In vitro activities of ketolide HMR 3647, macrolides, and clindamycin against Coryneform bacteria.
The in vitro activity of ketolide HMR 3647 against coryneform bacteria isolated from clinical samples was evaluated. Except against Corynebacterium jeikeium and C. urealyticum, HMR 3647 showed high activity against Corynebacterium spp., being more active than 14- and 16-membered macrolides, azithromycin, or clindamycin. HMR 3647 also had high in vitro activity against Brevibacterium spp. and Listeria monocytogenes.
Martínez-Martínez
L
L
Department of Microbiology, Hospital Universitario Virgen Macarena, Seville, Spain. lmartin@cica.es
Pascual
A
A
Suárez
A I
AI
Perea
E J
EJ
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001951:Brevibacterium / Q000187:drug effects; D002981:Clindamycin / Q000494:pharmacology*; D003352:Corynebacterium / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D048628:Ketolides; D008089:Listeria monocytogenes / Q000187:drug effects; D018942:Macrolides; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D048628:Ketolides; D018942:Macrolides; D002981:Clindamycin; C106791:telithromycin