title: Isolated leptomeningeal Castleman's disease with viral particles in the follicular dendritic cells.
abstract: To our knowledge, five cases of Castleman's disease involving only the central nervous system have been reported previously. We report a sixth case, which occurred in a 47-year-old woman with a 3-month history of headaches and a large superior frontal lobe mass on neuroimaging. Excisional biopsy revealed confluent lymphoid nodular areas with multiple well-developed germinal centers surrounded by concentrically layered proliferations of small B lymphocytes typical of Castleman's disease. Ultrastructural study found 100-nm virallike particles within follicular dendritic cells as well as intercellular spaces. These particles were suggestive of a D-type retrovirus. The patient underwent postoperative radiotherapy and was neurologically normal 3 months after surgery.
authors.affiliation: Department of Pathology, University of California at Los Angeles-Harbor Medical Center, Torrance, USA.
authors.forename: P
authors.initials: P
authors.lastname: Gulati
authors.forename: N C
authors.initials: NC
authors.lastname: Sun
authors.forename: B K
authors.initials: BK
authors.lastname: Herman
authors.forename: J W
authors.initials: JW
authors.lastname: Said
authors.forename: M E
authors.initials: ME
authors.lastname: Cornford
mesh_terms: D030121:Betaretrovirus / Q000648:ultrastructure*; D001927:Brain Diseases / Q000473:pathology / Q000821:virology*; D005871:Castleman Disease / Q000473:pathology / Q000821:virology*; D003713:Dendritic Cells / Q000648:ultrastructure / Q000821:virology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008578:Meninges / Q000648:ultrastructure / Q000821:virology*; D008875:Middle Aged; D012192:Retroviridae Infections / Q000473:pathology* / Q000821:virology; D014412:Tumor Virus Infections / Q000473:pathology* / Q000821:virology