title: Effect of age upon airway obstruction and reversibility in adult patients with asthma.
abstract: OBJECTIVE
  In a cross-sectional study we evaluated the effect of aging (separately from that of duration of disease) on airway obstruction and reversibility by comparing two groups of non-smoker patients with asthma.
  
  
  METHODS
  We compared two groups of patients: group A, which had 50 subjects (8 men and 42 women) aged 59.7+/-4.6 years (mean +/- SD), and group B, comprised of 51 subjects (19 men and 32 women) who were 35.7+/-7.4 years old. The groups were selected because of comparable baseline degree of obstruction (FEV1 % of predicted, 67.8+/-20.3 in group A; 73.0+/-19.6 in group B, NS) and duration of the disease (14.0+/-11.7 years vs 11.2+/-9.1, NS). Spirometric examination, with a bronchodilator test, was performed and subjects not reaching 85% of predicted were submitted to a 4-week course of inhaled steroids.
  
  
  RESULTS
  Although a higher number of subjects from group B responded to the acute bronchodilator test (p < 0.001), the maximum response achievable with treatment (steroid or bronchodilator) (deltaFEV1 expressed as the percent of predicted) was not statistically different between groups (12.0+/-17.5 vs 16.0+/-23.9). The mean FEV1 attainable after treatment (deltaFEV1%PT) was significantly lower in the older group (p = 0.0006). Within groups, the baseline FEV1% did not correlate with age; it was inversely correlated with the duration of the disease (p < 0.03 and p < 0.01, respectively). In both groups deltaFEV1 was inversely related with the baseline FEV1, whereas FEV1%PT was correlated with the duration of the disease, with a slope nearly doubled in group B (p < 0.001).
  
  
  CONCLUSIONS
  Both the process of aging and the prolonged exposure to disease effects are important factors in determining the functional characteristics of chronic asthma: In particular, aging is associated not only with a reduced acute responsiveness to bronchodilators, but also with a reduced slope of the duration-FEV1%PT relationship that suggests a slowing of the rate of loss of reversibility of uncertain biological meaning.
authors.affiliation: Istituto di Fisiopatologia Respiratoria del C.N.R. and Istituto di Pneumologia dell'Università, Palermo, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Bellia
authors.forename: F
authors.initials: F
authors.lastname: Cibella
authors.forename: G
authors.initials: G
authors.lastname: Cuttitta
authors.forename: N
authors.initials: N
authors.lastname: Scichilone
authors.forename: G
authors.initials: G
authors.lastname: Mancuso
authors.forename: A M
authors.initials: AM
authors.lastname: Vignola
authors.forename: G
authors.initials: G
authors.lastname: Bonsignore
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D000402:Airway Obstruction / Q000503:physiopathology; D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology*; D001985:Bronchial Provocation Tests; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D015656:Respiratory Mechanics; D013147:Spirometry; D014797:Vital Capacity