[Gas exchange as a factor of the body radiation resistance].
Cold-provoked intensification of oxygen consumption was correlated with individual radioresistance of mice. There was a positive correlation between the parameters in normoxia and hyperoxia, and a distinct negative correlation in hypoxia. Radiosensitizer of hypoxic cells, metronidasol, severed the correlation no matter what level of oxygenation in the course of irradiation. The hypothesis for intracellular pO2 as a mediator of the dependence of individual radioresistance on the gas exchange reactivity has been put forward.
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D000818:Animals; D001784:Blood Gas Analysis; D001835:Body Weight / Q000187:drug effects / Q000528:radiation effects; D002560:Cerebrovascular Circulation / Q000187:drug effects* / Q000528:radiation effects*; D000860:Hypoxia / Q000097:blood*; D008297:Male; D008795:Metronidazole / Q000494:pharmacology*; D051379:Mice; D010101:Oxygen Consumption; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*
D011838:Radiation-Sensitizing Agents; D008795:Metronidazole
Reaktivnost' gazoobmena kak faktor radiorezistentnosti organizma.