title: Expression and localization in the fish retina of a homologue of the Alzheimer's related PS1 gene.
abstract: Early-onset familial Alzheimer's disease (early-onset FAD) has been linked with mutations in the presenilin gene, PS1. Mutations in PS1 may affect the processing/ trafficking of beta-amyloid precursor-protein (betaAPP) and favour the production of toxic amyloid-beta fragments that are associated with neural degeneration. This study reports the expression of a PS1-like cDNA in the carp (Cyprinus carpio) retina (the encoded protein shows 76% identity to the human PS1 protein). Carp PS1 mRNA was localized by in situ hybridization to the photoreceptor cell, inner nuclear and ganglion cell layers. Expression of the PS1 gene in the rat retina was also confirmed. The retinal expression of PS1 raises the possibility that PS1 mutations also lead to neural degeneration in the retina.
authors.affiliation: International Marine Centre, Molecular Biology Group, Oristano, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Archer
authors.forename: J
authors.initials: J
authors.lastname: Hirano
authors.forename: J K
authors.initials: JK
authors.lastname: Diss
authors.forename: S P
authors.initials: SP
authors.lastname: Fraser
authors.forename: M B
authors.initials: MB
authors.lastname: Djamgoz
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017173:Caenorhabditis elegans; D002347:Carps; D003001:Cloning, Molecular; D017124:Conserved Sequence; D004331:Drosophila melanogaster; D005260:Female; D006801:Humans; D017403:In Situ Hybridization; D008565:Membrane Proteins / Q000032:analysis* / Q000096:biosynthesis* / Q000235:genetics; D051379:Mice; D008969:Molecular Sequence Data; D053764:Presenilin-1; D051381:Rats; D012160:Retina / Q000737:chemistry / Q000166:cytology; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D014981:Xenopus
chemical_list: D008565:Membrane Proteins; C508853:PSEN1 protein, human; D053764:Presenilin-1