B-type natriuretic peptide: a myocyte-specific marker for characterizing load-induced alterations in cardiac gene expression.
Atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP) and C-type natriuretic peptide are the known members of the mammalian natriuretic peptide system. ANP and BNP genes are expressed in a specific manner in cardiac myocytes. They are natriuretic and diuretic hormones and cause vasorelaxation. ANP is mainly synthesized in the atria of the normal adult heart. However, ventricular hypertrophy is characterized by an augmentation of the synthesis and release of ANP from the ventricles. BNP is expressed in both the atria and the ventricles, but is mainly released from the ventricles. The major determinant of ANP and BNP secretion is wall stretch, and the levels of BNP messenger RNA increase substantially in response to cardiac overload. Acute increase in BNP gene expression occurs within 1 h and mimics the rapid induction of proto-oncogenes in response to haemodynamic stress. BNP can be used as a myocyte-specific marker to identify mechanisms that couple acute mechanical overload to alterations in cardiac gene expression.
Magga
J
J
Department of Pharmacology and Toxicology, University of Oulu, Finland.
Vuolteenaho
O
O
Tokola
H
H
Marttila
M
M
Ruskoaho
H
H
D000328:Adult; D000818:Animals; D002306:Cardiac Volume / Q000502:physiology; D002478:Cells, Cultured; D002675:Child, Preschool; D004285:Dogs; D015870:Gene Expression; D005819:Genetic Markers / Q000502:physiology; D006162:Guanylate Cyclase / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000503:physiopathology*; D051379:Mice; D008822:Mice, Transgenic; D009206:Myocardium / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D017461:Receptors, Atrial Natriuretic Factor / Q000235:genetics* / Q000378:metabolism*; D012680:Sensitivity and Specificity; D013552:Swine
D005819:Genetic Markers; D006162:Guanylate Cyclase; D017461:Receptors, Atrial Natriuretic Factor; C073616:atrial natriuretic factor receptor C