Strobilurin M, tetrachloropyrocatechol and tetrachloropyrocatechol methyl ether: new antibiotics from a Mycena species.
The antifungal and cytostatic compound strobilurin M (1) is a new variant of the strobilurins produced by Mycena sp. 96097, a tropical basidiomycete. The same fungus was found to produce tetrachloropyrocatechol (3a) and tetrachloropyrocatechol methyl ether (3b), new natural products, which exhibit antifungal, antibacterial and cytotoxic activities.
Daferner
M
M
LB Biotechnologie der Universität, Kaiserslautern, FRG.
Anke
T
T
Hellwig
V
V
Steglich
W
W
Sterner
O
O
D000363:Agaricales / Q000737:chemistry / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology; D002396:Catechols / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D004952:Esters / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology*; D005285:Fermentation; D005947:Glucose / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism*; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008689:Methacrylates; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010100:Oxygen / Q000378:metabolism; D010407:Penicillium / Q000187:drug effects / Q000378:metabolism; D000073739:Strobilurins
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D002396:Catechols; D004952:Esters; D005231:Fatty Acids, Unsaturated; D008689:Methacrylates; D000073739:Strobilurins; C115621:fattiviracin A1; C115620:strobilurin M; C115619:tetrachloropyrocatechol; C115618:tetrachloropyrocatechol methyl ester; D005947:Glucose; D010100:Oxygen