title: [A Spanish multicenter scintigraphic study of the breast using Tc 99m MIBI. Report of results].
abstract: The aim of this work has been to study, with a homogenous method, a wide sample of patients with breast cancer suspicion, in order to evaluate the real clinical usefulness of the scintimammography with MIBI-99mTc.
  
  
  METHODS
  We have studied by way of prone scintimammography 388 patients (418 lesions) with breast cancer suspicion. In the mammography the size and degree of breast cancer suspicion was evaluated. Diagnosis was established by biopsy.
  
  
  RESULTS
  247 lesions were diagnosed as breast cancer and 171 as benign diseases. She results of the scintimammography were sensitivity 90%, specificity 70%, PPV 81% and NPV 83%. In palpable lesions sensitivity and specificity were 94% and 61%, and in non-palpable lesions 75% and 81% respectively. In 264 lesions mammographic breast cancer suspicion was establish. 13 of the 14 FN results were obtained in lesions with a high malignancy suspicion. In lesions with a low or indeterminate suspicion, sensitivity and NPV of the scintimammography were 97% and 98%.
  
  
  CONCLUSIONS
  Scintimammography has a high sensitivity but a relatively low specificity in the study of lesions with breast cancer suspicion. Scintimammography could be a good complement of the mammography in lesions with a low or indeterminate suspicion of malignancy.
authors.affiliation: Servicio de Medicina Nuclear, Hospital Clínico Universitario,, Zaragoza, 50009, España.
authors.forename: E
authors.initials: E
authors.lastname: Prats
authors.forename: J
authors.initials: J
authors.lastname: Carril
authors.forename: R
authors.initials: R
authors.lastname: Herranz
authors.forename: E
authors.initials: E
authors.lastname: Meroño
authors.forename: J
authors.initials: J
authors.lastname: Banzo
authors.forename: Y E
authors.initials: YE
authors.lastname: Gtemegmmt
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001940:Breast / Q000000981:diagnostic imaging*; D001941:Breast Diseases / Q000000981:diagnostic imaging; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging*; D018275:Carcinoma, Lobular / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D005069:Evaluation Studies as Topic; D005260:Female; D018226:Fibroadenoma / Q000000981:diagnostic imaging; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D013030:Spain; D017256:Technetium Tc 99m Sestamibi
chemical_list: D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi