Circadian rhythm of pain in male mice.
1. Circadian rhythm of pain in response to the thermal stimuli was assessed in male mice. 2. The hot-plate method was used. Response latencies were measured every 2 hours and showed a sinusoidal rhythm. 3. Minimal latencies were observed at 10 and 20 h, the highest were obtained at 12 and 4 hours. 4. The circadian changes in pain sensitivity may play an important role in many experiments on stress and post-stress analgesia as well as on susceptibility to pharmacological agents.
Konecka
A M
AM
Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Mrokow.
Sroczynska
I
I
D000818:Animals; D002940:Circadian Rhythm; D008297:Male; D051379:Mice; D010146:Pain / Q000503:physiopathology*; D010147:Pain Measurement; D011930:Reaction Time