Thrombophilia and activated protein C resistance.
In addition to classic vascular insults such as inflammation, trauma, malignancy, and surgery, a number of hereditary coagulation defects predispose patients to a wide array of thrombotic complications. A novel genetic defect in factor V allowing for resistance to its cleavage by activated protein C has recently been implicated in a significant number of cases of familial thrombophilia. A brief case report and review of the literature is presented to familiarize surgeons to this important and quite frequent cause of hypercoagulability.
Selzman
C H
CH
Section of Vascular Surgery, University of Colorado Health Sciences Center, Denver, CO, USA.
Whitehill
T A
TA
Krupski
W C
WC
D020016:Activated Protein C Resistance / Q000150:complications* / Q000235:genetics; D000293:Adolescent; D006801:Humans; D008297:Male; D019851:Thrombophilia / Q000209:etiology*; D020246:Venous Thrombosis / Q000209:etiology*