title: Management of acute diarrhoea with low osmolarity oral rehydration solutions and Lactobacillus strain GG.
abstract: Two hypotonic oral rehydration solutions with osmolarities of 224 mosmol/l (Na+ 60 mmol/l, glucose 84 mmol/l) and 204 mosmol/l (Na+ 60 mmol/l, glucose 64 mmol/l), respectively, and oral treatment with Lactobacillus GG were evaluated in a double blind trial in children aged 6-36 months hospitalised for acute diarrhoea. Early administration of Lactobacillus GG at the start of oral rehydration resulted in the shortest duration of diarrhoea, best weight gain, and fastest correction of acidosis. A reduced osmolarity oral rehydration solution (224 mosmol/l) combined with early administration of Lactobacillus GG is an effective treatment for acute diarrhoea in young children; further reduction of osmolarity may not be beneficial.
authors.affiliation: Department of Paediatrics, Jorvi Hospital, Espoo, Finland.
authors.forename: T
authors.initials: T
authors.lastname: Rautanen
authors.forename: E
authors.initials: E
authors.lastname: Isolauri
authors.forename: E
authors.initials: E
authors.lastname: Salo
authors.forename: T
authors.initials: T
authors.lastname: Vesikari
mesh_terms: D000208:Acute Disease; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003968:Diarrhea, Infantile / Q000628:therapy*; D004311:Double-Blind Method; D006801:Humans; D007223:Infant; D007778:Lactobacillus; D009994:Osmolar Concentration; D015532:Rehydration Solutions / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome; D015430:Weight Gain
chemical_list: D015532:Rehydration Solutions