title: Human immunodeficiency virus type 1 subtypes differ in disease progression.
abstract: At least 10 different genetic human immunodeficiency virus type 1 (HIV-1) subtypes (A-J) are responsible for the AIDS pandemic. Much of the understanding of HIV-1 disease progression derives from studies in the developed world where HIV infection is almost exclusively subtype B. This has led many to question whether the properties and consequences of HIV-1 infection can be generalized across subtypes that afflict the majority of infected persons in the developing world. From 1985 to 1997, a prospective study of registered female sex workers in Senegal tracked the introduction and spread of HIV-1 subtypes A, C, D, and G. In clinical follow-up, the AIDS-free survival curves differed by HIV-1 subtype. Women infected with a non-A subtype were 8 times more likely to develop AIDS than were those infected with subtype A (hazard ratio=8.23; P=. 009), the predominant subtype in the study. These data suggest that HIV-1 subtypes may differ in rates of progression to AIDS.
authors.affiliation: Department of Immunology, Harvard School of Public Health, Boston, Massachusetts, USA. pkanki@hsph.harvard.edu
authors.forename: P J
authors.initials: PJ
authors.lastname: Kanki
authors.forename: D J
authors.initials: DJ
authors.lastname: Hamel
authors.forename: J L
authors.initials: JL
authors.lastname: Sankalé
authors.forename: C c
authors.initials: Cc
authors.lastname: Hsieh
authors.forename: I
authors.initials: I
authors.lastname: Thior
authors.forename: F
authors.initials: F
authors.lastname: Barin
authors.forename: S A
authors.initials: SA
authors.lastname: Woodcock
authors.forename: A
authors.initials: A
authors.lastname: Guèye-Ndiaye
authors.forename: E
authors.initials: E
authors.lastname: Zhang
authors.forename: M
authors.initials: M
authors.lastname: Montano
authors.forename: T
authors.initials: T
authors.lastname: Siby
authors.forename: R
authors.initials: R
authors.lastname: Marlink
authors.forename: I
authors.initials: I
authors.lastname: NDoye
authors.forename: M E
authors.initials: ME
authors.lastname: Essex
authors.forename: S
authors.initials: S
authors.lastname: MBoup
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000209:etiology / Q000401:mortality; D001483:Base Sequence; D017931:DNA Primers / Q000235:genetics; D005260:Female; D015658:HIV Infections / Q000453:epidemiology / Q000635:transmission / Q000821:virology*; D006679:HIV Seropositivity; D015497:HIV-1 / Q000145:classification* / Q000235:genetics / Q000472:pathogenicity; D006801:Humans; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D011446:Prospective Studies; D012675:Senegal / Q000453:epidemiology; D011477:Sex Work; D015996:Survival Rate; D013997:Time Factors
chemical_list: D017931:DNA Primers