title: Multicentric osteosarcoma, Rothmund-Thomson syndrome, and secondary nasopharyngeal non-Hodgkin's lymphoma: a case report and review of the literature.
abstract: OBJECTIVE
  Rothmund-Thomson syndrome (RTS) is an autosomal recessive disease characterized by poikiloderma, photosensitivity, skeletal deformities, and other changes. It is also associated with an increased risk of malignancies, including osteosarcoma. Sixteen previous cases of RTS and osteosarcoma have been reported.
  
  
  METHODS
  A patient with RTS in whom multicentric osteosarcoma developed is described. After surgery and chemotherapy, a secondary malignant neoplasm (SMN) developed consistent with nasopharyngeal non-Hodgkin's lymphoma.
  
  
  RESULTS
  The patient was treated with anti-CD20 monoclonal antibody and is in complete remission.
  
  
  CONCLUSIONS
  This is the first report of a patient with RTS treated for osteosarcoma in whom a SMN developed. Potential factors involved in this SMN include genetic predisposition and previous chemotherapy.
authors.affiliation: New York Medical College, Valhalla, USA.
authors.forename: C
authors.initials: C
authors.lastname: Spurney
authors.forename: R
authors.initials: R
authors.lastname: Gorlick
authors.forename: P A
authors.initials: PA
authors.lastname: Meyers
authors.forename: J H
authors.initials: JH
authors.lastname: Healey
authors.forename: A G
authors.initials: AG
authors.lastname: Huvos
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use; D018951:Antigens, CD20 / Q000276:immunology; D001859:Bone Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D016609:Neoplasms, Second Primary; D012516:Osteosarcoma / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D011038:Rothmund-Thomson Syndrome
chemical_list: D000911:Antibodies, Monoclonal; D018951:Antigens, CD20