The addition of GTN to capsaicin cream reduces the discomfort associated with application of capsaicin alone. A volunteer study.
In a double blind, placebo controlled trial of 40 volunteers, the burning discomfort associated with application of capsaicin cream (0.025%) was compared to placebo, GTN cream (1.33%) and to the combination of capsaicin cream (0.025%) plus GTN cream 1.33%. Median VAS for burning pain were 0 for the placebo, GTN and GTN + capsaicin groups and 3 for the capsaicin group after single application of each cream at daily intervals. This study demonstrates that after single application the addition of GTN to capsaicin significantly reduces the burning discomfort associated with application of capsaicin alone.
McCleane
J G
JG
Pain Clinic, Craigavon Area Hospital, 68 Lurgan Road, Portadown, BT63 5QQ UK.
McLaughlin
M
M
D002211:Capsaicin / Q000008:administration & dosage* / Q000009:adverse effects* / Q000494:pharmacology; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D006801:Humans; D005996:Nitroglycerin / Q000008:administration & dosage / Q000627:therapeutic use*; D009824:Ointments; D010146:Pain / Q000139:chemically induced* / Q000188:drug therapy*; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D014838:Volunteers
D009824:Ointments; D014665:Vasodilator Agents; D005996:Nitroglycerin; D002211:Capsaicin