title: The virulence of Staphylococcus aureus isolates differing by siderophore production.
abstract: In previous study we demonstrated that Staphylococci aureus clinical and environmental isolates differ by siderophore production (Lisiecki et al., 1997), the aim of the present study was to check a possible role of siderophore-dependent iron acquisition system of outcome of staphylococcal diseases. The systemic and local staphylococcal infections were induced in mice by inoculation of three S. aureus strains differing by siderophore production. We found that S. aureus B 47 strain characterized by enhanced siderophore activity was more virulent in both systemic and local infection models and it was more resistant to anti-bacterial activity of neutrophils than S. aureus B 63 and B 32 strains expressing weaker siderophore production. The results suggest that effective siderophore-dependent iron acquisition system may be beneficial to S. aureus strains in their pathogenic activity in vivo.
authors.affiliation: Department of Infectious Biology, Institute of Microbiology and Immunology, University of Lódź, Poland.
authors.forename: B
authors.initials: B
authors.lastname: Rózalska
authors.forename: P
authors.initials: P
authors.lastname: Lisiecki
authors.forename: B
authors.initials: B
authors.lastname: Sadowska
authors.forename: J
authors.initials: J
authors.lastname: Mikucki
authors.forename: W
authors.initials: W
authors.lastname: Rudnicka
mesh_terms: D000818:Animals; D001431:Bacteriological Techniques; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C / Q000382:microbiology; D009504:Neutrophils / Q000382:microbiology; D010529:Peritoneal Cavity / Q000166:cytology; D010587:Phagocytosis / Q000276:immunology; D017262:Siderophores / Q000096:biosynthesis*; D013211:Staphylococcus aureus / Q000254:growth & development / Q000276:immunology / Q000472:pathogenicity*; D014774:Virulence
chemical_list: D017262:Siderophores