PASting together the mammalian clock.
Over the past year, the first components of the mammalian clock have been identified; Clock, bmal1 and three homologs of Drosophila period have been cloned, all of which encode PAS proteins. Expression of the mammalian period gene oscillates in many tissues in vivo and in immortalized cell cultures in vitro. Now, can we say that every cell has a circadian clock?
Whitmore
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Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS-INSERM-ULP, Illkirch, France.
Sassone-Corsi
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P
Foulkes
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NS
D056930:ARNTL Transcription Factors; D000818:Animals; D051784:Aryl Hydrocarbon Receptor Nuclear Translocator; D051792:Basic Helix-Loop-Helix Proteins; D001683:Biological Clocks / Q000502:physiology*; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D008322:Mammals; D009687:Nuclear Proteins / Q000737:chemistry / Q000502:physiology*; D056950:Period Circadian Proteins; D017434:Protein Structure, Tertiary; D018336:Receptors, Aryl Hydrocarbon; D013493:Suprachiasmatic Nucleus / Q000737:chemistry / Q000166:cytology* / Q000502:physiology; D014157:Transcription Factors / Q000737:chemistry / Q000502:physiology*
D056930:ARNTL Transcription Factors; D051784:Aryl Hydrocarbon Receptor Nuclear Translocator; D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D009687:Nuclear Proteins; D056950:Period Circadian Proteins; D018336:Receptors, Aryl Hydrocarbon; D014157:Transcription Factors; C539040:PER protein, Drosophila