Control of neonatal tolerance to tissue antigens by peripheral T cell trafficking.
Self tolerance is acquired by the developing immune system. As reported here, particular properties of the neonatal tissue contribute to this process. Neonatal skin, but not adult skin, was accessible for naïve CD8 T cells. In mouse bone marrow chimeras generated at different ages, recent thymic emigrants were tolerized to a skin-expressed major histocompatibility complex class I antigen only during a neonatal period but not during adulthood. Blockade of T cell migration neonatally prevented tolerance induction. Thus, T cell trafficking through nonlymphoid tissues in the neonate is crucial for the establishment of self tolerance to sessile, skin-expressed antigens.
Alferink
J
J
Tumor Immunology Program, German Cancer Research Center, 69120 Heidelberg, Germany.
Tafuri
A
A
Vestweber
D
D
Hallmann
R
R
Hämmerling
G J
GJ
Arnold
B
B
D000818:Animals; D000831:Animals, Newborn; D017951:Antigen Presentation; D016026:Bone Marrow Transplantation; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002465:Cell Movement; D006084:Graft Rejection; D006183:H-2 Antigens / Q000276:immunology*; D015603:Keratinocytes / Q000276:immunology; D051379:Mice; D008822:Mice, Transgenic; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology; D017634:Self Tolerance / Q000276:immunology*; D012867:Skin / Q000276:immunology*; D016038:Skin Transplantation; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology; D018183:Transplantation Chimera
D006183:H-2 Antigens; C032876:H-2Kb protein, mouse