title: Expression of cyclin D1 and cyclin E in human gastric carcinoma and its clinicopathologic significance.
abstract: Cyclin D1 and cyclin E are the mammalian G1 cydins that are both required and rate limiting for entry into S phase. Alterations in cell cycle regulators and subsequent deregulation of the cell cycle are frequently involved in tumorigenesis and/or tumor progression. We investigated the expression of cyclin D1 and cyclin E protein in 84 gastric carcinoma by immunohistochemical staining and also the relevance of each cyclin expression to the clinical outcomes. Overexpression of cyclin D1 and cyclin E was noted in 21 of 84 (25.0%) and 34 of 84 (40.5%) gastric cancer tissues, respectively. There was a significant correlation between overexpression of cyclin E and lymph node metastasis (p=0.003), recurrence (p=0.043), disease free survival (p=0.0378) and overall survival (p=0.0319), but no correlation was noted between overexpression of cyclin D1 and other clinicopathologic variables. These findings suggest that overexpression of cyclin E and cyclin D1 is a frequent finding in gastric cancer and immunohistochemical analysis for cell cycle regulators, especially cyclin E might be a useful prognostic indicator in gastric cancer.
authors.affiliation: Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea. ahnmj@hanyang.ac.kr
authors.forename: M J
authors.initials: MJ
authors.lastname: Ahn
authors.forename: B H
authors.initials: BH
authors.lastname: Kim
authors.forename: S J
authors.initials: SJ
authors.lastname: Jang
authors.forename: E K
authors.initials: EK
authors.lastname: Hong
authors.forename: W M
authors.initials: WM
authors.lastname: Lee
authors.forename: H K
authors.initials: HK
authors.lastname: Baik
authors.forename: H K
authors.initials: HK
authors.lastname: Park
authors.forename: C B
authors.initials: CB
authors.lastname: Lee
authors.forename: M
authors.initials: M
authors.lastname: Ki
mesh_terms: D000328:Adult; D019938:Cyclin D1 / Q000096:biosynthesis*; D019927:Cyclin E / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D008297:Male; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D019927:Cyclin E; D019938:Cyclin D1