Effects of nimodipine on acute cerebral ischemia and reperfusion injury of rats.
OBJECTIVE
To study the effect of nimodipine (Nim) on ischemic cerebral damage.


METHODS
The four-vessel occlusion method was performed on rats. Monoamines were measured by fluorospectrophotometry.


RESULTS
Intraperitoneal injection of Nim 0.75 and 1.5 mg.kg-1 quickened the recovery of EEG changes to 19 +/- 3 and 17 +/- 4 min (P < 0.01), respectively. Nim reduced the decreases of monoamines (NE, DA, 5-HT, and 5-HIAA) contents after 30-min cerebral ischemia and 1-h reperfusion.


CONCLUSIONS
Nim protects the brain from ischemic damage.
He
M X
MX
Department of Pharmacology, He-nan Medical University, Zhengzhou, China.
Ke
J
J
Li
Z G
ZG
Liu
F Z
FZ
D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism; D002545:Brain Ischemia / Q000188:drug therapy*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000378:metabolism; D004569:Electroencephalography / Q000187:drug effects; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D009553:Nimodipine / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000378:metabolism
D015306:Biogenic Monoamines; D002121:Calcium Channel Blockers; D009553:Nimodipine