title: Inverse planning with constraints to generate smoothed intensity-modulated beams.
abstract: Highly conformal dose distributions can be generated by intensity-modulated radiotherapy. Intensity-modulated beams (IMBs) are generally determined by inverse-planning techniques designed to maximize conformality. Usually such techniques apply no constraints on the form of the IMBs which may then develop fine-scale modulation. In this paper we present a technique for generating smoother IMBs, which yields a dose distribution almost identical to that without the constraint on the form of the IMBs. The method applies various filters successively at intervals throughout the iterative inverse planning. It is shown that the IMBs so determined using a simple median window filter have desirable properties in terms of increasing the efficiency of delivery by the dynamic multileaf collimator method and may be 'more like conventional beams' than unconstrained, highly modulated IMBs.
authors.affiliation: Joint Department of Physics, Institute of Cancer Research, and Royal Marsden NHS Trust, Sutton, Surrey, UK.
authors.forename: S
authors.initials: S
authors.lastname: Webb
authors.forename: D J
authors.initials: DJ
authors.lastname: Convery
authors.forename: P M
authors.initials: PM
authors.lastname: Evans
mesh_terms: D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000532:radiotherapy; D011859:Radiography / Q000379:methods*; D011874:Radiometry