B-cell development: a comparison between mouse and man.
A common variable immunodeficiency (CVID) patient, who carries mutations on both alleles of the gene encoding the surrogate light chain component lambda 5/14.1, shows a similar phenotype of B-cell deficiency as the lambda 5-deficient mutant mouse. As discussed here by Paolo Ghia and colleagues, this points to a remarkably similar developmental pathway of B cells in humans and mice.
Ghia
P
P
Dana Farber Cancer Institute Boston, MA, USA.
ten Boekel
E
E
Rolink
A G
AG
Melchers
F
F
D000367:Age Factors; D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology* / Q000276:immunology; D002454:Cell Differentiation; D002642:Chick Embryo; D017074:Common Variable Immunodeficiency / Q000276:immunology; D015328:Gene Rearrangement, B-Lymphocyte, Light Chain / Q000276:immunology; D006801:Humans; D051379:Mice; D010641:Phenotype