title: DNA repair: getting past a lesion - at a cost.
abstract: Bacteria survive many types of synthesis-blocking DNA lesion by inducing a number of proteins that enable their polymerases to synthesize past a lesion, albeit at the cost of an increased mutation rate. This process has now been convincingly achieved in vitro, opening the way to a fuller understanding of the mechanism.
authors.affiliation: MRC Cell Mutation Unit University of Sussex, Falmer, Brighton, East Sussex BN1 9RR, UK.
authors.forename: B A
authors.initials: BA
authors.lastname: Bridges
mesh_terms: D001419:Bacteria / Q000235:genetics / Q000378:metabolism; D001426:Bacterial Proteins / Q000378:metabolism; D004249:DNA Damage; D004258:DNA Polymerase III / Q000378:metabolism; D004260:DNA Repair / Q000235:genetics / Q000502:physiology*; D004269:DNA, Bacterial / Q000235:genetics / Q000378:metabolism; D004259:DNA-Directed DNA Polymerase; D029968:Escherichia coli Proteins; D020035:Holoenzymes / Q000378:metabolism; D009154:Mutation; D011938:Rec A Recombinases / Q000378:metabolism; D013014:SOS Response, Genetics / Q000235:genetics / Q000502:physiology
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial; D029968:Escherichia coli Proteins; D020035:Holoenzymes; C078202:UmuC protein, E coli; D011938:Rec A Recombinases; D004258:DNA Polymerase III; D004259:DNA-Directed DNA Polymerase; C055218:UmuD protein, E coli