CD8 T cells in HIV infection: mechanisms of immunity.
CD8 lymphocytes probably play a key role in the immunologic defense against HIV. The evidence is that they control viral replication by at least two mechanisms: direct antigen-specific cytolysis, which appears to be required for optimal suppression, and release of soluble antiviral factors. New therapeutic strategies are taking into account mechanisms by which the virus may evade CD8 control.
Yang
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AIDS Research Center/Infectious Disease Unit, Massachusetts General Hospital, Boston, USA.
D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D018925:Chemokines / Q000276:immunology; D018450:Disease Progression; D015658:HIV Infections / Q000097:blood / Q000276:immunology* / Q000628:therapy / Q000821:virology; D006801:Humans; D013997:Time Factors; D019562:Viral Load; D014779:Virus Replication / Q000276:immunology
D018925:Chemokines