Intrahippocampal D-cycloserine improves MK-801-induced memory deficits: radial-arm maze performance in rats.
In order to investigate whether strychnine-insensitive glycine sites coupled with hippocampal NMDA (N-methyl-d-aspartate) receptors are involved in spatial memory in rats, we examined the effects of intrahippocampal treatment of d-cycloserine (DCS), a glycine-site agonist, on spatial-memory deficits which were produced by an NMDA antagonist MK-801 (dizocilpine) on the radial-arm maze task. After the acquisition of this task, the radial-maze performance was tested under the combined treatments of intraperitoneal MK-801 or saline (SAL) and intrahippocampal DCS or SAL. The results showed that MK-801 impaired the performance, and that DCS improved the MK-801-induced performance impairment. These results suggest that glycine sites are involved in spatial memory through their modulatory action on hippocampal NMDA receptors.
Kawabe
K
K
CREST, Japan Science and Technology Corporation, Japan.
Yoshihara
T
T
Ichitani
Y
Y
Iwasaki
T
T
D000704:Analysis of Variance; D000818:Animals; D003523:Cycloserine / Q000494:pharmacology*; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects*; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D008569:Memory Disorders / Q000175:diagnosis*; D051381:Rats; D017208:Rats, Wistar; D013237:Stereoisomerism
D018691:Excitatory Amino Acid Antagonists; D016291:Dizocilpine Maleate; D003523:Cycloserine