Effects of neurotropin on hyperalgesia and allodynia in mononeuropathic rats.
Neurotropin is commonly used in Japan for the treatment of chronic pain. Using a rat model, we evaluated the effect of neurotropin on a unilateral peripheral mononeuropathy produced by placing loose ligatures around the sciatic nerve. The effect of neurotropin upon the resultant hyperalgesia and mechanical allodynia was assessed using the Ugo Basile Plantar test and von Frey hairs test, respectively. Neurotropin reduced thermal hyperalgesia and produced an early recovery from hyperalgesia in a dose-dependent manner. No significant reduction in mechanical allodynia, however, was noted under the tested condition. A possibility of differential drug sensitivity for thermal hyperalgesia and mechanical allodynia was indicated in this model, although the reason still remain elusive.
Saleh
M R
MR
Department of Orthopedic Surgery, Hiroshima University School of Medicine, Japan.
Muneshige
H
H
Ikuta
Y
Y
D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006358:Hot Temperature; D006930:Hyperalgesia / Q000188:drug therapy*; D008026:Ligation; D008297:Male; D009409:Nerve Crush; D010146:Pain / Q000188:drug therapy*; D017288:Pain Threshold / Q000187:drug effects / Q000502:physiology; D011134:Polysaccharides / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000293:injuries / Q000503:physiopathology
D000700:Analgesics; D011134:Polysaccharides; C010491:neurotropin