title: Langerhans cell histiocytosis localized to the eyelid.
abstract: We treated a 46-year-old Japanese man with Langerhans cell histiocytosis (LCH) localized to the eyelid alone. He was cured successfully by local and complete resection. Results of pathological examinations of the excised tumor demonstrated diffuse infiltration by atypical histiocytic cells with eosinophilic cytoplasm and convoluted nuclei, S100 immunoreactivity, and tennis-racket-shaped Birbeck granules. Based on these pathological findings, we diagnosed LCH. Clinical examination revealed no LCH involvement in other parts of the body. To our knowledge, there has been only one report of LCH occurring as an isolated tumor in the eyelid. Generally LCH has been reported in children or young people. This is an unusual case of LCH isolated to the eyelid of an older patient.
authors.affiliation: Department of Ophthalmology, Yamaguchi University School of Medicine, Ube, Japan. chikama@po.cc.yamaguchi-u.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Chikama
authors.forename: H
authors.initials: H
authors.lastname: Yoshino
authors.forename: T
authors.initials: T
authors.lastname: Nishida
authors.forename: T
authors.initials: T
authors.lastname: Nagasawa
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Iwata
mesh_terms: D005141:Eyelid Diseases / Q000473:pathology* / Q000601:surgery; D006644:Histiocytes / Q000737:chemistry / Q000648:ultrastructure; D006646:Histiocytosis, Langerhans-Cell / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009418:S100 Proteins / Q000032:analysis
chemical_list: D009418:S100 Proteins