title: Endotoxin temporarily impairs canine jejunal absorption of water, electrolytes, and glucose.
abstract: Enteral feeding during and after episodes of sepsis may be beneficial. The aim of our study was to determine the effects of a single sublethal dose of endotoxin on canine jejunal absorption. Following a 240 kcal liquid meal, absorption studies were performed in eight dogs with 75 cm jejunal Thiry-Vella fistulas. These fistulas were perfused with an isotonic solution containing polyethylene glycol to calculate absorption. Each dog was then given a single dose of Escherichia coli lipopolysaccharide, 200 microg/kg intravenously, and the studies were repeated for the next 3 days. Following endotoxin bolus infusion, net absorption of water, electrolytes, and glucose was decreased for 2 days and returned to baseline values on postendotoxin day 3. A single sublethal dose of endotoxin temporarily impairs canine jejunal absorption. Although enteral feeding may be advantageous, jejunal absorption may be temporarily impaired following an episode of endotoxemia.
authors.affiliation: Department of Surgery, University of Iowa College of Medicine and Veterans Affairs Medical Center, Iowa City, Iowa, USA.
authors.forename: J J
authors.initials: JJ
authors.lastname: Cullen
authors.forename: L L
authors.initials: LL
authors.lastname: Hemann
authors.forename: K S
authors.initials: KS
authors.lastname: Ephgrave
authors.forename: M M
authors.initials: MM
authors.lastname: Hinkhouse
mesh_terms: D000818:Animals; D004285:Dogs; D004573:Electrolytes / Q000378:metabolism*; D019446:Endotoxemia / Q000378:metabolism; D004731:Endotoxins / Q000494:pharmacology*; D004926:Escherichia coli; D005947:Glucose / Q000378:metabolism*; D007408:Intestinal Absorption / Q000187:drug effects*; D007583:Jejunum / Q000378:metabolism*; D019518:Postprandial Period; D014867:Water / Q000378:metabolism*
chemical_list: D004573:Electrolytes; D004731:Endotoxins; D014867:Water; D005947:Glucose