Anterior pituitary development and Pit-1/GHF-1 transcription factor.
Anterior pituitary differentiation is a well-established paradigm in mammalian organogenesis. PIT1/GHF1, a homoeotic gene, plays a key role in terminal pituitary differentiation. Recently, a new set of transcription factors involved in early pituitary differentiation have been identified: Lhx-3, Lhx-4, P-OTX and Prop1. A pituitary-specific transcriptional cascade regulating a developmental programme leads to the determination of the mature cell types.
de la Hoya
M
M
Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Universidad Autónoma de Madrid, Spain.
Vila
V
V
Jiménez
O
O
Castrillo
J L
JL
D000818:Animals; D004268:DNA-Binding Proteins / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins / Q000502:physiology; D006801:Humans; D010902:Pituitary Gland / Q000196:embryology* / Q000502:physiology*; D050817:Transcription Factor Pit-1; D014157:Transcription Factors / Q000502:physiology*
D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; C494187:POU1F1 protein, human; D050817:Transcription Factor Pit-1; D014157:Transcription Factors