title: Acute human histopathology of an intracranial aneurysm treated using Guglielmi detachable coils: case report and review of the literature.
abstract: OBJECTIVE
  This case study provided us with the opportunity to explore the histopathological effects of Guglielmi detachable coil (GDC) therapy on the aneurysm orifice and parent vessel-aneurysm neck interface. This type of study is important to the understanding of the mechanisms of obliteration of aneurysms by GDCs.
  
  
  METHODS
  The patient presented with a Hunt and Hess Grade III subarachnoid hemorrhage that occurred secondary to the rupture of a small anterior communicating artery aneurysm.
  
  
  METHODS
  The aneurysm was successfully coiled without complication, but the patient died 36 hours later. We examined the gross and microscopic pathological findings of this GDC-treated anterior communicating artery aneurysm 36 hours after coiling. A discrete membrane composed of fibrin had formed completely across the aneurysm orifice, excluding the aneurysm sac from the circulation. This membrane was contiguous with the parent vessel.
  
  
  CONCLUSIONS
  This case represents one of the first examples in humans of the formation of a membrane over the aneurysm orifice after GDC therapy. The formation of this membrane, shown to be composed of fibrin, was found at 36 hours after coiling, which is the earliest time frame at which membrane formation has been noted in either humans or animal models. This fibrin membrane may function both as a scaffold for subsequent endothelialization across the aneurysm neck as well as to isolate the aneurysm from the parent circulation, permitting thrombus within the aneurysm sac to mature to an endovascular scar. The factors contributing to the formation of this membrane and its clinical implications are discussed.
authors.affiliation: Department of Surgery, The Toronto Hospital, Ontario, Canada.
authors.forename: S I
authors.initials: SI
authors.lastname: Stiver
authors.forename: P J
authors.initials: PJ
authors.lastname: Porter
authors.forename: R A
authors.initials: RA
authors.lastname: Willinsky
authors.forename: M C
authors.initials: MC
authors.lastname: Wallace
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002533:Cerebral Angiography; D004621:Embolization, Therapeutic / Q000295:instrumentation*; D004730:Endothelium, Vascular / Q000473:pathology*; D004867:Equipment Design; D017809:Fatal Outcome; D005260:Female; D005337:Fibrin / Q000648:ultrastructure*; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy
chemical_list: D005337:Fibrin