title: Correlation between the growth of uterine leiomyomata and estrogen and progesterone receptor content in needle biopsy specimens.
abstract: OBJECTIVE
  To examine the relationship between estrogen receptor (ER) and progesterone receptor (PR) content in needle biopsy specimens and the growth of uterine leiomyomata after biopsy.
  
  
  METHODS
  Prospective clinical study.
  
  
  METHODS
  University teaching hospital.
  
  
  METHODS
  Thirty-one women with uterine leiomyomata and a normal menstrual cycle.
  
  
  METHODS
  Transcervical needle biopsy of uterine leiomyomata.
  
  
  METHODS
  The relationships between histologic features (smooth muscle content, immunohistochemical expression of ER and PR) and the percent increase over a 12-month observation period in the volume of the largest myoma nodule measured by magnetic resonance imaging were analyzed.
  
  
  RESULTS
  Both the density and intensity of immunohistochemical staining of PRs in uterine leiomyoma tissue showed significant positive correlation with leiomyoma growth.
  
  
  CONCLUSIONS
  The growth of uterine leiomyomata can be determined by histologic and immunohistochemical analysis of needle biopsy specimens from uterine leiomyomata.
authors.affiliation: Department of Obstetrics and Gynecology, Osaka City University Medical School, Osaka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ichimura
authors.forename: N
authors.initials: N
authors.lastname: Kawamura
authors.forename: F
authors.initials: F
authors.lastname: Ito
authors.forename: S
authors.initials: S
authors.lastname: Shibata
authors.forename: K
authors.initials: K
authors.lastname: Minakuchi
authors.forename: A
authors.initials: A
authors.lastname: Tsujimura
authors.forename: N
authors.initials: N
authors.lastname: Umesaki
authors.forename: S
authors.initials: S
authors.lastname: Ogita
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D011446:Prospective Studies; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*; D014594:Uterine Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone