Effect of different drugs on end-tidal carbon dioxide during rodent CPR.
The purpose of this study was to investigate the effect of non-adrenergic agents on cardiopulmonary resuscitation (CPR) and end-tidal CO2 (ETCO2) during CPR in a rodent model. Our results suggested that: 1) coronary perfusion pressure (CPP) after drugs infusion was increased significantly by methoxamine, arginine vasopresin (AVP) and angiotension-II (ANG-II), but not by endothelin-1 (ET-1); 2) ETCO2 prior to defibrillation was decreased significantly by a pure alpha 1 adrenergic agents, methoxamine and were increased significantly by non-adrenergic agents, ANG-II and ET-1 during rodent CPR; 3) a significant positive correlation between ETCO2 and CPP was observed in AVP group, suggesting that AVP have little effect on pulmonary circulation; and 4) methoxamine, AVP and ANG-II have similar effect on resuscitability during rodent CPR.
Pan
T
T
Department of Thoracic and Cardiac Surgery, Tongji Hospital, Tongji Medical University, Wuhan.
Zhou
S
S
Studer
W
W
von Planta
M
M
Scheidegger
D
D
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology; D002245:Carbon Dioxide / Q000378:metabolism*; D002302:Cardiac Output / Q000187:drug effects; D016887:Cardiopulmonary Resuscitation; D008297:Male; D008729:Methoxamine / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013990:Tidal Volume / Q000187:drug effects*; D014662:Vasoconstrictor Agents / Q000494:pharmacology
D000316:Adrenergic alpha-Agonists; D014662:Vasoconstrictor Agents; D000804:Angiotensin II; D001127:Arginine Vasopressin; D002245:Carbon Dioxide; D008729:Methoxamine