[Plasminogen activator inhibitor (PAI-1) and diabetes mellitus. II. PAI-1 in insulin resistant conditions].
Insulin resistance (IR) is associated with an elevated PAI-1 level and by correlation with insulin and triacylglycerol (TG) levels. While in IR non-diabetics this relationship is close, in patients with NIDDM the mutual relationship is less marked and there are other factors which raise the PAI-1 levels such as proinsulin, oxidation stress or cytokines. Therefore achievement of satisfactory metabolic control, reduction of insulin and TG levels need not be associated with normalization of PAI-1. As it is an independent risk factor of atherosclerosis, further examinations are necessary in order to differentiate in more detail the possible causes of its rising level in order to obtain a rational basis for effective therapy.
Galajda
P
P
I. interná klinika MFN, Martin.
Sutarík
L
L
Vladár
L
L
Stasko
J
J
Kubisz
P
P
Mokán
M
M
D003920:Diabetes Mellitus / Q000097:blood*; D006801:Humans; D007333:Insulin Resistance; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*
D017395:Plasminogen Activator Inhibitor 1
Inhibítor plazminogénového aktivátora (PAI-1) a diabetes mellitus. II. PAI-1 pri inzulínrezistentných stavoch.