title: Anodic voltammetry of cefotaxime.
abstract: In this study electrooxidation of cefotaxime was investigated using specially activated glassy carbon (GC), platinum and carbon paste (CP) electrodes in different supporting electrolyte solutions and at different pHs. The data revealed that the shapes of the voltammograms and the numbers of the oxidation steps changed depending on the nature of the electrode. The nature of the supporting electrolyte was also important for the response of the electrode. From an analytical point of view, the activated GC electrode was the most favourable one. In 0.2 M H3PO4 with an activated GC electrode the calibration graph gave two lines with different slopes in the concentration ranges of 2 x 10(-5)-1 x 10(-4) and 2 x 10(-4)-6 x 10(-4). The results of the recovery test and statistical analysis showed that the voltammetric method could be used for the determination of cefotaxime.
authors.affiliation: Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University, Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Yilmaz
authors.forename: I
authors.initials: I
authors.lastname: Biryol
mesh_terms: D002439:Cefotaxime / Q000737:chemistry*; D002511:Cephalosporins / Q000737:chemistry*; D002623:Chemistry Techniques, Analytical; D004563:Electrochemistry / Q000379:methods*; D004566:Electrodes; D006863:Hydrogen-Ion Concentration; D012044:Regression Analysis; D015203:Reproducibility of Results
chemical_list: D002511:Cephalosporins; D002439:Cefotaxime