title: Changes in bone mineral density after orchidectomy and hormone replacement therapy in individuals with androgen insensitivity syndrome.
abstract: Changes in bone mineral density (BMD) after orchidectomy and after hormone replacement therapy were reported in two patients with complete androgen insensitivity syndrome (AIS). Diagnosis of AIS was made by clinical features and confirmed by the presence of 46,XY karyotype and the presence of testis component in the removed gonads. BMD at the lumbar spine and at three sites of the femur was measured by dual energy X-ray absorptiometry (DXA). The Z scores of the lumbar spine BMD before orchidectomy were -0.8 and -3.1, confirming that patients with AIS have low BMD and that androgen plays an important role in bone mineralization in 46,XY individuals. Castration reduced BMD, but treatment with daily doses of 1.25 mg of conjugated oestrogen and 10 mg of medroxyprogesterone acetate increased BMD. These results indicate that both oestrogen and androgen play an important role in balancing BMD in men.
authors.affiliation: Department of Obstetrics and Gynecology, Gunma University School of Medicine, Maebashi, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Mizunuma
authors.forename: M
authors.initials: M
authors.lastname: Soda
authors.forename: H
authors.initials: H
authors.lastname: Okano
authors.forename: I
authors.initials: I
authors.lastname: Kagami
authors.forename: S
authors.initials: S
authors.lastname: Miyamoto
authors.forename: M
authors.initials: M
authors.lastname: Ohsawa
authors.forename: Y
authors.initials: Y
authors.lastname: Ibuki
mesh_terms: D000328:Adult; D013734:Androgen-Insensitivity Syndrome / Q000235:genetics / Q000378:metabolism* / Q000628:therapy; D015519:Bone Density / Q000187:drug effects / Q000502:physiology; D004958:Estradiol / Q000097:blood; D015914:Estrogen Replacement Therapy; D004967:Estrogens / Q000627:therapeutic use; D006801:Humans; D008297:Male; D017258:Medroxyprogesterone Acetate / Q000627:therapeutic use; D009919:Orchiectomy / Q000009:adverse effects; D013739:Testosterone / Q000097:blood; D013997:Time Factors
chemical_list: D004967:Estrogens; D013739:Testosterone; D004958:Estradiol; D017258:Medroxyprogesterone Acetate