Amygdala atrophy and seizure outcome after temporal lobe epilepsy surgery.
Surgical outcome in hippocampal atrophy (n = 44) and amygdalohippocampal atrophy (n = 14) were compared. Hippocampal atrophy had better seizure-free outcome than amygdalohippocampal atrophy (80% versus 50%, p = 0.043). Severity of hippocampal atrophy correlated with duration of epilepsy in patients with hippocampal atrophy (r = 0.4, p = 0.007), but not in those with amygdalohippocampal atrophy, suggesting that these two groups may have a different pathogenesis.
Ho
S S
SS
Department of Neurology, UAB Epilepsy Center, University of Alabama at Birmingham, USA.
Consalvo
D
D
Gilliam
F
F
Faught
E
E
Bilir
E
E
Morawetz
R
R
Kuzniecky
R I
RI
D000679:Amygdala / Q000473:pathology*; D001284:Atrophy; D004833:Epilepsy, Temporal Lobe / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D005500:Follow-Up Studies; D007839:Functional Laterality; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D012044:Regression Analysis; D012640:Seizures / Q000453:epidemiology / Q000503:physiopathology*; D016896:Treatment Outcome