title: New macrodiolide antibiotics, 11-O-monomethyl- and 11, 11'-O-dimethylelaiophylins, from Streptomyces sp. HKI-0113 and HKI-0114.
abstract: Elaiophylin (1) and two new methyl derivatives, 11-O-monomethylelaiophylin (2) and 11,11'-O-dimethylelaiophylin (3), were isolated from the mycelium cake of Streptomyces strains HKI-0113 and HKI-0114. The structures of 2 and 3 were determined by mass spectrometric and NMR investigations. Compounds 2 and 3 display antimicrobial and moderate cytotoxic activities.
authors.affiliation: Hans-Knöll-Institute of Natural Products Research, Beutenbergstrasse 11, D-07745 Jena, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Ritzau
authors.forename: S
authors.initials: S
authors.lastname: Heinze
authors.forename: W F
authors.initials: WF
authors.lastname: Fleck
authors.forename: H M
authors.initials: HM
authors.lastname: Dahse
authors.forename: U
authors.initials: U
authors.lastname: Gräfe
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D018942:Macrolides; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D013055:Spectrophotometry, Infrared; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides