T-cell anergy and altered T-cell receptor signaling: effects on autoimmune disease.
Immunological self-tolerance can be acquired by several mechanisms, including the induction of anergy in autoreactive T cells. In this sense, anergy is predictably advantageous for the immune system. Here, Konstantin Salojin and colleagues present an alternative view that the induction of anergy in regulatory T cells may be harmful to the host and elicit autoimmune disease.
Salojin
K V
KV
Autoimmunity/Diabetes Group, John P. Robarts Research Institute, London, Ontario, Canada.
Zhang
J
J
Madrenas
J
J
Delovitch
T L
TL
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D017635:Clonal Anergy / Q000276:immunology*; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D016688:Mice, Inbred NOD; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D011948:Receptors, Antigen, T-Cell