title: Mechanism of action of beta2-glycoprotein I-dependent lupus anticoagulants.
abstract: There is accumulating evidence showing that lupus anticoagulants (LA) are more strongly associated with thrombosis than anticardiolipin antibodies. In addition, indirect evidence has been presented indicating that beta2GPI-dependent LA are more strongly associated with thrombosis than prothrombin-dependent LA. From this, one may assume that anti-beta2GPI antibodies with LA activity are more pathogenic than anti-beta2GPI antibodies without LA activity. Therefore, it is of the utmost importance to understand the molecular basis on which some anti-beta2GPI antibodies behave as LA. In this presentation, the current knowledge on the interaction of beta2GPI with phospholipids and with anti-beta2GPI antibodies is reviewed and an integrated model for the anti-beta2GPI-dependent LA activity is proposed with implications for a pathogenic role of these particular antibodies.
authors.affiliation: Center for Molecular and Vascular Biology, University of Leuven, Belgium. jef.arnout@med.kuleuven.ac.be
authors.forename: J
authors.initials: J
authors.lastname: Arnout
authors.forename: J
authors.initials: J
authors.lastname: Vermylen
mesh_terms: D000818:Animals; D000838:Anions; D017153:Antibodies, Anticardiolipin / Q000276:immunology; D000915:Antibody Affinity; D000918:Antibody Specificity; D000937:Antigen-Antibody Reactions / Q000276:immunology; D016736:Antiphospholipid Syndrome / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology* / Q000378:metabolism; D001327:Autoimmune Diseases / Q000276:immunology*; D000939:Epitopes / Q000737:chemistry / Q000276:immunology; D006023:Glycoproteins / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000276:immunology; D016682:Lupus Coagulation Inhibitor / Q000276:immunology* / Q000378:metabolism; D046911:Macromolecular Substances; D008322:Mammals / Q000378:metabolism; D018448:Models, Immunological; D010743:Phospholipids / Q000378:metabolism; D011485:Protein Binding; D011487:Protein Conformation; D053482:beta 2-Glycoprotein I
chemical_list: D000838:Anions; D017153:Antibodies, Anticardiolipin; D001324:Autoantigens; D000939:Epitopes; D006023:Glycoproteins; D007140:Immunoglobulin Fab Fragments; D016682:Lupus Coagulation Inhibitor; D046911:Macromolecular Substances; D010743:Phospholipids; D053482:beta 2-Glycoprotein I