title: In situ fluoride retention in enamel and dentine after the use of an amine fluoride dentifrice and amine fluoride/sodium fluoride mouthrinse.
abstract: The aim of this in situ investigation was to study the effect of an amine fluoride/sodium fluoride mouthrinse (total F = 250 ppm) in addition to an amine fluoride dentifrice (F = 1,250 ppm) on the amount of acquired fluoride in enamel and dentine. In the partial prosthesis of 12 participants a combined specimen of slightly demineralized enamel and dentine was placed. During two consecutive experiments, each lasting 3 weeks, the participants used an amine fluoride dentifrice alone or in combination with a fluoride mouthrinse. After the in situ period the specimens were retrieved and both the enamel and the dentine specimens were analysed for the amount of KOH-soluble fluoride and structurally bound fluoride. The results showed a significant increase in both KOH-soluble and structurally bound fluoride in enamel and dentine when a fluoride mouthrinse was used. Whether the rinsing procedure was performed immediately after toothbrushing or with a delay of 2 h did not influence the results. Furthermore it was shown that dentine acquired substantially more fluoride than enamel during the experimental period. The results indicate that a fluoride mouthrinse used in addition to a fluoride dentifrice may have a beneficial effect on the protection of enamel and dentine against caries.
authors.affiliation: Department of Cariology, Endodontology, Pedodontology, Academic Centre for Dentistry Amsterdam (ACTA), Amsterdam, The Netherlands. a.vstrijp@acta.nl
authors.forename: A A
authors.initials: AA
authors.lastname: van Strijp
authors.forename: M J
authors.initials: MJ
authors.lastname: Buijs
authors.forename: J M
authors.initials: JM
authors.lastname: ten Cate
mesh_terms: D000327:Adsorption; D000368:Aged; D000588:Amines / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000818:Animals; D002327:Cariostatic Agents / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002417:Cattle; D003743:Dental Enamel / Q000737:chemistry / Q000378:metabolism*; D003802:Dentifrices / Q000493:pharmacokinetics* / Q000627:therapeutic use; D003804:Dentin / Q000737:chemistry / Q000378:metabolism*; D003832:Denture, Partial, Removable; D004357:Drug Synergism; D005460:Fluorides, Topical / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006801:Humans; D006878:Hydroxides / Q000737:chemistry; D008875:Middle Aged; D009067:Mouthwashes / Q000493:pharmacokinetics* / Q000627:therapeutic use; D017680:Potassium Compounds / Q000737:chemistry; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics* / Q000627:therapeutic use; D012995:Solubility; D014002:Tin Fluorides / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics* / Q000627:therapeutic use; D017001:Tooth Demineralization / Q000188:drug therapy / Q000378:metabolism
chemical_list: D000588:Amines; D002327:Cariostatic Agents; D003802:Dentifrices; D005460:Fluorides, Topical; D006878:Hydroxides; D009067:Mouthwashes; D017680:Potassium Compounds; D014002:Tin Fluorides; C094808:amine fluoride solution; C075174:amine fluoride gel; D012969:Sodium Fluoride; C029943:potassium hydroxide