title: Histologic findings in polyacrylamide-coated polytetrafluoroethylene (PTFE) arterial grafts in the rat abdominal aorta.
abstract: To improve cell attachment without inducing thrombogenesis, the authors coated the inner surface of polytetrafluoroethylene (PTFE) prostheses (I.D.: 1 mm; length: 10 mm; wall thickness: 0.5 mm; fibril length: 30 microm) with polyacrylamide (PAA), known to have a strong antithrombotic effect (PAA-PTFE). They implanted the prostheses into the abdominal aorta of rats, and retrieved them at intervals of up to 9 months. Graft healing was observed under light and scanning electron microscopy. All the inner surfaces of the grafts examined were barely covered with fibrin or platelets. The PAA-coated fibers had many projections, in contrast to the original PTFE prostheses. Neo-endothelium was observed to be directly attached to these structural fibers of the PAA-PTFE grafts. Restoration of the neointima was also observed in these vascular prostheses.
authors.affiliation: Department of Orthopedic Surgery, Nara Medical University, Kashihara City, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Maeda
authors.forename: A
authors.initials: A
authors.lastname: Fukui
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: Y
authors.initials: Y
authors.lastname: Inada
authors.forename: S
authors.initials: S
authors.lastname: Tamai
authors.forename: S
authors.initials: S
authors.lastname: Haga
authors.forename: K
authors.initials: K
authors.lastname: Tatsumi
authors.forename: H
authors.initials: H
authors.lastname: Yamamoto
authors.forename: S
authors.initials: S
authors.lastname: Ogata
authors.forename: H
authors.initials: H
authors.lastname: Iwata
authors.forename: Y
authors.initials: Y
authors.lastname: Ikada
mesh_terms: D000180:Acrylic Resins; D000818:Animals; D001012:Aorta, Abdominal / Q000601:surgery / Q000648:ultrastructure*; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation; D020099:Coated Materials, Biocompatible; D008297:Male; D008855:Microscopy, Electron, Scanning; D011138:Polytetrafluoroethylene; D051381:Rats; D011916:Rats, Inbred F344; D013997:Time Factors; D000099166:Polyacrylamides
chemical_list: D000180:Acrylic Resins; D020099:Coated Materials, Biocompatible; D011138:Polytetrafluoroethylene; D000099166:Polyacrylamides