title: Colonization with Pseudomonas aeruginosa in patients developing ventilator-associated pneumonia.
abstract: To determine routes of colonization and genotypic variation of Pseudomonas aeruginosa leading to ventilator-associated pneumonia, colonization of the rectum, stomach, oropharynx, and trachea was studied chronologically in 10 patients. Ninety-one isolates of P aeruginosa were genotyped; seven different genotypes were identified. Patients developing ventilator-associated pneumonia caused by P aeruginosa were colonized at multiple body sites and may be colonized with multiple genotypes. The upper respiratory tract is the predominant initial site of colonization with P aeruginosa.
authors.affiliation: Department of Internal Medicine, University Hospital Maastricht, The Netherlands.
authors.forename: D C
authors.initials: DC
authors.lastname: Bergmans
authors.forename: M J
authors.initials: MJ
authors.lastname: Bonten
authors.forename: E E
authors.initials: EE
authors.lastname: Stobberingh
authors.forename: F H
authors.initials: FH
authors.lastname: van Tiel
authors.forename: S
authors.initials: S
authors.lastname: van der Geest
authors.forename: P W
authors.initials: PW
authors.lastname: de Leeuw
authors.forename: C A
authors.initials: CA
authors.lastname: Gaillard
mesh_terms: D006801:Humans; D009960:Oropharynx / Q000382:microbiology; D018410:Pneumonia, Bacterial / Q000209:etiology* / Q000382:microbiology / Q000517:prevention & control; D011446:Prospective Studies; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification*; D012007:Rectum / Q000382:microbiology; D012121:Respiration, Artificial / Q000009:adverse effects*; D013270:Stomach / Q000382:microbiology; D014132:Trachea / Q000382:microbiology