title: Results of chronic animal experiments with a new version of a magnetically suspended centrifugal pump.
abstract: We have developed a magnetically suspended centrifugal pump (MSCP) for long-term ventricular support. This study reports results of chronic animal experiments using a new version of the MSCP. Three sheep weighing 50-70 kg were used in this study. A left heart assist system was established with cannulas into the descending aorta and the left ventricular apex. In two sheep the MSCP was positioned outside the body and in one sheep implanted on the chest wall. The pumping flow was estimated by the motor current and motor speed. The temperature of the pump and the muscle near the pump was recorded for 10 days after operation. The duration of continuous pumping was 60, 140, and 230 days+ (ongoing), respectively. The cause of termination was infection associated with thrombus formation in the first, and failure of magnetic suspension in the second sheep. No thrombus or embolus was observed after sacrifice of the second sheep. The third sheep has been going well despite skin necrosis around the pump pocket. The estimation of pumping flow was reliable even at 140 days. Temperature of the pump surface was 42 degrees C immediately after the operation and gradually reduced to 41 degrees C. The MSCP is a reliable pump for long-term circulatory assist.
authors.affiliation: Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nishimura
authors.forename: S
authors.initials: S
authors.lastname: Kono
authors.forename: T
authors.initials: T
authors.lastname: Nishina
authors.forename: T
authors.initials: T
authors.lastname: Akamatsu
authors.forename: T
authors.initials: T
authors.lastname: Tsukiya
authors.forename: C
authors.initials: C
authors.lastname: Nojiri
authors.forename: T
authors.initials: T
authors.lastname: Ozaki
authors.forename: M
authors.initials: M
authors.lastname: Komeda
mesh_terms: D000818:Animals; D006353:Heart-Assist Devices; D008280:Magnetics; D012756:Sheep