Liver and renal function after repeated sevoflurane or isoflurane anaesthesia.
OBJECTIVE
To compare retrospectively liver and renal function after repeated exposure (twice) to sevoflurane or isoflurane.


METHODS
Sixty patients were studied for liver and renal function after repeated exposure within 30 to 180 days to sevoflurane (30 patients) or isoflurane (30 patients). Serum concentrations of aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (TBil), alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GTP), blood urea nitrogen (BUN) and creatinine (Cr) were measured before and, 1, 3, 7, and 14 days after surgery. Qualitative analyses of urinary protein and glucose were done 1, 3, and 7 days after surgery.


RESULTS
The number of patients with abnormal values in AST, ALT and GTP was larger in the isoflurane than in the sevoflurane group. BUN and Cr were within normal range after anaesthesia in either group. Renal excretion of protein and glucose increased one and three days after anaesthesia with no difference between the anaesthetics. None of the variables showed differences between the first and second anaesthesia after either anaesthetic.


CONCLUSIONS
Repeat exposure to sevoflurane or isoflurane within 30 to 180 days had no additional risk of increasing serum concentration of liver enzymes or increasing urinary excretion of protein and glucose compared with the first exposure to the same anaesthetic.
Nishiyama
T
T
Department of Anesthesiology, University of Tokyo.
Yokoyama
T
T
Hanaoka
K
K
D000368:Aged; D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D002118:Calcium / Q000378:metabolism; D005260:Female; D006801:Humans; D007530:Isoflurane / Q000009:adverse effects*; D007668:Kidney / Q000187:drug effects*; D008099:Liver / Q000187:drug effects*; D008297:Male; D008738:Methyl Ethers / Q000009:adverse effects*; D008875:Middle Aged; D000077149:Sevoflurane
D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane; D007530:Isoflurane; D002118:Calcium