Immunotoxic effects of organotin compounds in Tapes philippinarum.
One of the most harmful groups of coastal pollutants is the organotin compounds (OTCs) which have severe effects on both aquatic organisms and mammals including humans. The immunotoxic effects of OTCs were studied in the cultivated clam Tapes philippinarum by determining the immunosuppressant role on in vitro yeast phagocytosis at low doses (0.01, 0.05, 0.1 microM). The phagocytic index was significantly reduced in an irreversible non-lethal manner depending on concentration and lipophilic affinity. The order of inhibition was TBT > or = DBT > MBT for butyltins and TPTC > TPTA > or = TPTH for triphenyltins.
Cima
F
F
Dept. of Biology, University of Padova, Venezia, Italy.
Marin
M G
MG
Matozzo
V
V
Da Ros
L
L
Ballarin
L
L
D000818:Animals; D049872:Bivalvia / Q000187:drug effects* / Q000276:immunology; D004784:Environmental Monitoring / Q000379:methods; D007166:Immunosuppressive Agents / Q000633:toxicity*; D007558:Italy; D009947:Organotin Compounds / Q000633:toxicity*; D010587:Phagocytosis / Q000187:drug effects; D013329:Structure-Activity Relationship
D007166:Immunosuppressive Agents; D009947:Organotin Compounds