[Genetic analysis of familial hypertension].
In order to study the genetic mode of familial hepertension, 63 pedigreses, including 140 nuclear pedigrees, of familial hypertension were investigated by means of pedigreed analysis and segregative analysis. Pedigreed analysis revealed that there is an evident phenomenon of vertical transmission in familial hypertension. It is hypothesed that there is a segregative ratio of dominant inheritance in A x U and A x A marital types, which is supported by segregative analysis. The data obtained suggest that the familial hypertension is an autosomal dominant hereditary disease. It is suggested that the genetic modes of familial hypertension could be different according to the different marital types of the patients. This finding suggests that the disease has a genetic heterogeneity. The research results will provide the reference evidence for the prevention, treatment and diagnosis of familial hypertension.
Sun
D
D
Jinan Central Hospital.
Hu
W
W
Zhu
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D005192:Family Health; D005260:Female; D018740:Genetic Heterogeneity; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010375:Pedigree