Regulation of gene expression by trans-synaptic activity: a role for the transcription factor NF-kappa B.
Earlier studies in the sympathetic ganglion have led to the proposal that adaptation of transcription to trans-synaptic activity is controlled by a signal transduction pathway featuring a transcription factor which translocates to the nucleus upon its release from the post-synaptic membrane by after-hyperpolarization. In light of recent progress, it is proposed here that NF-kappa B constitutes the postulated transcription factor.
Gisiger
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Département de Pathologie et Biologie cellulaire, Université de Montréal, Québec, Canada.
D000222:Adaptation, Physiological; D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology*; D016328:NF-kappa B / Q000502:physiology*; D009474:Neurons / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis; D015398:Signal Transduction / Q000502:physiology*; D013569:Synapses / Q000502:physiology*
D016328:NF-kappa B; D012313:RNA