[Variations in interleukin-2 and interleukin-6 due to surgical trauma in cancer patients].
Inflammatory response after surgical trauma, which is necessary for infection control and tissue repairing, can actually produce some cytokines suppressive of the antitumoral immunity response. In this study the authors evaluate pre- and post-operative IL-2 (antitumor response activator) and IL-6 (lymphocytic response inhibitor and tumor growth factor) levels in 26 cancer patients undergoing resective surgery. Analysis of the results showed a significative IL-6 increase and a tendency to IL-2 decrease in the post-operative period. It is thus confirmed, even on the basis of the cytokines, the meaningful immunosuppressive effect of the surgical trauma on neoplastic growth control.
Brivio
F
F
III Clinica Chirurgica, Ospedale S. Gerardo, Monza, Terza Università degli Studi di Milano, Polo di Monza.
Perego
M
M
Mauri
E
E
Gramazio
F
F
Brivio
O
O
Gariboldi
G
G
Urso
G
G
Nespoli
A
A
D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D003082:Colectomy; D015179:Colorectal Neoplasms / Q000276:immunology* / Q000601:surgery; D005743:Gastrectomy; D006801:Humans; D007376:Interleukin-2 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008875:Middle Aged; D011184:Postoperative Period; D013274:Stomach Neoplasms / Q000276:immunology* / Q000601:surgery
D014408:Biomarkers, Tumor; D007376:Interleukin-2; D015850:Interleukin-6
Variazioni di interleuchina-2 e interleuchina-6 da trauma chirurgico in pazienti oncologici.