Dobutamine-induced changes in pulmonary artery pressure in patients with congestive heart failure and their relation to abnormalities of lung diffusing capacity.
Short-term infusion of dobutamine may determine a mild, statistically significant increase in pulmonary artery pressure from baseline in 30% of patients with moderate to severe heart failure despite systemic effects (changes in cardiac index and systemic vascular resistance) similar to those observed in patients showing a large reduction in right heart pressures. The increase in pulmonary artery pressure observed seems to be associated with a lower pulmonary diffusing capacity, probably reflecting a reduction in recruitment and distension capacity of pulmonary circulation.
Faggiano
P
P
Cardiology Division of S. Orsola Hospital, Brescia, Italy.
D'Aloia
A
A
Gualeni
A
A
Ambrosino
N
N
Pagani
M
M
Giordano
A
A
D000328:Adult; D000368:Aged; D002316:Cardiotonic Agents / Q000494:pharmacology*; D004280:Dobutamine / Q000494:pharmacology*; D006333:Heart Failure / Q000209:etiology / Q000503:physiopathology*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D011653:Pulmonary Diffusing Capacity / Q000187:drug effects; D011669:Pulmonary Wedge Pressure / Q000187:drug effects*; D012129:Respiratory Function Tests; D018487:Ventricular Dysfunction, Left / Q000150:complications
D002316:Cardiotonic Agents; D004280:Dobutamine