title: SCH56592 treatment of murine invasive aspergillosis.
abstract: Mice were immunosuppressed using corticosteroids and infected with conidia of Aspergillus fumigatus. Beginning 1 day after infection, mice were treated orally either with Noble agar or with SCH56592 suspended in Noble agar, or intraperitoneally with amphotericin B. SCH56592 prolonged survival and reduced lung tissue counts of A. fumigatus, while amphotericin B had marginal benefit. SCH56592 merits further development for treatment of aspergillosis.
authors.affiliation: The University of Texas Health Science Center at San Antonio, 78284, USA. Graybill@uthscsa.edu
authors.forename: J R
authors.initials: JR
authors.lastname: Graybill
authors.forename: R
authors.initials: R
authors.lastname: Bocanegra
authors.forename: L K
authors.initials: LK
authors.lastname: Najvar
authors.forename: M F
authors.initials: MF
authors.lastname: Luther
authors.forename: D
authors.initials: D
authors.lastname: Loebenberg
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D001228:Aspergillosis / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D001232:Aspergillus fumigatus; D015169:Colony Count, Microbial; D008168:Lung / Q000382:microbiology / Q000473:pathology; D008172:Lung Diseases, Fungal / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D014230:Triazoles / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole; D000666:Amphotericin B