title: Failure inference from a marker process based on a bivariate Wiener model.
abstract: Many models have been proposed that relate failure times and stochastic time-varying covariates. In some of these models, failure occurs when a particular observable marker crosses a threshold level. We are interested in the more difficult, and often more realistic, situation where failure is not related deterministically to an observable marker. In this case, joint models for marker evolution and failure tend to lead to complicated calculations for characteristics such as the marginal distribution of failure time or the joint distribution of failure time and marker value at failure. This paper presents a model based on a bivariate Wiener process in which one component represents the marker and the second, which is latent (unobservable), determines the failure time. In particular, failure occurs when the latent component crosses a threshold level. The model yields reasonably simple expressions for the characteristics mentioned above and is easy to fit to commonly occurring data that involve the marker value at the censoring time for surviving cases and the marker value and failure time for failing cases. Parametric and predictive inference are discussed, as well as model checking. An extension of the model permits the construction of a composite marker from several candidate markers that may be available. The methodology is demonstrated by a simulated example and a case application.
authors.affiliation: McGill University, Montreal, Canada.
authors.forename: G A
authors.initials: GA
authors.lastname: Whitmore
authors.forename: M J
authors.initials: MJ
authors.lastname: Crowder
authors.forename: J F
authors.initials: JF
authors.lastname: Lawless
mesh_terms: D001699:Biometry; D006801:Humans; D015993:Life Tables; D015233:Models, Statistical; D013269:Stochastic Processes