Cell-matrix interactions, alterations with aging, involvement in angiogenesis.
Cell-matrix interactions are mediated primarily by integrins, which are membrane-spanning receptors capable of cell or matrix component recognition and involved in two-way intracellular signal transduction. Aging is associated with quantitative and qualitative changes in matrix macromolecules and the integrins that bind them. These changes translate into alterations in cell-matrix interactions. Integrin expression modifications have also been reported in some diseases.
Labat-Robert
J
J
Laboratoire de Recherche Ophthalmologique, Faculté de Médecine Broussais-Hôtel-Dieu, Université Paris.
D000375:Aging / Q000502:physiology*; D000818:Animals; D001161:Arteriosclerosis / Q000473:pathology; D002468:Cell Physiological Phenomena; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D005109:Extracellular Matrix / Q000502:physiology*; D005123:Eye / Q000098:blood supply; D005128:Eye Diseases / Q000473:pathology; D006801:Humans; D009389:Neovascularization, Pathologic; D018919:Neovascularization, Physiologic / Q000502:physiology*; D017469:Receptors, Fibronectin / Q000502:physiology
D017469:Receptors, Fibronectin