[Physiological analysis of stress-induced changes in the suppressor activity of mouse T-lymphocytes].
Suppressor activity of the T-lymphocytes was studied by means of evaluating the alterations in humoral immune response in the system of adoptive transfer of splenocytes from immunised donors (PFC/106 splenocytes) in mice. Administration of glucocorticoids or stress prior to the immunisation decreased the suppressor activity of the T-lymphocytes and enhanced humoral immune response. In adrenalectomised mice, absence of glucocorticoid hormones in the blood did not prevent normal development of the suppressor functions of the T-lymphocytes. Administration of Interleukin-1 prior to the stress or hydrocortisone administration normalised the T-lymphocytes' functions.
Fomicheva
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EE
Institute of Experimental Medicine of the Russian Acad. Sci., St. Petersburg, Russia.
Rybakina
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EG
D000315:Adrenalectomy; D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D005938:Glucocorticoids / Q000097:blood / Q000494:pharmacology; D007165:Immunosuppression Therapy; D007375:Interleukin-1 / Q000097:blood / Q000494:pharmacology; D008297:Male; D051379:Mice; D012756:Sheep; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013312:Stress, Physiological / Q000097:blood / Q000276:immunology*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
D005938:Glucocorticoids; D007375:Interleukin-1
Fiziologicheskiĭ analiz stressindutsirovannogo izmeneniia supressornoĭ aktivnosti T-limfotsitov u mysheĭ.