title: 1,25(OH)2 vitamin D3 binding sites in male sex organs of the Siberian hamster (Phodopus sungorus). An autoradiographic study.
abstract: Using autoradiography, binding sites for 1,25(OH)2 vitamin D3 are found in certain genital organs of male Siberian hamsters (Phodopus sungorus), in particular in basal epithelial cells and fibroblasts of the lamina propria of prostate glands. Scattered labeled cells are also present in the epithelium of coagulation and urethral glands. In contrast to the findings in mice, under the conditions of the experiment, 1,25(OH)2 vitamin D3 binding sites are not recognizable in other accessory sex glands and gonads. The frequency of basal epithelial cells with [3H]1,25(OH)2 vitamin D3 nuclear binding is higher in regressed dorsal prostate glands of animals living in short photoperiods. The data suggest that 1,25(OH)2 vitamin D3 may promote proliferation and differentiation in basal epithelial cells, modulated by the seasonal and functional status of the animal.
authors.affiliation: Universität (GHS) Essen, Abteilung für Pädiatrische Endokrinologie, Zentrum für Kinder- und Jugendmedizin, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Schleicher
authors.forename: A
authors.initials: A
authors.lastname: Bartke
authors.forename: H J
authors.initials: HJ
authors.lastname: Bidmon
authors.forename: W E
authors.initials: WE
authors.lastname: Stumpf
mesh_terms: D000818:Animals; D001345:Autoradiography; D001665:Binding Sites / Q000502:physiology*; D002117:Calcitriol / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism; D006224:Cricetinae; D005837:Genitalia, Male / Q000166:cytology*; D006066:Gonads / Q000166:cytology; D006651:Histocytochemistry; D008297:Male; D017111:Phodopus; D011467:Prostate / Q000166:cytology
chemical_list: D002117:Calcitriol