Malignant peripheral nerve sheath tumor of the pancreas with perineurial cell differentiation.
The authors report a malignant peripheral nerve sheath tumor (MPNST) that developed in the body of the pancreas of a 76-year-old woman. The well-demarcated tumor, 4.5 x 3.5 cm in size, was composed of spindle-shaped cells arranged in a storiform pattern or sweeping fascicles. Ultrastructurally, the tumor cells had elongated cytoplasmic processes with numerous pinocytotic vesicles, and were covered with discontinuous basal lamina-like substances. Immunohistochemically, tumor cells were diffusely positive for epithelial membrane antigen, vimentin, and CD34, but negative for S-100 protein and Leu 7. It was therefore concluded that the tumor was a MPNST with perineurial cell differentiation. Primary MPNST of the pancreas is extremely rare and the immunohistochemical and ultrastructural studies are necessary for its diagnosis.
Hirose
T
T
First Department of Pathology, University of Tokushima School of Medicine, Japan.
Maeda
T
T
Furuya
K
K
Kiyasu
Y
Y
Kawasaki
H
H
D000368:Aged; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018317:Nerve Sheath Neoplasms; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000648:ultrastructure; D010525:Peripheral Nerves / Q000473:pathology*; D010524:Peripheral Nervous System Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000648:ultrastructure; D014057:Tomography, X-Ray Computed