Can event-related potentials be evoked by extra-cochlear stimulation and used for selection purposes in cochlear implantation?
To investigate whether electrically evoked event-related responses (P300) could be elicited by extra-cochlear stimulation, measurements were performed on a group of adults fitted with the single-channel extra-cochlear implant. To optimize measurement conditions, and because of the low number of subjects still using an extra-cochlear device in our cochlear implant programme, measurements were also performed on a group of experienced users fitted with the intra-cochlear Nucleus multichannel device. For reference purposes, subjects with normal hearing (control group) were also included in the study. Reproducible late latency responses (N1 and P2 peaks) were found in the five extra-cochlear implant users, while P300s were present in four out of these five subjects. The latencies were longer than those of the control group, but were similar to those obtained in the intra-cochlear implant group. Significant correlations were found for most N1, P2 and P300 measurements evoked by the tonal stimuli and by speech stimuli. The P300 amplitudes, evoked by either tonal or speech stimuli, appeared to be related to speech perception ability. This led to the conclusion that N1, P2 and P300 measurements may have potential as a clinical tool for preoperative prediction and postoperative evaluation of sound processing on a cortical level.
Makhdoum
M J
MJ
Department of Otorhinolaryngology, University Hospital Nijmegen, The Netherlands.
Hinderink
J B
JB
Snik
A F
AF
Groenen
P
P
van den Broek
P
P
D000293:Adolescent; D000328:Adult; D002648:Child; D019929:Cochlear Implantation; D003638:Deafness / Q000503:physiopathology / Q000601:surgery*; D005071:Evoked Potentials; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013063:Speech Discrimination Tests; D013067:Speech Perception; D013997:Time Factors