Escapable and inescapable stress differentially alter extracellular levels of 5-HT in the basolateral amygdala of the rat.
The effects of escapable and yoked inescapable electric tailshocks on extracellular levels of serotonin (5-HT) in the basolateral amygdala were measured by in vivo microdialysis. Inescapable, but not escapable, shock increased extracellular 5-HT in the amygdala relative to restrained controls. Basal levels of 5-HT were elevated 24 h after inescapable shock, and previously inescapably shocked subjects exhibited an exaggerated 5-HT response to two brief footshocks. Levels of extracellular 5-HIAA did not follow any particular pattern and were not correlated with the changes in 5-HT.
Amat
J
J
Instituto de Medicina Experimental, Universidad Central de Venezuela, Caracas, Venezuela.
Matus-Amat
P
P
Watkins
L R
LR
Maier
S F
SF
D000679:Amygdala / Q000378:metabolism*; D000704:Analysis of Variance; D000818:Animals; D003216:Conditioning, Operant / Q000502:physiology*; D004597:Electroshock; D004924:Escape Reaction / Q000502:physiology*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D017551:Microdialysis; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000378:metabolism*; D013312:Stress, Physiological / Q000378:metabolism*
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid