title: Minimally invasive coronary surgery: surgical considerations and assessment of cardiac troponin I.
abstract: OBJECTIVE
  Minimally invasive coronary artery bypass grafting (MICABG) using internal thoracic artery (ITA) without median sternotomy and cardiopulmonary bypass (CPB) become a viable option for the management of proximal left anterior descending artery (LAD) disease. Recent studies have demonstrated that cardiac troponine I (cTnI), a new highly specific diagnostic marker of cardiomyocyte damage, is a reliable marker of cardiac ischemia during heart operations under CPB.
  
  
  METHODS
  Between February 1996 and April 1997, 14 patients (10 males, 4 females aged 41-68) underwent MICABG with single-vessel bypass grafting for LAD stenosis (n = 9) or occlusion (n = 5). Video-assisted surgery with left anterior mini-thoracotomy was performed in ten patients and vertical parasternal thoracotomy in the other four. cTnI was measured before LAD occlusion (T0), during anastomosis (T1) and 10 min (T2), 6 h (T3), 24 h (T4), 48 h (T5), 72 h (T6) after coronary reperfusion. Assay methods used a specific enzyme-linked immunosorbent autoanalyzer (Stratus) in peripheral venous blood. Control coronary angiography was performed in all patients.
  
  
  RESULTS
  There were no operative complications, no reoperations for bleeding. cTnI concentrations were expressed in ng/ml +/- SD. Mean cTnI level was <3.85+/-1 ng/ml (range 0-32.8). Values were: T0 = 0, T1 = 0.5+/-0.1, T2 = 1.15+/-0.2, T3 = 2.16+/-0.6, T4 = 1.5+/-0.3, T5 = 0.6+/-0.02, T6 = 0.4+/-0.01. Angiography showed patent grafts in 12 patients. A 'no flow situation' was demonstrated in a cardiac symptom-free patient, with reestablishment of flow on repeat angiogram at 6 months. In the other case, early ITA graft occlusion in a patient with two-vessel disease was correlated with a higher cTnI concentration (17.8 ng/ml). Percutaneous angioplasty was performed on the right coronary artery, complicated with dissection and cardiac failure. This patient died 3 months after the MICABG despite ventricular assist device.
  
  
  CONCLUSIONS
  cTnI did not increase during and after coronary artery occlusion and local immobilization of the heart. It can be used to evaluate postoperative myocardial damage on the beating heart using MICABG.
authors.affiliation: Thoracic and Cardiovascular Surgery Department, University Hospital CHU Caen, Cote de Nacre, France.
authors.forename: G
authors.initials: G
authors.lastname: Babatasi
authors.forename: M
authors.initials: M
authors.lastname: Massetti
authors.forename: P
authors.initials: P
authors.lastname: Nataf
authors.forename: S
authors.initials: S
authors.lastname: Fradin
authors.forename: D
authors.initials: D
authors.lastname: Agostini
authors.forename: G
authors.initials: G
authors.lastname: Grollier
authors.forename: J L
authors.initials: JL
authors.lastname: Gerard
authors.forename: A
authors.initials: A
authors.lastname: Khayat
mesh_terms: D003327:Coronary Disease / Q000601:surgery; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007387:Internal Mammary-Coronary Artery Anastomosis; D007431:Intraoperative Complications / Q000097:blood / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis*; D011183:Postoperative Complications / Q000097:blood / Q000175:diagnosis*; D013908:Thoracotomy; D019210:Troponin I / Q000097:blood*
chemical_list: D019210:Troponin I