[Dyslipidemia: a predisposing or etiologic factor in atherosclerosis].
Epidemiological and experimental data linking hypercholesterolaemia to atherosclerosis is well established and confirms it has a major risk factor for atherosclerosis. The fact that an increase in blood cholesterol is not necessary or obligatory for atherosclerosis to occur, means that it cannot be considered as a causal factor of the disease. On the other hand, the benefits of treatment of hypercholesterolaemia, even in mildly elevated concentrations, have been demonstrated in many randomised trials of primary and secondary prevention in high risk subjects. Thus, beyond the arguments over cholesterol being a predisposing or causal factor, these universally accepted results have added a new therapeutic arm to the cardiological arsenal.
Emmerich
J
J
Service de médecine vasculaire, hôpital Broussais, Paris.
D000924:Anticholesteremic Agents / Q000627:therapeutic use; D001161:Arteriosclerosis / Q000209:etiology* / Q000517:prevention & control; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications* / Q000188:drug therapy; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors
D000924:Anticholesteremic Agents
Anomalies lipidiques: facteur favorisant ou agent étiologique de l'athérosclérose.