title: Pretreatment with intralesional hyaluronidase prior to excision of dermatofibrosarcoma protuberans.
abstract: Dermatofibrosarcoma protuberans (DFSPs) are an uncommon malignancy that commonly recur, but rarely metastasize. The origin of DFSPs is controversial; however, they stain with the progenitor marker CD34. DFSPs usually show increased stromal mucin, mainly hyaluronic acid (HA). HA increases cellular proliferation, delays differentiation and increases cellular motion. We evaluated the pretreatment of DFSPs with intralesional injections of hyaluronidase (HD) prior to the surgical excision. Five of nine cases of DFSPs were pretreated with HD. In HD-pretreated cases the margins for excision of the residual tumor were reduced. HD pretreatment also decreased CD34 staining and increased polarizable collagen in the residual tumor.
authors.affiliation: Department of Dermatology, National Naval Medical Center, Bethesda, MD 20889-5600, USA.
authors.forename: K
authors.initials: K
authors.lastname: Smith
authors.forename: P
authors.initials: P
authors.lastname: Menon
authors.forename: A
authors.initials: A
authors.lastname: Rolfe
authors.forename: M
authors.initials: M
authors.lastname: Welch
authors.forename: T
authors.initials: T
authors.lastname: Barrett
authors.forename: M J
authors.initials: MJ
authors.lastname: Crittenden
authors.forename: H
authors.initials: H
authors.lastname: Skelton
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018223:Dermatofibrosarcoma / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D005260:Female; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D010865:Pilot Projects; D012878:Skin Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*
chemical_list: D006821:Hyaluronoglucosaminidase