A transcription factor party during blood cell differentiation.
Recent studies have shown that hematopoietic transcription factors can engage in multiple protein-protein interactions. Accumulating evidence indicates that specific complexes define differentiation lineages and differentiation stages. It is proposed that these complexes acquire new functions during blood cell differentiation through successive changes in composition - much as discussion topics of groups at a cocktail party take new directions as new people join and others leave.
Sieweke
M H
MH
European Molecular Biology Laboratory, Meyerhofstr. 1, 69117, Heidelberg, Germany. Sieweke@EMBL-Heidelberg.de
Graf
T
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D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000502:physiology; D002454:Cell Differentiation; D004920:Erythropoiesis / Q000235:genetics / Q000502:physiology; D006410:Hematopoiesis / Q000235:genetics / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000502:physiology*; D008954:Models, Biological; D014157:Transcription Factors / Q000378:metabolism*
D014157:Transcription Factors