Effect of omeprazole on gastric bicarbonate secretion in patients with duodenal ulcer.
BACKGROUND
Omeprazole, a H+/K+ ATPase inhibitor, has been shown to reduce gastric bicarbonate secretion in cats. However, there has been no study on the effect of omeprazole on bicarbonate secretion in patients with duodenal ulcer (DU).


METHODS
Fifteen men with duodenal ulcer (mean age 38 years, range 22-57) were included. Baseline gastric acid output, bicarbonate secretion, and parietal and nonparietal secretions were estimated before and after omeprazole therapy (20 mg/day) for four weeks.


RESULTS
Omeprazole administration did not significantly alter bicarbonate secretion (3.3 [1.2] vs 2.4 [0.4] mmol/h), though there was significant reduction in gastric acidity (44.2 [6.6] vs 20.7 [4.6] mmol/L, p < 0.01).


CONCLUSIONS
Omeprazole reduces acid secretion but does not affect gastric bicarbonate secretion in patients with DU.
Singh
K
K
Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh.
Nain
C K
CK
Singh
V
V
D000328:Adult; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D001639:Bicarbonates / Q000378:metabolism*; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000627:therapeutic use*
D000897:Anti-Ulcer Agents; D001639:Bicarbonates; D009853:Omeprazole