The evolution of self-tolerance: a new cell arises to meet the challenge of self-reactivity.
Naive T cells can become either tolerant or immune as a result of their first encounter with antigen. It has been suggested that lymphoid and myeloid dendritic cells, respectively, control such decisions. Here, Barbara Fazekas de St Groth discusses evolutionary aspects of the functional distinction between these two types of dendritic cells.
Fazekas de St Groth
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Centenary Institute of Cancer Medicine and Cell Biology, Newtown, NSW, Australia. B.Fazekas@centenary.usyd.edu.au
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology; D003713:Dendritic Cells / Q000145:classification / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D008221:Lymphoid Tissue / Q000166:cytology / Q000276:immunology*; D051379:Mice; D010802:Phylogeny; D017634:Self Tolerance / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology