Medical management of common bile duct stones.
Common bile duct stones are a common cause of morbidity and mortality in adults. An increasing number of surgical and medical therapies are available to manage them, with different success rates reported. The various medical treatment strategies were developed during the last decade, but these medical modalities should not be contemplated as a first-line alternative of treatment. A consensus from experts is that there is no primary indication to use solvents on common bile duct stones because they have a relatively high rate of adverse effects and their success is limited compared with lithotripsy. However, there is a subgroup of patients in whom invasive or surgical treatment is risky or may fail. In these patients stone dissolution by solvent may constitute a plausible therapeutic alternative or may help reduce the size of the stones sufficiently to facilitate subsequent endoscopic extraction. Solvents may also be indicated in settings where endoscopic techniques or lithotripsy are not available and the patient has a T-tube in the common bile duct. Even in this condition, however, it is probably quicker and more effective to refer the patient to a center with expertise and technologic support to practice stone removal.
González-Koch
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Department of Gastroenterology, Pontifica Universidad Católica de Chile, School of Medicine, Santiago, Chile.
Nervi
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D002210:Caprylates; D042882:Gallstones / Q000188:drug therapy*; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D005989:Glycerides / Q000627:therapeutic use*; D006801:Humans; D008738:Methyl Ethers / Q000627:therapeutic use; D012997:Solvents / Q000627:therapeutic use*; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use
D002210:Caprylates; D005765:Gastrointestinal Agents; D005989:Glycerides; D008738:Methyl Ethers; D012997:Solvents; C043243:methyl tert-butyl ether; D014580:Ursodeoxycholic Acid; C025343:monooctanoin