title: [Autonomic nervous function of the patients with neurally mediated syncope].
abstract: Although diagnosis of neurally mediated syncope (NMS) using head-up tilt (HUT) test has been established, the exact mechanism of NMS has not yet been elucidated. We evaluated beta and alpha-adrenergic function in NMS patients by pharmacological autonomic function test. The alpha-adrenergic sensitivity of NMS patients was significantly lower than that of control subjects. The patients who need low dose isoproterenol for provocation of syncope showed higher beta-adrenergic sensitivity than patients who developed syncope without isoproterenol. Thus, pharmacological autonomic function test was useful for evaluation of NMS patients.
authors.affiliation: 1st Department of Internal Medicine, Nippon Medical School, Tokyo.
authors.forename: H
authors.initials: H
authors.lastname: Saitoh
authors.forename: T
authors.initials: T
authors.lastname: Ono
authors.forename: A
authors.initials: A
authors.lastname: Nomura
authors.forename: Y
authors.initials: Y
authors.lastname: Iwasaki
authors.forename: N
authors.initials: N
authors.lastname: Ohno
authors.forename: S
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Y
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: H
authors.initials: H
authors.lastname: Atarashi
authors.forename: T
authors.initials: T
authors.lastname: Katoh
authors.forename: H
authors.initials: H
authors.lastname: Kishida
authors.forename: H
authors.initials: H
authors.lastname: Hayakawa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001341:Autonomic Nervous System / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007545:Isoproterenol; D008297:Male; D008722:Methods; D008875:Middle Aged; D011187:Posture; D019462:Syncope, Vasovagal / Q000503:physiopathology*
chemical_list: D007545:Isoproterenol