In vitro study of the percutaneous absorption of four aromatic amines using hairless rat skin.
Using hairless rat skin maintained in a Franz diffusion cell, the percutaneous penetration of four aromatic amines: para-chloroaniline (PCPA), meta-trifluoromethylaniline (mTFMA), dichloro-3,4-aniline (3,4-DCA) and dichloro-3,5-aniline (3,5-DCA) were studied. The purpose of the studies was to determine the permeation parameters (rate of permeation, permeability rat constant) in order to compare the rate of absorption of the four amines. The results show that the four amines penetrate significantly across the skin, but with different rates. 10 h after in vitro application (2 mg/cm2), the extent of permeation was PCPA >> mTFMA > 3,4-DCA > 3,5-DCA.
Levillain
F
F
Laboratoire de Cinétique des Xénobiotiques, Faculté des Sciences, Pharmaceutiques, Université de Toulouse, France.
Charasson
V
V
el Marbouh
L
L
Poëy
J
J
Houin
G
G
D000814:Aniline Compounds / Q000493:pharmacokinetics*; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D006207:Half-Life; D066298:In Vitro Techniques; D051381:Rats; D011919:Rats, Inbred Strains; D012869:Skin Absorption; D013056:Spectrophotometry, Ultraviolet
D000814:Aniline Compounds