Circadian elevation of IL-6 levels in Muckle-Wells syndrome: a disorder of the neuro-immune axis?
Muckle-Wells syndrome (MWS) is a rare autosomal dominant hereditary disorder characterized by chronic recurrent urticaria, arthralgia, sensorineural deafness, and in some cases nephropathy due to amyloidosis (AA type). We report a 21-year-old woman and her father, both suffering from this syndrome, in whom elevated serum levels of IL-6 could be documented during the flares of urticaria, and discuss the relevance of this finding for MWS.
Gerbig
A W
AW
Department of Dermatology, University of Bern, Switzerland.
Dahinden
C A
CA
Mullis
P
P
Hunziker
T
T
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D018771:Arthralgia / Q000276:immunology*; D002940:Circadian Rhythm; D003638:Deafness / Q000276:immunology; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D015166:Monitoring, Immunologic; D013577:Syndrome; D014581:Urticaria / Q000276:immunology*
D015850:Interleukin-6