Effects of S-salbutamol on human isolated bronchus.
A range of stimuli have been used to determine the effect of S-salbutamol on contractile responses of human isolated bronchus. Significant augmentation of contraction was evident during responses to histamine or LTC4 but responses to EFS, methacholine, bradykinin and capsaicin were not influenced and allergic bronchospasm was significantly impaired by prior exposure to S-salbutamol. Since R-salbutamol relaxes human isolated bronchus, the capacity of S-salbutamol to enhance contractile responses to histamine or LTC4 cannot be attributed to activation of beta2-adrenoceptors. It is concluded, therefore, that these effects of S-salbutamol represent distinct pharmacological actions of the distomer. It is also suggested that the capacity of S-salbutamol to augment contraction of airway smooth muscle may contribute to hyperreactivity towards spasmogens when racemic salbutamol is used for symptom relief in asthma and chronic obstructive pulmonary disease (COPD).
Templeton
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AG
Quintiles Scotland Ltd, Research Avenue South, Heriot Watt University Research Park, Edinburgh, Riccarton, EH14 4AP, UK.
Chapman
I D
ID
Chilvers
E R
ER
Morley
J
J
Handley
D A
DA
D000241:Adenosine / Q000378:metabolism; D000420:Albuterol / Q000494:pharmacology*; D001920:Bradykinin / Q000378:metabolism; D001980:Bronchi / Q000187:drug effects* / Q000378:metabolism; D016084:Bronchoconstriction / Q000187:drug effects*; D001993:Bronchodilator Agents / Q000494:pharmacology*; D002211:Capsaicin / Q000378:metabolism; D006632:Histamine / Q000378:metabolism; D006801:Humans; D006967:Hypersensitivity / Q000378:metabolism; D066298:In Vitro Techniques; D017997:Leukotriene C4 / Q000378:metabolism; D016210:Methacholine Chloride / Q000378:metabolism; D010972:Platelet Activating Factor / Q000378:metabolism
D001993:Bronchodilator Agents; D010972:Platelet Activating Factor; D016210:Methacholine Chloride; D017997:Leukotriene C4; D006632:Histamine; D000241:Adenosine; D000420:Albuterol; D002211:Capsaicin; D001920:Bradykinin