Memory mechanisms: the nociceptin connection.
A link between long-term potentiation (LTP) and memory has been supported by learning defects following treatments that impair LTP. Important new evidence for the link comes from mutant mice lacking the nociceptin receptor, which show improved learning and memory accompanied by enhanced LTP.
Goda
Y
Y
Department of Biology University of California, San Diego 9500 Gilman Drive La Jolla California 92093-0366 USA.
Mutneja
M
M
D000818:Animals; D007858:Learning / Q000502:physiology; D017774:Long-Term Potentiation / Q000502:physiology; D008568:Memory / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D008959:Models, Neurological; D018847:Opioid Peptides / Q000502:physiology*; D011957:Receptors, Opioid / Q000235:genetics / Q000502:physiology; D000094942:Nociceptin Receptor; D000097629:Nociceptin
D018847:Opioid Peptides; D011957:Receptors, Opioid; D000094942:Nociceptin Receptor; D000097629:Nociceptin; C000722287:Oprl1 protein, mouse