The therapeutic potential of oral creatine supplementation in muscle disease.
The decrease in intracellular creatine concentration observed in a number of muscle diseases may deplete energy homeostasis and may, therefore, be one of the factors determining and/or aggravating muscle weakness and degeneration. Two hypotheses are put forward in the present communication to explain: (i) the mechanisms leading to the disturbances in creatine metabolism found in various muscle diseases; and (ii) the potential of oral creatine supplementation in alleviating the clinical symptoms.
Wyss
M
M
Department of Transplant Surgery, University of Innsbruck, Austria. markus.wyss@roche.com
Felber
S
S
Skladal
D
D
Koller
A
A
Kremser
C
C
Sperl
W
W
D000818:Animals; D003401:Creatine / Q000378:metabolism / Q000627:therapeutic use*; D006801:Humans; D051379:Mice; D018101:Mice, Inbred mdx; D009136:Muscular Dystrophies / Q000188:drug therapy* / Q000378:metabolism
D003401:Creatine