In vitro activity of the new ketolide HMR3647 in comparison with those of macrolides and pristinamycins against Enterococcus spp.
Ninety-four erythromycin-susceptible and 107 erythromycin-resistant enterococcal strains (MIC of >/=512 microgram/ml) were inhibited by the ketolide HMR3647 at MICs of </=0.007 to 0.06 and 0.03 to 8 microgram/ml, respectively. Eighteen vanA-positive isolates and 29 high-level-penicillin-resistant isolates, all of them erythromycin resistant, were inhibited by HMR3647 at an MIC range of 0.015 to 4 microgram/ml. The new ketolide has excellent activity against Enterococcus species.
Torres
C
C
Area de Bioquímica y Biología Molecular, Universidad de La Rioja, Logroño, Spain. carmen.torres@daa.unirioja.es
Zarazaga
M
M
Tenorio
C
C
Portillo
A
A
Saenz
Y
Y
Ruiz
F
F
Baquero
F
F
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D016983:Enterococcus / Q000187:drug effects* / Q000235:genetics; D004917:Erythromycin / Q000494:pharmacology; D048628:Ketolides; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D010641:Phenotype; D014769:Virginiamycin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D048628:Ketolides; D018942:Macrolides; D014769:Virginiamycin; D004917:Erythromycin; C106791:telithromycin