HIV-1 gag proteins: diverse functions in the virus life cycle.
The Gag proteins of HIV-1, like those of other retroviruses, are necessary and sufficient for the assembly of virus-like particles. The roles played by HIV-1 Gag proteins during the life cycle are numerous and complex, involving not only assembly but also virion maturation after particle release and early postentry steps in virus replication. As the individual Gag domains carry out their diverse functions, they must engage in interactions with themselves, other Gag proteins, other viral proteins, lipid, nucleic acid (DNA and RNA), and host cell proteins. This review briefly summarizes our current understanding of how HIV-1 Gag proteins function in the virus life cycle.
Freed
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National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892-0460, USA. EFreed@nih.gov
D000595:Amino Acid Sequence; D019380:Anti-HIV Agents / Q000494:pharmacology; D002213:Capsid / Q000378:metabolism; D015686:Gene Products, env / Q000378:metabolism; D015683:Gene Products, gag / Q000378:metabolism / Q000502:physiology*; D015488:HIV Antigens / Q000378:metabolism; D015497:HIV-1 / Q000254:growth & development / Q000502:physiology*; D008969:Molecular Sequence Data; D019251:Nucleocapsid / Q000378:metabolism; D014158:Transcription, Genetic; D014764:Viral Proteins; D019065:Virus Assembly; D054301:gag Gene Products, Human Immunodeficiency Virus
D019380:Anti-HIV Agents; D015686:Gene Products, env; D015683:Gene Products, gag; D015488:HIV Antigens; D014764:Viral Proteins; D054301:gag Gene Products, Human Immunodeficiency Virus; C054858:p17 protein, Human Immunodeficiency Virus Type 1