Rosai-Dorfman disease (extranodal sinus histiocytosis) in a patient with HIV.
Rosai-Dorfman disease, or sinus histiocytosis with massive lymphadenopathy (SHML), is a rare histiocytosis of unknown etiology that most commonly involves the cervical lymph nodes. Extranodal involvement occurs in 30-40% of cases, most often in the head and neck. Characteristic histologic findings include emperiopolesis (engulfment) of lymphocytes and S-100 protein positivity. Treatment of Rosai-Dorfman disease is unnecessary unless the disorder becomes life- or organ-threatening, since the disease will resolve spontaneously in most patients. We present what, to the best of our knowledge, is the first reported case of Rosai-Dorfman disease limited to the skin in a patient infected with human immunodeficiency virus. SHML is described and diagnostic and therapeutic measures are reviewed.
Perry
B P
BP
Division of Otolaryngology-Head and Neck Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Gregg
C M
CM
Myers
S
S
Lilly
S
S
Mann
K P
KP
Prieto
V
V
D000328:Adult; D006679:HIV Seropositivity / Q000150:complications*; D015618:Histiocytosis, Sinus / Q000150:complications* / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D008297:Male; D009296:Nasal Cavity / Q000473:pathology / Q000601:surgery