Ability of azithromycin in combination with quinine for the elimination of babesial infection in humans.
We report the ability of azithromycin in combination with quinine to eliminate the Babesia infection in a native Taiwanese woman. Failure of elimination of the babesial infection was observed two weeks after treating with standard regimen of oral quinine plus intravenous clindamycin for a 10-day course of therapy. Azithromycin in place of clindamycin was administered for another 10-day course of therapy two months following initial treatment. Clearance of Babesia parasites was observed and verified by hamster inoculation. These results suggest that azithromycin plus quinine should be considered as an alternative therapy for human babesiosis, especially in the failure of treatment with standard regimens.
Shih
C M
CM
Department of Parasitology and Tropical Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Wang
C C
CC
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D017963:Azithromycin / Q000008:administration & dosage*; D001404:Babesiosis / Q000188:drug therapy*; D006224:Cricetinae; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008647:Mesocricetus; D008875:Middle Aged; D011803:Quinine / Q000008:administration & dosage*
D000900:Anti-Bacterial Agents; D017963:Azithromycin; D011803:Quinine