title: [Value of the conjunctival provocation test in evaluating the activity of 2 concentrations of anti-allergy eyedrops, mequitazine].
abstract: OBJECTIVE
  To compare the activity of topical 0.05% and 0.01% mequitazine versus vehicle in the prevention of allergic conjunctivitis induced by a conjunctival provocation test with allergens.
  
  
  METHODS
  Forty subjects with a history of grass pollen allergic conjunctivitis were enrolled in this comparative, randomized, double-masked study. Fifteen minutes before the conjunctival provocation test, subjects received one instillation alone of 0.05% mequitazine eyedrops in one eye and in the fellow eye either one drop of 0.01% dose or vehicle, at the same dosage. Then a specific conjunctival provocation test (CPT) was performed with the allergen threshold concentration previously defined. The therapeutic efficacy was assessed by the decrease in a symptomatic composite score representing the allergic reaction.
  
  
  RESULTS
  Topical mequitazine at the dose of 0.05% significantly decreases the intensity of the allergic reaction compared to vehicle. Moreover, the group treated with this dose needed a higher allergen concentration to trigger ocular signs. The 0.01% dose appears efficient only on itching, compared to vehicle.
  
  
  CONCLUSIONS
  The results of this study support the efficacy and the onset of action of 0.05% mequitazine eyedrops versus 0.01% or vehicle in the prevention of allergic conjunctivitis induced by a conjunctival provocation test.
authors.affiliation: Laboratoire Chauvin, Département Médical, Montpellier.
authors.forename: O
authors.initials: O
authors.lastname: Dupin
authors.forename: S
authors.initials: S
authors.lastname: Compeyre
authors.forename: C
authors.initials: C
authors.lastname: Trinquand
authors.forename: L
authors.initials: L
authors.lastname: Persi
authors.forename: B
authors.initials: B
authors.lastname: Arnaud
mesh_terms: D000328:Adult; D000485:Allergens; D003233:Conjunctivitis, Allergic / Q000175:diagnosis / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006634:Histamine H1 Antagonists / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D008297:Male; D009883:Ophthalmic Solutions; D010640:Phenothiazines / Q000008:administration & dosage* / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D000485:Allergens; D006634:Histamine H1 Antagonists; D009883:Ophthalmic Solutions; D010640:Phenothiazines; C006069:mequitazine
vernacular_title: Intérêt du Test de Provocation Conjonctivale (TPC) dans l'évaluation de l'activité de deux concentrations d'un collyre anti-allergique, la méquitazine.