Chronic rejection and chronic cyclosporin toxicity in renal allografts.
Recent evidence indicates that growth factors are critically important in both chronic rejection and chronic cyclosporin A toxicity, suggesting that these two entities share a common pathophysiological pathway, leading to progressive allograft failure. Here, Manuel Pascual and colleagues discuss the relevance of growth factors to chronic allograft nephropathy, and the implications for therapy in view of the great choice of immunosuppressive drugs now available.
Pascual
M
M
Renal Unit and Transplantation Unit, Massachusetts General Hospital, Boston, USA. mpascual@partners.org
Swinford
R D
RD
Ingelfinger
J R
JR
Williams
W W
WW
Cosimi
A B
AB
Tolkoff-Rubin
N
N
D000818:Animals; D015152:Blotting, Northern; D002460:Cell Line; D002908:Chronic Disease; D016572:Cyclosporine / Q000009:adverse effects*; D003609:Dactinomycin / Q000627:therapeutic use; D006084:Graft Rejection / Q000209:etiology* / Q000517:prevention & control / Q000628:therapy; D006133:Growth Substances / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation / Q000276:immunology*; D019384:Nucleic Acid Synthesis Inhibitors / Q000627:therapeutic use; D012333:RNA, Messenger; D051381:Rats; D016212:Transforming Growth Factor beta / Q000276:immunology
D006133:Growth Substances; D007166:Immunosuppressive Agents; D019384:Nucleic Acid Synthesis Inhibitors; D012333:RNA, Messenger; D016212:Transforming Growth Factor beta; D003609:Dactinomycin; D016572:Cyclosporine