[Long-term monotherapy with prestarium, anap and lomir in patients with mild and moderate arterial hypertension: clinical efficacy, hemodynamics and morphofunctional parameters of heart].
OBJECTIVE
To assess effectiveness of blood hypertension treatment with inhibitors of angiotensin converting enzyme and calcium channels blocker.


METHODS
83 outpatients with mild and moderate blood hypertension received monotherapy with prestarium, anap and lomir for 12 months. The trends in parameters of blood pressure, total peripheral vascular resistance, thickness of the interventricular septum and left ventricular posterior wall were estimated.


RESULTS
Long-term effective monotherapy with prestarium, anap and lomir was possible in 47, 62 and 45% of the patients, respectively. Diastolic pressure lowered by 25, 24 and 25%, total peripheral vascular resistance reduced by 20, 19 and 22%, respectively. The three drugs produced similar positive effects on left ventricular thickness, had no negative effects on bioelectric activity of the heart, clinical and biochemical blood counts.


CONCLUSIONS
Prestarium, anap and lomir are effective against hypertension and diminish left ventricular hypertrophy in hypertensive patients.
Nesterov
Iu I
IuI
Gol'dberg
G A
GA
D000328:Adult; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D001386:Azides / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004452:Echocardiography; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D007211:Indoles / Q000627:therapeutic use*; D017275:Isradipine / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D020913:Perindopril; D016896:Treatment Outcome; D014655:Vascular Resistance / Q000187:drug effects
D000806:Angiotensin-Converting Enzyme Inhibitors; D001386:Azides; D002121:Calcium Channel Blockers; D007211:Indoles; D016308:Enkephalin, Leucine-2-Alanine; C041849:enkephalinamide-Leu, Ala(2)-N-(2-((4-azido-2-nitrophenyl)amino)N-ethyl(5))-; D020913:Perindopril; D017275:Isradipine
Dlitel'naia monoterapiia prestariumom, énapom i lomirom u bol'nykh miagkoĭ i umerennoĭ arterial'noĭ gipertonieĭ: klinicheskaia éffektivnost', gemodinamika i morfofunktsional'nye pokazateli serdta.