Expression of aromatase in the embryonic and postnatal mouse striatum.
Estrogen influences striatal activity and the development of the nigrostriatal system. This study is concerned with the ontogenetic and postnatal expression of aromatase in the mouse striatum. Aromatase activity and mRNA expression were detectable in the embryonic striatum and increased postnatally with no differences between sexes. Aromatase-positive cells were uniformly distributed within the striatum. These data demonstrate that estrogen formation is an intrinsic property of striatal cells and suggest that estrogen may be important for striatal development and function.
Küppers
E
E
Abteilung Anatomie und Zellbiologie, Universität Ulm, D-89069, Ulm, Germany.
Beyer
C
C
D000818:Animals; D001141:Aromatase / Q000235:genetics* / Q000378:metabolism; D003342:Corpus Striatum / Q000166:cytology / Q000196:embryology* / Q000201:enzymology*; D004967:Estrogens / Q000502:physiology; D005260:Female; D018507:Gene Expression Regulation, Developmental; D015971:Gene Expression Regulation, Enzymologic; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009474:Neurons / Q000201:enzymology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012737:Sex Factors; D013378:Substantia Nigra / Q000166:cytology / Q000196:embryology / Q000201:enzymology
D004967:Estrogens; D001141:Aromatase