Evaluation of anti-HIV activity of 5-(2-phenyl-3'-indolal)-2-thiohydantoin.
The anti-HIV activity of the previously synthesized 5-(2-phenyl-3'-indolal)-2-thiohydantoin I was evaluated. The compound, containing two structural moieties found in highly active anti-HIV agents, exhibited poor activity and rather high cytotoxicity.
Suzen
S
S
Department of Pharmaceutical Chemistry, Faculty of Pharmacy (ECZACILIK), Ankara University, Turkey.
Buyukbingol
E
E
D019380:Anti-HIV Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D004341:Drug Evaluation; D015497:HIV-1 / Q000187:drug effects*; D007211:Indoles / Q000494:pharmacology*; D010669:Phenylthiohydantoin / Q000031:analogs & derivatives*; D013329:Structure-Activity Relationship
C116135:5-(2-phenyl-3'-indolal)-2-thiohydantion; D019380:Anti-HIV Agents; D007211:Indoles; D010669:Phenylthiohydantoin