title: Single-photon emission computed tomography image of benzodiazepine receptors in a patient with Creutzfeldt-Jakob disease.
abstract: A 50-year-old woman presented with progressive visual disturbance, ataxia, and dementia. The cerebral cortex became atrophic, as the disease progressed, and electroencephalography showed periodic synchronous discharges. The patient's prion gene revealed a point mutation (232Met to Arg), and a diagnosis of Creutzfeldt-Jakob disease was made. Iomazenil single-photon emission computed tomography (SPECT) was performed to assess neuronal degeneration. Accumulation of the tracer in the late images was severely decreased diffusely spread throughout the cerebral cortex. Our experience with this case suggests that iomazenil SPECT is useful for detecting neuronal degeneration in Creutzfeldt-Jakob disease.
authors.affiliation: Department of Neurology, Keio University School of Medicine, Tokyo.
authors.forename: Y
authors.initials: Y
authors.lastname: Itoh
authors.forename: T
authors.initials: T
authors.lastname: Amano
authors.forename: T
authors.initials: T
authors.lastname: Shimizu
authors.forename: J
authors.initials: J
authors.lastname: Hashimoto
authors.forename: A
authors.initials: A
authors.lastname: Kubo
authors.forename: Y
authors.initials: Y
authors.lastname: Fukuuchi
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging*; D001923:Brain Chemistry; D002524:Cerebellar Ataxia / Q000000981:diagnostic imaging / Q000209:etiology; D007562:Creutzfeldt-Jakob Syndrome / Q000000981:diagnostic imaging* / Q000235:genetics; D005260:Female; D005442:Flumazenil / Q000031:analogs & derivatives; D006801:Humans; D008875:Middle Aged; D009207:Myoclonus / Q000000981:diagnostic imaging / Q000209:etiology; D009410:Nerve Degeneration / Q000000981:diagnostic imaging*; D009419:Nerve Tissue Proteins / Q000032:analysis*; D017354:Point Mutation; D018621:PrPC Proteins / Q000235:genetics; D011963:Receptors, GABA-A / Q000032:analysis*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D009419:Nerve Tissue Proteins; D018621:PrPC Proteins; D011963:Receptors, GABA-A; D005442:Flumazenil; C063038:iomazenil