title: Methionine induces sexual development in the fission yeast Schizosaccharomyces pombe via an ste11-dependent signalling pathway.
abstract: Methionine added to minimal medium overcomes the repressing effects of ammonium and cyclic AMP (cAMP) on sexual development and efficiently induces mating and sporulation in homothallic strains of Schizosaccharomyces pombe. In heterothallic strains it induces G1 arrest when cells enter stationary phase. We show that methionine reduces the intracellular cAMP pool and induces the expression of at least two cAMP-repressible genes, including fbp1 and ste11. The easiest interpretation of the results is that methionine induces sexual development via a cAMP-dependent ste11 signalling pathway.
authors.affiliation: Institute of General Microbiology, University of Bern, CH-3012 Bern, Switzerland.
authors.forename: A M
authors.initials: AM
authors.lastname: Schweingruber
authors.forename: N
authors.initials: N
authors.lastname: Hilti
authors.forename: E
authors.initials: E
authors.lastname: Edenharter
authors.forename: M E
authors.initials: ME
authors.lastname: Schweingruber
mesh_terms: D003001:Cloning, Molecular; D000242:Cyclic AMP / Q000378:metabolism; D006597:Fructose-Bisphosphatase; D005656:Fungal Proteins / Q000235:genetics / Q000502:physiology*; D016193:G1 Phase / Q000187:drug effects; D005800:Genes, Fungal; D008715:Methionine / Q000494:pharmacology*; D008969:Molecular Sequence Data; D029701:Saccharomyces cerevisiae Proteins; D012568:Schizosaccharomyces / Q000187:drug effects* / Q000235:genetics / Q000502:physiology*; D029702:Schizosaccharomyces pombe Proteins; D015398:Signal Transduction; D013172:Spores, Fungal / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*
chemical_list: D005656:Fungal Proteins; D029701:Saccharomyces cerevisiae Proteins; D029702:Schizosaccharomyces pombe Proteins; D014157:Transcription Factors; C071596:ste11 protein, S pombe; D008715:Methionine; D000242:Cyclic AMP; C111172:FBP1 protein, S cerevisiae; D006597:Fructose-Bisphosphatase