title: Effects of creatine monohydrate ingestion in sedentary and weight-trained older adults.
abstract: To investigate the effects of an oral creatine supplementation in older adults, 32 elderly subjects (67-80 years; 16 females, 16 males) were randomly assigned to four equivalent subgroups (control-creatine; control-placebo; trained-creatine; trained-placebo) based on whether or not they took part in an 8-week strength training programme and an 8-week oral creatine monohydrate creatine supplementation programme. The strength training programme consisted of three sets of eight repetitions at 80% of one-repetition maximum, for leg press, leg extension and chest press, 3 days a week. The 52-day supplementation programme consisted of 20 g of creatine monohydrate (or glucose) and 8 g of glucose per day for the initial 5 days followed by 3 g of creatine monohydrate (or glucose), and 2 g of glucose per day. Prior to and after the training and supplementation periods, body mass, body fat, lower limb muscular volume, 1-, 12-repetitions maxima and isometric intermittent endurance tests for leg press, leg extension and chest press were determined. In all groups, no significant changes in anthropometric parameters were observed. For all movements, the increases in 1- and 12-repetitions maxima were greater (P < 0.02) in trained than control subjects. No significant interactions (supplementation/training/time) were observed for the 1-, 12-repetitions maxima, and the isometric intermittent endurance, whatever the movement considered. We conclude that oral creatine supplementation does not provide additional benefits for body composition, maximal dynamical strength, and dynamical and isometric endurances of healthy elderly subjects, whether or not it is associated with an effective strength training.
authors.affiliation: Department of Physiology, Medical School, University of Nice-Sophia Antipolis, France.
authors.forename: S
authors.initials: S
authors.lastname: Bermon
authors.forename: P
authors.initials: P
authors.lastname: Venembre
authors.forename: C
authors.initials: C
authors.lastname: Sachet
authors.forename: S
authors.initials: S
authors.lastname: Valour
authors.forename: C
authors.initials: C
authors.lastname: Dolisi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D000886:Anthropometry; D003401:Creatine / Q000008:administration & dosage*; D004032:Diet; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D018763:Muscle Fatigue / Q000187:drug effects*; D009747:Nutritional Physiological Phenomena; D010349:Patient Compliance; D014556:Urine; D014891:Weight Lifting / Q000502:physiology*
chemical_list: D003401:Creatine