Half mustard (CEES) induced damage to rabbit cornea: attenuating effect of taurine-pyruvate-alpha-ketoglutarate-pantothenate mixture.
Studies have been conducted on the corneal damage by half mustard (2-chloroethyl-ethyl sulfide, CEES) and its possible prevention by a mixture of taurine, alpha-ketoglutarate, pyruvate and pantothenate. CEES has been found to damage the membrane permeability function of the corneal epithelium as evidenced by increased flux of the rubidium ion from the epithelial to the endothelial side. The cornea also loses its transparency. These damaging effects are preventable by the above mixture labeled as VM. It is conceived that use of such a mixed formulation may provide a pharmacological means of prophylactic and post-exposure treatment against the tissue damage caused by exposure to the mustards.
Varma
S D
SD
University of Maryland at Baltimore, 21201-1192, USA.
Devamanoharan
P S
PS
Ali
A H
AH
Brozetti
J
J
Petrali
J
J
Lehnert
E
E
Weir
A
A
D000818:Animals; D002619:Chemical Warfare Agents / Q000633:toxicity*; D003315:Cornea / Q000187:drug effects* / Q000378:metabolism; D003318:Corneal Opacity / Q000139:chemically induced* / Q000378:metabolism / Q000517:prevention & control; D004338:Drug Combinations; D066298:In Vitro Techniques; D007656:Ketoglutaric Acids / Q000627:therapeutic use*; D009151:Mustard Gas / Q000031:analogs & derivatives* / Q000633:toxicity; D010205:Pantothenic Acid / Q000627:therapeutic use*; D019289:Pyruvic Acid / Q000627:therapeutic use*; D011817:Rabbits; D012413:Rubidium / Q000378:metabolism; D013654:Taurine / Q000627:therapeutic use*
D002619:Chemical Warfare Agents; D004338:Drug Combinations; D007656:Ketoglutaric Acids; D010205:Pantothenic Acid; D013654:Taurine; C031278:2-chloroethyl ethyl sulfide; D019289:Pyruvic Acid; D012413:Rubidium; D009151:Mustard Gas