[Rickettsioses: their chemoprophylaxis and chemotherapy].
As a result of long-standing screening of chemopreparations of anti-rickettsiosis action in-vitro and in-vivo experiments and their clinical evaluation in the treatment of R. of any etiology, it is established that the most effective ones are those of the 4 groups: tetracyclines (doxicycline, minocyclines), ansamicines (rifampicine), ftorchinolones (cyprofloxacine, ofloxacine, pefloxacine) and the new generation of macrolides (asitromicine, klaritromicine). Since all the studied preparations have only rickettsiosis-static effect, a promising way to finding a rickettsiocidic preparation capable of preventing a possible persistence of a relevant agent in a human body is a combined application of highly effective chemopreparations (doxicycline, in particular) or pefloxacine with lysosomal alkalinizing drugs (chlorochin, ammonium chloride or amantadine). Antibiotics of prolonged anti-rickettsiosis action give a real chance for prevention even with a one-time dose.
Plekhanova
T M
TM
Lukin
E P
EP
Ruchko
V M
VM
Makhlaĭ
A A
AA
Perepelkin
V S
VS
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy* / Q000517:prevention & control*; D006801:Humans
D000900:Anti-Bacterial Agents
Rikketsiozy: khimioprofilaktika i khimioterapiia.