The role of membrane structure in the activation of mitochondrial phospholipases. 1. Activation of mitochondrial phospholipases by lipid peroxidation products.
Induction of lipid peroxidation is shown to alter the structure of mitochondrial membrane and to activate endogenous phospholipases A2, C, D, and lysophospholipase A. Fe(2+)-, cumene hydroperoxide- and ultraviolet-induced lipid peroxidation results in the activation of mitochondrial phospholipases.
Timusheva
Y T
YT
Tashkent State University, Biological Faculty, Department of Biophysics, Republic of Uzbekistan.
Mareninova
O A
OA
Vagina
O N
ON
Zamaraeva
M V
MV
Salakhutdinov
B A
BA
Aripov
T F
TF
Tashmukhamedov
B A
BA
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D001555:Benzene Derivatives / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D004578:Electron Spin Resonance Spectroscopy; D004789:Enzyme Activation; D007425:Intracellular Membranes / Q000187:drug effects / Q000201:enzymology* / Q000528:radiation effects; D007527:Isoenzymes / Q000378:metabolism; D015227:Lipid Peroxidation; D008563:Membrane Lipids / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology* / Q000528:radiation effects; D016877:Oxidants / Q000494:pharmacology; D010740:Phospholipases / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D014466:Ultraviolet Rays
D001555:Benzene Derivatives; D007527:Isoenzymes; D008563:Membrane Lipids; D008565:Membrane Proteins; D016877:Oxidants; D010743:Phospholipids; D010740:Phospholipases; C007164:cumene hydroperoxide; D001205:Ascorbic Acid; D002118:Calcium