title: Antiallergic agent from natural sources. Structures and inhibitory effect of histamine release of naphthopyrone glycosides from seeds of Cassia obtusifolia L.
abstract: Two new naphthopyrones, cassiasides B2 (1) and C2 (2), were isolated from the seeds (Cassiae Semen) of Cassia obtusifolia L. The structures of the two new compounds 1 and 2 were established as rubrofusarin 6-O-beta-D- glucopyranosyl-(1-->6)-O-beta-D-glucopyranosyl-(1-->3)-O-beta-D- glucopyranosyl-(1-->6)-O-beta-D-glucopyranoside and toralactone 9-O-beta-D-glucopyranosyl-(1-->6)-O-beta-D-glucopyranosyl- (1-->3)-O-beta-D-glucopyranosyl-(1-->6)-O-beta-D-glucopyranoside, respectively, on the basis of spectral and chemical evidence. Compound 2 was found to inhibit the histamine release from rat peritoneal exudate mast cells induced by antigen-antibody reaction.
authors.affiliation: College of Pharmacy, Nihon University, Chiba, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kitanaka
authors.forename: T
authors.initials: T
authors.lastname: Nakayama
authors.forename: T
authors.initials: T
authors.lastname: Shibano
authors.forename: E
authors.initials: E
authors.lastname: Ohkoshi
authors.forename: M
authors.initials: M
authors.lastname: Takido
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000032:analysis*; D000937:Antigen-Antibody Reactions; D002240:Carbohydrate Sequence; D002366:Cassia / Q000737:chemistry*; D005122:Exudates and Transudates / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D006636:Histamine Release / Q000187:drug effects*; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008407:Mast Cells / Q000187:drug effects; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal; D011753:Pyrones / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D012639:Seeds / Q000737:chemistry
chemical_list: D018926:Anti-Allergic Agents; D009844:Oligosaccharides; D011753:Pyrones; C115839:rubrofusarin 6-O-glucopyranosyl-(1-6)-O-glucopyranosyl-(1-3)-O-glucopyranosyl-(1-6)-O-glucopyranoside; C115840:toralactone 9-O-glucopyranosyl-(1-6)-O-glucopyran osyl-(1-3)-O-glucopyranosyl-(1-6)-O-glucopyranoside