title: Primary cervical malignant teratoma with a rib metastasis in an adult: five-year survival after surgery and chemotherapy. A case report with a review of the literature.
abstract: We report a case of a man presenting with a cervical malignant teratoma and a chondrosarcomatous rib metastasis. He was alive and free of recurrence five years and 10 months (= 70 months) after resection of the primary mass, followed by chemotherapy and subsequent resection of the rib tumor. This is the 35th patient reported in the literature and the first description in which an 'adjuvant' or primary chemotherapy was used. Previous patients with a cervical malignant teratoma, reported after lethal outcome, had survivals of one to 22 months (median nine months). In all patients with a preoperative clinical impression of an aggressive, differentiated or undifferentiated malignancy, the definite diagnosis of teratoma could only be made histologically. By analogy to germ cell tumors, the prognosis of malignant teratoma might be improved if complete excision is combined with new, adjuvant chemotherapy protocols for germ cell tumors. Lessons learned from this case are placed in the context of germ cell tumors in general and of non-gonadal malignant teratomas in particular.
authors.affiliation: Department of Nuclear Medicine, Inselspital, University of Berne, Switzerland. als@patho.unibe.ch
authors.forename: C
authors.initials: C
authors.lastname: Als
authors.forename: H
authors.initials: H
authors.lastname: Laeng
authors.forename: T
authors.initials: T
authors.lastname: Cerny
authors.forename: J A
authors.initials: JA
authors.lastname: Kinser
authors.forename: H
authors.initials: H
authors.lastname: Rösler
authors.forename: R
authors.initials: R
authors.lastname: Häusler
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D002574:Cervical Vertebrae / Q000473:pathology*; D017024:Chemotherapy, Adjuvant; D018572:Disease-Free Survival; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D011379:Prognosis; D012272:Ribs; D013125:Spinal Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D013724:Teratoma / Q000188:drug therapy / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D016896:Treatment Outcome