Influences of hydrogel contact lens care solutions on corneal epithelial wound healing.
We studied the influences of hydrogel contact lens care solutions on corneal epithelial wound healing in vitro. The corneal epithelial wounds, 1.5 mm in diameter, 70 microns in depth were created on the pig's eyeballs by the excimer laser. The hydrogen peroxide systems including AOSEPT, Oxysept, Contopharma-peroxide-system were neutralized first, then applied three times on the epithelial wounds. The neutralizing procedures included the agents, duration, doses and containers following the instructions accompanied in the package of the solutions. The multipurpose care solutions including Opti-free, Hexidin, Bausch & Lomb Sensitive Eyes were applied directly as well. The healing scores were ranked 24 hours later with the fluorescin stain. There were no statistical differences between the healing scores of each experiment group and control group performed with Mann-Whitney rank-sum test. None of the lens care solutions retarded the corneal epithelial wound healing when compared with the BSS. The contact lenses treated with above solutions may be safely applied on eye without rinsing.
Lin
C P
CP
Department of Ophthalmology, Kaohsiung Medical College, Taiwan, Republic of China.
Chen
J Y
JY
Boehnke
M
M
D000818:Animals; D018639:Contact Lens Solutions / Q000633:toxicity*; D003315:Cornea / Q000187:drug effects* / Q000502:physiology; D004848:Epithelium / Q000187:drug effects; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D006861:Hydrogen Peroxide / Q000633:toxicity; D013552:Swine; D014945:Wound Healing / Q000187:drug effects*
D018639:Contact Lens Solutions; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D006861:Hydrogen Peroxide