[Anti-tumor effects of ailing-1 on human megakaryoblastic leukemia cells].
OBJECTIVE
To evaluate the anti-cancer effect of Ailing-1 on human megakaryoblastic leukemia cells in culture.


METHODS
Using living cell counting, 3H-TdR incorporation and clonal proliferation assay.


RESULTS
Ailing-1 has various cytotoxicity on cell level, DNA synthesis and clone proliferation and shows good does-effect relation. The ED50 of Ailing-1 is greater than that of homoharringtonine through three different methods, consistent with the clinical result. Drug resistance has not been found.


CONCLUSIONS
Ailing-1 is a promising anti-tumor drug.
Duan
X M
XM
Second Hospital of Tianjin Medical University.
Xu
J S
JS
Xin
X M
XM
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006248:Harringtonines / Q000494:pharmacology; D000077863:Homoharringtonine; D006801:Humans; D007947:Leukemia, Megakaryoblastic, Acute / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000972:Antineoplastic Agents, Phytogenic; D004273:DNA, Neoplasm; D004365:Drugs, Chinese Herbal; D006248:Harringtonines; D000077863:Homoharringtonine