[Prostasomes enhance sperm capacity. Prostatic components, or antibodies against them, may be used in in vitro fertilization, as contraceptive agents and for the diagnosis of cancer].
The article consists in a report of the prostasomes, which are secreted into the gland ducts of the human prostate. At ejaculation, these native prostasomes are expelled with prostate secretions and are to be found in the seminal plasma as seminal prostasomes which facilitate sperm function in various ways. The authors have designed methods for producing monoclonal anti-prostasome antibodies for use in immunohistochemistry, in sequencing analysis of the prostasomes, and in the immunostaining of prostate carcinoma metastases.
Ronquist
G
G
Klinisk kemi, Centrum för laboratoriemedicin, Akademiska sjukhuset, Uppsala.
Nilsson
B O
BO
D000906:Antibodies; D003271:Contraceptive Agents, Female; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D015388:Organelles / Q000276:immunology / Q000378:metabolism / Q000648:ultrastructure; D011467:Prostate / Q000166:cytology / Q000378:metabolism / Q000648:ultrastructure; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000276:immunology / Q000648:ultrastructure; D013075:Sperm Capacitation; D013081:Sperm Motility
D000906:Antibodies; D003271:Contraceptive Agents, Female
Prostasomer ökar spermiers förmåga. Prostatakomponenter, eller antikroppar mot dem, kan komma att användas vid provrörsbefruktning, som preventivmedel och för diagnostik av cancer.