title: Kenny-Caffey syndrome and microorchidism.
abstract: We report on two adolescent boys with Kenny-Caffey syndrome and microorchidism. The first patient had elevated levels of serum follicle-stimulating hormone, but normal levels of luteinizing hormone and testosterone. There was no evidence of a microdeletion of the Y chromosome. The second patient had Leydig cell hyperplasia with normal seminiferous tubules and spermatogenesis, and normal pituitary histologic findings at autopsy. The presence of microorchidism in these patients confirms the previous observations and suggests subfertility, but does not fully clarify the pathogenesis.
authors.affiliation: Department of Pediatrics, Medical College of Georgia, Augusta 30912, USA.
authors.forename: W H
authors.initials: WH
authors.lastname: Hoffman
authors.forename: K
authors.initials: K
authors.lastname: Kovacs
authors.forename: S
authors.initials: S
authors.lastname: Li
authors.forename: A S
authors.initials: AS
authors.lastname: Kulharya
authors.forename: B L
authors.initials: BL
authors.lastname: Johnson
authors.forename: M S
authors.initials: MS
authors.lastname: Eidson
authors.forename: W W
authors.initials: WW
authors.lastname: Cleveland
mesh_terms: D000015:Abnormalities, Multiple / Q000473:pathology; D000293:Adolescent; D000328:Adult; D001827:Body Height; D001842:Bone and Bones / Q000002:abnormalities; D002675:Child, Preschool; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007011:Hypoparathyroidism / Q000473:pathology; D008297:Male; D012886:Skull / Q000002:abnormalities; D013577:Syndrome; D013737:Testis / Q000002:abnormalities*
chemical_list: D005640:Follicle Stimulating Hormone