Granulocyte colony-stimulating factor administered as a single intraperitoneal injection modifies the lethal dose95/30 in irradiated B6D2F1 mice.
Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic growth factor that stimulates the proliferation of progenitor myeloid cells. We have previously demonstrated that recombinant human G-CSF (rhG-CSF) significantly improves survival of lethally irradiated B6D2F1 mice when administered as a single intraperitoneal dose of 1 mg/kg 2 hours after a lethal dose (LD)95/30 irradiation. In our model, rhG-CSF is also able to modify the LD95/30 in irradiated animals and 1.1 has been found to be the dose modification factor (the ratio of LD95/30 for mice treated with rhG-CSF to that for control animals).
Sureda
A
A
Kádár
E
E
Valls
A
A
García-López
J
J
D000818:Animals; D001855:Bone Marrow Diseases / Q000188:drug therapy* / Q000209:etiology; D002470:Cell Survival / Q000187:drug effects; D004307:Dose-Response Relationship, Radiation; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007274:Injections, Intraperitoneal; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000188:drug therapy*; D011993:Recombinant Fusion Proteins / Q000627:therapeutic use
D011993:Recombinant Fusion Proteins; D016179:Granulocyte Colony-Stimulating Factor