title: Sucrose rich diet modifies thermogenic response to injection of muscimol into the posterior hypothalamus in the rat.
abstract: The firing rate of the nerves innervating interscapular brown adipose tissue, temperatures of colon and interscapular brown adipose tissue, heart rate and oxygen consumption were monitored in urethane-anaesthetized male Sprague-Dawley rats fed with a sucrose rich diet. These variables were measured for 40 min before (baseline values) and 40 min after a 56 ng muscimol injection into the posterior hypothalamus. The same variables were monitored in other rats fed with a laboratory standard diet. Saline was injected into the posterior hypothalamus of control rats fed with sucrose or standard diet. Muscimol injection induced a decrease in firing rate, interscapular brown adipose tissue and colonic temperatures and oxygen consumption. This reduction was more evident in the rat fed with a sucrose rich diet than animals fed with standard diet. The kind of diet did not modify the decrease in heart rate induced by muscimol. These findings suggest that a sucrose rich diet modifies GABA-ergic responses to muscimol injection into the posterior hypothalamus.
authors.affiliation: Department of Human Physiology and Integrated Biological Functions, Second University of Naples, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Monda
authors.forename: A
authors.initials: A
authors.lastname: Sullo
authors.forename: V
authors.initials: V
authors.lastname: De Luca
authors.forename: A
authors.initials: A
authors.lastname: Viggiano
mesh_terms: D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000294:innervation / Q000502:physiology; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects* / Q000502:physiology; D003106:Colon / Q000187:drug effects; D019422:Dietary Sucrose / Q000494:pharmacology*; D018755:GABA Agonists / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D007034:Hypothalamus, Posterior / Q000502:physiology*; D007267:Injections; D008297:Male; D009118:Muscimol / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology
chemical_list: D019422:Dietary Sucrose; D018755:GABA Agonists; D009118:Muscimol