title: Simultaneous laboratory-based comparison of ResMed Autoset with polysomnography in the diagnosis of sleep apnoea/hypopnoea syndrome.
abstract: ResMed Autoset (AS) is a simplified diagnosis system for obstructive sleep apnoea/hypopnoea syndrome (OSAS) based on the respiratory flow/time relationship by pressure variation measured through simple nasal prongs. A multicentre prospective trial was used to compare AS and polysomnography (PSG) for diagnosing 95 patients, with suspected OSAS. Physicians gave a pretest probability of the patient having OSAS. The apnoea/hypopnoea index (AHI) was compared between the two methods of diagnosis for the whole population and for subgroups according to the pretest probability. Twenty-four patients had AHI < 15 events x h(-1) on PSG and 19 AHI 15-30, and 52 patients had AHI > or = 30. Correlation between AHI assessed by AS and PSG was r=0.87 for total sleep time (TST), p<0.0001. A Bland and Altman plot gave an agreement between the two methods of +/-40%. For a threshold of AHI > or = 15 events x h(-1) to diagnose OSAS, AS has a sensitivity of 92%, specificity of 79%, positive predictive value of 93% and negative predictive value of 76%. With a pretest probability > or = 80%, sensitivity and positive predictive value were 98 and 100% respectively. Of six false negative, four had a high pretest probability (> 80%) or Epworth score > or = 10. Using these parameters as a criterion for proceeding to PSG after a negative AS study would mean that two apnoeic patients (AHI 20 and 17 events x h(-1) by PSG) would escape detection. The Autoset is useful for the detection of obstructive sleep apnoea but with high pretest probability and a negative Autoset result polysomnography should be performed.
authors.affiliation: Groupe PPC, Commission Medico-Technique et Sociale, Association Nationale pour la Traitement à Domicile de l'Insuffisance Respiratoire, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Mayer
authors.forename: J C
authors.initials: JC
authors.lastname: Meurice
authors.forename: F
authors.initials: F
authors.lastname: Philip-Joet
authors.forename: A
authors.initials: A
authors.lastname: Cornette
authors.forename: D
authors.initials: D
authors.lastname: Rakotonanahary
authors.forename: N
authors.initials: N
authors.lastname: Meslier
authors.forename: J L
authors.initials: JL
authors.lastname: Pepin
authors.forename: P
authors.initials: P
authors.lastname: Lévy
authors.forename: D
authors.initials: D
authors.lastname: Veale
mesh_terms: D000328:Adult; D000368:Aged; D003936:Diagnosis, Computer-Assisted; D005260:Female; D006801:Humans; D007040:Hypoventilation / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D017286:Polysomnography / Q000379:methods*; D011237:Predictive Value of Tests; D011336:Probability; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D012891:Sleep Apnea Syndromes / Q000175:diagnosis*