Prophylaxis of cystine calculi by low dose of alpha-mercapto-propionyl-glycine administered every other day.
In a case of typical cystinuria type I with left kidney hypoplasia and bilateral calculosis, calculi were dissolved by means of alpha-mercapto-propionyl-glycine and prophylaxis of the calculosis was performed by the same drug continuously administered in two divided doses (10-4 mg.kg-1.day-1) for 9 years, without urolithiasis. Then, the alpha-mercaptopropionyl-glycine every other day in one dose, 4 mg.kg-1.day-1, for two years was administered without calculosis. The arbitrary discontinuation of the drug by the patient was followed after 6 months from a right ureteral calculosis with transitory renal insufficiency. In our case the administration of a low dose of alpha-mercapto-propionyl-glycine every other day was useful in cystine calculosis prophylaxis.
Berio
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Chair of Pediatrics, University of Genoa, Institute G. Gaslini, Italy.
Piazzi
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D000328:Adult; D003555:Cystinuria / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D007669:Kidney Calculi / Q000517:prevention & control*; D008297:Male; D008625:Tiopronin / Q000627:therapeutic use*
D008625:Tiopronin