Vertebrate segmentation: the clock is linked to Notch signalling.
The periodic formation of somites during vertebrate segmentation has been suggested to involve a molecular 'segmentation clock'. Recent observations of cyclic Lunatic fringe expression in chick and mouse embryos link the segmentation clock to Delta-Notch signalling.
Jiang
Y J
YJ
Vertebrate Development Laboratory Imperial Cancer Research Fund 44 Lincoln's Inn Fields London WC2A 3PX UK.
Smithers
L
L
Lewis
J
J
D000818:Animals; D030161:Avian Proteins; D001683:Biological Clocks; D019521:Body Patterning / Q000235:genetics / Q000502:physiology*; D002642:Chick Embryo; D018507:Gene Expression Regulation, Developmental; D016695:Glycosyltransferases; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology*; D051379:Mice; D011506:Proteins / Q000235:genetics / Q000502:physiology; D051880:Receptors, Notch; D015398:Signal Transduction; D019170:Somites / Q000166:cytology
D030161:Avian Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D011506:Proteins; D051880:Receptors, Notch; C064045:delta protein; D016695:Glycosyltransferases; C498394:LFNG protein, Gallus gallus; C498392:Lfng protein, mouse