Neurological complications of radiotherapy and chemotherapy.
Neurological complications of radiotherapy and chemotherapy can affect the central or peripheral nervous system. Most are dose-dependent and constitute a limiting factor in the administration of treatments. Radiation-induced neurological complications are classified as acute, early-delayed or delayed. The most important are radionecrosis and cognitive dysfunction/leukoencephalopathy. Neurotoxicity of chemotherapy is frequent and depends upon dose, type of drugs (especially cisplatin and methotrexate) and their combination with radiotherapy.
Keime-Guibert
F
F
Service de Neurologie, Hôpital de la Salpetrière, Paris, France.
Napolitano
M
M
Delattre
J Y
JY
D000970:Antineoplastic Agents / Q000009:adverse effects*; D003071:Cognition / Q000187:drug effects; D016371:Cranial Irradiation / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D009422:Nervous System Diseases / Q000209:etiology* / Q000473:pathology; D011878:Radiotherapy / Q000009:adverse effects*; D013116:Spinal Cord / Q000528:radiation effects
D000970:Antineoplastic Agents