[The protective effect of the nerve growth factor in exposing a nerve tissue culture to diphtheria toxin].
Diphtheria toxin (1.10(-1)-1.10(-6) Lf/ml) was found to inhibit neurite extension in chick embryo dorsal root ganglia in vitro. If the nerve growth factor (60 ng/ml) was added with toxin in culture media the diphtheria toxin effect was decreased and the neurite outgrowth was compared with control. Protective effect of nerve growth factor by influence of diphtheria toxin may be used in new principles of diphtheria treatment.
Chalisova
N I
NI
Pavlov Institute of Physiology, RAS, St. Petersburg.
Akoev
G N
GN
Penniiaĭnen
V A
VA
D000818:Animals; D002642:Chick Embryo; D046508:Culture Techniques; D004167:Diphtheria Toxin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005727:Ganglia, Spinal / Q000166:cytology / Q000187:drug effects*; D009414:Nerve Growth Factors / Q000494:pharmacology*; D009474:Neurons / Q000166:cytology / Q000187:drug effects
D004167:Diphtheria Toxin; D009414:Nerve Growth Factors
Protektivnyĭ éffekt faktora rosta nervov pri vozdeĭstvii difteriĭnogo toksina na kul'turu nervnoĭ tkani.