Genetic dissection of glucocorticoid receptor function in mice.
Upon hormone binding, the activated glucocorticoid receptor (GR) functions as a transcription factor via different modes of action to control gene expression. Recent gene-targeting studies in mice provide new insight into the role of GR in vivo and are helping decipher the molecular mechanisms underlying its actions.
Tronche
F
F
Molecular Biology of the Cell I, Deutsches Krebsforschungzentrum, Im Neuenheimer Feld 280, 69120, Heidelberg, Federal Republic of Germany.
Kellendonk
C
C
Reichardt
H M
HM
Schütz
G
G
D000818:Animals; D005786:Gene Expression Regulation; D006706:Homeostasis; D051379:Mice; D008954:Models, Biological; D011965:Receptors, Glucocorticoid / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D015398:Signal Transduction; D013312:Stress, Physiological; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic
D011965:Receptors, Glucocorticoid; D014157:Transcription Factors