title: Duration of antiviral prophylaxis during nursing home outbreaks of influenza A: a comparison of 2 protocols.
abstract: BACKGROUND
  We performed a randomized trial of 2 protocols guiding the duration of antiviral chemoprophylaxis during outbreaks of influenza A in a rural, 700-bed nursing home for veterans and their spouses with 14 nursing units in 4 buildings.
  
  
  METHODS
  Half of all residents volunteered to participate. Nursing units were randomized, and the effectiveness of short-term (minimum, 14 days and 7 days without the onset of a case in the building) vs long-term (minimum, 21 days and 7 days without the onset of a case in the 4-building facility) prophylaxis was compared using amantadine hydrochloride in the influenza seasons of 1991-1992 and 1993-1994 and rimantadine hydrochloride in the influenza season of 1994-1995. A "case" is defined as an incident of a respiratory tract illness and the isolation of an influenza virus organism. We compared the number of cases after the discontinuation of short- vs long-term chemoprophylaxis. Prospective surveillance identified residents with new respiratory tract symptoms, and specimens for viral cultures were obtained even in the absence of temperature elevation.
  
  
  RESULTS
  We documented influenza A virus activity during 3 seasons (32, 68, and 12 patients, respectively). During the 1991-1992, 1993-1994, and 1994-1995 influenza seasons, the patients on 11 floors were assigned to receive short-term chemoprophylaxis and those on 10 floors were assigned to long-term chemoprophylaxis. Only in 1993-1994 did chemoprophylaxis extend beyond 14 or 21 days when new cases continued beyond 14 days. Amantadine-resistant strains were circulating at that time. None of the participants in the prospective, controlled study had influenza develop after the termination of short- or long-term chemoprophylaxis.
  
  
  CONCLUSIONS
  Antiviral chemoprophylaxis can be administered for the longer duration of 14 days or, in the absence of new culture-confirmed illness in the nursing building, for 7 days.
authors.affiliation: Office of the Medical Diector, Wisconsin Veterans Home, King, USA.
authors.forename: P J
authors.initials: PJ
authors.lastname: Drinka
authors.forename: S
authors.initials: S
authors.lastname: Gravenstein
authors.forename: M
authors.initials: M
authors.lastname: Schilling
authors.forename: P
authors.initials: P
authors.lastname: Krause
authors.forename: B A
authors.initials: BA
authors.lastname: Miller
authors.forename: P
authors.initials: P
authors.lastname: Shult
mesh_terms: D000368:Aged; D000998:Antiviral Agents / Q000008:administration & dosage*; D004196:Disease Outbreaks; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D009980:Influenza A virus; D007251:Influenza, Human / Q000453:epidemiology / Q000517:prevention & control* / Q000821:virology; D008297:Male; D008875:Middle Aged; D009735:Nursing Homes / Q000706:statistics & numerical data*; D011159:Population Surveillance; D011446:Prospective Studies; D012423:Rural Health; D014728:Veterans; D014922:Wisconsin
chemical_list: D000998:Antiviral Agents