Muscle development: electrical control of gene expression.
The electrical activity resulting from stimulation by motor neurons regulates gene expression in skeletal muscle fibres. A recent study has suggested a mechanism by which distinct patterns of electrical stimulus might be integrated to control the contractile properties of these fibres.
Hughes
S M
SM
MRC Muscle and Cell Motility Unit Developmental Biology Research Centre The Randall Institute King's College London 26-29 Drury Lane London WC2B 5RL UK. simon.hughes@kcl.ac.uk.
D000818:Animals; D019703:Calcineurin / Q000502:physiology; D004268:DNA-Binding Proteins / Q000502:physiology; D004594:Electrophysiology; D005786:Gene Expression Regulation; D006801:Humans; D009046:Motor Neurons / Q000502:physiology; D009119:Muscle Contraction / Q000235:genetics / Q000502:physiology; D024510:Muscle Development; D018656:Muscle Fibers, Fast-Twitch / Q000502:physiology; D018657:Muscle Fibers, Slow-Twitch / Q000502:physiology; D018482:Muscle, Skeletal / Q000254:growth & development* / Q000294:innervation* / Q000502:physiology; D050778:NFATC Transcription Factors; D009687:Nuclear Proteins; D014157:Transcription Factors / Q000502:physiology
D004268:DNA-Binding Proteins; D050778:NFATC Transcription Factors; D009687:Nuclear Proteins; D014157:Transcription Factors; D019703:Calcineurin