[Evaluation of the enhaled glucocorticosteroid effect on non-specific and specific bronchial reactivity with particular reference to the late inflammatory phase in atopic asthma patients. I. The effect of a single dose of budesonide R on specific and non-specific bronchial reactivity].
The effect of a single dose of 320 micrograms of budesonide R on specific and non-specific bronchial response was evaluated. The study was carried out on a group of 12 patients suffering from mild allergic asthma, sensitive to Dermatophagoides pteronyssinus (D. pteronyssinus). On the first day the bronchial provocation test (BPT) with metacholine was performed, and the next day the effect of a single dose of the drug studied on bronchial response to metacholine was evaluated. On the third day sBPT with D. pteronyssinus allergen was performed. The allergen challenge could induce an early (EAR) and a late asthmatic reaction (LAR). After the BPT with the allergen, a 42 days' run-out period was required to eliminate the effects of the allergen provocation on the results of the next tests. Before the evaluation of the effect of budesonide on the allergen challenge, the non-specific response to metacholine was checked again. The results indicate that a single dose of budesonide R does not affect non-specific and specific bronchial response.
Chyrek-Borowska
S
S
Kliniki Alergologii i Chorób Wewnetrznych Akademii Medycznej w Białymstoku.
Siergiejko
Z
Z
Rogalewska
A
A
Zietkowski
Z
Z
D000328:Adult; D001249:Asthma / Q000150:complications* / Q000188:drug therapy*; D001980:Bronchi / Q000187:drug effects*; D001985:Bronchial Provocation Tests; D019819:Budesonide / Q000494:pharmacology* / Q000627:therapeutic use; D003876:Dermatitis, Atopic / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008297:Male
D005938:Glucocorticoids; D019819:Budesonide
Wpływ wziewnych glikokortykosteroidów na nieswoista i poalergenowa reaktywność oskrzeli ze szczególnym uwzglednieniem późnej fazy zapalnej u chorych na atopowa astme oskrzelowa. I. Wpływ pojedynczej dawki budezonidu R na swoista i nieswoista reaktywność oskrzeli.