title: Recent developments for the efficient crystallographic refinement of macromolecular structures.
abstract: Macromolecular crystallographic refinement has recently been made more efficient by the use of cross-validated maximum likelihood targets and torsion-angle molecular dynamics simulated annealing. In combination with automated model building methods, the amount of manual intervention required to complete and refine a structure is greatly reduced.
authors.affiliation: Howard Hughes Medical Institute, Yale University, New Haven, CT 06511, USA. brunger@laplace.csb.yale.edu
authors.forename: A T
authors.initials: AT
authors.lastname: Brünger
authors.forename: P D
authors.initials: PD
authors.lastname: Adams
authors.forename: L M
authors.initials: LM
authors.lastname: Rice
mesh_terms: D018360:Crystallography, X-Ray / Q000379:methods*; D016013:Likelihood Functions; D046911:Macromolecular Substances; D008956:Models, Chemical; D008958:Models, Molecular
chemical_list: D046911:Macromolecular Substances