title: Alveolar-interstitial pneumopathy after gold-salts compounds administration, requiring mechanical ventilation.
abstract: The pulmonary toxicity of gold salts is an uncommon cause of life-threatening respiratory failure. Currently, patients who suffer from this do not need mechanical ventilation, and the toxicity can be difficult to diagnose when it occurs in patient with an illness producing pulmonary manifestations. We report a case of severe respiratory failure due to gold salt toxicity in a patient suffering from rheumatoid arthritis requiring mechanical ventilation. At such a time, the poor respiratory function makes some diagnostic procedures harmful. The diagnosis can be made after the exclusion of other causes of rheumatoid lung when the patient's poor respiratory status precludes invasive exploration. The clinical findings, radiological features, and results of pulmonary function tests may be enough to diagnose gold-related pneumopathy. This avoids the need for bronchoscopic examination or transfer of the patient for computed tomography. Attention must be paid to this complication because the outcome and functional prognosis are better when pulmonary involvement is gold related: in our case steroid therapy was life-saving and induced complete recovery of the lung damage.
authors.affiliation: Unidad de Cuidados Intensivos, Clínica Moncloa, Madrid, Spain. diegovb28@smail.ocefss.ucm.es
authors.forename: R
authors.initials: R
authors.lastname: Blancas
authors.forename: J L
authors.initials: JL
authors.lastname: Moreno
authors.forename: F
authors.initials: F
authors.lastname: Martín
authors.forename: R
authors.initials: R
authors.lastname: de la Casa
authors.forename: J J
authors.initials: JJ
authors.lastname: Oñoro
authors.forename: V
authors.initials: V
authors.lastname: Gómez
authors.forename: J
authors.initials: J
authors.lastname: Prados
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001989:Bronchiolitis Obliterans / Q000139:chemically induced; D003937:Diagnosis, Differential; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000628:therapy; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D050607:Organogold Compounds; D011175:Positive-Pressure Respiration; D011379:Prognosis; D011859:Radiography
chemical_list: D000893:Anti-Inflammatory Agents; D018501:Antirheumatic Agents; D050607:Organogold Compounds; D008775:Methylprednisolone