Familial sick sinus syndrome with atrioventricular conduction disturbance.
A family with sick sinus syndrome is presented: a mother and her 2 daughters affected with sinus node dysfunction. Electrophysiological studies revealed abnormal atrioventricular conduction in the 2 daughters. All 3 individuals were implanted with a permanent pacemaker to relieve their symptoms. Endomyocardial biopsy from the right ventricle of one daughter showed disarrangement, degeneration, myocyte necrosis and interstitial fibrosis suggestive of myocardial disease.
Isobe
M
M
First Department of Internal Medicine, Shinshu University, School of Medicine, Matsumoto, Japan.
Oka
T
T
Takenaka
H
H
Imamura
H
H
Kinoshita
O
O
Kasanuki
H
H
Sekiguchi
M
M
D000328:Adult; D002648:Child; D005190:Family; D005260:Female; D020022:Genetic Predisposition to Disease; D006327:Heart Block; D006801:Humans; D008875:Middle Aged; D010138:Pacemaker, Artificial; D012804:Sick Sinus Syndrome / Q000235:genetics* / Q000503:physiopathology* / Q000628:therapy