title: The consequences of a major bile duct injury during laparoscopic cholecystectomy.
abstract: Bile duct injury is perhaps the most feared complication of laparoscopic cholecystectomy. The focus of this study was on the immediate and short-term outcome of patients who have undergone repair of major bile duct injuries with respect to hospital stay, perioperative interventions, and reoperations. The records of patients who underwent surgery at three academic hospitals in Philadelphia (Hospital of the University of Pennsylvania, Thomas Jefferson University Hospital, and Graduate Hospital) from 1990 to 1995 for repair of a major biliary injury following laparoscopic cholecystectomy were reviewed. A major biliary injury was defined as any disruption (including ligation, avulsion, or resection) of the extrahepatic biliary system. Small biliary leaks not requiring surgery were excluded. Thirty-two patients sustained major bile duct injuries. The injury was recognized immediately in 10 patients. The remaining 22 patients had pain (59%), jaundice (50%), and/or fever (32%) as the symptom heralding the injury. Bismuth classification was as follows: 13% of patients were class I, 63% were class II, 7% were class III, 7% were class IV, and 10% were class V. Biliary reconstruction included a Roux-en-Y hepaticojejunostomy in 30 patients and two were primary repairs. There was one postoperative death from multiorgan system failure. The mean length of hospital stay after repair was 17 +/- 8 days. Over a mean follow-up period of 11.5 +/- 10.5 months, 11 patients (38%) required 19 emergency readmissions, most commonly for cholangitis. Five patients (17%) required postoperative balloon dilatation for biliary stricture. At follow-up 18 patients (62.0%) remain asymptomatic with normal liver function, eight (28%) are experiencing episodic cholangitis, and three (10%) are asymptomatic with persistently elevated liver function values. The consequences of a major biliary tract injury following laparoscopic cholecystectomy include a complex operative repair resulting in a lengthy postoperative stay with an increased risk of death, an excessive number of perioperative diagnostic and therapeutic studies, frequent readmissions (often as emergencies), and a lifelong risk of restricture. The "cost" to these patients remains enormous.
authors.affiliation: Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: T W
authors.initials: TW
authors.lastname: Bauer
authors.forename: J B
authors.initials: JB
authors.lastname: Morris
authors.forename: A
authors.initials: A
authors.lastname: Lowenstein
authors.forename: C
authors.initials: C
authors.lastname: Wolferth
authors.forename: F E
authors.initials: FE
authors.lastname: Rosato
authors.forename: E F
authors.initials: EF
authors.lastname: Rosato
mesh_terms: D000328:Adult; D000368:Aged; D000713:Anastomosis, Roux-en-Y; D017734:Bile Ducts, Extrahepatic / Q000293:injuries* / Q000601:surgery; D002404:Catheterization; D002423:Cause of Death; D002761:Cholangitis / Q000209:etiology; D017081:Cholecystectomy, Laparoscopic / Q000009:adverse effects* / Q000191:economics; D001651:Cholestasis, Extrahepatic / Q000209:etiology / Q000628:therapy; D017281:Cost of Illness; D005260:Female; D005334:Fever / Q000209:etiology; D005500:Follow-Up Studies; D006760:Hospitalization; D006801:Humans; D007431:Intraoperative Complications / Q000145:classification / Q000601:surgery; D007565:Jaundice / Q000209:etiology; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000209:etiology; D010149:Postoperative Pain / Q000209:etiology; D010359:Patient Readmission; D015143:Philadelphia; D011171:Portoenterostomy, Hepatic; D011183:Postoperative Complications; D012086:Reoperation; D012307:Risk Factors; D016896:Treatment Outcome