Effects of a low concentration of isoflurane on contrast sensitivity in volunteers.
The effects of 0.15% quasi steady-state end-tidal isoflurane on the contrast sensitivity of five healthy volunteers were investigated by measuring their performance in computer generated letter discrimination tasks. A series of letters were displayed on a computer screen so that the luminance of the letter differed from that of the background. Two protocols were used: in the static protocol, the letter remained displayed on the screen until the subject responded, whereas in the dynamic protocol, the letter was displayed for 1/72 s only. Isoflurane significantly decreased contrast sensitivity in both protocols in all subjects.
Taylor
S R
SR
University Department of Anaesthesia, Addenbrooke's Hospital, Cambridge.
Khan
O A
OA
Swart
M L
ML
Lockwood
G G
GG
Jones
J G
JG
D000762:Anesthesia Recovery Period; D000769:Anesthesia, Inhalation; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D003196:Computer Graphics; D015350:Contrast Sensitivity / Q000187:drug effects*; D004192:Discrimination, Psychological / Q000187:drug effects; D006801:Humans; D007530:Isoflurane / Q000494:pharmacology*; D012684:Sensory Thresholds / Q000187:drug effects
D018685:Anesthetics, Inhalation; D007530:Isoflurane