[The clinico-immunological parallels of hemosorption using different sorbents in the treatment of bronchial asthma patients].
A comprehensive clinical and functional and allergo-immunological comparative evaluation was done of hemosorption involving the KAU, SKN hemosorbents, "Gemosfer" and a DNA-containing sorbent in 341 patient with bronchial asthma. SKN sorbent were found out to have a more pronounced positive effect on clinical signs and functional activity of immunocompetent cells. The above sorbents appeared to significantly enhance sensitivity of bronchial beta-adrenoreceptors; besides, they allow the dosages of systemic corticosteroids to be substantially brought down. The KAU and "Gemosfer" hemosorbents caused, to a certain degree, a blockade of the phagocyte system of blood, and, to a considerably lesser extent, affected the level of autoimmune processes. Thus, hemosorption should involve SKN sorbents or an SKN-based DNA-containing sorbent.
Tkachenko
Iu Ia
IuIa
D000280:Administration, Inhalation; D000328:Adult; D001249:Asthma / Q000276:immunology / Q000503:physiopathology / Q000628:therapy*; D015551:Autoimmunity; D001993:Bronchodilator Agents / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005069:Evaluation Studies as Topic; D006464:Hemoperfusion / Q000379:methods*; D006801:Humans; D007111:Immunity, Cellular; D008875:Middle Aged; D012119:Respiration; D013997:Time Factors
D001993:Bronchodilator Agents