title: Multicentric reticulohistiocytosis associated with recurrent breast carcinoma.
abstract: Multicentric reticulohistiocytosis (MRH) is a rare systemic disorder that most often affects women in the fourth to fifth decades of life and is characterized by widespread cutaneous papules and nodules, often associated with a destructive arthritis. The characteristic histologic feature of the skin lesions, and of other affected organs, is the presence of histiocytes and multinucleated giant cells containing abundant eosinophilic cytoplasm with a "ground glass appearance." Approximately 30% of the patients have an underlying malignancy suggesting MRH may be a paraneoplastic phenomenon. We describe a case of MRH associated with recurrent, metastatic breast carcinoma.
authors.affiliation: Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, FL, USA.
authors.forename: I C
authors.initials: IC
authors.lastname: Valencia
authors.forename: A
authors.initials: A
authors.lastname: Colsky
authors.forename: B
authors.initials: B
authors.lastname: Berman
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000150:complications*; D018270:Carcinoma, Ductal, Breast / Q000150:complications* / Q000556:secondary; D003593:Cytoplasm / Q000648:ultrastructure; D005260:Female; D005384:Finger Joint / Q000473:pathology; D015726:Giant Cells / Q000473:pathology; D006229:Hand Dermatoses / Q000209:etiology* / Q000473:pathology; D006644:Histiocytes / Q000473:pathology; D015616:Histiocytosis, Non-Langerhans-Cell / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007592:Joint Diseases / Q000209:etiology / Q000473:pathology; D007719:Knee Joint / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000150:complications*; D010257:Paraneoplastic Syndromes / Q000209:etiology* / Q000473:pathology