title: Design of practical T2-selective RF excitation (TELEX) pulses.
abstract: Traditional T2-based imaging techniques are geared toward imaging long-T2 species. Traditional techniques are, therefore, not optimal in clinical situations where the information of interest lies in the short-T2 species. T2-selective RF excitation (TELEX) is a technique for obtaining a T2-based contrast that highlights short-T2 values while suppressing long-T2 values-opposite to traditional T2 contrast. Previously, TELEX has been demonstrated qualitatively to highlight only very short-T2 values (T2 approximately 0.001 s). When applied to longer T2 values (T2 > or = 0.01 s), TELEX becomes sensitive to deltaB0 non-uniformities. This restricts its application to problems in which the T2 of interest is very short. In this study, TELEX is characterized quantitatively. Furthermore, a bandwidth broadening scheme is developed that reduces the deltaB0 sensitivity of TELEX. This permits the technique to be applied to longer T2 values. The capabilities and limitations of a practical implementation of TELEX are discussed.
authors.affiliation: Department of Medical Biophysics, Sunnybrook Health Science Centre, University of Toronto, North York, Ontario, Canada.
authors.forename: M S
authors.initials: MS
authors.lastname: Sussman
authors.forename: J M
authors.initials: JM
authors.lastname: Pauly
authors.forename: G A
authors.initials: GA
authors.lastname: Wright
mesh_terms: D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000706:statistics & numerical data; D012680:Sensitivity and Specificity; D012985:Software Design; D013997:Time Factors