title: Application of lipids and plasmid design for gene delivery to mammalian cells.
abstract: Cationic lipids are widely used for in vitro gene transfer due to their efficiency. The major challenges for the improvement of in vivo cationic lipid-mediated gene delivery reside in the design of more biocompatible lipoplexes mimicking viral-mediated gene delivery and in understanding the fate of the lipoplexes within the cells.
authors.affiliation: UMR 133 CNRS/Rhône-Poulenc Rorer, Vitry-sur-Seine, France.
authors.forename: D
authors.initials: D
authors.lastname: Scherman
authors.forename: M
authors.initials: M
authors.lastname: Bessodes
authors.forename: B
authors.initials: B
authors.lastname: Cameron
authors.forename: J
authors.initials: J
authors.lastname: Herscovici
authors.forename: H
authors.initials: H
authors.lastname: Hofland
authors.forename: B
authors.initials: B
authors.lastname: Pitard
authors.forename: F
authors.initials: F
authors.lastname: Soubrier
authors.forename: P
authors.initials: P
authors.lastname: Wils
authors.forename: J
authors.initials: J
authors.lastname: Crouzet
mesh_terms: D000818:Animals; D001709:Biotechnology; D002412:Cations; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D015195:Drug Design; D018014:Gene Transfer Techniques; D005822:Genetic Vectors; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D010957:Plasmids / Q000235:genetics*
chemical_list: D002412:Cations; D008055:Lipids