title: Effect of LAAM dose on opiate use in opioid-dependent patients. A pilot study.
abstract: The authors conducted a 16-week study with nine opioid-dependent individuals (six male; four white/two African American/three Hispanic; age 36.8 +/- 2.2 years). Participants were assigned to either a low-dose (165 mg/week; n = 5) or high-dose (330 mg/week; n = 4) Levo-alpha-acetylmethadol (LAAM) condition according to a randomized, double-blind, within-subjects crossover design, such that they were inducted onto one maintenance dose for 4 weeks and then were crossed over to receive the converse for 4 weeks. Subsequently, individuals underwent detoxification from LAAM. Eight of nine participants completed the study protocol. The proportion of urine samples positive for opiates was 0.22 +/- 0.08 and 0.53 +/- 0.12, under the high- and low-dose conditions, respectively (F = 11.8; P = 0.01). These results show that LAAM dose regimen affects the degree of abstinence from opioids.
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, West Haven, CT, USA. oliveto.alison_h@west-haven.va.gov
authors.forename: A H
authors.initials: AH
authors.lastname: Oliveto
authors.forename: C
authors.initials: C
authors.lastname: Farren
authors.forename: T R
authors.initials: TR
authors.lastname: Kosten
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008692:Methadyl Acetate / Q000008:administration & dosage / Q000627:therapeutic use*; D009294:Narcotics / Q000008:administration & dosage / Q000627:therapeutic use* / Q000652:urine; D009293:Opioid-Related Disorders / Q000188:drug therapy*; D010865:Pilot Projects; D013375:Substance Withdrawal Syndrome
chemical_list: D009294:Narcotics; D008692:Methadyl Acetate