Comparison of the DNA damage photoinduced by fenofibrate and ketoprofen, two phototoxic drugs of parent structure.
Fenofibrate and ketoprofen (KP) are two drugs of similar structure derived from that of benzophenone. Both are photoallergic and promote cross reactions in patients. However, the cutaneous photosensitizing properties of KP also include phototoxic effects and are more frequently mentioned. To account for this difference in their in vivo properties, their in vitro photosensitizing properties on DNA were compared. First, it was shown that under irradiation at 313 nm, fenofibric acid (FB), the main metabolite of fenofibrate, photosensitized DNA cleavage by a radical mechanism similar to that proposed for KP but with a 50 times lower efficiency. Furthermore, FB did not photosensitize the formation of pyrimidine dimers into DNA in contrast to KP, which did promote this type of DNA damage. Their difference in efficiency as DNA breakers was compared to their relative photochemical reactivity and the quantum yield of FB photolysis was found to be eightfold lower than that of KP. The reactivity of these drugs cannot explain alone the difference in their photosensitizing properties. Other factors such as the magnitude of the ionic character of the photodecarboxylation pathway of these benzophenone-like drugs are considered in the discussion.
Marguery
M C
MC
Laboratoire des I.M.R.C.P., UMR CNRS, Université Paul Sabatier, Toulouse, France.
Chouini-Lalanne
N
N
Ader
J C
JC
Paillous
N
N
D010584:Bacteriophage phi X 174; D003497:Cyclic N-Oxides; D004249:DNA Damage; D004278:DNA, Superhelical / Q000187:drug effects* / Q000528:radiation effects; D004279:DNA, Viral / Q000187:drug effects* / Q000528:radiation effects; D011345:Fenofibrate / Q000494:pharmacology*; D007660:Ketoprofen / Q000494:pharmacology*; D010782:Photolysis; D017319:Photosensitizing Agents / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects / Q000528:radiation effects; D013113:Spin Labels
D003497:Cyclic N-Oxides; D004278:DNA, Superhelical; D004279:DNA, Viral; D017319:Photosensitizing Agents; D013113:Spin Labels; C017245:5,5-dimethyl-1-pyrroline-1-oxide; D007660:Ketoprofen; D011345:Fenofibrate