[Genetics of Alzheimer's disease].
This review reports epidemiological data and biological mechanisms about the Apolipoprotein E gene allele epsilon 4 that is a major risk factor for Alzheimer's disease (AD). The second part describes the three genes, amyloid precusor protein (APP), presenilin 1 (PS1) and presenilin 2 (PS2) genes, which when mutated cause early-onset autosomal dominant AD. Mutations on each of these genes have as a common consequence elevated levels of A beta (42,3).
Hannequin
D
D
Fédération de Neurologie, CHU, Rouen.
Campion
D
D
Dumanchin
C
C
Martinez
M
M
Agid
Y
Y
Clerget-Darpoux
F
F
Frebourg
T
T
Brice
A
A
D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism / Q000523:psychology; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000378:metabolism; D005819:Genetic Markers; D006801:Humans; D012307:Risk Factors
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D005819:Genetic Markers
Génétique de la maladie d'Alzheimer.