Significance of cell proliferation measurement in gastric cancer.
Cell kinetic data may be important indicators of clinical behaviour in many types of cancer. Recently, several antibodies to cell-cycle associated antigens have been characterised. This overview summarises the advantages and disadvantages of different methods for the assessment of cell proliferation. Moreover, the prognostic value of proliferative activity in gastric cancer is discussed and suggestions for future research are given.
Schipper
D L
DL
Department of Gastroenterology, University Hospital Nijmegen, The Netherlands.
Wagenmans
M J
MJ
Peters
W H
WH
Wagener
D J
DJ
D034961:Antigens, Nuclear; D002455:Cell Division; D005434:Flow Cytometry; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D008940:Mitotic Index; D009687:Nuclear Proteins / Q000378:metabolism; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D013274:Stomach Neoplasms / Q000473:pathology*; D013936:Thymidine / Q000378:metabolism
D034961:Antigens, Nuclear; D019394:Ki-67 Antigen; D009687:Nuclear Proteins; D018809:Proliferating Cell Nuclear Antigen; D013936:Thymidine