title: [The factors affecting the growth of the agent, producing a mild cytopathic effect, isolated in patients with epidemic neuropathy].
abstract: Certain factors influencing upon the growth of the agent producer of mild cytopathogenic effect and isolated from the cerebrospinal fluid of patients presenting with epidemic neuropathy are described in this paper. It was demonstrated that a concentration of NaHCO3 was essential for the occurrence of the cytopathogenic effect. Determined concentrations of MnCl2 allowed for the visualization of the cytopathogenic effect and increased viral yields.
authors.affiliation: Instituto de Medicina Tropical Pedro Kourí.
authors.forename: S
authors.initials: S
authors.lastname: Resik
authors.forename: M G
authors.initials: MG
authors.lastname: Guzmán
authors.forename: R
authors.initials: R
authors.lastname: Rodríguez
authors.forename: M
authors.initials: M
authors.lastname: Alvarez
authors.forename: L
authors.initials: L
authors.lastname: Morier
authors.forename: A
authors.initials: A
authors.lastname: Castillo
authors.forename: P
authors.initials: P
authors.lastname: Más
mesh_terms: D000818:Animals; D002712:Chlorides / Q000494:pharmacology; D002522:Chlorocebus aethiops; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004770:Enterovirus / Q000187:drug effects / Q000254:growth & development* / Q000302:isolation & purification / Q000472:pathogenicity; D006801:Humans; D015636:Magnesium Chloride / Q000494:pharmacology; D017895:Manganese Compounds / Q000494:pharmacology; D009902:Optic Neuritis / Q000821:virology*; D010523:Peripheral Nervous System Diseases / Q000821:virology*; D017693:Sodium Bicarbonate / Q000494:pharmacology; D013696:Temperature; D014709:Vero Cells
chemical_list: D002712:Chlorides; D017895:Manganese Compounds; D015636:Magnesium Chloride; D017693:Sodium Bicarbonate; C025340:manganese chloride