title: Closed-loop controlled administration of propofol using bispectral analysis.
abstract: Ten patients, undergoing elective orthopaedic surgery under spinal anaesthesia, were sedated with propofol using a closed-loop feedback control system. The bispectral index (BIS), a new processed EEG parameter, was used as control variable. Propofol administration was controlled by a patient individualised adaptive model-based controller incorporating target-controlled infusion technology combined with a pharmacokinetic-dynamic model. This feedback control system for propofol administration proved to be adequate and safe. BIS was found to be well suited as control variable.
authors.affiliation: Department of Anaesthetics, University Hospital Gent, Belgium.
authors.forename: E
authors.initials: E
authors.lastname: Mortier
authors.forename: M
authors.initials: M
authors.lastname: Struys
authors.forename: T
authors.initials: T
authors.lastname: De Smet
authors.forename: L
authors.initials: L
authors.lastname: Versichelen
authors.forename: G
authors.initials: G
authors.lastname: Rolly
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000775:Anesthesia, Spinal / Q000379:methods*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000097:blood / Q000494:pharmacology; D004334:Drug Administration Schedule; D016503:Drug Delivery Systems / Q000379:methods*; D004569:Electroencephalography / Q000187:drug effects*; D005246:Feedback; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000187:drug effects; D019637:Orthopedic Procedures; D015742:Propofol / Q000008:administration & dosage* / Q000097:blood / Q000494:pharmacology
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol