Deciphering RNA recognition: aminoglycoside binding to the hammerhead ribozyme.
Aminoglycoside antibiotics inhibit protein biosynthesis and various ribozymes. Structural electrostatic complementarity can explain the inhibition mechanism of the hammerhead ribozyme: positively charged ammonium groups match the negatively charged metal-ion-binding pockets created by the RNA fold's electrostatic field.
Tor
Y
Y
Department of Chemistry and Biochemistry University of California San Diego La Jolla CA 92093-0358 USA. ytor@ucsd.edu.
Hermann
T
T
Westhof
E
E
D000617:Aminoglycosides / Q000378:metabolism*; D002240:Carbohydrate Sequence; D008969:Molecular Sequence Data; D012313:RNA / Q000737:chemistry / Q000378:metabolism*; D016337:RNA, Catalytic / Q000378:metabolism*
D000617:Aminoglycosides; D016337:RNA, Catalytic; D012313:RNA