title: Treatment of respiratory failure with inhaled nitric oxide and high- frequency ventilation in an infant with respiratory syncytial virus pneumonia and bronchopulmonary dysplasia.
abstract: In a 7-month-old infant with bronchopulmonary dysplasia and respiratory syncytial virus (RSV) pneumonia, we have shown an additive effect of high-frequency ventilation (HFV) and inhaled nitric oxide (iNO) in terms of improved oxygenation and the avoidance of extracorporeal membrane oxygenation. Apparently, the combined therapy of HFV and iNO is superior to either therapeutic modality alone in the treatment of hypoxemic respiratory failure due to RSV pneumonia. The mechanism of increased lung expansion and alveolar recruitment appears to be responsible for a favorable clinical outcome. We conclude that the combined therapy of HFV and iNO should be considered in hypoxemic respiratory failure in pediatric patients.
authors.affiliation: Pediatric Intensive Care Unit, University Children's Hospital, Freiburg, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Hoehn
authors.forename: M
authors.initials: M
authors.lastname: Krause
authors.forename: M
authors.initials: M
authors.lastname: Krueger
authors.forename: R
authors.initials: R
authors.lastname: Hentschel
mesh_terms: D000280:Administration, Inhalation; D001997:Bronchopulmonary Dysplasia / Q000150:complications*; D006612:High-Frequency Ventilation; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009569:Nitric Oxide / Q000008:administration & dosage*; D011024:Pneumonia, Viral / Q000150:complications*; D012131:Respiratory Insufficiency / Q000209:etiology / Q000628:therapy*; D018357:Respiratory Syncytial Virus Infections / Q000150:complications*; D016896:Treatment Outcome
chemical_list: D009569:Nitric Oxide