title: [Use of SHU 508 A Levovist contrast media in the characterization of solid lesions of the breast].
abstract: BACKGROUND
  We investigated the effectiveness of Levovist (SHU508A, Schering AG, Berlin, Germany) in the characterization of breast lesions.
  
  
  METHODS
  June, 1996, to May, 1997, we studied 29 solid lesions in 29 patients (aged 17 to 83 years); our patients were 28 women and 1 man. The 29 solid lesions were 20 carcinomas (15 infiltrating ductal carcinomas, 4 ductal carcinomas in situ, 1 lobular carcinoma in situ), 6 fibroadenomas, 1 suspected postoperative recurrence and 2 apparently benign lesions. We used parameters suitable for the study of slow flows. A single bolus of contrast agent (300 mg/mL) was administered at 1-2 mL/s. Before Levovist injection, we studied the lesion signal intensity and the number of vascular poles. After contrast administration we re-evaluated both these parameters and studied the changes or presence of vessels undetected on the previous images. We also investigated the beginning and duration of enhancement and the presence of vessels inside and outside the lesions.
  
  
  RESULTS
  We observed no signal enhancement in 17% of cases, mild enhancement in 7% and strong enhancement in 76% of cases. We found 3 more vascular poles (17%) in 5 lesions and 4 more poles in 3 lesions (10%). Increased vascularization was seen inside the lesion in 17% of cases, inside and outside it in 41% and only outside in 35% of cases. Carcinomas showed a rapid and long-lasting enhancement, while fibroadenomas showed a later and weaker enhancement.
  
  
  CONCLUSIONS
  Levovist can be useful in the differential diagnosis of benign from malignant lesions, of recurrences from postoperative fibrosis, as well as in the staging and follow-up of the patients treated with neoadjuvant chemotherapy.
authors.affiliation: Istituto di Radiologia, Università degli Studi Tor Vergata, Ospedale S. Eugenio, ASL, Roma.
authors.forename: M
authors.initials: M
authors.lastname: Guazzaroni
authors.forename: E
authors.initials: E
authors.lastname: Cossu
authors.forename: V
authors.initials: V
authors.lastname: Danese
authors.forename: M
authors.initials: M
authors.lastname: Montanaro
authors.forename: G
authors.initials: G
authors.lastname: Simonetti
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D018567:Breast Neoplasms, Male / Q000000981:diagnostic imaging; D003287:Contrast Media; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011134:Polysaccharides; D014463:Ultrasonography
chemical_list: D003287:Contrast Media; D011134:Polysaccharides; C059891:SHU 508
vernacular_title: Impiego del mezzo di contrasto Levovist SHU 508 A nella caratterizzazione delle lesioni solide della mammella.