Studies on the nature of cytotoxic effects induced by dihydralazine.
The effects of scavengers on the cytotoxicity of dihydralazine were evaluated. Pretreatment of two kinds of mammalian cells cultured in vitro with catalase or sodium dismutase abolished partially or almost totally the effects of the drug. Hydroxyl radicals scavengers dimethylsulphoxide and D-mannitol minimized the cytotoxic response of both kinds of cells.
Marczewska
J
J
Drug Institute, Warsaw, Poland.
Koziorowska
J H
JH
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004078:Dihydralazine / Q000633:toxicity*; D016166:Free Radical Scavengers / Q000494:pharmacology; D000882:Haplorhini
D016166:Free Radical Scavengers; D004078:Dihydralazine