Long-term outcome of migraine therapy: predictive value of the frontotemporal nitroglycerin test.
We evaluated whether type of response to the migraine-induction test with a nitroglycerin ointment applied to the frontotemporal head region could predict the efficacy of antimigraine therapy. Forty-two patients with migraine without aura underwent the test before and 2 months after antimigraine therapy. Two and 4 months after treatment withdrawal, most subjects with a negative response to the post-treatment test maintained treatment benefit, whereas benefit was lost in patients with an early onset migraine response.
Bonuso
S
S
Clinica Neurologica, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli Federico II, Naples, Italy.
Di Stasio
E
E
Marano
E
E
de Angelis
S
S
Amato
D
D
Scellini
T
T
Caruso
G
G
D000328:Adult; D005260:Female; D005444:Flunarizine / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D005996:Nitroglycerin; D011433:Propranolol / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use*
D014665:Vasodilator Agents; D011433:Propranolol; D005996:Nitroglycerin; D005444:Flunarizine