title: Solitary rectal ulcer syndrome accompanied by submucosal invasive carcinoma.
abstract: We report a case of carcinoma in solitary rectal ulcer syndrome. The diagnosis was made by colonoscopic appearance and biopsy. A tumor measuring 0.9 x 0.6 cm was found in a resected solitary rectal ulcer. The lesion exhibited typical histological features of solitary rectal ulcer syndrome, with a well differentiated adenocarcinoma invading submucosal layers and some dysplastic glands. We believe that the adenocarcinoma represents a malignant transformation from solitary rectal ulcer syndrome, because similar to longstanding chronic idiopathic colitis, colorectal dysplasia and carcinoma may develop.
authors.affiliation: First Department of Internal Medicine, Nagoya City University Medical School, Nagoya, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Tsuchida
authors.forename: N
authors.initials: N
authors.lastname: Okayama
authors.forename: M
authors.initials: M
authors.lastname: Miyata
authors.forename: T
authors.initials: T
authors.lastname: Joh
authors.forename: Y
authors.initials: Y
authors.lastname: Yokoyama
authors.forename: M
authors.initials: M
authors.lastname: Itoh
authors.forename: K
authors.initials: K
authors.lastname: Kobayashi
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012002:Rectal Diseases / Q000473:pathology*; D012004:Rectal Neoplasms / Q000473:pathology*; D014456:Ulcer / Q000473:pathology*