title: dRGS7 encodes a Drosophila homolog of EGL-10 and vertebrate RGS7.
abstract: We identified a Drosophila gene encoding a homolog of the regulator of G-protein signaling (RGS) protein family. This gene (dRGS7) is expressed in neurons of the embryo and adult fly and is predicted to encode a 428-amino acid protein with >55% overall amino acid sequence identity with the vertebrate protein RGS7 and the C. elegans EGL-10. The dRGS7 protein is 50% conserved in the C-terminal RGS domain with RGS7 and EGL-10 but, remarkably, displays much greater conservation with the N-terminal regions of these proteins. This finding implies a conserved function for these homologs from divergent species involving domains outside the RGS domain. The dRGS7 protein also has a domain of similarity with Dishevelled and pleckstrin, raising the possibility that these proteins interact with common signaling components.
authors.affiliation: Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas 75235-9111, USA.
authors.forename: T
authors.initials: T
authors.lastname: Elmore
authors.forename: A
authors.initials: A
authors.lastname: Rodriguez
authors.forename: D P
authors.initials: DP
authors.lastname: Smith
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D029742:Caenorhabditis elegans Proteins; D018076:DNA, Complementary; D004330:Drosophila / Q000196:embryology / Q000235:genetics*; D029721:Drosophila Proteins; D020555:GTP-Binding Protein Regulators; D019204:GTP-Binding Proteins; D017344:Genes, Insect; D006801:Humans; D008969:Molecular Sequence Data; D009474:Neurons / Q000378:metabolism; D016133:Polymerase Chain Reaction; D011506:Proteins / Q000737:chemistry* / Q000235:genetics*; D020710:RGS Proteins; D012333:RNA, Messenger / Q000378:metabolism; D017386:Sequence Homology, Amino Acid
chemical_list: D029742:Caenorhabditis elegans Proteins; D018076:DNA, Complementary; D029721:Drosophila Proteins; C105577:EGL-10 protein, C elegans; D020555:GTP-Binding Protein Regulators; D011506:Proteins; D020710:RGS Proteins; C492039:RGS7 protein, human; D012333:RNA, Messenger; C115770:RSG7 protein, Drosophila; D019204:GTP-Binding Proteins