title: A prospective study of bone loss in menopausal Australian-born women.
abstract: Two hundred and twenty-four women (74 pre-, 90 peri-, 60 post-menopausal), aged 46-59 years, from a population-based cohort participated in a longitudinal study of bone mineral density (BMD). BMD was measured by dual-energy X-ray absorptiometry (DXA) at the lumbar spine and femoral neck and the time between bone scans was on average 25 (range 14-41) months. The aim of the study was to assess changes in BMD in relation to changes in normal menopausal status. During the study period women who were between 3 and 12 months past their last menstrual period (n = 22, late perimenopausal) at the time of the second bone scan had a mean (SE) annual change in BMD of -0.9% (0.4%) at the lumbar spine and -0.7% (0.6%) at the femoral neck (both p < 0.05 compared with women who remained premenopausal). In the women who became postmenopausal (n = 42) the mean annual changes in BMD were -2.5% (0.2%) at the lumbar spine and -1.7% (0.2%) at the femoral neck (both p < 0.0005), and in the women who remained post-menopausal (n = 60) they were -0.7% (0.2%) per year and -0.5% (0.3%) per year respectively (both p < 0.05), compared with women who remained premenopausal. In the 1-3 years after the final menstrual period (FMP) there was greater bone loss from the lumbar spine than the femoral neck (p < 0.05). In women who were menstruating at the time of the second bone scan and whose FMP could be dated prospectively (n = 35), higher baseline oestradiol levels were associated with less lumbar spine bone loss (p < 0.005). In the women who remained postmenopausal there was an association between baseline body mass index (BMI) and percentage change per year in femoral neck BMD (p < 0.05), such that women with higher BMI had less bone loss. In conclusion, during the time of transition from peri- to post-menopause, women had accelerated BMD loss at both the hip and spine.
authors.affiliation: Department of Psychiatry, Royal Melbourne Hospital, Victoria, Australia. j.guthrie@medicine.unimelb.edu.au
authors.forename: J R
authors.initials: JR
authors.lastname: Guthrie
authors.forename: P R
authors.initials: PR
authors.lastname: Ebeling
authors.forename: J L
authors.initials: JL
authors.lastname: Hopper
authors.forename: E
authors.initials: E
authors.lastname: Barrett-Connor
authors.forename: L
authors.initials: L
authors.lastname: Dennerstein
authors.forename: E C
authors.initials: EC
authors.lastname: Dudley
authors.forename: H G
authors.initials: HG
authors.lastname: Burger
authors.forename: J D
authors.initials: JD
authors.lastname: Wark
mesh_terms: D015502:Absorptiometry, Photon; D001315:Australia; D015992:Body Mass Index; D015519:Bone Density; D004958:Estradiol / Q000097:blood; D005260:Female; D006615:Hip / Q000503:physiopathology; D006801:Humans; D008019:Life Style; D008297:Male; D008598:Menstruation; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000097:blood / Q000208:ethnology / Q000503:physiopathology*; D011446:Prospective Studies; D013131:Spine / Q000503:physiopathology
chemical_list: D004958:Estradiol