title: Decreased seizure threshold and more rapid rate of kindling in rats with cortical malformation induced by prenatal treatment with methylazoxymethanol.
abstract: In humans, cortical malformations are highly epileptogenic. In rats, prenatal treatment with methylazoxymethanol (MAM) cause a diffuse cortical malformation that is yet not associated with seizures. We performed rapid hippocampal kindling in MAM and control rats. We show that MAM rats present (i) a lower initial afterdischarge threshold; (ii) a more rapid progression to generalized seizures. We conclude that MAM rats may serve as models for human epileptogenic cortical malformations.
authors.affiliation: INSERM U29, 123 Bd Port Royal, 75 674, Paris cedex 14, France. chevassus@cochin.inserm.fr
authors.forename: N
authors.initials: N
authors.lastname: Chevassus-au-Louis
authors.forename: Y
authors.initials: Y
authors.lastname: Ben-Ari
authors.forename: M
authors.initials: M
authors.lastname: Vergnes
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D002540:Cerebral Cortex / Q000002:abnormalities / Q000187:drug effects*; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D006624:Hippocampus / Q000187:drug effects; D007696:Kindling, Neurologic; D008746:Methylazoxymethanol Acetate / Q000031:analogs & derivatives* / Q000633:toxicity; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011930:Reaction Time / Q000187:drug effects*; D012640:Seizures / Q000139:chemically induced*
chemical_list: D008746:Methylazoxymethanol Acetate; C030667:methylazoxymethanol