title: [The NADPH-diaphorase activity of the bronchial epithelium in chronic lung diseases].
abstract: Topochemistry and activity of NADP-H diaphorase co-localized with NO synthase was examined in operative material of lungs from patients with bronchial asthma (BA), chronic nonobstructive bronchitis (CNO) and chronic obstructive bronchitis. The enzyme activity was found to be dependent upon the types of obstruction and inflammation. In CNO the state of NO synthase was not changed. In conditions of progressive irreversible airway obstruction the enzyme activity was augmented in small bronchi epithelium and alveolar macrophages (AM). In reversible obstruction the activity of NO synthase was not changed in the epithelium but appeared high in resident cells of inflammation--AM and mast cells.
authors.affiliation: Histology Department, Medical University of Vladivostok.
authors.forename: V A
authors.initials: VA
authors.lastname: Nevzorova
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Protopopova
authors.forename: E V
authors.initials: EV
authors.lastname: Eliseeva
authors.forename: B I
authors.initials: BI
authors.lastname: Gel'tser
mesh_terms: D000328:Adult; D001249:Asthma / Q000201:enzymology*; D001980:Bronchi / Q000201:enzymology*; D001991:Bronchitis / Q000201:enzymology*; D002908:Chronic Disease; D004848:Epithelium / Q000201:enzymology; D006651:Histocytochemistry; D006801:Humans; D008297:Male; D008875:Middle Aged; D009252:NADPH Dehydrogenase / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism
chemical_list: D019001:Nitric Oxide Synthase; D009252:NADPH Dehydrogenase
vernacular_title: Aktivnost' NADPH-diaforazy épiteliia bronkhov pri khronicheskikh zabolevaniiakh legkikh.