title: Evaluation of treatment modalities for thoracic empyema: a cost-effectiveness analysis.
abstract: BACKGROUND
  Empyema thoracis is treated with a multitude of therapeutic options. Optimal therapy and cost-containment requires selection of the most appropriate initial intervention.
  
  
  METHODS
  A retrospective review of treatment modalities was performed on 77 patients diagnosed with empyema thoracis from 1990 to 1997 at one institution. Mean age was 59 years (range, 21 to 90 years); 52 were men and 25 were women.
  
  
  RESULTS
  Sixty-five percent (50/77) were parapneumonic and 68% (52/77) were multiloculated. Treatment modalities were as follows: group 1, antibiotics only (n = 4); group 2, primary intervention: image-directed catheter (n = 20) or tube thoracostomy (n = 24); and group 3, secondary intervention: decortication (n = 17), rib resection or muscle interposition (n = 12). Thirty-four percent (9/20 image-directed catheter and 8/24 tube thoracostomy) had failure of initial intervention. Patients undergoing decortication more often had multiloculated empyema thoracis (16 of 17) compared with those undergoing image-directed catheters (8 of 20) or tube thoracotomy (16 of 24). Length of stay was reduced for decortication patients (17 days) compared with those having image-directed catheters (21.8 days), failed image-directed catheters (29.7 days), or tube thoracostomies (19.6 days). Hospital charges per patient between decortication and image-directed catheter ($34,770.79 versus $37,869.41) were comparable, but charges were significantly decreased in decortication patients as compared with failed image-directed catheters ($55,609.32; p < 0.05).
  
  
  CONCLUSIONS
  Our series revealed that early decortication has charges similar to those of primary intervention (image-directed catheter or tube thoracostomy) but is more cost-effective than failed image-directed catheter. We advocate the use of early surgical intervention as the most optimal and cost-effective initial modality for the treatment of empyema thoracis.
authors.affiliation: Division of Cardiothoracic Surgery, Emory University School of Medicine, Atlanta, GA, USA.
authors.forename: V H
authors.initials: VH
authors.lastname: Thourani
authors.forename: K M
authors.initials: KM
authors.lastname: Brady
authors.forename: K A
authors.initials: KA
authors.lastname: Mansour
authors.forename: J I
authors.initials: JI
authors.lastname: Miller
authors.forename: R B
authors.initials: RB
authors.lastname: Lee
mesh_terms: D000900:Anti-Bacterial Agents / Q000191:economics / Q000627:therapeutic use; D003362:Cost-Benefit Analysis; D004322:Drainage / Q000191:economics; D016724:Empyema, Pleural / Q000191:economics* / Q000453:epidemiology / Q000628:therapy*; D005260:Female; D017722:Hospital Charges / Q000706:statistics & numerical data; D006801:Humans; D007902:Length of Stay / Q000191:economics; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D019616:Thoracic Surgical Procedures / Q000191:economics; D013907:Thoracostomy / Q000191:economics; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents