Experimental design approach for the optimization of supercritical fluid extraction of chlorophenols from polluted soils.
Supercritical fluid extraction and liquid chromatography-electrochemical detection (LC-ECD) were used to the determination of chlorophenols in contaminated soil samples. Full factorial design experiments were used in order to optimize the extraction parameters: pressure, extraction cell temperature and percentage of modifier. Pressure and percentage of modifier (methanol) had statistically significant effects on the recovery of the chlorophenols. Good repeatability (4.9-11.8%) and reproducibility (4.9-12.5%) were achieved and low detection limits (3-150 ng g-1) were obtained. The method was validated by comparing the results with those obtained in a European intercomparison exercise.
Santos
F J
FJ
Departament de Química Analítica, Universitat de Barcelona, Spain.
Jáuregui
O
O
Pinto
F J
FJ
Galceran
M T
MT
D002733:Chlorophenols / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D000432:Methanol; D008832:Microchemistry; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012987:Soil / Q000032:analysis*; D012989:Soil Pollutants / Q000032:analysis*
D002733:Chlorophenols; D012987:Soil; D012989:Soil Pollutants; D000432:Methanol