title: Effect of intracameral and intravitreal injection of calcitonin gene-related peptide on the intraocular pressure and outflow facility of aqueous humor in the rabbit.
abstract: After intracameral injection calcitonin gene-related peptide has been demonstrated to break the blood aqueous barrier and increase intraocular pressure in rabbits. However in cats, calcitonin gene-related peptide decreases intraocular pressure by increasing the outflow facility of aqueous humor. In the present study, the effect of intracameral injection of calcitonin gene-related peptide on the outflow facility in rabbits has been investigated and the intraocular pressure and outflow facility were measured following intravitreal administration of calcitonin gene-related peptide. The results demonstrate that in spite of the apparent pseudofacility component caused by a breakdown of the blood aqueous barrier also the true trabecular outflow is probably increased in the rabbit eye after intracameral injection of calcitonin gene-related peptide. The intravitreal administration of calcitonin gene-related peptide leaves the blood aqueous barrier intact and causes an increase in the outflow facility of aqueous humor with a concomitant long-lasting decrease in intraocular pressure.
authors.affiliation: Santen Oy, Tampere, Finland.
authors.forename: O
authors.initials: O
authors.lastname: Oksala
authors.forename: P
authors.initials: P
authors.lastname: Heino
authors.forename: H
authors.initials: H
authors.lastname: Uusitalo
authors.forename: A
authors.initials: A
authors.lastname: Palkama
mesh_terms: D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D018916:Blood-Aqueous Barrier / Q000187:drug effects; D015740:Calcitonin Gene-Related Peptide / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005136:Eye Proteins / Q000378:metabolism; D007267:Injections; D007429:Intraocular Pressure / Q000187:drug effects*; D011817:Rabbits; D014822:Vitreous Body
chemical_list: D005136:Eye Proteins; D015740:Calcitonin Gene-Related Peptide