title: Effects of a sympathetic activation by a lower body negative pressure on glucose and lipid metabolism.
abstract: The effects of a sympathetic activation elicited by a lower body negative pressure (LBNP) (at -15 mmHg for 75 min) were assessed in 7 healthy subjects on two occasions: (i) in post-absorptive conditions, and (ii) during glucose infusion (22.2 mumol kg-1 min-1). LBNP increased plasma norepinephrine concentration and heart rate. It did not alter whole-body glucose metabolism (measured with [6,6-2H]glucose) and glycerol turnover (measured with [1,1,2,3,3-2H]glycerol). Interstitial glycerol concentrations were monitored with microdialysis in subcutaneous adipose tissue and in skeletal muscle. LBNP increased dialysate glycerol concentrations in muscle by 16% (P < 0.03) but not in adipose tissue in post-absorptive conditions, and by 37% in adipose tissue (P < 0.05) but not in muscle during glucose infusion. These results indicate that an LBNP-induced sympathetic activation (i) does not increase endogenous glucose production, and (ii) induces only a slight stimulation of lipolysis in adipose tissue during glucose infusion.
authors.affiliation: Institute of Physiology, Faculty of Medicine, University of Lausanne, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Henry
authors.forename: L
authors.initials: L
authors.lastname: Trueb
authors.forename: C
authors.initials: C
authors.lastname: Sartori
authors.forename: U
authors.initials: U
authors.lastname: Scherrer
authors.forename: E
authors.initials: E
authors.lastname: Jéquier
authors.forename: L
authors.initials: L
authors.lastname: Tappy
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D005110:Extracellular Space / Q000378:metabolism; D005947:Glucose / Q000378:metabolism* / Q000494:pharmacology; D005990:Glycerol / Q000378:metabolism / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007262:Infusions, Intravenous; D007328:Insulin / Q000097:blood; D007866:Leg / Q000098:blood supply; D050356:Lipid Metabolism; D008150:Lower Body Negative Pressure; D008297:Male; D009638:Norepinephrine / Q000097:blood; D019518:Postprandial Period; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D005947:Glucose; D005990:Glycerol; D009638:Norepinephrine