Identification of a fission yeast dynamin-related protein involved in mitochondrial DNA maintenance.
Members of the dynamin-related proteins family have been identified in a wide range of organisms, however their precise functions remain elusive. We have identified a new member of that GTPase family in the fission yeast Schizosaccharomyces pombe. We show that Msp1+ is an essential nuclear gene encoding a 101 kDa protein whose closest homologue is the S. cerevisiae MGM1 gene product. We also report that msp1 conditional loss of function affects the maintenance of mitochondrial DNA and leads to growth arrest associated with respiratory deficiency.
Pelloquin
L
L
Institut de Pharmacologie et de Biologie Structurale du CNRS, Université Paul Sabatier, 205, route de Narbonne, Toulouse cedex, 31077, France.
Belenguer
P
P
Menon
Y
Y
Ducommun
B
B
D000251:Adenosine Triphosphatases / Q000145:classification / Q000235:genetics*; D000595:Amino Acid Sequence; D004272:DNA, Mitochondrial / Q000378:metabolism*; D034281:Dynamins; D005656:Fungal Proteins / Q000145:classification / Q000235:genetics*; D020558:GTP Phosphohydrolases / Q000235:genetics; D019204:GTP-Binding Proteins; D020043:Genes, Essential; D005800:Genes, Fungal; D008928:Mitochondria / Q000502:physiology*; D024101:Mitochondrial Proteins; D008969:Molecular Sequence Data; D016296:Mutagenesis; D029701:Saccharomyces cerevisiae Proteins; D012568:Schizosaccharomyces / Q000502:physiology*; D029702:Schizosaccharomyces pombe Proteins; D017386:Sequence Homology, Amino Acid
D004272:DNA, Mitochondrial; D005656:Fungal Proteins; C082883:MGM1 protein, S cerevisiae; D024101:Mitochondrial Proteins; D029701:Saccharomyces cerevisiae Proteins; D029702:Schizosaccharomyces pombe Proteins; D000251:Adenosine Triphosphatases; D020558:GTP Phosphohydrolases; D019204:GTP-Binding Proteins; D034281:Dynamins; C498344:Msp1 protein, S pombe