title: Does methocarbamol affect fatigue markers in the low-back electromyogram?
abstract: Many low-back patients undergo electromyography (EMG)-based evaluations of muscle performance but present to the clinic after being prescribed muscle relaxants. The question that needed to be addressed was, do centrally acting muscle relaxants (methocarbamol; Robaxin) affect the EMG spectral indices of muscle fatigue that are often used to assess muscle performance. Participants performed an isometric spine extension protocol involving a 30 s fatigue exertion trial, then 1 min rest, and finally a 10 s long repeat exertion trial, at a 60% maximum voluntary contraction (MVC) level of exertion. Seven men were tested on two separate days (approximately 3-7 days apart), one day while medicated (six doses) with Robaxin and on another while not medicated. Specifically, the following parameters were studied in the bilateral multifidus (L5), lower erector spinae (L3) and upper erector spinae (T9): the slope of median power frequencies (MPFs) over the duration of the trial and the initial y-intercept of the MPF. The results generally suggest that methocarbamol (Robaxin) does not have any significant affect on the EMG median power frequency of the extensors during a fatiguing contraction followed by a repeat exertion, at least in normal people (one exception was observed--one side of multifidus at L5). However, given that this appears to be the first study of its kind, and that a relatively small number of subjects were used in this study, further investigation is needed to make a definitive conclusion about the effects of this drug on the several features of the electromyogram, over a broad spectrum of the clinical population performing a wider variety of tasks.
authors.affiliation: Department of Kinesiology, Faculty of Applied Health Sciences, University of Waterloo, Ontario, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Boakes
authors.forename: J P
authors.initials: JP
authors.lastname: Peach
authors.forename: S M
authors.initials: SM
authors.lastname: McGill
mesh_terms: D000328:Adult; D004576:Electromyography / Q000187:drug effects*; D006801:Humans; D007537:Isometric Contraction / Q000502:physiology; D008161:Lumbosacral Region / Q000502:physiology*; D008297:Male; D008721:Methocarbamol / Q000494:pharmacology*; D018763:Muscle Fatigue / Q000187:drug effects / Q000502:physiology*; D009125:Muscle Relaxants, Central / Q000494:pharmacology*; D005082:Physical Exertion / Q000502:physiology; D012016:Reference Values; D012146:Rest / Q000502:physiology
chemical_list: D009125:Muscle Relaxants, Central; D008721:Methocarbamol