Selective augmentation of antibodies in various mucosal regions, after intranasal immunization with diphtheria in mice.
The kinetics of antibody responses were analyzed in various mucosal membranes as well as in the blood and the spleen after intranasal vaccination of mice with diphtheria toxoid. The results show a selective increase in antibody response in the respiratory area and the vagina followed by the gastrointestinal tract, but not in the spleen. IgG and IgM showed an increase 7 days after revaccination, followed by a rapid decline. However, IgA peaked 3 days after revaccination and did not decline throughout the study.
Gizurarson
S
S
Department of Pharmacy, University of Iceland, P.O. Box 7171, 127 Reykjavik, Iceland.
Sigurdoardóttir
M
M
Stanzeit
B
B
D000281:Administration, Intranasal; D000818:Animals; D004064:Digestive System / Q000276:immunology*; D004168:Diphtheria Toxoid / Q000008:administration & dosage* / Q000276:immunology; D005260:Female; D007114:Immunization; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis*; D051379:Mice; D008807:Mice, Inbred BALB C; D009092:Mucous Membrane / Q000276:immunology; D012137:Respiratory System / Q000276:immunology*; D013154:Spleen / Q000276:immunology*
D004168:Diphtheria Toxoid; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins