Angiogenesis in P- and E-selectin-deficient mice.
OBJECTIVE
Several observations reported earlier indicated that the selectins, in particular E-selectin, might be involved in angiogenesis; however, mice deficient in the endothelial selectins develop normally. To clarify the role of endothelial selectins in angiogenesis, we have studied experimentally induced angiogenesis in selectin-deficient mice.


METHODS
Hydron pellets containing either basic fibroblast growth factor or the inflammatory cytokine tumor necrosis factor alpha were implanted into the corneas of wild-type and P- and/or E-selectin-deficient mice.


RESULTS
The lengths and circumferential range of the newly formed blood vessels in the corneas of the endothelial selectin-deficient mice were similar to those of wild-type mice.


CONCLUSIONS
The endothelial selectins are not essential in experimentally induced angiogenesis in vivo.
Hartwell
D W
DW
Center for Blood Research, Harvard Medical School, Boston, MA 02115, USA.
Butterfield
C E
CE
Frenette
P S
PS
Kenyon
B M
BM
Hynes
R O
RO
Folkman
J
J
Wagner
D D
DD
D000818:Animals; D003315:Cornea / Q000098:blood supply / Q000187:drug effects; D019040:E-Selectin / Q000235:genetics / Q000502:physiology*; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D018919:Neovascularization, Physiologic / Q000187:drug effects; D019007:P-Selectin / Q000235:genetics / Q000502:physiology*; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000008:administration & dosage / Q000494:pharmacology
D019040:E-Selectin; D019007:P-Selectin; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D016222:Fibroblast Growth Factor 2