Priming with L-DOPA differently affects dynorphin and substance P mRNA levels in the striatum of 6-hydroxydopamine-lesioned rats after challenge with dopamine D1-receptor agonist.
In unilaterally 6-hydroxydopamine-lesioned rats, potentiation of D1-agonist-induced turning behavior by priming with l-DOPA was correlated with changes in striatal neuropeptide mRNA levels. In non-primed rats, administration of the D1-agonist SKF-38393 markedly increased dynorphin and substance P mRNA levels in the lesioned striatum. Priming with l-DOPA dissociated the response of the two neuropeptides to the D1-agonist, with higher dynorphin and reduced substance P mRNA levels.
van de Witte
S V
SV
Research Institute Neurosciences, Vrije Universiteit, Department of Anatomy/Embryology, van der Boechorstraat 7, 1081 BT, Amsterdam, Netherlands. sv.van_de_witte.anat@med.vu.nl
Drukarch
B
B
Stoof
J C
JC
Voorn
P
P
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D001921:Brain; D003342:Corpus Striatum / Q000737:chemistry / Q000187:drug effects*; D004399:Dynorphins / Q000235:genetics*; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D007980:Levodopa / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D016627:Oxidopamine / Q000008:administration & dosage / Q000494:pharmacology*; D012333:RNA, Messenger / Q000032:analysis / Q000096:biosynthesis* / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D017447:Receptors, Dopamine D1 / Q000819:agonists*; D013238:Stereotaxic Techniques; D013373:Substance P / Q000235:genetics*
D012333:RNA, Messenger; D017447:Receptors, Dopamine D1; D013373:Substance P; D007980:Levodopa; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D004399:Dynorphins; D016627:Oxidopamine