title: Comparative pathogenesis of haemorrhagic enteritis virus (HEV) infection in turkeys and chickens.
abstract: The pathogenesis of haemorrhagic enteritis virus (HEV) infection in chickens 3-4 days post-infection was compared with that in turkeys. As expected, infected turkeys showed HEV-specific lesions that included enlargement and mottling of the spleen, as well as haemorrhagic enteritis. In infected chickens, only splenomegaly was observed. The number of HEV-infected cells in the spleen was significantly (P < 0.05) higher in the turkey than in the chicken. In both species, the immunohistochemical labelling of B-cell surface determinants was diminished and the splenic B-cell areas were undetectable after HEV infection. Infection with HEV resulted in an increase in nitric oxide production by macrophages in chickens but not in turkeys.
authors.affiliation: College of Veterinary Medicine, University of Minnesota, Saint Paul 55108, USA.
authors.forename: S
authors.initials: S
authors.lastname: Rautenschlein
authors.forename: M
authors.initials: M
authors.lastname: Suresh
authors.forename: U
authors.initials: U
authors.lastname: Neumann
authors.forename: J M
authors.initials: JM
authors.lastname: Sharma
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000032:analysis; D015703:Antigens, CD / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology; D002645:Chickens / Q000821:virology*; D004752:Coronavirus, Turkey / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity*; D004753:Enteritis, Transmissible, of Turkeys / Q000276:immunology / Q000473:pathology / Q000821:virology*; D006471:Gastrointestinal Hemorrhage / Q000276:immunology / Q000473:pathology / Q000821:virology; D007124:Immunoenzyme Techniques / Q000662:veterinary; D007963:Leukocytes, Mononuclear / Q000276:immunology / Q000473:pathology; D008264:Macrophages / Q000276:immunology; D009569:Nitric Oxide / Q000378:metabolism; D011201:Poultry Diseases / Q000276:immunology / Q000473:pathology / Q000821:virology*; D013047:Specific Pathogen-Free Organisms; D013158:Splenic Diseases / Q000276:immunology / Q000473:pathology / Q000821:virology; D014422:Turkeys / Q000821:virology*
chemical_list: D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000956:Antigens, Viral; D009569:Nitric Oxide