Elevated serum IL-8 levels are associated with disease activity in idiopathic intermediate uveitis.
OBJECTIVE
To find a laboratory indicator for systemic involvement in intermediate uveitis.


METHODS
Interleukin 8 (IL-8) and C reactive protein (CRP) serum levels were measured in patients with idiopathic intermediate uveitis (n = 61), uveitis controls (n = 143), and normal controls (n = 29). The records of those with intermediate uveitis were reviewed with the emphasis on disease activity and severity as characterised by the presence of cystoid macular oedema, vitreous exudates or snowbank formation, papillitis, and periphlebitis.


RESULTS
Increased serum IL-8 (> or = 20 pg/ml) was found in 27 out of 61 patients with intermediate uveitis (p < 0.01), 12 of 27 patients with sarcoid uveitis (p < 0.05), in 19 of 30 patients with HLA-B27 associated acute anterior uveitis (p < 0.05), and in five of 29 healthy controls. Raised IL-8 levels in intermediate uveitis were significantly associated with active disease (p < 0.001) and the presence of vitreous exudates (p < 0.001), papillitis, and periphlebitis (p < 0.01). Elevated CRP levels were found in 12 of the 143 uveitis controls but in none of the intermediate uveitis patients or normal controls. During follow up an associated systemic disease was more frequently noticed in patients with an elevated serum IL-8 at entry into the study.


CONCLUSIONS
Elevated IL-8 serum levels were found in patients with active intermediate uveitis of unknown origin. An elevated IL-8 level seems to predispose the patient to a later development of associated systemic disease.
Klok
A M
AM
Department of Ophthalmo-Immunology, Netherlands Ophthalmic Research Institute, Amsterdam.
Luyendijk
L
L
Zaal
M J
MJ
Rothova
A
A
Hack
C E
CE
Kijlstra
A
A
D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D015796:HLA-B27 Antigen / Q000032:analysis; D006801:Humans; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012507:Sarcoidosis / Q000150:complications / Q000276:immunology; D012720:Severity of Illness Index; D014606:Uveitis, Anterior / Q000276:immunology; D015867:Uveitis, Intermediate / Q000209:etiology / Q000276:immunology*
D015415:Biomarkers; D015796:HLA-B27 Antigen; D016209:Interleukin-8; D002097:C-Reactive Protein