[Lipanor treatment of atherogenic hyperlipoproteinemia].
OBJECTIVE
The study of the hypolipidemic efficiency, safety and tolerance of ciprofibrate (lipanor) in therapy of atherogenic hyperlipoproteinemia.


METHODS
The trial included 14 hypertensive postmenopausal females, 14 patients with diabetes mellitus type II, 14 males with coronary heart disease and primary hyperlipoproteinemia (total cholesterol > 6.5 mmol/l, triglycerides < 4.5 mmol/l under low-cholesterol diet). Lipanor was given for 12 weeks in a daily single dose 100 mg in the morning. Lipids and other biochemical indices were measured in a fasting state after 1 and 3 months of lipanor treatment.


RESULTS
After 1 month of lipanor treatment there was a 22-30%, 24-49% decrease in the level of low-density lipoprotein cholesterol, triglycerides, respectively. High-density lipoprotein cholesterol increased by 16%. The hypolipidemic effect of lipanor persisted for 3 months during which triglycerides continued to fall (up to 38.5%). Lipanor was well tolerated, only one patient with diabetes mellitus had hyperactivity of creatine phosphokinase manifesting with clinical symptoms (the drug was discontinued). 3 patients developed mild side effects. Alkaline phosphatase activity inhibited in all the groups by 25-41%.


CONCLUSIONS
Lipanor is a highly effective, safe hypolipidemic drug with good tolerance. It can be recommended for correction of atherogenic hyperlipoproteinemia in patients at high risk of atherosclerosis progression.
Susekov
A V
AV
Tvorogova
M G
MG
Arabidze
G G
GG
Kukharchuk
V V
VV
D002784:Cholesterol / Q000097:blood; D002995:Clofibric Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003324:Coronary Artery Disease / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D018450:Disease Progression; D004334:Drug Administration Schedule; D005260:Female; D058607:Fibric Acids; D005500:Follow-Up Studies; D006801:Humans; D006951:Hyperlipoproteinemias / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D008074:Lipoproteins / Q000097:blood / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012449:Safety; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood
D058607:Fibric Acids; D000960:Hypolipidemic Agents; D008074:Lipoproteins; D014280:Triglycerides; D002995:Clofibric Acid; D002784:Cholesterol; C019304:ciprofibrate
Lipanor pri lechenii bol'nykh s aterogennymi giperlipoproteinemiiami.