Fas and Fas ligand-mediated apoptosis and its role in autoimmune diabetes.
The relationship between Fas-mediated apoptosis and Type 1 diabetes is currently under investigation. Fas/Fas ligand interaction could be involved both in the insulitis process and in beta-cell death. Nevertheless, different mechanisms appear to be involved in human Type 1 diabetes and in NOD mice. In the present work, we review recent evidence of the role of the Fas/Fas ligand system in human and NOD mouse diabetes, describing possible hypotheses for its involvement in the pathogenesis of the disease, with possible implications for therapy and islet transplantation.
Signore
A
A
Clinica Medica II, University La Sapienza, Rome, Italy. a.signore@caspur.it
Annovazzi
A
A
Gradini
R
R
Liddi
R
R
Ruberti
G
G
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D001327:Autoimmune Diseases; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology* / Q000601:surgery; D006801:Humans; D016381:Islets of Langerhans Transplantation; D051379:Mice; D016688:Mice, Inbred NOD; D019014:fas Receptor / Q000502:physiology*
D019014:fas Receptor