title: Assessment of the biomechanical state of intracranial tissues by dynamic MRI of cerebrospinal fluid pulsations: a phantom study.
abstract: We used a cranial phantom to investigate how intracranial mechanical factors [brain compliance and the resistance to the flow of cerebrospinal fluid (CSF)] affect the way in which CSF pulsations are driven by pulsatile transcranial blood flow. Dynamic phase-contrast magnetic resonance imaging (MRI) was used to measure the transfer function between vascular pulsations and pulsatile response of the CSF below the foramen magnum of the phantom. We found that the coupling between the high frequency components of cervical CSF flow and transcranial blood flow was decreased when the phantom was modified to simulate increased brain compliance and increased resistance to CSF flow.
authors.affiliation: Department of Radiology, University of Chicago, IL 60637, USA.
authors.forename: D
authors.initials: D
authors.lastname: Chu
authors.forename: D N
authors.initials: DN
authors.lastname: Levin
authors.forename: N
authors.initials: N
authors.lastname: Alperin
mesh_terms: D001696:Biomechanical Phenomena; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D002555:Cerebrospinal Fluid / Q000502:physiology*; D003187:Compliance; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000175:diagnosis; D002538:Intracranial Arteriovenous Malformations / Q000175:diagnosis; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D019047:Phantoms, Imaging / Q000706:statistics & numerical data; D011673:Pulsatile Flow / Q000502:physiology*; D013577:Syndrome