title: Non-invasive estimation of human left ventricular end-diastolic pressure.
abstract: Sato et al. (Electronic Letters 32, 949-950, 1996) reported that one can obtain a non-invasive estimate of left ventricular (LV) pressure at around end-diastole in an isolated canine preparation. In this study we examined whether this method can be applied to humans. Using the method proposed by Kanai et al. (IEEE. Trans. UFFC, 43, 791-810,1996), we detected small amplitude LV vibration from an ultrasonic pulse Doppler signal reflected from the interventricular septum in five patients (44-63 y.o., male;4, female;1). We measured the oscillation frequency of the LV wall through the wavelet transform of small amplitude LV vibration, and calculated LV pressure at around end-diastole from the values of oscillation frequency, internal radius and wall thickness using Mirsky's equation. The estimated LV pressures at around end-diastole were similar to end-diastolic pressure measured directly by cardiac catheterization. These results show the possibility that this method allows for the non-invasive estimate of LV pressure at around end-diastole, and furthermore provides the basis for future clinical applicability of this technique.
authors.affiliation: The First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan. honda@sarc.phyb.uic.edu
authors.forename: H
authors.initials: H
authors.lastname: Honda
authors.forename: S
authors.initials: S
authors.lastname: Nakaya
authors.forename: H
authors.initials: H
authors.lastname: Kamada
authors.forename: H
authors.initials: H
authors.lastname: Hasegawa
authors.forename: J
authors.initials: J
authors.lastname: Demachi
authors.forename: H
authors.initials: H
authors.lastname: Chikama
authors.forename: K
authors.initials: K
authors.lastname: Sugimura
authors.forename: Y
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: N
authors.initials: N
authors.lastname: Kumasaka
authors.forename: T
authors.initials: T
authors.lastname: Takita
authors.forename: J
authors.initials: J
authors.lastname: Ikeda
authors.forename: H
authors.initials: H
authors.lastname: Kanai
authors.forename: Y
authors.initials: Y
authors.lastname: Koiwa
authors.forename: K
authors.initials: K
authors.lastname: Shirato
mesh_terms: D000328:Adult; D000818:Animals; D001698:Biomedical Engineering; D001795:Blood Pressure Determination / Q000379:methods*; D003971:Diastole; D004285:Dogs; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009991:Oscillometry; D016277:Ventricular Function, Left; D014732:Vibration