title: L1 makes immunological progress by expanding its relations.
abstract: The cell-adhesion molecule L1 was originally described in the nervous system. It has recently been detected in CD4+ T lymphocytes, peripheral B lymphocytes, and granulocytes in the human immune system and in similar leucocyte types in the murine immune system. L1 mediates neural recognition by Ca+2, Mg+2-independent homophilic binding. In the human and murine immune systems, L1 binds to the "classical" vitronectin receptor, alphaVbeta3, and fibronectin receptor, alpha5beta1, respectively, and abstains from homophilic binding. Homophilic L1 binding probably involves antiparallel alignment of several interactive domains. Integrin binding is mediated by a short segment of immunoglobulinlike domain 6, which includes two RGD repeats in rodent L1 and one RGD motif in human L1. L1 is modulated in activated leucocytes in vitro in parallel to L-selectin, and diverse cell types release intact L1 in vivo and in vitro. Released L1 can bind to laminin and adheres to the extracellular matrix of sciatic nerve, M21 melanoma, and possibly spleen and other tissues. It can support integrin-dependent cell migration and preliminary data implicate it in tumor development and transnodal lymphocyte migration.
authors.affiliation: Department of Cellular Immunology, German Cancer Research Centre, Heidelberg.
authors.forename: G
authors.initials: G
authors.lastname: Kadmon
authors.forename: A M
authors.initials: AM
authors.lastname: Montgomery
authors.forename: P
authors.initials: P
authors.lastname: Altevogt
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002240:Carbohydrate Sequence; D002448:Cell Adhesion / Q000502:physiology; D002465:Cell Movement; D006801:Humans; D016023:Integrins / Q000378:metabolism; D039841:Leukocyte L1 Antigen Complex; D008214:Lymphocytes / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000276:immunology* / Q000378:metabolism; D008969:Molecular Sequence Data; D019006:Neural Cell Adhesion Molecules / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D016023:Integrins; D039841:Leukocyte L1 Antigen Complex; D008562:Membrane Glycoproteins; D019006:Neural Cell Adhesion Molecules