[The relationship between viral hepatitis and primary liver cancer in four areas of China].
To investigate the relationship between hepatitis B, C and G and primary liver cancer (PLC), both population-based and hospital-based case-control studies were conducted in four areas of China. The prevlence rates of HBsAg in 359 pairs of PLC cases and controls were 66.3% and 23.4% (OR = 6.60, PAR = 55.5%), respectively; the prevalence of anti-HCV in 340 pairs of PLC cases and controls were 17.9% and 6.5% (OR = 3.31, PAR = 12.4%), respectively. When both markers were positive, the OR was higher than their multiple effect of HBsAg and anti-HCV. In the Haimen Case-control study, serum HGV-RNA was detected in 11 of the 50 PLC cases, compared to 5 of the 50 controls matched with age and sex (P > 0.05). These data suggested that HBV might have played a more important role than HCV and HGV in the development of PLC in China.
Yu
S Z
SZ
Insitute of Preventive Medicine, Shanghai Medical University.
Zi
X L
XL
Chen
G
G
D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D018067:Flaviviridae; D006509:Hepatitis B / Q000150:complications / Q000453:epidemiology*; D006526:Hepatitis C / Q000150:complications / Q000453:epidemiology*; D006525:Hepatitis, Viral, Human / Q000150:complications / Q000453:epidemiology; D006801:Humans; D008113:Liver Neoplasms / Q000453:epidemiology* / Q000209:etiology; D008297:Male; D015995:Prevalence; D012307:Risk Factors