[Morphological changes in the central nervous system of animals depending on the dosage and time elapsed after exposure to low let radiation].
Analytical review of the morphological investigations of cerebral cortex neurons of various animals shortly after exposure to X- and gamma-radiation was made. Considered were data of qualitative and quantitative analyses of dystrophic changes in neurons of the sensorimotor cortex of the large cerebral hemispheres of rats immediately and a long period since X-irradiation. Results of the quantitative analysis of structural disorders in the central nervous system neurons suggest radiation-produced damages early after exposure of animals to relatively low doses. Higher incidence of irreversible changes in neurons of the experimental animals, as compared with intact controls, was stimulated by the doses of no more than 0.25 to 1.0 Gy. The relative number of structural disorders in neurons and percentage of irreversibly impaired cells rose proportionally to the dose growth and further delay of the time of investigation. Possible mechanisms of delayed disorders that led to a massive building-up of the number of dystrophic neurons following 3 to 4 months post irradiation of rats are discussed.
Fedorenko
B S
BS
Shafirkin
A V
AV
Budennaia
N N
NN
D000818:Animals; D002540:Cerebral Cortex / Q000473:pathology* / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D019150:Neuroaxonal Dystrophies / Q000209:etiology / Q000473:pathology; D009474:Neurons / Q000473:pathology* / Q000528:radiation effects*; D011833:Radiation Injuries, Experimental / Q000150:complications; D051381:Rats; D013997:Time Factors
Morfologicheskie izmeneniia v tsentral'noĭ nervnoĭ sisteme zhivotnykh v zavisimosti ot dozy i dremeni posle vozdeĭstviĭ izlucheniĭ s razlichnymi znachemiiami LPE.