Metallothionein isoforms provide neuroprotection against 6-hydroxydopamine-generated hydroxyl radicals and superoxide anions.
Ebadi
M
M
Department of Pharmacology, University of Nebraska College of Medicine, Omaha 68198-6260, USA.
Hiramatsu
M
M
Burke
W J
WJ
Folks
D G
DG
el-Sayed
M A
MA
D000818:Animals; D000838:Anions / Q000494:pharmacology; D001921:Brain / Q000378:metabolism / Q000648:ultrastructure; D002478:Cells, Cultured; D003497:Cyclic N-Oxides / Q000378:metabolism; D004578:Electron Spin Resonance Spectroscopy; D016166:Free Radical Scavengers / Q000494:pharmacology; D017665:Hydroxyl Radical / Q000378:metabolism / Q000494:pharmacology; D008668:Metallothionein / Q000145:classification / Q000494:pharmacology*; D051379:Mice; D008928:Mitochondria / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology; D016627:Oxidopamine / Q000037:antagonists & inhibitors / Q000378:metabolism*; D020033:Protein Isoforms / Q000494:pharmacology*; D013113:Spin Labels; D013481:Superoxides / Q000494:pharmacology*
D000838:Anions; D003497:Cyclic N-Oxides; D016166:Free Radical Scavengers; D018696:Neuroprotective Agents; D020033:Protein Isoforms; D013113:Spin Labels; D013481:Superoxides; D017665:Hydroxyl Radical; C017245:5,5-dimethyl-1-pyrroline-1-oxide; D016627:Oxidopamine; D008668:Metallothionein