title: Prevention of nickel-induced allergic contact reactions with pentoxifylline.
abstract: In this study, we investigated the effect of pentoxifylline, an inhibitor of TNF-alpha, on the contact sensitivity response induced by nickel. For induction, open epicutaneous sensitization by NiSO4. 6 H2O (25% aq.) solution was applied on the backs of 38 albino guinea pigs 5 days a week for 4 weeks. NaCl (0.9%) solution was applied epicutaneously to 10 albino guinea pigs as a control group. 19 were sensitized by nickel and developed positive patch test reactions. Patch tests were repeated after 10 of the sensitized pigs were given pentoxifylline 20 mg/kg/day orally. At the end of this study, only 2 positive patch test reactions were observed in the pentoxifylline-treated group, while 7/9 of the untreated guinea pigs developed positive reactions. These results suggest that pentoxifylline inhibits the contact sensitivity response induced by nickel only during drug administration.
authors.affiliation: Department of Dermatology, University of Uludağ, Faculty of Medicine, Bursa, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Saricaoğlu
authors.forename: S
authors.initials: S
authors.lastname: Tunali
authors.forename: E
authors.initials: E
authors.lastname: Bülbül
authors.forename: I R
authors.initials: IR
authors.lastname: White
authors.forename: Z
authors.initials: Z
authors.lastname: Palali
mesh_terms: D000284:Administration, Oral; D000818:Animals; D017449:Dermatitis, Allergic Contact / Q000209:etiology* / Q000517:prevention & control*; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D006168:Guinea Pigs; D007509:Irritants / Q000009:adverse effects*; D009532:Nickel / Q000009:adverse effects*; D010328:Patch Tests; D010431:Pentoxifylline / Q000627:therapeutic use*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D007509:Irritants; D014409:Tumor Necrosis Factor-alpha; C029938:nickel sulfate; D009532:Nickel; D010431:Pentoxifylline