title: Accidental subretinal injection of triamcinolone acetonide.
abstract: Approximately one-third of the contents of a 1-ml, 40-mg ampule of triamcinolone acetonide was accidentally injected into the subretinal space of the left eye of a 30-year-old man with chronic uveitis. The manufacturer provided a list of the contents of the ampule. A large, white subretinal mass was seen in the superotemporal quadrant. In subsequent days, the medication was seen to migrate inferiorly. Visual acuity in the left eye was 20/400. Subretinal hemorrhage and mild atrophy of the retinal pigment epithelium and choroid were observed superotemporally. Visual acuity returned to 20/100 (preinjection level) in 1 week. Four months postinjection, the superotemporal atrophy was more severe; the inferotemporal medication was minimally visible without producing significant chorioretinal atrophy. The visual acuity remained at 20/100 until the patient underwent cataract extraction and intraocular lens implantation; his vision then improved to 20/40. Steroids, when not accompanied by harmful vehicle substances, may be well tolerated by ocular tissues.
authors.affiliation: Iran University of Medical Sciences, Rasool Akram Medical Center, Tehran, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Modarres
authors.forename: M M
authors.initials: MM
authors.lastname: Parvaresh
authors.forename: G A
authors.initials: GA
authors.lastname: Peyman
mesh_terms: D000328:Adult; D001284:Atrophy; D002387:Cataract Extraction; D002829:Choroid / Q000187:drug effects* / Q000473:pathology; D002908:Chronic Disease; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007267:Injections; D019654:Lens Implantation, Intraocular; D008297:Male; D010857:Pigment Epithelium of Eye / Q000187:drug effects* / Q000473:pathology; D012166:Retinal Hemorrhage / Q000139:chemically induced* / Q000473:pathology; D014222:Triamcinolone Acetonide / Q000008:administration & dosage / Q000009:adverse effects*; D014605:Uveitis / Q000188:drug therapy; D014792:Visual Acuity
chemical_list: D005938:Glucocorticoids; D014222:Triamcinolone Acetonide