Human endopeptidase 24.15 (THOP1) is localized on chromosome 19p13.3 and is excluded from the linkage region for late-onset Alzheimer disease.
The mapping position of human endopeptidase 24.15 (THOP1) has previously been reported to be within the linkage region for the late-onset Alzheimer disease AD2 locus on chromosome 19q13.3. After localizing THOP1 to the high-resolution cosmid contig map of human chromosome 19, we found that the previous report was incorrect. Results of the hybridization and FISH mapping of positive clones indicated localization of THOP1 to chromosome 19p13.3 and not 19q13. 3. This localization is a correction of wrong chromosomal delegation and excludes THOP1 from the region that shows evidence of linkage to late-onset familial Alzheimer disease.
Torres
M P
MP
Biology and Biotechnology Program, Lawrence Livermore National Laboratory, Livermore, California, 94550, USA. mtorres@genelogic.com
Prange
C
C
Lennon
G
G
D000544:Alzheimer Disease / Q000235:genetics*; D002874:Chromosome Mapping / Q000379:methods; D002888:Chromosomes, Human, Pair 19; D020224:Expressed Sequence Tags; D008040:Genetic Linkage; D006801:Humans; D017403:In Situ Hybridization; D008666:Metalloendopeptidases / Q000235:genetics*
D008666:Metalloendopeptidases; C022510:thimet oligopeptidase