title: Maximum likelihood as a common computational framework in tomotherapy.
abstract: Tomotherapy is a dose delivery technique using helical or axial intensity modulated beams. One of the strengths of the tomotherapy concept is that it can incorporate a number of processes into a single piece of equipment. These processes include treatment optimization planning, dose reconstruction and kilovoltage/megavoltage image reconstruction. A common computational technique that could be used for all of these processes would be very appealing. The maximum likelihood estimator, originally developed for emission tomography, can serve as a useful tool in imaging and radiotherapy. We believe that this approach can play an important role in the processes of optimization planning, dose reconstruction and kilovoltage and/or megavoltage image reconstruction. These processes involve computations that require comparable physical methods. They are also based on equivalent assumptions, and they have similar mathematical solutions. As a result, the maximum likelihood approach is able to provide a common framework for all three of these computational problems. We will demonstrate how maximum likelihood methods can be applied to optimization planning, dose reconstruction and megavoltage image reconstruction in tomotherapy. Results for planning optimization, dose reconstruction and megavoltage image reconstruction will be presented. Strengths and weaknesses of the methodology are analysed. Future directions for this work are also suggested.
authors.affiliation: Department of Medical Physics, University of Wisconsin-Madison, 53706, USA.
authors.forename: G H
authors.initials: GH
authors.lastname: Olivera
authors.forename: D M
authors.initials: DM
authors.lastname: Shepard
authors.forename: P J
authors.initials: PJ
authors.lastname: Reckwerdt
authors.forename: K
authors.initials: K
authors.lastname: Ruchala
authors.forename: J
authors.initials: J
authors.lastname: Zachman
authors.forename: E E
authors.initials: EE
authors.lastname: Fitchard
authors.forename: T R
authors.initials: TR
authors.lastname: Mackie
mesh_terms: D000465:Algorithms; D055592:Biophysical Phenomena; D001703:Biophysics; D006801:Humans; D016013:Likelihood Functions; D008962:Models, Theoretical; D009369:Neoplasms / Q000532:radiotherapy; D019047:Phantoms, Imaging; D011857:Radiographic Image Interpretation, Computer-Assisted; D011880:Radiotherapy Planning, Computer-Assisted / Q000706:statistics & numerical data*; D011882:Radiotherapy, High-Energy; D014057:Tomography, X-Ray Computed