title: Cost-effectiveness of felodipine-metoprolol (Logimax) and enalapril in the treatment of hypertension.
abstract: We present results from a Swedish retrospective cost-effectiveness analysis of felodipine-metoprolol (Logimax) and enalapril in hypertension. In the 8-week trial, the average reduction of diastolic blood pressure (DBP) and the share of patients reaching target DBP were both significantly greater in the felodipine-metoprolol group. Cost of treatment (costs of drugs and physician visits) was somewhat higher in the felodipine-metoprolol group. After 8 weeks, an extra 4.8 mmHg reduction and an additional 22% of patients reaching target DBP were achieved with felodipine-metoprolol at the extra cost of SEK 19 (Swedish kronor, $US I=SEK 7.90). The incremental cost per mmHg reduction and per patient reaching target DBP was calculated at SEK 4 and SEK 86, respectively. Average cost-effectiveness ratios showed that the costs per mmHg reduction and per patient reaching target DBP after 8 weeks were 40 and 34% lower in the felodipine-metoprolol group, respectively. In conclusion, felodipine-metoprolol is cost-effective in the treatment of hypertension.
authors.affiliation: Health Economics & Quality of Life, Astra Draco AB, Lund, Sweden.
authors.forename: F
authors.initials: F
authors.lastname: Andersson
authors.forename: B
authors.initials: B
authors.lastname: Kartman
authors.forename: O K
authors.initials: OK
authors.lastname: Andersson
mesh_terms: D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000191:economics / Q000627:therapeutic use*; D003362:Cost-Benefit Analysis; D004338:Drug Combinations; D004656:Enalapril / Q000191:economics / Q000627:therapeutic use*; D015736:Felodipine / Q000191:economics / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000191:economics; D008297:Male; D008790:Metoprolol / Q000191:economics / Q000627:therapeutic use*; D008875:Middle Aged; D012189:Retrospective Studies; D013548:Sweden
chemical_list: D000959:Antihypertensive Agents; D004338:Drug Combinations; D004656:Enalapril; D008790:Metoprolol; D015736:Felodipine