Effects of chocolate cyst fluid on endometrioma cell growth in culture.
OBJECTIVE
To evaluate the effect of chocolate cyst fluid on the proliferation of cultured human endometrioma cells and to assay the concentration of transforming growth factor-B1 in this fluid.


METHODS
Controlled in vitro study.


METHODS
Department of Obstetrics and Gynecology, State University of New York Health Science Center.


METHODS
Five women with ovarian endometriomas.


METHODS
Endometrioma tissue and chocolate fluid from five different patients were entered in this study.


METHODS
Endometrioma cell proliferation in culture with and without chocolate cyst fluid.


RESULTS
Chocolate cyst fluid increased the proliferation of endometrioma cells compared with controls. Also, high concentrations of transforming growth factor-B1 were found in cysts' fluid.


CONCLUSIONS
Chocolate cyst fluid has a growth-enhancing effect on endometrioma cells. One promoting growth factor is transforming growth factor-B1.
Badawy
S Z
SZ
Department of Obstetrics and Gynecology, State University of New York, Health Science Center, Syracuse 13210, USA.
Cuenca
V
V
Kumar
S
S
Holland
J
J
D002452:Cell Count; D002455:Cell Division / Q000502:physiology; D002478:Cells, Cultured; D020420:Cyst Fluid / Q000378:metabolism / Q000502:physiology*; D004715:Endometriosis / Q000473:pathology / Q000503:physiopathology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D010048:Ovarian Cysts / Q000378:metabolism / Q000503:physiopathology*; D016212:Transforming Growth Factor beta / Q000378:metabolism
D016212:Transforming Growth Factor beta