title: Neuromuscular responses to pyridostigmine bromide in organotypic spinal cord-muscle culture.
abstract: Pyridostigmine bromide (PB) promotes and then silences cholinergic muscle activity, and disrupts the junctional regions of muscle fibers and associated nerve terminals, in organotypic mouse spinal cord-muscle cultures continuously treated with low concentrations of the drug for up to 14 days. Spontaneous muscle activity is restored within 1 week of drug removal.
authors.affiliation: Department of Veterans, Affairs Medical Center, Portland, Oregon, USA.
authors.forename: R
authors.initials: R
authors.lastname: Drake-Baumann
authors.forename: F J
authors.initials: FJ
authors.lastname: Seil
authors.forename: P S
authors.initials: PS
authors.lastname: Spencer
mesh_terms: D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D051379:Mice; D009469:Neuromuscular Junction / Q000187:drug effects*; D009498:Neurotoxins / Q000494:pharmacology*; D009924:Organ Culture Techniques; D011729:Pyridostigmine Bromide / Q000494:pharmacology*; D013116:Spinal Cord / Q000187:drug effects*
chemical_list: D002800:Cholinesterase Inhibitors; D009498:Neurotoxins; D011729:Pyridostigmine Bromide