title: Plasmatic amino acids in kidney transplantation in children.
abstract: We studied the evolution of plasma amino acid levels in children with chronic kidney failure after undergoing a renal transplantation. Plasma amino acid profile was studied in 10 children just before surgery, at admission in paediatric intensive care unit and 4, 8, 12, 24, 48 and 72 h after transplantation. Previous to the graft, plasma levels of glutamic acid (p < 0.01), hydroxyproline (p < 0.01), citrulline (p < 0.01) and arginine (p < 0.05) were significantly increased, whereas plasma levels of serine (p < 0.01), glutamine (p < 0.03), threonine (p < 0.01), tyrosine (p < 0.01), valine (p < 0.01), leucine (p < 0.01), tryptophan (p < 0.01), branched amino acids (BCAA) (p < 0.01), aromatic amino acids (AAA) (p < 0.01) and essential amino acids (EAA) (p < 0.01) were decreased in relation to control children. The amino acid profile evolution run parallel to the settle down of renal function parameters. Within 72 h after surgery, even before in some cases, all amino acids except tryptophan and arginine reached normal levels.
authors.affiliation: Paediatric Intensive Care Unit, La Paz Children's Hospital, Madrid, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Calvo
authors.forename: F
authors.initials: F
authors.lastname: Ruza
authors.forename: A
authors.initials: A
authors.lastname: Hernanz
authors.forename: R
authors.initials: R
authors.lastname: Madero
authors.forename: I
authors.initials: I
authors.lastname: Arroyo
authors.forename: M A
authors.initials: MA
authors.lastname: Delgado
mesh_terms: D000293:Adolescent; D000596:Amino Acids / Q000097:blood*; D002648:Child; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male
chemical_list: D000596:Amino Acids