[Fungemia in patients with HIV infection].
OBJECTIVE
To make an analysis of fungemia in HIV-infected patients in our hospital.


METHODS
We retrospectively (1989-1997) studied all HIV-infected patients with positive blood cultures for Candida sp., Cryptococcus neoformans or any other fungal infection.


RESULTS
C. neoformans was isolated in 11 patients (10 men and 1 woman): Six were treated with amphotericin B and 5 with fluconazole. 2 patients died during the acute phase and the infection relapsed in 3. Blood culture for Candida sp. were positive in 9 (8 men and 1 woman): only a case was nosocomial. Seven patients were intravenous drug users and the presenting manifestations were autolimited candidemia in 3, aortic and tricuspid endocarditis in 1 and 2 cases respectively and pneumonia in another one. Six C. albicans, 2 C. krusei and 1 C. glabrata were isolated. 3 patients received amphotericin B and 3 received fluconazole. 2 patients suffering from endocarditis died and so did the patient with C. glabrata infection. A patient, who denied having travelled to endemic areas, developed histoplasmosis; blood culture was positive for H. capsulatum. He initially had a good response to amphotericin B and itraconazole.


CONCLUSIONS
Fungemia is not frequent in HIV-infected patients. Cryptococcosis and histoplasmosis occur in advanced HIV-patients and candidemia is fundamentally associated with intravenous drug use.
Santos
J
J
Unidad de Infecciosos, Hospital Virgen de la Victoria, Málaga.
Palacios
R
R
Esteve
A
A
García
V
V
Rivero
A
A
Márquez
M
M
D000328:Adult; D002177:Candidiasis / Q000150:complications; D003453:Cryptococcosis / Q000150:complications; D003455:Cryptococcus neoformans; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000150:complications*; D012189:Retrospective Studies
Fungemias en pacientes con infección por VIH.