title: Therapeutic innovation: the up-front window.
authors.forename: E
authors.initials: E
authors.lastname: Frei
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy; D002648:Child; D002986:Clinical Trials as Topic; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage / Q000493:pharmacokinetics; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D019772:Topotecan / Q000008:administration & dosage / Q000493:pharmacokinetics
chemical_list: D019772:Topotecan; D008727:Methotrexate