IgA glomerulonephritis with irregular intramembranous dense deposits.
A 30-year-old white male presented with hematuria, proteinuria and normal renal function following a flu-like illness. IgA was mildly elevated but C3 and C4 levels were normal in serum. Renal biopsy showed a mesangial proliferative nephritis with immunohistochemical features of IgA nephritis but with an unusual pattern and distribution of deposits in glomerular, tubular and Bowman's capsular basement membranes.
Katz
A
A
The Toronto Hospital, Western Division and Scarborough Centenary Health Centre, Toronto, Ont., Canada.
Chan
P
P
D000328:Adult; D001485:Basement Membrane / Q000473:pathology*; D001706:Biopsy; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D005920:Glomerular Mesangium / Q000473:pathology; D005922:Glomerulonephritis, IGA / Q000175:diagnosis* / Q000473:pathology*; D006417:Hematuria / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007150:Immunohistochemistry; D007678:Kidney Glomerulus / Q000473:pathology; D007687:Kidney Tubules, Proximal / Q000473:pathology; D008297:Male; D011507:Proteinuria / Q000175:diagnosis / Q000209:etiology
D003176:Complement C3; D003181:Complement C4; D007070:Immunoglobulin A