title: A database of experimental results on globin gene expression.
abstract: Information on gene expression and regulation is expanding rapidly, and the complexity of the experimental design and data makes unique demands on databases to store the results. We describe a prototype database containing experimental results on the expression of mammalian beta-like globin genes, along with several query methods for accessing the information. The database has tables for DNA transfer experiments, protein-DNA binding results, and positions of DNase hypersensitive sites, which make extensive use of nested data structures. Comparison of data from various mammals is accomplished by providing a common coordinate system via a simultaneous alignment of matching DNA sequences. Interactive access to the database is available at a site called the Globin Gene Server on the World Wide Web (http://globin.cse. psu.edu). This software should be useful for any genetic system in which DNA sequence data are available.
authors.affiliation: The Center for Gene Regulation, The Pennsylvania State University, University Park, Pennsylvania, 16802, USA.
authors.forename: C
authors.initials: C
authors.lastname: Riemer
authors.forename: A
authors.initials: A
authors.lastname: ElSherbini
authors.forename: N
authors.initials: N
authors.lastname: Stojanovic
authors.forename: S
authors.initials: S
authors.lastname: Schwartz
authors.forename: P B
authors.initials: PB
authors.lastname: Kwitkin
authors.forename: W
authors.initials: W
authors.lastname: Miller
authors.forename: R
authors.initials: R
authors.lastname: Hardison
mesh_terms: D000818:Animals; D001665:Binding Sites / Q000235:genetics; D004247:DNA / Q000235:genetics; D016208:Databases, Factual; D003851:Deoxyribonucleases; D015870:Gene Expression; D005914:Globins / Q000235:genetics*; D006801:Humans; D020407:Internet; D019901:Locus Control Region; D011485:Protein Binding; D012984:Software
chemical_list: D005914:Globins; D004247:DNA; D003851:Deoxyribonucleases