Innate and adaptive functions of the CD1 pathway of antigen presentation.
In the past few years, several studies have unravelled a novel pathway of antigen presentation to T cells of the mammalian immune system. The antigens are presented by CD1, which appears to have evolved to present glycolipid antigens to alphabeta T cells. CD1-restricted T cells are frequently autoreactive, and can promptly release key regulatory cytokines such as IL-4 and IFN-gamma. They have been implicated in a variety of autoimmune diseases including type I diabetes and lupus, in intracellular bacterial infections, and in tumor rejection. They are likely to be involved at the early, innate phase of these immune responses, providing a unique model to study the interface between the innate and adaptive immune systems.
Park
S H
SH
Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Chiu
Y H
YH
Jayawardena
J
J
Roark
J
J
Kavita
U
U
Bendelac
A
A
D000818:Animals; D017951:Antigen Presentation; D018949:Antigens, CD1 / Q000502:physiology*; D015551:Autoimmunity; D006801:Humans; D007109:Immunity; D009369:Neoplasms / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D018949:Antigens, CD1