[Antithrombotic activity of complexes of superoxide dismutase with chondroitin sulfate in arterial damage in rats].
The comparative antithrombotic activity of superoxide dismutase and chondroitin sulfate in the form of covalent or noncovalent complexes was studied on the rat arterial thrombosis induced by treatment of vessel with ferrous chloride solution. The covalent conjugate between superoxide dismutase and chondroitin sulfate has been shown to exert the highest antithrombotic effect. The higher antithrombotic activity of covalent conjugate is stipulated by its coupling on the glycocalyx of vascular wall and by the stability of the covalent bond between superoxide dismutase subunits and chondroitin sulfate.
Maksimenko
A V
AV
Institute of Experimental Cardiology, Russian Cardiology Research Centre, Moscow, Russia.
Tishchenko
E G
EG
Golubykh
V L
VL
D000818:Animals; D001158:Arteries / Q000473:pathology*; D002809:Chondroitin Sulfates / Q000737:chemistry / Q000627:therapeutic use*; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D051381:Rats; D013482:Superoxide Dismutase / Q000737:chemistry / Q000627:therapeutic use*; D013927:Thrombosis / Q000188:drug therapy*
D005343:Fibrinolytic Agents; D002809:Chondroitin Sulfates; D013482:Superoxide Dismutase
Antitromboticheskaia aktivnost' kompleksov superoksidismutazy s khondroitinsul'fatom pri arterial'nom porazhenii u krys.