Inhibition of adrenaline-induced lipolysis by ginseng polypeptide and its modified peptides.
The anti-lipolysis by ginseng polypeptide and its modified peptides was examined using porcine adipose cells. Ginseng polypeptides modified by amino acid substitution or proteolyzation reduced or lost the inhibiting activity of adrenalin-induced lipolysis. Correlation between the anti-lipolytic activity of ginseng polypeptide and its Mg(2+)- and ribose-binding activities is discussed.
Kajiwara
H
H
Department of Biotechnology, National Institute of Agrobiological Resources, Ibaraki, Japan. kajiwara@abr.affrc.go.jp
Aso
H
H
Okubo
A
A
Yamazaki
S
S
D000273:Adipose Tissue / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D004837:Epinephrine / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008066:Lipolysis / Q000187:drug effects*; D010940:Plant Proteins / Q000494:pharmacology*; D012266:Ribose / Q000378:metabolism; D013552:Swine
D000960:Hypolipidemic Agents; D010940:Plant Proteins; C104839:ginseng pentadecapeptide, Panax ginseng; D012266:Ribose; D004837:Epinephrine