Interstitial cystitis. Ultrastructural observations on detrusor smooth muscle cells.
Ultrastructural investigation of detrusor muscle cells in biopsies from 13 patients (8 interstitial cystitis (IC) and 5 controls) was performed. In all IC-patients and in one control a varying number of smooth muscle cells revealed a characteristic oak leaf pattern with protrusions of the sarcolemma. The alterations may express degeneration of smooth muscle cells. Although most probably non-specific yet highly characteristic, the ultrastructural detrusor changes may be important in diagnosing IC.
Horn
T
T
Department of Pathology, Herlev Hospital, University of Copenhagen, Denmark.
Holm
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NR
Hald
T
T
D008841:Actin Cytoskeleton / Q000648:ultrastructure; D000328:Adult; D000368:Aged; D001706:Biopsy; D018856:Cystitis, Interstitial / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D008928:Mitochondria / Q000648:ultrastructure; D009130:Muscle, Smooth / Q000648:ultrastructure*; D001743:Urinary Bladder / Q000648:ultrastructure*