STCP-1 (MDC) CC chemokine acts specifically on chronically activated Th2 lymphocytes and is produced by monocytes on stimulation with Th2 cytokines IL-4 and IL-13.
STCP-1 stimulated T cell chemoattractant protein-1 (STCP-1) (macrophage-derived chemokine; MDC), a recently described CC chemokine for chronically activated T lymphocytes, was found to act specifically on a subset of memory CD4 lymphocytes that displayed a Th2 cytokine profile. Also, STCP-1, thymus and activation regulated chemokine (TARC), eotaxin, and eotaxin-2 acted specifically on in vitro derived Th2 lymphocytes, while IP-10 (IFN-gamma-inducible 10-kDa protein) showed some preference for Th1 lymphocytes. The corresponding receptors for eotaxin, TARC, and IP-10 are also differentially expressed on Th1 and Th2 lymphocytes. In desensitization Ca flux experiments, TARC and STCP-1 bound to a common receptor and therefore at least one chemokine receptor for STCP-1 is CCR4. STCP-1 expression is restricted to immune cells. Dendritic cells, B cells, and macrophages produce STCP-1 constitutively, while NK cells, monocytes, and CD4 lymphocytes produce STCP-1 upon appropriate stimulation. Production of STCP-1 is positively modulated by Th2 cytokines IL-4 and IL-13 but inhibited by IL-10.
Andrew
D P
DP
Amgen Inc., Boulder, CO 80301, USA. dandrew@hotmail.com
Chang
M S
MS
McNinch
J
J
Wathen
S T
ST
Rihanek
M
M
Tseng
J
J
Spellberg
J P
JP
Elias
C G
CG
D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism; D020013:Calcium Signaling; D054413:Chemokine CCL11; D054414:Chemokine CCL17; D054422:Chemokine CCL22; D054423:Chemokine CCL24; D018946:Chemokine CCL5 / Q000494:pharmacology; D054357:Chemokine CXCL10; D018925:Chemokines / Q000494:pharmacology*; D019742:Chemokines, CC / Q000096:biosynthesis / Q000494:pharmacology / Q000502:physiology*; D019743:Chemokines, CXC / Q000494:pharmacology; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D016207:Cytokines / Q000494:pharmacology; D003713:Dendritic Cells / Q000378:metabolism; D005246:Feedback; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology; D006801:Humans; D007156:Immunologic Memory; D016753:Interleukin-10 / Q000494:pharmacology; D018793:Interleukin-13 / Q000494:pharmacology / Q000502:physiology*; D015847:Interleukin-4 / Q000494:pharmacology / Q000502:physiology*; D007694:Killer Cells, Natural / Q000378:metabolism; D008213:Lymphocyte Activation; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D009000:Monocytes / Q000187:drug effects* / Q000378:metabolism; D054397:Receptors, CCR3; D054398:Receptors, CCR4; D054367:Receptors, CXCR3; D019707:Receptors, Chemokine / Q000032:analysis / Q000187:drug effects* / Q000502:physiology
C515456:CCL11 protein, human; C106230:CCL17 protein, human; C515482:CCL22 protein, human; C515484:CCL24 protein, human; C515350:CCR3 protein, human; C515354:CCR4 protein, human; C515187:CXCR3 protein, human; C515457:Ccl11 protein, mouse; C499538:Ccl17 protein, mouse; C515483:Ccl22 protein, mouse; C515485:Ccl24 protein, mouse; C515351:Ccr3 protein, mouse; C515355:Ccr4 protein, mouse; D054413:Chemokine CCL11; D054414:Chemokine CCL17; D054422:Chemokine CCL22; D054423:Chemokine CCL24; D018946:Chemokine CCL5; D054357:Chemokine CXCL10; D018925:Chemokines; D019742:Chemokines, CC; D019743:Chemokines, CXC; C515188:Cxcr3 protein, mouse; D016207:Cytokines; D018793:Interleukin-13; D054397:Receptors, CCR3; D054398:Receptors, CCR4; D054367:Receptors, CXCR3; D019707:Receptors, Chemokine; D016753:Interleukin-10; D015847:Interleukin-4; D016178:Granulocyte-Macrophage Colony-Stimulating Factor