A new tetracycline resistance determinant cloned from Proteus mirabilis.
The chromosomal inducible Tcr determinant from Proteus mirabilis was cloned and the nucleotide sequence of both the structural and repressor genes determined. The deduced amino acid sequence of the structural protein shows the highest similarity to TetA(H) from Pasteurella multocida (78.4%), followed by TetA(B) from Tn10 (50.9%). Based on this analysis, we suggest that this new determinant can be assigned to a new class, TetJ.
Magalhães
V D
VD
Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Botucatú, 862 3 degrees andar, São Paulo, SP 04023-062, Brazil.
Schuman
W
W
Castilho
B A
BA
D000595:Amino Acid Sequence; D017920:Antiporters / Q000737:chemistry / Q000235:genetics*; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics*; D001483:Base Sequence; D008969:Molecular Sequence Data; D011513:Proteus mirabilis / Q000235:genetics*; D016415:Sequence Alignment; D013753:Tetracycline Resistance / Q000235:genetics*
D017920:Antiporters; D001426:Bacterial Proteins; C079051:tetA protein, Bacteria