A novel antiprotozoal aminosteroid from Saracha punctata.
A new aminosteroid, 3beta-amino-22,26-epiminocholest-5-ene named sarachine (1), and two known flavonoids, eriodictyol (2) and 7-O-beta-D-glucopyranosyl-eriodictyol (3), were isolated from the leaves of Saracha punctata. The alkaloid was found to inhibit the growth of Leishmania braziliensis promastigotes (100% at 25 microM) and of Trypanosoma cruzi epimastigotes in culture (50% at 25 microM) and showed a strong in vitro antiplasmodial activity with an IC50 of 25 nM.
Moretti
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Institut Français de Recherche Scientifique pour le Développement en Coopération (ORSTOM), Unité de Recherche No. 45, 209-213 rue La Fayette 75480 Paris Cedex 10, France.
Sauvain
M
M
Lavaud
C
C
Massiot
G
G
Bravo
J
J
Muñoz
V
V
D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002782:Cholestenes / Q000302:isolation & purification / Q000494:pharmacology*; D007892:Leishmania braziliensis / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry*; D010962:Plasmodium berghei / Q000187:drug effects; D014344:Trypanocidal Agents / Q000302:isolation & purification / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects
D000962:Antimalarials; D000981:Antiprotozoal Agents; D002782:Cholestenes; D014344:Trypanocidal Agents; C117179:serachine