RNA trafficking in myelinating cells.
In the past year, several key molecular components of the RNA trafficking pathway in myelinating cells have been identified: distinct cis-acting elements for RNA transport and localization have been characterized in myelin basic protein mRNA; hnRNP A2 has been identified as a trans-acting factor in oligodendrocytes that binds specifically to the RNA transport sequence; and microtubules and kinesin have been identified as cytoskeletal elements required for RNA transport in oligodendrocytes.
Carson
J H
JH
Department of Biochemistry, University of Connecticut Health Center, Farmington 06030, USA. jcarson@nso2.uchc.edu
Kwon
S
S
Barbarese
E
E
D000818:Animals; D001692:Biological Transport / Q000502:physiology; D009186:Myelin Sheath / Q000378:metabolism*; D009836:Oligodendroglia / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism*
D012333:RNA, Messenger