[Tetrodotoxin effect on spontaneous and evoked impulse activity of leech Retzius neurons].
Investigation into the Retzius neuron response to synaptic low-, medium-, and high-frequency stimulation under the block of the TTX-sensitive sodium inflow channels, was performed in leeches. The TTX block affected the spontaneous unit activity and not the evoked activity, it altered the responses to low-frequency stimulation (sensitisation) and eliminated the responses to high-frequency activation (habituation). The findings suggest the fundamental plastic properties of the Retzius neurons to depend on functional characteristics of the TTX-sensitive sodium channels.
Sergeeva
S S
SS
Pavlov Institute of Physiology of the Russian Acad. Sci., St. Petersburg, Russia.
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D007865:Leeches / Q000502:physiology*; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D015222:Sodium Channels / Q000187:drug effects / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology; D013779:Tetrodotoxin / Q000494:pharmacology*
D015222:Sodium Channels; D013779:Tetrodotoxin
Effekt tetrodotoksina na fonovuiu i vyzvannuiu impul'snuiu aktivnost' neĭrona Rettsiusa piiavki.