title: Peroxisomal and microsomal fatty acid oxidation in liver of rats after chronic ethanol consumption.
abstract: 1. Microsomal P450 and peroxisomal fatty acid oxidation activities were studied in liver of rats after long-term ethanol consumption. 2. Ethanol increased the microsomal lauric acid omega-hydroxylation and the aminopyrine N-demethylation catalyzed by cytochrome P450. 3. Ethanol increased peroxisomal beta-oxidation of palmitoyl CoA and catalase activity in liver. 4. Both microsomal and peroxisomal activities behaved in a coordinate way in the liver of rats with long-term ethanol consumption. 5. These results would support a role of microsomal omega-hydroxylation and peroxisomal beta-oxidation of fatty acids in an extramitochondrial pathway of lipid oxidation in the liver.
authors.affiliation: ICBM, Programa de Farmacología, Molecular Y Clínica, Facultad de Medicina, Universidad de Chile, Santiago. morellan@machi.med.uchile.cl
authors.forename: M
authors.initials: M
authors.lastname: Orellana
authors.forename: R
authors.initials: R
authors.lastname: Rodrigo
authors.forename: E
authors.initials: E
authors.lastname: Valdés
mesh_terms: D000428:Alcohol Drinking / Q000378:metabolism* / Q000473:pathology; D000632:Aminopyrine / Q000378:metabolism; D000818:Animals; D002374:Catalase / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism*; D006900:Hydroxylation; D007850:Lauric Acids / Q000378:metabolism; D015227:Lipid Peroxidation; D008099:Liver / Q000201:enzymology / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D008830:Microbodies / Q000201:enzymology / Q000378:metabolism*; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism*; D010084:Oxidation-Reduction; D010171:Palmitoyl Coenzyme A / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D005227:Fatty Acids; D007850:Lauric Acids; D000632:Aminopyrine; C030358:lauric acid; D010171:Palmitoyl Coenzyme A; D003577:Cytochrome P-450 Enzyme System; D002374:Catalase