Inversion of chromosome 16 in accelerated phase of chronic myeloid leukaemia: report of a case and review of the literature.
A patient with a Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) developed a blast crisis (FAB subtype AML-M2) without a monocytic involvement. Karyotype showed the presence of inv(16)(p13;q22) in addition to Ph, in 16/20 marrow metaphases.
Colović
M
M
Institute of Hematology, University Clinical Center, Belgrade, Yugoslavia.
Janković
G
G
Bila
J
J
Djordjević
V
V
Wiernik
P H
PH
D001752:Blast Crisis; D007446:Chromosome Inversion; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics*; D004804:Eosinophils; D006801:Humans; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010677:Philadelphia Chromosome