Control of gene expression in Plasmodium falciparum.
Transfection has facilitated a functional analysis of transcriptional processes in the human malarial parasite Plasmodium falciparum, providing the first fascinating glimpses into the mechanisms regulating parasite development and pathogenicity. Here we review our rapidly evolving knowledge of what constitutes a promoter, what factors regulate promoter activity and how this activity affects the manifestation of the disease.
Horrocks
P
P
Zentrum für Infektionsforschung, Universität Würzburg, Germany.
Dechering
K
K
Lanzer
M
M
D000818:Animals; D002843:Chromatin / Q000502:physiology; D005786:Gene Expression Regulation; D018507:Gene Expression Regulation, Developmental; D017125:Genes, Protozoan; D006801:Humans; D010963:Plasmodium falciparum / Q000235:genetics* / Q000254:growth & development / Q000472:pathogenicity; D011401:Promoter Regions, Genetic; D015800:Protozoan Proteins / Q000235:genetics
D002843:Chromatin; D015800:Protozoan Proteins; C085731:erythrocyte membrane protein 1, Plasmodium falciparum