[Effect of microinjection of GABA into the caudate nucleus on electrical discharges of nociceptive neurons in caudate nucleus of rat].
The characteristics of glass microelectrode recorded electrical activity of nociceptive neurons in the caudate nucleus elicited by microinjection of GABA and blockage by picrotoxin (PIC) were studied in 53 Wistar rats. The results showed that GABA (25, 50, 100 micrograms/2 microliters every 2 min) inhibited the activity of pain excitation neurons (PEN), as shown by decreased frequency and increased latency, but enhanced the activity of pian, inhibition neurons (PIN), as shown by shortened duration and increased discharge frequency. Both activities are highly dose-dependent and could be blocked by PIC (i.p. 250 micrograms, 1 ml/1 min).
Gu
R M
RM
Department of Physiology, Harbin Medical University.
Sun
M Z
MZ
Li
Y R
YR
Zhang
J Y
JY
Han
W M
WM
Liu
G
G
D000818:Animals; D002421:Caudate Nucleus / Q000502:physiology*; D004594:Electrophysiology; D005260:Female; D018756:GABA Antagonists / Q000494:pharmacology; D008297:Male; D008845:Microinjections; D009619:Nociceptors / Q000502:physiology*; D010852:Picrotoxin / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D018756:GABA Antagonists; D010852:Picrotoxin; D005680:gamma-Aminobutyric Acid