title: Five-year mortality in elderly French subjects from the PAQUID epidemiologival survey: the burden of diabetes.
abstract: We describe the 5-year mortality and its risk factors in a cohort of elderly people with and without known diabetes mellitus. The PAQUID cohort was representative of the population older than 65 living in Gironde, south-west France. Potential mortality risk factors were collected during a baseline evaluation, using a health questionnaire, from 68.9% of a randomly selected sample of over-65s in 1988. A total of 237 subjects (8.5%) had diabetes. Annual review occurred for 5 years and cause of any death was ascertained from family doctors. After 5 years, 623 people (22.3%) had died, of whom 576 were non-demented; 30.0% of the diabetic group versus 20.3% of the non-diabetic group had died. Survival of the known diabetic group was lower than that of the non-diabetic group (p < 0.001), although this excess mortality was significant only in the 65 to 75 age range (relative risk 1.8; 95% confidence interval 1.2 to 2.8, p = 0.04). Cardiovascular mortality rate did not differ between the diabetic and non-diabetic groups (RR 1.2 [0.8-2.0]). Death related to neoplasia was significantly higher in the known diabetic group (RR 2.2 [1.2-3.3], p = 0.01). In the final model, integrating diabetes as a mortality risk factor in the total cohort, known diabetes at the baseline examination was an independent risk factor for mortality (RR 1.4 [1.0-1.8], p = 0.01), in addition to tobacco use, hypertension and functional dependency. These results confirm suggestions that diabetes increases mortality in the over-65 age group, perhaps with an adverse interaction with other pathology.
authors.affiliation: Centre de Gériatrie du Centre Hospitalo, Universitaire de Bordeaux, Hôpital Xavier-Arnozan, Pessac, France. jean-paul.emeriau@chu-acquitaine.fr
authors.forename: I
authors.initials: I
authors.lastname: Bourdel-Marchasson
authors.forename: B
authors.initials: B
authors.lastname: Dubroca
authors.forename: A
authors.initials: A
authors.lastname: Decamps
authors.forename: S
authors.initials: S
authors.lastname: Richard-Harston
authors.forename: J P
authors.initials: JP
authors.lastname: Emeriau
authors.forename: J F
authors.initials: JF
authors.lastname: Dartigues
mesh_terms: D000368:Aged; D002423:Cause of Death; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000401:mortality*; D005260:Female; D005602:France / Q000453:epidemiology; D015577:Geriatric Assessment / Q000706:statistics & numerical data; D006304:Health Status; D006306:Health Surveys; D006801:Humans; D008297:Male; D011159:Population Surveillance; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D011795:Surveys and Questionnaires; D015996:Survival Rate / Q000639:trends; D014504:Urban Health / Q000706:statistics & numerical data / Q000639:trends