Giant cell granulamatous hypophysitis with remarkable uptake on Gallium-67 scintigraphy.
We treated a man with giant cell granulomatous hypophysitis with pituitary enlargement, as seen on magnetic resonance imaging. Endocrinological examination revealed panhypopituitarism and diabetes insipidus. Microscopic examination of the specimen obtained by transsphenoidal pituitary biopsy revealed a granulomatous lesion, composed of epitheliod cells, Langhans' multinucleated giant cells, lymphocytes and other chronic inflammatory cells. On whole body gallium-67 scintigraphy, there was extensive uptake in the pituitary gland. Gallium-67 scintigraphy may greatly aid in the diagnosis of granulomatous hypophysitis.
Shimizu
C
C
Department of Medicine II, Hokkaido University School of Medicine, Sapporo, Japan.
Kubo
M
M
Kijima
H
H
Ishizu
A
A
Katoh
T
T
Koike
T
T
D000328:Adult; D005710:Gallium Radioisotopes; D006101:Granuloma, Giant Cell / Q000000981:diagnostic imaging*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010900:Pituitary Diseases / Q000000981:diagnostic imaging*; D010902:Pituitary Gland / Q000000981:diagnostic imaging* / Q000473:pathology; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals
D005710:Gallium Radioisotopes; D019275:Radiopharmaceuticals