Reversing effects of DDPH on cardiac hypertrophy and increased collagen content induced by partial narrowing of abdominal aorta.
To investigate the reversing effects of DDPH on cardiac hypertrophy and increased collagen content in left ventricle tissue of rats, cardiac hypertrophy of rats were induced by partial narrowing of abdominal aorta. 4 weeks after operation, the rats were given DDPH for 8 weeks. 12 weeks later, it was found that in model group, LVW/WHW and WHW/BW increased by 39.0% and 36.9% than those in control group; collagen content increased by 1.5 times. I phi/E phi, LS decreased (P < 0.01), MMW/E phi, WZ increased (P < 0.01). The above-mentioned changes in two DDPH groups could be partly or completely reversed. It is concluded that DDPH could reverse cardiac hypertrophy of rats induced by partial narrowing of abdominal aorta and reduce collagen content in left ventricle tissue.
Zhang
Z
Z
Department of Pharmacology, Tongji Medical University, Wuhan.
Li
W
W
Qian
J
J
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D001012:Aorta, Abdominal / Q000473:pathology; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D006332:Cardiomegaly / Q000378:metabolism / Q000473:pathology*; D003094:Collagen / Q000378:metabolism*; D003250:Constriction; D008297:Male; D010627:Phenethylamines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000317:Adrenergic alpha-Antagonists; D002121:Calcium Channel Blockers; D010627:Phenethylamines; C057485:1-(2,6-dimethylphenoxy)-2-(3,4-dimethoxyphenylethylamino)propane; D003094:Collagen