title: Beat averaging alternatives for transmitral Doppler flow velocity images.
abstract: To characterize diastolic function from transmitral Doppler data, the image's maximum velocity envelope (MVE) is fit by a model for flow velocity. To reduce the physiologic beat-to-beat variability of best-fit determined model parameters, averaging of multiple cardiac cycles is indicated. To assess variability mathematically, we modeled physiologic noise as a random (normally-distributed) process and evaluated three methods of averaging (1, averaging model parameters from single images; 2, averaging images; and 3, averaging MVEs) using clinical datasets (50 continuous beats from 5 subjects). Method 2 generates a positive bias because low-velocity beats will not contribute to the composite MVE. The difference between Methods 3 and 1 is less than 2.0 E-5 (m/s)2 for uncorrelated model parameters. Input having 10% beat-to-beat variation yields a bias of <4% for model parameter mean. Hence, Method 1 was, in general, more robust than Method 3.
authors.affiliation: Cardiovascular Division, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors.forename: A F
authors.initials: AF
authors.lastname: Hall
authors.forename: S P
authors.initials: SP
authors.lastname: Nudelman
authors.forename: S J
authors.initials: SJ
authors.lastname: Kovács
mesh_terms: D001783:Blood Flow Velocity; D003971:Diastole / Q000502:physiology; D015150:Echocardiography, Doppler; D006339:Heart Rate; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008943:Mitral Valve / Q000000981:diagnostic imaging*; D008962:Models, Theoretical; D012016:Reference Values; D016276:Ventricular Function