title: Effect of thyroid hormones on Lp(a) and lipid metabolism.
abstract: The effect of thyroid hormones on lipoprotein(a) plasma concentrations and the other parameters of lipoprotein metabolism was studied in 158 patients with thyroid dysfunction and in 37 euthyroid controls (cross-sectional study). Multiple regression analysis revealed that 65.5% of the variability in lipoprotein(a) levels were predicted by changes in lipoprotein(a) phenotypes (60.5%), thyrotropin (3.5%), and age (0.8%). The lipid parameters, however, showed no significant effect on lipoprotein(a). A subgroup analysis on samples from patients with large lipoprotein(a) isoforms showed that 28% of the variability in lipoprotein(a) concentrations could be explained by changes in thyroid function (19.1%), age (6.5%) and triglycerides (3.5%). Much stronger correlations were found between thyrotropin and total cholesterol, low density lipoprotein cholesterol or apolipoprotein B respectively (R2=0.951 for low density lipoprotein cholesterol, R2=0.801 for apolipoprotein B). Our data suggest that thyroid hormone is a significant modulator of lipoprotein(a) metabolism. However, different mechanisms are responsible for the change in lipoprotein(a) levels and for the decrease in total- and low density lipoprotein cholesterol levels.
authors.affiliation: Institute of Clinical Chemistry and Hematology, Kantonsspital, St. Gallen, Switzerland.
authors.forename: H
authors.initials: H
authors.lastname: Engler
authors.forename: W F
authors.initials: WF
authors.lastname: Riesen
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D017270:Lipoprotein(a) / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D013961:Thyroid Gland / Q000502:physiology; D013963:Thyroid Hormones / Q000502:physiology*
chemical_list: D017270:Lipoprotein(a); D013963:Thyroid Hormones