Effect of cisapride on gastroduodenal reflux and gall bladder motility in patients with gallstones.
The aim of this work was to assess the effect of 10 mg of cisapride twice daily for 1 week on symptoms, gastroduodenal reflux and gall bladder emptying in patients undergoing cholecystectomy. Seventy-seven patients, 29 male and 48 female, underwent a randomized, double-blind, placebo-controlled trial with a 1-week treatment period between studies before cholecystectomy. Fifty-one of these patients were suitable for gall bladder emptying ejection fraction analysis. Gastroduodenal reflux and gall bladder emptying were assessed using Milk 99Tcm DIDA scans. Cisapride did not significantly alter gastroduodenal reflux but gall bladder motility was altered after cisapride treatment (p < 0.05).
Baxter
P S
PS
Department of Surgery, The Queen Elizabeth Hospital, Woodville, SA, Australia.
Maddern
G J
GJ
D000328:Adult; D000368:Aged; D002763:Cholecystectomy; D020117:Cisapride / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D004383:Duodenogastric Reflux / Q000188:drug therapy*; D005260:Female; D016473:Gallbladder Emptying / Q000187:drug effects*; D005765:Gastrointestinal Agents / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged
D005765:Gastrointestinal Agents; D020117:Cisapride