[Platelet alloantigenic systems].
Platelet-specific alloantigen systems are located on glycoproteins expressed at the surface of platelet membrane. These di-allelic systems are due to an amino acid substitution. An official nomenclature was adopted in 1990 by the Working Party on Platelet Serology ICST/ISBT which defined the following rules: (1) platelet-specific antigen systems are called HPA for "Human Platelet Antigens"; (2) they are numbered chronologically according to the date of publication; (3) the most frequent allele is designated by the letter a and the less frequent by the letter b (i.e., HPA-1a 1b). Since the introduction of molecular biology techniques, the nomenclature has become insufficiently precise and an adjustment will probably be required in a near future.
Hallé
L
L
Institut national de la transfusion sanguine, Paris, France.
D016824:Antigens, Human Platelet / Q000737:chemistry / Q000145:classification*; D006801:Humans; D010980:Platelet Membrane Glycoproteins / Q000145:classification* / Q000276:immunology; D009626:Terminology as Topic
D016824:Antigens, Human Platelet; D010980:Platelet Membrane Glycoproteins
Les systèmes alloantigéniques plaquettaires.