[Involvement of nucleus amygdaloideus centralis, lateral hypothalamus/perifornical region and nucleus paraventricularis in insular cortex-pressor response].
In urethane-anesthetized, tubocurarine-immobilized and artificially ventilated rats, glutamate (Glu) injection into the insular cortex (INS) and substance P injection into the lateral hypothalamus-perifornical region (LH/PF) or nucleus paraventricularis (NPV) caused pressor responses. Preinjection of procaine or glutamate diethyl ester (GDEE, a glutamate antagonist) bilaterally into the nucleus amygdaloideus centralis (AC) and [D-Pro2, D-Phe7, D-Trp9]-substance P (DPDPDT, a substance P antagonist), but not GDEE, into the LH/PF markedly attenuated the pressor response induced by glutamate injection into the INS. Procaine or DPDPDT preinjection into the NPV also reduced the INS-pressor response. Since the LH/PF and NPV were found to mediate the AC-pressor response, the above results suggest that the INS-pressor response is the final outcome of activation of AC (Glu-receptor)-LH/PF and NPV (SP receptor) system.
Gu
Y H
YH
Department of Physiology, Beijing Medical University.
Xu
W K
WK
Lu
Y C
YC
Wang
Y G
YG
Tan
L
L
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001794:Blood Pressure; D002540:Cerebral Cortex / Q000502:physiology*; D018698:Glutamic Acid / Q000494:pharmacology; D007031:Hypothalamus / Q000502:physiology*; D008297:Male; D010286:Paraventricular Hypothalamic Nucleus / Q000502:physiology*; D011311:Pressoreceptors / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013373:Substance P / Q000494:pharmacology*
D013373:Substance P; D018698:Glutamic Acid