title: Biodegradable controlled release glass in the repair of peripheral nerve injuries.
abstract: The experiments in this paper were concerned with the recovery of function and ease of application of an entubulation technique using a biodegradable, controlled release glass tube (CRG) for the repair of a transected peripheral nerve. The peroneal nerves of 15 New Zealand White rabbits were repaired with either a CRG tube filled with freeze-thawed muscle, or a conventional freeze thawed muscle graft (FTMG). These were compared with controls in which a CRG was used to enclose the cut ends of a nerve separated by a 1 cm gap. Electrophysiological and morphometric assessment was carried out 6 months after repair. No statistical difference was found in any test between the FTMG and the CRG tube filled with freeze thawed muscle. The CRG tube and 1 cm gap produced inferior levels of recovery of function when compared with the other two repair groups.
authors.affiliation: Department of Clinical Neuroscience, University of Edinburgh, Ayr, UK.
authors.forename: D V
authors.initials: DV
authors.lastname: Lenihan
authors.forename: A J
authors.initials: AJ
authors.lastname: Carter
authors.forename: T
authors.initials: T
authors.lastname: Gilchrist
authors.forename: D M
authors.initials: DM
authors.lastname: Healy
authors.forename: I A
authors.initials: IA
authors.lastname: Miller
authors.forename: L M
authors.initials: LM
authors.lastname: Myles
authors.forename: M A
authors.initials: MA
authors.lastname: Glasby
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001369:Axons / Q000473:pathology / Q000502:physiology; D001673:Biodegradation, Environmental; D015925:Cryopreservation; D004576:Electromyography; D004867:Equipment Design; D005500:Follow-Up Studies; D005898:Glass / Q000737:chemistry; D007440:Intubation / Q000295:instrumentation*; D009045:Motor Endplate / Q000473:pathology / Q000502:physiology; D009046:Motor Neurons / Q000473:pathology / Q000502:physiology; D018482:Muscle, Skeletal / Q000637:transplantation; D009412:Nerve Fibers / Q000473:pathology / Q000502:physiology; D009416:Nerve Regeneration / Q000502:physiology; D009431:Neural Conduction / Q000502:physiology; D010543:Peroneal Nerve / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D011817:Rabbits; D011930:Reaction Time; D014182:Transplantation, Autologous; D014945:Wound Healing