title: Soluble L-selectin plasma concentrations in infants undergoing heart surgery: no association with capillary leak syndrome or need for respiratory support.
abstract: OBJECTIVE
  In critical care patients at risk of developing the acute respiratory distress syndrome (ARDS), low soluble L-selectin (sCD62L) plasma concentrations have been shown to be associated with progression to ARDS and prolonged subsequent mechanical ventilation. This study aimed to determine the usefulness of sCD62L plasma concentrations to identify infants undergoing cardiovascular surgery who are at risk for postoperative pulmonary dysfunction and capillary leaks.
  
  
  METHODS
  Serial measurements of sCD62L plasma concentrations in a cohort of infants with congenital heart disease before, during, and after surgery for 4 consecutive days.
  
  
  METHODS
  Infants aged 3-337 days undergoing cardiovascular surgery with (N = 27) or without (N = 12) cardiopulmonary bypass in a tertiary care center.
  
  
  RESULTS
  sCD62L concentrations before surgery showed a strong correlation with the infant's age (r = 0.77, p < 0.001). During surgery, sCD62L levels dropped from 9.0 +/- 0.7 to 5.6 +/- 0.4 nmol/l (mean +/- SEM; p < 0.001). The minimum sCD62L concentration during and after surgery did not differ between infants operated upon with or without cardiopulmonary bypass (p > 0.1) or in infants who did (N = 10) or did not (N = 29) develop capillary leak syndrome. Whereas capillary leak syndrome was associated with prolonged mechanical ventilation (p < 0.01), there was no relationship between sCD62L concentrations at baseline or at any time thereafter and number of hours on the ventilator(p > 0.1).
  
  
  CONCLUSIONS
  sCD62L concentrations before or after surgery are not apt to identify infants at increased risk of prolonged mechanical ventilation.
authors.affiliation: Department of Congenital Heart Disease/Pediatric Cardiology, German Heart Institute, Berlin. christoph.buehrer@charite.de
authors.forename: C
authors.initials: C
authors.lastname: Bührer
authors.forename: B
authors.initials: B
authors.lastname: Stiller
authors.forename: V
authors.initials: V
authors.lastname: Alexi-Meskishvili
authors.forename: R
authors.initials: R
authors.lastname: Hetzer
authors.forename: P E
authors.initials: PE
authors.lastname: Lange
mesh_terms: D000367:Age Factors; D019559:Capillary Leak Syndrome / Q000209:etiology*; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D002315:Cardiopulmonary Bypass / Q000009:adverse effects; D006330:Heart Defects, Congenital / Q000097:blood* / Q000601:surgery*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D019041:L-Selectin / Q000097:blood*; D011446:Prospective Studies; D012121:Respiration, Artificial / Q000009:adverse effects; D012128:Respiratory Distress Syndrome / Q000209:etiology*; D012307:Risk Factors
chemical_list: D019041:L-Selectin