title: Attentional improvement following quetiapine fumarate treatment in schizophrenia.
abstract: This study examined changes in attentional performance in patients with schizophrenia during the 2 months after initiating treatment with quetiapine fumarate. Prior to treatment, attentional performance in patients with schizophrenia (n = 10) was significantly (p < 0.01) worse than in matched controls (n = 12). During treatment with quetiapine, performance in patients with schizophrenia improved, and by 2 months, did not differ significantly from that of the controls. These results suggest that quetiapine produces a significant improvement in attentional functioning in patients with schizophrenia.
authors.affiliation: Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267-0559, USA. saxkw@email.uc.edu
authors.forename: K W
authors.initials: KW
authors.lastname: Sax
authors.forename: S M
authors.initials: SM
authors.lastname: Strakowski
authors.forename: P E
authors.initials: PE
authors.lastname: Keck
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001288:Attention / Q000187:drug effects*; D003987:Dibenzothiazepines / Q000009:adverse effects / Q000627:therapeutic use*; D004193:Discrimination Learning / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D011597:Psychomotor Performance / Q000187:drug effects; D000069348:Quetiapine Fumarate; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D000069348:Quetiapine Fumarate