[Expression of c-fos in spinal cord, medulla oblongata and thalamus following epicardial application of adenosine].
Effects of epicardial application of adenosine on the expression of c-fos proto-oncogene in spinal cord, medulla oblongata and thalamus were examined in 12 sinoaortic denervated and vagotomized anesthetized rats. The results showed that following epicardial application of adenosine the Fos-like protein immunoreactive (FLI) neurons were remarkably increased in the dorsal horn of T3 spinal segment, nucleus paragigantocellularis lateralis (PGL) of medulla oblongata, ventral postero-lateral thalamic nucleus (VPL), posterior thalamic nucleus (Po), parafascicular thalamic nucleus (PF) and centrolateral thalamic nucleus (CL), while the blood pressure and heart rate were not affected. Only a few FLI neurons were found in the vehicle-control rats. The results indicate that epicardial application of adenosine may activate the pain-related neurons in spinal cord, medulla oblongata and thalamus.
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Department of Physiology, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang.
Zhang
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He
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D000241:Adenosine / Q000494:pharmacology*; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D008297:Male; D008526:Medulla Oblongata / Q000378:metabolism*; D010496:Pericardium; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000378:metabolism*; D013788:Thalamus / Q000378:metabolism*
D000700:Analgesics; D016760:Proto-Oncogene Proteins c-fos; D000241:Adenosine