Ulinastatin, a protease inhibitor, attenuates hepatic ischemia/reperfusion injury by downregulating TNF-alpha in the liver.
Aihara
T
T
First Department of Surgery, National Defence Medical College, Saitama, Japan.
Shiraishi
M
M
Hiroyasu
S
S
Hatsuse
K
K
Mochizuki
H
H
Seki
S
S
Hiraide
H
H
Muto
Y
Y
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D005786:Gene Expression Regulation / Q000187:drug effects*; D006023:Glycoproteins / Q000494:pharmacology*; D007511:Ischemia / Q000378:metabolism / Q000503:physiopathology*; D008099:Liver / Q000098:blood supply* / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009504:Neutrophils / Q000502:physiology; D009926:Organ Preservation / Q000379:methods*; D051381:Rats; D017208:Rats, Wistar; D015424:Reperfusion; D015427:Reperfusion Injury / Q000517:prevention & control*; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D014361:Trypsin Inhibitors / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D006023:Glycoproteins; D017392:Thiobarbituric Acid Reactive Substances; D014361:Trypsin Inhibitors; D014409:Tumor Necrosis Factor-alpha; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; C028665:urinastatin