Antinociceptive activity of metamizol in rats with experimental ureteric calculosis: central and peripheral components.
OBJECTIVE
To study the antinociceptive effects of metamizol in a rat model of ureteric calculosis.


METHODS
Adult female Wistar rats (n = 40).


METHODS
Metamizol was given i.p. 50-100 mg/kg, 3 times daily for 4 days for behavioural testing, and 25-100 mg/kg i.v. whilst recording peristalsis or dorsal horn neurons.


METHODS
An artificial stone was induced in one ureter. In 3 separate groups of stone-implanted rats, behaviour was recorded continuously on video tape, ureteric peristalsis or the electrical activity of single nociceptive dorsal horn neurons with ureteric input was recorded under anaesthesia. Data were compared with analysis of variance.


RESULTS
Metamizol inhibited the behavioural visceral crises, the abnormal ureteric peristalsis and the activity of nociceptive dorsal horn neurons.


CONCLUSIONS
Metamizol has central antinociceptive effects on the pain produced by a ureteric stone, and an additional spasmolytic effect on the hyperperistalsis produced by the stone.
Laird
J M
JM
Dpto. Fisiología, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain. fflaird@fisfar.alcala.es
Roza
C
C
Olivar
T
T
D015746:Abdominal Pain / Q000188:drug therapy; D000698:Analgesia; D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004177:Dipyrone / Q000627:therapeutic use*; D005260:Female; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013116:Spinal Cord / Q000187:drug effects / Q000503:physiopathology; D014513:Ureter / Q000294:innervation / Q000503:physiopathology; D014514:Ureteral Calculi / Q000188:drug therapy* / Q000503:physiopathology*
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004177:Dipyrone