Local delivery of chemotherapeutic agents in periodontal therapy: has its time arrived?
The concept of locally delivering chemotherapeutic agents to the periodontal pocket as a method to treat periodontal disease has been studied for over 20 years. A number of locally delivered chemotherapeutic agents in periodontal therapy are either currently available or under investigation. Clinical efficacy derives from sustained-release technology to maintain an effective concentration of drug within the periodontal pocket for a clinically relevant length of time. Studied drugs have mainly been antimicrobials, both antibiotics and antiseptics. Most agents have been tested as adjuncts to scaling and root planing; a few have been studied as stand-alone monotherapies. Collectively, the data indicate that the use of locally delivered antimicrobials as adjuncts results in a significant increase in the reduction of probing depth compared with scaling and root planing alone. In other trials, results in reducing probing depth following the use of stand-alone locally delivered antimicrobials have been equivalent to those of scaling and root planing over a specified time. This Symposium was organized to present the current state-of-the-art with regard to the use of locally delivered antimicrobials in the treatment of periodontal disease. 5 experts in the field who have had considerable experience in studying locally delivered antimicrobials presented data. These speakers reviewed the clinical findings regarding efficacy of 5 different antimicrobial agents. An ensuing panel discussion was to consider treatment recommendations for locally delivered antimicrobials.
Finkelman
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RD
Clinical Research, Medical Affairs, Astra Pharmaceuticals, L.P., Westborough, MA 01581-4500, USA. richard.finkelman@astra.us.astra.com
Williams
R C
RC
D000287:Administration, Topical; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D003692:Delayed-Action Preparations; D006801:Humans; D010510:Periodontal Diseases / Q000188:drug therapy*
D000890:Anti-Infective Agents; D003692:Delayed-Action Preparations