title: Homozygous deletions at 3p12 in breast and lung cancer.
abstract: We have constructed a physical map of the region homozygously deleted in the U2020 cell line at 3p12, including the location of putative CpG islands. Adjacent to one of these islands, we have identified and cloned a new gene (DUTT1) and used probes from this gene to detect two other homozygous deletions occurring in lung and breast carcinomas: the smallest deletion is within the gene itself and would result in a truncated protein. The DUTT1 gene is a member of the neural cell adhesion molecule family, although its widespread expression suggests it plays a less specialized role compared to other members of the family.
authors.affiliation: Medical Research Council Centre, Macclesfield, Cheshire, UK.
authors.forename: V
authors.initials: V
authors.lastname: Sundaresan
authors.forename: G
authors.initials: G
authors.lastname: Chung
authors.forename: A
authors.initials: A
authors.lastname: Heppell-Parton
authors.forename: J
authors.initials: J
authors.lastname: Xiong
authors.forename: C
authors.initials: C
authors.lastname: Grundy
authors.forename: I
authors.initials: I
authors.lastname: Roberts
authors.forename: L
authors.initials: L
authors.lastname: James
authors.forename: A
authors.initials: A
authors.lastname: Cahn
authors.forename: A
authors.initials: A
authors.lastname: Bench
authors.forename: J
authors.initials: J
authors.lastname: Douglas
authors.forename: J
authors.initials: J
authors.lastname: Minna
authors.forename: Y
authors.initials: Y
authors.lastname: Sekido
authors.forename: M
authors.initials: M
authors.lastname: Lerman
authors.forename: F
authors.initials: F
authors.lastname: Latif
authors.forename: J
authors.initials: J
authors.lastname: Bergh
authors.forename: H
authors.initials: H
authors.lastname: Li
authors.forename: N
authors.initials: N
authors.lastname: Lowe
authors.forename: D
authors.initials: D
authors.lastname: Ogilvie
authors.forename: P
authors.initials: P
authors.lastname: Rabbitts
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3; D005260:Female; D006720:Homozygote; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*