title: Does radiofrequency ablation induce a prethrombotic state? Analysis of coagulation system activation and comparison to electrophysiologic study.
abstract: BACKGROUND
  Although thromboembolism is an uncommon complication of radiofrequency (RF) ablation, some preliminary reports have suggested that RF ablation results in activation of the coagulation system, possibly increasing this risk. We hypothesized that the insertion of intravenous catheters and their prolonged intravenous placement rather than RF ablation activates the coagulation cascade.
  
  
  RESULTS
  Thirty-seven patients, group 1 (n = 21) during RF ablation, and group 2 (n = 16) during routine electrophysiologic studies (EPS), were studied prospectively. Blood was drawn for coagulation and fibrinolytic studies following insertion of venous sheaths (T0), following catheter placement (T1), and 1 hour after completion of RF ablation or EPS (T2). Conversion of prothrombin to thrombin was measured using thrombin-antithrombin complex (TAT) and prothrombin activation peptide (F1+2), and fibrinolytic activity was assessed using D-dimer concentration. Levels of D-dimer increased in group 1 from 823.52+/-323.52 ng/mL at T0 to 1,314.28+/-297.63 ng/mL at T2 (P = 0.005), and in group 2 from 658.15+/-161.70 ng/mL at T0 to 1625+/-641.45 ng/mL at T2 (P = 0.064). TAT levels increased from to 27.74+/-5.6 microg/L at T0 to 52.99+/-5.93 microg/L at T2 in group 1 (P = 0.09), and from 19.79+/-5.14 microg/L at T0 to 73.5+/-24.15 microg/L at T2 in group 2 (P = 0.05). F1+2 concentration increased from 1.52+/-0.30 nmol/L at T0 to 3.06+/-0.41 nmol/L at T2 in group 1 (P = 0.004), and from 1.32+/-0.30 nmol/L at T0 to 3.11+/-0.46 nmol/L at T2 in group 2 (P = 0.087). There was no significant difference in the concentration of the three coagulation variables between group 1 and group 2 at any given time point. No correlation was demonstrable between concentration of D-dimers, TAT, or F1+2 and variables of RF delivery such as cumulative energy, number of RF energy applications, or number of impedance rises. However, a significant positive correlation (r = 0.65, P<0.01) was noted between the duration of the RF ablation procedure and the concentration of D-dimers.
  
  
  CONCLUSIONS
  We conclude that activation of the coagulation cascade in RF ablation procedures is not related to the delivery of RF energy, but is related to the placement of intravascular catheters and to the duration of the ablation procedure.
authors.affiliation: St. Luke's-Roosevelt Hospital Center and Columbia University College of Physicians and Surgeons, New York, New York 10025, USA.
authors.forename: S
authors.initials: S
authors.lastname: Dorbala
authors.forename: A J
authors.initials: AJ
authors.lastname: Cohen
authors.forename: L A
authors.initials: LA
authors.lastname: Hutchinson
authors.forename: E
authors.initials: E
authors.lastname: Menchavez-Tan
authors.forename: J S
authors.initials: JS
authors.lastname: Steinberg
mesh_terms: D000328:Adult; D000991:Antithrombins / Q000378:metabolism; D015415:Biomarkers; D001777:Blood Coagulation / Q000502:physiology*; D006328:Cardiac Catheterization / Q000009:adverse effects; D017115:Catheter Ablation / Q000009:adverse effects*; D004594:Electrophysiology; D005260:Female; D005342:Fibrinolysis / Q000502:physiology; D006801:Humans; D008297:Male; D011516:Prothrombin / Q000378:metabolism; D013917:Thrombin / Q000096:biosynthesis; D013927:Thrombosis / Q000209:etiology*
chemical_list: D000991:Antithrombins; D015415:Biomarkers; D011516:Prothrombin; D013917:Thrombin