[Stereospecific anomalies in the structure of five completely sequenced yeast chromosomes].
Using an original computer program we analysed complete nucleotide sequences of chromosomes I, II, III, VI and IX in yeast cells. As a general rule, we found large stereospecific anomalies near genes with a presumed high expression level (a full catalogue of such anomalies for 5 genes with highest CAI in each chromosome is presented). As a rule, they are also present at mobile genetic elements. Many large stereospecific anomalies are situated next to the sites of specific anomalies of general nucleotide composition-regions devoid of specific dinucleotides. We have noticed many "trains" (lines) of different stereospecific anomalies, possibly showing areas of cooperative binding of different regulatory and structural proteins to DNA. In several, but not all, analysed chromosomes we found a new class of especially large stereospecific anomalies related to repetitive DNA of small length (less than or around 100 nucleotides).
Soĭdla
T R
TR
Institute of Cytology, Russian Academy of Sciences, St. Petersburg.
Lukina
N I
NI
D002869:Chromosome Aberrations; D015825:Chromosomes, Fungal; D016681:Genome, Fungal; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D017422:Sequence Analysis, DNA; D012984:Software