title: Effect of body posture on spirometric values and upper airway obstruction indices derived from the flow-volume loop in young nonobese subjects.
abstract: OBJECTIVE
  To define the effect of changes in body posture on flow-volume loops (FVLs) and four commonly used indices of upper airway obstruction (UAO) in young, nonobese normal subjects.
  
  
  METHODS
  Prospective comparative study.
  
  
  METHODS
  Pulmonary function laboratory at an academic hospital.
  
  
  METHODS
  Thirty-one normal volunteers.
  
  
  METHODS
  At least three FVLs per posture were obtained in the sitting, supine, and left and right lateral recumbent postures while maintaining a constant position of the head and neck in relation to the trunk. In each body posture, the largest observed flow rates were used to calculate the UAO indices.
  
  
  RESULTS
  When subjects changed from the sitting to each of the three recumbent postures, all spirometric values decreased significantly (p<0.0001). However, among the four UAO indices, only the FEV1/peak expiratory flow ratio increased significantly (although only slightly, by 2.9 and 4.4%, respectively) in both the right and left lateral recumbent postures (p<0.0001), but not in the supine posture. None of the subjects developed an inspiratory or expiratory plateau on the FVL in any of the three recumbent postures.
  
  
  CONCLUSIONS
  In young, nonobese normal subjects, recumbency does not induce UAO, at least not detectable by changes in the FVL configuration or in UAO indices derived from the FVL. Furthermore, the study provides the upper limits of recumbency-related changes in the various UAO indices for young, nonobese normal subjects.
authors.affiliation: Department of Medicine, Academic Hospital, University of Brussels (AZ-VUB), Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Meysman
authors.forename: W
authors.initials: W
authors.lastname: Vincken
mesh_terms: D000328:Adult; D000402:Airway Obstruction / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007320:Inspiratory Capacity; D008297:Male; D009055:Mouth / Q000502:physiology; D010366:Peak Expiratory Flow Rate; D011187:Posture / Q000502:physiology*; D011312:Pressure; D011446:Prospective Studies; D012016:Reference Values; D013147:Spirometry