title: The therapeutic potential of oral creatine supplementation in muscle disease.
abstract: The decrease in intracellular creatine concentration observed in a number of muscle diseases may deplete energy homeostasis and may, therefore, be one of the factors determining and/or aggravating muscle weakness and degeneration. Two hypotheses are put forward in the present communication to explain: (i) the mechanisms leading to the disturbances in creatine metabolism found in various muscle diseases; and (ii) the potential of oral creatine supplementation in alleviating the clinical symptoms.
authors.affiliation: Department of Transplant Surgery, University of Innsbruck, Austria. markus.wyss@roche.com
authors.forename: M
authors.initials: M
authors.lastname: Wyss
authors.forename: S
authors.initials: S
authors.lastname: Felber
authors.forename: D
authors.initials: D
authors.lastname: Skladal
authors.forename: A
authors.initials: A
authors.lastname: Koller
authors.forename: C
authors.initials: C
authors.lastname: Kremser
authors.forename: W
authors.initials: W
authors.lastname: Sperl
mesh_terms: D000818:Animals; D003401:Creatine / Q000378:metabolism / Q000627:therapeutic use*; D006801:Humans; D051379:Mice; D018101:Mice, Inbred mdx; D009136:Muscular Dystrophies / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D003401:Creatine