title: Endoscopic laser treatment of progressive dysphagia in patients with advanced esophageal carcinoma.
abstract: OBJECTIVE
  The present study was designed to evaluate the treatment of malignant dysphagia by laser palliation.
  
  
  METHODS
  Between November 1994 and May 1997, 104 patients with esophageal carcinoma were subjected to endoscopic palliation with Nd-YAG laser. They were 83 men and 21 women with mean age 57+ 6.32 years. The majority of cases (94%) presented with difficulty in swallowing. Patients were treated at one-week intervals until benefit was achieved.
  
  
  RESULTS
  A tumor mass was observed in the lower third of the esophagus in 75 (72%) patients. The tumor mean length was 6 cm (range 3-10 cm). Histology revealed that 74 (71%) patients had squamous cell carcinoma and 30 (29%) patients had adenocarcinoma. Hospital mortality occurred in 6 (5.76%) cases because of esophageal perforation, fistula, or pyothorax, and late mortality occurred in 29 (27.9%) patients. Perforation occurred in 5 (4.8%). Improvement in dysphagia occurred after a mean of 3.3 (range 1-13) treatment sessions. Luminal patency allowing easy passing of the endoscope was achieved in 59 (93%) patients. Relief of symptoms and overall outcome improvement occurred in these patients in a relatively short time, there was body weight gain and an increase in serum albumin levels in 65% of patients.
  
  
  CONCLUSIONS
  In conclusion, control of dysphagia by laser palliation suggests that endoscopic laser therapy should not be regarded as being in competition with other treatment techniques such as surgery, radiation, chemotherapy, dilatation or stents, in contrast it plays a complementary role to these palliative modalities.
authors.affiliation: Gastroenterology Surgical Center, Mansoura University, Egypt.
authors.forename: M
authors.initials: M
authors.lastname: Abdel-Wahab
authors.forename: N
authors.initials: N
authors.lastname: Gad-Elhak
authors.forename: A
authors.initials: A
authors.lastname: Denewer
authors.forename: G
authors.initials: G
authors.lastname: El-Ebidy
authors.forename: A
authors.initials: A
authors.lastname: Sultan
authors.forename: A
authors.initials: A
authors.lastname: Abou-Elenin
authors.forename: O
authors.initials: O
authors.lastname: Fathy
authors.forename: M
authors.initials: M
authors.lastname: Abou-Zid
authors.forename: N
authors.initials: N
authors.lastname: El-Ghawalby
authors.forename: F
authors.initials: F
authors.lastname: Ezzat
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000628:therapy; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000628:therapy; D003680:Deglutition Disorders / Q000209:etiology / Q000628:therapy*; D004938:Esophageal Neoplasms / Q000150:complications / Q000628:therapy*; D004940:Esophageal Stenosis / Q000209:etiology / Q000628:therapy; D004945:Esophagoscopy; D005260:Female; D006801:Humans; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D010166:Palliative Care