title: New perspectives offered by a French study of antibiotic resistance in day-care centers.
abstract: To provide ongoing information on regional trends of antibiotic resistance prevalence to pneumococci, a cross-sectional survey was conducted on a large representative sample of children attending day-care centers. Children were analyzed in spring (n = 379) and autumn (n = 379) for nasopharyngeal carriage. Streptococcus pneumoniae was detected in 149 children (39.4%) in spring and 204 (59.8%) in autumn. Half of these isolated strains showed penicillin insensitivity or resistance. A high proportion of children (43.6% in spring and 47.5% in autumn) had been treated with antibiotics during the 3 months prior to sample collection; 21.6% of isolated strains were serotype 6B, 20.1% type 23F, 18.9% type 19A and 19F, 11.5% type 14. Reduced susceptibility was frequently noted in serotype 23F, 14 and 9V, representing 93, 94 and 83% of identified serotypes, respectively. This type of survey on children in day-care centers can contribute to the understanding of regional variations in antibiotic resistance and provide information for epidemiological surveillance.
authors.affiliation: Department of Infectious Diseases, Archet Hospital, Nice, France.
authors.forename: P
authors.initials: P
authors.lastname: Dellamonica
authors.forename: C
authors.initials: C
authors.lastname: Pradier
authors.forename: B
authors.initials: B
authors.lastname: Dunais
authors.forename: H
authors.initials: H
authors.lastname: Carsenti
mesh_terms: D002648:Child; D002656:Child Day Care Centers; D003430:Cross-Sectional Studies; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D010403:Penicillin Resistance; D011008:Pneumococcal Infections / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D011159:Population Surveillance / Q000379:methods; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000302:isolation & purification