title: [HLA-DR:DQ genotypes and insulin-dependent diabetes in Senegal].
abstract: At the opposite of HLA-DR, HLA-DQ was not well documented in homogeneous negroïd populations. So, 93 IDDM and 115 control patients, all black senegalese people, were studied. The results showed three HLA-DQ IDDM-related susceptibility genotypes and also a high risk conferred by HLA-DR4/DR9 usually described in Mongoloïd people. Furthermore, DR:DQ associations allowed the identification of three IDDM predisposition genotypes, each of them with a characteristic mean age for disease diagnosis.
authors.affiliation: Laboratoire de Physique Pharmaceutique-Faculté de Médecine et de Pharmacie, Université Cheikh Anta DIOP, Dakar, Sénegal.
authors.forename: A
authors.initials: A
authors.lastname: Cisse
authors.forename: M
authors.initials: M
authors.lastname: Chauffert
authors.forename: C
authors.initials: C
authors.lastname: Julier
authors.forename: D
authors.initials: D
authors.lastname: Chevenne
authors.forename: S
authors.initials: S
authors.lastname: Michel
authors.forename: F
authors.initials: F
authors.lastname: Trivin
authors.forename: S N
authors.initials: SN
authors.lastname: Diop
authors.forename: E H
authors.initials: EH
authors.lastname: Sidibe
authors.forename: A M
authors.initials: AM
authors.lastname: Sow
mesh_terms: D000328:Adult; D044383:Black People / Q000235:genetics*; D016022:Case-Control Studies; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005260:Female; D005820:Genetic Testing; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D012675:Senegal
chemical_list: D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens
vernacular_title: Génotypes HLA-DR:DQ et diabète insulino-dépendant en milieu sénégalais.