[Dynamics of immunologic indicators in guinea pigs upon administering various preparations of the Ebola virus].
Immunological and hematological values are analyzed in guinea pigs infected with Ebola virus (EV) strain weakly pathogenic for these animals, inactivated EV, and EV strain adapted to guinea pigs and causing a lethal infection in them. The disease induced by lethal EV differed from that induced by other EV strains. Blastic wave in lymphoid organs in the absence of antibodies to EV detected by enzyme immunoassay, elimination of circulating immune complexes, and appearance of eosinophils in the blood of guinea pigs infected with lethal EV suggest the formation of aggressive immune complexes actively precipitating in tissues and contributing to the development of pathological process typical of Ebola infection.
Dadaeva
A A
AA
Sizikova
L P
LP
Zhukov
V A
VA
Chepurnov
A A
AA
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000936:Antigen-Antibody Complex / Q000097:blood; D029043:Ebolavirus / Q000276:immunology*; D006168:Guinea Pigs; D019142:Hemorrhagic Fever, Ebola / Q000097:blood / Q000276:immunology* / Q000473:pathology; D014765:Viral Vaccines / Q000008:administration & dosage*
D000914:Antibodies, Viral; D000936:Antigen-Antibody Complex; D014765:Viral Vaccines