title: [Cost-effectiveness of conservative therapy of knee joint osteoarthritis].
abstract: Hyaluronic acid (HYA) recently in several clinical studies has been shown to reduce gonarthrotic pain and to improve mobility. As an outcome measure usually the medical judgement and/or patient satisfaction as well as the Lequesne-index or the Euroquol index were used. The objective of this study was to investigate the cost-effectiveness (CEA) of HYA in a German ambulatory setting.
  
  
  METHODS
  In 5 orthopedic specialist's practices a total of 179 patients with gonarthrosis have been evaluated, 90 under treatment with HYA, 89 with standard treatment (SDT). After 6 months the effects of HYA as measured by the Lequesne- and Euroquol-indices have been compared to SDT and analysed for cost of treatment.
  
  
  RESULTS
  All index values for pain and mobility show--mostly significant--differences in favour of HYA, e.g. 92.4% of all patients under HYA achieved optimum values of Euroquol for general satisfaction vs. 42.9% in the reference group. The direct medical costs of 796, 11 DM are higher for HYA by 286, 85 DM (incl. 649 for HYA alone): the cost of medical services are lower by 108 DM, for lost days of work they are lower by 98 DM as compared to SDT. The average cost-effectiveness of HYA was superior for the effects on pain and mobility (e.g. differences of 978 and 328 DM resp. in direct costs), how-ever, indifferent for the complete indices. also marginal cost-effectiveness shows mainly favourable results for the various outcome-dimensions of quality of life used, the values being partly lower than the average cost-effectiveness.
  
  
  CONCLUSIONS
  HYA shows mainly superior effects on quality of life as compared so SDT. Savings occur mainly with the regard to additive therapies and loss of work days. Overall HYA therapy is not more expensive but more beneficial than SDT.
authors.affiliation: Institut für Management im Gesundheitswesen IMAGE GmbH, Universität Hannover.
authors.forename: P
authors.initials: P
authors.lastname: Allhoff
authors.forename: J M
authors.initials: JM
authors.lastname: Graf von der Schulenburg
mesh_terms: D000368:Aged; D003362:Cost-Benefit Analysis; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000191:economics*; D007270:Injections, Intra-Articular; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000191:economics* / Q000628:therapy; D010147:Pain Measurement; D017060:Patient Satisfaction / Q000191:economics; D011446:Prospective Studies; D011788:Quality of Life
chemical_list: D006820:Hyaluronic Acid