G-CSF: a very efficient therapy in chronic autoimmune neutropenia. A brief review of the literature.
Autoimmune neutropenia (AIN) is a rare hematological disorder for which no standard treatment has been established so far. A brief review of the literature is presented herein concerning the use of G-CSF in this indication. The good results in terms of neutrophils increment and infection prophylaxis render G-CSF attractive for treating AIN. Hypotheses explaining its mechanisms of action are also discussed.
Bauduer
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Service des Maladies du Sang, Centre Hospitalier de la Côte Basque, Bayonne, France.
D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000276:immunology; D002908:Chronic Disease; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D009503:Neutropenia / Q000188:drug therapy* / Q000276:immunology; D016896:Treatment Outcome
D016179:Granulocyte Colony-Stimulating Factor