title: Pilot study of pathophysiology of constipation among community diabetics.
abstract: We aimed to compare gastrointestinal transit and defecatory function in a random sample of people with or without diabetes mellitus in a US community who reported constipation or laxative use. In this pilot study we measured: gastric, small bowel, and colonic transit by scintigraphy; vector manometry of anal sphincters at rest and during squeeze; defecatory dynamics by balloon expulsion test; and scintigraphic measurement of anorectal angle at rest and during defecation. Autonomic function tests were performed in diabetics. Diabetics with constipation had a higher prevalence of abnormal evacuation or prolonged colonic transit during the first 24 hr than controls (P = 0.07): three had prolonged 24-hr colonic transit, and three abnormal evacuation. Among constipated controls, only one had anismus. Overall, diabetics had slower colonic transit during the first 24 hr than nondiabetics (P < 0.05). Community diabetics who experience constipation or use laxatives have a greater prevalence of delayed 24-hr colonic transit or evacuatory dysfunction than community controls.
authors.affiliation: Gastroenterology Research Unit, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.
authors.forename: D
authors.initials: D
authors.lastname: Maleki
authors.forename: M
authors.initials: M
authors.lastname: Camilleri
authors.forename: D D
authors.initials: DD
authors.lastname: Burton
authors.forename: D M
authors.initials: DM
authors.lastname: Rath-Harvey
authors.forename: L
authors.initials: L
authors.lastname: Oenning
authors.forename: J H
authors.initials: JH
authors.lastname: Pemberton
authors.forename: P A
authors.initials: PA
authors.lastname: Low
mesh_terms: D000328:Adult; D000368:Aged; D001003:Anal Canal / Q000000981:diagnostic imaging / Q000503:physiopathology; D003248:Constipation / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*; D003672:Defecation; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D004043:Dietary Fiber / Q000008:administration & dosage; D005260:Female; D005772:Gastrointestinal Transit; D006801:Humans; D008297:Male; D008365:Manometry / Q000379:methods / Q000706:statistics & numerical data; D008875:Middle Aged; D010865:Pilot Projects; D011877:Radionuclide Imaging; D018709:Statistics, Nonparametric; D013667:Technetium; D013997:Time Factors
chemical_list: D004043:Dietary Fiber; D013667:Technetium