Cardioprotective properties of hydrophilic pollen extract (HPE).
Pharmacological effects of hydrophilic pollen extract (HPE) are unknown. The results of our previous studies suggest their cardioprotective influence. The purpose of the present study was to evaluate biochemical and morphological effects of HPE in adrenaline-induced myocardial damage. The study was carried out in 40 Wistar rats. Group A was intoxicated with adrenaline in a dose of 100 micrograms/kg i.p. Group A + HPE was given simultaneously HPE and adrenaline. Group K consisted of control animals. Analysis of blood enzymes and histological examination of myocardial tissue were performed 24 hours after the onset of the experiment. The activity of SGOT, CPK and AP was measured using an automatic analyzer. Whole transversal myocardial sections were obtained for histology. We evaluated cellular infiltration of the endocardium, microfocal myocyte damage, wavy myofibers, cellularity of the stroma and perivascular infiltrates. The results were compared using statistical methods. In group A the levels of SGOT and CPK were significantly higher than in groups A + HPE and K. Histological examination also revealed marked differences among these groups. The present study despite confirming cardioprotection by HPE does not provide grounds for unequivocally defining its mechanism. This problem and a possible use of HPE in cardiology require further studies.
Polański
M
M
Department of Pharmacodynamics, Jagiellonian University Medical College, Kraków.
Okoń
K
K
Przybyło
R
R
Frasik
W
W
D000135:Acid Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002316:Cardiotonic Agents / Q000494:pharmacology*; D003402:Creatine Kinase / Q000097:blood; D004837:Epinephrine; D006321:Heart / Q000187:drug effects*; D009206:Myocardium / Q000201:enzymology; D010940:Plant Proteins / Q000494:pharmacology*; D011058:Pollen / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D002316:Cardiotonic Agents; D010940:Plant Proteins; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase; D000135:Acid Phosphatase; D004837:Epinephrine