Percutaneous microcrystalline chitosan application for sealing arterial puncture sites.
Arterial catheterization is one of the most frequently performed inpatient diagnostic and therapeutic procedures in the development countries. Complications may occur after any catheterization from inadequate hemostasis, particularly in the setting of aggressive anticoagulation. This study suggests that microcrystalline chitosan (MCCh) sealant installation via an arterial sheath at the completion of catheterization may improve hemostasis. Results using MCCh in eight heparinized dogs documented significant reductions in manual compression time (P = 0.016) of the artery after withdrawal of both the sheath introducer and catheter. Comparative results were found in rats, wherein a created wound in the aorta could be sealed relatively quickly and easily. The biodegradability, optimalization, and a better pharmaceutical formulation of this potential hemostatic agent require further studies.
Hoekstra
A
A
Biomedical Technology Center, University of Groningen, The Netherlands. Prof. Dr. A. Hoekstra@cordis.nl
Struszczyk
H
H
Kivekäs
O
O
D000818:Animals; D001012:Aorta, Abdominal / Q000166:cytology; D001672:Biocompatible Materials / Q000737:chemistry / Q000627:therapeutic use*; D002404:Catheterization / Q000009:adverse effects; D002686:Chitin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000627:therapeutic use; D048271:Chitosan; D004285:Dogs; D006489:Hemostatic Techniques; D006490:Hemostatics / Q000737:chemistry / Q000627:therapeutic use*; D008297:Male; D011677:Punctures / Q000009:adverse effects; D051381:Rats; D017208:Rats, Wistar; D017539:Tunica Intima / Q000166:cytology; D014654:Vascular Patency
D001672:Biocompatible Materials; D006490:Hemostatics; D002686:Chitin; D048271:Chitosan