title: Absence of antinociceptive tolerance to improgan, a cimetidine analog, in rats.
abstract: Improgan, an analog of the histamine receptor antagonist cimetidine, produces highly effective analgesia following intraventricular injection. The present study examined changes in the antinociceptive effects of improgan following once daily intraventricular injections. Improgan (100-150 microg) produced near maximal antinociception 10 and 30 min after daily administration on all 4 test days, whereas comparable morphine treatments (50 microg) induced considerable tolerance. Thus, improgan produced highly effective analgesia without the development of tolerance.
authors.affiliation: Department of Pharmacology and Neuroscience, Albany Medical College, Albany, NY, USA.mbannoura@ccgateway.amc.edu
authors.forename: M D
authors.initials: MD
authors.lastname: Bannoura
authors.forename: J W
authors.initials: JW
authors.lastname: Nalwalk
authors.forename: Y
authors.initials: Y
authors.lastname: Tang
authors.forename: M
authors.initials: M
authors.lastname: Carlile
authors.forename: R
authors.initials: R
authors.lastname: Leurs
authors.forename: W M
authors.initials: WM
authors.lastname: Menge
authors.forename: H
authors.initials: H
authors.lastname: Timmerman
authors.forename: L B
authors.initials: LB
authors.lastname: Hough
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D002927:Cimetidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004361:Drug Tolerance; D007276:Injections, Intraventricular; D008297:Male; D010147:Pain Measurement; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D018712:Analgesics, Non-Narcotic; C099531:SKF 92374; D002927:Cimetidine