title: Agreement between predicted risk and prevalence of Down syndrome in second-trimester triple-marker screening in Japan.
abstract: Based on 9350 pregnant Japanese women who were screened by serum triple-marker determination, accuracy of predicted risk for Down syndrome was examined using 24 Down syndrome cases detected either prenatally or postnatally. The correlation is statistically very high (r = 0.98) between the predicted risks and the prevalence of Down syndrome cases. Here we emphasize that this could be accomplished only by an extensive follow-up study, implemented in our prospective intervention programme.
authors.affiliation: Jikei University School of Medicine, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Onda
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
authors.forename: O
authors.initials: O
authors.lastname: Takeda
authors.forename: M
authors.initials: M
authors.lastname: Kitagawa
authors.forename: Y
authors.initials: Y
authors.lastname: Kuwabara
authors.forename: H
authors.initials: H
authors.lastname: Yamamoto
authors.forename: K
authors.initials: K
authors.lastname: Iinuma
authors.forename: K
authors.initials: K
authors.lastname: Shimomura
mesh_terms: D000649:Amniocentesis; D015415:Biomarkers / Q000097:blood*; D004314:Down Syndrome / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007564:Japan / Q000453:epidemiology; D007621:Karyotyping; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012016:Reference Values; D012307:Risk Factors; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers