title: Solitary intraosseous infantile myofibroma of the orbital roof.
abstract: BACKGROUND
  There are several rare tumors that can cause proptosis in an infant, including infantile myofibroma.
  
  
  METHODS
  A 3-month-old infant developed a painless, bone-destructive superomedial orbital mass, raising concern for orbital malignant neoplasms. Computed tomography disclosed a bone-destructive mass of the sphenoid wing. On magnetic resonance imaging, the intraosseous mass was well-circumscribed, surrounded by cortical bone, and showed prominent enhancement.
  
  
  RESULTS
  Superomedial orbitotomy and biopsy revealed a lesion composed of spindled to stellate cells, without mitotic activity, set in a fibromyxoid stroma. Immunohistochemical stains were positive for vimentin and actin. Ultrastructurally, there were actinlike thin filaments, mitochondria, and rough endoplasmic reticulum confirming a myofibroblastic proliferation and supporting the diagnosis of congenital infantile myofibroma.
  
  
  CONCLUSIONS
  Infantile myofibroma is a benign tumor that occurs rarely in the ocular region but can cause prominent bone destruction, misleading the clinician to suspect a malignant neoplasm.
authors.affiliation: Oncology Service, Wills Eye Hospital, Thomas Jeferson University, Philadelphia, Pa., USA.
authors.forename: C L
authors.initials: CL
authors.lastname: Shields
authors.forename: M
authors.initials: M
authors.lastname: Husson
authors.forename: J A
authors.initials: JA
authors.lastname: Shields
authors.forename: G
authors.initials: G
authors.lastname: Mercado
authors.forename: R C
authors.initials: RC
authors.lastname: Eagle
mesh_terms: D005260:Female; D006801:Humans; D007223:Infant; D007889:Leiomyoma / Q000151:congenital / Q000000981:diagnostic imaging / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D009918:Orbital Neoplasms / Q000151:congenital / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed