title: Testicular germ cell tumors: molecular understanding and clinical implications.
abstract: It was recognized in the 1960s that testicular germ cell tumors were curable with chemotherapeutic drugs. Since that time, newer drugs including cisplatin have increased the cure rate of these tumors to over 80%, even in patients with metastatic disease. Germ cell tumors also exhibit a unique biology and genetics that distinguish them from other solid tumors and might contribute to their routine curability.
authors.affiliation: Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick 08901, USA.
authors.forename: S G
authors.initials: SG
authors.lastname: Lutzker
authors.forename: N J
authors.initials: NJ
authors.lastname: Barnard
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D017209:Apoptosis; D016147:Genes, Tumor Suppressor; D018237:Germinoma / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D006801:Humans; D008297:Male; D018239:Seminoma / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D013736:Testicular Neoplasms / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents