Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis.
This review covers recent advances of CD95 signaling. It focuses on CD95-interacting molecules, formation of the death inducing signaling complex and the role of caspases, particularly caspase-8, and their death substrates. We also discuss the relevance of mitochondria in the CD95-mediated apoptotic process and how viral proteins interfere with crucial steps of this signaling pathway.
Peter
M E
ME
Tumor Immunology Program, German Cancer Research Center, Im NeuenheimerFeld 280, D-69120, Heidelberg, Germany. m.peter@dkfz-heidelberg.de
Krammer
P H
PH
D000818:Animals; D017209:Apoptosis; D053181:Caspase 8; D053453:Caspase 9; D020169:Caspases / Q000502:physiology; D006801:Humans; D008928:Mitochondria / Q000502:physiology; D014764:Viral Proteins / Q000502:physiology; D019014:fas Receptor / Q000502:physiology*
D014764:Viral Proteins; D019014:fas Receptor; C505530:CASP8 protein, human; C506433:CASP9 protein, human; D053181:Caspase 8; D053453:Caspase 9; D020169:Caspases