title: Duplex scanning and effect of multisegmental arterial disease on its accuracy in lower limb arteries.
abstract: OBJECTIVE
  To assess the accuracy of duplex in assessment of peripheral arterial disease and determine the effect of multisegmental disease on the accuracy duplex as opposed to single lesion.
  
  
  METHODS
  One hundred and seventy-seven lower limbs were examined in 90 patients who presented with lower limb arterial disease, (59 male, 31 female, median age 68 years--81 with intermittent claudication, eight rest pain, one ulceration). Patients were examined with duplex US, and arteriography (IA DSA). Two radiologists and two technologists were involved in this double-blind study. Patients were classified into five groups; groups with single stenotic lesions, single occlusions, multiple stenotic lesions or occlusions, and multiple mixed disease. Duplex accuracy was determined in each group.
  
  
  RESULTS
  Duplex was able to differentiate between normal and disease arterial segment with a sensitivity of 92%, specificity 99%, PPV 91%, and NPV 100% and Kappa 0.87. Sixty-six limbs were found to have single lesions, and 68 multisegmental disease. Duplex showed accuracy with a sensitivity of 87%, and specificity of 99%, for single stenotic lesion and 95%, 96% respectively for multisegmental. For single occlusions duplex accuracy showed sensitivity 92% and specificity 100%, and for multisegmental occlusions, sensitivity 97%, and specificity 99%. For mixed multisegmental pathology (stenosis and occlusion), sensitivity 94% and specificity 97%.
  
  
  CONCLUSIONS
  Duplex is an accurate tool in diagnosis of lower limb arterial disease and multisegmental pathology does not adversely effect this accuracy.
authors.affiliation: Department of Surgery, University College London and Medical School, UK.
authors.forename: S
authors.initials: S
authors.lastname: Aly
authors.forename: M P
authors.initials: MP
authors.lastname: Jenkins
authors.forename: F H
authors.initials: FH
authors.lastname: Zaidi
authors.forename: P D
authors.initials: PD
authors.lastname: Coleridge Smith
authors.forename: C C
authors.initials: CC
authors.lastname: Bishop
mesh_terms: D000368:Aged; D015901:Angiography, Digital Subtraction; D016022:Case-Control Studies; D004311:Double-Blind Method; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007383:Intermittent Claudication / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D016491:Peripheral Vascular Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D012680:Sensitivity and Specificity; D018616:Ultrasonography, Doppler, Duplex