title: Tissue adhesive versus suture wound repair at 1 year: randomized clinical trial correlating early, 3-month, and 1-year cosmetic outcome.
abstract: OBJECTIVE
  To compare the 1-year cosmetic outcome of wounds treated with octylcyanoacrylate tissue adhesive and monofilament sutures and to correlate the early, 3-month, and 1-year cosmetic outcomes.
  
  
  METHODS
  We prospectively randomized 136 cases of traumatic laceration to repair with octylcyanoacrylate tissue adhesive or 5-0 or smaller monofilament suture. A wound score was assigned by a research nurse, and validated by a second nurse blinded to the treatment, at 5 to 10 days after injury (early), 3 months, and 1 year. Standardized photographs were taken at 3 months and 1 year and shown to a cosmetic surgeon blinded to the method of closure, who rated the wounds on a validated cosmesis scale.
  
  
  RESULTS
  We were able to examine 77 lacerations at 1 year for follow-up. No differences were found in the demographic or clinical characteristics between groups. Likewise, at 1 year no difference was found in the optimal wound scores (73% versus 68%, P =.60) or in visual analog scale cosmesis scores (69 versus 69 mm, P =.95) for octylcyanoacrylate and sutures, respectively. Agreement was poor between early and 3-month wound scores (kappa=.34; 95% confidence interval [CI],.10 to.58) but a strong association existed between 3-month and 1-year wound scores (kappa=.71; 95% CI,.52 to.90). We noted a moderate correlation between 3-month and 1-year results on the visual analog cosmesis scale (intraclass correlation,.48; 95% CI, .30 to.63).
  
  
  CONCLUSIONS
  One year after wound repair, no difference is noted in the cosmetic outcomes of traumatic lacerations treated with octylcyanoacrylate tissue adhesive and sutures. The assessment of wounds 3 months after injury and wound repair provides a good measure of long-term cosmetic outcome.
authors.affiliation: Section of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA. quinnj@medicine.ucsf.edu
authors.forename: J
authors.initials: J
authors.lastname: Quinn
authors.forename: G
authors.initials: G
authors.lastname: Wells
authors.forename: T
authors.initials: T
authors.lastname: Sutcliffe
authors.forename: M
authors.initials: M
authors.lastname: Jarmuske
authors.forename: J
authors.initials: J
authors.lastname: Maw
authors.forename: I
authors.initials: I
authors.lastname: Stiell
authors.forename: P
authors.initials: P
authors.lastname: Johns
mesh_terms: D000328:Adult; D001504:Beauty; D003487:Cyanoacrylates / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D016037:Single-Blind Method; D013536:Suture Techniques / Q000592:standards*; D013997:Time Factors; D016896:Treatment Outcome; D014945:Wound Healing; D014950:Wounds, Penetrating / Q000628:therapy*
chemical_list: D003487:Cyanoacrylates