title: One normal child and a chromosomally balanced/normal twin after intracytoplasmic sperm injection in a male with a de-novo t(Y;16) translocation.
abstract: A balanced translocation t(Y;16)(q11.21;q24) is described in a male with severe oligoasthenoteratozoospermia (OAT). Before having a chromosome investigation, the patient and his partner had undergone intracytoplasmic sperm injection (ICSI) treatment resulting in the birth of a healthy 46,XX child. After detection of the t(Y;16) translocation, the couple opted for further ICSI treatment, although they were extensively counselled on the risk of having chromosomally unbalanced offspring. This treatment resulted in a twin pregnancy, one with a 46,XX karyotype and the other a 46,X,t(Y;16) (q11.21;q24) karyotype, the same as the father. After an uncomplicated pregnancy two healthy children were born. We conclude that patients with a Y/autosome translocation as a cause of OAT can have chromosomally normal children after ICSI treatment.
authors.affiliation: Clinical Genetics Center, Utrecht, The Netherlands.
authors.forename: J C
authors.initials: JC
authors.lastname: Giltay
authors.forename: C H
authors.initials: CH
authors.lastname: Tiemessen
authors.forename: W G
authors.initials: WG
authors.lastname: van Inzen
authors.forename: J M
authors.initials: JM
authors.lastname: Scheres
mesh_terms: D000328:Adult; D002871:Chromosome Banding; D002885:Chromosomes, Human, Pair 16; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009845:Oligospermia / Q000235:genetics* / Q000628:therapy*; D011247:Pregnancy; D011256:Pregnancy Outcome; D014178:Translocation, Genetic; D014429:Twins, Dizygotic; D014998:Y Chromosome