title: Hypercalcemia in malignant paraganglioma due to parathyroid hormone-related protein.
abstract: A 15-year-old boy had hypercalcemia in association with malignant retroperitoneal paraganglioma. He had suppressed circulating levels of intact parathyroid hormone, whereas parathyroid hormone-related protein (PTHrP) immunoreactivity was elevated in plasma. Both the serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels were normal. Preoperatively the patient required control of hypercalcemia with intravenous pamidronate therapy. His circulating calcium and PTHrP concentrations became normal after a successful surgical resection of the primary retroperitoneal tumor. To our knowledge, this is the first reported case of elevated PtHrP levels in a patient with paraganglioma which resolved postoperatively.
authors.affiliation: Division of Endocrinology and Metabolism, University of California, San Francisco, Calif., USA. keh_chuan_loh@notes.ttsh.gov.sg
authors.forename: K
authors.initials: K
authors.lastname: Loh
authors.forename: K K
authors.initials: KK
authors.lastname: Matthay
authors.forename: M
authors.initials: M
authors.lastname: Hoover
authors.forename: F A
authors.initials: FA
authors.lastname: Bracho
authors.forename: A B
authors.initials: AB
authors.lastname: Cortez
authors.forename: F A
authors.initials: FA
authors.lastname: Conte
authors.forename: C T
authors.initials: CT
authors.lastname: Albanese
authors.forename: T R
authors.initials: TR
authors.lastname: Miller
authors.forename: D C
authors.initials: DC
authors.lastname: Price
authors.forename: A J
authors.initials: AJ
authors.lastname: Flores
authors.forename: A
authors.initials: A
authors.lastname: Kaviani
authors.forename: D
authors.initials: D
authors.lastname: Shoback
mesh_terms: D000293:Adolescent; D004164:Diphosphonates / Q000627:therapeutic use; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology* / Q000628:therapy; D008297:Male; D000077268:Pamidronate; D010235:Paraganglioma / Q000097:blood / Q000150:complications* / Q000601:surgery; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins / Q000378:metabolism*; D012186:Retroperitoneal Neoplasms / Q000097:blood / Q000150:complications* / Q000601:surgery; D014057:Tomography, X-Ray Computed
chemical_list: D004164:Diphosphonates; C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins; D000077268:Pamidronate