title: Inhibin and ovarian cancer.
abstract: Previous observations from our laboratory have demonstrated that the levels of immunoreactive inhibin (ir-inh) are elevated in almost all patients with granulosa cell tumours and in the majority of postmenopausal women with mucinous ovarian cancers. The present manuscript confirms these findings in a larger group of postmenopausal women. Immunohistochemistry for the inhibin alpha, betaA and betaB subunits shows predominantly epithelial staining in granulosa cell tumours and in the majority of mucinous cancers. Serous cystadenocarcinomas also frequently show positive staining. Studies seeking to identify G alpha(i-2) or FSH receptor mutations have provided negative results in contrast to other reports. Further studies of the roles of the inhibin-related family of peptides in ovarian cancer diagnosis and monitoring are clearly indicated.
authors.affiliation: Prince Henry's Institute of Medical Research, Monash Medical Centre, Victoria, Australia.
authors.forename: H G
authors.initials: HG
authors.lastname: Burger
authors.forename: A
authors.initials: A
authors.lastname: Baillie
authors.forename: A E
authors.initials: AE
authors.lastname: Drummond
authors.forename: D L
authors.initials: DL
authors.lastname: Healy
authors.forename: T
authors.initials: T
authors.lastname: Jobling
authors.forename: P
authors.initials: P
authors.lastname: Mamers
authors.forename: D M
authors.initials: DM
authors.lastname: Robertson
authors.forename: B
authors.initials: B
authors.lastname: Susil
authors.forename: N
authors.initials: N
authors.lastname: Cahir
authors.forename: Y
authors.initials: Y
authors.lastname: Shen
authors.forename: K
authors.initials: K
authors.lastname: Verity
authors.forename: P J
authors.initials: PJ
authors.lastname: Fuller
authors.forename: N P
authors.initials: NP
authors.lastname: Groome
authors.forename: J K
authors.initials: JK
authors.lastname: Findlay
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D019206:GTP-Binding Protein alpha Subunits, Gi-Go / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D007265:Inhibins / Q000097:blood*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000097:blood*; D011962:Receptors, FSH / Q000032:analysis
chemical_list: D011962:Receptors, FSH; D007265:Inhibins; D019206:GTP-Binding Protein alpha Subunits, Gi-Go