Treatment and prophylaxis of some infectious diseases of swine and cattle using of natural alpha-interferons.
On the basis of experimental studies which proved stimulating action on absorbing and bactericidal function of blood phagocytes and antibody genesis the methods of therapy and prophylaxis of wide spread infections in modern live-stock (transmissive gastroenteritis of pigs, parainfluenza of calves, colibacteriosis of swine and cattle) were created. It was established, that optimal one-time therapeutical dose of homologous alpha-IFN for intramuscular administration to new-born pigs was 2000-4000 IU per head, prophylactic dose was 1000-2000 IU. Therapeutical doses of alpha-IFN for calves did not exceed 4000-6000 IU, prophylactic--4000 IU. As a rule, it is necessary to introduce the preparation three times with 48 h intervals. With the account of these data the large-scale commissional trials of these preparations were carried out.
Kishko
Ia H
IaH
Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kyiv.
Mukvych
M S
MS
D000818:Animals; D000831:Animals, Newborn; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D000998:Antiviral Agents / Q000008:administration & dosage*; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control / Q000628:therapy*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical / Q000662:veterinary; D004927:Escherichia coli Infections / Q000517:prevention & control / Q000628:therapy / Q000662:veterinary; D005761:Gastroenteritis, Transmissible, of Swine / Q000517:prevention & control / Q000628:therapy; D016898:Interferon-alpha / Q000008:administration & dosage*; D018184:Paramyxoviridae Infections / Q000517:prevention & control / Q000628:therapy / Q000662:veterinary; D013552:Swine; D013553:Swine Diseases / Q000517:prevention & control / Q000628:therapy*
D000890:Anti-Infective Agents; D000998:Antiviral Agents; D016898:Interferon-alpha