title: Fibrinogen and fibrinolysis in blood and in the arterial wall: its role in advanced atherosclerotic disease.
abstract: High plasma fibrinogen appears to be an important risk factor for the development of atherosclerosis. The aim of our study was to measure fibrinogen and fibrin degradation products (D-dimer), interleukin-6 tissue plasminogen activator, plasminogen activator inhibitor-1 and urokinase-type plasminogen activator in the plasma and arterial walls of 45 patients who had arterial surgery between April 1993 and November 1995. The arterial specimens were also examined by immunohistochemists for these same factors. The serum fibrinogen and fibrin degradation products were high in all patients, and fibrinolysis was depressed. Few leukocytes were seen in the arterial walls, which had poor fibrinolytic activity. Plasminogen-activator inhibitor activity in the wall was also reduced in the affected arterial walls. The abdominal aorta appeared to have the highest levels of fibrinogen and this may be related to its ability to form aneurysms. Fibrinogen may play an important role in the progression of atherosclerotic disease.
authors.affiliation: University Hospital Joan XXIII, Tarragona, Spain.
authors.forename: V
authors.initials: V
authors.lastname: Martin-Paredero
authors.forename: J
authors.initials: J
authors.lastname: Vadillo
authors.forename: J
authors.initials: J
authors.lastname: Diaz
authors.forename: A
authors.initials: A
authors.lastname: Espinosa
authors.forename: C
authors.initials: C
authors.lastname: Berga
authors.forename: J
authors.initials: J
authors.lastname: Segura
authors.forename: J
authors.initials: J
authors.lastname: Sanchez
authors.forename: A
authors.initials: A
authors.lastname: Barbod
authors.forename: C
authors.initials: C
authors.lastname: Villaverde
authors.forename: C M
authors.initials: CM
authors.lastname: Richard
mesh_terms: D001012:Aorta, Abdominal; D001018:Aortic Diseases / Q000097:blood / Q000378:metabolism / Q000601:surgery; D001161:Arteriosclerosis / Q000097:blood* / Q000473:pathology / Q000601:surgery; D002340:Carotid Artery Diseases / Q000097:blood / Q000378:metabolism / Q000601:surgery; D016022:Case-Control Studies; D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005263:Femoral Artery; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism* / Q000502:physiology; D005342:Fibrinolysis; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000378:metabolism / Q000473:pathology; D016491:Peripheral Vascular Diseases / Q000097:blood / Q000378:metabolism / Q000601:surgery; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism; D011150:Popliteal Artery; D012307:Risk Factors; D014568:Urokinase-Type Plasminogen Activator / Q000378:metabolism
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D015850:Interleukin-6; D017395:Plasminogen Activator Inhibitor 1; C036309:fibrin fragment D; D005340:Fibrinogen; D014568:Urokinase-Type Plasminogen Activator