DNA repair of adriamycin induced damage in mouse and human cells differing in catalase activity.
Catalase is known to counteract cytotoxic effect of adriamycin, used as an anti-neoplastic drug. In cells with low catalase activity no repair of adriamycin induced lesions was observed up to 48 h post treatment. In cells with high catalase activity after 48 h the repair was either complete or partial depending on the human or mouse cell type used.
Gruber
B M
BM
Department of Vitamin Drugs, Drug Institute, Warsaw, Poland.
Anuszewska
E L
EL
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D002374:Catalase / Q000378:metabolism*; D002478:Cells, Cultured; D004249:DNA Damage / Q000187:drug effects*; D004260:DNA Repair; D004317:Doxorubicin / Q000633:toxicity*; D004789:Enzyme Activation; D005347:Fibroblasts; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C
D000970:Antineoplastic Agents; D004317:Doxorubicin; D002374:Catalase