title: Interaction of CCK and 8-OH-DPAT in the satiation of alcohol intake.
abstract: Administration of the neuropeptide cholecystokinin (CCK) is known to reduce food and alcohol intake and preference. The food satiation effect of CCK is reportedly dependent on serotonergic neurotransmission. Administration of 8-OH-DPAT, a serotonin1A autoreceptor agonist, reduces the ability of CCK to inhibit feeding. We determined if CCK's alcohol satiation effect also depends on activity of serotonergic neurons by administering 8-OH-DPAT (120-240 microg/kg) to 23-h water-deprived female and male rats, followed 1 h later by i.p. injection of CCK (4 microg/kg) and 30-min access to 5% w/v ethanol. 8-OH-DPAT significantly (p < 0.05) interacted with CCK, and reduced CCK's ethanol satiation effect when given i.p. but increased CCK's effect when given s.c. Female rats showed this interaction of 8-OH-DPAT with CCK at a higher dose than males when given i.p., but females were more sensitive to s.c. 8-OH-DPAT's ability to reduce ethanol intake. Results are consistent with previous findings of dose-, sex-, and route-dependent biphasic effects of 8-OH-DPAT on feeding and ethanol intake. A partial dependence of CCK's alcohol satiation effect on serotonergic neurotransmission is revealed in this design.
authors.affiliation: Department of Psychology, University of Southern Colorado, Pueblo 81001-4901, USA. kulkosky@meteor.uscolo.edu
authors.forename: P J
authors.initials: PJ
authors.lastname: Kulkosky
authors.forename: C T
authors.initials: CT
authors.lastname: Allison
authors.forename: T G
authors.initials: TG
authors.lastname: Allison
authors.forename: L M
authors.initials: LM
authors.lastname: Marquez
authors.forename: B J
authors.initials: BJ
authors.lastname: Mattson
mesh_terms: D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology*; D000818:Animals; D015259:Dopamine Agents / Q000494:pharmacology*; D004347:Drug Interactions; D004435:Eating / Q000187:drug effects; D000431:Ethanol / Q000008:administration & dosage*; D005260:Female; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012527:Satiation / Q000187:drug effects*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D012727:Sex Characteristics; D012844:Sincalide / Q000494:pharmacology*; D014868:Water Deprivation
chemical_list: D015259:Dopamine Agents; D017366:Serotonin Receptor Agonists; D000431:Ethanol; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D012844:Sincalide