Mechanisms and pathways from recent deoxysugar biosynthesis research.
In the past few years, there have been many important advances in our understanding of the biosynthesis of deoxysugars. Mechanistic studies have shed light on how enzymes can cleave C-O bonds, epimerize the configuration of substituents and reduce keto groups to make deoxysugars. Exciting progress has also been made in our comprehension of the genetics of deoxysugar biosynthesis in antibiotics. All this information is important for potential medical and biotechnological applications, such as drug discovery based on combinatorial biology.
Johnson
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Department of Chemistry, University of Minnesota, Minneapolis 55455, USA.
Liu
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D003855:Deoxyribose / Q000096:biosynthesis* / Q000235:genetics; D016695:Glycosyltransferases / Q000235:genetics / Q000378:metabolism*; D006601:Hexoses / Q000096:biosynthesis* / Q000235:genetics; D016930:Saccharopolyspora / Q000235:genetics / Q000378:metabolism; D013302:Streptomyces / Q000235:genetics / Q000378:metabolism
D006601:Hexoses; D003855:Deoxyribose; C009616:tyvelose; C022880:paratose; C023708:abequose; D016695:Glycosyltransferases