Microgrooved subcutaneous implants in the goat.
We investigated the behavior of microgrooved implants in soft tissue using polystyrene implantable disks, either smooth or microgrooved (1-10 microm) on both sides. The implants were placed subcutaneously in a goat for 1, 4, or 12 weeks. Light and transmission electron microscopy showed that fibrous capsule formation around the implants was fairly uniform. After 1 week the implants were covered with a fibrous capsule about 80 microm thick. The collagen matrix was loose, and many inflammatory cells were present. After 4 weeks the matrix was more dense and contained many newly formed blood vessels. At the implant surface a layer of inflammatory cells about 10 microm thick had accumulated. Finally, after 12 weeks the matrix had densified. One cellular layer of inflammatory cells was present at the implant surface. We carried out histomorphometric measurements of capsule thickness, inflammatory layer thickness, and the number of blood vessels. Capsule thickness appeared not to decrease with time. Further, these measurements showed that there were no differences in tissue reaction between smooth and microgrooved implants. On the basis of our observations, we suggest that 1 microm deep and 1-10 microm wide microgrooves do not influence tissue response around polystyrene implants in soft tissue.
Walboomers
X F
XF
Department of Biomaterials, Dental School, Faculty of Medical Sciences, University of Nijmegen, The Netherlands. F.Walboomers@dent.kun.NL
Croes
H J
HJ
Ginsel
L A
LA
Jansen
J A
JA
D000818:Animals; D001672:Biocompatible Materials; D003094:Collagen / Q000032:analysis; D005260:Female; D006041:Goats; D007249:Inflammation; D008855:Microscopy, Electron, Scanning; D009389:Neovascularization, Pathologic; D011137:Polystyrenes / Q000737:chemistry; D019736:Prostheses and Implants; D012867:Skin / Q000098:blood supply / Q000473:pathology* / Q000648:ultrastructure
D001672:Biocompatible Materials; D011137:Polystyrenes; D003094:Collagen