[Diffusion tensor analysis with nuclear magnetic resonance in human central nervous system].
Nuclear magnetic resonance has been used to measure the diffusivity of water molecules. In central nervous system, anisotropic diffusion, which is characterized by apparent diffusion tensor Dapp zeta, is thought to be related to neuronal fiber tract orientation. For precise observation of anisotropic diffusion, it is needed to determine the diagonal and off-diagonal elements of Dapp zeta. Once Dapp zeta is estimated from a series of diffusion weighted images, a tissue's orthotropic principal axes and diffusivity of each direction are determined from eigenvalues and eigenvectors of Dapp zeta. There are several methods to represent anisotropic diffusion with Dapp zeta. Examples are diffusion ellipsoids constructed in each voxel depicting both these principal axes and the mean diffusion length in these directions, trace invariant values and its mapping image, largest eigenvalue, and ratio of largest eigenvalue to the other eigenvalue. In this study, the author investigated practical procedure to analyze diffusion tensor Dapp zeta using both of spin-echo and echo-planer diffusion weighted imagings with 3-tesla magnetic resonance machine in human brain. The ellipsoid representation provided particularly useful information about microanatomy including neuronal fiber tract orientation and molecular mobility reflective of microstructure. Furthermore, in the lesion of Wallerian degeneration, the loss of anisotropy of local apparent diffusion was observed. It is suggested that the function of axons can be observed via degree of anisotropy of apparent diffusion. Consequently, diffusion tensor analysis is expected to be a powerful, noninvasive method capable of quantitative and functional evaluation of the central nervous system.
Nakayama
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Department of Neurosurgery, Hokkaido University School of Medicine, Sapporo, Japan.
D000328:Adult; D000368:Aged; D001369:Axons / Q000502:physiology; D001921:Brain / Q000502:physiology*; D004058:Diffusion; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008875:Middle Aged