title: Disease susceptibility and development of the cytokine repertoire in the murine Leishmania major model.
abstract: The murine Leishmania major model has proven fertile ground for the elucidation of CD4+ T cell effector subset differentiation in vivo. The availability of a highly susceptible inbred strain, BALB/c, that develops progressive disease due to the aberrant differentiation of Th2, as opposed to protective Th1, responses, has allowed the identification of both T cell intrinsic as well as T cell extrinsic properties that combine to mediate disease outcome. The intrinsic T cell phenotype relates to the capacity of BALB/c-derived CD4+ T cells to acquire the potential to secrete IL-4 more readily than cells from other strains of mice. The extrinsic T cell phenotype relates to the creation of a T cell repertoire capable of recognizing the immunodominant parasite antigen. Together, the two traits confer the aberrant response seen in susceptible mice challenged with L. major.
authors.affiliation: Department of Medicine, University of California San Francisco, 94143-0654, USA.
authors.forename: D J
authors.initials: DJ
authors.lastname: Fowell
authors.forename: M
authors.initials: M
authors.lastname: Bix
authors.forename: K
authors.initials: K
authors.lastname: Shinkai
authors.forename: D
authors.initials: D
authors.lastname: Lacy
authors.forename: R M
authors.initials: RM
authors.lastname: Locksley
mesh_terms: D000818:Animals; D016207:Cytokines / Q000096:biosynthesis*; D004195:Disease Models, Animal; D004198:Disease Susceptibility / Q000276:immunology; D018320:Leishmania major / Q000276:immunology*; D016773:Leishmaniasis, Cutaneous / Q000235:genetics / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C
chemical_list: D016207:Cytokines