title: Pulpal response to a resin-modified glass-ionomer material on nonexposed and exposed monkey pulps.
abstract: OBJECTIVE
  This study evaluated the biocompatibility of a resin-modified glass-ionomer material on monkey pulps.
  
  
  METHODS
  Standardized Class V cavities were prepared in 112 teeth distributed in six healthy adult monkeys. The resin-modified glass-ionomer cement was placed in 24 nonexposed and 36 exposed pulps according to manufacturer's instructions. ZOE was used as a control in nonexposed pulps, while calcium hydroxide was used as a control for exposed pulps. Tissues were collected at 6 to 7, 21 to 27, and 90 to 97 days. After demineralization, the teeth were serially sectioned, stained, and observed by light microscopy.
  
  
  RESULTS
  Except for one resin-modified glass-ionomer pulp at 6 days, there were no differences between the responses of nonexposed pulps to resin-modified glass-ionomer specimens and ZOE controls. In exposed pulps, eight of 36 resin-modified glass-ionomer pulps showed various grades of inflammatory response, all associated with stained bacteria. Pulpal healing was similar in both resin-modified glass-ionomer and calcium hydroxide direct-capped exposures. Twenty-two of 26 exposed pulps restored with the resin-modified glass-ionomer cement showed dentin bridge formation at 21 and 97 days.
  
  
  CONCLUSIONS
  The resin-modified glass-ionomer material exhibited acceptable biologic compatibility in exposed and nonexposed cavities.
authors.affiliation: Department of Conservative Dentistry, Faculty of Dentistry, Istanbul University, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Tarim
authors.forename: A A
authors.initials: AA
authors.lastname: Hafez
authors.forename: C F
authors.initials: CF
authors.lastname: Cox
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002126:Calcium Hydroxide / Q000494:pharmacology; D003188:Composite Resins / Q000494:pharmacology*; D003763:Dental Leakage; D003764:Dental Materials / Q000494:pharmacology; D003782:Dental Pulp / Q000187:drug effects*; D003785:Dental Pulp Capping / Q000009:adverse effects*; D003789:Dental Pulp Exposure / Q000628:therapy; D003793:Dental Restoration, Permanent / Q000379:methods; D005899:Glass Ionomer Cements / Q000494:pharmacology*; D008253:Macaca mulatta; D011671:Pulpitis / Q000139:chemically induced*; D015035:Zinc Oxide-Eugenol Cement / Q000494:pharmacology
chemical_list: D003188:Composite Resins; D003764:Dental Materials; D005899:Glass Ionomer Cements; C084550:Vitremer; D015035:Zinc Oxide-Eugenol Cement; C040408:Life (dental material); D002126:Calcium Hydroxide