title: Evaluating medication response in ADHD: cognitive, behavioral, and single-subject methodology.
abstract: Although evidence supports the use of double-blind placebo medication trials to evaluate methylphenidate (MPH) effects on the core behavioral symptoms of attention-deficit/hyperactivity disorder (ADHD), few studies have demonstrated their utility in examining MPH effects on the cognitive deficits associated with ADHD. This article presents a technique for evaluating behavioral and cognitive dose-response relationships at the single-subject level of analysis. Case study results and multivariate analyses suggest that systematic evaluation of behavioral and cognitive MPH dose-response relationships could lead to more accurate MPH titration and greater long-term multimodal treatment efficacy.
authors.affiliation: School of Psychology Program, Moorhead State University, MN 56563, USA.
authors.forename: J B
authors.initials: JB
authors.lastname: Hale
authors.forename: J A
authors.initials: JA
authors.lastname: Hoeppner
authors.forename: M B
authors.initials: MB
authors.lastname: DeWitt
authors.forename: D L
authors.initials: DL
authors.lastname: Coury
authors.forename: D G
authors.initials: DG
authors.lastname: Ritacco
authors.forename: B
authors.initials: B
authors.lastname: Trommer
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000145:classification / Q000188:drug therapy*; D000697:Central Nervous System Stimulants / Q000008:administration & dosage* / Q000009:adverse effects; D002648:Child; D002652:Child Behavior / Q000187:drug effects; D002985:Clinical Protocols; D003071:Cognition / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000008:administration & dosage* / Q000009:adverse effects; D015999:Multivariate Analysis; D009483:Neuropsychological Tests; D016896:Treatment Outcome
chemical_list: D000697:Central Nervous System Stimulants; D008774:Methylphenidate