Case-control study on breast cancer and adipose tissue concentrations of congener specific polychlorinated biphenyls, DDE and hexachlorobenzene.
In a case-control study on 43 patients operated for invasive breast cancer (cases) and 35 patients operated for benign breast disease (controls) adipose tissue concentrations of polychlorinated biphenyls (PCBs), 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) and hexachlorobenzene (HCB) were investigated. Approximately 10 g of breast tissue free from tumour was taken and frozen until analysis. No significant difference for the sum of non co-planar PCBs or DDE was found between cases and controls. For postmenopausal women the odds ratio (OR) was increased for co-planar PCB #77 > 4.5 pg/g lipid (OR = 5.8, 95% confidence interval (CI) = 0.8-42), PCB #126 > 145 pg/g lipid (OR = 2.2, 95% CI = 0.2-18), PCB #169 > 90 pg/g lipid (OR = 7.8, 95% CI = 0.6-96), and for HCB > 40 ng/g lipid (OR = 1.9, 95% CI = 0.4-7.2) adjusted for age and parity. The risk increased further for postmenopausal women with oestrogen receptor positive tumours yielding for PCB #77 adjusted OR 33 (95% CI 1.8-588), PCB #126 OR not calculable (no unexposed cases), PCB #169 OR 8.6 (95% CI 0.5-136) and hexachlorobenzene OR 7.1 (95% CI 1.1-45). Also for the sum of PCB > 1230 ng/g lipid adjusted OR increased to 1.8 (95% CI 0.4-7.3) whereas the results were similar for DDE.
Liljegren
G
G
Department of Surgery, Orebro Medical Centre, Sweden.
Hardell
L
L
Lindström
G
G
Dahl
P
P
Magnuson
A
A
D000273:Adipose Tissue / Q000737:chemistry*; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D016022:Case-Control Studies; D003633:Dichlorodiphenyl Dichloroethylene / Q000009:adverse effects* / Q000032:analysis; D005260:Female; D005659:Fungicides, Industrial / Q000009:adverse effects* / Q000032:analysis; D006581:Hexachlorobenzene / Q000009:adverse effects* / Q000032:analysis; D006801:Humans; D007306:Insecticides / Q000009:adverse effects* / Q000032:analysis; D008593:Menopause; D008875:Middle Aged; D011078:Polychlorinated Biphenyls / Q000009:adverse effects* / Q000032:analysis; D012307:Risk Factors; D014018:Tissue Distribution
D005659:Fungicides, Industrial; D007306:Insecticides; D003633:Dichlorodiphenyl Dichloroethylene; D006581:Hexachlorobenzene; D011078:Polychlorinated Biphenyls