Regulation of the sympathetic nerve discharge bursting pattern during heat stress.
Frequency-domain analyses were used to determine the effect of heat stress on the relationships between the discharge bursts of sympathetic nerve pairs and sympathetic and phrenic nerve pairs in chloralose-anesthetized rats. Sympathetic nerve discharge (SND) was recorded from the renal, splanchnic, splenic, and lumbar nerves during increases in core body temperature (Tc) from 38 to 41.4 +/- 0. 3 degreesC. The following observations were made: 1) hyperthermia transformed the cardiac-related bursting pattern of SND to a pattern that contained low-frequency, non-cardiac-related bursts, 2) the pattern transformation was uniform in regionally selective sympathetic nerves, 3) hyperthermia enhanced the frequency-domain coupling between SND and phrenic nerve bursts, and 4) low-frequency SND bursts recorded during hyperthermia contained significantly more activity than cardiac-related bursts. We conclude that acute heat stress profoundly affects the organization of neural circuits responsible for the frequency components in sympathetic nerve activity and that SND pattern transformation provides an important strategy for increasing the level of activity in sympathetic nerves during increased Tc.
Kenney
M J
MJ
Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas 66506, USA.
Claassen
D E
DE
Bishop
M R
MR
Fels
R J
RJ
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003714:Denervation; D004594:Electrophysiology; D005334:Fever / Q000503:physiopathology; D005730:Ganglionic Blockers / Q000494:pharmacology; D006358:Hot Temperature; D007668:Kidney / Q000294:innervation; D008297:Male; D010791:Phrenic Nerve / Q000503:physiopathology; D011311:Pressoreceptors / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013312:Stress, Physiological / Q000503:physiopathology*; D013564:Sympathetic Nervous System / Q000503:physiopathology*
D005730:Ganglionic Blockers