[Extracellular matrix components in leiomyosarcoma].
This report describes the glycosaminoglycans, collagen and elastin--composition of leiomyosarcoma. Studies were performed on leiomyosarcoma removed during surgery. The material was taken from 7 patients. Rearrangement of extracellular matrix in leiomyosarcoma has been found. There was an increase of total collagen content in comparison to control uterus. In both tissues type I collagen was found to be the predominant one. Both tissues, normal and neoplastic contain all known glycosaminoglycans types. Among them heparan sulphate was found to be the most abundant. A slight decrease in the content of this glycosaminoglycan was observed in leiomyosarcoma. A possible role of these alterations in tumour biology is discussed.
Sobolewski
K
K
Zakładu Biochemii Akademii Medycznej w Białymstoku.
Wolańska
M
M
Drozdzewicz
M
M
D000328:Adult; D003094:Collagen / Q000032:analysis; D004549:Elastin / Q000032:analysis; D005260:Female; D006025:Glycosaminoglycans / Q000032:analysis; D006801:Humans; D007890:Leiomyosarcoma / Q000737:chemistry* / Q000601:surgery; D013431:Sulfates / Q000032:analysis; D002583:Uterine Cervical Neoplasms / Q000737:chemistry* / Q000601:surgery
D006025:Glycosaminoglycans; D013431:Sulfates; D003094:Collagen; D004549:Elastin