Myelodysplastic syndrome with hypereosinophilia and a nonrandom chromosomal abnormality dic(1;7): confirmation of eosinophil clonal involvement by fluorescence in situ hybridization.
We report a case of de novo myelodysplastic syndrome (MDS) with hypereosinophilia and dic(1;7) in which eosinophil clonal involvement was confirmed by fluorescence in situ hybridization. There have been two previous reports in the literature of eosinophilic MDS with dic(1;7) or t(1;7) in which eosinophil clonality was demonstrated. The specific breakpoints on chromosomes 1 and 7 differ in the three cases, making it difficult to implicate disruption of a single gene as causative; nevertheless, the nonrandom occurrence of t(1;7) or dic(1;7) with malignant eosinophilic proliferations suggests that this chromosomal rearrangement is involved in the etiology of the disease.
Forrest
D L
DL
Leukemia/Bone Marrow Transplantation Program of British Columbia, Vancouver General Hospital, Canada.
Horsman
D E
DE
Jensen
C L
CL
Berry
B R
BR
Dalal
B I
BI
Barnett
M J
MJ
Nantel
S H
SH
D000368:Aged; D000753:Anemia, Refractory / Q000150:complications / Q000235:genetics*; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics*; D017809:Fatal Outcome; D005819:Genetic Markers; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000150:complications / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic
D005819:Genetic Markers