title: Four acetylcholinesterase genes in the nematode Caenorhabditis elegans.
abstract: Whereas a single gene encodes acetylcholinesterase (AChE) in vertebrates and most insect species, four distinct genes have been cloned and characterized in the nematode Caenorhabditis elegans. We found that ace-1 (mapped to chromosome X) is prominently expressed in muscle cells whereas ace-2 (located on chromosome I) is mainly expressed in neurons. Ace-x and ace-y genes are located in close proximity on chromosome II where they are separated by only a few hundred base pairs. The role of these two genes is still unknown.
authors.affiliation: Groupe Cholinestérases, DCC-Inra, Montpellier, France.
authors.forename: M
authors.initials: M
authors.lastname: Arpagaus
authors.forename: D
authors.initials: D
authors.lastname: Combes
authors.forename: E
authors.initials: E
authors.lastname: Culetto
authors.forename: M
authors.initials: M
authors.lastname: Grauso
authors.forename: Y
authors.initials: Y
authors.lastname: Fedon
authors.forename: R
authors.initials: R
authors.lastname: Romani
authors.forename: J P
authors.initials: JP
authors.lastname: Toutant
mesh_terms: D000110:Acetylcholinesterase / Q000235:genetics* / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D017173:Caenorhabditis elegans / Q000201:enzymology / Q000235:genetics*; D008969:Molecular Sequence Data; D014018:Tissue Distribution
chemical_list: D000110:Acetylcholinesterase