[Calcium channel blocker].
In the treatment of coronary heart disease, augmentation of oxygen supply and reduction of oxygen demand are necessary. Calcium antagonists (CA) have potent coronary vasodilating (augmentation of oxygen supply) and hypotensive (reduction of oxygen demand) effects without serious side effects, and are most popular agents in the treatment of coronary heart disease (CHD) and hypertension. Short acting CA are reported to be risks for coronary heart disease presumably due to a steal phenomenon, a marked hypotensive effect, and an increased sympathetic nerve activity. Therefore, nowadays long acting CA are usually used in the treatment of CHD and hypertension. However, long term treatment effects of long acting CA in patients with CHD are not clear. Further clinical trials (including primary prevention) concerning long acting CA are needed.
Matsuoka
H
H
Department of Medicine (Hypertension and Cardiorenal Disease), Dokkyo University School of Medicine.
D000208:Acute Disease; D002121:Calcium Channel Blockers / Q000008:administration & dosage* / Q000009:adverse effects; D002986:Clinical Trials as Topic; D003327:Coronary Disease / Q000188:drug therapy* / Q000517:prevention & control; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D013564:Sympathetic Nervous System / Q000187:drug effects; D013577:Syndrome
D002121:Calcium Channel Blockers