Mechanisms of tubular sodium chloride transport.
Extracellular fluid volume is determined by sodium and its accompanying anions. There are control mechanisms which regulate sodium balance in the body. These include high and low pressure baroreceptors, intrarenal baroreceptors, renal autoregulation, tubuloglomerular feedback, aldosterone, and numerous other physical and hormonal factors. Sodium transport by the nephron involves active and passive processes which occur in several different nephron segments. Mechanisms of cotransport, Na(+)-H+ exchange, antiporters and ion-specific channels are all utilized by the nephron to maintain sodium balance. These regulatory factors and transport mechanisms for sodium in the kidney will he discussed in detail.
Venkatesh
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Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Denver, USA.
Schrier
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Andreoli
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D001693:Biological Transport, Active; D005110:Extracellular Space / Q000378:metabolism; D005919:Glomerular Filtration Rate; D006801:Humans; D007684:Kidney Tubules / Q000378:metabolism*; D009318:Natriuresis; D015222:Sodium Channels; D012965:Sodium Chloride / Q000378:metabolism*
D015222:Sodium Channels; D012965:Sodium Chloride