[Induction of immune mediators in human cultured mononuclear cells by Marburg virus].
Infection of human mononuclear cells with Marburg virus results in production of inflammatory cytokines tumor necrosis factor and interleukin-1. These cytokines induce expression of adhesion receptors VCAM and ICAM by human endothelial cells. Mitogen-induced proliferation of human mononuclears is not suppressed 1 h after infection of these cells with Marburg virus in a dose of 0.01 PFU/cell. The capacity of cells to proliferate in response to mitogens significantly decreased 4 h after infection.
Ignat'ev
G M
GM
Strel'tsova
M A
MA
Kashentseva
E A
EA
D001483:Base Sequence; D002455:Cell Division; D002478:Cells, Cultured; D017931:DNA Primers; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis; D007375:Interleukin-1 / Q000096:biosynthesis* / Q000378:metabolism; D029024:Marburgvirus / Q000276:immunology*; D008934:Mitogens / Q000378:metabolism; D009000:Monocytes / Q000276:immunology* / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012692:Serial Passage; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis* / Q000378:metabolism; D019010:Vascular Cell Adhesion Molecule-1 / Q000096:biosynthesis
D017931:DNA Primers; D007375:Interleukin-1; D008934:Mitogens; D014409:Tumor Necrosis Factor-alpha; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1