Cardiovascular control during concomitant dynamic leg exercise and static arm exercise in humans.
1. Skeletal muscle blood flow is thought to be determined by a balance between sympathetic vasoconstriction and metabolic vasodilatation. The purpose of this study was to assess the importance of high levels of sympathetic vasoconstrictor activity in control of blood flow to human skeletal muscle during dynamic exercise. 2. Muscle sympathetic nerve activity to the exercising leg was increased by static or static ischaemic arm exercise added to on-going dynamic leg exercise. Ten subjects performed light (20 W) or moderate (40 W) dynamic knee extension for 6 min with one leg alone or concomitant with bilateral static handgrip at 20% of maximal voluntary contraction force with or without forearm muscle ischaemia or post-exercise forearm muscle ischaemia. 3. Muscle sympathetic nerve activity was measured by microneurography (peroneal nerve) and leg muscle blood flow by a constant infusion thermodilution technique (femoral vein). 4. Activation of an exercise pressor reflex from the arms, causing a 2- to 4-fold increase in muscle sympathetic nerve activity and a 15-32% increase in mean arterial blood pressure, did not affect blood flow to the dynamically exercising leg muscles at any level of leg exercise. Leg vascular conductance was reduced in line with the higher perfusion pressure. 5. The results demonstrate that the vasoconstrictor effects of high levels of muscle sympathetic nerve activity does not affect blood flow to human skeletal muscle exercising at moderate intensities. One question remaining is whether the observed decrease in muscle vascular conductance is the result of sympathetic vasoconstriction or metabolic autoregulation of muscle blood flow.
Strange
S
S
The Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark.
D000328:Adult; D001132:Arm / Q000098:blood supply / Q000502:physiology*; D001794:Blood Pressure; D002302:Cardiac Output; D002320:Cardiovascular Physiological Phenomena; D004837:Epinephrine / Q000097:blood; D005947:Glucose / Q000493:pharmacokinetics; D018737:Hand Strength / Q000502:physiology; D006339:Heart Rate; D006801:Humans; D007511:Ischemia / Q000378:metabolism / Q000503:physiopathology; D019344:Lactic Acid / Q000378:metabolism; D007866:Leg / Q000098:blood supply / Q000502:physiology*; D008297:Male; D018482:Muscle, Skeletal / Q000098:blood supply / Q000294:innervation / Q000502:physiology; D009638:Norepinephrine / Q000097:blood; D010101:Oxygen Consumption / Q000502:physiology; D005082:Physical Exertion / Q000502:physiology*; D012018:Reflex / Q000502:physiology; D012039:Regional Blood Flow / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology; D014661:Vasoconstriction / Q000502:physiology; D014664:Vasodilation / Q000502:physiology
D019344:Lactic Acid; D005947:Glucose; D009638:Norepinephrine; D004837:Epinephrine