Distribution of HLA class II alleles among Spanish patients with pemphigus vulgaris.
Twenty-six unrelated Spanish Caucasian individuals affected by pemphigus vulgaris (PV) were HLA typed and frequencies compared with those of 200 ethnically matched healthy controls. Twenty-three out of 26 patients were HLA-DR4. The frequency of HLA-DR14 was also increased (31%; controls: 4%). Of the 23 patients positive for HLA-DR4, 21 carried the DRB1*0402 allele. Therefore, the frequency of HLA-DRB1*0402 among patients was 81% (4% in controls; P=4.7x10(-27), OR=100.8). Interestingly, HLA-DR13, a frequent HLA-DR specificity in the Spanish general population (27%), was absent among the PV patients (P=0.009; Pc=0.1; OR=0.05). Taking together these data, we can conclude that, in the Spanish population, PV is preferentially and strongly associated with HLA-DRB1*0402, whereas DRB1*13 seems to confer a protective effect in our population.
González-Escribano
M F
MF
Servicio de Immunología and Unidad de Dermatología, Hospital Universitario Virgen del Rocío, Servicio Andaluz de Salud, Sevilla, Spain.
Jiménez
G
G
Walter
K
K
Montes
M
M
Perez-Bernal
A M
AM
Rodríguez
M R
MR
Conejo-Mir
J S
JS
Núñez-Roldán
A
A
D000483:Alleles; D004247:DNA / Q000097:blood; D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006680:HLA Antigens / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D010392:Pemphigus / Q000235:genetics* / Q000276:immunology*; D013030:Spain / Q000453:epidemiology; D044465:White People / Q000235:genetics*
D006680:HLA Antigens; D000949:Histocompatibility Antigens Class II; D004247:DNA