HIV infection: how effective is drug combination treatment?
The rate of decline of plasma HIV RNA in patients treated with anti-retroviral drugs has been postulated to reflect the half-lives of previously HIV-infected cells. Here, Zvi Grossman and colleagues argue that the observed decline is explained by the kinetics of ongoing infection cycles. Residual cell-to-cell infection that becomes increasingly difficult to block could stabilize cellular provirus reservoirs.
Grossman
Z
Z
NIH Office of AIDS Research, Bethesda, MD 20892, USA. wepaul@nih.gov
Feinberg
M
M
Kuznetsov
V
V
Dimitrov
D
D
Paul
W
W
D019380:Anti-HIV Agents / Q000627:therapeutic use*; D015496:CD4-Positive T-Lymphocytes / Q000821:virology; D004359:Drug Therapy, Combination; D006678:HIV / Q000187:drug effects / Q000302:isolation & purification / Q000502:physiology; D015658:HIV Infections / Q000188:drug therapy* / Q000517:prevention & control / Q000821:virology; D006801:Humans; D008954:Models, Biological; D008962:Models, Theoretical; D012367:RNA, Viral / Q000097:blood; D019562:Viral Load; D014779:Virus Replication / Q000187:drug effects
D019380:Anti-HIV Agents; D012367:RNA, Viral