The Grb7 family of signalling proteins.
The Grb7 family is a rapidly emerging group of Src homology (SH)2 domain-containing signalling proteins that currently contains three members, Grb7, 10 and 14. These proteins possess a conserved multidomain structure, including a central region exhibiting significant homology to the Caenorhabditis elegans protein Mig10. Differences in tissue expression and SH2 binding selectivity suggest that these adaptor proteins function in a tissue-specific manner to link specific receptor tyrosine kinases (RTKs) and other tyrosine phosphorylated proteins to as yet uncharacterised downstream effectors. Interestingly, Grb7 proteins exhibit differential expression amongst a variety of human cancers and cancer cell lines. Consequently, these proteins not only are likely to perform a fundamental signalling role, but may also modulate RTK signalling in cancer cells.
Daly
R J
RJ
Cancer Research Program, The Garvan Institute of Medical Research, St. Vincent's Hospital, Sydney, NSW, Australia. r.daly@garvan.unsw.edu.au
D000595:Amino Acid Sequence; D000818:Animals; D029742:Caenorhabditis elegans Proteins; D051382:GRB7 Adaptor Protein; D015870:Gene Expression; D015801:Helminth Proteins / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000378:metabolism; D010766:Phosphorylation; D011506:Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D018909:src Homology Domains
D029742:Caenorhabditis elegans Proteins; C495955:GRB7 protein, human; D015801:Helminth Proteins; C105812:Mig-10 protein, C elegans; D011506:Proteins; D051382:GRB7 Adaptor Protein; D020794:Receptor Protein-Tyrosine Kinases