title: [Influence of genetic variation at apoprotein A-1 gene promoter region on plasma lipid levels in heart transplantation patients].
abstract: BACKGROUND
  To study if the presence of the G/A polymorphism at the apo A-I gene promoter region could determine the lipid profile in patients with hyperlipidemia after heart transplantation, or if it is related with the type of heart disease that determined the transplantation.
  
  
  METHODS
  This study included 31 patients with hyperlipidemia after heart transplantation. Anthropometric parameters, basic analytic and lipid study were measured in these subjects. Identification of the G/A mutation in the promoter region of the apo A-I gene was performed.
  
  
  RESULTS
  22 patients had the G/G genotype and 9 the G/A. 14 were transplanted by coronary heart disease and 17 by non ischemic heart disease. Patients with the A allele had higher cHDL (63 [SD 15] vs 53 [10]; p = 0.034) and apo A-I plasma levels (156 [34] vs 132 [24]; p = 0.040) than G/G subjects. The A allele was present in the 18% of the patients transplanted by ischemic heart disease and in the 43% of the transplanted by another etiology (p = 0.073).
  
  
  CONCLUSIONS
  The presence of the G/A genotype in the promoter region of the apo A-I gene determines higher plasma levels of cHDL in patients with hyperlipidemia after heart transplantation.
authors.affiliation: Unidad de Lípidos y Arteriosclerosis, Hospital Universitario Reina Sofía, Córdoba.
authors.forename: A
authors.initials: A
authors.lastname: González Amieva
authors.forename: J L
authors.initials: JL
authors.lastname: Zambrana
authors.forename: A
authors.initials: A
authors.lastname: López-Granados
authors.forename: M
authors.initials: M
authors.lastname: Concha
authors.forename: J
authors.initials: J
authors.lastname: López Miranda
authors.forename: A
authors.initials: A
authors.lastname: Blanco Molina
authors.forename: J A
authors.initials: JA
authors.lastname: Jiménez Perepérez
authors.forename: F
authors.initials: F
authors.lastname: Pérez Jiménez
mesh_terms: D000328:Adult; D000483:Alleles; D016632:Apolipoprotein A-I / Q000235:genetics*; D005260:Female; D005838:Genotype; D016027:Heart Transplantation; D006801:Humans; D006949:Hyperlipidemias / Q000175:diagnosis; D016014:Linear Models; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic
chemical_list: D016632:Apolipoprotein A-I; D008055:Lipids