Regulation of glucose utilization in yeast.
Our understanding of the regulatory mechanisms controlling the glucose response in yeast has advanced in the past year. Two transporter-like proteins have been shown to function as glucose sensors in a pathway for glucose induction of transporter genes. Our understanding of the glucose repression mechanism has been augmented by studies of the Snf1 protein kinase, the Mig1 repressor, and the role of Snf1 in inhibiting Mig1 and regulating activators. DNA microarrays have been used to assess glucose-regulated gene expression.
Carlson
M
M
Department of Genetics and Development, Columbia University, HHSC 922, Box 136, 701 West 168th Street, New York, New York 10032, USA. mbc1@columbia.edu
D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D005656:Fungal Proteins / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D005947:Glucose / Q000378:metabolism*; D008954:Models, Biological; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins; D015534:Trans-Activators / Q000378:metabolism
D004271:DNA, Fungal; D004268:DNA-Binding Proteins; D005656:Fungal Proteins; C085976:MIG1 protein, S cerevisiae; D012097:Repressor Proteins; D029701:Saccharomyces cerevisiae Proteins; D015534:Trans-Activators; C071570:SNF1-related protein kinases; D017346:Protein Serine-Threonine Kinases; D005947:Glucose