title: Effects of short term increase of intraocular pressure on optic disc cupping.
abstract: OBJECTIVE
  To evaluate the effect of acute elevation of intraocular pressure (IOP) on optic disc cupping.
  
  
  METHODS
  10 emmetropic and 10 myopic volunteers were included in this study. The cup area (CA) and cup volume (CV) of the optic disc were determined with the Heidelberg retina tomograph (HRT). After baseline determinations, a suction cup was used to increase the intraocular pressure (IOP) to 20-25 mm Hg above the baseline and HRT images were obtained.
  
  
  RESULTS
  Baseline IOP was 13.5 (SD 1.3) nim Hg and 12.6 (2.6) mm Hg in the emmetropic and myopic groups, respectively. The IOP was elevated to 35.4 (3.3) mm Hg and 34.4 (2.5) mm Hg in the emmetropic and myopic groups, respectively. When compared with their baseline values, the cupping variables (CA and CV) were significantly increased (p < 0.05) during the suction treatment in both emmetropic and myopic subjects.
  
  
  CONCLUSIONS
  There was a significant enlargement in the optic disc cupping during the artificial increment of intraocular pressure in both emmetropic and myopic eyes. In non-glaucomatous eyes the optic nerve head has a partially dynamic topography dependent upon the level of IOP.
authors.affiliation: Department of Ophthalmology, Nottingham University Medical School, Nottingham.
authors.forename: A
authors.initials: A
authors.lastname: Azuara-Blanco
authors.forename: A
authors.initials: A
authors.lastname: Harris
authors.forename: L B
authors.initials: LB
authors.lastname: Cantor
authors.forename: M M
authors.initials: MM
authors.lastname: Abreu
authors.forename: M
authors.initials: M
authors.lastname: Weinland
mesh_terms: D000328:Adult; D005901:Glaucoma / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008875:Middle Aged; D009216:Myopia / Q000150:complications / Q000503:physiopathology; D009898:Optic Disk / Q000473:pathology / Q000503:physiopathology*; D014054:Tomography