Evaluation of morphological changes after treatment with coenzyme Q10 (CoQ10) in endothelin-1 induced experimental ischemia in the rat.
The aim of the work was to evaluate the effect of CoQ10 (10 mg/kg body weight) on the morphological changes in the rat brain after the Et-1 induced cerebral ischemia. Selective necrotic foci and dark neurons were observed in the cerebral cortex, hippocampal CA1, CA2 sectors and dentate gyrus after the administration of Et-1. Around the necrotic foci, glycogen was deposited 24 hours after the ischemic hypoxia. It seems that histopathological changes evoked by Et-1 indicate the complicated mechanism connected with ischemia. After treatment with CoQ10 only sparse neuronal changes were observed. CoQ10, known oxygen-derived free radicals scavenger diminished neuronal damage in the cerebral cortex and in the hippocampus.
Ostrowski
R P
RP
Department of Neuropathology, Polish Academy of Sciences, Warszawa.
Piotrowski
P
P
Pańkowska
T
T
Smiałek
M
M
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000473:pathology; D002545:Brain Ischemia / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D002540:Cerebral Cortex / Q000187:drug effects / Q000473:pathology; D018891:Dentate Gyrus / Q000187:drug effects / Q000473:pathology; D019332:Endothelin-1 / Q000633:toxicity*; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology; D008297:Male; D009474:Neurons / Q000473:pathology; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species; D014451:Ubiquinone / Q000494:pharmacology / Q000627:therapeutic use*
D019332:Endothelin-1; D018696:Neuroprotective Agents; D017382:Reactive Oxygen Species; D014451:Ubiquinone