Apheresis platelets: emerging issues related to donor platelet count, apheresis platelet yield, and platelet transfusion dose.
Emerging issues in stimulating apheresis platelet donors with platelet growth factors, the relative costs of apheresis and random donor platelet concentrates, optimal platelet transfusion dose, and leucoreduction of platelet products have caused renewed debate regarding apheresis products vs. random, pooled concentrates. The future role of apheresis products in platelet transfusion therapy will in large part be determined by costs, which are increasingly recognized to be influenced by donor platelet count, apheresis yield, and platelet transfusion dose.
Goodnough
L T
LT
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA. goodnough@labmed.wustl.edu
Kuter
D
D
McCullough
J
J
Brecher
M E
ME
D001782:Blood Donors; D006801:Humans; D010976:Platelet Count; D010983:Plateletpheresis / Q000191:economics / Q000379:methods