Ganglioside GM1 potentiates NGF action on axotomised medial septal cholinergic neurons.
Transection of the fimbria fornix leads to retrograde degeneration of axotomised septal cholinergic neurons as manifested by loss of choline acetyltransferase and p75NGFR immunoreactivity. Intracerebroventricularly administered nerve growth factor initiated at the time of axotomy can prevent these changes. We have shown that concurrent intraperitoneal administration of GM1 with a low and otherwise unprotective intracerebroventricular dose of nerve growth factor, can also prevent the loss of these fimbria fornix axotomised cholinergic neurons, where GM1 alone does not have this effect. This study further confirms the neuroprotective actions of GM1 and suggests that it may interact to potentiate the effect of nerve growth factor on these axotomised septal cholinergic neurons.
Panni
M K
MK
Medical Research Council Cambridge Centre for Brain Repair, Department of Anatomy, University of Cambridge, England, UK. mkpanni@fas.harvard.edu
Cooper
J D
JD
Sofroniew
M V
MV
D000109:Acetylcholine / Q000502:physiology*; D000818:Animals; D019771:Axotomy; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D004357:Drug Synergism; D005260:Female; D005677:G(M1) Ganglioside / Q000494:pharmacology*; D007276:Injections, Intraventricular; D009414:Nerve Growth Factors / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D020800:Receptor, Nerve Growth Factor; D017475:Receptors, Nerve Growth Factor / Q000378:metabolism; D012688:Septum Pellucidum / Q000187:drug effects* / Q000378:metabolism
D009414:Nerve Growth Factors; D018696:Neuroprotective Agents; D020800:Receptor, Nerve Growth Factor; D017475:Receptors, Nerve Growth Factor; D005677:G(M1) Ganglioside; D002795:Choline O-Acetyltransferase; D000109:Acetylcholine