[A study on the genetic epidemiology of congenital heart disease].
In order to explore the genetic model of congenital heart disease (CHD), 375 individuals of CHD were investigated. The results showed that the incidence of primary relatives was 6.9%, the heritability was 66.13 +/- 1.13%, the incidence of secondary relatives was 1.7% and the heritability was 38.25 +/- 8.3% respectively. The average heritability among primary, secondary relatives was 65.65 +/- 1.09% which suggested that the genetic factor played an important role in pathogenesis. The sequence of the incidence in the relatives showed: primary relatives (6.9%) > secondary relatives (1.7%) > distant relatives (0.86%) and was in accordance with polygenic incidence, suqqesting that gene play an important role in the liability variation of CHD.
Liu
C Y
CY
Department of Pediatrics, Affiliated Hospital, Weifang Medical College, Shandong.
Tong
X H
XH
Du
Y H
YH
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D004374:Ductus Arteriosus, Patent / Q000453:epidemiology / Q000235:genetics; D005192:Family Health; D005260:Female; D006330:Heart Defects, Congenital / Q000453:epidemiology* / Q000235:genetics*; D006344:Heart Septal Defects, Atrial / Q000453:epidemiology / Q000235:genetics; D006345:Heart Septal Defects, Ventricular / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male