Ischaemia-reperfusion injury. Implications for the hand surgeon.
Prolonged ischaemia sometimes occurs in replantation and free flap surgery. The re-establishment of circulatory flow to the ischaemic tissue leads to a cascade of events which augments tissue necrosis. This paper reviews the pathophysiology of this ischaemia-reperfusion injury and discusses different methods to modulate this injury.
al-Qattan
M M
MM
Division of Plastic Surgery, King Saud University, Riyadh, Saudi Arabia.
D002448:Cell Adhesion; D006225:Hand / Q000098:blood supply / Q000601:surgery*; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology; D007511:Ischemia / Q000209:etiology; D007962:Leukocytes / Q000473:pathology; D009336:Necrosis; D017382:Reactive Oxygen Species; D012039:Regional Blood Flow / Q000502:physiology; D015427:Reperfusion Injury / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control; D012092:Replantation / Q000009:adverse effects; D013524:Surgical Flaps / Q000009:adverse effects; D014661:Vasoconstriction
D018836:Inflammation Mediators; D017382:Reactive Oxygen Species