[The role of intraperitoneal chemotherapy after curative excision of primary abdominopelvic sarcoma].
Local recurrence and prognosis of abdominopelvic sarcomas depend on complete resection of the primary malignancy. Peritoneal seeding of the tumor can be assessed by the size of the tumor and the number of abdominopelvic regions involved by sarcoma. Under these conditions, we analyzed 14 consecutive patients with primary sarcoma. Complete resection of the tumor was performed in 9 patients with peritoneal involvement less than or equal to 3 abdomino-pelvic regions and complete resection combined with perioperative intraperitoneal chemotherapy was performed for the last 5 patient with involvement of more than 3 abdomino-pelvic regions. Results shows that the median survival was 28 months and the survival for very large tumors treated with perioperative intraperitoneal chemotherapy was similar to survival for smaller tumors treated by resection only. These results suggest the efficacy of chemotherapy on the site of resection and argue in favour of the use of regional chemotherapy in an attempt to achieve long-term disease-free survival for primary sarcoma.
Berthet
B
B
Département de Chirurgie Générale et Digestive, Hôpital de la Timone, Marseille.
Sugarbaker
P H
PH
D000008:Abdominal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D010478:Chemotherapy, Cancer, Regional Perfusion; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use; D018572:Disease-Free Survival; D004317:Doxorubicin / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006979:Hyperthermia, Induced; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D009366:Neoplasm Seeding; D010386:Pelvic Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D010529:Peritoneal Cavity / Q000473:pathology; D011379:Prognosis; D012509:Sarcoma / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D015996:Survival Rate; D016896:Treatment Outcome
D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D004317:Doxorubicin; D002945:Cisplatin