title: Lack of R117H mutation in the cationic trypsinogen gene in patients with tropical pancreatitis from Bangladesh.
abstract: The etiology of nonalcoholic chronic pancreatitis, occurring in tropical regions, is unknown. Although environmental factors may play a role in its pathogenesis, a specific genetic predisposition may be necessary. The genetic mutation responsible for hereditary pancreatitis was described recently. Unlike in patients with hereditary pancreatitis, we found a lack of the R117H mutation in the cationic trypsinogen gene in all patients with tropical pancreatitis from Bangladesh.
authors.affiliation: Research Division, Bangladesh Institute of Research & Rehabilitation in Diabetes, Endocrine & Metabolic Disorders, Dhaka.
authors.forename: L
authors.initials: L
authors.lastname: Rossi
authors.forename: D C
authors.initials: DC
authors.lastname: Whitcomb
authors.forename: G D
authors.initials: GD
authors.lastname: Ehrlich
authors.forename: M C
authors.initials: MC
authors.lastname: Gorry
authors.forename: S
authors.initials: S
authors.lastname: Parvin
authors.forename: S
authors.initials: S
authors.lastname: Sattar
authors.forename: L
authors.initials: L
authors.lastname: Ali
authors.forename: A K
authors.initials: AK
authors.lastname: Azad Khan
authors.forename: N
authors.initials: N
authors.lastname: Gyr
mesh_terms: D000293:Adolescent; D000328:Adult; D001459:Bangladesh; D002908:Chronic Disease; D004247:DNA / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D010195:Pancreatitis / Q000235:genetics*; D017354:Point Mutation; D014329:Tropical Climate; D014362:Trypsinogen / Q000235:genetics*
chemical_list: D014362:Trypsinogen; D004247:DNA