Neutrophil-Kupffer-cell interaction in host defenses to systemic infections.
Most relevant textbooks characterize phagocytosis by Kupffer cells as the principal mechanism for clearing bacterial pathogens from the bloodstream and eliminating them from the liver. Here, Stephen Gregory and Edward Wing discuss recent evidence indicating that the actual mechanism is far more complicated, dependent upon the complex interaction of Kupffer cells with neutrophils that immigrate into the liver following infection.
Gregory
S H
SH
Dept of Medicine, University of Pittsburgh School of Medicine, PA 15213-2582, USA. Gregory@med1.dept-med.pitt.edu
Wing
E J
EJ
D000818:Animals; D016470:Bacteremia / Q000276:immunology*; D002450:Cell Communication / Q000276:immunology; D004195:Disease Models, Animal; D007113:Immunity, Innate / Q000502:physiology; D007728:Kupffer Cells / Q000276:immunology*; D008089:Listeria monocytogenes / Q000276:immunology; D008088:Listeriosis / Q000276:immunology; D008099:Liver / Q000276:immunology* / Q000382:microbiology; D051379:Mice; D018448:Models, Immunological; D009504:Neutrophils / Q000276:immunology*