Effects of risperidone on conditioned avoidance responding in male mice.
The effects of risperidone (0.1, 0.5 and 1 mg/kg) on active avoidance behaviour of BALB/C mice were explored in three acquisition sessions and in one subsequent performance session. In the acquisition phase, risperidone-treated animals showed a decrease in avoidances and in crossings in the adaptation period and in the intertrial intervals (ITIs), and an increase in non-responses; intermediate and high doses also decreased defecation. In the performance phase, 0.5 and 1 mg/kg risperidone decreased avoidance responses, crossings in the adaptation period and ITI crossing, which also decreased with 0.1 mg/kg. Moreover, 0.5 mg/kg of risperidone increased escape responses and 1 mg/kg increased non-responses and decreased defecation. The results show that risperidone has similar effects to other neuroleptics in the avoidance paradigm.
Aguilar
M A
MA
Facultad de Psicología, Universitat de Valencia, Spain.
Rodriguez-Arias
M
M
Marí-Sanmillán
M I
MI
Miñarro
J
J
D000818:Animals; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects*; D003672:Defecation / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011597:Psychomotor Performance / Q000187:drug effects; D018967:Risperidone / Q000008:administration & dosage / Q000494:pharmacology*
D014150:Antipsychotic Agents; D018967:Risperidone