title: Gradient- and sensitivity-enhanced heteronuclear multiple-quantum correlation spectroscopy.
abstract: A gradient- and sensitivity-enhanced HMQC experiment has been developed. The sensitivity of the experiment is increased by factors of the square root of 2 and 2 over the conventional and gradient-enhanced HMQC experiments, respectively. This improvement is achieved by retaining both the x and the y magnetization components in the indirectly detected dimension. This experiment will be particularly useful in NMR studies of large biomolecules as the relaxation time of the multiple-quantum coherence is much longer than that of the single-quantum coherence in the slow motion limit.
authors.affiliation: Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong.
authors.forename: G
authors.initials: G
authors.lastname: Zhu
authors.forename: X
authors.initials: X
authors.lastname: Kong
authors.forename: K
authors.initials: K
authors.lastname: Sze
mesh_terms: D002147:Calmodulin / Q000737:chemistry*; D007089:Image Enhancement; D008958:Models, Molecular; D019906:Nuclear Magnetic Resonance, Biomolecular; D011485:Protein Binding; D011487:Protein Conformation; D012680:Sensitivity and Specificity
chemical_list: D002147:Calmodulin