title: Variations in tumour oxygen tension (pO2) during accelerated radiotherapy of head and neck carcinoma.
abstract: The study was performed to assess the effect of accelerated radiotherapy on oxygenation of primary tumours and metastatic nodes in patients with advanced head and neck tumours. In 14 patients with head and neck tumour, oxygen tension (pO2) was evaluated in normal tissues and tumours (primary tumour or metastatic neck node) before (0 Gy) and after 2 weeks (32 Gy) of accelerated radiotherapy (70 Gy in 3.5 weeks, with three daily fractions). Radiotherapy was combined with carbogen breathing in 5 patients. pO2 was measured using a polarographic technique. For pooled normal tissues, median pO2 was 38 mmHg before treatment and 46 mmHg after 2 weeks. For tumours, very low values (< 2 mmHg) represented 20% of the recorded values before treatment and 10% after 2 weeks. The relative increase in tumour oxygenation was more pronounced for primary tumours (median pO2 12 mmHg before treatment versus 26 mmHg after 2 weeks, P < 0.05) than for metastatic nodes (respectively, 20 and 27 mmHg P = 0.1). For the 5 patients who breathed carbogen during accelerated radiotherapy, the median pO2 was 44 mmHg at 2 weeks, compared with 13.5 mmHg before treatment (P = 0.05). Very low pO2 values, corresponding to tumour hypoxia, were found in the tumours (primary and metastatic neck nodes) prior to accelerated treatment. During the first 2 weeks of accelerated treatment, an increase in median pO2 was found in nine of the 14 tumours, together with a decrease in the frequency of very low values.
authors.affiliation: Department of Radiotherapy, Institut Gustave Roussy, Villejuif, France.
authors.forename: E
authors.initials: E
authors.lastname: Lartigau
authors.forename: A
authors.initials: A
authors.lastname: Lusinchi
authors.forename: P
authors.initials: P
authors.lastname: Weeger
authors.forename: P
authors.initials: P
authors.lastname: Wibault
authors.forename: B
authors.initials: B
authors.lastname: Luboinski
authors.forename: F
authors.initials: F
authors.lastname: Eschwege
authors.forename: M
authors.initials: M
authors.lastname: Guichard
mesh_terms: D000368:Aged; D002245:Carbon Dioxide / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000737:chemistry / Q000532:radiotherapy*; D009959:Oropharyngeal Neoplasms / Q000737:chemistry / Q000532:radiotherapy*; D010100:Oxygen / Q000008:administration & dosage / Q000378:metabolism*; D010313:Partial Pressure
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen