Fully mobilizing host defense: building better vaccines.
Developments in methods for identifying antigens from infectious agents and cancers has provided exciting new opportunities in prevention and treatment through vaccination. In many of these situations, however, traditional immunization techniques do not stimulate protective immunity because they fail to fully mobilize the appropriate immune responses. This limitation, together with new insights into the underlying mechanism of immune responses, has spurred development of several new approaches for vaccine delivery. We discuss some of the current efforts being developed to provide effective vaccine delivery systems.
Raychaudhuri
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Corixa Corporation, Seattle, WA 98104, USA.
Rock
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KL
D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000818:Animals; D017951:Antigen Presentation; D000941:Antigens / Q000008:administration & dosage; D001402:B-Lymphocytes / Q000276:immunology; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology; D001709:Biotechnology; D003713:Dendritic Cells / Q000276:immunology; D016503:Drug Delivery Systems; D015395:Histocompatibility Antigens Class I / Q000008:administration & dosage; D006801:Humans; D008264:Macrophages / Q000276:immunology; D008863:Microspheres; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014612:Vaccines / Q000008:administration & dosage* / Q000276:immunology; D019444:Vaccines, DNA / Q000008:administration & dosage / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology
D000276:Adjuvants, Immunologic; D000941:Antigens; D001428:Bacterial Vaccines; D015395:Histocompatibility Antigens Class I; D014612:Vaccines; D019444:Vaccines, DNA; D014765:Viral Vaccines