title: A model of activity-dependent formation of cerebellar microzones.
abstract: According to modern views of the cerebellum in motor control, each cerebellar functional unit, or microzone, learns how to execute predictive and coordinative control, based on long-term depression of the granule cell-Purkinje cell synapses. In the present paper, in light of recent experimental and theoretical studies on synaptic elimination and cerebellar motor learning, a model of the formation of cerebellar microzones by climbing fiber synaptic elimination is proposed. It is shown that competition for an activity-dependent supply of neurotrophic factor can reproduce the spatio-temporal characteristics of climbing fiber synaptic elimination. It is further shown that when this elimination is accurate, motor coordination can be acquired in an arm reaching task. In view of the results of the present study, several predictions are proposed.
authors.affiliation: ERATO, Kawato Dynamic Brain Project, Japan Science and Technology Corporation, Kyoto, Japan. nicolas@erato.atr.co.jp
authors.forename: N
authors.initials: N
authors.lastname: Schweighofer
mesh_terms: D000328:Adult; D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D002525:Cerebellar Cortex / Q000502:physiology* / Q000648:ultrastructure; D004525:Efferent Pathways / Q000502:physiology; D006801:Humans; D007858:Learning / Q000502:physiology; D017774:Long-Term Potentiation / Q000502:physiology; D008959:Models, Neurological; D009043:Motor Activity / Q000502:physiology; D009412:Nerve Fibers / Q000502:physiology; D009414:Nerve Growth Factors / Q000502:physiology; D009847:Olivary Nucleus / Q000502:physiology; D011689:Purkinje Cells / Q000502:physiology; D012377:Rodentia / Q000033:anatomy & histology / Q000254:growth & development; D009435:Synaptic Transmission
chemical_list: D009414:Nerve Growth Factors