title: Anti-prothrombin antibodies and their relation with thrombosis and lupus anticoagulant.
abstract: Antiphospholipid antibodies are a heterogeneous group of antibodies, comprising antibodies with different antigen specificity. Prothrombin is one of the antigens which can be detected by antiphospholipid antibodies and therefore anti-prothrombin antibodies belong to the antiphospholipid antibody family. The presence of antiphospholipid antibodies correlates strongly with thromboembolic complications; however a mechanism by which these autoantibodies induce a thrombotic complication in vivo is not understood. The classic assays for the detection of antiphospholipid antibodies (LAC and anticardiolipin ELISAs) aim to measure all the antiphospholipid antibodies present in the samples without making a distinction between the different subspecificities of the antibodies present in one single sample. Moreover, most of the in-vitro studies performed were carried out with total IgGs, which contain a mixture of antibodies. The absence of an accurate characterization of the plasma samples and the lack of specificity of the IgGs used in in-vitro tests makes it difficult to determine the contribution of antiprothrombin antibodies to the thrombotic complications. Here we review and critically analyse the literature regarding the clinical relevance of the presence of antiprothrombin antibodies and the possible participation of these antibodies in the pathogenesis of the thrombotic complications.
authors.affiliation: Department of Haematology, University Medical Centre Utrecht, The Netherlands.
authors.forename: P G
authors.initials: PG
authors.lastname: de Groot
authors.forename: D A
authors.initials: DA
authors.lastname: Horbach
authors.forename: M J
authors.initials: MJ
authors.lastname: Simmelink
authors.forename: E
authors.initials: E
authors.lastname: van Oort
authors.forename: R H
authors.initials: RH
authors.lastname: Derksen
mesh_terms: D000818:Animals; D017153:Antibodies, Anticardiolipin / Q000276:immunology; D000918:Antibody Specificity; D016736:Antiphospholipid Syndrome / Q000276:immunology; D001324:Autoantigens / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology*; D001777:Blood Coagulation / Q000276:immunology; D002417:Cattle; D003429:Cross Reactions; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007020:Hypoprothrombinemias / Q000235:genetics / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D018082:Kringles; D016682:Lupus Coagulation Inhibitor / Q000032:analysis / Q000276:immunology*; D008322:Mammals / Q000276:immunology; D011516:Prothrombin / Q000276:immunology*; D019851:Thrombophilia / Q000276:immunology*
chemical_list: D017153:Antibodies, Anticardiolipin; D001324:Autoantigens; D007074:Immunoglobulin G; D016682:Lupus Coagulation Inhibitor; D011516:Prothrombin