[Changes in intraoperative blood glucose and ketone body concentrations during the repair of lipomyelomeningocele in children].
Blood glucose and ketone body (3-hydroxy-butyrate) concentrations were measured in 8 children (4.2 +/- 2.8 years old) during the repair of lipomyelomeningocele (9.0 +/- 2.6 hours) to elucidate whether lipid mobilization can be prevented by glucose infusion at the rate of 0.2 +/- 0.05 g.kg-1.h-1. The operation was followed in about 4 hours by a significant increase in blood glucose and ketone body concentrations, with their maximum value of 195 +/- 75 mg.dl-1 and 656 +/- 75 mumol.l-1, respectively (P < 0.05), as compared with the preoperative level. The lipid mobilization soon returned to normal state by increasing the rate of glucose infusion, as indicated by ketone body level of 92 +/- 58 mumol.l-1 at the end of operation. These results show that glucose infusion rate should be adjusted based on serial analysis of both blood sugar and ketone body concentrations in the anesthetic management of children undergoing a long operation.
Nonogaki
M
M
Department of Anesthesiology, Yokkaichi City Hospital.
Wakamatsu
M
M
Iwata
A
A
Okamoto
M
M
D020155:3-Hydroxybutyric Acid / Q000097:blood*; D000768:Anesthesia, General; D001786:Blood Glucose / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D007657:Ketone Bodies / Q000097:blood*; D050356:Lipid Metabolism; D008067:Lipoma / Q000601:surgery*; D008297:Male; D008577:Meningeal Neoplasms / Q000601:surgery*; D008591:Meningomyelocele / Q000601:surgery*; D016343:Monitoring, Intraoperative
D001786:Blood Glucose; D007657:Ketone Bodies; D005947:Glucose; D020155:3-Hydroxybutyric Acid