Signal transduction via Ras.
Ras is a major regulator of cell growth. It is a GTP-binding protein that functions as a molecular switch, cycling between the GDP-bound OFF and GTP-bound ON states. In the GTP-bound state it interacts with effector proteins that mediate the biological function. It is found as an oncogene in about 30% of human tumors. Structural and mechanistic studies on Ras and its interaction with effectors and GAP will be discussed in the context of the biology and pathophysiology of this protein.
Wittinghofer
A
A
Max-Planck-Institut für molekulare Physiologie, Dortmund, Germany.
D001120:Arginine / Q000737:chemistry; D020134:Catalytic Domain; D004789:Enzyme Activation; D020558:GTP Phosphohydrolases / Q000378:metabolism; D020690:GTPase-Activating Proteins; D006801:Humans; D006868:Hydrolysis; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry / Q000378:metabolism; D015398:Signal Transduction; D020703:ras GTPase-Activating Proteins; D018631:ras Proteins / Q000378:metabolism*
D020690:GTPase-Activating Proteins; D011506:Proteins; D020703:ras GTPase-Activating Proteins; D001120:Arginine; D020558:GTP Phosphohydrolases; D018631:ras Proteins