title: Health effects associated with sulfuryl fluoride and methyl bromide exposure among structural fumigation workers.
abstract: OBJECTIVE
  This study assessed the health effects associated with occupational exposure to methyl bromide and sulfuryl fluoride among structural fumigation workers.
  
  
  METHODS
  A cross-sectional study of 123 structural fumigation workers and 120 referents in south Florida was conducted. Nerve conduction, vibration, neurobehavioral, visual, olfactory, and renal function testing was included.
  
  
  RESULTS
  The median lifetime duration of methyl bromide and sulfuryl fluoride exposure among workers was 1.20 years and 2.85 years, respectively. Sulfuryl fluoride exposure over the year preceding examination was associated with significantly reduced performance on the Pattern Memory Test and on olfactory testing. In addition, fumigation workers had significantly reduced performance on the Santa Ana Dexterity Test of the dominant hand and a nonsignificantly higher prevalence of carpal tunnel syndrome than did the referents.
  
  
  CONCLUSIONS
  Occupational sulfuryl fluoride exposures may be associated with subclinical effects on the central nervous system, including effects on olfactory and some cognitive functions. However, no widespread pattern of cognitive deficits was observed. The peripheral nerve effects were likely caused by ergonomic stresses experienced by the fumigation workers.
authors.affiliation: Division of Surveillance, Hazard Evaluations and Field Studies, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA. jac6@cdc.gov
authors.forename: G M
authors.initials: GM
authors.lastname: Calvert
authors.forename: C A
authors.initials: CA
authors.lastname: Mueller
authors.forename: J M
authors.initials: JM
authors.lastname: Fajen
authors.forename: D W
authors.initials: DW
authors.lastname: Chrislip
authors.forename: J
authors.initials: J
authors.lastname: Russo
authors.forename: T
authors.initials: T
authors.lastname: Briggle
authors.forename: L E
authors.initials: LE
authors.lastname: Fleming
authors.forename: A J
authors.initials: AJ
authors.lastname: Suruda
authors.forename: K
authors.initials: K
authors.lastname: Steenland
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005431:Florida; D005651:Fumigation / Q000009:adverse effects*; D006801:Humans; D006842:Hydrocarbons, Brominated / Q000009:adverse effects*; D007306:Insecticides / Q000009:adverse effects*; D007674:Kidney Diseases / Q000139:chemically induced; D016014:Linear Models; D008171:Lung Diseases / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000139:chemically induced*; D009483:Neuropsychological Tests; D009784:Occupational Diseases / Q000139:chemically induced*; D016273:Occupational Exposure / Q000009:adverse effects*; D013441:Sulfinic Acids / Q000009:adverse effects*
chemical_list: D006842:Hydrocarbons, Brominated; D007306:Insecticides; D013441:Sulfinic Acids; C048899:sulfuryl fluoride; C005218:methyl bromide