title: Accumulation of F-spondin in injured peripheral nerve promotes the outgrowth of sensory axons.
abstract: F-spondin, an extracellular matrix protein, is present in peripheral nerve during embryonic development, but its amount diminishes by birth. Axotomy of adult rat sciatic nerve, however, causes a massive upregulation of both F-spondin mRNA and protein distal to the lesion. F-spondin in the distal stump of axotomized nerve promotes neurite outgrowth of sensory neurons, as revealed by protein neutralization with F-spondin-specific antibodies. Thus, F-spondin is likely to play a role in promoting axonal regeneration after nerve injury.
authors.affiliation: Department of Anatomy and Cell Biology, The Hebrew University-Hadassah Medical School, Jerusalem, 91120 Israel.
authors.forename: T
authors.initials: T
authors.lastname: Burstyn-Cohen
authors.forename: A
authors.initials: A
authors.lastname: Frumkin
authors.forename: Y T
authors.initials: YT
authors.lastname: Xu
authors.forename: S S
authors.initials: SS
authors.lastname: Scherer
authors.forename: A
authors.initials: A
authors.lastname: Klar
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000906:Antibodies / Q000494:pharmacology; D001369:Axons / Q000502:physiology*; D019771:Axotomy; D015152:Blotting, Northern; D002478:Cells, Cultured; D005109:Extracellular Matrix / Q000378:metabolism; D005786:Gene Expression Regulation; D006133:Growth Substances; D017403:In Situ Hybridization; D036341:Intercellular Signaling Peptides and Proteins; D009416:Nerve Regeneration; D019006:Neural Cell Adhesion Molecules / Q000276:immunology / Q000378:metabolism*; D016501:Neurites / Q000187:drug effects / Q000502:physiology; D009475:Neurons, Afferent / Q000502:physiology*; D010455:Peptides; D059348:Peripheral Nerve Injuries; D010525:Peripheral Nerves / Q000196:embryology / Q000378:metabolism*; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017207:Rats, Sprague-Dawley; D012583:Schwann Cells; D012584:Sciatic Nerve
chemical_list: D000906:Antibodies; D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins; D019006:Neural Cell Adhesion Molecules; D010455:Peptides; D012333:RNA, Messenger; C498955:Spon1 protein, rat