The level of autoantibodies against oxidized LDL is not associated with the presence of coronary heart disease or diabetic kidney disease in patients with non-insulin-dependent diabetes mellitus.
Oxidation of low-density lipoprotein (LDL) may be an important factor in the development of diabetic macrovascular and renal complications. The level of autoantibodies against oxidized LDL (oxLDL-Ab) can be used as an index of LDL oxidation in vivo. The purpose of this study was to investigate the association between the level of oxLDL-Ab and the presence of coronary heart disease and renal dysfunction in patients with non-insulin-dependent diabetes mellitus (NIDDM). We determined the plasma levels of oxLDL-Ab in 46 NIDDM patients and 48 well matched nondiabetic control subjects. NIDDM patients had a moderately higher level of oxLDL-Ab than control subjects (0.083 +/- 0.051 vs. 0.062 +/- 0.045, p = 0.04). However, there was no difference in the level of oxLDL-Ab between subjects with and without coronary heart disease, and the level of oxLDL-Ab was not associated with indices of glomerular filtration rate or urinary albumin excretion.
Leinonen
J S
JS
Medical School, University of Tampere, and Department of Clinical Chemistry, Tampere University Hospital, Finland. bljale@uta.fi
Rantalaiho
V
V
Laippala
P
P
Wirta
O
O
Pasternack
A
A
Alho
H
H
Jaakkola
O
O
Ylä-Herttuala
S
S
Koivula
T
T
Lehtimäki
T
T
D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D003327:Coronary Disease / Q000276:immunology*; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology*; D003925:Diabetic Angiopathies / Q000276:immunology; D003928:Diabetic Nephropathies / Q000276:immunology*; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D001323:Autoantibodies; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein