Correlation between the growth of uterine leiomyomata and estrogen and progesterone receptor content in needle biopsy specimens.
OBJECTIVE
To examine the relationship between estrogen receptor (ER) and progesterone receptor (PR) content in needle biopsy specimens and the growth of uterine leiomyomata after biopsy.


METHODS
Prospective clinical study.


METHODS
University teaching hospital.


METHODS
Thirty-one women with uterine leiomyomata and a normal menstrual cycle.


METHODS
Transcervical needle biopsy of uterine leiomyomata.


METHODS
The relationships between histologic features (smooth muscle content, immunohistochemical expression of ER and PR) and the percent increase over a 12-month observation period in the volume of the largest myoma nodule measured by magnetic resonance imaging were analyzed.


RESULTS
Both the density and intensity of immunohistochemical staining of PRs in uterine leiomyoma tissue showed significant positive correlation with leiomyoma growth.


CONCLUSIONS
The growth of uterine leiomyomata can be determined by histologic and immunohistochemical analysis of needle biopsy specimens from uterine leiomyomata.
Ichimura
T
T
Department of Obstetrics and Gynecology, Osaka City University Medical School, Osaka, Japan.
Kawamura
N
N
Ito
F
F
Shibata
S
S
Minakuchi
K
K
Tsujimura
A
A
Umesaki
N
N
Ogita
S
S
D000328:Adult; D001707:Biopsy, Needle; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D011446:Prospective Studies; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*; D014594:Uterine Neoplasms / Q000378:metabolism / Q000473:pathology*
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone