title: DNA end-joining: from yeast to man.
abstract: DNA non-homologous end-joining (NHEJ) is a crucial process that has been conserved highly throughout eukaryotic evolution. At its heart is a multiprotein complex containing the KU70-KU80 heterodimer. Recent work has identified additional proteins involved in this pathway, providing insights into the mechanism of NHEJ and revealing exciting links with the control of transcription, telomere length and chromatin structure.
authors.affiliation: Wellcome/CRC Institute, Cambridge, UK.
authors.forename: S E
authors.initials: SE
authors.lastname: Critchlow
authors.forename: S P
authors.initials: SP
authors.lastname: Jackson
mesh_terms: D034961:Antigens, Nuclear; D004247:DNA / Q000235:genetics / Q000378:metabolism*; D004265:DNA Helicases; D004260:DNA Repair; D004271:DNA, Fungal / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D006801:Humans; D000072200:Ku Autoantigen; D008954:Models, Biological; D009687:Nuclear Proteins / Q000378:metabolism; D010446:Peptide Fragments; D010455:Peptides / Q000378:metabolism; D011333:Pro-Opiomelanocortin / Q000378:metabolism; D011995:Recombination, Genetic; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins; D016615:Telomere / Q000378:metabolism
chemical_list: D034961:Antigens, Nuclear; D004271:DNA, Fungal; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D010446:Peptide Fragments; D010455:Peptides; D029701:Saccharomyces cerevisiae Proteins; C081647:high affinity DNA-binding factor, S cerevisiae; C078895:joining peptide, pro-opiomelanocortin; D011333:Pro-Opiomelanocortin; D004247:DNA; D004265:DNA Helicases; C106893:XRCC5 protein, human; C000606509:Xrcc6 protein, human; D000072200:Ku Autoantigen