Expression of the ERBB2/neu and neurofibromatosis type 1 gene products in reactive and neoplastic schwann cell proliferation.
In the present study we investigated the expression of the ERBB2 protein and neurofibromin in human benign and malignant Schwann cell tumors, traumatic neuromas and peripheral nerves without pathological findings. By immunohistochemistry and Western analysis ERBB2 expression was not detectable in normal nerves but in proliferating Schwann cells of traumatic neuromas. While none of the malignant schwannomas exhibited ERBB2 expression, weak expression was seen in a small proportion of the benign schwannomas. Low levels of neurofibromin were detectable in normal nerves but not in traumatic neuromas or tumors. These data indicate an inverse expression pattern of ERBB2 and neurofibromin in human non-neoplastic Schwann cells, but not in neurinoma cells.
Schlegel
J
J
Department of Neuropathology, University Medical Center, D-35043 Marburg, Germany.
Muenkel
K
K
Trenkle
T
T
Fauser
G
G
Ruschoff
J
J
D000328:Adult; D000368:Aged; D000818:Animals; D002455:Cell Division / Q000502:physiology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009442:Neurilemmoma / Q000378:metabolism* / Q000473:pathology; D025542:Neurofibromin 1; D010524:Peripheral Nervous System Neoplasms / Q000378:metabolism* / Q000473:pathology; D014176:Protein Biosynthesis; D011506:Proteins / Q000378:metabolism; D051381:Rats; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis* / Q000378:metabolism; D012583:Schwann Cells / Q000166:cytology / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D025542:Neurofibromin 1; D011506:Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases