Striatal transplants prevent AF64A-induced retention deficits.
The relevance of the cholinergic system in mnemonic processes has been repeatedly demonstrated. In addition to the cholinergic systems that project to the telencephalon, there are subcortical nuclei with intrinsic cholinergic cells which appear to be involved in memory consolidation; among these is the striatum. Intrastriatal administration of anticholinergic drugs, as well as excitotoxic and electrolytic lesions have been shown to disrupt the acquisition and retention of instrumentally conditioned behaviors. In the present study male Wistar rats were used to confirm the reported detrimental effects of striatal lesions produced by the cholinotoxin AF64A on long-term retention (LTR) of inhibitory avoidance and spontaneous locomotor activity, to determine its effects on short-term retention (STR) and to investigate whether intrastriatal homotopic transplants can reverse the AF64A-induced behavioral deficits. AF64A-striatal lesions did not interfere with STR but disrupted LTR of the inhibitory avoidance task, and striatal transplants prevented this deficit. Spontaneous locomotor activity increased after the lesion but promptly returned to baseline levels. These results support previous findings showing striatal involvement in long-term but not short-term retention and indicate that homotopic transplants induce behavioral recovery of a learning task in striatal lesioned rats.
Giordano
M
M
Centro de Neurobiología, Campus UNAM-UAQ, México, D. F., México. giordano@servidor.unam.mx
Salado-Castillo
R
R
Sánchez-Alvarez
M
M
Prado-Alcalá
R A
RA
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001388:Aziridines / Q000633:toxicity*; D016380:Brain Tissue Transplantation; D002794:Choline / Q000031:analogs & derivatives* / Q000633:toxicity; D016332:Fetal Tissue Transplantation; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced* / Q000503:physiopathology / Q000517:prevention & control* / Q000601:surgery; D008570:Memory, Short-Term / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D017072:Neostriatum / Q000187:drug effects* / Q000502:physiology / Q000601:surgery / Q000637:transplantation*; D009466:Neuromuscular Blocking Agents / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D014184:Transplantation, Homologous
D001388:Aziridines; D009466:Neuromuscular Blocking Agents; C044894:ethylcholine aziridinium; D000110:Acetylcholinesterase; D002794:Choline