In vitro activity of a new polyene, SPA-S-843, against yeasts.
The in vitro activity of a new water-soluble polyene, SPA-S-843, was evaluated against 116 strains of Candida, Cryptococcus, and Saccharomyces spp. and compared with that of amphotericin B. SPA-S-843 demonstrated better inhibitory activity against all of the yeasts examined and better fungicidal activity against Candida albicans, Candida glabrata, Candida krusei, and Candida tropicalis than did amphotericin B.
Rimaroli
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Research Laboratories, Società Prodotti Antibiotici SpA, 20143 Milan, Italy. dm@apm.it
Bruzzese
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D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D003454:Cryptococcus / Q000187:drug effects; D011090:Polyenes / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D015003:Yeasts / Q000187:drug effects*
D000935:Antifungal Agents; D011090:Polyenes; C115650:SPA S 843; D000666:Amphotericin B