Plasma and urinary endothelin-1 titers and plasma von Willebrand activity in Pseudoxanthoma elasticum.
We found high endothelin-1 and von Willebrand factor plasma titers not only in two individuals (daughter and father) affected with Pseudoxanthoma elasticum but also in a young unaffected relative. These findings raise the possibility that these molecules could be the first biochemical fingerprints of this, still not clinically evident, rare inherited disorder of elastic tissue.
Amadeo
A
A
Bertulezzi
G
G
Civelli
L
L
Porta
C
C
Moroni
M
M
D000328:Adult; D015415:Biomarkers; D019332:Endothelin-1 / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D011561:Pseudoxanthoma Elasticum / Q000097:blood* / Q000235:genetics / Q000652:urine*; D014841:von Willebrand Factor / Q000032:analysis*
D015415:Biomarkers; D019332:Endothelin-1; D014841:von Willebrand Factor