Effect of some gastrointestinal hormones on antral, small intestinal and caecal myoelectrical activity in the conscious miniature pig.
The effect of i.v. infusion of gastrin (CCK-4), cholecystokinin (CCK-8) and pancreatic polypeptide (PP), 20 and 200 ng/kg/min for 1 h, on gastrointestinal electrical activity and arterial pressure was studied in conscious miniature pigs. During infusion of CCK-8 a transient hypertension was observed. In the antrum, the 3 peptides provoked an increase in slow wave activity and a decrease in spike activity. In the intestine, CCK-8 induced an increase in ileal spiking activity, whereas infusion of PP resulted in an increased frequency of long spike bursts in the caecum.
Wechsung
E
E
Laboratory of Veterinary Physiology, University Centre of Antwerp, Belgium.
Houvenaghel
A
A
D000818:Animals; D002432:Cecum / Q000294:innervation*; D003243:Consciousness; D004305:Dose-Response Relationship, Drug; D005768:Gastrointestinal Hormones / Q000008:administration & dosage / Q000494:pharmacology*; D007262:Infusions, Intravenous; D007421:Intestine, Small / Q000294:innervation*; D016065:Myoelectric Complex, Migrating / Q000187:drug effects* / Q000502:physiology; D010191:Pancreatic Polypeptide / Q000494:pharmacology; D011706:Pyloric Antrum / Q000294:innervation; D012844:Sincalide / Q000494:pharmacology; D013270:Stomach / Q000294:innervation*; D013552:Swine; D013556:Swine, Miniature; D013758:Tetragastrin / Q000494:pharmacology
D005768:Gastrointestinal Hormones; D013758:Tetragastrin; D010191:Pancreatic Polypeptide; D012844:Sincalide