Application of a standardized cytomegalovirus antigenemia assay in the management of patients with AIDS.
One-hundred twenty AIDS patients, tested by an optimized cytomegalovirus antigenemia (CMV-Ag) assay, were followed over a 6-month period in an attempt to correlate viral (CMV) load with severe CMV organ-specific disease. Among patients available for follow-up, CMV organ-specific disease was present in seven of eight (88%) with pp65 antigen levels > or = 50 cells per 4 x 10(5) polymorphonuclear leukocytes. One-hundred six patients of 107 patients with levels < 50 pp65 reactive cells did not develop CMV organ-specific disease within our 6-month follow-up period. The CMV-Ag assay, as standardized in our clinical setting, served as a marker and predictor of CMV organ-specific disease in our AIDS patient population.
Lipson
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Jane and Dayton Brown and Dayton T. Brown Jr. Virology Laboratory, North Shore University Hospital, New York University School of Medicine, Manhasset, USA.
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Toro
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Kaplan
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Shepp
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D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis* / Q000821:virology; D003587:Cytomegalovirus / Q000276:immunology / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000175:diagnosis* / Q000821:virology; D003588:Cytopathogenic Effect, Viral; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D008297:Male; D010750:Phosphoproteins / Q000097:blood*; D016133:Polymerase Chain Reaction / Q000379:methods; D019562:Viral Load; D014776:Virus Cultivation
D010750:Phosphoproteins