title: Biocompatibility of cellulose sponge with bone.
abstract: The purpose of this study was to investigate the biocompatibility of viscose cellulose sponge (VCS) with bone. Twenty-five Sprague-Dawley rats were used for the study. After curettage of the bone marrow from both femoral cavities, VCS (15 x 1 x 1 mm) was implanted into one femur, leaving the contralateral side empty as a control. The rats were killed 1-6 weeks after curettage, and bone formation inside the sponge was assessed by light-microscopic examination and histomorphometric assessment. Whereas normal bone formation in rat femoral cavity took place in 2 weeks after curettage, 4 weeks were needed for bone formation in the cellulose sponge. VCS is a compatible matrix for osseous tissue ingrowth and it may be useful as a scaffold for bone tissue engineering in experiments and possibly also in clinical practice.
authors.affiliation: Department of Paediatric Surgery, University of Turku, Finland. matmar@utu.fi
authors.forename: M
authors.initials: M
authors.lastname: Märtson
authors.forename: J
authors.initials: J
authors.lastname: Viljanto
authors.forename: T
authors.initials: T
authors.lastname: Hurme
authors.forename: P
authors.initials: P
authors.lastname: Saukko
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001842:Bone and Bones / Q000601:surgery*; D002482:Cellulose; D008297:Male; D008422:Materials Testing; D016348:Osseointegration; D010012:Osteogenesis; D019736:Prostheses and Implants; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D001672:Biocompatible Materials; D002482:Cellulose