title: [Juvenile cerebral ischaemia caused by designer drugs].
abstract: METHODS
  A 29-year-old man reported two episodes, 3 months apart, of dysarthria, each lasting for several hours. It was associated with hypaesthesia over the cheeks. Neurological examination several hours later was unremarkable. On direct questioning the patient reported that he had been taking marihuana and cocaine immediately before each episode. There was also a history of regular abuse of various drugs over several years by this socially well integrated young man.
  
  
  METHODS
  Cranial computed tomography, cranial magnetic resonance imaging and cerebral scintigraphy indicated multiple cortical and subcortical ischaemic lesions of different sizes and ages. ECG, long-term ECG monitoring, transoesophageal echocardiography and upper abdominal sonography were normal. Cerebrospinal fluid revealed a slightly abnormal blood-brain barrier (5.3 g/l protein, albumin ratio of 7.3). Auto-antibody titres and coagulation and serological tests for neurotropic bacteria and viruses were normal. Urinary drug screening was positive for cannabinoids.
  
  
  METHODS
  We assume that the patient had transitory cocaine-induced ischaemic attacks (TIA) and clinically silent cerebrovascular accidents (CVA). He was discharged without specific treatment after being informed of the severe neurological sequelae of his drug abuse.
  
  
  CONCLUSIONS
  The rising abuse of "designer drugs" is of increasing diagnostic significance in TIA-like symptoms and CVAs in young adults, which may be of haemorrhagic or ischaemic aetiology. Thromboembolic, vasospastic or vasculitic factors play a pathogenetic role. Early performance of appropriate blood and urine tests is of great diagnostic importance.
authors.affiliation: Neurologische Klinik, Universität Würzburg. neuk156@mail.uni-wuerzburg.de
authors.forename: R
authors.initials: R
authors.lastname: Giess
authors.forename: P
authors.initials: P
authors.lastname: Rieckmann
authors.forename: W
authors.initials: W
authors.lastname: Müllges
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology; D019970:Cocaine-Related Disorders / Q000150:complications; D015198:Designer Drugs / Q000009:adverse effects*; D004562:Electrocardiography; D006801:Humans; D002546:Ischemic Attack, Transient / Q000139:chemically induced*; D008297:Male; D002189:Marijuana Abuse / Q000150:complications; D014055:Tomography, Emission-Computed
chemical_list: D015198:Designer Drugs
vernacular_title: Juvenile zerebrale Ischämien durch Designerdrogen.