title: Assessing insulin sensitivity in the cat: evaluation of the hyperinsulinemic euglycemic clamp and the minimal model analysis.
abstract: Current methods of assessing glucose tolerance in the cat are inadequate for quantifying insulin sensitivity. The hyperinsulinemic euglycemic clamp (EGC) and the minimal model analysis (MMA) of the frequently sampled intravenous glucose tolerance test (FSIGT) have been used in other species to assess the effects of insulin on glucose homeostasis. Each of these procedures was performed on healthy cats, two weeks apart, to generate indices of insulin sensitivity - M/I (amount of glucose metabolised per unit of plasma insulin concentration) from the EGC and S(I) (insulin sensitivity) from the MMA. Close and significant correlation between M/I and S(I) in individual cats was found (r=0.91, P=0.032). Use of these research methods may further our understanding of feline diabetes mellitus and other endocrinopathies.
authors.affiliation: Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706, USA.
authors.forename: D J
authors.initials: DJ
authors.lastname: Petrus
authors.forename: M W
authors.initials: MW
authors.lastname: Jackson
authors.forename: J W
authors.initials: JW
authors.lastname: Kemnitz
authors.forename: D T
authors.initials: DT
authors.lastname: Finegood
authors.forename: D
authors.initials: D
authors.lastname: Panciera
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D002415:Cats; D005947:Glucose / Q000378:metabolism*; D015309:Glucose Clamp Technique / Q000662:veterinary*; D005951:Glucose Tolerance Test / Q000662:veterinary; D006706:Homeostasis; D006946:Hyperinsulinism; D007262:Infusions, Intravenous; D007328:Insulin / Q000008:administration & dosage / Q000494:pharmacology*; D015233:Models, Statistical
chemical_list: D001786:Blood Glucose; D007328:Insulin; D005947:Glucose