title: [Anti-tumor effects of ailing-1 on human megakaryoblastic leukemia cells].
abstract: OBJECTIVE
  To evaluate the anti-cancer effect of Ailing-1 on human megakaryoblastic leukemia cells in culture.
  
  
  METHODS
  Using living cell counting, 3H-TdR incorporation and clonal proliferation assay.
  
  
  RESULTS
  Ailing-1 has various cytotoxicity on cell level, DNA synthesis and clone proliferation and shows good does-effect relation. The ED50 of Ailing-1 is greater than that of homoharringtonine through three different methods, consistent with the clinical result. Drug resistance has not been found.
  
  
  CONCLUSIONS
  Ailing-1 is a promising anti-tumor drug.
authors.affiliation: Second Hospital of Tianjin Medical University.
authors.forename: X M
authors.initials: XM
authors.lastname: Duan
authors.forename: J S
authors.initials: JS
authors.lastname: Xu
authors.forename: X M
authors.initials: XM
authors.lastname: Xin
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006248:Harringtonines / Q000494:pharmacology; D000077863:Homoharringtonine; D006801:Humans; D007947:Leukemia, Megakaryoblastic, Acute / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004273:DNA, Neoplasm; D004365:Drugs, Chinese Herbal; D006248:Harringtonines; D000077863:Homoharringtonine