Accelerated recovery of glycerol-induced acute renal failure in rats with previous partial hepatectomy.
Several studies have reported a favorable effect following the administration of growth factors during the course of acute renal failure. To evaluate the effect of an increased endogenous production of growth factors, rats underwent 70% hepatectomy before glycerol-induced acute renal failure. The renal function was then monitored 12 and 48 h after glycerol injection in conscious rats. Twelve hours after the induction of acute renal failure, a reduction in creatinine clearance and sodium reabsorption was seen in both prehepatectomized and sham-hepatectomized rats. At 48 h, there was total recovery of glomerular filtration and tubular function in the prehepatectomized rats, whereas the sham-hepatectomized rats still had reduced glomerular filtration and sodium reabsorption. In rats treated with dexamethasone before hepatectomy and studied 48 h after the induction of acute renal failure, the protective action on renal function seen in prehepatectomized rats was totally blocked. A semiquantitative histological analysis done 48 h after the induction of acute renal failure demonstrated a fourfold increase in the number of necrotic tubules in both sham-hepatectomized and dexamethasone-treated rats as compared with hepatectomized rats. It is concluded that partial hepatectomy, a maneuver used to increase the endogenous synthesis of growth factors, accelerates recovery of renal function following glycerol-induced acute renal failure.
Homsi
E
E
Division of Nephrology, Universidade Estadual de Campinas, São Paulo, Brazil.
Pires de Oliveira Dias
E
E
Figueiredo
J F
JF
Gontijo
J A
JA
D000042:Absorption / Q000502:physiology; D058186:Acute Kidney Injury / Q000139:chemically induced / Q000503:physiopathology*; D000818:Animals; D003404:Creatinine / Q000378:metabolism; D003907:Dexamethasone / Q000494:pharmacology; D005919:Glomerular Filtration Rate / Q000502:physiology; D005938:Glucocorticoids / Q000494:pharmacology; D005990:Glycerol; D006498:Hepatectomy / Q000379:methods*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D007684:Kidney Tubules / Q000503:physiopathology; D008297:Male; D011184:Postoperative Period; D011300:Preoperative Care; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000378:metabolism; D013997:Time Factors
D005938:Glucocorticoids; D003907:Dexamethasone; D012964:Sodium; D003404:Creatinine; D005990:Glycerol