title: Effect of supplementation with chromium picolinate on antibody titers to 5-hydroxymethyl uracil.
abstract: Recent in vitro studies have shown that chromium (III) compounds such as chromium picolinate, a popular dietary supplement among people trying to lose weight, produce chromosome damage. We monitored levels of DNA damage in a chromium picolinate supplement trial by measuring antibodies titers to an oxidized DNA base, 5-hydroxymethyl-2'-deoxyuridine (HMdU), by enzyme-linked immunosorbent assays. Ten obese volunteer women completed a 8-week course of 400 micrograms chromium picolinate per day. In either absolute titers or percent of the baseline value, there were no changes in antibody titers at 4 or 8 weeks. The titers were very stable within individuals and those of one individual rarely crossed over others, which was reflected in an intraclass correlation coefficient of 0.99 (95% confidence interval: 0.96-1.00). There were no effects on glucose and lipid metabolism in this period. The results of this trial suggest that chromium (III) picolinate in a dose typically used for nutrient supplementation dose not increase oxidative DNA damage, as measured by anti-HMdU antibody levels.
authors.affiliation: Nelson Institute of Environmental Medicine, New York University School of Medicine, New York, USA.
authors.forename: I
authors.initials: I
authors.lastname: Kato
authors.forename: J H
authors.initials: JH
authors.lastname: Vogelman
authors.forename: V
authors.initials: V
authors.lastname: Dilman
authors.forename: J
authors.initials: J
authors.lastname: Karkoszka
authors.forename: K
authors.initials: K
authors.lastname: Frenkel
authors.forename: N P
authors.initials: NP
authors.lastname: Durr
authors.forename: N
authors.initials: N
authors.lastname: Orentreich
authors.forename: P
authors.initials: P
authors.lastname: Toniolo
mesh_terms: D000704:Analysis of Variance; D000917:Antibody Formation / Q000187:drug effects; D016001:Confidence Intervals; D004249:DNA Damage / Q000187:drug effects; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis / Q000187:drug effects*; D007502:Iron Chelating Agents / Q000008:administration & dosage*; D008875:Middle Aged; D009765:Obesity / Q000188:drug therapy* / Q000276:immunology*; D010432:Pentoxyl / Q000031:analogs & derivatives* / Q000276:immunology; D010848:Picolinic Acids / Q000008:administration & dosage* / Q000652:urine; D011446:Prospective Studies
chemical_list: D007075:Immunoglobulin M; D007502:Iron Chelating Agents; D010848:Picolinic Acids; C008055:5-hydroxymethyluracil; D010432:Pentoxyl; C030614:picolinic acid