title: Sudden death in two patients with epilepsy and the syndrome of inappropriate antidiuretic hormone secretion (SIADH).
abstract: We report two cases with complex partial and secondarily generalized seizures, both on oxcarbazepine and vigabatrin, with additional lamotrigine in one case. Both died in a manner resembling SUDEP, i.e. suddenly, unexpectedly, probably following a seizure with pulmonary oedema at autopsy. Both had SIADH. A number of drugs may cause SIADH, among them carbamazepine and oxcarbazepine. A search for SIADH in patients on carbamazepine and oxcarbazepine, and in cases of sudden death in epilepsy, is recommended.
authors.affiliation: The National Center for Epilepsy, Sandvika, Norway.
authors.forename: R
authors.initials: R
authors.lastname: Kloster
authors.forename: H C
authors.initials: HC
authors.lastname: Børresen
authors.forename: P
authors.initials: P
authors.lastname: Hoff-Olsen
mesh_terms: D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects; D001344:Autopsy; D002220:Carbamazepine / Q000009:adverse effects / Q000031:analogs & derivatives; D003645:Death, Sudden / Q000473:pathology; D004827:Epilepsy / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000209:etiology*; D000077213:Lamotrigine; D008297:Male; D008875:Middle Aged; D000078330:Oxcarbazepine; D011654:Pulmonary Edema / Q000209:etiology*; D014227:Triazines / Q000009:adverse effects; D020888:Vigabatrin; D005680:gamma-Aminobutyric Acid / Q000009:adverse effects / Q000031:analogs & derivatives
chemical_list: D000927:Anticonvulsants; D014227:Triazines; D002220:Carbamazepine; D005680:gamma-Aminobutyric Acid; D020888:Vigabatrin; D000077213:Lamotrigine; D000078330:Oxcarbazepine