How important is Nramp1 in tuberculosis?
The assumption that the antimicrobial resistance gene Nramp1 is a major determinant of resistance of mice to infection with virulent Mycobacterium tuberculosis can now be challenged on the basis of published evidence to the contrary. It is likely that, with tuberculosis, Nramp1-determined defenses are subordinate to other defenses.
North
R J
RJ
Trudeau Institute, Saranac Lake, NY 12983, USA. rjnorth@northnet.org
Medina
E
E
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000276:immunology*; D027682:Cation Transport Proteins; D006801:Humans; D007113:Immunity, Innate; D008264:Macrophages / Q000276:immunology*; D008565:Membrane Proteins / Q000235:genetics / Q000276:immunology*; D051379:Mice; D009163:Mycobacterium bovis / Q000276:immunology; D009169:Mycobacterium tuberculosis / Q000276:immunology; D014376:Tuberculosis / Q000276:immunology*; D000099173:Natural Resistance-associated Macrophage Protein 1
D002352:Carrier Proteins; D027682:Cation Transport Proteins; D008565:Membrane Proteins; D000099173:Natural Resistance-associated Macrophage Protein 1