Integrins take partners: cross-talk between integrins and other membrane receptors.
This review discusses an emerging theme in the understanding of how an integrin contributes to the life of a cell. Previously, integrins have been thought to 'go it alone', but it is now appreciated that their duties extend beyond that of being 'sticky' receptors. By interacting in cis with other receptors on the cell membrane, integrins and their partner receptors inteact to form distinct membrane complexes that recruit signalling molecules to each receptor's mutual benefit. Here, Joanna Porter and Nancy Hogg discuss a few of the best characterized of these specialist integrin partnerships.
Porter
J C
JC
Leukocyte Adhesion Laboratory, Imperial Cancer Research Fund, London, UK. porterj@icrf.icnet.uk
Hogg
N
N
D015703:Antigens, CD / Q000502:physiology; D051928:CD47 Antigen; D002352:Carrier Proteins / Q000502:physiology; D051242:Caveolin 1; D022461:Caveolins; D027261:Fusion Regulatory Protein-1; D017261:Glycosylphosphatidylinositols / Q000502:physiology; D006801:Humans; D016023:Integrins / Q000502:physiology*; D016177:Macrophage-1 Antigen / Q000502:physiology; D008565:Membrane Proteins / Q000502:physiology; D008871:Microvilli / Q000378:metabolism; D005810:Multigene Family; D017395:Plasminogen Activator Inhibitor 1 / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology*; D017978:Receptors, Growth Factor / Q000502:physiology; D055293:Receptors, Urokinase Plasminogen Activator; D015398:Signal Transduction / Q000502:physiology*
D015703:Antigens, CD; D051928:CD47 Antigen; C497894:CD47 protein, human; D002352:Carrier Proteins; D051242:Caveolin 1; D022461:Caveolins; D027261:Fusion Regulatory Protein-1; D017261:Glycosylphosphatidylinositols; D016023:Integrins; D016177:Macrophage-1 Antigen; D008565:Membrane Proteins; C524898:PLAUR protein, human; D017395:Plasminogen Activator Inhibitor 1; D011956:Receptors, Cell Surface; D017978:Receptors, Growth Factor; D055293:Receptors, Urokinase Plasminogen Activator