title: Hypophyseal-pituitary-adrenal axis in autoimmune and rheumatic diseases.
abstract: This article discusses the effects of sex steroids and anterior pituitary hormones on the immune system. Data from clinical and experimental studies on the effects of CRH, FSH, LH, and prolactin are reviewed. This is followed by a summary of results from our studies on the effects of FSH, LH, and prolactin on PBMC, CD4+ cells, and CD8+ cells in vitro.
authors.affiliation: A.I. duPont Institute of the Nemours Foundation, Pediatric Rheumatology, Wilmington, DE 19899, USA.
authors.forename: B H
authors.initials: BH
authors.lastname: Athreya
authors.forename: P
authors.initials: P
authors.lastname: Rettig
authors.forename: W V
authors.initials: WV
authors.lastname: Williams
mesh_terms: D000293:Adolescent; D001171:Arthritis, Juvenile / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology*; D003346:Corticotropin-Releasing Hormone / Q000276:immunology; D005260:Female; D005640:Follicle Stimulating Hormone / Q000276:immunology; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000276:immunology*; D007986:Luteinizing Hormone / Q000276:immunology; D008297:Male; D010913:Pituitary-Adrenal System / Q000276:immunology*; D011388:Prolactin / Q000276:immunology; D011627:Puberty / Q000276:immunology; D012216:Rheumatic Diseases / Q000276:immunology*; D012741:Sexual Maturation / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000187:drug effects
chemical_list: D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D003346:Corticotropin-Releasing Hormone