title: Sexual maturation and fertility of male and female mice exposed prenatally and postnatally to trivalent and hexavalent chromium compounds.
abstract: The reproductive toxicity of trivalent and hexavalent chromium compounds was investigated in male and female mice exposed to 1000 ppm chromium chloride and potassium dichromate via their mother during gestational and lactational periods. Fertility was reduced in male offspring exposed to either trivalent or hexavalent chromium compounds. Body weights and weights of testes, seminal vesicles and preputial glands were reduced in trivalent-exposed male offspring. The exposure of female mice offspring to trivalent and hexavalent chromium compounds delayed sexual maturation. Fertility was reduced in female offspring exposed to either trivalent or hexavalent chromium compounds. The exposure of female mice to hexavalent chromium compound reduced the number of implantations and viable fetuses respectively. Body weight and weights of ovaries and uteri were reduced in trivalent-exposed female offspring. The results indicate that under our experimental conditions, the exposure of male and female mice offspring to either trivalent or hexavalent chromium compounds during gestational and lactational periods impair reproductive functions and fertility in adulthood.
authors.affiliation: Department of Biology, Faculty of Science, Jerash Private University, Jordan.
authors.forename: M H
authors.initials: MH
authors.lastname: Al-Hamood
authors.forename: A
authors.initials: A
authors.lastname: Elbetieha
authors.forename: H
authors.initials: H
authors.lastname: Bataineh
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002274:Carcinogens, Environmental; D002857:Chromium / Q000494:pharmacology*; D017608:Chromium Compounds / Q000494:pharmacology*; D004326:Drinking / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects*; D005333:Fetus / Q000187:drug effects; D007774:Lactation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D012741:Sexual Maturation / Q000187:drug effects*
chemical_list: D002274:Carcinogens, Environmental; D017608:Chromium Compounds; D002857:Chromium; C074702:chromium hexavalent ion