Evaluation of once-weekly therapy for tuberculosis using isoniazid plus rifamycins in the mouse aerosol infection model.
Once-weekly therapy with combinations of isoniazid plus a rifamycin was tested in the mouse low-dose aerosol infection model against two strains of Mycobacterium tuberculosis. Combinations of isoniazid and rifalizil and isoniazid and rifapentine were both highly effective. These animal model data thus support the evaluation of these regimens under clinical conditions.
Brooks
J V
JV
Mycobacteria Research Laboratories, Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523, USA.
Orme
I M
IM
D000336:Aerosols; D000818:Animals; D000995:Antitubercular Agents / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D007538:Isoniazid / Q000008:administration & dosage*; D051379:Mice; D008810:Mice, Inbred C57BL; D012294:Rifamycins / Q000008:administration & dosage*; D014376:Tuberculosis / Q000188:drug therapy*
D000336:Aerosols; D000995:Antitubercular Agents; D012294:Rifamycins; D007538:Isoniazid