title: High incidence of adeno- and polyomavirus-induced hemorrhagic cystitis in bone marrow allotransplantation for hematological malignancy following T cell depletion and cyclosporine.
abstract: Nine of 56 (20% actuarial) patients receiving a T cell-depleted, HLA-identical sibling BMT for hematological malignancy developed hemorrhagic cystitis (HC) 15-368 days post BMT. Hematuria was severe and prolonged (median duration 18 days). In eight patients (89%), a viral etiology was confirmed (four adenovirus, four polyomavirus). HC was associated with significant morbidity, with all patients requiring continuous bladder irrigation and transfusion support for blood loss and thrombocytopenia. HC occurring before day 100 was significantly associated with a reduction in long-term survival: 1/7 (14.3%) patients developing HC before day 100 became long-term survivors vs 21/49 (42.8%) without HC by day 100 (P = 0.034). In univariate analysis, HC was associated with a diagnosis of multiple myeloma (P = 0.02). There was a trend towards a higher incidence of HC in patients reactivating cytomegalovirus (CMV) compared with those remaining CMV negative (18.4 vs 5.5% respectively, P = 0.17). HC was not associated with graft-versus-host disease, or with the transplant dose of CD34+ progenitors or CD3+ cells, patient age or sex. Life-threatening, viral-induced HC and the unusually high incidence of adenovirus-induced HC may have been caused by immune deficiency associated with T cell depletion in this series.
authors.affiliation: Bone Marrow Transplant Unit, Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: R
authors.initials: R
authors.lastname: Childs
authors.forename: C
authors.initials: C
authors.lastname: Sanchez
authors.forename: H
authors.initials: H
authors.lastname: Engler
authors.forename: J
authors.initials: J
authors.lastname: Preuss
authors.forename: S
authors.initials: S
authors.lastname: Rosenfeld
authors.forename: C
authors.initials: C
authors.lastname: Dunbar
authors.forename: F
authors.initials: F
authors.lastname: van Rhee
authors.forename: M
authors.initials: M
authors.lastname: Plante
authors.forename: S
authors.initials: S
authors.lastname: Phang
authors.forename: A J
authors.initials: AJ
authors.lastname: Barrett
mesh_terms: D000257:Adenoviridae Infections / Q000150:complications; D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000276:immunology; D002648:Child; D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects*; D003556:Cystitis / Q000209:etiology*; D005260:Female; D019337:Hematologic Neoplasms / Q000628:therapy*; D006470:Hemorrhage / Q000209:etiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D008212:Lymphocyte Depletion / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D027601:Polyomavirus Infections / Q000150:complications; D013601:T-Lymphocytes / Q000276:immunology; D014184:Transplantation, Homologous; D014412:Tumor Virus Infections / Q000150:complications
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine