Comparative efficacy of a single daily dose of two capsules Cyclo 3 Fort in the morning versus a repeated dose of one capsule morning and noon. A one-month study.
BACKGROUND
The efficacy of Cyclo 3 Fort has previously been demonstrated in placebo-controlled trials on plethysmographic and clinical parameters. Its objective was to demonstrate that after one month of therapy, the efficacy and safety of a single dose of two capsules of Cyclo 3 Fort in the morning were comparable to that of a twice daily dose of Cyclo 3 Fort, one capsule morning and noon.


METHODS
This single-center, randomised, double-blind study was conducted on 37 women with chronic lower-limb venous insufficiency, associating clinical or functional signs and abnormal plethysmographic values. Clinical parameters measured were those conventionally used to assess superficial venous insufficiency; the main laboratory parameter evaluated by plethysmography was the index of venous distensibility.


RESULTS
The results data show that in each of the study groups, all of the patients attained a significant improvement in their clinical conditions, confirmed by laboratory tests, following one month of therapy with Cyclo 3 Fort. On the other hand, comparison of results data between the two groups did not objectify any significant difference between the two treatment modalities.


CONCLUSIONS
Thus a single dose of two capsules of Cyclo 3 Fort in the morning appears as effective and as well-tolerated as a twice daily dose of one capsule of Cyclo 3 Fort morning and noon.
Boccalon
H
H
Service d'Angiologie, CHU Rangueil, Toulouse, France.
Causse
C
C
Yubero
L
L
D000284:Administration, Oral; D000328:Adult; D002214:Capsules; D002908:Chronic Disease; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007866:Leg / Q000098:blood supply*; D008875:Middle Aged; D010936:Plant Extracts / Q000008:administration & dosage*; D010991:Plethysmography; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage*; D014689:Venous Insufficiency / Q000188:drug therapy* / Q000503:physiopathology; D014690:Venous Pressure
D002214:Capsules; D010936:Plant Extracts; D014665:Vasodilator Agents; C013343:cyclo 3