title: Susceptibility of penicillin-susceptible and -resistant pneumococci to CFC-222, a new fluoroquinolone.
abstract: The in-vitro activity of 12 antibacterial agents against 98 clinical isolates of Streptococcus pneumoniae, including 54 penicillin-resistant strains, was determined by a standardized broth microdilution method. CFC-222, vancomycin and imipenem were the most active agents, with an MIC90 of 0.5 mg/L for the test strains. CFC-222 was 16-fold more potent than ciprofloxacin and ofloxacin against all strains tested, including both penicillin-susceptible and -resistant strains. The anti-pneumococcal activity of fluoroquinolones was not affected by penicillin susceptibility. These results indicate that CFC-222 is potentially useful for treating infection caused by penicillin-resistant strains of S. pneumoniae.
authors.affiliation: Department of Microbial Chemistry, College of Pharmacy, Seoul National University, South Korea.
authors.forename: J H
authors.initials: JH
authors.lastname: Kim
authors.forename: J A
authors.initials: JA
authors.lastname: Kang
authors.forename: Y
authors.initials: Y
authors.lastname: Lee
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
authors.forename: J H
authors.initials: JH
authors.lastname: Lee
authors.forename: E C
authors.initials: EC
authors.lastname: Choi
authors.forename: B K
authors.initials: BK
authors.lastname: Kim
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D024841:Fluoroquinolones; D006801:Humans; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology*; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000890:Anti-Infective Agents; C097672:CFC 222; D024841:Fluoroquinolones; D010406:Penicillins