Are bacterial proteins part of the matrix of kidney stones?
An extracellular protein, produced from Pseudomonas fluorescens strain D with molecular mass of 41.5 kDa was partially purified. Its first 12 amino acid sequence shows strong similarity to a sequence reported to belong to a protein isolated from a urate-calcium oxalate stone (Binnette & Binnette, Scan Microsc1994; 2: 233-239). A possible involvement of bacterial proteins in stone matrix is discussed.
Daskalova
S
S
Department of Biochemistry and Microbiology, University of Plovdiv, 24 Tsar Assen Street, Plovdiv, 4 000, Bulgaria.
Kostadinova
S
S
Gauster
D
D
Prohaska
R
R
Ivanov
A
A
D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry / Q000302:isolation & purification*; D002848:Chromatography, DEAE-Cellulose; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007669:Kidney Calculi / Q000737:chemistry*; D008969:Molecular Sequence Data; D011551:Pseudomonas fluorescens / Q000737:chemistry*; D016415:Sequence Alignment
D001426:Bacterial Proteins