Role of low-dose estrogen-testosterone combination therapy in men with oligospermia.
OBJECTIVE
To determine if low doses of estrogen and testosterone can improve the semen quality in oligospermic men.


METHODS
Prospective, nonrandomized, noncontrolled, clinical study.


METHODS
Primary level care in private practice.


METHODS
Fourteen physically healthy and androgenized oligospermic men were selected for the study.


METHODS
Combined low-dose estrogen-testosterone was administered orally for 4 months.


METHODS
Semen parameters.


RESULTS
Nine cases (64.2%) showed definite improvement in the semen quality, five cases (35.8%) did not show much improvement. The wives of three patients (21.4%) became pregnant within 6 months of the initiation of therapy.


CONCLUSIONS
Low-dose estrogen and testosterone may significantly improve the semen quality in men with oligospermia.
Sah
P
P
Arogya Niketan Private Limited, Uttarpara, India. purushottamsah@hotmail.com
D000328:Adult; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004967:Estrogens / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D009845:Oligospermia / Q000188:drug therapy*; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D013739:Testosterone / Q000627:therapeutic use*
D004967:Estrogens; D013739:Testosterone