Presentation of bacterial lipid antigens by CD1 molecules.
Human CD1 molecules bind and display or present lipid and glycolipid antigens from mycobacteria for recognition by T cells. Presentation requires uptake of antigen into endosomes, where it binds to CD1. T-cell recognition of CD1-presented nonpeptide antigens is a newly defined immune response that could be important for host defense against a variety of pathogens.
Prigozy
T I
TI
La Jolla Institute for Allergy & Immunology, San Diego, CA 92121, USA.
Kronenberg
M
M
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D000942:Antigens, Bacterial / Q000276:immunology*; D018949:Antigens, CD1 / Q000276:immunology*; D011992:Endosomes; D006017:Glycolipids / Q000276:immunology*; D006801:Humans; D008055:Lipids / Q000276:immunology*; D009161:Mycobacterium / Q000276:immunology
D000942:Antigens, Bacterial; D018949:Antigens, CD1; D006017:Glycolipids; D008055:Lipids