title: The Impact of Biology on Risk Assessment--workshop of the National Research Council's Board on Radiation Effects Research. July 21-22, 1997, National Academy of Sciences, Washington, DC.
abstract: The linear no-threshold extrapolation from a dose-response relationship for ionizing radiation derived at higher doses to doses for which regulatory standards are proposed is being challenged by some scientists and defended by others. It appears that the risks associated with exposures to doses of interest are below the risks that can be measured with epidemiological studies. Therefore, many have looked to biology to provide information relevant to risk assessment. The workshop reported here, "The Impact of Biology on Risk Assessment", was planned to address the need for additional information by bringing together scientists who have been working in key fields of biology and others who have been contemplating the issues associated specifically with this question. The goals of the workshop were to summarize and review the status of the relevant biology, to determine how the reported biological data might influence risk assessment, and to identify subjects on which more data are needed.
authors.affiliation: Oak Ridge National Laboratory, Tennessee 37830, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Fry
authors.forename: A
authors.initials: A
authors.lastname: Grosovsky
authors.forename: P C
authors.initials: PC
authors.lastname: Hanawalt
authors.forename: R F
authors.initials: RF
authors.lastname: Jostes
authors.forename: J B
authors.initials: JB
authors.lastname: Little
authors.forename: W F
authors.initials: WF
authors.lastname: Morgan
authors.forename: N L
authors.initials: NL
authors.lastname: Oleinick
authors.forename: R L
authors.initials: RL
authors.lastname: Ullrich
mesh_terms: D000818:Animals; D002869:Chromosome Aberrations; D003582:Cytogenetics; D004247:DNA / Q000235:genetics / Q000528:radiation effects; D004249:DNA Damage; D006801:Humans; D008954:Models, Biological; D011836:Radiation Tolerance; D011853:Radiobiology; D018570:Risk Assessment; D012958:Societies, Scientific; D014481:United States
chemical_list: D004247:DNA