Anti-lipid peroxidization effect of huangdan on chronic renal failure in rats.
The activity of superoxide dismutase (SOD) in renal cortex and erythrocytes, the level of lipid peroxidant (LPO) in plasma, renal function and morphology of leftover kidney were examined in rats. The results showed that Huangdan capsule could slow down the increase of BUN and Scr, promote the SOD activity in renal cortex and erythrocytes, reduce the level of LPO in plasma and delay the renal pathological changes in 5/6 nephrectomized rats. The mechanism of Huangdan capsule's antiperoxidant effect, its effect on the renal pathological changes and relationship between the two effects were also discussed.
Zheng
J
J
Department of Traditional Chinese Medicine, Xiehe Hospital, Tongji Medical University, Wuhan.
Hong
S
S
Chen
S
S
Zhang
C
C
Chen
J
J
Zhou
S
S
D000818:Animals; D002214:Capsules; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D016166:Free Radical Scavengers / Q000494:pharmacology* / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000188:drug therapy / Q000378:metabolism*; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism*
D002214:Capsules; D004365:Drugs, Chinese Herbal; D016166:Free Radical Scavengers; D008054:Lipid Peroxides; D013482:Superoxide Dismutase