[Genetic susceptibility to multiple sclerosis (MS). INSERM Network of Clinical Research on the Genetic Susceptibility to MS].
The clinical manifestations and neuropathological signs of Multiple Sclerosis (MS) have been known for more than a century, but the cause of MS remains unknown. Epidemiological studies indicate that MS is a multi-factorial disease implicating both environmental factors and genetic susceptibility. The role of HLA in the genetic susceptibility to MS has been known since the seventies. Advances in human genetics now allow a systematic approach to genetic susceptibility in MS: possible strategies are reviewed.
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Fédération de Neurologie, Groupe Hospitalier Pitié-Salpêtrière, Paris.
D020022:Genetic Predisposition to Disease; D006801:Humans; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000235:genetics*; D010375:Pedigree; D015995:Prevalence