MHC-linked syngeneic developmental preference in thymic lobes colonized with bone marrow cells: a mathematical model.
Reconstitution of the T-cell compartment after bone marrow transplantation depends on successful colonization of the thymus by bone-marrow-derived progenitor cells. Recent studies compared the development of syngeneic and allogeneic bone-marrow-derived cells in co-cultures with lymphoid-depleted fetal thymus explants, leading to the discovery of MHC-linked syngeneic developmental preference (SDP) in the thymus. To determine the nature of cell interactions among the bone marrow and thymic elements that might underlie SDP, we analyzed this phenomenon by mathematical modeling. The results indicate that syngeneic mature T cells, responsible for inducing this preference, probably interfere both with the seeding of allogeneic bone-marrow-derived thymocyte progenitors in the thymic stroma and with their subsequent proliferation. In addition, the possibility of augmented death among the developing allogeneic thymocytes cannot be ruled out.
Mehr
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Dept. of Molecular Biology, Princeton University, New Jersey 08544, USA. ramit@princeton.edu
Perelson
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AS
Sharp
A
A
Segel
L
L
Globerson
A
A
D016026:Bone Marrow Transplantation / Q000276:immunology*; D008285:Major Histocompatibility Complex; D008962:Models, Theoretical; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology*; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic