Kaposi's sarcoma in a patient with erythroblastopenia and thymoma: reactivation after topical corticosteroids.
We report a 69-year-old female with erythroblastopenia and thymoma who developed lesions of Kaposi's sarcoma (KS) after thymectomy, 2 months after the initiation of therapy with methylprednisolone. Control of mucocutaneous KS lesions was obtained with radiotherapy, interferon alfa-2b and withdrawal of systemic immunosuppressive therapy. Erosive oral lichen planus appeared later, and after therapy with topical corticosteroids a new lesion of KS developed that regressed after withdrawal of topical corticosteroids. The detection of HHV-8 only in lesional skin supports the hypothesis that this virus can trigger the development of KS lesions.
Pérez
E
E
Department of Dermatology, Hospital de la Sta. Creu i St. Pau, Barcelona, Spain.
Barnadas
M A
MA
García-Patos
V
V
Pedro
C
C
Curell
R
R
Sander
C A
CA
Kind
P
P
de Moragas
J M
JM
Alomar
A
A
D000287:Administration, Topical; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000627:therapeutic use; D004900:Erythroblasts / Q000473:pathology*; D005260:Female; D005938:Glucocorticoids; D006801:Humans; D012514:Sarcoma, Kaposi / Q000209:etiology*; D012878:Skin Neoplasms / Q000209:etiology*; D013945:Thymoma / Q000150:complications* / Q000473:pathology; D013953:Thymus Neoplasms / Q000150:complications* / Q000473:pathology; D014221:Triamcinolone / Q000009:adverse effects / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D014221:Triamcinolone