The effects of nicotine on spatial and non-spatial expectancies in a covert orienting task.
The present study examined how nicotine influences shifts of visuo spatial attention in casual smokers at each of three delays after smoking one cigarette: immediately, 1 h and 24 h. Informative peripheral cues were used to exogenously orient attention to the location where an increase or decrease in the size of a peripheral object was most likely to occur. One size change was more likely to occur than the other and the task was choice (expansion/contraction) reaction time. The performance decrement obtained when the target appeared at an uncued location was smallest in sessions run immediately after smoking (when nicotine levels were highest), suggesting that nicotine may increase the ease with which attention can be disengaged from a cued location. This finding confirms previous research which suggests a specific role for the basal forebrain cholinergic system in visual orienting. In contrast, nicotine was not found to affect non-spatial expectancies based on stimulus-response (expansion/contraction) probability. These findings, together with recent converging evidence, strongly support the proposition that different attentional operations are mediated by different neural subsystems.
Murphy
F C
FC
Department of Psychiatry, University of Cambridge, Addenbrooke's Hospital, UK.
Klein
R M
RM
D000328:Adult; D000704:Analysis of Variance; D001288:Attention / Q000187:drug effects*; D001364:Awareness / Q000187:drug effects; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D008297:Male; D009415:Nerve Net; D009538:Nicotine / Q000494:pharmacology; D009949:Orientation; D011597:Psychomotor Performance / Q000187:drug effects*; D011930:Reaction Time / Q000187:drug effects; D017603:Signal Detection, Psychological / Q000187:drug effects; D012907:Smoking / Q000503:physiopathology*; D013028:Space Perception / Q000187:drug effects; D014796:Visual Perception / Q000187:drug effects*
D009538:Nicotine