Effects of neocortical ectopias upon the acquisition and retention of a non-spatial reference memory task in BXSB mice.
BXSB mice have a 40-60% incidence of small, focal, neocortical dysplasias called ectopias. Ectopics and non-ectopics were compared on horizontal-vertical discrimination learning, a non-spatial cognitive task. No differences were found during acquisition. Ectopic mice, however, were superior when retested 8 weeks later. The results support prior findings that ectopic mice have better long-term spatial memory and extend this conclusion to the non-spatial domain.
Balogh
S A
SA
Biobehavioral Sciences Graduate Degree Program, University of Connecticut, Storrs, CT 06269-4154, USA.
Sherman
G F
GF
Hyde
L A
LA
Denenberg
V H
VH
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D001927:Brain Diseases / Q000503:physiopathology*; D002828:Choristoma / Q000503:physiopathology*; D004193:Discrimination Learning / Q000502:physiology; D005260:Female; D008297:Male; D018782:Maze Learning / Q000502:physiology; D051379:Mice; D008815:Mice, Inbred Strains; D019579:Neocortex; D017397:Prefrontal Cortex / Q000502:physiology; D012153:Retention, Psychology / Q000502:physiology*