title: Familial sick sinus syndrome with atrioventricular conduction disturbance.
abstract: A family with sick sinus syndrome is presented: a mother and her 2 daughters affected with sinus node dysfunction. Electrophysiological studies revealed abnormal atrioventricular conduction in the 2 daughters. All 3 individuals were implanted with a permanent pacemaker to relieve their symptoms. Endomyocardial biopsy from the right ventricle of one daughter showed disarrangement, degeneration, myocyte necrosis and interstitial fibrosis suggestive of myocardial disease.
authors.affiliation: First Department of Internal Medicine, Shinshu University, School of Medicine, Matsumoto, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Isobe
authors.forename: T
authors.initials: T
authors.lastname: Oka
authors.forename: H
authors.initials: H
authors.lastname: Takenaka
authors.forename: H
authors.initials: H
authors.lastname: Imamura
authors.forename: O
authors.initials: O
authors.lastname: Kinoshita
authors.forename: H
authors.initials: H
authors.lastname: Kasanuki
authors.forename: M
authors.initials: M
authors.lastname: Sekiguchi
mesh_terms: D000328:Adult; D002648:Child; D005190:Family; D005260:Female; D020022:Genetic Predisposition to Disease; D006327:Heart Block; D006801:Humans; D008875:Middle Aged; D010138:Pacemaker, Artificial; D012804:Sick Sinus Syndrome / Q000235:genetics* / Q000503:physiopathology* / Q000628:therapy