Quantitative trait loci implicated in corpus callosum midsagittal area in mice.
The midsagittal area of the corpus callosum expressed as the percentage of the hemispheric surface is smaller in the NZB/BlNJ than in the C57BL/6By inbred strain of mice. We performed a QTL mapping analysis using 284 F2s. Two loci linked to this measure were found: the CCrSQTL1 and CCrSQTL2 at 87 and 67 centiMorgans from the centromere on chromosomes 1 and 4 respectively. The two loci interacted significantly. The total source of genetic variation contributed to 25% of the observed variance.
Roy
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UPR CNRS 9074, Génétique, Neurogénétique, Comportement, Institut de Transgénose, CNRS, 3 B Rue de la Ferollerie, 45071, Orléans Cedex 02, France.
Perez-Diaz
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Roubertoux
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D000818:Animals; D002874:Chromosome Mapping; D020090:Chromosome Segregation; D003337:Corpus Callosum / Q000502:physiology*; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D019655:Quantitative Trait, Heritable