Reduced plasma c-AMP levels in children with atopic dermatitis.
Plasma levels of cAMP and serum concentrations of IgE have been determined in children with acute atopic dermatitis (AD) and in a healthy control group, to illuminate the pathophysiological mechanisms that cause AD. There were significantly lower plasma levels of cAMP (P < 0.001) and significantly higher levels of serum IgE (P < 0.004) in children with AD, in comparison with a healthy control group. It is possible that defective control of c-AMP levels could contribute to the immunopathogenesis of AD and monitoring levels may be of value in the clinical evaluation of the disease.
Salpietro
D C
DC
Pediatric Therapy, Institute of Medicine Preventive and Social Pediatrics, University of Messina, Italy.
Naccari
F
F
Polimeni
I
I
Pellegrino
C
C
D002675:Child, Preschool; D000242:Cyclic AMP / Q000097:blood*; D003876:Dermatitis, Atopic / Q000097:blood* / Q000276:immunology; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D007223:Infant; D008297:Male; D011863:Radioimmunoassay
D007073:Immunoglobulin E; D000242:Cyclic AMP