[Effects of deltamethrin on the binding of glutamate receptor to rat cerebral cortical synaptosomal membrane].
Effects of deltamethrin on the binding function of glutamate receptor of cerebral cortical synaptosomal membrane in rat were studied by radio-labeled ligand receptor binding assay. Results showed that deltamethrin could obviously increase the 3H-glutamate binding to synaptosomal membrane, by doses of 1 x 10(-8) to 1 x 10(-4) mol/L, with a dose-dependent relationship. Glutamate binding rate increased by 3.2 percent to 13.5 percent in deltamethrin treated group, as compared with dimethyl sulfoxide solvent controls. Binding dynamic analysis of receptor and ligand showed that an obvious synergistic action of deltamethrin and dimethyl sulfoxide. It indicated that neurotoxicity of deltamethrin could be related to the disturbance of central transmitter system of glutamate.
Zhao
X
X
Institute of Environmental Health Monitoring, Chinese Academy of Medical Sciences, Beijing.
Zhu
X
X
Shi
N
N
D000818:Animals; D001667:Binding, Competitive; D002540:Cerebral Cortex / Q000378:metabolism*; D004121:Dimethyl Sulfoxide / Q000633:toxicity; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D009570:Nitriles; D011722:Pyrethrins / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017470:Receptors, Glutamate / Q000187:drug effects / Q000378:metabolism*; D013570:Synaptic Membranes / Q000378:metabolism*
D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; D017470:Receptors, Glutamate; C017180:decamethrin; D004121:Dimethyl Sulfoxide