title: [Vasoactive factors in patients with a severe combined trauma].
abstract: 46 patients with craniocerebral trauma combined with chest, abdominal, locomotor injuries were hospitalized to the critical care unit. At admission, blood pressure was low, blood loss reached 28% of circulating blood volume. Serum levels of hydrocortisone, nitrite, the activity of angiotensin-converting enzyme (ACE) were measured at admission, on admission hour 4, 24, day 3 and 7. Vasopressor to vasodepressor ratio (hydrocortisone x ACE/nitrite) was also estimated. It was found that severe combined trauma induces an intensive and long-term rise of blood hydrocortisone (a 3-fold rise at admission). ACE activity was low at all the measurements, nitrite levels were reduced only on day 1 and went up to normal on posttrauma day 3-7. The ratio hydrocortisone x ACE/nitrite was significantly elevated in all tests. It is concluded that in severe combined trauma low blood pressure was unrelated to nitric oxide.
authors.forename: P P
authors.initials: PP
authors.lastname: Golikov
authors.forename: V I
authors.initials: VI
authors.lastname: Kartavenko
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Nikolaeva
authors.forename: A A
authors.initials: AA
authors.lastname: Andreev
authors.forename: B V
authors.initials: BV
authors.lastname: Davydov
authors.forename: I A
authors.initials: IA
authors.lastname: Gavrilenko
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008875:Middle Aged; D009104:Multiple Trauma / Q000097:blood*; D009573:Nitrites / Q000097:blood; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D014666:Vasomotor System / Q000502:physiology*
chemical_list: D009573:Nitrites; D007703:Peptidyl-Dipeptidase A; D006854:Hydrocortisone
vernacular_title: Sostoianie vazoaktivnykh faktorov u bol'nykh s tiazeloĭ sochetannoĭ travmoĭ.