title: Schwangerschafts protein 1 (SP1) adds little to the age-related detection of fetal Down syndrome in the first trimester of pregnancy.
abstract: Schwangerschafts Protein 1 (SP1), being a placental protein appearing in the maternal circulation early in pregnancy, has been investigated as a potential marker for Down syndrome in the first trimester. Our study compared SP1 levels in 15 pregnancies with a Down syndrome fetus and 97 matched controls. Although the median MoM in Down syndrome pregnancies (0.49) was lower than in controls, its use as a marker added very little to the detection rate above the maternal age alone.
authors.affiliation: Groningen University Hospital, Department of Obstetrics and Gynaecology, The Netherlands.
authors.forename: L H
authors.initials: LH
authors.lastname: Kornman
authors.forename: L P
authors.initials: LP
authors.lastname: Morssink
authors.forename: K A
authors.initials: KA
authors.lastname: Ten Hoor
authors.forename: B T
authors.initials: BT
authors.lastname: De Wolf
authors.forename: M D
authors.initials: MD
authors.lastname: Kloosterman
authors.forename: J R
authors.initials: JR
authors.lastname: Beekhuis
authors.forename: A
authors.initials: A
authors.lastname: Mantingh
mesh_terms: D015415:Biomarkers / Q000097:blood*; D004314:Down Syndrome / Q000097:blood / Q000175:diagnosis*; D005260:Female; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000032:analysis*; D011296:Prenatal Diagnosis / Q000379:methods*; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D011268:Pregnancy-Specific beta 1-Glycoproteins