[Study of antigenic determinants of Yersinia pestis lipopolysaccharide using monoclonal antibodies].
Species- and genus-specific antigenic determinants of total serological activity of plague agent lipopolysaccharide (LPS) were detected for the first time with a panel of monoclonal antibodies (MAb) in Y. pestis core polysaccharide in the R-form. MAb specifically bind radicals on one or several monosaccharides of core LPS. Galactose, fucose, and mannose contain common antigenic determinants for enterobacteria; glucosamine, glucose, ribose, xylose, and 2-ketodeoxyoctanoic acid (KDO) contain determinants for Y. pestis and Y. pseudotuberculosis; and epitopes differentiating the two latter agents by the carbohydrate component are localized on glucosamine, mannose, xylose, and KDO. Epitopes common for the Enterobacteriaceae family and species-specific epitopes, two of which are identic to core polysaccharide radicals, are situated on Y. pestis lipid A.
Fedorova
V A
VA
Devdariani
Z L
ZL
D000907:Antibodies, Bacterial / Q000276:immunology*; D000911:Antibodies, Monoclonal / Q000276:immunology; D000942:Antigens, Bacterial / Q000276:immunology*; D018604:Epitope Mapping; D016056:Immunodominant Epitopes / Q000276:immunology*; D008070:Lipopolysaccharides / Q000276:immunology*; D015010:Yersinia pestis / Q000276:immunology*
D000907:Antibodies, Bacterial; D000911:Antibodies, Monoclonal; D000942:Antigens, Bacterial; D016056:Immunodominant Epitopes; D008070:Lipopolysaccharides
Izuchenie antigennykh determinant lipopolisakharida Yersinia pestis s pomoshch'iu monoklonal'nykh antitel.