title: Paracrine regulation of human placenta: control of hormonogenesis.
abstract: There is much evidence indicating that the human placenta plays a very important role in modulating the endocrinology of pregnancy. Placental tissue produces cytokines, hormones and growth factors that are essential in the regulation of the feto-maternal unit. The production of these substances is regulated by a network of interactions within and between intra-uterine through paracrine and/or autocrine mechanisms. Communication between the gestational intra-uterine tissues is critical for successful pregnancy, from the earliest stage of implantation until the expulsive phase of delivery. This is confirmed by the demonstration that the human placenta directly controls the release of substances such as hCG, hPL, steroid hormones and prostaglandins. Furthermore, there is evidence that intra-uterine tissues also can regulate ACTH release and have effects on the hypothalamus-pituitary-gonadal axis and the hypothalamus-pituitary-adrenal axis. The set of data reported in this article confirms that the placenta must be considered an organ that is essential for the initiation, maintenance and successful conclusion of pregnancy and that an imbalance between the complex network of placental regulating systems may cause serious gestational disorders.
authors.affiliation: Department of Surgical Sciences, University of Udine, Italy. felice.petreglia@DCS.uniud.it
authors.forename: F
authors.initials: F
authors.lastname: Petraglia
authors.forename: M
authors.initials: M
authors.lastname: Santuz
authors.forename: P
authors.initials: P
authors.lastname: Florio
authors.forename: T
authors.initials: T
authors.lastname: Simoncini
authors.forename: S
authors.initials: S
authors.lastname: Luisi
authors.forename: L
authors.initials: L
authors.lastname: Plaino
authors.forename: A R
authors.initials: AR
authors.lastname: Genazzani
authors.forename: A D
authors.initials: AD
authors.lastname: Genazzani
authors.forename: A
authors.initials: A
authors.lastname: Volpe
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D006063:Chorionic Gonadotropin / Q000378:metabolism; D005260:Female; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D006728:Hormones / Q000096:biosynthesis*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D010913:Pituitary-Adrenal System / Q000502:physiology; D010920:Placenta / Q000502:physiology*; D011247:Pregnancy; D011453:Prostaglandins / Q000378:metabolism
chemical_list: D006063:Chorionic Gonadotropin; D012739:Gonadal Steroid Hormones; D006728:Hormones; D011453:Prostaglandins; D000324:Adrenocorticotropic Hormone