Antibodies to human myelin proteins and gangliosides in patients with acute neuroparalytic accidents induced by brain-derived rabies vaccine.
Antibody responses to myelin antigens were analysed in 15 patients who developed acute neuroparalytic accidents (ANPA) during post-exposure rabies vaccination using a rabies vaccine prepared on brain tissues and in 30 individuals who were uneventfully vaccinated. High titers (> or = 100) of IgG and IgM antibodies to GM1 or GD1a gangliosides were detected by enzyme linked immunosorbent-assay (ELISA) in plasmas from ANPA patients but not in controls. These data suggest that antibodies to GM1 and GD1a gangliosides may play a pathogenic role in the demyelinating and/or inflammatory processes characteristic of rabies vaccine-induced acute neurologic complications.
Laouini
D
D
Laboratory of Immunology, Institut Pasteur de Tunis, Tunis-Belvedère, Tunisia.
Kennou
M F
MF
Khoufi
S
S
Dellagi
K
K
D000328:Adult; D000914:Antibodies, Viral / Q000276:immunology*; D001923:Brain Chemistry / Q000276:immunology; D002648:Child; D002851:Chromatography, High Pressure Liquid; D004673:Encephalomyelitis, Acute Disseminated / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005677:G(M1) Ganglioside / Q000276:immunology*; D005732:Gangliosides / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D009185:Myelin Proteins / Q000032:analysis / Q000276:immunology*; D010243:Paralysis / Q000276:immunology / Q000821:virology; D011818:Rabies / Q000276:immunology*
D000914:Antibodies, Viral; D005732:Gangliosides; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D009185:Myelin Proteins; C021298:ganglioside, GD1a; D005677:G(M1) Ganglioside