T-cell signal transduction and the role of protein kinase C.
The T lymphocyte has a vital part to play in maintaining the host response to bacterial and viral infection and also appears to play a key pathological role in autoimmune diseases such as rheumatoid arthritis. In this review, we summarize the signalling pathways which trigger antigen-driven T-cell proliferation and examine the evidence which suggests that protein kinase C (PKC) is fundamental to this process. Finally, we discuss the therapeutic potential that PKC inhibitors may have in the treatment of autoimmune disease.
Wilkinson
S E
SE
Department of Biology, Roche Discovery Welwyn, Welwyn Garden City, Herts, UK. sandra.orchard@roche.com
Nixon
J S
JS
D000818:Animals; D006801:Humans; D011493:Protein Kinase C / Q000502:physiology*; D015398:Signal Transduction / Q000276:immunology*; D013601:T-Lymphocytes / Q000502:physiology*
D011493:Protein Kinase C