[Effect of hemin in treating hemorrhagic anemia and toxicity].
OBJECTIVE
To study the effect of hemin in treating hemorrhagic anemia and toxicity.


METHODS
Fifty rats with hemorrhagic anemia were randomly divided into 5 groups with different dosage of hemin (93, 168, 300 mg.kg-1.d-1), ferrous gluconate (FG 300 mg.kg-1.d-1), and water, ig for 7 d. Twenty mice fed with hemin (6.0 g.kg-1.d-1) in 24 h for observing acute toxicity effects. Long-term toxicity were observed in 80 rats given hemin (0.65, 1.3, 2.6 g.kg-1.d-1) in 3 months.


RESULTS
Hb of the rats of corresponding groups were 66-->121, 71-->141, 66-->148, 69-->140, and 67-->112 g.L-1. There were no adverse effects observed on acute toxicity test. No abnormalitis were found in hemogram, liver renal function test, and autopsy.


CONCLUSIONS
Hemin had a better effect than FG and no adverse effect was found in hemin.
You
K S
KS
Department of Pharmacology, Fujian Medical College, Fuzhou, China.
Wu
B
B
Huang
Z Q
ZQ
Zhang
C
C
Pan
L J
LJ
Wu
G T
GT
Zhao
Z Q
ZQ
Huang
M H
MH
D018798:Anemia, Iron-Deficiency / Q000188:drug therapy* / Q000209:etiology; D000818:Animals; D005260:Female; D005296:Ferrous Compounds / Q000627:therapeutic use; D006427:Hemin / Q000627:therapeutic use* / Q000633:toxicity; D006470:Hemorrhage / Q000150:complications; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D005296:Ferrous Compounds; D006427:Hemin; C011819:ferrous gluconate