title: Dosimetric properties of a novel brachytherapy balloon applicator for the treatment of malignant brain-tumor resection-cavity margins.
abstract: OBJECTIVE
  This paper characterizes the dosimetric properties of a novel balloon brachytherapy applicator for the treatment of the tissue surrounding the resection cavity of a malignant brain tumor.
  
  
  METHODS
  The applicator consists of an inflatable silicone balloon reservoir attached to a positionable catheter that is intraoperatively implanted into the resection cavity and postoperatively filled with a liquid radionuclide solution. A simple dosimetric model, valid in homogeneous media and based on results from Monte Carlo photon-transport simulations, was used to determine the dosimetric characteristics of spherical geometry balloons filled with photon-emitting radionuclide solutions. Fractional depth-dose (FDD) profiles, along with activity densities, and total activities needed to achieve specified dose rates were studied as a function of photon energy and source-containment geometry. Dose-volume histograms (DVHs) were calculated to compare idealized balloon-applicator treatments to conventional 125I seed volume implants.
  
  
  RESULTS
  For achievable activity densities and total activities, classical low dose rate (LDR) treatments of residual disease at distances of up to 1 cm from the resection cavity wall are possible with balloon applicators having radii between 0.5 cm and 2.5 cm. The dose penetration of these applicators increases approximately linearly with balloon radius. The FDD profile can be made significantly more or less penetrating by combining selection of radionuclide with source-geometry manipulation. Comparisons with 125I seed-implant DVHs show that the applicator can provide a more conformal therapy with no target tissue underdosing, less target tissue overdosing, and no healthy tissue "hot spots;" however, more healthy tissue volume receives a dose of the prescribed dosage or less.
  
  
  CONCLUSIONS
  This device, when filled with 125I solution, is suitable for classical LDR treatments and may be preferable to 125I interstitial-seed implants in several respects. Manipulation of the dosimetric properties of the device can improve its characteristics for brain tumor treatment and may make it suitable for boosting the lumpectomy margins in conservative breast cancer treatment.
authors.affiliation: Radiation Oncology Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors.forename: J F
authors.initials: JF
authors.lastname: Dempsey
authors.forename: J A
authors.initials: JA
authors.lastname: Williams
authors.forename: J B
authors.initials: JB
authors.lastname: Stubbs
authors.forename: T J
authors.initials: TJ
authors.lastname: Patrick
authors.forename: J F
authors.initials: JF
authors.lastname: Williamson
mesh_terms: D001918:Brachytherapy / Q000295:instrumentation*; D001932:Brain Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D002404:Catheterization / Q000295:instrumentation; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D018365:Neoplasm, Residual; D011879:Radiotherapy Dosage
chemical_list: D007457:Iodine Radioisotopes