Finite element analysis of defibrillation fields in a human torso model for ventricular defibrillation.
In order to optimize defibrillation electrode systems for ventricular defibrillation thresholds (DFTs), a Finite Element Torso model was built from fast CT scans of a patient who had large cardiac dimensions (upper bound of normal) but no heart disease. Clinically used defibrillation electrode configurations, i.e. Superior Vena Cava (SVC) to Right Ventricle (RV) (SVC-RV), left pectoral Can to RV (Can-RV) and Can + SVC-RV, were analyzed. The DFTs were calculated based on 95% ventricular mass having voltage gradient > 5 V/cm and these results were also compared with clinical data. The low voltage gradient regions with voltage gradient < 5 V/cm were identified and the effect of electrode dimension and location on DFTs were also investigated for each system. A good correlation between the model results and the clinical data supports the use of Finite Element Analysis of a human torso model for optimization of defibrillation electrode systems. This correlation also indicates that the critical mass hypothesis is the primary mechanism of defibrillation. Both the FEA results and the clinical data show that Can + SVC-RV system offers the lowest voltage DFTs when compared with SVC-RV and Can-RV systems. Analysis of the effect of RV, SVC and Can electrode dimensions and locations can have an important impact on defibrillation lead designs.
Min
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Medtronic, Minneapolis, MN 55432, USA. shirley.min@medtronic.com
Mehra
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D019295:Computational Biology / Q000379:methods; D016757:Death, Sudden, Cardiac / Q000209:etiology; D004554:Electric Countershock; D004867:Equipment Design; D006321:Heart / Q000033:anatomy & histology* / Q000000981:diagnostic imaging / Q000502:physiology* / Q000503:physiopathology; D006801:Humans; D008953:Models, Anatomic; D008955:Models, Cardiovascular; D014057:Tomography, X-Ray Computed; D014683:Vena Cava, Superior / Q000503:physiopathology; D014693:Ventricular Fibrillation / Q000150:complications / Q000503:physiopathology* / Q000628:therapy*; D016278:Ventricular Function, Right / Q000502:physiology