[Molecular basis of renal development].
The first step of renal development is characterized by the invasion of a mesenchymal tissue, the metanephric blastema, by an epithelial structure, the ureter bud. Reciprocal inductive interactions between these two tissues, involving the sequential activation of genes that begin to be identified, are required for the successive stages of kidney morphogenesis. Recent technological advances such as gene targeting and improvement of organotypic culture have revealed the role of these genes and of several essential factors in kidney development. This review will focus on the genes which govern renal organogenesis, with special emphasis on those coding transcription and diffusible factors.
Lelongt
B
B
Hôpital Tenon, INSERM U 489, Paris. brigitte.lelongt@tnn.ap-hop-paris.fr
Legallicier
B
B
Ronco
P
P
D000818:Animals; D017209:Apoptosis / Q000235:genetics; D005796:Genes / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000002:abnormalities / Q000196:embryology*; D011519:Proto-Oncogenes / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics; D014513:Ureter / Q000196:embryology*
D014157:Transcription Factors
Bases moléculaires du développement rénal.