Encouraging vaccine results from primate models of HIV type 1 infection.
Challenge studies in primates have established that vaccine-induced protection against immunodeficiency viruses, even against mucosal routes of challenge, is attainable, and that "sterile" immunity is not required for protection. Intelligent use of such studies in primate models, coupled with in vitro measurements of immunity, is the best tool for establishing which vaccine concepts have promise.
Schultz
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Vaccine and Prevention Research Program, Division of AIDS, NIAID, NIH, Rockville, Maryland 20892, USA.
D016915:AIDS Vaccines; D000818:Animals; D004195:Disease Models, Animal; D015658:HIV Infections / Q000276:immunology* / Q000517:prevention & control / Q000628:therapy; D015497:HIV-1 / Q000276:immunology; D011323:Primates
D016915:AIDS Vaccines