Absence of antinociceptive tolerance to improgan, a cimetidine analog, in rats.
Improgan, an analog of the histamine receptor antagonist cimetidine, produces highly effective analgesia following intraventricular injection. The present study examined changes in the antinociceptive effects of improgan following once daily intraventricular injections. Improgan (100-150 microg) produced near maximal antinociception 10 and 30 min after daily administration on all 4 test days, whereas comparable morphine treatments (50 microg) induced considerable tolerance. Thus, improgan produced highly effective analgesia without the development of tolerance.
Bannoura
M D
MD
Department of Pharmacology and Neuroscience, Albany Medical College, Albany, NY, USA.mbannoura@ccgateway.amc.edu
Nalwalk
J W
JW
Tang
Y
Y
Carlile
M
M
Leurs
R
R
Menge
W M
WM
Timmerman
H
H
Hough
L B
LB
D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D002927:Cimetidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004361:Drug Tolerance; D007276:Injections, Intraventricular; D008297:Male; D010147:Pain Measurement; D051381:Rats; D017207:Rats, Sprague-Dawley
D018712:Analgesics, Non-Narcotic; C099531:SKF 92374; D002927:Cimetidine