Ambiguus nucleus neurons innervating the abdominal esophagus are malpositioned in the reeler mouse.
To examine whether the migration of ambiguus nucleus (NA) neurons is affected in the reeler mouse, recombinant replication-deficient adenoviral vector carrying E. coli-galactosidase gene (lacZ) was injected into the abdominal esophagus of the reeler mouse and normal control at two months of age prior to 5 days of sacrifice of the animals. In the normal control, lacZ-positive neurons were found in the compact formation of the NA, whereas, in the reeler, they were scattered from the base of the fourth ventricle to the ventro-lateral margin of the medulla. The present study confirmed that NA neurons are malpositioned in the reeler mouse, suggesting that the migration of NA neurons is guided by the reelin-related protein (Reelin).
Fujimoto
Y
Y
Department of Anatomy and Embryology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo 183-8526, Japan.
Setsu
T
T
Ikeda
Y
Y
Miwa
A
A
Okado
H
H
Terashima
T
T
D000005:Abdomen / Q000294:innervation*; D000256:Adenoviridae / Q000235:genetics; D000818:Animals; D002465:Cell Movement / Q000502:physiology; D004926:Escherichia coli / Q000235:genetics; D004947:Esophagus / Q000294:innervation*; D005696:Galactosidases / Q000235:genetics; D005822:Genetic Vectors; D007763:Lac Operon; D008526:Medulla Oblongata / Q000166:cytology*; D051379:Mice; D008818:Mice, Neurologic Mutants; D009046:Motor Neurons / Q000473:pathology*; D000091042:Reelin Protein; D014779:Virus Replication
D000091042:Reelin Protein; D005696:Galactosidases; C000717128:Reln protein, mouse