[Immunohistochemical study of neoplasm-associated proteins in cerebellum medulloblastomas].
Tumor-associated proteins are studied immunohistochemically in 86 medulloblastomas (MB). Three main variants of their coexpression (70% of all cases studied) are distinguished. The 1st variant (24 cases): expression of Rb and nm23 proteins and the lack of tenascin expression. The 2nd variant (25 cases): tenascin expression and lack of Rb and nm23 expression. The 3rd variant (12 cases): the expression of tenascin, Rb, p53 and/or bc12. Tenascin-positive MB much more frequently expressed oncoproteins p53, bc12, c-erb B-2 and p30/32, and had higher indices of "growth fraction". Tenascin immunoreactivity and that of other oncoproteins prevailed in MB with desmoplasia and in tumors with immunohistochemical features of neuronal differentiation.
Korshunov
A G
AG
N. N. Burdenko Research Institute of Neurosurgery, Moscow.
Sycheva
R V
RV
Golanov
A V
AV
D000293:Adolescent; D000328:Adult; D014408:Biomarkers, Tumor; D002528:Cerebellar Neoplasms / Q000378:metabolism* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000378:metabolism* / Q000473:pathology; D020559:Monomeric GTP-Binding Proteins; D054778:NM23 Nucleoside Diphosphate Kinases; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D009701:Nucleoside-Diphosphate Kinase; D016160:Retinoblastoma Protein / Q000096:biosynthesis; D019063:Tenascin / Q000096:biosynthesis; D014157:Transcription Factors / Q000096:biosynthesis
D014408:Biomarkers, Tumor; D054778:NM23 Nucleoside Diphosphate Kinases; D009363:Neoplasm Proteins; D016160:Retinoblastoma Protein; D019063:Tenascin; D014157:Transcription Factors; C517938:NME1 protein, human; D009701:Nucleoside-Diphosphate Kinase; D020559:Monomeric GTP-Binding Proteins