title: Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum.
abstract: Chromosome 2 of Plasmodium falciparum was sequenced; this sequence contains 947,103 base pairs and encodes 210 predicted genes. In comparison with the Saccharomyces cerevisiae genome, chromosome 2 has a lower gene density, introns are more frequent, and proteins are markedly enriched in nonglobular domains. A family of surface proteins, rifins, that may play a role in antigenic variation was identified. The complete sequencing of chromosome 2 has shown that sequencing of the A+T-rich P. falciparum genome is technically feasible.
authors.affiliation: Institute for Genomic Research, Rockville, MD 20850, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Gardner
authors.forename: H
authors.initials: H
authors.lastname: Tettelin
authors.forename: D J
authors.initials: DJ
authors.lastname: Carucci
authors.forename: L M
authors.initials: LM
authors.lastname: Cummings
authors.forename: L
authors.initials: L
authors.lastname: Aravind
authors.forename: E V
authors.initials: EV
authors.lastname: Koonin
authors.forename: S
authors.initials: S
authors.lastname: Shallom
authors.forename: T
authors.initials: T
authors.lastname: Mason
authors.forename: K
authors.initials: K
authors.lastname: Yu
authors.forename: C
authors.initials: C
authors.lastname: Fujii
authors.forename: J
authors.initials: J
authors.lastname: Pederson
authors.forename: K
authors.initials: K
authors.lastname: Shen
authors.forename: J
authors.initials: J
authors.lastname: Jing
authors.forename: C
authors.initials: C
authors.lastname: Aston
authors.forename: Z
authors.initials: Z
authors.lastname: Lai
authors.forename: D C
authors.initials: DC
authors.lastname: Schwartz
authors.forename: M
authors.initials: M
authors.lastname: Pertea
authors.forename: S
authors.initials: S
authors.lastname: Salzberg
authors.forename: L
authors.initials: L
authors.lastname: Zhou
authors.forename: G G
authors.initials: GG
authors.lastname: Sutton
authors.forename: R
authors.initials: R
authors.lastname: Clayton
authors.forename: O
authors.initials: O
authors.lastname: White
authors.forename: H O
authors.initials: HO
authors.lastname: Smith
authors.forename: C M
authors.initials: CM
authors.lastname: Fraser
authors.forename: M D
authors.initials: MD
authors.lastname: Adams
authors.forename: J C
authors.initials: JC
authors.lastname: Venter
authors.forename: S L
authors.initials: SL
authors.lastname: Hoffman
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000953:Antigens, Protozoan / Q000737:chemistry / Q000235:genetics; D001482:Base Composition; D002875:Chromosomes / Q000235:genetics*; D019143:Evolution, Molecular; D017125:Genes, Protozoan; D018503:Genome, Protozoan; D007438:Introns; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics; D008969:Molecular Sequence Data; D005810:Multigene Family; D020161:Physical Chromosome Mapping; D010963:Plasmodium falciparum / Q000235:genetics*; D015800:Protozoan Proteins / Q000737:chemistry / Q000235:genetics*; D016053:RNA, Protozoan / Q000235:genetics; D012352:RNA, Transfer, Glu / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA
chemical_list: D000953:Antigens, Protozoan; D008565:Membrane Proteins; D015800:Protozoan Proteins; D016053:RNA, Protozoan; D012352:RNA, Transfer, Glu; C057495:serine repeat antigen, Plasmodium