Microglial activation in multiple system atrophy: a potential role for NF-kappaB/rel proteins.
Microglial activation is a prominent feature of affected brain areas in multiple system atrophy. Microglia express proinflammatory peptides, which may be a result of activation of nuclear factor-KB. We investigated the nuclear presence of RelA, the 65 kDa subunit of the NF-KB/RelA family in striatum and brain stem of patients with multiple system atrophy. Affected brain areas of patients with multiple system atrophy showed a marked immunoreactivity for nuclear Rel A p65, which was almost exclusively localized in activated microglia. Interestingly nuclear translocation of Rel A was not detected in striatal tissue of controls and Parkinson disease patients. Thus, NF-kappaB/Rel A complexes may play a role in mediating microglial activation in multiple system atrophy.
Schwarz
S C
SC
Department of Neurology, University of Ulm, Germany.
Seufferlein
T
T
Liptay
S
S
Schmid
R M
RM
Kasischke
K
K
Foster
O J
OJ
Daniel
S
S
Schwarz
J
J
D000368:Aged; D001933:Brain Stem / Q000737:chemistry / Q000473:pathology; D002467:Cell Nucleus / Q000737:chemistry; D003342:Corpus Striatum / Q000737:chemistry / Q000473:pathology; D003593:Cytoplasm / Q000737:chemistry; D006801:Humans; D007150:Immunohistochemistry; D016177:Macrophage-1 Antigen / Q000032:analysis; D017628:Microglia / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000378:metabolism* / Q000473:pathology; D016328:NF-kappa B / Q000032:analysis / Q000502:physiology*; D051996:Transcription Factor RelA
D016177:Macrophage-1 Antigen; D016328:NF-kappa B; D051996:Transcription Factor RelA