Imipenem inhibits in vitro activity of amphotericin B directed against Aspergillus fumigatus.
A decrease of the susceptibility of Aspergillus fumigatus strains to amphotericin B was found when tested in combination with high concentrations (128-2048 mg/l) of the antibacterial agent imipenem by checkerboard titration and agar diffusion assay. Only bacteriologically active imipenem showed the antagonism. The mechanism of action is unknown. However, imipenem and amphotericin B did not react directly, as shown by checkerboard titration with bacterial strains as well as by HPLC analysis. It is concluded that imipenem medication may influence the efficacy of amphotericin B treatment in aspergillosis.
Rath
P M
PM
Institut für Medizinische Mikrobiologie, Universität-GH Essen, Germany.
Hülsewede
J W
JW
Ansorg
R
R
D000666:Amphotericin B / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000935:Antifungal Agents / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D001232:Aspergillus fumigatus / Q000187:drug effects*; D004336:Drug Antagonism; D015378:Imipenem / Q000494:pharmacology*; D013845:Thienamycins / Q000494:pharmacology*
D000935:Antifungal Agents; D013845:Thienamycins; D015378:Imipenem; D000666:Amphotericin B