Acquired hemophilia secondary to factor VIII inhibitors after pregnancy.
We report the case of a 26 year-old woman who developed acquired hemophilia secondary to factor VIII inhibitors, two months after a normal pregnancy. The initial hemorrhagic event was a spontaneous deep muscular hematoma mimicking a deep venous thrombosis. This observation was marqued by the apparition of antibodies against porcin factor VIII under treatment by porcin factor VIII. Intravenous immunoglobulin was ineffective, then cyclophosphamide was necessary to control the disease.
Dhôte
R
R
Service de Médecine Interne, Hôpital Cochin, Paris.
Stieltjes
N
N
Thevenot
T
T
Permal
S
S
Pernin
N
N
Molho
P
P
Christoforov
B
B
D000074:Acenocoumarol / Q000008:administration & dosage / Q000009:adverse effects*; D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects*; D001780:Blood Coagulation Tests; D003937:Diagnosis, Differential; D005169:Factor VIII / Q000037:antagonists & inhibitors*; D005260:Female; D006467:Hemophilia A / Q000097:blood / Q000139:chemically induced*; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D011247:Pregnancy; D011644:Puerperal Disorders / Q000097:blood / Q000139:chemically induced*; D012008:Recurrence
D000925:Anticoagulants; D005169:Factor VIII; D006493:Heparin; D000074:Acenocoumarol