Enhancement of diltiazem bioavailability by traces of surfactants in rats after neomycin-induced malabsorption syndrome.
Bioavailability of diltiazem was investigated in rats with the neomycin induced malabsorption syndrome in presence of surfactants. Tween 80, sodium lauroyl sulphate and lecithin were added under their critical miscellar concentration levels. Increases of diltiazem bioavailability (in the range of 5-29%) promoted by additions of the surfactants were observed.
Wojdak
H
H
Department of Applied Pharmacy and Drug Design Technology, Medical Academy of Silesia, Sosnowiec, Poland.
D000818:Animals; D001682:Biological Availability; D002121:Calcium Channel Blockers / Q000493:pharmacokinetics*; D004110:Diltiazem / Q000493:pharmacokinetics*; D008286:Malabsorption Syndromes / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D009355:Neomycin / Q000633:toxicity; D011500:Protein Synthesis Inhibitors / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D013268:Stimulation, Chemical; D013501:Surface-Active Agents / Q000494:pharmacology*
D002121:Calcium Channel Blockers; D011500:Protein Synthesis Inhibitors; D013501:Surface-Active Agents; D004110:Diltiazem; D009355:Neomycin