title: Success of surgery for primary aldosteronism judged by residual autonomous aldosterone production.
abstract: Since February 1996 we have prospectively assessed residual adrenal autonomy by the fludrocortisone suppression test (FST) in 23 patients 3 months after unilateral adrenalectomy for Conn syndrome and in 45 patients after a longer interval. In regard to blood pressure, 36 (53%) patients were cured of hypertension and the remaining 32 (47%) patients had improved hypertension control at the time of their latest postoperative clinical assessment. In regard to the outcome of surgery, patients who achieved normal suppressibility of aldosterone were regarded as cured, and those who had greater suppressibility after surgery were considered improved. Time since surgery for the whole group averaged 26 months. By these biochemical criteria, 42 patients (62%) were cured by surgery, and the rest improved; 16 (76%) of 21 women were cured, and 26 (55%) of 47 men. The women (mean +/- SD age 47 +/- 11 years) were significantly (p < 0.05) younger than the men (52 +/- 9 years). Preoperative aldosterone levels before and after FST were similar in the cured and improved groups and fell significantly (p < 0.01) in both groups following surgery. After surgical reduction of autonomous aldosterone production, mean plasma renin activity levels increased sixfold in the cured group and threefold in the improved group. Surgical mortality in this group of 68 patients with Conn syndrome was zero.
authors.affiliation: Hypertension Unit, University Department of Medicine, Greenslopes Hospital, Brisbane, Queensland, Australia.
authors.forename: J C
authors.initials: JC
authors.lastname: Rutherford
authors.forename: W L
authors.initials: WL
authors.lastname: Taylor
authors.forename: M
authors.initials: M
authors.lastname: Stowasser
authors.forename: R D
authors.initials: RD
authors.lastname: Gordon
mesh_terms: D000328:Adult; D000368:Aged; D000450:Aldosterone / Q000097:blood*; D005260:Female; D005438:Fludrocortisone / Q000494:pharmacology; D006801:Humans; D006929:Hyperaldosteronism / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D000450:Aldosterone; D005438:Fludrocortisone