The versatility of inositol phosphates as cellular signals.
Cells from across the phylogenetic spectrum contain a variety of inositol phosphates. Many different functions have been ascribed to this group of compounds. However, it is remarkable how frequently several of these different inositol phosphates have been linked to various aspects of signal transduction. Therefore, this review assesses the evidence that inositol phosphates have evolved into a versatile family of second messengers.
Shears
S B
SB
Inositide Signalling Section, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. shears@niehs.nih.gov
D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism; D007295:Inositol Phosphates / Q000378:metabolism*; D015290:Second Messenger Systems; D015398:Signal Transduction
D007295:Inositol Phosphates; C081655:inositol-1,3,4,5-tetrakisphosphate; C081652:inositol-3,4,5,6-tetrakisphosphate; C081651:inositol-1,4,5,6-tetrakisphosphate; C013571:inositol pentaphosphate; D015544:Inositol 1,4,5-Trisphosphate