Three dimensional electron spin resonance (ESR) imaging of internal organs in living mice.
In vivo electron spin resonance imaging (ESR imaging) was applied to living mice after peroral administration of a nitroxide radical spin probe. A 3D ESR imaging procedure was applied in vivo in order to obtain the exact distribution of the spin probe in a living animal. The imaging pictures demonstrated that the administered spin probe was firstly located in the stomach, then delivered to the liver, kidney and heart of the animal.
Masumizu
T
T
ESR Application Laboratory, Application & Research Center, Analytical Instruments Division, JEOL LTD., Tokyo, Japan.
Fujii
K
K
Kohno
M
M
Nagai
S
S
Odagaki
Y
Y
Imanari
M
M
Mori
A
A
Packer
L
L
D000818:Animals; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods*; D005260:Female; D051379:Mice; D009589:Nitrogen Oxides / Q000493:pharmacokinetics; D013113:Spin Labels; D014018:Tissue Distribution
D009589:Nitrogen Oxides; D013113:Spin Labels; C039900:nitroxyl