T cell adhesion to the extracellular matrix proteins as a determinant of pregnancy success or failure.
Recent studies emphasize an important role of the extracellular matrix (ECM) proteins in the regulation of T cell function. The role of the T cell:ECM interaction during pregnancy has not been established yet. ECM proteins promote acquisition of the adhesive and degradive properties required by the embryo for successful implantation. T cells presented at the maternal-foetal interface may regulate the maternal immune response to the foetal allograft. T cell adhesion to collagen IV (C-IV), elastin (E) and fibronectin in 35 women with threatened abortion and in five normal pregnant women were studied. The relationship between T cell adhesion to ECM and pregnancy outcome was analyzed. Correlation between T cell adhesion to fibronectin and C-IV and pregnancy success or failure were observed. Our studies indicate that there is enhanced T cell adhesion to C-IV and fibronectin in women with unexplained threatened abortion, especially in those with a previous history of recurrent spontaneous abortion (RSA).
Małgorzata
J
J
Department of Clinical Immunology, University School of Medicine, Lublin, Poland. Jerzak@Asklepios.am.lublin.pl
Górski
A
A
D000033:Abortion, Threatened / Q000503:physiopathology*; D000328:Adult; D002448:Cell Adhesion; D003094:Collagen / Q000502:physiology; D016326:Extracellular Matrix Proteins / Q000502:physiology*; D005260:Female; D005353:Fibronectins / Q000502:physiology; D005865:Gestational Age; D006388:Hemagglutinins / Q000494:pharmacology; D006801:Humans; D008213:Lymphocyte Activation; D011247:Pregnancy; D011256:Pregnancy Outcome; D012008:Recurrence; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D016326:Extracellular Matrix Proteins; D005353:Fibronectins; D006388:Hemagglutinins; D003094:Collagen; D013755:Tetradecanoylphorbol Acetate