title: Failure of sorivudine therapy in progressive outer retinal necrosis caused by varicella zoster virus.
abstract: BACKGROUND
  We report on the case of a 23-year-old female who presented with ocular signs of progressive outer retinal necrosis (PORN) syndrome and who failed to respond to acyclovir, ganciclovir, foscarnet and oral sorivudine.
  
  
  METHODS
  The patient was treated with the antiviral drugs acyclovir, ganciclovir, foscarnet and oral sorivudine.
  
  
  RESULTS
  The patient failed to respond to a combination of antiviral drugs. Unfortunately, progression of the retintis occurred, which led to blindness.
  
  
  CONCLUSIONS
  Despite new drugs, the prognosis of PORN is poor and recurrence is common.
authors.affiliation: Department of Vitreoretinal Surgery, University of Cologne, Germany. gidir@ramat-negev.org.il
authors.forename: G
authors.initials: G
authors.lastname: Rosenthal
authors.forename: K U
authors.initials: KU
authors.lastname: Bartz-Schmidt
authors.forename: P
authors.initials: P
authors.lastname: Walter
authors.forename: B
authors.initials: B
authors.lastname: Kirchhof
authors.forename: K
authors.initials: K
authors.lastname: Heimann
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy* / Q000503:physiopathology / Q000821:virology; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D000998:Antiviral Agents / Q000627:therapeutic use*; D001086:Arabinofuranosyluracil / Q000031:analogs & derivatives* / Q000627:therapeutic use; D001766:Blindness / Q000821:virology; D004279:DNA, Viral / Q000032:analysis; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006563:Herpes Zoster Ophthalmicus / Q000188:drug therapy* / Q000503:physiopathology / Q000821:virology; D014645:Herpesvirus 3, Human / Q000235:genetics / Q000276:immunology; D006801:Humans; D012008:Recurrence; D015882:Retinal Necrosis Syndrome, Acute / Q000188:drug therapy* / Q000503:physiopathology / Q000821:virology; D017211:Treatment Failure
chemical_list: D000914:Antibodies, Viral; D000998:Antiviral Agents; D004279:DNA, Viral; D001086:Arabinofuranosyluracil; C031368:sorivudine