Contact allergy to the monomers of p-tert-butylphenol-formaldehyde resin in the guinea pig.
In patients hypersensitive to p-tert-butylphenol-formaldehyde resin (PTBP-F-R), and butylphenol derivatives therein, it is for diagnostic, therapeutic and preventive reasons necessary to know the identity of the primary sensitizing substances, their sensitizing capacities as well as their cross-reaction patterns. The monomers in PTBP-F-R, 2-methylol p-tert-butylphenol (2-MPTBP) and 2,6-dimethylol p-tert-butylphenol (2,6-MPTBP), have been shown to be contact sensitizers in man. The aim of this study was to investigate the sensitizing capacities of the monomers and establish cross-reacting patterns in the guinea pig with the guinea pig maximization test. 2,6-MPTBP was shown to be a strong sensitizer while it was indicated that 2-MPTBP was a sensitizer. Animals sensitized to 2,6-MPTBP showed cross-reactions to 2-MPTBP and p-tert-butylcatechol. No cross-reactions were shown to p-tert-butylphenol, tert-butyl 4-hydroxyanisole (BHA) and 3,5-di-tert-butyl 4-hydroxytoluene (BHT).
Zimerson
E
E
Department of Occupational and Environmental Dermatology, University Hospital Malmö, Sweden.
Bruze
M
M
D000818:Animals; D002083:Butylated Hydroxyanisole / Q000009:adverse effects; D002084:Butylated Hydroxytoluene / Q000009:adverse effects / Q000031:analogs & derivatives; D002851:Chromatography, High Pressure Liquid; D003429:Cross Reactions; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D005260:Female; D006168:Guinea Pigs; D007428:Intradermal Tests; D010636:Phenols / Q000009:adverse effects; D012117:Resins, Synthetic / Q000009:adverse effects*
D010636:Phenols; D012117:Resins, Synthetic; D002084:Butylated Hydroxytoluene; D002083:Butylated Hydroxyanisole; C014273:p-tert-butylphenolformaldehyde resin; C037667:3,5-di-tert-butyl-4-hydroxytoluene; C006862:butylphen