[Intraarterial chemotherapy using a combination of etoposide and cisplatin for recurrent malignant lymphoma].
Superselective intraarterial infusion of etoposide and cisplatin was performed in 2 patients with recurrent malignant lymphoma which had progressed after operation, radiotherapy and chemotherapy with various anticancer agents. The tip of a microcatheter (Tracker-18) was placed in the left posterior cerebral artery in the first patient with the recurrent tumor located in the left occipital lobe and at the basilar top in the second patient with the recurrent tumor extending from the right thalamus to the pons. Etoposide (60 mg) and Cisplatin (60 mg) were each infused for 1 hour safely with a combination of intermittent infusion of nicardipine and papaverine chloride. The tumor disappeared completely after 2 courses of intraarterial chemotherapy in the first patient and after 1 course in the second patient. Intraarterial chemotherapy using a combination of etoposide and cisplatin was performed safely and showed good results.
Hirayama
A
A
Dept. of Neurosurgery, Osaka Medical Center for Cancer & Cardiovascular Diseases.
Nakagawa
H
H
Maeda
N
N
Tsuzuki
T
T
Yamamoto
H
H
Kadota
T
T
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D002945:Cisplatin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis / Q000188:drug therapy*; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000188:drug therapy*; D008279:Magnetic Resonance Imaging
D005047:Etoposide; D002945:Cisplatin