title: [Plasminogen activator inhibitor (PAI-1) and diabetes mellitus. II. PAI-1 in insulin resistant conditions].
abstract: Insulin resistance (IR) is associated with an elevated PAI-1 level and by correlation with insulin and triacylglycerol (TG) levels. While in IR non-diabetics this relationship is close, in patients with NIDDM the mutual relationship is less marked and there are other factors which raise the PAI-1 levels such as proinsulin, oxidation stress or cytokines. Therefore achievement of satisfactory metabolic control, reduction of insulin and TG levels need not be associated with normalization of PAI-1. As it is an independent risk factor of atherosclerosis, further examinations are necessary in order to differentiate in more detail the possible causes of its rising level in order to obtain a rational basis for effective therapy.
authors.affiliation: I. interná klinika MFN, Martin.
authors.forename: P
authors.initials: P
authors.lastname: Galajda
authors.forename: L
authors.initials: L
authors.lastname: Sutarík
authors.forename: L
authors.initials: L
authors.lastname: Vladár
authors.forename: J
authors.initials: J
authors.lastname: Stasko
authors.forename: P
authors.initials: P
authors.lastname: Kubisz
authors.forename: M
authors.initials: M
authors.lastname: Mokán
mesh_terms: D003920:Diabetes Mellitus / Q000097:blood*; D006801:Humans; D007333:Insulin Resistance; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*
chemical_list: D017395:Plasminogen Activator Inhibitor 1
vernacular_title: Inhibítor plazminogénového aktivátora (PAI-1) a diabetes mellitus. II. PAI-1 pri inzulínrezistentných stavoch.