title: Evolution of headache in childhood and adolescence: an 8-year follow-up.
abstract: OBJECTIVE
  Headache is a notable problem in clinical practice and a frequent symptom in childhood and adolescence. The main aim of the present study is to analyze the evolution of migraine and tension headache (TH) using an 8-year follow-up.
  
  
  METHODS
  100 subjects (F60, M40; mean age 17.9; SD 2.6; range 12-26), randomly selected among all patients first seen in 1988 at the Headache Center, were directly contacted. We employed IHS criteria both in 1988 (the data were taken by the clinical charts) and 1996. We took into account changes in headache types and improvement, unchanging, worsening or remission of headache. This analysis was made with regard to gender differences and age at onset of headache, too. The chi-squared test is employed.
  
  
  RESULTS
  High tendency to remit (34%) or improve (45%) was recorded. A worsening situation was seen in 6% and an unchanging situation in 15%. In 1988, we had 57% migraine without aura (MwoA), 7% migraine with aura, 28% episodic tension-type headache (ETTH), and 8% chronic TH (CTTH). In 1996, we saw 30% MwoA, 2% MwA, 31% ETTH, and 3% CTH. Migraine shows a lower tendency to remit than TH (28.1% vs 44.4%). MwoA persists in the same form in 43.8% and becomes ETH in 26.3%. ETTH persists in the same form in 26.3% and changes in MwoA in 10.7%. Of headache-free subjects, we recorded a high tendency to remit (34%) and improve (95%); 13 were females (21.7%) and 21 were males (52.5%). The course of headache is not related to age at onset.
  
  
  CONCLUSIONS
  Headache with juvenile onset changes its characteristics over time, with a high tendency to remit (mostly in males) or improve. The implications for pathophysiology and the role of hormonal factors are called into question.
authors.affiliation: Interuniversity Center for the Study of Headaches and Neurotransmitter Disorders, Section of Rome, Italy. v.guidetti@iol.it
authors.forename: V
authors.initials: V
authors.lastname: Guidetti
authors.forename: F
authors.initials: F
authors.lastname: Galli
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000175:diagnosis / Q000628:therapy*; D012727:Sex Characteristics; D018781:Tension-Type Headache / Q000175:diagnosis / Q000628:therapy*; D016896:Treatment Outcome