[Drug-induced osteomalacia].
The osteomalacia is a metabolic bone disease, characterized by a defect of bone mineralization, due to a lot of causes; among these an important role may be attributed to some drugs. The drugs most frequently associated with osteomalacia are: cholestyramine, phenytoin, phenobarbital, rifampicin, isoniazid, aluminium-containing antacid, saccharated ferric oxide, cadmium, lead, bisphosphonates, fluoride and aluminum. In this review we discuss about the pathophysiologic mechanisms related to drug-induced osteomalacia involving vitamin D metabolism, phosphorus homeostasis and bone mineralization.
D'Erasmo
E
E
Cattedra di Medicina Interna, Policlinico Umberto I, Università La Sapienza, Roma.
Ragno
A
A
Raejntroph
N
N
Pisani
D
D
D064420:Drug-Related Side Effects and Adverse Reactions; D006706:Homeostasis; D006801:Humans; D008903:Minerals / Q000378:metabolism; D010018:Osteomalacia / Q000139:chemically induced* / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism; D014807:Vitamin D / Q000378:metabolism
D008903:Minerals; D014807:Vitamin D; D010758:Phosphorus
Osteomalacia da farmaci.