Nontoxigenic Vibrio cholerae O1 intestinal pathology in adult mice.
The intestinal pathology caused by nontoxigenic Vibrio cholerae O1 was examined in the sealed adult mouse (SAM) model. Histologic examination demonstrated that a nontoxigenic V. cholerae O1 strain that elicited maximum fluid accumulation (FA) in the small intestine of adult mice caused damages to the villi and necrosis of lymphoid elements within solitary submucosal lymphoid nodules in the Peyer's patches. Challenge of mice with a strain that did not elicit intestinal FA produced none of the above tissue responses. Increased FA activity, intestinal alterations, and tissue pathology caused by the nontoxigenic V. cholerae O1 indicate its pathogenic potential.
Moyenuddin
M
M
Georgia State University, Laboratory of Biological Sciences, Atlanta 30202, USA.
Weiss
R
R
Wachsmuth
I K
IK
Ahearn
D G
DG
D000818:Animals; D002771:Cholera / Q000473:pathology*; D004195:Disease Models, Animal; D004487:Edema; D007421:Intestine, Small / Q000473:pathology*; D051379:Mice; D014734:Vibrio cholerae / Q000472:pathogenicity / Q000502:physiology*