Serological and molecular analysis of HLA class I and II alleles in Thai patients with psoriasis vulgaris.
The HLA class I and class II alleles in 67 patients with type I psoriasis vulgaris, 23 patients with type II psoriasis vulgaris and 140 healthy individuals were analyzed. The frequencies of HLA-A2, -B46, -B57 and DQB1*0303 were significantly increased in type I psoriasis compared to the controls (Pc<0.05). Molecular analysis of HLA-A2 alleles showed an increase in HLA-A*0207 and a decrease in HLA-A*0203 in type I psoriasis. HLA-DQB1*0301 was significantly decreased in type I psoriasis compared to the normal controls (Pc<0.05). No association of any alleles with type II psoriasis was observed. This data demonstrated two susceptible haplotypes: HLA-A1-B57-DRB1*0701-DQA1*0201-DQB1*0303 (AH57.1) and HLA-A2-B46-DRB1*0901-DQA1*0301-DQB1*0303 (AH46.1) for type I psoriasis in the Thai population. Besides, the haplotype AH46.1 was also associated with type II psoriasis.
Vejbaesya
S
S
Department of Transfusion Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Eiermann
T H
TH
Suthipinititharm
P
P
Bancha
C
C
Stephens
H A
HA
Luangtrakool
K
K
Chandanayingyong
D
D
D000328:Adult; D000483:Alleles; D005805:Genes, MHC Class I / Q000235:genetics*; D005802:Genes, MHC Class II / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D015789:HLA-A2 Antigen / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics; D006683:HLA-DQ Antigens / Q000235:genetics; D059866:HLA-DQ beta-Chains; D006239:Haplotypes; D006801:Humans; D011565:Psoriasis / Q000453:epidemiology / Q000235:genetics*; D013785:Thailand / Q000453:epidemiology
D015789:HLA-A2 Antigen; D015235:HLA-B Antigens; C080311:HLA-B46 antigen; C103707:HLA-B57 antigen; D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen