Heat-sensitive liposomes containing cisplatin and localized hyperthermia in treatment of murine tumor.
Combined therapy with heat-sensitive liposomes as carriers for drugs and local hyperthermia is thought to improve the local control rate. I studied the antitumor effects and concentrations of CDDP encapsulated in heat-sensitive liposomes (LIP-CDDP) in vivo. LIP-CDDP or CDDP-solution was given to 8 week-old male C3H/He mice bearing SCC VII tumors by tail vein injection, and tumors were heated at 40 degrees C or 42 degrees C. The concentration of LIP-CDDP in blood was significantly higher than that of CDDP-solution. The concentration in tumors after heating at 42 degrees C increased with heating time, but the concentration in tumors without heating or after heating at 40 degrees C did not show these changes. After heating at 42 degrees C, antitumor effects of LIP-CDDP were significantly better than those obtained with the use of CDDP-solution. Heating at 40 degrees C did not alter the antitumor effect of LIP-CDDP. Therefore, LIP-CDDP proved to be very effective when combined with local hyperthermia at 42 degrees C.
Nishita
T
T
Department of Radiology, Osaka City University Medical School, Japan.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000628:therapy*; D002945:Cisplatin / Q000008:administration & dosage* / Q000627:therapeutic use; D004337:Drug Carriers; D006358:Hot Temperature; D006979:Hyperthermia, Induced; D008081:Liposomes; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009374:Neoplasms, Experimental / Q000628:therapy
D000970:Antineoplastic Agents; D004337:Drug Carriers; D008081:Liposomes; D002945:Cisplatin