title: Spectrofluorimetric determination of tacrine in pharmaceuticals and spiked human serum.
abstract: A spectrofluorimetric method to determine tacrine is proposed and applied to the determination of tacrine in human serum and pharmaceuticals. The fluorimetric method allows the determination of 1-70 ng ml-1 of tacrine in aqueous solutions containing acetic acid-sodium acetate buffer (pH 5.6) with lambda exc = 242 nm and lambda em = 362 nm.
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, Seville, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Aparico
authors.forename: M A
authors.initials: MA
authors.lastname: Bello
authors.forename: M
authors.initials: M
authors.lastname: Callejón
authors.forename: J C
authors.initials: JC
authors.lastname: Jiménez
authors.forename: A
authors.initials: A
authors.lastname: Guiraúm
mesh_terms: D002800:Cholinesterase Inhibitors / Q000032:analysis* / Q000097:blood; D006801:Humans; D013050:Spectrometry, Fluorescence; D013619:Tacrine / Q000032:analysis* / Q000097:blood
chemical_list: D002800:Cholinesterase Inhibitors; D013619:Tacrine