Inhibitory effect of cycloartenol ferulate, a component of rice bran, on tumor promotion in two-stage carcinogenesis in mouse skin.
Inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice was observed in the methanol extract of rice bran and gamma-oryzanol. The active components of rice bran, sitosterol ferulate, 24-methylcholesterol ferulate, cycloartenol ferulate and 24-methylenecycloartanol ferulate inhibited markedly the TPA-induced inflammation in mice. The 50% inhibitory dose of these compounds for TPA-induced inflammation was 0.2-0.3 mg/ear. Furthermore, cycloartenol ferulate markedly inhibited the tumor-promoting effect of TPA in 7,12-dimethylbenz[a]anthracene-initiated mice.
Yasukawa
K
K
College of Pharmacy, Nihon University, Chiba, Japan.
Akihisa
T
T
Kimura
Y
Y
Tamura
T
T
Takido
M
M
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D002273:Carcinogens; D003043:Cocarcinogenesis; D003877:Dermatitis, Contact / Q000209:etiology / Q000517:prevention & control; D005260:Female; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D051379:Mice; D008813:Mice, Inbred ICR; D012275:Oryza / Q000737:chemistry*; D010666:Phenylpropionates / Q000627:therapeutic use; D010840:Phytosterols / Q000627:therapeutic use*; D010936:Plant Extracts / Q000627:therapeutic use*; D012867:Skin / Q000187:drug effects; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000517:prevention & control*; D013261:Sterols / Q000627:therapeutic use; D013755:Tetradecanoylphorbol Acetate; D014315:Triterpenes
D016588:Anticarcinogenic Agents; D002273:Carcinogens; D000960:Hypolipidemic Agents; D010666:Phenylpropionates; D010840:Phytosterols; D010936:Plant Extracts; D013261:Sterols; D014315:Triterpenes; D015127:9,10-Dimethyl-1,2-benzanthracene; D013755:Tetradecanoylphorbol Acetate; C013172:gamma-oryzanol; C100089:cycloartenol