title: The biogenesis and properties of the parasitophorous vacuoles that harbour Leishmania in murine macrophages.
abstract: Leishmania are protozoan parasites that, as amastigotes, live in the macrophages of mammalian hosts within compartments called parasitophorous vacuoles. These organelles share features with late endosomes/lysosomes and are also involved in the trafficking of several major histocompatibility complex (MHC)-encoded molecules. Improved knowledge of the parasitophorous vacuoles may help clarify how these protozoa persist in their hosts.
authors.affiliation: Dépt de Physiopathologie, Institut Pasteur, Paris, France. jantoine@pasteur.fr
authors.forename: J C
authors.initials: JC
authors.lastname: Antoine
authors.forename: E
authors.initials: E
authors.lastname: Prina
authors.forename: T
authors.initials: T
authors.lastname: Lang
authors.forename: N
authors.initials: N
authors.lastname: Courret
mesh_terms: D000220:Adaptation, Biological; D000818:Animals; D004705:Endocytosis; D006790:Host-Parasite Interactions; D007425:Intracellular Membranes / Q000737:chemistry; D007891:Leishmania / Q000276:immunology*; D007896:Leishmaniasis / Q000469:parasitology*; D008264:Macrophages / Q000469:parasitology*; D008285:Major Histocompatibility Complex; D051379:Mice; D018448:Models, Immunological; D010588:Phagosomes / Q000469:parasitology*; D014617:Vacuoles / Q000469:parasitology*