[A four-box multi-function testing system of pharmacology reaction].
The organism position matrix method, a new method of testing pharmacology reaction is proposed. On the basis of the method, we have developed a four-box multi-function testing system which can test the spontaneous activity, analgesic effect, and learning and memory ability of 1 to 4 mice in three dimensions respectively. Four quantitative parameters, the total distance, the movement intensity, the vertical number and the jumping number are put forward to describe the spontaneous activity. The starting time of continuous jumping and the jumping number are used to describe the analgesic effect. The time from the electrical shock to escape onto a safety platform and the number of the electrical shock are used to describe the learning and memory ability. The system has the characteristics of good repeatability, high efficiency, quantitative and automatic control.
Wu
K
K
Dept. of Opto-electronic Precision Instruments, Chongqing University.
He
Z
Z
Xe
L
L
Guo
Y
Y
Yang
G
G
Zhou
C
C
Xiong
J
J
Yang
C
C
Xu
J
J
Deng
W
W
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004867:Equipment Design; D007858:Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects; D051379:Mice; D017288:Pain Threshold / Q000187:drug effects; D010600:Pharmacology / Q000295:instrumentation*