A morphological study of Schwann cells and axonal regeneration in chronically transected human peripheral nerves.
Relatively little is known about the effects of chronic transection on human peripheral nerves. In this study intraoperative biopsies were obtained from proximal and distal nerve stumps and intervening neuromas resected before peripheral nerve reconstruction. Biopsies were collected from ten patients following differing types of nerve injury, with delays to repair ranging from 8 to 53 months. Nerves were examined by light and electron microscopy. In general, reinnervation was poor, although even following the most severe injuries, all of the distal stumps contained some regrowing axons, which were always associated with Schwann cells. Denervated Schwann cells, arranged in typical bands of Büngner were consistently present in each distal stump. Our findings confirm that the morphology of chronically denervated human peripheral nerves is essentially similar to that described in experimental models.
Terenghi
G
G
Blond McIndoe Centre, East Grinstead, UK. terenghi@dial.pipex.com
Calder
J S
JS
Birch
R
R
Hall
S M
SM
D000293:Adolescent; D000328:Adult; D001369:Axons / Q000473:pathology* / Q000502:physiology; D001706:Biopsy; D002470:Cell Survival; D003094:Collagen / Q000032:analysis; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D008297:Male; D008475:Median Nerve / Q000293:injuries* / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D008854:Microscopy, Electron; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology / Q000502:physiology; D009416:Nerve Regeneration / Q000502:physiology*; D009463:Neuroma / Q000473:pathology; D010524:Peripheral Nervous System Neoplasms / Q000473:pathology; D009418:S100 Proteins / Q000032:analysis; D012583:Schwann Cells / Q000473:pathology* / Q000502:physiology; D013997:Time Factors
D009418:S100 Proteins; D003094:Collagen