(1-->3)-beta-D-glucan and endotoxin modulate immune response to inhaled allergen.
Exposure to dust may involve co-exposure to agents which are allergens, together with those which are pro-inflammatory. To study the effects of such a co-exposure, the humoral and inflammatory responses were studied in guinea pigs inhaling the T-cell-dependent antigen ovalbumin (OVA) and the inflammatory agents (1 --> 3)-beta-D-glucan and lipopolysaccharide (LPS). The effects were evaluated as inflammatory cells in the lung and serum antibodies to OVA. LPS caused a stimulation of the OVA-induced antibody production which was abolished by simultaneous exposure to (1 --> 3)-beta-D-glucan. An increase of eosinophils after OVA exposure was decreased by co-exposure to (1 --> 3)-beta-D-glucan. The results demonstrate a complex interaction between adaptive and innate immune mechanisms in the lung, determined by exposure to common contaminants in airborne dust.
Rylander
R
R
Department of Environmental Medicine, University of Gothenburg, Sweden.
Holt
P G
PG
D000280:Administration, Inhalation; D000485:Allergens / Q000276:immunology*; D000818:Animals; D000906:Antibodies / Q000097:blood; D005260:Female; D005936:Glucans / Q000276:immunology*; D006168:Guinea Pigs; D008070:Lipopolysaccharides / Q000276:immunology*; D008168:Lung / Q000276:immunology; D008297:Male; D010047:Ovalbumin / Q000276:immunology*; D047071:beta-Glucans
D000485:Allergens; D000906:Antibodies; D005936:Glucans; D008070:Lipopolysaccharides; D047071:beta-Glucans; D010047:Ovalbumin; C033363:beta-1,3-glucan