title: Role of neurotrophic factors in motoneuron development.
abstract: More than 10 factors from different gene families are now known to enhance motoneuron survival, and to be expressed in a manner consistent with a role in regulating motoneuron numbers during development. We provide evidence that: a) different factors may act on different sub-populations of motoneurons; b) different factors may act in synergy on a given motoneuron. Thus, the functional diversity of motoneurons, and the cellular complexity of their environment, may be reflected in the mechanisms that have evolved to keep them alive.
authors.affiliation: INSERM U382, IBDM (CNRS-INSERM-Univ. Méditerranée-AP Marseille), France.
authors.forename: C E
authors.initials: CE
authors.lastname: Henderson
authors.forename: Y
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: J
authors.initials: J
authors.lastname: Livet
authors.forename: V
authors.initials: V
authors.lastname: Arce
authors.forename: A
authors.initials: A
authors.lastname: Garces
authors.forename: O
authors.initials: O
authors.lastname: deLapeyrière
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000502:physiology; D009046:Motor Neurons / Q000502:physiology*; D005810:Multigene Family; D009414:Nerve Growth Factors / Q000235:genetics / Q000502:physiology*
chemical_list: D009414:Nerve Growth Factors