title: [Genetics of Alzheimer's disease].
abstract: This review reports epidemiological data and biological mechanisms about the Apolipoprotein E gene allele epsilon 4 that is a major risk factor for Alzheimer's disease (AD). The second part describes the three genes, amyloid precusor protein (APP), presenilin 1 (PS1) and presenilin 2 (PS2) genes, which when mutated cause early-onset autosomal dominant AD. Mutations on each of these genes have as a common consequence elevated levels of A beta (42,3).
authors.affiliation: Fédération de Neurologie, CHU, Rouen.
authors.forename: D
authors.initials: D
authors.lastname: Hannequin
authors.forename: D
authors.initials: D
authors.lastname: Campion
authors.forename: C
authors.initials: C
authors.lastname: Dumanchin
authors.forename: M
authors.initials: M
authors.lastname: Martinez
authors.forename: Y
authors.initials: Y
authors.lastname: Agid
authors.forename: F
authors.initials: F
authors.lastname: Clerget-Darpoux
authors.forename: T
authors.initials: T
authors.lastname: Frebourg
authors.forename: A
authors.initials: A
authors.lastname: Brice
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism / Q000523:psychology; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000378:metabolism; D005819:Genetic Markers; D006801:Humans; D012307:Risk Factors
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D005819:Genetic Markers
vernacular_title: Génétique de la maladie d'Alzheimer.