[Tissue concentration and secretion of renin in human placental villi during early pregnancy].
In this study, tissue concentrations of renin and angiotensins in human placental villi during early pregnancy and contents of renin and angiotensin I (A I) secreted by cultured chorion were measured by radioimmunal assay (RIA). The results are as follows. During early pregnancy, the human chorion contains renin and A II. The activity of renin is much higher at 6th week of gestation, but as gestation proceeds, it decreases gradually, while A II shows somewhat increased change. The activity of renin secreted by cultured chorion can also be measured. A I in human placental villi can not be detected by RIA in chorion leaves or their culturing fluid. These results indicate that renin-angiotensin system may exist independently in human placental villi during early pregnancy.
Chen
Z K
ZK
State Key Laboratory of Reproductive Biology, Institute of Zoology, Academia Sinica, Beijing.
Jiao
L H
LH
Yan
J S
JS
Wang
H
H
D000803:Angiotensin I / Q000378:metabolism*; D000804:Angiotensin II / Q000378:metabolism*; D002478:Cells, Cultured; D002824:Chorionic Villi / Q000378:metabolism*; D005260:Female; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy / Q000502:physiology*; D011261:Pregnancy Trimester, First; D012083:Renin / Q000378:metabolism*
D000804:Angiotensin II; D000803:Angiotensin I; D012083:Renin