Spectral and biological characteristics of some Acyclovir salts.
In the present work there are described some spectral characteristics in the ultraviolet and infrared region under various environment conditions for a series of synthetic analogues of deoxyguanosine, substances possessing antiviral properties. The study is performed on the Acyclovir compounds and on its Na, K and Li salts, synthetized in Romania, in comparison with the similar product Zovirax, of the "Wellcome" firm (England), used in the clinical practice for several years. The results show a very marked resemblance of the spectral behavior for all these products, a conclusion confirmed by the similar biological effects in the herpetic infection.
Zaharia
C N
CN
Stefan S. Nicolau Institute of Virology, Bucharest.
Crişan
I
I
Rojanschi
D
D
Muţiu
A
A
D000212:Acyclovir / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D005453:Fluorescence; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D006801:Humans; D013056:Spectrophotometry, Ultraviolet
D000998:Antiviral Agents; D000212:Acyclovir