title: Gastric dysrhythmia in uremic patients on maintenance hemodialysis.
abstract: BACKGROUND
  Dyspeptic symptoms are common in uremic patients receiving hemodialysis. Investigators have placed emphasis on the changes in histopathology and physiology of the gastrointestinal tract. But not much data about the gastric myoelectric activity are available. The aim of this study was to assess gastric myoelectric activity in uremic patients undergoing hemodialysis.
  
  
  METHODS
  Fifty-eight subjects were enrolled. They were assigned to: group I, uremic patients undergoing hemodialysis with dyspeptic complaints (n = 20); group II, non-uremic patients with matched dyspeptic complaints (n = 20); and group III, healthy volunteers without dyspeptic complaints (n = 18). Gastric myoelectric activity was measured with abdominal surface electrodes in each person. Patients in group I were measured twice, before (group Ia) and after (group Ib) hemodialysis. The data were compared between the groups.
  
  
  RESULTS
  In the prehemodialysis period there was a significantly lower percentage of normal slow-wave frequency when compared with group III (fasting, 66.54%+/-5.39% versus 84.58%+/-3.63%; P < 0.005; fed, 72.25%+/-4.16% versus 89.06%+/-2.57%; P < 0.01). In the post-hemodialysis period the difference was even more profound (fasting, 46.52%+/-4.26% versus 84.58%+/-3.63%; P < 0.001; fed, 51.49%+/-6.89% versus 89.06%+/-2.57%; P < 0.005). Yet, when compared with group II, a significant difference existed only in the post-hemodialysis period (fasting, 46.52%+/-4.26% versus 67.30%+/-3.46%; P<0.001; fed, 51.49%+/-6.89% versus 70.41%+/-4.39%; P < 0.01). Another finding is that hemodialysis decreased the gastric myoelectric activity after hemodialysis (fasting, 66.54%+/-5.39% versus 46.52%+/-4.26%; P < 0.001; fed, 72.25%+/-4.16% versus 51.49%+/-6.89%; P < 0.005).
  
  
  CONCLUSIONS
  Uremic patients undergoing hemodialysis have impaired gastric myoelectric activity. Interestingly, hemodialysis seems to cause deterioration in gastric myoelectric activity.
authors.affiliation: Dept. of Internal Medicine, Taichung Veterans General Hospital, Taiwan.
authors.forename: C W
authors.initials: CW
authors.lastname: Ko
authors.forename: C S
authors.initials: CS
authors.lastname: Chang
authors.forename: H C
authors.initials: HC
authors.lastname: Lien
authors.forename: M J
authors.initials: MJ
authors.lastname: Wu
authors.forename: G H
authors.initials: GH
authors.lastname: Chen
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004415:Dyspepsia / Q000503:physiopathology*; D004568:Electrodiagnosis; D005260:Female; D005769:Gastrointestinal Motility / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D013270:Stomach / Q000503:physiopathology*; D014511:Uremia / Q000503:physiopathology* / Q000628:therapy*