title: Deciphering RNA recognition: aminoglycoside binding to the hammerhead ribozyme.
abstract: Aminoglycoside antibiotics inhibit protein biosynthesis and various ribozymes. Structural electrostatic complementarity can explain the inhibition mechanism of the hammerhead ribozyme: positively charged ammonium groups match the negatively charged metal-ion-binding pockets created by the RNA fold's electrostatic field.
authors.affiliation: Department of Chemistry and Biochemistry University of California San Diego La Jolla CA 92093-0358 USA. ytor@ucsd.edu.
authors.forename: Y
authors.initials: Y
authors.lastname: Tor
authors.forename: T
authors.initials: T
authors.lastname: Hermann
authors.forename: E
authors.initials: E
authors.lastname: Westhof
mesh_terms: D000617:Aminoglycosides / Q000378:metabolism*; D002240:Carbohydrate Sequence; D008969:Molecular Sequence Data; D012313:RNA / Q000737:chemistry / Q000378:metabolism*; D016337:RNA, Catalytic / Q000378:metabolism*
chemical_list: D000617:Aminoglycosides; D016337:RNA, Catalytic; D012313:RNA