Antileukotrienes and asthma: alternative or adjunct to inhaled steroids?
Antileukotriene agents may be reasonable and safe alternatives or adjuncts to inhaled steroid therapy in chronic asthma, as they act at sites further down in the inflammatory cascade. This article reviews the clinical experience with three antileukotriene agents and discusses their role in the management of asthma.
Kavuru
M S
MS
Department of Pulmonary and Critical Care Medicine, Cleveland Clinic Foundation, OH 44195, USA.
Subramony
R
R
Vann
A R
AR
D000085:Acetates / Q000627:therapeutic use*; D000280:Administration, Inhalation; D000284:Administration, Oral; D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy*; D002648:Child; D015267:Churg-Strauss Syndrome / Q000139:chemically induced; D003521:Cyclopropanes; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006918:Hydroxyurea / Q000031:analogs & derivatives* / Q000627:therapeutic use; D007211:Indoles; D020024:Leukotriene Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D008111:Liver Function Tests / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D048448:Phenylcarbamates; D011804:Quinolines / Q000627:therapeutic use*; D013440:Sulfides; D013449:Sulfonamides; D014105:Tosyl Compounds / Q000009:adverse effects / Q000627:therapeutic use*; D014859:Warfarin / Q000494:pharmacology
D000085:Acetates; D000305:Adrenal Cortex Hormones; D018927:Anti-Asthmatic Agents; D003521:Cyclopropanes; D007211:Indoles; D020024:Leukotriene Antagonists; D048448:Phenylcarbamates; D011804:Quinolines; D013440:Sulfides; D013449:Sulfonamides; D014105:Tosyl Compounds; D014859:Warfarin; C093875:montelukast; C063449:zileuton; D006918:Hydroxyurea; C062735:zafirlukast