title: Significance of a diastolic notch in the uterine artery flow velocity waveform induced by uterine embolisation in the pregnant ewe.
abstract: OBJECTIVE
  To investigate the relation between placental embolisation and the diastolic notch in the uterine artery flow velocity waveform of pregnant ewes under general anaesthesia.
  
  
  METHODS
  Seven pregnant ewes at a gestation 16 to 17 weeks were anaesthesized and microbeads of gelfoam were injected into the uterine artery; changes in the uterine circulation were assessed by Doppler velocimetry.
  
  
  RESULTS
  Gelfoam embolisation reduced uterine blood flow in a dose-dependent manner, from a mean (95%, CI) of 568 mL/min (495-641) to 159 mL/min (131-187) after the injection of 30 mg of gelfoam, and increased the uterine vascular resistance from 135 mmHg x min x L(-1)(103-167) to 498 mmHg x min x L(-1) (422-574). A diastolic notch in uterine artery flow velocity waveform was observed after 20 mg to 25 mg of gelfoam in two ewes and after injection of 30 mg of gelfoam in all seven animals. Injection of 30 mg of gelfoam increased the pulsatility index to 2.4 (1.9-2.9) from 0.6 (0.5-0.7). The mean uterine vascular resistance at the time of the appearance of a diastolic notch was 414 mmHg x min x L(-1)(377-451).
  
  
  CONCLUSIONS
  These findings suggest that an elevated pulsatility index and the presence of a diastolic notch in the uterine artery flow velocity waveform are indicators of increased uterine vascular resistance and impaired uterine circulation.
authors.affiliation: Department of Obstetrics and Gynaecology, Ehime University School of Medicine, Shigenobu, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ochi
authors.forename: K
authors.initials: K
authors.lastname: Matsubara
authors.forename: Y
authors.initials: Y
authors.lastname: Kusanagi
authors.forename: H
authors.initials: H
authors.lastname: Taniguchi
authors.forename: M
authors.initials: M
authors.lastname: Ito
mesh_terms: D000818:Animals; D001158:Arteries / Q000502:physiology; D001783:Blood Flow Velocity; D003971:Diastole; D005260:Female; D017078:Laser-Doppler Flowmetry; D011247:Pregnancy; D011673:Pulsatile Flow; D012756:Sheep; D014599:Uterus / Q000098:blood supply*