Cisplatin delivery by biodegradable polymer implant is superior to systemic delivery by osmotic pump or i.p. injection in tumor-bearing mice.
The use of biodegradable polymer implants to deliver cisplatin was compared with delivery by systemic injection and by osmotic pump. Drug levels in the tumor were found to be higher than those in the blood and kidney when the drug was delivered using the polymer implant. In contrast, for the other two delivery methods blood and kidney cisplatin levels were greater than those in the tumor. It has been previously shown that tumor response, in terms of growth delay, was greatest when drug was delivered by polymer implant and least when treatment was by osmotic pump.
Yapp
D T
DT
Department of Medical Oncology, McGill University, Montréal, Québec, Canada.
Lloyd
D K
DK
Zhu
J
J
Lehnert
S M
SM
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D001672:Biocompatible Materials / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D004337:Drug Carriers; D016503:Drug Delivery Systems / Q000379:methods*; D004343:Drug Implants; D005260:Female; D015918:Infusion Pumps, Implantable; D015552:Injections, Intralesional; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000378:metabolism; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism*; D011108:Polymers / Q000008:administration & dosage
D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D004337:Drug Carriers; D004343:Drug Implants; D011108:Polymers; D002945:Cisplatin