Clobazam exerts an anticonvulsant action in immature rats.
The anticonvulsant action of 1,5-benzodiazepine clobazam was studied in 12-, 18-, and 25-day-old rats. Cortical epileptic afterdischarges (ADs) elicited by rhythmic electrical stimulation of the sensorimotor cortical area were used as a model in animals with implanted electrodes. As far as the duration of ADs is concerned, clobazam in doses of 1 or 5 mg/kg i.p. blocked the progressive increase with repeated stimulations in all age groups and the higher dose significantly shortened ADs in 25-day-old rats. The intensity of movements accompanying stimulation was decreased only by the 5 mg/kg dose in 25-day-old animals, whereas clonic seizures were less intense after both doses in 12- and 25-day-old rat pups. Clobazam exerted an anticonvulsant action at all the developmental stages studied; the lower efficacy in 18-day-old rats (described also for clonazepam) remains to be analyzed.
Slamberová
R
R
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
Mares
P
P
Vorlícek
J
J
D000375:Aging; D000818:Animals; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D000927:Anticonvulsants; D001569:Benzodiazepines; D000078306:Clobazam; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D004827:Epilepsy / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D005625:Frontal Lobe; D008297:Male; D009044:Motor Cortex; D009778:Occipital Lobe; D051381:Rats; D017208:Rats, Wistar
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D001569:Benzodiazepines; D000078306:Clobazam