title: Acute allergic reaction and demonstration of specific IgE antibodies against alpha-1-protease inhibitor.
abstract: A 44 yr-old female with severe pulmonary emphysema and reduced alpha-1-protease inhibitor (alpha1-PI) serum levels developed an acute anaphylactic reaction following the third intravenous infusion of human alpha1-PI which was administered to prevent the progression of pulmonary emphysema. Specific immunoglobulin E-antibodies against human alpha1-PI could be demonstrated in the patient's serum using an enzyme allergosorbent test. Because of the risk of further severe anaphylactic reaction, the replacement therapy with alpha1-PI was discontinued. Physicians should be aware of this rare complication.
authors.affiliation: Ruhrlandklinik, Dept of Pneumology, University of Essen, Germany.
authors.forename: F J
authors.initials: FJ
authors.lastname: Meyer
authors.forename: M
authors.initials: M
authors.lastname: Wencker
authors.forename: H
authors.initials: H
authors.lastname: Teschler
authors.forename: H
authors.initials: H
authors.lastname: Steveling
authors.forename: J
authors.initials: J
authors.lastname: Sennekamp
authors.forename: U
authors.initials: U
authors.lastname: Costabel
authors.forename: N
authors.initials: N
authors.lastname: Konietzko
mesh_terms: D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis; D004342:Drug Hypersensitivity / Q000276:immunology*; D004646:Emphysema / Q000188:drug therapy; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology; D007073:Immunoglobulin E / Q000032:analysis*; D007262:Infusions, Intravenous; D011480:Protease Inhibitors / Q000009:adverse effects* / Q000276:immunology* / Q000627:therapeutic use; D000515:alpha 1-Antitrypsin / Q000009:adverse effects* / Q000276:immunology* / Q000627:therapeutic use
chemical_list: D000888:Antibodies, Anti-Idiotypic; D011480:Protease Inhibitors; D000515:alpha 1-Antitrypsin; D007073:Immunoglobulin E