title: Inhibitors of enzymes of androgen biosynthesis: cytochrome P450(17) alpha and 5 alpha-steroid reductase.
authors.affiliation: Cancer Research Campaign Centre for Cancer Therapeutics, Institute of Cancer Research, Surrey, UK.
authors.forename: M
authors.initials: M
authors.lastname: Jarman
authors.forename: H J
authors.initials: HJ
authors.lastname: Smith
authors.forename: P J
authors.initials: PJ
authors.lastname: Nicholls
authors.forename: C
authors.initials: C
authors.lastname: Simons
mesh_terms: D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000378:metabolism*; D058891:5-alpha Reductase Inhibitors; D000728:Androgens / Q000096:biosynthesis*; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000201:enzymology / Q000378:metabolism; D013254:Steroid 17-alpha-Hydroxylase / Q000037:antagonists & inhibitors* / Q000378:metabolism*
chemical_list: D058891:5-alpha Reductase Inhibitors; D000728:Androgens; D065607:Cytochrome P-450 Enzyme Inhibitors; D004791:Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System; D013254:Steroid 17-alpha-Hydroxylase; C022433:pregnenolone 17-alpha-hydroxylase; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase