Ten minute 13C-urea breath test for the diagnosis of Helicobacter pylori infection.
We investigated the utility of a 10-min 13C-urea breath test (13C-UBT) using 100mg of 13C-urea; this is a simple and rapid method for the detection of Helicobacter pylori infection. One hundred and fifty-one patients in whom the identification of H. pylori was established by rapid urease test, culture, and histology of six biopsy specimens underwent 254 13C-UBT examinations before and/or after eradication treatment. In the 133 patients who did not receive eradication treatment, the calculated sensitivity of the 10-min 13C-UBT was 99.4% and specificity 100% when the cut-off point was set at 3.5/1000, using a mass spectrometer. In the 121 patients who received eradication treatment, this cut-off point gave a sensitivity of 86.7%, a specificity of 99.1%, and a positive predictive value of 92.9%, with a negative predictive value of 98.1%. There were no significant differences between the diagnosis of H. pylori infection at 1 month and more than 3 months after the endpoint of eradication treatment. The 10-min 13C-UBT is suitable for the diagnosis of H. pylori infection before and after eradication treatment.
Kato
M
M
Third Department of Internal Medicine, Hokkaido University School of Medicine, Sapporo, Japan.
Asaka
M
M
Kudo
T
T
Katagiri
M
M
Komatsu
Y
Y
Sato
F
F
Sukegawa
M
M
Kobayashi
T
T
Kagaya
H
H
Nishikawa
K
K
Kudo
M
M
Hokari
K
K
Hige
S
S
Watanabe
M
M
Takeda
H
H
Sugiyama
T
T
D001944:Breath Tests; D002247:Carbon Isotopes; D005260:Female; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D008297:Male; D012680:Sensitivity and Specificity; D013272:Stomach Diseases / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D014508:Urea / Q000378:metabolism*
D002247:Carbon Isotopes; D014508:Urea