Ipsapirone neuroendocrine challenge: relationship to aggression as measured in the human laboratory.
Thirty-one human subjects were administered a neuroendocrine challenge with the 5-HT1a agonist ipsapirone after completing six sessions of a laboratory measure of aggression, the Point Subtraction Aggression Paradigm (PSAP), in order to determine if a laboratory measure of aggression was related to serotonin function. Subjects who showed more aggressive responding on the PSAP (n = 11) had a significantly blunted temperature response to ipsapirone compared to those with less aggressive responding (n = 20). There was no difference between the two groups on the cortisol response to ipsapirone. This study supports a relationship between serotonin function and aggression as measured in the human laboratory, similar to the well-documented association between self-reported aggression and serotonin.
Moeller
F G
FG
Department of Psychiatry and Behavioral Sciences, University of Texas Houston Health Science Center, 77030, USA. moeller@msi13.msi.uth.tmc.edu
Allen
T
T
Cherek
D R
DR
Dougherty
D M
DM
Lane
S
S
Swann
A C
AC
D000328:Adult; D000374:Aggression / Q000187:drug effects*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D008297:Male; D011388:Prolactin / Q000378:metabolism*; D011743:Pyrimidines / Q000494:pharmacology*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*
D011743:Pyrimidines; D017366:Serotonin Receptor Agonists; C043077:ipsapirone; D011388:Prolactin; D006854:Hydrocortisone