title: Renal and hepatic interactions of acetaminophen and amikacin in the infant rat.
abstract: Results suggest that amikacin at the highest dose induces more changes on the renal function while the effect of APAP is more marked on the hepatic function. It might suggest that simultaneous administration of amikacin-APAP produces less changes that when the drugs are administered alone.
authors.affiliation: Department of Pharmacy, Escuela Nacional de Ciencias Biológicas, México, D.F., México.p6
authors.forename: M E
authors.initials: ME
authors.lastname: Meléndez Camargo
authors.forename: M
authors.initials: M
authors.lastname: Lozano Cortés
mesh_terms: D000082:Acetaminophen / Q000494:pharmacology*; D000410:Alanine Transaminase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000583:Amikacin / Q000494:pharmacology*; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001663:Bilirubin / Q000378:metabolism; D003404:Creatinine / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D005947:Glucose / Q000378:metabolism; D007668:Kidney / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D011188:Potassium / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000378:metabolism; D010130:p-Aminohippuric Acid / Q000378:metabolism
chemical_list: D018712:Analgesics, Non-Narcotic; D000900:Anti-Bacterial Agents; D011506:Proteins; D000082:Acetaminophen; D000583:Amikacin; D012964:Sodium; D003404:Creatinine; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D005947:Glucose; D001663:Bilirubin; D011188:Potassium; D010130:p-Aminohippuric Acid