title: The prevalence of antibiotic-resistant faecal Escherichia coli in healthy volunteers in Venezuela.
abstract: Faecal samples were collected from healthy volunteers in two regions in Venezuela, the village of Grulla (n = 195) and the city of Mérida (n = 181), and analysed for the prevalence of antibiotic resistant faecal Escherichia coli as well as the antibiotic susceptibility of the strains isolated. The highest prevalences of resistance were observed for amoxicillin, oxytetracycline, sulfamethoxazole and trimethoprim. The percentages found for Grulla were 46, 38, 44 and 30%, respectively; for Mérida 39, 65, 56 and 36%, respectively. In Mérida, a significantly higher prevalence of resistance for oxytetracycline was found (P < 0.05). Significant differences in the distribution of the MIC values between Grulla and Mérida were observed for amoxicillin, chloramphenicol and oxytetracycline (P < 0.05). In Grulla, the most frequent pattern was resistance to amoxicillin only and in Mérida to oxytetracycline only. Amoxicillin resistance was due to production of TEM1 beta-lactamase.
authors.affiliation: Dept. of Medical Microbiology, University Hospital Maastricht, The Netherlands.
authors.forename: H J
authors.initials: HJ
authors.lastname: van de Mortel
authors.forename: E J
authors.initials: EJ
authors.lastname: Jansen
authors.forename: G J
authors.initials: GJ
authors.lastname: Dinant
authors.forename: N
authors.initials: N
authors.lastname: London
authors.forename: E
authors.initials: E
authors.lastname: Palacios Prü
authors.forename: E E
authors.initials: EE
authors.lastname: Stobberingh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects* / Q000302:isolation & purification*; D005243:Feces / Q000382:microbiology*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011159:Population Surveillance; D015995:Prevalence; D012424:Rural Population; D014505:Urban Population; D014687:Venezuela / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents