[Studies of malignant transformation of human fetal lung cells induced by organic extract from tap water].
Expression of P53 protein was determined in the process and the end of induction of malignant transformation in human fetal lung cells, with organic extract from tap water in a river of City G, to study its molecular mechanism. Results showed that the water sample of experimental doses could induce formation of cell malignant transformation foci to different extent and had certain toxicity to cells. High expression of P53 protein was observed in cell nuclei 15 days after exposure and before formation of cell transformation foci, or 30 days after exposure and formation of them. It suggests that changes of P53 protein may relate to cell malignant transformation to certain extent, and play some roles in the process of it.
Zhang
J
J
Department of Environment Health, Shanghai Medical University.
Zhu
H
H
D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002478:Cells, Cultured; D005333:Fetus; D006801:Humans; D008168:Lung / Q000166:cytology* / Q000378:metabolism; D009152:Mutagenicity Tests; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D014881:Water Supply
D016159:Tumor Suppressor Protein p53; D014874:Water Pollutants, Chemical