Synthesis and pharmacological screening of pyrazolo[3,4-c]pyridazine derivatives.
Ethyl 3-chloro-6-(4-chlorophenyl)-pyridazine-4-carboxylate [VII] was cyclized with some nucleophilic reagents (hydrazine hydrate or N-monosubstituted hydrazines) to the new derivatives of pyrazolo[3,4-c]pyridazine [IXa-d]. The structures of the novel compounds were confirmed by elemental and spectral analyses. The effect of several synthesized derivatives on the central nervous system was studied.
Zabska
R
R
Department of Chemistry of Drugs, Wrocław University of Medicine, Poland.
Kołodziejczyk
A
A
Sieklucka-Dziuba
M
M
Morawska
D
D
Kleinrok
Z
Z
D000661:Amphetamine / Q000037:antagonists & inhibitors; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects; D002491:Central Nervous System Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000697:Central Nervous System Stimulants / Q000037:antagonists & inhibitors; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D000927:Anticonvulsants; D002491:Central Nervous System Agents; D000697:Central Nervous System Stimulants; D011724:Pyridazines; D000661:Amphetamine