Comparison of different animal models of stress reveals a non-monotonic effect.
A handling-only control and two footshocked stressed groups for which the numbers of footshocks, 10 or 100, were determined by different proposed clinically relevant models were compared after a 15-day delay on the alerting-immobility response to a sudden reduction in noise. Only the 10-shocks group showed a significantly increased level of alert-immobility. The implications of this non-monotonicity of effects of increasing stress for modelling and scientific practice are considered.
Murison
R
R
Dept. of Biological & Medical Psychology, University of Bergen Arstadveien 21 N-5009 Bergen, Norway. murison@psych.uib.no
Overmier
J B
JB
D000818:Animals; D004597:Electroshock; D006234:Handling, Psychological; D006380:Helplessness, Learned; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012149:Restraint, Physical; D013045:Species Specificity; D013315:Stress, Psychological / Q000503:physiopathology* / Q000523:psychology