Interleukin-1beta+3953 allele 2: association with disease status in adult periodontitis.
Adult periodontitis is a complex multifactorial disease whose etiology is not well defined. The pro-inflammatory and bone resorptive properties of interleukin-1 beta (IL-1beta) strongly suggest a role for this cytokine in the pathogenesis of periodontal disease. In the study reported here, the frequency of IL-1beta genotypes including allele 2 of the IL-1beta+3953 restriction fragment length bi-allelic polymorphism was significantly increased in patients with advanced adult periodontitis compared to those with early and moderate disease. Furthermore, allele 2 was associated with increased production of IL-1beta by activated peripheral blood polymorphonuclear cells of patients with advanced disease, although this increase failed to reach statistical significance. Finally, the data obtained revealed significant linkage disequilibrium between allele 2 of the IL-1beta+3953 polymorphism and allele 2 of the bi-allelic IL-1alpha-889 polymorphism in both patients and orally healthy controls. These findings provide new insight into the possible role of IL-1alpha and beta gene polymorphisms in the susceptibility to adult periodontitis.
Gore
E A
EA
Department of Microbiology and Immunology, Medical University of South Carolina, Charleston 29425-2230, USA.
Sanders
J J
JJ
Pandey
J P
JP
Palesch
Y
Y
Galbraith
G M
GM
D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis / Q000235:genetics*; D015810:Linkage Disequilibrium; D008297:Male; D018375:Neutrophil Activation; D009504:Neutrophils / Q000378:metabolism; D016017:Odds Ratio; D010518:Periodontitis / Q000235:genetics* / Q000276:immunology* / Q000378:metabolism; D012150:Polymorphism, Restriction Fragment Length; D018709:Statistics, Nonparametric
D007375:Interleukin-1