Karyotype analysis in chronic myelogenous leukemia. A three-year experience at the American University of Beirut Medical Center (AUBMC).
We report the results of karyotype analysis on cases referred to our laboratory for chronic myelogenous leukemia (CML) over a period of three years. A total of 68 patient were referred and a karyotype was successfully obtained in all cases except one. Thirty-one percent of cases were found to have a normal karyotype, 58.5% were Philadelphia (Ph1) positive while 10.5% of cases had chromosome abnormalities other than Ph1. Among the Ph1 positive cases, 92% had the standard translocation (9;22), 7.7% had a variant translocation and 12.8% had additional chromosome abnormalities. Our results are compared to those generally reported in the literature and the comparisons are discussed.
el-Assaad
W
W
Department of Laboratory Medicine, American University of Beirut Medical Center, Lebanon.
al-Oreibi
G
G
Zahed
L
L
D000328:Adult; D002869:Chromosome Aberrations / Q000175:diagnosis / Q000235:genetics*; D025063:Chromosome Disorders; D005260:Female; D006785:Hospitals, University; D006801:Humans; D007621:Karyotyping; D007861:Lebanon; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis / Q000235:genetics*; D054438:Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D012017:Referral and Consultation; D014178:Translocation, Genetic