title: Colony stimulating factor-inducing activity of isoflavone C-glucosides from the bark of Dalbergia monetaria.
abstract: To obtain immunomodulating substances from Amazonian medicinal plants, hot water extracts from 21 samples available commercially were tested in terms of mitogenic and colony-stimulating factor (CSF)-inducing activities. Among them, Dalbergia monetaria exhibited the highest CSF-inducing activity. Orobol 8-C-glucoside (OCG-8) and orobol 6-C-glucoside (OCG-6) were isolated from the bark of D. monetaria as major constituents. The CSF-inducing activity of OCG-8 was higher than that of OCG-6 and a dose-dependent manner at a range of 0.1-10 mg/mouse. Serum CSF production induced by an intraperitoneal (i.p.) injection with 1 mg OCG-8 reached a peak at 4-6 h later, suggesting that OCG-8 would act on hematopoietic system.
authors.forename: K
authors.initials: K
authors.lastname: Kawaguchi
authors.forename: S de M
authors.initials: Sde M
authors.lastname: Alves
authors.forename: T
authors.initials: T
authors.lastname: Watanabe
authors.forename: S
authors.initials: S
authors.lastname: Kikuchi
authors.forename: M
authors.initials: M
authors.lastname: Satake
authors.forename: Y
authors.initials: Y
authors.lastname: Kumazawa
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D003115:Colony-Stimulating Factors / Q000096:biosynthesis* / Q000097:blood; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007529:Isoflavones / Q000737:chemistry; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000276:Adjuvants, Immunologic; D003115:Colony-Stimulating Factors; D005960:Glucosides; D007529:Isoflavones