[Catheter-assisted techniques for decreasing the rate of restenosis after coronary angioplasty: an overview of radiotherapy].
Restenosis after percutaneous transluminal coronary angioplasty (PTCA) is a clinical problem associated with major ischemic events or repeat interventions in 20-50% of the treated patients. Systemic drug therapy has not yet been shown to prevent restenosis in clinical conditions. However, local therapeutic strategies are evolving, such as the catheter-based delivery of drugs, of antiproliferative genes, or of ionizing radiation. Experimental studies show that radiation therapy reduces restenosis rates, and preliminary clinical trials investigating a small number of patients indicate that, in particular, catheter-based radiation may be safe and effective. Randomized multicenter studies with long follow-up periods are needed to support these early results.
Hehrlein
C
C
Klinikum der Ruprecht-Karls-Universität Medizinische Klinik III Klinik für Kardiologie, Heidelberg.
Brachmann
J
J
Bode
C
C
Kübler
W
W
D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation*; D000818:Animals; D001918:Brachytherapy / Q000295:instrumentation*; D002986:Clinical Trials as Topic; D003327:Coronary Disease / Q000532:radiotherapy*; D006801:Humans; D012008:Recurrence; D015607:Stents; D016896:Treatment Outcome
Kathetergestützte Verfahren zur Verringerung der Restenoserate nach Koronarangioplastie: Ein Uberblick zur Strahlentherapie.