title: Is acute rejection deleterious to long-term liver allograft function?
abstract: OBJECTIVE
  The decreasing incidence of chronic rejection after liver transplantation emphasizes the need for an alternative end-point to assess the long-term consequences of acute rejection. The purpose of this study was to determine the effects of resolved episodes of acute rejection on late liver allograft function.
  
  
  METHODS
  Parameters of hepatic function (liver biochemistry, indocyanine green and sulfobromophthalein clearances, histology) were analyzed in 170 consecutive adult recipients, who were followed prospectively on the basis of repeat annual work-up. Mean follow-up was 3.7+/-0.2 years.
  
  
  RESULTS
  The rates of acute and chronic rejection were 51% and 4.1%, respectively. At the last follow-up, there was no significant difference in graft function between patients with a single episode of acute rejection (n=56) and those without rejection (n=84). Among patients treated for a single episode of acute rejection, late hepatic function was not influenced by the severity of acute rejection and the response to corticosteroids. In contrast, patients with recurrent acute rejection (n=30) had significant impairment of liver function tests (aspartate aminotransferase, p<0.05; alanine aminotransferase, p<0.01; alkaline phosphatase, p<0.01; gamma-glutamyl transpeptidase, p<0.001), lower dye clearances (indocyanine green, p<0.01; sulfobromophthalein, p<0.01) and more severe histologic damage (p<0.001).
  
  
  CONCLUSIONS
  Single episodes of acute rejection do not impair the long-term hepatic function, whereas recurrent episodes leave sequellar damage to the liver allograft. These results provide a rationale for converting patients with rejection to a heavier immunosuppressive regimen, while leaving nearly half the recipients on a lifelong light immunosuppressive regimen.
authors.affiliation: Department of Surgery, Hôpital Cochin, Paris, France.
authors.forename: B
authors.initials: B
authors.lastname: Dousset
authors.forename: F
authors.initials: F
authors.lastname: Conti
authors.forename: B
authors.initials: B
authors.lastname: Cherruau
authors.forename: A
authors.initials: A
authors.lastname: Louvel
authors.forename: O
authors.initials: O
authors.lastname: Soubrane
authors.forename: D
authors.initials: D
authors.lastname: Houssin
authors.forename: Y
authors.initials: Y
authors.lastname: Calmus
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006084:Graft Rejection; D006526:Hepatitis C / Q000209:etiology; D006801:Humans; D007165:Immunosuppression Therapy; D008099:Liver / Q000503:physiopathology*; D016031:Liver Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014184:Transplantation, Homologous