Excretion of triethyllead, diethyllead and inorganic lead in rabbits after injection of triethyl neopentoxy lead.
Triethyl neopentoxy lead (TEneoPOL: (C2H5)3Pb [OCH2C(CH3)3] liquid) was administered to rabbits in a single dose of 10 mg/kg body weight (5.4 mg Pb/kg body weight), and the urinary and fecal excretions of lead were measured to determine the fate of this triethyllead derivative. About 4% of the administered amount of was excreted into the urine during the 7 days after the injection; and about 68%, into the feces. In other words, the fecal excretion of total lead was about 17 times as great as the urinary excretion. About 85% of the urinary excretion of total lead was composed of diethyllead (Et2Pb2+), and about 92% of the fecal excretion consisted of inorganic lead (Pb2+). The major chemical species of lead excreted in the urine was Et2Pb2+, while the major species excreted in the feces was Pb2+. These results were similar to those of administration of tetraethyllead (Et4Pb) to rabbits. One of the 7 rabbits died on the day following the injection, and TEneoPOL, a triethyllead derivative, proved to be no less toxic than Et4Pb. However, this compound is immediately hydrolyzed by the ambient moisture to form a white solid compound, so that it is not accompanied by as great a risk of airway exposure as Et4Pb.
Arai
F
F
Department of Preventive Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.
Yamauchi
H
H
Chiba
K
K
Yoshida
K
K
D000818:Animals; D005243:Feces / Q000737:chemistry; D007275:Injections, Intravenous; D007700:Kinetics; D007854:Lead / Q000493:pharmacokinetics* / Q000652:urine; D009942:Organometallic Compounds / Q000493:pharmacokinetics* / Q000652:urine; D011817:Rabbits; D014556:Urine / Q000737:chemistry
D009942:Organometallic Compounds; C031330:diethyllead; D007854:Lead; C010360:triethyllead