title: Wave propagation in cardiac tissue and effects of intracellular calcium dynamics (computer simulation study).
abstract: Computer simulation using Luo-Rudy I1 model of ventricular myocyte showed that intracellular calcium dynamics become irregular in case of high rate stimulation. This causes the transition from stationary to nonstationary spiral wave and its breakup in 2D model of cardiac tissue. Obtained results suggest how ventricular fibrillation may occur due to the abnormalities of intracellular calcium dynamics. The short review of existing cardiac cell models with calcium dynamics is presented.
authors.affiliation: Department of Biomathematics, University of California, Los Angeles 90095-1679, USA.
authors.forename: E
authors.initials: E
authors.lastname: Chudin
authors.forename: A
authors.initials: A
authors.lastname: Garfinkel
authors.forename: J
authors.initials: J
authors.lastname: Weiss
authors.forename: W
authors.initials: W
authors.lastname: Karplus
authors.forename: B
authors.initials: B
authors.lastname: Kogan
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000502:physiology; D003198:Computer Simulation; D006321:Heart / Q000033:anatomy & histology* / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism*; D012519:Sarcoplasmic Reticulum / Q000502:physiology
chemical_list: D015220:Calcium Channels; D002118:Calcium