HIV influence on hematopoiesis at the initial stage of infection.
Alterations in the parameters responsible for the characteristic anemic condition of AIDS patients who are at the final stage of infection have already been established. However, the development of these alterations at the initial stage of infection, where no opportunistic infections occur, needs further study. The goal of this study was to verify whether laboratory alterations observed on patients at the final stages of the disease could already be seen at the beginning of HIV infection, or were the result of opportunistic infections. To that end, HIV-seropositive patients identified by the ELISA test and confirmed by immunofluorescence were screened by infectologist doctors and classified as per the Walter Reed Army Institute System. Results showed that thrombocytopenia occurred at an early stage during HIV infection. The number of leukocytes and erythrocytes diminished progressively as the disease advanced, and levels of hemoglobin, transferrin and serum iron were also diminished with the progression of the disease. These results indicate that the laboratory alterations observed in HIV-seropositive patients during the initial stages were, probably, due to virus infection, because these patients did not present opportunistic infections.
Spada
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C
Clinical Analysis Department, Health Sciences Center, UFSC, Santa Catarina, Brazil. celso@ccs.ufsc.br
Treitinger
A
A
Hoshikawa-Fujimura
A Y
AY
D001772:Blood Cell Count; D004797:Enzyme-Linked Immunosorbent Assay; D004912:Erythrocytes / Q000473:pathology; D015658:HIV Infections / Q000097:blood* / Q000473:pathology; D015497:HIV-1 / Q000302:isolation & purification*; D006410:Hematopoiesis; D006801:Humans; D007962:Leukocytes / Q000473:pathology; D013921:Thrombocytopenia