title: [Toxic epidermal necrolysis after treatment with lamotrigine].
abstract: A case of toxic epidermal necrolysis following treatment with lamotrigine is presented. A 20 year old male suffering from epilepsy was treated with lamotrigine in addition to valproic acid. After three weeks he developed cutaneous manifestations of Steven-Johnson's syndrome followed by toxic epidermal necrolysis, mucosal lesions and liver symptoms. He was treated with systemic corticosteroids, antibiotics and intravenous fluid, and recovered after a few weeks.
authors.affiliation: Dermatologisk afdeling, Bispebjerg Hospital, København.
authors.forename: C O
authors.initials: CO
authors.lastname: Zachariae
authors.forename: K
authors.initials: K
authors.lastname: Fogh
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D004827:Epilepsy / Q000188:drug therapy*; D006801:Humans; D000077213:Lamotrigine; D008297:Male; D013262:Stevens-Johnson Syndrome / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D014227:Triazines / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000927:Anticonvulsants; D014227:Triazines; D000077213:Lamotrigine
vernacular_title: Toksisk epidermal nekrolyse efter lamotriginbehandling.