The effects of age on postprandial thermogenesis at four graded energetic challenges: findings in young and older women.
There remains controversy over the effect of age on postprandial thermogenesis, with some studies observing decreased postprandial thermogenesis in older subjects and other studies finding no effect of age. We investigated this issue in 8 young (25.2+/-1.8 years) and 8 older (72.2+/-2.1 years) healthy glucose-tolerant women with normal thyroid hormone status. Repeated measures of the thermic effect of feeding (TEF) were obtained following consumption of test meals containing 0, 1046, 2092, and 4184 kilojoules (kJ) by using indirect calorimetry. TEF at each meal size was determined once in the older subjects and twice in the younger subjects (during follicular and luteal phases of the menstrual cycle) for a total of 96 measurements. There was a positive dose-response between meal size and TEF (p < .001) that was not significantly affected by age group. The best single predictor of TEF expressed as a percentage of meal energy content was waist-to-hip ratio (R2=67.416, p < .02). These results indicate that aging is not associated with decreased TEF in the absence of factors such as a hypothyroid state or glucose intolerance.
Melanson
K J
KJ
The Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.
Saltzman
E
E
Vinken
A G
AG
Russell
R
R
Roberts
S B
SB
D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D001824:Body Constitution; D001833:Body Temperature Regulation / Q000502:physiology*; D004435:Eating / Q000502:physiology*; D002149:Energy Intake; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D005498:Follicular Phase / Q000502:physiology; D006801:Humans; D008183:Luteal Phase / Q000502:physiology