Renal tolerability of teicoplanin in a case of neonatal overdose.
The literature does not contain reports regarding teicoplanin overdose in newborns. In a neonate with a history of recent postasphyctic acute renal failure which recovered within 7 days of life, antibiotic therapy with teicoplanin was started for sepsis due to Staphylococcus hominis. However, for 5 days the dosage was excessive (20 mg/kg twice daily instead of an initial dose of 16 mg/kg and then doses of 8 mg/kg once daily). Once this error had been noted, therapy was immediately suspended. Clinically the newborn had improved and blood culture at the end of the therapy was negative. Biohumoral tests revealed constantly normal levels of serum creatinine, serum cystatin C and blood nitrogen. Urinary parameters of tubulotoxicity were also within normal values. Urinary epidermal growth factor was increased. Teicoplanin was well tolerated at the renal level in the newborn even in this case of excessive dosage.
Fanos
V
V
Department of Pediatrics - University of Verona, Italy.
Mussap
M
M
Khoory
B J
BJ
Vecchini
S
S
Plebani
M
M
Benini
D
D
D058186:Acute Kidney Injury / Q000097:blood / Q000378:metabolism / Q000652:urine; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000506:poisoning*; D062787:Drug Overdose; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D018805:Sepsis / Q000097:blood / Q000188:drug therapy / Q000652:urine; D013203:Staphylococcal Infections / Q000097:blood / Q000188:drug therapy / Q000652:urine; D017334:Teicoplanin / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000506:poisoning*
D000900:Anti-Bacterial Agents; D017334:Teicoplanin