Macromolecular synthesis contributes to nociceptive response to subcutaneous formalin injection in mice.
Subcutaneous formalin injection into the hindpaw produces two phases of nociceptive response: phase 1 and phase 2. Activation of N-methyl-D-aspartate (NMDA) receptors in the spinal cord during phase 1 is important for phase 2. We report here that phase 2 but not phase 1 requires new RNA and protein synthesis in the spinal cord.
Kim
S J
SJ
Department of Anesthesiology, Washington University in St. Louis, MO 63110, USA.
Thomas
K S
KS
Calejesan
A A
AA
Zhuo
M
M
D000704:Analysis of Variance; D000818:Animals; D003609:Dactinomycin / Q000494:pharmacology; D007278:Injections, Spinal; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D019384:Nucleic Acid Synthesis Inhibitors / Q000494:pharmacology; D010146:Pain / Q000503:physiopathology*; D010147:Pain Measurement; D014176:Protein Biosynthesis; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D012313:RNA / Q000096:biosynthesis*; D012018:Reflex / Q000187:drug effects
D019384:Nucleic Acid Synthesis Inhibitors; D011500:Protein Synthesis Inhibitors; D003609:Dactinomycin; D012313:RNA