title: Presentation, management and follow-up of Schilder's disease.
abstract: Schilder's diffuse myelinoclastic sclerosis is a rare demyelinating disease which often mimics intracranial neoplasm or abscess. We have treated 3 patients with this disorder in the past 5 years and followed their postoperative course. Certain distinct features of this disease will allow neurosurgeons to preoperatively entertain this diagnosis. We discuss postoperative treatment and propose a new hypothesis regarding the variable prognoses of this disorder. Schilder's disease constitutes an important diagnosis for any neurosurgeon to be aware of (especially those treating the pediatric age group) which has not received adequate coverage in the neurosurgical literature.
authors.affiliation: Division of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
authors.forename: P C
authors.initials: PC
authors.lastname: Garell
authors.forename: A H
authors.initials: AH
authors.lastname: Menezes
authors.forename: G
authors.initials: G
authors.lastname: Baumbach
authors.forename: S A
authors.initials: SA
authors.lastname: Moore
authors.forename: G
authors.initials: G
authors.lastname: Nelson
authors.forename: K
authors.initials: K
authors.lastname: Mathews
authors.forename: A K
authors.initials: AK
authors.lastname: Afifi
mesh_terms: D000293:Adolescent; D002648:Child; D002549:Diffuse Cerebral Sclerosis of Schilder / Q000175:diagnosis / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging