title: Amplification of int-2 and bcl-1 genes in squamous cell carcinoma of the larynx.
abstract: We studied int-2 and bcl-1 gene amplification in 21 operated patients with cancer of the larynx. In 9 cases, the int-2 gene was amplified (42.9%) and in 4 cases. the bcl-1 gene was amplified (25.0%). Co-amplification of int-2 and bcl-1 was observed in three cases (18.8%), all of which were glottic carcinomas. Other amplified cases were supraglottic carcinomas. Tumor specimens with int-2 amplification were associated with a significantly worse prognosis. We suggest that int-2 amplification is one of the prognostic factors in laryngectomized patients with cancer of the larynx.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Nara Medical University, Kashihara, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Miyahara
authors.forename: H
authors.initials: H
authors.lastname: Naito
authors.forename: K
authors.initials: K
authors.lastname: Ueda
authors.forename: K
authors.initials: K
authors.lastname: Yane
authors.forename: T
authors.initials: T
authors.lastname: Matsunaga
authors.forename: K
authors.initials: K
authors.lastname: Okaichi
authors.forename: T
authors.initials: T
authors.lastname: Ohnishi
mesh_terms: D000328:Adult; D000368:Aged; D015139:Blotting, Southern / Q000379:methods; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D005784:Gene Amplification / Q000235:genetics*; D019940:Genes, bcl-1 / Q000235:genetics*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009693:Nucleic Acid Hybridization / Q000379:methods; D009857:Oncogenes / Q000235:genetics*; D011379:Prognosis
chemical_list: D004273:DNA, Neoplasm