Lymphocyte and cytokine responses of young cattle during primary infection with Fasciola hepatica.
An experiment was designed to characterise the early immune responses of cattle given a trickle infection of the trematode Fasciola hepatica. Lymphocyte responses and IFNgamma production following stimulation with Fasciola antigens were measured. Animals were sequentially slaughtered at weeks 5, 7, 9 and 11 post-infection. Results demonstrated responses to fluke antigens and cytokine production (IFNgamma) from weeks 2-5 post-infection. These findings may suggest an early stimulation of IFNgamma production by peripheral blood lymphocytes following infection with F hepatica in cattle.
Clery
D G
DG
Department of Veterinary Microbiology and Parasitology, University College Dublin, Ballsbridge, Ireland.
Mulcahy
G
G
D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology*; D003208:Concanavalin A; D016207:Cytokines / Q000096:biosynthesis*; D005210:Fasciola hepatica / Q000254:growth & development* / Q000276:immunology; D005211:Fascioliasis / Q000276:immunology / Q000662:veterinary*; D007371:Interferon-gamma / Q000096:biosynthesis*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*
D000947:Antigens, Helminth; D016207:Cytokines; D003208:Concanavalin A; D007371:Interferon-gamma