From the cholinergic gene locus to the cholinergic neuron.
The cholinergic gene locus (CGL) was first identified in 1994 as the site (human chromosome 10q11.2) at which choline acetyltransferase and a functional vesicular acetylcholine transporter are co-localized. Here, we present recent neuroanatomical, developmental, and evolutionary insights into the chemical coding of cholinergic neurotransmission that have been gleaned from the study of the CGL, and its protein products VAChT and ChAT, which comprise a synthesis-sequestration pathway that functionally defines the cholinergic phenotype.
Weihe
E
E
Department of Anatomy and Cell Biology, Philipps University, Marburg, Germany.
Schäfer
M K
MK
Schütz
B
B
Anlauf
M
M
Depboylu
C
C
Brett
C
C
Chen
L
L
Eiden
L E
LE
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism*; D002795:Choline O-Acetyltransferase / Q000235:genetics* / Q000378:metabolism*; D002799:Cholinergic Fibers / Q000502:physiology; D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10; D006801:Humans; D026901:Membrane Transport Proteins; D009474:Neurons / Q000378:metabolism / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology; D050494:Vesicular Acetylcholine Transport Proteins; D033921:Vesicular Transport Proteins
D002352:Carrier Proteins; D026901:Membrane Transport Proteins; C493459:SLC18A3 protein, human; D050494:Vesicular Acetylcholine Transport Proteins; D033921:Vesicular Transport Proteins; D002795:Choline O-Acetyltransferase