title: [Disturbance of the normal cell cycle by T antigens of SV40 viruses and JC cause some tumors].
abstract: The mechanism that may lead to tumor formation in SV40 or JCV infected tissues based on previously reported interactions between T antigens and two factors (p53 and pRb) controlling cell cycle has been discussed. p53 is a known tumor suppressor protein that delays S phase entry causing cell arrest in G1 phase or apoptosis when the DNA damage occurs. Phosphorylation of pRB releases E2F family proteins that activate genes encoding S phase promoting factors. Binding of T antigens to pRB induces tumor formation, whereas tumor proliferation requires knockout of p53 activity.
authors.affiliation: Center for NeuroVirology and NeuroOncology, Allegheny University of the Health Sciences, Philadelphia, USA.
authors.forename: B
authors.initials: B
authors.lastname: Kryńska
authors.forename: J
authors.initials: J
authors.lastname: Lewin-Kowalik
authors.forename: A L
authors.initials: AL
authors.lastname: Sieroń
mesh_terms: D000818:Animals; D000952:Antigens, Polyomavirus Transforming / Q000276:immunology*; D002453:Cell Cycle / Q000235:genetics; D004273:DNA, Neoplasm / Q000032:analysis; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007577:JC Virus / Q000276:immunology*; D009369:Neoplasms / Q000473:pathology* / Q000821:virology*; D013539:Simian virus 40 / Q000276:immunology*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D000952:Antigens, Polyomavirus Transforming; D004273:DNA, Neoplasm; D016159:Tumor Suppressor Protein p53