title: [Improvement in the treatment of acute myocardial infarct by the establishment of a thrombolysis unit in a cardiology servic].
abstract: OBJECTIVE
  Lack of available beds in the coronary care unit, makes time to thrombolysis still too long. Although fibrinolytic therapy is administered in the emergency department in most hospitals, mean in-hospital delay continues to be long. Our purpose was to improve the treatment of these patients and to evaluate if this delay could be shortened by creating a thrombolysis unit for the treatment of patients with acute myocardial infarction.
  
  
  METHODS
  A thrombolysis unit in the cardiology department was set up to treat patients with acute myocardial infarction who couldn't be admitted directly in the coronary care unit because of lack of available beds. Time to treatment in both groups of patients were compared.
  
  
  RESULTS
  Two hundred twenty-five patients with acute myocardial infarction and ST-segment elevation were included: 86 (38%) of them were admitted to the thrombolysis unit and the other 139 (62%) to the coronary care unit. There were no differences in baseline characteristics or in the pre-hospital delay between both groups. Time from hospital admission to thrombolysis was 59 minutes in patients treated in the thrombolysis unit versus 70 minutes in those treated in the coronary care unit (p < 0.001), and time from the admission to both units to fibrinolytic therapy was of 20 minutes versus 30 minutes respectively (p < 0.0001). There were no differences between both groups in the incidence of complications.
  
  
  CONCLUSIONS
  In-hospital delay in thrombolysis remains too long. Implementation of a thrombolysis unit in the cardiology department shortens this delay and offers the possibility to treat patients with acute myocardial infarction at least as well as in the coronary care unit, without dependence on the availability of free beds in this unit.
authors.affiliation: Departamento de Medicina, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Facultad de Medicina, Universidad de Barcelona.
authors.forename: M
authors.initials: M
authors.lastname: Sitges
authors.forename: X
authors.initials: X
authors.lastname: Bosch
authors.forename: G
authors.initials: G
authors.lastname: Sanz
authors.forename: M
authors.initials: M
authors.lastname: Heras
authors.forename: F
authors.initials: F
authors.lastname: Miranda
authors.forename: I
authors.initials: I
authors.lastname: Anguera
authors.forename: A
authors.initials: A
authors.lastname: Sambola
authors.forename: A
authors.initials: A
authors.lastname: Betriu
mesh_terms: D003325:Coronary Care Units / Q000458:organization & administration*; D004630:Emergencies; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy*; D015912:Thrombolytic Therapy; D013997:Time Factors
chemical_list: D005343:Fibrinolytic Agents