[Histocompatibility antigens in multiple sclerosis in children].
A phenotyping was done in respect of HLA system in 14 children with documented multiple sclerosis (MS), 20 children with potential MS, and 42 their near relations. HLA-B12 antigen was recordable with high frequency (RR = 6.29; P < 0.025) while HLA-B18 with low one (P < 0.01) as compared to normal subjects both among patients in the general group and in those with proved MS. The latter showed a tendency toward increase in frequency HLA-B7. Children with significant MS where there was an association in the phenotype of HLA-B12 or HLA-B7 with HLA-A3 ran predominantly an aggravating course while their association with HLA-A2 resulted in a more benign course. The results obtained in respect of HLA antigens in MS in children differ from those of other authors on MS in adults.
Efimenko
V N
VN
Evtushenko
S K
SK
Khodakovskiĭ
A V
AV
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics / Q000276:immunology; D006680:HLA Antigens / Q000097:blood*; D015395:Histocompatibility Antigens Class I / Q000097:blood; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000235:genetics / Q000276:immunology*; D010641:Phenotype; D012306:Risk
D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I
Antigeny gistosovmestimosti pri rasseiannom skleroze u deteĭ.