title: [Mitochondrial diseases and stroke].
abstract: We review the mitochondrial diseases in which cerebrovascular changes are seen, such as the MERRF syndrome (myoclonic epilepsy and ragged red fibers) or the Kearns-Sayre syndrome (progressive external ophthalmoplegia, retinitis pigmentaria, cerebellar disorders and disorders of cardiac conduction), focusing on the syndrome involving mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS). We consider the different clinical aspects, diagnostic methods, pathophysiological mechanisms of the cerebrovascular involvement as well as therapeutic approaches.
authors.affiliation: Departamento de Neurología y Neurocirugía, Clínica Universitaria de Navarra, Facultad de Medicina, Universidad de Navarra, Pamplona, España.
authors.forename: P
authors.initials: P
authors.lastname: Irimia
authors.forename: A
authors.initials: A
authors.lastname: Oliveros-Cid
authors.forename: E
authors.initials: E
authors.lastname: Martínez-Vila
mesh_terms: D002561:Cerebrovascular Disorders / Q000150:complications* / Q000517:prevention & control*; D006801:Humans; D017240:Mitochondrial Myopathies / Q000150:complications* / Q000235:genetics / Q000628:therapy*