Fluvoxamine-induced erectile dysfunction responding to sildenafil.
Sildenafil, a peripherally acting inhibitor of cyclic guanosine monophosphate((cGMP), has been reported highly effective in treating erectile dysfunction of various etiology. Erectile dysfunction is a common sexual side effect of various antidepressants. Various agents have been used in the treatment of antidepressant-induced erectile dysfunction; however, there are no reports on the use of sildenafil for this indication. This case report describes the successful use of sildenafil in fluvoxamine-induced erectile dysfunction. A possible mechanism of action of sildenafil in this type of erectile dysfunction is discussed.
Balon
R
R
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan, USA.
D000328:Adult; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D016666:Fluvoxamine / Q000009:adverse effects*; D006801:Humans; D008297:Male; D010410:Penile Erection / Q000187:drug effects*; D010879:Piperazines / Q000494:pharmacology* / Q000627:therapeutic use*; D011687:Purines; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*; D012735:Sexual Dysfunction, Physiological / Q000139:chemically induced* / Q000188:drug therapy*; D000068677:Sildenafil Citrate; D013450:Sulfones
D004791:Enzyme Inhibitors; D016666:Fluvoxamine; D010879:Piperazines; D011687:Purines; D017367:Selective Serotonin Reuptake Inhibitors; D000068677:Sildenafil Citrate; D013450:Sulfones