Adhesion and signaling mediated by the cytoplasmic tails of leucocyte integrins.
Integrins not only mediate cell adhesion but also contribute to a variety of other cellular processes including proliferation, cytokine production, cytotoxicity and apoptosis. They act as bi-directional signal transducers, mediating signaling from inside-to-outside the cell and from outside-to-inside the cell. Evidence is emerging that signaling through leukocyte integrins (beta 2 and beta 7) is distinct from signaling by the more widely distributed beta 1 integrins. Here we discuss the role of the cytoplasmic domains of leukocyte integrins and that of cytosolic proteins that bind integrins in mediating signal transduction. Distinct sites in the alpha as well as the common beta chain contribute to this process. We also show that beta 2 integrin distribution on the cell surface is of particular relevance for leukocytes to rapidly alter their adhesive state and display their highly dynamic adhesive behavior. From these and recently published findings the picture is arising that particular cell functions may be supported by integrin-specific signaling pathways.
van Kooyk
Y
Y
Department of Tumor Immunology, University of Nijmegen, The Netherlands.
Lub
M
M
Figdor
C G
CG
D000595:Amino Acid Sequence; D000818:Animals; D002448:Cell Adhesion / Q000276:immunology; D003593:Cytoplasm / Q000737:chemistry*; D006801:Humans; D016023:Integrins / Q000235:genetics / Q000276:immunology*; D007962:Leukocytes / Q000737:chemistry* / Q000166:cytology / Q000276:immunology; D008969:Molecular Sequence Data; D015398:Signal Transduction / Q000276:immunology*
D016023:Integrins