Androgens and fetal growth.
Boys are heavier than girls at term birth. Children with a 46,XY karyotype and androgen insensitivity syndrome (clinically complete form and/or proven mutations in the androgen receptor gene) were found to have a birth weight comparable to that of girls. These findings support the hypothesis that the difference in birth weight between boys and girls is generated by androgen action.
de Zegher
F
F
University of Leuven, Belgium.
Francois
I
I
Boehmer
A L
AL
Saggese
G
G
Müller
J
J
Hiort
O
O
Sultan
C
C
Clayton
P
P
Brauner
R
R
Cacciari
E
E
Ibáñez
L
L
Van Vliet
G
G
Tiulpakov
A
A
Saka
N
N
Ritzén
M
M
Sippell
W G
WG
D013734:Androgen-Insensitivity Syndrome / Q000235:genetics / Q000503:physiopathology*; D000728:Androgens / Q000502:physiology*; D001724:Birth Weight; D005314:Embryonic and Fetal Development; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009154:Mutation; D011944:Receptors, Androgen / Q000235:genetics; D012727:Sex Characteristics
D000728:Androgens; D011944:Receptors, Androgen