Ultrastructural findings of the endothelial cells in pancreatic lesions after chronic administration of methamphetamine in rats.
The effects of chronic administration of methamphetamine on the pancreas were studied using electron micrography in an experimental model. Methamphetamine (1 mg/kg/day) was subcutaneously injected in five-week-old male Wistar Kyoto rats (WKY) for 8 weeks. Five age and sex-matched WKY served as controls. In light microscopy, scattered necrosis, intercellular vacuolization and severe hemorrhage were the prominent lesions in the methamphetamine-treated rats. The associated ultrastructural alterations consisted of degenerated, swollen, mitochondria with disrupted cristae and cell debris in the superficial space of the endothelial cells, and extensive vacuolization in the degenerated endothelial cells of small vessels and in the smooth muscle cells of their wall. However, in this study, hypercontration or lamellar membrane-like changes were not identified. It is suggested that pancreatic necrotic hemorrhage is a consequence of methamphetamine damage to endothelial cells in various organs, including pancreas.
Ito
Y
Y
Department of Forensic Medicine, Saga Medical School, Japan.
Jono
H
H
Shojo
H
H
D000818:Animals; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D008694:Methamphetamine / Q000633:toxicity*; D008928:Mitochondria / Q000187:drug effects; D010179:Pancreas / Q000187:drug effects* / Q000648:ultrastructure; D051381:Rats; D011921:Rats, Inbred WKY
D008694:Methamphetamine