title: Metastasizing mixed tumor of the parotid gland: a rare tumor with unusually rapid progression in a cardiac transplant recipient.
abstract: We report the case of a 69-year-old man who had a mixed tumor (pleomorphic adenoma) removed from his parotid gland 3 years after orthotopic heart transplantation. Two years later, he presented with widely metastatic mixed tumor, which resulted in his death within 6 months. Metastatic mixed tumor is histologically identical to a benign mixed tumor, but it inexplicably metastasizes. Such tumors are rare and have not been reported to date in a transplant recipient. This case illustrates the rapid and aggressive course that malignancies can follow in an immunosuppressed population. Mixed tumors are common salivary neoplasms, so transplant recipients should be carefully followed after resection for evidence of metastatic spread.
authors.affiliation: Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. glwinters@bics.bwh.harvard.edu
authors.forename: B A
authors.initials: BA
authors.lastname: Sampson
authors.forename: J A
authors.initials: JA
authors.lastname: Jarcho
authors.forename: G L
authors.initials: GL
authors.lastname: Winters
mesh_terms: D008949:Adenoma, Pleomorphic / Q000473:pathology*; D000368:Aged; D018450:Disease Progression; D017809:Fatal Outcome; D016027:Heart Transplantation; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary*; D008297:Male; D012468:Salivary Gland Neoplasms / Q000473:pathology*