Central nervous system reactions associated with famotidine: report of five cases.
H2-receptor antagonists may cause various types of central nervous system reactions, particularly in patients with advanced age and/or impaired renal or liver function. These reactions have rarely been reported in association with famotidine. In five elderly patients, four of them with renal failure, central nervous system reactions developed shortly after initiation with famotidine therapy. These adverse reactions completely resolved after famotidine withdrawal. The authors' five cases and the other seven previously reported emphasize the need for dosage adjustment of famotidine in elderly patients and in those with renal failure, and that these patients should be carefully monitored for development of central nervous system reactions, which sometimes could be very serious.
Odeh
M
M
Department of Internal Medicine B, Bnai Zion Medical Center, and the Technion Faculty of Medicine, Israel Institute of Technology, Haifa, Israel.
Oliven
A
A
D000368:Aged; D000369:Aged, 80 and over; D000897:Anti-Ulcer Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001927:Brain Diseases / Q000139:chemically induced* / Q000175:diagnosis; D015738:Famotidine / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006635:Histamine H2 Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000188:drug therapy*
D000897:Anti-Ulcer Agents; D006635:Histamine H2 Antagonists; D015738:Famotidine