Diacylglycerol--when is it an intracellular messenger?
Distinct, structurally different forms of sn-1,2-diacylglycerol are found in cells, these are polyunsaturated, mono- or di-unsaturated and saturated. The pathways that generate or metabolise sn-1, 2-diacylglycerol are reviewed. The evidence that it is the polyunsaturated forms of sn-1,2-diacylglycerol, but the more saturated forms of phosphatidate which function as intracellular signals is considered.
Wakelam
M J
MJ
Institute for Cancer Studies, Birmingham University, Queen Elizabeth Hospital, Clinical Research Block, Birmingham B15 2TA, UK. m.j.o.wakelam@bham.ac.uk
D000818:Animals; D004075:Diglycerides / Q000096:biosynthesis / Q000737:chemistry / Q000502:physiology*; D010712:Phosphatidic Acids / Q000378:metabolism; D010739:Phospholipase D / Q000378:metabolism; D015398:Signal Transduction; D013329:Structure-Activity Relationship
D004075:Diglycerides; D010712:Phosphatidic Acids; D010739:Phospholipase D