title: An S100 negative granular cell tumor with malignant potential: report of a case.
abstract: Malignant granular cell tumors are rare, but exhibit typical histologic, immunohistochemical, and electron microscopic features that also characterize their benign counterparts. Although most granular cell tumors are S100 protein positive, we report an S100 negative granular cell tumor with histopathologic evidence supporting malignancy. This tumor is best categorized as a malignant granular cell tumor rather than a granular cell variant of a malignant histiocytic, mesenchymal, or epithelial neoplasm. A multidisciplinary approach is essential to diagnosis.
authors.affiliation: Department of Pathology University of Pittsburgh Medical Center, Pennsylvania, USA.
authors.forename: K E
authors.initials: KE
authors.lastname: Schoedel
authors.forename: S
authors.initials: S
authors.lastname: Bastacky
authors.forename: A
authors.initials: A
authors.lastname: Silverman
mesh_terms: D002466:Cell Nucleolus / Q000648:ultrastructure; D002467:Cell Nucleus / Q000648:ultrastructure; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D003593:Cytoplasm / Q000648:ultrastructure; D003937:Diagnosis, Differential; D016586:Granular Cell Tumor / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008247:Lysosomes / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis*; D012535:Scalp / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*; D014746:Vimentin / Q000032:analysis
chemical_list: D009418:S100 Proteins; D014746:Vimentin; D010751:Phosphopyruvate Hydratase