title: Gastro-oesophageal reflux: the disease of the millennium.
abstract: Gastro-oesophageal reflux disease (GORD) is attributable primarily to acid and bile reflux through the lower oesophageal sphincter. Bile reflux has been implicated in severe oesophagitis, Barrett's oesophagus and oesophageal adenocarcinoma. Developments in evaluating and managing GORD and Barrett's are discussed, with their aetiological role in junctional gastro-oesophageal malignancies.
authors.affiliation: Department of Surgery, Royal Free Hospital, London.
authors.forename: R M
authors.initials: RM
authors.lastname: Navaratnam
authors.forename: M C
authors.initials: MC
authors.lastname: Winslet
mesh_terms: D001471:Barrett Esophagus / Q000209:etiology / Q000473:pathology; D004938:Esophageal Neoplasms / Q000209:etiology / Q000473:pathology; D004941:Esophagitis / Q000209:etiology; D004943:Esophagogastric Junction / Q000473:pathology; D005764:Gastroesophageal Reflux / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D006801:Humans