[Methylation is a frequent mechanism of inactivation of the hMLH1 gene copies in sporadic colonic cancer].
Larsen
C J
CJ
D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D003110:Colonic Neoplasms / Q000235:genetics*; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics; D019175:DNA Methylation; D004260:DNA Repair; D006801:Humans; D018895:Microsatellite Repeats / Q000235:genetics; D000070957:MutL Protein Homolog 1; D009363:Neoplasm Proteins / Q000235:genetics* / Q000378:metabolism; D009687:Nuclear Proteins
D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; C501486:MLH1 protein, human; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D000070957:MutL Protein Homolog 1
La méthylation est un mécanisme fréquent d'inactivation des deux copies du gène hMLH1 dans les cancers coliques sporadiques.