title: Distribution of HLA class II alleles among Spanish patients with pemphigus vulgaris.
abstract: Twenty-six unrelated Spanish Caucasian individuals affected by pemphigus vulgaris (PV) were HLA typed and frequencies compared with those of 200 ethnically matched healthy controls. Twenty-three out of 26 patients were HLA-DR4. The frequency of HLA-DR14 was also increased (31%; controls: 4%). Of the 23 patients positive for HLA-DR4, 21 carried the DRB1*0402 allele. Therefore, the frequency of HLA-DRB1*0402 among patients was 81% (4% in controls; P=4.7x10(-27), OR=100.8). Interestingly, HLA-DR13, a frequent HLA-DR specificity in the Spanish general population (27%), was absent among the PV patients (P=0.009; Pc=0.1; OR=0.05). Taking together these data, we can conclude that, in the Spanish population, PV is preferentially and strongly associated with HLA-DRB1*0402, whereas DRB1*13 seems to confer a protective effect in our population.
authors.affiliation: Servicio de Immunología and Unidad de Dermatología, Hospital Universitario Virgen del Rocío, Servicio Andaluz de Salud, Sevilla, Spain.
authors.forename: M F
authors.initials: MF
authors.lastname: González-Escribano
authors.forename: G
authors.initials: G
authors.lastname: Jiménez
authors.forename: K
authors.initials: K
authors.lastname: Walter
authors.forename: M
authors.initials: M
authors.lastname: Montes
authors.forename: A M
authors.initials: AM
authors.lastname: Perez-Bernal
authors.forename: M R
authors.initials: MR
authors.lastname: Rodríguez
authors.forename: J S
authors.initials: JS
authors.lastname: Conejo-Mir
authors.forename: A
authors.initials: A
authors.lastname: Núñez-Roldán
mesh_terms: D000483:Alleles; D004247:DNA / Q000097:blood; D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006680:HLA Antigens / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D010392:Pemphigus / Q000235:genetics* / Q000276:immunology*; D013030:Spain / Q000453:epidemiology; D044465:White People / Q000235:genetics*
chemical_list: D006680:HLA Antigens; D000949:Histocompatibility Antigens Class II; D004247:DNA