title: Diagnostic value of nasal provocation challenge with allergens in children.
abstract: A total of 106 children suffering from perennial rhinitis and/or asthma, and all allergic to Dermatophagoides pteronyssinus (DP), underwent nasal provocation challenge (NPC) with DP to determine the best method of diagnosis. Posterior rhinomanometry was uninterpretable in 17 patients and gave negative results in 31. Clinical scores for sneezing and rhinorrhea were more effective but did not diagnose the disorder in 11 children. However, nine of the 11 had significant increases in eosinophil count in the late phase. Clinical scores and cytology were also useful for assessing whether NPC with allergens was positive in children. The feasibility and safety of NPC with DP are high for rhinitic and stable asthmatic patients, but mild reactions may occur during the late phase.
authors.affiliation: Service de Pneumologie et d'Allergologie Pédiatriques, Groupe Hospitalier Necker-Enfants Malades, Paris, France.
authors.forename: R
authors.initials: R
authors.lastname: Jean
authors.forename: P
authors.initials: P
authors.lastname: Rufin
authors.forename: A
authors.initials: A
authors.lastname: Pfister
authors.forename: P
authors.initials: P
authors.lastname: Landais
authors.forename: S
authors.initials: S
authors.lastname: Waernessyckle
authors.forename: J
authors.initials: J
authors.lastname: de Blic
authors.forename: P
authors.initials: P
authors.lastname: Scheinmann
mesh_terms: D000293:Adolescent; D000485:Allergens / Q000008:administration & dosage; D039741:Antigens, Dermatophagoides; D001249:Asthma / Q000175:diagnosis*; D002452:Cell Count; D002648:Child; D002675:Child, Preschool; D003231:Conjunctivitis; D003371:Cough; D004305:Dose-Response Relationship, Drug; D004804:Eosinophils / Q000166:cytology; D005260:Female; D006023:Glycoproteins / Q000008:administration & dosage; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced; D006969:Hypersensitivity, Immediate / Q000139:chemically induced; D008297:Male; D008365:Manometry; D009093:Mucus / Q000166:cytology; D009297:Nasal Mucosa / Q000378:metabolism; D015508:Nasal Obstruction; D009299:Nasal Provocation Tests / Q000379:methods*; D010612:Pharyngitis; D011237:Predictive Value of Tests; D011537:Pruritus; D012221:Rhinitis, Allergic, Perennial / Q000175:diagnosis*; D012912:Sneezing; D013997:Time Factors
chemical_list: D000485:Allergens; D039741:Antigens, Dermatophagoides; D006023:Glycoproteins