title: Effects of small doses of ionising radiation.
abstract: Uncertainty remains about the quantitative effects of doses of ionising radiation less than 0.2 Sv. Estimates of hereditary effects, based on the atomic bomb survivors, suggest that the mutation doubling dose is about 2 Sv for acute low LET radiation, but the confidence limits are wide. The idea that paternal gonadal irradiation might explain the Seascale cluster of childhood leukaemia has been disproved. Fetal irradiation may lead to a reduction in IQ and an increase in seizures in childhood proportional to dose. Estimates that doses to a whole population cause a risk of cancer proportional to dose, with 0.1 Sv given acutely causing a risk of 1%, will need to be modified as more information is obtained, but the idea that there is a threshold for risk above this level is not supported by observations on the irradiated fetus or the effect of fallout. The idea, based on ecological observations, that small doses protect against the development of cancer is refuted by the effect of radon in houses. New observations on the atomic bomb survivors have raised afresh the possibility that small doses may also have other somatic effects.
authors.affiliation: ICRF/MRC/BHF Clinical Trial Service Unit, Radcliffe Infirmary, Oxford, UK.
authors.forename: R
authors.initials: R
authors.lastname: Doll
mesh_terms: D004307:Dose-Response Relationship, Radiation; D005260:Female; D005333:Fetus / Q000528:radiation effects; D006801:Humans; D007953:Leukemia, Radiation-Induced; D008297:Male; D009381:Neoplasms, Radiation-Induced; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011829:Radiation Dosage; D011832:Radiation Injuries; D018570:Risk Assessment