First report of Hürthle cell carcinoma revealed by octreotide scanning.
Octreotide is an 8-chain amino acid analog of somatostatin. Somatostatin and its receptors occur naturally in multiple sites within the body and serve a suppressive role in endocrine hormone release. When octreotide, which has a considerably longer half-life than somatostatin, is combined with a radioactive isotope, receptor-based imaging can be performed to visualize tumors with high concentrations of somatostatin receptors. Tumors of neural crest origin -- pituitary adenomas, islet cell tumors, medullary thyroid carcinomas, pheochromocytomas, carcinoids, and paragangliomas -- all express high levels of somatostatin receptors. We present the first reported positive octreotide scan of a Hürthle cell carcinoma of the thyroid and, more important, discuss the role of octreotide scanning in otolaryngology, which has not yet been reviewed by our literature.
Wilson
C J
CJ
Department of Otolaryngology-Head and Neck Surgery, Kansas University Medical Center, Kansas City 66160-7380, USA.
Woodroof
J M
JM
Girod
D A
DA
D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D000368:Aged; D005500:Follow-Up Studies; D006801:Humans; D007205:Indium Radioisotopes; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008854:Microscopy, Electron; D037981:Neck Dissection; D015282:Octreotide; D011877:Radionuclide Imaging; D017481:Receptors, Somatostatin / Q000032:analysis; D013961:Thyroid Gland / Q000000981:diagnostic imaging / Q000473:pathology; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery
D007205:Indium Radioisotopes; D017481:Receptors, Somatostatin; D015282:Octreotide