title: Predictors of lymphoma development in primary Sjögren's syndrome.
abstract: OBJECTIVE
  To determine the clinical and laboratory predictors of lymphoma development in primary Sjögren's syndrome (pSS).
  
  
  METHODS
  Seventy-two patients with pSS were studied. Demographic data, clinical features, serum gamma-globulin levels, autoantibodies, and HLA status were reviewed. For statistical analysis, Mann-Whitney U-test, Fisher's exact test, logistic regression analysis, Kaplan-Meier method, and log-rank tests were applied.
  
  
  RESULTS
  Five patients developed a distinct non-Hodgkin's lymphoma of mucosa-associated lymphoid tissue (MALT). A history of swollen salivary glands, lymphadenopathy, and leg ulcers predicted lymphoma development.
  
  
  CONCLUSIONS
  Patients with pSS are at increased risk of lymphoma development, and those who have the above risk factors must be carefully observed.
authors.affiliation: Centre for Rheumatology/Bloomsbury Rheumatology Unit, Department of Medicine, University College London.
authors.forename: N
authors.initials: N
authors.lastname: Sutcliffe
authors.forename: M
authors.initials: M
authors.lastname: Inanc
authors.forename: P
authors.initials: P
authors.lastname: Speight
authors.forename: D
authors.initials: D
authors.lastname: Isenberg
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D015995:Prevalence; D012189:Retrospective Studies; D012859:Sjogren's Syndrome / Q000401:mortality*; D016019:Survival Analysis