CD40 and epithelial cells: across the great divide.
The widespread expression of CD40 in normal epithelial cells and carcinoma cells suggests that this receptor has important, additional influences beyond that of regulating immune responses. Here, Lawrence Young and colleagues discuss the effect of CD40 ligation on epithelial cells and consider the role of this pathway in the pathogenesis and treatment of carcinomas.
Young
L S
LS
CRC Institute for Cancer Studies, University of Birmingham Medical School, UK. L.S.Young@bham.ac.uk
Eliopoulos
A G
AG
Gallagher
N J
NJ
Dawson
C W
CW
D000818:Animals; D000956:Antigens, Viral; D019013:CD40 Antigens / Q000502:physiology*; D002277:Carcinoma / Q000276:immunology; D004847:Epithelial Cells / Q000276:immunology*; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D008565:Membrane Proteins / Q000276:immunology; D051379:Mice; D018345:Mice, Knockout; D018716:Molecular Mimicry / Q000276:immunology; D015398:Signal Transduction; D014763:Viral Matrix Proteins / Q000276:immunology
D000956:Antigens, Viral; D019013:CD40 Antigens; C037662:EBV-associated membrane antigen, Epstein-Barr virus; D008565:Membrane Proteins; D014763:Viral Matrix Proteins