[Clinical case of the month. Hepatoportal sclerosis in a patient treated with azathioprine].
We report a case of hepatoportal sclerosis in a renal transplant patient treated with azathioprine. The initial symptom was ascites. On the biochemical level, there were cholestasis without cytolysis or hepatocellular insufficiency. A presinusoidal portal hypertension was found on haemodynamic studies, without portal thrombosis at CT-scan. A diagnosis of hepatoportal sclerosis was evoked on histology and attributed to azathioprine. This case gives an illustration of a classical albeit rare complication of azathioprine. The indolent pattern of the disease and the risk of variceal bleeding point out the need for a hepatic follow-up during the treatment.
Roland
S
S
Service de Gastro-entérologie, Université de Liège.
Delwaide
J
J
Cornet
G
G
Mahieu
P
P
Jacquet
N
N
Belaiche
J
J
D000328:Adult; D001201:Ascites / Q000139:chemically induced; D001379:Azathioprine / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology*; D002779:Cholestasis / Q000139:chemically induced; D003937:Diagnosis, Differential; D006801:Humans; D006975:Hypertension, Portal / Q000139:chemically induced* / Q000175:diagnosis; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D008103:Liver Cirrhosis / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male
D007166:Immunosuppressive Agents; D001379:Azathioprine