No evidence for radiation-induced clastogenic factors after in vitro or in vivo exposure of human blood.
Experiments were performed with human plasma irradiated in vitro or in vivo in order to evaluate the extent to which clastogenic factors might disturb the adaptive response to DNA-damaging factors currently studied in our laboratory. The studies were carried out with plasma isolated from whole blood given 4 Gy of X-rays in vitro and with plasma from people receiving local radiotherapy at a total dose of about 60 Gy gamma rays. Addition of irradiated plasma to culture medium did not result in a statistically significant increase in structural aberrations in chromosomes of non-irradiated normal blood.
Léonard
A
A
Teratogenicity and Mutagenicity Laboratory, Catholic University of Louvain, Avenue E. Mounier 72, UCL 7237, Brussels 1200, Belgium. leonard@farm.ucl.ac.be
Léonard
E D
ED
Gerber
G B
GB
Crutzen-Fayt
M C
MC
Richard
F
F
Gueulette
J G
JG
Akhmatullina
N B
NB
D000017:ABO Blood-Group System; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D008297:Male; D010949:Plasma / Q000528:radiation effects*; D011879:Radiotherapy Dosage; D012204:Rh-Hr Blood-Group System
D000017:ABO Blood-Group System; D012204:Rh-Hr Blood-Group System