title: Paravertebral muscles in experimental scoliosis: a light and electron microscopic study.
abstract: Experimental structural dextroconvex scoliosis was produced in rabbits by costotransversolisis with transversectomy and releasing of paravertebral muscles between TVII and TX on the right side. Two compensatory curves developed on the upper dorsal and lumbar levels. Biopsies of paravertebral muscles in experimental animals included, besides areas of normal tissue, a considerable derangement of the cell contractile apparatus with sarcoplasmic dilation and eventual cell disintegration and necrosis. Histological changes varied along levels, the convexity being more affected. The severity of changes and reduction in body weight and length were correlated with the degree of scoliosis. A selective atrophy of slow-twitch fibers was observed in experimental animals, especially at the level of the main curve, whereas fast-twitch fiber atrophy was more important caudally. Control animal biopsies always appeared normal. Our experimental model shows an overt participation of paravertebral muscles in the establishment of compensatory processes following scoliosis, although the role that paravertebral muscles play in the etiopathogenesis of human idiopathic scoliosis requires further investigation.
authors.affiliation: Department of Cell Biology, Faculty of Medicine, University of Valladolid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Garrosa
authors.forename: J R
authors.initials: JR
authors.lastname: Fernández-Mariño
authors.forename: M J
authors.initials: MJ
authors.lastname: Gayoso
authors.forename: M J
authors.initials: MJ
authors.lastname: Tomey
authors.forename: A
authors.initials: A
authors.lastname: al-Majdalawi
authors.forename: L P
authors.initials: LP
authors.lastname: Rodríguez
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D018482:Muscle, Skeletal / Q000473:pathology* / Q000648:ultrastructure; D011817:Rabbits; D011859:Radiography; D012600:Scoliosis / Q000000981:diagnostic imaging / Q000473:pathology*; D013131:Spine / Q000000981:diagnostic imaging