title: Clinical analysis of the neodymium:YLF picosecond laser as a microkeratome for laser in situ keratomileusis. Partially Sighted Eye Study.
abstract: OBJECTIVE
  To evaluate the use of a picosecond neodymium:YLF (Nd:YLF) laser as a nonmechanical intrastromal microkeratome.
  
  
  METHODS
  Universita Cattolica del Sacro Cuore, Rome, Italy.
  
  
  METHODS
  An intrastromal spiral disc pattern of picosecond laser pulses was used to create a corneal flap for laser in situ keratomileusis (LASIK) in 14 partially sighted eyes.
  
  
  RESULTS
  Flaps with a 6.0 mm diameter and 180 to 200 microns depth were successfully created in most cases. The underlying stroma was treated with a Lambda Physik excimer laser using a 3.5 to 4.5 mm optical zone. Patients were divided into 3 groups for target corrections of 5.0, 10.0, and 15.0 diopters of myopia. Good corneal clarity and refractive undercorrection were recorded in each group 6 months postoperatively. The undercorrection was due in part to the limited optical zone of the laser's delivery system. Some flap decentration was noted.
  
  
  CONCLUSIONS
  This pilot study indicates that the Nd:YLF picosecond laser may be clinically applied for creating corneal flaps for LASIK. Further refinements of the laser delivery system will include enlargement of the flap diameter and improvements in flap centration. The use of a femtosecond laser may expand the capabilities and precision of this technology.
authors.affiliation: Saint Louis University Eye Institute, Missouri 63104, USA.
authors.forename: R R
authors.initials: RR
authors.lastname: Krueger
authors.forename: V
authors.initials: V
authors.lastname: Marchi
authors.forename: A
authors.initials: A
authors.lastname: Gualano
authors.forename: T
authors.initials: T
authors.lastname: Juhasz
authors.forename: M
authors.initials: M
authors.lastname: Speaker
authors.forename: C
authors.initials: C
authors.lastname: Suárez
mesh_terms: D000328:Adult; D000368:Aged; D001766:Blindness / Q000601:surgery*; D003319:Corneal Stroma / Q000601:surgery*; D019781:Corneal Topography; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000295:instrumentation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000601:surgery*; D013508:Ophthalmologic Surgical Procedures; D010865:Pilot Projects; D013524:Surgical Flaps; D016896:Treatment Outcome; D014792:Visual Acuity