title: Effects of recruitment of collapsed lung units on the elastic pressure-volume relationship in anaesthetised healthy adults.
abstract: BACKGROUND
  The elastic pressure-volume (Pel-V) curve of the respiratory system can be used as a guide for improved ventilator management. The understanding of curves recorded for sick patients can be improved with better knowledge of the Pel-V relationship observed in healthy humans. Dynamic Pel-V curves were determined over an extended volume range in 15 anaesthetised and muscle-relaxed healthy humans. The influence of a recruitment manoeuvre was studied.
  
  
  METHODS
  Dynamic Pel-V curves were determined during a single prolonged insufflation before and after the recruitment manoeuvre. A mathematical three-segment model of the curve including a linear intermediate segment, delineated by the lower (LIP) and upper (UIP) inflection points, was used for characterisation of the recorded curves.
  
  
  RESULTS
  The model gave an adequate description of the recorded Pel-V curves. Before the recruitment manoeuvre, compliance increased until the LIP was reached at 20 cm H2O (1.9 L). Then followed a long linear segment. After the recruitment manoeuvre, compliance increased during insufflation until a LIP was reached at 13 cm H2O (1.2 L). Above the LIP followed a shorter linear segment (compliance = 140 mL/cm H2O) and then an upper segment with decreasing compliance.
  
  
  CONCLUSIONS
  Pel-V curves recorded before and after the recruitment manoeuvre show that large lung compartments close during anaesthesia and that high pressures are needed to achieve recruitment even in the normal lung. Accordingly, the LIP does not define the end of recruitment during insufflation.
authors.affiliation: Department of Clinical Physiology, Lund University Hospital, Sweden.
authors.forename: C
authors.initials: C
authors.lastname: Svantesson
authors.forename: S
authors.initials: S
authors.lastname: Sigurdsson
authors.forename: A
authors.initials: A
authors.lastname: Larsson
authors.forename: B
authors.initials: B
authors.lastname: Jonson
mesh_terms: D000328:Adult; D000403:Airway Resistance / Q000502:physiology; D000771:Anesthesia, Intravenous; D004548:Elasticity; D005260:Female; D006801:Humans; D007320:Inspiratory Capacity / Q000502:physiology; D007327:Insufflation; D008168:Lung / Q000503:physiopathology*; D008170:Lung Compliance / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D019148:Neuromuscular Blockade; D011175:Positive-Pressure Respiration; D011312:Pressure; D001261:Pulmonary Atelectasis / Q000503:physiopathology*; D012121:Respiration, Artificial; D014109:Total Lung Capacity / Q000502:physiology