title: Genetic contribution of the tumor necrosis factor region in Guillain-Barré syndrome.
abstract: We studied genetic polymorphisms in the tumor necrosis factor (TNF) region in 81 Japanese patients with Guillain-Barré syndrome (GBS) and 85 controls. A significantly higher frequency of the 100-base pair (bp) (TNFa2) allele of the TNFa microsatellite marker, which is associated with high TNF alpha production, existed in Campylobacter jejuni-positive (Cj+) GBS patients than in controls, suggesting the involvement of a genetic predisposition to high TNF alpha secretion in the development of C. jejuni-related GBS.
authors.affiliation: Department of Neurology and Clinical Research Center, Utano National Hospital, Kyoto, Japan.
authors.forename: J J
authors.initials: JJ
authors.lastname: Ma
authors.forename: M
authors.initials: M
authors.lastname: Nishimura
authors.forename: H
authors.initials: H
authors.lastname: Mine
authors.forename: S
authors.initials: S
authors.lastname: Kuroki
authors.forename: M
authors.initials: M
authors.lastname: Nukina
authors.forename: M
authors.initials: M
authors.lastname: Ohta
authors.forename: H
authors.initials: H
authors.lastname: Saji
authors.forename: H
authors.initials: H
authors.lastname: Obayashi
authors.forename: H
authors.initials: H
authors.lastname: Kawakami
authors.forename: T
authors.initials: T
authors.lastname: Saida
authors.forename: T
authors.initials: T
authors.lastname: Uchiyama
mesh_terms: D000483:Alleles; D002169:Campylobacter Infections / Q000235:genetics / Q000276:immunology; D016123:Campylobacter jejuni; D017931:DNA Primers; D006801:Humans; D007564:Japan; D018895:Microsatellite Repeats; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011129:Polyradiculoneuropathy / Q000235:genetics*; D012016:Reference Values; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D017931:DNA Primers; D014409:Tumor Necrosis Factor-alpha