WAY-100635 reverses 8-OH-DPAT-induced performance impairment in the radial maze.
1. The effects of the 5-HT1A receptor agonist, (8-OH-DPAT), alone and in combination with the selective 5-HT1A antagonist, WAY-100635, were assessed in Fischer-344 rats in an 8-arm radial maze. 2. At a dose of 1.0 mg/kg, 8-OH-DPAT significantly reduced both efficiency of performance (% correct arm entries) and response rate (arms/min) compared with the saline condition. 3. These effects were completely blocked by WAY-100635 which by itself had no effect on efficiency or response rate. 4. WAY-100635 inhibits 8-OH-DPAT-induced impairment in radial maze performance.
Helsley
S
S
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, USA.
Siegel
T L
TL
Fiorella
D
D
Rabin
R A
RA
Winter
J C
JC
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D008297:Male; D018782:Maze Learning / Q000187:drug effects* / Q000502:physiology; D010879:Piperazines / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D011985:Receptors, Serotonin / Q000502:physiology; D044263:Receptors, Serotonin, 5-HT1; D012702:Serotonin Antagonists / Q000494:pharmacology*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology
D010879:Piperazines; D011725:Pyridines; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; C090413:N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin