title: Identical twins with medulloblastoma occurring in infancy.
abstract: Familial cerebellar medulloblastomas occurred in monozygotic twin siblings during infancy, and they had a rapid downhill course. Both twins underwent surgery for the tumours. This was followed by chemotherapy in the second twin. Both died after a short time. The tumours were seen to arise from the cerebellum and both had almost identical histomorphological features. To the best of our knowledge, this is the second report of familial medulloblastoma in twin siblings. Our observation suggests an underlying genetic influence in the histogenesis of these tumours.
authors.affiliation: Department of Pathology, National Institute of Mental Health and Neurosciences, Madras, India.
authors.forename: B
authors.initials: B
authors.lastname: Chidambaram
authors.forename: V
authors.initials: V
authors.lastname: Santhosh
authors.forename: S K
authors.initials: SK
authors.lastname: Shankar
mesh_terms: D002528:Cerebellar Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology; D004200:Diseases in Twins; D006801:Humans; D007223:Infant; D008297:Male; D008527:Medulloblastoma / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014430:Twins, Monozygotic