Human immunodeficiency virus type 1 subtypes differ in disease progression.
At least 10 different genetic human immunodeficiency virus type 1 (HIV-1) subtypes (A-J) are responsible for the AIDS pandemic. Much of the understanding of HIV-1 disease progression derives from studies in the developed world where HIV infection is almost exclusively subtype B. This has led many to question whether the properties and consequences of HIV-1 infection can be generalized across subtypes that afflict the majority of infected persons in the developing world. From 1985 to 1997, a prospective study of registered female sex workers in Senegal tracked the introduction and spread of HIV-1 subtypes A, C, D, and G. In clinical follow-up, the AIDS-free survival curves differed by HIV-1 subtype. Women infected with a non-A subtype were 8 times more likely to develop AIDS than were those infected with subtype A (hazard ratio=8.23; P=. 009), the predominant subtype in the study. These data suggest that HIV-1 subtypes may differ in rates of progression to AIDS.
Kanki
P J
PJ
Department of Immunology, Harvard School of Public Health, Boston, Massachusetts, USA. pkanki@hsph.harvard.edu
Hamel
D J
DJ
Sankalé
J L
JL
Hsieh
C c
Cc
Thior
I
I
Barin
F
F
Woodcock
S A
SA
Guèye-Ndiaye
A
A
Zhang
E
E
Montano
M
M
Siby
T
T
Marlink
R
R
NDoye
I
I
Essex
M E
ME
MBoup
S
S
D000163:Acquired Immunodeficiency Syndrome / Q000209:etiology / Q000401:mortality; D001483:Base Sequence; D017931:DNA Primers / Q000235:genetics; D005260:Female; D015658:HIV Infections / Q000453:epidemiology / Q000635:transmission / Q000821:virology*; D006679:HIV Seropositivity; D015497:HIV-1 / Q000145:classification* / Q000235:genetics / Q000472:pathogenicity; D006801:Humans; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D011446:Prospective Studies; D012675:Senegal / Q000453:epidemiology; D011477:Sex Work; D015996:Survival Rate; D013997:Time Factors
D017931:DNA Primers