title: Superoxide dismutases in relation to the overall survival of colorectal cancer patients.
abstract: Reactive oxygen metabolites are implicated in the initiation and promotion of cancer. In addition, oxidant scavengers, such as manganese--(Mn-SOD) and copper/zinc--superoxide dismutase (Cu/Zn-SOD), are thought to contribute to colorectal cancer treatment response. In the present study, the prognostic significance of the Mn- and Cu/Zn-SOD antigen content of normal mucosa and carcinomas of 163 patients with colorectal cancer was evaluated in comparison with major clinicopathological parameters, with respect to the 5-year overall survival. The Mn-SOD content of carcinomas was found to be significantly higher than that of normal mucosa, whereas there was no difference in the Cu/Zn-SOD content between the normal mucosa and carcinomas. No association was demonstrable between the Mn-SOD and Cu/Zn-SOD content of the tissues and the assessed clinicopathological parameters (gender, age, localization, differentiation grade, diameter and Dukes' stage), with the exception of the Cu/Zn-SOD and the differentiation grade of the carcinomas. Univariate analysis showed that a high Mn-SOD content of carcinomas was associated with a poor 5-year overall survival of the patients with colorectal cancer. Multivariate analysis including all clinicopathological parameters revealed that this Mn-SOD parameter was prognostically independent. The Mn- and Cu/Zn-SOD content of normal mucosa and the Cu/Zn-SOD content of carcinomas were not associated with the overall survival of the patients. In conclusion, this study demonstrates that for patients with colorectal cancer the Mn-SOD content of colorectal carcinomas has a significant prognostic value that is independent from major clinicopathological parameters, including Dukes' stage.
authors.affiliation: Department of Gastroenterology and Hepatology, Leiden University Medical Center, The Netherlands.
authors.forename: A M
authors.initials: AM
authors.lastname: Janssen
authors.forename: C B
authors.initials: CB
authors.lastname: Bosman
authors.forename: C F
authors.initials: CF
authors.lastname: Sier
authors.forename: G
authors.initials: G
authors.lastname: Griffioen
authors.forename: F J
authors.initials: FJ
authors.lastname: Kubben
authors.forename: C B
authors.initials: CB
authors.lastname: Lamers
authors.forename: J H
authors.initials: JH
authors.lastname: van Krieken
authors.forename: C J
authors.initials: CJ
authors.lastname: van de Velde
authors.forename: H W
authors.initials: HW
authors.lastname: Verspaget
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000201:enzymology*; D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000401:mortality*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000201:enzymology*; D008297:Male; D015999:Multivariate Analysis; D011379:Prognosis; D013482:Superoxide Dismutase / Q000378:metabolism*
chemical_list: D013482:Superoxide Dismutase