Inhibitory effect of anaphylactic reaction of Sosiho-Tang.
Mast cells synthesize and secrete chemical mediators which play an central role in anaphylactic reactions. Compound 48/80 is a condensation product of formaldehyde with paramethoxyphenylethylamine that reliably induces the release of chemical mediators in the mast cell granules. Aggregation of the high-affinity Fc receptor also stimulates the mast cells. The objective of the current study was to determine the effect of Sosiho-Tang (SS-Tang) on mast cell-mediated anaphylactic reaction. SS-Tang completely inhibited systemic anaphylaxis induced by compound 48/80 in mice. SS-Tang inhibited local anaphylaxis induced by anti-dinitrophenyl (DNP) IgE. In addition SS-Tang concentration-dependently inhibited histamine release in mast cells induced by compound 48/80 or anti-DNP IgE. These results indicate that SS-Tang may contain compounds with actions that inhibit mast cell degranulation.
Kim
H M
HM
College of Pharmacy, Wonkwang University, Iksan, Chonbuk, South Korea.
Kim
Y Y
YY
Moon
H S
HS
Lee
E H
EH
Moon
S J
SJ
An
N H
NH
D000818:Animals; D004136:Dinitrobenzenes / Q000276:immunology; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006636:Histamine Release / Q000187:drug effects; D007073:Immunoglobulin E / Q000276:immunology; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects* / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar; D003189:p-Methoxy-N-methylphenethylamine / Q000276:immunology / Q000633:toxicity
D004136:Dinitrobenzenes; D004365:Drugs, Chinese Herbal; D007073:Immunoglobulin E; D003189:p-Methoxy-N-methylphenethylamine