title: Teratoma with trisomy 16 in a baboon (Papio hamadryas).
abstract: A teratoma was found during a planned cesarean section in a 10-year-old primigravida baboon. This teratoma had a female sex chromosome complement and trisomy for chromosome 16. This is the first report of a teratoma in a baboon and the first report of a chromosomal abnormality in a nonhuman primate teratoma. It is also the first case in a nonhuman primate to address the mechanism of origin. Through the use of genetic markers from human chromosomes 5, 8 and 17, the origin of the teratoma was shown to be most consistent with failure of meiosis II or endoreduplication in a mature ovum, while the trisomy for chromosome 16 originated after the formation of the tumor.
authors.affiliation: Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284, USA.
authors.forename: C M
authors.initials: CM
authors.lastname: Moore
authors.forename: J
authors.initials: J
authors.lastname: McKeand
authors.forename: S M
authors.initials: SM
authors.lastname: Witte
authors.forename: G B
authors.initials: GB
authors.lastname: Hubbard
authors.forename: J
authors.initials: J
authors.lastname: Rogers
authors.forename: M M
authors.initials: MM
authors.lastname: Leland
mesh_terms: D000818:Animals; D002869:Chromosome Aberrations / Q000662:veterinary; D025063:Chromosome Disorders; D017931:DNA Primers / Q000737:chemistry; D005260:Female; D006801:Humans; D007621:Karyotyping / Q000662:veterinary; D008992:Monkey Diseases / Q000235:genetics* / Q000601:surgery; D010051:Ovarian Neoplasms / Q000235:genetics / Q000601:surgery / Q000662:veterinary*; D010215:Papio; D016133:Polymerase Chain Reaction / Q000662:veterinary; D011247:Pregnancy; D013724:Teratoma / Q000235:genetics / Q000601:surgery / Q000662:veterinary*; D014314:Trisomy / Q000473:pathology*
chemical_list: D017931:DNA Primers