title: [Uveitis in Whipple disease: Identification of Trophyrema whippelii by PCR].
abstract: Whipple's disease is a multisystem bacterial disease usually characterized by malabsorption, diarrhea and polyarthritis. Ocular manifestations include uveitis, vitreitis, retinis, myositis, papilledema and optic atrophy. We report a case of a chronic bilateral vitreitis in a 63 year-old man who had been treated for a Whipple's disease with gastrointestinal involvement 30 years before. The jejunal biopsy was negative but the polymerase-chain-reaction (PCR) revealed the presence of Trophyrema Whippelii in the vitreous prelevement of both eye. This new, original strategy of PCR is specific and more sensitive than histological diagnosis.
authors.affiliation: Service d'Ophtalmologie, CHR Metz Thionville, Hôpital N.D. de Bonsecours, Metz.
authors.forename: S
authors.initials: S
authors.lastname: Sommer
authors.forename: P
authors.initials: P
authors.lastname: Rozot
authors.forename: M
authors.initials: M
authors.lastname: Wagner
authors.forename: L
authors.initials: L
authors.lastname: Xenard
authors.forename: J D
authors.initials: JD
authors.lastname: Poveda
mesh_terms: D000190:Actinomyces / Q000235:genetics / Q000302:isolation & purification*; D001706:Biopsy; D003937:Diagnosis, Differential; D006801:Humans; D007583:Jejunum / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D014605:Uveitis / Q000175:diagnosis* / Q000382:microbiology; D014822:Vitreous Body / Q000382:microbiology*; D008061:Whipple Disease / Q000175:diagnosis* / Q000382:microbiology
chemical_list: D012336:RNA, Ribosomal, 16S
vernacular_title: Uvéite et maladie de Whipple: identification du Trophyrema whippelii par PCR.