title: In vitro activity of a new polyene, SPA-S-843, against yeasts.
abstract: The in vitro activity of a new water-soluble polyene, SPA-S-843, was evaluated against 116 strains of Candida, Cryptococcus, and Saccharomyces spp. and compared with that of amphotericin B. SPA-S-843 demonstrated better inhibitory activity against all of the yeasts examined and better fungicidal activity against Candida albicans, Candida glabrata, Candida krusei, and Candida tropicalis than did amphotericin B.
authors.affiliation: Research Laboratories, Società Prodotti Antibiotici SpA, 20143 Milan, Italy. dm@apm.it
authors.forename: C
authors.initials: C
authors.lastname: Rimaroli
authors.forename: T
authors.initials: T
authors.lastname: Bruzzese
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D003454:Cryptococcus / Q000187:drug effects; D011090:Polyenes / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D015003:Yeasts / Q000187:drug effects*
chemical_list: D000935:Antifungal Agents; D011090:Polyenes; C115650:SPA S 843; D000666:Amphotericin B