title: [Polymorphism of HLA-DQA1,-DQB1 genes in Uygur and Kazak ethnic groups and comprehensive analysis of 25 related populations].
abstract: HLA-DQA1 and -DQB1 genes were investigated in two Chinese minor natinalities, Uygur and Kazak using PCR-RFLP genotyping method. Of the 8 DQA1 alleles, DQA1 *0301 was the most common in Uygurs and Kazaks. DQA1 *0401 and *0601 were the rarest alleles in Uygurs and *0601 in Kazaks. Of the 16 DQB1 alleles tested, DQB1 *0201 and *0301 were the most frequent alleles in Uygurs and Kazaks. DQB1 *0502, *05032 and *0504 in Uygurs, *05032, *0504 and *0605 in Kazaks were absent. Neither DQA1 nor DQB1 difference was found between the two populations. From the phylogenetic tree based on the gene frequencies of HLA-DQA1 and -DQB1 in Uygur, Kazak and other 25 related ethnic groups, we suggest that Uygurs and Kazaks have a closer relationship, and they are closer to Mongoloid, not Caucasoid.
authors.affiliation: Institute of Genetics, Fudan University, Shanghai.
authors.forename: X N
authors.initials: XN
authors.lastname: Zhang
authors.forename: Y G
authors.initials: YG
authors.lastname: Liu
authors.lastname: Pazilaiti
authors.forename: D
authors.initials: D
authors.lastname: Li
authors.forename: X
authors.initials: X
authors.lastname: Li
authors.forename: R X
authors.initials: RX
authors.lastname: Huang
authors.forename: G Q
authors.initials: GQ
authors.lastname: Li
authors.forename: D L
authors.initials: DL
authors.lastname: Zhu
authors.forename: Z C
authors.initials: ZC
authors.lastname: Geng
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D002681:China / Q000208:ethnology; D005260:Female; D006683:HLA-DQ Antigens / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D044465:White People / Q000235:genetics
chemical_list: D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; C069050:HLA-DQA1 antigen; C069051:HLA-DQB1 antigen