title: Neurological complications of radiotherapy and chemotherapy.
abstract: Neurological complications of radiotherapy and chemotherapy can affect the central or peripheral nervous system. Most are dose-dependent and constitute a limiting factor in the administration of treatments. Radiation-induced neurological complications are classified as acute, early-delayed or delayed. The most important are radionecrosis and cognitive dysfunction/leukoencephalopathy. Neurotoxicity of chemotherapy is frequent and depends upon dose, type of drugs (especially cisplatin and methotrexate) and their combination with radiotherapy.
authors.affiliation: Service de Neurologie, Hôpital de la Salpetrière, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Keime-Guibert
authors.forename: M
authors.initials: M
authors.lastname: Napolitano
authors.forename: J Y
authors.initials: JY
authors.lastname: Delattre
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D003071:Cognition / Q000187:drug effects; D016371:Cranial Irradiation / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D009422:Nervous System Diseases / Q000209:etiology* / Q000473:pathology; D011878:Radiotherapy / Q000009:adverse effects*; D013116:Spinal Cord / Q000528:radiation effects
chemical_list: D000970:Antineoplastic Agents