title: [Dexpanthenol nasal spray as an effective therapeutic principle for treatment of rhinitis sicca anterior].
abstract: BACKGROUND
  Controlled clinical studies on medical treatment of rhinitis sicca anterior have not yet been published. Therapy recommendations are based on experiences but not on results of controlled clinical studies. The aim of this study was to examine the efficacy and tolerance of a new form of application of Dexpanthenol in physiologic saline solution (Nasicur).
  
  
  METHODS
  A randomized comparison of parallel groups was performed. One group was treated with the nasal spray while the control group received a placebo. The assessment of nasal breathing resistance and the extent of crust formation according to scores were defined as target parameters. Statistical analysis was carried out according to Wilcoxon at alpha < or = 0.05.
  
  
  RESULTS
  Forty-eight outpatients diagnosed with rhinitis sicca anterior were included in this study. Twenty-four received the medication, and 29 were treated with a placebo. The superiority of the dexpanthenol nasal spray in comparison to the placebo medication was demonstrated for both target parameters as clinically relevant and statistically significant. The placebo spray showed clinical improvement of the other treatment outcome parameters. Dexpanthenol nasal spray showed no statistically significant difference in comparison to placebo. The clinically proven efficacy is emphasized by good tolerance of both treatments which was validated by the objective rhinoscopy findings. Good compliance was confirmed.
  
  
  CONCLUSIONS
  The result of the controlled clinical study confirms that the dexpanthenol nasal spray is an effective medicinal treatment of rhinitis sicca anterior and is more effective than common medications.
authors.affiliation: Hals-Nasen-Ohrenklinik, Universitätskrankenhauses Hamburg-Eppendorf.
authors.forename: W
authors.initials: W
authors.lastname: Kehrl
authors.forename: U
authors.initials: U
authors.lastname: Sonnemann
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D000403:Airway Resistance / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009300:Nasal Septum; D010205:Pantothenic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D012220:Rhinitis / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D010205:Pantothenic Acid; C007288:dexpanthenol