Reversible inactivation of the medial septum or nucleus basalis impairs working memory in rats: a dissociation of memory and performance.
Lidocaine-induced inactivation of the medial septum immediately after training or prior to testing in a delay radial-arm maze task produced deficits in spatial working memory that reflected impaired acquisition of the task. Injection of lidocaine into the nucleus basalis magnocellularis produced a profile of behavioral changes that indicated that temporary inactivation of this structure impaired the behavioral expression of information already stored in working memory. This appears to reflect an impairment in processes that are required for performance (i.e., attention, motivation, sensorimotor function) of the task but not for retrieval of stored information. Site-specific inactivation of the basal forebrain should help to reveal the involvement of its component structures in different aspects of cognitive function.
Walsh
T J
TJ
Department of Psychology, Rutgers, The State University of New Jersey, Busch Campus, New Brunswick 08903, USA. tomw@rci.rutgers.edu
Gandhi
C
C
Stackman
R W
RW
D000704:Analysis of Variance; D000818:Animals; D001479:Basal Ganglia / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology*; D001522:Behavior, Animal / Q000502:physiology*; D005625:Frontal Lobe / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology*; D008012:Lidocaine / Q000008:administration & dosage; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D008569:Memory Disorders / Q000503:physiopathology*; D008570:Memory, Short-Term / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D008012:Lidocaine