Partial seizures associated with antiphospholipid antibodies in childhood.
We report antiphospholipid antibody positivity in three of a consecutive series of 23 children presenting partial epileptic seizures. There was no clinical or serological evidence of systemic lupus erythematosus or other connective-tissue disease. Neither computed tomography nor magnetic resonance imaging revealed ischemic alteration. The presence of antiphospholipid antibodies in 3/23 children may indicate that immune-mediated neuronal damage could be a pathogenetic mechanism for partial epilepsy.
Angelini
L
L
Department of Neuropediatrics, National Neurological Institute C. Besta, Milano, Italy.
Granata
T
T
Zibordi
F
F
Binelli
S
S
Zorzi
G
G
Besana
C
C
D000293:Adolescent; D017153:Antibodies, Anticardiolipin / Q000097:blood; D017152:Antibodies, Antiphospholipid / Q000097:blood*; D000927:Anticonvulsants / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000150:complications / Q000175:diagnosis; D002220:Carbamazepine / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000188:drug therapy / Q000276:immunology*; D005260:Female; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000097:blood; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D014635:Valproic Acid / Q000627:therapeutic use
D017153:Antibodies, Anticardiolipin; D017152:Antibodies, Antiphospholipid; D000927:Anticonvulsants; D016682:Lupus Coagulation Inhibitor; D002220:Carbamazepine; D014635:Valproic Acid; D011241:Prednisone