title: Myelodysplastic syndrome with hypereosinophilia and a nonrandom chromosomal abnormality dic(1;7): confirmation of eosinophil clonal involvement by fluorescence in situ hybridization.
abstract: We report a case of de novo myelodysplastic syndrome (MDS) with hypereosinophilia and dic(1;7) in which eosinophil clonal involvement was confirmed by fluorescence in situ hybridization. There have been two previous reports in the literature of eosinophilic MDS with dic(1;7) or t(1;7) in which eosinophil clonality was demonstrated. The specific breakpoints on chromosomes 1 and 7 differ in the three cases, making it difficult to implicate disruption of a single gene as causative; nevertheless, the nonrandom occurrence of t(1;7) or dic(1;7) with malignant eosinophilic proliferations suggests that this chromosomal rearrangement is involved in the etiology of the disease.
authors.affiliation: Leukemia/Bone Marrow Transplantation Program of British Columbia, Vancouver General Hospital, Canada.
authors.forename: D L
authors.initials: DL
authors.lastname: Forrest
authors.forename: D E
authors.initials: DE
authors.lastname: Horsman
authors.forename: C L
authors.initials: CL
authors.lastname: Jensen
authors.forename: B R
authors.initials: BR
authors.lastname: Berry
authors.forename: B I
authors.initials: BI
authors.lastname: Dalal
authors.forename: M J
authors.initials: MJ
authors.lastname: Barnett
authors.forename: S H
authors.initials: SH
authors.lastname: Nantel
mesh_terms: D000368:Aged; D000753:Anemia, Refractory / Q000150:complications / Q000235:genetics*; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics*; D017809:Fatal Outcome; D005819:Genetic Markers; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000150:complications / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic
chemical_list: D005819:Genetic Markers