Exacerbated immune stress response during experimental magnesium deficiency results from abnormal cell calcium homeostasis.
The aim of this study was to assess the potential mechanism underlying the enhanced inflammatory processes during magnesium deficit. In this study, exacerbated response to live bacteria and platelet activating factors was shown in rats fed a magnesium-deficient diet. Peritoneal cells from these animals also showed enhanced superoxide anion production and calcium mobilising potency following in vitro stimulation. The latter effect occurred very early in the course of magnesium deficiency. These studies first showed that an abnormal calcium handling induced by extracellular magnesium depression in vivo may be at the origin of exacerbated inflammatory response.
Malpuech-Brugère
C
C
I.N.R.A.-Centre de Recherches en Nutrition Humaine, Unité Maladies Métaboliques et Micronutriments, Saint Genès Champanelle, France.
Rock
E
E
Astier
C
C
Nowacki
W
W
Mazur
A
A
Rayssiguier
Y
Y
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D002118:Calcium / Q000276:immunology / Q000378:metabolism*; D004926:Escherichia coli / Q000276:immunology; D007109:Immunity; D017737:Macrophages, Peritoneal / Q000276:immunology*; D008275:Magnesium Deficiency / Q000276:immunology* / Q000378:metabolism; D008297:Male; D010972:Platelet Activating Factor / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar; D016897:Respiratory Burst; D013481:Superoxides / Q000276:immunology / Q000378:metabolism
D000942:Antigens, Bacterial; D010972:Platelet Activating Factor; D013481:Superoxides; D002118:Calcium