title: The influence of enzyme-resistant starch on cholesterol metabolism in rats fed on a conventional diet.
abstract: Male Wistar rats were fed on a conventional diet containing normal corn starch or 6% enzyme-resistant starch originating from either raw or retrograded high-amylose corn starch. Furthermore, the diets were either cholesterol-free or contained 1% cholesterol and 0.1% cholic acid. The main objective of this study was to investigate whether the addition of enzyme-resistant starch to a rat conventional diet had any effect on cholesterol metabolism. Therefore, plasma and liver cholesterol concentrations, plasma HDL:LDL cholesterol ratios and neutral steroid and bile acid excretion were determined. No significant effect of enzyme-resistant starch feeding on plasma and liver cholesterol concentrations was found. However, consumption of raw or retrograded high-amylose corn starch resulted in a decrease in esterified and total liver cholesterol concentrations of 24 and 22%, respectively. This was accompanied by a reduction in plasma esterified and total cholesterol levels of 4% and a tendency to higher daily faecal coprostanol and total bile acid excretion.
authors.affiliation: Laboratory of Nutrition, Catholic University of Leuven, Belgium.
authors.forename: K
authors.initials: K
authors.lastname: Vanhoof
authors.forename: R
authors.initials: R
authors.lastname: De Schrijver
mesh_terms: D000688:Amylose; D000821:Animal Feed; D000818:Animals; D001647:Bile Acids and Salts / Q000032:analysis; D004083:Cholestanol / Q000032:analysis; D002784:Cholesterol / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D005243:Feces / Q000737:chemistry; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013213:Starch / Q000008:administration & dosage*; D003313:Zea mays
chemical_list: D001647:Bile Acids and Salts; D004083:Cholestanol; D013213:Starch; D000688:Amylose; D002784:Cholesterol