title: Diagnostic findings in endoscopic screening of superficial colorectal neoplasia: results from a prospective study.
abstract: BACKGROUND
  A prospective study was carried out to clarify the efficacy of an endoscopic screening program for detecting superficial colorectal neoplasias by color changes such as faint redness or discoloration, which have been described as a key finding of these lesions in the literature.
  
  
  METHODS
  We enrolled 716 consecutive cases in this study, but more than half of them did not reveal any abnormalities colonoscopically.
  
  
  RESULTS
  Of the 716 cases, 48 (7%) were examined by magnifying colonoscopy with a dye spraying technique, following the detection of superficial color changes. Sixteen neoplastic lesions (in 16 cases) were detected among the 48 cases and the detection rate was calculated as 2.2% (16/716) in the total number of cases and 33% (16/48) in those showing color abnormalities. Histologically, all of the 16 were adenomas. These neoplastic lesions were most frequent (52%; 11/21) in those showing faint redness in an oval shape, whereas 14 (94%) of the 15 lesions were non-specific in those showing faint redness with unclear margin.
  
  
  CONCLUSIONS
  These results may confirm the diagnostic utility of color abnormality, particularly faint redness in an oval shape, for endoscopic screening of superficial colorectal neoplasias.
authors.affiliation: Endoscopy Division, National Cancer Center Hospital East, Chiba, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Koba
authors.forename: S
authors.initials: S
authors.lastname: Yoshida
authors.forename: T
authors.initials: T
authors.lastname: Fujii
authors.forename: K
authors.initials: K
authors.lastname: Hosokawa
authors.forename: S H
authors.initials: SH
authors.lastname: Park
authors.forename: A
authors.initials: A
authors.lastname: Ohtsu
authors.forename: Y
authors.initials: Y
authors.lastname: Oda
authors.forename: K
authors.initials: K
authors.lastname: Muro
authors.forename: H
authors.initials: H
authors.lastname: Tajiri
authors.forename: T
authors.initials: T
authors.lastname: Hasebe
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000473:pathology; D003106:Colon / Q000473:pathology; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D008875:Middle Aged; D011446:Prospective Studies