title: Glandular odontogenic cyst (sialo-odontogenic cyst): report of two cases and literature review of 45 previously reported cases.
abstract: The clinical, radiological, histopathological and immunohistochemical (cytokeratin) features of two cases of glandular odontogenic cyst (GOC) are presented and discussed in a review of 45 cases of GOC hitherto reported. Of cases with available information, 34 occurred in the mandible and 6 in the maxilla; the male:female ratio was 19:28, and the mean age was 46.7 years in males and 50.0 years in females. Six cysts recurred once after 2-8 years (mean 2 years 8 months) and 2 (5.3%) recurred twice after 2 and 5 years and after 3 and 5 years, respectively, giving a rate of recurrence of 21%. The identification of osteodentin in one of the present cases and the co-expression of cytokeratins (CK) 13, 19 and 8 strongly support the concept of odontogenic differentiation in the GOC. Careful surgical removal of the lesion succeeded by a 5-year follow-up period is recommended.
authors.affiliation: Department of Oral Pathology, Dental Faculty, University of Oslo, Norway.
authors.forename: H S
authors.initials: HS
authors.lastname: Koppang
authors.forename: S
authors.initials: S
authors.lastname: Johannessen
authors.forename: L K
authors.initials: LK
authors.lastname: Haugen
authors.forename: H R
authors.initials: HR
authors.lastname: Haanaes
authors.forename: T
authors.initials: T
authors.lastname: Solheim
authors.forename: K
authors.initials: K
authors.lastname: Donath
mesh_terms: D000328:Adult; D000368:Aged; D003238:Connective Tissue / Q000473:pathology; D003593:Cytoplasm / Q000648:ultrastructure; D004848:Epithelium / Q000473:pathology; D005347:Fibroblasts / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008297:Male; D008336:Mandibular Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D008439:Maxillary Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D009077:Mucins / Q000032:analysis; D009807:Odontogenic Cysts / Q000000981:diagnostic imaging / Q000473:pathology*; D011859:Radiography
chemical_list: D009077:Mucins; D007633:Keratins