Reversible parkinsonism induced by prolonged treatment with valproate.
We describe two patients who developed levodopa-responsive parkinsonism without dementia at least 4 years after beginning chronic valproate (VPA) treatment for seizures. Parkinsonism disappeared in less than 3 months after VPA substitution with carbamazepine.
Onofrj
M
M
Dipartimento di Oncologia e Neuroscienze, Clinica Neurologica, Chieti, Italy. onofrj@ibmpe.unich.it
Thomas
A
A
Paci
C
C
D000368:Aged; D000927:Anticonvulsants / Q000009:adverse effects*; D000978:Antiparkinson Agents / Q000627:therapeutic use; D002230:Carbidopa / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010302:Parkinson Disease, Secondary / Q000139:chemically induced* / Q000188:drug therapy; D012074:Remission Induction; D012640:Seizures / Q000517:prevention & control; D014635:Valproic Acid / Q000009:adverse effects*
D000927:Anticonvulsants; D000978:Antiparkinson Agents; D007980:Levodopa; D014635:Valproic Acid; D002230:Carbidopa