title: Comparison of the effects of enucleation and orbital reconstruction using free-fat grafts, dermis grafts, and porous polyethylene implants in infant rabbits.
abstract: Twenty-nine infant rabbits from four litters were randomly assigned to three groups. No surgery was performed on left eyes. All right eyes were enucleated. Group 1, the control group, had no right-socket reconstruction. Group 2 had reconstruction using free-fat and dermis grafts. Group 3 had reconstruction using porous polyethylene implants. On attaining adult size, rabbits were killed, decapitated, and prepared for measurements. Orbital volume measurements were performed twice and orbital entrance areas were determined once. No significant differences were noted between first and second measurements of orbital volumes. Right orbital volumes were significantly smaller than left orbits in all groups except for the second measurement of the polyethylene implant group. Right orbital entrance areas were significantly smaller than left areas in the control and the free-fat and dermis graft groups. Right orbital entrance areas of the polyethylene group were not significantly smaller than the corresponding left orbital entrance areas. The use of free-fat and dermis grafts for orbital reconstruction in anophthalmic infant rabbits did not significantly stimulate orbital bone growth. In one trial, the polyethylene implant group displayed right orbital volumes and orbital entrance areas that were not significantly smaller than controls.
authors.affiliation: Arizona Centre for Plastic Surgery, University of Arizona, Tucson, USA.
authors.forename: E M
authors.initials: EM
authors.lastname: Smith
authors.forename: R M
authors.initials: RM
authors.lastname: Dryden
authors.forename: G C
authors.initials: GC
authors.lastname: Tabin
authors.forename: D
authors.initials: D
authors.lastname: Thomas
authors.forename: K W
authors.initials: KW
authors.lastname: To
authors.forename: R J
authors.initials: RJ
authors.lastname: Hofmann
mesh_terms: D000273:Adipose Tissue / Q000637:transplantation*; D000818:Animals; D000831:Animals, Newborn; D020405:Dermis / Q000637:transplantation*; D015353:Eye Enucleation; D005500:Follow-Up Studies; D009915:Orbit / Q000473:pathology / Q000601:surgery*; D020273:Orbital Implants; D016348:Osseointegration; D011095:Polyethylenes; D016062:Porosity; D011817:Rabbits; D011897:Random Allocation
chemical_list: D011095:Polyethylenes