[Preventive therapy of opiate addiction with naltrexone].
The trial included 120 patients with opiates addiction: the study group (60 patients) and a control one (60 individuals) which were similar in sex, age and clinical peculiarities of the disease. Naltrexon was administered prophylactically to the patients of the study group during 6 months and longer, while the patients of the control group didn't receive naltrexon. Simultaneously, a program of common therapy and rehabilitation concerning both groups was performed during 6 months. It was established that application of naltrexon decreased probability of relapse of drug abuse, facilitated an inclusion of a patient into a program of therapy and rehabilitation, increased a number and quality of remissions as well as it also decreased a tendency to alcohol and sedative drugs administration. Naltrexon had no side effects and was well tolerated by the patients. 8 follow-up cases of treatment with metadone in some foreign clinics are presented. These observations and literary data show that prophylactic properties of metadone are less pronounced as compared with naltrexon.
Sivolap
Iu P
IuP
Savchenkov
V A
VA
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D009271:Naltrexone / Q000627:therapeutic use*; D009292:Narcotic Antagonists / Q000627:therapeutic use*; D009294:Narcotics; D019966:Substance-Related Disorders / Q000188:drug therapy*
D009292:Narcotic Antagonists; D009294:Narcotics; D009271:Naltrexone
Preventivnaia terapiia opiĭnoĭ narkomanii naltreksonom]