title: Dental fluorosis in Chilean children: evaluation of risk factors.
abstract: The purpose of this case-control study was to determine the association between very-mild-to-moderate enamel fluorosis and exposure during early childhood to fluoridated water, mainly through ingestion of powdered milk. Analysis was performed on 136 residents of the optimally fluoridated community of San Felipe in the Chilean Fifth Region, who were categorised into one of three groups according to their age when water fluoridation was introduced in 1986: Group I was born after 1986; Group II was 16-24 months old in 1986; and Group III was >24 months of age. The case and control subjects were selected on the basis of a clinical examination given in July 1996. Dean's scoring system was used to determine fluorosis status. Risk factor exposure was ascertained by a questionnaire used in interviews with mothers of participating children. Logistic regression analysis, after adjustment for confounding variables, revealed that very-mild-to-moderate enamel fluorosis of permanent central maxillary incisors (CMI) was strongly associated both with the age of the subjects when water fluoridation began and with breast-feeding duration for children belonging to Group I. Subjects in Group I were 20.44 times more likely (95% CI: 5.00-93.48) to develop CMI fluorosis than children who were older than 24 months (Group III) when fluoridation began. Subjects who were between 16 and 24 months old when water fluoridation began were 4.15 times more likely (95% CI: 1.05-16.43) to have CMI fluorosis than children older than 24 months. An inverse association was found with breastfeeding duration (OR=0.86, 95% CI: 0.75-0.98) among Group I subjects but not in Groups II and III. Results obtained suggest that the current fluoride concentration in drinking water may be contributing to fluorosis. Further studies will be necessary to determine the relative competing risks of dental fluorosis and dental caries in Chilean children in order to establish the most appropriate water fluoridation level in Chile.
authors.affiliation: Institute of Nutrition and Food Technology, INTA, University of Chile, Santiago. avilla@uec.inta.uchile.cl
authors.forename: A E
authors.initials: AE
authors.lastname: Villa
authors.forename: S
authors.initials: S
authors.lastname: Guerrero
authors.forename: G
authors.initials: G
authors.lastname: Icaza
authors.forename: J
authors.initials: J
authors.lastname: Villalobos
authors.forename: M
authors.initials: M
authors.lastname: Anabalón
mesh_terms: D000704:Analysis of Variance; D001942:Breast Feeding; D002648:Child; D002675:Child, Preschool; D002677:Chile / Q000453:epidemiology; D005457:Fluoridation / Q000009:adverse effects*; D009050:Fluorosis, Dental / Q000453:epidemiology* / Q000209:etiology*; D006801:Humans; D007223:Infant; D016015:Logistic Models; D015995:Prevalence; D012307:Risk Factors; D011795:Surveys and Questionnaires; D013662:Tea / Q000009:adverse effects; D014100:Toothpastes / Q000009:adverse effects
chemical_list: D013662:Tea; D014100:Toothpastes