Hyperprolactinemia: an inductor of neoplastic changes in endometrium? A report of two cases.
Estrogen-dependent endometrial carcinomas habitually arise through a precursor lesion such as endometrial hyperplasia. The hormonal environment of these patients remains unclear. Two cases of neoplastic changes in the endometrium of patients with a chronic hyperprolactinemia are presented. Despite the treatment with bromocriptine both patients developed endometrial adenocarcinomas. Possible mechanisms involved in the pathogenesis of these tumors are discussed.
Dexeus
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S
Department of Obstetrics and Gynecology, Institut Universitari Dexeus, Universitat Autònoma de Barcelona, Spain.
Barri
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PN
D000230:Adenocarcinoma / Q000209:etiology* / Q000517:prevention & control / Q000601:surgery; D000328:Adult; D001971:Bromocriptine / Q000627:therapeutic use; D016889:Endometrial Neoplasms / Q000209:etiology* / Q000517:prevention & control / Q000601:surgery; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000150:complications* / Q000188:drug therapy; D007044:Hysterectomy
D001971:Bromocriptine