title: Efficacy of various inorganic sorbents to reduce the toxicity of aflatoxin and T-2 toxin in broiler chickens.
abstract: Experiments were conducted to determine the efficacy of three inorganic sorbents, S1, S2, and S3, to reduce the toxicity of aflatoxins (AF) and T-2 toxin in male broiler chickens from day of hatch to 21 d of age. The compounds had been reported to bind to AF and T-2 toxin in vitro. S1 and S2 were the same basic compound that had been stored for different lengths of time following activation. In Experiments 1, 2, and 3, the appropriate diets were produced to contain no mycotoxins, the specific adsorbent at 0.5% of diet, AF alone at 5 mg/kg of diet, T-2 alone at 8 mg/kg of diet, AF at 5 mg/kg of diet plus the specific sorbent at 0.5% of diet, or T-2 at 8 mg/kg of diet plus the specific sorbent at 0.5% of diet. The specific sorbents used were: 1) Experiment 1, S1; 2) Experiment 2, S1 and S2; and 3) Experiment 3, S3. In Experiments 1 and 3, S1 and S3, respectively, showed no protection against AF or T-2 toxin as measured by BW gain, when compared to AF alone group. In Experiment 2, S1 showed no protection; however S2 reduced the effects of AF on BW gain by 25% as compared to AF alone diet. The data demonstrate that under the conditions of our experiment: 1) one of the sorbents provided some protection against aflatoxicosis; 2) there was variability in protection against aflatoxicosis between two different samples of the same sorbent that had been stored for different lengths of time following activation; 3) protection by the sorbents against the effects of T-2 toxin was not observed.
authors.affiliation: USDA Agricultural Research Service, Food Animal Protection Research Laboratory, College Station, Texas 77845, USA.
authors.forename: R H
authors.initials: RH
authors.lastname: Bailey
authors.forename: L F
authors.initials: LF
authors.lastname: Kubena
authors.forename: R B
authors.initials: RB
authors.lastname: Harvey
authors.forename: S A
authors.initials: SA
authors.lastname: Buckley
authors.forename: G E
authors.initials: GE
authors.lastname: Rottinghaus
mesh_terms: D000327:Adsorption; D000469:Alkaline Phosphatase / Q000097:blood; D000538:Aluminum Silicates / Q000627:therapeutic use*; D000821:Animal Feed; D000818:Animals; D002118:Calcium / Q000097:blood; D002645:Chickens; D002784:Cholesterol / Q000097:blood; D005506:Food Contamination; D008297:Male; D015651:Mycotoxicosis / Q000517:prevention & control / Q000662:veterinary*; D010758:Phosphorus / Q000097:blood; D011201:Poultry Diseases / Q000139:chemically induced / Q000517:prevention & control*; D012709:Serum Albumin / Q000378:metabolism; D013605:T-2 Toxin / Q000506:poisoning*; D014527:Uric Acid / Q000097:blood; D000096702:Aflatoxin Poisoning
chemical_list: D000469:Alkaline Phosphatase; D000538:Aluminum Silicates; D002118:Calcium; D002784:Cholesterol; D010758:Phosphorus; D012709:Serum Albumin; D013605:T-2 Toxin; D014527:Uric Acid