initials: PE
authors.lastname: Coudron
authors.forename: C W
authors.initials: CW
authors.lastname: Stratton
mesh_terms: D000667:Ampicillin / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001729:Bismuth / Q000494:pharmacology*; D017291:Clarithromycin / Q000494:pharmacology*; D004347:Drug Interactions; D004352:Drug Resistance, Microbial; D016480:Helicobacter pylori / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D008826:Microbial Sensitivity Tests; D009853:Omeprazole / Q000494:pharmacology*; D011706:Pyloric Antrum / Q000382:microbiology*; D012680:Sensitivity and Specificity; D013045:Species Specificity
chemical_list: D000900:Anti-Bacterial Agents; D000667:Ampicillin; D017291:Clarithromycin; D009853:Omeprazole; D001729:Bismuth