title: X-ray CT monitoring of iceball growth and thermal distribution during cryosurgery.
abstract: X-ray CT is able to image the internal architecture of frozen tissue. Phantoms of distilled water, a saline-gelatin mixture, lard and a calf liver-gelatin suspension cooled by a plastic tube acting as a long liquid nitrogen cryoprobe were used to study the relationship between Hounsfield unit (HU) values and temperature. There is a signature change in HU value from unfrozen to completely frozen tissue. No discernible relation exists between temperature in a completely frozen tissue and its HU value for the temperature range achieved with commercial cryoprobes. However, such a relation does exist in the typically narrow region of phase change and it is this change in HU value that is the parameter of concern for quantitative monitoring of the freezing process. Calibration of temperature against change in HU value allows a limited set of isotherms to be generated in the phase change region for direct monitoring of iceball growth. The phase change temperature range, mid-phase change temperature and the absolute value of HU change from completely frozen to unfrozen tissue are shown to be sensitive to the medium. Modelling of the temperature distribution within the region of completely frozen phantom using the infinite cylinder solution to the Fourier heat equation allows the temperature history of the phantom to be predicted. A set of isotherms, generated using a combination of thermal modelling and calibrated HU values demonstrates the feasibility of routine x-ray CT assisted cryotherapy. Isotherm overlay will be a major aid to the cryosurgeon who adopts a fixed target temperature as the temperature below which there is a certainty of ablation of the diseased tissue.
authors.affiliation: Department of Oncology, Tom Baker Cancer Centre, Calgary, Canada.
authors.forename: G A
authors.initials: GA
authors.lastname: Sandison
authors.forename: M P
authors.initials: MP
authors.lastname: Loye
authors.forename: J C
authors.initials: JC
authors.lastname: Rewcastle
authors.forename: L J
authors.initials: LJ
authors.lastname: Hahn
authors.forename: J C
authors.initials: JC
authors.lastname: Saliken
authors.forename: J G
authors.initials: JG
authors.lastname: McKinnon
authors.forename: B J
authors.initials: BJ
authors.lastname: Donnelly
mesh_terms: D000818:Animals; D055592:Biophysical Phenomena; D001703:Biophysics; D002417:Cattle; D003452:Cryosurgery; D006801:Humans; D007053:Ice; D066298:In Vitro Techniques; D008991:Monitoring, Physiologic; D019047:Phantoms, Imaging; D013696:Temperature; D014057:Tomography, X-Ray Computed
chemical_list: D007053:Ice