Strong increase of 9-hydroxy-10,12-octadecadienoic acid in low density lipoprotein after a hemorrhagic shock.
9-hydroxy-10,12-octadecadienoic acid (9-HODE) is generated by lipid peroxidation (LPO) processes in comparison to other marker compounds in at least 10 fold amount. A 10-25 fold increase of this new marker compound in relation to age matched healthy individuals was observed in the low density lipoprotein (LDL) fraction of ten patients suffering from a hemorrhagic shock. The 9-HODE values dropped to normal levels after recovery. Similarly the 9-HODE content in LDL of patients which had to undergo orthopedic surgery--replacement of their arthritic hip joints by endoprosthesis--were investigated. The rather high HODE values dropped also after recovery reflecting obviously the disappearance of inflammatory processes associated with arthritis.
Kreil
P
P
Lehrstuhl Organische Chemie I, Universität Bayreuth.
Spiteller
G
G
Johannes
G
G
Wagner
W
W
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D008041:Linoleic Acids / Q000097:blood*; D044243:Linoleic Acids, Conjugated; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D012016:Reference Values; D012771:Shock, Hemorrhagic / Q000097:blood*; D013997:Time Factors
D015415:Biomarkers; D008041:Linoleic Acids; D044243:Linoleic Acids, Conjugated; D008077:Lipoproteins, LDL; C024347:9-hydroxy-10,12-octadecadienoic acid