title: Acute hemolytic crisis with fulminant hepatic failure as the first manifestation of Wilson's disease: a case report.
abstract: We report a 27-year-old woman who developed Coombs' negative hemolytic anemia and fulminant hepatic failure as the initial manifestation of Wilson's disease. Unmeasurably low level of serum alkaline phosphatase provided a clue to the diagnosis of Wilson's disease. The diagnosis was established with the presence of Kayser-Fleischer ring, decreased serum ceruloplasmin level, and elevated urine and serum copper levels. In spite of repeated plasmapheresis, she died of multiorgan failure on the fifth hospital day.
authors.affiliation: Department of Internal Medicine, Chonnam National University Medical School, Kwangju, Korea.
authors.forename: J J
authors.initials: JJ
authors.lastname: Lee
authors.forename: H J
authors.initials: HJ
authors.lastname: Kim
authors.forename: I J
authors.initials: IJ
authors.lastname: Chung
authors.forename: H
authors.initials: H
authors.lastname: Kook
authors.forename: J R
authors.initials: JR
authors.lastname: Byun
authors.forename: S Y
authors.initials: SY
authors.lastname: Kwon
authors.forename: M R
authors.initials: MR
authors.lastname: Park
authors.forename: K S
authors.initials: KS
authors.lastname: Choi
authors.forename: T J
authors.initials: TJ
authors.lastname: Hwang
authors.forename: D W
authors.initials: DW
authors.lastname: Ryang
mesh_terms: D000208:Acute Disease; D000328:Adult; D000743:Anemia, Hemolytic / Q000150:complications*; D003298:Coombs Test; D005260:Female; D006501:Hepatic Encephalopathy / Q000150:complications* / Q000503:physiopathology; D006527:Hepatolenticular Degeneration / Q000150:complications* / Q000503:physiopathology; D006801:Humans