title: Double malignant neoplasms occurring long after local radiation to the oral mucosa.
abstract: A 59-year-old woman who had received cobalt-60 (60Co) interstitial radiation therapy (total 44 Gy) in the right bucco-gingival region for inflammatory pseudotumour was found to have metachronous double malignant neoplasms. Initial osteosarcoma of the right mandibular angle and subsequent squamous cell carcinoma of the right buccal mucosa were identified 28 and 33 years after the radiation, respectively. Since both tumours were located very close to the focus of previous radiation, the therapy was considered to be responsible for their genesis. The patient had systemic metastases of the osteosarcoma.
authors.affiliation: Department of Oral Pathology, Tohoku University School of Dentistry, Sendai, Miyagi, Japan. onodera@opath.dent.tohoku.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Onodera
authors.forename: R
authors.initials: R
authors.lastname: Ichinohasama
authors.forename: K
authors.initials: K
authors.lastname: Ooya
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D003037:Cobalt Radioisotopes / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006104:Granuloma, Plasma Cell / Q000150:complications / Q000473:pathology / Q000532:radiotherapy; D006801:Humans; D008339:Mandibular Neoplasms / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D009059:Mouth Diseases / Q000150:complications / Q000473:pathology / Q000532:radiotherapy; D009061:Mouth Mucosa / Q000000981:diagnostic imaging / Q000528:radiation effects*; D009062:Mouth Neoplasms / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D009381:Neoplasms, Radiation-Induced / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D016609:Neoplasms, Second Primary / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D012516:Osteosarcoma / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D003037:Cobalt Radioisotopes