Renal and hepatic interactions of acetaminophen and amikacin in the infant rat.
Results suggest that amikacin at the highest dose induces more changes on the renal function while the effect of APAP is more marked on the hepatic function. It might suggest that simultaneous administration of amikacin-APAP produces less changes that when the drugs are administered alone.
Meléndez Camargo
M E
ME
Department of Pharmacy, Escuela Nacional de Ciencias Biológicas, México, D.F., México.p6
Lozano Cortés
M
M
D000082:Acetaminophen / Q000494:pharmacology*; D000410:Alanine Transaminase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000583:Amikacin / Q000494:pharmacology*; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001663:Bilirubin / Q000378:metabolism; D003404:Creatinine / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D005947:Glucose / Q000378:metabolism; D007668:Kidney / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D011188:Potassium / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000378:metabolism; D010130:p-Aminohippuric Acid / Q000378:metabolism
D018712:Analgesics, Non-Narcotic; D000900:Anti-Bacterial Agents; D011506:Proteins; D000082:Acetaminophen; D000583:Amikacin; D012964:Sodium; D003404:Creatinine; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D005947:Glucose; D001663:Bilirubin; D011188:Potassium; D010130:p-Aminohippuric Acid