The mechanism of ceftazidime degradation in aqueous solutions.
Degradation of ceftazidime in aqueous solutions was studied at 298 K in acidic, basic and neutral conditions. The subsequent stage of hydrolysis involved the hydrolysis of the group at C-3, opening of the beta-lactam ring, and epimerization at C-6 or C-7. The decomposition of ceftazidime and the formation and identification of product C (pyridine) was followed by HPLC.
Zajac
M
M
Department of Pharmaceutical Chemistry, K. Marcinkowski University of Medical Sciences, Poznań, Poland.
Siwek
J
J
Muszalska
I
I
D002442:Ceftazidime / Q000737:chemistry*; D002511:Cephalosporins / Q000737:chemistry*; D007202:Indicators and Reagents; D007700:Kinetics; D019999:Pharmaceutical Solutions / Q000032:analysis; D013056:Spectrophotometry, Ultraviolet
D002511:Cephalosporins; D007202:Indicators and Reagents; D019999:Pharmaceutical Solutions; D002442:Ceftazidime