title: The auditory brainstem response of aged guinea pigs.
abstract: The auditory brainstem response (ABR) technique was used to investigate potential dysfunctions in the auditory brainstem of the pigmented guinea pig (Cavia porcellus) associated with biological ageing. Animals aged from 58 days to 4 years 3 months were tested. ABRs were recorded at stimulation intensities from 85 dB HL to -10 dB HL. The auditory thresholds were found to undergo marked elevations in old animals, by an average of 32 dB. From the traces obtained, four positive deflection waves were reliably recorded. The latency of each of the four waves was evaluated at different stimulation intensities in guinea pigs of different ages. Although there was a trend for the latencies to increase in old age, these differences were not statistically significant. Similarly, there were no significant age-related changes in the inter-peak intervals. The latency/intensity functions of the four waves produced parallel curves. However, the curve from the old age group was shifted to the right, by an average of 35 dB, indicative of conductive hearing loss. There was no evidence of retro-cochlear hearing loss. Therefore, it appears that the threshold elevations in the old animals can be accounted for by conductive hearing loss, presumably in the middle ear. In 24% of the old animals tested, no ABR could be elicited. It would appear that these animals had suffered severe sensorineural hearing loss.
authors.affiliation: Department of Physiology, Worsley Medical and Dental Building, University of Leeds, UK. n.j.ingham@leeds.ac.uk
authors.forename: N J
authors.initials: NJ
authors.lastname: Ingham
authors.forename: S K
authors.initials: SK
authors.lastname: Thornton
authors.forename: S D
authors.initials: SD
authors.lastname: Comis
authors.forename: D J
authors.initials: DJ
authors.lastname: Withington
mesh_terms: D000375:Aging / Q000502:physiology*; D000704:Analysis of Variance; D000818:Animals; D004566:Electrodes; D004594:Electrophysiology / Q000295:instrumentation / Q000379:methods / Q000706:statistics & numerical data; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D006168:Guinea Pigs; D011304:Presbycusis / Q000503:physiopathology; D018709:Statistics, Nonparametric