title: [Persistent value of intra-arterial fibrinolysis 8 hours or more following central retinal artery occlusion or of its branches].
abstract: OBJECTIVE
  To establish that intra-arterial fibrinolysis of the ophthalmic artery can still be efficient 8 hours or more after a central retinal artery occlusion.
  
  
  METHODS
  Nine to twenty hours (average 12.5 H) after a loss of vision due to a central retinal artery occlusion or the occlusion of its branches, 7 patients were treated by intra-arterial fibrinolysis. The vision of the affected eye was limited to light perception for four patients, to hand movement at 1 meter for two patients, and to 4/10 P2 for one patient. Under radiological guidance, 300.000 IU of urokinase was injected through a microcatheter placed in the ophthalmic artery (6 patients), or in the facial artery (1 patient); in this case the angiogram showed an occlusion of the internal carotid artery and a retrograde filling of the ophthalmic artery through the facial artery.
  
  
  RESULTS
  We did not observed any complication. The 3 patients who had a vision better than light perception recovered a vision of 10/10 P2. For the others: two patients recovered a vision of 9/10 P2 and 5/10 P2, two did not recover.
  
  
  CONCLUSIONS
  Fibrinolysis of the ophthalmic artery must ideally be performed as soon as possible, but a recovery is still possible more than 8 hours after the onset of the loss of vision. The time limit is not yet defined but after 24 hours, the chance of improvement seems to be very low.
authors.affiliation: Service de Neuroradiologie Interventionnelle, Fondation Ophtalmologique A. de Rothschild, Paris.
authors.forename: A
authors.initials: A
authors.lastname: Weill
authors.forename: C
authors.initials: C
authors.lastname: Cognard
authors.forename: M
authors.initials: M
authors.lastname: Piotin
authors.forename: L
authors.initials: L
authors.lastname: Laloum
authors.forename: L
authors.initials: L
authors.lastname: Castaings
authors.forename: J
authors.initials: J
authors.lastname: Moret
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007269:Injections, Intra-Arterial; D008297:Male; D008875:Middle Aged; D009880:Ophthalmic Artery; D015356:Retinal Artery Occlusion / Q000188:drug therapy*; D015912:Thrombolytic Therapy; D013997:Time Factors; D016896:Treatment Outcome; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage*; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D014568:Urokinase-Type Plasminogen Activator