title: Continuous treatment with morphine increases diazepam binding inhibitor mRNA in mouse brain.
abstract: Effects of acute and chronic morphine treatment on the expression of diazepam binding inhibitor (DBI) mRNA in the mouse brain were examined. Cerebral DBI mRNA expression significantly increased in morphine-dependent mice, and this increase is more remarkable in morphine-withdrawn mice, whereas a single administration of morphine (50 mg/kg) produced no changes in the expression. Simultaneous administration of naloxone (3 mg/kg) with morphine completely abolished the increase in cerebral DBI mRNA expression observed in morphine-dependent and -withdrawn mice. These results indicate that a chronic functional interaction between morphine and opioid receptors has a critical role in increases in DBI mRNA expression.
authors.affiliation: Department of Pharmacology, Kawasaki Medical School, Matsushima, Kurashiki, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Katsura
authors.forename: A
authors.initials: A
authors.lastname: Hara
authors.forename: A
authors.initials: A
authors.lastname: Higo
authors.forename: C
authors.initials: C
authors.lastname: Tarumi
authors.forename: Y
authors.initials: Y
authors.lastname: Hibino
authors.forename: S
authors.initials: S
authors.lastname: Ohkuma
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002352:Carrier Proteins / Q000235:genetics*; D026261:Diazepam Binding Inhibitor; D008297:Male; D051379:Mice; D009020:Morphine / Q000008:administration & dosage* / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D009294:Narcotics / Q000008:administration & dosage* / Q000494:pharmacology; D012333:RNA, Messenger / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013997:Time Factors
chemical_list: D002352:Carrier Proteins; D026261:Diazepam Binding Inhibitor; D009292:Narcotic Antagonists; D009294:Narcotics; D012333:RNA, Messenger; D009270:Naloxone; D009020:Morphine