Rapid detection of dihydrocodeine by thermospray mass spectrometry.
Rapid assay of dihydrocodeine (DHC) by thermospray mass spectrometry is explored. Liquid-liquid extractions of blood, urine and gastric contents were injected into a thermospray mass spectrometer, to which there was no column connected, and DHC was assayed by the flow injection method. The mass spectra of DHC under thermospray ionization and filament-on ionization modes consist of the MH+ ion of mlz 302 alone, which was clearly detected in the samples. Although DHC should be quantitated by gas chromatography-mass spectrometry, this method is applicable for rapid identification of DHC in biological materials.
Yoshida
M
M
Department of Legal Medicine, Kansai Medical University, Moriguchi, Japan.
Akane
A
A
Okii
Y
Y
Yoshimura
S
S
Tokiyasu
T
T
Watabiki
T
T
D003061:Codeine / Q000031:analogs & derivatives* / Q000032:analysis; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods*
C014481:dihydrocodeine; D003061:Codeine