Therapeutic implications of interleukin-10 in surgical disease.
Pharmacological therapy of surgical disease often involves manipulating the physiologic balance between pro- and anti-inflammatory responses. Many agents target only one aspect of the inflammatory cascade. Originally identified as a protein elaborated by T-lymphocytes, IL-10 appears to globally inhibit cytokine production. The purpose of this manuscript is to examine the immunomodulatory and anti-inflammatory effects of interleukin-10 (IL-10) in an attempt to define the clinical utility of IL-10, both as a marker of and as a therapeutic strategy for intervention in inflammatory and immune-mediated diseases. IL-10 is elaborated from multiple sources and has diverse cellular effects to regulate immune and inflammatory responses. Accumulating evidence suggests that the anti-inflammatory influence of IL-10 observed at the cellular level may be manipulated to impact the immune and inflammatory-mediated responses associated with injury and sepsis, gastrointestinal and cardiovascular disease, and transplantation. In conclusion, IL-10 is an important mediator of immune and anti-inflammatory responses in surgical disease and, as such, has therapeutic promise as an immunomodulator and as an anti-inflammatory agent.
Selzman
C H
CH
Department of Surgery, University of Colorado Health Sciences Center and The Veterans Affairs Hospital, Denver 80262, USA. craig.selzman@UCHSC.edu
Shames
B D
BD
Miller
S A
SA
Pulido
E J
EJ
Meng
X
X
McIntyre
R C
RC
Harken
A H
AH
D000818:Animals; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism; D016753:Interleukin-10 / Q000494:pharmacology* / Q000502:physiology*; D010195:Pancreatitis / Q000188:drug therapy / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D050796:STAT3 Transcription Factor; D018805:Sepsis / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D015534:Trans-Activators / Q000378:metabolism; D014158:Transcription, Genetic; D014180:Transplantation; D014947:Wounds and Injuries / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism*
D016207:Cytokines; D004268:DNA-Binding Proteins; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; D015534:Trans-Activators; D016753:Interleukin-10; D011505:Protein-Tyrosine Kinases