title: Lactic acid-mediated suppression of Helicobacter pylori by the oral administration of Lactobacillus salivarius as a probiotic in a gnotobiotic murine model.
abstract: OBJECTIVE
  We examined whether or not the lactobacilli administered to treat Helicobacter pylori (H. pylori) infection can suppress the colonization of H. pylori, and we also sought to elucidate the mechanism of such suppression.
  
  
  METHODS
  We used an in vitro culture system and an H. pylori-infected gnotobiotic murine model.
  
  
  RESULTS
  Among the lactobacillus species examined in vitro, Lactobacillus salivarius (L. salivarius) but not L. casei or L. acidophilus proved to be capable of producing a high amount of lactic acid and thus completely inhibiting the growth of H. pylori in a mixed culture. The validity of L. salivarius as a probiotic to suppress H. pylori and thus reduce the inflammatory response was again confirmed in vivo by using an H. pylori-infected gnotobiotic murine model.
  
  
  CONCLUSIONS
  Based on our findings, L. salivarius was found to be a potentially effective probiotic against H. pylori.
authors.affiliation: Department of Infectious Diseases, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Aiba
authors.forename: N
authors.initials: N
authors.lastname: Suzuki
authors.forename: A M
authors.initials: AM
authors.lastname: Kabir
authors.forename: A
authors.initials: A
authors.lastname: Takagi
authors.forename: Y
authors.initials: Y
authors.lastname: Koga
mesh_terms: D000818:Animals; D005856:Germ-Free Life; D016481:Helicobacter Infections / Q000382:microbiology*; D016480:Helicobacter pylori / Q000254:growth & development*; D019344:Lactic Acid / Q000096:biosynthesis / Q000494:pharmacology*; D007778:Lactobacillus / Q000378:metabolism / Q000502:physiology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D019936:Probiotics
chemical_list: D019344:Lactic Acid