title: [Disturbance of iron metabolism and sudden hearing loss: a prospective and retrospective survey].
abstract: Two hundred and eighteen patients with disorders of disturbance of iron metabolism, 215 with hematonosis and 4850 in a normal control group were studied in a prospective with sudden hearing loss and were meanwhile investigated in a retrospective review in order to evaluate the relationship between the disorders of disturbance of iron metabolism and sudden hearing loss. The findings revealed a significantly higher incidence of sudden hearing loss in the cases of disturbance of iron metabolism, than in the patients with hematonosis as well as in the normal control group. Iron deficiency and iron deficiency anemia were found in 60.84% of 429 patients with sudden hearing loss. We concluded that the risk of disturbance of iron metabolism in the cochlea will significantly increase when systemic disturbance of iron metabolism is present although the one does not necessarily indicate the other. It seems that acute disturbance of iron metabolism in cochlea causes sudden hearing loss directly or provides a pathologic basis for the disorder.
authors.affiliation: Department of Otolaryngology, Changhai Hospital, Second Military Medical University, Shanghai.
authors.forename: A
authors.initials: A
authors.lastname: Sun
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000743:Anemia, Hemolytic / Q000150:complications; D018798:Anemia, Iron-Deficiency / Q000150:complications; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D005260:Female; D003639:Hearing Loss, Sudden / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D019189:Iron Metabolism Disorders / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D011446:Prospective Studies; D012189:Retrospective Studies; D012307:Risk Factors