Prenatal karyotyping of choroid plexus cysts.
OBJECTIVE
A retrospective, descriptive study of 50 cases with choroid plexus cysts diagnosed by ultrasonography.


METHODS
All case charts were studied and additional information was collected regarding children born outside Uppsala.


RESULTS
All 50 cases were offered a test for chromosome aberrations, 46 accepted and were tested by chorion villi sampling or amniocentesis. In ten cases additional malformations were found, including one trisomy 13 and one trisomy 18. No relationship was found between the diameter, bilaterality or the complexity of the cyst.


CONCLUSIONS
Fetus with choroid plexus cysts should be examined carefully by ultrasonography. Since the complication risk of invasive diagnostic procedures is very small these patients may be offered a test for chromosomal aberrations.
Bakos
O
O
Department of Women's and Children's Health, Section for Obstetrics and Gynaecology, University Hospital, SE-751 85 Uppsala, Sweden.
Moen
K S
KS
Hansson
S
S
D000293:Adolescent; D000328:Adult; D001927:Brain Diseases / Q000000981:diagnostic imaging / Q000235:genetics*; D002831:Choroid Plexus / Q000000981:diagnostic imaging; D002869:Chromosome Aberrations / Q000235:genetics; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics; D003560:Cysts / Q000000981:diagnostic imaging / Q000235:genetics*; D003937:Diagnosis, Differential; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging / Q000235:genetics*; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping / Q000379:methods; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D014314:Trisomy; D016216:Ultrasonography, Prenatal