title: Factor V Leiden mutation is not increased in patients with inflammatory bowel disease.
abstract: Individuals with inflammatory bowel disease (IBD) are known to have an increased incidence of thromboembolic disease. Activated protein C resistance (APCR) has been identified as one of several inherited disorders of coagulation that predispose individuals to thromboembolic problems. This resistance results from a single point mutation in the factor V gene, called factor V Leiden. It has been suggested that many patients with IBD have APCR, as tested by a clotting assay. We have evaluated a series of 49 patients with IBD, none of whom had a history of thromboembolic disease. We assayed for the factor V Leiden mutation by polymerase chain reaction and found only one heterozygote. Seventeen of the 49 patients were negative for APCR by the clotting assay. Factor V Leiden mutation is not more common in patients with IBD than in the general population. We were unable to confirm a prior report indicating that patients with IBD have a higher prevalence of resistance to activated protein C.
authors.affiliation: Department of Medicine, Saint Barnabas Medical Center, Livingston, New Jersey, USA.
authors.forename: N P
authors.initials: NP
authors.lastname: Zauber
authors.forename: M
authors.initials: M
authors.lastname: Sabbath-Solitare
authors.forename: G
authors.initials: G
authors.lastname: Rajoria
authors.forename: G
authors.initials: G
authors.lastname: Mogan
mesh_terms: D020016:Activated Protein C Resistance / Q000235:genetics; D000293:Adolescent; D000328:Adult; D000368:Aged; D003093:Colitis, Ulcerative / Q000235:genetics*; D003424:Crohn Disease / Q000235:genetics*; D005165:Factor V / Q000235:genetics*; D005260:Female; D006580:Genetic Carrier Screening; D006801:Humans; D008297:Male; D008875:Middle Aged; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D013923:Thromboembolism / Q000235:genetics
chemical_list: C095381:factor V Leiden; D005165:Factor V