title: Effect of different drugs on end-tidal carbon dioxide during rodent CPR.
abstract: The purpose of this study was to investigate the effect of non-adrenergic agents on cardiopulmonary resuscitation (CPR) and end-tidal CO2 (ETCO2) during CPR in a rodent model. Our results suggested that: 1) coronary perfusion pressure (CPP) after drugs infusion was increased significantly by methoxamine, arginine vasopresin (AVP) and angiotension-II (ANG-II), but not by endothelin-1 (ET-1); 2) ETCO2 prior to defibrillation was decreased significantly by a pure alpha 1 adrenergic agents, methoxamine and were increased significantly by non-adrenergic agents, ANG-II and ET-1 during rodent CPR; 3) a significant positive correlation between ETCO2 and CPP was observed in AVP group, suggesting that AVP have little effect on pulmonary circulation; and 4) methoxamine, AVP and ANG-II have similar effect on resuscitability during rodent CPR.
authors.affiliation: Department of Thoracic and Cardiac Surgery, Tongji Hospital, Tongji Medical University, Wuhan.
authors.forename: T
authors.initials: T
authors.lastname: Pan
authors.forename: S
authors.initials: S
authors.lastname: Zhou
authors.forename: W
authors.initials: W
authors.lastname: Studer
authors.forename: M
authors.initials: M
authors.lastname: von Planta
authors.forename: D
authors.initials: D
authors.lastname: Scheidegger
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology; D002245:Carbon Dioxide / Q000378:metabolism*; D002302:Cardiac Output / Q000187:drug effects; D016887:Cardiopulmonary Resuscitation; D008297:Male; D008729:Methoxamine / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013990:Tidal Volume / Q000187:drug effects*; D014662:Vasoconstrictor Agents / Q000494:pharmacology
chemical_list: D000316:Adrenergic alpha-Agonists; D014662:Vasoconstrictor Agents; D000804:Angiotensin II; D001127:Arginine Vasopressin; D002245:Carbon Dioxide; D008729:Methoxamine