HLA and HPA typing in idiopathic thrombocytopenic purpura patients treated with Kami-kihi-to.
We performed human leukocyte antigen (HLA) and human platelet antigen (HPA) in patients with Kami-kihi-to-responsive idiopathic thrombocytopenic purpura. The HLA-A2, A61 and Cw1 were significantly increased in responders compared with nonresponders, as were HLA DRB1 *0901, DRB1 *1502, and DPB1 *0501. In contrast, HLA DPB1 *0201 and DPB1 *0901 were significantly decreased in responders. The a/b genotype of HPA-2 and a/a genotype of HPA-3 were markedly increased in nonresponders, and anti-GPIb antibody was also increased. These results suggest that HLA, HPA, and anti-GP antibody studies may predict the response of idiopathic thrombocytopenic purpura to Kami-kihi-to.
Matsuzaki
T
T
Department of Blood Transfusion, Kansai Medical University, Osaka, Japan.
Nomura
S
S
Yamaoka
M
M
Ozaki
Y
Y
Yoshimura
C
C
Xie
G L
GL
Katsura
K
K
Kagawa
H
H
Ishida
T
T
Fukuhara
S
S
D016824:Antigens, Human Platelet / Q000145:classification* / Q000235:genetics; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006680:HLA Antigens / Q000145:classification* / Q000235:genetics; D015789:HLA-A2 Antigen / Q000145:classification / Q000235:genetics; D015235:HLA-B Antigens / Q000145:classification / Q000235:genetics; D015236:HLA-C Antigens / Q000145:classification / Q000235:genetics; D006684:HLA-DR Antigens / Q000145:classification / Q000235:genetics; D059811:HLA-DRB1 Chains; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000188:drug therapy / Q000276:immunology*
D016824:Antigens, Human Platelet; D004365:Drugs, Chinese Herbal; D006680:HLA Antigens; D015789:HLA-A2 Antigen; D015235:HLA-B Antigens; C079077:HLA-B61 antigen; D015236:HLA-C Antigens; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains