title: Autoregulation of human inner ear blood flow during middle ear surgery with propofol or isoflurane anesthesia during controlled hypotension.
abstract: We used controlled hypotension to obtain a bloodless cavity during middle ear surgery under an optical microscope. No previous study has assessed the effect of controlled hypotension on inner ear blood flow (IEF) autoregulation in humans receiving propofol or isoflurane anesthesia. In the present study, the IEF autoregulation was determined using laser Doppler flowmetry in combination with transient evoked otoacoustic emissions (TEOAEs) during controlled hypotension with sodium nitroprusside in 20 patients randomly anesthetized with propofol or isoflurane. A coefficient of IEF autoregulation (Ga) was determined during controlled hypotension, with a Ga value ranging between 0 (no autoregulation) and 1 (perfect autoregulation). During controlled hypotension with propofol, IEF remained stable (1%+/-6%; P > 0.05) but decreased by 25%+/-8% with isoflurane (P < 0.05). The Ga was higher during propofol anesthesia (0.62+/-0.03) than during isoflurane anesthesia (0.22+/-0.03; P < 0.0001). Under propofol anesthesia, there were individual relationships between TEOAE amplitude and change in IEF in four patients. Such a correlation was not observed under isoflurane anesthesia. These results suggest that human IEF is autoregulated in response to decreased systemic pressure. Furthermore, isoflurane has a greater propensity to decrease cochlear autoregulation and function than propofol.
  
  
  CONCLUSIONS
  The present study shows that inner ear blood flow is autoregulated under propofol, but not isoflurane, anesthesia during controlled hypotension in humans during middle ear surgery. Further studies are needed to explore the postoperative auditory functional consequences of the choice of the anesthetic drug used in middle ear surgery.
authors.affiliation: Service d'Anesthésie Réanimation, Centre Hospitalier Universitaire, Angers, France. Marie-Pierre.Preckel@univ-angers.fr
authors.forename: M P
authors.initials: MP
authors.lastname: Preckel
authors.forename: C
authors.initials: C
authors.lastname: Ferber-Viart
authors.forename: G
authors.initials: G
authors.lastname: Leftheriotis
authors.forename: C
authors.initials: C
authors.lastname: Dubreuil
authors.forename: R
authors.initials: R
authors.lastname: Duclaux
authors.forename: J L
authors.initials: JL
authors.lastname: Saumet
authors.forename: V
authors.initials: V
authors.lastname: Banssillon
authors.forename: J C
authors.initials: JC
authors.lastname: Granry
mesh_terms: D000328:Adult; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D007758:Ear, Inner / Q000098:blood supply*; D004432:Ear, Middle / Q000601:surgery*; D005072:Evoked Potentials, Auditory / Q000502:physiology; D005260:Female; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007023:Hypotension, Controlled; D007530:Isoflurane; D008297:Male; D015742:Propofol; D012039:Regional Blood Flow / Q000502:physiology; D013997:Time Factors
chemical_list: D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D007530:Isoflurane; D015742:Propofol