Syndecan-3 in limb skeletal development.
Syndecan-3 is a member of a family of heparan sulfate proteoglycans that function as extracellular matrix receptors and as co-receptors for growth factors and signalling molecules. A variety of studies indicate that syndecan-3 is involved in several aspects of limb morphogenesis and skeletal development. Syndecan-3 participates in limb outgrowth and proliferation in response to the apical ectodermal ridge; mediates cell-matrix and/or cell-cell interactions involved in regulating the onset of chondrogenesis; may be involved in regulating the onset of osteogenesis and joint formation and, plays a role in regulating the proliferation of epiphyseal chondrocytes during endochondral ossification.
Kosher
R A
RA
Department of Anatomy, University of Connecticut Health Center, Farmington 06030, USA. kosher@sun.uchc.edu
D000818:Animals; D001846:Bone Development / Q000502:physiology*; D005121:Extremities / Q000196:embryology* / Q000502:physiology; D006801:Humans; D008562:Membrane Glycoproteins / Q000502:physiology*; D011509:Proteoglycans / Q000502:physiology*; D017468:Receptors, Fibroblast Growth Factor / Q000502:physiology*; D053670:Syndecan-3
D008562:Membrane Glycoproteins; D011509:Proteoglycans; D017468:Receptors, Fibroblast Growth Factor; C508301:SDC3 protein, human; D053670:Syndecan-3