Genetic contribution of the tumor necrosis factor region in Guillain-Barré syndrome.
We studied genetic polymorphisms in the tumor necrosis factor (TNF) region in 81 Japanese patients with Guillain-Barré syndrome (GBS) and 85 controls. A significantly higher frequency of the 100-base pair (bp) (TNFa2) allele of the TNFa microsatellite marker, which is associated with high TNF alpha production, existed in Campylobacter jejuni-positive (Cj+) GBS patients than in controls, suggesting the involvement of a genetic predisposition to high TNF alpha secretion in the development of C. jejuni-related GBS.
Ma
J J
JJ
Department of Neurology and Clinical Research Center, Utano National Hospital, Kyoto, Japan.
Nishimura
M
M
Mine
H
H
Kuroki
S
S
Nukina
M
M
Ohta
M
M
Saji
H
H
Obayashi
H
H
Kawakami
H
H
Saida
T
T
Uchiyama
T
T
D000483:Alleles; D002169:Campylobacter Infections / Q000235:genetics / Q000276:immunology; D016123:Campylobacter jejuni; D017931:DNA Primers; D006801:Humans; D007564:Japan; D018895:Microsatellite Repeats; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011129:Polyradiculoneuropathy / Q000235:genetics*; D012016:Reference Values; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D017931:DNA Primers; D014409:Tumor Necrosis Factor-alpha