title: [Studies of the distribution of lipofuscin in the retinal pigment epithelium using high-resolution TV laser scanning ophthalmoscopy].
abstract: BACKGROUND
  The fundus autofluorescence imaging technique has been modified allowing improved image resolution (768 x 572 pixel). We present results of fundus autofluorescence studies using this technique.
  
  
  METHODS
  Fundus autofluorescence was studied in 286 eyes of 143 patients with retinitis pigmentosa, macular dystrophies and age-related macular degeneration using a confocal laser scanning ophthalmoscope prototype (Zeiss, Oberkochen; excitation wavelength: 488 nm, cut-off filter at 521 nm).
  
  
  RESULTS
  The spatial distribution of autofluorescence was different in all diseased eyes investigated compared to the normal pattern of fundus autofluorescence. Each disorder showed a specific fundus autofluorescence appearance.
  
  
  CONCLUSIONS
  The advanced technique of imaging fundus autofluorescence allows detailed studies of the lipofuscin distribution. In vivo analysis of the dynamics of accumulation and degradation of lipofuscin in eyes with tapeto-retinal dystrophies and age-related macular disease may contribute to elucidation of the pathogenesis of these disorders.
authors.affiliation: Institute of Ophthalmology and Moorfields Eye Hospital, London.
authors.forename: A
authors.initials: A
authors.lastname: von Rückmann
authors.forename: K G
authors.initials: KG
authors.lastname: Schmidt
authors.forename: F W
authors.initials: FW
authors.lastname: Fitzke
authors.forename: A C
authors.initials: AC
authors.lastname: Bird
authors.forename: K W
authors.initials: KW
authors.lastname: Jacobi
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008062:Lipofuscin / Q000378:metabolism*; D008297:Male; D018613:Microscopy, Confocal / Q000295:instrumentation* / Q000379:methods*; D008875:Middle Aged; D009887:Ophthalmoscopy / Q000379:methods*; D010857:Pigment Epithelium of Eye / Q000737:chemistry* / Q000473:pathology; D013690:Television
chemical_list: D008062:Lipofuscin
vernacular_title: Lipofuszinverteilung im retinalen Pigmentepithel. Untersuchungen mit hochauflösender Laser Scanning Ophthalmoskopie.