[The postantibiotic effect of amoxicillin/clavulanic acid on Streptococcus pneumoniae strains of different serotypes and penicillin sensitivity].
Amoxicillin and clavulanic acid, combined in a 4:1 ratio, caused a significant (longer than 0.5 hours) postantibiotic effect (PAE) for the S. pneumoniae stains tested. These strains were from a different serotype (3, 6 and 9) and also had different susceptibility to penicillin. The duration of the PAE depended both on the strain and the amoxicillin/clavulanic acid concentration used. It is significant that for the serotype 9 strain, which was both penicillin and amoxicillin resistant, the duration of the PAE was between 1.5 and 2.2 hours. These results agree with those observed by other authors as to the effectiveness of amoxicillin/clavulanic acid against S.pneumoniae.
García
Y
Y
Dpto. de Microbiología, Facultad de Medicina, Universidad Complutense de Madrid.
Gómez
M J
MJ
Ramos
M C
MC
Gómez-Lus
M L
ML
Prieto
J
J
D019980:Amoxicillin-Potassium Clavulanate Combination / Q000494:pharmacology*; D016001:Confidence Intervals; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests / Q000379:methods / Q000706:statistics & numerical data; D010403:Penicillin Resistance; D010406:Penicillins / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification / Q000187:drug effects* / Q000254:growth & development
D010406:Penicillins; D019980:Amoxicillin-Potassium Clavulanate Combination