Methamphetamine--properties and analytical methods of enantiomer determination.
Methamphetamine is one of the most frequently abused drugs of today. Due to its stereogenic center, it can exist as single enantiomer. Like many other chiral compounds, methamamphetamine enantiomers exhibit different pharmacological effects on living organisms. For this reason, it is necessary to develop enantioselective and sufficiently sensitive methods of determination. This review focuses on methamphetamine with an accent on analytical chemistry and especially on chiral separations of this toxicologically important compound.
Jirovský
D
D
Laboratory of Bioanatytical Research, Palacký University, Olomouc, Czech Republic.
Lemr
K
K
Sevcík
J
J
Smysl
B
B
Stránský
Z
Z
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D019075:Electrophoresis, Capillary; D006801:Humans; D007118:Immunoassay; D008694:Methamphetamine / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D013237:Stereoisomerism
D008694:Methamphetamine