title: Tribulusamide A and B, new hepatoprotective lignanamides from the fruits of Tribulus terrestris: indications of cytoprotective activity in murine hepatocyte culture.
abstract: Tribulusamides A (1) and B (2), new lignanamides embracing two cinnamic amide parts joined in a cis configuration, were isolated from the fruits of Tribulus terrestris, together with four known compounds, N-trans-feruloyltyramine (3), terrestriamide (4), N-trans-coumaroyltyramine (5), and beta-sitosterol. The structures were elucidated by 2D-NMR spectroscopy. Addition of compounds 1-5, especially 1 and 2, to primary cultured mouse hepatocytes significantly prevented cell death induced by D-galactosamine (D-GalN)/tumor necrosis factor alpha (TNF-alpha).
authors.affiliation: Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, Japan.
authors.forename: J X
authors.initials: JX
authors.lastname: Li
authors.forename: Q
authors.initials: Q
authors.lastname: Shi
authors.forename: Q B
authors.initials: QB
authors.lastname: Xiong
authors.forename: J K
authors.initials: JK
authors.lastname: Prasain
authors.forename: Y
authors.initials: Y
authors.lastname: Tezuka
authors.forename: T
authors.initials: T
authors.lastname: Hareyama
authors.forename: Z T
authors.initials: ZT
authors.lastname: Wang
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
authors.forename: T
authors.initials: T
authors.lastname: Namba
authors.forename: S
authors.initials: S
authors.lastname: Kadota
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003373:Coumaric Acids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal; D008099:Liver / Q000166:cytology / Q000187:drug effects*; D008297:Male; D008516:Medicine, Chinese Traditional; D051379:Mice; D008813:Mice, Inbred ICR; D015394:Molecular Structure; D013057:Spectrum Analysis
chemical_list: D003373:Coumaric Acids; D004365:Drugs, Chinese Herbal; C115947:tribulusamide A; C115948:tribulusamide B