Thermoregulation in newborn lambs: influence of feeding and ambient temperature on brown adipose tissue.
We have previously shown that feeding 50 ml of colostrum can increase the thermogenic activity of brown adipose tissue (BAT) in newborn lambs maintained at a warm (30 degrees C) ambient temperature. This study further examines the effect of ambient temperature on BAT and thermoregulation by investigating the response to feeding 50 ml of water. Immediately after vaginal birth, lambs were placed in either a warm (30 degrees C) or cool (15 degrees C) environment a ambient temperature and measurements of colonic temperature and heat production were recorded for 6 h. Lambs were fed 50 ml of water when 5 h old. The level of guanosine 5'-diphosphate (GDP) binding was higher, but adrenaline content lower in BAT sampled from lambs maintained at 15 degrees C compared with those at 30 degrees C. Feeding was associated with an increase in colonic temperature and plasma concentrations of glucose and non-esterified fatty acids in lambs maintained at 15 degrees C only. In this group plasma concentrations of adrenaline and dopamine declined after feeding, but noradrenaline concentrations were not influenced by feeding in either group of lambs. O2 consumption and CO2 production were higher in lambs maintained at 15 degrees C but were not influenced by ambient temperature or feeding. It is concluded that feeding a small volume of water can influence thermoregulation by a mechanism that is dependent on the ambient temperature at which the lamb is maintained.
Clarke
L
L
Academic Division of Child Health, School of Human Development, University Hospital, Queen's Medical Centre, Nottingham, UK.
Symonds
M E
ME
D002001:Adipose Tissue, Brown / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn; D001786:Blood Glucose / Q000032:analysis; D001833:Body Temperature Regulation / Q000502:physiology*; D001835:Body Weight; D002395:Catecholamines / Q000097:blood; D003106:Colon / Q000502:physiology; D004326:Drinking / Q000502:physiology*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006153:Guanosine Diphosphate / Q000378:metabolism; D007408:Intestinal Absorption / Q000502:physiology; D008928:Mitochondria / Q000378:metabolism; D010101:Oxygen Consumption / Q000502:physiology; D011506:Proteins / Q000378:metabolism; D012756:Sheep; D013696:Temperature
D001786:Blood Glucose; D002395:Catecholamines; D005230:Fatty Acids, Nonesterified; D011506:Proteins; D006153:Guanosine Diphosphate