title: Mass ingestion of Jimson Weed by eleven teenagers.
abstract: Jimson Weed is a naturally occurring plant which is commonly ingested for its hallucinogenic properties. This paper is a case report summarizing 11 cases of patients, ages 13-21 years, who presented to our emergency department following oral ingestion of large quantities of Jimson Weed pods and seeds. Toxicity following ingestion is due to an atropine-containing alkaloid contained throughout the plant and concentrated in the seeds. Signs and symptoms ranged from asymptomatic mydriasis and tachycardia to severe agitation, disorientation, and hallucinations. Nine of the eleven patients were admitted for observation. There were no deaths associated with these ingestions and none of the patients required physostigmine for reversal of severe anticholinergic symptoms. This paper also includes an historical overview of Jimson Weed, its physiologic effects, the epidemiological data, and a treatment summary.
authors.forename: J
authors.initials: J
authors.lastname: Tiongson
authors.forename: P
authors.initials: P
authors.lastname: Salen
mesh_terms: D000293:Adolescent; D000328:Adult; D018680:Cholinergic Antagonists / Q000506:poisoning*; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D013286:Datura stramonium / Q000506:poisoning*; D005260:Female; D006213:Hallucinogens / Q000506:poisoning*; D006801:Humans; D008297:Male; D010830:Physostigmine / Q000627:therapeutic use; D010939:Plant Poisoning / Q000503:physiopathology / Q000628:therapy; D010946:Plants, Medicinal; D010947:Plants, Toxic
chemical_list: D018680:Cholinergic Antagonists; D002800:Cholinesterase Inhibitors; D006213:Hallucinogens; D010830:Physostigmine