Innovative treatment programs against cancer. I. Ras oncoprotein as a molecular target.
Modulation of Ras function may provide a novel means by which cancer cells with oncogenic mutations can be sensitized to chemotherapeutic or radiotherapeutic regimens. Moreover, cancer cells without ras oncogene mutations can also be eliminated by compounds that interfere with the mevalonate pathway, which is more fundamental to mitogenesis because it allows the synthesis of sterol and nonsterol lipids and without which many Ras-related proteins and nuclear lamins would not be prenylated and functional.
Waddick
K G
KG
Biotherapy and Drug Discovery Programs, Parker Hughes Cancer Center, Hughes Institute, St. Paul, MN 55113, USA.
Uckun
F M
FM
D000818:Animals; D016923:Cell Death; D011905:Genes, ras; D006801:Humans; D008954:Models, Biological; D009154:Mutation; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy*; D015398:Signal Transduction; D018631:ras Proteins / Q000378:metabolism*
D018631:ras Proteins