Autosomal dominant carpal tunnel syndrome.
Carpal tunnel syndrome is common in adults and is usually sporadic and idiopathic. When carpal tunnel syndrome is inherited, it is often the manifestation of a systemic disease. We report carpal tunnel syndrome in an otherwise healthy woman aged 35 years. Family history reveals that her daughter, her sister and a sister's daughter, an aunt, a first cousin, her father and the paternal grandmother are also affected. The age of onset of the disease in this family was between 9 and 52 years of age. The family in this paper demonstrates an interesting pattern of inheritance with earlier onset of symptoms in subsequent generations, suggestive of anticipation.
Stoll
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C
Service de Génétique Médicale, CHU Strasbourg, France.
Maitrot
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D
D000293:Adolescent; D000328:Adult; D002349:Carpal Tunnel Syndrome / Q000150:complications / Q000235:genetics* / Q000473:pathology; D002648:Child; D005192:Family Health; D005260:Female; D005799:Genes, Dominant / Q000235:genetics*; D006225:Hand; D006801:Humans; D008297:Male; D008875:Middle Aged; D010292:Paresthesia / Q000209:etiology; D010375:Pedigree