title: Ultrastructure of the lens epithelium in Alport's syndrome.
abstract: The ultrastructure of the lens epithelium in Alport's syndrome was studied. In a transmission electron-microscopic examination, a large number of tonofilaments, swollen mitochondria, a dilated Golgi complex, a dilated rough endoplasmic reticulum with electron-dense (osmiophilic) material in some of these irregular structures and myelin figures were observed. Most of the cells had regularly shaped and only a few of them irregularly shaped nuclei. Additionally, polymorphism and marked degeneration in the transitional zone were observed in the scanning electron-microscopic examination of the lens epithelium. After the transitional zone, there were no epithelial cells present under the lens capsule, an observation that has never been reported in the literature.
authors.affiliation: Department of Anatomy, Hacettepe University, Faculty of Medicine, Ankara, Turkey.
authors.forename: M F
authors.initials: MF
authors.lastname: Sargon
authors.forename: H H
authors.initials: HH
authors.lastname: Celik
authors.forename: C
authors.initials: C
authors.lastname: Sener
mesh_terms: D000328:Adult; D002386:Cataract / Q000209:etiology / Q000473:pathology; D002387:Cataract Extraction; D002455:Cell Division; D002467:Cell Nucleus / Q000648:ultrastructure; D018870:Endoplasmic Reticulum, Rough / Q000648:ultrastructure; D004848:Epithelium / Q000648:ultrastructure; D006056:Golgi Apparatus / Q000648:ultrastructure; D006801:Humans; D007382:Intermediate Filaments / Q000648:ultrastructure; D007903:Lens Capsule, Crystalline / Q000648:ultrastructure; D007908:Lens, Crystalline / Q000648:ultrastructure*; D008297:Male; D008855:Microscopy, Electron, Scanning; D008928:Mitochondria / Q000648:ultrastructure; D009394:Nephritis, Hereditary / Q000150:complications / Q000473:pathology*