[Cytoprotective effect of ethyl esters of n-3 polyunsaturated fatty acids].
Protective properties of n-3 and n-6 polyunsaturated, monosaturated and saturated fatty acids (respectively, n-3 PUFA, n-6 PUFA, MUFA and SFA) against ethanol induced hemorrhagic gastric mucosal lesions were compared. Female Wistar rats (90-100 g) were fed to four weeks semisyntethic diets containing 9% butter (SFA-diet), 6% butter and 3% olive oil (MUFA-diet), 6% butter and 3% sunflower oil (n-6 PUFA-diet) or 6% butter and 3% concentrate of n-3 PUFA ethyl esters (n-3 PUFA-diet). One group of rats received a non-lipid diet. Under all types of lipid containing diets, development of ethanol-induced hemorrhagic gastric mucosal lesions was reduced in compared with non-lipid diet. Cytoprotective effect of n-3 PUFA-E was greater than MUFA and SFA, but smaller than n-6 PUFA.
Tiupeleev
P A
PA
Kirillov
O I
OI
Kas'ianov
S P
SP
Latyshev
N A
NA
D000818:Animals; D019610:Cytoprotection / Q000187:drug effects*; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage / Q000494:pharmacology*; D004952:Esters; D000431:Ethanol; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000494:pharmacology; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D006470:Hemorrhage / Q000139:chemically induced / Q000188:drug therapy; D000069463:Olive Oil; D010938:Plant Oils / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D000074242:Sunflower Oil
D004042:Dietary Fats, Unsaturated; D004952:Esters; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated; D000069463:Olive Oil; D010938:Plant Oils; D000074242:Sunflower Oil; D000431:Ethanol
Tsitoprotektivnaia aktivnost' kontsentrata étilovykh éfirov n-3 polienovykh zhirnykh kislot.