title: Investigations on the synthesis and properties of 4-aminosubstituted 2,6,7-trimethyl-1,5-dioxo-1,2,5,6-tetrahydropyrido[3,4-d]pyridazines.
abstract: Synthesis of 4-aminosubstituted 2,6,7-trimethyl-1,5-dioxo-1,2,5,6-tetrahydropyrido[3,4-d]pyridazin es 2-11 and the results of the preliminary pharmacological screening of the selected compounds 2, 4, 5, 10, 11 are described in this paper.
authors.affiliation: Department of Chemistry of Drugs, Wrocław University of Medicine, Poland.
authors.forename: H
authors.initials: H
authors.lastname: Sladowska
authors.forename: J
authors.initials: J
authors.lastname: Stanasiuk
authors.forename: M
authors.initials: M
authors.lastname: Sieklucka-Dziuba
authors.forename: T
authors.initials: T
authors.lastname: Saran
authors.forename: Z
authors.initials: Z
authors.lastname: Kleinrok
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D005260:Female; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D015394:Molecular Structure; D009043:Motor Activity / Q000187:drug effects; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
chemical_list: D000700:Analgesics; D000970:Antineoplastic Agents; D011724:Pyridazines