title: Molecular interactions of acetylcholinesterase with senile plaques.
abstract: Acetylcholinesterase (AChE) present in Alzheimer plaques is resistant to low pH, anti-ChE inhibitors and high substrate concentrations in comparison with the free enzyme. Kinetic and pharmacological studies of AChE-amyloid complexes indicate that steric hindrance by the amyloid over the gorge and the peripheral site of AChE is responsible for these effects.
authors.affiliation: Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors.forename: N C
authors.initials: NC
authors.lastname: Inestrosa
authors.forename: R
authors.initials: R
authors.lastname: Alarcón
mesh_terms: D000110:Acetylcholinesterase / Q000502:physiology*; D000544:Alzheimer Disease / Q000201:enzymology / Q000473:pathology; D000818:Animals; D006801:Humans; D058225:Plaque, Amyloid / Q000201:enzymology*
chemical_list: D000110:Acetylcholinesterase