In vivo effects of CHOP protocol on onco and suppressor gene expression: follow-up study.
In vivo investigation of onco/suppressor gene effects may provide new findings concerning chemical carcinogenesis. In earlier studies we pointed out the carcinogenic potential of COPP and ABVD chemotherapeutical protocols in "long-term" experiments. In another follow up study we proved the connection between the early gene expression changes and the late consequences of COPP and ABVD treatment during, a one year latency period. CHOP protocol is containing both proved carcinogenic cyclophosphamide and highly mutagenic doxorubicyn. CHOP protocol in "short-term" experiments shows strong effect on Ha-ras oncogene expression.
Ember
I
I
Department of Preventive Medicine, University Medical School of Pécs, Hungary.
Kiss
I
I
Raposa
T
T
Nowrasteh
G
G
Matolcsy
A
A
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology*; D003520:Cyclophosphamide / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology; D005260:Female; D015870:Gene Expression / Q000187:drug effects; D016259:Genes, myc / Q000187:drug effects* / Q000235:genetics; D016158:Genes, p53 / Q000187:drug effects* / Q000235:genetics; D011905:Genes, ras / Q000187:drug effects* / Q000235:genetics; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D015689:Oncogene Protein p21(ras) / Q000378:metabolism; D016274:Oncogene Protein p55(v-myc) / Q000378:metabolism; D011241:Prednisone / Q000494:pharmacology; D012313:RNA / Q000378:metabolism; D013154:Spleen / Q000187:drug effects*; D013950:Thymus Gland / Q000187:drug effects*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D014750:Vincristine / Q000494:pharmacology
D016274:Oncogene Protein p55(v-myc); D016159:Tumor Suppressor Protein p53; D014750:Vincristine; D012313:RNA; D004317:Doxorubicin; D003520:Cyclophosphamide; D015689:Oncogene Protein p21(ras); D011241:Prednisone