title: Use of novel urodynamic parameters, detrusor contraction duration and detrusor contraction index, in men with lower urinary tract symptoms.
abstract: The aim of this study was to correlate the results of the urodynamic measures, detrusor contraction duration (DCD) and detrusor contraction index (DCI), with voiding symptoms in untreated men with lower urinary tract symptoms (LUTS) and in men treated with doxazosin. Ninety-one men with untreated LUTS underwent urodynamic evaluation. DCD (duration of detrusor contraction in seconds), DCI (interval, in seconds, that urine is passed divided by the total duration of the bladder contraction), and standard urodynamic measures of obstruction were determined. The urodynamic findings were correlated with the severity of voiding symptoms as assessed by the International Prostate Symptom Score (I-PSS). Fifty of these men were treated subsequently with 4 mg of doxazosin for 3 months and then underwent repeat urodynamic evaluation, in which changes in symptom score and urodynamic results were analyzed. DCD was the only urodynamic measure that correlated significantly with the I-PSS results in untreated patients. Although DCD, detrusor pressure at maximum flow, and the Abrams-Griffiths number decreased in men treated with doxazosin, only DCI and symptom score improved significantly after treatment for 3 months. No urodynamic parameter was useful in predicting the likelihood of a favorable response to treatment with doxazosin. DCD and DCI may be useful urodynamic measures in untreated men with LUTS and in those treated with doxazosin. Further study of these parameters is warranted.
authors.affiliation: Department of Surgery, University of Chicago Pritzker School of Medicine, Illinois 60637, USA.
authors.forename: C D
authors.initials: CD
authors.lastname: Turner
authors.forename: D
authors.initials: D
authors.lastname: Kuznetsov
authors.forename: B A
authors.initials: BA
authors.lastname: Contreras
authors.forename: G S
authors.initials: GS
authors.lastname: Gerber
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use; D000368:Aged; D000369:Aged, 80 and over; D017292:Doxazosin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011470:Prostatic Hyperplasia / Q000188:drug therapy / Q000503:physiopathology; D016896:Treatment Outcome; D014546:Urinary Catheterization; D014555:Urination Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D014563:Urodynamics
chemical_list: D000317:Adrenergic alpha-Antagonists; D017292:Doxazosin