Non-peptidic corticotropin-releasing hormone receptor type 1 antagonist reverses restraint stress-induced shortening of sodium pentobarbital-induced sleeping time of rats: evidence that an increase in arousal induced by stress is mediated through CRH receptor type 1.
Stress shortens sodium pentobarbital (PbNa)-induced sleeping time through corticotropin-releasing hormone (CRH) in rats. We investigated whether this effect of brain CRH is mediated by CRH receptor type 1 (CRHR1) using a non-peptidic CRHR1 antagonist in rats. A 60 min period of restraint significantly shortened PbNa-induced sleeping time. This shortening was completely reversed by peripheral administration of CRHR1 antagonist. These results suggest that the stress-induced increase in arousal is mediated by CRHR1.
Arai
K
K
Department of Physiology, Nippon Medical School, Tokyo, Japan. arai-keiko/phys2@nms.ac.jp
Ohata
H
H
Shibasaki
T
T
D000818:Animals; D001143:Arousal / Q000502:physiology; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D018019:Receptors, Corticotropin-Releasing Hormone / Q000037:antagonists & inhibitors* / Q000502:physiology; D012149:Restraint, Physical; D012890:Sleep / Q000187:drug effects* / Q000502:physiology; D013312:Stress, Physiological / Q000209:etiology / Q000503:physiopathology*; D013997:Time Factors
D006993:Hypnotics and Sedatives; D011725:Pyridines; D011743:Pyrimidines; D018019:Receptors, Corticotropin-Releasing Hormone; C117406:CRA1000; D010424:Pentobarbital