Influence of left ventricular pressures and heart rate on myocardial high-energy phosphate metabolism.
This review describes the effects of changes in left ventricular pressures and heart rate on myocardial high-energy phosphate metabolism. When cardiac workload is substantially increased, creatine kinase flux will increase markedly, phosphocreatine will show a small but detectable decrease, and ATP will not change. In this context, heart rate is a much weaker acute metabolic stimulus than left ventricular developed pressure. However, in heart failure, chronic reduction of heart rate has beneficial effects on alterations of high-energy phosphate metabolism.
Neubauer
S
S
Medizinische Universitätsklinik, Würzburg, FRG.
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D004734:Energy Metabolism / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D009206:Myocardium / Q000378:metabolism*; D010101:Oxygen Consumption / Q000502:physiology; D010725:Phosphocreatine / Q000378:metabolism*; D016277:Ventricular Function, Left / Q000502:physiology*
D010725:Phosphocreatine; D000255:Adenosine Triphosphate