Clinical and serologic follow-up in patients with neuroborreliosis.
The authors performed a clinical and serologic follow-up study after 4.2 +/- 1.2 years in 44 patients with clinical signs of neuroborreliosis and specific intrathecal antibody production. All patients had been treated with ceftriaxone 2 g/day for 10 days. Although neurologic deficits decreased significantly, more than half the patients had unspecific complaints resembling a chronic fatigue syndrome and showed persisting positive immunoglobulin M serum titers for Borrelia in the Western blot analysis.
Treib
J
J
Department of Neurology, University of the Saarland, Homburg, Germany.
Fernandez
A
A
Haass
A
A
Grauer
M T
MT
Holzer
G
G
Woessner
R
R
D000907:Antibodies, Bacterial / Q000097:blood; D000917:Antibody Formation; D015748:Borrelia burgdorferi Group / Q000276:immunology*; D002443:Ceftriaxone / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use; D004797:Enzyme-Linked Immunosorbent Assay; D005500:Follow-Up Studies; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008193:Lyme Disease / Q000097:blood / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology*; D009422:Nervous System Diseases / Q000097:blood / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology*; D012189:Retrospective Studies; D013997:Time Factors
D000907:Antibodies, Bacterial; D002511:Cephalosporins; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D002443:Ceftriaxone