title: Effects of hormone replacement therapy on QT interval.
abstract: We evaluated the electrocardiograms of 208 postmenopausal women (ages 40 to > or = 70 years) without heart disease, medications that could alter the QT interval, use of vaginal estrogens, unknown hormone replacement therapy, or electrocardiographic abnormalities both with (n = 76) and without (n = 132) hormone replacement therapy, and found no significant effects of hormone replacement therapy status on heart rate, QT interval, or the corrected QT interval. Thus, estrogen and/or progesterone effect does not explain the gender differences in myocardial repolarization.
authors.affiliation: Department of Internal Medicine, Northwestern University Medical School, Chicago, Illinois, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Larsen
authors.forename: R H
authors.initials: RH
authors.lastname: Tung
authors.forename: R
authors.initials: R
authors.lastname: Sadananda
authors.forename: J J
authors.initials: JJ
authors.lastname: Goldberger
authors.forename: G
authors.initials: G
authors.lastname: Horvath
authors.forename: M A
authors.initials: MA
authors.lastname: Parker
authors.forename: A H
authors.initials: AH
authors.lastname: Kadish
mesh_terms: D000328:Adult; D000368:Aged; D004562:Electrocardiography / Q000187:drug effects*; D015914:Estrogen Replacement Therapy / Q000009:adverse effects*; D004967:Estrogens / Q000009:adverse effects*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause / Q000187:drug effects / Q000502:physiology; D011374:Progesterone / Q000627:therapeutic use; D012189:Retrospective Studies
chemical_list: D004967:Estrogens; D011374:Progesterone