Effect of chronic haloperidol treatment on synaptic protein mRNAs in the rat brain.
Chronic haloperidol treatment caused significant decreases in the levels of synaptotagmin I and IV, synaptobrevin II, syntaxin 1A and Rab 3A mRNAs in the nucleus accumbens but not in the prefrontal cortex medial field, striatum, substantia nigra and ventral tegmental area. No significant changes in SNAP 25 and synaptophysin mRNA levels were observed in any brain region examined. The reduced expression of synaptic proteins may be related to haloperidol-induced depolarization block of mesolimbic dopamine neurons.
Nakahara
T
T
Department of Chemistry, Faculty of Science, Kyushu University, Ropponmatsu, Fukuoka 810-8560, Japan. nakahara@rc.kyushu-u.ac.jp
Nakamura
K
K
Tsutsumi
T
T
Hashimoto
K
K
Hondo
H
H
Hisatomi
S
S
Motomura
K
K
Uchimura
H
H
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D002135:Calcium-Binding Proteins; D003342:Corpus Striatum / Q000737:chemistry; D006220:Haloperidol / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics; D009714:Nucleus Accumbens / Q000737:chemistry; D012333:RNA, Messenger / Q000032:analysis / Q000096:biosynthesis / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013569:Synapses / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D050863:Synaptotagmin I; D050857:Synaptotagmins; D013995:Time
D002135:Calcium-Binding Proteins; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D050863:Synaptotagmin I; C494312:Syt1 protein, rat; D050857:Synaptotagmins; D006220:Haloperidol