title: Factor V Leiden and prothrombin gene G 20210 A variant in children with ischemic stroke.
abstract: OBJECTIVE
  To investigate if the factor V Leiden mutation (F-V-LM) and/or the prothrombin gene G 20210 A variant (P-G20210A-V) are risk factors for acute stroke in Austrian children.
  
  
  METHODS
  33 children with acute ischemic stroke documented by computer tomography and/or magnetic resonance imaging of the brain were enrolled in an open multicenter survey.
  
  
  RESULTS
  6/33 children had F-V-LM (5 heterozygous, 1 homozygous). This represents 18% (95% CI: 6.7-39.9%) of our pediatric stroke population and thus exceeds the expected prevalence in the Austrian population of 4,6% (Fischer's exact test, p = 0.01). F-V-LM was not found in 11 children with neonatal stroke but in 6/22 children with stroke after the neonatal period. 5/6 children with F-V-LM had an underlying disorder that is a risk factor for stroke in children. The P-G20210A-V was detected in 1/26 (3.85%; 95% CI: 0.1-21.4%) patients. Comparison of the prevalence of P-G20210A-V in our study with that in the general population of Austria of 1% revealed no statistical significance (Fischer's exact test, p = 0.38).
  
  
  CONCLUSIONS
  Our data suggest that the F-V-LM is a risk factor for acute stroke in Austrian children beyond the neonatal period. The P-G20210A-V apparently does not represent a risk factor for stroke in Austrian children.
authors.affiliation: Department of Pediatrics, University of Graz, Austria. werner.zenz@kfunigraz.ac.at
authors.forename: W
authors.initials: W
authors.lastname: Zenz
authors.forename: Z
authors.initials: Z
authors.lastname: Bodó
authors.forename: J
authors.initials: J
authors.lastname: Plotho
authors.forename: W
authors.initials: W
authors.lastname: Streif
authors.forename: C
authors.initials: C
authors.lastname: Male
authors.forename: G
authors.initials: G
authors.lastname: Bernert
authors.forename: L
authors.initials: L
authors.lastname: Rauter
authors.forename: G
authors.initials: G
authors.lastname: Ebetsberger
authors.forename: K
authors.initials: K
authors.lastname: Kaltenbrunner
authors.forename: P
authors.initials: P
authors.lastname: Kurnik
authors.forename: A
authors.initials: A
authors.lastname: Lischka
authors.forename: F
authors.initials: F
authors.lastname: Paky
authors.forename: R
authors.initials: R
authors.lastname: Ploier
authors.forename: G
authors.initials: G
authors.lastname: Höfler
authors.forename: C
authors.initials: C
authors.lastname: Mannhalter
authors.forename: W
authors.initials: W
authors.lastname: Muntean
mesh_terms: D020016:Activated Protein C Resistance / Q000453:epidemiology / Q000235:genetics; D001317:Austria / Q000453:epidemiology; D002545:Brain Ischemia / Q000453:epidemiology / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005165:Factor V / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011516:Prothrombin / Q000235:genetics*; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics*; D012307:Risk Factors; D019851:Thrombophilia / Q000453:epidemiology / Q000235:genetics*
chemical_list: C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin