[The dehydrating action of ketamine on malignant breast tumors].
The study has been concerned with the influence of the anesthetic drug--ketamine--on hydration processes in normal and tumor glandular tissues as well as the binding of labeled ouabain to tissues, to assay the levels of NaK molecules of ATFase on cell membrane. Cell hydration declined during their incubation with Tyrode's solution-based narcotic and subnarcotic doses of ketamine. Also, a sharp drop in the binding ability of 10(-8) M of 3H-ouabain was observed after tumor tissue incubation with ketamine, which served as another indicator of cell shrinkage. It is suggested that tumor cell hydration level is relatively high and subnarcotic doses of ketamine produce a discriminate effect on tumor tissue.
Danielian
A A
AA
Biophysical Center, National Academy of Sciences of Armenia, Research Institute of Oncology of the Health Ministry of the Republic of Armenia.
Mirakian
M M
MM
Aĭrapetian
S N
SN
D000778:Anesthetics, Dissociative / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D003681:Dehydration / Q000378:metabolism; D005260:Female; D006801:Humans; D007649:Ketamine / Q000494:pharmacology*; D010042:Ouabain / Q000378:metabolism
D000778:Anesthetics, Dissociative; D010042:Ouabain; D007649:Ketamine