title: T-cell interactions with extracellular matrix proteins in periodontal disease.
abstract: Lymphoid cell infiltration of periodontal tissues undergoing pathological destruction suggests a functional interdependence between connective tissue proteins such as collagen, fibronectin and elastin and mononuclear cells, mainly T lymphocytes. The aim of the study was to assess T lymphocyte proliferation after stimulation by mAb OKT3 and then costimulation by ECM (extracellular matrix) proteins, as well as T-cell adhesion to connective tissue proteins in patients with adult periodontitis, early-onset periodontitis, chronic gingivitis and experimental gingivitis. Controls included patients with clinically healthy periodontium. Statistical analysis of results showed a significantly decreased level of T lymphocyte proliferation in response to costimulating action of ECM proteins among patients with adult periodontitis as compared to the control group. Reactivity of T-cells was much higher in experimental gingivitis than in adult periodontitis, and significantly lower in chronic gingivitis than in controls. In addition, T-cell interaction with ECM proteins was abnormal in early-onset periodontitis patients, but was not statistically significant.
authors.affiliation: Department of Conservative Dentistry, Dental Institute, Medical University of Warsaw, Poland. Dentam1@WAW1.Comnet.PL
authors.forename: S M
authors.initials: SM
authors.lastname: Słotwińska
authors.forename: A
authors.initials: A
authors.lastname: Górski
authors.forename: M
authors.initials: M
authors.lastname: Wierzbicka
authors.forename: E
authors.initials: E
authors.lastname: Dybizbański
authors.forename: T
authors.initials: T
authors.lastname: Mrowiec
authors.forename: E
authors.initials: E
authors.lastname: Iwanicka-Frankowska
mesh_terms: D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000276:immunology; D002448:Cell Adhesion; D016326:Extracellular Matrix Proteins / Q000276:immunology*; D005260:Female; D005891:Gingivitis / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D008934:Mitogens / Q000494:pharmacology; D010518:Periodontitis / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D016326:Extracellular Matrix Proteins; D008934:Mitogens