title: Selective serotonin re-uptake inhibitors for the treatment of perseverative and maladaptive behaviours of people with intellectual disability.
abstract: A retrospective case-note analysis was undertaken of 37 adults with intellectual disability who lived in Leicestershire, England. The subjects were prescribed one of two selective serotonin re-uptake inhibitor (SSRI) antidepressants, i.e. fluoxetine or paroxetine, for perseverative and maladaptive behaviours. The SSRIs proved to be of no benefit for 15 subjects (40%) and led to a deterioration in a further nine cases (25%). However, some reduction of perseverative and maladaptive behaviours was achieved in 13 cases (35%). There was no difference in the responses to fluoxetine or paroxetine.
authors.affiliation: Southern Derbyshire Mental Health Trust, Derby, England.
authors.forename: D
authors.initials: D
authors.lastname: Branford
authors.forename: S
authors.initials: S
authors.lastname: Bhaumik
authors.forename: B
authors.initials: B
authors.lastname: Naik
mesh_terms: D000328:Adult; D001321:Autistic Disorder / Q000188:drug therapy / Q000523:psychology; D004359:Drug Therapy, Combination; D004739:England; D005260:Female; D005473:Fluoxetine / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008607:Intellectual Disability / Q000188:drug therapy* / Q000523:psychology; D008297:Male; D008875:Middle Aged; D017374:Paroxetine / Q000009:adverse effects / Q000627:therapeutic use*; D012189:Retrospective Studies; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D012920:Social Behavior Disorders / Q000188:drug therapy* / Q000523:psychology; D013239:Stereotyped Behavior / Q000187:drug effects*; D016896:Treatment Outcome
chemical_list: D005473:Fluoxetine; D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors