Pattern of red blood cells and platelets cholesterol and fatty acids in homozygous familial hypercholesterolemic patients treated with LDL-apheresis.
Two homozygous familial hypercholesterolemic patients were treated with dextran-sulfate cellulose LDL-apheresis (DSC-LDL/A). We evaluated qualitatively and quantitatively, red cell and platelets membrane cholesterol and fatty acids, before and after LDL-apheresis. Fatty acids and cholesterol of red blood cells and platelets were determined by gas-chromatographic technique. We failed to observe any quantitative or qualitative modification, as far as the youngest patient (MD) is concerned. Only in the oldest patient (SM), docosaesanoic acid (22:6) values, were significantly reduced by LDL-A on quantitative basis. In the same patient, also mirystic acid (14:0) values, were significantly decreased as determined by qualitative method. The above mentioned fatty acids were significantly changed in platelets on treatment with LDL-apheresis performed on weekly basis.
Stefanutti
C
C
Istituto di Terapia Medica Sistematica, Sezione di Plasmaferesi, Università La Sapienza, Rome, Italy.
Lucani
G
G
Vivenzio
A
A
Di Giacomo
S
S
Lucani
E
E
Mazzarella
B
B
D000328:Adult; D001792:Blood Platelets / Q000737:chemistry*; D002648:Child; D002784:Cholesterol / Q000097:blood*; D002849:Chromatography, Gas; D004912:Erythrocytes / Q000737:chemistry*; D005227:Fatty Acids / Q000097:blood*; D006720:Homozygote; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood* / Q000628:therapy; D008077:Lipoproteins, LDL / Q000302:isolation & purification*; D008297:Male; D010956:Plasmapheresis / Q000379:methods*
D005227:Fatty Acids; D008077:Lipoproteins, LDL; D002784:Cholesterol