title: [Housing conditions and allergic sensitization in children].
abstract: Genetic predisposition and indoor exposure to allergens-especially during the very early childhood years are major factors for the development of allergic diseases later in life. The present study analyzed the association between allergic sensitization in children aged 5 to 14 years and residing since birth in homes of different building types. A cross-sectional study of 811 children aged 5 to 14 years who resided in the same home since birth investigated indoor factors using a questionnaire and allergic sensitization assessed by skin prick test. The prevalence of allergic sensitization was compared between children who lived since birth in five different building types. After adjustment for age, gender, parental education and study area the odds of allergic sensitization were higher among children who lived in prefabricated concrete slab buildings built after 1970 (OR 1.56, 95% CI: 1.02-2.38) and among children who lived in new brick buildings (OR 1.75, 95% CI: 0.88-3.47) than among children who lived in old brick buildings. Moreover, the odds of pollen sensitization was higher among children who lived in the new building types (prefabricated slab buildings: OR 1.68, 95% CI: 1.04-2.72; new brick buildings: OR 1.48, 95% CI: 0.64-3.42) while living in timber-framed houses was associated with a higher odds of sensitization against mites (OR 1.63, 95% CI: 0.77-3.44). The step by step inclusion of single indoor factors like type of heating, numbers of building storeys, number of persons per room, environmental tobacco smoke, use of gas for cooking purposes, dampness of the home or visible moulds in the logistic regression model only marginally changed the odds ratios. Modern living conditions are associated with a higher odds of allergic sensitization.
authors.affiliation: GSF-Forschungszentrum für Umwelt und Gesundheit, Institut für Epidemiologie, Neuherberg. Joachim.Heinrich@gsf.de
authors.forename: J
authors.initials: J
authors.lastname: Heinrich
authors.forename: B
authors.initials: B
authors.lastname: Hölscher
authors.forename: M
authors.initials: M
authors.lastname: Wjst
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000485:Allergens; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004522:Educational Status; D005260:Female; D005858:Germany / Q000453:epidemiology; D006798:Housing; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D010290:Parents; D015995:Prevalence; D012882:Skin Tests; D011795:Surveys and Questionnaires
chemical_list: D000485:Allergens