TGF-beta and FGF-trigger intercellular induction of apoptosis: analogous activity on non-transformed but differential activity on transformed cells.
Transforming growth factor (TGF)-beta as well as fibroblast growth factor (FGF) are able to trigger intercellular induction of apoptosis. Interaction of either cytokine with non-transformed cells results in the production and release of apoptosis inducing factor (AIF) which is specifically directed against transformed cells. In both cases, AIF production is inhibited by the antioxidant N-Acetylcysteine, indicating that similar or identical signalling pathways are utilized. Whereas TGF-beta sensitizes transformed cells by down modulation of their endogenous survival factors, FGF is devoid of a similar activity. Therefore TGF-beta triggers and enhances intercellular induction of apoptosis by interaction with non-transformed and transformed cells, whereas the activity of FGF is based only on the interaction with non-transformed cells.
Dormann
S
S
Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D-79104 Freiburg, Germany.
Bauer
G
G
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002461:Cell Line, Transformed; D002478:Cells, Cultured; D005346:Fibroblast Growth Factors / Q000502:physiology*; D051381:Rats; D016212:Transforming Growth Factor beta / Q000502:physiology*
D016212:Transforming Growth Factor beta; D005346:Fibroblast Growth Factors