title: Contrast sensitivity in obese dyslipidemic patients with insulin resistance.
abstract: OBJECTIVE
  To evaluate contrast sensitivity in insulin-resistant obese patients and in aretinopathic diabetic patients.
  
  
  METHODS
  Contrast sensitivity was measured at 3 letter sizes (44 x 44, 9 x 9, and 5 x 5 mm) in mesopic (5 candela [cd]/m2) and low photopic (85 cd/m2) vision in 20 dyslipidemic obese patients with insulin resistance, 20 age-matched patients with type 2 diabetes mellitus, and 20 aged-matched healthy control subjects.
  
  
  RESULTS
  Significant loss of contrast sensitivity at all 3 letter sizes was observed in low photopic vision (at 44 x 44-mm letter size, control vs obese, P<.002, and control vs diabetic, P<.005; at 9 x 9-mm letter size, control vs obese, P<.02, and control vs diabetic, P<.001; and at 5 x 5-mm letter size, control vs obese, P<.05, and control vs diabetic, P<.005) and mesopic vision (at 44 x 44-mm letter size, control vs diabetic, P<.005; at 9 x 9-mm letter size, control vs obese, P<.005, and control vs diabetic, P<.01; and at 5 x 5-mm letter size, control vs obese, P<.005, and control vs diabetic, P<.001) in insulin-resistant obese and diabetic patients.
  
  
  CONCLUSIONS
  The results suggest that an early neurosensory dysfunction may occur without visible vascular involvement and without overt hyperglycemia.
authors.affiliation: University Eye Clinic, Geneva, Switzerland. dosso-andre@diogenes.hcuge.ch
authors.forename: A A
authors.initials: AA
authors.lastname: Dosso
authors.forename: F
authors.initials: F
authors.lastname: Yenice-Ustun
authors.forename: J
authors.initials: J
authors.lastname: Sommerhalder
authors.forename: A
authors.initials: A
authors.lastname: Golay
authors.forename: Y
authors.initials: Y
authors.lastname: Morel
authors.forename: P M
authors.initials: PM
authors.lastname: Leuenberger
mesh_terms: D000328:Adult; D000368:Aged; D015350:Contrast Sensitivity / Q000502:physiology*; D003920:Diabetes Mellitus / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology; D006801:Humans; D006949:Hyperlipidemias / Q000503:physiopathology*; D007333:Insulin Resistance; D008875:Middle Aged; D009765:Obesity; D012160:Retina / Q000503:physiopathology; D014786:Vision Disorders / Q000175:diagnosis