Mutation involving cytochrome P450IID6 in two Japanese patients with neuroleptic malignant syndrome.
Cytochrome P450IID6 (CYP2D6) plays an important role in the hepatic metabolism of various psychotropic drugs. We detected a mutation of the CYP2D6 gene in two patients who previously had episodes of neuroleptic malignant syndrome (NMS). They were homozygous for a mutated CYP2D6J allele conferring a poor-metabolizer phenotype. Possession of this trait may contribute to susceptibility to NMS.
Kawanishi
C
C
Department of Psychiatry, Yokohama City University School of Medicine, Yokohama, Japan.
Shimoda
Y
Y
Fujimaki
J
J
Onishi
H
H
Suzuki
K
K
Hanihara
T
T
Sugiyama
N
N
Kosaka
K
K
D000483:Alleles; D019943:Amino Acid Substitution; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000493:pharmacokinetics; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics* / Q000502:physiology; D004252:DNA Mutational Analysis; D020022:Genetic Predisposition to Disease; D006720:Homozygote; D006801:Humans; D008658:Inactivation, Metabolic / Q000235:genetics; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D008875:Middle Aged; D009459:Neuroleptic Malignant Syndrome / Q000201:enzymology / Q000235:genetics*; D017354:Point Mutation
D014150:Antipsychotic Agents; D019389:Cytochrome P-450 CYP2D6