title: Reading DNA differently.
abstract: Product inhibition has provided the limiting barrier to efficient template-directed ligation and polymerization reactions. Here we review the attempts to circumvent this limitation and outline a translation strategy that does overcome the barrier and allows the information encoded in DNA to be read and amplified into backbone-modified oligonucleotides.
authors.affiliation: G. D. Searle Chemistry Laboratory, University of Chicago, IL 60637, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Gat
authors.forename: D G
authors.initials: DG
authors.lastname: Lynn
mesh_terms: D002384:Catalysis; D004247:DNA / Q000235:genetics*; D008958:Models, Molecular; D014176:Protein Biosynthesis; D013698:Templates, Genetic
chemical_list: D004247:DNA