Pre- and post-hatching developmental changes in beta-adrenoceptor subtypes in chick brain.
This study used [3H]CGP 12177 as a radioligand to determine the beta1 and beta2-adrenoceptor changes from the pre-hatching E17 stage, where the beta2 subtype is first detected, to the post-hatching P30 stage. While beta1-adrenoceptors were found to be present from E18 and were limited to cerebellum and hyperstriatum in all stages studied, beta2-adrenoceptors showed a wider distribution throughout the brain. In most of the structures analysed both beta1- and beta2-adrenoceptor binding values reached a maximum in the P2 stage, followed by a decrease over the following days. A second increase in both subtypes was detected again in the P15 and P30 stages. These results support the notion of a specific role for beta-adrenoceptors in neural plasticity in the first week after hatching and suggest that the beta2 subtype is the main adrenoceptor in chick brain throughout its development.
Revilla
R
R
Departamento Biología Celular y Anatomía, Facultad de Biología, Campus de Vegazana s/n, Universidad de León, León 24071, Spain.
Fernández-López
C
C
Revilla
V
V
Fernández-López
A
A
D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D001345:Autoradiography; D001667:Binding, Competitive / Q000502:physiology; D001921:Brain / Q000196:embryology* / Q000254:growth & development*; D001923:Brain Chemistry; D002642:Chick Embryo; D002645:Chickens; D008297:Male; D011412:Propanolamines / Q000494:pharmacology; D011869:Radioligand Assay; D011943:Receptors, Adrenergic, beta / Q000032:analysis*; D014316:Tritium
D000318:Adrenergic beta-Agonists; D011412:Propanolamines; D011943:Receptors, Adrenergic, beta; D014316:Tritium; C033394:CGP 12177