title: [Comparative study of beta irradiation (106Ru/106Rh) and gamma irradiation (125I) on the rabbit eye].
abstract: We compared beta irradiation (106Ru/106Rh) to gamma irradiation (125I) on the normal rabbit eye, using ophthalmic plaques to deliver doses similar to those recommended in man for choroidal melanoma treatment. A detailed dosimetry was performed and the animals were followed up by clinical and histological examinations during 1 year. The mean total doses were either comparable, or larger with iodine-125, but the globes treated with ruthenium-106 exhibited more damaging effects: total destruction of the chorioretina on the plaque site, abnormalities of the retinal vessels and of the close nerve fiber layers, cavernous atrophy of the optic nerve. In the eyes treated with iodine-125, only the external retinal layers were destroyed.
authors.affiliation: Clinique ophtalmologique, CHU G. Montpied, Clermont-Ferrand, France.
authors.forename: F
authors.initials: F
authors.lastname: Bacin
authors.forename: S
authors.initials: S
authors.lastname: Amara
authors.forename: J L
authors.initials: JL
authors.lastname: Kemeny
authors.forename: R
authors.initials: R
authors.lastname: Rozan
authors.forename: J J
authors.initials: JJ
authors.lastname: Bard
authors.forename: D
authors.initials: D
authors.lastname: Donnarieix
mesh_terms: D000818:Animals; D001610:Beta Particles; D002829:Choroid / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005123:Eye / Q000473:pathology / Q000528:radiation effects*; D005451:Fluorescein Angiography; D005720:Gamma Rays; D007457:Iodine Radioisotopes; D009900:Optic Nerve / Q000528:radiation effects; D011817:Rabbits; D011868:Radioisotopes; D012016:Reference Values; D012160:Retina / Q000528:radiation effects; D012238:Rhodium; D012429:Ruthenium Radioisotopes
chemical_list: D007457:Iodine Radioisotopes; D011868:Radioisotopes; D012429:Ruthenium Radioisotopes; D012238:Rhodium