title: The use of silicone occlusive sheeting (Sil-K) and silicone occlusive gel (Epiderm) in the prevention of hypertrophic scar formation.
abstract: The development of hypertrophic scars and keloids is an unsolved problem in the process of wound healing. For this reason, a successful treatment to prevent excessive scar formation still has not been found. Over the last decade, however, a promising new treatment has been introduced. Silicone materials have proved to reduce the amount of scar tissue and are believed even to prevent hypertrophic scar and keloid formation. In this study, the prophylactic effect of a silicone occlusive sheeting (Sil-K, Degania, Israel) and a silicone occlusive gel (Epiderm, Inamed B.V., The Netherlands) was investigated in a bilateral breast-reduction scar model in which the nontreated scars were supported by nonocclusive Micropore (3M, The Netherlands). The inframammary scars of 129 female patients with a mean age of 31 years ( 14 to 69 years) were studied up to 1 year after the operation. The width and height were measured, and B-scan ultrasound, laser-Doppler flowmetry, and color measurements were used as objective indicators to distinguish between normal and exuberant scars. Three months following the operation, 64.3 percent of the patients developed a hypertrophic scar, which was reduced to 56.6 percent after 6 months and down to 35.3 percent after 1 year. No keloids were seen. Patients with an easily tanning skin, nonsmokers, and patients with an allergy showed more hypertrophic scar formation. Neither Sil-K, used in 68 patients, nor Epiderm, used in 61 patients, could prevent the formation of hypertrophic scars. If both groups were taken together, the scars treated with silicone materials even developed significantly more hypertrophy compared with the Micropore-applicated scars.
authors.affiliation: Department of Plastic, Reconstructive, and Hand Surgery at the University Hospital of Groningen, University of Groningen, The Netherlands.
authors.forename: F B
authors.initials: FB
authors.lastname: Niessen
authors.forename: P H
authors.initials: PH
authors.lastname: Spauwen
authors.forename: P H
authors.initials: PH
authors.lastname: Robinson
authors.forename: V
authors.initials: V
authors.lastname: Fidler
authors.forename: M
authors.initials: M
authors.lastname: Kon
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002921:Cicatrix / Q000000981:diagnostic imaging / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D005782:Gels; D006801:Humans; D006984:Hypertrophy; D007627:Keloid / Q000517:prevention & control; D017078:Laser-Doppler Flowmetry; D016462:Mammaplasty; D008875:Middle Aged; D009779:Occlusive Dressings; D011446:Prospective Studies; D012828:Silicones; D014463:Ultrasonography
chemical_list: D005782:Gels; D012828:Silicones