Increase of nerve regeneration capacity by new neurotrophic pyrimidine derivative MS-430.
1. We studied whether a new neurotrophic pyrimidine compound, MS-430, can increase the regeneration length of the transected sciatic nerve in a silicone chamber gap of 14 mm. 2. The average length of regenerated myelinated axons in ten cases was 9.0+/-0 mm in the control group, 2.8+/-1.9 mm in the 1 mg/kg/day of the MS-430 group and 5.0+/-5.1 mm in the 3 mg/kg/day of the MS-430 group, indicating that the average length was significantly larger in the 3-mg group than that in the control group (P<0.05). 3. The results clearly showed that the MS-430 has promoting effects on nerve regeneration.
Noda
M
M
Orthopedic Surgery, Matsuyama Red Cross Hospital, Japan.
Ochi
M
M
Ikuta
Y
Y
Awaya
A
A
D000818:Animals; D001369:Axons / Q000187:drug effects / Q000502:physiology; D005260:Female; D009186:Myelin Sheath / Q000187:drug effects / Q000502:physiology; D009416:Nerve Regeneration / Q000187:drug effects*; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure
C093088:MS 430; D011743:Pyrimidines