Effect of tropine derivatives, antimuscarinic agents, on the growth of Bombyx mori larvae.
A number of atropine analogs were synthesized and their effects on larval growth of the silkworm, Bombyx mori, were investigated by both topical application and dietary administration. Among the tested compounds, 8-methyl-8-azabicyclo[3.2.1]octan-3 alpha-ol 2,2-diphenylpropionate (5), an antagonist of the muscarinic acetylcholine receptor in mammals, significantly prolonged the duration of the instar. When fed on compound 5 at 30 ppm, some of the larvae failed to molt. A 2,2-diphenylpropionate moiety was indispensable for this activity. Compound 5 had more potent activity than atropine which is known to inhibit PTTH release in vitro.
Toyomura
N
N
Department of Agricultural Chemistry, Kyushu University, Fukuoka, Japan.
Kuwano
E
E
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001286:Atropine Derivatives; D001559:Benzhydryl Compounds / Q000494:pharmacology; D012831:Bombyx / Q000187:drug effects / Q000254:growth & development*; D007814:Larva / Q000187:drug effects; D018727:Muscarinic Antagonists / Q000494:pharmacology*; D014326:Tropanes / Q000494:pharmacology*
C116230:8-methyl-8-azabicyclo(3.2.1)octan-3-ol 2,2-diphenylpropionate; D001286:Atropine Derivatives; D001559:Benzhydryl Compounds; D018727:Muscarinic Antagonists; D014326:Tropanes; D001285:Atropine; C005864:tropine