[Effects of lead on the release of glutamate neurotransmitter in rat hippocampal slices].
Effects of lead on the release of glutamate neurotransmitter were observed in rat hippocampal slices in vitro to study its neurobiological mechanism of lead-induced impairment in learning and memory function. Results showed that exposure to 3.1 to 50.0 mumol/L of lead could cause a dose-dependent increase in spontaneous release of 3H-DL-glutamic acid in hippocampal slices by 23.2% to 66.2% in the absence of calcium. However, in the presence of calcium, spontaneous release of 3H-DL-glutamic acid decreased by 22.6% to 55.3% with increase of exposure to lead from 1.0 to 50.0 mumol/L, and the release induced by potassium increased by 89.3% to 332.1% with a dose-response relationship. It indicated that exposure to lead could interfere with spontaneous and induced release of glutamate transmitter.
Zhang
H
H
Department of Toxicology, Chinese Academy of Preventive Medicine, Beijing.
Zhao
X
X
Song
L
L
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D018698:Glutamic Acid / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism*; D066298:In Vitro Techniques; D007854:Lead / Q000633:toxicity*; D007858:Learning / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D007854:Lead; D018698:Glutamic Acid; D011188:Potassium; D002118:Calcium