title: Genotoxicity from domestic use of organophosphate pesticides.
abstract: This report describes the types of chromosome damage in peripheral blood found in patients exposed to domestic application of organophosphate pesticides. These changes serve as a biomarker of cumulative toxic exposure. Susceptible individuals show DNA damage as chromosome alterations. The importance of these findings is that the apparent genotoxic changes occurred from domestic application of two of the commonly used organophosphate pesticides in America and adds one more adverse potential effect from these hazardous chemicals. Peripheral blood from eight patients exposed to the domestic spraying of organophosphate pesticides was cultured and the chromosomes photographed. The types of chromosome alterations seen included chromatid and chromosome breaks, single and double minutes, dicentrics, rings, translocations, exchanges (including sister chromatid), and endoreduplications. Our findings support previous findings that organophosphate pesticides have genotoxic effects even at domestically sprayed levels.
authors.affiliation: Center for Occupational and Environmental Medicine, North Charleston, South Carolina 29420, USA.
authors.forename: A D
authors.initials: AD
authors.lastname: Lieberman
authors.forename: M R
authors.initials: MR
authors.lastname: Craven
authors.forename: H A
authors.initials: HA
authors.lastname: Lewis
authors.forename: J H
authors.initials: JH
authors.lastname: Nemenzo
mesh_terms: D000061:Accidents, Home; D000328:Adult; D002648:Child; D002869:Chromosome Aberrations; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D005796:Genes / Q000187:drug effects*; D006801:Humans; D007306:Insecticides / Q000009:adverse effects*; D008297:Male; D008677:Metaphase / Q000187:drug effects; D008875:Middle Aged; D009943:Organophosphorus Compounds; D012854:Sister Chromatid Exchange / Q000187:drug effects; D013997:Time Factors
chemical_list: D007306:Insecticides; D009943:Organophosphorus Compounds