title: Cerebrospinal fluid levels of alpha-tocopherol in amyotrophic lateral sclerosis.
abstract: We compared CSF and serum levels, and the CSF/serum ratio of alpha-tocopherol (vitamin E), measured by HPLC, in 30 patients with sporadic amyotrophic lateral sclerosis (SALS) and 78 matched controls. The mean CSF and serum vitamin E levels did not differ significantly between the 2 study groups. These values were not influenced by the clinical form (spinal versus bulbar) of SALS. CSF alpha-tocopherol levels did not correlate with age, age at onset, and duration of the disease. These results suggest that CSF and serum alpha-tocopherol concentrations are unrelated with the risk for ALS.
authors.affiliation: Department of Biochemistry, Hospital Universitario Doce de Octubre, Madrid, Spain.
authors.forename: F
authors.initials: F
authors.lastname: de Bustos
authors.forename: F J
authors.initials: FJ
authors.lastname: Jiménez-Jiménez
authors.forename: J A
authors.initials: JA
authors.lastname: Molina
authors.forename: J
authors.initials: J
authors.lastname: Esteban
authors.forename: A
authors.initials: A
authors.lastname: Guerrero-Sola
authors.forename: M
authors.initials: M
authors.lastname: Zurdo
authors.forename: M
authors.initials: M
authors.lastname: Ortí-Pareja
authors.forename: A
authors.initials: A
authors.lastname: Tallón-Barranco
authors.forename: C
authors.initials: C
authors.lastname: Gómez-Escalonilla
authors.forename: C
authors.initials: C
authors.lastname: Ramírez-Ramos
authors.forename: J
authors.initials: J
authors.lastname: Arenas
authors.forename: R
authors.initials: R
authors.lastname: Enríquez de Salamanca
mesh_terms: D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D008161:Lumbosacral Region; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D014810:Vitamin E / Q000097:blood / Q000134:cerebrospinal fluid*
chemical_list: D014810:Vitamin E