title: [Therapeutic effect of Myolastan on increased muscle tone of various etiologies].
abstract: The authors tested in 101 patients the clinical effect of Myolastan (tetrazepam), generic name 1,4, benzodiazepine (BZD), in indications with increased muscular tonus of varying etiology. The drug has a balanced affinity to central and peripheral benzodiazepine receptors, it enhances the presynaptic inhibition of GABAergig neurones at the peripheral and supraspinal level. Clinical experience has shown that a decline of the increased muscular tonus in the affected segment mitigates subjective complaints, in particular pain, if the dosage and time of administration are adjusted for every individual patient. A favourable effect was proved during clinical administration to a heterogeneous group of patients which reflects the spectrum of our ambulatory patients with a locally increase muscle tonus. In addition to vertebrogenic complaints, non-discogenic and discogenic (proved by MR or CT), the group of patients comprised also some with multiple sclerosis. In the latter a favourable effect was recorded in 50%. The effect on spasticity in these patients was comparable with other drugs used by the patients before administration of Myolastan. The heterogeneous group of the remaining patients to whom Myolastan was administered suggests its possible further indications, without the possibility of significant conclusions. Possible side-effects could be eliminated by the administration of low doses in the evening or at night. Myolastan extends the range of drugs which have an impact on an increased muscular tonus.
authors.affiliation: Neurologická klinika 1., Praha.
authors.forename: Z
authors.initials: Z
authors.lastname: Seidl
authors.forename: J
authors.initials: J
authors.lastname: Obenberger
authors.forename: P
authors.initials: P
authors.lastname: Adam
mesh_terms: D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D001569:Benzodiazepines; D005260:Female; D006801:Humans; D008297:Male; D009122:Muscle Hypertonia / Q000188:drug therapy* / Q000209:etiology; D009125:Muscle Relaxants, Central / Q000627:therapeutic use*; D009129:Muscle Tonus / Q000187:drug effects*
chemical_list: D014151:Anti-Anxiety Agents; D009125:Muscle Relaxants, Central; D001569:Benzodiazepines; C005245:tetrazepam
vernacular_title: Lécebné ovlivnĕní zvýseného svalového napĕtí různé etiologie Myolastanem.