title: Molecular epidemiology and trends of HIV-1 subtypes in Taiwan.
abstract: To understand the trends of distribution and risk factors associated with different HIV-1 subtypes in different populations in Taiwan, blood samples and questionnaires were collected from 267 male and 21 female HIV-1-infected people in a multicenter survey from 1993 to 1996. This group represented about one quarter of the total registered HIV-1 cases in Taiwan. The HIV-1 subtypes were determined using V3-based peptide-enzyme immunoassays complemented by heteroduplex mobility assay and phylogenetic tree analysis. The results showed that in Taiwan, men were primarily infected with HIV-1B (68.2%) and HIV-1E (27.3%), whereas women were mainly infected with non-B subtypes (4.8% A, 4.8% C, 71.4% E, and 9.5% G). In addition, 71.4% of men with HIV-1B were homosexual or bisexual, whereas 56.2% of men with HIV-1E were heterosexual (p < .001). Although HIV-1E subtype came to Taiwan later than HIV-1B, it has become a major subtype in the heterosexual population.
authors.affiliation: AIDS Prevention and Research Center, Institute of Public Health, School of Medicine, National Yang-Ming University, Taipei, Taiwan, Republic of China. arthur@ym.edu.tw
authors.forename: Y M
authors.initials: YM
authors.lastname: Chen
authors.forename: C M
authors.initials: CM
authors.lastname: Lee
authors.forename: R Y
authors.initials: RY
authors.lastname: Lin
authors.forename: H J
authors.initials: HJ
authors.lastname: Chang
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000821:virology; D000328:Adult; D000595:Amino Acid Sequence; D001727:Bisexuality; D019143:Evolution, Molecular; D005260:Female; D006069:Gonorrhea / Q000150:complications; D015483:HIV Antibodies; D015699:HIV Envelope Protein gp120 / Q000737:chemistry / Q000235:genetics*; D015658:HIV Infections / Q000453:epidemiology* / Q000635:transmission / Q000821:virology*; D015497:HIV-1 / Q000235:genetics* / Q000302:isolation & purification; D006306:Health Surveys; D020010:Heterosexuality; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000737:chemistry / Q000276:immunology; D010802:Phylogeny; D012307:Risk Factors; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D012727:Sex Characteristics; D011477:Sex Work; D013587:Syphilis / Q000150:complications; D013624:Taiwan / Q000453:epidemiology
chemical_list: D015483:HIV Antibodies; D015699:HIV Envelope Protein gp120; D010446:Peptide Fragments