Central diabetes insipidus with spontaneous remission. A case report.
We report a case of central diabetes insipidus with spontaneous remission 8 months after clinical beginning of the disease. A 20 years-old man developed polydipsia and polyuria in October 1994. A water deprivation study showed a defect in the urine concentrating function, which was corrected by vasopressine. A Magnetic Resonance imaging of the skull revealed a thickening of the pituitary stalk. His condition was well controlled by nasal DDAVP administration and 6 months later patient reduced spontaneously medication dose without clinical worsening. 8 months after clinical beginning, patient has become completely free from the need for medication to control clinical symptoms and urine concentrating function, as demonstrated by a re-evaluation study with water deprivation. A control Magnetic Resonance showed the regression of stalk enlargement. The clinical and radiological features of this case are discussed.
Martini
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Cattedra di Medicina Interna (OPD), Istituto di Patologia Medica, Università, Siena.
Filosomi
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Valenti
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Lunghetti
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Pallavicino
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Nuti
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D000328:Adult; D001921:Brain / Q000473:pathology; D003919:Diabetes Insipidus / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011141:Polyuria / Q000188:drug therapy / Q000209:etiology; D012075:Remission, Spontaneous; D012076:Renal Agents / Q000627:therapeutic use; D014667:Vasopressins / Q000627:therapeutic use
D012076:Renal Agents; D014667:Vasopressins