Peliosis of the spleen: an immune-complex disease?
OBJECTIVE
To determine the pathogenesis of splenic peliosis by further morphological and immunohistochemical examination.


RESULTS
Histological, electron microscopic and immunohistochemical examination revealed evidence for an inflammatory genesis of splenic peliosis with destruction of reticular fibres and local deposits of IgG and activated complement C3.


CONCLUSIONS
Our findings indicate that the peliotic lesion in the spleen may be mediated by immune-complex deposits.
Gugger
M
M
Institute of Pathology, Kantonsspital Luzern, Switzerland.
Gebbers
J O
JO
D005260:Female; D006470:Hemorrhage / Q000276:immunology*; D006651:Histocytochemistry; D006801:Humans; D007105:Immune Complex Diseases / Q000150:complications*; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D008875:Middle Aged; D012155:Reticulin / Q000032:analysis; D013154:Spleen / Q000737:chemistry / Q000473:pathology / Q000648:ultrastructure; D013158:Splenic Diseases / Q000276:immunology*
D012155:Reticulin