title: Identification of famprofazone ingestion.
abstract: After a traffic accident a 32-year-old man was suspected of having previously taken an illegal drug. An immunochemical screening procedure revealed positive results for amphetamines in both urine and blood samples. The preliminary test was confirmed by GC/MS and both amphetamine and methamphetamine were found in both body fluids. However, the man denied any use of drugs but claimed to have taken four tablets of Gewodin. One of the ingredients, famprofazone, undergoes metabolic conversion to amphetamine and methamphetamine. Using GC/ MS the ingestion of famprofazone was verified by identification of the unchanged parent compound in the urine sample.
authors.affiliation: Institute of Legal Medicine, Friedrich-Wilhelms-University, Bonn, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Musshoff
authors.forename: T
authors.initials: T
authors.lastname: Kraemer
mesh_terms: D000328:Adult; D000661:Amphetamine / Q000378:metabolism / Q000652:urine*; D019969:Amphetamine-Related Disorders / Q000652:urine*; D000700:Analgesics / Q000378:metabolism / Q000652:urine; D018712:Analgesics, Non-Narcotic / Q000378:metabolism / Q000652:urine; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000378:metabolism* / Q000652:urine; D002849:Chromatography, Gas; D004338:Drug Combinations; D005189:False Positive Reactions; D005858:Germany; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000652:urine*; D004366:Nonprescription Drugs; D011720:Pyrazoles / Q000378:metabolism* / Q000652:urine; D047069:Pyrazolones; D015813:Substance Abuse Detection
chemical_list: D000700:Analgesics; D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D004366:Nonprescription Drugs; D011720:Pyrazoles; D047069:Pyrazolones; D008694:Methamphetamine; D000661:Amphetamine; C076013:famprofazone