title: Pyrazole analogues of prazosin.
abstract: A series of analogues of prazosin, in which 1-methyl or 1-phenylpyrazole moieties were substituted for the furan ring, were synthesized and studied for their alpha 1-adrenoceptor antagonist activity. The role of the five member heterocyclic substructures in determining the affinity for the alpha 1-receptor is briefly discussed.
authors.affiliation: Dipartimento di Scienza e Tecnologia del Farmaco, Università di Torino, Turin, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Ermondi
authors.forename: D
authors.initials: D
authors.lastname: Boschi
authors.forename: A
authors.initials: A
authors.lastname: Di Stilo
authors.forename: C
authors.initials: C
authors.lastname: Tironi
authors.forename: A
authors.initials: A
authors.lastname: Gasco
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D008958:Models, Molecular; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D011224:Prazosin / Q000031:analogs & derivatives*; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000317:Adrenergic alpha-Antagonists; D011720:Pyrazoles; D011224:Prazosin