title: Chlamydia pneumoniae infection in patients with diffuse panbronchiolitis and COPD.
abstract: OBJECTIVE
  To determine the possible association of Chlamydia pneumoniae infection with diffuse panbronchiolitis (DPB) and with COPD.
  
  
  METHODS
  Prospective case-control study.
  
  
  METHODS
  Division of Respiratory Diseases, Kawasaki Medical School Hospital.
  
  
  METHODS
  Fifteen DPB and 77 COPD patients who had acute exacerbations of respiratory conditions and 35 and 120 control subjects, respectively, matched for age, sex, and smoking status.
  
  
  RESULTS
  Nasopharyngeal swabs and paired serum samples were obtained from all patients and control subjects for isolation and antibody testing of C pneumoniae. C pneumoniae was isolated from one DPB patient and from no COPD patients or control subjects. Serologic evidence of acute C pneumoniae infection was observed in one DPB patient (6.7%) and six COPD patients (7.8%). The prevalence and mean titer of C pneumoniae IgG and IgA antibodies were significantly higher in COPD patients than in control subjects (p<0.001). However, no such differences were observed between DPB patients and control subjects.
  
  
  CONCLUSIONS
  This study showed that C pneumoniae infection may be associated with acute exacerbations of COPD and that chronic C pneumoniae infection is common in COPD but not in DPB.
authors.affiliation: Department of Medicine, Kawasaki Medical School, Kurashiki City, Okayama, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Miyashita
authors.forename: Y
authors.initials: Y
authors.lastname: Niki
authors.forename: M
authors.initials: M
authors.lastname: Nakajima
authors.forename: H
authors.initials: H
authors.lastname: Kawane
authors.forename: T
authors.initials: T
authors.lastname: Matsushima
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000032:analysis; D001988:Bronchiolitis / Q000150:complications* / Q000382:microbiology; D016022:Case-Control Studies; D002690:Chlamydia Infections / Q000150:complications* / Q000382:microbiology; D016993:Chlamydophila pneumoniae / Q000276:immunology / Q000302:isolation & purification*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D008173:Lung Diseases, Obstructive / Q000150:complications* / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D009305:Nasopharynx / Q000382:microbiology; D011446:Prospective Studies
chemical_list: D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M