title: Loss of heterozygosity in sporadic oesophageal tumors in the tylosis oesophageal cancer (TOC) gene region of chromosome 17q.
abstract: From the genotyping of UK and US tylotic families with a high risk of oesophageal cancer we have previously localized the tylosis-associated cancer susceptibility gene (TOC gene, tylosis oesophageal cancer gene) to a 1 cM region on the long arm of chromosome 17 (Kelsell et al., 1996). In the present study we investigated loss of heterozygosity (LOH) patterns of 35 sporadic squamous cell carcinomas of the oesophagus using six polymorphic microsatellite markers encompassing this locus. Twenty-four of the 35 cases (69%) revealed LOH at one or more loci. Deletion was most frequently observed with the marker D17S801 (64% LOH, informative cases), which shows significant linkage to the TOC locus. The LOH analysis in sporadic oesophageal cancer we report here is thus consistent with the hypothesis that the tylosis oesophageal cancer susceptibility gene is also involved in the pathogenesis of a proportion of sporadic squamous cell carcinomas of the oesophagus.
authors.affiliation: German Cancer Research Centre (Deutsches Krebsforschungszentrum), Heidelberg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: von Brevern
authors.forename: M C
authors.initials: MC
authors.lastname: Hollstein
authors.forename: J M
authors.initials: JM
authors.lastname: Risk
authors.forename: J
authors.initials: J
authors.lastname: Garde
authors.forename: W P
authors.initials: WP
authors.lastname: Bennett
authors.forename: C C
authors.initials: CC
authors.lastname: Harris
authors.forename: K R
authors.initials: KR
authors.lastname: Muehlbauer
authors.forename: J K
authors.initials: JK
authors.lastname: Field
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D002886:Chromosomes, Human, Pair 17; D004938:Esophageal Neoplasms / Q000235:genetics*; D006801:Humans; D015776:Keratoderma, Palmoplantar, Diffuse / Q000235:genetics*; D019656:Loss of Heterozygosity