title: Performance of adhesive bone cement containing hydroxyapatite particles.
abstract: A new acrylic bone cement which can adhere to both bone and prostheses was developed based on a methyl methacrylate (MMA) monomer containing 4-methacryloyloxyethyl trimellitate anhydride (4-META) as adhesion promoting agent. Moreover, hydroxyapatite (HA) particles were introduced into the 4-META cement as a bone compatible filler. The mechanical strengths of an acrylic bone cement without 4-META decreased drastically with an increase in the percentage of HA particles in the cement. However, the mechanical strengths of the HA-containing 4-META cement did not change in the same way as that of the 4-META cement without HA due to adhesion between the cement HA particles and matrix. The HA particles did not affect the adhesion of the 4-META cement to bone and metals. Implantation of the 4-META cement and the HA-containing 4-META cement in animals demonstrated that these cements did not disturb bone ingrowth and the new bone was able to contact the cement directly. The 4-META cements, with and without HA particles, could adhere to bone in vivo.
authors.affiliation: Department of Orthopedic Surgery, Faculty of Medicine, Tokyo Medical and Dental University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Morita
authors.forename: K
authors.initials: K
authors.lastname: Furuya
authors.forename: K
authors.initials: K
authors.lastname: Ishihara
authors.forename: N
authors.initials: N
authors.lastname: Nakabayashi
mesh_terms: D001672:Biocompatible Materials; D001696:Biomechanical Phenomena; D001843:Bone Cements; D001842:Bone and Bones; D017886:Durapatite; D006801:Humans; D008689:Methacrylates; D016348:Osseointegration; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D001843:Bone Cements; D008689:Methacrylates; C034139:4-methacryloxyethyltrimellitic acid anhydride; D017886:Durapatite