[Increase in the level of augmenter of liver regeneration mRNA in the rat regenerating liver after partial hepatectomy].
Augmenter of liver regeneration (ALR) is a novel hepatic stimulator. After 70% of the rat liver was removed, ALR-like activity in the remnant liver began to increase within 24 h. In parallel with the activity, the ALR mRNA level in the remnant liver increased 12 h after the operation and reached a maximum in 24 h. These findings indicate that the liver itself produces ALR, which may be a hepatotropic factor acting as a trigger for liver regeneration.
Yang
X M
XM
Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing.
Xie
L
L
Wu
Z Z
ZZ
Wu
C T
CT
He
F C
FC
D000818:Animals; D006133:Growth Substances / Q000378:metabolism*; D006498:Hepatectomy / Q000379:methods; D036341:Intercellular Signaling Peptides and Proteins; D008099:Liver / Q000378:metabolism*; D008115:Liver Regeneration; D008297:Male; D010455:Peptides / Q000378:metabolism*; D011184:Postoperative Period; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; D012333:RNA, Messenger; C073456:hepatic stimulator substance