title: Fluoroquinolone-resistant Moraxella catarrhalis in a patient with pneumonia: report from the SENTRY Antimicrobial Surveillance Program (1998).
abstract: Fluoroquinolone resistance in Moraxella catarrhalis isolates has been quite rare. This report presents a case history of a 22-year-old man with compromised immune status and severe pneumonia caused by M. catarrhalis. The organism was markedly resistant (MICs, 1.5- > 32 micrograms/mL) to several marketed fluoroquinolones including the agent (levofloxacin) used for concurrent and prior therapy. The emergence of this problematic strain seems related to chronic exposure of the patient to compounds in the class and poor patient compliance to prescribed medications. The strain was not clonally related to other M. catarrhalis strains isolated in the same hospital during early 1998. This second documented case of a fluoroquinolone-resistant M. catarrhalis clinical isolate presents a warning that resistances can emerge in at-risk patients, and that surveillance systems (SENTRY) will be necessary to monitor for unusual organisms and spread of resistance phenotypes among commonly isolated respiratory tract pathogens.
authors.affiliation: Summa Health Systems, Akron City Hospital, Ohio, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: DiPersio
authors.forename: R N
authors.initials: RN
authors.lastname: Jones
authors.forename: T
authors.initials: T
authors.lastname: Barrett
authors.forename: G V
authors.initials: GV
authors.lastname: Doern
authors.forename: M A
authors.initials: MA
authors.lastname: Pfaller
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D006801:Humans; D016867:Immunocompromised Host; D064704:Levofloxacin; D008297:Male; D008826:Microbial Sensitivity Tests; D001936:Moraxella catarrhalis / Q000187:drug effects* / Q000302:isolation & purification; D016870:Neisseriaceae Infections / Q000382:microbiology*; D015242:Ofloxacin / Q000494:pharmacology*; D018410:Pneumonia, Bacterial / Q000382:microbiology*; D011159:Population Surveillance
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D064704:Levofloxacin; D015242:Ofloxacin