title: Interaction between carotid baroregulation and the pulsating heart: a mathematical model.
abstract: A mathematical model of short-term arterial pressure control by the carotid baroreceptors in pulsatile conditions is presented. The model includes an elastance variable description of the left and right heart, the systemic (splanchnic and extrasplanchnic) and pulmonary circulations, the afferent carotid baroreceptor pathway, the sympathetic and vagal efferent activities, and the action of several effector mechanisms. The latter mechanisms work, in response to sympathetic and vagal action, by modifying systemic peripheral resistances, systemic venous unstressed volumes, heart period, and end-systolic elastances. The model is used to simulate the interaction among the carotid baroreflex, the pulsating heart, and the effector responses in different experiments. In all cases, there has been satisfactory agreement between model and experimental results. Experimental data on heart rate control can be explained fairly well by assuming that the sympathetic-parasympathetic systems interact linearly on the heart period. The carotid baroreflex can significantly modulate the cardiac function curve. However, this effect is masked in vivo by changes in arterial and atrial pressures. During heart pacing, cardiac output increases with frequency at moderate levels of heart rate and then fails to increase further because of a reduction in stroke volume. Shifting from nonpulsatile to pulsatile perfusion of the carotid sinuses decreases the overall baroreflex gain and significantly modifies operation of the carotid baroreflex. Finally, a sensitivity analysis suggests that venous unstressed volume control plays the major role in the early hemodynamic response to acute hemorrhage, whereas systemic resistance and heart rate controls are a little less important.
authors.affiliation: Department of Electronics, Computer Science and Systems, University of Bologna, I40136 Bologna, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Ursino
mesh_terms: D000818:Animals; D017704:Baroreflex / Q000502:physiology*; D002339:Carotid Arteries / Q000502:physiology*; D006321:Heart / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D008962:Models, Theoretical; D009200:Myocardial Contraction / Q000502:physiology