title: Biological effects of a neurotoxic pesticide at low concentrations on sea urchin early development. A terathogenic assay.
abstract: Dose-dependent terathogenic effects of an organophosphate insecticide were found during early sea urchin development. This biological assay is low cost, easy to measure, and allows to detect the effects of the exposure of organisms to the active principle at concentrations lower than the acceptable daily intake (ADI) for man. Effects were found independently from the stage of exposure, and were major as earlier exposure occurred. The stronger effects were exerted on the elongation of the skeletal rods, that was easily measured by following the migration of primary mesenchyme cells, labelled by WGA (wheat germ agglutinin).
authors.affiliation: Institute of Comparative Anatomy, University of Genova, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Morale
authors.forename: L
authors.initials: L
authors.lastname: Coniglio
authors.forename: C
authors.initials: C
authors.lastname: Angelini
authors.forename: G
authors.initials: G
authors.lastname: Cimoli
authors.forename: A
authors.initials: A
authors.lastname: Bolla
authors.forename: D
authors.initials: D
authors.lastname: Alleteo
authors.forename: P
authors.initials: P
authors.lastname: Russo
authors.forename: C
authors.initials: C
authors.lastname: Falugi
mesh_terms: D000818:Animals; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D008648:Mesoderm / Q000187:drug effects; D009943:Organophosphorus Compounds; D010063:Ovum / Q000187:drug effects; D012617:Sea Urchins / Q000187:drug effects* / Q000196:embryology; D013094:Spermatozoa / Q000187:drug effects; D018675:Toxicity Tests / Q000379:methods*; D014909:Wheat Germ Agglutinins
chemical_list: D007306:Insecticides; D009943:Organophosphorus Compounds; D014909:Wheat Germ Agglutinins