title: In vitro activity of the new ketolide HMR3647 in comparison with those of macrolides and pristinamycins against Enterococcus spp.
abstract: Ninety-four erythromycin-susceptible and 107 erythromycin-resistant enterococcal strains (MIC of >/=512 microgram/ml) were inhibited by the ketolide HMR3647 at MICs of </=0.007 to 0.06 and 0.03 to 8 microgram/ml, respectively. Eighteen vanA-positive isolates and 29 high-level-penicillin-resistant isolates, all of them erythromycin resistant, were inhibited by HMR3647 at an MIC range of 0.015 to 4 microgram/ml. The new ketolide has excellent activity against Enterococcus species.
authors.affiliation: Area de Bioquímica y Biología Molecular, Universidad de La Rioja, Logroño, Spain. carmen.torres@daa.unirioja.es
authors.forename: C
authors.initials: C
authors.lastname: Torres
authors.forename: M
authors.initials: M
authors.lastname: Zarazaga
authors.forename: C
authors.initials: C
authors.lastname: Tenorio
authors.forename: A
authors.initials: A
authors.lastname: Portillo
authors.forename: Y
authors.initials: Y
authors.lastname: Saenz
authors.forename: F
authors.initials: F
authors.lastname: Ruiz
authors.forename: F
authors.initials: F
authors.lastname: Baquero
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D016983:Enterococcus / Q000187:drug effects* / Q000235:genetics; D004917:Erythromycin / Q000494:pharmacology; D048628:Ketolides; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D010641:Phenotype; D014769:Virginiamycin / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D048628:Ketolides; D018942:Macrolides; D014769:Virginiamycin; D004917:Erythromycin; C106791:telithromycin