Meningioma in long-term survivors after allogeneic bone marrow transplantation.
Late complications occurring after allogeneic bone marrow transplant (BMT) are increasingly reported, since more patients survive. Among these late complications, solid tumors are of particular clinical concern. Only malignant brain tumors have been reported (astrocytoma, glioblastoma). We describe two cases of meningiomas developing 13 and 15 years after the graft. Occurrence of such benign tumors has been described after treatment of ALL, but not following allogeneic BMT. It is important to consider the diagnosis of meningioma in long-term survivors presenting with neurological symptoms.
Meignin
V
V
Department of Pathology, Hôpital Saint-Louis, Paris, France.
Gluckman
E
E
Gambaraelli
D
D
Devergie
A
A
Ramee
M P
MP
Janin
A
A
Socié
G
G
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D006801:Humans; D007938:Leukemia / Q000473:pathology* / Q000628:therapy*; D008297:Male; D008577:Meningeal Neoplasms / Q000209:etiology / Q000473:pathology*; D008579:Meningioma / Q000209:etiology / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000209:etiology / Q000473:pathology*; D014184:Transplantation, Homologous