title: Photodynamic therapy for corneal neovascularization.
abstract: OBJECTIVE
  Photodynamic therapy with tin ethyl etiopurpurin (SnET2) was evaluated as a treatment modality for rat corneal neovascularization.
  
  
  METHODS
  Escalating light doses at 664 nm were applied focally to corneal neovascularization in rats 10 minutes following an intravenous injection of SnET2 using a low-power diode laser. Controls consisted of light-only and drug-only treatments. Clinical, angiographic, and histopathologic evaluations were performed on the animals up to 28 days after drug and/or light treatment.
  
  
  RESULTS
  A drug and light dose-response was seen in producing neovessel closure. In animals treated with SnET2 and the highest light dose (25 J/cm2), all eyes showed occlusion at every follow-up evaluation up to 28 days. Control eyes demonstrated progressive disease at all time points.
  
  
  CONCLUSIONS
  Photodynamic therapy appears to be safe and effective for eliciting prolonged (> 28 days) occlusion of corneal neovascularization in the rat model with minimal side effects and good clinical outcomes.
authors.affiliation: Jules Stein Eye Institute, University of California at Los Angeles, USA.
authors.forename: G B
authors.initials: GB
authors.lastname: Primbs
authors.forename: R
authors.initials: R
authors.lastname: Casey
authors.forename: K
authors.initials: K
authors.lastname: Wamser
authors.forename: W J
authors.initials: WJ
authors.lastname: Snyder
authors.forename: D H
authors.initials: DH
authors.lastname: Crean
mesh_terms: D000818:Animals; D016510:Corneal Neovascularization / Q000188:drug therapy* / Q000473:pathology; D004195:Disease Models, Animal; D004307:Dose-Response Relationship, Radiation; D005451:Fluorescein Angiography / Q000379:methods; D008297:Male; D018715:Microscopy, Video / Q000379:methods; D010778:Photochemotherapy / Q000379:methods*; D011166:Porphyrins / Q000627:therapeutic use; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D011166:Porphyrins; D011838:Radiation-Sensitizing Agents; C063166:tin etiopurpurin