title: Skeletal metastases from a granulosa-cell tumor of the ovary: report of a case diagnosed by fine-needle aspiration cytology.
abstract: We report on the fine-needle aspiration cytological findings of a metastatic granulosa-cell tumor of the ovary to bone. The patient had undergone resection of a primary ovarian granulosa-cell tumor 15 yr prior to her last admission. Recently she injured her right hip, sustained after a fall. CT examination revealed hypodense lesions involving the posterior body and the right pedicle of the L1 vertebra. The aspirate from the bone yielded a highly cellular smear, composed of round to oval cells with scanty cytoplasm. Many of the cells revealed the presence of nuclear grooves. In areas, the cells were arranged in clusters resembling Call-Exner bodies. The rarity of skeletal metastases from granulosa-cell tumors can cause diagnostic difficulty in diagnosing this entity. Accurate clinical data, radiological findings, and cytological features are important in arriving at the correct diagnosis.
authors.affiliation: Department of Pathology, Long Island Jewish Medical Center, New Hyde Park, New York 11040, USA.
authors.forename: S D
authors.initials: SD
authors.lastname: Thirumala
authors.forename: T C
authors.initials: TC
authors.lastname: Putti
authors.forename: N S
authors.initials: NS
authors.lastname: Medalie
authors.forename: P G
authors.initials: PG
authors.lastname: Wasserman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D001859:Bone Neoplasms / Q000473:pathology / Q000556:secondary*; D005260:Female; D006106:Granulosa Cell Tumor / Q000556:secondary*; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000473:pathology; D010051:Ovarian Neoplasms / Q000473:pathology*; D014057:Tomography, X-Ray Computed