title: Sequence characterisation and expression of homeobox HOX A7 in the multi-potential erythroleukaemic cell line TF-1.
abstract: Homeobox gene expression was examined in the erythroleukaemic cell line TF-1. Expression of a number of HOX A, B and C genes, including HOX A7 was detected. Expression of this gene has not previously been reported in erythroleukaemic cell lines. A 2.1 kb full length cDNA of the HOX A7 gene was cloned. The predicted amino acid sequence C-terminal to the homeodomain consists of an alanine-rich region and a strongly negatively charged domain consisting entirely of aspartic and glutamic acid residues.
authors.affiliation: Department of Haematology, Institute of Clinical Science, The Queen's University of Belfast, Royal Victoria Hospital, Belfast BT12 6BA, UK.
authors.forename: M A
authors.initials: MA
authors.lastname: McIlhatton
authors.forename: P
authors.initials: P
authors.lastname: Bremner
authors.forename: M F
authors.initials: MF
authors.lastname: McMullin
authors.forename: A P
authors.initials: AP
authors.lastname: Maxwell
authors.forename: P C
authors.initials: PC
authors.lastname: Winter
authors.forename: T R
authors.initials: TR
authors.lastname: Lappin
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D018076:DNA, Complementary; D004921:Erythropoietin / Q000494:pharmacology; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D005801:Genes, Homeobox; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology; D018398:Homeodomain Proteins / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics*; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins; D016133:Polymerase Chain Reaction; D014407:Tumor Cells, Cultured
chemical_list: D018076:DNA, Complementary; C115962:HOXA7 protein, human; D018398:Homeodomain Proteins; D009363:Neoplasm Proteins; D004921:Erythropoietin; D016178:Granulocyte-Macrophage Colony-Stimulating Factor