Acute generalized exanthematous pustulosis: a cutaneous adverse effect due to prophylactic antiviral therapy with protease inhibitor.
We describe a human immunodeficiency virus-seronegative man who presented with a skin disorder that we diagnosed as acute generalized exanthematous pustulosis, which we believe was an adverse reaction to combination prophylactic therapy with zidovudine, lamivudine, and protease inhibitor for human immunodeficiency virus. Cutaneous adverse effects are rarely reported with the use of these antiviral drugs.
Aquilina
C
C
Service de Dermatovénéréologie, Hôpital La Grave, Toulouse, France.
Viraben
R
R
Roueire
A
A
D000208:Acute Disease; D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects*; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology*; D005076:Exanthema / Q000139:chemically induced* / Q000175:diagnosis; D015658:HIV Infections / Q000517:prevention & control; D006801:Humans; D019259:Lamivudine / Q000009:adverse effects*; D008297:Male; D011480:Protease Inhibitors / Q000009:adverse effects*; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000175:diagnosis; D015215:Zidovudine / Q000009:adverse effects*
D019380:Anti-HIV Agents; D011480:Protease Inhibitors; D019259:Lamivudine; D015215:Zidovudine