[The level of interleukins (IL-1 and IL-2) and of IL-2R+ cells in patients with acute and chronic pyelonephritis].
It has been shown that in patients with acute pyelonephritis a spontaneous production of the interleukin IL-1 remains unchanged, while that stimulated with the aid of LPS is significantly below the norm. A spontaneous secretion of IL-2 in patients with chronic pyelonephritis has also been found unchanged, whereas in acute pyelonephritis this same parameter tends to rise above the level recordable in healthy donors. The production of this lymphokine stimulated with the aid of PhHA is significantly lower both in acute and chronic pyelonephritis. The level of cells carrying receptors to IL-2 is appreciably above the norm in patients with acute pyelonephritis, whereas in those presenting with the chronic process this parameter does not differ from that in the control group. The data obtained suggest distinctive features in the interleukin link of immunity (IL-1, IL-1, IL-2P) in patients with pyelonephritis.
Drannik
G N
GN
Pasechnikov
S P
SP
Driianskaia
V E
VE
Kushko
L Ia
LIa
Ozvinchuk
I I
II
Nikitin
O D
OD
Gordienko
S M
SM
D000208:Acute Disease; D002478:Cells, Cultured; D002908:Chronic Disease; D006801:Humans; D007375:Interleukin-1 / Q000097:blood*; D007376:Interleukin-2 / Q000097:blood*; D007958:Leukocyte Count; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D011704:Pyelonephritis / Q000276:immunology*; D015375:Receptors, Interleukin-2 / Q000097:blood*
D007375:Interleukin-1; D007376:Interleukin-2; D015375:Receptors, Interleukin-2