[Clinical single case study (n-of-1 trial)].
We conducted a single case (N-of-1) randomized trial in two patients. In the first case with bronchiolitis obliterans after lung transplantation a beneficial effect of inhaled steroids could be documented. The second patient suffered from symptoms compatible with HIV-associated M. Addison improving after cortisone, but the adrenocortical function was normal. Because the patient required the cortison treatment to be continued, we performed a n-of-1 trial which demonstrated the inefficacy of cortisone. This experience underscores the feasibility and usefulness of N-of-1 randomized clinical trials in medical practice.
Speich
R
R
Departement Innere Medizin, Universitätsspital Zürich.
D000224:Addison Disease / Q000188:drug therapy; D000280:Administration, Inhalation; D000328:Adult; D000730:Androstadienes / Q000008:administration & dosage; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage; D001989:Bronchiolitis Obliterans / Q000188:drug therapy; D003348:Cortisone / Q000008:administration & dosage; D004311:Double-Blind Method; D005260:Female; D000068298:Fluticasone; D006084:Graft Rejection / Q000188:drug therapy; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy; D016032:Randomized Controlled Trials as Topic / Q000706:statistics & numerical data*; D016896:Treatment Outcome
D000730:Androstadienes; D018927:Anti-Asthmatic Agents; D000068298:Fluticasone; D003348:Cortisone