[Modulation mechanism of IL-1 in hemorrhagic shock in relation to endotoxin].
The modulation mechanism of IL-1 in relation to endotoxin (ET) was investigated in hemorrhangic shock rat. It was found that within 4 h after hemorrhagic shock, SD rat showed a significant increase in both ET and IL-1, the latter taking place earlier than the former. While SD rat reared in germ free condition showed an obvious increas in IL-1 but without marked change in ET, no matter whether the rats reared in different condition were pretreated with lactuolsc or anti-ET. Within 5 d after reinfusion of lost blood to the ordinary shock rat, IL-1 and ET changed in a parallel manner. When shock rats were treated with lactulose or anti-ET, both IL-1 and ET showed significant decrease as compared with the control. It is suggested from the above observation that ET is not an important factor in enhancing IL-1 activity in the early stage of hemorrhagic shock, but does contribute to the increased IL-1 activity in the later phase of hemorrhagic shock. The ET comes mainly from the gut in hemorrhagic state.
Shi
H P
HP
Department of General Surgery, South Hospital, First Military Medical University, Guangzhou.
Miao
M Y
MY
Qin
L P
LP
Gao
H
H
Xu
R B
RB
D000818:Animals; D004731:Endotoxins / Q000097:blood*; D005260:Female; D005856:Germ-Free Life / Q000502:physiology; D007375:Interleukin-1 / Q000097:blood*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D051381:Rats; D017208:Rats, Wistar; D012771:Shock, Hemorrhagic / Q000097:blood*
D004731:Endotoxins; D007375:Interleukin-1