title: [Ulcer + ulcer].
abstract: We report on an elderly woman suffering from an acutely bleeding duodenal ulcer. Apart from old age and a history of gastrointestinal ulcer there were no risk factors detectable. However, clinical examination revealed that the patient had put a diclofenac hydroxyethylpyrrolidine plaster, which had been prescribed for lower back pain, inadvertently on a large ulcus cruris. The diclofenac serum concentration was 80 mu/l corresponding to a therapeutic serum level. This case demonstrates that false application of new pharmaceutical formulation may lead to inadvertent side-effects.
authors.affiliation: Departement Innere Medizin, Universitätsspital Zürich.
authors.forename: D N
authors.initials: DN
authors.lastname: Stocker
authors.forename: A D
authors.initials: AD
authors.lastname: Christ
authors.forename: R
authors.initials: R
authors.lastname: Speich
mesh_terms: D000287:Administration, Topical; D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D001416:Back Pain / Q000097:blood / Q000188:drug therapy; D001458:Bandages; D004008:Diclofenac / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D004381:Duodenal Ulcer / Q000097:blood / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D010438:Peptic Ulcer Hemorrhage / Q000097:blood / Q000139:chemically induced* / Q000473:pathology; D014647:Varicose Ulcer / Q000097:blood / Q000188:drug therapy*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; C064142:diclofenac hydroxyethylpyrrolidine; D004008:Diclofenac