Wound healing around endosseous implants in experimental diabetes.
Wound healing has been shown to be altered in diabetes mellitus. The aim of this study was to identify the effects of streptozotocin-induced diabetes on osseointegration. Diabetes was induced in 40-day-old rats by intraperitoneal injection of 70 mg per kg streptozotocin. At 14 days postinjection, implants were placed in the femora of 10 diabetic and 10 age-matched normal rats. Animals were sacrificed at 28 and 56 days following implantation. Histometric results indicated that the quantity of bone formation was similar for diabetic and control animals (P > .05). However, less bone-implant contact was observed for diabetic compared to control animals at both 28 and 56 days (P < .0001). This study demonstrates that the process of osseointegration is affected by streptozotocin-induced diabetes.
Nevins
M L
ML
Department of Periodontology, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA. jfiorell@warren.med.harvard.edu
Karimbux
N Y
NY
Weber
H P
HP
Giannobile
W V
WV
Fiorellini
J P
JP
D000704:Analysis of Variance; D000818:Animals; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000503:physiopathology*; D005269:Femur; D020007:Implants, Experimental; D008297:Male; D016348:Osseointegration / Q000502:physiology*; D010012:Osteogenesis / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D018709:Statistics, Nonparametric; D013311:Streptozocin; D014945:Wound Healing / Q000502:physiology
D015921:Dental Implants; D013311:Streptozocin