[HLA-DR:DQ genotypes and insulin-dependent diabetes in Senegal].
At the opposite of HLA-DR, HLA-DQ was not well documented in homogeneous negroïd populations. So, 93 IDDM and 115 control patients, all black senegalese people, were studied. The results showed three HLA-DQ IDDM-related susceptibility genotypes and also a high risk conferred by HLA-DR4/DR9 usually described in Mongoloïd people. Furthermore, DR:DQ associations allowed the identification of three IDDM predisposition genotypes, each of them with a characteristic mean age for disease diagnosis.
Cisse
A
A
Laboratoire de Physique Pharmaceutique-Faculté de Médecine et de Pharmacie, Université Cheikh Anta DIOP, Dakar, Sénegal.
Chauffert
M
M
Julier
C
C
Chevenne
D
D
Michel
S
S
Trivin
F
F
Diop
S N
SN
Sidibe
E H
EH
Sow
A M
AM
D000328:Adult; D044383:Black People / Q000235:genetics*; D016022:Case-Control Studies; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005260:Female; D005820:Genetic Testing; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D012675:Senegal
D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens
Génotypes HLA-DR:DQ et diabète insulino-dépendant en milieu sénégalais.