Contribution to the determination of the chemotherapeutic drug G1 in biological fluids.
A sensitive gas chromatographic method for the quantitative determination of the new antibacterial and antifungal drug G1, 1-(5-bromofuran-2-yl)-2-bromo-2-nitroethene, has been optimized. The method involves a fast and single extraction step from spiked serum and urine samples. The G1 drug was quantified using an internal standard method and by means of a nitrogen-selective detector. The results are statistically significant and show that mean levels of G1 as low as 1 microg ml(-1) can be measured accurately.
Gil del Valle
L
L
Department of Clinical Pharmacology, Institute of Tropical Medicine Pedro Kouri, Ciudad de la Habana, Cuba.
Gebru W/Michael
D
D
Martinez Rodríguez
A
A
Tápanes Peraza
R
R
Ramos
F
F
Pérez Avila
J
J
D000890:Anti-Infective Agents / Q000032:analysis* / Q000097:blood / Q000652:urine; D000935:Antifungal Agents / Q000032:analysis* / Q000097:blood / Q000652:urine; D000970:Antineoplastic Agents / Q000032:analysis* / Q000097:blood / Q000652:urine; D002849:Chromatography, Gas / Q000379:methods*; D005663:Furans / Q000032:analysis* / Q000097:blood / Q000652:urine; D009574:Nitro Compounds / Q000032:analysis* / Q000097:blood / Q000652:urine
D000890:Anti-Infective Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D005663:Furans; D009574:Nitro Compounds