title: Surgery for cholecystocholedocholithiasis in a patient with asymptomatic essential thrombocythemia: report of a case.
abstract: Essential thrombocythemia (ET) is a myeloproliferative disorder characterized by a remarkable increase in the platelet count and various clinical symptoms. The perioperative management of patients with ET has yet to be determined, especially when there are no clinical symptoms. We report herein the case of a woman with gallstones whose preoperative hematological data showed remarkable thrombocythemia, but her coagulation studies were normal. The Philadelphia chromosome was negative and bone marrow cytology showed a marked increase in megakaryocytes. Surgery was performed under a diagnosis of cholelithiasis with ET. Considering her severe thrombocythemia and obesity, sufficient heparin was administered to prevent deep vein thrombosis; however, this precipitated postoperative bleeding, necessitating a reoperation. A functional abnormality of the patient's platelets was suspected, and the aggregation by adenosine diphosphate was subsequently found to be significantly inhibited. As patients having ET with no symptoms might have depressed platelet aggregability despite remarkable thrombocythemia, when abdominal surgery is performed, prophylactic therapy for deep vein thrombosis should be avoided. Hence, the preoperative aggregation study of platelets might offer useful information about whether postoperative antithrombotic therapy is indicated.
authors.affiliation: Department of Surgery, Himeji National Hospital, Hyogo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Wada
authors.forename: J
authors.initials: J
authors.lastname: Ryo
authors.forename: S
authors.initials: S
authors.lastname: Sarumaru
authors.forename: T
authors.initials: T
authors.lastname: Matsushita
authors.forename: H
authors.initials: H
authors.lastname: Isobe
authors.forename: B
authors.initials: B
authors.lastname: Sato
authors.forename: S
authors.initials: S
authors.lastname: Kanaya
authors.forename: T
authors.initials: T
authors.lastname: Katayama
authors.forename: M
authors.initials: M
authors.lastname: Ohtoshi
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects; D005260:Female; D042882:Gallstones / Q000150:complications* / Q000601:surgery*; D006470:Hemorrhage / Q000139:chemically induced; D006493:Heparin / Q000009:adverse effects; D006801:Humans; D008875:Middle Aged; D010974:Platelet Aggregation; D011183:Postoperative Complications; D013920:Thrombocythemia, Essential / Q000150:complications* / Q000503:physiopathology
chemical_list: D000925:Anticoagulants; D006493:Heparin