title: Influence of HIV-1 infection on GBV-C infection in multiply infected haemophilic patients.
abstract: Two hundred thirteen haemophilic patients were studied for the presence of GBV-C RNA and anti-E2 antibodies soon after their first treatment with unsterilised factor concentrates and in their most recent sample. An assessment was made to determine whether coinfection with HIV had any effect on the progression of GBV-C infection. All of the patients were infected with HCV and 81 patients (37%) were also infected with HIV. GBV-C RNA was detected using the Abbott LCx(TM) assay and by RT-PCR. Anti-E2 antibodies were detected using the microPLATE Anti-HGenv assay and by Abbott Laboratories. The HIV-negative patients were more likely than the HIV-positive patients to lose GBV-C RNA between the two time points. A proportion of the patients lost their anti-E2 antibodies over the time period, however, the majority of these were HIV-positive. This study shows that infection with HIV does affect the progression of GBV-C infection, however, this effect is little understood as yet.
authors.affiliation: Department of Retrovirology, Royal Free Hospital, London, England. devereaux@rfhsm.ac.uk
authors.forename: H
authors.initials: H
authors.lastname: Devereux
authors.forename: C A
authors.initials: CA
authors.lastname: Sabin
authors.forename: Z
authors.initials: Z
authors.lastname: Kinson
authors.forename: D
authors.initials: D
authors.lastname: Brown
authors.forename: A
authors.initials: A
authors.lastname: Griffioen
authors.forename: G M
authors.initials: GM
authors.lastname: Dusheiko
authors.forename: C A
authors.initials: CA
authors.lastname: Lee
mesh_terms: D018450:Disease Progression; D018067:Flaviviridae / Q000276:immunology / Q000302:isolation & purification; D015658:HIV Infections / Q000150:complications* / Q000276:immunology; D015497:HIV-1; D006467:Hemophilia A / Q000150:complications*; D006508:Hepatitis Antibodies / Q000097:blood; D006525:Hepatitis, Viral, Human / Q000150:complications* / Q000276:immunology / Q000821:virology; D006801:Humans; D012367:RNA, Viral / Q000097:blood; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014759:Viral Envelope Proteins / Q000276:immunology
chemical_list: D006508:Hepatitis Antibodies; D012367:RNA, Viral; D014759:Viral Envelope Proteins; C107619:glycoprotein E2, GB virus C