title: Sclerosing sweat-duct carcinoma (malignant syringoma) of the upper eyelid: a patient report with immunohistochemical and ultrastructural analysis.
abstract: Sclerosing sweat-duct carcinoma or malignant syringoma is a rare eyelid tumor. The authors report the first patient with sclerosing sweat-duct carcinoma involving the upper eyelid and present its immunohistochemical and ultrastructural features. The clinical features and the histopathologic and ultrastructural findings that distinguish this tumor from its benign counterparts are discussed. Sclerosing sweat-duct carcinomas are slow growing but locally invasive neoplasms that have a propensity to recur. Wide and deep surgical excision with frozen section evaluation of margins is recommended.
authors.affiliation: Department of Ophthalmology, McMaster University, Hamilton, Ontario, Canada.
authors.forename: B
authors.initials: B
authors.lastname: Esmaeli
authors.forename: J A
authors.initials: JA
authors.lastname: Ramsay
authors.forename: K A
authors.initials: KA
authors.lastname: Chorneyko
authors.forename: C L
authors.initials: CL
authors.lastname: Wright
authors.forename: J T
authors.initials: JT
authors.lastname: Harvey
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D002272:Carcinoembryonic Antigen / Q000032:analysis; D005142:Eyelid Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D005143:Eyelids / Q000601:surgery / Q000648:ultrastructure*; D006801:Humans; D007124:Immunoenzyme Techniques; D007633:Keratins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D018396:Mucin-1 / Q000096:biosynthesis; D013544:Sweat Gland Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D013545:Sweat Glands / Q000601:surgery / Q000648:ultrastructure*; D018252:Syringoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D018396:Mucin-1; D007633:Keratins