title: Location and function of linker histones.
abstract: The linker histones, H1 and its variant forms, have been implicated in the formation of higher orders of chromatin structure and gene repression. Three recent manuscripts have reexamined the location of H1 within the nucleosome particle and its function in the regulation of transcription.
authors.forename: M
authors.initials: M
authors.lastname: Vignali
authors.forename: J L
authors.initials: JL
authors.lastname: Workman
mesh_terms: D000818:Animals; D002843:Chromatin / Q000648:ultrastructure; D018360:Crystallography, X-Ray; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D006657:Histones / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008957:Models, Genetic; D009707:Nucleosomes / Q000648:ultrastructure*; D011401:Promoter Regions, Genetic; D011487:Protein Conformation; D012341:RNA, Ribosomal, 5S / Q000737:chemistry / Q000235:genetics; D035582:Transcription Factor TFIIIA; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D002843:Chromatin; D004268:DNA-Binding Proteins; D006657:Histones; D009707:Nucleosomes; D012341:RNA, Ribosomal, 5S; D035582:Transcription Factor TFIIIA; D014157:Transcription Factors