Selection for carriers of recessive diseases: a common phenomenon?
Several autosomal recessive disorders are present in high frequency in isolated populations because of either multiple allelic mutations or mutations in different genes. These observations are best explained by selection, which may be an important mechanism in the determination of the distribution of genetic disorders.
Zlotogora
J
J
Department of Human Genetics, Hadassah Medical Center, Hebrew University Jerusalem, Israel.
D005808:Genes, Recessive; D005901:Glaucoma / Q000151:congenital / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D007849:Laurence-Moon Syndrome / Q000235:genetics; D016464:Lysosomal Storage Diseases / Q000235:genetics; D009136:Muscular Dystrophies / Q000235:genetics; D012641:Selection, Genetic