A review of the role of trials of the use of antibiotics in women with preterm labor and intact membranes.
This updated review addresses the administration of antibiotics in women presenting with preterm labor and intact membranes as well as with bacterial vaginosis. 11 randomized controlled trials dealing with this question have been published since 1986. The results are disappointing. The probable reasons are the small number of patients in the different studies and universal use of antibiotics without performing amniocentesis to isolate the organisms involved.
Chaim
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W
Department of Obstetrics and Gynecology, Soroka Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Maymon
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E
Mazor
M
M
D002821:Chorioamnionitis / Q000517:prevention & control*; D004363:Drug Utilization; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007752:Obstetric Labor, Premature / Q000188:drug therapy*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome; D016585:Vaginosis, Bacterial / Q000188:drug therapy*