Inhibition of lymphoproliferative response and its restoration with a glucan immunomodulator in mice with experimental larval toxocarosis.
A high infective dose of Taxocara canis eggs (2,500 eggs per mouse) induced a partial immunosuppression in mice, manifested by inhibition of the proliferative response of splenic T and B cells to polyclonal activators. A glucan immunomodulator given to infected animals at the beginning of the experiment showed a marked stimulative and restorative effect on the parasite-suppressed lymphoproliferative response. The ability of T. canis to migrate in the host was reduced in glucan-treated animals by 27%.
Borosková
Z
Z
Parasitological Institute, Slovak, Kosice, Slovakia.
Reiterová
K
K
Dubinský
P
P
Tomasovicová
O
O
Machnicka
B
B
D000276:Adjuvants, Immunologic; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D005936:Glucans / Q000276:immunology / Q000494:pharmacology*; D007108:Immune Tolerance; D007814:Larva / Q000276:immunology; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D008934:Mitogens / Q000494:pharmacology; D010835:Phytohemagglutinins / Q000494:pharmacology; D013601:T-Lymphocytes / Q000276:immunology; D017166:Toxocara canis / Q000276:immunology* / Q000502:physiology; D014120:Toxocariasis / Q000276:immunology* / Q000469:parasitology; D047071:beta-Glucans
D000276:Adjuvants, Immunologic; D005936:Glucans; D008934:Mitogens; D010835:Phytohemagglutinins; D047071:beta-Glucans; C033363:beta-1,3-glucan