title: Human parvovirus B19-associated thrombocytopenic purpura.
abstract: We report two patients who presented with thrombocytopenic purpura (TP) associated with primary human parvovirus B19 (B19) infection. One patient also had transient liver dysfunction. In both cases, B19-DNA was detected in serum and bone marrow by polymerase chain reaction. Six months after the illness in patient 1 and 8 months after the illness in patient 2, B19-DNA disappeared from the serum. Serum immunoglobulin (Ig)G antibody to B19 remained positive in both cases, but B19 IgM antibody became negative 3 months after the onset in case 1 and 4 months after the onset in case 2. The mechanism of TP by B19 infection is unknown.
authors.affiliation: Department of Paediatrics, Showa Hospital, Aichi, Japan. wsy-4649@ari.bekkoame.or.jp
authors.forename: S
authors.initials: S
authors.lastname: Kido
authors.forename: Y
authors.initials: Y
authors.lastname: Ito
authors.forename: N
authors.initials: N
authors.lastname: Nishimura
authors.forename: Y
authors.initials: Y
authors.lastname: Kajita
authors.forename: T
authors.initials: T
authors.lastname: Ozaki
mesh_terms: D000293:Adolescent; D000914:Antibodies, Viral / Q000032:analysis; D002675:Child, Preschool; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D010322:Parvoviridae Infections / Q000150:complications*; D016732:Parvovirus B19, Human / Q000235:genetics / Q000276:immunology; D011696:Purpura, Thrombocytopenic / Q000209:etiology / Q000821:virology*
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral; D007074:Immunoglobulin G