title: [Investigation on the viscoelastic properties of hepatocytes and their relavances to cytoskeleton structure].
abstract: Using micropipette aspiration technique, the authors investigated the viscoelastic properties of human fetal hepatocytes (HFH) and hepatocellular carcinoma (HCC) cells. And further, the effects of two cytoskeleton interferents, cytochalasin D and colchicine on the viscoelastic properties of HFHs were investigated. The results showed: the elastic coefficients K1 and K2 of HCC cells were significantly higher than those of HFHs; the action of cytochalasin D led to an obvious decrease in elastic coefficients K1, K2 as well as the viscous coefficient mu of HFHs; under the action of colchicine, the K1 value of HFHs increased while the K2 and mu values decreased obviously or tended to decrease. A brief discussion was presented about these results.
authors.affiliation: Bioengineering Research Institute, Chongqing University.
authors.forename: Z
authors.initials: Z
authors.lastname: Wu
authors.forename: G
authors.initials: G
authors.lastname: Zhang
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.forename: G
authors.initials: G
authors.lastname: Song
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.forename: M
authors.initials: M
authors.lastname: Long
authors.forename: S
authors.initials: S
authors.lastname: Cai
authors.forename: Y
authors.initials: Y
authors.lastname: Wu
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000503:physiopathology*; D002478:Cells, Cultured; D003078:Colchicine / Q000494:pharmacology*; D015638:Cytochalasin D / Q000494:pharmacology*; D003599:Cytoskeleton / Q000502:physiology; D004548:Elasticity / Q000187:drug effects; D005333:Fetus; D006801:Humans; D008099:Liver / Q000166:cytology / Q000502:physiology*; D008113:Liver Neoplasms / Q000473:pathology / Q000503:physiopathology*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014783:Viscosity / Q000187:drug effects
chemical_list: D015638:Cytochalasin D; D003078:Colchicine