title: Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11.
abstract: Chromosome engineering in mice enables the construction of models of human chromosomal diseases and provides key reagents for genetic studies. To begin to define functional information for a small portion of chromosome 11, deficiencies, duplications, and inversions were constructed in embryonic stem cells with sizes ranging from 1 Mb to 22 cM. Two deficiencies and three duplications were established in the mouse germline. Mice with a 1-Mb duplication developed corneal hyperplasia and thymic tumors, while two different 3- to 4-cM deficiencies were embryonically lethal in heterozygous mice. A duplication corresponding to one of these two deficiencies was able to rescue its haplolethality.
authors.affiliation: Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: P
authors.initials: P
authors.lastname: Liu
authors.forename: H
authors.initials: H
authors.lastname: Zhang
authors.forename: A
authors.initials: A
authors.lastname: McLellan
authors.forename: H
authors.initials: H
authors.lastname: Vogel
authors.forename: A
authors.initials: A
authors.lastname: Bradley
mesh_terms: D000782:Aneuploidy; D000818:Animals; D002875:Chromosomes; D005260:Female; D005313:Fetal Death / Q000235:genetics*; D005819:Genetic Markers; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000235:genetics*; D011247:Pregnancy
chemical_list: D005819:Genetic Markers