(+)-Verussurine, a new steroidal alkaloid from the roots and rhizomes of veratrum nigrum var. ussuriense and structure revision of (+)-verabenzoamine1
Two minor steroidal alkaloids, 1 and 2, have been isolated from the roots and rhizomes of Veratrum nigrum var. ussuriense. Their structures have been determined by the use of spectral data as 7-O-acetyl-15-O-(2-methylbutyroyl)-3-O-veratroylgermine (1) and 15-O-(2-methylbutyroyl)-3-O-veratroylgermine (2). By spectral data comparison with verabenzoamine, the structure of the latter compound has been revised from the previously reported 7-O-acetyl-15-O-(2-methylbutyroyl)-3-O-veratroylgermine (1) to 15-O-(2-methylbutyroyl)-3-O-veratroylgermine (2). Accordingly, alkaloid 1 [7-O-acetyl-15-O-(2-methylbutyroyl)-3-O-veratroylgermine] must be new, and it was given the trivial name verussurine.
Tezuka
Y
Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0152, Japan, and Research Institute for Medical and Pharmaceutical Science, Dalian, Chunyangji.
Kikuchi
T
Zhao
W
Chen
J
Guo
Y