Cleavage planes in frog eggs are altered by strong magnetic fields.
Early cleavages of Xenopus embryos were oriented in strong, static magnetic fields. Third-cleavage planes, normally horizontal, were seen to orient to a vertical plane parallel with a vertical magnetic field. Second cleavages, normally vertical, could also be oriented by applying a horizontal magnetic field. We argue that these changes in cleavage-furrow geometries result from changes in the orientation of the mitotic apparatus. We hypothesize that the magnetic field acts directly on the microtubules of the mitotic apparatus. Considerations of the length of the astral microtubules, their diamagnetic anisotropy, and flexural rigidity predict the required field strength for an effect that agrees with the data. This observation provides a clear example of a static magnetic-field effect on a fundamental cellular process, cell division.
Denegre
J M
JM
Department of Molecular Biology, Cell Biology & Biochemistry, Brown University, Providence, RI 02912, USA.
Valles
J M
JM
Lin
K
K
Jordan
W B
WB
Mowry
K L
KL
D000818:Animals; D004625:Embryo, Nonmammalian / Q000166:cytology / Q000502:physiology / Q000528:radiation effects*; D008280:Magnetics; D008870:Microtubules / Q000528:radiation effects; D008938:Mitosis / Q000528:radiation effects; D014981:Xenopus / Q000196:embryology*