title: [Clinical case of the month. Hepatoportal sclerosis in a patient treated with azathioprine].
abstract: We report a case of hepatoportal sclerosis in a renal transplant patient treated with azathioprine. The initial symptom was ascites. On the biochemical level, there were cholestasis without cytolysis or hepatocellular insufficiency. A presinusoidal portal hypertension was found on haemodynamic studies, without portal thrombosis at CT-scan. A diagnosis of hepatoportal sclerosis was evoked on histology and attributed to azathioprine. This case gives an illustration of a classical albeit rare complication of azathioprine. The indolent pattern of the disease and the risk of variceal bleeding point out the need for a hepatic follow-up during the treatment.
authors.affiliation: Service de Gastro-entérologie, Université de Liège.
authors.forename: S
authors.initials: S
authors.lastname: Roland
authors.forename: J
authors.initials: J
authors.lastname: Delwaide
authors.forename: G
authors.initials: G
authors.lastname: Cornet
authors.forename: P
authors.initials: P
authors.lastname: Mahieu
authors.forename: N
authors.initials: N
authors.lastname: Jacquet
authors.forename: J
authors.initials: J
authors.lastname: Belaiche
mesh_terms: D000328:Adult; D001201:Ascites / Q000139:chemically induced; D001379:Azathioprine / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology*; D002779:Cholestasis / Q000139:chemically induced; D003937:Diagnosis, Differential; D006801:Humans; D006975:Hypertension, Portal / Q000139:chemically induced* / Q000175:diagnosis; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D008103:Liver Cirrhosis / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male
chemical_list: D007166:Immunosuppressive Agents; D001379:Azathioprine