title: Genesis of a novel human sequence from the protamine PRM1 gene.
abstract: The members of the male haploid expressed protamine 1 (PRM1)-->protamine 2 (PRM2)-->transition protein 2 (TNP2) locus exist as a single, coordinately expressed genic domain. Previous analysis has revealed that the genes within the human PRM1-->PRM2-->TNP2 domain are inter-related, as they share significant sequence similarity at both the nucleotide and amino acid levels. Analysis described here supports the view that a fourth candidate coding region, gene4/Prm3, was derived from PRM1 during the genesis of the PRM1-->PRM2-->TNP2 domain. In some species, gene4 has diverged to a great extent, which can limit its expression.
authors.affiliation: Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Kramer
authors.forename: S A
authors.initials: SA
authors.lastname: Krawetz
mesh_terms: D000818:Animals; D001483:Base Sequence; D002868:Chromosomal Proteins, Non-Histone; D019143:Evolution, Molecular; D006238:Haploidy; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000737:chemistry / Q000235:genetics*; D011479:Protamines / Q000737:chemistry / Q000235:genetics*; D016415:Sequence Alignment; D012689:Sequence Homology, Nucleic Acid
chemical_list: D002868:Chromosomal Proteins, Non-Histone; D009687:Nuclear Proteins; C082073:PRM1 protein, human; D011479:Protamines; C068621:protamine 2; C053886:spermatid transition proteins