title: Sequence variation of a variable short tandem repeat at the D18S535 locus.
abstract: A short tandem repeat in the D18S535 locus was sequenced in 25 selected alleles. A total of 8 different alleles were found which can be designated according to the total number of repeats. This STR is a simple hypervariable STR consisting of blocks of (GATA) repeats with a basic sequence structure (GATA)1(GACA)1(GATA)1 (GAT)1(GATA)9-16. Population data showed that this is a highly polymorphic STR with a heterozygosity of more than 0.80, a simple structure and small size (130-158 bp) which makes this an interesting DNA polymorphism for forensic and genetic purposes.
authors.affiliation: Institute of Legal Medicine, Faculty of Medicine, Santiago de Compostela, Spain.
authors.forename: M V
authors.initials: MV
authors.lastname: Lareu
authors.forename: S
authors.initials: S
authors.lastname: Barral
authors.forename: A
authors.initials: A
authors.lastname: Salas
authors.forename: A
authors.initials: A
authors.lastname: Carracedo
mesh_terms: D004247:DNA / Q000235:genetics*; D005787:Gene Frequency; D006801:Humans; D011110:Polymorphism, Genetic; D013030:Spain; D020080:Tandem Repeat Sequences; D009626:Terminology as Topic
chemical_list: D004247:DNA