[The effect of immunogenetic factors on the development of cerebral palsy and the selection of patients for effective rehabilitation].
The results obtained in 1000 patients with infantile cerebral paralysis (of these, 114 children had an immunogenetic screening conducted in them) showed the basic causes underlying the above condition's pathogenesis to be incomplete pregnancy, suspended prior pregnancy, intrauterine hypoxia of different geneses; familial and immunogenetic predisposition presenting as a pathological influence of HLA antigens-aggressors (B5, B7, B12) with low occurrence of antigens-protectors (A11, B18, B22, B40) in association with psychoneurological dysfunctions (detected in parents) manifested by psycho-speech/language disorders as well as by disturbances in motor performance. The clinical and immunogenetic-instrumental screening conducted in a timely fashion in the risk group can become an objective diagnostic aid for early recognition of cerebral paralysis, prognostication of the course it runs, and can also be used in both early and subsequent multistaged medical and social rehabilitation projects.
Ievtushenko
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D000293:Adolescent; D002547:Cerebral Palsy / Q000209:etiology* / Q000235:genetics / Q000276:immunology / Q000534:rehabilitation*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006680:HLA Antigens / Q000097:blood; D006801:Humans; D007125:Immunogenetics; D007223:Infant; D007621:Karyotyping; D008297:Male; D018579:Patient Selection; D012189:Retrospective Studies
D006680:HLA Antigens