title: [Pleural malignant mesothelioma with osseous cartilaginous and rhabdomyogenic differentiation].
abstract: A 63-year-old man, who was formerly an asbestos factory worker who had been followed due to asbestosis, and was admitted to our hospital with left chest pain and dyspnea on exertion. A chest X-ray and chest computed tomogram (CT) on admission revealed a large tumor in the left lung field. Percutaneous needle biopsy determined that the tumor was a sarcoma. No clinical response was obtained by systemic chemotherapy. The autopsy revealed diffuse malignant mesothelioma of sarcomatous type with osseous, cartilaginous and rhabdomyogenic differentiation. Osseous and cartilaginous differentiation in a malignant mesothelioma is rare, and the presence of a malignant rhabdomyogenic component is the first to be described in the Japanese literature.
authors.affiliation: Department of Respiratory Disease, National Toneyama Hospital.
authors.forename: T
authors.initials: T
authors.lastname: Okamoto
authors.forename: S
authors.initials: S
authors.lastname: Yokota
authors.forename: K
authors.initials: K
authors.lastname: Shinkawa
authors.forename: H
authors.initials: H
authors.lastname: Kimura
authors.forename: K
authors.initials: K
authors.lastname: Nishino
authors.forename: M
authors.initials: M
authors.lastname: Ito
authors.forename: T
authors.initials: T
authors.lastname: Ogura
authors.forename: M
authors.initials: M
authors.lastname: Hanada
mesh_terms: D001195:Asbestosis / Q000150:complications; D001842:Bone and Bones / Q000473:pathology*; D002356:Cartilage / Q000473:pathology*; D002454:Cell Differentiation; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000473:pathology*; D008875:Middle Aged; D009132:Muscles / Q000473:pathology*; D010997:Pleural Neoplasms / Q000473:pathology*