title: Flavonoids and lignans from Virola surinamensis twigs and their in vitro activity against Trypanosoma cruzi.
abstract: Dichloromethane extracts from twigs of Virola surinamensis (Myristicaceae) showed in vitro trypanosomicidal activity against trypomastigote form of Trypanosoma cruzi. The extract, fractionated by preparative circular chromatography and preparative high-performance liquid chromatography yielded two steroids, two lignans, five flavonoids, and one polyketide. Among the isolated compounds, the lignans presented the highest trypanosomicidal activity.
authors.forename: N P
authors.initials: NP
authors.lastname: Lopes
authors.forename: P
authors.initials: P
authors.lastname: Chicaro
authors.forename: M J
authors.initials: MJ
authors.lastname: Kato
authors.forename: S
authors.initials: S
authors.lastname: Albuquerque
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D014349:Trypanosoma cruzi / Q000187:drug effects*
chemical_list: D000981:Antiprotozoal Agents; D005419:Flavonoids; D017705:Lignans