Advanced testicular germ cell tumor in a hemophilic patient with human immunodeficiency virus infection.
A stage IIIB anaplastic seminoma which occurred in an HIV-infected hemophilia is reported. The patient with hemophilia A was 36 years old and had been seropositive for HIV antibody for 3 years. Inguinal orchiectomy and subsequent chemoradiotherapy for retroperitoneal lymphadenopathy were performed and a marker negative partial response was obtained. In spite of a low initial CD4+ lymphocyte count (90/microliter), the patient tolerated the treatment well without life-threatening opportunistic infection. Although factor VIII supplement was performed, continuous bleeding from the operative wound made postoperative care difficult.
Kageyama
Y
Y
Department of Urology, Tokyo Medical and Dental University School of Medicine, Japan. kageyys.uro@med.tmd.ac.jp
Kihara
K
K
Tosaka
A
A
Nagai
H
H
Ishizaka
K
K
Tsujii
T
T
Oshima
H
H
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D000998:Antiviral Agents / Q000008:administration & dosage; D018791:CD4 Lymphocyte Count; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D016049:Didanosine / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005047:Etoposide / Q000008:administration & dosage; D005169:Factor VIII / Q000627:therapeutic use; D018237:Germinoma / Q000209:etiology* / Q000628:therapy; D006467:Hemophilia A / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male; D009919:Orchiectomy; D019258:Saquinavir / Q000008:administration & dosage; D013736:Testicular Neoplasms / Q000209:etiology* / Q000628:therapy; D015215:Zidovudine / Q000008:administration & dosage
D000998:Antiviral Agents; D015215:Zidovudine; D005047:Etoposide; D005169:Factor VIII; D016049:Didanosine; D019258:Saquinavir; D002945:Cisplatin