title: The effects of postoperative continuous passive motion on peripheral nerve repair and regeneration. An experimental investigation in rabbits.
abstract: The effects of continuous passive motion (CPM) on nerve regeneration following nerve repair were investigated. In 26 rabbits, the medial popliteal nerve was transected and microsurgically repaired. Half of the animals were treated with cast immobilization and the rest with 70 degrees arc CPM. Both treatments were discontinued on day 14. After sacrifice on day 100, no animal showed separation at the suture line. Mean nerve conduction velocity was slightly slower in the CPM than in the immobilization group. Mean fibre density was also slightly less in the CPM group but the difference was not significant. Mean fibre diameters, fibre diameter distributions, and soleus-muscle wet weights were similar in the two groups.
authors.affiliation: Hospital for Sick Children Research Institute, Toronto, Canada.
authors.forename: H K
authors.initials: HK
authors.lastname: Kim
authors.forename: R G
authors.initials: RG
authors.lastname: Kerr
authors.forename: C B
authors.initials: CB
authors.lastname: Turley
authors.forename: P J
authors.initials: PJ
authors.lastname: Evans
authors.forename: V
authors.initials: V
authors.lastname: Jay
authors.forename: R B
authors.initials: RB
authors.lastname: Salter
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000704:Analysis of Variance; D000818:Animals; D001369:Axons / Q000473:pathology / Q000502:physiology; D002370:Casts, Surgical; D005500:Follow-Up Studies; D007091:Image Processing, Computer-Assisted; D007103:Immobilization; D008866:Microsurgery; D015915:Motion Therapy, Continuous Passive; D018482:Muscle, Skeletal / Q000473:pathology; D009412:Nerve Fibers / Q000473:pathology / Q000502:physiology; D009413:Nerve Fibers, Myelinated / Q000473:pathology / Q000502:physiology; D009416:Nerve Regeneration / Q000502:physiology*; D009431:Neural Conduction / Q000502:physiology; D009929:Organ Size; D011182:Postoperative Care; D011817:Rabbits; D013979:Tibial Nerve / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*