title: Constitutional balanced pericentric inversions of chromosomes X, 2, and 5 in myeloid malignancies.
abstract: We report four cases of unrelated adult males carrying constitutive balanced pericentric inversions of chromosome X (one case), chromosome 2 (one case), and chromosome 5 (two cases) and presenting with myeloid malignancies. We discuss the potential contribution of these abnormalities to a background of susceptibility to hematologic malignancies.
authors.affiliation: Institut Paoli-Calmettes, Hematological Cytogenetics Laboratory, Marseille, France.
authors.forename: M J
authors.initials: MJ
authors.lastname: Mozziconacci
authors.forename: H
authors.initials: H
authors.lastname: Sobol
authors.forename: N
authors.initials: N
authors.lastname: Philip
authors.forename: A M
authors.initials: AM
authors.lastname: Stoppa
authors.forename: V
authors.initials: V
authors.lastname: Brunel
authors.forename: B
authors.initials: B
authors.lastname: Granel
authors.forename: D
authors.initials: D
authors.lastname: Blaise
authors.forename: D
authors.initials: D
authors.lastname: Sainty
authors.forename: D
authors.initials: D
authors.lastname: Birnbaum
authors.forename: M
authors.initials: M
authors.lastname: Lafage-Pochitaloff
mesh_terms: D000328:Adult; D000754:Anemia, Refractory, with Excess of Blasts / Q000235:genetics*; D007446:Chromosome Inversion; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D017809:Fatal Outcome; D005819:Genetic Markers; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D015479:Leukemia, Myelomonocytic, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014960:X Chromosome / Q000235:genetics*
chemical_list: D005819:Genetic Markers