title: Clinical consequences of the use of highly purified silicone oil. Comparative study of highly and less purified silicone oil.
abstract: OBJECTIVE
  To compare the ocular toxicity caused by the use of highly purified silicone oil to less purified silicone oil in humans.
  
  
  METHODS
  Fifty-six eyes received 2,000 centistokes (cs) purified silicone oil (group 1) and 42 eyes received 2,000 cs fractionated (highly purified) silicone oil (group 2) after pars plana vitrectormy. Follow-up ranged from 6 to 48 months.
  
  
  RESULTS
  Six months after injection, the following complications were found in groups 1 and 2, respectively: ocular hypotension (< 13 mmHg), 39.3% and 31%, sustained ocular hypertension (> 23 mmHg), 19.6% and 19%; acute hypertensive peaks (> 30 mmHg), 23.2% and 11.9%; corneal alterations, 19.6% and 14.3%; emulsification, 1.8% and 2.4%; silicone oil cloudiness, 28.6% and 0%; preretinal reproliferation, 14.3% and 4.8% and total or partial retinal reattachment, 78.6% and 90.5%.
  
  
  CONCLUSIONS
  Highly purified silicone oil was better tolerated than the less purified oil and caused fewer complications. Poorly purified silicone oils should be avoided in clinical practice.
authors.affiliation: Vitreoretina Unit, Universidad de Valladolid, Spain.
authors.forename: J C
authors.initials: JC
authors.lastname: Pastor
authors.forename: J M
authors.initials: JM
authors.lastname: Zarco
authors.forename: M J
authors.initials: MJ
authors.lastname: Del Nozal
authors.forename: A
authors.initials: A
authors.lastname: Pampliega
authors.forename: P
authors.initials: P
authors.lastname: Marinero
mesh_terms: D000368:Aged; D003316:Corneal Diseases / Q000139:chemically induced; D005500:Follow-Up Studies; D006801:Humans; D007267:Injections; D008875:Middle Aged; D009798:Ocular Hypertension / Q000139:chemically induced; D011183:Postoperative Complications / Q000139:chemically induced*; D012008:Recurrence; D012163:Retinal Detachment / Q000139:chemically induced / Q000209:etiology / Q000601:surgery; D012189:Retrospective Studies; D012827:Silicone Oils / Q000008:administration & dosage / Q000009:adverse effects*; D014783:Viscosity; D014821:Vitrectomy; D018630:Vitreoretinopathy, Proliferative / Q000150:complications / Q000601:surgery
chemical_list: D012827:Silicone Oils