Expression of the AMPA-type glutamate receptor subunits in the chick optic tectum changes biphasically after retinal deafferentation.
Effects of retinal lesions on the expression of AMPA-type glutamate receptor (GluR) subunits in the chick optic tectum were evaluated with immunohistochemistry and immunoblotting. Expression of GluR1 and GluR2/3 subunits decreased in the deafferented tectum after 2 days and increased after 7 days postlesion. These results suggest biphasic effects of retinal lesions upon the expression of GluR subunits, possibly due to removal of the glutamatergic input from the retina.
Pires
R S
RS
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 1524, 05508-900, São Paulo, S.P., Brazil.
Ferro
E S
ES
Britto
L R
LR
D000818:Animals; D002470:Cell Survival / Q000502:physiology; D002645:Chickens / Q000502:physiology*; D003714:Denervation; D006651:Histocytochemistry; D007091:Image Processing, Computer-Assisted; D009475:Neurons, Afferent / Q000502:physiology*; D018091:Receptors, AMPA / Q000096:biosynthesis*; D012160:Retina / Q000502:physiology*; D013477:Superior Colliculi / Q000378:metabolism*
D018091:Receptors, AMPA