Four acetylcholinesterase genes in the nematode Caenorhabditis elegans.
Whereas a single gene encodes acetylcholinesterase (AChE) in vertebrates and most insect species, four distinct genes have been cloned and characterized in the nematode Caenorhabditis elegans. We found that ace-1 (mapped to chromosome X) is prominently expressed in muscle cells whereas ace-2 (located on chromosome I) is mainly expressed in neurons. Ace-x and ace-y genes are located in close proximity on chromosome II where they are separated by only a few hundred base pairs. The role of these two genes is still unknown.
Arpagaus
M
M
Groupe Cholinestérases, DCC-Inra, Montpellier, France.
Combes
D
D
Culetto
E
E
Grauso
M
M
Fedon
Y
Y
Romani
R
R
Toutant
J P
JP
D000110:Acetylcholinesterase / Q000235:genetics* / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D017173:Caenorhabditis elegans / Q000201:enzymology / Q000235:genetics*; D008969:Molecular Sequence Data; D014018:Tissue Distribution
D000110:Acetylcholinesterase