Effect of amantadine on sexual dysfunction in neuroleptic-treated male schizophrenic patients.
Twelve male schizophrenic outpatients treated with neuroleptics took part in an open-label drug study to assess the impact of co-administration of amantadine hydrochloride (100 mg daily for 6 weeks) on sexual function. Amantadine improved the patients' scores in three out of four areas of sexual function: desire (p < 0.02), erection (p < 0.05), and satisfaction from sexual performance (p < 0.05); there was no change in ejaculatory function. Amantadine may be effective for improving sexual function in male schizophrenic patients receiving neuroleptic medication.
Valevski
A
A
Geha Psychiatric Hospital, Rabin Medical Center, Petah Tiqva, Israel.
Modai
I
I
Zbarski
E
E
Zemishlany
Z
Z
Weizman
A
A
D000328:Adult; D000547:Amantadine / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D015259:Dopamine Agents / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000150:complications* / Q000188:drug therapy; D020018:Sexual Dysfunctions, Psychological / Q000139:chemically induced / Q000188:drug therapy* / Q000209:etiology
D014150:Antipsychotic Agents; D015259:Dopamine Agents; D000547:Amantadine