title: Conservation of gene order: a fingerprint of proteins that physically interact.
abstract: A systematic comparison of nine bacterial and archaeal genomes reveals a low level of gene-order (and operon architecture) conservation. Nevertheless, a number of gene pairs are conserved. The proteins encoded by conserved gene pairs appear to interact physically. This observation can therefore be used to predict functions of, and interactions between, prokaryotic gene products.
authors.affiliation: European Molecular Biology Laboratory, Heidelberg, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Dandekar
authors.forename: B
authors.initials: B
authors.lastname: Snel
authors.forename: M
authors.initials: M
authors.lastname: Huynen
authors.forename: P
authors.initials: P
authors.lastname: Bork
mesh_terms: D019843:Archaeal Proteins / Q000737:chemistry / Q000235:genetics; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics; D019143:Evolution, Molecular; D019766:Genes, Archaeal; D005798:Genes, Bacterial; D005810:Multigene Family; D009876:Operon; D017510:Protein Folding
chemical_list: D019843:Archaeal Proteins; D001426:Bacterial Proteins