Exercise and the Marfan syndrome.
The Marfan syndrome is a heritable disorder of connective tissue affecting approximately one in 5000 to one in 10,000 individuals. The manifestations of the Marfan syndrome primarily involve the cardiovascular, musculoskeletal, and ocular systems. Aortic dilatation and dissection are the major causes of morbidity and mortality in the Marfan syndrome. The person with Marfan syndrome is often tall and agile and may unknowingly participate in certain physical activities and sports, putting himself or herself at risk for aortic dissection and sudden death. With appropriate diagnosis and treatment, the person with the Marfan syndrome can expect to live a long life. This article will review the diagnosis, genetics, clinical manifestations, and medical and surgical management of the Marfan syndrome. Guidelines for physical activity and exercise for the person with Marfan syndrome will be presented.
Braverman
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AC
Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. Abraverm@imgate.wustl.edu
D001018:Aortic Diseases / Q000503:physiopathology; D001019:Aortic Rupture / Q000503:physiopathology; D003645:Death, Sudden / Q000209:etiology; D004108:Dilatation, Pathologic / Q000503:physiopathology; D015444:Exercise / Q000502:physiology*; D005128:Eye Diseases / Q000503:physiopathology; D005260:Female; D006331:Heart Diseases / Q000503:physiopathology; D006801:Humans; D008297:Male; D008382:Marfan Syndrome / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology* / Q000601:surgery / Q000628:therapy; D009140:Musculoskeletal Diseases / Q000503:physiopathology; D012307:Risk Factors; D013177:Sports / Q000502:physiology*