title: Protein and lipid sorting between the endoplasmic reticulum and the Golgi complex.
abstract: Vesicular traffic within the early secretory pathway is mediated by COPI- and COPII-coated vesicles. While COPII-coated vesicles appear to be involved exclusively in the export of secretory proteins and lipids from the endoplasmic reticulum (ER), COPI-coated vesicles seem to function in both anterograde and retrograde transport between the ER-Golgi intermediate compartment (IC) and the Golgi as well as in intra-Golgi transport. Here, we focus on (i) the mechanisms how these transport carriers are formed from a given donor membrane; and (ii) the possible mechanisms involved in sorting of proteins and lipids into such transport vesicles.
authors.affiliation: Cellular Biochemistry and Biophysics Program, Rockefeller Research Laboratories, Memorial Sloan Kettering Cancer Center, New York, NY, 10021, USA.
authors.forename: W
authors.initials: W
authors.lastname: Nickel
authors.forename: B
authors.initials: B
authors.lastname: Brügger
authors.forename: F T
authors.initials: FT
authors.lastname: Wieland
mesh_terms: D001692:Biological Transport / Q000502:physiology*; D022181:COP-Coated Vesicles; D002352:Carrier Proteins / Q000502:physiology*; D002784:Cholesterol / Q000378:metabolism; D018699:Coated Vesicles / Q000502:physiology; D020756:Coatomer Protein; D018870:Endoplasmic Reticulum, Rough / Q000502:physiology*; D005057:Eukaryotic Cells / Q000502:physiology* / Q000648:ultrastructure; D005656:Fungal Proteins / Q000502:physiology*; D019204:GTP-Binding Proteins / Q000502:physiology*; D020690:GTPase-Activating Proteins; D006056:Golgi Apparatus / Q000502:physiology*; D006160:Guanosine Triphosphate / Q000502:physiology; D046911:Macromolecular Substances; D008563:Membrane Lipids / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism* / Q000502:physiology*; D008954:Models, Biological; D020559:Monomeric GTP-Binding Proteins; D028861:Nuclear Pore Complex Proteins; D010750:Phosphoproteins / Q000502:physiology*; D011506:Proteins / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins; D013109:Sphingomyelins / Q000378:metabolism; D033921:Vesicular Transport Proteins
chemical_list: D002352:Carrier Proteins; D020756:Coatomer Protein; D005656:Fungal Proteins; D020690:GTPase-Activating Proteins; D046911:Macromolecular Substances; D008563:Membrane Lipids; D008565:Membrane Proteins; D028861:Nuclear Pore Complex Proteins; D010750:Phosphoproteins; D011506:Proteins; C079620:SEC13 protein, S cerevisiae; C079037:SEC23 protein, S cerevisiae; C106113:SEC31 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D013109:Sphingomyelins; D033921:Vesicular Transport Proteins; D006160:Guanosine Triphosphate; D002784:Cholesterol; D019204:GTP-Binding Proteins; D020559:Monomeric GTP-Binding Proteins; C077395:SAR1 protein, S cerevisiae