Genital variant of folliculosebaceous cystic hamartoma.
BACKGROUND
Clinically, folliculosebaceous cystic hamartomas (FSCH) present as skin-colored papulonodules of the face, especially the nose. This is in contrast to sebaceous trichofolliculomas which often present as depressed ostia containing terminal or vellus hairs.


METHODS
A 34-year-old female had a skin-colored multinodular plaque of the labia majora that demonstrated the histologic findings of an FSCH. These included an irregularly shaped central cystic structure surrounded by multiple sebaceous lobules as well as a fibrous stroma. The epithelial-lined cyst contained no hair shafts.


CONCLUSIONS
A single case report of a scrotal lesion with a similar clinical appearance and histologic findings has previously been described as a genital variant of sebaceous trichofolliculoma. However, the report predated the initial description of FSCH. In our opinion, both cases represent examples of the genital variant of FSCH.
Bolognia
J L
JL
Department of Dermatology, Yale University, New Haven, Conn., USA. jean.bolognia@yale.edu
Longley
B J
BJ
D000328:Adult; D000368:Aged; D005260:Female; D005831:Genital Diseases, Female / Q000473:pathology; D018859:Hair Follicle / Q000473:pathology; D006222:Hamartoma / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012627:Sebaceous Glands / Q000473:pathology; D012871:Skin Diseases / Q000473:pathology*; D014844:Vulva / Q000473:pathology*