[Changes in blood pressure 24 hour monitoring data and quality of life in patients with systolic hypertension treated with arifon].
OBJECTIVE
The study of quality of life and 24-h monitoring blood pressure data in elderly patients with isolated systolic hypertension (SH) on arifon monotherapy.


METHODS
22 patients over 65 (mean age 69.8 +/- 1.3 years) suffering from SH entered the open trial. 24-h monitoring of blood pressure was performed at least 2 weeks after discontinuation of the previous antihypertensive treatment and after 4 weeks of arifon monotherapy (2.5 mg once a day). Quality of life was evaluated according to the standard SIP questionnaire.


RESULTS
Arifon 4-week treatment resulted in a significant fall of systolic pressure for 24 hours, day and night (by 16.2, 13.7 and 17.4%, respectively; p < 0.001). Variability of blood pressure did not change much. 24-h index for systolic and diastolic blood pressure increased 2-fold and by 46%, respectively. Moreover, the rate of the systolic pressure growth in the morning hours decreased by 36.7% (p < 0.05). Psychosomatic status by SIP questionnaire changed for the best.


CONCLUSIONS
Arifon is an effective treatment of SH and improves quality of life.
Kobalova
Zh D
ZhD
Kotovskaia
Iu V
IuV
Shkol'nikova
E E
EE
D000368:Aged; D001794:Blood Pressure / Q000187:drug effects*; D018660:Blood Pressure Monitoring, Ambulatory; D004232:Diuretics / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D007190:Indapamide / Q000627:therapeutic use*; D008297:Male; D011788:Quality of Life; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
D004232:Diuretics; D007190:Indapamide
Dinamika pokazateleĭ sutochnogo monitorirovaniia arterial'nogo davlenia i kachestva zhizni u bol'nykh sistolicheskoĭ gipertonieĭ pri monoterapii arifonom.