title: Anti-inflammatory activity of acetophenones from Ophryosporus axilliflorus.
abstract: Seven acetophenone derivatives were isolated from the aerial parts of Ophryosporus axilliflorus (Griseb.) Hieron. These compounds were subjected to the carrageenan-induced mouse paw edema test where tremetone (7) showed extremely anti-inflammatory activity. Furthermore, the non-benzofuran acetophenones 5 and 6, showed a significant response.
authors.forename: L
authors.initials: L
authors.lastname: Favier
authors.forename: C
authors.initials: C
authors.lastname: Tonn
authors.forename: E
authors.initials: E
authors.lastname: Guerreiro
authors.forename: A
authors.initials: A
authors.lastname: Rotelli
authors.forename: L
authors.initials: L
authors.lastname: Pelzer
mesh_terms: D000098:Acetophenones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000098:Acetophenones; D000894:Anti-Inflammatory Agents, Non-Steroidal