Evaluating medication response in ADHD: cognitive, behavioral, and single-subject methodology.
Although evidence supports the use of double-blind placebo medication trials to evaluate methylphenidate (MPH) effects on the core behavioral symptoms of attention-deficit/hyperactivity disorder (ADHD), few studies have demonstrated their utility in examining MPH effects on the cognitive deficits associated with ADHD. This article presents a technique for evaluating behavioral and cognitive dose-response relationships at the single-subject level of analysis. Case study results and multivariate analyses suggest that systematic evaluation of behavioral and cognitive MPH dose-response relationships could lead to more accurate MPH titration and greater long-term multimodal treatment efficacy.
Hale
J B
JB
School of Psychology Program, Moorhead State University, MN 56563, USA.
Hoeppner
J A
JA
DeWitt
M B
MB
Coury
D L
DL
Ritacco
D G
DG
Trommer
B
B
D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000145:classification / Q000188:drug therapy*; D000697:Central Nervous System Stimulants / Q000008:administration & dosage* / Q000009:adverse effects; D002648:Child; D002652:Child Behavior / Q000187:drug effects; D002985:Clinical Protocols; D003071:Cognition / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000008:administration & dosage* / Q000009:adverse effects; D015999:Multivariate Analysis; D009483:Neuropsychological Tests; D016896:Treatment Outcome
D000697:Central Nervous System Stimulants; D008774:Methylphenidate