Skeletal muscle UCP2 and UCP3 gene expression in a rat cancer cachexia model.
Rats bearing the Yoshida AH-130 ascites hepatoma showed an increased expression of both uncoupling protein-2 (UCP2) (194%) and UCP3 (189%) mRNA levels in skeletal muscle 7 days after tumour inoculation. Interestingly, an even greater increase was observed in mRNA for both UCP2 (278%) and UCP3 (797%) in the pair-fed animals, suggesting that the increase in gene expression was the result of the anorexia associated with tumour burden. The results constitute the first report of UCP2 and UCP3 gene expression during cancer cachexia and agree to their possible role in the increase of energy expenditure associated with tumour growth.
Sanchís
D
D
Centre National de la Recherche Scientifique, UPR 9078, Meudon, France.
Busquets
S
S
Alvarez
B
B
Ricquier
D
D
López-Soriano
F J
FJ
Argilés
J M
JM
D000273:Adipose Tissue / Q000473:pathology; D000818:Animals; D001835:Body Weight; D002100:Cachexia / Q000209:etiology / Q000378:metabolism*; D002352:Carrier Proteins / Q000235:genetics*; D002149:Energy Intake; D015972:Gene Expression Regulation, Neoplastic; D007473:Ion Channels; D008114:Liver Neoplasms, Experimental / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D026901:Membrane Transport Proteins; D024101:Mitochondrial Proteins; D018482:Muscle, Skeletal / Q000378:metabolism* / Q000473:pathology; D009929:Organ Size; D011506:Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D014158:Transcription, Genetic; D014475:Uncoupling Agents; D000071246:Uncoupling Protein 2; D000071247:Uncoupling Protein 3
D002352:Carrier Proteins; D007473:Ion Channels; D026901:Membrane Transport Proteins; D024101:Mitochondrial Proteins; D011506:Proteins; D012333:RNA, Messenger; C000604391:Ucp2 protein, rat; C000604394:Ucp3 protein, rat; D014475:Uncoupling Agents; D000071246:Uncoupling Protein 2; D000071247:Uncoupling Protein 3