Antiviral activity of cholesteryl esters of cinnamic acid derivatives.
Cholesteryl 3",4"-dimethoxycinnamate (7) and a new synthesized o-coumaroyl ester of 3 beta-(2'-hydroxyethoxy)-cholest-5-en (13) exhibited a marked activity against poliovirus type 1 (Mahoney). Compound 7 showed an approximately 20-fold greater selectivity in its antiviral activity than compound 13. These compounds were selected from thirteen steryl esters of cinnamic acid derivatives through an in vitro antiviral screening against viruses belonging to taxonomic groups with causative agents of important human infectious diseases to which chemotherapy is indicated, i.e. Picornaviridae, Orthomyxoviridae, Paramyxoviridae and Herpesviridae.
Galabov
A S
AS
Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria. GALABOV@BGEARN.ACAD.BG
Nikolaeva
L
L
Todorova
D
D
Milkova
T
T
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002788:Cholesterol Esters / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002934:Cinnamates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006564:Herpesviridae / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009975:Orthomyxoviridae / Q000187:drug effects; D010252:Paramyxoviridae / Q000187:drug effects; D010849:Picornaviridae / Q000187:drug effects; D017955:Poliovirus / Q000187:drug effects; D013329:Structure-Activity Relationship; D014777:Virus Diseases
D000998:Antiviral Agents; D002788:Cholesterol Esters; D002934:Cinnamates