title: Long-term follow-up of patients enrolled in a randomized trial comparing perioperative chemotherapy and surgery with surgery alone in resectable stage IIIA non-small-cell lung cancer.
abstract: Our previously reported randomized study of patients with untreated, potentially resectable clinical stage IIIA non-small-cell lung cancer found that patients treated with perioperative chemotherapy and surgery had a significant increase in median survival compared to patients treated with surgery alone. We have now re-analyzed the results of the study with a median time from random allocation to analysis for all patients of 82 months. The increase in survival conferred by perioperative chemotherapy was maintained during the period of extended observation.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Roth
authors.forename: E N
authors.initials: EN
authors.lastname: Atkinson
authors.forename: F
authors.initials: F
authors.lastname: Fossella
authors.forename: R
authors.initials: R
authors.lastname: Komaki
authors.forename: M
authors.initials: M
authors.lastname: Bernadette Ryan
authors.forename: J B
authors.initials: JB
authors.lastname: Putnam
authors.forename: J S
authors.initials: JS
authors.lastname: Lee
authors.forename: H
authors.initials: H
authors.lastname: Dhingra
authors.forename: L
authors.initials: L
authors.lastname: De Caro
authors.forename: M
authors.initials: M
authors.lastname: Chasen
authors.forename: W K
authors.initials: WK
authors.lastname: Hong
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents