title: Monte Carlo-aided dosimetry of a new high dose-rate brachytherapy source.
abstract: In this article we introduce a new high-intensity 192Ir source design for use in a recently reengineered microSelectron-HDR remote afterloading device for high dose-rate (HDR) brachytherapy. The maximum rigid length and outer diameter of the new source are reduced to 4.95 and 0.90 mm, respectively, compared to 5.50 and 1.10 mm for the previous source design introduced in 1991. In addition, a smaller diameter and more flexible steel cable are used, allowing the source cable to negotiate smaller diameter catheters or more tortuously curved catheters. Using Monte Carlo photon transport simulation, the complete two-dimensional (2-D) dose-rate distribution is calculated over the 0.1-7 cm distance range and are presented both as conventional 2-D Cartesian lookup tables and in the formalism recommended by the American Association of Physicists in Medicine Task Group 43 (TG-43) Report. The dose distribution of this source is very similar to that of its predecessor, except near the source tip and in the shadow of the cable assembly, where differences of 5%-8% are apparent. The accuracy of various methods for extrapolating beyond the tubulated anisotropy functions to short distances is evaluated. It is demonstrated that linear extrapolation from the anisotropy functions defined by TG-43 accurately (+/- 2%) estimates dose rate at short and long distances lying outside the radial distance range of the original measured data from which the anisotropy and radial dose functions were derived. In contrast, the algorithm used on the vendor's planning system results in large calculation errors at distances less than 5 mm.
authors.affiliation: Radiation Oncology Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
authors.forename: G M
authors.initials: GM
authors.lastname: Daskalov
authors.forename: E
authors.initials: E
authors.lastname: Löffler
authors.forename: J F
authors.initials: JF
authors.lastname: Williamson
mesh_terms: D016880:Anisotropy; D001918:Brachytherapy / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D007496:Iridium Radioisotopes / Q000627:therapeutic use*; D008962:Models, Theoretical; D009010:Monte Carlo Method; D017785:Photons; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results
chemical_list: D007496:Iridium Radioisotopes