title: Placental site trophoblastic tumor: molecular analysis and clinical experience.
abstract: Placental site trophoblastic tumor is a very rare variant of gestational trophoblastic disease which differs histologically and immunocytochemically from gestational choriocarcinoma. The English language literature includes only 74 reported cases. Seventeen patients have been managed at Charing Cross Hospital with this diagnosis. The median follow-up is 4.6 years, and the 5-year overall survival is 80% (95% confidence interval, 55-93%). Multivariate regression analysis identified an interval of >2 years since the preceding pregnancy as an independent adverse prognostic factor. Genotypic analysis by PCR allelotyping has confirmed the gestational origin of all 11 tumors successfully studied. More detailed molecular analysis has identified the causative pregnancy for eight tumors. Five were diploid biparental tumors following term pregnancies, and three were androgenetic tumors following monospermic complete hydatidiform moles.
authors.affiliation: Medical Oncology Unit, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, United Kingdom. rajn004@s1.cxws.ac.uk
authors.forename: M
authors.initials: M
authors.lastname: Bower
authors.forename: F J
authors.initials: FJ
authors.lastname: Paradinas
authors.forename: R A
authors.initials: RA
authors.lastname: Fisher
authors.forename: S K
authors.initials: SK
authors.lastname: Nicholson
authors.forename: G J
authors.initials: GJ
authors.lastname: Rustin
authors.forename: R H
authors.initials: RH
authors.lastname: Begent
authors.forename: K D
authors.initials: KD
authors.lastname: Bagshawe
authors.forename: E S
authors.initials: ES
authors.lastname: Newlands
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000097:blood; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D011379:Prognosis; D015996:Survival Rate; D016896:Treatment Outcome; D014328:Trophoblastic Neoplasms / Q000235:genetics* / Q000401:mortality / Q000628:therapy; D014594:Uterine Neoplasms / Q000235:genetics* / Q000401:mortality / Q000628:therapy
chemical_list: D006063:Chorionic Gonadotropin