Different effects of atrial and C-type natriuretic peptide on the urinary excretion of endothelin-1 in man.
1. Following the observation that brain natriuretic peptide enhances the urinary excretion rate of endothelin-1, the relationship between natriuretic peptides and urinary endothelin-1 was further investigated. Six healthy volunteers received, on three different occasions, increasing doses of atrial or C-type natriuretic peptide (0, 2 and 4 pmol.min-1.kg-1 for 1 h each), or placebo.2. Atrial natriuretic peptide caused significant increases in the urinary excretion of cGMP, sodium and endothelin-1, without affecting plasma endothelin-1, renal plasma flow, glomerular filtration rate and urine flow rate. C-type natriuretic peptide did not modify any of these parameters. During atrial natriuretic peptide infusion, urinary endothelin-1 directly correlated with plasma atrial natriuretic peptide, urinary cGMP and sodium excretion.3. These results indicate that enhancement of the urinary excretion of endothelin-1 by natriuretic peptides is dose-dependent and somewhat related to their ability to bind to natriuretic peptide receptors A, activate guanylate cyclase and induce a natriuretic response.
La Villa
G
G
Istituto di Medicina Interna, University of Florence School of Medicine, viale Morgagni 85, I-50134 Florence, Italy.
Mannelli
M
M
Lazzeri
C
C
Vecchiarino
S
S
de Feo
M L
ML
Tosti Guerra
C
C
Bandinelli
R
R
Foschi
M
M
Franchi
F
F
D000328:Adult; D000704:Analysis of Variance; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D018592:Cross-Over Studies; D006152:Cyclic GMP / Q000652:urine; D004305:Dose-Response Relationship, Drug; D019332:Endothelin-1 / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D009318:Natriuresis; D020097:Natriuretic Peptide, Brain / Q000494:pharmacology*; D016037:Single-Blind Method
D019332:Endothelin-1; D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor; D006152:Cyclic GMP