title: Coronary hyperreactivity to adrenergic stimulation and increased nocturnal vagal tone trigger coronary vasospasm.
abstract: The relationship between autonomic nervous system activity (ANA) and coronary vasoreactivity during transient myocardial ischemia was determined in patients with vasospastic angina (VA). ANA was measured by power spectral analysis of heart rate variability and humoral factors following intravenous infusion of insulin in 24 patients with VA and 6 control patients. Nine (38%) of the VA patients had significant ST segment depression (STD), and 4 of these patients had symptomatic STD. The frequency of anginal episodes in the 9 patients with VA and STD was significantly greater than that in the 15 VA patients without STD (3.4 +/- 3.1 vs 0.5 +/- 0.8 episodes/week, p < 0.05). The increase in the LF/HF ratio 30 min after insulin injection in patients with STD was significantly greater than that in patients without STD (34 +/- 31% vs 4 +/- 34%, p < 0.05). All of the patients with VA and STD had significant coronary vasospasm in response to the infusion of < or = 20 micrograms of acetylcholine, higher levels of nocturnal parasympathetic activity, and greater norepinephrine production in response to insulin stimulation than the VA patients without STD. These findings suggest that increased vagal tone and hyperreactivity to adrenergic stimulation may trigger vasospasm in patients with VA.
authors.affiliation: First Department of Internal Medicine, Nippon Medical School, Tokyo, Japan. centerts@mail.246.ne.jp
authors.forename: T
authors.initials: T
authors.lastname: Saitoh
authors.forename: H
authors.initials: H
authors.lastname: Kishida
authors.forename: A
authors.initials: A
authors.lastname: Hanashi
authors.forename: Y
authors.initials: Y
authors.lastname: Tsukada
authors.forename: Y
authors.initials: Y
authors.lastname: Fukuma
authors.forename: J
authors.initials: J
authors.lastname: Sano
authors.forename: N
authors.initials: N
authors.lastname: Fukuma
authors.forename: Y
authors.initials: Y
authors.lastname: Kusama
authors.forename: H
authors.initials: H
authors.lastname: Hayakawa
mesh_terms: D000368:Aged; D000788:Angina Pectoris, Variant / Q000503:physiopathology*; D001341:Autonomic Nervous System / Q000503:physiopathology*; D003329:Coronary Vasospasm / Q000503:physiopathology*; D004594:Electrophysiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000503:physiopathology*