Boy with an interstitial 1q (q31q41) duplication confirmed by fluorescent in situ hybridisation.
A 20-year-old man with multiple anomalies caused by a de novo duplication of the long arm of chromosome 1 is presented. The patient suffers from severe mental retardation, epilepsy, bronchial stenosis, and minor anomalies (e.g., hirsutism, midface dysplasia, and beaked nose). A G-banding analysis of the patient's chromosomes showed additional segments in chromosome 1. Fluorescent in situ hybridisation analysis with a chromosome 1 painting probe showed that the extra material originated from chromosome 1. Further analysis with cosmid probes demonstrated that the region involving chromosome bands 1q31 to q41 is present in a tandem duplication.
Sillén
A
A
Department of Clinical Genetics, Uppsala University Children's Hospital, Sweden.
Wadelius
C
C
Annerén
G
G
D000015:Abnormalities, Multiple / Q000235:genetics*; D000328:Adult; D002460:Cell Line; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D002878:Chromosomes, Human, Pair 1; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male