title: Parkinson's disease selectively impairs preattentive auditory processing: an MEG study.
abstract: Auditory stimuli elicit auditory evoked magnetic fields (AEFs) called P50m and N100m, which index preconscious auditory processing in human. We investigated with a whole-head magnetometer whether Parkinson's disease (PD) impairs parallel preattentive auditory processing between the hemispheres. Stimulus blocks consisting of standard (80%) and deviant (20%) tones were monaurally presented in a passive condition to 11 PD patients with unilateral motor symptoms and to 11 age-matched healthy controls. The constant interstimulus intervals (ISIs) were 0.5 s and 2.5 s in separate blocks. The interhemispheric latency differences of the P50m and N100m were significantly lengthened in PD patients in the left-ear condition. This might be caused by the basal ganglia dysfunction in PD together with the simultaneous age-related neural degeneration predominant in the left auditory cortex.
authors.affiliation: Department of Neurology, University of Helsinki, Finland.
authors.forename: E
authors.initials: E
authors.lastname: Pekkonen
authors.forename: J
authors.initials: J
authors.lastname: Ahveninen
authors.forename: J
authors.initials: J
authors.lastname: Virtanen
authors.forename: H
authors.initials: H
authors.lastname: Teräväinen
mesh_terms: D000161:Acoustic Stimulation; D000704:Analysis of Variance; D001306:Auditory Pathways / Q000502:physiology; D001307:Auditory Perception / Q000502:physiology*; D004585:Electrooculography; D005072:Evoked Potentials, Auditory / Q000502:physiology; D007839:Functional Laterality; D006801:Humans; D015225:Magnetoencephalography; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology*; D013997:Time Factors