title: No evidence for radiation-induced clastogenic factors after in vitro or in vivo exposure of human blood.
abstract: Experiments were performed with human plasma irradiated in vitro or in vivo in order to evaluate the extent to which clastogenic factors might disturb the adaptive response to DNA-damaging factors currently studied in our laboratory. The studies were carried out with plasma isolated from whole blood given 4 Gy of X-rays in vitro and with plasma from people receiving local radiotherapy at a total dose of about 60 Gy gamma rays. Addition of irradiated plasma to culture medium did not result in a statistically significant increase in structural aberrations in chromosomes of non-irradiated normal blood.
authors.affiliation: Teratogenicity and Mutagenicity Laboratory, Catholic University of Louvain, Avenue E. Mounier 72, UCL 7237, Brussels 1200, Belgium. leonard@farm.ucl.ac.be
authors.forename: A
authors.initials: A
authors.lastname: Léonard
authors.forename: E D
authors.initials: ED
authors.lastname: Léonard
authors.forename: G B
authors.initials: GB
authors.lastname: Gerber
authors.forename: M C
authors.initials: MC
authors.lastname: Crutzen-Fayt
authors.forename: F
authors.initials: F
authors.lastname: Richard
authors.forename: J G
authors.initials: JG
authors.lastname: Gueulette
authors.forename: N B
authors.initials: NB
authors.lastname: Akhmatullina
mesh_terms: D000017:ABO Blood-Group System; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D008297:Male; D010949:Plasma / Q000528:radiation effects*; D011879:Radiotherapy Dosage; D012204:Rh-Hr Blood-Group System
chemical_list: D000017:ABO Blood-Group System; D012204:Rh-Hr Blood-Group System