title: The growth hormone secretagogue KP-102-induced stimulation of food intake is modified by fasting, restraint stress, and somatostatin in rats.
abstract: The effects of fasting, restraint stress, and intracerebroventricular (i.c.v.) injection of somatostatin on the growth hormone secretagogue, KP-102-induced stimulation of food intake were examined in rats. KP-102-induced stimulation of food intake was observed in freely-fed rats but not in 24-h starved rats. A 90 min period of restraint stress decreased food intake, and i.c.v. administration of KP-102 counteracted the suppressive effect of restraint on food intake. I.c.v. administration of somatostatin partially attenuated the KP-102-induced stimulation of food intake in freely-fed rats, while somatostatin itself did not change food intake. These results suggest that the stimulatory effect of KP-102 on feeding behavior is evident in freely-fed rats but not in starved rats, and that the effect of KP-102 is counteracted or attenuated by stress or somatostatin.
authors.affiliation: Department of Physiology, Nippon Medical School, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Shibasaki
authors.forename: N
authors.initials: N
authors.lastname: Yamauchi
authors.forename: K
authors.initials: K
authors.lastname: Takeuchi
authors.forename: S
authors.initials: S
authors.lastname: Ishii
authors.forename: H
authors.initials: H
authors.lastname: Sugihara
authors.forename: I
authors.initials: I
authors.lastname: Wakabayashi
mesh_terms: D000818:Animals; D005215:Fasting / Q000502:physiology*; D005247:Feeding Behavior / Q000187:drug effects*; D013006:Growth Hormone / Q000378:metabolism; D007276:Injections, Intraventricular; D008297:Male; D009842:Oligopeptides / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013004:Somatostatin / Q000494:pharmacology*; D013312:Stress, Physiological / Q000503:physiopathology*
chemical_list: D009842:Oligopeptides; D013004:Somatostatin; D013006:Growth Hormone; C091874:growth hormone-releasing peptide-2