Reading DNA differently.
Product inhibition has provided the limiting barrier to efficient template-directed ligation and polymerization reactions. Here we review the attempts to circumvent this limitation and outline a translation strategy that does overcome the barrier and allows the information encoded in DNA to be read and amplified into backbone-modified oligonucleotides.
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G. D. Searle Chemistry Laboratory, University of Chicago, IL 60637, USA.
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D002384:Catalysis; D004247:DNA / Q000235:genetics*; D008958:Models, Molecular; D014176:Protein Biosynthesis; D013698:Templates, Genetic
D004247:DNA