title: An unusual case of primary leptomeningeal marginal zone B-cell lymphoma.
abstract: Primary leptomeningeal lymphomas are rare, and usually follow a rapid clinical course with early systemic involvement. A 60-year-old woman presented with a 3-year history of worsening seizures and memory loss. Neuroimaging showed widespread meningeal calcification. After extensive investigations a meningeal biopsy revealed a low-grade B-cell lymphoma categorized as an extranodal marginal zone B-cell lymphoma, attributed to the same histological group as the MALT (mucosa-associated lymphoid tissue) lymphomas described in the stomach, thyroid, salivary glands and orbit. There was no evidence of systemic involvement. The extensive meningeal calcification would appear to be a novel finding in primary leptomeningeal lymphoma whereas the unusually long clinical history in this case is possibly related to the particular histological type of low-grade B-cell lymphoma.
authors.affiliation: Department of Neuropathology, Institute of Psychiatry, London, England, UK.
authors.forename: A
authors.initials: A
authors.lastname: King
authors.forename: H
authors.initials: H
authors.lastname: Wilson
authors.forename: C
authors.initials: C
authors.lastname: Penney
authors.forename: W
authors.initials: W
authors.lastname: Michael
mesh_terms: D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D008577:Meningeal Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D014057:Tomography, X-Ray Computed