title: Utility of certain pi-acceptors for the spectrophotometric determination of perindopril.
abstract: Simple, rapid, accurate and sensitive spectrophotometric methods are described for the determination of perindopril. The methods are based on the reaction of this drug as n-electron donor with 2,3-dichloro-5,6-dicyano-p-benzoquinone(DDQ)-7,7,8,8- tetracyanoquinodimethane (TCNQ), tetracyanoethylene (TCNE), chloranil (CL) and p-chloranilic acid (p-CA) as pi-acceptors to give highly coloured complex species. The coloured products are measured spectrophotometrically at 588, 843, 419, 550 and 520 nm for DDQ, TCNQ, TCNE, CL and p-CA, respectively, optimization of different experimental conditions is described. Beer's law is obeyed in the range of 20-200 micrograms ml-1 and colours were produced in non-aqueous media and were stable for at least 1 h. Application of the suggested methods to perindopril tablets are presented.
authors.affiliation: Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Egypt.
authors.forename: H E
authors.initials: HE
authors.lastname: Abdellatef
mesh_terms: D000959:Antihypertensive Agents / Q000032:analysis* / Q000737:chemistry; D016227:Benzoquinones / Q000737:chemistry; D002703:Chloranil / Q000737:chemistry; D005030:Ethylenes / Q000737:chemistry; D007202:Indicators and Reagents / Q000737:chemistry; D007211:Indoles / Q000032:analysis* / Q000737:chemistry; D009570:Nitriles / Q000737:chemistry; D020913:Perindopril; D013053:Spectrophotometry / Q000379:methods*
chemical_list: D000959:Antihypertensive Agents; D016227:Benzoquinones; D005030:Ethylenes; D007202:Indicators and Reagents; D007211:Indoles; D009570:Nitriles; D002703:Chloranil; C013703:tetracyanoquinodimethane; C000928:dichlorodicyanobenzoquinone; C003393:tetracyanoethylene; D020913:Perindopril; C014400:chloranilic acid