The viral chemokine macrophage inflammatory protein-II is a selective Th2 chemoattractant.
Kaposi's sarcoma (KS) lesions are characterized by a prominent leukocyte infiltrate composed of mononuclear phagocytes and T cells. KS-associated CD4(+) and CD8(+) cells showed predominantly a type II cytokine profile. The CC chemokine viral macrophage inflammatory protein-II (vMIP-II) encoded by the KS-associated herpes virus 8 was a selective chemoattractant for T helper 2 (Th2 cells) and for monocytes, whereas it was inactive on other leukocytes, including Th1 cells, dendritic cells, and natural killer (NK) cells. vMIP-II was an agonist for CCR8, a chemokine receptor selectively expressed on CD4(+) and CD8(+) cells with a type II cytokine profile. Hence, vMIP-II has agonist activity for a chemokine receptor (CCR8), which is preferentially expressed on polarized Th2 cells. The capacity of vMIP-II to attract type II T cells selectively is likely to be a component of the virus strategy to subvert the host immune response.
Sozzani
S
S
Istituto di Ricerche Farmacologiche 'Mario Negri,' Milan, Italy.
Luini
W
W
Bianchi
G
G
Allavena
P
P
Wells
T N
TN
Napolitano
M
M
Bernardini
G
G
Vecchi
A
A
D'Ambrosio
D
D
Mazzeo
D
D
Sinigaglia
F
F
Santoni
A
A
Maggi
E
E
Romagnani
S
S
Mantovani
A
A
D002465:Cell Movement / Q000187:drug effects*; D054426:Chemokine CXCL2; D002630:Chemotactic Factors / Q000378:metabolism / Q000494:pharmacology*; D003713:Dendritic Cells / Q000187:drug effects / Q000473:pathology; D019288:Herpesvirus 8, Human / Q000378:metabolism*; D006801:Humans; D007694:Killer Cells, Natural / Q000187:drug effects / Q000473:pathology; D009000:Monocytes / Q000187:drug effects / Q000473:pathology; D015846:Monokines / Q000378:metabolism* / Q000494:pharmacology; D018418:Th2 Cells / Q000187:drug effects / Q000473:pathology*; D014764:Viral Proteins / Q000378:metabolism / Q000494:pharmacology*
D054426:Chemokine CXCL2; D002630:Chemotactic Factors; D015846:Monokines; D014764:Viral Proteins