Failure of sorivudine therapy in progressive outer retinal necrosis caused by varicella zoster virus.
BACKGROUND
We report on the case of a 23-year-old female who presented with ocular signs of progressive outer retinal necrosis (PORN) syndrome and who failed to respond to acyclovir, ganciclovir, foscarnet and oral sorivudine.


METHODS
The patient was treated with the antiviral drugs acyclovir, ganciclovir, foscarnet and oral sorivudine.


RESULTS
The patient failed to respond to a combination of antiviral drugs. Unfortunately, progression of the retintis occurred, which led to blindness.


CONCLUSIONS
Despite new drugs, the prognosis of PORN is poor and recurrence is common.
Rosenthal
G
G
Department of Vitreoretinal Surgery, University of Cologne, Germany. gidir@ramat-negev.org.il
Bartz-Schmidt
K U
KU
Walter
P
P
Kirchhof
B
B
Heimann
K
K
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy* / Q000503:physiopathology / Q000821:virology; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D000998:Antiviral Agents / Q000627:therapeutic use*; D001086:Arabinofuranosyluracil / Q000031:analogs & derivatives* / Q000627:therapeutic use; D001766:Blindness / Q000821:virology; D004279:DNA, Viral / Q000032:analysis; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006563:Herpes Zoster Ophthalmicus / Q000188:drug therapy* / Q000503:physiopathology / Q000821:virology; D014645:Herpesvirus 3, Human / Q000235:genetics / Q000276:immunology; D006801:Humans; D012008:Recurrence; D015882:Retinal Necrosis Syndrome, Acute / Q000188:drug therapy* / Q000503:physiopathology / Q000821:virology; D017211:Treatment Failure
D000914:Antibodies, Viral; D000998:Antiviral Agents; D004279:DNA, Viral; D001086:Arabinofuranosyluracil; C031368:sorivudine