[Cyclic GMP mimicks potentiation effect of the nootropic agent vinpocetine on the high threshold A-current in the mollusk neurons].
High-threshold transient K+ current (IAht) was recorded using a two-microelectrode voltage clamp technique in isolated neurons of the land snail. Effect of the nootropic drug vinpocetine on this current was studied and compared with cyclic nucleotides. The drug either enhanced or left unaltered the IAht, and dibutyryl cyclic GMP (dcGMP) imitated the effect. These two effects were not additive. Dibutyryl cyclic AMP did not imitate, the vinpocetine effect and decreased the amplitude of the IAht. The findings suggest that the cGMP mediated the vinpocetine effect on the Iaht.
Solntseva
E I
EI
Institute of Brain Research, Moscow, Russia.
Bukanova
Iu V
IuV
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D006152:Cyclic GMP / Q000502:physiology*; D003995:Dibutyryl Cyclic GMP / Q000494:pharmacology; D006372:Helix, Snails; D066298:In Vitro Techniques; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D018697:Nootropic Agents / Q000494:pharmacology*; D018408:Patch-Clamp Techniques; D015221:Potassium Channels / Q000187:drug effects*; D014748:Vinca Alkaloids / Q000494:pharmacology*
D018697:Nootropic Agents; D015221:Potassium Channels; D014748:Vinca Alkaloids; D003995:Dibutyryl Cyclic GMP; C013983:vinpocetine; D003994:Bucladesine; D006152:Cyclic GMP
Tsiklicheskiĭ GMF imitiruet potentsiruiushchiĭ éffekt nootropa vinpotsetina na vysokoporogovyĭ A-tok neĭronov molluska.