[Circadian variation of lymphocyte subsets in health subjects].
In our study cortisol and interleukin 2 (IL-2) levels were measured and lymphocyte sub-population analyses were performed on blood samples collected every four hours, for 24 hours from 10 healthy subjects aged 38-65 years. A clear circadian rhythm was validated for cortisol serum levels, for CD8, CD8 dim, CD16 and delta TcS1 with acrophase in the morning, and for CD2, CD4, CD/CD8 ratio, HLA-DR, CD20 and CD25 with acrophase at night. CD8 bright and TcR delta 1 presented higher levels in the morning without validation of the circadian rhythm. Changes of serum levels of IL-2 did not show circadian rhythmicity. The results show that specific lymphocyte subsets present different profiles of nyctohemeral changes and this may explain time related variations of immune responses.
Mazzoccoli
G
G
Dipartimento di Medicina Interna, IRCCS Casa Sollievo della Sofferenza, S. Giovanni Rotondo, Foggia.
Bianco
G
G
Correra
M
M
Carella
A M
AM
Balzanelli
M
M
Giuliani
A
A
Tarquini
R
R
D000328:Adult; D015703:Antigens, CD / Q000097:blood; D002940:Circadian Rhythm; D006684:HLA-DR Antigens / Q000097:blood; D006801:Humans; D007376:Interleukin-2 / Q000097:blood; D016131:Lymphocyte Subsets; D008214:Lymphocytes / Q000502:physiology*; D008875:Middle Aged; D012016:Reference Values
D015703:Antigens, CD; D006684:HLA-DR Antigens; D007376:Interleukin-2
Ritmo circadiano delle sottopopolazioni linfocitarie in soggetti sani.