title: Follow-up of atypical glandular cells in cervical-endocervical smears.
abstract: Atypical glandular cells of undetermined significance (AGUS) is a diagnostic category of the Bethesda system encompassing glandular-type cells that show either endometrial or endocervical differentiation and display greater atypia than expected for a reactive process but do not meet the criteria for invasive adenocarcinoma. We investigated AGUS in a follow-up study of cervical-endocervical smears with either histology or repeat cytology follow-up. From the cytology files at Northwestern Memorial Hospital over a 4-year period, 136 cervical-endocervical smears were diagnosed with AGUS, which were further subdivided into atypical glandular cells, unqualified (AGC-U); atypical glandular cells, favor reactive (AGC-FR); or atypical glandular cells, favor neoplasia (AGC-FN). Of 96 cases with either histologic or cytologic (cervical-endocervical smear) follow-up, 39 cases of AGC-U had a variety of diagnoses on follow-up, with mostly benign entities in 72% and squamous intraepithelial lesions in 28%. Follow-up of the 36 cases of AGC-FR also demonstrated mostly benign entities (82%) and five cases of squamous intraepithelial lesions. The largest number of premalignant and malignant diagnoses (48%) was found during follow-up of patients with an initial diagnosis of AGC-FN, including the only two cases of adenocarcinoma in situ in our study. In conclusion, our study confirms that AGUS encompasses a wide spectrum of diagnoses, most of which prove to be benign. Subclassification of these cases into "favor reactive" and "favor neoplasia" was found to be helpful in predicting the follow-up status of these patients. However, the small but distinctive percentage of preneoplastic and neoplastic diagnoses seen on follow-up warrant further diagnostic procedures and/or close monitoring in patients with this diagnosis.
authors.affiliation: Departments of Pathology, Cytopathology, and Obstetrics & Gynecology, Northwestern University Medical School, Chicago, IL, USA.
authors.forename: S
authors.initials: S
authors.lastname: Schindler
authors.forename: R J
authors.initials: RJ
authors.lastname: Pooley
authors.forename: D V
authors.initials: DV
authors.lastname: De Frias
authors.forename: G H
authors.initials: GH
authors.lastname: Yu
authors.forename: C W
authors.initials: CW
authors.lastname: Bedrossian
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology; D002584:Cervix Uteri / Q000473:pathology*; D019092:Conization / Q000009:adverse effects*; D004715:Endometriosis / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D004717:Endometrium / Q000473:pathology*; D005088:Exocrine Glands / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006651:Histocytochemistry; D006801:Humans; D007753:Laboratories / Q000592:standards; D011230:Precancerous Conditions / Q000473:pathology; D015203:Reproducibility of Results; D009626:Terminology as Topic; D002577:Uterine Cervical Diseases / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D014626:Vaginal Smears / Q000592:standards