title: Relationship between alcoholism and CYP2E1 C/D polymorphism.
abstract: The genotypes of the CYP2E1 loci of 35 alcoholic and 130 nonalcoholic (healthy controls) Japanese were investigated to determine the relationship between CYP2E1 (C/D) polymorphism and susceptibility to alcohol dependence. There was a significant (d.f. = 1, chi2 = 11.0, p < 0.001) difference in the CYP2E1 C gene frequency between alcohol dependents (0.41) and controls (0.28), suggesting that the C gene of CYP2E1 may be related to the risk of developing alcoholism in Japanese, whereas the frequency of the D gene was higher among controls than alcoholics. Healthy Japanese controls showed a significantly (d.f. = 1, chi2 = 30.1, p < 0.001) higher frequency of the C allele than Swedish healthy controls (0. 10) did.
authors.affiliation: Department of Neuropsychiatry, Kagawa Medical School, Miki-cho, Kita-gun, Kagawa, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Iwahashi
authors.forename: S
authors.initials: S
authors.lastname: Ameno
authors.forename: K
authors.initials: K
authors.lastname: Ameno
authors.forename: N
authors.initials: N
authors.lastname: Okada
authors.forename: H
authors.initials: H
authors.lastname: Kinoshita
authors.forename: Y
authors.initials: Y
authors.lastname: Sakae
authors.forename: K
authors.initials: K
authors.lastname: Nakamura
authors.forename: M
authors.initials: M
authors.lastname: Watanabe
authors.forename: I
authors.initials: I
authors.lastname: Ijiri
authors.forename: S
authors.initials: S
authors.lastname: Harada
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000201:enzymology* / Q000235:genetics*; D000483:Alleles; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007564:Japan; D008297:Male; D011110:Polymorphism, Genetic
chemical_list: D019392:Cytochrome P-450 CYP2E1