title: The dynamic structure of the germinal center.
abstract: Analysis of germinal centers (GCs) in chronically inflamed human tonsils has led to the dogma that GCs contain two compartments with separate functions: a dark zone where B cells proliferate and hypermutate; and a light zone where selection and differentiation occur. However, here Stephanie Camacho and colleagues discuss immunohistological analysis of splenic GCs arising de novo that reveal a more plastic structure.
authors.affiliation: Deutsches Rheuma ForschungsZentrum, Berlin, Germany. berek@drfz.de
authors.forename: S A
authors.initials: SA
authors.lastname: Camacho
authors.forename: M H
authors.initials: MH
authors.lastname: Kosco-Vilbois
authors.forename: C
authors.initials: C
authors.lastname: Berek
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D000944:Antigens, Differentiation, B-Lymphocyte / Q000032:analysis; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D002455:Cell Division; D002645:Chickens; D003713:Dendritic Cells / Q000276:immunology; D018858:Germinal Center / Q000276:immunology*; D007150:Immunohistochemistry; D051379:Mice; D008807:Mice, Inbred BALB C; D010081:Oxazolone / Q000276:immunology; D019887:Peanut Agglutinin / Q000276:immunology; D017455:Receptors, IgE / Q000032:analysis; D012709:Serum Albumin / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013997:Time Factors
chemical_list: D000911:Antibodies, Monoclonal; D000944:Antigens, Differentiation, B-Lymphocyte; D000945:Antigens, Differentiation, T-Lymphocyte; D019887:Peanut Agglutinin; D017455:Receptors, IgE; D012709:Serum Albumin; D010081:Oxazolone