title: Comparative development of Taenia solium in experimental models.
abstract: Various mammals were evaluated as experimental models of adult Taenia solium. Suppressed and nonsuppressed hosts were used as experimental models. Infections were performed per os with cysticerci obtained from pigs; immunosuppression was induced with methyl prednisolone acetate at intervals of 10-14 days after infection. Tapeworms developed in hamsters, gerbils, and chinchillas but failed to develop in rabbits, cats, pigs, and rhesus monkeys. In infectable animals, treatment with the steroid facilitated maintenance and development of the parasite, and more tapeworms were obtained. Mature and some pregravid proglottids were recovered from hamsters and gerbils, whereas a gravid T. solium was obtained from a chinchilla at 12 wk postinfection. Eggs recovered from the chinchilla transformed into cysticerci in a pig 12 wk after oral infection. The T. solium-chinchilla experimental system seems to be an alternative definitive host for this parasite and thus the basis for a great diversity of studies.
authors.affiliation: Departamento de Microbiología y Parasitología, Universidad Nacional Autónoma de México, Faculdad de Medicina, D.F.
authors.forename: P
authors.initials: P
authors.lastname: Maravilla
authors.forename: G
authors.initials: G
authors.lastname: Avila
authors.forename: V
authors.initials: V
authors.lastname: Cabrera
authors.forename: L
authors.initials: L
authors.lastname: Aguilar
authors.forename: A
authors.initials: A
authors.lastname: Flisser
mesh_terms: D000818:Animals; D000947:Antigens, Helminth / Q000032:analysis; D002415:Cats; D002682:Chinchilla; D006224:Cricetinae; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D005243:Feces / Q000469:parasitology; D005260:Female; D005849:Gerbillinae; D007165:Immunosuppression Therapy; D008253:Macaca mulatta; D008297:Male; D008647:Mesocricetus; D011817:Rabbits; D013552:Swine; D013621:Taenia / Q000254:growth & development* / Q000276:immunology / Q000302:isolation & purification; D013622:Taeniasis / Q000276:immunology / Q000469:parasitology*
chemical_list: D000947:Antigens, Helminth