title: [Dynamic changes in the reactivity of the hormonal system regulation with the impact by LBNP sessions in long-term space mission].
abstract: Experiment INTERSTITIUM was performed on days 3, 170, 287, and 430 of the long-term MIR mission of the Russian cosmonaut-physician in order to evaluate reactivity of the system of hormonal regulation of homeostasis during LBNP sessions. Data of the experiment displayed different types of reaction of the volume controls to LBNP at the onset (F-3), in the course of and soon after recovery (R-4) from the extended mission which are signs of specific phases of adaptive shifts in the organism of cosmonaut. Exaggerated reactivity of the hormonal systems during LBNP in flight suggests more significant consequences of the test for the cardiovascular system of human in microgravity. The most expressed hormonal reaction to LBNP was documented at the very beginning of the postflight period. Plasma cGMP was materially reduced in the process of the mission and remained quite low on R-4; return of nucleotides to the norm was observed no earlier than on R-90. Complete recovery from the space mission took three months when the hormonal reaction to LBNP was same as prior to launch.
authors.forename: A I
authors.initials: AI
authors.lastname: Grigor'ev
authors.forename: V B
authors.initials: VB
authors.lastname: Noskov
authors.forename: V V
authors.initials: VV
authors.lastname: Poliakov
authors.forename: D V
authors.initials: DV
authors.lastname: Vorob'ev
authors.forename: I A
authors.initials: IA
authors.lastname: Nichiporuk
authors.forename: G
authors.initials: G
authors.lastname: Hinghofer-Szalkay
authors.forename: A
authors.initials: A
authors.lastname: Rossler
authors.forename: R
authors.initials: R
authors.lastname: Kvetnianski
authors.forename: L
authors.initials: L
authors.lastname: Macho
mesh_terms: D006728:Hormones / Q000097:blood*; D006801:Humans; D007866:Leg / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D013026:Space Flight; D013997:Time Factors
chemical_list: D006728:Hormones
vernacular_title: Dinamika reaktivnosti sistemy gormonal'noĭ reguliatsii pri vozdeĭstvii ODNT vo vremia dlitel'nogo kosmicheskogo poleta.