title: Martefragin A, a novel indole alkaloid isolated from red alga, inhibits lipid peroxidation.
abstract: Martefragin A (1), a novel indole alkaloid, was isolated from a red alga, Martensia fragilis, by repeated column chromatography. The structure of 1 was elucidated on the basis of spectral analysis of its methyl ester (2), including 1H- and 13C-NMR, 1H-1H correlation spectroscopy (COSY), and 13C-1H COSY. A single crystal X-ray analysis of the hydrochloride of 1 confirmed the assignment. Martefragin A (1) showed inhibitory activity on NADPH-dependent lipid peroxidation in rat liver microsomes. The IC50 values of 1, alpha-tocopherol and ascorbic acid were 2.8, 87 and 200 microM, respectively.
authors.affiliation: Toyama Prefectural Institute for Pharmaceutical Research, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Matsunaga
authors.forename: C
authors.initials: C
authors.lastname: Hasegawa
authors.forename: H
authors.initials: H
authors.lastname: Saito
authors.forename: D
authors.initials: D
authors.lastname: Fujita
authors.forename: F
authors.initials: F
authors.lastname: Kiuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Tsuda
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008745:Methylation; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D009251:NADPH-Ferrihemoprotein Reductase / Q000037:antagonists & inhibitors; D051381:Rats; D017208:Rats, Wistar; D000461:Rhodophyta / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D000975:Antioxidants; D007211:Indoles; C115837:Martefragin A; D009251:NADPH-Ferrihemoprotein Reductase