title: [Cefuroxime Bayesian pharmacokinetics in severely ill septic children].
abstract: OBJECTIVE
  To estimate the cefuroxime pharmacokinetic parameters in critically ill pediatric septic patients using a Bayesian pharmacokinetic method and three serum drug assays per patient.
  
  
  METHODS
  Cross-sectional study of critically ill pediatric patients undergoing therapeutic monitoring of cefuroxime serum concentrations.
  
  
  METHODS
  Tertiary care center.
  
  
  METHODS
  Nine critically ill pediatric patients with sepsis and septic shock treated with cefuroxime.
  
  
  METHODS
  Timed serum concentrations of cefuroxime were obtained in each patient. The Vd (volume of distribution) and the Kel (constant of elimination) were estimated by means of a Bayesian iterative two-stage algorithm, using the information of three serum drug concentrations per patient at optimal times. The parameters were also estimated by the traditional method of non linear least square regression in eight samples.
  
  
  RESULTS
  The Bayesian Vd was very similar to the traditional Vd with a correlation coefficient of 0.99 and a small bias of -0.04 L/kg whereas the Kel had a correlation of 0.90 and bias of -0.29 h-1. The mean Bayesian Vd was 0.68 L/kg, a larger value than that reported in non critically ill patients.
  
  
  CONCLUSIONS
  We offer a tentative cefuroxime pharmacokinetic model for critically ill pediatric septic patients which may be useful for the control of cefuroxime serum concentrations. Also, our study underscored the potential usefulness of a Bayesian pharmacokinetic approach as a tool for therapeutic drug monitoring in critically ill patients.
authors.affiliation: Departamento de Farmacología, Salud Infantil-INP, México, D.F. lares@mailer.main.conacyt.mx
authors.forename: I
authors.initials: I
authors.lastname: Lares-Asseff
authors.forename: G
authors.initials: G
authors.lastname: Lugo-Goytía
authors.forename: M G
authors.initials: MG
authors.lastname: Pérez-Guillé
authors.forename: J
authors.initials: J
authors.lastname: Flores-Pérez
authors.forename: H
authors.initials: H
authors.lastname: Juárez-Olguín
authors.forename: M A
authors.initials: MA
authors.lastname: Raquel Moreno
mesh_terms: D000293:Adolescent; D001499:Bayes Theorem; D002444:Cefuroxime / Q000493:pharmacokinetics*; D002511:Cephalosporins / Q000493:pharmacokinetics*; D002648:Child; D002675:Child, Preschool; D016638:Critical Illness; D006801:Humans; D007223:Infant; D012044:Regression Analysis; D018805:Sepsis / Q000378:metabolism*; D012772:Shock, Septic / Q000378:metabolism
chemical_list: D002511:Cephalosporins; D002444:Cefuroxime
vernacular_title: Farmacocinética bayesiana de cefuroxima en niños infectados gravemente enfermos.