title: Reactive oxygen species: their relation to pneumoconiosis and carcinogenesis.
abstract: Occupational exposures to mineral particles cause pneumoconiosis and other diseases, including cancer. Recent studies have suggested that reactive oxygen species (ROS) may play a key role in the mechanisms of disease initiation and progression following exposure to these particles. ROS-induced primary stimuli result in the increased secretion of proinflammatory cytokines and other mediators, promoting events that appear to be important in the progression of cell injury and pulmonary disease. We have provided evidence supporting the hypothesis that inhalation of insoluble particles such as asbestos, agricultural dusts, coal, crystalline silica, and inorganic dust can be involved in facilitating multiple pathways for persistent generation of ROS, which may lead to a continuum of inflammation leading to progression of disease. This article briefly summarizes some of the recent findings from our laboratories with emphasis on the molecular events by which ROS are involved in promoting pneumoconiosis and carcinogenesis.
authors.affiliation: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. vav1@cdc.gov
authors.forename: V
authors.initials: V
authors.lastname: Vallyathan
authors.forename: X
authors.initials: X
authors.lastname: Shi
authors.forename: V
authors.initials: V
authors.lastname: Castranova
mesh_terms: D000818:Animals; D004249:DNA Damage; D016158:Genes, p53; D006801:Humans; D015227:Lipid Peroxidation; D008168:Lung / Q000378:metabolism; D055370:Lung Injury; D008175:Lung Neoplasms / Q000209:etiology* / Q000235:genetics / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism; D011009:Pneumoconiosis / Q000209:etiology* / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism*; D018808:Transcription Factor AP-1 / Q000378:metabolism
chemical_list: D016328:NF-kappa B; D017382:Reactive Oxygen Species; D018808:Transcription Factor AP-1