title: Extramedullary T lymphoblastic transformation of chronic myeloid leukaemia occurring after double allogeneic transplantation.
abstract: The clinical course of chronic myeloid leukaemia (CML) is characterised by a chronic phase followed by an acute phase or blast crisis. Lymphoid transformation accounts for 20-30% of such events, with the majority of cases being of B cell origin. Extramedullary transformation occurs in approximately 10% of cases. We report a case of T cell lymphoblastic transformation in CML presenting as an extramedullary mass after allogeneic stem cell transplant. This case supports the growing evidence that CML arises in the pluripotent stem cell.
authors.affiliation: Department of Haematology, University Hospital of Wales, Cardiff, UK.
authors.forename: J
authors.initials: J
authors.lastname: Kell
authors.forename: M
authors.initials: M
authors.lastname: Booth
authors.forename: B
authors.initials: B
authors.lastname: Jones
authors.forename: M
authors.initials: M
authors.lastname: Appleton
authors.forename: S
authors.initials: S
authors.lastname: Lim
mesh_terms: D000328:Adult; D002471:Cell Transformation, Neoplastic; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000473:pathology* / Q000628:therapy; D008297:Male; D013601:T-Lymphocytes / Q000473:pathology*; D014184:Transplantation, Homologous