[Activating blood circulation and removing stasis in treating polycythemia vera: clinical observation and therapeutical mechanism].
OBJECTIVE
To assess the efficacy of "method of activating blood circulation and removing stasis (ABCRS)" in treating polycythemia vera.


METHODS
28 cases of polycythemia vera were treated with ABCRS and observed with bone marrow colonies.


RESULTS
15 casses were responsibe, of them 4 cases reached clinical remission, 11 cases were improved. Both bone marrow colonies of colony forming unit-erythroid dependent of erythropoietin (EPO + CFU-E) and colonies of CFU-E independent of EPO. (EPO-CFU-E) from these cases decreased significantly, especially the latter. ABCRS mainly suppressed the proliferation and differentiation of EPO-CFU-E. In addition, bone marrow colonies of colony formng unit-fibroblastoids (CFU-F) from these cases also changed obviously.


CONCLUSIONS
ABCRS is effective in treating polycythemia vera.
Tang
X P
XP
Institute of Hematology, Chinese Academy of Medical Sciences, Tianjin.
Tian
Z
Z
Zhang
D
D
D000328:Adult; D000368:Aged; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004906:Erythrocyte Count; D015672:Erythroid Precursor Cells / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011087:Polycythemia Vera / Q000188:drug therapy*
D004365:Drugs, Chinese Herbal