title: [The immunogenicity of the Heberbiovac-HB vaccine in children].
abstract: The Cuban recombinant vaccine against hepatitis B virus was applied with doses of 10 ìg to children under 15 in a scheme from 0, 1 to 6 months. The immunogenicity was evaluated at 2, 7, and 12 months and showed 100% of seroconversion with protective titres. 65.9, 100, and 83.5% of the vaccinated attained titres higher that 100 UI/L at 60, 210, and 360 days. The geometrical mean was of 213.6, 8208.2, and 568.0 UI/L, respectively. All the groups obtained 100% of seroconversion; however, there were significant differences (p < 0.05) in favor of the preschool and school children compared with those over 10 as regards the response level (titres higher than 100 UI/L) and the geometrical mean of antibody titres in the 3 samples. It was demonstrated the high immunogenic power of the vaccine at these ages, which makes it recommendable for their protection against the hepatitis B virus (HBV).
authors.affiliation: Instituto de Medicina Tropical Pedro Kourí.
authors.forename: M
authors.initials: M
authors.lastname: Díaz González
authors.forename: A
authors.initials: A
authors.lastname: Chiang Macía
authors.forename: D
authors.initials: D
authors.lastname: Díaz Acosta
authors.forename: J R
authors.initials: JR
authors.lastname: Bravo González
authors.forename: L
authors.initials: L
authors.lastname: Rodríguez Lay
authors.forename: P
authors.initials: P
authors.lastname: Pedroso Flaquet
authors.forename: A U
authors.initials: AU
authors.lastname: López-Chávez
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D016001:Confidence Intervals; D003462:Cuba; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control; D006510:Hepatitis B Antibodies / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D017325:Hepatitis B Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006801:Humans; D007115:Immunization Schedule; D008297:Male; D013997:Time Factors; D019444:Vaccines, DNA / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D019444:Vaccines, DNA