The use of locally delivered minocycline in the treatment of chronic periodontitis. A review of the literature.
Tetracyclines are frequently used in the treatment of periodontitis; however, emergence of resistant bacterial strains has decreased the utility of these drugs. At present, there are a lot of data in the literature from which one can draw conclusions regarding the use of local drug delivery. This paper reviews the utility and different systems of local delivery of minocycline, a semisynthetic tetracycline, in the treatment of periodontitis.
Vandekerckhove
B N
BN
Department of Periodontology, Catholic University of Leuven, Belgium.
Quirynen
M
M
van Steenberghe
D
D
D000287:Administration, Topical; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002908:Chronic Disease; D000075202:Contraindications; D006801:Humans; D008863:Microspheres; D008911:Minocycline / Q000008:administration & dosage* / Q000493:pharmacokinetics; D009824:Ointments; D010518:Periodontitis / Q000188:drug therapy* / Q000378:metabolism
D000900:Anti-Bacterial Agents; D009824:Ointments; D008911:Minocycline