title: A case of superficial leiomyosarcoma, and a review of Japanese cases.
abstract: We report a case of leiomyosarcoma in a 55-year-old Japanese female. She developed an erythematous nodule, 1.5 cm in diameter, on her right thigh. The totally excised specimen contained tumor cells with variously sized, chromatin-rich nuclei. Gitter staining revealed the so-called encased picture, immunohistopathological staining was positive for smooth muscle actin, and electron microscopy revealed filaments with focal densities. A diagnosis of leiomyosarcoma was made based on these findings, which suggested a muscle cell origin. Normal arrector pili muscles were continuous from the tumor, further suggesting the tumor's origin. The presence of Epstein-Barr virus-encoded RNA (EBER) was examined by in situ hybridization with negative results.
authors.affiliation: Department of Dermatology, Kumamoto University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Wakasugi
authors.forename: K
authors.initials: K
authors.lastname: Kayashima
authors.forename: T
authors.initials: T
authors.lastname: Ono
mesh_terms: D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007564:Japan; D007890:Leiomyosarcoma / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D013848:Thigh