title: The circadian variation of urinary N-acetyl-beta-D-glucosaminidase and gamma-glutamyl transpeptidase in clinically healthy cats.
abstract: The circadian variation of urinary N-acetyl-beta-D-glucosaminidase (NAG, EC 3.2.1.30) and gamma-glutamyl transpeptidase (gamma-GTP, EC 2.3.2.2) was evaluated in cats. Urine and blood were collected at 4-hr intervals from adult cats (3 males, 9 females) weighing between 2.6 and 5.0 kg. There was no circadian variation in the urine volume, creatinine clearance, creatinine excretion, NAG excretion or gamma-GTP excretion. The average NAG and gamma-GTP indices in the 4-hr urine were similar to those for the 24-hr urine. However, the variance for the 4-hr urine samples was higher than that of 24-hr urine. In conclusion, although 4-hr urine samples can be used to estimate 24-hr urinary enzyme excretion, short-term spot urine samples may cause increased variation in the enzyme index.
authors.affiliation: Teaching Animal Hospital, Kitasato University, Aomori, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Uechi
authors.forename: H
authors.initials: H
authors.lastname: Uechi
authors.forename: T
authors.initials: T
authors.lastname: Nakayama
authors.forename: Y
authors.initials: Y
authors.lastname: Wakao
authors.forename: T
authors.initials: T
authors.lastname: Ogasawara
authors.forename: K
authors.initials: K
authors.lastname: Takase
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
mesh_terms: D000118:Acetylglucosaminidase / Q000652:urine*; D000818:Animals; D002415:Cats / Q000652:urine*; D002940:Circadian Rhythm; D003404:Creatinine / Q000652:urine; D005260:Female; D007668:Kidney / Q000502:physiology; D008297:Male; D005723:gamma-Glutamyltransferase / Q000652:urine*
chemical_list: D003404:Creatinine; D005723:gamma-Glutamyltransferase; D000118:Acetylglucosaminidase