Synthesis of new N-[4-(4-aryl- and 4-heteroaryl-1-piperazinyl)butyl]derivatives of 1-methyl-5-oxobicyclo[2.2.1]heptane-2,3-dicarboximide with an expected anxiolytic activity.
Preparation of a number of derivatives of 1-methyl-5-oxobicyclo[2.2.1]heptane-2,3-dicarboximide with a potential anxiolytic activity has been described. New analogs of Tandospirone i.e. derivatives of bicyclo[2.2.1]heptane (10), were aimed at.
Kossakowski
J
J
Department of Medical Chemistry, Medical University of Warsaw, Poland.
Zawadowski
T
T
Kuśmierczyk
J
J
D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001923:Brain Chemistry / Q000187:drug effects; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D007094:Imides / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011985:Receptors, Serotonin / Q000378:metabolism; D044263:Receptors, Serotonin, 5-HT1
C115844:1-methyl-5-oxobicyclo(2,2,1)heptane-2,3-dicarboximide; D014151:Anti-Anxiety Agents; D001643:Bridged Bicyclo Compounds; D007094:Imides; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1