Effects of somatostatin on proximal gastric motor function and visceral perception.
BACKGROUND
Somatostatin affects gastrointestinal motility and secretion and visceral sensation, but little is known about its effects on the proximal stomach.


OBJECTIVE
To evaluate the effects of somatostatin on proximal gastric motor function and perception of symptoms.


METHODS
Six healthy subjects participated in two experiments performed in random order during continuous intravenous infusion of saline or somatostatin (250 microg/h). Proximal gastric motor function was evaluated using a barostat. We performed pressure and volume distensions and a barostat procedure (minimal distending pressure + 2 mmHg). Symptoms were evaluated at regular intervals using visual analogue scales (VAS).


RESULTS
Neither minimal distending pressure nor gastric fundal tone were significantly different between somatostatin and saline. Pressure-volume curves during distensions were not influenced by somatostatin. However, phasic volume waves were significantly (P < 0.001) reduced by somatostatin, and somatostatin significantly (P < 0.05) reduced symptom perception of fullness and abdominal pressure during stepwise distensions.
Mearadji
B
B
Department of Gastroenterology-Hepatology, Leiden University Medical Center, The Netherlands.
Straathof
J W
JW
Biemond
I
I
Lamers
C B
CB
Masclee
A A
AA
D000328:Adult; D000704:Analysis of Variance; D002404:Catheterization; D004311:Double-Blind Method; D005260:Female; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D011863:Radioimmunoassay; D012677:Sensation / Q000187:drug effects*; D013004:Somatostatin / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D013270:Stomach / Q000187:drug effects* / Q000502:physiology
D005765:Gastrointestinal Agents; D013004:Somatostatin