Calcium-binding proteins and nitric oxide in retinal function and disease.
Regulation of phototransduction in photoreceptor cells occurs via several feedback loops. Some of these circuits involve the neuron-specific Ca2+-binding proteins recoverin and guanylyl cyclase-activating protein. Recent findings suggest that these proteins are also involved in retinal diseases. Another Ca2+-regulated process in the retina is the synthesis of nitric oxide, a substance of potential neurotoxicity. This review discusses several Ca2+-mediated processes in the retina.
Müller
F
F
Institut für Biologische Informationsverarbeitung, Forschungszentrum Jülich, Germany.
Koch
K W
KW
D000818:Animals; D002135:Calcium-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D005136:Eye Proteins; D051604:Guanylate Cyclase-Activating Proteins; D051597:Hippocalcin; D006801:Humans; D008074:Lipoproteins; D009419:Nerve Tissue Proteins; D017942:Nitric Acid / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism; D052248:Nitric Oxide Synthase Type I; D051603:Recoverin; D012160:Retina / Q000378:metabolism* / Q000473:pathology; D012162:Retinal Degeneration / Q000378:metabolism* / Q000473:pathology; D014785:Vision, Ocular / Q000502:physiology
D002135:Calcium-Binding Proteins; D005136:Eye Proteins; C496736:GUCA1A protein, human; D051604:Guanylate Cyclase-Activating Proteins; D008074:Lipoproteins; D009419:Nerve Tissue Proteins; C496731:RCVRN protein, human; D051603:Recoverin; D051597:Hippocalcin; D017942:Nitric Acid; C496320:NOS1 protein, human; D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I