The dynamic structure of the germinal center.
Analysis of germinal centers (GCs) in chronically inflamed human tonsils has led to the dogma that GCs contain two compartments with separate functions: a dark zone where B cells proliferate and hypermutate; and a light zone where selection and differentiation occur. However, here Stephanie Camacho and colleagues discuss immunohistological analysis of splenic GCs arising de novo that reveal a more plastic structure.
Camacho
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Deutsches Rheuma ForschungsZentrum, Berlin, Germany. berek@drfz.de
Kosco-Vilbois
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Berek
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D000818:Animals; D000911:Antibodies, Monoclonal; D000944:Antigens, Differentiation, B-Lymphocyte / Q000032:analysis; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D002455:Cell Division; D002645:Chickens; D003713:Dendritic Cells / Q000276:immunology; D018858:Germinal Center / Q000276:immunology*; D007150:Immunohistochemistry; D051379:Mice; D008807:Mice, Inbred BALB C; D010081:Oxazolone / Q000276:immunology; D019887:Peanut Agglutinin / Q000276:immunology; D017455:Receptors, IgE / Q000032:analysis; D012709:Serum Albumin / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013997:Time Factors
D000911:Antibodies, Monoclonal; D000944:Antigens, Differentiation, B-Lymphocyte; D000945:Antigens, Differentiation, T-Lymphocyte; D019887:Peanut Agglutinin; D017455:Receptors, IgE; D012709:Serum Albumin; D010081:Oxazolone