Dependence between dissolution rate and porosity of compressed erythromycin acistrate tablets.
The correlation between dissolution rate and porosity of compressed erythromycin acistrate tablets was studied. The total porosity of the tablets, the pore size distribution and the specific surface area of the pores were determined using high-pressure mercury porosimetry. The particle size and specific surface area of the raw material and of the dry granulated mass of the tablets were also determined. The results show that the pore size distribution, showing the differences in pore structure, is more informative than total intruded volume of mercury. However, it is very difficult to explain the dissolution behaviour of erythromycin acistrate tablets only by porosity results of the tablets, and more work is still needed in this field.
Riippi
M
M
Pharmaceutical Technology Division, University of Helsinki, Helsinki, Finland.
Yliruusi
J
J
Niskanen
T
T
Kiesvaara
J
J
D004917:Erythromycin / Q000031:analogs & derivatives* / Q000737:chemistry; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D008968:Molecular Conformation; D015394:Molecular Structure; D010316:Particle Size; D011355:Prodrugs / Q000737:chemistry*; D012995:Solubility; D013607:Tablets
D011355:Prodrugs; D013607:Tablets; D004917:Erythromycin; C056625:erythromycin 2'-acetate