title: L-proline as a nitrogen source increases the susceptibility of Saccharomyces cerevisiae S288c to fluconazole.
abstract: Fluconazole inhibition of Saccharomyces cerevisiae S288c growth was evaluated in media containing ammonia, L-proline or L-leucine as a nitrogen source. Growth inhibition by fluconazole was maximum when L-proline was used as a nitrogen source, while rhodamine 6G accumulation and fluconazole resistance were the highest when ammonia was the sole nitrogen source.
authors.affiliation: Biochemistry Department, School of Medicine, Buenos Aires University, Argentina.
authors.forename: C A
authors.initials: CA
authors.lastname: Stella
authors.forename: R
authors.initials: R
authors.lastname: Costanzo
authors.forename: H I
authors.initials: HI
authors.lastname: Burgos
authors.forename: D A
authors.initials: DA
authors.lastname: Saenz
authors.forename: R D
authors.initials: RD
authors.lastname: Venerus
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D003470:Culture Media; D004352:Drug Resistance, Microbial; D015725:Fluconazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009584:Nitrogen / Q000378:metabolism*; D011392:Proline / Q000378:metabolism*; D012235:Rhodamines / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000254:growth & development
chemical_list: D000935:Antifungal Agents; D003470:Culture Media; D012235:Rhodamines; D015725:Fluconazole; D011392:Proline; D009584:Nitrogen