title: Complications in Paget disease at MR imaging.
abstract: OBJECTIVE
  To determine the MR imaging findings in patients with complications of Paget disease of bone.
  
  
  METHODS
  Of 45 patients with Paget disease who underwent MR imaging, 33 (26 men, seven women; age range, 64-91 years) with known complications of the disease were examined. Imaging in this subgroup included radiography (n = 26), computed tomography (n = 12), bone scintigraphy (n = 15), and magnetic resonance (MR) imaging (n = 33). Patients were examined specifically for musculoskeletal and neurologic complications of Paget disease, including fracture, basilar impression, spinal stenosis, bone tumor, and osteoarthrosis.
  
  
  RESULTS
  The 56 complications documented in the 33 patients were fracture (n = 17), neurologic entrapment (n = 19), neoplasm (n = 9), and arthropathy (n = 11). MR imaging was beneficial in the diagnostic evaluation of basilar impression (n = 7), spinal stenosis (n = 12), and the tumor stage (n = 9). It also helped to successfully evaluate pagetic bone narrowing of the coracoacromial arch, which was associated with impingement syndrome and rotator cuff rupture (n = 2). The signal intensities in pagetic bone were most commonly similar to those in fat; this finding had a 100% negative predictive value in excluding neoplasm.
  
  
  CONCLUSIONS
  Although Paget disease is diagnosed economically with conventional radiography, MR imaging is well suited for demonstrating the presence and extent of several characteristic disease complications, including basilar impression, spinal stenosis, and secondary neoplasm.
authors.affiliation: Department of Radiology, University of California, San Diego School of Medicine, USA.
authors.forename: R D
authors.initials: RD
authors.lastname: Boutin
authors.forename: D J
authors.initials: DJ
authors.lastname: Spitz
authors.forename: J S
authors.initials: JS
authors.lastname: Newman
authors.forename: L
authors.initials: L
authors.lastname: Lenchik
authors.forename: L S
authors.initials: LS
authors.lastname: Steinbach
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000209:etiology; D005260:Female; D005598:Fractures, Spontaneous / Q000209:etiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009408:Nerve Compression Syndromes / Q000209:etiology; D010001:Osteitis Deformans / Q000150:complications* / Q000473:pathology*; D010003:Osteoarthritis / Q000209:etiology