Extramedullary T lymphoblastic transformation of chronic myeloid leukaemia occurring after double allogeneic transplantation.
The clinical course of chronic myeloid leukaemia (CML) is characterised by a chronic phase followed by an acute phase or blast crisis. Lymphoid transformation accounts for 20-30% of such events, with the majority of cases being of B cell origin. Extramedullary transformation occurs in approximately 10% of cases. We report a case of T cell lymphoblastic transformation in CML presenting as an extramedullary mass after allogeneic stem cell transplant. This case supports the growing evidence that CML arises in the pluripotent stem cell.
Kell
J
J
Department of Haematology, University Hospital of Wales, Cardiff, UK.
Booth
M
M
Jones
B
B
Appleton
M
M
Lim
S
S
D000328:Adult; D002471:Cell Transformation, Neoplastic; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000473:pathology* / Q000628:therapy; D008297:Male; D013601:T-Lymphocytes / Q000473:pathology*; D014184:Transplantation, Homologous