title: Cytomorphological features, AgNOR counts and c-erb B-2 in carcinoma breast.
abstract: The present study was designed to evaluate the cytomorphological features (nuclear grade and smear pattern) and AgNOR counts in 60 cases of carcinoma breast. The smears were stained with May Gruenwald Giemsa (MGG) and Papanicolaou stains. Silver staining nucleolar organiser region (AgNOR) counts and c-erb B-2 immunostaining were also done in each case. The smear pattern was assessed and classified as 'typical', 'cluster predominant' or 'individual cell type', and the nuclei were graded as grade I, II or III. Smear pattern and nuclear grade were found to be related variables. A significant association was found between nuclear grade and AgNOR counts (p = 0.03). Also postmenopausal women had statistically significant higher nuclear grades and less cohesive cell clusters as compared to premenopausal women. Twenty-three carcinoma breast were positive for c-erb B-2, of these 14 were postmenopausal women.
authors.affiliation: Department of Pathology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi.
authors.forename: S K
authors.initials: SK
authors.lastname: Sinha
authors.forename: U R
authors.initials: UR
authors.lastname: Singh
authors.forename: A
authors.initials: A
authors.lastname: Bhatia
authors.forename: S
authors.initials: S
authors.lastname: Gupta
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor; D001707:Biopsy, Needle / Q000379:methods; D001943:Breast Neoplasms / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology* / Q000556:secondary; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D009697:Nucleolus Organizer Region / Q000473:pathology*; D017698:Postmenopause; D011379:Prognosis; D011446:Prospective Studies; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D018719:Erb-b2 Receptor Tyrosine Kinases