Preparation and cytotoxic effect of ceanothic acid derivatives.
Six ceanothane and 1-norceanothane derivatives (1, 2, 8-11) were prepared from ceanothic acid dibenzyl ester. These ring-A homologues of betulinic acid exhibited cytotoxic effects. Among these, 1-decarboxy-3-oxo-ceanothic acid (2) was found to be the most cytotoxic against OVCAR-3 and HeLa cancer cell lines, with an IC50 of 2.8 and 6.6 microg/mL, respectively, and an IC50 of 11.3 microg/mL against normal cell line FS-5.
Lee
S S
SS
School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China. shoeilee@ha.mc.ntu.edu.tw
Chen
W C
WC
Huang
C F
CF
Su
Y
Y
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009654:Norsteroids / Q000302:isolation & purification / Q000494:pharmacology*; D053978:Pentacyclic Triterpenes; D010946:Plants, Medicinal / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D014315:Triterpenes / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D000094062:Betulinic Acid
D000972:Antineoplastic Agents, Phytogenic; D009654:Norsteroids; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; C107972:ceanothic acid; D000094062:Betulinic Acid