title: Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6.
abstract: We report here the identification of two distinct human cDNAs, called VNN1 and VNN2, related to the recently described mouse Vanin-1 molecule involved in lymphocyte migration (M. Aurrand-Lions et al., 1996, Immunity 5: 391-405). Tissue distribution of the expression of these two human Vanin-like genes is differential. Since Vanin-1 shares significant homologies with human biotinidase (BTD), we describe here a new family of related genes including at least four members: mouse Vanin-1, VNN1, VNN2, and BTD. We have mapped the murine locus encompassing the Vanin-1 gene on mouse chromosome 10 in position A2B1. The two human Vanin-like genes are closely linked, since they were found on the same YAC clone and colocalized on human chromosome 6q23-q24 known to contain several genetic alterations linked to the progression of metastatic human cancers.
authors.affiliation: Centre d'Immunologie de Marseille Luminy, Universite de la Mediterranée, Marseille Cedex 09, France.
authors.forename: F
authors.initials: F
authors.lastname: Galland
authors.forename: F
authors.initials: F
authors.lastname: Malergue
authors.forename: H
authors.initials: H
authors.lastname: Bazin
authors.forename: M G
authors.initials: MG
authors.lastname: Mattei
authors.forename: M
authors.initials: M
authors.lastname: Aurrand-Lions
authors.forename: C
authors.initials: C
authors.lastname: Theillet
authors.forename: P
authors.initials: P
authors.lastname: Naquet
mesh_terms: D000581:Amidohydrolases / Q000235:genetics* / Q000378:metabolism*; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D043523:Biotinidase; D015815:Cell Adhesion Molecules / Q000235:genetics* / Q000378:metabolism*; D002896:Chromosomes, Human, Pair 6; D003001:Cloning, Molecular; D058851:GPI-Linked Proteins; D006801:Humans; D006867:Hydrolases; D051379:Mice; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction / Q000379:methods; D014176:Protein Biosynthesis; D011506:Proteins / Q000235:genetics* / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D015815:Cell Adhesion Molecules; D058851:GPI-Linked Proteins; D011506:Proteins; D006867:Hydrolases; D000581:Amidohydrolases; C022314:pantetheinase; D043523:Biotinidase; C121771:VNN2 protein, human