title: Clozapine effects on force control in schizophrenic patients.
abstract: We previously reported significant differences in force control (FC) function between schizophrenics treated with typical antipsychotic drugs (APD) and those treated with clozapine. Clozapine treatment was associated with an attenuation of the capacity for fine motor control. We now report that a test-retest study with 41 treatment-refractory patients confirms our earlier finding; the FC deficit is due primarily to clozapine treatment. An additional comparison was made with 10 patients who were administered the FC test repeatedly through the initial clozapine titration interval of 6-8 weeks. The results suggest that two distinct clozapine effects can be distinguished, an initial transient stage characterized by 'drowsiness' and a subsequent stage with dose-dependent emerging myoclonic features.
authors.affiliation: Cleveland VA Medical Center, Brecksville, OH 44141, USA. vrtunski.p_bart@cleveland.va.gov
authors.forename: P B
authors.initials: PB
authors.lastname: Vrtunski
authors.forename: P E
authors.initials: PE
authors.lastname: Konicki
authors.forename: G E
authors.initials: GE
authors.lastname: Jaskiw
authors.forename: D W
authors.initials: DW
authors.lastname: Brescan
authors.forename: K Y
authors.initials: KY
authors.lastname: Kwon
authors.forename: G
authors.initials: G
authors.lastname: Jurjus
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D014150:Antipsychotic Agents / Q000009:adverse effects*; D003024:Clozapine / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004831:Epilepsies, Myoclonic / Q000139:chemically induced; D005260:Female; D006801:Humans; D008297:Male; D011597:Psychomotor Performance / Q000187:drug effects*; D012559:Schizophrenia / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine