title: Brugada syndrome associated with an autonomic disorder.
abstract: A 44 year old man with Brugada syndrome and ventricular fibrillation had an autonomic disorder, shown by spectral analysis of heart rate variability and 123I-MIBG myocardial scintigraphy. Periodic variation of the ST segments was detected by Holter ECG. Increased high frequency power (0.15-0.40 Hz), an index of parasympathetic nerve activity, was observed just before ST segment elevation. In addition, local dysfunction of sympathetic nerves in the left ventricle was detected by 123I-MIBG myocardial scintigraphy. Unbalanced autonomic nerve function plays an important role in inducing Brugada-type ECG signs.
authors.affiliation: Second Department of Internal Medicine, School of Medicine, University of Tokushima, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nomura
authors.forename: T
authors.initials: T
authors.lastname: Nada
authors.forename: J
authors.initials: J
authors.lastname: Endo
authors.forename: Y
authors.initials: Y
authors.lastname: Kondo
authors.forename: M
authors.initials: M
authors.lastname: Yukinaka
authors.forename: K
authors.initials: K
authors.lastname: Saito
authors.forename: S
authors.initials: S
authors.lastname: Ito
authors.forename: H
authors.initials: H
authors.lastname: Mori
authors.forename: Y
authors.initials: Y
authors.lastname: Nakaya
authors.forename: H
authors.initials: H
authors.lastname: Shinomiya
mesh_terms: D000328:Adult; D001341:Autonomic Nervous System / Q000503:physiopathology*; D001342:Autonomic Nervous System Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002037:Bundle-Branch Block / Q000000981:diagnostic imaging / Q000503:physiopathology*; D015716:Electrocardiography, Ambulatory; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012815:Signal Processing, Computer-Assisted; D013577:Syndrome; D014693:Ventricular Fibrillation / Q000000981:diagnostic imaging / Q000503:physiopathology*
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals