title: Langerhans cell histocytosis--a clinicopathological spectrum.
abstract: Langerhans cell Histiocytosis--a lesion characterised by proliferation of a variant of epidermal dendritic cell is one of the several syndromes in which histiocytes play a principal role in pathogenesis outside the context of inflammatory and metabolic storage disease. Seven cases were diagnosed as Langerhans cell Histiocytosis over a period of six years. The mode of diagnosis was Fine needle aspiration in 2 cases, open biopsy in four, and both biopsy and FNAC in one. The age range was from 2 months to 58 years and four of the seven patients were males. The lesion was unifocal in 3 cases (two in bone and one involving skin and soft tissue), multifocal in 3 and systemic in one. Electron microscopy was done in one case to demonstrate Birbeck granules. Immunohistochemical demonstration of S 100 protein was done in one case. The clinicopathologic spectrum of Langerhans cell Histiocytosis is brought out in this presentation of seven cases.
authors.affiliation: Anand Institute of Laboratory Medicine, Bangalore.
authors.forename: N
authors.initials: N
authors.lastname: Jayaram
authors.forename: A V
authors.initials: AV
authors.lastname: Ramprasad
authors.forename: R P
authors.initials: RP
authors.lastname: Sujay
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D001707:Biopsy, Needle; D002675:Child, Preschool; D003713:Dendritic Cells / Q000473:pathology; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000473:pathology*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000473:pathology
chemical_list: D015415:Biomarkers