title: Partial seizures associated with antiphospholipid antibodies in childhood.
abstract: We report antiphospholipid antibody positivity in three of a consecutive series of 23 children presenting partial epileptic seizures. There was no clinical or serological evidence of systemic lupus erythematosus or other connective-tissue disease. Neither computed tomography nor magnetic resonance imaging revealed ischemic alteration. The presence of antiphospholipid antibodies in 3/23 children may indicate that immune-mediated neuronal damage could be a pathogenetic mechanism for partial epilepsy.
authors.affiliation: Department of Neuropediatrics, National Neurological Institute C. Besta, Milano, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Angelini
authors.forename: T
authors.initials: T
authors.lastname: Granata
authors.forename: F
authors.initials: F
authors.lastname: Zibordi
authors.forename: S
authors.initials: S
authors.lastname: Binelli
authors.forename: G
authors.initials: G
authors.lastname: Zorzi
authors.forename: C
authors.initials: C
authors.lastname: Besana
mesh_terms: D000293:Adolescent; D017153:Antibodies, Anticardiolipin / Q000097:blood; D017152:Antibodies, Antiphospholipid / Q000097:blood*; D000927:Anticonvulsants / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000150:complications / Q000175:diagnosis; D002220:Carbamazepine / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000188:drug therapy / Q000276:immunology*; D005260:Female; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000097:blood; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D014635:Valproic Acid / Q000627:therapeutic use
chemical_list: D017153:Antibodies, Anticardiolipin; D017152:Antibodies, Antiphospholipid; D000927:Anticonvulsants; D016682:Lupus Coagulation Inhibitor; D002220:Carbamazepine; D014635:Valproic Acid; D011241:Prednisone