title: Myocardial effects of desflurane in hamsters with hypertrophic cardiomyopathy.
abstract: BACKGROUND
  The effects of desflurane on myocardial contraction and relaxation in diseased myocardium have not been completely understood.
  
  
  METHODS
  The effects of desflurane (1.8 to 9.4 vol%) in left ventricular papillary muscles of healthy hamsters and those with genetically induced cardiomyopathy (strain BIO 14.6) were investigated in vitro (29 degrees C, pH 7.40, Ca2+ 2.5 mM; stimulation frequency, 3/min) under low (isotony) and high (isometry) load. Data are mean percentages of baseline +/- SD.
  
  
  RESULTS
  Desflurane induced no significant inotropic effect in healthy muscles (maximum unloaded shortening velocity and isometric active force at 9.4 vol%: 97 +/- 9% and 92 +/- 20%, respectively). In contrast, in cardiomyopathic muscles, desflurane induced a moderate negative inotropic effect (maximum unloaded shortening velocity and active force at 9.4 vol%: 84 +/- 19% and 75 +/- 25%, respectively). The negative inotropic effect was more pronounced than that in healthy muscles under low (P < 0.05) but not high load, and even when concentrations were corrected for minimum alveolar concentrations in each strain. Adrenoceptor blockade or pretreatment with reserpine did not modify the inotropic effect of desflurane, suggesting the absence of intramyocardial catecholamine release. However, tyramine also did not induce any significant catecholamine release in hamster myocardium. In both strains, desflurane induced no significant lusitropic effect under low or high load.
  
  
  CONCLUSIONS
  Desflurane had no inotropic effect in healthy muscles and a moderate negative inotropic effect in cardiomyopathic muscles. The absence of desflurane-induced intramyocardial catecholamine release was related to hamster myocardium characteristics.
authors.affiliation: Department of Anesthesiology, CHU Pitié-Salpétrière, Paris, France.
authors.forename: B
authors.initials: B
authors.lastname: Vivien
authors.forename: J L
authors.initials: JL
authors.lastname: Hanouz
authors.forename: P Y
authors.initials: PY
authors.lastname: Gueugniaud
authors.forename: Y
authors.initials: Y
authors.lastname: Lecarpentier
authors.forename: P
authors.initials: P
authors.lastname: Coriat
authors.forename: B
authors.initials: B
authors.lastname: Riou
mesh_terms: D018759:Adrenergic Uptake Inhibitors / Q000494:pharmacology; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D000818:Animals; D002312:Cardiomyopathy, Hypertrophic / Q000235:genetics / Q000503:physiopathology*; D006224:Cricetinae; D000077335:Desflurane; D066298:In Vitro Techniques; D007530:Isoflurane / Q000031:analogs & derivatives* / Q000494:pharmacology; D007537:Isometric Contraction / Q000187:drug effects; D008647:Mesocricetus; D009200:Myocardial Contraction / Q000187:drug effects*; D010210:Papillary Muscles / Q000187:drug effects; D012110:Reserpine / Q000494:pharmacology; D016277:Ventricular Function, Left / Q000187:drug effects
chemical_list: D018759:Adrenergic Uptake Inhibitors; D018685:Anesthetics, Inhalation; D012110:Reserpine; D000077335:Desflurane; D007530:Isoflurane