Expression of growth arrest and DNA damage genes and DNA mismatch repair genes in snake melanomas.
Snake melanomas are rare tumours and their pathogenesis is still unclear. In this study the expression of DNA mismatch repair genes and Growth Arrest DNA Damage Genes was investigated. The expression only of 3 of them GADD34, MLH1 and MSH2 was found. The role of these genes in animal tumorigenesis is discussed.
Korabiowska
M
M
Department of Cytopathology, Georg August University Göttingen, Germany.
Brinck
U
U
Frye
F L
FL
Harshbarger
J C
JC
Droese
M
M
Kaiser
H E
HE
D000818:Animals; D004249:DNA Damage / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics*; D004273:DNA, Neoplasm / Q000032:analysis / Q000235:genetics*; D004268:DNA-Binding Proteins; D017809:Fatal Outcome; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor / Q000235:genetics*; D008545:Melanoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D051718:MutS Homolog 2 Protein; D009363:Neoplasm Proteins / Q000378:metabolism; D009687:Nuclear Proteins; D011506:Proteins / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D012878:Skin Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D012911:Snakes
D004273:DNA, Neoplasm; D004268:DNA-Binding Proteins; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D011506:Proteins; D011518:Proto-Oncogene Proteins; D051718:MutS Homolog 2 Protein