[The effect of opportunistic pathogenic microflora in drinking water on the cellular composition of the splenic lymphoid tissue of rats].
In a 6-month study of the morphologic reactions of spleenic immune structures to antigen attacks of varying intensity, one group of Wistar male rats was given water containing 100 opportunistic pathogens per 1 ml, the other, water containing 1,000 opportunistic pathogens per 1 ml. In the control, rats drank sterile water. In the second experimental group, spleenic sites of reproduction reduced the relative count of lymphocytes and mitoticly dividing cells and increased the counts of immature plasmocytes and macrophages. Destructively changed cells grew in number in the mantle, the marginal zone, the lymphoid nodes w/o reproduction sites, PALC and the cellular (lymphoid) aggregation in the red pulp in both experimental groups. There were immature eosinophils in the marginal zone and red pulp cellular aggregations in the second experimental group. Lymphoid nodes w/o reproduction sites and PALC showed a significant reduction in the relative count of middle lymphocytes. Relative counts of middle lymphocytes in the red pulp cellular aggregation as well as plasmocytes and macrophages were on the rise whereas the count of small lymphocytes decreased.
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D000818:Animals; D008214:Lymphocytes / Q000276:immunology; D008221:Lymphoid Tissue / Q000382:microbiology*; D008264:Macrophages / Q000276:immunology; D008297:Male; D008938:Mitosis / Q000502:physiology; D009894:Opportunistic Infections / Q000276:immunology* / Q000382:microbiology*; D051381:Rats; D013154:Spleen / Q000276:immunology* / Q000382:microbiology*; D014871:Water Microbiology
Vliianie uslovno-patogennoĭ mikroflory, soderzhashcheĭsia v pit'tvoĭ vode na kletochnyĭ sostav limfoidnoĭ tkani selezenki krys.