title: Biosensor development.
abstract: Current biosensor developments can be summarised by different trends. For traditional enzymatic biosensors such as glucose sensors, steady improvements of well known basic principles have been made in order to achieve better sensor stability. On the other hand, new affinity sensors such as nucleic acid sensors, transmembrane sensors, and sensors utilising whole cells or even cell networks have become of increasing interest. New ways to miniaturise biosensors and to control their interfaces down to the molecular level have been introduced (the bioelectronics approach). High-throughput screening based on various signal transduction principles has become of increasing importance.
authors.affiliation: Institute of Physical and Theoretical Chemistry, University of Tübingen, Germany. cz@ipc.uni-tuebingen.de
authors.forename: C
authors.initials: C
authors.lastname: Ziegler
authors.forename: W
authors.initials: W
authors.lastname: Göpel
mesh_terms: D000937:Antigen-Antibody Reactions; D015374:Biosensing Techniques / Q000379:methods* / Q000639:trends; D002845:Chromatography / Q000379:methods; D015342:DNA Probes / Q000737:chemistry; D003920:Diabetes Mellitus / Q000175:diagnosis; D004791:Enzyme Inhibitors / Q000737:chemistry; D005947:Glucose / Q000032:analysis; D008564:Membrane Potentials; D008904:Miniaturization / Q000295:instrumentation; D055095:Optics and Photonics; D020135:Peptide Nucleic Acids / Q000737:chemistry; D015398:Signal Transduction; D013053:Spectrophotometry / Q000379:methods; D014159:Transducers
chemical_list: D015342:DNA Probes; D004791:Enzyme Inhibitors; D020135:Peptide Nucleic Acids; D005947:Glucose