A mesenteric liposarcoma with production of granulocyte colony-stimulating factor.
A 77-year-old female was admitted to our hospital because of pyrexia and a right retroperitoneal mass. Leukocytosis and other inflammatory findings were noted. Bone-marrow aspiration revealed hypercellularity with no malignant cells. An additional mass was detected sonographically in the pelvis. The serum concentration of granulocyte colony-stimulating factor (G-CSF) was highly elevated (299 pg/ml). The tumors were removed at laparotomy, and the pelvic mass was found to arise from the ileocecal mesentery. Postoperatively, white blood cell count and serum G-CSF concentrations decreased to normal levels. The mesenteric tumor showed weakly positive immunostaining for human G-CSF, and Northern and polymerase chain reaction (PCR) analyses detected CSF and its mRNA in the mesenteric tumor.
Nakamura
A
A
Second Department of Internal Medicine, Showa University School of Medicine, Tokyo.
Tanaka
S
S
Takayama
H
H
Sakamoto
M
M
Ishii
H
H
Kusano
M
M
Onizuka
Y
Y
Ota
S
S
Mitamura
K
K
D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D007564:Japan / Q000453:epidemiology; D007964:Leukocytosis / Q000209:etiology*; D008080:Liposarcoma / Q000453:epidemiology / Q000378:metabolism*; D008643:Mesentery; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D009378:Neoplasms, Multiple Primary / Q000378:metabolism*; D010257:Paraneoplastic Syndromes / Q000209:etiology*; D010534:Peritoneal Neoplasms / Q000453:epidemiology / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis; D012334:RNA, Neoplasm / Q000096:biosynthesis; D012186:Retroperitoneal Neoplasms / Q000378:metabolism
D009363:Neoplasm Proteins; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D016179:Granulocyte Colony-Stimulating Factor