Lack of R117H mutation in the cationic trypsinogen gene in patients with tropical pancreatitis from Bangladesh.
The etiology of nonalcoholic chronic pancreatitis, occurring in tropical regions, is unknown. Although environmental factors may play a role in its pathogenesis, a specific genetic predisposition may be necessary. The genetic mutation responsible for hereditary pancreatitis was described recently. Unlike in patients with hereditary pancreatitis, we found a lack of the R117H mutation in the cationic trypsinogen gene in all patients with tropical pancreatitis from Bangladesh.
Rossi
L
L
Research Division, Bangladesh Institute of Research & Rehabilitation in Diabetes, Endocrine & Metabolic Disorders, Dhaka.
Whitcomb
D C
DC
Ehrlich
G D
GD
Gorry
M C
MC
Parvin
S
S
Sattar
S
S
Ali
L
L
Azad Khan
A K
AK
Gyr
N
N
D000293:Adolescent; D000328:Adult; D001459:Bangladesh; D002908:Chronic Disease; D004247:DNA / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D010195:Pancreatitis / Q000235:genetics*; D017354:Point Mutation; D014329:Tropical Climate; D014362:Trypsinogen / Q000235:genetics*
D014362:Trypsinogen; D004247:DNA