Case report: a patient who developed an amoebic liver abscess during treatment with interferon.
A 65-year-old female received recombinant interferon (IFN) alpha-2b daily for the treatment of chronic hepatitis C. Fever (39 degrees C or higher) developed 14 days after the start of administration. Abdominal computed tomography suggested multiple liver abscesses, which had not been detected before IFN administration. An autopsy revealed an amoebic liver abscess. A subclinical infection of Entamoeba histolytica in this case developed into amoebic liver abscess during IFN administration.
Matsuo
T
T
Second Department of Internal Medicine, Yamagata University School of Medicine, Yamagata City, Japan.
Shinzawa
H
H
Sugahara
K
K
Mitsuhashi
H
H
Watanabe
H
H
Abe
T
T
Ohno
S
S
Terashita
M
M
Saito
K
K
Saito
T
T
Misawa
H
H
Togashi
H
H
Takahashi
T
T
D000368:Aged; D000998:Antiviral Agents / Q000009:adverse effects* / Q000627:therapeutic use; D017809:Fatal Outcome; D005260:Female; D019698:Hepatitis C, Chronic / Q000628:therapy*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000009:adverse effects* / Q000627:therapeutic use; D008101:Liver Abscess, Amebic / Q000175:diagnosis / Q000209:etiology*; D011994:Recombinant Proteins
D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins