[Total intravenous anesthesia with propofol is advantageous than thiopental-sevoflurane anesthesia in the recovery phase].
A randomized, prospective and multi-institutional study was performed to investigate whether different anesthetic methods affected differently the quality of recovery from anesthesia. Two hundred and eleven patients were allocated to one of two groups; total intravenous anesthesia (TIVA) with propofol and fentanyl (group P, n = 107) and general anesthesia with thiopental, sevoflurane and nitrous oxide (group TS, n = 104). The rapidity of emergence from anesthesia and postoperative incidence of nausea, vomiting, and headache were compared between the two groups. The group P showed significantly shorter emergence times for verbal command responses (7.4 +/- 5.6 min), extubation (10.0 +/- 6.0 min) and orientation (13.1 +/- 7.8 min) than the group TS (9.1 +/- 5.0 min, 11.7 +/- 6.2 min, 16.4 +/- 7.9 min, respectively). The postoperative incidence of vomiting was not significantly different between the two groups (3.7% in the group P and 9.6% in the group TS), but the postoperative incidences of nausea and headache were significantly lower in the group P compared with the group TS (10.3%, 17.8%, respectively in the group P and 34.6%, 29.8%, respectively in the group TS). We conclude that TIVA with propofol is advantageous than thiopental-sevoflurane anesthesia in the recovery phase.
Matsumoto
H
H
Department of Anesthesiology, Kansai Medical University, Moriguchi.
Shingu
K
K
Numata
K
K
Ogura
S
S
Hanaoka
K
K
Ito
H
H
Kugimiya
T
T
Kazama
T
T
Ikeda
K
K
Murakawa
M
M
Mori
K
K
Mashimo
T
T
Yoshiya
I
I
Morio
M
M
Nakao
M
M
Sato
A
A
D000328:Adult; D000368:Aged; D000762:Anesthesia Recovery Period; D000768:Anesthesia, General; D000771:Anesthesia, Intravenous; D019162:Anesthetics, Combined; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D005260:Female; D005283:Fentanyl; D006801:Humans; D015994:Incidence; D008297:Male; D008738:Methyl Ethers; D008875:Middle Aged; D009609:Nitrous Oxide; D011183:Postoperative Complications / Q000453:epidemiology; D015742:Propofol; D011446:Prospective Studies; D000077149:Sevoflurane; D013874:Thiopental
D019162:Anesthetics, Combined; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D008738:Methyl Ethers; D000077149:Sevoflurane; D013874:Thiopental; D009609:Nitrous Oxide; D005283:Fentanyl; D015742:Propofol