Neural substrate of nicotine addiction as defined by functional brain maps of gene expression.
The distributed neural networks involved in the intravenous self-administration of nicotine and cocaine, and in a model of relapse of nicotine-taking after abstinence, were compared in Wistar rats. Post-mortem brain maps of c-fos-related antigens expression showed specific activation in prefrontal cortex, anterior cingulate and nucleus accumbens for both drugs, but of the anterior cingulate cortex only during relapse, suggesting that a subset of the neural network involved in drug self-administration is activated during relapse.
Pich
E M
EM
Glaxo Wellcome SpA, Verona, Italy.
Chiamulera
C
C
Tessari
M
M
D000818:Animals; D001931:Brain Mapping / Q000379:methods*; D002540:Cerebral Cortex / Q000378:metabolism / Q000502:physiology; D003042:Cocaine / Q000008:administration & dosage; D004298:Dopamine / Q000502:physiology; D018765:Dopamine Uptake Inhibitors / Q000008:administration & dosage; D005786:Gene Expression Regulation / Q000502:physiology*; D007150:Immunohistochemistry; D008032:Limbic System / Q000378:metabolism / Q000502:physiology; D009415:Nerve Net / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics*; D051381:Rats; D017208:Rats, Wistar; D012646:Self Administration; D014029:Tobacco Use Disorder / Q000503:physiopathology*
D018765:Dopamine Uptake Inhibitors; D009419:Nerve Tissue Proteins; D016760:Proto-Oncogene Proteins c-fos; D003042:Cocaine; D004298:Dopamine