title: Application of a standardized cytomegalovirus antigenemia assay in the management of patients with AIDS.
abstract: One-hundred twenty AIDS patients, tested by an optimized cytomegalovirus antigenemia (CMV-Ag) assay, were followed over a 6-month period in an attempt to correlate viral (CMV) load with severe CMV organ-specific disease. Among patients available for follow-up, CMV organ-specific disease was present in seven of eight (88%) with pp65 antigen levels > or = 50 cells per 4 x 10(5) polymorphonuclear leukocytes. One-hundred six patients of 107 patients with levels < 50 pp65 reactive cells did not develop CMV organ-specific disease within our 6-month follow-up period. The CMV-Ag assay, as standardized in our clinical setting, served as a marker and predictor of CMV organ-specific disease in our AIDS patient population.
authors.affiliation: Jane and Dayton Brown and Dayton T. Brown Jr. Virology Laboratory, North Shore University Hospital, New York University School of Medicine, Manhasset, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Lipson
authors.forename: M E
authors.initials: ME
authors.lastname: Match
authors.forename: A I
authors.initials: AI
authors.lastname: Toro
authors.forename: M H
authors.initials: MH
authors.lastname: Kaplan
authors.forename: D H
authors.initials: DH
authors.lastname: Shepp
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis* / Q000821:virology; D003587:Cytomegalovirus / Q000276:immunology / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000175:diagnosis* / Q000821:virology; D003588:Cytopathogenic Effect, Viral; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D008297:Male; D010750:Phosphoproteins / Q000097:blood*; D016133:Polymerase Chain Reaction / Q000379:methods; D019562:Viral Load; D014776:Virus Cultivation
chemical_list: D010750:Phosphoproteins