title: [The concept of "preclinical arterial hypertension" - in light of non-invasive, ambulatory blood pressure monitoring].
abstract: In clinical medicine it is possible to find subjects who show initial signs of hypertensive damage being normotensive at the "casual" sphygmomanometry. In order to verify whether or not these subjects are "true normotensives", it was applied the noninvasive ambulatory monitoring of blood pressure (BP). Five studies were performed: I. Normotensives with initial hypertensive retinopathy; II. normotensives with initial hypertensive cardiohypertrophy; III. Normotensives with initial hypertensive cardiohypertrophy of the transplanted heart; IV. Normotensive pregnant women with altered uterine blood flow; V. Normotensive pregnant women with intrauterine growth retardation. From all the studies, it was possible to derive that the subjects were all true normotensive. However, they were characterized by BP values on average higher than those of their controls, but below the reference limits given by WHO. Because of the relative elevation of BP, it was possible to argue that there exists a BP regimen which is potentially dangerous for the target organs, even though there is no evidence of manifest arterial hypertension. Such a hemodynamic condition causing hypertensive cardiovascular damage was defined "arterial pre-hypertension".
authors.affiliation: II Cattedra di Clinica Oculistica, Università La Sapienza, Roma. cugini@axrma.uniroma.it
authors.forename: P
authors.initials: P
authors.lastname: Cugini
authors.forename: S
authors.initials: S
authors.lastname: Fontana
authors.forename: A M
authors.initials: AM
authors.lastname: Pellegrino
authors.forename: P
authors.initials: P
authors.lastname: Lucia
authors.forename: G
authors.initials: G
authors.lastname: Stirati
authors.forename: F
authors.initials: F
authors.lastname: Cruciani
authors.forename: G
authors.initials: G
authors.lastname: Scibilia
authors.forename: A
authors.initials: A
authors.lastname: Pachì
mesh_terms: D001783:Blood Flow Velocity; D018660:Blood Pressure Monitoring, Ambulatory; D006332:Cardiomegaly / Q000209:etiology; D002940:Circadian Rhythm; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000175:diagnosis* / Q000503:physiopathology; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000175:diagnosis; D012164:Retinal Diseases / Q000209:etiology; D019722:Sphygmomanometers; D014599:Uterus / Q000098:blood supply
vernacular_title: Il concetto di "pre-ipertensione arteriosa" alla luce del monitoraggio ambulatorio non-invasivo della pressione arteriosa.