Systemic administration of acidic fibroblast growth factor ameliorates the ischemic injury of the retina in rats.
The central neuroprotective effects against ischemic injury of fibroblast growth factor (FGF), administered either directly into the central nervous system or systemically, is well documented. Here we show in a rat model of transient retinal ischemia that the neuroprotective effect of systemically administered acidic fibroblast growth factor (aFGF, FGF-1) extends to the retina. Histological findings show a lower decrease of retinal ganglion cells and inner nuclear layer cells (P < 0.0001) in animals receiving FGF-1. These results suggest that FGF may function as a natural protection agent during transient retinal ischemia and further document that an efficient neuroprotection of central nervous tissues can be obtained by systemic administration of this protein. Our data may, thus, contribute to the development of novel and safe therapeutic approach for the treatment of the ischemic injury of the retina.
Cuevas
P
P
Departamento de Investigación, Hospital Ramón y Cajal, Madrid, Spain. pedro.cuevas@hrc.es
Carceller
F
F
Redondo-Horcajo
M
M
Lozano
R M
RM
Giménez-Gallego
G
G
D000818:Animals; D005260:Female; D016220:Fibroblast Growth Factor 1 / Q000008:administration & dosage* / Q000494:pharmacology; D006801:Humans; D007269:Injections, Intra-Arterial; D007511:Ischemia / Q000473:pathology*; D008297:Male; D018696:Neuroprotective Agents / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012171:Retinal Vessels / Q000187:drug effects* / Q000473:pathology
D018696:Neuroprotective Agents; D016220:Fibroblast Growth Factor 1