[Inhibition of voltage-dependent K+ currents in rat C6 glioma cells by haloperidol and R(-)-NPA].
In this study, the inhibitory effects of R(-)-NPA (R(-)-Propylnorapomorphine) and haloperidol on voltage-dependent K+ currents in rat C6 glioma cells (C6 cells) were observed by means of the whole-cell patch-clamp recording technique. The mechanisms of the effects were also analyzed. The main results were as follows: (1) Both R(-)-NPA and haloperidol could inhibit K+ currents dose-dependently and reversibly in C6 cells. (2) R(-)-NPA and haloperidol inhibited mainly the slow component of the K+ currents. (3) These inhibitory responses were not mediated by dopamine receptors or dependent on G-proteins and intracellular calcium. It was suggested that they refer to some direct action on K+ channels.
Xie
Z
Z
Shanghai Brain Research Institute, Chinese Academy of Sciences.
He
S F
SF
D000818:Animals; D001058:Apomorphine / Q000031:analogs & derivatives* / Q000494:pharmacology; D001693:Biological Transport, Active; D001932:Brain Neoplasms / Q000473:pathology*; D018491:Dopamine Agonists / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology; D005910:Glioma / Q000473:pathology*; D006220:Haloperidol / Q000494:pharmacology*; D015221:Potassium Channels / Q000187:drug effects*; D051381:Rats; D014407:Tumor Cells, Cultured
D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D015221:Potassium Channels; C009074:N-n-propylnorapomorphine; D006220:Haloperidol; D001058:Apomorphine