title: Distribution of macrovascular disease in scleroderma.
abstract: OBJECTIVE
  Macrovascular disease in scleroderma has recently been described in two comparative studies. The aim of this study was to map its anatomical distribution.
  
  
  METHODS
  In a retrospective cohort study of 20 scleroderma patients, the results of Doppler studies of arteries in the limbs, neck, and abdomen were compared with those from 20 cohort negative patients. The latter were matched for age, sex, and the presence/absence of hypertension, hyperlipidaemia, smoking, and diabetes status. Arteries were compared quantitatively using a body surface area adjusted measurement of intraluminal diameter, and qualitatively using descriptive characteristics of the arterial walls. The latter were binomially categorised under three non-exclusive headings--thickening, stenosis, and calcification.
  
  
  RESULTS
  The ulnar arteries in scleroderma patients were significantly narrower than those of the negative cohort. The arterial walls were also characterised by smooth thickening along their entire length. The characteristics of the other arteries, including those of the lower limbs, were not significantly different from those of the negative cohort.
  
  
  CONCLUSIONS
  The ulnar artery seems to be specifically targeted in patients with scleroderma. Assessment of the ulnar artery should be considered in these patients by means of a modified Allen's test or Doppler sonography especially in the presence of digital gangrene.
authors.affiliation: Department of Rheumatology, Prince Henry Hospital, Sydney, Australia.
authors.forename: L
authors.initials: L
authors.lastname: Stafford
authors.forename: H
authors.initials: H
authors.lastname: Englert
authors.forename: J
authors.initials: J
authors.lastname: Gover
authors.forename: J
authors.initials: J
authors.lastname: Bertouch
mesh_terms: D000368:Aged; D000671:Amputation, Surgical; D017153:Antibodies, Anticardiolipin / Q000097:blood; D001157:Arterial Occlusive Diseases / Q000209:etiology / Q000473:pathology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007866:Leg / Q000601:surgery; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000209:etiology*; D012189:Retrospective Studies; D012307:Risk Factors; D012595:Scleroderma, Systemic / Q000150:complications* / Q000276:immunology; D017535:Ulnar Artery / Q000473:pathology
chemical_list: D017153:Antibodies, Anticardiolipin