[The effects of midazolam on oxygen consumption and the level of vigilance. The possibility of the sedative effect of the plexiglas dome (canopy) of the Deltatrac indirect calorimetry device].
OBJECTIVE
To assess the effects of midazolam on oxygen consumption (VO2) and the level of vigilance. To search for a possible "sedative effect" of the canopy of the Deltatrac (Datex) when a placebo is administered instead of midazolam.


METHODS
Prospective, comparative, randomized, double-blinded, cross-over study.


METHODS
Eight healthy volunteers of ASA physical class 1, not under stress, fasting and at rest.


METHODS
The volunteers were administered at T0 either midazolam (0.07 mg.kg-1, IM), or a placebo at a one week interval in an order at random. The VO2 was measured with a Deltatrac. Circulatory status was monitored with non invasive methods and the level of vigilance assessed using the Ramsay scale. Statistical analysis was obtained with Anova for repeated measurements with two within factors (drug and time).


RESULTS
VO2 decreased similarly and significantly between T0 and T45 min (P < 0.05). The decrease continued only after midazolam until T60 min. However the variation of VO2 between the midazolam and placebo group was not significant. The haemodynamic variables remained unchanged. Midazolam had a stronger sedative effect at T120 min.
Kerbaul
F
F
Département d'anesthésie-réanimation, CHU Timone, Marseille, France.
Dumont
J C
JC
Bruder
N
N
Auquier
P
P
François
G
G
D000328:Adult; D000704:Analysis of Variance; D001143:Arousal / Q000187:drug effects*; D001775:Blood Circulation / Q000187:drug effects; D002153:Calorimetry, Indirect / Q000295:instrumentation*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004867:Equipment Design; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D008874:Midazolam / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects*; D010919:Placebos; D019904:Polymethyl Methacrylate; D011446:Prospective Studies
D006993:Hypnotics and Sedatives; D010919:Placebos; D019904:Polymethyl Methacrylate; D008874:Midazolam
Effets du midazolam sur la consommation d'oxygène et le niveau de vigilance. Possibilité d'un effet sédatif de la bulle de plexiglas (canopy) du calorimètre indirect deltatrac.