Estradiol prevents kainic acid-induced neuronal loss in the rat dentate gyrus.
The neuroprotective role of 17beta-estradiol in the hippocampal dentate gyrus of adult rats treated with kainic acid has been investigated. The systemic injection of a single low dose (7 mg/kg) of kainic acid to ovariectomized rats produced a marked loss of Nissl-stained and somatostatin-immunoreactive hilar neurons. A single simultaneous systemic dose of estradiol (150 microg per animal) prevented the kainic acid-induced decrease in Nissl-stained and somatostatinergic hilar neurons. These results indicate that estradiol may protect adult hilar neurons in vivo from neurotoxic-induced cell death.
Azcoitia
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Departamento de Biología Celular, Facultad Biología, Universidad Complutense, Madrid, Spain.
Sierra
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Garcia-Segura
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LM
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D018891:Dentate Gyrus / Q000166:cytology / Q000187:drug effects*; D004958:Estradiol / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D007150:Immunohistochemistry; D007274:Injections, Intraperitoneal; D007608:Kainic Acid / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D009474:Neurons / Q000166:cytology / Q000187:drug effects*; D018696:Neuroprotective Agents; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar; D013004:Somatostatin / Q000032:analysis
D018696:Neuroprotective Agents; D004958:Estradiol; D013004:Somatostatin; D007608:Kainic Acid