title: The role of membrane structure in the activation of mitochondrial phospholipases. 1. Activation of mitochondrial phospholipases by lipid peroxidation products.
abstract: Induction of lipid peroxidation is shown to alter the structure of mitochondrial membrane and to activate endogenous phospholipases A2, C, D, and lysophospholipase A. Fe(2+)-, cumene hydroperoxide- and ultraviolet-induced lipid peroxidation results in the activation of mitochondrial phospholipases.
authors.affiliation: Tashkent State University, Biological Faculty, Department of Biophysics, Republic of Uzbekistan.
authors.forename: Y T
authors.initials: YT
authors.lastname: Timusheva
authors.forename: O A
authors.initials: OA
authors.lastname: Mareninova
authors.forename: O N
authors.initials: ON
authors.lastname: Vagina
authors.forename: M V
authors.initials: MV
authors.lastname: Zamaraeva
authors.forename: B A
authors.initials: BA
authors.lastname: Salakhutdinov
authors.forename: T F
authors.initials: TF
authors.lastname: Aripov
authors.forename: B A
authors.initials: BA
authors.lastname: Tashmukhamedov
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D001555:Benzene Derivatives / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D004578:Electron Spin Resonance Spectroscopy; D004789:Enzyme Activation; D007425:Intracellular Membranes / Q000187:drug effects / Q000201:enzymology* / Q000528:radiation effects; D007527:Isoenzymes / Q000378:metabolism; D015227:Lipid Peroxidation; D008563:Membrane Lipids / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology* / Q000528:radiation effects; D016877:Oxidants / Q000494:pharmacology; D010740:Phospholipases / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D014466:Ultraviolet Rays
chemical_list: D001555:Benzene Derivatives; D007527:Isoenzymes; D008563:Membrane Lipids; D008565:Membrane Proteins; D016877:Oxidants; D010743:Phospholipids; D010740:Phospholipases; C007164:cumene hydroperoxide; D001205:Ascorbic Acid; D002118:Calcium