title: Use of folic acid-fortified milk in the elderly population.
abstract: Folic acid deficiency is common in the elderly population, resulting in anaemia, dementia, many neurological sequelae and an indirect role in atheromatous disease. An increase in natural food folate is relatively ineffective at increasing folate status and the use of folate fortification of foodstuffs is recommended. The aim of our study was to assess the benefits of folic acid-fortified milk to the folate status of an elderly institutionalised population. 49 subjects received fortified milk as part of their daily diet for at least 6 months (active group) and 40 subjects received unfortified milk (control group). Our results showed a mean serum folate level in the active group of 5.81 (1.1-17.6) microgram/l compared to the control group mean of 2.16 (0.5-9.4) microgram/l (p < 0.001; normal range for serum folate 2.7-20 microgram/l). Similarly the mean red cell folate level in the active group of 316.5 (130-905) microgram/l was significantly higher than the control group mean of 196.1 (95-490) microgram/l (p < 0.001; normal range for red cell folate 150-1,000 microgram/l). Our results suggest that folic acid-fortified milk is an efficacious and acceptable method of administration of folic acid in the elderly population and we recommend the use of folic acid-fortified milk in the regular daily diet of the elderly population.
authors.affiliation: Mercer's Institute for Research on Ageing, and the Department of Haematology, Saint James's Hospital, Dublin, Ireland.
authors.forename: E M
authors.initials: EM
authors.lastname: Keane
authors.forename: S
authors.initials: S
authors.lastname: O'Broin
authors.forename: B
authors.initials: B
authors.lastname: Kelleher
authors.forename: D
authors.initials: D
authors.lastname: Coakley
authors.forename: J B
authors.initials: JB
authors.lastname: Walsh
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D000818:Animals; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D005527:Food, Fortified; D006801:Humans; D008297:Male; D008875:Middle Aged; D008892:Milk; D012866:Skilled Nursing Facilities; D014805:Vitamin B 12 / Q000097:blood
chemical_list: D005492:Folic Acid; D014805:Vitamin B 12