title: Management of recurrent pilocytic astrocytoma with leptomeningeal dissemination in childhood.
abstract: Two cases of recurrent pilocytic astrocytoma with leptomeningeal dissemination (LMD) are described. A 6-year-old boy presented with a cerebellar tumor, which was subtotally removed. Tumor recurrence with LMD occurred 4 years later. Reoperation for tumor removal followed by craniospinal irradiation stabilized the LMD over 5 years. A 4-year-old girl presented with a chiasmatic-hypothalamic tumor. Partial removal of the tumor was followed by radiation therapy. Tumor regrowth with LMD occurred 4 years later and was managed by reoperation, chemotherapy and radiotherapy. Tumor recurrence with LMD can be stabilized by multimodal treatment without tumor progression.
authors.affiliation: Department of Neurosurgery, Gunma University School of Medicine, Maebashi, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Tamura
authors.forename: A
authors.initials: A
authors.lastname: Zama
authors.forename: H
authors.initials: H
authors.lastname: Kurihara
authors.forename: H
authors.initials: H
authors.lastname: Fujimaki
authors.forename: H
authors.initials: H
authors.lastname: Imai
authors.forename: T
authors.initials: T
authors.lastname: Kano
authors.forename: F
authors.initials: F
authors.lastname: Saitoh
mesh_terms: D001099:Arachnoid / Q000473:pathology*; D001254:Astrocytoma / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D002528:Cerebellar Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007029:Hypothalamic Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D009897:Optic Chiasm; D010841:Pia Mater / Q000473:pathology*