Plasma lipoprotein cholesterol levels in rats fed a diet enriched in cholesterol and cholic acid.
To investigate the effects of dietary cholesterol and cholic acid on plasma cholesterol levels, rats fed a cholesterol-free diet or a diet enriched in cholesterol (0.5% or 1%) with or without cholic acid supplementation were studied for 4 weeks. Although 0.5% cholesterol supplementation showed no effect on plasma total cholesterol and LDL-cholesterol levels in rats fed a diet without cholic acid treatment, the addition of dietary cholic acid caused an increase in plasma total cholesterol, LDL-cholesterol and VLDL-cholesterol levels in rats fed a cholesterol-rich diet. There was no significant change in HDL-cholesterol levels among the dietary groups. Rats fed a diet enriched in cholesterol have increased liver total lipids and total cholesterol contents. In addition, lower liver lipid peroxide concentration was found in rats fed a cholesterol-rich diet when compared with those fed the control diet. It is interesting that cholic acid supplementation led to an increase in hepatic cholesterol content and a decrease in liver lipid peroxide concentration in rats fed a cholesterol-rich diet. Results from this study suggest that dietary cholesterol and cholic acid might play an important role in regulation of lipid metabolism in rats.
Chiang
M T
MT
Department of Marine Food Science, National Taiwan Ocean University, Keelung, R.O.C.
Chen
Y C
YC
Huang
A L
AL
D000284:Administration, Oral; D000818:Animals; D002784:Cholesterol / Q000097:blood*; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D019826:Cholic Acid / Q000008:administration & dosage*; D005526:Food, Formulated; D008054:Lipid Peroxides / Q000032:analysis / Q000097:blood; D008055:Lipids / Q000032:analysis / Q000097:blood; D008074:Lipoproteins / Q000097:blood*; D008099:Liver / Q000737:chemistry; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
D002791:Cholesterol, Dietary; D008054:Lipid Peroxides; D008055:Lipids; D008074:Lipoproteins; C030104:lipoprotein cholesterol; D002784:Cholesterol; D019826:Cholic Acid