De novo desmoplastic neurotropic melanoma of the lower lip: a neoplasm with ominous behavior.
Desmoplastic neurotropic melanoma represents a rare histologic variant of malignant melanoma that is characterized by a proliferation of spindle cells in a densely collagenous stroma with pronounced neurotropism. A 60-year-old man appeared for evaluation of a mass in the lower lip. The labial mucosa was intact, and the lesion had been present for 2 months. The tumor was surgically removed, and after immunohistochemical and ultrastructural analysis it was diagnosed as desmoplastic neurotropic melanoma. The tumor recurred 6 months later, with involvement of the inferior alveolar nerve.
Madrigal
B
B
Hospital Covadonga (HCA), University of Oviedo.
Fresno
M F
MF
Junquera
L
L
Veiga
M
M
Ablanedo
P
P
Herrero
A
A
D003390:Cranial Nerve Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D008048:Lip Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008340:Mandibular Nerve / Q000473:pathology*; D008545:Melanoma / Q000473:pathology* / Q000648:ultrastructure; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local