Selective degeneration of sudomotor fibers in Ross syndrome and successful treatment of compensatory hyperhidrosis with botulinum toxin.
We report a 5-year follow-up of a patient with Ross syndrome. A biopsy of the anhidrotic skin immunostained with protein gene product 9.5 visualized by confocal microscopy revealed selective loss of sudomotor fibers, whereas epidermal innervation remained intact, providing the first morphologic evidence of selective loss of sudomotor fibers in this syndrome. Among the different treatment strategies employed for the patient's disabling segmental hyperhidrosis, intracutaneous injection of botulinum toxin A was the most helpful.
Bergmann
I
I
Neurologische Universitätsklinik, Würzburg, Germany.
Dauphin
M
M
Naumann
M
M
Flachenecker
P
P
Müllges
W
W
Koltzenburg
M
M
Sommer
C
C
D000222:Adaptation, Physiological / Q000502:physiology; D000328:Adult; D001341:Autonomic Nervous System / Q000503:physiopathology; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D002799:Cholinergic Fibers / Q000502:physiology*; D004594:Electrophysiology; D006801:Humans; D006945:Hyperhidrosis / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology*; D007271:Injections, Intradermal; D008297:Male; D009410:Nerve Degeneration / Q000503:physiopathology*; D009465:Neuromuscular Agents / Q000627:therapeutic use*; D011680:Pupil; D012021:Reflex, Abnormal / Q000502:physiology; D012867:Skin / Q000473:pathology; D013545:Sweat Glands / Q000294:innervation*; D013577:Syndrome
D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A