Mouse mutagenesis: from gene to phenotype and back again.
Screens for genetic mutations have been instrumental in identifying genes needed to execute particular biological processes. They have also helped to resolve the function of individual genes. Now the notion of large-scale mutagenesis screens in mouse, an experimental model for humans, is becoming a reality.
Beddington
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MRC National Institute for Medical Research, The Ridgeway Mill Hill, London NW7 1AA, UK.
D000818:Animals; D005820:Genetic Testing; D006801:Humans; D051379:Mice; D008957:Models, Genetic; D016296:Mutagenesis; D010641:Phenotype