Apparent reactivation of a red cell alloantibody in a healthy individual after G-CSF administration.
Granulocyte-colony stimulating factor (G-CSF) has been successfully administered to healthy subjects to mobilize peripheral blood stem cells (PBSC) for allogeneic transplantation. Adverse events are moderate. We report the first case of apparent reactivation of an alloantibody to a blood cell antigen (Jk(a)) after G-CSF administration to a healthy subject and its transmission to the PBSC transplant recipient; no concomitant reactivation of other alloantibodies was detected. This case raises questions on the effect of G-CSF on the immune system and its safety in healthy individuals.
Norol
F
F
ETS Sud-Est Francilien, Hôpital Henri Mondor, Creteil, France.
Bonin
P
P
Charpentier
F
F
Bierling
P
P
Beaujean
F
F
Cartron
J P
JP
Bories
D
D
Kuentz
M
M
D000276:Adjuvants, Immunologic / Q000009:adverse effects*; D000328:Adult; D000917:Antibody Formation / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D007518:Isoantibodies / Q000276:immunology*; D000078224:Lenograstim; D011994:Recombinant Proteins / Q000009:adverse effects; D019172:Transplantation Conditioning / Q000009:adverse effects
D000276:Adjuvants, Immunologic; D007518:Isoantibodies; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D000078224:Lenograstim