title: Limb girdle muscular dystrophy type 2A (CAPN3): mapping using allelic association.
abstract: Recently a graphical study of linkage disequilibrium around the CAPN3 locus failed to refine the 1.3-Mb interval suggested by haplotype sharing. On the contrary, the Malecot model as implemented in the ALLASS program maps CAPN3 within 3 kb of its true location (23 kb from the locus midpoint), overcoming identified problems with small samples, interrelated sibships, and short duration.
authors.affiliation: Human Genetics, University of Southampton, Princess Anne Hospital, Southampton, UK. arc@soton.ac.uk
authors.forename: C
authors.initials: C
authors.lastname: Lonjou
authors.forename: A
authors.initials: A
authors.lastname: Collins
authors.forename: J
authors.initials: J
authors.lastname: Beckmann
authors.forename: V
authors.initials: V
authors.lastname: Allamand
authors.forename: N
authors.initials: N
authors.lastname: Morton
mesh_terms: D000483:Alleles; D002154:Calpain / Q000235:genetics*; D005808:Genes, Recessive; D005819:Genetic Markers; D006801:Humans; D007527:Isoenzymes; D015810:Linkage Disequilibrium; D008957:Models, Genetic; D009124:Muscle Proteins; D009136:Muscular Dystrophies / Q000235:genetics*; D010446:Peptide Fragments / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D007527:Isoenzymes; D009124:Muscle Proteins; D010446:Peptide Fragments; C105884:CAPN3 protein, human; D002154:Calpain