[The inductive immunosuppressive activity of the lipopolysaccharide from Shigella sonnei R forms].
Investigations have been carried out to find the position of lypopolysaccharide (LPS) structural part which can be activated by the redox system and to study peculiarities of its activation. Cell-free culture filtrate (CF) of Shigella sonnei strain R colonies on the nutrient agar medium was used. It was shown that CF contained three active fractions possessing inductive immunosuppressive properties. From all the phenol-water LPS fractions only lipid A possessed activity after redox treatment. O-chain and our fractions did not express such activity. The results of our investigations have shown that inductive immunosuppressive activity of the Shigella sonnei LPS was determined by lipid A.
Borisova
E V
EV
Research Institute of Epidemiology and Infectious Diseases, Kyiv, Ukraine.
D000818:Animals; D004926:Escherichia coli / Q000472:pathogenicity; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007166:Immunosuppressive Agents / Q000302:isolation & purification / Q000494:pharmacology*; D008050:Lipid A / Q000302:isolation & purification / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D008808:Mice, Inbred CBA; D011815:R Factors; D012764:Shigella sonnei / Q000472:pathogenicity; D013329:Structure-Activity Relationship; D014774:Virulence
D007166:Immunosuppressive Agents; D008050:Lipid A; D008070:Lipopolysaccharides