Cytostatic activity of some compounds from the unsaponifiable fraction obtained from virgin olive oil.
Oleuropein, tyrosol, squalene and the fraction of sterols and triterpenoid dialcohols from the unsaponifiable fraction obtained from virgin olive oil have been tested for possible cytostatic activity against McCoy cells, using 6-mercaptopurine as a positive control. The samples of sterols and triterpenic dialcohols showed a strong activity.
Saenz
M T
MT
Laboratori do Farmacognosia, Universidad de Sevilla, 41012 Seville, Spain
Garcia
M D
MD
Ahumada
M C
MC
Ruiz
V
V
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D006801:Humans; D057888:Iridoid Glucosides; D039823:Iridoids; D000069463:Olive Oil; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives / Q000494:pharmacology; D010938:Plant Oils / Q000737:chemistry*; D011714:Pyrans / Q000494:pharmacology; D013185:Squalene / Q000494:pharmacology; D013261:Sterols / Q000494:pharmacology; D014315:Triterpenes / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D057888:Iridoid Glucosides; D039823:Iridoids; D000069463:Olive Oil; D010938:Plant Oils; D011714:Pyrans; D013261:Sterols; D014315:Triterpenes; C011867:4-hydroxyphenylethanol; C002769:oleuropein; D013185:Squalene; D010626:Phenylethyl Alcohol