title: 2-Amino-2-oxazolines, Part 9: Synthesis and pharmacological evaluation of N-phenyl-N'-[1-[3-(1-aryl-4-piperazinyl)propan-2-ol]]ureas.
abstract: N-Phenyl-N'-[1-[3-(1-aryl-4-piperazinyl)propan-2-ol]]ureas (3) were synthesized from the 3-phenylcarbamoyl-5-[(1-aryl-4-piperazinyl)methyl]-2-iminooxazolidine s (1) via the corresponding 2-oxazolidinones (2). The prepared compounds were screened for their antiallergic and analgesic activities.
authors.affiliation: Laboratoire de Chimie Physique, UFR des Sciences Pharmaceutiques, Université Victor Segalen Bordeaux, France.
authors.forename: J J
authors.initials: JJ
authors.lastname: Bosc
authors.forename: C
authors.initials: C
authors.lastname: Jarry
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D018926:Anti-Allergic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006168:Guinea Pigs; D006633:Histamine Antagonists / Q000494:pharmacology; D010147:Pain Measurement / Q000187:drug effects; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D014508:Urea / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000700:Analgesics; D018926:Anti-Allergic Agents; D006633:Histamine Antagonists; D014508:Urea