title: Effects of successful adenomectomy on body composition in acromegaly.
abstract: The purpose of the present study was to investigate postsurgical change in body composition in patients who have undergone surgery for acromegaly. Eight patients with acromegaly had determination of serum GH, insulin-like growth factor-I (IGF-I), height, body weight, and bioelectric impedance before surgery and at 2 weeks, 1 month, 3 months, and 6 months after surgery. Body composition was analyzed by bioelectric impedance analysis (BIA). We analyzed body fat (BF), body lean mass (BLM), body cell mass (BCM), total body water (TBW), intracellular water (ICW) and extracellular water (ECW). The serum GH concentration and IGF-I had decreased significantly 2 weeks after surgery. Body weight had decreased significantly 1 month after surgery and recovered 3 months after surgery. BIA showed that TBW and BCM had decreased significantly 2 weeks after surgery. BF gradually increased up to 1 month after surgery and was increased significantly at 3 months after surgery. The percent ratio of TBW/body weight decreased and the percent ratio of BF/body weight increased during the 6 months after surgery. The percent ratio of ECW/TBW did not change during the 6 months following surgery. In conclusion, the rapid body weight loss which occurred within 2 weeks after surgery was caused by decreases in TBW and BCM. The recovery of body weight, which was seen later than 1 month after surgery, was caused by an increase in BF. The postoperative change in body composition in acromegaly ceased 3 months after surgery.
authors.affiliation: Department of Neurosurgery, Hiroshima University, School of Medicine, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Tominaga
authors.forename: K
authors.initials: K
authors.lastname: Arita
authors.forename: K
authors.initials: K
authors.lastname: Kurisu
authors.forename: T
authors.initials: T
authors.lastname: Uozumi
authors.forename: K
authors.initials: K
authors.lastname: Migita
authors.forename: K
authors.initials: K
authors.lastname: Eguchi
authors.forename: K
authors.initials: K
authors.lastname: IIda
authors.forename: H
authors.initials: H
authors.lastname: Kawamoto
authors.forename: T
authors.initials: T
authors.lastname: Mizoue
mesh_terms: D000172:Acromegaly / Q000601:surgery*; D000236:Adenoma / Q000601:surgery*; D000368:Aged; D001823:Body Composition; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000601:surgery*; D011184:Postoperative Period; D016896:Treatment Outcome