[Molecular bases of prion diseases].
The paper briefly analyzes the origin of priones and their association with the cellular gene and homologous protein of diseases in man and animals. There is evidence for a direct relationship of the agents that cause spongious encephalitis in the cattle and a new type of Creutzfeldt-Jacob disease in man. The molecular organization of priones and the conformational cellular protein changes underlying the infectious activation of the cell homologue of priones. Emphasis is first laid on the capacity of the cell homologue of priones and their infectiously active derivative to bind to DNA or RNA. In the context of concepts of the priones yeasts an attempt was made to explain the reproduction through the altered control of translation of mRNA that encodes the cellular homologue of priones, which accounts for the duration of the incubation period of the disease. The infections caused by priones are referred to as the so-called slow infections. But in the context of the proposed hypothesis, an infective process in the tissues did not really have some typical signs of infection and resembles accumulation diseases more without the replicative burst typical of infectious processes. The paper gives data on the vital cycle of priones in infected animals and changes in the accumulation of an infective agent. This assesses the currently available diagnostic methods and gives preference to the methods which will be based on the use of monoclonal antibodies that specifically recognize the conformationally altered form of an infectious prione or on the identification of primary oligomeric forms which manifest the onset of amyloidization of the damaged tissues. The main conclusion of the paper is that protein prionization is a common biological phenomenon and the diseases caused by these processes will increase in number in the near future, which makes it necessary to develop diagnostic methods and universal treatments of diseases, such as bacterial infections by using antibiotics.
Pokrovskiĭ
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VI
Kiselev
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OI
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001665:Binding Sites; D004247:DNA / Q000032:analysis*; D006801:Humans; D015394:Molecular Structure; D017096:Prion Diseases / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism; D011328:Prions / Q000737:chemistry / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis*
D000900:Anti-Bacterial Agents; D011328:Prions; D012333:RNA, Messenger; D004247:DNA
Molekuliarnye osnovy prionnykh bolezneĭ.