title: A transphyletic anti-infectious control strategy based on the killer phenomenon.
abstract: A strategy for the prevention and control of candidiasis, pneumocystosis, and tuberculosis, based on the idiotypic network of the yeast killer effect has been envisaged. Anti-idiotypic antibodies representing the internal image of a candidacidal, pneumocysticidal, and mycobactericidal killer toxin from Pichia anomala and idiotypes of killer toxin-neutralizing monoclonal antibodies mimicking the specific cell wall receptor of sensitive microorganisms might provide a unique approach for engineering innovative antibiotics and vaccines active against taxonomically unrelated pathogenic microorganisms. The rationale of the strategy relies on a phenomenon of microbial competition which has been mutated by the immune system in the response to natural infections.
authors.affiliation: Istituto di Microbiologia, Facoltà di Medicina e Chirugia, Università degli Studi di Parma, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Conti
authors.forename: W
authors.initials: W
authors.lastname: Magliani
authors.forename: M
authors.initials: M
authors.lastname: Gerloni
authors.forename: A
authors.initials: A
authors.lastname: Salati
authors.forename: E
authors.initials: E
authors.lastname: Dieci
authors.forename: S
authors.initials: S
authors.lastname: Arseni
authors.forename: P
authors.initials: P
authors.lastname: Fisicaro
authors.forename: L
authors.initials: L
authors.lastname: Polonelli
mesh_terms: D000818:Animals; D003001:Cloning, Molecular; D004337:Drug Carriers; D006801:Humans; D017053:Infection Control; D055646:Killer Factors, Yeast; D007778:Lactobacillus; D009161:Mycobacterium / Q000235:genetics; D009183:Mycotoxins / Q000235:genetics / Q000627:therapeutic use*; D010843:Pichia; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000627:therapeutic use; D019076:Transgenes
chemical_list: D004337:Drug Carriers; D055646:Killer Factors, Yeast; D009183:Mycotoxins; D011993:Recombinant Fusion Proteins; C087906:killer toxin, Pichia