Solitary intraosseous infantile myofibroma of the orbital roof.
BACKGROUND
There are several rare tumors that can cause proptosis in an infant, including infantile myofibroma.


METHODS
A 3-month-old infant developed a painless, bone-destructive superomedial orbital mass, raising concern for orbital malignant neoplasms. Computed tomography disclosed a bone-destructive mass of the sphenoid wing. On magnetic resonance imaging, the intraosseous mass was well-circumscribed, surrounded by cortical bone, and showed prominent enhancement.


RESULTS
Superomedial orbitotomy and biopsy revealed a lesion composed of spindled to stellate cells, without mitotic activity, set in a fibromyxoid stroma. Immunohistochemical stains were positive for vimentin and actin. Ultrastructurally, there were actinlike thin filaments, mitochondria, and rough endoplasmic reticulum confirming a myofibroblastic proliferation and supporting the diagnosis of congenital infantile myofibroma.


CONCLUSIONS
Infantile myofibroma is a benign tumor that occurs rarely in the ocular region but can cause prominent bone destruction, misleading the clinician to suspect a malignant neoplasm.
Shields
C L
CL
Oncology Service, Wills Eye Hospital, Thomas Jeferson University, Philadelphia, Pa., USA.
Husson
M
M
Shields
J A
JA
Mercado
G
G
Eagle
R C
RC
D005260:Female; D006801:Humans; D007223:Infant; D007889:Leiomyoma / Q000151:congenital / Q000000981:diagnostic imaging / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D009918:Orbital Neoplasms / Q000151:congenital / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed