title: The European trial on reduction of cardiac events with perindopril in stable coronary artery disease (EUROPA).
abstract: BACKGROUND
  Angiotensin-converting enzyme (ACE) inhibitors have an accepted place in the treatment of hypertension and heart failure. However, at present they have no specific role in the prevention or treatment of coronary artery disease: evidence from animal experiments and some of the large ACE inhibitor cardiac studies makes this effect well worth testing.
  
  
  OBJECTIVE
  The objective of EUROPA is to assess the effects of perindopril (an ACE inhibitor) on outcome in patients with stable coronary artery disease, but no clinical heart failure.
  
  
  METHODS
  This is a double-blind, placebo-controlled, multicentre study with a duration of 3.5 years. It is proposed to recruit 10500 patients from 24 countries in Europe. The primary end-point is a combined one: total mortality, non-fatal acute myocardial infarction, unstable angina pectoris and cardiac arrest with successful resuscitation are included; the outcome is studied in patients with proven coronary artery disease and no clinical heart failure. Secondary end-points consist of these events individually calculated. The first patient was recruited in October 1997, and it is planned to finish recruitment by the end of 1998.
authors.affiliation: The Royal Brompton and Harefield NHS Trust, London, UK.
authors.forename: K M
authors.initials: KM
authors.lastname: Fox
authors.forename: J R
authors.initials: JR
authors.lastname: Henderson
authors.forename: M E
authors.initials: ME
authors.lastname: Bertrand
authors.forename: R
authors.initials: R
authors.lastname: Ferrari
authors.forename: W J
authors.initials: WJ
authors.lastname: Remme
authors.forename: M L
authors.initials: ML
authors.lastname: Simoons
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000150:complications / Q000517:prevention & control; D003327:Coronary Disease / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality; D004311:Double-Blind Method; D005060:Europe; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D020913:Perindopril; D011379:Prognosis; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D007211:Indoles; D020913:Perindopril