Cognition and behavior after temporal lobectomy in pediatric patients with intractable epilepsy.
The increased use of surgical intervention for intractable epilepsy during childhood has resulted in a critical need for information concerning possible cognitive and behavioral changes in pediatric patients after surgery. In this pilot study, comprehensive neuropsychologic evaluations were completed on nine children who had a temporal lobectomy for intractable epilepsy before 16 years of age. Performances before and after surgery were compared using cognitive and behavioral measures. Repeated measures analysis of variance did not indicate differences in performance on the basis of laterality of surgery, although the number of left (n = 5) vs right (n = 4) temporal resections was small. Paired comparison t tests, which included all patients, did not suggest marked changes in cognitive functioning after surgery, although decreases in delayed verbal memory were evident. Positive effects on quality of life during the first year after surgical intervention were suggested by reduced internalizing symptoms and increased social interaction. Replication of this study is recommended with a larger number of patients and multicenter collaboration.
Williams
J
J
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock 72202, USA.
Griebel
M L
ML
Sharp
G B
GB
Boop
F A
FA
D000293:Adolescent; D017668:Age of Onset; D000704:Analysis of Variance; D002648:Child; D002652:Child Behavior; D002675:Child, Preschool; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D004827:Epilepsy / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D007839:Functional Laterality; D006801:Humans; D007223:Infant; D007361:Intelligence Tests; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000209:etiology*; D001523:Mental Disorders / Q000175:diagnosis / Q000209:etiology*; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D019635:Neurosurgical Procedures / Q000009:adverse effects*; D010865:Pilot Projects; D012640:Seizures / Q000209:etiology; D012917:Social Adjustment; D013702:Temporal Lobe / Q000601:surgery*