Bactericidal activities of the pyrrole derivative BM212 against multidrug-resistant and intramacrophagic Mycobacterium tuberculosis strains.
The pyrrole derivative BM212 [1, 5-diaryl-2-methyl-3-(4-methylpiperazin-1-yl)methyl-pyrrole] was shown to possess strong inhibitory activity against both Mycobacterium tuberculosis and some nontuberculosis mycobacteria. BM212 was inhibitory to drug-resistant mycobacteria and also exerted bactericidal activity against intracellular bacilli residing in the U937 human histiocytic lymphoma cell line.
Deidda
D
D
Dipartimento di Scienze Mediche, Cattedra di Microbiologia, Università di Cagliari, Cagliari, Italy.
Lampis
G
G
Fioravanti
R
R
Biava
M
M
Porretta
G C
GC
Zanetti
S
S
Pompei
R
R
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018432:Drug Resistance, Multiple; D006801:Humans; D008264:Macrophages / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D010879:Piperazines / Q000494:pharmacology*; D011758:Pyrroles / Q000494:pharmacology*; D020298:U937 Cells
D000900:Anti-Bacterial Agents; D010879:Piperazines; D011758:Pyrroles; C115651:BM 212