title: Orthotopic liver transplantation in 4 patients with portal hypertension and non-cirrhotic nodular liver.
abstract: OBJECTIVE
  Non-cirrhotic nodular liver may occasionally be associated with portal hypertension, with complications such as ascites, bleeding esophageal varices and sometimes hepatic encephalopathy. Four patients treated with transplantation are hereby described.
  
  
  METHODS
  All 4 patients had orthotopic transplantation. Cyclosporine based immunosuppression was used in all patients.
  
  
  RESULTS
  The first patient had nodular regenerative hyperplasia in the resected native liver and in the graft seven years after the transplant, what could be considered as recurrence of the disease. There were two more cases of nodular regenerative hyperplasia; one of them was diagnosed 9 years before transplantation, but he developed progressive liver failure. The fourth patient had chronic renal failure and a nodular liver. His general condition and fear of untreatable ascites after a portosystemic shunt, prompted us to perform a liver-kidney transplantation.
  
  
  CONCLUSIONS
  Portal hypertension associated with non-cirrhotic nodular liver disease can be, in general, successfully treated with medical and endoscopic measures, or in certain more serious cases with portosystemic shunting. Nevertheless, there are certain cases where liver insufficiency, associated diseases or the unawareness of the pathological diagnosis determines a liver transplantation.
authors.affiliation: Department of Pathology, Hospital Universitario 12 de Octubre, Madrid, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Loinaz
authors.forename: F
authors.initials: F
authors.lastname: Colina
authors.forename: M
authors.initials: M
authors.lastname: Musella
authors.forename: F
authors.initials: F
authors.lastname: Lopez-Rios
authors.forename: R
authors.initials: R
authors.lastname: Gomez
authors.forename: C
authors.initials: C
authors.lastname: Jimenez
authors.forename: I
authors.initials: I
authors.lastname: Gonzalez Pinto
authors.forename: I
authors.initials: I
authors.lastname: Garcia
authors.forename: E
authors.initials: E
authors.lastname: Moreno Gonzalez
mesh_terms: D000328:Adult; D002908:Chronic Disease; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications*; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000150:complications / Q000473:pathology / Q000601:surgery*; D008108:Liver Diseases, Alcoholic / Q000150:complications / Q000601:surgery; D016031:Liver Transplantation; D008297:Male; D012008:Recurrence