title: Chymase gene locus is not associated with myocardial infarction and is not linked to heart size or blood pressure.
abstract: The chymase gene is said to be important for the generation of angiotensin II in the heart and therefore is a candidate gene for heart disease. However, we were unable to find an association between allelic variants of the chymase gene and acute myocardial infarction or linkage between the chymase gene locus and heart size.
authors.affiliation: Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Virchow Klinikum, Humboldt University of Berlin, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Pfeufer
authors.forename: A
authors.initials: A
authors.lastname: Busjahn
authors.forename: A
authors.initials: A
authors.lastname: Vergopoulos
authors.forename: H
authors.initials: H
authors.lastname: Knoblauch
authors.forename: H
authors.initials: H
authors.lastname: Urata
authors.forename: K J
authors.initials: KJ
authors.lastname: Osterziel
authors.forename: M
authors.initials: M
authors.lastname: Menz
authors.forename: T F
authors.initials: TF
authors.lastname: Wienker
authors.forename: H D
authors.initials: HD
authors.lastname: Faulhaber
authors.forename: A
authors.initials: A
authors.lastname: Steinmetz
authors.forename: H
authors.initials: H
authors.lastname: Schuster
authors.forename: R
authors.initials: R
authors.lastname: Dietz
authors.forename: F C
authors.initials: FC
authors.lastname: Luft
mesh_terms: D000328:Adult; D001483:Base Sequence; D001794:Blood Pressure / Q000235:genetics*; D006332:Cardiomegaly / Q000235:genetics*; D053818:Chymases; D005260:Female; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D008969:Molecular Sequence Data; D009203:Myocardial Infarction / Q000235:genetics*; D011110:Polymorphism, Genetic; D012016:Reference Values; D012697:Serine Endopeptidases / Q000235:genetics*; D014427:Twins / Q000235:genetics*
chemical_list: D012697:Serine Endopeptidases; D053818:Chymases