Anti-ischaemic effects of ACE inhibitors: review of current clinical evidence and ongoing clinical trials.
Important ongoing experimental and clinical research is evaluating the potential use of ACE inhibitors in a wider range of patients, in addition to their well accepted use in heart failure, left ventricular dysfunction and hypertension. We review briefly the clinical data supporting a potential role for ACE inhibitors in the prevention of myocardial infarction and stroke and the wider use of these agents in hypertension, renal disease and diabetes. We also briefly review the major ongoing trials evaluating these hypotheses.
Yusuf
S
S
McMaster University Division of Cardiology, Hamilton, Ontario, Canada.
Lonn
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D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000517:prevention & control; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000628:therapy; D011379:Prognosis; D012008:Recurrence
D000806:Angiotensin-Converting Enzyme Inhibitors