title: Short report: total serum levels of the nitric oxide derivatives nitrite/nitrate during microfilarial clearance in human filarial disease.
abstract: Nitric oxide (NO) has recently been shown to be cytotoxic to both microfilariae and adult Brugia malayi in vitro and in a murine model, as well against Onchocerca lienalis microfilariae in vitro. We studied the kinetics of nitrite/nitrate, both stable end products of NO, by high-pressure liquid chromatography during microfilaricidal chemotherapy in four filariasis (three Loa loa, and one Onchocerca volvulus) patients. High serum levels of nitrite/nitrate were released during microfilarial clearance and sustained elevated levels were observed six months after chemotherapy, suggesting a role of NO in the elimination of microfilariae in human filariasis.
authors.affiliation: Department of Infectious Diseases, Internal Medicine I, University of Vienna, Austria.
authors.forename: S
authors.initials: S
authors.lastname: Winkler
authors.forename: I
authors.initials: I
authors.lastname: El Menyawi
authors.forename: K F
authors.initials: KF
authors.lastname: Linnau
authors.forename: W
authors.initials: W
authors.lastname: Graninger
mesh_terms: D000328:Adult; D000818:Animals; D005260:Female; D005368:Filariasis / Q000097:blood / Q000209:etiology*; D006801:Humans; D008297:Male; D008842:Microfilariae; D009566:Nitrates / Q000097:blood*; D009569:Nitric Oxide / Q000502:physiology*; D009573:Nitrites / Q000097:blood*
chemical_list: D009566:Nitrates; D009573:Nitrites; D009569:Nitric Oxide