[D-cycloserine is active in the adult mouse and inactive in the aged mouse, in the forced swim test].
The glycinergic site agonist of the NMDA receptors, D-cycloserine (DCS), exhibit an anti-immobility effect in the forced swim (FS) test, on adult mice. This effect, predicting antidepressive properties, is of the same order as those of imipramine (IMI). In constrast, DCS and IMI did not exhibited any significant anti-immobility effect on aged mice (12 months). IMI being active, in the depression of aged persons, it seems that the FS test has not any predictive value concerning the action of antidepressant drugs on aged persons. On the other hand Gabalid, a mixed (A, B) GABAergic agonist, AE37, a partial muscarinic agonist and N-linoleyl glycine, a mixed (A, B) glycinergic agonists, are active, in the FS test, on adult as well on aged mice. Mixed (A, B) glycinergic agonist, Gabalid or AE37 and, generally, partial muscarinic agonists, are active on the passive avoidance test (step-down) on mice, which predict nootropic effects. These results, considered in relation with recent data on the impact of FS or functional inhibition (GABAergic, glycinergic A, antimuscarinic) of glutamatergic neurons on the glycinergic modulation of the NMDA receptors, could suggest that the FS test on aged mice could possess a predictive value for nootropic rather than for antidepressant drugs.
Vamvakides
A
A
Laboratoire de Pharmacologie expérimentale, Faculté de Médecine d'Athènes, Grèce.
D000375:Aging / Q000523:psychology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003523:Cycloserine / Q000494:pharmacology*; D018755:GABA Agonists / Q000494:pharmacology; D007099:Imipramine / Q000494:pharmacology; D008297:Male; D051379:Mice; D009043:Motor Activity; D018721:Muscarinic Agonists / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology*; D013315:Stress, Psychological; D013550:Swimming; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000494:pharmacology
D018755:GABA Agonists; D018721:Muscarinic Agonists; D011619:Psychotropic Drugs; D005680:gamma-Aminobutyric Acid; C036611:gabalid; D003523:Cycloserine; D007099:Imipramine