Changes in the gastrointestinal tract, cardiovascular function and some drug metabolizing processes in rats and guinea-pigs intoxicated with aflatoxin B1.
The effects of aflatoxin B1 (AFB1) on the reactivity of the peripheral vessels, passage through the gastrointestinal system, production of hydrochloric acid and some liver functions were analyzed. The results shown the decreased glucuronidizing ability of the liver (58% of the initial value) accompanied by an increased amount of the unconjugated substrate while glycine conjugation was not changed in animals on the 3rd day after the treatment with AFB1. The uptake of 99mTc-SnO2 colloid was 1.14 times lower in the liver and 1.94 times higher in the spleen in AFB1 treated animals. A lowered activity of the glucuronizing system and a possibly indirectly lowered uptake of tin colloid in the liver indicate the toxic effect of AFB1 in hepatocytes. The other parameters studied were not changed or were changed only slightly.
Stĕtinová
V
V
Institute of Experimental Biopharmaceutics, Joint Laboratories of the Academy of Sciences of the Czech Republic, Hradec, Czech Republic.
Grossmann
V
V
Kvĕtina
J
J
D016604:Aflatoxin B1 / Q000633:toxicity*; D000818:Animals; D001711:Biotransformation; D004064:Digestive System / Q000187:drug effects*; D005744:Gastric Acid / Q000378:metabolism; D006168:Guinea Pigs; D006439:Hemodynamics / Q000187:drug effects*; D006636:Histamine Release / Q000187:drug effects; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D008111:Liver Function Tests; D008297:Male; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014655:Vascular Resistance / Q000187:drug effects
D004364:Pharmaceutical Preparations; D016604:Aflatoxin B1