Early post-radiation changes of red blood cell shape in rats.
Scanning electron microscopy (SEM) of red blood cells in whole blood samples from rats was performed following acute gamma-irradiation of animals with 0.25 to 1 Gy. Increased incidence of echinocytosis was observed and found to be dose- and time-dependent. At a higher radiation dose (1 Gy), echinocytosis was revealed within 5 minutes after treatment and persisted up to 3 weeks. The data demonstrate the applicability of SEM for detecting minimal radiation-induced lesions of red blood cells.
Zharskaya
V D
VD
Primorsky Health Rehabilitation Center, St. Petersburg, Russia. vna@camt.spb.su
Chukhlovin
A B
AB
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D004912:Erythrocytes / Q000528:radiation effects* / Q000648:ultrastructure; D005720:Gamma Rays; D008855:Microscopy, Electron, Scanning; D051381:Rats; D017208:Rats, Wistar