title: Use of USPIO-induced magnetic susceptibility artifacts to identify sentinel lymph nodes and lymphatic drainage patterns. I. Dependence of artifact size with subcutaneous Combidex dose in rats.
abstract: Subcutaneously administered Combidex contrast agent produced characteristic magnetic susceptibility artifacts in gradient-echo (GE) images of rat brachial and axillary lymph nodes. These artifacts were useful in the rapid location and identification of normal sentinel lymph nodes. A linear dose response was observed with maximum artifact size in transverse images and was used noninvasively to study lymphatic drainage patterns.
authors.affiliation: Advanced Magnetics, Inc., Cambridge, MA 02138-1038, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Rogers
authors.forename: C W
authors.initials: CW
authors.lastname: Jung
authors.forename: J
authors.initials: J
authors.lastname: Lewis
authors.forename: E V
authors.initials: EV
authors.lastname: Groman
mesh_terms: D000818:Animals; D016477:Artifacts; D001365:Axilla; D003287:Contrast Media / Q000008:administration & dosage*; D003911:Dextrans; D052203:Ferrosoferric Oxide; D007501:Iron / Q000008:administration & dosage; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000175:diagnosis; D008208:Lymphatic System / Q000473:pathology; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles; D008297:Male; D010087:Oxides / Q000008:administration & dosage; D051381:Rats
chemical_list: D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; D010087:Oxides; C097921:ferumoxtran-10; D007501:Iron; D052203:Ferrosoferric Oxide