Anti-inflammatory activity of acetophenones from Ophryosporus axilliflorus.
Seven acetophenone derivatives were isolated from the aerial parts of Ophryosporus axilliflorus (Griseb.) Hieron. These compounds were subjected to the carrageenan-induced mouse paw edema test where tremetone (7) showed extremely anti-inflammatory activity. Furthermore, the non-benzofuran acetophenones 5 and 6, showed a significant response.
Favier
L
L
Tonn
C
C
Guerreiro
E
E
Rotelli
A
A
Pelzer
L
L
D000098:Acetophenones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*
D000098:Acetophenones; D000894:Anti-Inflammatory Agents, Non-Steroidal