Chronic neurobehavioral and central and autonomic nervous system effects of Tokyo subway sarin poisoning.
To evaluate delayed (prolonged) neurobehavioral and neurophysiological effects of acute sarin poisoning, nine male and nine female patients of the Tokyo subway sarin poisoning in Japan were examined by neurobehavioral tests, posttraumatic stress disorder (PTSD) checklist, brain evoked potentials, computerized static posturography, and electrocardiographic R-R interval variability, 6-8 months after the poisoning. Their serum cholinesterase activities on the day of the poisoning (March 20, 1995) were 13-131 (mean 72.1) IU/L. The results suggested delayed effects on psychomotor performance, the higher and visual nervous system and the vestibulo-cerebellar system with psychiatric symptoms resulting from PTSD.
Yokoyama
K
K
Department of Public Health and Occupational Medicine, Graduate School of Medicine, University of Tokyo, Japan.
Araki
S
S
Murata
K
K
Nishikitani
M
M
Okumura
T
T
Ishimatsu
S
S
Takasu
N
N
D001342:Autonomic Nervous System Diseases / Q000139:chemically induced* / Q000453:epidemiology; D002493:Central Nervous System Diseases / Q000139:chemically induced* / Q000453:epidemiology; D002619:Chemical Warfare Agents / Q000506:poisoning*; D004562:Electrocardiography / Q000187:drug effects; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D009483:Neuropsychological Tests; D011187:Posture; D011597:Psychomotor Performance / Q000187:drug effects; D011890:Railroads; D012524:Sarin / Q000506:poisoning*; D013313:Stress Disorders, Post-Traumatic / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D014041:Tokyo / Q000453:epidemiology
D002619:Chemical Warfare Agents; D012524:Sarin