[Follow-up of collagen and bone metabolism in patients with cement-free total hip endoprosthesis].
BACKGROUND
This study investigated the influence of concentration and activity of several markers of the collagen and bone metabolism and their impact on ingrowth of non-cemented total hip arthroplasty.


METHODS
40 patients underwent an implantation of a ABG-prosthesis. Before surgery and 1, 2, 12 and 24 weeks after it serum concentrations of PICP, ICTP, IGF-1, ON, b-AP, Calcium, Phosphate, GPT and Creatinin were measured and a collagen ratio (CQ) was calculated.


RESULTS
PICP decreased until 1st week, increased at 2nd week and decreased again after that time. ICTP increased significantly in 1st week, reached a maximum in 2nd week and decreased after that. b-AP decreased in 1st week but increased after that time. IGF-1 and ON decreased significantly after surgery but increased later. Calcium and Phosphate always showed normal values. CQ decreased in 1st week in males (45%) and females (60%), but increased later on.


CONCLUSIONS
These markers investigated made it possible to estimate the osteointegration of non-cemented total hip arthroplasty and confirm radiologic and histomorphometric results of the literature.
Meurer
A
A
Orthopädische Klinik und Poliklinik der Universität Mainz.
Lotz
J
J
Giesa
M
M
Eckardt
A
A
Prellwitz
W
W
Heine
J
J
D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D019644:Arthroplasty, Replacement, Hip; D015415:Biomarkers / Q000097:blood; D001843:Bone Cements; D015519:Bone Density / Q000502:physiology*; D001842:Bone and Bones / Q000201:enzymology*; D003094:Collagen / Q000097:blood*; D005260:Female; D005271:Femur Head Necrosis / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016348:Osseointegration / Q000502:physiology; D015207:Osteoarthritis, Hip / Q000601:surgery; D010446:Peptide Fragments / Q000097:blood; D011183:Postoperative Complications / Q000175:diagnosis* / Q000201:enzymology; D011347:Procollagen / Q000097:blood; D012016:Reference Values
D015415:Biomarkers; D001843:Bone Cements; D010446:Peptide Fragments; D011347:Procollagen; C042813:procollagen type I carboxy terminal peptide; D003094:Collagen; D000469:Alkaline Phosphatase