Cholinergic excitation induces activity-dependent electrophysiological and transcriptional responses in hippocampal slices.
To explore the correlations between short-term neurophysiological events initiated by over-activation of acetylcholine receptors, and long-lasting changes in brain function, we combined electrophysiology and PCR-based measurements in hippocampal slices or live mice subjected to stress or drug-induced cholinergic activation. Our findings reveal a common cascade of neuronal events resulting in delayed suppression of cholinergic transmission.
Friedman
A
A
Department of Physiology, Faculty of Health Sciences, Ben Gurion University, Beersheva, Israel.
Kaufer
D
D
Pavlovsky
L
L
Soreq
H
H
D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D066298:In Vitro Techniques; D051379:Mice; D011976:Receptors, Muscarinic / Q000502:physiology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013312:Stress, Physiological / Q000378:metabolism; D014158:Transcription, Genetic / Q000187:drug effects*
D002800:Cholinesterase Inhibitors; D011976:Receptors, Muscarinic