Three novel bicyclic 3,8-secotaxane diterpenoids from the needles of the chinese yew, taxus chinensis var. mairei
Three novel (1-3) and five known bicyclic 3,8-secotaxane diterpenoids were isolated from the needles of the Chinese yew, Taxus chinensis var. mairei. The structures of the new compounds were established, respectively, as (3E,7E)-2alpha,10beta, 13alpha-triacetoxy-5alpha,20-dihydroxy-3,8-secotaxa-3,7, 11-trien-9-one (1), (3E,7E)-2alpha,10beta-diacetoxy-5alpha,13alpha, 20-trihydroxy-3,8-secotaxa-3,7,11-trien-9-one (2), and (3E,8E)-7beta, 9,10beta,13alpha,20-pentaacetoxy-3,8-secotaxa-3,8,11-triene-2alpha, 5alpha-diol (2-deacetyltaxachitriene A) (3), on the basis of spectral analysis. The other five bicyclic taxane diterpenoids were determined as canadensene, 5-deacetyltaxachitriene B, taxachitriene B, taxuspine U, and taxuspine X by comparison of their physical properties and spectral data with those previously reported.
Shi
QW
Laboratory of Applied Bioorganic Chemistry, Division of Life Science, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amamiyamachi, Aoba-ku, Sendai 981-8555, Japan.
Oritani
T
Sugiyama
T
Kiyota
H