title: Angiogenesis in P- and E-selectin-deficient mice.
abstract: OBJECTIVE
  Several observations reported earlier indicated that the selectins, in particular E-selectin, might be involved in angiogenesis; however, mice deficient in the endothelial selectins develop normally. To clarify the role of endothelial selectins in angiogenesis, we have studied experimentally induced angiogenesis in selectin-deficient mice.
  
  
  METHODS
  Hydron pellets containing either basic fibroblast growth factor or the inflammatory cytokine tumor necrosis factor alpha were implanted into the corneas of wild-type and P- and/or E-selectin-deficient mice.
  
  
  RESULTS
  The lengths and circumferential range of the newly formed blood vessels in the corneas of the endothelial selectin-deficient mice were similar to those of wild-type mice.
  
  
  CONCLUSIONS
  The endothelial selectins are not essential in experimentally induced angiogenesis in vivo.
authors.affiliation: Center for Blood Research, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: D W
authors.initials: DW
authors.lastname: Hartwell
authors.forename: C E
authors.initials: CE
authors.lastname: Butterfield
authors.forename: P S
authors.initials: PS
authors.lastname: Frenette
authors.forename: B M
authors.initials: BM
authors.lastname: Kenyon
authors.forename: R O
authors.initials: RO
authors.lastname: Hynes
authors.forename: J
authors.initials: J
authors.lastname: Folkman
authors.forename: D D
authors.initials: DD
authors.lastname: Wagner
mesh_terms: D000818:Animals; D003315:Cornea / Q000098:blood supply / Q000187:drug effects; D019040:E-Selectin / Q000235:genetics / Q000502:physiology*; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D018919:Neovascularization, Physiologic / Q000187:drug effects; D019007:P-Selectin / Q000235:genetics / Q000502:physiology*; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D019040:E-Selectin; D019007:P-Selectin; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D016222:Fibroblast Growth Factor 2