title: Ambiguus nucleus neurons innervating the abdominal esophagus are malpositioned in the reeler mouse.
abstract: To examine whether the migration of ambiguus nucleus (NA) neurons is affected in the reeler mouse, recombinant replication-deficient adenoviral vector carrying E. coli-galactosidase gene (lacZ) was injected into the abdominal esophagus of the reeler mouse and normal control at two months of age prior to 5 days of sacrifice of the animals. In the normal control, lacZ-positive neurons were found in the compact formation of the NA, whereas, in the reeler, they were scattered from the base of the fourth ventricle to the ventro-lateral margin of the medulla. The present study confirmed that NA neurons are malpositioned in the reeler mouse, suggesting that the migration of NA neurons is guided by the reelin-related protein (Reelin).
authors.affiliation: Department of Anatomy and Embryology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo 183-8526, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Fujimoto
authors.forename: T
authors.initials: T
authors.lastname: Setsu
authors.forename: Y
authors.initials: Y
authors.lastname: Ikeda
authors.forename: A
authors.initials: A
authors.lastname: Miwa
authors.forename: H
authors.initials: H
authors.lastname: Okado
authors.forename: T
authors.initials: T
authors.lastname: Terashima
mesh_terms: D000005:Abdomen / Q000294:innervation*; D000256:Adenoviridae / Q000235:genetics; D000818:Animals; D002465:Cell Movement / Q000502:physiology; D004926:Escherichia coli / Q000235:genetics; D004947:Esophagus / Q000294:innervation*; D005696:Galactosidases / Q000235:genetics; D005822:Genetic Vectors; D007763:Lac Operon; D008526:Medulla Oblongata / Q000166:cytology*; D051379:Mice; D008818:Mice, Neurologic Mutants; D009046:Motor Neurons / Q000473:pathology*; D000091042:Reelin Protein; D014779:Virus Replication
chemical_list: D000091042:Reelin Protein; D005696:Galactosidases; C000717128:Reln protein, mouse