Constitutional balanced pericentric inversions of chromosomes X, 2, and 5 in myeloid malignancies.
We report four cases of unrelated adult males carrying constitutive balanced pericentric inversions of chromosome X (one case), chromosome 2 (one case), and chromosome 5 (two cases) and presenting with myeloid malignancies. We discuss the potential contribution of these abnormalities to a background of susceptibility to hematologic malignancies.
Mozziconacci
M J
MJ
Institut Paoli-Calmettes, Hematological Cytogenetics Laboratory, Marseille, France.
Sobol
H
H
Philip
N
N
Stoppa
A M
AM
Brunel
V
V
Granel
B
B
Blaise
D
D
Sainty
D
D
Birnbaum
D
D
Lafage-Pochitaloff
M
M
D000328:Adult; D000754:Anemia, Refractory, with Excess of Blasts / Q000235:genetics*; D007446:Chromosome Inversion; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D017809:Fatal Outcome; D005819:Genetic Markers; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D015479:Leukemia, Myelomonocytic, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014960:X Chromosome / Q000235:genetics*
D005819:Genetic Markers