[Antithrombotic effect of catalase and chondroitin sulfate derivatives in arterial damage in rats].
The antithrombotic action of catalase and chondroitin sulfate derivatives was studied on the rat arterial thrombosis induced by treatment of vessel with ferrous chloride solution. The effect of native or chondroitin sulfate modified catalase, as well as the mixture of native catalase and free chondroitin sulfate in ratio which is equal to their content in conjugate was compared in respect to corresponding doses according to active catalase content. The antithrombotic action of conjugate and its component mixture is rather similar with each other and significantly exceeds the effect of native enzyme. The conjugate was the most effective in respect to retarding/prevention of arterial occlusion. The action of catalase preparations was altered the thrombus structure conducting blood stream retention at the low doses used. The directions of further studies of antithrombotic activity for catalase, superoxide dismutase and chondroitin sulfate derivatives were founded.
Maksimenko
A V
AV
Institute of Experimental Cardiology, Russian Cardiology Research Center, Moscow, Russia.
Tishchenko
E G
EG
Golybykh
V L
VL
D000818:Animals; D001158:Arteries / Q000473:pathology*; D002374:Catalase / Q000737:chemistry / Q000627:therapeutic use*; D002809:Chondroitin Sulfates / Q000737:chemistry / Q000627:therapeutic use*; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D051381:Rats; D013927:Thrombosis / Q000188:drug therapy*
D005343:Fibrinolytic Agents; D002809:Chondroitin Sulfates; D002374:Catalase
Antitromboticheskoe deĭstvie proizvodnykh katalazy i khondroitinsul' fata pri arterial'nom porazhenii u krys.