title: [Localized or metastatic cancer of the prostate: review of new treatment modalities].
abstract: Amongst men, prostatic adenocarcinoma is the most common cancer and the second most frequent cause of deaths. Widespread PSA measurement have led to earlier diagnosis. Recent clinical trials have tried to show an improvement in the prognosis. Early stages are mainly treated surgically even if local control results are similar with radiotherapy. Radiotherapy is the main stay of treatment for more locally advanced disease, either conventionally or conformational. Adjuvant hormonotherapy has been shown to improve survived as opposed to neoadjuvant hormonotherapy which only has local effects. The treatment of metastatic disease is palliative with the use of antiandrogens. In case of relapse, a second line of hormonotherapy or a chemotherapy is given. However the problem is the lack of effective drugs. Response rates to the main drug treatment are around 10 to 20%. New therapeutic approaches are now based on antimicrotubules agents but it is difficult to evaluate their efficacity. Further clinical trials will provide more information about improvement in survival rates and in quality of life.
authors.affiliation: Département d'oncologie-radiothérapie, Institut Curie, Paris.
authors.forename: E
authors.initials: E
authors.lastname: Deniaud-Alexandre
authors.forename: N
authors.initials: N
authors.lastname: Mounier
authors.forename: D
authors.initials: D
authors.lastname: Pontvert
authors.forename: J M
authors.initials: JM
authors.lastname: Cosset
mesh_terms: D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000628:therapy*
vernacular_title: Le cancer de la prostate localisé ou métastatique: revue des nouvelles modalités de prise en charge.