title: Metabolic rate in the right amygdala predicts negative affect in depressed patients.
abstract: The role of the amygdala in major depression was investigated. Resting regional cerebral metabolic rate (rCMRglu) was measured with [18F]fluorodeoxyglucose positron emission tomography (PET) in two samples of subjects using two different PET cameras. The samples consisted of 10 and 17 medication-free depressives and 11 and 13 controls, respectively. Using coregistration of PET and magnetic resonance images, regions were individually delineated for the amygdala and thalamus, the latter of which was used as a control region. Within the depressed groups, right amygdalar rCMRglu was positively correlated with negative affect. Thalamic rCMRglu was not related to negative affect, and amygdalar rCMRglu accounted for a significant portion of variance in depressives' negative affect scores over and above the contribution of thalamic rCMRglu.
authors.affiliation: Department of Psychology, University of Wisconsin, Madison 53706, USA.
authors.forename: H C
authors.initials: HC
authors.lastname: Abercrombie
authors.forename: S M
authors.initials: SM
authors.lastname: Schaefer
authors.forename: C L
authors.initials: CL
authors.lastname: Larson
authors.forename: T R
authors.initials: TR
authors.lastname: Oakes
authors.forename: K A
authors.initials: KA
authors.lastname: Lindgren
authors.forename: J E
authors.initials: JE
authors.lastname: Holden
authors.forename: S B
authors.initials: SB
authors.lastname: Perlman
authors.forename: P A
authors.initials: PA
authors.lastname: Turski
authors.forename: D D
authors.initials: DD
authors.lastname: Krahn
authors.forename: R M
authors.initials: RM
authors.lastname: Benca
authors.forename: R J
authors.initials: RJ
authors.lastname: Davidson
mesh_terms: D000679:Amygdala / Q000378:metabolism* / Q000503:physiopathology*; D003863:Depression / Q000000981:diagnostic imaging / Q000503:physiopathology*; D004644:Emotions / Q000502:physiology; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D013788:Thalamus / Q000378:metabolism; D014055:Tomography, Emission-Computed
chemical_list: D005947:Glucose