title: Hypoglycaemic activity of an HMG-containing flavonoid glucoside, chamaemeloside, from Chamaemelum nobile.
abstract: The 3-hydroxy-3-methylglutaric acid (HMG) containing flavonoid glucoside chamaemeloside, has been determined to have in vivo hypoglycaemic activity comparable to that of free HMG. An improved isolation scheme for obtaining chamaemeloside from Chamaemelum nobile is presented.
authors.affiliation: Institute for Pharmaceutical Biology, Technical University of Braunschweig, Germany. g.koenig@tu-bs.de
authors.forename: G M
authors.initials: GM
authors.lastname: König
authors.forename: A D
authors.initials: AD
authors.lastname: Wright
authors.forename: W J
authors.initials: WJ
authors.lastname: Keller
authors.forename: R L
authors.initials: RL
authors.lastname: Judd
authors.forename: S
authors.initials: S
authors.lastname: Bates
authors.forename: C
authors.initials: C
authors.lastname: Day
mesh_terms: D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D001786:Blood Glucose / Q000032:analysis; D002460:Cell Line; D005951:Glucose Tolerance Test; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D001786:Blood Glucose; D005960:Glucosides; D007004:Hypoglycemic Agents; C115946:chamaemeloside