title: Interleukin-1.
abstract: Interleukin 1 (IL1) is a primary regulator of inflammatory and immune responses. Via its type I receptor it activates specific protein kinases, including the NF kappa B inducing kinase (NIK) and three distinct mitogen-activated protein (MAP) kinase cascades. These modulate a number of transcription factors including NF kappa B, AP1 and CREB each of which regulate a plethora of immediate early genes central to the inflammatory response. Phase I clinical trials of the soluble type I receptor and IRAP indicate that these have potential anti-inflammatory effects.
authors.affiliation: School of Medical and Surgical Sciences, University Hospital, Queen's Medical Centre, Nottingham, UK. stylianou@nottingham.ac.uk
authors.forename: E
authors.initials: E
authors.lastname: Stylianou
authors.forename: J
authors.initials: J
authors.lastname: Saklatvala
mesh_terms: D033961:Adaptor Protein Complex 1; D033965:Adaptor Protein Complex alpha Subunits; D033942:Adaptor Proteins, Vesicular Transport; D000818:Animals; D050882:CREB-Binding Protein; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000096:biosynthesis*; D004790:Enzyme Induction; D017781:Genes, Immediate-Early; D007249:Inflammation / Q000188:drug therapy; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1 / Q000502:physiology*; D008565:Membrane Proteins / Q000096:biosynthesis; D016328:NF-kappa B / Q000096:biosynthesis*; D009687:Nuclear Proteins / Q000096:biosynthesis; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors / Q000502:physiology*; D011994:Recombinant Proteins / Q000627:therapeutic use; D012795:Sialoglycoproteins / Q000627:therapeutic use; D015534:Trans-Activators / Q000096:biosynthesis
chemical_list: D033961:Adaptor Protein Complex 1; D033965:Adaptor Protein Complex alpha Subunits; D033942:Adaptor Proteins, Vesicular Transport; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D008565:Membrane Proteins; D016328:NF-kappa B; D009687:Nuclear Proteins; D017472:Receptors, Interleukin-1; D011994:Recombinant Proteins; D012795:Sialoglycoproteins; D015534:Trans-Activators; D050882:CREB-Binding Protein; D017871:Calcium-Calmodulin-Dependent Protein Kinases