Anti-inflammatory effects of mao-bushi-saishin-to in mice and rats.
Effects of Mao-Bushi-Saishin-to (MBS) on anti-inflammatory activities were examined in mice and rats. MBS significantly inhibited the increase in vascular permeability induced by acetic acid, the ear edema induced by arachidonic acid and phorbol ester, and the cutaneous extravasation induced by bradykinin and histamine. MBS, however, was not effective against the serotonin-induced cutaneous permeability increase in mice. MBS significantly inhibited carrageenin-induced hind foot edema and cotton pellet-induced granulation tissue growth in rats. These results show that MBS may exert anti-inflammatory effects through the underlying mechanism(s) of preventing mediator release from mast cells and macrophages.
Ikeda
Y
Y
Central Research Laboratories, Tsumura & Co., Ibaraki, Japan.
Iijima
O T
OT
Iizuka
A
A
Ishige
A
A
Amagaya
S
S
Komatsu
Y
Y
Okada
M
M
Abe
C
C
Fujihira
E
E
D019342:Acetic Acid; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D016718:Arachidonic Acid; D002199:Capillary Permeability / Q000187:drug effects; D002351:Carrageenan; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010703:Phorbol Esters; D010936:Plant Extracts; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; D010703:Phorbol Esters; D010936:Plant Extracts; D016718:Arachidonic Acid; D002351:Carrageenan; D019342:Acetic Acid