Cellular mechanism of pulsatile LHRH release.
One of the most intriguing characteristics of the luteinizing hormone-releasing hormone (LHRH) neuronal system in mammalian species is the pulsatile release pattern of the peptide from the hypothalamus into the portal circulation, which is essential for the maintenance of normal reproductive function. In this review article the new concept that LHRH neurons possess an endogenous pulse-generating mechanism, but this is modified by other neuronal and nonneuronal inputs is discussed.
Terasawa
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Department of Pediatrics, and Center for Neuroscience, University of Wisconsin-Madison, 1223 Capitol Court, Madison, Wisconsin, 53715-1299, USA.
D000818:Animals; D007987:Gonadotropin-Releasing Hormone / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007031:Hypothalamus / Q000166:cytology / Q000378:metabolism*; D009474:Neurons / Q000502:physiology*
D007987:Gonadotropin-Releasing Hormone