title: The role of neuronal nicotinic acetylcholine receptors in antinociception: effects of ABT-594.
abstract: ABT-594, a nicotinic acetylcholine receptor agonist, has antinociceptive effects in rat models of acute thermal, persistent chemical, and neuropathic pain. Direct injection of ABT-594 into the nucleus raphe magnus (NRM) is antinociceptive in a thermal threshold test and destruction of serotonergic neurons in the NRM attenuates the effect of systemic ABT-594. However, lidocaine-inactivation of the NRM prevents the antinociceptive effect of systemic (-)-nicotine but not that of systemic ABT-594.
authors.affiliation: Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, IL 60064-3500, USA.
authors.forename: M W
authors.initials: MW
authors.lastname: Decker
authors.forename: P
authors.initials: P
authors.lastname: Curzon
authors.forename: M W
authors.initials: MW
authors.lastname: Holladay
authors.forename: A L
authors.initials: AL
authors.lastname: Nikkel
authors.forename: R S
authors.initials: RS
authors.lastname: Bitner
authors.forename: A W
authors.initials: AW
authors.lastname: Bannon
authors.forename: D L
authors.initials: DL
authors.lastname: Donnelly-Roberts
authors.forename: P S
authors.initials: PS
authors.lastname: Puttfarcken
authors.forename: T A
authors.initials: TA
authors.lastname: Kuntzweiler
authors.forename: C A
authors.initials: CA
authors.lastname: Briggs
authors.forename: M
authors.initials: M
authors.lastname: Williams
authors.forename: S P
authors.initials: SP
authors.lastname: Arneric
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D001384:Azetidines / Q000494:pharmacology*; D004195:Disease Models, Animal; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D018722:Nicotinic Agonists / Q000494:pharmacology*; D010146:Pain / Q000188:drug therapy* / Q000503:physiopathology; D011725:Pyridines / Q000494:pharmacology*; D011903:Raphe Nuclei / Q000187:drug effects; D051381:Rats; D011978:Receptors, Nicotinic / Q000502:physiology*
chemical_list: C109763:5-(2-azetidinylmethoxy)-2-chloropyridine; D018712:Analgesics, Non-Narcotic; D001384:Azetidines; D018722:Nicotinic Agonists; D011725:Pyridines; D011978:Receptors, Nicotinic