L-proline as a nitrogen source increases the susceptibility of Saccharomyces cerevisiae S288c to fluconazole.
Fluconazole inhibition of Saccharomyces cerevisiae S288c growth was evaluated in media containing ammonia, L-proline or L-leucine as a nitrogen source. Growth inhibition by fluconazole was maximum when L-proline was used as a nitrogen source, while rhodamine 6G accumulation and fluconazole resistance were the highest when ammonia was the sole nitrogen source.
Stella
C A
CA
Biochemistry Department, School of Medicine, Buenos Aires University, Argentina.
Costanzo
R
R
Burgos
H I
HI
Saenz
D A
DA
Venerus
R D
RD
D000935:Antifungal Agents / Q000494:pharmacology*; D003470:Culture Media; D004352:Drug Resistance, Microbial; D015725:Fluconazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009584:Nitrogen / Q000378:metabolism*; D011392:Proline / Q000378:metabolism*; D012235:Rhodamines / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000254:growth & development
D000935:Antifungal Agents; D003470:Culture Media; D012235:Rhodamines; D015725:Fluconazole; D011392:Proline; D009584:Nitrogen