title: A study of HLA-DPB1 phenotypes reveals DPB1*6301 in a rural population from Cameroon.
abstract: Several recently reported HLA-DPB1 alleles have only been identified in a single family or individuals and are of unknown distribution world-wide. Many new DPB1 alleles appear to arise as a result of gene conversion-like events, which may localize variant DPB1 alleles to the population in which they were first identified. Using two SSOP-based typing methods in parallel, we have identified HLA-DPB1*6301 in an individual from rural Cameroon which has previously only been reported in a family of Mexican-American origin. The presence of DPB1*6301 was confirmed by sequence-based typing of exon 2.
authors.affiliation: ARC Epidemiology Research Unit, Manchester University, UK.
authors.forename: K V
authors.initials: KV
authors.lastname: Poulton
authors.forename: L J
authors.initials: LJ
authors.lastname: Kennedy
authors.forename: J
authors.initials: J
authors.lastname: Ross
authors.forename: W
authors.initials: W
authors.lastname: Thomson
authors.forename: J C
authors.initials: JC
authors.lastname: Mbanya
authors.forename: W E
authors.initials: WE
authors.lastname: Ollier
mesh_terms: D000483:Alleles; D002163:Cameroon; D006682:HLA-DP Antigens / Q000235:genetics*; D059868:HLA-DP beta-Chains; D006801:Humans; D010641:Phenotype; D016133:Polymerase Chain Reaction / Q000379:methods; D012424:Rural Population
chemical_list: D006682:HLA-DP Antigens; D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen