[A model of rat's urinary bladder tumor induced by subcutaneous injection of N-butyl-N-(4-hydroxybutyl)-nitrosamine].
A model of urinary bladder tumor was developed in the rat by subcutaneous injection of N-dibutyl-N-(4-hydroxybutyl) nitrosamine. A direct dose-tumor frequency correlation was established. Maximum effect (100%) was recorded with administration of 70 mg of the carcinogenic agent twice a week, for 3 months. Among neoplasms induced were transitional-cell and in situ carcinoma, and multiple papilloma of the bladder. Carcinogenesis was found to involve a significant rise in the activity of urinary beta-gluco-uronidase which may be used as a diagnostic testing procedure.
Pliss
G B
GB
Prof. N.N. Petrov Research Institute of Oncology, Health Ministry of the RF, St. Petersburg.
Vlasov
N N
NN
Iogannsen
M G
MG
Frolov
A G
AG
D000818:Animals; D002085:Butylhydroxybutylnitrosamine / Q000008:administration & dosage / Q000633:toxicity*; D002273:Carcinogens / Q000008:administration & dosage / Q000633:toxicity*; D002278:Carcinoma in Situ / Q000139:chemically induced; D002295:Carcinoma, Transitional Cell / Q000139:chemically induced; D004195:Disease Models, Animal; D005966:Glucuronidase / Q000652:urine; D010212:Papilloma / Q000139:chemically induced; D051381:Rats; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced* / Q000201:enzymology / Q000652:urine
D002273:Carcinogens; D002085:Butylhydroxybutylnitrosamine; D005966:Glucuronidase