Extracts from various mite species contain cross-reactive and noncross-reactive IgE epitopes. A RAST inhibition study.
Previous studies have demonstrated the high incidence of Dermatophagoides, Euroglyphus, Blomia, Lepidoglyphus and Chortoglyphus spp. sensitizations in a mite-allergic population. The aim of this study was to evaluate immunological cross-reactivity among the above mentioned groups, using sera from a nonrural population allergic to mites, from a subtropical area (Canary Islands). RAST inhibition studies demonstrated significant cross-reactivity among Dermatophagoides and Euroglyphus species (> or = 65% of maximum theoretical inhibition), as also noted by other authors. Blomia kulagini demonstrated scarce cross-reactivity with Dermatophagoides, Lepidoglyphus and Chortoglyphus species (< or = 30% of maximum theoretical inhibition) and medium level with Euroglyphus maynei (45% of maximum theoretical inhibition). Chortoglyphus arquatus demonstrated high cross-reactivity levels with the other species studied. The results obtained in this study demonstrated the scarce immunological cross-reactivity between Pyroglyphidae and non-Pyroglyphidae mites, thus suggesting the polysensitization of the studied population to different mite species.
García-Robaina
J C
JC
Dept. of Allergy, Hospital Nuestra Sra. Candelaria, Tenerife, Spain.
Eraso
E
E
De la Torre
F
F
Guisantes
J
J
Martínez
A
A
Palacios
R
R
Martínez
J
J
D000293:Adolescent; D000328:Adult; D000485:Allergens / Q000276:immunology; D000818:Animals; D002648:Child; D003429:Cross Reactions / Q000276:immunology; D000939:Epitopes / Q000276:immunology*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology*; D008297:Male; D008925:Mites / Q000276:immunology*; D011852:Radioallergosorbent Test; D013045:Species Specificity
D000485:Allergens; D000939:Epitopes; D007073:Immunoglobulin E