Relationship between alcoholism and CYP2E1 C/D polymorphism.
The genotypes of the CYP2E1 loci of 35 alcoholic and 130 nonalcoholic (healthy controls) Japanese were investigated to determine the relationship between CYP2E1 (C/D) polymorphism and susceptibility to alcohol dependence. There was a significant (d.f. = 1, chi2 = 11.0, p < 0.001) difference in the CYP2E1 C gene frequency between alcohol dependents (0.41) and controls (0.28), suggesting that the C gene of CYP2E1 may be related to the risk of developing alcoholism in Japanese, whereas the frequency of the D gene was higher among controls than alcoholics. Healthy Japanese controls showed a significantly (d.f. = 1, chi2 = 30.1, p < 0.001) higher frequency of the C allele than Swedish healthy controls (0. 10) did.
Iwahashi
K
K
Department of Neuropsychiatry, Kagawa Medical School, Miki-cho, Kita-gun, Kagawa, Japan.
Ameno
S
S
Ameno
K
K
Okada
N
N
Kinoshita
H
H
Sakae
Y
Y
Nakamura
K
K
Watanabe
M
M
Ijiri
I
I
Harada
S
S
D000328:Adult; D000437:Alcoholism / Q000201:enzymology* / Q000235:genetics*; D000483:Alleles; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007564:Japan; D008297:Male; D011110:Polymorphism, Genetic
D019392:Cytochrome P-450 CYP2E1