title: [Effect of hemin in treating hemorrhagic anemia and toxicity].
abstract: OBJECTIVE
  To study the effect of hemin in treating hemorrhagic anemia and toxicity.
  
  
  METHODS
  Fifty rats with hemorrhagic anemia were randomly divided into 5 groups with different dosage of hemin (93, 168, 300 mg.kg-1.d-1), ferrous gluconate (FG 300 mg.kg-1.d-1), and water, ig for 7 d. Twenty mice fed with hemin (6.0 g.kg-1.d-1) in 24 h for observing acute toxicity effects. Long-term toxicity were observed in 80 rats given hemin (0.65, 1.3, 2.6 g.kg-1.d-1) in 3 months.
  
  
  RESULTS
  Hb of the rats of corresponding groups were 66-->121, 71-->141, 66-->148, 69-->140, and 67-->112 g.L-1. There were no adverse effects observed on acute toxicity test. No abnormalitis were found in hemogram, liver renal function test, and autopsy.
  
  
  CONCLUSIONS
  Hemin had a better effect than FG and no adverse effect was found in hemin.
authors.affiliation: Department of Pharmacology, Fujian Medical College, Fuzhou, China.
authors.forename: K S
authors.initials: KS
authors.lastname: You
authors.forename: B
authors.initials: B
authors.lastname: Wu
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Huang
authors.forename: C
authors.initials: C
authors.lastname: Zhang
authors.forename: L J
authors.initials: LJ
authors.lastname: Pan
authors.forename: G T
authors.initials: GT
authors.lastname: Wu
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Zhao
authors.forename: M H
authors.initials: MH
authors.lastname: Huang
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000188:drug therapy* / Q000209:etiology; D000818:Animals; D005260:Female; D005296:Ferrous Compounds / Q000627:therapeutic use; D006427:Hemin / Q000627:therapeutic use* / Q000633:toxicity; D006470:Hemorrhage / Q000150:complications; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D005296:Ferrous Compounds; D006427:Hemin; C011819:ferrous gluconate