Two crystal structures of N-acetyltransferases reveal a new fold for CoA-dependent enzymes.
Coenzyme A (CoA) is well known for its importance in various metabolic pathways. The recent determination of the structures of several CoA-dependent N-acylating enzymes highlights the importance of the acyl-CoA molecule for intracellular regulation and reveals a novel fold. The N-acetyltransferase fold defines yet another protein superfamily and adds to the already diverse world of CoA-dependent enzymes.
Modis
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European Molecular Biology Laboratory Postfach, 10.2209 D-69012 Heidelberg, Germany.
Wierenga
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R
D000123:Acetyltransferases / Q000737:chemistry* / Q000378:metabolism; D003065:Coenzyme A / Q000378:metabolism*; D018360:Crystallography, X-Ray; D017510:Protein Folding
D000123:Acetyltransferases; D003065:Coenzyme A