Molecular mechanisms for the regulation of the expression and function of muscarinic acetylcholine receptors.
The regulation of muscarinic acetylcholine receptor expression and function was investigated in cultured cells and in knockout mice. Muscarinic agonist exposure causes m2 receptor desensitization and sequestration and decreases the expression of cardiac potassium channels. The expression of m2 receptors in chick retina is regulated by a developmentally regulated secreted factor. Mice lacking the m1 receptor exhibit a loss of muscarinic regulation of M-current potassium channel activity and pilocarpine-induced seizures.
Hamilton
S E
SE
Department of Pharmacology, University of Washington, Seattle 98195-7750, USA.
Schlador
M L
ML
McKinnon
L A
LA
Chmelar
R S
RS
Nathanson
N M
NM
D000818:Animals; D002478:Cells, Cultured; D019204:GTP-Binding Proteins / Q000378:metabolism; D005786:Gene Expression Regulation / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D011499:Protein Processing, Post-Translational; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism; D011976:Receptors, Muscarinic / Q000235:genetics / Q000502:physiology*; D014158:Transcription, Genetic
D011976:Receptors, Muscarinic; D020794:Receptor Protein-Tyrosine Kinases; D019204:GTP-Binding Proteins