title: Prevalence of anti-hepatitis C antibodies in a rural community without high mortality from liver disease in Niigata prefecture.
abstract: The prevalence of hepatitis C virus (HCV) infection and factors relating to the HCV transmission were evaluated in a community without high mortality from chronic liver disease in Niigata prefecture. A total of 2,231 subjects were examined to detect anti-HCV core antibodies by enzyme-linked immunosorbent assay with synthetic peptides CP14 and CP9. The prevalence was 1.66% (95% CI; 1.17% to 2.29%) and tended to increase with age. The values were lower than those reported from districts with hepatic disease endemic. Histories of blood transfusion (relative risk (RR) 5.51; 95% CI 2.90 to 10.48) and surgery with hospital admission (RR 4.43; 95% CI 2.04 to 9.65) were significantly associated with the anti-HCV core antibodies positive. Multiple logistic analysis corroborated independency of these factors. Among 188 subjects who experienced surgery and/or blood transfusion after 1990, only one (0.5%) had HCV infection. By contrast, 8 (3.5%) were positive in subjects who experienced first acupuncture therapy after 1990. The acupuncture therapy in alternative medicine could be still related to the HCV transmission.
authors.affiliation: Department of Community and Family Medicine, Jichi Medical School, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kayaba
authors.forename: M
authors.initials: M
authors.lastname: Igarashi
authors.forename: H
authors.initials: H
authors.lastname: Okamoto
authors.forename: F
authors.initials: F
authors.lastname: Tsuda
mesh_terms: D015670:Acupuncture Therapy / Q000009:adverse effects; D005260:Female; D006306:Health Surveys; D016174:Hepacivirus / Q000276:immunology / Q000302:isolation & purification; D019698:Hepatitis C, Chronic / Q000453:epidemiology* / Q000276:immunology; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008107:Liver Diseases / Q000401:mortality; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D012423:Rural Health / Q000706:statistics & numerical data*; D013223:Statistics as Topic