Blood-brain barrier and blood volume imaging of cerebral glioma using functional CT: a pictorial review.
Five cases of cerebral glioma are presented here that illustrate the benefit of functional CT imaging of blood-brain barrier permeability and cerebral blood volume. Functional CT uses Patlak analysis of a single location dynamic sequence to extract physiological information that is useful clinically i the assessment of cerebral gliomas. Functional CT offers distinct advantages over other functional modalities including clearer delineation of tumour, tumour grading, measurement of tumour activity and monitoring response to therapy.
Leggett
D A
DA
Centre for Functional Imaging, Wesley Hospital, Brisbane, Queensland, Australia.
Miles
K A
KA
Kelley
B B
BB
D000368:Aged; D001810:Blood Volume; D001812:Blood-Brain Barrier; D001932:Brain Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D005260:Female; D005910:Glioma / Q000098:blood supply* / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed / Q000379:methods*