title: Possible role of plasma neurotensin on growth hormone regulation in neonates.
abstract: OBJECTIVE
  To evaluate secretion of plasma neurotensin (NT) which could be involved as a peripheral signal in growth hormone (GH) regulation, NT release was measured during early postnatal life, a period of striking changes in GH secretion.
  
  
  METHODS
  Blood samples were collected from 19 normal full-term neonates on day 5 and at 3 months of age to evaluate plasma NT concentrations by radioimmunoassay, serum growth hormone (GH) levels using an immunofluorometric assay, and serum insulin-like growth factor-I (IGF-I) values by radioimmunoassay.
  
  
  RESULTS
  Five day-old neonates showed significantly higher (p < 0.001) mean (+/- SEM) plasma NT levels (83.55 +/- 12.07 fmol/ml) compared with those in 11 prepubertal children and those in 14 adults who were studied as control subjects (13.30 +/- 2.90 and 9.70 +/- 1.10 fmol/ml, respectively). In 5 day-old neonates we observed significantly higher (p < 0.001) serum GH levels (29.53 +/- 3.40 ng/ml) compared with those in the prepubertal children (1.26 +/- 0.28 ng/ml). Five day-old neonates showed significantly lower (p < 0.001) serum IGF-I concentrations (27.01 +/- 0.77 ng/ml) than those in the prepubertal children (210 +/- 25 ng/ml). At 3 months of age, plasma NT levels (59.37 +/- 7.47 fmol/ml) and serum GH values (4.40 +/- 0.60 ng/ml) were significantly decreased (p < 0.001). At the 3rd month of life, serum IGF-I levels (44.88 +/- 4.30 ng/ml) were increased significantly (p < 0.001).
  
  
  CONCLUSIONS
  The human neonate showed very high concentrations of NT and GH in comparison with those observed in control subjects. The postnatal rise in IGF-I values is presumed to determine the fall in serum GH concentrations by stimulating somatostatin secretion. Neurotensin could be involved as a peripheral signal in the inhibitory mechanisms mediated by release of somatostatin.
authors.affiliation: Department of Pediatrics, University of Pavia, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Bozzola
authors.forename: A
authors.initials: A
authors.lastname: Ntodou-Thome
authors.forename: G
authors.initials: G
authors.lastname: Bona
authors.forename: M
authors.initials: M
authors.lastname: Autelli
authors.forename: M L
authors.initials: ML
authors.lastname: Magnani
authors.forename: G
authors.initials: G
authors.lastname: Radetti
authors.forename: R M
authors.initials: RM
authors.lastname: Schimpff
mesh_terms: D000328:Adult; D000375:Aging; D015200:Fluoroimmunoassay; D006706:Homeostasis; D019382:Human Growth Hormone / Q000097:blood*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D009496:Neurotensin / Q000097:blood*; D011863:Radioimmunoassay; D012016:Reference Values
chemical_list: D019382:Human Growth Hormone; D009496:Neurotensin; D007334:Insulin-Like Growth Factor I