title: Stress reaction to intense sound exposure under different arousal levels in guinea pigs.
abstract: The general impact of high intensity sound exposure on 25 guinea pigs was investigated at three different levels of arousal: 10 during general anaesthesia. 10 during partial arousal, and 5 during complete arousal. Parameters recorded before and during noise exposure were mean arterial blood pressure, pulse rate, and plasma norepinephrine levels. The anaesthetized group showed no increase in the three parameters during sound exposure. Under partial arousal, pulse rate and norepinephrine level increased significantly: pulse rate from 224.5 beats/min before exposure to 278.6 beats/min during exposure, and norepinephrine level from 558 pg/ml before sound exposure to 1276 pg/ml during exposure. At the time of the complete arousal state norepinephrine and pulse rates increased significantly during noise exposure, while blood pressure showed no additional increase as a result of sound exposure.
authors.affiliation: Department of Communication Disorders, Speech, Language and Hearing, Chaim Sheba Medical Center, Tel Hashomer, Israel. muchnik@ccsg.tau.ac.il
authors.forename: C
authors.initials: C
authors.lastname: Muchnik
authors.forename: T
authors.initials: T
authors.lastname: Rosenthal
authors.forename: E
authors.initials: E
authors.lastname: Peleg
authors.forename: M
authors.initials: M
authors.lastname: Hildesheimer
mesh_terms: D000161:Acoustic Stimulation / Q000295:instrumentation / Q000379:methods; D000704:Analysis of Variance; D000768:Anesthesia, General; D000818:Animals; D001143:Arousal / Q000502:physiology*; D001794:Blood Pressure; D006168:Guinea Pigs; D007103:Immobilization / Q000502:physiology; D009638:Norepinephrine / Q000097:blood; D011674:Pulse; D013016:Sound / Q000009:adverse effects*; D013312:Stress, Physiological / Q000097:blood / Q000209:etiology* / Q000503:physiopathology
chemical_list: D009638:Norepinephrine