[Analgesic and anti-inflammatory activity of saponins of Argania spinoza].
We studied analgesic and antiinflammatory actions of saponins of Argania spinosa cakes in mice and rats. With oral doses of 50 to 300 mg/kg, we found peripheric analgesic actions equivalent to the acetyl salicylic acid ones. The maximum protection was obtained with 500 mg/kg per os. There is no morphine-like central analgesic effect. Antiinflammatory studies were done in vivo using oedema due to carrageenine or experimental trauma in rats. There was a decrease in the paw swelling at doses of 10 mg/kg per os. At doses of 50 to 100 mg/kg per os, the antiinflammatory effect was similar to the one of indomethacin at doses of 10 to 20 mg/kg per os. In vitro, there was an inhibition of beef synovial fluid degradation by OH. radicals. The inhibition action is evaluated with an IC20 > or = 6 microM. Argania spinosa saponins have also an antiradical action against DPPH (IC25 = 85 mM) and against OH. radicals (IC25 = 0.56 M). Since they do not have any inhibition effect on PGE2 synthesis, their antiinflammatory activity can be explained by their action on leucotriens in the metabolic pathway of arachidonic acid.
Alaoui
K
K
Laboratoire de Pharmacologie et Toxicologie, Faculté de Médecine et de Pharmacie, Rabat Instituts, Agdal, Maroc.
Lagorce
J F
JF
Cherrah
Y
Y
Hassar
M
M
Amarouch
H
H
Roquebert
J
J
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology; D004487:Edema; D007213:Indomethacin / Q000494:pharmacology; D051379:Mice; D010146:Pain; D051381:Rats; D012503:Saponins / Q000494:pharmacology*; D014197:Trees
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D012503:Saponins; D001241:Aspirin; D007213:Indomethacin