title: Food intake and the presystemic metabolism of single doses of amitriptyline and nortriptyline.
abstract: The influence of food on presystemic metabolism of single doses of amitriptyline (AMI) and nortriptyline (NT) was examined. In randomised order 25 mg tablets of each drug was given to 9 healthy, female volunteers both in the fasting state and together with a standardised breakfast. Concentrations of the drugs and of their dealkylated, hydroxylated and conjugated metabolites were measured by gas chromatography--mass spectrometry (AMI experiment) or high-pressure liquid chromatography (NT experiment). Standard pharmacokinetic parameters were calculated. Food intake did not consistently or significantly influence the bioavailability of either AMI or NT, nor the demethylation of AMI, nor the hydroxylation or the primary or secondary conjugation of NT. There were large interindividual changes in AUC of AMI after food (+94% to -44%). A significant negative correlation between AUC of AMI but not of NT during fasting conditions and per cent change in AUC after food was found (r = -0.72, P = 0.029). The implication of this (negative) correlation for an individual patient might be to keep the intake of the drug in standardised relation to food to avoid undue heavy changes in drug concentration, which might just occur with a change in time relation between intake of drug and food. From a mechanistic view the results argue against a direct and selective influence of food on the presystemic oxidation and conjugation of weakly basic drugs but does not exclude that food may reduce the presystemic metabolism of some such drugs indirectly, by enhancing their rate of hepatic delivery. Presentation of data from food interaction studies should not be restricted to general descriptions. It seems equally important to present the variability of individual data to allow inspection of the extent and direction of effects. This should be of interest for patient, prescriber as well as the regulatory agency.
authors.affiliation: Department of Community Medicine, Malmö University Hospital, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Liedholm
authors.forename: A
authors.initials: A
authors.lastname: Lidén
mesh_terms: D000328:Adult; D000639:Amitriptyline / Q000378:metabolism*; D004435:Eating; D005260:Female; D018565:Food-Drug Interactions; D006801:Humans; D008875:Middle Aged; D009661:Nortriptyline / Q000378:metabolism*
chemical_list: D000639:Amitriptyline; D009661:Nortriptyline