Spectrofluorimetric determination of tacrine in pharmaceuticals and spiked human serum.
A spectrofluorimetric method to determine tacrine is proposed and applied to the determination of tacrine in human serum and pharmaceuticals. The fluorimetric method allows the determination of 1-70 ng ml-1 of tacrine in aqueous solutions containing acetic acid-sodium acetate buffer (pH 5.6) with lambda exc = 242 nm and lambda em = 362 nm.
Aparico
I
I
Department of Analytical Chemistry, Faculty of Chemistry, Seville, Spain.
Bello
M A
MA
Callejón
M
M
Jiménez
J C
JC
Guiraúm
A
A
D002800:Cholinesterase Inhibitors / Q000032:analysis* / Q000097:blood; D006801:Humans; D013050:Spectrometry, Fluorescence; D013619:Tacrine / Q000032:analysis* / Q000097:blood
D002800:Cholinesterase Inhibitors; D013619:Tacrine