Interference of myrtol standardized with inflammatory and allergic mediators.
Myrtol standardized (Gelomyrtol/Gelomyrtol forte) inhibits the activity of 5-lipoxygenase of human basophil and eosinophil leukocytes and the formation of leukotriene C4 as well as 1.8-cineole (eucalyptol). An increase of prostaglandins (PGE2) in mucous membranes of teat cisterns after topical administration of TPA (tetradecanoylphorbol-13-acetate) was inhibited. In vitro and in vivo studies revealed spasmolytic and broncholytic effects of Myrtol stand. After topical administration into the teat cisterns of the isolated bovine udder Myrtol stand. increased the surface temperature, comparable to effects of menthol.
Beuscher
N
N
G. Pohl-Boskamp GmbH & Co., Hohenlockstedt, Germany.
Kietzmann
M
M
Bien
E
E
Champeroux
P
P
D000818:Animals; D001094:Arachidonate 5-Lipoxygenase / Q000378:metabolism*; D016718:Arachidonic Acid / Q000494:pharmacology; D001491:Basophils / Q000201:enzymology; D002417:Cattle; D003511:Cyclohexanols; D015232:Dinoprostone / Q000378:metabolism; D004338:Drug Combinations; D004347:Drug Interactions; D004804:Eosinophils / Q000201:enzymology; D000077591:Eucalyptol; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D006940:Hyperemia; D066298:In Vitro Techniques; D007249:Inflammation; D015471:Leukemia, Basophilic, Acute; D017997:Leukotriene C4 / Q000378:metabolism; D017998:Leukotriene D4 / Q000378:metabolism; D017999:Leukotriene E4 / Q000378:metabolism; D008297:Male; D008321:Mammary Glands, Animal / Q000187:drug effects / Q000502:physiology*; D008610:Menthol / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D051379:Mice; D039821:Monoterpenes; D009092:Mucous Membrane / Q000187:drug effects / Q000502:physiology; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D013729:Terpenes / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014132:Trachea; D014407:Tumor Cells, Cultured
D003511:Cyclohexanols; D004338:Drug Combinations; D039821:Monoterpenes; D013729:Terpenes; C016469:gelomyrtol; D008610:Menthol; D016718:Arachidonic Acid; D017997:Leukotriene C4; D017998:Leukotriene D4; D017999:Leukotriene E4; D001094:Arachidonate 5-Lipoxygenase; D015232:Dinoprostone; D013755:Tetradecanoylphorbol Acetate; D000077591:Eucalyptol