title: 2-Azetidinone cholesterol absorption inhibitors: increased potency by substitution of the C-4 phenyl ring.
abstract: SAR studies directed towards the optimization of 2-azetidinone cholesterol absorption inhibitors led to the discovery of 11a, the most potent cholesterol absorption inhibitor yet identified.
authors.affiliation: Schering-Plough Research Institute, Kenilworth, NJ 07033-0539, USA.
authors.forename: W D
authors.initials: WD
authors.lastname: Vaccaro
authors.forename: R
authors.initials: R
authors.lastname: Sher
authors.forename: H R
authors.initials: HR
authors.lastname: Davis
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000737:chemistry* / Q000494:pharmacology*; D001384:Azetidines / Q000737:chemistry / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D006224:Cricetinae; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013329:Structure-Activity Relationship
chemical_list: C116379:2-azetidinone; D000924:Anticholesteremic Agents; D001384:Azetidines; D002784:Cholesterol