title: [Malignant lymphoma occurring in a patient with neurofibromatosis type 1 (von Recklinghausen disease)].
abstract: Malignant lymphoma developed in a 65-year-old man with type 1 neurofibromatosis (von Recklinghausen disease). The patient visited the hospital for evaluation of generalized lymphadenopathy. A physical examination discovered café au lait spots, neurofibromas, and generalized enlargement of the superficial lymph nodes. A computed tomogram demonstrated enlarged mediastinal and para-aortic lymph nodes in the abdomen. Biopsy specimens from the right side of the patient's neck were examined, and a diagnosis of non-Hodgkin's lymphoma (diffuse mixed type, T cell type) was made. Although the patient achieved a partial response with combination chemotherapy, he died of pneumonia. Cases of malignant lymphoma associated with type 1 neurofibromatosis are rare in the literature.
authors.affiliation: Department of Internal Medicine, Miki City Hospital.
authors.forename: T
authors.initials: T
authors.lastname: Itoh
authors.forename: T
authors.initials: T
authors.lastname: Tamegane
authors.forename: Y
authors.initials: Y
authors.lastname: Ohmae
authors.forename: S
authors.initials: S
authors.lastname: Nakayama
mesh_terms: D000368:Aged; D017809:Fatal Outcome; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000209:etiology* / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000209:etiology* / Q000473:pathology; D008297:Male; D009456:Neurofibromatosis 1 / Q000150:complications* / Q000473:pathology