title: Retrograded high-amylose corn starch reduces cholic acid excretion from the small bowel in ileostomy subjects.
abstract: OBJECTIVE
  To study the short-term effect of resistant starch (RS) from retrograded high-amylose corn starch (HACS) on the excretion of bile acids and nutrients from the small bowel in humans.
  
  
  METHODS
  Seven healthy ileostomists were given a controlled, constant diet during three days. On days 2 and 3, 100 g/d of one of two test-products--drum-dried ordinary corn starch and autoclaved retrograded HACS, providing 5 and 39 g RS/d, respectively--was given, in random order. Ileostomy effluents were collected for 24 h per day and analysed for wet weight, dry weight, energy, bile acids and nutrients.
  
  
  METHODS
  In-patient study at the metabolic ward, Department of Clinical Nutrition, Sahlgrenska University Hospital, Göteborg.
  
  
  RESULTS
  Consumption of retrograded HACS caused (1) a 42% lower mean excretion of cholic acid (P = 0.024); (2) a 42% lower mean wet weight concentration of bile acids (P < 0.001); (3) a 70% increased excretion of dry weight (P = 0.001); and (4) a 41% increased excretion of energy (P= 0.036) compared with consumption of drum-dried ordinary corn starch.
  
  
  CONCLUSIONS
  The reduced ileal excretion and concentration of cholic acid would be protective regarding colon cancer risk in addition to the increased fermentation substrate provided by RS and other energy-yielding components.
authors.affiliation: Department of Clinical Nutrition, Göteborg University, Sahlgrenska University Hospital, Sweden.
authors.forename: A M
authors.initials: AM
authors.lastname: Langkilde
authors.forename: H
authors.initials: H
authors.lastname: Ekwall
authors.forename: I
authors.initials: I
authors.lastname: Björck
authors.forename: N G
authors.initials: NG
authors.lastname: Asp
authors.forename: H
authors.initials: H
authors.lastname: Andersson
mesh_terms: D000328:Adult; D000688:Amylose / Q000008:administration & dosage*; D019826:Cholic Acid / Q000378:metabolism*; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D007081:Ileostomy; D007421:Intestine, Small / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D013213:Starch / Q000008:administration & dosage*; D003313:Zea mays
chemical_list: D004040:Dietary Carbohydrates; D013213:Starch; D000688:Amylose; D019826:Cholic Acid