Different effects of newly isolated saponins on the mutagenicity and cytotoxicity of the anticancer drugs mitomycin C and bleomycin in human lymphocytes.
Aim of the present paper was to assess by using the in vitro micronucleus (MN) test in human lymphocytes the effect of two plant extracts isolated from Blupeurum fruticosum (saponins) on the clastogenicity and cytotoxicity of the anticancer drugs mitomycin C (MMC) and bleomycin (BLM). One saponin showed a dose-dependent MMC-induced mutagenesis inhibition together with co-genotoxic effect on BLM-treated cultures. The remaining saponin did not significantly alter MN induction of both chemotherapeutic agents whereas it enhanced BLM cytotoxicity.
Scarpato
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R
Dipartimento di Scienze dell'Uomo e dell'Ambiente, Università di Pisa, Via San Giuseppe 22, 56100, Pisa, Italy.
Bertoli
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A
Naccarati
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Migliore
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L
Cocchi
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L
Barale
R
R
Pistelli
L
L
D000964:Antimetabolites, Antineoplastic / Q000633:toxicity*; D001761:Bleomycin / Q000633:toxicity*; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008214:Lymphocytes / Q000737:chemistry / Q000187:drug effects; D008297:Male; D015162:Micronucleus Tests; D016685:Mitomycin / Q000633:toxicity*; D009153:Mutagens / Q000494:pharmacology; D019384:Nucleic Acid Synthesis Inhibitors / Q000633:toxicity*; D010944:Plants / Q000737:chemistry; D012503:Saponins / Q000494:pharmacology*
D000964:Antimetabolites, Antineoplastic; D009153:Mutagens; D019384:Nucleic Acid Synthesis Inhibitors; D012503:Saponins; D001761:Bleomycin; D016685:Mitomycin