Cerebrospinal fluid levels of alpha-tocopherol in amyotrophic lateral sclerosis.
We compared CSF and serum levels, and the CSF/serum ratio of alpha-tocopherol (vitamin E), measured by HPLC, in 30 patients with sporadic amyotrophic lateral sclerosis (SALS) and 78 matched controls. The mean CSF and serum vitamin E levels did not differ significantly between the 2 study groups. These values were not influenced by the clinical form (spinal versus bulbar) of SALS. CSF alpha-tocopherol levels did not correlate with age, age at onset, and duration of the disease. These results suggest that CSF and serum alpha-tocopherol concentrations are unrelated with the risk for ALS.
de Bustos
F
F
Department of Biochemistry, Hospital Universitario Doce de Octubre, Madrid, Spain.
Jiménez-Jiménez
F J
FJ
Molina
J A
JA
Esteban
J
J
Guerrero-Sola
A
A
Zurdo
M
M
Ortí-Pareja
M
M
Tallón-Barranco
A
A
Gómez-Escalonilla
C
C
Ramírez-Ramos
C
C
Arenas
J
J
Enríquez de Salamanca
R
R
D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D008161:Lumbosacral Region; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D014810:Vitamin E / Q000097:blood / Q000134:cerebrospinal fluid*
D014810:Vitamin E