Mink lung epithelial cells: unique cell line that supports influenza A and B virus replication.
We have demonstrated for the first time that a mink lung epithelial cell line (Mv1Lu) supports the replication of influenza A and B viruses, including the recently isolated H5N1 avian and human Hong Kong strains, to titers comparable to those in MDCK cells. These results suggest that Mv1Lu cells might serve as an alternative system for the isolation and cultivation of influenza A and B viruses and may be useful for vaccine development.
Schultz-Cherry
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Southeast Poultry Research Laboratory, Agricultural Research Service, U.S. Department of Agriculture, Athens, Georgia 30605, USA. sschultzcherry@sprynet.com
Dybdahl-Sissoko
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McGregor
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Hinshaw
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D000818:Animals; D002460:Cell Line; D004285:Dogs; D004847:Epithelial Cells / Q000821:virology; D009980:Influenza A virus / Q000502:physiology*; D009981:Influenza B virus / Q000502:physiology*; D008168:Lung / Q000821:virology*; D008907:Mink / Q000382:microbiology*; D014779:Virus Replication