In vitro characterization of poly(ethylene) glycol calcium citrate microspheres as a delivery system for the study of reparative dentinogenesis.
The characterization of poly(ethylene) glycol calcium citrate microspheres is described. The calcium content and content uniformity of microspheres, prepared at five concentrations ranging from 46.56 micrograms/g to 81.49 mg/g, were determined by spectroscopy. Under sink conditions first-order in vitro dissolution kinetics were observed. Granules containing approximately 80 mg Ca++/g PEG gave an in vitro calcium release over a 3-day period similar to that of a calcium hydroxide product, Pulpdent.
Hunter
A R
AR
Department of Oral Rehabilitation, University of Otago, Dunedin, New Zealand.
Kirk
E E
EE
Robinson
D H
DH
Kardos
T B
TB
D000818:Animals; D002021:Buffers; D002118:Calcium / Q000008:administration & dosage* / Q000032:analysis; D019355:Calcium Citrate / Q000008:administration & dosage / Q000737:chemistry; D003785:Dental Pulp Capping; D003809:Dentin, Secondary / Q000254:growth & development; D003810:Dentinogenesis; D016503:Drug Delivery Systems; D015195:Drug Design; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D010949:Plasma; D011092:Polyethylene Glycols; D051381:Rats; D012044:Regression Analysis
D002021:Buffers; D011092:Polyethylene Glycols; D019355:Calcium Citrate; D002118:Calcium