Efficacy of topical sensitizers in the treatment of alopecia areata.
It has been more than 2 decades since the first report of the use of dinitrochlorobenzene to induce hair growth in 2 patients with alopecia areata. Other topical sensitizers, namely squaric acid dibutylester and diphenylcyclopropenone, have been used with variable success. This article reviews the efficacy and safety of the use of topical sensitizers in the treatment of alopecia areata.
Rokhsar
C K
CK
The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York 10016, USA.
Shupack
J L
JL
Vafai
J J
JJ
Washenik
K
K
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D000279:Administration, Cutaneous; D000506:Alopecia Areata / Q000188:drug therapy*; D003503:Cyclobutanes / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D003521:Cyclopropanes / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D006197:Hair / Q000187:drug effects*; D006801:Humans; D011379:Prognosis; D012449:Safety
D000276:Adjuvants, Immunologic; D003503:Cyclobutanes; D003521:Cyclopropanes; C020637:squaric acid dibutyl ester; C029402:diphenylcyclopropenone