[Hypoglycemic effect of Rhodiola sachalinensis A. Bor. polysaccharides: comparison of administration in different ways].
When Rhodiola sachalinensis polysaccharides A and B (RSP A and RSP B) were intraperitoneally injected to mice at dosages of 50 mg/kg and 100 mg/kg, the result showed that RSP B was the effective hypoglycemic ingredient of Rhodiola sachalinensis. When mice were administrated in different ways, it was shown that RSP B did not possess significant hypoglycemic effect through absorption in the instestines. However, RSP B does possess significant hypoglycemic effect if administrated subcutaneously, intramuscularly, intraperitoneally and intravenously.
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Jilin Provincial Academy of TCM and Materia Medica, Changehun.
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Wu
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Liu
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Ren
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D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D019684:Magnoliopsida / Q000737:chemistry; D008297:Male; D051379:Mice; D011134:Polysaccharides / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D007004:Hypoglycemic Agents; D011134:Polysaccharides