title: [Severe hepatocellular damage after administration of paracetamol and chlorzoxazone in therapeutic dosage].
abstract: A 64 year old patient developed severe hepatocellular damage with jaundice and coagulopathy during ingestion of a combination of paracetamol and chlorzoxazone in therapeutic dosage. The risk factors for the development of liver cell necrosis following ingestion of paracetamol in therapeutic dosage are discussed. In particular in patients with risk factors (e.g. alcoholics and patients with heart failure) paracetamol-induced liver failure has to be considered in the presence of high transaminases, even when paracetamol was ingested in therapeutic dosage. Chlorzoxazone itself rarely can induce an idiosyncratic hepatocellular damage.
authors.affiliation: Medizinische Klinik, Regionalspital Langenthal.
authors.forename: A
authors.initials: A
authors.lastname: Kronenberg
authors.forename: S
authors.initials: S
authors.lastname: Krähenbühl
authors.forename: A
authors.initials: A
authors.lastname: Zimmermann
authors.forename: R
authors.initials: R
authors.lastname: Streuli
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000009:adverse effects*; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D002753:Chlorzoxazone / Q000008:administration & dosage / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D006801:Humans; D008099:Liver / Q000473:pathology; D017116:Low Back Pain / Q000188:drug therapy*; D008875:Middle Aged; D009125:Muscle Relaxants, Central / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D018712:Analgesics, Non-Narcotic; D009125:Muscle Relaxants, Central; D000082:Acetaminophen; D002753:Chlorzoxazone
vernacular_title: Schwerer hepatozellulärer Schaden nach Einnahme von Paracetamol und Chlorzoxazon in therapeutischer Dosierung.