The role of pharmacokinetic modelling and computer simulation in drug formulation design.
The purpose of this study is to develop a formulation for a once-a-day peroral application with controlled release of nitrendipine. The second aim of the study is to define by the use of modelling and computer simulation those critical points in the development of the formulation, the knowledge and controlling of which brings a rationalisation in the sense of time and material.
Grabnar
I
I
Faculty of Pharmacy, University of Ljubljana, Slovenia. iztok.grabnar@ffa.uni-lj.si
Belic
A
A
Mrhar
A
A
Karba
R
R
D000284:Administration, Oral; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics*; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003198:Computer Simulation; D003692:Delayed-Action Preparations; D015195:Drug Design; D006801:Humans; D008956:Models, Chemical; D009568:Nitrendipine / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics*; D013997:Time Factors
D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D003692:Delayed-Action Preparations; D009568:Nitrendipine