Striation is the characteristic neuritic abnormality in Alzheimer disease.
In this study, we found that neuropil threads of Alzheimer disease, rather than being continuous filaments along cell processes, show multiple interruptions. They are segmental in nature and therefore appear as striations rather than continuous filaments along the length of the neurite. Neuritic striation is not an artifact of section thickness since the majority of abnormal filament accumulations are extremely short. The dominance of short striations demonstrates that argyrophilic grains, rather than being distinct structures, simply represent a short variant of striation and that longer striations are arbitrarily considered neuropil threads. Ultrastructural examination showed that the intervals between striations lack a cytoskeleton. We suggest that neuritic striations may interrupt the microtubule system functionally blocking fast neuritic transport as well as playing a role in loss of neuronal connectivity.
Velasco
M E
ME
Division of Neuropathology, Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA.
Smith
M A
MA
Siedlak
S L
SL
Nunomura
A
A
Perry
G
G
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology*; D001370:Axonal Transport / Q000502:physiology; D006801:Humans; D008854:Microscopy, Electron; D008870:Microtubules / Q000378:metabolism; D008875:Middle Aged; D016501:Neurites / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D016874:Neurofibrillary Tangles / Q000473:pathology* / Q000648:ultrastructure; D009474:Neurons / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D019581:Neuropil / Q000473:pathology*; D013569:Synapses / Q000378:metabolism / Q000473:pathology