Acute hemolytic crisis with fulminant hepatic failure as the first manifestation of Wilson's disease: a case report.
We report a 27-year-old woman who developed Coombs' negative hemolytic anemia and fulminant hepatic failure as the initial manifestation of Wilson's disease. Unmeasurably low level of serum alkaline phosphatase provided a clue to the diagnosis of Wilson's disease. The diagnosis was established with the presence of Kayser-Fleischer ring, decreased serum ceruloplasmin level, and elevated urine and serum copper levels. In spite of repeated plasmapheresis, she died of multiorgan failure on the fifth hospital day.
Lee
J J
JJ
Department of Internal Medicine, Chonnam National University Medical School, Kwangju, Korea.
Kim
H J
HJ
Chung
I J
IJ
Kook
H
H
Byun
J R
JR
Kwon
S Y
SY
Park
M R
MR
Choi
K S
KS
Hwang
T J
TJ
Ryang
D W
DW
D000208:Acute Disease; D000328:Adult; D000743:Anemia, Hemolytic / Q000150:complications*; D003298:Coombs Test; D005260:Female; D006501:Hepatic Encephalopathy / Q000150:complications* / Q000503:physiopathology; D006527:Hepatolenticular Degeneration / Q000150:complications* / Q000503:physiopathology; D006801:Humans