title: Atrial flutter with 1:1 atrioventricular conduction caused by propafenone.
abstract: We describe a case of 1:1 atrial flutter in a patient with coronary disease taking propafenone. In atrial flutter, the atrial rate is usually about 300 beats/min with 2:1 AV conduction and a ventricular rate of 150 beats/min. Class IA antiarrhythmic drugs, especially quinidine and disopyramide, may cause 1:1 AV response because they reduce atrial rate and are vagolytic. However, propafenone is a Class IC agent and has no anticholinergic properties, and the occurrence of 1:1 AV conduction at a rate of about 250 beats/min is an important side effect that, although uncommon, should be recognized.
authors.affiliation: Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom.
authors.forename: M B
authors.initials: MB
authors.lastname: el-Harari
authors.forename: P C
authors.initials: PC
authors.lastname: Adams
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000188:drug therapy; D001282:Atrial Flutter / Q000139:chemically induced*; D001283:Atrioventricular Node / Q000187:drug effects*; D001026:Coronary Artery Bypass; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy; D011405:Propafenone / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000889:Anti-Arrhythmia Agents; D011405:Propafenone