Colonization with Pseudomonas aeruginosa in patients developing ventilator-associated pneumonia.
To determine routes of colonization and genotypic variation of Pseudomonas aeruginosa leading to ventilator-associated pneumonia, colonization of the rectum, stomach, oropharynx, and trachea was studied chronologically in 10 patients. Ninety-one isolates of P aeruginosa were genotyped; seven different genotypes were identified. Patients developing ventilator-associated pneumonia caused by P aeruginosa were colonized at multiple body sites and may be colonized with multiple genotypes. The upper respiratory tract is the predominant initial site of colonization with P aeruginosa.
Bergmans
D C
DC
Department of Internal Medicine, University Hospital Maastricht, The Netherlands.
Bonten
M J
MJ
Stobberingh
E E
EE
van Tiel
F H
FH
van der Geest
S
S
de Leeuw
P W
PW
Gaillard
C A
CA
D006801:Humans; D009960:Oropharynx / Q000382:microbiology; D018410:Pneumonia, Bacterial / Q000209:etiology* / Q000382:microbiology / Q000517:prevention & control; D011446:Prospective Studies; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification*; D012007:Rectum / Q000382:microbiology; D012121:Respiration, Artificial / Q000009:adverse effects*; D013270:Stomach / Q000382:microbiology; D014132:Trachea / Q000382:microbiology