Relation of serum total cholesterol, serum triglycerides and fasting plasma glucose to colorectal carcinoma in situ.
BACKGROUND
No one has previously examined the relation of serum total cholesterol, serum triglycerides and fasting plasma glucose to colorectal carcinoma in situ.


METHODS
A case-control study was performed with 129 cases of colorectal carcinoma in situ and 258 matched controls among examinees undergoing a health check-up in Tokyo from January 1991 to March 1993.


RESULTS
There was a significant, positive association between serum total cholesterol levels and the risk of colorectal carcinoma in situ after adjustment for age, sex, body mass index, smoking status and alcohol consumption. Serum triglyceride levels were significantly and positively associated with colorectal carcinoma in situ risk regardless of adjustment for the above covariates. Although there was no clear relation between colorectal carcinoma in situ and fasting plasma glucose levels, a modest increase of colorectal carcinoma in situ risk was observed in the highest category (> or =116 mg/dl) of fasting plasma glucose levels.


CONCLUSIONS
The findings suggest a positive association between serum total cholesterol levels and the risk of colorectal cancer, rather than an inverse relation. The strong association with serum triglyceride levels and the weak association with fasting plasma glucose levels support the hypothesis that hyperinsulinaemia may play an important role in colorectal carcinogenesis.
Yamada
K
K
PL Tokyo Health Care Center, Japan.
Araki
S
S
Tamura
M
M
Sakai
I
I
Takahashi
Y
Y
Kashihara
H
H
Kono
S
S
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis*; D002278:Carcinoma in Situ / Q000097:blood* / Q000453:epidemiology; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood*; D003110:Colonic Neoplasms / Q000097:blood* / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000097:blood* / Q000453:epidemiology; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*
D001786:Blood Glucose; D014280:Triglycerides; D002784:Cholesterol