title: Effects of Coriolus versicolor polysaccharides peptides on electric activity of mediobasal hypothalamus and on immune function in rats.
abstract: OBJECTIVE
  The nervous mechanism of the immune potentiating effect of Coriolus versicolor polysaccharides peptides (PSP) was studied in Wistar rats.
  
  
  METHODS
  The unit discharge of the mediobasal hypothalamus (MBH) neurons was recorded extracellularly and the lymphocyte proliferation was measured.
  
  
  RESULTS
  PSP 1 g.kg-1 ig for 5 d increased the T-lymphocytes and promoted T-lymphocyte proliferation in spleen and peripheral blood. This promoting effect of PSP was blocked by MBH lesion. PSP increased the discharge frequency of MBH neurons, but no increase in discharge frequency was observed after treatment of PSP plus immune inhibitor, cyclosporin A.
  
  
  CONCLUSIONS
  MBH is involved in the immune-potentiating effect of PSP.
authors.affiliation: Laboratory of Neurobiology, Suzhou Medical College, China.
authors.forename: G D
authors.initials: GD
authors.lastname: Yu
authors.forename: Q Z
authors.initials: QZ
authors.lastname: Yin
authors.forename: Y M
authors.initials: YM
authors.lastname: Hu
authors.forename: Z W
authors.initials: ZW
authors.lastname: Yin
authors.forename: Z L
authors.initials: ZL
authors.lastname: Gu
authors.forename: Z N
authors.initials: ZN
authors.lastname: Qian
authors.forename: Z M
authors.initials: ZM
authors.lastname: Qian
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004594:Electrophysiology; D005260:Female; D007031:Hypothalamus / Q000502:physiology*; D008297:Male; D015213:Neuroimmunomodulation / Q000187:drug effects*; D009474:Neurons / Q000502:physiology; D011124:Polyporaceae / Q000737:chemistry*; D011509:Proteoglycans / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013601:T-Lymphocytes / Q000166:cytology
chemical_list: D000276:Adjuvants, Immunologic; D011509:Proteoglycans; C093216:polysaccharide peptide