title: [Experimentally induced actin depolymerization disrupts the adaptive state of a neuron].
abstract: The state of filament actin in Mauthner neuron (MN) of gold-fish adapted to long-term natural stimulation was investigated after introduction of actin-depolymerizing cytochalasin D. Cytochalasin was demonstrated to cause almost complete disappearance of long actin bundles that were characteristic for the cytoplasm of adapted fish and were absent from MN of intact fish. Polymeric actin supporting the cytoskeleton integrity was suggested to be involved in mechanisms underlying the increase of MN resistance extreme loads.
authors.affiliation: Laboratory of Neuron Ultrastructure, Russian Academy of Sciences, Pushchino, Moscow District.
authors.forename: L L
authors.initials: LL
authors.lastname: Pavlik
authors.forename: N R
authors.initials: NR
authors.lastname: Tiras
authors.forename: D A
authors.initials: DA
authors.lastname: Moshkov
mesh_terms: D000199:Actins / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D000222:Adaptation, Physiological / Q000187:drug effects*; D000818:Animals; D015638:Cytochalasin D / Q000494:pharmacology; D004247:DNA / Q000096:biosynthesis; D006054:Goldfish; D009474:Neurons / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D019384:Nucleic Acid Synthesis Inhibitors / Q000494:pharmacology; D010812:Physical Stimulation / Q000379:methods; D011149:Pons / Q000187:drug effects / Q000502:physiology / Q000648:ultrastructure; D014722:Vestibule, Labyrinth / Q000502:physiology
chemical_list: D000199:Actins; D019384:Nucleic Acid Synthesis Inhibitors; D015638:Cytochalasin D; D004247:DNA
vernacular_title: Eksperimental'no vyzvannaia depolimerizatsiia aktina razrushaet adaptivnoe sostoianie neĭrona.