Genetic variation in paraoxonase-2 is associated with variation in plasma lipoproteins in Canadian Oji-Cree.
We report studies of the association between genetic variation in PON2 and variation in plasma quantitative traits in a sample of 334 non-diabetic Oji-Cree. We detected associations between PON2 variation in codon 148 (Ala --> Gly) and variation in fasting plasma concentrations of total and low-density lipoprotein (LDL) cholesterol and apolipoprotein (apo) B. In particular, homozygotes for a PON2 allele that encoded A148 had significantly higher plasma total, LDL cholesterol and apo B than subjects having the other two genotypes (p < 0.01). Taken together, our results suggest that common genetic variation on chromosome 7q21.3-22.1 in PON2 is associated with significant variation of intermediate traits in plasma lipoprotein metabolism.
Hegele
R A
RA
John P Robarts Research Institute, University of Western Ontario, London, Canada. robert.hegele@rri.on.ca
Harris
S B
SB
Connelly
P W
PW
Hanley
A J
AJ
Tsui
L C
LC
Zinman
B
B
Scherer
S W
SW
D000328:Adult; D000483:Alleles; D043303:Aryldialkylphosphatase; D002170:Canada; D004950:Esterases / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D010641:Phenotype
D008074:Lipoproteins; D004950:Esterases; D043303:Aryldialkylphosphatase; C468411:PON2 protein, human