Synthesis and antimicrobial activity of N-Mannich bases of 3-[N'-sulphadoximino] isatin and its methyl derivative.
Schiff's bases of isatin and 5-methyl isatin with sulphadoxine and then its N-Mannich bases were synthesised and evaluated for their anti-microbial activity. The piperidonemethyl group improved the activity and most of the compounds were more potent than the pure drugs.
Surendra
Department of Pharmaceutics, Banaras Hindu University, Varanasi, India.
Pandeya
N
N
Yogeeswari
P
P
Ram
D S
DS
Nath
G
G
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D007510:Isatin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008352:Mannich Bases / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D008352:Mannich Bases; D007510:Isatin