Does essential hypertension cause progressive renal disease?
In the distant past, terminal renal failure occurred mainly as a result of malignant hypertension. The introduction of effective antihypertensive therapy has made malignant hypertension rare, and researchers have stopped focusing on the kidney's role in their hypertension research. However, recent long-term observational studies have documented an impressive relationship between hypertension and impaired renal function in patients without primary chronic renal disease; elderly and African American individuals with hypertension have the worst prognoses. The hallmark of hypertensive renal injury is thought to be a progressive increase in intrarenal vascular resistance, which may precede changes in renal structure. Because we lack evidence from renal biopsy studies, it is unclear whether an increase in albumin (protein) excretion correlates with these disturbances of renal function and structure. Nevertheless, because urinary excretion of albumin in patients with essential hypertension is related to the risk of cardiovascular complications, its measurement provides important clinical information.
Fliser
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D
Department of Internal Medicine, Ruperto-Carola University, Heidelberg, Germany.
Ritz
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E
D000419:Albuminuria / Q000652:urine; D000818:Animals; D018450:Disease Progression; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000150:complications*; D007674:Kidney Diseases / Q000209:etiology* / Q000503:physiopathology* / Q000652:urine; D011507:Proteinuria / Q000652:urine; D012079:Renal Circulation / Q000502:physiology