Ultrastructural changes to the palatal mucosa of rats following the application of 4-nitroquinoline-1-oxide (4NQO) and vitamin C.
Oral mucosal neoplastic disease in rodents has been induced by various chemical carcinogens, including water soluble 4-nitroquinoline-1-oxide (4NQO). It has been suggested that vitamin C can inhibit, delay or prevent the development of neoplasms, as well as enhance the induction of neoplasia. In this investigation, 4NQO was used to produce a high yield of carcinomas of the palatal mucosa of rats in a relatively short period of time and topical vitamin C was applied to delay the neoplastic transformation. The temporal aspects of the ultrastructural changes occurring in 4NQO-induced oral palatal mucosa treated with both 4NQO and vitamin C have been described and discussed.
Kandarkar
S V
SV
Cell Biology Division, Cancer Research Institute, Tata Memorial Centre, Parel, Mumbai, India.
Sawant
S S
SS
Reade
P C
PC
D015112:4-Nitroquinoline-1-oxide / Q000494:pharmacology*; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D002273:Carcinogens / Q000494:pharmacology*; D008297:Male; D008854:Microscopy, Electron; D009061:Mouth Mucosa / Q000187:drug effects* / Q000648:ultrastructure; D010159:Palate / Q000187:drug effects* / Q000648:ultrastructure; D051381:Rats; D017207:Rats, Sprague-Dawley
D002273:Carcinogens; D015112:4-Nitroquinoline-1-oxide; D001205:Ascorbic Acid