[Identification of HLA-DR alleles for susceptibility to rheumatoid polyarthritis in Senegal].
Rheumatoid arthritis is the most frequent inflammatory rheumatism disease. Several studies were aimed to understand its physiopathogenesis in particular the association between some HLA-DR alleles and rheumatoid arthritis. A prospective study was carried out in 34 patients suffering from RA (30 Women and 4 men). The diagnosis was clinically and radiologically made. The control group included 220 persons of which the HLA-DR distribution was known. The HLA-DRB1 alleles were typed by PCR-SSP (Sequence Specific Primers). The most frequent HLA-DR alleles found in patients group were: DR10 (85.3%), DR52 (53%), DR14 (38.2%), DR11 (26.5%), and DR13 (20.3%). A significant difference was observed between RA patients and control group for the following alleles: DR3, DR10, DR18, and DR52 (p < 0.001; Chi square with Yates' correction). HLA-DR3 and DR10 were positively associated with RA. The relative risk was up 30 for DR10.
Dieye
A
A
Immunologie Moléculaire, Institut Pasteur de Dakar, Sénégal.
Diallo
S
S
Diatta
M
M
Thiam
A
A
Ndiaye
R
R
Bao
O
O
Sarthou
J L
JL
D000328:Adult; D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D044383:Black People / Q000235:genetics; D017931:DNA Primers; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006684:HLA-DR Antigens / Q000032:analysis / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012306:Risk; D012675:Senegal
D017931:DNA Primers; D006684:HLA-DR Antigens
Identification des allèles HLA-DR de susceptibilité a la polyarthrite rhumatoïde au Sénégal.