[Insulin-dependent diabetes in Senegal: HLA-DR combinations according to age of onset and sex].
In insulin-dependent diabetes mellitus, HLA-DR markers are involved, namely DR3, DR4 and DR9 alleles, among black senegalese populations. Studying the different associations of these alleles showed a strong predisposition to insulin-dependent diabetes mellitus with DR3/4 (p > 10(-2); OR = 13.6); DR4/9 (p < 10(-2); OR = 8.32) and DR9/9 (p < 0.05; OR = 7.78). And then it was observed a tendency to an inverse relationship of DR3/4 frequency with age of onset in male patients.
Cisse
A
A
Laboratoire de Physique Pharmaceutique, Faculté de Médecine, de Pharmacie et d'Odontostomatologie, Université Cheikh Anta DIOP, Dakar, Sénégal.
Chauffert
M
M
Diop
S N
SN
Chevenne
D
D
Sidibe
E H
EH
Michel
S
S
Sow
A M
AM
Trivin
F
F
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000483:Alleles; D001327:Autoimmune Diseases / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D044383:Black People / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006684:HLA-DR Antigens / Q000235:genetics*; D006801:Humans; D008297:Male
D006684:HLA-DR Antigens
Le diabète insulino-dépendant en milieu Sénégalais: combinaisons HLA-DR en fonction de l'âge d'installation et du sexe.