Endotoxin temporarily impairs canine jejunal absorption of water, electrolytes, and glucose.
Enteral feeding during and after episodes of sepsis may be beneficial. The aim of our study was to determine the effects of a single sublethal dose of endotoxin on canine jejunal absorption. Following a 240 kcal liquid meal, absorption studies were performed in eight dogs with 75 cm jejunal Thiry-Vella fistulas. These fistulas were perfused with an isotonic solution containing polyethylene glycol to calculate absorption. Each dog was then given a single dose of Escherichia coli lipopolysaccharide, 200 microg/kg intravenously, and the studies were repeated for the next 3 days. Following endotoxin bolus infusion, net absorption of water, electrolytes, and glucose was decreased for 2 days and returned to baseline values on postendotoxin day 3. A single sublethal dose of endotoxin temporarily impairs canine jejunal absorption. Although enteral feeding may be advantageous, jejunal absorption may be temporarily impaired following an episode of endotoxemia.
Cullen
J J
JJ
Department of Surgery, University of Iowa College of Medicine and Veterans Affairs Medical Center, Iowa City, Iowa, USA.
Hemann
L L
LL
Ephgrave
K S
KS
Hinkhouse
M M
MM
D000818:Animals; D004285:Dogs; D004573:Electrolytes / Q000378:metabolism*; D019446:Endotoxemia / Q000378:metabolism; D004731:Endotoxins / Q000494:pharmacology*; D004926:Escherichia coli; D005947:Glucose / Q000378:metabolism*; D007408:Intestinal Absorption / Q000187:drug effects*; D007583:Jejunum / Q000378:metabolism*; D019518:Postprandial Period; D014867:Water / Q000378:metabolism*
D004573:Electrolytes; D004731:Endotoxins; D014867:Water; D005947:Glucose