Factors influencing oral cavity status during high-dose antineoplastic therapy: a secondary data analysis.
OBJECTIVE
To identify factors associated with oral cavity status in patients receiving high-dose antineoplastic therapy.


METHODS
Descriptive, correlational secondary analysis.


METHODS
Midwestern university oncology special care unit.


METHODS
50 males and females, ages 15-69.


METHODS
The Oral Assessment Guide (OAG) was used to assess oral cavity status every shift throughout hospitalization. Additional data were collected by chart audit. Correlations and Cox regression analysis were performed.


METHODS
Oral cavity status, absolute granulocyte count, blood urea nitrogen (BUN), creatinine, mean OAG score during the preparative regimen (prep-OAG), age, and total body irradiation (TBI).


RESULTS
Elevated BUN and creatinine, higher prep-OAG, older age, and TBI were associated with higher OAG scores. Cox analysis revealed that TBI was predictive of an OAG score > or = 16, and an OAG score > or = 18 was predictive of death by day +20.


CONCLUSIONS
Patients who receive TBI and chemotherapy in combination are most likely to experience severely compromised oral cavity status. Those who are older, have poorer oral status, and have decreased renal function are at increased risk.


CONCLUSIONS
High-risk patients must be identified early, and oral assessments and care must be given consistently to decrease morbidity and potential mortality.
Berger
A M
AM
College of Nursing, University of Nebraska Medical Center, Omaha, USA.
Eilers
J
J
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa; D009730:Nursing Assessment; D009909:Oral Health; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D013280:Stomatitis / Q000139:chemically induced* / Q000451:nursing; D014916:Whole-Body Irradiation / Q000009:adverse effects
D000970:Antineoplastic Agents