Histologic findings in polyacrylamide-coated polytetrafluoroethylene (PTFE) arterial grafts in the rat abdominal aorta.
To improve cell attachment without inducing thrombogenesis, the authors coated the inner surface of polytetrafluoroethylene (PTFE) prostheses (I.D.: 1 mm; length: 10 mm; wall thickness: 0.5 mm; fibril length: 30 microm) with polyacrylamide (PAA), known to have a strong antithrombotic effect (PAA-PTFE). They implanted the prostheses into the abdominal aorta of rats, and retrieved them at intervals of up to 9 months. Graft healing was observed under light and scanning electron microscopy. All the inner surfaces of the grafts examined were barely covered with fibrin or platelets. The PAA-coated fibers had many projections, in contrast to the original PTFE prostheses. Neo-endothelium was observed to be directly attached to these structural fibers of the PAA-PTFE grafts. Restoration of the neointima was also observed in these vascular prostheses.
Maeda
M
M
Department of Orthopedic Surgery, Nara Medical University, Kashihara City, Japan.
Fukui
A
A
Nakamura
T
T
Inada
Y
Y
Tamai
S
S
Haga
S
S
Tatsumi
K
K
Yamamoto
H
H
Ogata
S
S
Iwata
H
H
Ikada
Y
Y
D000180:Acrylic Resins; D000818:Animals; D001012:Aorta, Abdominal / Q000601:surgery / Q000648:ultrastructure*; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation; D020099:Coated Materials, Biocompatible; D008297:Male; D008855:Microscopy, Electron, Scanning; D011138:Polytetrafluoroethylene; D051381:Rats; D011916:Rats, Inbred F344; D013997:Time Factors; D000099166:Polyacrylamides
D000180:Acrylic Resins; D020099:Coated Materials, Biocompatible; D011138:Polytetrafluoroethylene; D000099166:Polyacrylamides