Endogenous retroviruses and multiple sclerosis. II. HERV-7q.
The search for new endogenous retroviral sequences, on the basis of sequence homologies with the pol gene of the recently reported multiple sclerosis associated retrovirus (MSRV), allowed us to identify a full length endogenous retrovirus sequence located on the long arm of human chromosome 7. This retrovirus, HERV-7q, includes in its env region, within a single 1,620 bp open reading frame, a 664 bp domain almost identical to a 3' non-coding region of the rab7 gene. Transcripts encompassing both the env and the 3' LTR regions of HERV-7q have already been identified as expressed sequence tags, suggesting that this env-like gene might code for a 538 amino acid long deduced protein.
Alliel
P M
PM
Inserm, Paris, France.
Périn
J P
JP
Pierig
R
R
Nussbaum
J L
JL
Ménard
A
A
Rieger
F
F
D000595:Amino Acid Sequence; D001483:Base Sequence; D002897:Chromosomes, Human, Pair 7; D020077:Endogenous Retroviruses / Q000235:genetics*; D015752:Genes, env; D006801:Humans; D008969:Molecular Sequence Data; D009103:Multiple Sclerosis / Q000821:virology*; D016366:Open Reading Frames; D017386:Sequence Homology, Amino Acid