Partial replacement of dietary casein with soy protein isolate can reduce the severity of retinoid-induced hypertriglyceridemia.
Previous research carried out in an animal model of retinoid-induced hypertriglyceridemia - rats fet a 13-cis retinoic acid (13cRA)-containing diet having casein as the protein source - has demonstrated that the complete replacement of dietary casein with soy protein isolate (SPI) can decrease the severity of this condition. In this study, the effect of partially replacing dietary casein with SPI was investigated. Five groups of male Fischer 344 rats were used in a 14-day study, with two groups being fed diets having casein as the protein source, without or with 13cRA (groups A and B, respectively), and three groups being fed 13cRA-containing diets in which SPI was used to bring about the isonitrogenous replacement of 25, 50, or 100% of the casein in the formula for the diet used for group B (groups C-E, respectively). Serum triglyceride concentration for group B was significantly different (p < 0.05) from that of groups A, D, and E (5.41 vs 2.62, 4.04, and 2.66 mmol/l, respectively). Serum cholesterol concentrations for groups D and E were significantly lower (p < 0.05) than for groups A and B (1.63 and 1.60 vs 2.00 and 2.14 mmol/l, respectively). Thus, the isonitrogenous replacement of 50% of dietary casein with SPI can reduce the severity of retinoid-induced hypertriglyceridemia while decreasing the serum concentration of cholesterol.
Radcliffe
J D
JD
Department of Nutrition and Food Sciences, Texas Woman's University, Houston 77030, USA.
Czajka-Narins
D M
DM
D000818:Animals; D002364:Caseins / Q000008:administration & dosage*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D004044:Dietary Proteins / Q000008:administration & dosage*; D015228:Hypertriglyceridemia / Q000139:chemically induced* / Q000178:diet therapy; D015474:Isotretinoin; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D030262:Soybean Proteins / Q000008:administration & dosage* / Q000627:therapeutic use
D002364:Caseins; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D004044:Dietary Proteins; D030262:Soybean Proteins; D002784:Cholesterol; D015474:Isotretinoin