Psoriasis as a T cell-mediated autoimmune disease.
Psoriasis is a common chronic skin disease in which T lymphocytes are thought to play a vital pathogenic role. Evidence shows that these are activated memory skin-homing T cells which induce characteristic disease features via cytokine production. Understanding the mechanisms of T cell accumulation in skin and mediation of psoriasis is critical to designing immunotherapy for this distressing disease.
Barker
J N
JN
Therapy Research Unit, St John's Institute of Dermatology, St Thomas' Hospital, London.
D001327:Autoimmune Diseases / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007167:Immunotherapy; D008213:Lymphocyte Activation; D011565:Psoriasis / Q000276:immunology* / Q000628:therapy; D016201:Receptors, Lymphocyte Homing / Q000276:immunology; D012867:Skin / Q000276:immunology*; D013290:Streptococcal Infections / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology
D016201:Receptors, Lymphocyte Homing