title: Prostate cancer in African-American men: outcome following radiation therapy with or without adjuvant androgen ablation.
abstract: OBJECTIVE
  To compare the outcome of irradiated clinically localized prostate cancer in African-American and white patients.
  
  
  METHODS
  This was a retrospective review of 1,201 men, 116 African-American and 1,085 white, with T1-T3, N0/NX, M0 prostate cancer receiving external radiation between 1987 and 1996. Pretreatment characteristics, treatment parameters, and outcome (relapse or rising prostate-specific antigen [PSA] levels, local recurrence, metastatic relapse, and survival) were compared between the groups using univariate and multivariate statistical methods.
  
  
  RESULTS
  There were no significant differences between African-American and white patients in T-stage, Gleason score, prostatic acid phosphatase (PAP) level, and testosterone level. African-Americans had a significantly lower incidence of abnormal digital rectal findings and a proportionally higher incidence of obstructive urinary symptoms at presentation and tended to be somewhat younger. A major difference between the two groups was in the significantly higher PSA levels among African-Americans (median, 14 ng/ml) than among white patients (median, 9.5 ng/ml). This translated into a higher incidence of unfavorable disease according to our criteria (39% vs. 25%) among African-Americans and, thus, to the more frequent use of adjuvant androgen ablation and to somewhat higher radiation doses in these patients. With a median follow-up of 42 months the overall 6-year freedom from relapse for African-Americans was 63% compared to 61% for whites (p = 0.634). We found no significant differences in biochemical relapse rates between any subgroups of African-Americans and whites. Specifically, even patients who did not have androgen ablation, when stratified by PSA levels, had similar outcomes regardless of race. Likewise, local recurrence and metastasis rates were not significantly different between the two groups.
  
  
  CONCLUSIONS
  Although African-American patients tend to have higher pretreatment PSA levels than white patients, the outcome for the disease is similar in the two groups when stratified by known pretreatment prognostic factors. Our data provide no evidence for the hypothesis that prostate cancer in African-Americans is intrinsically more virulent than in whites.
authors.affiliation: Department of Radiation Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston 77030, USA.
authors.forename: G K
authors.initials: GK
authors.lastname: Zagars
authors.forename: A
authors.initials: A
authors.lastname: Pollack
authors.forename: C A
authors.initials: CA
authors.lastname: Pettaway
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000208:ethnology / Q000473:pathology / Q000532:radiotherapy*; D001741:Black or African American / Q000706:statistics & numerical data*; D000368:Aged; D000369:Aged, 80 and over; D000726:Androgen Antagonists / Q000627:therapeutic use; D018572:Disease-Free Survival; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011446:Prospective Studies; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood / Q000208:ethnology / Q000473:pathology / Q000532:radiotherapy*; D044465:White People / Q000706:statistics & numerical data*
chemical_list: D000726:Androgen Antagonists; D017430:Prostate-Specific Antigen