Lentiviruses as gene transfer agents for delivery to non-dividing cells.
Lentiviral vectors are proving to be effective agents for the direct delivery and sustained expression of a transgene in several tissues, including brain, retina, muscle and liver. Significant progress was achieved in the biosafety of HIV-derived vectors by eliminating all the viral sequences non-essential for transduction. Other vectors have also been developed from non-primate lentiviruses.
Naldini
L
L
Cell Genesys, Foster City, CA, USA. luigin@cellgenesys.com
D000818:Animals; D001709:Biotechnology; D002455:Cell Division; D003673:Defective Viruses / Q000235:genetics; D018014:Gene Transfer Techniques; D005822:Genetic Vectors; D006678:HIV / Q000235:genetics; D006801:Humans; D016089:Immunodeficiency Virus, Feline / Q000235:genetics; D016086:Lentivirus / Q000235:genetics*; D012449:Safety; D014161:Transduction, Genetic