[Cutaneous Scedosporium infection revealed by bullous-necrotic purpura].
BACKGROUND
Non-mycetomatous cutaneous scedosprium is an uncommon mycosis observed in immunodepressed subjects. We report a case with an inaugural presentation of bullous and necrotic purpura.


METHODS
A 79-year-old man on intermittent corticosteroid therapy for bronchospasm was admitted for bullous and necrotic purpura and fever. Subcutaneous nodules with a sporotrichoid aspect developed despite wide-spectrum antibiotics. Microbiology samples cultured on Sabouraud medium evidenced Scedosporium apiospermum. The pathogenic nature of the infection was proven on a skin biopsy showing numerous myceleal filaments with Gomori-Grocott staining despite negative PAS. No pulmonary involvement was evidenced. The patient was treated unsuccessfully with itraconazole. A Pseudomonas lung infection was fatal.


CONCLUSIONS
Scedosporium apiospermum, an ubiquitous ascomycetes anamorphous to Pseudallescheria boydii, is the cause of a growing number of human infections due to widespread use of immunosuppressors. Skin and lung localizations predominate. The inaugural bullous and necrotic purpural skin manifestations in this case are unusual. In addition, the patient was only minimally immunodepressed and despite demonstrated in vitro sensitivity, itraconazole was ineffective clinically. Treatment is not well defined, but surgery is essential in combination with empirically chosen antifungals.
Lemerle
E
E
Service de Dermatologie-Vénéréologie, C.H. Le Mans.
Bastien
M
M
Demolliens-Dreux
G
G
Forest
J L
JL
Boyer
E
E
Chabasse
D
D
Célérier
P
P
D000368:Aged; D003881:Dermatomycoses / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008297:Male; D011541:Pseudallescheria; D011693:Purpura / Q000209:etiology*; D012867:Skin / Q000473:pathology
Scédosporiose cutanée révélée par un purpura bullo-nécrotique.