title: Regulation of gene expression by trans-synaptic activity: a role for the transcription factor NF-kappa B.
abstract: Earlier studies in the sympathetic ganglion have led to the proposal that adaptation of transcription to trans-synaptic activity is controlled by a signal transduction pathway featuring a transcription factor which translocates to the nucleus upon its release from the post-synaptic membrane by after-hyperpolarization. In light of recent progress, it is proposed here that NF-kappa B constitutes the postulated transcription factor.
authors.affiliation: Département de Pathologie et Biologie cellulaire, Université de Montréal, Québec, Canada.
authors.forename: V
authors.initials: V
authors.lastname: Gisiger
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology*; D016328:NF-kappa B / Q000502:physiology*; D009474:Neurons / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis; D015398:Signal Transduction / Q000502:physiology*; D013569:Synapses / Q000502:physiology*
chemical_list: D016328:NF-kappa B; D012313:RNA