Familial brain wave patterns: study of a 12-sib family.
In the sense of a paradigm for the heritability of complex psychiatric disorders, we compared the brain wave patterns of a 12-sib family with those of 144 unrelated controls and with those of 14 pairs of monozygotic twins. Under constant experimental conditions, electroencephalogram (EEG) parameters generally displayed a broad range of inter-individual differences, but were also remarkably stable over time within each subject, thus suggesting that the variation of EEG parameters forms a continuous phenotypic range rather than discrete phenotype classes. The distributions of all EEG parameters were found to be unimodal but significantly different from a normal distribution. Although an unimodal distribution speaks in favor of a polygenic additive mode of inheritance, this may not necessarily be true. Our findings might reflect the fact that a symmetric environmental distribution is converted through the underlying genotypes' norm of reaction into an asymmetric phenotype distribution. On the other hand, the distributions of the power-related EEG parameters were not that clearly unimodal, and with a larger sample size a trimodal solution might have become significant. With respect to the between-sib EEG similarity, we found the empirically derived value to be approximately half that of the within-subject similarity at 14-day intervals and of the within-pair similarity of monozygotic twins. This finding confirmed earlier results on monozygotic twins brought up together and reared apart, concerning the estimated value of h2. All in all, the EEG paradigm has clearly demonstrated that the methods of quantitative genetics represent a powerful tool once phenotypes designed to assess the variation of a trait are based on dimensional quantities.
Stassen
H H
HH
Psychiatric University Hospital, Research Department, Zurich, Switzerland. k454910@bli.unizh.ch
Bomben
G
G
Hell
D
D
D000200:Action Potentials / Q000235:genetics*; D000328:Adult; D000367:Age Factors; D001921:Brain / Q000502:physiology*; D004569:Electroencephalography; D005260:Female; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009679:Nuclear Family; D010641:Phenotype; D012016:Reference Values; D015203:Reproducibility of Results; D012737:Sex Factors; D014430:Twins, Monozygotic / Q000235:genetics