Amplification of int-2 and bcl-1 genes in squamous cell carcinoma of the larynx.
We studied int-2 and bcl-1 gene amplification in 21 operated patients with cancer of the larynx. In 9 cases, the int-2 gene was amplified (42.9%) and in 4 cases. the bcl-1 gene was amplified (25.0%). Co-amplification of int-2 and bcl-1 was observed in three cases (18.8%), all of which were glottic carcinomas. Other amplified cases were supraglottic carcinomas. Tumor specimens with int-2 amplification were associated with a significantly worse prognosis. We suggest that int-2 amplification is one of the prognostic factors in laryngectomized patients with cancer of the larynx.
Miyahara
H
H
Department of Otolaryngology, Head and Neck Surgery, Nara Medical University, Kashihara, Japan.
Naito
H
H
Ueda
K
K
Yane
K
K
Matsunaga
T
T
Okaichi
K
K
Ohnishi
T
T
D000328:Adult; D000368:Aged; D015139:Blotting, Southern / Q000379:methods; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D005784:Gene Amplification / Q000235:genetics*; D019940:Genes, bcl-1 / Q000235:genetics*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009693:Nucleic Acid Hybridization / Q000379:methods; D009857:Oncogenes / Q000235:genetics*; D011379:Prognosis
D004273:DNA, Neoplasm