Some neoplasms and some hamartomatous syndromes: genetic considerations.
This is the first of three articles on modern genetic concepts of a number of syndromes and disorders. About 1% of cancer mutations arise in the germline and produce a variety of neoplasms and hamartomatous syndromes. However, upward of 10-15% of all cancers have a major inherited component, although many of these are still enigmatic. The genetic basis is presented and following a review of many neoplasms and hamartomatous syndromes, the RET proto-oncogene is discussed as an example.
Cohen
M M
MM
Department of Oral & Maxillofacial Sciences, Faculty of Dentistry, Dalhousie University, Halifax, Nova Scotia, Canada.
D004252:DNA Mutational Analysis; D029721:Drosophila Proteins; D016147:Genes, Tumor Suppressor; D006223:Hamartoma Syndrome, Multiple / Q000235:genetics*; D006801:Humans; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics*; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000235:genetics; D051096:Proto-Oncogene Proteins c-ret; D011519:Proto-Oncogenes; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics
D029721:Drosophila Proteins; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases; C416649:Ret protein, Drosophila