Targeted diagnosis of bladder and ureteral carcinoma using radiolabelled BDI-1.
The aim of this study is to investigate the possibility of radioimmunoimaging (RII) by radiolabelled anti-bladder carcinoma monoclonal antibody BDI-1 applied to diagnosis of bladder cancer and ureteral cancer. BDI-1 was labelled with 131I and 99mTc. The immunoreactivity, pharmacokinetics and biodistribution in mice were studied. RII was performed in 46 patients. The results showed that 131I, 99mTc-BDI-1 have satisfactory immunoreactivity and excellent tumor-locating properties. The blood clearance half-life T1/2alpha and T1/2beta were 35 h in the first phase and 151 h in the second phase, respectively. Thirty-nine patients were studied by an intravesical administration method; the sensitivity was 90.5%. Seven patients were studied by an intravenous administration method. The RII results of three cases with primary or recurrent bladder cancer and three cases with ureteral cancer were confirmed histologically. RII was negative in one patient with suspected lung metastasis that was shown on radiography. The investigation revealed that RII can be used as an auxiliary method for the detection of bladder cancer and may be valuable for the diagnosis of ureteral cancer.
Zhang
C L
CL
Department of Nuclear Medicine, The First Hospital of Beijing Medical University, P.R. of China.
Yu
L Z
LZ
Gu
F L
FL
Buka
S D
SD
Zu
S L
SL
Xie
S S
SS
Pan
Z Y
ZY
D000368:Aged; D000818:Animals; D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging* / Q000276:immunology; D002295:Carcinoma, Transitional Cell / Q000000981:diagnostic imaging* / Q000276:immunology; D003429:Cross Reactions; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007457:Iodine Radioisotopes; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000276:immunology; D009368:Neoplasm Transplantation; D011877:Radionuclide Imaging; D013667:Technetium; D014516:Ureteral Neoplasms / Q000000981:diagnostic imaging* / Q000276:immunology; D001749:Urinary Bladder Neoplasms / Q000000981:diagnostic imaging* / Q000276:immunology
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D007457:Iodine Radioisotopes; D009363:Neoplasm Proteins; D013667:Technetium