Mapping of human interferon regulatory factor 3 (IRF3) to chromosome 19q13.3-13.4 by an intragenic polymorphic marker.
We have identified a highly polymorphic intragenic marker composed of two dinucleotide repeats in an intron of the human interferon regulatory factor (IRF3) gene. This polymorphic marker has allowed us to map IRF3 to the boundary of 19q13.3-13.4 between the polymorphic markers D19S604 and D19S206 close to KLK1. An intron is present in a homologous position in the mouse Irf3 gene, but lacks the dinucleotide repeats present in the human intron. Syntenic conservation between this region of 19q13.3-13.4 maps Irf3 to either mouse chromosome 7 or 17.
Bellingham
J
J
Department of Molecular Genetics, Imperial College School of Medicine, London, UK. jbelling@hgmp.mrc.ac.uk
Gregory-Evans
K
K
Gregory-Evans
C Y
CY
D000483:Alleles; D000595:Amino Acid Sequence; D001483:Base Sequence; D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D018076:DNA, Complementary; D004268:DNA-Binding Proteins / Q000235:genetics*; D005787:Gene Frequency; D005819:Genetic Markers; D006801:Humans; D050838:Interferon Regulatory Factor-3; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D014157:Transcription Factors / Q000235:genetics*
D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D005819:Genetic Markers; C494232:IRF3 protein, human; D050838:Interferon Regulatory Factor-3; D014157:Transcription Factors