title: Ovarian dysgerminoma showing high serum levels and positive immunostaining of placental alkaline phosphatase and neuron-specific enolase associated with elevation of serum prolactin level.
abstract: We report a 35-year-old Japanese female patient with ovarian dysgerminoma showing elevated serum levels of placental alkaline phosphatase (PLAP), neuron-specific enolase (NSE) and prolactin (PRL). All elevated tumor markers improved dramatically after the removal of the tumor. Immunohistochemically examined, the tumor was stained positive for PLAP and NSE and negative for PRL. Our present case is the first report of dysgerminoma showing positive immunostaining for PLAP and NSE, and the association of high serum level of PRL followed by decrease accompanied by the tumor debulking.
authors.affiliation: Department of Obstetrics and Gynecology, Tenri Hospital, Nara, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
authors.forename: M
authors.initials: M
authors.lastname: Koshiyama
authors.forename: M
authors.initials: M
authors.lastname: Konishi
authors.forename: H
authors.initials: H
authors.lastname: Fujii
authors.forename: H
authors.initials: H
authors.lastname: Nanno
authors.forename: M
authors.initials: M
authors.lastname: Hayashi
authors.forename: K
authors.initials: K
authors.lastname: Kanehira
authors.forename: M
authors.initials: M
authors.lastname: Matsuki
authors.forename: K
authors.initials: K
authors.lastname: Tauchi
mesh_terms: D000328:Adult; D000469:Alkaline Phosphatase / Q000032:analysis / Q000097:blood*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor; D004407:Dysgerminoma / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D010751:Phosphopyruvate Hydratase / Q000032:analysis / Q000097:blood*; D010920:Placenta / Q000201:enzymology*; D011388:Prolactin / Q000032:analysis / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D011388:Prolactin; D000469:Alkaline Phosphatase; D010751:Phosphopyruvate Hydratase