title: Experimental surgical treatment for recurrent epistaxis.
abstract: OBJECTIVE
  To evaluate a new technique of submucosal supraperichondrial (SMSP) dissection of the nasal septum and its subsequent effect on the vascularity of the mucosa. A reduction may decrease the rate of recurrent anterior epistaxis.
  
  
  METHODS
  The procedure was performed on one side of the nasal septum of 16 laboratory rabbits. After healing occurred 3 months later, the animals' septa were excised and stained. Both sides were then compared by using standardized microscopic field analysis.
  
  
  RESULTS
  The reduction in both the number of blood vessels on the operated side of the septum and the proportion of area occupied by these vessels was statistically significant (P < .004).
  
  
  CONCLUSIONS
  This technique led to a reduction in the vascularity of the nasal septal mucosa, 3 months after dissection was performed. Healing, which occurs by a process of fibrosis, yielded a less vascularized tissue. Although further laboratory and clinical assessment is recommended, this technique may prove valuable in reducing the rate of recurrent anterior epistaxis.
authors.affiliation: Department of Otolaryngology/Head and Neck Surgery, Hadassah University Hospital, Jerusalem, Israel.
authors.forename: I
authors.initials: I
authors.lastname: Dano
authors.forename: E
authors.initials: E
authors.lastname: Dangoor
authors.forename: J Y
authors.initials: JY
authors.lastname: Sichel
authors.forename: R
authors.initials: R
authors.lastname: Eliashar
mesh_terms: D000818:Animals; D004844:Epistaxis / Q000601:surgery*; D005260:Female; D008297:Male; D009297:Nasal Mucosa / Q000098:blood supply / Q000601:surgery*; D009300:Nasal Septum / Q000601:surgery*; D011817:Rabbits; D012008:Recurrence; D014945:Wound Healing