Response to high doses of citalopram in treatment-resistant obsessive-compulsive disorder.
We report a severe case of obsessive-compulsive disorder (OCD) that responded to very high doses of citalopram (160 mg/day) after a poor response to clomipramine 250 mg/day for several years, alone or in combination with buspirone 30 mg/day or flupenthixol 4 mg/day. The patient had previously been submitted for capsulotomy which was declined, probably due to the magical content of her obsessions, which resembled delusions.
Bejerot
S
S
Department of Neuroscience, Psychiatry, University Hospital, Uppsala, Sweden.
Bodlund
O
O
D000328:Adult; D014151:Anti-Anxiety Agents / Q000494:pharmacology / Q000627:therapeutic use; D018687:Antidepressive Agents, Second-Generation / Q000008:administration & dosage / Q000627:therapeutic use*; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000494:pharmacology / Q000627:therapeutic use; D002065:Buspirone / Q000494:pharmacology / Q000627:therapeutic use; D015283:Citalopram / Q000008:administration & dosage / Q000627:therapeutic use*; D002997:Clomipramine / Q000494:pharmacology / Q000627:therapeutic use; D003702:Delusions / Q000188:drug therapy; D004351:Drug Resistance; D005260:Female; D005475:Flupenthixol / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000628:therapy*; D012008:Recurrence; D016896:Treatment Outcome
D014151:Anti-Anxiety Agents; D018687:Antidepressive Agents, Second-Generation; D000929:Antidepressive Agents, Tricyclic; D014150:Antipsychotic Agents; D015283:Citalopram; D005475:Flupenthixol; D002997:Clomipramine; D002065:Buspirone