Predictors of lymphoma development in primary Sjögren's syndrome.
OBJECTIVE
To determine the clinical and laboratory predictors of lymphoma development in primary Sjögren's syndrome (pSS).


METHODS
Seventy-two patients with pSS were studied. Demographic data, clinical features, serum gamma-globulin levels, autoantibodies, and HLA status were reviewed. For statistical analysis, Mann-Whitney U-test, Fisher's exact test, logistic regression analysis, Kaplan-Meier method, and log-rank tests were applied.


RESULTS
Five patients developed a distinct non-Hodgkin's lymphoma of mucosa-associated lymphoid tissue (MALT). A history of swollen salivary glands, lymphadenopathy, and leg ulcers predicted lymphoma development.


CONCLUSIONS
Patients with pSS are at increased risk of lymphoma development, and those who have the above risk factors must be carefully observed.
Sutcliffe
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N
Centre for Rheumatology/Bloomsbury Rheumatology Unit, Department of Medicine, University College London.
Inanc
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M
Speight
P
P
Isenberg
D
D
D000328:Adult; D017668:Age of Onset; D000368:Aged; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D015995:Prevalence; D012189:Retrospective Studies; D012859:Sjogren's Syndrome / Q000401:mortality*; D016019:Survival Analysis