title: Genetic variation in paraoxonase-2 is associated with variation in plasma lipoproteins in Canadian Oji-Cree.
abstract: We report studies of the association between genetic variation in PON2 and variation in plasma quantitative traits in a sample of 334 non-diabetic Oji-Cree. We detected associations between PON2 variation in codon 148 (Ala --> Gly) and variation in fasting plasma concentrations of total and low-density lipoprotein (LDL) cholesterol and apolipoprotein (apo) B. In particular, homozygotes for a PON2 allele that encoded A148 had significantly higher plasma total, LDL cholesterol and apo B than subjects having the other two genotypes (p < 0.01). Taken together, our results suggest that common genetic variation on chromosome 7q21.3-22.1 in PON2 is associated with significant variation of intermediate traits in plasma lipoprotein metabolism.
authors.affiliation: John P Robarts Research Institute, University of Western Ontario, London, Canada. robert.hegele@rri.on.ca
authors.forename: R A
authors.initials: RA
authors.lastname: Hegele
authors.forename: S B
authors.initials: SB
authors.lastname: Harris
authors.forename: P W
authors.initials: PW
authors.lastname: Connelly
authors.forename: A J
authors.initials: AJ
authors.lastname: Hanley
authors.forename: L C
authors.initials: LC
authors.lastname: Tsui
authors.forename: B
authors.initials: B
authors.lastname: Zinman
authors.forename: S W
authors.initials: SW
authors.lastname: Scherer
mesh_terms: D000328:Adult; D000483:Alleles; D043303:Aryldialkylphosphatase; D002170:Canada; D004950:Esterases / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D010641:Phenotype
chemical_list: D008074:Lipoproteins; D004950:Esterases; D043303:Aryldialkylphosphatase; C468411:PON2 protein, human