title: Differences of IgG and IgM antibodies to phospholipids and APTT among non-pregnant and pregnant women.
abstract: OBJECTIVE
  The objective of our study was to assess the difference in IgG and IgM antibodies to cardiolipin(CL), phosphatidylserine(PS), and APTT among non-pregnant and pregnant women.
  
  
  METHODS
  IgG and IgM antibodies to CL and PS among 102 healthy non-pregnant women and 154 healthy pregnant women were measured by an ELISA. The activated partial thromboplastin time(APTT) was measured in 67 healthy non-pregnant women, in 67 healthy women at 10-14 weeks of gestation, and in 67 healthy women at 30-32 weeks of gestation. We compared the titer of +2SD in each group.
  
  
  RESULTS
  The titers +2SD of IgG antibodies to CL and PS in pregnant women were lower than in non-pregnant women (p < 0.05), whereas the values of the IgM antibody to CL and PS were the same in pregnant and non-pregnant women. The APTT in pregnant women was significantly shorter than in non-pregnant women (p = 0.0001).
  
  
  CONCLUSIONS
  Standard criteria for the positivity of the IgG antibody to CL and PS and the prolongation of APTT in pregnancy should employ the values of normal pregnant women rather than those of non-pregnant women.
authors.affiliation: Department of Obstetrics and Gynecology, Otaru Kyokai Hospital, Hokkaido, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Shimano
authors.forename: T
authors.initials: T
authors.lastname: Kurosu
authors.forename: K
authors.initials: K
authors.lastname: Hayama
authors.forename: S
authors.initials: S
authors.lastname: Aoki
authors.forename: Y
authors.initials: Y
authors.lastname: Ishida
authors.forename: Y
authors.initials: Y
authors.lastname: Komae
mesh_terms: D000328:Adult; D001777:Blood Coagulation / Q000502:physiology; D002308:Cardiolipins / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology*; D007075:Immunoglobulin M / Q000097:blood / Q000276:immunology*; D010314:Partial Thromboplastin Time; D010718:Phosphatidylserines / Q000276:immunology; D010743:Phospholipids / Q000276:immunology*; D011247:Pregnancy / Q000097:blood* / Q000276:immunology*; D012016:Reference Values
chemical_list: D002308:Cardiolipins; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D010718:Phosphatidylserines; D010743:Phospholipids