title: Pharmacokinetics of oxytetracycline in the red pacu (Colossoma brachypomum) following different routes of administration.
abstract: Oxytetracycline (OTC) pharmacokinetics were studied in the red pacu (Colossoma brachypomum) following intravenous (i.v.) and intramuscular (i.m.) administration at a dose of 5 mg/kg body weight. OTC plasma concentrations were determined by high-performance-liquid-chromatography (HPLC). A non-compartmental model was used to describe plasma drug disposition after OTC administration. Following i.m. administration, the elimination half-life (t1/2) was 62.65 +/- 1.25 h and the bioavailability was 49.80 +/- 0.01%. After i.v. administration the t1/2 was 50.97 +/- 2.99 h, the Vd was 534.11 +/- 38.58 mL/kg, and CI(b) was 0.121 +/- 0.003 mL/min x kg. The 5 mg/kg i.v. dose used in this experiment resulted in up to 48 h plasma concentrations of OTC above the reported MIC values for some strains of fish pathogens such as Aeromonas hydrophila, A. liquefaciens, A. salmonicida, Cytophaga columnaris, Edwardsiella ictaluri, Vibrio anguillarium, V. ordalii, V. salmonicida and Yeersinia ruckeri. These MIC values are below the susceptible range (4 microg/mL) listed by the National Committee for Clinical Laboratory Standards (NCCLS) as determined by the NCCLS susceptibility interpretive criteria.
authors.affiliation: Department of Companion Animal and Special Species Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Doi
authors.forename: M K
authors.initials: MK
authors.lastname: Stoskopf
authors.forename: G A
authors.initials: GA
authors.lastname: Lewbart
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001682:Biological Availability; D005399:Fishes / Q000502:physiology*; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D010118:Oxytetracycline / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012016:Reference Values
chemical_list: D000900:Anti-Bacterial Agents; D010118:Oxytetracycline