Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase.
A number of developmental processes that involve cell migration, growth or morphogenesis depend on extracellular signals. A molecule that provides such signals, known as hepatocyte growth factor/scatter factor (HGF/SF), has attracted considerable interest in recent years because of its distinct structure, mechanism of activation and important roles throughout embryogenesis. This review discusses the main features of HGF/SF and its receptor, the product of the c-met protooncogene, and their role in embryogenesis.
Birchmeier
C
C
Dept of Medical Genetics, Max-Delbrück-Centrum for Molecular Medicine, Berlin, Germany. cbirch@mdc-berlin.de
Gherardi
E
E
D000818:Animals; D002465:Cell Movement; D000013:Congenital Abnormalities / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology; D005314:Embryonic and Fetal Development / Q000235:genetics / Q000502:physiology*; D004847:Epithelial Cells / Q000166:cytology / Q000187:drug effects; D019812:Heparan Sulfate Proteoglycans / Q000378:metabolism; D017228:Hepatocyte Growth Factor / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D008099:Liver / Q000196:embryology; D008648:Mesoderm / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D008958:Models, Molecular; D009024:Morphogenesis / Q000502:physiology; D009132:Muscles / Q000196:embryology; D009420:Nervous System / Q000196:embryology; D009474:Neurons / Q000502:physiology; D000072041:PAX3 Transcription Factor; D051761:Paired Box Transcription Factors; D011487:Protein Conformation; D019859:Proto-Oncogene Proteins c-met / Q000235:genetics / Q000502:physiology*; D011519:Proto-Oncogenes; D015398:Signal Transduction; D014157:Transcription Factors
D004268:DNA-Binding Proteins; D019812:Heparan Sulfate Proteoglycans; D000072041:PAX3 Transcription Factor; C489409:PAX3 protein, human; D051761:Paired Box Transcription Factors; D014157:Transcription Factors; C068686:Pax3 protein, mouse; D017228:Hepatocyte Growth Factor; D019859:Proto-Oncogene Proteins c-met