title: [Impaired kidney function in lithium therapy].
abstract: Long-term therapy with lithium may be associated with a broad spectrum of functional and structural side-effects in the kidney. Among these features, nephrogenic diabetes insipidus is the most frequent and it can be expected to occur in 20-70% of the patients. Diabetes insipidus is the result of a lithium induced resistance of collecting ducts to antidiuretic hormone. Additional functional disturbances are represented by renal tubular acidosis and consequences of hypercalcemia. Structural alterations of the kidney have a rare occurrence. In the literature, there are accounts of chronic tubulo-interstitial nephritis, acute tubular necrosis and few cases of glomerulopathies. Our report of a patient with chronic interstital nephritis is supplemented by a brief discussion of the diverse picture of the nephrotoxicity of lithium.
authors.affiliation: Departement Innere Medizin, Inselspital Bern.
authors.forename: L
authors.initials: L
authors.lastname: Gabutti
authors.forename: M
authors.initials: M
authors.lastname: Gugger
authors.forename: H P
authors.initials: HP
authors.lastname: Marti
mesh_terms: D018692:Antimanic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001706:Biopsy; D001714:Bipolar Disorder / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000139:chemically induced* / Q000473:pathology; D016651:Lithium Carbonate / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000473:pathology
chemical_list: D018692:Antimanic Agents; D016651:Lithium Carbonate