title: Thrombopoietin concentration in umbilical cord blood of healthy term newborns is higher than in adult controls.
abstract: Thrombopoietin (TPO) concentrations were determined in umbilical cord plasma of 121 healthy term newborns. The lower detection limit of the enzyme immunoassay employed was 32.5 pg/ml. Median cord plasma TPO concentration was 78 (interquartile range 55-107) pg/ml. 95th percentile was 255 pg/ml. In only 8% (10/121), TPO was below the detection limit compared to 81% of healthy adults (25/31). In cord blood and adult controls, there were no significant correlations of TPO with platelet count or mass.
authors.affiliation: Department of Neonatology, Virchow Hospital, Humboldt University, Berlin, Germany. michael.obladen@charite.de
authors.forename: M M
authors.initials: MM
authors.lastname: Walka
authors.forename: J
authors.initials: J
authors.lastname: Sonntag
authors.forename: J W
authors.initials: JW
authors.lastname: Dudenhausen
authors.forename: M
authors.initials: M
authors.lastname: Obladen
mesh_terms: D000328:Adult; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007124:Immunoenzyme Techniques; D007231:Infant, Newborn; D008297:Male; D010976:Platelet Count; D012016:Reference Values; D013926:Thrombopoietin / Q000097:blood*
chemical_list: D013926:Thrombopoietin