CD4 dimerization and oligomerization: implications for T-cell function and structure-based drug design.
Recent studies of CD4 structure and function have revealed possible mechanisms for CD4 self-association, with implications for its role in T-cell activation. Here, the authors discuss the formulation of a hypothetical three-dimensional model of CD4 oligomerization and how it impacts on the understanding of T-cell function and rational drug design targeting specific CD4 surface functional sites.
Li
S
S
Kimmel Cancer Institute, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Satoh
T
T
Korngold
R
R
Huang
Z
Z
D015704:CD4 Antigens / Q000737:chemistry* / Q000276:immunology; D019281:Dimerization; D015195:Drug Design; D006801:Humans; D008213:Lymphocyte Activation; D008285:Major Histocompatibility Complex / Q000276:immunology; D008956:Models, Chemical; D018448:Models, Immunological; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology*
D015704:CD4 Antigens; D011948:Receptors, Antigen, T-Cell