Fatal chloroquine intoxication.
A suicidal ingestion of an unknown quantity of Resochin (chloroquine) tablets is described. Although chloroquine is known since 1934, intoxications due to chloroquine overdose are rather rare in European countries. The authors report on a new and fast method of analysing and determining the chloroquine concentration in body fluids and postmortem specimens. The analytes were extracted from alkalinized samples into ethyl acetate before GC/MS analysis. The analyses of chloroquine were performed without any complex sample clean-up steps and, in addition, with little sample material. The proposed method resulted in a rapid procedure most useful in cases of deliberate poisoning with the anti-inflammatory and antimalarial drug chloroquine.
Keller
T
T
Institute of Forensic Medicine, Paris-Lodron-University, Salzburg, Austria.
Schneider
A
A
Lamprecht
R
R
Aderjan
R
R
Tutsch-Bauer
E
E
Kisser
W
W
D000328:Adult; D000962:Antimalarials / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning*; D002738:Chloroquine / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning; D017809:Fatal Outcome; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D013405:Suicide; D014018:Tissue Distribution
D000962:Antimalarials; C023676:chloroquine diphosphate; D002738:Chloroquine