Expression of a novel rat protein tyrosine phosphatase gene.
The cDNA sequence and expression of a novel rat protein tyrosine phosphatase (PTP) gene is reported. The predicted amino acid sequence is similar to rat PRL-1, but is more closely related to human PTP4A, another member of the recently identified fourth group of PTPs. Therefore, multiple PTPs of this group are expressed in mammalian species. The novel rat PTP gene is expressed in the anterior pituitary gland in a sexually dimorphic pattern which is indicative of a specialized role in endocrine function.
Carter
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School of Molecular and Medical Biosciences, Cardiff University, Cardiff CF1 3US, UK.
D000311:Adrenal Glands / Q000201:enzymology; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002540:Cerebral Cortex / Q000201:enzymology; D003001:Cloning, Molecular; D018076:DNA, Complementary; D006801:Humans; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008297:Male; D008969:Molecular Sequence Data; D009206:Myocardium / Q000201:enzymology; D009928:Organ Specificity; D010903:Pituitary Gland, Anterior / Q000201:enzymology; D017027:Protein Tyrosine Phosphatases / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics*; D051381:Rats / Q000235:genetics*; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000737:chemistry; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
D018076:DNA, Complementary; D011994:Recombinant Proteins; D017027:Protein Tyrosine Phosphatases