title: [Effect of L-lysine-a-oxidase on reproduction of herpes simplex type I virus in vitro].
abstract: L-lysin-a-oxidase (LO), a fungal enzyme catalysing oxidative deamination of L-lysin, was used for the inhibition of the reproduction of herpes simplex virus type 1 (HSV-1). Antiviral activity of LO was tested in vitro. The expression of viral antigens and CPE of HSV-1 was inhibited by LO at a concentration 0.7 mg/ml.
authors.affiliation: Department of Biochemistry, Russian Peoples Friendship University.
authors.forename: I P
authors.initials: IP
authors.lastname: Smirnova
authors.forename: S V
authors.initials: SV
authors.lastname: Diorditsa
authors.forename: S B
authors.initials: SB
authors.lastname: Alekseev
authors.forename: I Z
authors.initials: IZ
authors.lastname: Zaĭtsev
mesh_terms: D000594:Amino Acid Oxidoreductases / Q000494:pharmacology*; D000818:Animals; D000956:Antigens, Viral / Q000187:drug effects; D000998:Antiviral Agents / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D018259:Herpesvirus 1, Human / Q000187:drug effects* / Q000276:immunology / Q000502:physiology; D014709:Vero Cells; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000956:Antigens, Viral; D000998:Antiviral Agents; D000594:Amino Acid Oxidoreductases; C041123:L-lysine oxidase
vernacular_title: Vliianie L-lisin-a-oksidazy na reproduktsiiu virusa gerpesa prostogo pervogo tipa in vitro.