title: Effect of triiodothyronine administration on the recovery of liver oxidative capacity after partial hepatectomy.
abstract: The aim of the present work was to investigate the role of triiodothyronine on liver regeneration after partial hepatectomy in the rat. During the first 3 days of liver regeneration, total protein, total DNA content and total cytochrome c oxidase activity of the residual tissue increased from 30% immediately after partial hepatectomy to 70% of the preoperative values in control rats. In triiodothyronine-treated rats, the increase in total protein was the same (70%), however, the increase in total liver DNA content and total cytochrome c oxidase acitivity was 100 and 135%, respectively during the first 3 days of regeneration. Triiodothyronine administration also increased significantly the activity of mitochondrial ATPase in regenerating liver.
authors.affiliation: Department of Physiology, Faculty of Medicine, Charles University, Hradec Králové, Prague, Czech Republic. wolff@lfhk.cuni.cz
authors.forename: Z
authors.initials: Z
authors.lastname: Cervinková
authors.forename: R
authors.initials: R
authors.lastname: Svátková
authors.forename: M
authors.initials: M
authors.lastname: Kalous
authors.forename: H
authors.initials: H
authors.lastname: Rauchová
authors.forename: M
authors.initials: M
authors.lastname: Cervinka
authors.forename: Z
authors.initials: Z
authors.lastname: Drahota
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D004247:DNA / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000378:metabolism; D006498:Hepatectomy; D007700:Kinetics; D008099:Liver / Q000187:drug effects* / Q000378:metabolism*; D008115:Liver Regeneration / Q000187:drug effects* / Q000502:physiology*; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology; D010084:Oxidation-Reduction; D011506:Proteins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014284:Triiodothyronine / Q000494:pharmacology*
chemical_list: D011506:Proteins; D014284:Triiodothyronine; D004247:DNA; D003576:Electron Transport Complex IV; D000251:Adenosine Triphosphatases