Effects of antiallergic drugs on histamine release from rat peritoneal mast cells induced by bradykinin.
Effects of antiallergic drugs on bradykinin-induced histamine release and intracellular Ca2+ release from peritoneal mast cells were studied in rats. Bradykinin caused a concentration-dependent histamine release as well as Ca2+ release from the intracellular Ca store of peritoneal mast cells. Antiallergic drugs used in this study showed an inhibition of not only histamine release but also Ca2+ release. The Ca2+ release from the intracellular Ca store induced by bradykinin was more sensitive to antiallergic drugs than histamine release from mast cells. Mequitazine and terfenadine caused potent inhibitory effects on both responses, whereas effects of ketotifen and cromolyn sodium were relatively weak. In conclusion, histamine release from mast cells and intracellular C2+ release induced by bradykinin were inhibited by antiallergic drugs similar to those induced by substance P and compound 48/80.
Sugimoto
Y
Y
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Japan.
Tarumi
T
T
Zhao
Q E
QE
Fujii
Y
Y
Kamei
C
C
D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D001920:Bradykinin / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism*; D006636:Histamine Release / Q000187:drug effects*; D020128:Inhibitory Concentration 50; D008297:Male; D008407:Mast Cells / Q000187:drug effects* / Q000378:metabolism; D010640:Phenothiazines / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D016593:Terfenadine / Q000494:pharmacology
D018926:Anti-Allergic Agents; D010640:Phenothiazines; D016593:Terfenadine; D001920:Bradykinin; D002118:Calcium; C006069:mequitazine