Susceptibility of penicillin-susceptible and -resistant pneumococci to CFC-222, a new fluoroquinolone.
The in-vitro activity of 12 antibacterial agents against 98 clinical isolates of Streptococcus pneumoniae, including 54 penicillin-resistant strains, was determined by a standardized broth microdilution method. CFC-222, vancomycin and imipenem were the most active agents, with an MIC90 of 0.5 mg/L for the test strains. CFC-222 was 16-fold more potent than ciprofloxacin and ofloxacin against all strains tested, including both penicillin-susceptible and -resistant strains. The anti-pneumococcal activity of fluoroquinolones was not affected by penicillin susceptibility. These results indicate that CFC-222 is potentially useful for treating infection caused by penicillin-resistant strains of S. pneumoniae.
Kim
J H
JH
Department of Microbial Chemistry, College of Pharmacy, Seoul National University, South Korea.
Kang
J A
JA
Lee
Y
Y
Lee
K H
KH
Lee
J H
JH
Choi
E C
EC
Kim
B K
BK
D000890:Anti-Infective Agents / Q000494:pharmacology*; D024841:Fluoroquinolones; D006801:Humans; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology*; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000302:isolation & purification
D000890:Anti-Infective Agents; C097672:CFC 222; D024841:Fluoroquinolones; D010406:Penicillins