title: Huge fetal sacrococcygeal teratoma with a completely formed eye and intratumoral DNA ploidy heterogeneity.
abstract: Preterm infants and newborns with sacrococcygeal teratomas are at high risk for prenatal and perinatal complications. The prognosis depends on size and histology of the tumor, degree of prematurity, associated malformations, route of delivery, and prompt and complete surgical removal. Virtually any tissue can be present in a sacrococcygeal teratoma, but to date, ocular lens has been documented only as lentinoids (lens-like cells), whereas flow-cytometric data have been variably interpreted. We describe a case of a sacrococcygeal teratoma in an infant of 29 weeks gestational age that is remarkable for the weight (4500 g), the presence of a completely formed eye, and intratumoral DNA ploidy heterogeneity.
authors.affiliation: Institute of Pathology, University of Heidelberg, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Sergi
authors.forename: V
authors.initials: V
authors.lastname: Ehemann
authors.forename: B
authors.initials: B
authors.lastname: Beedgen
authors.forename: O
authors.initials: O
authors.lastname: Linderkamp
authors.forename: H F
authors.initials: HF
authors.lastname: Otto
mesh_terms: D002828:Choristoma / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D004247:DNA / Q000737:chemistry; D005123:Eye; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D005434:Flow Cytometry; D005865:Gestational Age; D006238:Haploidy; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D011296:Prenatal Diagnosis; D012445:Sacrococcygeal Region; D013724:Teratoma / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology
chemical_list: D004247:DNA