title: Pharyngeal swallowing disorders: selection for and outcome after myotomy.
abstract: OBJECTIVE
  To develop selection criteria based on the mechanical properties of pharyngoesophageal swallowing that indicate when patients with pharyngeal dysphagia will benefit from a myotomy.
  
  
  BACKGROUND
  The pathophysiology of pharyngoesophageal swallowing disorders is complex. The disorder is of interest to several medical specialists (gastroenterologists, otorhinolaryngologists, general and thoracic surgeons), which contributes to confusion about the entity. The management is compounded because it is most frequently seen in the elderly, is often associated with generalized neuromuscular disease, and occurs with a high prevalence of concomitant disease. The selection of patients for myotomy is difficult and of major importance to the quality of life of the affected patients.
  
  
  METHODS
  One hundred seven patients without a Zenker diverticulum but with pharyngeal dysphagia underwent a detailed manometric assessment of the upper esophageal sphincter (UES). Cricopharyngeal opening was identified by the presence of a subatmospheric pressure drop before bolus arrival. Impaired pharyngoesophageal segment compliance resulting in a resistance to pharyngoesophageal flow was determined by measuring the intrabolus pressure generated by a 5-ml liquid bolus.
  
  
  RESULTS
  Thirty-one of 107 patients underwent a myotomy (29%). Both impaired sphincter opening and increased intrabolus pressure predicted a good outcome.
  
  
  CONCLUSIONS
  Myotomy is beneficial in patients with pharyngeal swallowing disorders and manometric evidence of defective sphincter opening and increased intrabolus pressure.
authors.affiliation: Department of Surgery, University of Southern California School of Medicine, Los Angeles 90033-4612, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Mason
authors.forename: C G
authors.initials: CG
authors.lastname: Bremner
authors.forename: T R
authors.initials: TR
authors.lastname: DeMeester
authors.forename: P F
authors.initials: PF
authors.lastname: Crookes
authors.forename: J H
authors.initials: JH
authors.lastname: Peters
authors.forename: J A
authors.initials: JA
authors.lastname: Hagen
authors.forename: S R
authors.initials: SR
authors.lastname: DeMeester
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003680:Deglutition Disorders / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D009132:Muscles / Q000601:surgery; D010608:Pharyngeal Diseases / Q000503:physiopathology / Q000601:surgery*