Identification of mammaglobin B, a novel member of the uteroglobin gene family.
In this report, we have identified, sequenced, and characterized the expression pattern of a novel human gene, mammaglobin B. Mammaglobin B (MGB2) is highly homologous to mammaglobin (MGB1), a previously characterized human gene whose expression is limited to the mammary epithelium and frequently up-regulated in human breast cancer cells. Based upon amino acid sequence similarities, both mammaglobin and mammaglobin B may be considered members of a larger, mammalian multigene family that includes rabbit uteroglobin, human Clara Cell 10-kDa protein (CC10), and the multimeric rat prostatein protein. Together with the human CC10 gene, mammaglobin and mammaglobin B are closely linked on human chromosome 11q13. However, despite their primary sequence similarity and close chromosomal proximity, the expression of mammaglobin and mammaglobin B is nonconcordant in both nonmalignant and neoplastic tissue.
Becker
R M
RM
Department of Ophthalmology/, Department of Pathology/, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, Missouri, 63110, USA.
Darrow
C
C
Zimonjic
D B
DB
Popescu
N C
NC
Watson
M A
MA
Fleming
T P
TP
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D001940:Breast / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D060785:Mammaglobin A; D060788:Mammaglobin B; D008969:Molecular Sequence Data; D009185:Myelin Proteins; D009363:Neoplasm Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D016133:Polymerase Chain Reaction; D011506:Proteins / Q000235:genetics; D011510:Proteolipids; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012469:Salivary Glands / Q000378:metabolism; D060765:Secretoglobins; D014594:Uterine Neoplasms / Q000378:metabolism; D014598:Uteroglobin / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D014599:Uterus / Q000378:metabolism
D060785:Mammaglobin A; D060788:Mammaglobin B; D009185:Myelin Proteins; D009363:Neoplasm Proteins; D011506:Proteins; D011510:Proteolipids; D012333:RNA, Messenger; C556389:SCGB1A1 protein, human; C556467:SCGB2A1 protein, human; C556448:SCGB2A2 protein, human; C556391:Scgb1a1 protein, rat; D060765:Secretoglobins; D014598:Uteroglobin