Effects of dantrolene sodium on fibrillation potentials in denervated rat muscles.
To examine whether a decrease in cytosolic Ca2+ affects fibrillation potentials, we studied effects of dantolene on these potentials in denervated rat muscle. Administered intraperitoneally, dantrolene sodium (12-22 mg/kg) abolished fibrillation potentials and subthreshold oscillating potentials over 2.5-6 h without affecting excitability of the muscle to electrical stimulation. Fibrillation potentials reappeared 36-96 h after administration of dantrolene. We suggest that cytosolic Ca2+ has a specific role in generating fibrillations.
Izumi
S I
SI
Department of Rehabilitation Medicine, Keio University School of Medicine, Tokyo, Japan.
Tsubahara
A
A
Chino
N
N
Mineo
K
K
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D003620:Dantrolene / Q000494:pharmacology*; D004558:Electric Stimulation; D004576:Electromyography; D004594:Electrophysiology; D008297:Male; D009121:Muscle Denervation; D009125:Muscle Relaxants, Central / Q000494:pharmacology*; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000294:innervation* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar
D009125:Muscle Relaxants, Central; D003620:Dantrolene