title: [Acute and chronic toxicity of saponins from Argania spinosa].
abstract: We evaluated the acute and chronic experimental toxicity of a water extract of saponins from Argania spinosa following oral and intraperitoneal (i.p.) administration in mice (Iops Ofa) and rats (Wistar). The DL50 obtained were 79 mg/kg for the i.p. route and 1,300 mg/kg for the oral route. For the chronic toxicity studies, we administred 100 and 200 mg/kg orally once a day during a 3 month period. There was a decrease in blood sugar in the third month of each therapy. Blood creatinine levels increased, thus evoking a renal pathology. A slight increase in transaminases levels was not significatif. Hematologic parameters were unchanged during the treatment and the histopathologic study showed hepatic glycogen decrease and a focal renal tube deterioration.
authors.affiliation: Laboratoire de Pharmacologie et Toxicologie, Faculté de Médecine et de Pharmacie de Rabat, Rabat Instituts, Agdal, Maroc.
authors.forename: K
authors.initials: K
authors.lastname: Alaoui
authors.forename: M
authors.initials: M
authors.lastname: Belabbes
authors.forename: Y
authors.initials: Y
authors.lastname: Cherrah
authors.forename: M
authors.initials: M
authors.lastname: Hassar
authors.forename: Z
authors.initials: Z
authors.lastname: Charrouf
authors.forename: H
authors.initials: H
authors.lastname: Amarouch
authors.forename: J
authors.initials: J
authors.lastname: Roquebert
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002240:Carbohydrate Sequence; D004334:Drug Administration Schedule; D005260:Female; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D015394:Molecular Structure; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000008:administration & dosage / Q000633:toxicity*; D014197:Trees
chemical_list: D012503:Saponins