title: A new elastographic method for estimation and imaging of lateral displacements, lateral strains, corrected axial strains and Poisson's ratios in tissues.
abstract: A major disadvantage of the current practice of elastography is that only the axial component of the strain is estimated. The lateral and elevational components are basically disregarded, yet they corrupt the axial strain estimation by inducing decorrelation noise. In this paper, we describe a new weighted interpolation method operating between neighboring RF A-lines for high precision tracking of the lateral displacement. Due to this high lateral-tracking precision, quality lateral elastograms are generated that display the lateral component of the strain tensor. These precision lateral-displacement estimates allow a fine correction for the lateral decorrelation that corrupts the axial estimation. Finally, by dividing the lateral elastogram by the axial elastogram, we are able to produce a new image that displays the distribution of Poisson's ratios in the tissue. Results are presented from finite-element simulations and phantoms as well as in vitro and in vivo experiments.
authors.affiliation: Department of Radiology, The University of Texas Medical School, Houston 77030, USA.
authors.forename: E
authors.initials: E
authors.lastname: Konofagou
authors.forename: J
authors.initials: J
authors.lastname: Ophir
mesh_terms: D001783:Blood Flow Velocity; D001943:Breast Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000503:physiopathology; D003198:Computer Simulation; D004548:Elasticity; D005260:Female; D018226:Fibroadenoma / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008875:Middle Aged; D008954:Models, Biological; D019047:Phantoms, Imaging; D016012:Poisson Distribution; D014463:Ultrasonography