Hypercalcemia in malignant paraganglioma due to parathyroid hormone-related protein.
A 15-year-old boy had hypercalcemia in association with malignant retroperitoneal paraganglioma. He had suppressed circulating levels of intact parathyroid hormone, whereas parathyroid hormone-related protein (PTHrP) immunoreactivity was elevated in plasma. Both the serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels were normal. Preoperatively the patient required control of hypercalcemia with intravenous pamidronate therapy. His circulating calcium and PTHrP concentrations became normal after a successful surgical resection of the primary retroperitoneal tumor. To our knowledge, this is the first reported case of elevated PtHrP levels in a patient with paraganglioma which resolved postoperatively.
Loh
K
K
Division of Endocrinology and Metabolism, University of California, San Francisco, Calif., USA. keh_chuan_loh@notes.ttsh.gov.sg
Matthay
K K
KK
Hoover
M
M
Bracho
F A
FA
Cortez
A B
AB
Conte
F A
FA
Albanese
C T
CT
Miller
T R
TR
Price
D C
DC
Flores
A J
AJ
Kaviani
A
A
Shoback
D
D
D000293:Adolescent; D004164:Diphosphonates / Q000627:therapeutic use; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology* / Q000628:therapy; D008297:Male; D000077268:Pamidronate; D010235:Paraganglioma / Q000097:blood / Q000150:complications* / Q000601:surgery; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins / Q000378:metabolism*; D012186:Retroperitoneal Neoplasms / Q000097:blood / Q000150:complications* / Q000601:surgery; D014057:Tomography, X-Ray Computed
D004164:Diphosphonates; C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins; D000077268:Pamidronate