title: Sensorineural hearing loss caused by NSAID-induced aseptic meningitis.
abstract: Aseptic meningitis is a rare complication of nonsteroidal anti-inflammatory drug (NSAID) use. Otologic symptoms may include sensorineural hearing loss and tinnitus. A 66-year-old woman sought the care of an otologist for sudden bilateral sensorineural hearing loss and a substantial increase in baseline tinnitus. The patient had previously undergone a left tympanoplasty secondary to cholesteatoma and had been treated for atypical face pain with ibuprofen taken every six hours for three months. Magnetic resonance imaging (MRI) with gadolinium demonstrated abnormal enhancement of the dura mater and the surrounding basal cisterns, with extension of enhancing dura mater into the internal auditory canals. Cerebrospinal fluid examination revealed evidence of aseptic meningitis. An audiogram confirmed new bilateral sensorineural hearing loss. Hearing loss and tinnitus resolved and no abnormalities were observed with MRI when nonsteroidal anti-inflammatory medication was discontinued. Otolaryngologists are well aware of the otologic sequelae in patients with meningitis. However, NSAIDs need to be considered as possible causal agents in the evaluation of meningitis with otologic symptoms.
authors.affiliation: Department of Otorhinolaryngology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA.
authors.forename: S P
authors.initials: SP
authors.lastname: Davison
authors.forename: M S
authors.initials: MS
authors.lastname: Marion
mesh_terms: D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001301:Audiometry, Pure-Tone / Q000379:methods; D001921:Brain / Q000473:pathology; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008582:Meningitis, Aseptic / Q000139:chemically induced* / Q000150:complications* / Q000473:pathology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal