[Human drug metabolizing enzymes. I. Oxidative enzymes].
In this review we focus on human oxidative enzymes that are responsible for the metabolism of xenobiotics. More and more publications prove that the reactions catalysed by these enzymes very often lead to activated molecules that may attack macromolecules (proteins, RNAs, DNAs), resulting in toxicity (liver, neuro-, embryotoxicity, allergy, carcinogenecity). We have summarised the data available on these enzymes, concerning their catalytic profile and specificity, inhibition, induction properties, their possible role in the generation of toxic compounds, their importance in clinical practice and drug development.
Vereczkey
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Magyar Tudományos Akadémia, Kémiai Kutató Központ, Kémiai Intézet, Budapest.
Monostory
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Veres
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D000426:Alcohol Dehydrogenase / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D006801:Humans; D008658:Inactivation, Metabolic; D008995:Monoamine Oxidase / Q000378:metabolism; D015262:Xenobiotics / Q000493:pharmacokinetics*
D015262:Xenobiotics; D003577:Cytochrome P-450 Enzyme System; D000426:Alcohol Dehydrogenase; D008995:Monoamine Oxidase