title: Comparison testing of the irritancy of children's liquid bubble bath using a modified human repeat insult patch test.
abstract: BACKGROUND
  Bubble baths are common products used by parents with young children. Some dermatologists and pediatricians do not recommend the use of these products.
  
  
  OBJECTIVE
  The purpose of this study was to compare the irritancy of nine children's liquid bubble bath solutions.
  
  
  METHODS
  A modified human repeat insult patch test (HRIPT) was used to rank order the irritancy of nine bubble bath preparations. Erythema, scaling, and fissuring were evaluated at the patch test sites.
  
  
  RESULTS
  The nine products tested varied in their ability to cause irritation. Based on the degree of erythema, the least irritation was produced with Sesame Street Fresh Apple Splash bubble bath.
  
  
  CONCLUSIONS
  This study suggests that there are differences in the irritancy of brands of children's liquid bubble bath and that recommendations can be made by both dermatologists and pediatricians when parents choose to use these products on their children.
authors.affiliation: Dermatology Service, US Army Medical Activity, Heidelberg, Germany; the Department of Dermatology, University of Colorado Health Sciences Center, Denver, Colorado, USA.
authors.forename: N Y
authors.initials: NY
authors.lastname: West
authors.forename: J E
authors.initials: JE
authors.lastname: Fitzpatrick
authors.forename: E M
authors.initials: EM
authors.lastname: Jackson
mesh_terms: D000328:Adult; D001494:Baths; D002626:Chemistry, Pharmaceutical; D002648:Child; D017453:Dermatitis, Irritant / Q000175:diagnosis / Q000209:etiology*; D004890:Erythema / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D008875:Middle Aged; D010290:Parents / Q000193:education; D010328:Patch Tests / Q000379:methods*; D010476:Perfume / Q000009:adverse effects* / Q000737:chemistry; D013501:Surface-Active Agents / Q000009:adverse effects* / Q000737:chemistry
chemical_list: D010476:Perfume; D013501:Surface-Active Agents