Effect of triiodothyronine administration on the recovery of liver oxidative capacity after partial hepatectomy.
The aim of the present work was to investigate the role of triiodothyronine on liver regeneration after partial hepatectomy in the rat. During the first 3 days of liver regeneration, total protein, total DNA content and total cytochrome c oxidase activity of the residual tissue increased from 30% immediately after partial hepatectomy to 70% of the preoperative values in control rats. In triiodothyronine-treated rats, the increase in total protein was the same (70%), however, the increase in total liver DNA content and total cytochrome c oxidase acitivity was 100 and 135%, respectively during the first 3 days of regeneration. Triiodothyronine administration also increased significantly the activity of mitochondrial ATPase in regenerating liver.
Cervinková
Z
Z
Department of Physiology, Faculty of Medicine, Charles University, Hradec Králové, Prague, Czech Republic. wolff@lfhk.cuni.cz
Svátková
R
R
Kalous
M
M
Rauchová
H
H
Cervinka
M
M
Drahota
Z
Z
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D004247:DNA / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000378:metabolism; D006498:Hepatectomy; D007700:Kinetics; D008099:Liver / Q000187:drug effects* / Q000378:metabolism*; D008115:Liver Regeneration / Q000187:drug effects* / Q000502:physiology*; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology; D010084:Oxidation-Reduction; D011506:Proteins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014284:Triiodothyronine / Q000494:pharmacology*
D011506:Proteins; D014284:Triiodothyronine; D004247:DNA; D003576:Electron Transport Complex IV; D000251:Adenosine Triphosphatases