title: Gastric perforation due to mucormycosis after heart-lung and heart transplantation.
abstract: BACKGROUND
  Gastrointestinal complications are a well-documented source of morbidity and mortality after heart and lung transplantation.
  
  
  METHODS
  We report on two patients who presented with gastric perforation caused by mucormycosis during the first 2 months after heart-lung and heart transplantation.
  
  
  RESULTS
  In the first patient, the clinical presentation was insidious and the diagnosis was made at an advanced stage of the disease. Despite surgery and aggressive antifungal treatment, the patient died. In the second patient, the diagnosis was made promptly, but despite antifungal treatment, he presented with gastric perforation within a week.
  
  
  CONCLUSIONS
  These cases illustrate that fungal invasive disease may be a cause of early gastrointestinal perforation after solid organ transplantation.
authors.affiliation: Department of Chest Medicine, Erasme University Hospital, Brussels, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Knoop
authors.forename: M
authors.initials: M
authors.lastname: Antoine
authors.forename: J L
authors.initials: JL
authors.lastname: Vachiéry
authors.forename: G
authors.initials: G
authors.lastname: Depré
authors.forename: C
authors.initials: C
authors.lastname: Alonso-Vega
authors.forename: M
authors.initials: M
authors.lastname: Struelens
authors.forename: J L
authors.initials: JL
authors.lastname: Van Laethem
authors.forename: P
authors.initials: P
authors.lastname: Lingier
authors.forename: N
authors.initials: N
authors.lastname: Nagy
authors.forename: F
authors.initials: F
authors.lastname: Jacobs
authors.forename: M R
authors.initials: MR
authors.lastname: Kramer
authors.forename: M
authors.initials: M
authors.lastname: Estenne
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use; D017809:Fatal Outcome; D015774:Ganciclovir / Q000627:therapeutic use; D016027:Heart Transplantation; D016041:Heart-Lung Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000150:complications* / Q000188:drug therapy / Q000209:etiology*; D011183:Postoperative Complications; D012233:Rhizopus / Q000302:isolation & purification; D013272:Stomach Diseases / Q000382:microbiology* / Q000473:pathology
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B; D015774:Ganciclovir