title: Alteration of regional cerebral glucose utilization with delusions in Alzheimer's disease.
abstract: The authors examined 65 patients with Alzheimer's disease for delusions and explored the relationship of delusions with regional cerebral glucose metabolism determined by [18F]fluorodeoxyglucose PET. In patients with delusions (n = 26), normalized glucose metabolism was significantly increased in the left inferior temporal gyrus and significantly decreased in the left medial occipital region as compared with those without delusions (n = 39). The two groups were similar in age, sex, and dementia severity. These results suggest that delusions in Alzheimer's disease are attributable to a dysfunction in specific brain areas rather than a simple reaction to intellectual deficits.
authors.affiliation: Division of Clinical Neuroscience, Hyogo Institute for Aging Brain and Cognitive Disorders, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Hirono
authors.forename: E
authors.initials: E
authors.lastname: Mori
authors.forename: K
authors.initials: K
authors.lastname: Ishii
authors.forename: H
authors.initials: H
authors.lastname: Kitagaki
authors.forename: M
authors.initials: M
authors.lastname: Sasaki
authors.forename: Y
authors.initials: Y
authors.lastname: Ikejiri
authors.forename: T
authors.initials: T
authors.lastname: Imamura
authors.forename: T
authors.initials: T
authors.lastname: Shimomura
authors.forename: M
authors.initials: M
authors.lastname: Ikeda
authors.forename: H
authors.initials: H
authors.lastname: Yamashita
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000523:psychology*; D001923:Brain Chemistry / Q000502:physiology*; D003702:Delusions / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000523:psychology*; D005260:Female; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D019275:Radiopharmaceuticals; D014055:Tomography, Emission-Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D005947:Glucose