title: Advanced endocrine cell carcinoma of the gallbladder: a patient with 12-year survival.
abstract: Gallbladder carcinoid is a rare disease. In previous reports, classical carcinoid, an entity with a good prognosis, has not been distinguished from endocrine cell carcinoma, a tumor associated with marked cell atypia and mitosis, and a poor prognosis. The patient was a 66 year old woman who presented to our hospital with a chief complaint of jaundice. Pre-operatively, she was diagnosed as having advanced gallbladder carcinoma invading the liver and the hepatic hilus. The patient underwent right hepatic trisegmentectomy with en bloc resection of the caudate lobe and extrahepatic bile ducts, extended lymph node clearance and left hepaticojejunostomy. Histopathological examination showed positive Grimelius staining, marked mitosis, and intense atypism, hence, the tumor was diagnosed as an endocrine cell carcinoma. Twelve years after surgery, the patient is healthy, without any sign of recurrence. We present this novel case of long-term survival and review the literature.
authors.affiliation: Department of Surgery, Enshu General Hospital, Hamamatsu, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Mizukami
authors.forename: T
authors.initials: T
authors.lastname: Nagashima
authors.forename: K
authors.initials: K
authors.lastname: Ikuta
authors.forename: E
authors.initials: E
authors.lastname: Chikamatsu
authors.forename: K
authors.initials: K
authors.lastname: Kurachi
authors.forename: H
authors.initials: H
authors.lastname: Kanemoto
authors.forename: T
authors.initials: T
authors.lastname: Yagi
authors.forename: S
authors.initials: S
authors.lastname: Ohhira
authors.forename: Y
authors.initials: Y
authors.lastname: Nimura
mesh_terms: D000368:Aged; D002276:Carcinoid Tumor / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D005706:Gallbladder Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D006801:Humans