Pharmacological effects of BAM-1120, a novel ergoline derivative, on central dopaminergic functions in rats.
BAM-1120, an ergoline derivative, has been found to display a relatively high affinity for dopamine D2-like receptor subtypes in a preliminary binding study. This study investigated whether BAM-1120 acts as a dopamine receptor agonist on prolactin-secreting and motor functions. BAM-1120 suppressed hyperprolactinemia induced by pretreatment with reserpine or estradiol in female rats. Furthermore, BAM-1120 was able to shrink a prolactin-secreting pituitary tumor (prolactinoma) in the estradiol-treated female rats. BAM-1120 induced rotations contralateral to the lesion side in rats with unilateral 6-hydroxydopamine-induced lesions of nigrostriatal dopamine pathway at a dose that was at least 30-fold higher than that required for the inhibition of prolactin secretion. These findings suggest that BAM-1120 is characterized as a putative dopamine D2-like receptor agonist that possesses a preference of inhibiting prolactin secretion over activating motor behaviors.
Ichihara
K
K
New Drug Research Laboratories, Maruko Seiyaku Co., Ltd., Kasugai, Japan.
Kamei
H
H
Okumura
K
K
Mizukoshi
K
K
Nagasaka
M
M
D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology; D004298:Dopamine / Q000502:physiology*; D015259:Dopamine Agents / Q000494:pharmacology*; D018491:Dopamine Agonists / Q000494:pharmacology; D004873:Ergolines / Q000494:pharmacology*; D004958:Estradiol; D005260:Female; D006966:Hyperprolactinemia / Q000097:blood / Q000139:chemically induced; D008090:Lisuride / Q000031:analogs & derivatives / Q000494:pharmacology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012110:Reserpine / Q000494:pharmacology; D012399:Rotation; D013239:Stereotyped Behavior / Q000187:drug effects; D013563:Sympathectomy, Chemical; D013565:Sympatholytics / Q000494:pharmacology
C117546:BAM 1120; D015259:Dopamine Agents; D018491:Dopamine Agonists; D004873:Ergolines; D013565:Sympatholytics; C006208:dironyl; D001971:Bromocriptine; D004958:Estradiol; D012110:Reserpine; D008090:Lisuride; D004298:Dopamine