title: Pulmonary arterial and right ventricular responses to prophylactic albumin administration before aortic unclamping during abdominal aortic aneurysmectomy.
abstract: During abdominal aortic aneurysmectomy (AAAectomy) and before aortic unclamping (XU), we studied the effects of albumin administration on pulmonary arterial and right ventricular responses in 39 anesthetized patients using a modified thermodilution technique. Group 1 patients (n = 18) were given no extra IV fluids. Group 2 patients (n = 21) were given additional albumin administration (5% albumin at 10 mL/kg) before XU. After XU, mean arterial blood pressure (MAP) decreased significantly in each group, and MAP and stroke volume index (SVI) were not significantly higher in Group 2 than in Group 1. At 5 min after XU, the patients in Group 2 had a higher mean pulmonary arterial pressure and pulmonary vascular resistance index and a lower right ventricular ejection fraction than those in Group 1 (P < 0.05), but their SVIs were well maintained. These results indicate that albumin administration before XU may not always prevent post-XU hypotension. It caused a significant increase in right ventricular afterload and a significant dilation of the right ventricular cavity; however, right ventricular function was almost equally maintained in both groups. However, because SVI did not increase in some patients (Group 2) with the increase in right ventricular end-diastolic volume index after XU, albumin administration should be performed carefully before XU during AAAectomy.
  
  
  CONCLUSIONS
  We studied the effects of albumin administration before aortic unclamping on pulmonary arterial and right ventricular responses during abdominal aortic aneurysmectomy using a modified thermodilution technique. Albumin administration before aortic unclamping may not always prevent hypotension, and it may cause a higher pulmonary arterial pressure than in patients without albumin administration.
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Gifu University School of Medicine, Gifu City, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Ueda
authors.forename: S
authors.initials: S
authors.lastname: Dohi
authors.forename: S
authors.initials: S
authors.lastname: Akamatsu
authors.forename: Y
authors.initials: Y
authors.lastname: Hamaya
authors.forename: E
authors.initials: E
authors.lastname: Terazawa
authors.forename: H
authors.initials: H
authors.lastname: Shimonaka
authors.forename: H
authors.initials: H
authors.lastname: Ohata
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000418:Albumins / Q000627:therapeutic use*; D017544:Aortic Aneurysm, Abdominal / Q000601:surgery*; D001794:Blood Pressure / Q000187:drug effects; D003250:Constriction; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011651:Pulmonary Artery / Q000187:drug effects* / Q000502:physiology; D013815:Thermodilution; D016278:Ventricular Function, Right / Q000187:drug effects* / Q000502:physiology
chemical_list: D000418:Albumins