title: Isolation of mhc class II DMA and DMB cDNA sequences in a marsupial: the gray short-tailed opossum (Monodelphis domestica).
abstract: We report the cDNA sequences for the DMA and DMB family of Mhc genes of the gray short-tailed opossum. Until now DM sequences were available only in eutherian mammals. The marsupial sequences indicate that both members of the family are old and probably diverged from other classical class II families about the time of the radiation of jawed vertebrates some 450 million years ago. We examine the evolutionary rates of equivalent sets of classical and nonclassical genes to check for rate heterogeneity. We find the alpha-1 domain of the DR genes to be untypically conservative in its evolutionary mode. The DM genes appear to evolve at rates typical of other class II genes, indicating that their placement at the root of class II gene evolutionary trees may be justified.
authors.affiliation: Max-Planck-Institut für Biologie, Abteilung Immungenetik, Corrensstrasse 42, Tübingen, D-72076 Germany. colm.o'huigin@tuebingen.mpg.de
authors.forename: C
authors.initials: C
authors.lastname: O'hUigin
authors.forename: H
authors.initials: H
authors.lastname: Sültmann
authors.forename: H
authors.initials: H
authors.lastname: Tichy
authors.forename: B W
authors.initials: BW
authors.lastname: Murray
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D018076:DNA, Complementary; D005802:Genes, MHC Class II; D006801:Humans; D008969:Molecular Sequence Data; D009893:Opossums / Q000235:genetics*; D010802:Phylogeny; D017386:Sequence Homology, Amino Acid
chemical_list: D018076:DNA, Complementary