Adenosine and the nervous system: pharmacological data and therapeutic perspectives.
1. Adenosine acts on a family of G-protein-coupled receptors called purinoreceptors. 2. Four subtypes have been cloned and pharmacologically characterized. 3. The principal pharmacological data and structure-function relations for agonist interactions with P1 receptors are presented. 4. We conclude that the potent role of adenosine in the nervous system may be interesting for the development of drugs targeted at purines and their receptors.
Guieu
R
R
Laboratoire de Biochimie et d'Ingéniérie des Protéines, URA CNRS 1455 Faculté de Médecine Secteur Nord, Marseille, France.
Dussol
B
B
Halimi
G
G
Bechis
G
G
Sampieri
F
F
Berland
Y
Y
Sampol
J
J
Couraud
F
F
Rochat
H
H
D000241:Adenosine / Q000502:physiology* / Q000627:therapeutic use; D000818:Animals; D066298:In Vitro Techniques; D009422:Nervous System Diseases / Q000188:drug therapy*; D009424:Nervous System Physiological Phenomena; D011983:Receptors, Purinergic / Q000187:drug effects*; D018047:Receptors, Purinergic P1 / Q000502:physiology
D011983:Receptors, Purinergic; D018047:Receptors, Purinergic P1; D000241:Adenosine