Acute respiratory failure due to gentamicin aerosolization.
We report a paradoxical episode of near-fatal bronchoconstriction which occurred in an adult bronchiectatic subject, with chronic Pseudomonas aeruginosa airways colonization, immediately after his first inhalation of a gentamicin solution. This adverse reaction may be due to the gentamicin itself, the physical properties of the solution, or preservatives in the (commercially available) gentamicin solution.
Melani
A S
AS
Dept of Pneumology, L. Armanni Hospital, Azienda Ospedaliera Trentina, Arco di Trento, Italy.
Di Gregorio
A
A
D000280:Administration, Inhalation; D000336:Aerosols; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001987:Bronchiectasis / Q000150:complications; D005839:Gentamicins / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D011552:Pseudomonas Infections / Q000150:complications / Q000188:drug therapy; D012131:Respiratory Insufficiency / Q000139:chemically induced*; D012141:Respiratory Tract Infections / Q000150:complications / Q000188:drug therapy
D000336:Aerosols; D000900:Anti-Bacterial Agents; D005839:Gentamicins