title: Diffuse neurofibroma of the ankle.
abstract: OBJECTIVE
  To correlate the imaging and histological findings in diffuse neurofibroma.
  
  
  METHODS
  Retrospective review of clinical, imaging and histological findings in two patients with diffuse neurofibroma.
  
  
  RESULTS
  CT demonstrates diffuse infiltration of the deep and subcutaneous fat, isodense to muscle. Magnetic resonance imaging shows extensive infiltration of the subcutaneous and deep fat that envelops tendons and vessels but does not involve bone. Superficial masses enhance homogeneously after intravenous gadolinium. The reticular nature of the deep infiltration is seen on all sequences but is most conspicuous on post-gadolinium T1-weighted images which show tumour enhancement and non-enhancing hypointense soft tissue strands. Magnetic resonance angiography and Doppler ultrasound may show enlarged vessels, high blood flow and vascular pools.
  
  
  CONCLUSIONS
  Diffuse neurofibroma has a characteristic appearance on magnetic resonance that is best shown on post-gadolinium T1-weighted images.
authors.affiliation: Department of Clinical Radiology, Royal Infirmary of Edinburgh, UK.
authors.forename: I
authors.initials: I
authors.lastname: Beggs
authors.forename: H M
authors.initials: HM
authors.lastname: Gilmour
authors.forename: R M
authors.initials: RM
authors.lastname: Davie
mesh_terms: D000293:Adolescent; D000328:Adult; D000842:Ankle; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009455:Neurofibroma / Q000175:diagnosis*; D012189:Retrospective Studies; D012983:Soft Tissue Neoplasms / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed; D018608:Ultrasonography, Doppler