Biopharmaceutical availability of sulphadicramide from ocular ointments in vitro.
The effect of absorption promoters, i.e. sodium deoxycholate, lauryl ether polioxyethylene-9, and l-alpha-lysophosphatidylo choline, on the process of sulphadicramide dialysis through lipophilic synthetic membranes and animal cornea in vitro, was studied. Formulation of ophthalmic ointments containing sulphadicramide and the above promoters was proposed and biopharmaceutical evaluation of the ointments was performed.
Grześkowiak
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Department of Physical Chemistry, K. Marcinkowski University of Medical Sciences, Poznań, Poland. grzesko@eucalyptus.usoms.poznan.pl
D000577:Amides / Q000493:pharmacokinetics*; D000818:Animals; D001682:Biological Availability; D003315:Cornea / Q000378:metabolism*; D066298:In Vitro Techniques; D009824:Ointments; D010539:Permeability; D013552:Swine
D000577:Amides; D009824:Ointments; C116461:sulphadicramide