title: Lansoprazole and omeprazole in the prevention of relapse of reflux oesophagitis: a long-term comparative study.
abstract: BACKGROUND
  Proton pump inhibitors are superior to H2-receptor antagonists in the prevention of relapse of oesophagitis, but few data directly compare the relative efficacies of lansoprazole and omeprazole in preventing oesophagitis relapse over a prolonged period.
  
  
  METHODS
  Patients with healed Grade II, III or IV oesophagitis were treated with lansoprazole 30 mg o.d. or omeprazole 20 mg o.d. for 48 weeks. Endoscopy and symptom assessment were performed after 12. 24 and 48 weeks of treatment and an additional symptom assessment 36 weeks after starting treatment.
  
  
  RESULTS
  Intention-to-treat analysis included 248 patients (lansoprazole n = 126, omeprazole n = 122). Comparison of time to endoscopic and/or symptomatic relapse revealed no difference between the treatments. There was no significant difference between treatments with respect to the proportion of patients in whom endoscopic and/or symptomatic relapse was reported (lansoprazole 12/126 (9.5%), omeprazole 11/122 (9.0%)). No difference between the treatments in either the number or severity of adverse events was reported.
  
  
  CONCLUSIONS
  Continuous treatment with either lansoprazole 30 mg or omeprazole 20 mg is effective in preventing the relapse of oesophagitis over a 48-week period in a majority of patients. Both treatments exhibit a similar side-effect profile.
authors.affiliation: Department of Medicine, Bollnäs Hospital, Sweden. lasse.carling@bs.lg.se
authors.forename: L
authors.initials: L
authors.lastname: Carling
authors.forename: C K
authors.initials: CK
authors.lastname: Axelsson
authors.forename: H
authors.initials: H
authors.lastname: Forssell
authors.forename: A
authors.initials: A
authors.lastname: Stubberöd
authors.forename: K
authors.initials: K
authors.lastname: Kraglund
authors.forename: O
authors.initials: O
authors.lastname: Bonnevie
authors.forename: P
authors.initials: P
authors.lastname: Ekström
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000293:Adolescent; D000328:Adult; D000368:Aged; D004942:Esophagitis, Peptic / Q000517:prevention & control*; D005260:Female; D006801:Humans; D064747:Lansoprazole; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D055502:Secondary Prevention; D013997:Time Factors
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D064747:Lansoprazole; D009853:Omeprazole