Clinical consequences of the use of highly purified silicone oil. Comparative study of highly and less purified silicone oil.
OBJECTIVE
To compare the ocular toxicity caused by the use of highly purified silicone oil to less purified silicone oil in humans.


METHODS
Fifty-six eyes received 2,000 centistokes (cs) purified silicone oil (group 1) and 42 eyes received 2,000 cs fractionated (highly purified) silicone oil (group 2) after pars plana vitrectormy. Follow-up ranged from 6 to 48 months.


RESULTS
Six months after injection, the following complications were found in groups 1 and 2, respectively: ocular hypotension (< 13 mmHg), 39.3% and 31%, sustained ocular hypertension (> 23 mmHg), 19.6% and 19%; acute hypertensive peaks (> 30 mmHg), 23.2% and 11.9%; corneal alterations, 19.6% and 14.3%; emulsification, 1.8% and 2.4%; silicone oil cloudiness, 28.6% and 0%; preretinal reproliferation, 14.3% and 4.8% and total or partial retinal reattachment, 78.6% and 90.5%.


CONCLUSIONS
Highly purified silicone oil was better tolerated than the less purified oil and caused fewer complications. Poorly purified silicone oils should be avoided in clinical practice.
Pastor
J C
JC
Vitreoretina Unit, Universidad de Valladolid, Spain.
Zarco
J M
JM
Del Nozal
M J
MJ
Pampliega
A
A
Marinero
P
P
D000368:Aged; D003316:Corneal Diseases / Q000139:chemically induced; D005500:Follow-Up Studies; D006801:Humans; D007267:Injections; D008875:Middle Aged; D009798:Ocular Hypertension / Q000139:chemically induced; D011183:Postoperative Complications / Q000139:chemically induced*; D012008:Recurrence; D012163:Retinal Detachment / Q000139:chemically induced / Q000209:etiology / Q000601:surgery; D012189:Retrospective Studies; D012827:Silicone Oils / Q000008:administration & dosage / Q000009:adverse effects*; D014783:Viscosity; D014821:Vitrectomy; D018630:Vitreoretinopathy, Proliferative / Q000150:complications / Q000601:surgery
D012827:Silicone Oils