Effect of the beta 1-blocker/beta 2-agonist celiprolol on atrial natriuretic peptide plasma levels in hypertensive patients.
The aim of this study was to evaluate the long-term effects of the selective beta 1-blocker/beta 2-agonist celiprolol on atrial natriuretic peptide (ANP) levels in patients with moderate essential hypertension. The drug was given orally in a daily dose of 200 mg for 30 days. Plasma ANP levels increased by 187% despite the drop in blood pressure, while left atrial and ventricular diameters remained unchanged. These findings indicate that ANP secretion, which is mediated by beta 1-receptor blockade, is not affected by stimulation of the vasodilatory beta 2-receptors. There is strong evidence suggesting that beta-blockers exert part of their antihypertensive action by increasing ANP secretion.
Papadopoulos
C L
CL
Department of Cardiology 2nd, Medical School, Aristotle University of Thessaloniki, Greece.
Kokkas
B
B
Kotridis
P
P
Karamouzis
M
M
Haldoupi
M
M
Platis
A
A
Dadoush
G
G
Kanonidis
I
I
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D000959:Antihypertensive Agents / Q000494:pharmacology*; D009320:Atrial Natriuretic Factor / Q000097:blood*; D001794:Blood Pressure; D017272:Celiprolol / Q000494:pharmacology*; D006339:Heart Rate; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008297:Male; D008875:Middle Aged
D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D009320:Atrial Natriuretic Factor; D017272:Celiprolol