Differential effects of high salt intake on neuropeptide Y and adrenergic markers in hearts of Dahl rats.
Adrenergic markers and neuropeptide Y (NPY) were examined in Dahl NaCl-sensitive and -resistant outbred male rats, fed either 0.35% or 8% NaCl diets for 8 weeks. The high salt diet caused left ventricular hypertrophy in sensitive rats but not in the resistant strain. Norepinephrine stores were not affected by high salt intake, but tyrosine hydroxylase, and dopamine beta-hydroxylase were elevated in the salt-induced hypertrophied left ventricle in conjunction with increased levels of nerve growth factor and p75 neurotrophin receptor. In contrast, high salt intake reduced ventricular neuropeptide Y in both Dahl salt-resistant and -sensitive rats.
Nyquist-Battie
C
C
Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri-Kansas City, USA. cnyquist@unf.edu
Cochran
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P
Chronwall
B M
BM
D018663:Adrenergic Agents / Q000378:metabolism*; D000818:Animals; D017379:Hypertrophy, Left Ventricular / Q000473:pathology; D008297:Male; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D009414:Nerve Growth Factors / Q000378:metabolism; D009478:Neuropeptide Y / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D020303:Rats, Inbred Dahl; D017673:Sodium Chloride, Dietary / Q000009:adverse effects / Q000378:metabolism*; D013564:Sympathetic Nervous System / Q000378:metabolism
D018663:Adrenergic Agents; D009414:Nerve Growth Factors; D009478:Neuropeptide Y; D017673:Sodium Chloride, Dietary; D009638:Norepinephrine