title: Regulatory targets in the RNA polymerase II holoenzyme.
abstract: The RNA polymerase II holoenzyme is the form of polymerase recruited to promoters for protein-coding genes. Several targets of mammalian activators, previously called coactivators, turn out to be subunits of the holoenzyme which activators use to recruit and regulate the holoenzyme. Several of these newly identified holoenzyme components have been implicated in human disease.
authors.affiliation: Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 20 Shattuck Street, Boston, Massachusetts 02115, USA. jparvin@rics.bwh.harvard.edu
authors.forename: J D
authors.initials: JD
authors.lastname: Parvin
authors.forename: R A
authors.initials: RA
authors.lastname: Young
mesh_terms: D000818:Animals; D004194:Disease; D005786:Gene Expression Regulation; D020035:Holoenzymes / Q000378:metabolism; D006801:Humans; D008957:Models, Genetic; D011401:Promoter Regions, Genetic; D012319:RNA Polymerase II / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D020035:Holoenzymes; D014157:Transcription Factors; D012319:RNA Polymerase II