Non-adrenergic, non-cholinergic reflex secretion of parotid saliva in rats elicited by mastication and acid applied on the tongue.
Chewing and acid on the tongue evoked a flow of saliva from the duct-cannulated parotid gland of the conscious rat despite pretreatment with atropine and adrenoceptor antagonists. This non-adrenergic, non-cholinergic (NANC) response depended on an intact parasympathetic innervation and was abolished by a tachykinin antagonist. The present findings are consistent with a physiological role for the secretory NANC mechanisms of the salivary glands.
Ekström
J
J
Department of Pharmacology, Göteborg University, Sweden. jorgen.ekstrom@odontologi.gu.se
D018674:Adrenergic Antagonists / Q000494:pharmacology; D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage; D001285:Atropine / Q000494:pharmacology; D005260:Female; D008409:Mastication / Q000502:physiology*; D010276:Parasympatholytics / Q000494:pharmacology; D010306:Parotid Gland / Q000294:innervation / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012018:Reflex; D012463:Saliva / Q000378:metabolism*; D015320:Tachykinins / Q000037:antagonists & inhibitors
D018674:Adrenergic Antagonists; D010276:Parasympatholytics; D015320:Tachykinins; D001285:Atropine; D001205:Ascorbic Acid