Structure and chromosomal mapping of the TNF-alpha inducible endothelial protein 1 (Edp1) gene in the mouse.
EDP1 was identified as a human gene activated transcriptionally by tumour necrosis factor alpha in endothelial cells. Here we have characterised the mouse Edp1 gene. We show that the gene encodes a highly conserved protein and describe its intron/exon structure. The presence of related genes in the sequence databases suggests that Edp1 is part of a gene family. Fine mapping of the gene in the mouse genome indicates that, as expected from its location on human chromosome 17, the mouse Edp1 gene maps to mouse chromosome 11. However, surprisingly, the gene does not map to the expected region of mouse chromosome 11 suggesting that a change in the order of genes has occurred within a conserved linkage group.
Swift
S
S
Section of Gene Function and Regulation, Chester Beatty Laboratories, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK.
Blackburn
C
C
Morahan
G
G
Ashworth
A
A
D048868:Adaptor Proteins, Signal Transducing; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D016384:Consensus Sequence; D017124:Conserved Sequence; D008040:Genetic Linkage; D005819:Genetic Markers; D016678:Genome; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D051379:Mice / Q000235:genetics*; D008969:Molecular Sequence Data; D005810:Multigene Family; D014176:Protein Biosynthesis; D011506:Proteins / Q000737:chemistry / Q000235:genetics*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D048868:Adaptor Proteins, Signal Transducing; D005819:Genetic Markers; D047908:Intracellular Signaling Peptides and Proteins; D011506:Proteins; C115968:TNFAIP1 protein, human; C485474:Tnfaip1 protein, mouse; D014409:Tumor Necrosis Factor-alpha