Multi-anode detection in electrospray ionization time-of-flight mass spectrometry.
An electrospray ionization ion source coupled to a time-of-flight mass analyzer incorporating a multi-anode time-to-digital converter is described. High-speed data acquisition (kHz mass spectral acquisition) rates are achieved. The four-anode detector produces a significant increase in detection/counting efficiency over that for a single-anode detector. In this work a 2.5 times increase in detection efficiency is demonstrated. The multi-anode detector is also used as a diagnostic tool to optimize transmission of the ion optics.
Barbacci
D C
DC
Department of Chemistry, Texas A&M University, College Station 77843, USA.
Russell
D H
DH
Schultz
J A
JA
Holocek
J
J
Ulrich
S
S
Burton
W
W
Van Stipdonk
M
M
D003574:Cytochrome c Group / Q000737:chemistry; D003626:Data Display; D003627:Data Interpretation, Statistical; D004566:Electrodes; D006801:Humans; D013058:Mass Spectrometry / Q000295:instrumentation / Q000379:methods*
D003574:Cytochrome c Group