title: Activity-controlled circadian base rate.
abstract: The current pacing rates are clustered around a fixed base rate since pacemaker patients are usually sedentary, resting, or sleeping most of the time. This fixed base rate is either too low for daytime hemodynamic support or too high for nighttime rest and recovery. Multiple Holter studies involving normal individuals have suggested that the resting base rate fluctuates during the course of the day. The circadian base rate (CBR) algorithm was designed to provide patients with a circadian change in paced resting rate and a normal rate distribution. The CBR algorithm, using a sophisticated accelerometer sensor, was developed and tested using the downloaded activity data from patients implanted with Trilogy DR+ pacemakers. Twenty-five patients (19 men, 6 women, age 72 +/- 9 years) were studied. Trilogy DR+ is able to record the detailed sensor and system behavior data for a week. During outpatient visits, the pacemaker was interrogated and the data accumulated in the pacemaker memory were downloaded. The CBR algorithm was applied to the activity variance histogram to calculate the base rate and to construct its histogram. The base rates in the CBR histogram are generally below 100 ppm with a distribution that mimics the natural sinus rate distribution of normal subjects. The CBR algorithm provides the highest daytime rates for hemodynamic support and the lowest nighttime rates for cardiac recovery, with a smoothly changing base rate modeling the normal circadian variation in heart rate.
authors.affiliation: A St. Jude Medical Company, Cardiac Rhythm Management Division, Sylmar, California, USA. epark@pcnet.pacesetter.com
authors.forename: E
authors.initials: E
authors.lastname: Park
authors.forename: D
authors.initials: D
authors.lastname: Weilenmann
authors.forename: K
authors.initials: K
authors.lastname: Bloch
authors.forename: J
authors.initials: J
authors.lastname: Kueffner
authors.forename: G
authors.initials: G
authors.lastname: Bornzin
authors.forename: R
authors.initials: R
authors.lastname: Candinas
authors.forename: P A
authors.initials: PA
authors.lastname: Levine
mesh_terms: D000368:Aged; D000465:Algorithms; D002304:Cardiac Pacing, Artificial / Q000379:methods*; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D010138:Pacemaker, Artificial