Transcranial magnetic stimulation in mania: a controlled study.
OBJECTIVE
Left prefrontal transcranial magnetic stimulation has been reported to have ECT-like effects in depression; therefore, the authors planned a study of transcranial magnetic stimulation in mania.


METHODS
Sixteen patients completed a 14-day double-blind, controlled trial of right versus left prefrontal transcranial magnetic stimulation at 20 Hz (2-second duration per train, 20 trains/day for 10 treatment days). Mania was evaluated with the Mania Scale, the Brief Psychiatric Rating Scale, and the Clinical Global Impression.


RESULTS
Significantly more improvement was observed in patients treated with right than with left prefrontal transcranial magnetic stimulation.


CONCLUSIONS
The therapeutic effect of transcranial magnetic stimulation in mania may show laterality opposite to its effect in depression.
Grisaru
N
N
Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel.
Chudakov
B
B
Yaroslavsky
Y
Y
Belmaker
R H
RH
D000328:Adult; D001714:Bipolar Disorder / Q000175:diagnosis / Q000523:psychology / Q000628:therapy*; D010054:Brief Psychiatric Rating Scale / Q000706:statistics & numerical data; D003866:Depressive Disorder / Q000628:therapy; D004311:Double-Blind Method; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017397:Prefrontal Cortex / Q000502:physiology*; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D050781:Transcranial Magnetic Stimulation / Q000627:therapeutic use*; D016896:Treatment Outcome