Acute side effects of iopromide and diatrizoate in urography.
OBJECTIVE
In a prospective study, we compared the acute (0-2 h) side effects of ionic and nonionic contrast media in 767 patients undergoing intravenous urography.


METHODS
A nonionic contrast medium (iopromide) was compared to an ionic contrast medium (diatrizoate).


RESULTS
Side effects occurred in 25 patients (7.9%) receiving iopromide and in 104 patients (23.1%) receiving diatrizoate (p < 0.01). The reactions in the iopromide group were mild in 11 patients, moderate in 5, and severe in 1. The reactions were 83, 19 and 2, respectively, in the diatrizoate group. The number of reactions that required treatment was equal in the two groups (p > 0.05).


CONCLUSIONS
At intravenous urography, iopromide induced fewer side effects compared to diatrizoate.
Sahin
H
H
Department of Urology, Dicle University, Faculty of Medicine, Diyarbakir, Turkey.
Bircan
M K
MK
Akay
A F
AF
Kuru
A F
AF
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D003287:Contrast Media / Q000008:administration & dosage / Q000009:adverse effects*; D003973:Diatrizoate / Q000008:administration & dosage / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D007472:Iohexol / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014567:Urography
D003287:Contrast Media; D003973:Diatrizoate; D007472:Iohexol; C038192:iopromide