title: Fatal enterovirus 71 encephalomyelitis.
abstract: During an outbreak of hand-foot-mouth disease caused by enterovirus 71 (EV-71) in 1997, 4 children presented with sudden cardiopulmonary collapse and minimal neurologic features. All children received cardiopulmonary resuscitation but died within a few hours of admission. Postmortem studies showed infection by EV-71 with extensive damage to the medulla and pons. We postulate an etiologic link between EV-71 and brainstem encephalomyelitis as the cause of pulmonary edema and death.
authors.affiliation: Department of Pediatrics, the Department of Pathology, the Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: L C
authors.initials: LC
authors.lastname: Lum
authors.forename: K T
authors.initials: KT
authors.lastname: Wong
authors.forename: S K
authors.initials: SK
authors.lastname: Lam
authors.forename: K B
authors.initials: KB
authors.lastname: Chua
authors.forename: A Y
authors.initials: AY
authors.lastname: Goh
authors.forename: W L
authors.initials: WL
authors.lastname: Lim
authors.forename: B B
authors.initials: BB
authors.lastname: Ong
authors.forename: G
authors.initials: G
authors.lastname: Paul
authors.forename: S
authors.initials: S
authors.lastname: AbuBakar
authors.forename: M
authors.initials: M
authors.lastname: Lambert
mesh_terms: D002675:Child, Preschool; D004679:Encephalomyelitis / Q000473:pathology / Q000821:virology*; D004769:Enterovirus Infections / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008526:Medulla Oblongata / Q000473:pathology; D011654:Pulmonary Edema / Q000821:virology