Effect of phencyclidine on dog coronary artery.
OBJECTIVE
To study the effect of phencyclidine (Phe) on dog coronary artery.


METHODS
Contraction of spiral strips of dog coronary artery in bioassay and coronary artery blood flow (CBF) using electromagnetic flowmeter on anesthetized dogs were observed.


RESULTS
Phe 0.1-100 mumol.L-1 induced contraction of strips in a concentration-dependent manner. Dextromethorphan (Dex) 10 mumol.L-1, an antagonist of Phe receptor, antagonized the action of Phe. In vivo, Phe 10 mg.kg-1 increased flow of left circumflex coronary artery of anesthetized dogs from 334 +/- 35 mL.kg-1.min-1 to 510 +/- 58 mL.kg-1.min-1, and both left ventrical pressure (LVP) and blood pressure (BP) rose slowly after medication. Dextromethorphan (Dex) 5 mg.kg-1 also antagonized the effect of Phe.


CONCLUSIONS
The regulation of Phe on coronary artery in vivo differs from that in vitro, which may result in the contradictory effects.
Shi
G G
GG
State Key Laboratory of Medical Neurobiology, Shanghai Medical University, China.
Wei
D S
DS
Liu
B J
BJ
Xu
S F
SF
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects*; D003331:Coronary Vessels / Q000187:drug effects; D003915:Dextromethorphan / Q000494:pharmacology; D004285:Dogs; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D010622:Phencyclidine / Q000494:pharmacology*; D017478:Receptors, Phencyclidine / Q000037:antagonists & inhibitors
D018691:Excitatory Amino Acid Antagonists; D017478:Receptors, Phencyclidine; D003915:Dextromethorphan; D010622:Phencyclidine