Betulinic acid inhibits aminopeptidase N activity.
The triterpene betulinic acid inhibits the activity of aminopeptidase N (EC 3.4.11.2) in a dose-dependent manner. An IC50 of 7.3 +/- 1.4 microM was determined for betulinic acid. This inhibitory activity is higher than that of bestatin' (IC50 = 16.9 +/- 4.1 microM), a well known inhibitor of this enzyme. The finding supports the idea that betulinic acid acts as anti-melanoma agent via inhibition of aminopeptidase N activity.
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Bormann
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D000276:Adjuvants, Immunologic / Q000494:pharmacology; D019380:Anti-HIV Agents / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D018826:CD13 Antigens / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D053978:Pentacyclic Triterpenes; D014315:Triterpenes / Q000494:pharmacology*; D000094062:Betulinic Acid
D000276:Adjuvants, Immunologic; D019380:Anti-HIV Agents; D000972:Antineoplastic Agents, Phytogenic; D004791:Enzyme Inhibitors; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; D018826:CD13 Antigens; D000094062:Betulinic Acid