title: Quantitative trait loci implicated in corpus callosum midsagittal area in mice.
abstract: The midsagittal area of the corpus callosum expressed as the percentage of the hemispheric surface is smaller in the NZB/BlNJ than in the C57BL/6By inbred strain of mice. We performed a QTL mapping analysis using 284 F2s. Two loci linked to this measure were found: the CCrSQTL1 and CCrSQTL2 at 87 and 67 centiMorgans from the centromere on chromosomes 1 and 4 respectively. The two loci interacted significantly. The total source of genetic variation contributed to 25% of the observed variance.
authors.affiliation: UPR CNRS 9074, Génétique, Neurogénétique, Comportement, Institut de Transgénose, CNRS, 3 B Rue de la Ferollerie, 45071, Orléans Cedex 02, France.
authors.forename: I L
authors.initials: IL
authors.lastname: Roy
authors.forename: F
authors.initials: F
authors.lastname: Perez-Diaz
authors.forename: P
authors.initials: P
authors.lastname: Roubertoux
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D020090:Chromosome Segregation; D003337:Corpus Callosum / Q000502:physiology*; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D019655:Quantitative Trait, Heritable