Key role of acetyl-CoA in cytoplasm of nerve terminals in disturbances of acetylcholine metabolism in brain.
This paper review data indicating that the concentration of acetyl-CoA in cytoplasm of cholinergic terminals is an important factor which may determine the rate and size of quantal acetylcholine in different physiologic and pathologic conditions.
Szutowicz
A
A
Department of Clinical Biochemistry, School of Medicine, Gdanśk.
Tomaszewicz
M
M
Bielarczyk
H
H
D020155:3-Hydroxybutyric Acid / Q000494:pharmacology; D000105:Acetyl Coenzyme A / Q000502:physiology*; D000109:Acetylcholine / Q000378:metabolism*; D000535:Aluminum / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D001927:Brain Diseases / Q000378:metabolism*; D002799:Cholinergic Fibers / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D003920:Diabetes Mellitus / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D019289:Pyruvic Acid / Q000378:metabolism; D051381:Rats; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*
D004791:Enzyme Inhibitors; D000105:Acetyl Coenzyme A; D019289:Pyruvic Acid; D000535:Aluminum; D000109:Acetylcholine; D020155:3-Hydroxybutyric Acid