title: Sarcoidosis associated with acute renal failure and increased levels of interleukin-6 in urine.
abstract: A 24-year-old man who had uveitis and showed intrathoracic lymph node swelling on a chest X-ray, was admitted to our hospital for further examination. Transbronchial lung biopsy specimens revealed non-caseating granulomas compatible to sarcoidosis. As the renal function became progressively worse, a specimen was obtained by renal biopsy. It showed a granuloma formation, and was diagnosed as renal sarcoidosis. A high level of interleukin (IL)-6 was detected in his urine. After oral administration of prednisolone, the renal function improved, and the urinary IL-6 level was reduced. These findings suggest that in sarcoidosis associated with renal failure, steroid therapy is effective and that IL-6 plays an important role in the pathogenesis of renal involvement of sarcoidosis.
authors.affiliation: Third Department of Internal Medicine, School of Medicine, Tokushima University.
authors.forename: K
authors.initials: K
authors.lastname: Maniwa
authors.forename: F
authors.initials: F
authors.lastname: Ogushi
authors.forename: T
authors.initials: T
authors.lastname: Haku
authors.forename: S
authors.initials: S
authors.lastname: Sone
authors.forename: Y
authors.initials: Y
authors.lastname: Ohmoto
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology* / Q000652:urine; D000328:Adult; D015415:Biomarkers; D006099:Granuloma / Q000209:etiology* / Q000652:urine; D006801:Humans; D007375:Interleukin-1 / Q000097:blood / Q000652:urine; D015850:Interleukin-6 / Q000097:blood / Q000652:urine*; D008297:Male; D012507:Sarcoidosis / Q000150:complications* / Q000652:urine; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis / Q000652:urine; D014786:Vision Disorders / Q000209:etiology
chemical_list: D015415:Biomarkers; D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha