Effects of Coriolus versicolor polysaccharides peptides on electric activity of mediobasal hypothalamus and on immune function in rats.
OBJECTIVE
The nervous mechanism of the immune potentiating effect of Coriolus versicolor polysaccharides peptides (PSP) was studied in Wistar rats.


METHODS
The unit discharge of the mediobasal hypothalamus (MBH) neurons was recorded extracellularly and the lymphocyte proliferation was measured.


RESULTS
PSP 1 g.kg-1 ig for 5 d increased the T-lymphocytes and promoted T-lymphocyte proliferation in spleen and peripheral blood. This promoting effect of PSP was blocked by MBH lesion. PSP increased the discharge frequency of MBH neurons, but no increase in discharge frequency was observed after treatment of PSP plus immune inhibitor, cyclosporin A.


CONCLUSIONS
MBH is involved in the immune-potentiating effect of PSP.
Yu
G D
GD
Laboratory of Neurobiology, Suzhou Medical College, China.
Yin
Q Z
QZ
Hu
Y M
YM
Yin
Z W
ZW
Gu
Z L
ZL
Qian
Z N
ZN
Qian
Z M
ZM
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004594:Electrophysiology; D005260:Female; D007031:Hypothalamus / Q000502:physiology*; D008297:Male; D015213:Neuroimmunomodulation / Q000187:drug effects*; D009474:Neurons / Q000502:physiology; D011124:Polyporaceae / Q000737:chemistry*; D011509:Proteoglycans / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013601:T-Lymphocytes / Q000166:cytology
D000276:Adjuvants, Immunologic; D011509:Proteoglycans; C093216:polysaccharide peptide