N-Acyl-L-homoserine lactone autoinducers control production of an extracellular lipopeptide biosurfactant required for swarming motility of Serratia liquefaciens MG1.
A nonswarming Serratia liquefaciens mutant deficient in serrawettin W2 production was constructed by transposon mutagenesis. Sequence homology indicated that insertion had occurred in gene swrA, which encodes a putative peptide synthetase. Expression of swrA is controlled by quorum sensing.
Lindum
P W
PW
Department of Microbiology, Technical University of Denmark, 2800 Lyngby, Denmark.
Anthoni
U
U
Christophersen
C
C
Eberl
L
L
Molin
S
S
Givskov
M
M
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000502:physiology; D000595:Amino Acid Sequence; D002465:Cell Movement / Q000235:genetics / Q000502:physiology; D017124:Conserved Sequence; D005110:Extracellular Space / Q000502:physiology; D005798:Genes, Bacterial; D008074:Lipoproteins / Q000096:biosynthesis / Q000737:chemistry / Q000502:physiology*; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010453:Peptide Synthases / Q000235:genetics / Q000502:physiology; D010456:Peptides, Cyclic / Q000096:biosynthesis / Q000737:chemistry / Q000502:physiology*; D017386:Sequence Homology, Amino Acid; D012705:Serratia / Q000235:genetics / Q000502:physiology*; D013501:Surface-Active Agents / Q000737:chemistry / Q000378:metabolism*
D008074:Lipoproteins; C092312:N-butyrylhomoserine lactone; C104908:N-hexanoyl-L-homoserine lactone; D010456:Peptides, Cyclic; D013501:Surface-Active Agents; C073497:serrawettin W2; D010453:Peptide Synthases; D015107:4-Butyrolactone