title: The role of nm23 in melanoma progression and its prognostic significance.
abstract: The nm23 monoclonal antibody directed to specific antigen was applied for investigation of 29 benign naevi, 59 melanomas of different Clark level and locations, 4 lymph node and 28 organ metastases, using quantitative immunohistochemistry. The reduced expression of nm23 protein was associated with the tumor progression. A statistically significant difference (p = 0.0014) was found in nm23 protein expression between naevi and malignant melanomas. Additionally, a reduced protein level in metastases was found. A strong correlation was found between nm23 expression and survival of patients as well as the presence of metastasis (p = 0.0003).
authors.affiliation: Department of Cytopathology, Georg-August University, Goettingen, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Betke
authors.forename: M
authors.initials: M
authors.lastname: Korabiowska
authors.forename: U
authors.initials: U
authors.lastname: Brinck
authors.forename: H
authors.initials: H
authors.lastname: Trybus-Gałuszka
authors.forename: S
authors.initials: S
authors.lastname: Kellner
authors.forename: K
authors.initials: K
authors.lastname: Okoń
authors.forename: J
authors.initials: J
authors.lastname: Stachura
authors.forename: M
authors.initials: M
authors.lastname: Droese
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008545:Melanoma / Q000378:metabolism* / Q000473:pathology; D008875:Middle Aged; D020559:Monomeric GTP-Binding Proteins; D054778:NM23 Nucleoside Diphosphate Kinases; D009506:Nevus / Q000378:metabolism / Q000473:pathology; D009701:Nucleoside-Diphosphate Kinase; D011379:Prognosis; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D054778:NM23 Nucleoside Diphosphate Kinases; D014157:Transcription Factors; C517938:NME1 protein, human; D009701:Nucleoside-Diphosphate Kinase; D020559:Monomeric GTP-Binding Proteins