title: Re-implantation of autoclaved bone segments in musculoskeletal tumor surgery. Clinical experience in 9 patients followed for 1.1-8.4 years and review of the literature.
abstract: Nine patients who had malignant bone tumors of the lower extremity were managed with wide en bloc resection and re-implantation of the extracorporeally autoclaved specimens. The segments were fixed by plate osteosynthesis, knee arthrodesis rod, or intramedullary nails. In one patient the complete femur was re-implanted. After a mean follow-up of 66 months (range 13-101 months), 8 out of 9 patients were still free of disease. One patient with Ewing's sarcoma and re-implantation of the complete femur died of systemic recurrence. No local recurrence was seen. One patient with Ewing's sarcoma of the tibia who had undergone postoperative irradiation developed a local infection 18 months postoperatively which finally had to be treated by knee disarticulation. After an average duration of 13 months, all graft-host junctions had healed. The functional result of the patient with the knee disarticulation was poor. In all other patients, the functional outcome was good or excellent. The evaluation of 115 patients (106 from the literature, 9 from our study) with a mean follow-up of 63 months showed 8 local recurrences. There were 4 secondary infections and only 1 primary infection. In tumors of the extremities and the pelvis, the functional outcome was excellent or good in about 80%. Limb salvage using re-implantation of autoclaved tumor-bearing bone segments for reconstruction has a low complication rate and good functional results in appropriately selected patients compared with other options of management.
authors.affiliation: Department of Orthopedics, Eberhard Karls University Tübingen, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Böhm
authors.forename: R
authors.initials: R
authors.lastname: Springfeld
authors.forename: H
authors.initials: H
authors.lastname: Springer
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D001859:Bone Neoplasms / Q000473:pathology / Q000601:surgery*; D001842:Bone and Bones / Q000473:pathology / Q000601:surgery*; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D019042:Muscle Neoplasms / Q000473:pathology / Q000601:surgery*; D012092:Replantation / Q000379:methods*; D013242:Sterilization / Q000379:methods*; D013997:Time Factors