Pulmonary and cardiovascular effects of acute exposure to concentrated ambient particulate matter in rats.
To examine the biological plausibility of the adverse health effects of ambient particulate matter (PM), we have studied the cardio-pulmonary effects of PM in an animal model of pulmonary hypertension. Normal and monocrotaline-treated rats were exposed, nose-only, for 3 h to filtered air or concentrated ambient PM. At 3 h--but not 24 h--post-exposure, the percentage of neutrophils in peripheral blood was significantly elevated in PM-exposed animals while the percentage of lymphocytes was decreased with no change in white blood cell counts. These changes in white blood cell differential occurred in both normal and monocrotaline-treated animals. Small, but consistent changes in heart rate, but not core temperature, were observed after exposure to concentrated ambient PM. Pulmonary injury, as evidenced by increased protein levels in lavage fluid, occurred only in monocrotaline-treated animals exposed to > 360 microg/m3 PM. The observed pattern of hematological and cardiac changes suggests an activation of the sympathetic stress response.
Gordon
T
T
Department of Environmental Medicine, New York University School of Medicine, Tuxedo 10987, USA. gordont@charlotte.med.nyu.edu
Nadziejko
C
C
Schlesinger
R
R
Chen
L C
LC
D000393:Air Pollutants / Q000633:toxicity*; D016902:Air Pollution, Indoor / Q000009:adverse effects*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D004195:Disease Models, Animal; D006339:Heart Rate / Q000187:drug effects; D006976:Hypertension, Pulmonary / Q000139:chemically induced / Q000503:physiopathology; D007958:Leukocyte Count / Q000187:drug effects; D008168:Lung / Q000187:drug effects*; D016686:Monocrotaline; D010316:Particle Size; D051381:Rats; D015203:Reproducibility of Results
D000393:Air Pollutants; D016686:Monocrotaline