title: Distribution of measles virus in the central nervous system of HIV-seropositive children.
abstract: In an autopsy study the distribution of measles virus (MV) in the central nervous system (CNS) of 18 measles-infected children (13 HIV seropositive, 5 HIV seronegative), in Abidjan, Ivory Coast was examined using immunocytochemistry and in situ hybridization. Of these children 17 died from measles giant cell pneumonia. In 3 of the 13 HIV-seropositive patients MV antigens and genomic RNA was detected in the CNS. One of these positive patients had an MV encephalitis with abundant virus throughout most of the CNS. MV was not detected in the CNS of any of the 5 HIV-seronegative patients. These findings, albeit in a small number of cases, would suggest there may be an increased susceptibility to infection of the CNS with MV in HIV-positive children. In this respect entry and growth of MV in the CNS in HIV-seropositive individuals may be similar to the occurrence of measles inclusion body encephalitis in immunocompromised individuals. Furthermore, comparison of the HIV-MV encephalitis patient with two patients with subacute sclerosing panencephalitis (SSPE) demonstrated a paucity of virus in neuronal processes in the HIV-MV encephalitis. Unlike in SSPE, MV maturation by budding through the plasma membrane may occur, thereby minimizing build up of and intracellular movement of incomplete virus.
authors.affiliation: Department of Neuropathology, Institute of Pathology, Royal Victoria Hospital, Belfast, Northern Ireland.
authors.forename: S
authors.initials: S
authors.lastname: McQuaid
authors.forename: S L
authors.initials: SL
authors.lastname: Cosby
authors.forename: K
authors.initials: K
authors.lastname: Koffi
authors.forename: M
authors.initials: M
authors.lastname: Honde
authors.forename: J
authors.initials: J
authors.lastname: Kirk
authors.forename: S B
authors.initials: SB
authors.lastname: Lucas
mesh_terms: D000328:Adult; D001921:Brain / Q000821:virology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D018023:HIV Seronegativity / Q000502:physiology; D006679:HIV Seropositivity / Q000821:virology*; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D007223:Infant; D008297:Male; D008457:Measles / Q000150:complications; D008459:Measles virus / Q000302:isolation & purification*; D013344:Subacute Sclerosing Panencephalitis / Q000821:virology