A modified human ureter graft tanned by a new crosslinking agent polyepoxy compound for small diameter arterial substitutions: an experimental preliminary study.
The effectiveness of human ureter grafts tanned by polyepoxy compound for small diameter arterial substitution was examined in 8 carotid arteries of rabbits, followed by an observation period of either 1 month (n = 6) or 6 months (n = 2). In this model there was no evidence of rejection, aneurysm formation, or infection. The modified human ureter showed excellent patency in all cases as well as excellent function, and the histological evaluation revealed monolayer endothelial-like cells covering all of the surface of the graft as was expected. No intimal hyperplasia was demonstrated at either anastomotic site. This study suggests that our newly designed polyepoxy compound fixed human ureter could serve as a satisfactory blood conduit with good long-term patency for substitution.
Uematsu
M
M
Department of Surgery, Kobe University School of Medicine, Kobe-City, Japan.
Okada
M
M
D000714:Anastomosis, Surgical; D000783:Aneurysm / Q000209:etiology; D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D002102:Cadaver; D002339:Carotid Arteries / Q000473:pathology / Q000601:surgery*; D002340:Carotid Artery Diseases / Q000209:etiology; D003432:Cross-Linking Reagents / Q000627:therapeutic use*; D004730:Endothelium, Vascular / Q000473:pathology; D004853:Epoxy Resins / Q000627:therapeutic use*; D005260:Female; D005404:Fixatives; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000209:etiology; D006085:Graft Survival; D006801:Humans; D006965:Hyperplasia; D008297:Male; D011817:Rabbits; D013530:Surgical Wound Infection / Q000209:etiology; D014021:Tissue Preservation; D014183:Transplantation, Heterologous; D017539:Tunica Intima / Q000473:pathology; D014513:Ureter / Q000187:drug effects / Q000473:pathology / Q000637:transplantation*; D014654:Vascular Patency
D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D004853:Epoxy Resins; D005404:Fixatives; C035364:Quetol 651