title: Sentinel node biopsy in patients with cutaneous melanoma.
abstract: The role of elective lymph node dissection (ELND) for treatment of cutaneous melanoma is still debated. Initially, lymphatic mapping technique was performed by an intradermic injection of vital blue dye; subsequently, it was improved by the use of radioguided surgery (RGS). Preliminary experience with this technique proved effective for detection of clinical occult lymph node metastasis; it may also enable the surgeon to perform a selective lymph node dissection (SLND) to concentrate on pathologic node-positive patients for the same potential benefits that have been provided by ELND. We performed sentinel node biopsy on 48 patients with stage pT3N0M0 melanoma. Vital blue dye mapping only was carried out on 39 patients; the remaining nine patients had a combined lymphatic mapping with both blue dye and RGS. The sentinel lymph node (SLN) was identified in 46 of 48 patients (95.8%). Ten patients (20.8%) were found to have metastatic melanoma cells in their SLN(s); all these patients underwent SLND of the affected basin. Our findings confirm that the intraoperative lymphatic mapping of the SLN using both blue dye and radiodetection is an appropriate and simple technique for selecting patients who are more likely to benefit from lymph node dissection.
authors.affiliation: Department of Clinical and Experimental Oncology, University of Genoa, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Cafiero
authors.forename: A
authors.initials: A
authors.lastname: Peressini
authors.forename: M
authors.initials: M
authors.lastname: Gipponi
authors.forename: M L
authors.initials: ML
authors.lastname: Rainero
authors.forename: G
authors.initials: G
authors.lastname: Villa
authors.forename: M R
authors.initials: MR
authors.lastname: Sertoli
authors.forename: S
authors.initials: S
authors.lastname: Bertoglio
authors.forename: L
authors.initials: L
authors.lastname: Moresco
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D004396:Coloring Agents; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008545:Melanoma / Q000000981:diagnostic imaging* / Q000556:secondary / Q000601:surgery; D008875:Middle Aged; D009367:Neoplasm Staging; D018579:Patient Selection; D011237:Predictive Value of Tests; D016719:Radioimmunodetection; D012878:Skin Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D013668:Technetium Tc 99m Aggregated Albumin
chemical_list: D004396:Coloring Agents; D013668:Technetium Tc 99m Aggregated Albumin