Urinary deoxypyridinoline is a useful biochemical bone marker for the management of postmenopausal osteoporosis.
Most medical treatment of postmenopausal osteoporosis are inhibitors of bone resorption and urinary deoxypyridinoline (D-Pyr) has been shown to be a reliable indicator of bone resorption. Fifty-one healthy women were divided into four groups. Group A: premenopausal women (n = 10), Group B: postmenopausal women, no osteoporosis, not on hormone replacement therapy (HRT) (n = 14), Group C: postmenopausal women, osteoporotic, not on HRT (n = 12), and Group D: postmenopausal women on HRT (n = 15). Fasting urine was collected and sampled for D-Pyr using Pyrilinks-D Kit-(Metra Biosystems). Urinary D-Pyr was calculated in nM/creatinine mM. There was a significant difference between premenopausal and postmenopausal urinary D-Pyr showing a higher value of D-Pyr during menopause. Urinary D-Pyr results of postmenopausal women on HRT and premenopausal women showed no difference. Hence D-Pyr may be useful for the monitoring of hormonal treatment of postmenopausal bone loss.
Yu
S L
SL
Department of Obstetrics and Gynaecology, Singapore General Hospital.
Ho
L M
LM
Lim
B C
BC
Sim
M L
ML
D000328:Adult; D000596:Amino Acids / Q000652:urine*; D015415:Biomarkers / Q000652:urine; D015519:Bone Density; D001862:Bone Resorption / Q000652:urine; D001842:Bone and Bones / Q000378:metabolism*; D005260:Female; D006801:Humans; D007118:Immunoassay / Q000379:methods; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000652:urine*; D017698:Postmenopause / Q000652:urine; D017697:Premenopause / Q000652:urine; D015203:Reproducibility of Results; D018709:Statistics, Nonparametric
D000596:Amino Acids; D015415:Biomarkers; C036020:deoxypyridinoline