title: Prenatal diagnosis of congenital toxoplasmosis transmitted by an immunocompetent woman infected before conception. Reims Toxoplasmosis Group.
abstract: We report a rare case of congenital toxoplasmosis transmitted by an immunocompetent woman infected before conception. Active toxoplasmosis was suspected due to persistent lymphadenitis with specific IgM, IgA, IgE antibodies. Prenatal diagnosis based on amniocentesis and fetal blood sampling at 24 weeks' amenorrhoea was positive on amniotic fluid, and fetal infection was confirmed after termination. In our opinion such cases need the same monitoring as when seroconversion occurs during the first trimester. A pregnancy-free interval of six to nine months is recommended after proven patent toxoplasmosis seroconversion.
authors.affiliation: Laboratory of Parasitology-Mycology, Team 4 (Inserm U.314), Hôpital Maison Blanche, Reims, France.
authors.forename: I
authors.initials: I
authors.lastname: Villena
authors.forename: C
authors.initials: C
authors.lastname: Chemla
authors.forename: C
authors.initials: C
authors.lastname: Quereux
authors.forename: D
authors.initials: D
authors.lastname: Dupouy
authors.forename: B
authors.initials: B
authors.lastname: Leroux
authors.forename: F
authors.initials: F
authors.lastname: Foudrinier
authors.forename: J M
authors.initials: JM
authors.lastname: Pinon
mesh_terms: D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood; D016054:DNA, Protozoan / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000469:parasitology; D005315:Fetal Diseases / Q000175:diagnosis* / Q000469:parasitology; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007073:Immunoglobulin E / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014122:Toxoplasma / Q000235:genetics / Q000276:immunology; D014125:Toxoplasmosis, Congenital / Q000175:diagnosis* / Q000469:parasitology
chemical_list: D000913:Antibodies, Protozoan; D016054:DNA, Protozoan; D007070:Immunoglobulin A; D007075:Immunoglobulin M; D007073:Immunoglobulin E