mmr, a Mycobacterium tuberculosis gene conferring resistance to small cationic dyes and inhibitors.
The mmr gene, cloned from Mycobacterium tuberculosis, was shown to confer to Mycobacterium smegmatis resistance to tetraphenylphosphonium (TPP), erythromycin, ethidium bromide, acriflavine, safranin O, and pyronin Y. The gene appears to code for a protein containing four transmembrane domains. Studies of [3H]TPP intracellular accumulation strongly suggest that the resistance mediated by the Mmr protein involves active extrusion of TPP.
De Rossi
E
E
Department of Genetics and Microbiology, University of Pavia, 27100 Pavia, Italy.
Branzoni
M
M
Cantoni
R
R
Milano
A
A
Riccardi
G
G
Ciferri
O
O
D000595:Amino Acid Sequence; D003001:Cloning, Molecular; D004396:Coloring Agents; D004352:Drug Resistance, Microbial / Q000235:genetics; D005798:Genes, Bacterial; D007202:Indicators and Reagents; D008969:Molecular Sequence Data; D009169:Mycobacterium tuberculosis / Q000235:genetics*; D009861:Onium Compounds; D009943:Organophosphorus Compounds; D011815:R Factors; D017422:Sequence Analysis, DNA; D014316:Tritium
D004396:Coloring Agents; D007202:Indicators and Reagents; D009861:Onium Compounds; D009943:Organophosphorus Compounds; D014316:Tritium; C013289:tetraphenylphosphonium