Polyploidy in myelodysplastic syndrome: a case report.
Structural chromosomal abnormalities are common in myelodysplastic syndromes (MDSs), and complex abnormalities are known to confer a poor prognosis. Polyploidy is rare. We report a patient with MDS in whom 8/15 cells were 77,XYY; 2/15 were 83,XYY, and 5/15 were diploid (46,XY). He experienced rapid evolution of disease, transforming to terminal acute leukemia.
Manley
R
R
Department of Haematology, Canterbury Health Laboratories, Christchurch, New Zealand.
Cochrane
J
J
Patton
W N
WN
D000208:Acute Disease; D000368:Aged; D018450:Disease Progression; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000209:etiology; D008297:Male; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D011123:Polyploidy