title: Effect of feed interval and feed type on splanchnic haemodynamics.
abstract: OBJECTIVE
  To study the effect of enteral feeding on splanchnic blood flow velocity in preterm infants.
  
  
  METHODS
  Coeliac axis and superior mesenteric artery (SMA) blood flow velocity were measured longitudinally in a cohort of 61 babies using Doppler ultrasound.
  
  
  RESULTS
  Babies fed 1 hourly had significantly higher preprandial SMA peak systolic velocity (PSV) than those fed 3 hourly (70 vs 53 cm/s). Those fed 1 hourly showed no postprandial change whereas those fed 3 hourly showed significant postprandial hyperaemia. This hyperaemia had longer latency (42 vs 27 mins) and smaller amplitude (31 vs 25 mins) after expressed breast milk compared with preterm formula. The addition of long chain polyunsaturated fatty acids to the formulas had no effect on the postprandial response.
  
  
  CONCLUSIONS
  Hourly bolus feeding leads to a persistent hyperaemic state in the SMA. The composition of feeds is an important determinant of the postprandial response of the SMA to 3 hourly feeding.
authors.affiliation: Department of Neonatology, Jessop Hospital for Women, Sheffield.
authors.forename: A J
authors.initials: AJ
authors.lastname: Lane
authors.forename: R C
authors.initials: RC
authors.lastname: Coombs
authors.forename: D H
authors.initials: DH
authors.lastname: Evans
authors.forename: R J
authors.initials: RJ
authors.lastname: Levin
mesh_terms: D001783:Blood Flow Velocity; D002445:Celiac Artery / Q000000981:diagnostic imaging; D004750:Enteral Nutrition; D006801:Humans; D007225:Infant Food; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D008137:Longitudinal Studies; D017538:Mesenteric Artery, Superior / Q000000981:diagnostic imaging; D008895:Milk, Human; D013152:Splanchnic Circulation / Q000502:physiology*; D013997:Time Factors; D018608:Ultrasonography, Doppler