Bioavailability of platinum emitted from automobile exhaust.
A model substance was used which is similar in respect to platinum content of exhaust particles emitted from a three-way-catalytic converter equipped engine. The bioavailability of platinum from such exhaust particles and the kind of platinum species formed in vivo were assessed. An in vitro solubility test showed a solubility of approximately 10 percent of platinum content of the model substance in physiological sodium chloride solution. Two short-term animal studies (8 days) were performed. In all examined rat tissues and body fluids platinum could be detected. In addition, the contribution of the overall bioavailability caused by swallowing a certain amount of the intratracheally applied platinum was evaluated by oral application. It was very low. An analytical method was developed to determine platinum species. Synthetic samples (matrix with a platinum standard solution) were analysed. In rat bronchoalveolar lavage spiked with a platinum standard solution only low molecular complexed platinum was found whereas in rat blood plasma all platinum was bound to proteins. In ongoing studies, the model substance is being tested in a three month rat inhalation study.
Artelt
S
S
Fraunhofer-Institute of Toxicology and Aerosol Research, Hanover, Germany.
Kock
H
H
Nachtigall
D
D
Heinrich
U
U
D000818:Animals; D001682:Biological Availability; D005260:Female; D010984:Platinum / Q000737:chemistry / Q000493:pharmacokinetics*; D051381:Rats; D011917:Rats, Inbred Lew; D014018:Tissue Distribution; D001335:Vehicle Emissions
D001335:Vehicle Emissions; D010984:Platinum