[Preventive effects of tetrandrine on pulmonary hypertension and right ventricular hypertrophy in rats induced by monocrotaline].
Pulmonary hypertension and right ventricular hypertrophy in rats were developed 3 weeks after administration of monocrotaline 50 mg/kg i.p. Tetrandrine 10 mg/kg and 15 mg/kg bid p.o. could prevent the above-said effects produced by monocrotaline.
Jin
X
X
Pharmacology Department, China Medical University, Shenyang.
Zhang
X
X
Xing
J
J
Liu
K
K
Wang
H
H
D000470:Alkaloids / Q000627:therapeutic use*; D000818:Animals; D044182:Benzylisoquinolines; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D006976:Hypertension, Pulmonary / Q000139:chemically induced / Q000517:prevention & control*; D017380:Hypertrophy, Right Ventricular / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D016686:Monocrotaline; D051381:Rats; D017208:Rats, Wistar
D000470:Alkaloids; D044182:Benzylisoquinolines; D002121:Calcium Channel Blockers; C009438:tetrandrine; D016686:Monocrotaline