Checkpoints on the road to mitosis.
Eukaryotic organisms use cell-cycle checkpoints to ensure that nuclear division is restrained while DNA is undergoing replication or repair. Recent studies of the fission yeast Schizosaccharomyces pombe have illuminated these checkpoint mechanisms. These investigations have connected checkpoint proteins with central elements of the mitotic-control machinery.
Russell
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Dept of Molecular Biology, Scripps Research Institute, La Jolla, CA 92037, USA. prussell@scripps.edu
D048948:14-3-3 Proteins; D000818:Animals; D000071877:Checkpoint Kinase 1; D004260:DNA Repair; D004261:DNA Replication; D006801:Humans; D008938:Mitosis / Q000502:physiology*; D008954:Models, Biological; D010710:Phosphates / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D012568:Schizosaccharomyces / Q000378:metabolism; D014446:Tyrosine 3-Monooxygenase
D048948:14-3-3 Proteins; D010710:Phosphates; D011506:Proteins; D014446:Tyrosine 3-Monooxygenase; D011494:Protein Kinases; D000071877:Checkpoint Kinase 1