title: Gynecologic laparoscopic surgery is not associated with an increase of serotonin metabolites excretion.
abstract: Gynecologic laparoscopic surgery is associated with a high incidence of postoperative nausea and vomiting (PONV). The specific antagonists of the 5-hydroxytryptamine-3 (5-HT3) receptor have been progressively introduced in anesthesiology to prevent or treat PONV. Although a large increase of serotonin has been documented after cisplatin treatment, the link between serotonin and PONV in surgery/anesthesiology is unknown. In a prospective study, we compared the excretion of the serotonin metabolite 5-hydroxyindoacetic acid (5-HIAA) in 40 women undergoing either gynecologic laparoscopic surgery (laparoscopy group) or traditional open laparotomy surgery (laparotomy group). Premedication, anesthetic technique, and postoperative pain treatment were standardized. The excretion of 5-H IAA corrected to creatinine was measured in all patients immediately after the induction of anesthesia and was repeated regularly until 9 h after induction. The excretion of 5-HIAA/creatinine was similar in the two groups; no increase was observed in either group. The incidence of nausea and vomiting was 40% and 35%, respectively, in the laparoscopy group versus 60% and 15%, respectively, in the laparotomy group (not significantly different). The excretion of 5-HIAA/creatinine was comparable in patients of both groups among those who vomited and those who did not. We conclude that the creation of a pneumoperitoneum during gynecologic laparoscopic surgery is not associated with an increase of 5-HIAA excretion. PONV after gynecologic laparoscopic surgery is not explained by an increase of serotonin secretion.
  
  
  CONCLUSIONS
  The mechanism leading to the high incidence of postoperative nausea and vomiting after gynecologic laparoscopic surgery is unknown. The excretion of the serotonin metabolite 5-hydroxyindoacetic acid did not increase during the creation of the pneumoperitoneum and the first 9 h postoperatively. Increase of serotonin secretion from the gut may not explain postoperative nausea and vomiting associated with this surgery.
authors.affiliation: Department of Anesthesiology, Orthopedic University Clinic of Zurich/Balgrist, Zurich, Switzerland. aborgeat@balgrist.unizh.ch
authors.forename: A
authors.initials: A
authors.lastname: Borgeat
authors.forename: P
authors.initials: P
authors.lastname: Hasler
authors.forename: M
authors.initials: M
authors.lastname: Fahti
mesh_terms: D000328:Adult; D000368:Aged; D000701:Analgesics, Opioid / Q000627:therapeutic use; D005260:Female; D005283:Fentanyl / Q000627:therapeutic use; D013509:Gynecologic Surgical Procedures / Q000009:adverse effects*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000652:urine; D007828:Laryngoscopy / Q000009:adverse effects*; D008875:Middle Aged; D009020:Morphine / Q000627:therapeutic use; D020250:Postoperative Nausea and Vomiting / Q000652:urine*; D012701:Serotonin / Q000652:urine*
chemical_list: D000701:Analgesics, Opioid; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D009020:Morphine; D005283:Fentanyl