Vanadate treatment normalizes exaggerated vascular smooth muscle responses in the obese Zucker rat.
The effect of oral vanadate treatment on isometric tension responses were examined in aortic rings isolated from obese and lean Zucker rats. Rats from both strains that were either maintained on food ad libitum or pair-fed were included to serve as controls. Higher plasma insulin and glucose levels and exaggerated aortic tension responses to endothelin-1, methoxamine, and KCl observed in obese Zucker rats were normalized in vanadate treated, but not pair-fed, rats. These data suggest that abnormal vascular responses in obese Zucker rats can be normalized by vanadate treatment in a manner at least partly independent of food intake.
Hopfner
R L
RL
Department of Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, Canada.
McNeill
J R
JR
Gopalakrishnan
V
V
D000109:Acetylcholine / Q000494:pharmacology; D000284:Administration, Oral; D000818:Animals; D001011:Aorta / Q000187:drug effects; D001786:Blood Glucose; D001835:Body Weight / Q000187:drug effects; D004347:Drug Interactions; D007328:Insulin / Q000097:blood; D008729:Methoxamine / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009765:Obesity / Q000097:blood / Q000503:physiopathology*; D051381:Rats; D011924:Rats, Zucker; D013045:Species Specificity; D014638:Vanadates / Q000494:pharmacology*; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology*
D001786:Blood Glucose; D007328:Insulin; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D014638:Vanadates; D008729:Methoxamine; D000109:Acetylcholine