Heteronuclear cross polarization for enhanced sensitivity of in vivo 13C MR spectroscopy on a clinical 1.5 T MR system.
The potential of heteronuclear ¿1H-13C¿ cross polarization was studied for optimization of the signal-to-noise ratio in in vivo 13C MR spectroscopy at the clinical field strength of 1.5 T. Experiments on the human calf showed a significant chemical-shift selective signal enhancement on triglyceride signals of 3.9 by heteronuclear cross polarization, compared to a standard pulse-acquire sequence. Studies on a neonatal piglet brain showed an enhancement by cross polarization of 2.2 for the detection of 13C-1-glucose. This enhancement allowed a fourfold improvement in time resolution in dynamic 13C MR of 13C-1-glucose inflow in piglet brain. Phantom experiments demonstrated the efficiency of this technique for interleaved detection of two spectral regions. Tests with a volume coil showed the feasibility of signal enhancement by cross polarization over a large volume of interest.
van den Bergh
A J
AJ
Department of Radiology, University of Nijmegen, Nijmegen, 6500 HB, The Netherlands.
van den Boogert
H J
HJ
Heerschap
A
A
D000273:Adipose Tissue / Q000737:chemistry*; D000818:Animals; D001923:Brain Chemistry / Q000502:physiology*; D005240:Feasibility Studies; D005947:Glucose / Q000032:analysis; D005973:Glutamine / Q000032:analysis; D006801:Humans; D007089:Image Enhancement; D019344:Lactic Acid / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy; D019047:Phantoms, Imaging; D012680:Sensitivity and Specificity; D013552:Swine; D014280:Triglycerides / Q000032:analysis
D014280:Triglycerides; D005973:Glutamine; D019344:Lactic Acid; D005947:Glucose