title: Epidural anesthesia combined with propofol sedation for abdominal hysterectomy in a patient with amyotrophic lateral sclerosis--a case report.
abstract: Amyotrophic lateral sclerosis (ALS) is a disease characterized by progressive degeneration of the lower motor neurons, motor nuclei of the brain stem, and the descending pathway of the upper motor neurons. As the disease progresses, atrophy and weakness involve most of the skeletal muscles, including those of the tongue, pharynx larynx and chest. Impairment of respiration, altered response to muscle relaxants, and predisposition of aspiration affect a safe anesthetic management. General anesthesia with tracheal intubation might ensure intraoperative ventilatory management, but it could also increase the risk of aspiration with its entailing airway obstruction and demand the need of postoperative artificial ventilatory support. In this report, we described the use of epidural analgesia with 2% lidocaine combined with continuous infusion of low dose propofol for sedation for a ALS patient undergoing abdominal hysterectomy. The anesthetic management of this patient was smooth and successful. Besides, epidural morphine could provide excellent postoperative pain relief without respiratory complications.
authors.affiliation: Department of Anesthesiology, National Taiwan University Hospital, Taipei, R.O.C.
authors.forename: L K
authors.initials: LK
authors.lastname: Chen
authors.forename: Y
authors.initials: Y
authors.lastname: Chang
authors.forename: C C
authors.initials: CC
authors.lastname: Liu
authors.forename: W Y
authors.initials: WY
authors.lastname: Hou
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000150:complications*; D000767:Anesthesia, Epidural; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use*; D007044:Hysterectomy; D008875:Middle Aged; D015742:Propofol / Q000627:therapeutic use*
chemical_list: D006993:Hypnotics and Sedatives; D015742:Propofol