Chronic Neuropsychological sequelae in a case of severe lithium intoxication.
OBJECTIVE
This case provides data from serial assessments using a comprehensive neuropsychological test battery to assess the effects of severe toxicity on cognitive functioning, the pattern of deficits, and the regions of the brain that appear to be involved.


BACKGROUND
Lithium carbonate has made a significant contribution to the treatment of bipolar disorder, and considerable investigation has been conducted on both temporary and long-term side effects on the central nervous system. The effects of acute lithium intoxication on the central nervous system have been extensively documented.


METHODS
We studied a severe case of acute lithium intoxication and associated neuropsychological sequelae. The patient was evaluated twice with a comprehensive battery of neuropsychological tests within 2 years of the lithium intoxication.


RESULTS
Comprehensive neuropsychological evaluations indicated persistent cognitive sequelae, including impaired memory, attention, executive control functions, and visuospatial deficits.


CONCLUSIONS
The cognitive sequelae noted in the case of lithium toxicity are consistent with a subcortical dementia and the findings of other authors. Findings should be explored further in more rigorous clinical studies.
Brumm
V L
VL
Division of Neurology, Childrens Hospital Los Angeles, University of Southern California School of Medicine, 90027, USA.
van Gorp
W G
WG
Wirshing
W
W
D003071:Cognition / Q000187:drug effects*; D003704:Dementia / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008094:Lithium / Q000506:poisoning*; D008568:Memory / Q000187:drug effects; D008875:Middle Aged; D013028:Space Perception / Q000187:drug effects; D014796:Visual Perception / Q000187:drug effects
D008094:Lithium