Alloimmunization against human platelet antigen 2 (HPA2) in a series of multi-transfused beta-thalassemia patients.
In our study we investigated the presence of anti-human platelet antigen (HPA) alloantibodies in a series of 10 beta-thalassemia major patients submitted for more than 10 years to periodic blood transfusions (every 2-3 weeks). We found that 2 out of the 10 patients developed anti-HPA2a + HPA1b and anti-HPA2b antibodies. Our results highlight that HPA alloimmunization in multitransfused patients is a real possibility.
Tazzari
P L
PL
Ricci
F
F
Tassi
C
C
Bontadini
A
A
Fruet
F
F
Conte
R
R
D000328:Adult; D016824:Antigens, Human Platelet / Q000276:immunology*; D005260:Female; D005334:Fever / Q000209:etiology; D006801:Humans; D007114:Immunization; D007518:Isoantibodies / Q000096:biosynthesis* / Q000276:immunology; D008297:Male; D012768:Shivering; D065227:Transfusion Reaction; D017086:beta-Thalassemia / Q000276:immunology / Q000628:therapy*
C115212:2a alloantigen, human; C071221:2b alloantigen, human; D016824:Antigens, Human Platelet; D007518:Isoantibodies