The growth hormone secretagogue KP-102-induced stimulation of food intake is modified by fasting, restraint stress, and somatostatin in rats.
The effects of fasting, restraint stress, and intracerebroventricular (i.c.v.) injection of somatostatin on the growth hormone secretagogue, KP-102-induced stimulation of food intake were examined in rats. KP-102-induced stimulation of food intake was observed in freely-fed rats but not in 24-h starved rats. A 90 min period of restraint stress decreased food intake, and i.c.v. administration of KP-102 counteracted the suppressive effect of restraint on food intake. I.c.v. administration of somatostatin partially attenuated the KP-102-induced stimulation of food intake in freely-fed rats, while somatostatin itself did not change food intake. These results suggest that the stimulatory effect of KP-102 on feeding behavior is evident in freely-fed rats but not in starved rats, and that the effect of KP-102 is counteracted or attenuated by stress or somatostatin.
Shibasaki
T
T
Department of Physiology, Nippon Medical School, Tokyo, Japan.
Yamauchi
N
N
Takeuchi
K
K
Ishii
S
S
Sugihara
H
H
Wakabayashi
I
I
D000818:Animals; D005215:Fasting / Q000502:physiology*; D005247:Feeding Behavior / Q000187:drug effects*; D013006:Growth Hormone / Q000378:metabolism; D007276:Injections, Intraventricular; D008297:Male; D009842:Oligopeptides / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013004:Somatostatin / Q000494:pharmacology*; D013312:Stress, Physiological / Q000503:physiopathology*
D009842:Oligopeptides; D013004:Somatostatin; D013006:Growth Hormone; C091874:growth hormone-releasing peptide-2