title: Vertebrate segmentation: the clock is linked to Notch signalling.
abstract: The periodic formation of somites during vertebrate segmentation has been suggested to involve a molecular 'segmentation clock'. Recent observations of cyclic Lunatic fringe expression in chick and mouse embryos link the segmentation clock to Delta-Notch signalling.
authors.affiliation: Vertebrate Development Laboratory Imperial Cancer Research Fund 44 Lincoln's Inn Fields London WC2A 3PX UK.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Jiang
authors.forename: L
authors.initials: L
authors.lastname: Smithers
authors.forename: J
authors.initials: J
authors.lastname: Lewis
mesh_terms: D000818:Animals; D030161:Avian Proteins; D001683:Biological Clocks; D019521:Body Patterning / Q000235:genetics / Q000502:physiology*; D002642:Chick Embryo; D018507:Gene Expression Regulation, Developmental; D016695:Glycosyltransferases; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology*; D051379:Mice; D011506:Proteins / Q000235:genetics / Q000502:physiology; D051880:Receptors, Notch; D015398:Signal Transduction; D019170:Somites / Q000166:cytology
chemical_list: D030161:Avian Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D011506:Proteins; D051880:Receptors, Notch; C064045:delta protein; D016695:Glycosyltransferases; C498394:LFNG protein, Gallus gallus; C498392:Lfng protein, mouse