[A study on polycyclic aromatic hydrocarbon-DNA adduct in lung cancer patients exposed to indoor coal-burning smoke].
The objective of this study is to explore the etiology and early risk evaluation of lung cancer in Xuanwei County, Yunnan Province of China. Polycyclic aromatic hydrocarbon (PAH)-DNA adduct in brushing cells from fibrobronchoscopy was determined in 30 cases with lung cancer in Xuanwei County and 10 controls in Kunming, Yunnan Province by 32P-postlabelling assay. Results showed that PAH-DNA levels in lung cancer patients of Xuanwei County were much more higher than those in controls. It suggested that air pollution caused by indoor coal-burning associated directly with the occurrence of lung cancer, and detection of DNA adduct could be used as an indicator for its risk assessment in population.
Xu
K
K
Institute of Environmental Health and Engineering, Chinese Academy of Preventive Medicine, Beijing.
Li
X
X
Hu
F
F
D016902:Air Pollution, Indoor / Q000009:adverse effects*; D001999:Bronchoscopy; D003031:Coal; D018736:DNA Adducts / Q000032:analysis*; D006801:Humans; D008175:Lung Neoplasms / Q000737:chemistry*; D011084:Polycyclic Aromatic Hydrocarbons / Q000032:analysis*; D012906:Smoke / Q000009:adverse effects
D003031:Coal; D018736:DNA Adducts; D011084:Polycyclic Aromatic Hydrocarbons; D012906:Smoke; C095911:polycyclic aromatic hydrocarbons-DNA adduct