title: Localization of endothelin-like immunoreactivity in the hypothalamo-neurohypophysial system of the rat after ischemia.
abstract: Endothelin is a very powerful endogenous vasoconstrictor substance produced by endothelial cells. To examine the potential role of endothelin as a neuropeptide, we studied its distribution in the neurosecretory system. Endothelin-like immunoreactivity (EN-IR) has been demonstrated by an immunogold method in the paraventricular and supraoptic nuclear neurons and their terminals in the posterior pituitary of the rat. ET-IR was enhanced after ischemia suggesting its modulatory role in neurosecretory functions.
authors.affiliation: Laboratory of the Ultrastructure of Nervous System, Polish Academy of Sciences, Warszawa, Poland.
authors.forename: B
authors.initials: B
authors.lastname: Gajkowska
authors.forename: A
authors.initials: A
authors.lastname: Viron
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000473:pathology*; D016232:Endothelins / Q000032:analysis*; D007030:Hypothalamo-Hypophyseal System / Q000737:chemistry*; D007150:Immunohistochemistry; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D016232:Endothelins