Tumour suppressor gene mutations in humans and mice: parallels and contrasts.
Tumour suppressor genes prevent cancer development. They can be identified by studying humans, but a full understanding of the mechanisms of their action requires the production of animal models. Mice with mutations in tumour suppressor genes can be produced by gene targeting. The phenotypic consequences of tumour suppressor gene mutations in mice and humans show parallels and contrasts, and both can contribute to the elucidation of disease processes.
Hooper
M L
ML
Sir Alastair Currie Cancer Research Campaign Laboratories, Department of Pathology, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK. m.hooper@ed.ac.uku
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics; D016161:Genes, Retinoblastoma; D016147:Genes, Tumor Suppressor; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics; D051379:Mice; D009154:Mutation; D013577:Syndrome; D014157:Transcription Factors / Q000235:genetics; D025721:WT1 Proteins; D009396:Wilms Tumor / Q000235:genetics
D004268:DNA-Binding Proteins; D014157:Transcription Factors; D025721:WT1 Proteins