title: [Ovarian Leydig cell tumor of stromal localization].
abstract: We report the case of a 63-year-old, menopausal patient, yielding hirsutism an associated with clinical virilization. Biological data evidenced an increased androgen production (plasma testosterone at 1.8 and 2.1 ng/ml). Radiological exams (ultrasonography, CT Scan and MRI Scan) failed to find any ovarian tumor, which led to perform an ovarian selective venous percutaneous catheterization. A stromal Leydig cell tumor, associated with a hilar leydigian hyperplasia, was evidenced in pathology. Clinical, biological, radiological and pathological data are successively discussed. Pathophysiology of Leydig cell tumor, particularly when located in the ovarian stroma is also reviewed.
authors.affiliation: Clinique Médicale et Endocrinologique, CHU de Nancy-Brabois, Vandaeuvre-lès-Nancy, France.
authors.forename: S
authors.initials: S
authors.lastname: Hadjadj
authors.forename: F
authors.initials: F
authors.lastname: Maury
authors.forename: J
authors.initials: J
authors.lastname: Leclère
mesh_terms: D005260:Female; D006801:Humans; D007984:Leydig Cell Tumor / Q000473:pathology*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology*; D017154:Stromal Cells / Q000473:pathology