Risk of recurrent spontaneous abortion, cigarette smoking, and genetic polymorphisms in NAT2 and GSTM1.
Maternal smoking increases the risk of spontaneous abortion. Polymorphic N-acetyltransferase (NAT2) and glutathione S-transferase (GSTM1) affect metabolism of some mutagens found in tobacco smoke. Genotypes and smoking were studied in women with at least two spontaneous abortions (N = 32) and those with at least two livebirths (N = 179). Smoking slightly increased risk (odds ratio = 1.3; 95% confidence interval = 0.6-2.9), but NAT2 and GSTM1 did not. NAT2 or GSTM1 polymorphisms did not appreciably modify smoking-related risk.
Mendola
P
P
Department of Social and Preventive Medicine, University at Buffalo, NY, USA.
Moysich
K B
KB
Freudenheim
J L
JL
Shields
P G
PG
Schisterman
E F
EF
Graham
S
S
Vena
J E
JE
Marshall
J R
JR
Ambrosone
C B
CB
D000022:Abortion, Spontaneous / Q000453:epidemiology* / Q000209:etiology; D000328:Adult; D000368:Aged; D001191:Arylamine N-Acetyltransferase / Q000235:genetics*; D005260:Female; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D017720:Molecular Epidemiology; D009153:Mutagens / Q000378:metabolism; D011110:Polymorphism, Genetic; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*
D009153:Mutagens; D001191:Arylamine N-Acetyltransferase; D005982:Glutathione Transferase