Influence of trimedoxime bromide on degradation of benactyzine in acidic injectable solutions.
The stability of benactyzine in a multicomponent injectable antidote formulation in deuterium oxide was studied in the presence of various concentrations of trimedoxime bromide. Benactyzine was found to be more stable in the absence of trimedoxime bromide and its degradation rate accelerated linearly with increasing concentrations of trimedoxime bromide. The main reasons for the accelerated decomposition rate of benactyzine were found to be the nucleophilic effect of the bromide ion and the oxime moiety. For each trimedoxime concentration studied, t90 for benactyzine at 25 degrees C was calculated and was found to be 5.3-1.5 years within the concentrations range of 0-120 mg/ml. Rate constants and activation energies for benactyzine degradation were determined for each of the concentrations studied.
Rubnov
S
S
Medical Corps, Israeli Defence Force, Military P.O.B. 02149, Israel.
Amisar
S
S
Lomnicky
Y
Y
Schneider
H
H
D001535:Benactyzine / Q000737:chemistry*; D002801:Cholinesterase Reactivators / Q000737:chemistry*; D018727:Muscarinic Antagonists / Q000737:chemistry*; D019999:Pharmaceutical Solutions; D014289:Trimedoxime / Q000737:chemistry*
D002801:Cholinesterase Reactivators; D018727:Muscarinic Antagonists; D019999:Pharmaceutical Solutions; D014289:Trimedoxime; D001535:Benactyzine