[Hypoxia and tumors: does HIF-1 transcription factor favor tumor growth or hypoxia?].
HIF-1 is a transcription factor which stimulates the expression of several genes induced by hypoxia, such as the gene encoding the vascular endothelial growth factor VEGF. Three papers report the effects of the inactivation of the HIF-1 alpha gene. The absence of HIF-1 alpha impairs morphogenesis of the vascular tree, both in the embryo and in teratocarcinomas obtained after injection of ES cells. HIF-1 alpha-/-embryos do not survive beyond midgestation. In contrast, one paper reports tumour growth inhibition, and another one its stimulation. These results suggest that the role of HIF-1 in the hypoxic response is dependent on the genetic background.
Vandenbunder
B
B
EP560 CNRS, Institut Pasteur de Lille, Institut de biologie de Lille.
D002455:Cell Division / Q000502:physiology; D015687:Cell Hypoxia / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D005314:Embryonic and Fetal Development; D016228:Endothelial Growth Factors / Q000235:genetics; D005786:Gene Expression Regulation; D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D008222:Lymphokines / Q000235:genetics; D009369:Neoplasms / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology*; D009389:Neovascularization, Pathologic / Q000209:etiology; D009687:Nuclear Proteins / Q000235:genetics / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*; D014407:Tumor Cells, Cultured / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D004268:DNA-Binding Proteins; D016228:Endothelial Growth Factors; D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D008222:Lymphokines; D009687:Nuclear Proteins; D014157:Transcription Factors; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
Hypoxie et tumeurs: le facteur de transcription HIF-1 favorise-t-il la croissance ou l'asphyxie des tumeurs?