title: The role of sodium in the in vivo absorption of glycine by the intestine of the amphibian discoglossus pictus.
abstract: This work showed that sodium deficit in the incubation medium causes a decrease in oxygen consumption of the isolated intestine. Replacement of 33% and 66% sodium by equivalent quantities of potassium provoked respective inhibitions of 43.5% and 44%. Total replacement of sodium induced an inhibition of 51.7%. Under in vivo conditions, sodium deficit in the luminal fluid led to lower glycine absorption. This inhibition was 7.9% in 5/1000 NaCl, from 16.8% in 2.5/1000 NaCl and 27.4% when sodium was totally replaced by potassium. The quantity of glycine retained by the intestinal wall in vivo was inversely proportional to sodium concentration in the intestine. We conclude from the latter result that the presence of sodium in the lumen appears to stimulate glycine transport across the basolateral membrane of the intestine.
authors.affiliation: Laboratoire de Physiologie, Faculté de Pharmacie, Monastir, Tunisie.
authors.forename: D
authors.initials: D
authors.lastname: Saidane
authors.forename: B
authors.initials: B
authors.lastname: Tritar
mesh_terms: D000818:Animals; D001001:Anura / Q000378:metabolism*; D005998:Glycine / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism*; D010101:Oxygen Consumption; D012964:Sodium / Q000378:metabolism*
chemical_list: D012964:Sodium; D005998:Glycine