B- and T-cell epitopes of tropomyosin, the major shrimp allergen.
The major crustacean allergen characterized from different species of shrimp is the muscle protein tropomyosin. Two shared epitopes corresponding to 47-63 and 150-158 of the deduced amino-acid sequence of the brown shrimp, M. ensis, were identified as IgE-binding B-cell epitopes. A 21-mer peptide spanning the amino-acid residues 261-281 was identified as a putative T-cell epitope capable of reducing ongoing tropomyosin-specific IgG and IgE responses in a mouse model. These observations suggest that peptide immunotherapy may also be effective in the treatment of food hypersensitivity.
Subba Rao
P V
PV
Department of Biochemistry, Indian Institute of Science, Vittal Mallya Scientific Research Foundation, Bangalore.
Rajagopal
D
D
Ganesh
K A
KA
D000485:Allergens / Q000276:immunology*; D000595:Amino Acid Sequence; D000818:Animals; D033364:Decapoda / Q000276:immunology*; D018985:Epitopes, B-Lymphocyte; D018984:Epitopes, T-Lymphocyte; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D014335:Tropomyosin / Q000276:immunology*
D000485:Allergens; D018985:Epitopes, B-Lymphocyte; D018984:Epitopes, T-Lymphocyte; D014335:Tropomyosin