title: Screening for in vitro anti-tumor-promoting activities of edible plants from Indonesia.
abstract: A total of 135 methanol extracts from 48 plant families (107 species) of edible Indonesian plants were screened for their in vitro anti-tumor-promoting activities using the tumor promoter 12-O-hexadecanoylphorbol-13-acetate (HPA)induced Epstein-Barr virus (EBV) activation test in Raji cells. Examined at a concentration of 200 mg/ml, 71% of the extracts inhibited EBV activation by 30% or more. The rate is comparable to the rate observed in our previous tests of edible Thai (60%) plants and much higher than the rate (26%) observed with Japanese plants. In particular, the plant families Zingiberaceae (13/13 active) and Umbelliferae (7/8 active) are suggested to be desirable sources of effective cancer-preventive agents because of the strikingly high frequency of inhibitory activity. Thus, a high potential of edible Southeast Asian plants for cancer chemoprevention is indicated.
authors.affiliation: Department of Biotechnological Science, Faculty of Biology-Oriented Science and Technology, Kinki University, Iwade-Uchita, Wakayama, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Murakami
authors.forename: H
authors.initials: H
authors.lastname: Morita
authors.forename: R
authors.initials: R
authors.lastname: Safitri
authors.forename: A
authors.initials: A
authors.lastname: Ramlan
authors.forename: K
authors.initials: K
authors.lastname: Koshimizu
authors.forename: H
authors.initials: H
authors.lastname: Ohigashi
mesh_terms: D000970:Antineoplastic Agents / Q000302:isolation & purification*; D019661:Apiaceae / Q000737:chemistry; D019607:Brassicaceae / Q000737:chemistry; D018890:Chemoprevention; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D019665:Euphorbiaceae / Q000737:chemistry; D005638:Fruit / Q000737:chemistry; D006801:Humans; D007214:Indonesia; D007564:Japan; D016393:Lymphoma, B-Cell; D010945:Plants, Edible / Q000737:chemistry*; D014675:Vegetables / Q000737:chemistry; D019862:Zingiberales / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents