title: N-Acyl-L-homoserine lactone autoinducers control production of an extracellular lipopeptide biosurfactant required for swarming motility of Serratia liquefaciens MG1.
abstract: A nonswarming Serratia liquefaciens mutant deficient in serrawettin W2 production was constructed by transposon mutagenesis. Sequence homology indicated that insertion had occurred in gene swrA, which encodes a putative peptide synthetase. Expression of swrA is controlled by quorum sensing.
authors.affiliation: Department of Microbiology, Technical University of Denmark, 2800 Lyngby, Denmark.
authors.forename: P W
authors.initials: PW
authors.lastname: Lindum
authors.forename: U
authors.initials: U
authors.lastname: Anthoni
authors.forename: C
authors.initials: C
authors.lastname: Christophersen
authors.forename: L
authors.initials: L
authors.lastname: Eberl
authors.forename: S
authors.initials: S
authors.lastname: Molin
authors.forename: M
authors.initials: M
authors.lastname: Givskov
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000502:physiology; D000595:Amino Acid Sequence; D002465:Cell Movement / Q000235:genetics / Q000502:physiology; D017124:Conserved Sequence; D005110:Extracellular Space / Q000502:physiology; D005798:Genes, Bacterial; D008074:Lipoproteins / Q000096:biosynthesis / Q000737:chemistry / Q000502:physiology*; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010453:Peptide Synthases / Q000235:genetics / Q000502:physiology; D010456:Peptides, Cyclic / Q000096:biosynthesis / Q000737:chemistry / Q000502:physiology*; D017386:Sequence Homology, Amino Acid; D012705:Serratia / Q000235:genetics / Q000502:physiology*; D013501:Surface-Active Agents / Q000737:chemistry / Q000378:metabolism*
chemical_list: D008074:Lipoproteins; C092312:N-butyrylhomoserine lactone; C104908:N-hexanoyl-L-homoserine lactone; D010456:Peptides, Cyclic; D013501:Surface-Active Agents; C073497:serrawettin W2; D010453:Peptide Synthases; D015107:4-Butyrolactone