Effect of nimodipine on infectious brain edema in rabbits.
OBJECTIVE
To study the effect of nimodipine (Nim) on infectious brain edema (BE).


METHODS
An infectious BE model was induced by injection of Bordetella pertussis suspension (BPS) into right internal carotid artery in rabbits. Eighteen rabbits were randomly divided into 3 groups (n = 6). Group BE: BPS (0.6 mL.kg-1) was given; group NS: normal saline was given as control; group Nim: 10 min after injection of BPS, Nim, 10 micrograms.kg-1, was injected i.v. as a bolus followed by continuous infusion of 0.75 microgram.kg-1.min-1. All the rabbits were kept under observation for 4 h. Evans blue staining was assessed; water, calcium, calmodulin (Cal), and sodium contents were determined in the right brain.


RESULTS
Nim vs BE: water 82.2 +/- 1.0% vs 84.4 +/- 1.2 (P < 0.01); calcium 10.5 +/- 1.3 mmol.kg-1 dry tissue vs 17.5 +/- 1.4 (P < 0.01); Cal 15.9 +/- 1.8 mumol.kg-1 wet tissue vs 24.0 +/- 3.0 (P < 0.01); sodium 173 +/- 7 mmol.kg-1 dry tissue vs 275 +/- 38 (P < 0.05). No significant difference for Evans blue staining between the two groups.


CONCLUSIONS
Nim had beneficial effect on the infectious BE.
Wen
F Q
FQ
Department of Pediatrics, Hu-nan Medical University, Changsha, China.
Zhang
B L
BL
Yu
P L
PL
Tao
Y G
YG
D000818:Animals; D001885:Bordetella Infections; D001886:Bordetella pertussis; D001921:Brain / Q000378:metabolism; D001929:Brain Edema / Q000188:drug therapy / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002147:Calmodulin / Q000378:metabolism; D009553:Nimodipine / Q000627:therapeutic use*; D011817:Rabbits; D011897:Random Allocation
D002121:Calcium Channel Blockers; D002147:Calmodulin; D009553:Nimodipine; D002118:Calcium