Delayed loss of p75 neurotrophin receptor-immunoreactivity in the rat suprachiasmatic nucleus and intergeniculate leaflet after binocular enucleation.
The rat suprachiasmatic nucleus (SCN) contains a dense plexus of low-affinity p75 neurotrophin receptor (p75NTR)-immunoreactivity. Scattered patches of p75NTR immunoreactivity are present in the intergeniculate leaflet (IGL). Both SCN and IGL receive a direct retinal input. After binocular enucleation, there is a delayed loss of p75NTR-immunoreactivity in the SCN and IGL beginning at, respectively, 4 and 8 weeks post-enucleation, with complete loss occurring in both nuclei by week 12. This delayed loss may be due to an up-regulation of growth factor secretion by local cells in response to retinal axon degeneration.
Moga
M M
MM
Department of Anatomy, Indiana University School of Medicine, Terre Haute 47809-9989, USA. mefmoga@thcme.indstate.edu
D000818:Animals; D000906:Antibodies / Q000378:metabolism; D000918:Antibody Specificity; D002940:Circadian Rhythm / Q000502:physiology; D015353:Eye Enucleation; D005829:Geniculate Bodies / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology; D007150:Immunohistochemistry; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D020800:Receptor, Nerve Growth Factor; D017475:Receptors, Nerve Growth Factor / Q000032:analysis / Q000378:metabolism*; D013493:Suprachiasmatic Nucleus / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology; D013997:Time Factors
D000906:Antibodies; D020800:Receptor, Nerve Growth Factor; D017475:Receptors, Nerve Growth Factor