title: Evolution of the immune response in the central nervous system following infection with Borna disease virus.
abstract: Borna disease virus infection of Lewis rats results in an immune-mediated disease associated with transient meningoencephalitis and persistent viral infection. In the acute phase of disease, perivascular immune cell infiltrates consisted of CD4 + and CD8 + T cells, macrophages and NK cells with peak expression of mRNAs encoding the cytokines IL1alpha, IL2, IL6, TNFalpha, and IFNgamma. In the chronic phase of disease, numbers of NK cells, B cells and activated microglia increased in the brain parenchyma with peak expression of IL4 mRNA. These data were consistent with a switch from a Th1-like, cellular immune response to a Th2-like, humoral immune response.
authors.affiliation: Department of Neurology, University of California, Irvine 92697-4292, USA.
authors.forename: C G
authors.initials: CG
authors.lastname: Hatalski
authors.forename: W F
authors.initials: WF
authors.lastname: Hickey
authors.forename: W I
authors.initials: WI
authors.lastname: Lipkin
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D017209:Apoptosis; D001890:Borna Disease / Q000276:immunology* / Q000473:pathology; D001921:Brain / Q000276:immunology* / Q000473:pathology; D016207:Cytokines / Q000235:genetics; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D011917:Rats, Inbred Lew; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D016207:Cytokines; D012333:RNA, Messenger; D007073:Immunoglobulin E