title: Effect of radiofrequency catheter ablation on parasympathetic denervation: a comparison of three different ablation sites.
abstract: Radiofrequency (RF) catheter ablation of supraventricular tachycardias (SVT) has been shown to result in local parasympathetic denervation. The purpose of this study was to estimate the correlation between RF cumulative energy and parasympathetic denervation at three different ablation sites.
  
  
  METHODS
  45 patients who underwent RF ablation of 36 AV reentrant tachycardias and 9 AV nodal reentrant tachycardias were studied. Twenty patients had left free-wall accessory pathways (group L), 8 patients right free-wall accessory pathways (group R), and 17 patients septal accessory pathways (n = 8) or slow pathways (n = 9) (group S). Time and frequency domain analysis of heart rate variability on 24-hour ambulatory ECG recordings was performed before and after RF ablation. pNN50 and the high frequency (0.15 to 0.40 Hz, HF) component were measured to examine the effects on parasympathetic nerve activity. The values of delta pNN50 and delta HF were expressed as the percent change of pNN50 and HF that occurred after versus before RF ablation.
  
  
  RESULTS
  Both pNN50 and HF significantly decreased after RF ablation in all three groups. In group S, there was a significant correlation between RF cumulative energy and delta pNN50 (r = 0.66, P < 0.01) or delta HF (r = 0.58, P < 0.05). In contrast, there was no correlation between RF cumulative energy and delta pNN50 or delta HF in either group L or group R.
  
  
  CONCLUSIONS
  These data suggest that RF ablation produces parasympathetic denervation at all three sites along the mitral or tricuspid annulus and that parasympathetic fibers may be located predominantly in the septal area.
authors.affiliation: Matsusaka City Hospital, Department of Clinical Laboratory, Mie, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Uchida
authors.forename: A
authors.initials: A
authors.lastname: Kasai
authors.forename: C
authors.initials: C
authors.lastname: Omichi
authors.forename: E
authors.initials: E
authors.lastname: Fujii
authors.forename: S
authors.initials: S
authors.lastname: Teramura
authors.forename: M
authors.initials: M
authors.lastname: Yasuda
authors.forename: T
authors.initials: T
authors.lastname: Nakano
mesh_terms: D000328:Adult; D017115:Catheter Ablation; D015716:Electrocardiography, Ambulatory; D005260:Female; D006321:Heart / Q000294:innervation; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D017764:Parasympathectomy; D010275:Parasympathetic Nervous System / Q000502:physiology / Q000601:surgery; D013611:Tachycardia, Atrioventricular Nodal Reentry / Q000503:physiopathology / Q000601:surgery*; D013617:Tachycardia, Supraventricular / Q000503:physiopathology / Q000601:surgery*