title: Histopathology of coronary lesions with early loss of minimal luminal diameter after successful percutaneous transluminal coronary angioplasty: is thrombus a significant contributor?
abstract: BACKGROUND
  Early loss of minimal luminal diameter of >0.3 mm after successful percutaneous transluminal coronary angioplasty (PTCA) is associated with a higher incidence of restenosis. The underlying mechanism of this early loss is unknown and thrombus may be a contributing factor.
  
  
  METHODS
  We performed a prospective study using quantitative computerized planimetry on coronary tissue specimens obtained by directional coronary atherectomy of 24 lesions in which early loss occurred 22+/-9 minutes after successful PTCA.
  
  
  RESULTS
  Thrombus was present in 9 (37%) of 24 coronary specimens. Segmental areas (mm2) and percentage of total area were distributed as follows: sclerotic tissue, 4.07+/-0.7 mm2 (63%+/-6%); fibrocellular tissue, 0.97+/-0.27 mm2 (16%+/-4%); hypercellular tissue, 0.99+/-0.29 mm2 (12%+/-3%); atheromatous gruel, 0.18+/-0.07 mm2 (3%+/-0.1%); and thrombus, 0.24+/-0.15 mm2 (6%+/-0.4%). There was no difference in the relative early loss index between lesions with or without thrombus (35%+/-7% vs 26%+/-2%, respectively; P= .87). Multiple stepwise regression analysis did not identify any histologic predictors of relative early loss index.
  
  
  CONCLUSIONS
  Histopathologic analysis of coronary lesions with early loss after successful PTCA suggests that thrombus may not play a significant role in this angiographic phenomenon.
authors.affiliation: Cardiac Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA.
authors.forename: P R
authors.initials: PR
authors.lastname: Moreno
authors.forename: J T
authors.initials: JT
authors.lastname: Fallon
authors.forename: V H
authors.initials: VH
authors.lastname: Bernardi
authors.forename: L
authors.initials: L
authors.lastname: Harrell
authors.forename: N J
authors.initials: NJ
authors.lastname: Weissman
authors.forename: V
authors.initials: V
authors.lastname: Fuster
authors.forename: A
authors.initials: A
authors.lastname: Rodríguez
authors.forename: I F
authors.initials: IF
authors.lastname: Palacios
mesh_terms: D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D015986:Confounding Factors, Epidemiologic; D003327:Coronary Disease / Q000209:etiology* / Q000473:pathology*; D003328:Coronary Thrombosis / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012008:Recurrence