Fibrinogen plasma levels in an apparently healthy general population--relation to environmental and genetic determinants.
Elevated fibrinogen levels are an independent risk factor for cardiovascular ischemic disease. We investigated the relationship between cardiovascular ischemic risk factors, the fibrinogen Bbeta-chain G/A(-455) polymorphism and plasma fibrinogen levels in 989 apparently healthy subjects. Fibrinogen values were higher in subjects with C reactive protein (C-RP) >0.33 mg/dl, BMI >23.9 kg/m2, total cholesterol >4.84 mmol/l, triglycerides > 1.02 mmol/l, PAI-1 antigen >12.2 ng/ml, carriers of the A allele, first-degree relative history of coronary artery disease, or consuming >10 cigarettes per day (p<0.01). Men and ethanol drinkers showed lower plasma fibrinogen levels (p<0.01). The multivariate analysis confirmed the independent effect of C-RP, age, BMI, total cholesterol, gender, PAI-1, -455 G/A polymorphism, (p<0.05). BMI, total cholesterol, PAI-1, alcohol and smoking habit raised with the increase of age and differed between sexes. The A(-455) allele increasing effect was significant in women, especially in subjects aged <30 years, and in men aged <43 years. These results indicate that environmental factors contributed to a larger extent to fibrinogen variability, whereas the A(-455) allele was associated with a steeper increase in younger age quartiles.
Margaglione
M
M
Unitá di Trombosi e Aterosclerosi, I.R.C.C.S. Casa Sollievo della Sofferenza, S. Giovanni Rotondo, Italy.
Cappucci
G
G
Colaizzo
D
D
Pirro
L
L
Vecchione
G
G
Grandone
E
E
Di Minno
G
G
D000328:Adult; D000367:Age Factors; D000368:Aged; D000428:Alcohol Drinking / Q000097:blood / Q000453:epidemiology; D000483:Alleles; D015992:Body Mass Index; D005260:Female; D005340:Fibrinogen / Q000032:analysis* / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D007558:Italy; D008019:Life Style; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000453:epidemiology / Q000235:genetics; D017395:Plasminogen Activator Inhibitor 1 / Q000032:analysis; D011110:Polymorphism, Genetic; D012016:Reference Values; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology
D008055:Lipids; D017395:Plasminogen Activator Inhibitor 1; D005340:Fibrinogen