title: Presence of Epstein-Barr virus in lymphoepithelioma-like carcinoma of the middle ear.
abstract: OBJECTIVE
  To examine the association of Epstein-Barr virus (EBV) with carcinoma of the ear.
  
  
  METHODS
  Five non-keratinising squamous cell carcinomas and two undifferentiated carcinomas of the ear were examined. In situ hybridisation was used to localised EBV-encoded RNAs (EBER). Immunohistochemical methods to detect LMP-1 and EBNA2 were performed in the EBER positive cases.
  
  
  RESULTS
  Two cases were EBER positive, including one non-keratinising and one undifferentiated carcinoma. Both showed identical morphology to those arising from the nasopharynx, with abundant lymphoid stroma. They were both negative for LMP-1 and EBNA2.
  
  
  CONCLUSIONS
  EBV associated carcinoma with the morphology of lymphoepithelioma can also arise from the middle ear.
authors.affiliation: Department of Pathology, University of Hong Kong, Queen Mary Hospital, Hong Kong.
authors.forename: S Y
authors.initials: SY
authors.lastname: Leung
authors.forename: S T
authors.initials: ST
authors.lastname: Yuen
authors.forename: C M
authors.initials: CM
authors.lastname: Ho
authors.forename: W K
authors.initials: WK
authors.lastname: Kwong
authors.forename: L P
authors.initials: LP
authors.lastname: Chung
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000473:pathology / Q000821:virology*; D004428:Ear Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000821:virology*; D004432:Ear, Middle; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D017403:In Situ Hybridization; D008297:Male; D014057:Tomography, X-Ray Computed