title: Antibiotic resistance in bacterial urinary tract infections, 1991 to 1997.
abstract: This study assessed changing patterns of antibiotic resistance in Escherichia coli urinary tract infections at a university student health center during three periods: the first 6 months each of 1991, 1994, and 1997. Urine culture and sensitivity results were taken from available medical records of female patients having urine cultures during the three periods (1991, n = 739; 1994, n = 938; 1997, n = 863); age and ethnicity were also noted. In E. coli isolates (the majority of positive cultures), resistance to four antibiotics changed significantly: ampicillin (30% to 45% to 39%), carbenicillin (29% to 42% to 39%), tetracycline (29% to 40% to 23%), and trimethoprim/sulfamethoxazole (15% to 32% to 15%). The results raise questions regarding the future clinical reliability of several commonly used antibiotics in the treatment of urinary tract infection.
authors.affiliation: Department of Epidemiology, UCLA School of Public Health, USA. idyer@deltanet.com
authors.forename: I E
authors.initials: IE
authors.lastname: Dyer
authors.forename: T M
authors.initials: TM
authors.lastname: Sankary
authors.forename: J A
authors.initials: JA
authors.lastname: Dawson
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000668:Ampicillin Resistance; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002228:Carbenicillin / Q000627:therapeutic use; D018550:Cephalosporin Resistance; D002512:Cephalothin / Q000627:therapeutic use; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects*; D004927:Escherichia coli Infections / Q000188:drug therapy*; D005006:Ethnicity; D005260:Female; D006801:Humans; D015141:Los Angeles; D010403:Penicillin Resistance; D015203:Reproducibility of Results; D012189:Retrospective Studies; D013333:Student Health Services; D013753:Tetracycline Resistance; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use; D014552:Urinary Tract Infections / Q000188:drug therapy*; D014556:Urine / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D002228:Carbenicillin; D002512:Cephalothin