A new drug delivery system--ciprofloxacine/tricalcium phosphate delivery capsule (CTDC) and its in vitro drug release pattern.
A new drug delivery system (DDS), ciprofloxacine/tricalcium phosphate delivery capsule (CTDC) was developed by loading a broad-spectrum antibiotic ciprofloxacine into the central cylindrical cavity of tricalcium phosphate capsule. The new system showed good biocompatibility and could degrade gradually in our preliminary studies. In vitro study showed that CTDC could maintain high-level and long-term release of ciprofloxacine and that ultrasonic irradiation within the range of physical therapy could increase the drug release amount from CTDC ( P < 0.02), and might become a new technique to achieve the control of drug release from DDS.
Wu
H
H
Department of Orthopedics, Xiehe Hospital, Tongji Medical University, Wuhan.
Zheng
O
O
Du
J
J
Yan
Y
Y
Liu
C
C
D000890:Anti-Infective Agents / Q000008:administration & dosage*; D002130:Calcium Phosphates / Q000008:administration & dosage*; D002214:Capsules; D002516:Ceramics; D002939:Ciprofloxacin / Q000008:administration & dosage*; D004337:Drug Carriers; D016503:Drug Delivery Systems; D006801:Humans; D014465:Ultrasonics
D000890:Anti-Infective Agents; D002130:Calcium Phosphates; D002214:Capsules; D004337:Drug Carriers; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; D002939:Ciprofloxacin; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous