Involvement of macrophage scavenger receptors in protection against murine malaria.
Macrophage scavenger receptor A (MSR-A) deficient mice MSR-A(-/-) were infected by the intraperitoneal injection of the Plasmodium berghei NK65 strain in the erythrocytic stage. The MSR-A(-/-) mice died significantly earlier than the control mice (P=0.060). In the surviving mice, two peaks of parasitemia were observed: the first 5-7 days and the second at 2-3 weeks after infection. Death of all MSR-A(-/-) mice occurred at either peak of parasitemia, suggesting that MSR-A protects mice from severe infection. This model may be useful for the study of molecular mechanisms of macrophage functions in malaria infection.
Nogami
S
S
Department of Veterinary Medicine, Nihon University, Fujisawa, Kanagawa, Japan.
Watanabe
J
J
Nakagaki
K
K
Nakata
K
K
Suzuki
H
H
Suzuki
H
H
Fujisawa
M
M
Kodama
T
T
Kojima
S
S
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D008264:Macrophages / Q000276:immunology*; D008288:Malaria / Q000209:etiology / Q000276:immunology* / Q000517:prevention & control*; D051379:Mice; D018345:Mice, Knockout; D018512:Parasitemia / Q000209:etiology / Q000276:immunology / Q000517:prevention & control; D010962:Plasmodium berghei / Q000276:immunology / Q000472:pathogenicity; D011971:Receptors, Immunologic / Q000235:genetics / Q000276:immunology*; D051116:Receptors, Scavenger; D013997:Time Factors
D011971:Receptors, Immunologic; D051116:Receptors, Scavenger