title: [Relative failure of mefloquine chemoprophylaxis on the occasion of a trip to Togo. 3 cases within the same family].
abstract: BACKGROUND
  In France, 3,500 to 4,000 cases of imported malaria are observed annually. Outcome is fatal in 30 to 50 patients, usually because of inappropriately applied preventive measures. We report three cases of imported malaria despite well-conducted chemoprophylaxis.
  
  
  METHODS
  Three members of a family who had traveled to Togo developed malaria 9 to 13 weeks after returning to France. All had taken mefloquine (1 week before travel and continued for 3 weeks after departure from Togo). The mother (aged 40 years) was treated with quinine and her son and daughter (aged 12 and 9 years) were given halofatrine. Outcome was favorable.
  
  
  CONCLUSIONS
  These familial cases illustrate the imperfect protection provided by anti-malaria chemotherapy and the continuing need for anti-vector preventive measures.
authors.affiliation: Service de Réanimation, Hôpital Marc Jacquet, Melun.
authors.forename: D
authors.initials: D
authors.lastname: Gizolme
authors.forename: M C
authors.initials: MC
authors.lastname: Receveur
authors.forename: P
authors.initials: P
authors.lastname: Bouzidi
authors.forename: P
authors.initials: P
authors.lastname: Théron
mesh_terms: D000328:Adult; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D002648:Child; D005190:Family; D005260:Female; D006801:Humans; D008288:Malaria / Q000469:parasitology / Q000517:prevention & control* / Q000635:transmission; D008297:Male; D015767:Mefloquine / Q000627:therapeutic use*; D010961:Plasmodium / Q000145:classification; D014037:Togo; D014195:Travel; D017211:Treatment Failure
chemical_list: D000962:Antimalarials; D015767:Mefloquine
vernacular_title: Echec relatif de chimioprophylaxie par méfloquine à l'occasion d'un voyage au Togo. 3 Cas au sein d'une même famille.