Psychotic symptoms in dementia associated with motor neuron disease: a pathophysiological hypothesis.
Three patients with neuropathologically confirmed frontotemporal dementia, motor neuron disease type, manifested hallucinations. In this dementia, the superficial layers of the frontal and temporal cortices are predominantly affected. Hallucinations may emerge as release phenomena secondary to selective laminar cortical involvement.
Nitrini
R
R
Department of Neurology, Faculty of Medicine, University of São Paulo, Brazil. rnitrini@usp.br
Rosemberg
S
S
D000328:Adult; D003704:Dementia / Q000150:complications / Q000503:physiopathology* / Q000523:psychology*; D004576:Electromyography; D017809:Fatal Outcome; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D006212:Hallucinations / Q000523:psychology; D006801:Humans; D008297:Male; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000150:complications / Q000503:physiopathology* / Q000523:psychology*; D013702:Temporal Lobe / Q000503:physiopathology