Bystander suppression of experimental autoimmune encephalomyelitis by T cell lines and clones of the Th2 type induced by copolymer 1.
The synthetic amino acid copolymer, copolymer 1 (Cop 1) induces T suppressor (Ts) lines/clones, which are confined to the Th2 pathway, cross react with myelin basic protein (MBP), but not with other myelin antigens on the level of Th2 cytokine secretion. Nevertheless, Cop 1 Ts cells inhibited the IL-2 response of a proteolipid protein (PLP) specific line. Furthermore, Cop 1 Ts cells ameliorated EAE induced by two unrelated encephalitogenic epitopes of PLP: p139-151 and p178-191, that produced different forms of disease. This bystander suppression demonstrated by the Cop 1 Ts cells may explain the therapeutic effect of Cop 1 in EAE and MS.
Aharoni
R
R
Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel.
Teitelbaum
D
D
Sela
M
M
Arnon
R
R
D000818:Animals; D002999:Clone Cells; D003429:Cross Reactions; D016207:Cytokines / Q000276:immunology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000139:chemically induced / Q000276:immunology*; D000939:Epitopes / Q000276:immunology; D005260:Female; D000068717:Glatiramer Acetate; D007166:Immunosuppressive Agents / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009103:Multiple Sclerosis / Q000276:immunology; D004676:Myelin Basic Protein / Q000276:immunology; D018991:Myelin Proteolipid Protein / Q000276:immunology / Q000494:pharmacology; D010446:Peptide Fragments / Q000276:immunology / Q000494:pharmacology; D010455:Peptides / Q000276:immunology*; D018418:Th2 Cells / Q000737:chemistry / Q000166:cytology / Q000276:immunology*
D016207:Cytokines; D000939:Epitopes; D007166:Immunosuppressive Agents; D004676:Myelin Basic Protein; D018991:Myelin Proteolipid Protein; D010446:Peptide Fragments; D010455:Peptides; C435023:myelin proteolipid protein (139-151); C094242:myelin proteolipid protein (178-191); D000068717:Glatiramer Acetate