Cardiovascular effects of novel imidazoline congeners.
2-Aryl-4,5-bis(diphenyl)-1-(N-acetyl hydrazide)-1,3-imidazoline (IIb1-4) was prepared by the reaction of ethyl chloro acetate and hydrazine hydrate with 2-Aryl-4,5-bis (diphenyl)-1H-imidazoline (I a1-4), which on further substitution with aryl/heterocyclyl aldheyde gave 2-Aryl-4,5-bis (diphenyl)-1-(4-substituted hydrazone)-1,3-imidazoline (III Ca-i). This was again cyclised to oxadiazole in the presence of ferric chloride and glacial acetic acid yielded 2-Aryl-4,5-bis(diphenyl)-1-(2-substituted-1,3,4-oxadizole)-1,3-imi dazoline (IV da-i). These compounds were screened for hypotensive activity and an attempt were made to get the site of action of these compounds.
Shukla
S
S
Department of Pharmacology and Therapeutics, King George's Medical College, Lucknow, India.
Bhalla
M
M
Misra
U
U
Mukerjee
D
D
Saxsena
A K
AK
Sinha
J N
JN
Shanker
K
K
D000818:Animals; D002317:Cardiovascular Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D008297:Male
D002317:Cardiovascular Agents; D007093:Imidazoles