Stereological estimates of nuclear volume in thin malignant melanomas.
Stereological estimation of nuclear volume was performed in a case control study of 72 malignant melanomas, thickness < or = 0.8 mm and Clark's level II-III. However, stereological measurements could be performed in only 57 thin melanomas due to too sparse cellularity. Thus, 21 thin metastasizing melanomas were individually compared with 33 thin non-metastasizing melanomas after individual matching of cases with one or two randomly chosen controls for site of primary tumour, tumour thickness, level of invasion, tumour regression and follow-up. Conditional logistic regression analysis showed no significant differences in nuclear volume between metastasizing and non-metastasizing thin malignant melanomas.
Björnhagen
V
V
Department of Plastic and Reconstructive Surgery, Karolinska Institute and Hospital, Stockholm, Sweden.
Månsson-Brahme
E
E
Lindholm
J
J
Mattsson
A
A
Sørensen
F B
FB
D002467:Cell Nucleus; D006801:Humans; D008545:Melanoma / Q000473:pathology* / Q000556:secondary / Q000648:ultrastructure; D009367:Neoplasm Staging