title: Inhibitory effect of anaphylactic reaction of Sosiho-Tang.
abstract: Mast cells synthesize and secrete chemical mediators which play an central role in anaphylactic reactions. Compound 48/80 is a condensation product of formaldehyde with paramethoxyphenylethylamine that reliably induces the release of chemical mediators in the mast cell granules. Aggregation of the high-affinity Fc receptor also stimulates the mast cells. The objective of the current study was to determine the effect of Sosiho-Tang (SS-Tang) on mast cell-mediated anaphylactic reaction. SS-Tang completely inhibited systemic anaphylaxis induced by compound 48/80 in mice. SS-Tang inhibited local anaphylaxis induced by anti-dinitrophenyl (DNP) IgE. In addition SS-Tang concentration-dependently inhibited histamine release in mast cells induced by compound 48/80 or anti-DNP IgE. These results indicate that SS-Tang may contain compounds with actions that inhibit mast cell degranulation.
authors.affiliation: College of Pharmacy, Wonkwang University, Iksan, Chonbuk, South Korea.
authors.forename: H M
authors.initials: HM
authors.lastname: Kim
authors.forename: Y Y
authors.initials: YY
authors.lastname: Kim
authors.forename: H S
authors.initials: HS
authors.lastname: Moon
authors.forename: E H
authors.initials: EH
authors.lastname: Lee
authors.forename: S J
authors.initials: SJ
authors.lastname: Moon
authors.forename: N H
authors.initials: NH
authors.lastname: An
mesh_terms: D000818:Animals; D004136:Dinitrobenzenes / Q000276:immunology; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006636:Histamine Release / Q000187:drug effects; D007073:Immunoglobulin E / Q000276:immunology; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects* / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar; D003189:p-Methoxy-N-methylphenethylamine / Q000276:immunology / Q000633:toxicity
chemical_list: D004136:Dinitrobenzenes; D004365:Drugs, Chinese Herbal; D007073:Immunoglobulin E; D003189:p-Methoxy-N-methylphenethylamine