Inhaled nitric oxide prevents left ventricular impairment during endotoxemia.
We evaluated the effect of long-term inhalation of nitric oxide (NO) on cardiac contractility after endotoxemia by using the end-systolic elastance of the left ventricle (LV) as a load-independent contractility index. Chronic instrumentation in 12 pigs included implantation of two pairs of endocardial dimension transducers to measure LV volume and a micromanometer to measure LV pressure. One week later, the animals were divided into a control group (n = 6) or a NO group (n = 6). All animals received intravenous Escherichia coli endotoxin (10 micrograms. kg-1. h-1) and equivalent lactated Ringer solution. NO inhalation (20 parts/million) was begun 30 min after the initiation of endotoxemia and was continued for 24 h. In both groups, tachycardia, pulmonary hypertension, and systemic hyperdynamic changes were noted. The end-systolic elastance in the control group was significantly decreased beyond 7 h. NO inhalation maintained the end-systolic elastance at baseline levels and prevented its impairment. These findings indicate that NO exerts a protective effect on LV contractility in this model of endotoxemia.
Ishihara
S
S
US Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, USA.
Ward
J A
JA
Tasaki
O
O
Pruitt
B A
BA
Goodwin
C W
CW
Mozingo
D W
DW
Cioffi
W G
WG
D000280:Administration, Inhalation; D000818:Animals; D004195:Disease Models, Animal; D019446:Endotoxemia / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006976:Hypertension, Pulmonary / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D009200:Myocardial Contraction / Q000187:drug effects; D009569:Nitric Oxide / Q000008:administration & dosage*; D010100:Oxygen / Q000097:blood; D013552:Swine; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects; D018487:Ventricular Dysfunction, Left / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*
D009569:Nitric Oxide; D010100:Oxygen