Outcomes of transposition of the great arteries in the ear of atrial inflow correction.
OBJECTIVE
To examine long term morbidity and mortality following atrial inflow corrective procedures for transposition of the great arteries (TGA) and to investigate factors that influence morbidity and mortality.


METHODS
Retrospective cohort study from a single centre.


METHODS
Cardiology and cardiothoracic surgical unit in a large tertiary referral centre.


METHODS
All 130 patients who had TGA diagnosed between August 1972 and May 1988 and were considered suitable for atrial inflow correction; 109 of these underwent surgery (operative cohort: 84 Mustard operations and 25 Senning operations); 95 survived to hospital discharge (hospital surviving cohort).


METHODS
Death and cardiac events.


RESULTS
There were relatively good long term results from atrial inflow correction for TGA with 5, 10, and 15 year survivals of 77.3%, 75.9%, and 71.3%. However, there was an appreciable incidence of late cardiac death and events, with 5, 10, and 15 year cardiac event-free survivals of 74.5%, 67.1%, and 39.6%. Supraventricular tachycardia was the only significant risk factor for late cardiac death (relative risk 8.72, 95% confidence interval, 2.86 to 26.64). Senning patients had better event-free survival (p = 0.04).


CONCLUSIONS
Atrial inflow correction for TGA has a reasonably good 15 year survival (71.3%), but there is an appreciable incidence of late cardiac deaths and events (15 year event-free survival 39.6%). The Senning procedure is preferable to the Mustard procedure for cases unsuitable for arterial switching.
Birnie
D
D
Department of Medicine and Therapeutics, Glasgow University, Western Infirmary, UK.
Tometzki
A
A
Curzio
J
J
Houston
A
A
Hood
S
S
Swan
L
L
Doig
W
W
Wilson
N
N
Jamieson
M
M
Pollock
J
J
Hillis
W S
WS
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D016757:Death, Sudden, Cardiac / Q000209:etiology; D006325:Heart Atria / Q000601:surgery; D006801:Humans; D007223:Infant; D009017:Morbidity; D011183:Postoperative Complications / Q000401:mortality; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D013617:Tachycardia, Supraventricular / Q000150:complications; D014188:Transposition of Great Vessels / Q000150:complications / Q000401:mortality* / Q000601:surgery*; D016896:Treatment Outcome