title: [Receptors of monoamine in sympathetic preganglionic neurons of neonatal rat spinal cord in vitro].
abstract: By means of intracellular recordings from spinal cord slices of neonatal rats in vitro, the effects of 5-hydroxytryptamine (5-HT), nor-adrenaline (NA) and adrenaline (AD) on membrane potential in sympathetic preganglionic neurons (SPN) were observed, in order to clarify whether these neuron contain a single type of the monoamine receptor or in combination with more than one type of receptors. The results showed that: (1) 5-HT, NA and AD induced membrane depolarization respectively in 57.1% (16/28), 60% (15/25) and 52.4% (11/21) of SPN. (2) According to the reactions of SPN to the three monoamines, several subtypes of SPN could be divided: those sensitive to all the three monoamines (3/19), those sensitive to two of them (9/19), those only sensitive to one type of monoamines (4/19) and those insensitive at all (3/19). The significance of coexistence of more than one type of the three monoamines in a single neuron remains to be elucidated.
authors.affiliation: Department of Physiology, Anhui Medical University, Hefei.
authors.forename: S R
authors.initials: SR
authors.lastname: Cai
authors.forename: L C
authors.initials: LC
authors.lastname: Wang
authors.forename: D H
authors.initials: DH
authors.lastname: Kong
authors.forename: Z X
authors.initials: ZX
authors.lastname: Huang
authors.forename: R C
authors.initials: RC
authors.lastname: Ma
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001339:Autonomic Fibers, Preganglionic / Q000737:chemistry* / Q000502:physiology; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000502:physiology; D051381:Rats; D011941:Receptors, Adrenergic / Q000032:analysis*; D011985:Receptors, Serotonin / Q000032:analysis*; D013116:Spinal Cord / Q000737:chemistry* / Q000502:physiology
chemical_list: D011941:Receptors, Adrenergic; D011985:Receptors, Serotonin