Cytogenetic analysis of 11 renal oncocytomas: further evidence of structural rearrangements of 11q13 as a characteristic chromosomal anomaly.
We carried out cytogenetic analysis on 11 renal oncotytomas by using G-banding and DAPI-banding techniques. Four of our tumors exhibited structural rearrangements affecting chromosome 11 at band q13. Together with another case previously described by us, our tumors constitute the largest series of renal oncocytomas displaying translocations involving 11q13. A review of the literature disclosed only 6 similar oncocytomas, 1 tumor with a t(9;11)(p23;q12), 2 tumors with a nearly identical t(9;11)(p23;q13), and 3 tumors with a t(5;11)(q35;q13). Therefore, our findings provide further cytogenetic evidence that genes located on 11q12-13 may be involved in the tumorigenesis of renal oncocytomas.
Füzesi
L
L
Institute of Pathology, Medical School of the Technical University, Aachen, Germany.
Gunawan
B
B
Braun
S
S
Bergmann
F
F
Brauers
A
A
Effert
P
P
Mittermayer
C
C
D018249:Adenoma, Oxyphilic / Q000235:genetics* / Q000473:pathology; D000328:Adult; D000368:Aged; D007446:Chromosome Inversion; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D014178:Translocation, Genetic
D005819:Genetic Markers