title: Mouse Brachyury the Second (T2) is a gene next to classical T and a candidate gene for tct.
abstract: The mouse Brachyury the Second (T2) gene is 15 kb away from classical Brachyury (T). A mutation in T2 disrupts notochord development, pointing to the existence of a second T/t complex gene involved in axis development. T2 encodes a novel protein that is disrupted by an insertion in T2(Bob) mice. Sequence analysis of T2 from several t haplotypes shows that they all share the same changed stop codon, and, thus, T2 is a candidate gene for the t complex tail interaction factor. T1, T2, and the unlinked t-int are distinct and unrelated loci, and mutations in these genes do not complement one another genetically. Either their products interact in the same pathway during the genesis of the embryonic axis, or the T/t region itself is truly complex.
authors.affiliation: The Institute for Cellular and Molecular Biology, Department of Microbiology, The University of Texas, Austin, Texas 78712-1064, USA.
authors.forename: G
authors.initials: G
authors.lastname: Rennebeck
authors.forename: E
authors.initials: E
authors.lastname: Lader
authors.forename: A
authors.initials: A
authors.lastname: Fujimoto
authors.forename: E P
authors.initials: EP
authors.lastname: Lei
authors.forename: K
authors.initials: K
authors.lastname: Artzt
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D018076:DNA, Complementary / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D005326:Fetal Proteins; D016678:Genome; D051379:Mice; D008969:Molecular Sequence Data; D020825:T-Box Domain Proteins; D014157:Transcription Factors / Q000235:genetics*; D000098908:Brachyury Protein
chemical_list: D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D005326:Fetal Proteins; D020825:T-Box Domain Proteins; D014157:Transcription Factors; D000098908:Brachyury Protein