title: Daytime CPAP titration: a viable alternative for patients with severe obstructive sleep apnea.
abstract: OBJECTIVE
  Continuous positive airway pressure (CPAP) is the treatment of choice for patients diagnosed with severe obstructive sleep apnea (OSA). The implementation of CPAP therapy has traditionally been based on full-night titration studies or split-night protocols. This study compared a group of patients who received a regular nocturnal CPAP titration with patients who received a daytime CPAP titration. The objective of the study was to determine if daytime CPAP titration is a viable alternative for the implementation of CPAP treatment in patients with severe OSA.
  
  
  METHODS
  Fourteen patients (13 men and one woman) received a daytime CPAP titration (day group). The day group was matched to 18 patients (17 men and one woman) who were titrated under a full-night regular nocturnal study (night group). Eligible patients were those with severe OSA (respiratory event index > 40). The groups were matched by age, sex, and body mass index.
  
  
  RESULTS
  Daytime and nocturnal CPAP titration studies yielded sufficient amounts of rapid eye movement (REM) and non-REM sleep to help determine CPAP settings. Importantly, the diurnal and nocturnal CPAP titrations resulted in comparable therapeutic pressures as well as comparable resolution of sleep-disordered breathing. After 1 week of treatment, the groups exhibited similar CPAP use and comparable improvements in subjective sleepiness as indicated by their increase in sleep/wake activity inventory scores.
  
  
  CONCLUSIONS
  Daytime CPAP titration studies may be a viable alternative for the efficient and expedient implementation of CPAP therapy among some patients with severe OSA.
authors.affiliation: Sleep Disorder and Research Center, Henry Ford Hospital, Detroit, MI, USA. lronca@aol.com
authors.forename: L
authors.initials: L
authors.lastname: Rosenthal
authors.forename: K
authors.initials: K
authors.lastname: Nykamp
authors.forename: P
authors.initials: P
authors.lastname: Guido
authors.forename: M L
authors.initials: ML
authors.lastname: Syron
authors.forename: R
authors.initials: R
authors.lastname: Day
authors.forename: M
authors.initials: M
authors.lastname: Rice
authors.forename: T
authors.initials: T
authors.lastname: Roth
mesh_terms: D000328:Adult; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D011175:Positive-Pressure Respiration / Q000379:methods; D012189:Retrospective Studies; D012891:Sleep Apnea Syndromes / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D012895:Sleep, REM; D011795:Surveys and Questionnaires; D016896:Treatment Outcome