[Tumor markers and TNM classification].
Some tumor markers were demonstrated as being significant prognostic factors of cancer patients and are proposed to be included in the TNM classification. However, only serum ALP fulfils the criteria in patients with osteosarcoma. The author proposes the concept of "cancer related molecular markers," including circulating tumor markers and genomic changes. Their messages and products should be evaluated if it is a major independent prognostic factor of a cancer and its assay is easy and reproducible.
Ohkura
H
H
Medical Oncology Division, Ibaraki Kenritsu Chuo Hospital & Cancer Center, Japan.
D000704:Analysis of Variance; D014408:Biomarkers, Tumor / Q000097:blood / Q000145:classification*; D006801:Humans; D009369:Neoplasms / Q000097:blood* / Q000235:genetics; D011379:Prognosis; D012306:Risk; D013274:Stomach Neoplasms / Q000097:blood / Q000401:mortality; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
D014408:Biomarkers, Tumor; D016159:Tumor Suppressor Protein p53