The role of neuronal nicotinic acetylcholine receptors in antinociception: effects of ABT-594.
ABT-594, a nicotinic acetylcholine receptor agonist, has antinociceptive effects in rat models of acute thermal, persistent chemical, and neuropathic pain. Direct injection of ABT-594 into the nucleus raphe magnus (NRM) is antinociceptive in a thermal threshold test and destruction of serotonergic neurons in the NRM attenuates the effect of systemic ABT-594. However, lidocaine-inactivation of the NRM prevents the antinociceptive effect of systemic (-)-nicotine but not that of systemic ABT-594.
Decker
M W
MW
Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, IL 60064-3500, USA.
Curzon
P
P
Holladay
M W
MW
Nikkel
A L
AL
Bitner
R S
RS
Bannon
A W
AW
Donnelly-Roberts
D L
DL
Puttfarcken
P S
PS
Kuntzweiler
T A
TA
Briggs
C A
CA
Williams
M
M
Arneric
S P
SP
D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D001384:Azetidines / Q000494:pharmacology*; D004195:Disease Models, Animal; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D018722:Nicotinic Agonists / Q000494:pharmacology*; D010146:Pain / Q000188:drug therapy* / Q000503:physiopathology; D011725:Pyridines / Q000494:pharmacology*; D011903:Raphe Nuclei / Q000187:drug effects; D051381:Rats; D011978:Receptors, Nicotinic / Q000502:physiology*
C109763:5-(2-azetidinylmethoxy)-2-chloropyridine; D018712:Analgesics, Non-Narcotic; D001384:Azetidines; D018722:Nicotinic Agonists; D011725:Pyridines; D011978:Receptors, Nicotinic