[Activity of Dipernoids isolated from Azorella compacta (Llareta) on Trypanosoma cruzi amastigotes].
The trypanocidad activity against amastigote forms of SPA-14, Tulahuen and G strains and CL Brener clone of Trypanosoma cruzi of diterpenoids isolated from Azorella compacta, Phil. (Llareta), a plant with ethnomedicinal prestige from prespanish age, was investigated. Amastigocidal activity was shown in azorellanol (2), diterpene isolated by first time, with an inhibitory concentration 50 (IC50) that varied between 60 M (CL Brener clone) and 84 M (SPA-14 strain), and in mulin -11,13 -dien-20-oico acid (5) with IC50 between 41 microM (G strain) and 87 mM (CL Brener clone). The cytotoxicity levels of both compounds against Hela and Vero cells and macrophages J144 are lower than nifurtimox and similar to gentian violet.
Neira
I
I
Unidad de Parasitología, Facultad de Ciencias de la Salud, Universidad de Antofagasta, Chile.
Poblete
L
L
Porcille
P
P
Silva
P
P
Araya
J
J
Bórquez
J
J
Morales
G
G
Loyola
L A
LA
Sagua
H
H
D000818:Animals; D002522:Chlorocebus aethiops; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D008264:Macrophages / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010946:Plants, Medicinal; D014344:Trypanocidal Agents / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000166:cytology / Q000187:drug effects*; D014709:Vero Cells / Q000187:drug effects
D010936:Plant Extracts; D014344:Trypanocidal Agents
Actividad de diterpenoides de Azorella compacta (Llareta) sobre amastigotes de Trypanosoma cruzi.