Cell-cell interaction and tissue factor expression.
Following tissue injury, blood components come into contact with the subendothelial tissue, a thrombogenic surface. Tissue factor, found in the media and adventitia of the vascular wall, or available on the membrane of activated monocytes and endothelial cells, triggers blood coagulation. A complex interaction between soluble molecules and cells then takes place, a fibrin mesh is formed, and the resulting clot limits or stops the loss of blood. Platelets, monocytes, and endothelial cells co-localize and interact in the area of vascular injury. This close relationship, which is regulated by an array of cell-cell adhesion molecules, favours the modulation of the biochemical pathways of these cells. The aim of this review is to summarize the contribution of these cells and their interactions in tissue factor expression and its possible relevance in the pathogenesis of vascular diseases.
Lorenzet
R
R
Department of Vascular Medicine and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy. lorenzet@cmns.mnegri.it
Napoleone
E
E
Celi
A
A
Pellegrini
G
G
Di Santo
A
A
D001792:Blood Platelets / Q000166:cytology / Q000378:metabolism; D002450:Cell Communication / Q000502:physiology*; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D009000:Monocytes / Q000166:cytology / Q000378:metabolism; D013925:Thromboplastin / Q000096:biosynthesis* / Q000502:physiology
D013925:Thromboplastin