title: [Drug-induced osteomalacia].
abstract: The osteomalacia is a metabolic bone disease, characterized by a defect of bone mineralization, due to a lot of causes; among these an important role may be attributed to some drugs. The drugs most frequently associated with osteomalacia are: cholestyramine, phenytoin, phenobarbital, rifampicin, isoniazid, aluminium-containing antacid, saccharated ferric oxide, cadmium, lead, bisphosphonates, fluoride and aluminum. In this review we discuss about the pathophysiologic mechanisms related to drug-induced osteomalacia involving vitamin D metabolism, phosphorus homeostasis and bone mineralization.
authors.affiliation: Cattedra di Medicina Interna, Policlinico Umberto I, Università La Sapienza, Roma.
authors.forename: E
authors.initials: E
authors.lastname: D'Erasmo
authors.forename: A
authors.initials: A
authors.lastname: Ragno
authors.forename: N
authors.initials: N
authors.lastname: Raejntroph
authors.forename: D
authors.initials: D
authors.lastname: Pisani
mesh_terms: D064420:Drug-Related Side Effects and Adverse Reactions; D006706:Homeostasis; D006801:Humans; D008903:Minerals / Q000378:metabolism; D010018:Osteomalacia / Q000139:chemically induced* / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism; D014807:Vitamin D / Q000378:metabolism
chemical_list: D008903:Minerals; D014807:Vitamin D; D010758:Phosphorus
vernacular_title: Osteomalacia da farmaci.