title: Necrobiosis lipoidica-like skin lesions in systemic sarcoidosis.
abstract: A 62-year-old woman with systemic sarcoidosis developed erythematous plaques on her lower legs. Clinically, two kinds of skin lesions were distinguished; one type formed brownish-red plaques with induration suggesting plaque-type skin sarcoid, and the other formed purplish erythematous plaques with atrophic centers resembling necrobiosis lipoidica. In spite of this clinical appearance, a biopsy specimen from one of the latter lesions revealed typical skin sarcoid histology composed of discrete non-caseating granulomas, while that from one of the other lesions showed necrobiotic changes of collagen bundles surrounded by epitheloid histiocytes and foreign-body giant cells. Because cutaneous involvement of sarcoidosis may mimic necrobiosis lipoidica clinically and/or histologically, we diagnosed her skin lesions as necrobiosis-like skin sarcoid.
authors.affiliation: Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Igawa
authors.forename: R
authors.initials: R
authors.lastname: Maruyama
authors.forename: T
authors.initials: T
authors.lastname: Satoh
authors.forename: H
authors.initials: H
authors.lastname: Yokozeki
authors.forename: I
authors.initials: I
authors.lastname: Katayama
authors.forename: K
authors.initials: K
authors.lastname: Nishioka
mesh_terms: D003094:Collagen; D003937:Diagnosis, Differential; D005260:Female; D015743:Giant Cells, Foreign-Body / Q000473:pathology; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D007868:Leg Dermatoses / Q000473:pathology; D008875:Middle Aged; D009335:Necrobiosis Lipoidica / Q000473:pathology*; D012507:Sarcoidosis / Q000473:pathology*; D012871:Skin Diseases / Q000473:pathology*
chemical_list: D003094:Collagen