[Somatostatin inhibited pain modulation action of substance P in spinal cord].
In the present study, the effect of somatostatin (SST) on pain modulation induced by substance P in spinal cord was studied. The results showed that intrthecal injection of SST increases pain threshold, prevented pain response and c-fos expression in spinal cord induced by SP. Injection of formalin in the hindpaw induced pain response and increased the SP-LI, which could be inhibited by injection of SST. It is suggested that the analgesic effect of SST may be resulted from the inhibition of the noxious response induced by SP.
Ruan
H Z
HZ
Department of Physiology, Third Military Medical College, Chongqing.
Li
X C
XC
Cai
W Q
WQ
D000818:Animals; D005260:Female; D006727:Hormone Antagonists / Q000494:pharmacology; D008297:Male; D009619:Nociceptors / Q000502:physiology*; D017288:Pain Threshold / Q000187:drug effects*; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar; D013004:Somatostatin / Q000494:pharmacology*; D013116:Spinal Cord / Q000502:physiology*; D013373:Substance P / Q000494:pharmacology*
D006727:Hormone Antagonists; D016760:Proto-Oncogene Proteins c-fos; D013373:Substance P; D013004:Somatostatin