[Current trends and prospects of fetal neurosurgery].
Fetal surgery failed up to now to correct early in gestation nervous system pathologies before an irreversible damage occurs. The major hindrance is the induction of preterm labour considered for fetal surgery what rejection is for organ transplantation. Pharmacological tocolytic control seems an essential step before a routine surgery is established. In the meanwhile miniinvasive endoscopic surgery holds out the best promises, minimizing fetal and maternal stress. There are many convincing experimental evidences that endoscopic surgery may prevent secondary neurological damage of spinal cord in the myelomeningocele. Vascularized latissimus dorsi muscle flap or skin graft were effectively used, with endoscopic techniques, to create a protective patch to preserve the nervous tissue from mechanical and/or chemical damage. Endoscopic implant of neurons-rich grafts in damaged cerebral sites, with beneficial behavioural effects and increased learning capacity in the recipient animal with respect to controls, disclose further perspectives to fetoscopic surgery.
Pastore
F S
FS
Istituto di Neurochirurgia, Università di Roma Tor Vergata.
Patricolo
M
M
De Caro
G M
GM
Giuffrè
R
R
D000818:Animals; D002557:Cerebrospinal Fluid Shunts; D002648:Child; D002675:Child, Preschool; D004724:Endoscopy; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging / Q000601:surgery; D005332:Fetoscopy; D005333:Fetus / Q000601:surgery*; D005500:Follow-Up Studies; D005865:Gestational Age; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D006849:Hydrocephalus / Q000000981:diagnostic imaging / Q000601:surgery; D007223:Infant; D007231:Infant, Newborn; D019060:Minimally Invasive Surgical Procedures; D009493:Neurosurgery; D011247:Pregnancy; D011323:Primates; D012756:Sheep; D013997:Time Factors; D016216:Ultrasonography, Prenatal
Attualità e prospettive della neurochirurgia fetale.