Delayed haemolytic transfusion reaction due to anti-M antibody.
A female patient with delayed haemolytic transfusion reaction due to anti-M antibody is described. Diagnosis was based on laboratory evidence of haemolysis and on characteristic serological findings. Anti-M was detected in the recipient's serum 7 d after the last transfusion episode. This alloantibody had not been present in the pretransfusion serum. In addition, the direct antiglobulin test was positive on post-transfusion testing and the implicated antibody was eluted from post-transfused red cells. Delayed haemolytic transfusion reactions have long been recognized as a potential hazard of transfusion therapy, but such cases due to anti-M are extremely rare.
Sancho
J M
JM
Servicio de Hematología y Hemoterapia, Hospital Universitario Germans Trias y Pujol, Badalona, Spain.
Pujol
M
M
Fernández
F
F
Soler
M
M
Manzano
P
P
Feliu
E
E
D000230:Adenocarcinoma / Q000601:surgery; D003110:Colonic Neoplasms / Q000601:surgery; D017707:Erythrocyte Transfusion / Q000009:adverse effects*; D004912:Erythrocytes / Q000276:immunology*; D017809:Fatal Outcome; D005260:Female; D006461:Hemolysis / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology*; D007518:Isoantibodies / Q000276:immunology*; D008875:Middle Aged; D014181:Transplantation Immunology
D007075:Immunoglobulin M; D007518:Isoantibodies