title: Oral clonidine for sedation and analgesia in a burn patient.
abstract: Clonidine has both analgesic and sedative actions, and it has been used in a variety of settings as a sedative, or both. We administered oral clonidine with intravenous ketamine to a burn patient to control severe pain. Clonidine produced good analgesia and sedation. In addition, clonidine counterbalanced the sympathetic stimulation of ketamine by virtue of its action in reducing sympathetic outflow. The combination of these two drugs may be useful for burn patients with hypertension or myocardial ischemia.
authors.affiliation: Department of Anesthesiology and Intensive Care Medicine, Osaka City University Medical School, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Kariya
authors.forename: M
authors.initials: M
authors.lastname: Shindoh
authors.forename: S
authors.initials: S
authors.lastname: Nishi
authors.forename: H
authors.initials: H
authors.lastname: Yukioka
authors.forename: A
authors.initials: A
authors.lastname: Asada
mesh_terms: D000284:Administration, Oral; D000700:Analgesics / Q000627:therapeutic use*; D002056:Burns / Q000188:drug therapy* / Q000503:physiopathology; D003000:Clonidine / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use*; D007649:Ketamine / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged
chemical_list: D000700:Analgesics; D006993:Hypnotics and Sedatives; D007649:Ketamine; D003000:Clonidine