No development of tolerance to analgesia by repeated administration of H1 antagonists.
The effect produced by repeated administration of the H1-antihistaminics diphenhydramine, promethazine and pyrilamine on their ability to induce antinociception was evaluated in the mouse hot-plate and abdominal constriction tests. Contrary to morphine, baclofen and oxotremorine, the three H1 antagonists investigated did not promote the development of tolerance to the analgesic effect after 14 days of repeated treatment. H1 antagonists could, therefore, represent a promising pharmacological approach to the management of chronic pain.
Ghelardini
C
C
Department of Pharmacology, University of Florence, Italy.
Galeotti
N
N
Bartolini
A
A
D000698:Analgesia; D000818:Animals; D004155:Diphenhydramine / Q000008:administration & dosage / Q000494:pharmacology*; D004361:Drug Tolerance; D005260:Female; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects; D017288:Pain Threshold / Q000187:drug effects; D004856:Postural Balance / Q000187:drug effects; D011398:Promethazine / Q000008:administration & dosage / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects
D006634:Histamine H1 Antagonists; D004155:Diphenhydramine; D011398:Promethazine