[Mitochondrial diseases and stroke].
We review the mitochondrial diseases in which cerebrovascular changes are seen, such as the MERRF syndrome (myoclonic epilepsy and ragged red fibers) or the Kearns-Sayre syndrome (progressive external ophthalmoplegia, retinitis pigmentaria, cerebellar disorders and disorders of cardiac conduction), focusing on the syndrome involving mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS). We consider the different clinical aspects, diagnostic methods, pathophysiological mechanisms of the cerebrovascular involvement as well as therapeutic approaches.
Irimia
P
P
Departamento de Neurología y Neurocirugía, Clínica Universitaria de Navarra, Facultad de Medicina, Universidad de Navarra, Pamplona, España.
Oliveros-Cid
A
A
Martínez-Vila
E
E
D002561:Cerebrovascular Disorders / Q000150:complications* / Q000517:prevention & control*; D006801:Humans; D017240:Mitochondrial Myopathies / Q000150:complications* / Q000235:genetics / Q000628:therapy*