title: [Susceptibility to neuro-malaria and HLA-DR alleles in Senegal].
abstract: A prospective study was carried out in 46 patients suffering from severe malaria. The control group included 220 persons of which the HLA-DR distribution was known. The HLA-DRB1 alleles were typed by PCR-SSP (Sequence Specific Primers). The most frequent HLA-DR alleles found in patients group were: DR52 (82.8%), DR13 (57.1%), DR10 (28.6%), DR53 (25.7%), DR3 (20%), DR18 (20%). A significant difference was observed between patients with severe malaria and control group for the following alleles: DR3, DR10, DR13 (p < 0.001; Chi square with Yates' correction) and their relative risk were respectively 14.67; 6.29; 2.84. HLA-DR3 was considered as the major marker associated to severe malaria.
authors.affiliation: Unité d'Immunologie, Institut Pasteur de Dakar, Sénégal.
authors.forename: M
authors.initials: M
authors.lastname: Ndiaye
authors.forename: A
authors.initials: A
authors.lastname: Thiam
authors.forename: R
authors.initials: R
authors.lastname: Ndiaye
authors.forename: G
authors.initials: G
authors.lastname: Angel
authors.forename: P
authors.initials: P
authors.lastname: Seignot
authors.forename: C
authors.initials: C
authors.lastname: Roussilhon
authors.forename: J L
authors.initials: JL
authors.lastname: Sarthou
authors.forename: A
authors.initials: A
authors.lastname: Dieye
mesh_terms: D000328:Adult; D000483:Alleles; D002648:Child; D003128:Coma / Q000209:etiology* / Q000235:genetics / Q000276:immunology / Q000469:parasitology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015600:Glasgow Coma Scale; D006684:HLA-DR Antigens / Q000235:genetics*; D006801:Humans; D016778:Malaria, Falciparum / Q000150:complications* / Q000235:genetics / Q000276:immunology; D008297:Male; D012306:Risk; D012675:Senegal / Q000453:epidemiology
chemical_list: D006684:HLA-DR Antigens
vernacular_title: Susceptibilité au neuropaludisme et allèles HLA-DR au Sénégal.