title: PGE2 receptor subtype EP1 antagonist may inhibit central interleukin-1beta-induced fever in rats.
abstract: We have previously reported that central injection of PGE2 induces hyperthermia through its actions on EP1 receptors in rats. Because the increase in local synthesis of PGE2 is assumed to be a necessary process in a fever caused by central injection of interleukin-1beta (IL-1beta), an EP1 receptor antagonist (SC-19220) should inhibit the IL-1beta-induced fever. To test this hypothesis, we observed the effect of SC-19220 on the fever produced by injection of recombinant human IL-1beta (rhIL-1beta) into the lateral cerebroventricle (LCV) in conscious rats. Administration of SC-19220 (100 microgram) into the LCV 15 min before LCV injection of rhIL-1beta (4 ng) suppressed an initial rise in colonic temperature for 30 min, producing a fever with a longer latency to onset and a longer time to peak elevation. SC-19220, given 60 min after the central administration of rhIL-1beta, also suppressed the rhIL-1beta-induced fever 15-60 min after its injection. These findings suggest that the central IL-1beta-induced fever in rats is mediated, at least partly, by activation of EP1 receptors by PGE2.
authors.affiliation: Department of Physiology, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Oka
authors.forename: T
authors.initials: T
authors.lastname: Oka
authors.forename: T
authors.initials: T
authors.lastname: Hori
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001921:Brain / Q000502:physiology*; D003106:Colon / Q000503:physiopathology; D012531:Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide / Q000494:pharmacology*; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage / Q000494:pharmacology; D005334:Fever / Q000139:chemically induced* / Q000517:prevention & control*; D006801:Humans; D007276:Injections, Intraventricular; D007375:Interleukin-1 / Q000008:administration & dosage* / Q000494:pharmacology; D008297:Male; D011448:Prostaglandin Antagonists / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D018078:Receptors, Prostaglandin E / Q000037:antagonists & inhibitors*; D011994:Recombinant Proteins
chemical_list: D007375:Interleukin-1; D011448:Prostaglandin Antagonists; D018078:Receptors, Prostaglandin E; D011994:Recombinant Proteins; D012531:Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; D004121:Dimethyl Sulfoxide