Strategies for tolerance induction in nonhuman primates.
Organ transplants in nonhuman primates provide a model which closely simulates the biological conditions of human organ transplantation, due to similarities between human and primate MHC (class I and II) structure and expression. Several strategies for tolerance induction have been developed in nonhuman primate models. These include targeting the T cell receptor or costimulatory molecules and the generation of mixed chimerism. Tolerance can be reliably induced in several such models, although none with 100% success.
Hamawy
M M
MM
Department of Surgery, University of Wisconsin-Madison Medical School, H4/784 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792,USA. hamawy@surgery.wisc.edu
Knechtle
S J
SJ
D000818:Animals; D016026:Bone Marrow Transplantation; D002678:Chimera; D006085:Graft Survival; D000882:Haplorhini; D006801:Humans; D007165:Immunosuppression Therapy; D000922:Immunotoxins / Q000494:pharmacology
D000922:Immunotoxins