[The content of phosphoinositides in the biological membranes of different types of muscle fibers].
The content of phosphoinositids in biomembranes of slow (m.soleus) and fast (m. extensor digitorum longus) twitch muscular fibres (MF) was studied. Biochemical differences in different MF of fast and slow muscles were detected. The content of phosphotidylinosites in plasma membranes, mitochondrial and sarcoplasmic reticulum membranes of fast twitch MF was on average 1.28 times higher than in slow ones. The predominance of phosphatidylinositol-3,4,5-triphosphates in fast twitch MF over slow twitch MF was noted. The content of phosphatidylinoitol-3,4,5-triphosphates in plasma membranes, mitochondrial and sarcoplasmic reticulum membranes of slow twitch MF was 3, 2.35 and 1.25 times higher than in fast twitch MF. It was found that phosphoinositide content in biomembranes of different type MF was unequal which may be used to improve the expansion of understanding of the role of intracellular mediators in MF phenotype regulation.
Solov'ev
V A
VA
Histology Department, State Medical Academy of Tver.
Sliusar'
N N
NN
Shinkarenko
T V
TV
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism / Q000648:ultrastructure; D008854:Microscopy, Electron; D018485:Muscle Fibers, Skeletal / Q000378:metabolism* / Q000648:ultrastructure; D018482:Muscle, Skeletal / Q000378:metabolism / Q000648:ultrastructure; D010716:Phosphatidylinositols / Q000378:metabolism*; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism
D010716:Phosphatidylinositols; D013385:Succinate Dehydrogenase
Soderzhanie fosfoinozitidov v biologicheskikh membranakh myshechnykh volokin razlichnykh tipov.