title: Effects of gabapentin on cognition and quality of life in patients with epilepsy.
abstract: The effect of gabapentin on cognition and quality of life (QoL) in patients with epilepsy was investigated using a controlled pre- and post-treatment design. Thirty patients with chronic epilepsy were administered a battery of cognitive tests and QoL measures at baseline (pre-treatment) and again following 1-2 months of treatment (post-treatment). All patients were receiving anticonvulsant medication at baseline. Following baseline assessment, 15 patients were started on gabapentin as add-on therapy (gabapentin group), and 15 patients remained on stable medication (control group). No between-group treatment effects were demonstrated on any of the mood measures. A significant between-group treatment effect was demonstrated on one cognitive measure, in favour of the gabapentin group. Results do not suggest any adverse short-term effects of gabapentin on cognition or QoL in patients with chronic epilepsy.
authors.affiliation: Department of Clinical Neurology, Institute of Neurology, University of London, UK.
authors.forename: C
authors.initials: C
authors.lastname: Mortimore
authors.forename: M
authors.initials: M
authors.lastname: Trimble
authors.forename: E
authors.initials: E
authors.lastname: Emmers
mesh_terms: D000085:Acetates / Q000494:pharmacology* / Q000627:therapeutic use; D000328:Adult; D000339:Affect / Q000187:drug effects; D000368:Aged; D000588:Amines; D000927:Anticonvulsants / Q000494:pharmacology* / Q000627:therapeutic use; D003071:Cognition / Q000187:drug effects*; D003509:Cyclohexanecarboxylic Acids; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D000077206:Gabapentin; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011788:Quality of Life; D012640:Seizures / Q000517:prevention & control; D018709:Statistics, Nonparametric; D005680:gamma-Aminobutyric Acid
chemical_list: D000085:Acetates; D000588:Amines; D000927:Anticonvulsants; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin