Treatment of non-Hodgkin's lymphoma in the elderly: an update.
Recent studies specifically directed toward assessing the outcome of older patients with non-Hodgkin's lymphoma (NHL) indicate that age per se is an important and independent prognostic factor for response and survival. We report a review of the clinical trials of the literature and the Aviano Group experience in the treatment of NHL in the elderly. Prospective studies have addressed therapeutic approaches in these patients. Direct comparison of trial results is difficult since different age limits were set for the inclusion of patients under study. These studies suggest that older patients with aggressive NHL should be treated with curative intent.
Tirelli
U
U
Division of Medical Oncology A, Centro di Riferimento Oncologico, Aviano, Italy. oma@ets.it
Zagonel
V
V
Errante
D
D
Fratino
L
L
Monfardini
S
S
D000368:Aged; D002173:Cancer Care Facilities; D002986:Clinical Trials as Topic; D006801:Humans; D007558:Italy; D008228:Lymphoma, Non-Hodgkin / Q000628:therapy*; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D012189:Retrospective Studies