title: A spherical dose model for radiosurgery plan optimization.
abstract: Conventional 3D dose calculations for stereotactic radiosurgery involve integration of individual static beams comprising a set of arcs. For iterative optimization of multiple isocentre treatment, which requires repetitive dose calculations at a large number of sample points, the conventional method is too slow. To overcome this problem spherically symmetric dose distributions are assumed. The authors describe a spherical dose model derived from a parametrized convolution of the collimator width and a dose spread kernel. The method is fast and easy to implement requiring just a single empirically derived value. Furthermore, the model is differentiable with respect to the parameters to be optimized. This property is useful when the optimization strategies rely on gradient information.
authors.affiliation: Department of Radiation Oncology, University of Washington, Seattle 98195-6043, USA.
authors.forename: P S
authors.initials: PS
authors.lastname: Cho
authors.forename: H G
authors.initials: HG
authors.lastname: Kuterdem
authors.forename: R J
authors.initials: RJ
authors.lastname: Marks
mesh_terms: D008962:Models, Theoretical; D011874:Radiometry; D016634:Radiosurgery; D013238:Stereotaxic Techniques