Complex effects of general anesthesia on sensory processing in the spinal dorsal horn.
A chronic animal preparation allowed us to compare activity of the same single, spinal dorsal horn neurons in the physiologically intact, awake, drug-free state and in the anesthetized state. The inhalation anesthetic enflurane produced profound, and at times, opposite effects on spinal dorsal horn neuron responses to non-noxious and noxious receptive field stimulation. Some effects would not have been predicted, based upon current understanding of anesthetics.
Yanagidani
T
T
Department of Anesthesiology, Yale University, 333 Cedar St., P.O. Box 208051, New Haven, CT 06520-8051, USA.
Ota
K
K
Collins
J G
JG
D000704:Analysis of Variance; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D004737:Enflurane / Q000494:pharmacology*; D009475:Neurons, Afferent / Q000187:drug effects*; D013116:Spinal Cord / Q000166:cytology / Q000187:drug effects*
D018685:Anesthetics, Inhalation; D004737:Enflurane