[Clinical and experimental studies on elimination of oxygen free radical of jinshuibao capsule in treating senile deficiency syndrome and its deoxyribonucleic acid damage repairing effects].
OBJECTIVE
To observe the efficacy of Jinshuibao capsule.


METHODS
Senile patients of Deficiency Syndrome treated with Jinshuibao capsule (JSBC) as treated group and with starch capsule as control group. JSBC is a preparation of Cordyceps sinensis.


RESULTS
(1) The superoxide dismutase (SOD) activity in senile patient were markedly lower than that in youth, while the malonyldialdehyde (MDA) level of the former was higher than that of the latter, P < 0.01; (2) The SOD activity increased and the MDA level decreased in the treated group after treatment, P < 0.01. JSBC also revealed satisfactory effect on relieving symptoms such as chilling, dizziness, lassitude in loin and legs, frequent nocturia and tinnitus, etc. Results of animal experiment wese in accordance with that of clinical observation. The unscheduled deoxyribonucleic synthesis (UDS) level of aged group before treatment was obviously lower than that of youth; after treatment, the change was very significant, and the difference between treated group and control group was also very significant (P < 0.01). Animal experiment showed that the sister chromatid exchange (SCE) of splenic cell in young mice group was markedly lower than that in aged mouse group.


CONCLUSIONS
JSBC has not showed the SCE inducting effect, but could accelerate the repairing of damaged deoxyribonucleic acid (DNA).
Zhang
Z J
ZJ
Second Affiliated Hospital of Jiangxi Medical College, Nanchang.
Luo
H L
HL
Li
J S
JS
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood / Q000187:drug effects*; D000818:Animals; D004260:DNA Repair / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D016166:Free Radical Scavengers / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D051379:Mice; D008875:Middle Aged; D009036:Moths; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012854:Sister Chromatid Exchange; D013482:Superoxide Dismutase / Q000097:blood*; D013098:Xylariales; D016711:Yang Deficiency / Q000188:drug therapy*
D004365:Drugs, Chinese Herbal; D016166:Free Radical Scavengers; D008315:Malondialdehyde; D013482:Superoxide Dismutase