Fibroblast growth factor (FGF)-9 immunoreactivity in senile plaques.
We examined fibroblast growth factor (FGF)-9 immunoreactivity in human hippocampal sections of Alzheimer's disease (AD). FGF-9 immunoreactivity was observed in dystrophic neurites of senile plaques in AD and control cases, in addition to the hippocampal and cortical neurons. The amyloid core and neurofibrillary tangles lacked immunoreactivity. FGF-9 immunoreactive astrocytes were conspicuous in AD brains. FGF-9 may be involved in the neuropathology of AD.
Nakamura
S
S
Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry, 2-1-8 Kamikitazawa, Setagaya, Tokyo 156-8585, Japan. snakamu@prit.go.jp
Arima
K
K
Haga
S
S
Aizawa
T
T
Motoi
Y
Y
Otsuka
M
M
Ueki
A
A
Ikeda
K
K
D000544:Alzheimer Disease / Q000378:metabolism*; D051525:Fibroblast Growth Factor 9; D005346:Fibroblast Growth Factors; D006133:Growth Substances / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D009419:Nerve Tissue Proteins / Q000032:analysis*; D016874:Neurofibrillary Tangles / Q000737:chemistry; D058225:Plaque, Amyloid / Q000737:chemistry*
C496459:FGF9 protein, human; D051525:Fibroblast Growth Factor 9; D006133:Growth Substances; D009419:Nerve Tissue Proteins; D005346:Fibroblast Growth Factors