Hepatic and renal expression of senescence marker protein-30 and its biological significance.
A novel rat hepatic protein was detected and isolated, the amount of which is downregulated in an androgen-independent manner with ageing. This protein was designated as senescence marker protein-30 (SMP30). Senescence marker protein-30 turned out to be identical to a hepatic calcium-binding protein called regucalcin (RC). This review gives an overview of SMP30 in its structure, expression and possible physiological function(s). A hypothetical role of SMP30 in ageing and calcium homeostasis is also discussed.
Fujita
T
T
Department of Molecular Pathology, Tokyo Metropolitan Institute of Gerontology, Japan. tofujita@tmig.or.jp
Shirasawa
T
T
Inoue
H
H
Kitamura
T
T
Maruyama
N
N
D000375:Aging / Q000502:physiology; D000818:Animals; D002135:Calcium-Binding Proteins / Q000032:analysis* / Q000235:genetics / Q000502:physiology; D002265:Carboxylic Ester Hydrolases; D015536:Down-Regulation / Q000502:physiology; D047908:Intracellular Signaling Peptides and Proteins; D007668:Kidney / Q000737:chemistry*; D008099:Liver / Q000737:chemistry*; D051381:Rats; D015238:Sulfotransferases; D015854:Up-Regulation / Q000502:physiology
D002135:Calcium-Binding Proteins; D047908:Intracellular Signaling Peptides and Proteins; D015238:Sulfotransferases; C028152:alcohol sulfotransferase; D002265:Carboxylic Ester Hydrolases; C513325:Rgn protein, rat