Neuropeptide Y concentrations in experimental Leishmania major cutaneous leishmaniasis.
Neuropeptide Y (NPY) concentrations were investigated by radioimmunoassay and immunohistochemistry in a murine model of cutaneous leishmaniasis, using a susceptible (BALB/c) and a resistant (C57BL/6) mouse strain. The analyses were performed on the skin, secondary lymphoid organs and dorsal root ganglia (DRG) at 1, 3, 6 and 9 weeks postinfection. An overall reduction in the NPY concentrations in the studied organs was observed in both mouse strains; the reduction in the skin and draining lymph nodes was more evident and progressive in the susceptible strain. Using immunohistochemistry there seemed to be a reduction in NPY immunoreactivity in all inflamed tissues analysed compared to the controls. These observations might indicate a possible pathophysiological role for NPY in murine cutaneous leishmaniasis.
Ahmed
A A
AA
Department of Dermatology, Karolinska Hospital, Stockholm, Sweden.
Ahmed
M
M
Theodorsson
E
E
Nordlind
K
K
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005727:Ganglia, Spinal / Q000737:chemistry* / Q000469:parasitology*; D007891:Leishmania; D016773:Leishmaniasis, Cutaneous / Q000276:immunology / Q000378:metabolism*; D008198:Lymph Nodes / Q000737:chemistry / Q000469:parasitology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009478:Neuropeptide Y / Q000032:analysis*; D012867:Skin / Q000737:chemistry / Q000469:parasitology; D013045:Species Specificity; D013154:Spleen / Q000737:chemistry / Q000469:parasitology
D009478:Neuropeptide Y