title: Single-read sequence tags of a limited number of genomic DNA fragments provide an inexpensive tool for comparative genome analysis.
abstract: Single-read sequences from both ends of 415 3-kb average size genomic DNA fragments of Candida albicans were compared with the complete sequence data of Saccharomyces cerevisiae. Comparison at the protein level, translated DNA against protein sequences, revealed 138 sequence tags with clear similarity to S. cerevisiae proteins or open reading frames. One case of synteny was found for the open reading frames of RAD16 and LYS2, which are adjacent to each other in S. cerevisiae and C. albicans.
authors.affiliation: Hans-Knöll-Institut für Naturstoff-Forschung, Jena, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Hartung
authors.forename: D
authors.initials: D
authors.lastname: Frishman
authors.forename: A
authors.initials: A
authors.lastname: Hinnen
authors.forename: S
authors.initials: S
authors.lastname: Wölfl
mesh_terms: D000251:Adenosine Triphosphatases; D002176:Candida albicans / Q000235:genetics*; D002874:Chromosome Mapping / Q000379:methods*; D005656:Fungal Proteins; D016681:Genome, Fungal; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins; D017422:Sequence Analysis, DNA; D016324:Sequence Tagged Sites; D013045:Species Specificity
chemical_list: D005656:Fungal Proteins; D029701:Saccharomyces cerevisiae Proteins; D000251:Adenosine Triphosphatases; C075467:RAD16 protein, S cerevisiae