title: Sialadenosis: a presenting sign in bulimia.
abstract: BACKGROUND
  Sialadenosis refers to noninflammatory, often recurrent, enlargement of the salivary glands, most frequently the parotids, which is almost always associated with an underlying systemic disorder. These include diabetes, alcoholism, malnutrition, anorexia nervosa, and bulimia. It is thought that the various causes of sialadenosis all result in a common pathogenetic effect in that they produce a peripheral autonomic neuropathy which is responsible for disordered metabolism and secretion, resulting in acinar enlargement.
  
  
  METHODS
  This paper reports a case of sialadenosis as a presenting sign in bulimia and studies the histologic and electron microscopic features of this disease.
  
  
  RESULTS
  Light microscopy showed acini which appeared to be larger than normal and which were composed of plump pyramidal cells containing prominent zymogen granules. There was less interstitial fat, and the ducts were widely dispersed. Electron microscopy showed the acinar cells to be packed with membrane-limited, dark secretory granules some of which showed moulding of their outlines. Cellular organelles and nuclei were inconspicuous.
  
  
  CONCLUSIONS
  Management of sialadenosis depends upon identification of the underlying cause, which must then be corrected. In bulimia, the swellings may be refractory to standard treatment modalities, and parotidectomy may be considered as a last resort to improve the unacceptable aesthetics.
authors.affiliation: Division of Oral Pathology, University of Witwatersrand, Johannesburg, South Africa.
authors.forename: H
authors.initials: H
authors.lastname: Coleman
authors.forename: M
authors.initials: M
authors.lastname: Altini
authors.forename: S
authors.initials: S
authors.lastname: Nayler
authors.forename: A
authors.initials: A
authors.lastname: Richards
mesh_terms: D000328:Adult; D002032:Bulimia / Q000150:complications*; D005260:Female; D006801:Humans; D010305:Parotid Diseases / Q000209:etiology* / Q000473:pathology; D010306:Parotid Gland / Q000473:pathology