Explaining on request a correlation between membrane Na,K-ATPase and K+ content in erythrocytes and other findings in the preceding paper.
In response to the request of the authors of the preceding paper, this article explains three observations they and others had made in the context of the association-induction hypothesis. (1) Why is Rb+ accumulated in human red blood cells not released when transferred to a Rb(+)-free Hank's solution? (2) Why ouabain, which reduces Rb+ uptake by red blood cells, does not release this ion from Rb(+)-loaded red blood cells? (3) Why is there a positive correlation between the K+ contents of the red blood cells of different mammals and the Na,K-ATPase isolated from the red blood cells of the same mammals?
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Damadian Foundation for Basic and Cancer Research, Fonar Corporation, Melville, NY 11747, USA. gilbertling@dobar.org
D000818:Animals; D004910:Erythrocyte Membrane / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D006706:Homeostasis; D006736:Horses; D006801:Humans; D008954:Models, Biological; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000097:blood*; D012413:Rubidium / Q000097:blood; D012756:Sheep; D012964:Sodium / Q000097:blood; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood*
D010042:Ouabain; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D012413:Rubidium; D011188:Potassium