title: [Effects left ventricle asynchrony on systolic and diastolic function in patients with non-ischemic heart failure].
abstract: BACKGROUND
  The asynchrony of the left ventricle--i.e., its nonuniform contraction and relaxation--is an important factor for left ventricular function. Heart failure is often related to abnormal systolic function, sometimes associated with a diastolic dysfunction. We studied the relationship of left ventricular asynchrony to left ventricular function in patients with nonischemic heart failure.
  
  
  METHODS
  Radionuclide angiography at rest was performed in 25 patients with nonischemic heart failure and in 26 age and sex matched normal subjects. In addition to ejection fraction and peak filling rate, two indices of left ventricular asynchrony were calculated: the coefficient of variation of regional time to end systole and the coefficient of variation of regional time to peak filling rate. These factors indicate how disperse are the regional values of time to end systole and of time to peak filling rate. In fact, the higher the value, the greater the asynchrony.
  
  
  RESULTS
  A significant (r = .46, p < .05) inverse correlation was found between the ejection fraction and the coefficient of variation of regional time to end systole in both the normal subjects and the heart failure patients, while the ejection fraction correlated significantly (r = .46, p < .05) with the coefficient of variation of regional time to peak filling rate only in the patients. Moreover, the peak filling rate was inversely correlated (r = .57, p < .05) with the coefficient of variation of regional time to peak filling rate in the heart failure patients but not in the normal subjects.
  
  
  CONCLUSIONS
  These results suggest that left ventricular systolic and diastolic asynchrony may contribute to impair left ventricular systolic and diastolic function in patients with nonischemic heart failure.
authors.affiliation: Dipartimento di Scienze Radiologiche, Facoltà di Medicina, Università Federico II, Napoli.
authors.forename: A M
authors.initials: AM
authors.lastname: Della Morte
authors.forename: G
authors.initials: G
authors.lastname: Storto
authors.forename: A
authors.initials: A
authors.lastname: Varrone
authors.forename: L
authors.initials: L
authors.lastname: Pace
authors.forename: A
authors.initials: A
authors.lastname: Cuocolo
authors.forename: P
authors.initials: P
authors.lastname: Perrone-Filardi
authors.forename: S
authors.initials: S
authors.lastname: Betocchi
authors.forename: M
authors.initials: M
authors.lastname: Chiariello
authors.forename: M
authors.initials: M
authors.lastname: Salvatore
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D013997:Time Factors; D016277:Ventricular Function, Left
vernacular_title: Effetti dell'asincronia del ventricolo sinistro sulla funzione sistolica e diastolica nei pazienti con scompenso cardiaco con origine non ischemica.