title: Studies on Securigera securidacea (L.) Deg. et Dörfl. (Fabaceae) seeds, an antidiabetic Egyptian folk medicine.
abstract: A new cardenolide(-)-14-methoxy-rcanoside (1) was isolated from the aqueous extract of the seeds of Securigera securidacea (L.) Deg. et Dörfl. (Fabaceae) together with five new dihydrobenzofuran derivatives named securigran I-V (2-6). Kaempferol and astragalin were also isolated from the aqueous extract of the flowers. (-)-14-Methoxyhyrcanoside and the total aqueous extract of the seeds showed marked chronotropic activity. The total aqueous extract also showed a marked diuretic and severe hypokalemic effects on the K(+)-level in serum. The hypoglycemic effect of the seeds was also confirmed.
authors.affiliation: Pharmacognosy Department, Faculty of Pharmacy, Assiut University, Egypt.
authors.forename: A A
authors.initials: AA
authors.lastname: Ali
authors.forename: M H
authors.initials: MH
authors.lastname: Mohamed
authors.forename: M S
authors.initials: MS
authors.lastname: Kamel
authors.forename: M A
authors.initials: MA
authors.lastname: Fouad
authors.forename: O
authors.initials: O
authors.lastname: Spring
mesh_terms: D000818:Animals; D002240:Carbohydrate Sequence; D002851:Chromatography, High Pressure Liquid; D004232:Diuretics / Q000494:pharmacology; D004534:Egypt; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008969:Molecular Sequence Data; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D011817:Rabbits; D013055:Spectrophotometry, Infrared
chemical_list: D004232:Diuretics; D007004:Hypoglycemic Agents; D010936:Plant Extracts