[Autonomic nervous function of the patients with neurally mediated syncope].
Although diagnosis of neurally mediated syncope (NMS) using head-up tilt (HUT) test has been established, the exact mechanism of NMS has not yet been elucidated. We evaluated beta and alpha-adrenergic function in NMS patients by pharmacological autonomic function test. The alpha-adrenergic sensitivity of NMS patients was significantly lower than that of control subjects. The patients who need low dose isoproterenol for provocation of syncope showed higher beta-adrenergic sensitivity than patients who developed syncope without isoproterenol. Thus, pharmacological autonomic function test was useful for evaluation of NMS patients.
Saitoh
H
H
1st Department of Internal Medicine, Nippon Medical School, Tokyo.
Ono
T
T
Nomura
A
A
Iwasaki
Y
Y
Ohno
N
N
Matsumoto
S
S
Kobayashi
Y
Y
Atarashi
H
H
Katoh
T
T
Kishida
H
H
Hayakawa
H
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D001341:Autonomic Nervous System / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007545:Isoproterenol; D008297:Male; D008722:Methods; D008875:Middle Aged; D011187:Posture; D019462:Syncope, Vasovagal / Q000503:physiopathology*
D007545:Isoproterenol