title: Microbial dehalogenases: enzymes recruited to convert xenobiotic substrates.
abstract: Microbial dehalogenases are involved in the biodegradation of many important chlorinated pollutants. Some recent studies of haloalkane dehalogenase, dichloromethane dehalogenase, tetrachlorohydroquinone dehalogenase and perchloroethylene and trichloroethylene reductive dehalogenases have addressed the issue of recruitment and adaptation of proteins to dehalogenate novel substrates.
authors.affiliation: University of Colorado at Boulder, Department of Chemistry and Biochemistry 80309, USA. copley@cires.colorado.edu
authors.forename: S D
authors.initials: SD
authors.lastname: Copley
mesh_terms: D001673:Biodegradation, Environmental; D005075:Biological Evolution; D018360:Crystallography, X-Ray; D005982:Glutathione Transferase / Q000737:chemistry; D006088:Gram-Negative Aerobic Bacteria / Q000201:enzymology* / Q000235:genetics; D006867:Hydrolases / Q000737:chemistry* / Q000235:genetics; D006873:Hydroquinones / Q000737:chemistry; D008190:Lyases / Q000737:chemistry / Q000235:genetics; D008752:Methylene Chloride / Q000737:chemistry; D009016:Moraxella / Q000201:enzymology / Q000235:genetics; D013750:Tetrachloroethylene / Q000737:chemistry; D014871:Water Microbiology; D014874:Water Pollutants, Chemical / Q000378:metabolism*; D015262:Xenobiotics / Q000378:metabolism*
chemical_list: D006873:Hydroquinones; D014874:Water Pollutants, Chemical; D015262:Xenobiotics; D008752:Methylene Chloride; C044578:2,3,5,6-tetrachlorohydroquinone; D005982:Glutathione Transferase; D006867:Hydrolases; C034507:2-haloacid dehalogenase; C046137:haloalkane dehalogenase; D008190:Lyases; C045224:dichloromethane dehalogenase; D013750:Tetrachloroethylene