[Influence of genetic variation at apoprotein A-1 gene promoter region on plasma lipid levels in heart transplantation patients].
BACKGROUND
To study if the presence of the G/A polymorphism at the apo A-I gene promoter region could determine the lipid profile in patients with hyperlipidemia after heart transplantation, or if it is related with the type of heart disease that determined the transplantation.


METHODS
This study included 31 patients with hyperlipidemia after heart transplantation. Anthropometric parameters, basic analytic and lipid study were measured in these subjects. Identification of the G/A mutation in the promoter region of the apo A-I gene was performed.


RESULTS
22 patients had the G/G genotype and 9 the G/A. 14 were transplanted by coronary heart disease and 17 by non ischemic heart disease. Patients with the A allele had higher cHDL (63 [SD 15] vs 53 [10]; p = 0.034) and apo A-I plasma levels (156 [34] vs 132 [24]; p = 0.040) than G/G subjects. The A allele was present in the 18% of the patients transplanted by ischemic heart disease and in the 43% of the transplanted by another etiology (p = 0.073).


CONCLUSIONS
The presence of the G/A genotype in the promoter region of the apo A-I gene determines higher plasma levels of cHDL in patients with hyperlipidemia after heart transplantation.
González Amieva
A
A
Unidad de Lípidos y Arteriosclerosis, Hospital Universitario Reina Sofía, Córdoba.
Zambrana
J L
JL
López-Granados
A
A
Concha
M
M
López Miranda
J
J
Blanco Molina
A
A
Jiménez Perepérez
J A
JA
Pérez Jiménez
F
F
D000328:Adult; D000483:Alleles; D016632:Apolipoprotein A-I / Q000235:genetics*; D005260:Female; D005838:Genotype; D016027:Heart Transplantation; D006801:Humans; D006949:Hyperlipidemias / Q000175:diagnosis; D016014:Linear Models; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic
D016632:Apolipoprotein A-I; D008055:Lipids