Immunotherapy and mast cell activation.
Tryptase is the more specific markers for mast cell activation and mediators release and can be used as an index of mast cell activation after challenge. Nasal provocation tests have been done in patients allergic to the pollen of Parietaria (pellitory wall) before and after specific systemic immunotherapy and tryptase release evaluated in nasal lavage fluid. After specific immunotherapy the concentration of tryptase in nasal lavage was significantly decreased to all the concentrations used in challenge and the peack of tryptase release was delayed. These results confirm that assays of tryptase in nasal fluid after nasal provocation are a reliable markers of mast cell activation. Immunotherapy with specific allergen decreases mast cell reactivity to the same allergen.
Carlos
A G
AG
Clinica Universitaria de Medicina I, Instituto de Imunologia e Centro de Hematologia e Imunologia, Faculdade de Medicina de Lisboa, Portugal.
Carlos
M L
ML
Santos
M A
MA
Pedro
E
E
Santos
S
S
Lopes-Pregal
A
A
D000485:Allergens / Q000276:immunology; D053818:Chymases; D003888:Desensitization, Immunologic; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology* / Q000628:therapy; D008407:Mast Cells / Q000201:enzymology / Q000276:immunology*; D017817:Nasal Lavage Fluid / Q000737:chemistry*; D009299:Nasal Provocation Tests; D010940:Plant Proteins / Q000276:immunology; D011058:Pollen / Q000276:immunology; D012697:Serine Endopeptidases / Q000032:analysis*; D012882:Skin Tests; D053802:Tryptases
D000485:Allergens; C083860:Par j I protein, Parietaria judaica; D010940:Plant Proteins; D012697:Serine Endopeptidases; C083294:chymase 2; D053818:Chymases; D053802:Tryptases