title: Candidal anastomotic infection in lung transplant recipients: successful treatment with a combination of systemic and inhaled antifungal agents.
abstract: Anastomotic infection is an uncommon but potentially life-threatening complication after lung transplantation. We recently encountered three lung transplant recipients with invasive candidal anastomotic infection. Two patients were admitted with dyspnea and fever, and one asymptomatic infection was detected on surveillance bronchoscopy. All three patients were treated similarly with a combination of intravenous amphotericin B, inhaled amphotericin B, and oral fluconazole. The combination of systemic and inhaled antifungal agents successfully treated all three cases of anastomotic infection.
authors.affiliation: Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Palmer
authors.forename: J R
authors.initials: JR
authors.lastname: Perfect
authors.forename: D N
authors.initials: DN
authors.lastname: Howell
authors.forename: C M
authors.initials: CM
authors.lastname: Lawrence
authors.forename: A P
authors.initials: AP
authors.lastname: Miralles
authors.forename: R D
authors.initials: RD
authors.lastname: Davis
authors.forename: V F
authors.initials: VF
authors.lastname: Tapson
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000008:administration & dosage*; D000714:Anastomosis, Surgical; D000935:Antifungal Agents / Q000008:administration & dosage*; D001706:Biopsy; D001980:Bronchi / Q000473:pathology; D002177:Candidiasis / Q000188:drug therapy* / Q000473:pathology; D004359:Drug Therapy, Combination; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage*; D006801:Humans; D007262:Infusions, Intravenous; D016040:Lung Transplantation / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013530:Surgical Wound Infection / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B; D015725:Fluconazole