Thyroid volume is progressively reduced as a sequela of neck irradiation for childhood Hodgkin's disease.
Thyroid volume reduction was observed, among 25 subjects off-therapy after Hodgkin's disease. The volume reduction was related to dose (p = 0.014) and time from radiotherapy (p = 0.01). The correlation was very specific since all patients with reduced volume had hypothyroidism, but not very sensitive since 25% of subjects with thyroid dysfunction had normal gland volume.
Bossi
G
G
Larizza
D
D
Sommaruga
G
G
Corbella
F
F
Klersy
C
C
Aricò
M
M
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001284:Atrophy; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy / Q000532:radiotherapy*; D006801:Humans; D007037:Hypothyroidism / Q000209:etiology; D007223:Infant; D008297:Male; D009333:Neck / Q000528:radiation effects; D011832:Radiation Injuries / Q000473:pathology*; D011878:Radiotherapy / Q000009:adverse effects*; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000473:pathology* / Q000528:radiation effects