title: Prolonged suppressed thyroid-stimulating hormone levels in hyperthyroidism in a neonate born to a mother with Graves' disease.
abstract: We report here a case of neonatal hyperthyroidism born to a mother, whose pregnancy was complicated by poorly controlled Graves' disease. The patient demonstrated exophthalmos and marked goiter at birth, indicating the existence of thyrotoxicosis in utero. The mother's Graves' disease was well controlled in the third trimester, resulting in a slightly lower level of free thyroxine (FT4) in the umbilical cord blood serum; however, thyroid-stimulating hormone (TSH) was undetectable. Thyroid-stimulating hormone remained undetectable for 2 months, while FT4 levels varied in the course. This case suggests that severe and prolonged thyrotoxicosis in utero, due to poor control of pregnancy with Graves' disease, might induce unresponsiveness of the hypothalamo-pituitary system in the newborn.
authors.affiliation: Department of Pediatrics, Mizonokuchi Hospital, Teikyo University School of Medicine, Kawasaki, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hojo
authors.forename: N
authors.initials: N
authors.lastname: Momotani
authors.forename: N
authors.initials: N
authors.lastname: Ikeda
authors.forename: A
authors.initials: A
authors.lastname: Ueda
authors.forename: K
authors.initials: K
authors.lastname: Uno
authors.forename: T
authors.initials: T
authors.lastname: Ishikita
authors.forename: A
authors.initials: A
authors.lastname: Ishiguro
authors.forename: T
authors.initials: T
authors.lastname: Shimbo
mesh_terms: D005260:Female; D006111:Graves Disease / Q000503:physiopathology*; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood* / Q000151:congenital*; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D013963:Thyroid Hormones / Q000097:blood; D013972:Thyrotropin / Q000097:blood*
chemical_list: D013963:Thyroid Hormones; D013972:Thyrotropin