[Effect of adrenomedullin on mesenteric microvessels and microlymphatics in rat].
The dilatant effect of adrenomedullin (ADM), a novel peptide of 52 amino acids, on the mesenteric microvessels and microlymphatics was investigated under microscopic observation. 10(-6) mol/L ADM could also ameliorate alteration of the hemorheology induced by 10(-5) mol/L norepinephrine (NE) or 10(-7) mol/L endothelin (ET). However, this ameliorative response was markedly inhibited in the presence of NG-nitro-L-arginine (L-NNA), an inhibitor for production of nitric oxide.
Fan
G
G
Department of Pathophysiology, Zhangjiakou Medical College.
Niu
C Y
CY
Han
M
M
Zhang
J
J
Wei
Y J
YJ
Tang
S S
SS
Tang
J
J
D053607:Adrenomedullin; D000818:Animals; D002196:Capillaries / Q000187:drug effects; D016232:Endothelins / Q000494:pharmacology; D008208:Lymphatic System / Q000187:drug effects; D008297:Male; D008643:Mesentery / Q000098:blood supply*; D019335:Nitroarginine / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014665:Vasodilator Agents / Q000494:pharmacology*
D016232:Endothelins; D010455:Peptides; D014665:Vasodilator Agents; D053607:Adrenomedullin; D019335:Nitroarginine; D009638:Norepinephrine