Antiphospholipid syndrome and pregnancy loss.
Antiphospholipid antibodies (aPL) are associated with recurrent miscarriage. Pregnancies that survive the first trimester risk developing pre-eclampsia, intrauterine growth retardation and fetal distress during labour. Pregnancy loss is initially caused by defective embryonic implantation and later by thrombosis of the placental vasculature. In women with aPL, thromboprophylaxis during pregnancy improves the live birth rate.
Rai
R
R
Department of Obstetrics and Gynaecology, Hillingdon Hospital, Uxbridge.
Regan
L
L
D000026:Abortion, Habitual / Q000209:etiology* / Q000517:prevention & control; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000925:Anticoagulants / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000175:diagnosis; D001241:Aspirin / Q000627:therapeutic use; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D005260:Female; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000150:complications
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000925:Anticoagulants; D006493:Heparin; D001241:Aspirin