Necrobiosis lipoidica-like skin lesions in systemic sarcoidosis.
A 62-year-old woman with systemic sarcoidosis developed erythematous plaques on her lower legs. Clinically, two kinds of skin lesions were distinguished; one type formed brownish-red plaques with induration suggesting plaque-type skin sarcoid, and the other formed purplish erythematous plaques with atrophic centers resembling necrobiosis lipoidica. In spite of this clinical appearance, a biopsy specimen from one of the latter lesions revealed typical skin sarcoid histology composed of discrete non-caseating granulomas, while that from one of the other lesions showed necrobiotic changes of collagen bundles surrounded by epitheloid histiocytes and foreign-body giant cells. Because cutaneous involvement of sarcoidosis may mimic necrobiosis lipoidica clinically and/or histologically, we diagnosed her skin lesions as necrobiosis-like skin sarcoid.
Igawa
K
K
Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, Japan.
Maruyama
R
R
Satoh
T
T
Yokozeki
H
H
Katayama
I
I
Nishioka
K
K
D003094:Collagen; D003937:Diagnosis, Differential; D005260:Female; D015743:Giant Cells, Foreign-Body / Q000473:pathology; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D007868:Leg Dermatoses / Q000473:pathology; D008875:Middle Aged; D009335:Necrobiosis Lipoidica / Q000473:pathology*; D012507:Sarcoidosis / Q000473:pathology*; D012871:Skin Diseases / Q000473:pathology*
D003094:Collagen