title: Postnatal exposure to chlorinated dioxins and related chemicals on thyroid hormone status in Japanese breast-fed infants.
abstract: Effects of postnatal exposure to polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and coplanar polychlorinated biphenyls (Co-PCBs) on thyroid hormone status were studied in the peripheral blood of 36 breast-fed Japanese infants. Estimated total intakes of these chemicals in toxic equivalent quantity (TEQ) converted into 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) from the breast milk significantly and negatively correlated with the levels of triiodothyronine (T3) and thyroxine (T4) in the blood of breast-fed babies. Therefore, exposure to background levels of the highly toxic organochlorine chemicals through the breast milk may cause some effects on thyroid hormone status in Japanese infants.
authors.affiliation: Laboratory of Environmental Health Sciences, School of Health Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Nagayama
authors.forename: K
authors.initials: K
authors.lastname: Okamura
authors.forename: T
authors.initials: T
authors.lastname: Iida
authors.forename: H
authors.initials: H
authors.lastname: Hirakawa
authors.forename: T
authors.initials: T
authors.lastname: Matsueda
authors.forename: H
authors.initials: H
authors.lastname: Tsuji
authors.forename: M
authors.initials: M
authors.lastname: Hasegawa
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: H Y
authors.initials: HY
authors.lastname: Ma
authors.forename: T
authors.initials: T
authors.lastname: Yanagawa
authors.forename: H
authors.initials: H
authors.lastname: Igarashi
authors.forename: J
authors.initials: J
authors.lastname: Fukushige
authors.forename: T
authors.initials: T
authors.lastname: Watanabe
mesh_terms: D000328:Adult; D001572:Benzofurans / Q000009:adverse effects*; D001942:Breast Feeding; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008895:Milk, Human / Q000737:chemistry*; D011078:Polychlorinated Biphenyls / Q000009:adverse effects*; D000072317:Polychlorinated Dibenzodioxins / Q000009:adverse effects / Q000031:analogs & derivatives*; D013960:Thyroid Function Tests; D013963:Thyroid Hormones / Q000032:analysis* / Q000378:metabolism
chemical_list: D001572:Benzofurans; D000072317:Polychlorinated Dibenzodioxins; D013963:Thyroid Hormones; D011078:Polychlorinated Biphenyls