title: Relationship between doubling time of liver metastases from colorectal carcinoma and residual primary cancer.
abstract: BACKGROUND
  The doubling times of liver metastases were calculated in order to clarify their usefulness in predicting the presence of residual cancer in the abdominal cavity in patients who had undergone curative resection of primary colorectal cancer.
  
  
  METHODS
  Tumor doubling times were calculated retrospectively in 22 patients by serial measurement of the size of their liver metastases.
  
  
  RESULTS
  Patients with a tumor doubling time of less than 92.4 days had a significantly poorer prognosis than those with a doubling time more than or equal to 92.4 days (p < 0.05). Local recurrence or peritoneal dissemination was significantly more likely to occur when the tumor doubling time was less than 92.4 days than when it was more than or equal to 92.4 days (p < 0.01).
  
  
  CONCLUSIONS
  The doubling time of hepatic metastases in patients with colorectal carcinoma may be a useful prognostic indicator, with patients who have a shorter tumor doubling time carrying a greater risk of residual primary cancer in the abdominal cavity.
authors.affiliation: First Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nomura
authors.forename: S
authors.initials: S
authors.lastname: Miyagawa
authors.forename: H
authors.initials: H
authors.lastname: Harada
authors.forename: H
authors.initials: H
authors.lastname: Kitamura
authors.forename: H
authors.initials: H
authors.lastname: Seki
authors.forename: R
authors.initials: R
authors.lastname: Shimada
authors.forename: A
authors.initials: A
authors.lastname: Kobayashi
authors.forename: T
authors.initials: T
authors.lastname: Noike
authors.forename: S
authors.initials: S
authors.lastname: Kawasaki
mesh_terms: D002455:Cell Division; D015179:Colorectal Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology* / Q000556:secondary / Q000601:surgery; D008297:Male; D008875:Middle Aged; D018365:Neoplasm, Residual; D010534:Peritoneal Neoplasms / Q000556:secondary; D012189:Retrospective Studies; D013997:Time Factors