Coagulation and fibrinolysis parameters in normal pregnancy and in gestational diabetes.
The changes in coagulation and fibrinolysis parameters during pregnancy, delivery and 3 days after delivery were evaluated in normotensive and gestational diabetes pregnant women. Normal pregnant women (n = 60) and pregnant women with gestational diabetes (n = 15) formed the study population. Coagulation and fibrinolysis parameters were estimated using commercial tests. Antithrombin III, thrombin-antithrombin III complexes, heparin cofactor II, protein C, protein S, tissue plasminogen activator, (t-PA) D-dimer and plasminogen activator inhibitor (PAI-1 and PAI-2) activities in normal and gestational diabetes pregnancies were determined. Thrombin-antithrombin III complexes increased and coagulation inhibitors decreased in gestational diabetes. Plasminogen activator inhibitors remained unchanged and t-PA levels increased in gestational diabetes.
Bellart
J
J
Servei d'Obstetrícia i Ginecologia, Unitat de Medicina Materno-fetal, Hospital Universitari de Tarragona Joan XXIII, Spain.
Gilabert
R
R
Fontcuberta
J
J
Carreras
E
E
Miralles
R M
RM
Cabero
L
L
D000328:Adult; D001777:Blood Coagulation; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D007743:Labor, Obstetric / Q000097:blood*; D049590:Postpartum Period / Q000097:blood*; D011247:Pregnancy / Q000097:blood*; D011264:Pregnancy Trimesters