[Protein and peptide construction for delivery of oligonucleotides and DNA into the cell].
The literary data on development and trial of new non-viral methods of antisense nucleotide, DNA and ribozyme delivery based on the application of protein and peptide constructions are summarised. For the creation of peptide constructions the proteins and functional fragments of proteins able to pass through a cellular membrane are used. The special attention is paid to the transport properties of recombinant fusion proteins containing translocation domain.
Pozmogova
G E
GE
Bioengineering Centre, Russian Academy of Sciences, Moscow.
Knoppe
D G
DG
D002462:Cell Membrane / Q000378:metabolism; D004247:DNA / Q000008:administration & dosage* / Q000493:pharmacokinetics; D016376:Oligonucleotides, Antisense / Q000008:administration & dosage* / Q000493:pharmacokinetics; D010455:Peptides / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*
D016376:Oligonucleotides, Antisense; D010455:Peptides; D011506:Proteins; D004247:DNA
Belkovye i peptidnye konstruktsii dlia dostavki v kletku oligonukleotidov i DNK.