title: Local GABA circuit control of experience-dependent plasticity in developing visual cortex.
abstract: Sensory experience in early life shapes the mammalian brain. An impairment in the activity-dependent refinement of functional connections within developing visual cortex was identified here in a mouse model. Gene-targeted disruption of one isoform of glutamic acid decarboxylase prevented the competitive loss of responsiveness to an eye briefly deprived of vision, without affecting cooperative mechanisms of synapse modification in vitro. Selective, use-dependent enhancement of fast intracortical inhibitory transmission with benzodiazepines restored plasticity in vivo, rescuing the genetic defect. Specific networks of inhibitory interneurons intrinsic to visual cortex may detect perturbations in sensory input to drive experience-dependent plasticity during development.
authors.affiliation: Laboratory for Neuronal Circuit Development, Brain Science Institute RIKEN, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan. hensch@postman.riken.go.jp
authors.forename: T K
authors.initials: TK
authors.lastname: Hensch
authors.forename: M
authors.initials: M
authors.lastname: Fagiolini
authors.forename: N
authors.initials: N
authors.lastname: Mataga
authors.forename: M P
authors.initials: MP
authors.lastname: Stryker
authors.forename: S
authors.initials: S
authors.lastname: Baekkeskov
authors.forename: S F
authors.initials: SF
authors.lastname: Kash
mesh_terms: D000818:Animals; D003975:Diazepam / Q000494:pharmacology; D018757:GABA Modulators / Q000494:pharmacology; D018390:Gene Targeting; D005968:Glutamate Decarboxylase / Q000235:genetics / Q000378:metabolism*; D007395:Interneurons / Q000502:physiology*; D017774:Long-Term Potentiation; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009473:Neuronal Plasticity / Q000187:drug effects; D010775:Photic Stimulation; D011963:Receptors, GABA-A / Q000378:metabolism; D009435:Synaptic Transmission; D014793:Visual Cortex / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D014795:Visual Pathways; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D018757:GABA Modulators; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; D005968:Glutamate Decarboxylase; D003975:Diazepam