Arteritis and fatal subarachnoid hemorrhage complicating occult Candida meningitis: unusual presentation in pediatric acquired immunodeficiency syndrome.
We report the case of an 11-month-old child with acquired immunodeficiency syndrome, who despite treatment for systemic candidiasis developed undetected Candida meningitis. This uncommon manifestation of candidiasis was accompanied by basilar granulomatous inflammation and fibrosis of meninges with arteritis, vascular invasion by fungi, and terminal subarachold hemorrhage. To our knowledge, this constellation of findings has not been reported previously in pediatric acquired immunodeficiency syndrome.
Rabah
R
R
Department of Pathology and Laboratory Medicine, Children's Hospital of Michigan, Detroit 48201, USA.
Kupsky
W J
WJ
Haas
J E
JE
D017088:AIDS-Related Opportunistic Infections / Q000382:microbiology* / Q000473:pathology; D001167:Arteritis / Q000382:microbiology* / Q000473:pathology; D002177:Candidiasis / Q000382:microbiology* / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007223:Infant; D016921:Meningitis, Fungal / Q000382:microbiology* / Q000473:pathology; D013345:Subarachnoid Hemorrhage / Q000382:microbiology* / Q000473:pathology