title: HIV infection: how effective is drug combination treatment?
abstract: The rate of decline of plasma HIV RNA in patients treated with anti-retroviral drugs has been postulated to reflect the half-lives of previously HIV-infected cells. Here, Zvi Grossman and colleagues argue that the observed decline is explained by the kinetics of ongoing infection cycles. Residual cell-to-cell infection that becomes increasingly difficult to block could stabilize cellular provirus reservoirs.
authors.affiliation: NIH Office of AIDS Research, Bethesda, MD 20892, USA. wepaul@nih.gov
authors.forename: Z
authors.initials: Z
authors.lastname: Grossman
authors.forename: M
authors.initials: M
authors.lastname: Feinberg
authors.forename: V
authors.initials: V
authors.lastname: Kuznetsov
authors.forename: D
authors.initials: D
authors.lastname: Dimitrov
authors.forename: W
authors.initials: W
authors.lastname: Paul
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D015496:CD4-Positive T-Lymphocytes / Q000821:virology; D004359:Drug Therapy, Combination; D006678:HIV / Q000187:drug effects / Q000302:isolation & purification / Q000502:physiology; D015658:HIV Infections / Q000188:drug therapy* / Q000517:prevention & control / Q000821:virology; D006801:Humans; D008954:Models, Biological; D008962:Models, Theoretical; D012367:RNA, Viral / Q000097:blood; D019562:Viral Load; D014779:Virus Replication / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents; D012367:RNA, Viral