title: Phase II trial of hyperfractionated accelerated radiation therapy for nonresectable non-small-cell lung cancer: results of Eastern Cooperative Oncology Group 4593.
abstract: OBJECTIVE
  To assess the feasibility, toxicity, and efficacy of hyperfractionated accelerated radiation therapy (HART) for non-small-cell lung cancer (NSCLC).
  
  
  METHODS
  Thirty patients from six institutions with stage IIIA or IIIB NSCLC were enrolled between November 1993 and August 1995. Radiation therapy (total dose, 57.6 Gy in 36 fractions) was delivered over 15 days with the use of three daily fractions with a 4-hour interval between fractions and an 8-hour interval between on-cord fields. Patients were not treated on weekends.
  
  
  RESULTS
  Twenty-eight patients (93%) completed radiation therapy. Treatment-related toxicities of grade 3 or greater included esophagitis in six patients and grade 3 skin reaction in three patients. The overall objective response rate was 54%, and the response rate within the radiation field was 64%. With a minimum follow-up of 19 months in surviving patients, the median survival and 1-year survival rate are 13 months and 57%, respectively. The median relapse-free survival and 1-year relapse-free survival rate are 7 months and 23%, respectively. No transverse myelitis or late toxicities of grade 4 or greater have been observed.
  
  
  CONCLUSIONS
  HART, delivered to a total dose of 57.6 Gy over 15 total days, is practical and well tolerated. Survival appears similar to that seen with modern combined modality regimens. A phase III trial is under way.
authors.affiliation: Department of Human Oncology, University of Wisconsin Medical School, Madison 53792-0600, USA. mehta@humonc.wisc.edu
authors.forename: M P
authors.initials: MP
authors.lastname: Mehta
authors.forename: S P
authors.initials: SP
authors.lastname: Tannehill
authors.forename: S
authors.initials: S
authors.lastname: Adak
authors.forename: L
authors.initials: L
authors.lastname: Martin
authors.forename: D G
authors.initials: DG
authors.lastname: Petereit
authors.forename: H
authors.initials: H
authors.lastname: Wagner
authors.forename: J F
authors.initials: JF
authors.lastname: Fowler
authors.forename: D
authors.initials: D
authors.lastname: Johnson
mesh_terms: D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000532:radiotherapy*; D019583:Dose Fractionation, Radiation; D004941:Esophagitis / Q000209:etiology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D011878:Radiotherapy / Q000009:adverse effects; D016896:Treatment Outcome