CSF monoamine metabolites in relation to the diagnostic interview for borderline patients (DIB).
The cerebrospinal fluid concentrations of the monoamine metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), 3-methoxy-4-hydroxyphenylglycol, and their ratios were studied in relation to the Diagnostic Interview for Borderline patients (DIB) evaluated retrospectively from hospital records for a sample of 202 patients participating in psychobiological programs on mood disorders. No correlations with the total DIB score were significant. Patients with borderline personality disorder (BPD) defined by a total DIB score of at least 7 or 6, respectively, did not differ significantly from non-BPD regarding the metabolites. However, for section II (impulse action pattern) of the DIB, those with an intermediate value of the section score had significantly higher levels of 5-HIAA and HVA, suggesting that such higher than normal concentrations may be protective against impulsive or suicidal behavior generated by an underlying psychiatric morbidity due to other risk factors.
Chotai
J
J
Department of Psychiatry, University of Umeâ, Lycksele Hospital, Lycksele, Sweden.
Kullgren
G
G
Asberg
M
M
D015306:Biogenic Monoamines / Q000134:cerebrospinal fluid*; D001883:Borderline Personality Disorder / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000523:psychology; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D008734:Methoxyhydroxyphenylglycol / Q000134:cerebrospinal fluid; D019964:Mood Disorders / Q000134:cerebrospinal fluid; D011569:Psychiatric Status Rating Scales; D012189:Retrospective Studies
D015306:Biogenic Monoamines; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D006719:Homovanillic Acid