title: Signal profile measurements of single- and double-volume acquisitions with image-selected in vivo spectroscopy for 31P magnetic resonance spectroscopy.
abstract: The volume-selection performance was studied for single- and double-volume-of-interest (VOI) acquisition with the volume-selection method image-selected in vivo spectroscopy for 31P magnetic resonance spectroscopy. High-resolution signal profiles were measured using a phantom simulating a brain. Inside the phantom there was a small, remotely controlled, movable signal source filled with ortho-phosphoric acid. Signal profiles of the VOI were measured in three perpendicular directions for 1VOI (single VOI) and 2VOI (double VOI) acquisition. The measured signal profiles for both acquisitions were very similar, but they showed a discrepancy with regard to the intended VOI (iVOI). The transition regions were on average 3.8 mm and the average full width at half maximum of the signal profile was 30 mm for an iVOI size of 30*30*30 (mm3). No displacement was observed in the signal profiles. To avoid overlapping signal profiles, the minimum separation between two iVOIs was found to be 10 mm in our magnetic resonance (MR) system. A substantial negative signal contribution from regions outside the iVOI was measured in the y-direction for 1VOI acquisition and one of the two VOIs in 2VOI acquisition. The other VOI in 2VOI acquisition exhibited only minor contamination. The measurements presented underline the importance of detailed knowledge on the volume selection performance in in vivo magnetic resonance spectroscopy.
authors.affiliation: Department of Radiation Physics, Göteborg University, Sahlgrenska University Hospital, Sweden. Maria.Ljungberg@radfys.gu.se
authors.forename: M
authors.initials: M
authors.lastname: Ljungberg
authors.forename: G
authors.initials: G
authors.lastname: Starck
authors.forename: B
authors.initials: B
authors.lastname: Vikhoff-Baaz
authors.forename: E
authors.initials: E
authors.lastname: Forssell-Aronsson
authors.forename: M
authors.initials: M
authors.lastname: Alpsten
authors.forename: S
authors.initials: S
authors.lastname: Ekholm
mesh_terms: D001921:Brain / Q000378:metabolism; D003198:Computer Simulation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D019047:Phantoms, Imaging; D010756:Phosphoric Acids / Q000032:analysis; D010759:Phosphorus Isotopes; D015203:Reproducibility of Results
chemical_list: D010756:Phosphoric Acids; D010759:Phosphorus Isotopes; C030242:phosphoric acid