Persyn, a member of the synuclein family, has a distinct pattern of expression in the developing nervous system.
The synucleins are a unique family of small intracellular proteins that have recently attracted considerable attention because of their involvement in human neurodegenerative diseases. We have cloned a new member of the synuclein family called persyn. In contrast to other synucleins, which are presynaptic proteins of CNS neurons, persyn is a cytosolic protein that is expressed predominantly in the cell bodies and axons of primary sensory neurons, sympathetic neurons, and motoneurons. Northern blotting, in situ hybridization, Western blotting, and immunohistochemistry revealed that persyn mRNA and protein are expressed in these neurons from the earliest stages of axonal outgrowth and are maintained at a high level throughout life. Persyn also becomes detectable in evolutionary recent regions of the brain by adulthood.
Buchman
V L
VL
School of Biomedical Sciences, University of St. Andrews, Bute Medical Buildings, St. Andrews, Fife KY16 9AJ, Scotland, United Kingdom.
Hunter
H J
HJ
Pinõn
L G
LG
Thompson
J
J
Privalova
E M
EM
Ninkina
N N
NN
Davies
A M
AM
D000367:Age Factors; D000818:Animals; D001369:Axons / Q000737:chemistry / Q000378:metabolism; D003001:Cloning, Molecular; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D009046:Motor Neurons / Q000737:chemistry / Q000648:ultrastructure; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000378:metabolism; D009420:Nervous System / Q000737:chemistry* / Q000196:embryology*; D016900:Neurofilament Proteins / Q000378:metabolism; D009475:Neurons, Afferent / Q000737:chemistry / Q000648:ultrastructure; D012333:RNA, Messenger / Q000032:analysis; D011817:Rabbits; D017386:Sequence Homology, Amino Acid; D051843:Synucleins; D012668:Trigeminal Ganglion / Q000737:chemistry / Q000166:cytology; D051845:gamma-Synuclein
D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; D016900:Neurofilament Proteins; D012333:RNA, Messenger; C104249:SNCG protein, human; D051843:Synucleins; D051845:gamma-Synuclein