Kallikreins, kinins and cardiovascular diseases: a short review.
Studies of kallikrein-kinin systems since the 1930's have now led to substantial insight into the importance of this vasoactive system in the regulation of cardiovascular and renal function. It now seems clear that before long, these insights will lead to new therapeutic attacks upon diseases of the cardiovascular system and kidneys. This survey of notable recent work also emphasizes the fact that few of these fascinating new findings would have been produced without the stimulus of the initial discoveries of Héctor R Croxatto.
Margolius
H S
HS
Department of Pharmacology, Medical University of South Carolina, Charleston 29425-2251, USA. margolhs@musc.edu
D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000378:metabolism; D016234:Kallikrein-Kinin System / Q000502:physiology*; D007610:Kallikreins / Q000502:physiology*; D007705:Kinins / Q000502:physiology*
D007705:Kinins; D007610:Kallikreins