title: Modern therapy of chronic wounds with respect to radiation.
abstract: BACKGROUND
  Descriptions of wound care techniques have been found in some of the oldest archeological findings and chronic wounds have been threaded man thousands of years. However, only in the last few decades substantial progress has been made in understanding the cellular and biochemical processes relevant in normal healing.
  
  
  METHODS
  Wound healing is a complex process involving a variety of different cells, proteins, chemoattractants, proteinases and growth factors. The normal repair process is a coordinated cellular and biochemical event and can be characterized by 3 different healing phases (inflammatory, proliferative, and remodeling phase). Certain pathophysiologic conditions and metabolic disorders alter this preprogrammed course, leading to delayed healing or chronic non-healing wounds.
  Especially irradiation can complicate tissue repair and surgical wound healing. Therefore this article will review the basic understanding of the wound healing process and the knowledge of modern surgical and conservative wound therapy from a surgical point of view, which is essential to surpass pathophysiological situations and avoid chronic wounds.
authors.affiliation: Department of Trauma, Hand, and Reconstructive Surgery, University of Saarland, Homburg. CHJFRA@MED-RZ.UNI-SB.DE
authors.forename: J
authors.initials: J
authors.lastname: Frank
authors.forename: J H
authors.initials: JH
authors.lastname: Barker
authors.forename: I
authors.initials: I
authors.lastname: Marzi
authors.forename: W
authors.initials: W
authors.lastname: Mutschler
mesh_terms: D002908:Chronic Disease; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D007249:Inflammation; D008954:Models, Biological; D011832:Radiation Injuries / Q000628:therapy*; D011878:Radiotherapy / Q000009:adverse effects*; D014945:Wound Healing / Q000502:physiology*
chemical_list: D006133:Growth Substances