Recent advances in gene expression using alphavirus vectors.
Alphavirus vectors use RNA replication in the cell cytoplasm to direct gene expression. New developments of vectors put persistency of expression and infection of specific cells in focus. Furthermore, a new application shows that the system can be used for production of retrovirus vectors carrying genes with introns and control/regulatory regions.
Garoff
H
H
Department of Biosciences at Novum, Huddinge, Sweden. henrik.garoff@cbt.ki.se
Li
K J
KJ
D000524:Alphavirus / Q000235:genetics*; D000818:Animals; D001709:Biotechnology; D003588:Cytopathogenic Effect, Viral; D004274:DNA, Recombinant / Q000235:genetics; D015870:Gene Expression; D005822:Genetic Vectors; D006801:Humans; D012313:RNA / Q000235:genetics; D012093:Replicon; D012190:Retroviridae / Q000235:genetics
D004274:DNA, Recombinant; C039919:RNA, recombinant; D012313:RNA