Common variable immunodeficiency following Epstein-Barr virus infection.
The authors present a case of a patient who developed recurrent bacterial upper respiratory and pulmonary infections and marked hypogammaglobulinemia with a gradual decrease of serum IgG, IgA and IgM some months after acute Epstein-Barr virus infection. Test for identification of lymphocyte subpopulation showed increased CD8+ T-cells with a surface phenotype (CD8+, CD57+, HLA-DR+) characteristic of virus-induced, activated cytotoxic cells. Viral investigations showed a positive anti-EBNA titer, an IgG titer anti-VCA of 1:40, a negative IgG titer anti-EA and human immunodeficiency virus negativity. The authors conclude that these clinical features are indicative of possible common variable immunodeficiency following Epstein-Barr virus infection.
Zuccaro
G
G
Institute of Internal Medicine, Infectious Diseases and Immunopathology, University of Milan, Italy.
Della Bella
S
S
Polizzi
B
B
Vanoli
M
M
Scorza
R
R
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000328:Adult; D000361:Agammaglobulinemia / Q000209:etiology; D000914:Antibodies, Viral / Q000097:blood; D001424:Bacterial Infections / Q000209:etiology; D002927:Cimetidine / Q000627:therapeutic use; D017074:Common Variable Immunodeficiency / Q000188:drug therapy / Q000209:etiology*; D019309:Epstein-Barr Virus Nuclear Antigens / Q000276:immunology; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007244:Infectious Mononucleosis / Q000150:complications* / Q000276:immunology; D018655:Lymphocyte Count; D016131:Lymphocyte Subsets; D008297:Male; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000209:etiology; D019287:Zinc Sulfate / Q000627:therapeutic use
D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D019309:Epstein-Barr Virus Nuclear Antigens; D019287:Zinc Sulfate; D002927:Cimetidine