title: Mutation involving cytochrome P450IID6 in two Japanese patients with neuroleptic malignant syndrome.
abstract: Cytochrome P450IID6 (CYP2D6) plays an important role in the hepatic metabolism of various psychotropic drugs. We detected a mutation of the CYP2D6 gene in two patients who previously had episodes of neuroleptic malignant syndrome (NMS). They were homozygous for a mutated CYP2D6J allele conferring a poor-metabolizer phenotype. Possession of this trait may contribute to susceptibility to NMS.
authors.affiliation: Department of Psychiatry, Yokohama City University School of Medicine, Yokohama, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Kawanishi
authors.forename: Y
authors.initials: Y
authors.lastname: Shimoda
authors.forename: J
authors.initials: J
authors.lastname: Fujimaki
authors.forename: H
authors.initials: H
authors.lastname: Onishi
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Hanihara
authors.forename: N
authors.initials: N
authors.lastname: Sugiyama
authors.forename: K
authors.initials: K
authors.lastname: Kosaka
mesh_terms: D000483:Alleles; D019943:Amino Acid Substitution; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000493:pharmacokinetics; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics* / Q000502:physiology; D004252:DNA Mutational Analysis; D020022:Genetic Predisposition to Disease; D006720:Homozygote; D006801:Humans; D008658:Inactivation, Metabolic / Q000235:genetics; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D008875:Middle Aged; D009459:Neuroleptic Malignant Syndrome / Q000201:enzymology / Q000235:genetics*; D017354:Point Mutation
chemical_list: D014150:Antipsychotic Agents; D019389:Cytochrome P-450 CYP2D6