[Vasoactive properties of various fragments of human alpha-calcitonin gene-related peptide].
Effects of some fragments of alpha-calcitonine gene-related peptide (alpha-CGRP) on the collector lymphatic vessels of the rat small intestine mesenterium, were studied. All the fragments excepting alpha-CGRP (21-24) and (21-31) activate motility of the lymphatic vessels enhancing phasic contractions of the walls. Presence of aminoacid residuals in the 20-29 area is "critical" for realising vasoactive properties by these fragments.
Akopian
V A
VA
I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Acad. Sci., St. Petersburg, Russia.
Balashov
N V
NV
Burov
S V
SV
Vlasov
G P
GP
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D066298:In Vitro Techniques; D007421:Intestine, Small / Q000187:drug effects; D008208:Lymphatic System / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008643:Mesentery / Q000187:drug effects; D010446:Peptide Fragments / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014661:Vasoconstriction / Q000187:drug effects*
D010446:Peptide Fragments; D015740:Calcitonin Gene-Related Peptide