title: In vitro characterization of poly(ethylene) glycol calcium citrate microspheres as a delivery system for the study of reparative dentinogenesis.
abstract: The characterization of poly(ethylene) glycol calcium citrate microspheres is described. The calcium content and content uniformity of microspheres, prepared at five concentrations ranging from 46.56 micrograms/g to 81.49 mg/g, were determined by spectroscopy. Under sink conditions first-order in vitro dissolution kinetics were observed. Granules containing approximately 80 mg Ca++/g PEG gave an in vitro calcium release over a 3-day period similar to that of a calcium hydroxide product, Pulpdent.
authors.affiliation: Department of Oral Rehabilitation, University of Otago, Dunedin, New Zealand.
authors.forename: A R
authors.initials: AR
authors.lastname: Hunter
authors.forename: E E
authors.initials: EE
authors.lastname: Kirk
authors.forename: D H
authors.initials: DH
authors.lastname: Robinson
authors.forename: T B
authors.initials: TB
authors.lastname: Kardos
mesh_terms: D000818:Animals; D002021:Buffers; D002118:Calcium / Q000008:administration & dosage* / Q000032:analysis; D019355:Calcium Citrate / Q000008:administration & dosage / Q000737:chemistry; D003785:Dental Pulp Capping; D003809:Dentin, Secondary / Q000254:growth & development; D003810:Dentinogenesis; D016503:Drug Delivery Systems; D015195:Drug Design; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D010949:Plasma; D011092:Polyethylene Glycols; D051381:Rats; D012044:Regression Analysis
chemical_list: D002021:Buffers; D011092:Polyethylene Glycols; D019355:Calcium Citrate; D002118:Calcium