title: Synthesis, antifungal activity and antibacterial evaluation of some 3-piperazinylmethyl-5-aryl-1H-1,2,4-triazoles.
abstract: Some new 3-piperazinylmethyl-5-aryl-1H-1,2,4-triazoles have been prepared and tested for their antifungal and antimicrobial activity. Among them, compounds 3g and 3h exhibited higher antifungal activity than ketoconazole against Cladosporium cladosporoides and Aspergillus niger respectively.
authors.affiliation: Department of Pharmacy, School of Medicine, University of Athens, Greece.
authors.forename: S S
authors.initials: SS
authors.lastname: Papakonstantinou-Garoufalias
authors.forename: O G
authors.initials: OG
authors.lastname: Todoulou
authors.forename: E C
authors.initials: EC
authors.lastname: Filippatos
authors.forename: A E
authors.initials: AE
authors.lastname: Papadaki-Valiraki
authors.forename: A
authors.initials: A
authors.lastname: Chytiroglou-Lada
mesh_terms: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D010879:Piperazines; D014230:Triazoles