title: Prolonged survival of stage IV malignant mixed Müllerian tumor of the ovary after carboplatin, mesna, ifosfamide, and cis-platin chemotherapy: case report.
abstract: Malignant mixed müllerian tumors (MMMT) of the ovary are rare, aggressive and rapidly progressive tumors. According to the available literature, the presence of metastatic disease rarely permits long term survival. We report on a 64-year old patient with stage IV ovarian MMMT who achieved a surgically-documented complete response (CR) after 6 cycles of carboplatin, mesna, ifosfamide, cis-platin. Pelvic recurrence was diagnosed 14 months later; the patient received 6 cycles of the same regimen used as first-line chemotherapy which resulted in a second complete response lasting for 4 months. The patient died 37 months after initial diagnosis due to intestinal occlusion. In the current case Ca 125 was significantly increased at clinical presentation of disease but not at the time of recurrence.
authors.affiliation: Department of Obstetrics and Gynecology, University of Bari, Policlinico, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Di Vagno
authors.forename: G
authors.initials: G
authors.lastname: Cormio
authors.forename: G
authors.initials: G
authors.lastname: Loverro
authors.forename: G A
authors.initials: GA
authors.lastname: Melilli
authors.forename: G
authors.initials: G
authors.lastname: Di Gesù
authors.forename: L
authors.initials: L
authors.lastname: Selvaggi
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D015080:Mesna / Q000008:administration & dosage; D051379:Mice; D008875:Middle Aged; D018200:Mixed Tumor, Mullerian / Q000188:drug therapy* / Q000601:surgery; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000601:surgery
chemical_list: D016190:Carboplatin; D015080:Mesna; D002945:Cisplatin; D007069:Ifosfamide