[Deep venous thrombosis in pregnant women].
The main risk factors for deep vein thrombosis in pregnancy and after delivery are preeclampsia, operative delivery, adiposity, prolonged bed rest, and haemostatic defects (antithrombin, protein C and protein S deficiencies), activated protein C resistance, lupus anticoagulant/antiphospholipid antibodies. Hyperhomocystinaemia is a general risk factor for deep vein thrombosis. The clinical diagnosis of deep vein thrombosis is difficult and must be confirmed by imaging techniques. Positive D-dimer has high sensitivity, but low specificity to detect acute thrombosis. Standard treatment is unfractionated heparin intravenously for 7-10 days, followed by subcutaneous injections. Anticoagulant treatment is prolonged for 6-12 weeks after delivery, usually with warfarin. During pregnancies associated with high risk of thrombosis, low molecular heparin prophylaxis is given during pregnancy and 6-12 weeks after delivery. Thrombosis in pregnancy must be followed by adequate investigation for an underlying thrombotic predisposition.
Hervig
T
T
Blodbanken, Haukeland Sykehus, Bergen.
Haram
K
K
Sandset
P M
PM
D004198:Disease Susceptibility; D005260:Female; D017408:Guidelines as Topic; D006801:Humans; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000175:diagnosis* / Q000188:drug therapy / Q000517:prevention & control; D011655:Pulmonary Embolism / Q000175:diagnosis / Q000188:drug therapy / Q000517:prevention & control; D013923:Thromboembolism / Q000175:diagnosis / Q000188:drug therapy / Q000517:prevention & control; D020246:Venous Thrombosis / Q000175:diagnosis* / Q000188:drug therapy / Q000517:prevention & control
Dyp venetrombose hos gravide.