Role of neurotrophic factors in motoneuron development.
More than 10 factors from different gene families are now known to enhance motoneuron survival, and to be expressed in a manner consistent with a role in regulating motoneuron numbers during development. We provide evidence that: a) different factors may act on different sub-populations of motoneurons; b) different factors may act in synergy on a given motoneuron. Thus, the functional diversity of motoneurons, and the cellular complexity of their environment, may be reflected in the mechanisms that have evolved to keep them alive.
Henderson
C E
CE
INSERM U382, IBDM (CNRS-INSERM-Univ. Méditerranée-AP Marseille), France.
Yamamoto
Y
Y
Livet
J
J
Arce
V
V
Garces
A
A
deLapeyrière
O
O
D000818:Animals; D002470:Cell Survival / Q000502:physiology; D009046:Motor Neurons / Q000502:physiology*; D005810:Multigene Family; D009414:Nerve Growth Factors / Q000235:genetics / Q000502:physiology*
D009414:Nerve Growth Factors