The role of L-arginine in hypertension and nephrotoxicity.
The L-arginine-nitric oxide pathway appears to play an important role in systemic hypertension, progressive renal disease, nephrotoxicity (lead poisoning), inflammation and atherosclerosis. Interactions of nitric oxide with other systems (renin-angiotensin, endothelins, eicosanoids, cytokines and other regulators of inflammation) have been described. These interactions may be important in disease states.
Klahr
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Department of Medicine, Barnes-Jewish Hospital (North Campus), Washington University School of Medicine, St Louis, MO 63110-1092, USA. sklahr@imgate.wustl.edu
D000818:Animals; D001120:Arginine / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D007674:Kidney Diseases / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D007855:Lead Poisoning / Q000150:complications; D009569:Nitric Oxide / Q000096:biosynthesis*
D009569:Nitric Oxide; D001120:Arginine