Xanthones from Hypericum japonicum and H. henryi.
From the aerial part of Hypericum japonicum, one new xanthone glycoside, 1,5-dihydroxyxanthone-6-O-beta-D-glucoside, one novel dimer xanthone, bijaponicaxanthone, and the first natural prenylated xanthone, 1,3,5,6-tetrahydroxy-4-prenylxanthone, were isolated together with the four known xanthones, 1,5,6-trihydroxyxanthone, isojacereubin, 6-deoxyisojacareubin and 4',5'-dihydro-1,5,6-trihydroxy-4',4',5'-trimethylfurano (2',3':4,5) xanthone. five previously known xanthones, kielcorin, cadensin, 1,7,-dihydroxyxanthone, 1,5-dihydroxy-4-methoxyxanthone and 1,2,5-trihydroxyxanthone were also found in the dichoromethane extract of the stems and leaves of H. henryi. Their structures were elucidated by spectroscopic and chemical methods. Some of the compounds from H. japonicum were found to exert an interesting coagulant activity in an in vitro test. The chemotaxonomic value of xanthones is discussed briefly.
Wu
Q L
QL
Institute of Medicinal Plant Development, Peking Union Medical College Beijing, P. R. China.
Wang
S P
SP
Du
L J
LJ
Yang
J S
JS
Xiao
P G
PG
D000818:Animals; D020448:Ericales / Q000737:chemistry* / Q000378:metabolism*; D008297:Male; D019906:Nuclear Magnetic Resonance, Biomolecular; D010084:Oxidation-Reduction; D010936:Plant Extracts / Q000302:isolation & purification* / Q000378:metabolism* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet; D014966:Xanthenes / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D044004:Xanthones
D010936:Plant Extracts; D014966:Xanthenes; D044004:Xanthones; C009689:xanthone