Structure of human G protein G gamma 5 gene GNG5.
Heterotrimeric G-proteins consist of alpha, beta and gamma subunits that together function in numerous signal transduction pathways. Ggamma subunits form dimers with Gbeta-subunits which together can significantly contribute to signal transduction. So far 11 Ggamma subunit isoforms have been found. Ggamma5 appears to be the most prominently occurring Ggamma-subunit and we now report the genomic structure of human GNG5. The gene spans 6 kb and consists of four exons that range from 92 bp to 290 bp and three introns that range from 134 bp to 3.3 kb. Intron-exon boundaries conform to GT-AG consensus splice junctions. Alternative transcriptional start sites that result from two separate, closely linked promoters in the 5'-flanking region of the gene were confirmed by luciferase reporter-gene assay.
Liu
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B
College of Medicine, University of South Alabama, Mobile, Alabama, 36688, USA.
Aronson
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D020121:5' Untranslated Regions / Q000235:genetics; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D018387:Codon, Initiator / Q000235:genetics; D005091:Exons; D044388:GTP-Binding Protein gamma Subunits / Q000737:chemistry / Q000235:genetics*; D006801:Humans; D007438:Introns; D051379:Mice; D008969:Molecular Sequence Data; D014158:Transcription, Genetic
D020121:5' Untranslated Regions; D018387:Codon, Initiator; C000614654:GNG5 protein, human; D044388:GTP-Binding Protein gamma Subunits