Molecular epidemiology of epithelial tumors.
Within the past year there has been a dramatic increase in the number of molecular epidemiologic studies reported in the literature, particularly those evaluating gene-gene and gene-environment interactions. Molecular epidemiologic studies have become more sophisticated owing to collaborations between laboratory scientists and epidemiologists, and because these studies are now conducted on well-characterized populations with appropriate study design. Although there continue to be inconsistencies across some studies, it is clear that the evaluation of gene-gene and gene-environment interactions can delineate portions of the population who are particularly sensitive to certain carcinogenic exposures, based on polymorphisms in genes involved in preventing and controlling carcinogenesis. Identification of these subsets of susceptible individuals can result in the design of preventive strategies targeting the most "at risk" populations.
Ambrosone
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Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, AR 72079, USA.
Thompson
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P
D002273:Carcinogens / Q000009:adverse effects; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics; D004032:Diet; D016147:Genes, Tumor Suppressor / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D006801:Humans; D017720:Molecular Epidemiology; D009375:Neoplasms, Glandular and Epithelial / Q000453:epidemiology / Q000235:genetics* / Q000517:prevention & control*; D009857:Oncogenes / Q000235:genetics; D011110:Polymorphism, Genetic; D012907:Smoking / Q000009:adverse effects
D002273:Carcinogens; D012739:Gonadal Steroid Hormones; D019363:Cytochrome P-450 CYP1A1; D005982:Glutathione Transferase