title: Mutagenicity of cooked hamburger is reduced by addition of onion to ground beef.
abstract: Addition of onion effectively reduced mutagenicity of cooked hamburger when tested on Salmonella typhimurium TA98 strain with metabolic activation. The components of onion that participated in the reduction of mutagenicity were sugars. Addition of starch or glucose to ground beef the amount equivalent to that in onion reduced the mutagenicity of cooked hamburger. Addition of onion may cause imbalance of the sugar content of ground beef that effectively produces mutagenicity. Mutagenicity of the heated model mixture of glucose/glycine/creatinine in diethyleneglycol-water was reduced by an excessive amount of glucose. Hence, Japanese cooking-style with addition of onion can reduce mutagenicity of hamburger.
authors.affiliation: Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kato
authors.forename: K
authors.initials: K
authors.lastname: Michikoshi
authors.forename: Y
authors.initials: Y
authors.lastname: Minowa
authors.forename: Y
authors.initials: Y
authors.lastname: Maeda
authors.forename: K
authors.initials: K
authors.lastname: Kikugawa
mesh_terms: D000818:Animals; D002241:Carbohydrates / Q000032:analysis; D002417:Cattle; D003404:Creatinine / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D005998:Glycine / Q000494:pharmacology; D008461:Meat Products / Q000633:toxicity*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D019697:Onions / Q000737:chemistry / Q000378:metabolism*; D012486:Salmonella typhimurium / Q000235:genetics
chemical_list: D002241:Carbohydrates; D009153:Mutagens; D003404:Creatinine; D005947:Glucose; D005998:Glycine