title: Ovarian steroid modulation of neurokinin contents in hypothalamus, pituitary, trigeminal nucleus, and cervical spinal cord of the ovariectomized female rat.
abstract: Ovariectomized rats were treated with estradiol benzoate (EB) and progesterone in conditions known to negatively and positively regulate gonadotropin secretion. Injection with EB decreased the plasma concentration of substance P at the time of the positive feed-back exerted by EB on gonadotropin secretion, while having no effect on the plasma concentration of neurokinin A. In the hypothalamus, EB injection enhanced the substance P and neurokinin A content, while progesterone reduced the substance P content. In the anterior pituitary, the substance P content was increased after progesterone, and this increase was blocked by EB. Conversely, in the posterior pituitary, the substance P content was reduced after progesterone, and this effect was enhanced by EB. In the trigeminal nucleus, the substance P content was increased after progesterone and EB, while only progesterone affected neurokinin A content. Finally, in the cervical spinal cord, the substance P and neurokinin A contents were reduced after EB. We conclude that neurokinin contents are controlled by ovarian steroids not only in the hypothalamo-pituitary complex but also in the trigeminal nucleus and the cervical spinal cord.
authors.affiliation: Laboratoire de Neurobiologie Cellulaire et Moléculaire, CNRS EP 1591, Faculté des Sciences Pharmaceutiques et Biologiques, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Duval
authors.forename: V
authors.initials: V
authors.lastname: Lenoir
authors.forename: B
authors.initials: B
authors.lastname: Kerdelhue
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000378:metabolism*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007031:Hypothalamus / Q000378:metabolism; D007986:Luteinizing Hormone / Q000097:blood; D009333:Neck; D015288:Neurokinin A / Q000378:metabolism*; D009994:Osmolar Concentration; D010052:Ovariectomy; D010902:Pituitary Gland / Q000378:metabolism; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013116:Spinal Cord / Q000378:metabolism; D013373:Substance P / Q000378:metabolism*; D014278:Trigeminal Nuclei / Q000378:metabolism
chemical_list: D013373:Substance P; D011374:Progesterone; D004958:Estradiol; D015288:Neurokinin A; D007986:Luteinizing Hormone