[Infrared A radiation-controlled permeation of tetracaine in vitro and in vivo].
Waterfiltered infrared light (IR-A) was investigated as permeation enhancer for transdermal drug delivery systems on biological membranes. Due to the IR-A-radiation pulse on human keratinocytes (HaCaT) a clear increase in the permeability of tetracaine was recognizable. In vivo studies showed IR-A-supported enhanced local analgesia of tetracaine hydrogel in the pin prick test. The study leads to the conclusion, that IR-A-radiation can specifically be used to optimize transdermal drug permeation.
Haupenthal
H
H
Institut für Pharmazie, Johannes Gutenberg-Universität Mainz, Germany.
Moll
F
F
D000279:Administration, Cutaneous; D000779:Anesthetics, Local / Q000493:pharmacokinetics*; D002463:Cell Membrane Permeability / Q000528:radiation effects; D002478:Cells, Cultured; D006801:Humans; D007259:Infrared Rays; D015603:Keratinocytes / Q000528:radiation effects; D008422:Materials Testing; D013748:Tetracaine / Q000493:pharmacokinetics*
D000779:Anesthetics, Local; D013748:Tetracaine