Signal transduction: fast lane to transcriptional activation.
Two newly reported structures of homodimeric 'STAT' transcription factors bound to DNA reveal at atomic resolution the elegant mechanism through which kinase activity at the cell membrane can be transduced into transcriptional activation within the cell nucleus.
Rhodes
D
D
MRC Laboratory of Molecular Biology Hills Road, Cambridge, CB2 2QH, UK.
Schwabe
J W
JW
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D019281:Dimerization; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D050794:STAT1 Transcription Factor; D050796:STAT3 Transcription Factor; D015398:Signal Transduction / Q000502:physiology*; D015534:Trans-Activators / Q000737:chemistry / Q000378:metabolism*; D014157:Transcription Factors / Q000737:chemistry / Q000378:metabolism; D015533:Transcriptional Activation / Q000502:physiology*
D004268:DNA-Binding Proteins; D050794:STAT1 Transcription Factor; D050796:STAT3 Transcription Factor; D015534:Trans-Activators; D014157:Transcription Factors; D004247:DNA