Major histocompatibility complex genotype is associated with disease progression and virus load levels in a cohort of human immunodeficiency virus type 1-infected Caucasians and African Americans.
To assess the influence of HLA on AIDS-free survival, human immunodeficiency virus load, and CD4 cell counts, 91 Caucasian and 48 African-American seroprevalent men were typed for HLA classes I and II and TAP alleles. HLA associations with these markers were assessed by assigning sum integer scores based on 7 class I allele-TAP variants (+1) and 13 class I-class II-TAP combinations (-1) with different AIDS-free survival times found in a prior study. Subjects in both racial groups and combined with positive sum scores were less likely to have CD4 cell decline (P=.0004), to have increased virus burden (P=.014), and to develop AIDS (P=.034) in the follow-up period than were Caucasians and African Americans with scores of 0 or -1. These results confirm the reported associations of specific major histocompatibility complex genes with AIDS-free survival time in Caucasians and specifically extend them to African Americans and to two established markers of disease progression.
Mann
D L
DL
Immunogenetics Division, Department of Pathology, University of Maryland Medical System, Baltimore, MD 21201, USA. dmann001@umaryland.edu
Garner
R P
RP
Dayhoff
D E
DE
Cao
K
K
Fernández-Viña
M A
MA
Davis
C
C
Aronson
N
N
Ruiz
N
N
Birx
D L
DL
Michael
N L
NL
D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D018528:ATP-Binding Cassette Transporters / Q000235:genetics; D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics / Q000276:immunology* / Q000628:therapy; D044383:Black People / Q000235:genetics*; D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D018572:Disease-Free Survival; D005805:Genes, MHC Class I; D005802:Genes, MHC Class II; D014644:Genetic Variation; D005838:Genotype; D019302:HIV Envelope Protein gp160 / Q000627:therapeutic use; D006679:HIV Seropositivity / Q000235:genetics / Q000276:immunology / Q000628:therapy; D015528:HIV Seroprevalence; D015497:HIV-1; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics*; D008297:Male; D011994:Recombinant Proteins / Q000627:therapeutic use; D015996:Survival Rate; D019562:Viral Load; D044465:White People / Q000235:genetics*; D001741:Black or African American
D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D018528:ATP-Binding Cassette Transporters; D019302:HIV Envelope Protein gp160; D011994:Recombinant Proteins; C073119:TAP1 protein, human