Correlation of cecal microflora of HLA-B27 transgenic rats with inflammatory bowel disease.
Transgenic rats with a high level of expression of the human major histocompatibility complex class I molecule HLA-B27 develop chronic inflammatory bowel disease (IBD) and arthritis. Assessment of the cecal microflora showed a rise in numbers of Escherichia coli and Enterococcus spp., corresponding to the presence and severity of IBD in these rats.
Onderdonk
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Channing Laboratory, Departments of Medicine and Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. ABONDERDON2BICS.BWH.HARVARD.EDU
Richardson
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JA
Hammer
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RE
Taurog
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D000818:Animals; D030801:Animals, Genetically Modified; D002432:Cecum / Q000382:microbiology*; D016983:Enterococcus / Q000302:isolation & purification; D004926:Escherichia coli / Q000302:isolation & purification; D005260:Female; D015796:HLA-B27 Antigen / Q000096:biosynthesis* / Q000235:genetics; D015212:Inflammatory Bowel Diseases / Q000382:microbiology*; D008297:Male; D051381:Rats
D015796:HLA-B27 Antigen