title: Distant skin and soft tissue metastases from sarcomas.
abstract: OBJECTIVE
  This small series documents the clinical and pathological features and the rarity of distant skin and soft tissue metastases from sarcomas.
  
  
  METHODS
  Five cases of sarcomas from different anatomical locations that had metastasized to skin and subcutaneous soft tissue were identified in three women and two men. The age range was 41-77 years. The primary tumors had wide excisions, followed by either radiation or chemotherapy, or both. The histological types were epithelioid sarcoma, malignant fibrous histiocytoma, malignant peripheral nerve sheath tumor, and leiomyosarcoma. Metastases occurred to the skin and soft tissue of the chest wall, leg, breast, and abdominal wall. The diagnosis was established by excision biopsies for three cases and by needle biopsy and fine-needle aspiration for two cases.
  
  
  RESULTS
  Three patients died within 7 months of the diagnosis of soft tissue metastases that were always histologically high grade and never solitary. One patient is alive with lung metastasis discovered 17 months after excision of primary. Lung metastases occurred either simultaneously or within a short period after soft tissue metastases.
  
  
  CONCLUSIONS
  Distant skin and soft tissue metastases from sarcomas are very rare and often occur as a terminal event.
authors.affiliation: Department of Pathology, University of Pittsburgh Medical Center, Pennsylvania 15213, USA.
authors.forename: U N
authors.initials: UN
authors.lastname: Rao
authors.forename: S H
authors.initials: SH
authors.lastname: Hanan
authors.forename: M T
authors.initials: MT
authors.lastname: Lotze
authors.forename: C P
authors.initials: CP
authors.lastname: Karakousis
mesh_terms: D000328:Adult; D000368:Aged; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012509:Sarcoma / Q000556:secondary*; D012878:Skin Neoplasms / Q000556:secondary*; D012983:Soft Tissue Neoplasms / Q000556:secondary*