Beta-chemokines MCP-1 and RANTES are selectively increased in cerebrospinal fluid of patients with human immunodeficiency virus-associated dementia.
Human immunodeficiency virus-associated dementia (HAD) is associated with increased numbers of activated central nervous system (CNS) macrophages. Chemokines, which regulate infiltration of macrophages, were measured in the cerebrospinal fluid (CSF) of human immunodeficiency virus (HIV)-negative and HIV-positive individuals with and without neurological disease. Monocyte chemotactic protein (MCP)-1 and RANTES (but not MCP-3), macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, or interleukin-8 (IL-8) was higher in HAD. MCP-1 correlated with CSF viral load and severity of dementia, and it increased over time in patients who developed dementia.
Kelder
W
W
Department of Molecular Microbiology and Immunology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA.
McArthur
J C
JC
Nance-Sproson
T
T
McClernon
D
D
Griffin
D E
DE
D015526:AIDS Dementia Complex / Q000134:cerebrospinal fluid* / Q000276:immunology; D018932:Chemokine CCL2 / Q000134:cerebrospinal fluid*; D018946:Chemokine CCL5 / Q000134:cerebrospinal fluid*; D054410:Chemokine CCL7; D003430:Cross-Sectional Studies; D016207:Cytokines; D018023:HIV Seronegativity / Q000276:immunology; D006679:HIV Seropositivity / Q000134:cerebrospinal fluid* / Q000276:immunology; D006801:Humans; D016209:Interleukin-8 / Q000134:cerebrospinal fluid; D018945:Monocyte Chemoattractant Proteins / Q000134:cerebrospinal fluid
C515450:CCL7 protein, human; D018932:Chemokine CCL2; D018946:Chemokine CCL5; D054410:Chemokine CCL7; D016207:Cytokines; D016209:Interleukin-8; D018945:Monocyte Chemoattractant Proteins