Image cytometry in early graft-versus-host disease.
Image cytometry was used to measure the size, shape, and texture of lymphocyte nuclei in 24 skin biopsy specimens retrospectively selected from patients with early, nonspecific, graft-versus-host disease (GVHD)-like eruptions. Half of these patients had progressed to overt GVHD, whereas half had never developed more than a mild nonspecific eruption. Significant differences were detected in the nuclear texture of the eruptions of the two groups, but the differences were not consistent enough to suggest that image cytometry might play a significant role in recognition of early GVHD.
Fleming
M G
MG
Department of Dermatology, Medical College of Wisconsin, Milwaukee 53226-3548, USA.
Khona
D
D
Kohler
S
S
D002467:Cell Nucleus / Q000473:pathology; D006086:Graft vs Host Disease / Q000473:pathology*; D006801:Humans; D019044:Image Cytometry; D008214:Lymphocytes / Q000473:pathology; D015999:Multivariate Analysis; D012867:Skin / Q000166:cytology / Q000473:pathology