title: [The physicochemical characterization of the agents isolated during the outbreak of epidemic neuropathy in Cuba. I].
abstract: This paper reports on the physical and chemical characteristics of agents isolated from serum samples of patients presenting with epidemic neuropathy. The behaviour of isolated enteroviruses was as described for such viruses. Mild cytopathogenic effects-producing agents behaved in a variable form regarding sensitivity to chloroform; on the other hand they were neither sensitive to phosphonoacetic acid (PAA) nor to guanidine hydrochloride (GHC1) and grew in cells previously treated with bromodeoxyuridine (BDUR). These results suggest the presence of agents resembling enteroviruses and enveloped viruses. Further studies for the characterization of such agents need to be performed.
authors.affiliation: Instituto de Medicina Tropical Pedro Kourí.
authors.forename: M G
authors.initials: MG
authors.lastname: Guzmán
authors.forename: R
authors.initials: R
authors.lastname: Rodríguez
authors.forename: S
authors.initials: S
authors.lastname: Resik
authors.forename: M
authors.initials: M
authors.lastname: Alvarez
authors.forename: L
authors.initials: L
authors.lastname: Morier
authors.forename: A
authors.initials: A
authors.lastname: Castillo
authors.forename: G
authors.initials: G
authors.lastname: Kourí
authors.forename: P
authors.initials: P
authors.lastname: Maś
mesh_terms: D000212:Acyclovir / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology; D001973:Bromodeoxyuridine / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003462:Cuba / Q000453:epidemiology; D004196:Disease Outbreaks; D004770:Enterovirus / Q000737:chemistry* / Q000187:drug effects / Q000302:isolation & purification; D019791:Guanidine / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009902:Optic Neuritis / Q000453:epidemiology / Q000821:virology*; D010523:Peripheral Nervous System Diseases / Q000453:epidemiology / Q000821:virology*; D010746:Phosphonoacetic Acid / Q000494:pharmacology; D013696:Temperature
chemical_list: D000998:Antiviral Agents; D001973:Bromodeoxyuridine; D019791:Guanidine; D010746:Phosphonoacetic Acid; D000212:Acyclovir