title: Ephrin-A1 is expressed at sites of vascular development in the mouse.
abstract: B61 (ephrin-A1), a ligand for eph receptor-protein tyrosine kinases, possesses angiogenic and endothelial cell chemoattractant activity. We report the expression profile of ephrin-A1 during mouse embryogenesis (7.25 to 10.5 days post-coitum (dpc)). Ephrin-A1 expression was first detected in the caudal end of the primitive streak and the developing allantois. At mid head fold stage, ephrin-A1 transcripts were observed in the anterior pharyngeal endoderm that underlies the site of the future heart. In 8.0 to 8.5 dpc embryos, ephrin-A1 was expressed in presumptive endocardial cells, the dorsal aorta, and the primary head veins. In 9.5 to 10.5 dpc embryos, ephrin-A1 RNA was detected in intersomitic vessels and the limb bud vasculature. Each site of ephrin-A1 expression corresponded to regions of vasculogenesis and/or angiogenesis.
authors.affiliation: Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.
authors.forename: J L
authors.initials: JL
authors.lastname: McBride
authors.forename: J C
authors.initials: JC
authors.lastname: Ruiz
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000196:embryology; D004627:Embryonic Induction / Q000235:genetics; D004730:Endothelium, Vascular / Q000196:embryology*; D036382:Ephrin-A1; D018507:Gene Expression Regulation, Developmental; D006257:Head / Q000098:blood supply / Q000196:embryology; D018878:Limb Buds / Q000378:metabolism; D008648:Mesoderm; D051379:Mice; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D019170:Somites / Q000378:metabolism
chemical_list: D036382:Ephrin-A1; D011506:Proteins