title: [Secondary osteosarcoma (in a dog) after bone fracture healed on the secondary type].
abstract: A case is reported of osteosarcoma arising in a dog after the fracture of the femur. The tumor was diagnosed 6 years after the trauma. We suppose that the cause of malignant transformation in this case was a permanent mechanical trauma, restructuration and regeneration of the bone. This mechanism, possibly, also may take place in the genesis of primary osteosarcomas.
authors.affiliation: N. N. Blokhin Cancer Research Center, Moscow.
authors.forename: Iu N
authors.initials: IuN
authors.lastname: Solov'ev
authors.forename: V N
authors.initials: VN
authors.lastname: Mitin
authors.forename: D V
authors.initials: DV
authors.lastname: Garanin
authors.forename: V I
authors.initials: VI
authors.lastname: Frolov
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D001862:Bone Resorption; D004285:Dogs; D005264:Femoral Fractures / Q000150:complications*; D005269:Femur / Q000473:pathology*; D008297:Male; D012516:Osteosarcoma / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D013997:Time Factors