title: Pharmacokinetic parameters and milk concentrations of ketoprofen after administration as a single intravenous bolus dose to lactating goats.
abstract: Six clinically normal lactating does were administered ketoprofen (2.2 mg/kg intravenously (i.v.)). Blood and milk samples were collected prior to and for 24 h after drug administration. Drug concentrations in serum and milk were determined by high performance liquid chromatography. Pharmacokinetic parameters from each goat were combined to obtain mean estimates (mean +/- SD) of half-life of elimination (t1/2beta) of 0.32 +/- 0.14 h, systemic clearance (Cl) of 0.74 +/- 0.12 L/kg x h, and volume of distribution at steady state (V(ss)) of 0.23 +/- 0.051 L/kg. In milk, ketoprofen was unmeasurable by the method employed (level of detection 25 ng/mL) for all samples.
authors.affiliation: Department of Food Animal and Equine Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Musser
authors.forename: K L
authors.initials: KL
authors.lastname: Anderson
authors.forename: K L
authors.initials: KL
authors.lastname: Tyczkowska
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006041:Goats / Q000502:physiology*; D007275:Injections, Intravenous; D007660:Ketoprofen / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007774:Lactation; D008892:Milk / Q000737:chemistry / Q000378:metabolism*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007660:Ketoprofen