title: Ureaplasma urealyticum reduces motility and induces membrane alterations in human spermatozoa.
abstract: The in-vitro effects of several concentrations of Ureaplasma urealyticum on the motility, membrane integrity and morphology of washed spermatozoa from healthy donors were studied. A significant reduction in sperm motility and signs of membrane alteration, directly related to U.urealyticum concentration and contact time were observed. Scanning electron microscopy examination showed masses of U. urealyticum attached to the head and middle piece of some of deformed spermatozoa. It is suggested that U.urealyticum is involved in sperm changes leading to male infertility, particularly when there is heavy U. urealyticum colonization or specific infections with this microorganism.
authors.affiliation: Department of Gynecology, Ramón y Cajal Hospital, Institute Nacional of Health, Madrid, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Núñez-Calonge
authors.forename: P
authors.initials: P
authors.lastname: Caballero
authors.forename: C
authors.initials: C
authors.lastname: Redondo
authors.forename: F
authors.initials: F
authors.lastname: Baquero
authors.forename: M
authors.initials: M
authors.lastname: Martínez-Ferrer
authors.forename: M A
authors.initials: MA
authors.lastname: Meseguer
mesh_terms: D001422:Bacterial Adhesion; D002463:Cell Membrane Permeability; D006801:Humans; D066298:In Vitro Techniques; D007248:Infertility, Male / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008855:Microscopy, Electron, Scanning; D009997:Osmotic Pressure; D013081:Sperm Motility; D013094:Spermatozoa / Q000382:microbiology* / Q000502:physiology / Q000648:ultrastructure; D016869:Ureaplasma Infections / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D016990:Ureaplasma urealyticum / Q000472:pathogenicity*