Integrin associated proteins.
Integrin cytoplasmic domains may interact directly with serveral different cytoskeletal proteins and intracellular signaling molecules. Also, integrins interact directly with other transmembrane structures, including transmembrane-4 superfamily (TM4SF) proteins. New evidence suggests that TM4SF proteins may act as linkers between extracellular integrin alpha chain domains and intracellular signaling molecules, such as phosphatidylinositol 4-kinase and protein kinase C.
Hemler
M E
ME
Dana-Farber Cancer Institute, Boston, MA 02115, USA. martin_hemler@dfci.harvard.edu
D002462:Cell Membrane / Q000737:chemistry; D016764:Cell Polarity; D003598:Cytoskeletal Proteins / Q000378:metabolism; D016023:Integrins / Q000502:physiology*; D008565:Membrane Proteins / Q000378:metabolism; D008954:Models, Biological; D018832:Molecular Chaperones / Q000378:metabolism; D011485:Protein Binding; D015398:Signal Transduction
D003598:Cytoskeletal Proteins; D016023:Integrins; D008565:Membrane Proteins; D018832:Molecular Chaperones