Effect of aflatoxicosis on the kinetic behaviour of ceftiofur in chickens.
The kinetic behaviour of ceftiofur sodium was studied in aflatoxin treated chickens for 30 days and in non-treated chickens, following oral, intramuscular and intravenous administrations of 10 mg kg(-1) bodyweight of ceftiofur. Aflatoxicosis resulted in a more significant decrease in ceftiofur serum concentration in the treated than in non-treated chickens following oral and intravenous administrations. The kinetic behaviour showed that following intravenous injection the elimination half life time t0.5 (el) was significantly shorter in the treated chickens (1.75+/-0.03 hours) than in non-treated chickens (4.23+/-0.05 hours). Following oral administration, the kinetic behaviour revealed a longer absorption half-life [t0.5 (ab), 62.74+/-1.59 minutes] in the treated chickens than in non-treated (50.46+/-5.07 minutes), with lower Cmax 23.25+/-0.42 microg ml(-1) at long tmax (3.05+/-0.07 hour) in treated chickens than in non-treated (Cmax 27.83+/-1.28 at tmax 2.39+/-0.07 hours).
Amer
A M
AM
Pharmacology Department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
Fahim
E M
EM
Ibrahim
R K
RK
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D001835:Body Weight; D002511:Cephalosporins / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D002645:Chickens; D006207:Half-Life; D007275:Injections, Intravenous; D015651:Mycotoxicosis / Q000097:blood / Q000503:physiopathology / Q000662:veterinary*; D011041:Poisoning / Q000097:blood / Q000503:physiopathology / Q000662:veterinary*; D014018:Tissue Distribution; D000096702:Aflatoxin Poisoning
D001798:Blood Proteins; D002511:Cephalosporins; C053503:ceftiofur