[Pulmonary function at the early stage after bone marrow transplantation].
Twenty-one patients, aged 16-41 years, were prospectively followed for pulmonary function prior to and up to nine months after bone marrow transplantation (BMT). All patients had normal radiographs and no clinical signs of pulmonary disease. The FEV1.0%, V25, and of V50/V25 were within the normal ranges for all patients. Percent vital capacity (%VC) and percent diffusing capacity of lung for CO (% DLco) dropped progressively in most of the patients up to 9 months following BMT. Pulmonary function decreased earlier in patients with GVHD as well as patients who received total body irradiation either at a high dose rate (10 cGy/min) or a high lung dose (12 Gy). These asymptomatic declines in pulmonary function were measured by frequent tests of lung function.
Hatta
Y
Y
First Department of Internal Medicine, Nihon University School of Medicine.
Itoh
T
T
Baba
M
M
Izumi
T
T
Sasaki
I
I
Shimojima
H
H
Miyajima
T
T
Aizawa
S
S
Takeuchi
J
J
Horikoshi
A
A
Ohshima
T
T
Sawada
U
U
Amemiya
Y
Y
Horie
T
T
D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D018450:Disease Progression; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications; D019337:Hematologic Neoplasms / Q000628:therapy; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008297:Male; D011446:Prospective Studies; D011879:Radiotherapy Dosage; D012120:Respiration Disorders / Q000209:etiology / Q000503:physiopathology*; D012129:Respiratory Function Tests; D013997:Time Factors; D019172:Transplantation Conditioning; D014916:Whole-Body Irradiation / Q000009:adverse effects