title: Neuropsychiatric systemic lupus erythematosus and the syndrome of inappropriate secretion of antidiuretic hormone: a case report with very late onset systemic lupus erythematosus.
abstract: The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with neuropsychiatric lupus (NP-SLE) is rare. We report a case of SIADH associated with the new onset of SLE in an 88-yr-old female. The unique features of this case include the extreme age of onset of SLE presenting with neuropsychiatric manifestations and positive antiribosomal P antibody titres. Both the NP manifestations of SLE and SIADH were highly correlated with the SLE disease activity. This case illustrates a novel presentation of NP-SLE with SIADH which may develop due to antibody-mediated hypothalamic dysfunction.
authors.affiliation: Department of Internal Medicine, University of Manitoba Health Sciences Centre, Winnipeg, Canada.
authors.forename: S M
authors.initials: SM
authors.lastname: Mirsattari
authors.forename: C
authors.initials: C
authors.lastname: Power
authors.forename: A
authors.initials: A
authors.lastname: Fine
authors.forename: G S
authors.initials: GS
authors.lastname: McGinn
authors.forename: S
authors.initials: S
authors.lastname: Ludwick
authors.forename: J M
authors.initials: JM
authors.lastname: Canvin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000450:Aldosterone / Q000097:blood; D000974:Antibodies, Antinuclear / Q000097:blood; D001921:Brain / Q000473:pathology; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D003866:Depressive Disorder / Q000097:blood / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000097:blood; D007177:Inappropriate ADH Syndrome / Q000097:blood / Q000150:complications* / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000150:complications* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D015800:Protozoan Proteins; D012083:Renin / Q000097:blood; D012269:Ribosomal Proteins / Q000276:immunology; D014667:Vasopressins / Q000097:blood
chemical_list: D000974:Antibodies, Antinuclear; D003176:Complement C3; D003181:Complement C4; C064601:L12E protein, Trypanosoma cruzi; D015800:Protozoan Proteins; D012269:Ribosomal Proteins; D014667:Vasopressins; D000450:Aldosterone; D012083:Renin