title: Gastroesophageal reflux in infants with hydrocephalus before and after ventriculo-peritoneal shunt operation.
abstract: Gastroesophageal reflux (GER) is common in neurologically impaired children, especially those with central nervous system disorders. The cause of GER in these children has not yet been defined, but in animal studies, acute elevation of intracranial pressure (ICP) has been shown to result in a decrease in lower esophageal sphincter pressure. Ten infants with hydrocephalus underwent esophageal pH monitoring prior to and after a ventriculoperitoneal (V-P) shunt operation. A significant degree of reflux was present in 5 patients with hydrocephalus prior to shunt operation and reverted to normal in 2. In the other 3 infants, the degree of reflux decreased as evidenced by fewer abnormal parameters and lower scoring in each of the parameters measured. Our study supports the contention that increased ICP in infants is indeed associated with GER. As 4 of the 5 infants with significant reflux suffered from an Arnold-Chiari malformation, a causal relation between increased ICP due to defects involving the fourth ventricle floor and GER is suggested.
authors.affiliation: Department of Pediatrics, Hadassah University Hospital, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
authors.forename: E
authors.initials: E
authors.lastname: Shteyer
authors.forename: E
authors.initials: E
authors.lastname: Rothman
authors.forename: S
authors.initials: S
authors.lastname: Constantini
authors.forename: E
authors.initials: E
authors.lastname: Granot
mesh_terms: D000208:Acute Disease; D000818:Animals; D005260:Female; D005764:Gastroesophageal Reflux / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D006849:Hydrocephalus / Q000150:complications* / Q000503:physiopathology / Q000601:surgery*; D006863:Hydrogen-Ion Concentration; D007223:Infant; D007231:Infant, Newborn; D019586:Intracranial Hypertension; D008297:Male; D017287:Ventriculoperitoneal Shunt