title: [Infrared A radiation-controlled permeation of tetracaine in vitro and in vivo].
abstract: Waterfiltered infrared light (IR-A) was investigated as permeation enhancer for transdermal drug delivery systems on biological membranes. Due to the IR-A-radiation pulse on human keratinocytes (HaCaT) a clear increase in the permeability of tetracaine was recognizable. In vivo studies showed IR-A-supported enhanced local analgesia of tetracaine hydrogel in the pin prick test. The study leads to the conclusion, that IR-A-radiation can specifically be used to optimize transdermal drug permeation.
authors.affiliation: Institut für Pharmazie, Johannes Gutenberg-Universität Mainz, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Haupenthal
authors.forename: F
authors.initials: F
authors.lastname: Moll
mesh_terms: D000279:Administration, Cutaneous; D000779:Anesthetics, Local / Q000493:pharmacokinetics*; D002463:Cell Membrane Permeability / Q000528:radiation effects; D002478:Cells, Cultured; D006801:Humans; D007259:Infrared Rays; D015603:Keratinocytes / Q000528:radiation effects; D008422:Materials Testing; D013748:Tetracaine / Q000493:pharmacokinetics*
chemical_list: D000779:Anesthetics, Local; D013748:Tetracaine