Flumethasone-induced insulin resistance in calves.
The impact of one single therapeutic dose of flumethasone (0.5 mg/100 kg b.w.) on insulin sensitivity was studied in calves. Hyperinsulinemic, euglycemic clamp tests were performed before and after flumethasone treatment. At 24 h after treatment, insulin-dependent glucose utilization was reduced by 74% (P < 0.005). No significant changes occurred 72 h post-treatment.
Sternbauer
K
K
Faculty of Veterinary Medicine, Department of Ruminant Medicine and Veterinary Epidemiology, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Luthman
J
J
Jacobsson
S O
SO
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D002417:Cattle; D005443:Flumethasone / Q000494:pharmacology*; D005938:Glucocorticoids / Q000494:pharmacology*; D015309:Glucose Clamp Technique; D007328:Insulin / Q000097:blood / Q000494:pharmacology; D007333:Insulin Resistance; D008297:Male
D001786:Blood Glucose; D005938:Glucocorticoids; D007328:Insulin; D005443:Flumethasone