title: Oesophageal motility and gastro-oesophageal reflux: effect of variceal eradication by endoscopic sclerotherapy.
abstract: Endoscopic injection sclerotherapy (EIS) is known to produce oesophageal structural and motility changes; however, alterations in frequency and severity of gastro-oesophageal reflux (GER) following EIS have not been investigated in detail. We studied 22 patients with cirrhosis and oesophageal varices before EIS and 26 after variceal eradication with intravariceal EIS using manometry and 24 h pH monitoring. The post-EIS group had reduced oesophageal sphincter pressure (19.2+/-11.4 vs 26.1 +/-16.4 mmHg, P< 0.05) and slower velocity of oesophageal peristalsis (2.47+/-0.71 vs 3.06+/-0.77 cm/s, P< 0.01) than the pre-EIS patients. There was no difference in the amplitude or duration of the contraction. Abnormal contraction wave-forms were observed more frequently in post-EIS than in the pre-EIS patients (3/22 vs 12/26, P< 0.05). Various quantitative parameters for GER were not increased in post-EIS compared with pre-EIS patients. Abnormal GER was present in nine of 21 pre-EIS and eight of 17 post-EIS patients (no significant difference). These results suggest that although persistent oesophageal motility changes are frequent after intravariceal EIS, these do not lead to a significant increase in GER.
authors.affiliation: Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
authors.forename: U C
authors.initials: UC
authors.lastname: Ghoshal
authors.forename: V A
authors.initials: VA
authors.lastname: Saraswat
authors.forename: R
authors.initials: R
authors.lastname: Aggarwal
authors.forename: A
authors.initials: A
authors.lastname: Misra
authors.forename: R K
authors.initials: RK
authors.lastname: Dhiman
authors.forename: S R
authors.initials: SR
authors.lastname: Naik
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004932:Esophageal and Gastric Varices / Q000209:etiology / Q000628:therapy*; D004947:Esophagus / Q000503:physiopathology*; D005260:Female; D005764:Gastroesophageal Reflux / Q000209:etiology* / Q000503:physiopathology; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000628:therapy*; D016558:Hemostasis, Endoscopic; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006975:Hypertension, Portal / Q000150:complications; D008297:Male; D008365:Manometry; D018670:Monitoring, Ambulatory; D015911:Sclerotherapy