A study on p53 protein and anti-p53 antibodies in the sera of patients with oesophageal cancer.
p53 protein levels were examined in sera of 15 oesophageal cancer patients using the p53 monoclonal antibody Pab 1801. Antibodies specific for p53 were also analyzed in 20 patients (including 15 patients used for p53 protein level study) and 20 healthy controls. Anti-p53 antibodies were present in 30% (6/20) patients while no antibodies were detected in sera of healthy controls. Comparative analysis of the two parameters, i.e., p53 protein levels and the corresponding antibodies in the patients revealed no correlation.
Sobti
R C
RC
Department of Biotechnology, Panjab University, Chandigarh - 160014, India.
Parashar
K
K
D000328:Adult; D000368:Aged; D000906:Antibodies / Q000032:analysis*; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016159:Tumor Suppressor Protein p53 / Q000097:blood* / Q000276:immunology*
D000906:Antibodies; D016159:Tumor Suppressor Protein p53