Permeability of gadolinium-DTPA through two types of hemodialysis membrane.
OBJECTIVE
Gadolinium diethylenetriamine penta-acetic acid (Gd-DTPA) was injected intravenously for magnetic resonance imaging in patients with impaired renal function, and the permeabilities of two types of general hemodialysis (HD) membrane to this agent were compared.


METHODS
One of the HD membranes, Nipro FB-210-U membrane (U membrane), has a larger pore size than the other, Nipro FB-210-M membrane (M membrane). On the same day as magnetic resonance imaging was performed, the patient underwent a 4-hour HD session. Blood was sampled before and at five points after the start of HD.


RESULTS
Mean dialysance of Gd-DTPA was 175.8 to 185.8 mL/min with the U membrane and 120.5 to 130.1 mL/min with the M membrane. The elimination rate was 91.1% with the U membrane and 81.1% with the M membrane 4 hours after the start of HD. The permeability was significantly higher with the U membrane than with the M membrane.


CONCLUSIONS
Although it is more expensive, the U membrane should be chosen rather than the M membrane for HD to remove Gd-DTPA from the body as efficiently as possible.
Ueda
J
J
Department of Radiology, Sumitomo Hospital, Osaka, Japan.
Furukawa
T
T
Yamamoto
T
T
Sakaguchi
K
K
Araki
Y
Y
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D002482:Cellulose; D003287:Contrast Media / Q000737:chemistry*; D005260:Female; D019786:Gadolinium DTPA / Q000737:chemistry*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D010539:Permeability; D006435:Renal Dialysis / Q000295:instrumentation*
D003287:Contrast Media; D008567:Membranes, Artificial; D002482:Cellulose; D019786:Gadolinium DTPA