Ultra-rapid opiate detoxification using deep sedation with oral midazolam: short and long-term results.
The present study describes an ultra-rapid opiate detoxification method using direct transition from heroin or methadone to oral naltrexone after deep sedation with oral midazolam in conjunction with ondansetron and clonidine treatment. Twenty patients were detoxified with the method. No serious events occurred, but two out of three patients vomited during the acute phase of deep sedation, which involves some risks. Withdrawal symptoms were still present 24 h after detoxification and 80% of the patients relapsed during a 6-month follow-up.
Cucchia
A T
AT
Département Universitaire de Psychiatrie Adulte, Site de Cery, Prilly-Lausanne, Switzerland.
Monnat
M
M
Spagnoli
J
J
Ferrero
F
F
Bertschy
G
G
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000768:Anesthesia, General; D003000:Clonidine / Q000008:administration & dosage / Q000009:adverse effects; D004359:Drug Therapy, Combination; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006556:Heroin Dependence / Q000534:rehabilitation*; D006801:Humans; D006993:Hypnotics and Sedatives; D007902:Length of Stay; D008297:Male; D008691:Methadone / Q000008:administration & dosage; D008874:Midazolam; D009271:Naltrexone / Q000008:administration & dosage / Q000009:adverse effects; D009292:Narcotic Antagonists / Q000008:administration & dosage / Q000009:adverse effects; D009460:Neurologic Examination / Q000187:drug effects; D017294:Ondansetron / Q000008:administration & dosage / Q000009:adverse effects; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis / Q000517:prevention & control; D016896:Treatment Outcome
D006993:Hypnotics and Sedatives; D009292:Narcotic Antagonists; D017294:Ondansetron; D009271:Naltrexone; D003000:Clonidine; D008874:Midazolam; D008691:Methadone