title: Studies on the nature of cytotoxic effects induced by dihydralazine.
abstract: The effects of scavengers on the cytotoxicity of dihydralazine were evaluated. Pretreatment of two kinds of mammalian cells cultured in vitro with catalase or sodium dismutase abolished partially or almost totally the effects of the drug. Hydroxyl radicals scavengers dimethylsulphoxide and D-mannitol minimized the cytotoxic response of both kinds of cells.
authors.affiliation: Drug Institute, Warsaw, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Marczewska
authors.forename: J H
authors.initials: JH
authors.lastname: Koziorowska
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004078:Dihydralazine / Q000633:toxicity*; D016166:Free Radical Scavengers / Q000494:pharmacology; D000882:Haplorhini
chemical_list: D016166:Free Radical Scavengers; D004078:Dihydralazine