title: HLA and HPA typing in idiopathic thrombocytopenic purpura patients treated with Kami-kihi-to.
abstract: We performed human leukocyte antigen (HLA) and human platelet antigen (HPA) in patients with Kami-kihi-to-responsive idiopathic thrombocytopenic purpura. The HLA-A2, A61 and Cw1 were significantly increased in responders compared with nonresponders, as were HLA DRB1 *0901, DRB1 *1502, and DPB1 *0501. In contrast, HLA DPB1 *0201 and DPB1 *0901 were significantly decreased in responders. The a/b genotype of HPA-2 and a/a genotype of HPA-3 were markedly increased in nonresponders, and anti-GPIb antibody was also increased. These results suggest that HLA, HPA, and anti-GP antibody studies may predict the response of idiopathic thrombocytopenic purpura to Kami-kihi-to.
authors.affiliation: Department of Blood Transfusion, Kansai Medical University, Osaka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Matsuzaki
authors.forename: S
authors.initials: S
authors.lastname: Nomura
authors.forename: M
authors.initials: M
authors.lastname: Yamaoka
authors.forename: Y
authors.initials: Y
authors.lastname: Ozaki
authors.forename: C
authors.initials: C
authors.lastname: Yoshimura
authors.forename: G L
authors.initials: GL
authors.lastname: Xie
authors.forename: K
authors.initials: K
authors.lastname: Katsura
authors.forename: H
authors.initials: H
authors.lastname: Kagawa
authors.forename: T
authors.initials: T
authors.lastname: Ishida
authors.forename: S
authors.initials: S
authors.lastname: Fukuhara
mesh_terms: D016824:Antigens, Human Platelet / Q000145:classification* / Q000235:genetics; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006680:HLA Antigens / Q000145:classification* / Q000235:genetics; D015789:HLA-A2 Antigen / Q000145:classification / Q000235:genetics; D015235:HLA-B Antigens / Q000145:classification / Q000235:genetics; D015236:HLA-C Antigens / Q000145:classification / Q000235:genetics; D006684:HLA-DR Antigens / Q000145:classification / Q000235:genetics; D059811:HLA-DRB1 Chains; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000188:drug therapy / Q000276:immunology*
chemical_list: D016824:Antigens, Human Platelet; D004365:Drugs, Chinese Herbal; D006680:HLA Antigens; D015789:HLA-A2 Antigen; D015235:HLA-B Antigens; C079077:HLA-B61 antigen; D015236:HLA-C Antigens; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains