[Effect of the maternal environment on blood pressure and startle reflex in rats with inherited hypertension].
In a long-term study comprising adolescence (6 weeks of age) and adulthood, acoustic startle response (ASR) and arterial blood pressure (ABP) were studied in the ISIAH (inherited stress-induced arterial hypertension) rats, in normotensive Wistar, and cross-fostered rats. The 6-week ISIAH rats already revealed a hypertension enhanced ASR as well as a reduced habituation as compared with the control rats. Maternal effects on the ASR and, to a lesser extent, on the ABP were revealed in cross-fostered rats. In young ISIAH rats fostered by Wistar surrogate mothers, the ASR was decrease and development of hypertension was delayed. There was no significant difference in expression of the ASR between adult ISIAH and Wistar rats whereas the ABP difference was quite obvious.
Amstislavskiĭ
S Ia
SIa
Institute of Cytology and Genetics of the Russian Acad. Sci., Siberian Branch, Russia.
Popova
N K
NK
Tomilova
Iu E
IuE
Basova
I Iu
IIu
Markel'
A L
AL
D000818:Animals; D001794:Blood Pressure; D005260:Female; D006973:Hypertension / Q000235:genetics / Q000503:physiopathology*; D008297:Male; D008425:Maternal Behavior; D051381:Rats; D017208:Rats, Wistar; D013216:Reflex, Startle; D012931:Social Environment; D013045:Species Specificity
Vliianie materinskoĭ sredy na arterial'noe davleniie i reflex ispuga u krys s nasledstvennoĭ arterial'noĭ gipertenzieĭ.