title: Squamous-cell carcinoma of the pelvis in a giant condyloma acuminatum: use of neoadjuvant chemoradiation and surgical resection: report of a case.
abstract: A 60-year-old bisexual male was referred to our institution for management of an unresectable squamous-cell carcinoma of the pelvis arising in a giant condyloma acuminatum. He received neoadjuvant chemoradiation consisting of 5-fluorouracil and mitomycin C with concurrent external beam radiation, followed by posterior pelvic exenteration. The surgical specimen had no residual cancer. In situ hybridization was performed using a human papilloma virus omniprobe for human papilloma virus subtypes 6, 11, 16, 18, 31, 33, and 35. Two years after diagnosis the patient is doing well with no evidence of recurrent disease.
authors.affiliation: Department of Surgical Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, USA.
authors.forename: M
authors.initials: M
authors.lastname: Hyacinthe
authors.forename: R
authors.initials: R
authors.lastname: Karl
authors.forename: D
authors.initials: D
authors.lastname: Coppola
authors.forename: T
authors.initials: T
authors.lastname: Goodgame
authors.forename: W
authors.initials: W
authors.lastname: Redwood
authors.forename: P
authors.initials: P
authors.lastname: Goldenfarb
authors.forename: N P
authors.initials: NP
authors.lastname: Ohori
authors.forename: J
authors.initials: J
authors.lastname: Marcet
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D003218:Condylomata Acuminata / Q000150:complications*; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D010385:Pelvic Exenteration; D010386:Pelvic Neoplasms / Q000150:complications* / Q000628:therapy*; D018714:Radiotherapy, Adjuvant
chemical_list: D000903:Antibiotics, Antineoplastic; D000964:Antimetabolites, Antineoplastic; D016685:Mitomycin; D005472:Fluorouracil