[Resuming of thermoregulation in rats during deep hypothermia with EDTA without rewarming the body].
Administration of the EDTA, a substance binding calcium ions, helped to resume thermoregulation functions after their "cold paralysis" at the rectal temperature 17.1 +/- 0.2 degrees C and the brain temperature 19.2 +/- 0.2 degrees C, without warming up the animal. Enhancement of the muscle electrical activity following the EDTA administration was due both to increase in the number of bursts of shivering and to enhancement of their intensity. The findings suggest that, in hypothermia, improvement of conditions of the calcium ion transport from the cell cytosole into interstitial space helps to restoration of the cold muscle shivering as an important function of the thermoregulation.
Arokina
N K
NK
I. P. Pavlov Institute of Physiology of the Russian Acad. Sci, St. Petersburg, Russia.
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D002118:Calcium / Q000378:metabolism; D002614:Chelating Agents / Q000494:pharmacology*; D004492:Edetic Acid / Q000494:pharmacology*; D004576:Electromyography; D007035:Hypothermia / Q000503:physiopathology*; D007101:Immersion; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012768:Shivering / Q000187:drug effects
D002614:Chelating Agents; D004492:Edetic Acid; D002118:Calcium
Vozobnovlenie funktsiĭ termoreguliatsii u krys pri glubokoĭ gipotermii s pomoshch'iu EDTA bez otogrevaniia tela.