Accumulation of F-spondin in injured peripheral nerve promotes the outgrowth of sensory axons.
F-spondin, an extracellular matrix protein, is present in peripheral nerve during embryonic development, but its amount diminishes by birth. Axotomy of adult rat sciatic nerve, however, causes a massive upregulation of both F-spondin mRNA and protein distal to the lesion. F-spondin in the distal stump of axotomized nerve promotes neurite outgrowth of sensory neurons, as revealed by protein neutralization with F-spondin-specific antibodies. Thus, F-spondin is likely to play a role in promoting axonal regeneration after nerve injury.
Burstyn-Cohen
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T
Department of Anatomy and Cell Biology, The Hebrew University-Hadassah Medical School, Jerusalem, 91120 Israel.
Frumkin
A
A
Xu
Y T
YT
Scherer
S S
SS
Klar
A
A
D000818:Animals; D000831:Animals, Newborn; D000906:Antibodies / Q000494:pharmacology; D001369:Axons / Q000502:physiology*; D019771:Axotomy; D015152:Blotting, Northern; D002478:Cells, Cultured; D005109:Extracellular Matrix / Q000378:metabolism; D005786:Gene Expression Regulation; D006133:Growth Substances; D017403:In Situ Hybridization; D036341:Intercellular Signaling Peptides and Proteins; D009416:Nerve Regeneration; D019006:Neural Cell Adhesion Molecules / Q000276:immunology / Q000378:metabolism*; D016501:Neurites / Q000187:drug effects / Q000502:physiology; D009475:Neurons, Afferent / Q000502:physiology*; D010455:Peptides; D059348:Peripheral Nerve Injuries; D010525:Peripheral Nerves / Q000196:embryology / Q000378:metabolism*; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017207:Rats, Sprague-Dawley; D012583:Schwann Cells; D012584:Sciatic Nerve
D000906:Antibodies; D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins; D019006:Neural Cell Adhesion Molecules; D010455:Peptides; D012333:RNA, Messenger; C498955:Spon1 protein, rat