Genetic polymorphism and their contribution to cancer susceptibility.
Since the majority of chemical carcinogens are not capable of causing hazardous effects per se, the metabolism of these compounds is a crucial part of the initial host response to the environmental exposure. Disturbances in the balance between activation and detoxification may thus explain the individual variations in responses to exposures to carcinogens. The amount of the ultimate carcinogen produced depends on the action of competing activation and detoxification pathways involving cytochrome P450 and glutathione-S-transferases enzymes.
Conforti-Froes
N
N
Instituto de Biociências, Letras e Ciências Exatas, Universidade Estadual Paulista. Cristóvão Colombo 2265, São José do Rio Preto, São Paulo, SP 15054-000, Brasil.
el-Zein
R
R
Au
W
W
D003577:Cytochrome P-450 Enzyme System / Q000235:genetics / Q000378:metabolism; D004781:Environmental Exposure / Q000009:adverse effects; D004789:Enzyme Activation / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000201:enzymology / Q000235:genetics*; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000201:enzymology / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*
D003577:Cytochrome P-450 Enzyme System; D005982:Glutathione Transferase