title: Failure of pristinamycin treatment in a case of pneumonia caused by a streptogramins B-type resistant pneumococcus.
abstract: We report a failure of pristinamycin treatment in a case of pneumonia caused by streptogramins B-type resistant pneumococcus. We suggest that (i) streptogramins therapy should be avoided, if a previous treatment failure has been observed with a macrolide and/or if the antibiogram shows the MLS(B) co-resistance phenotype, and (ii) beta-lactams should remain the first-line antibiotics used for treatment of pneumococcal respiratory infections.
authors.affiliation: Service de Médecine Interne, Hôpital Général, Rodez, France.
authors.forename: F
authors.initials: F
authors.lastname: Brevet-Coupe
authors.forename: B
authors.initials: B
authors.lastname: Guerin
authors.forename: J
authors.initials: J
authors.lastname: Watine
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D011018:Pneumonia, Pneumococcal / Q000188:drug therapy* / Q000382:microbiology*; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D017211:Treatment Failure; D014769:Virginiamycin / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D014769:Virginiamycin