An Escherichia coli gene responsive to heavy metals.
Using in vivo translational gene fusion in Escherichia coli K-12 we identified a gene that is specifically induced by heavy metals, cadmium, mercury and zinc, at nmolar concentrations. This gene was identified by homology to known zinc and cadmium transporters. We created a disruption of the gene that resulted only in a minor increase in sensitivity to cadmium, suggesting that the fusion, which is at the carboxy-terminal end of the molecule, probably allows for at least partial activity of the protein.
Babai
R
R
Department of Molecular Microbiology and Biotechnology, Tel-Aviv University, Israel.
Ron
E Z
EZ
D000251:Adenosine Triphosphatases / Q000235:genetics*; D019677:Artificial Gene Fusion; D002104:Cadmium / Q000378:metabolism / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics* / Q000254:growth & development; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D018869:Heat-Shock Response / Q000235:genetics; D019216:Metals, Heavy / Q000494:pharmacology*; D018384:Oxidative Stress / Q000235:genetics; D014176:Protein Biosynthesis; D001616:beta-Galactosidase / Q000378:metabolism
D019216:Metals, Heavy; D002104:Cadmium; D001616:beta-Galactosidase; D000251:Adenosine Triphosphatases; C109898:Zn(II)-translocating P-type ATPase