title: Hepatobiliary cystadenoma can protrude and grow into the bile ducts.
abstract: OBJECTIVE
  To evaluate the phenomenon and the potential reasons for protrusion and growth of hepatobiliary cystadenoma into the extrahepatic bile ducts in our patients, accomplished by a review of the data regarding hepatobiliary cystadenomas published elsewhere.
  
  
  METHODS
  In a retrospective open study conducted over the last eight years, five patients with hepatobiliary cystadenoma and one patient with hepatobiliary cystadenocarcinoma were operated on. All the patients were females aged between 25 to 61 years. Diagnostic procedures, laboratory, operative and histopathological findings and treatment were evaluated.
  
  
  RESULTS
  Most of our patients were found to have hepatobiliary cystadenoma located in the left surgical liver. In three out of five patients with HBC mesenchymal stroma was histologically detected. In two of the three, protrusion and growth into the extrahepatic bile ducts was found.
  
  
  CONCLUSIONS
  Considering the pathogenesis, location and the morphology of HBC, the mesenchymal stroma may present the competent potential for intraductal progression of the tumor. Radical excision should be performed for successful treatment of hepatobiliary cystadenomas, because of the potential for reoccurrence.
authors.affiliation: University Medical Center, Department of Gastroenterologic Surgery, Ljubljana, Slovenia.
authors.forename: E M
authors.initials: EM
authors.lastname: Gadzijev
authors.forename: A
authors.initials: A
authors.lastname: Pleskovic
authors.forename: D
authors.initials: D
authors.lastname: Stanisavljevic
authors.forename: V
authors.initials: V
authors.lastname: Ferlan-Marolt
authors.forename: B
authors.initials: B
authors.lastname: Trotovsek
mesh_terms: D002759:Adenoma, Bile Duct / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D000328:Adult; D001650:Bile Duct Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D017734:Bile Ducts, Extrahepatic / Q000473:pathology; D001653:Bile Ducts, Intrahepatic; D018281:Cholangiocarcinoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D003536:Cystadenocarcinoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D003537:Cystadenoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011859:Radiography; D012189:Retrospective Studies