Analysis of chromosome 6 markers in eight Utah schizophrenia pedigrees.
Eight multiplex Utah schizophrenia pedigrees were screened for linkage by applying a non-parametric linkage program, GENEHUNTER, using 30 chromosome 6 DNA markers. The overall maximum NPL score of the combined pedigrees was 1.50 (P = 0.079) at marker D6s281, located near the q terminus. The highest overall maximum NPL score for an individual pedigree was 2.81 (P = 0.043). In the chromosome 6p region, where numerous positive findings have been reported, we obtained no positive results.
Lind
B
B
Department of Psychiatry, University of Utah School of Medicine, Salt Lake City 84132, USA.
Hoff
M
M
Rosenthal
J
J
Byerley
W
W
Coon
H
H
D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D008126:Lod Score; D010375:Pedigree; D012559:Schizophrenia / Q000235:genetics*; D012984:Software
D005819:Genetic Markers