Estradiol-releasing vaginal ring delivery system for urogenital atrophy. Experience over the past decade.
OBJECTIVE
To critically assess the world literature on the efficacy and safety of the vaginal ring estradiol delivery system for the local treatment of urogenital atrophy due to hypoestrogenism.


METHODS
Published data over the past decade on the vaginal ring delivery system were reviewed.


RESULTS
Data from comparative clinical trials indicate that the vaginal ring delivery system is comparable in efficacy, safety and tolerability to other vaginal delivery systems and may enhance compliance because of its ease of use.


CONCLUSIONS
The vaginal ring delivery system offers an alternative to other vaginal delivery systems with the advantages of accurate and sustained dosing and minimal need for patient intervention.
Bachmann
G
G
Department of Obstetrics and Gynecology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick 08903, USA.
D000368:Aged; D001284:Atrophy; D004958:Estradiol / Q000097:blood / Q000627:therapeutic use*; D015914:Estrogen Replacement Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010342:Patient Acceptance of Health Care; D010570:Pessaries; D017698:Postmenopause / Q000187:drug effects* / Q000502:physiology* / Q000523:psychology; D016896:Treatment Outcome; D014566:Urogenital System / Q000187:drug effects* / Q000473:pathology*
D004958:Estradiol