Synaptic transmission: two players team up for a new tune.
An unexpected link has been found between two molecules that were thought to perform seemingly unrelated functions. The AMPA-subclass glutamate receptor GluR2 interacts with the membrane-fusion protein NSF in a manner that appears important for receptor-mediated intracellular signalling.
Jahn
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Department of Neurobiology Max-Planck-Institute for Biophysical Chemistry Am Fassberg D-37077 Göttingen, Germany. rjahn@gwdg.de.
D002352:Carrier Proteins / Q000502:physiology*; D052066:N-Ethylmaleimide-Sensitive Proteins; D018091:Receptors, AMPA / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*; D033921:Vesicular Transport Proteins
D002352:Carrier Proteins; D018091:Receptors, AMPA; D033921:Vesicular Transport Proteins; D052066:N-Ethylmaleimide-Sensitive Proteins; C104722:glutamate receptor ionotropic, AMPA 2