title: Human immunodeficiency virus-associated vision loss: electroretinogram attenuation.
abstract: OBJECTIVE
  To report a 35-year-old man with human immunodeficiency virus (HIV) and bilateral progressive decrease in vision thought to be caused by HIV optic neuropathy but associated with a severe attenuation of the electroretinogram.
  
  
  METHODS
  Case report, review of laboratory studies, visual fields, and electroretinogram.
  
  
  RESULTS
  Visual function deteriorated in an asymmetric fashion over 9 months of follow-up and continued to deteriorate, even when the patient had no detectable viral load. No evidence of cytomegalovirus retinitis or HIV retinopathy was present. An electroretinogram showed severe attenuation of both rod and cone-mediated functions.
  
  
  CONCLUSIONS
  In addition to producing retinal ganglion cell axonal degeneration, HIV may also damage the other retinal elements. The progression of visual loss in the absence of detectable virus has implications for the pathogenesis and prognosis of HIV-associated vision loss.
authors.affiliation: Department of Ophthalmology & Visual Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
authors.forename: S P
authors.initials: SP
authors.lastname: Donahue
mesh_terms: D000328:Adult; D018791:CD4 Lymphocyte Count; D018450:Disease Progression; D004596:Electroretinography; D015828:Eye Infections, Viral / Q000209:etiology* / Q000503:physiopathology; D006678:HIV / Q000502:physiology; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D017949:Retinal Cone Photoreceptor Cells / Q000503:physiopathology*; D012164:Retinal Diseases / Q000209:etiology* / Q000503:physiopathology; D017948:Retinal Rod Photoreceptor Cells / Q000503:physiopathology*; D019562:Viral Load; D014786:Vision Disorders / Q000209:etiology* / Q000503:physiopathology; D014792:Visual Acuity