Chemical basis for alkali cation selectivity in potassium-channel proteins.
The determination of the crystal structure of a K+-selective channel protein from Streptomyces lividans reveals how the rapid movement of K+ across membranes is catalyzed by a large family of pore-forming proteins. Many features of the structure mirror hypotheses, predictions and models of K+ channels developed over the past four decades of functional analysis.
Moczydlowski
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Department of Pharmacology Department of Cellular and Molecular Physiology Yale University School of Medicine New Haven Connecticut 06520-8066 USA. edward.moczydlowski@yale.edu.
D000595:Amino Acid Sequence; D000818:Animals; D002412:Cations; D006801:Humans; D008969:Molecular Sequence Data; D015221:Potassium Channels / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry
D002412:Cations; D015221:Potassium Channels; D011506:Proteins