title: Antimicrobial activity of the semisynthetic compound, hexahydrocolupulone.
abstract: In this study we demonstrate that hexahydrocolupulone (HHC) more effectively inhibits the growth in vitro of Gram-positive organisms than Mycobacterium tuberculosis or Escherichia coli. Vancomycin-resistant Enterococcus faecium, methicillin-resistant Staphylococcus aureus, and coagulase-negative staphylococci were inhibited by HHC at concentrations < or = 4.06 mg/L. Growth inhibition profiles varied according to the microorganism evaluated (static for S. aureus and bactericidal for Bacillus subtilis).
authors.affiliation: Department of Pharmacology, University of Minnesota Medical School, Minneapolis 55455, USA.
authors.forename: T E
authors.initials: TE
authors.lastname: Stephan
authors.forename: E O
authors.initials: EO
authors.lastname: Ngo
authors.forename: P
authors.initials: P
authors.lastname: Ferrieri
authors.forename: J M
authors.initials: JM
authors.lastname: Besser
authors.forename: L M
authors.initials: LM
authors.lastname: Nutter
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects / Q000302:isolation & purification; D003512:Cyclohexanones / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000302:isolation & purification; D006801:Humans; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000302:isolation & purification; D013211:Staphylococcus aureus / Q000187:drug effects / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D003512:Cyclohexanones; C111226:hexahydrocolupulone