title: Endogenous retroviruses and multiple sclerosis. II. HERV-7q.
abstract: The search for new endogenous retroviral sequences, on the basis of sequence homologies with the pol gene of the recently reported multiple sclerosis associated retrovirus (MSRV), allowed us to identify a full length endogenous retrovirus sequence located on the long arm of human chromosome 7. This retrovirus, HERV-7q, includes in its env region, within a single 1,620 bp open reading frame, a 664 bp domain almost identical to a 3' non-coding region of the rab7 gene. Transcripts encompassing both the env and the 3' LTR regions of HERV-7q have already been identified as expressed sequence tags, suggesting that this env-like gene might code for a 538 amino acid long deduced protein.
authors.affiliation: Inserm, Paris, France.
authors.forename: P M
authors.initials: PM
authors.lastname: Alliel
authors.forename: J P
authors.initials: JP
authors.lastname: Périn
authors.forename: R
authors.initials: R
authors.lastname: Pierig
authors.forename: J L
authors.initials: JL
authors.lastname: Nussbaum
authors.forename: A
authors.initials: A
authors.lastname: Ménard
authors.forename: F
authors.initials: F
authors.lastname: Rieger
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D002897:Chromosomes, Human, Pair 7; D020077:Endogenous Retroviruses / Q000235:genetics*; D015752:Genes, env; D006801:Humans; D008969:Molecular Sequence Data; D009103:Multiple Sclerosis / Q000821:virology*; D016366:Open Reading Frames; D017386:Sequence Homology, Amino Acid