Standardized technique of laparoscopic surgery in the rat.
The evolution of advanced laparoscopic techniques requires animal models for instrument development, evaluation of the physiopathological correlation and physician training. Selection of surgical models is primarily based on cost, availability, anatomic and physiologic considerations, and housing and anesthetic methods. The use of large animals is becoming increasingly difficult due to restrictive legislation, public concern, and economic factors. A standardized technique of laparoscopic surgery in the rat has been developed to perform procedures in all abdominal regions including fundoplication, splenectomy, nephrectomy, liver resection, herniorraphy, colotomy, colectomy, and retroperitoneal exploration. The equipment consists of a specially designed small animal operating table, a standard arthroscope and micro-instruments. The rat model gives the opportunity to investigate the physiopathological relations and immune functions of laparoscopic procedures, to develop micro-instruments under realistic conditions of a live organism, and it is an excellent training model especially for pediatric and microsurgery. Besides low costs and easy availability, the rat model requires less logistic and financial efforts.
Gutt
C N
CN
Department of General Surgery, Johann Wolfgang Goethe University, Frankfurt/Main, Germany.
Riemer
V
V
Brier
C
C
Berguer
R
R
Paolucci
V
V
D000818:Animals; D003082:Colectomy / Q000379:methods; D004195:Disease Models, Animal; D018662:Fundoplication / Q000379:methods; D006498:Hepatectomy / Q000379:methods; D006552:Hernia, Inguinal / Q000601:surgery; D010535:Laparoscopy / Q000379:methods*; D008297:Male; D011028:Pneumoperitoneum, Artificial; D051381:Rats; D017207:Rats, Sprague-Dawley; D013156:Splenectomy / Q000379:methods