title: Epithelioid haemangioendothelioma of the lung in a dog.
abstract: Epithelioid haemangioendothelioma of the lung was found in a 9-year-old female dog. The tumour occurred bilaterally in the form of multiple, discrete, small nodular lesions with a similar histological appearance. The lesions were characterized by a hypocellular sclerotic core surrounded by a more cellular peripheral zone, from which the tumour tissue extended into the adjacent alveolar spaces and bronchioles in a micropolypoid manner, filling their lumina. In addition, invasion of the pulmonary vessels was frequently observed within, around, and at a distance from the nodular neoplastic lesions. Most of the tumour cells had abundant eosinophilic cytoplasm, large, round or oval nuclei, and occasional intracytoplasmic vacuoles containing red blood cells. By means of immunolabelling, factor VIII-related antigen, a marker for endothelial cells, was detected within the cytoplasm of a small proportion (< 5%) of the tumour cells. This appears to be the first report of such a tumour in an animal other than man.
authors.affiliation: Department of Veterinary Pathology, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Machida
authors.forename: T
authors.initials: T
authors.lastname: Arimura
authors.forename: Y
authors.initials: Y
authors.lastname: Otagiri
authors.forename: K
authors.initials: K
authors.lastname: Kiryu
authors.forename: T
authors.initials: T
authors.lastname: Oka
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D018323:Hemangioendothelioma, Epithelioid / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*; D007124:Immunoenzyme Techniques / Q000662:veterinary; D008175:Lung Neoplasms / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D014841:von Willebrand Factor