title: A pathological study of experimental long-standing Schistosoma bovis infection in sheep.
abstract: The pathological response of sheep to two dose levels (400 or 10,000 cercariae) of Schistosoma bovis was evaluated 24 weeks after infection. The results confirmed that a single low or high dose causes lesions in the liver and intestine, and that the lungs, lymph nodes, pancreas and abomasum are affected in sheep given a single high dose. In addition, the study showed that pathological changes (mainly a granulomatous inflammatory reaction) were induced not only by eggs but also by adult worms, and that their severity was in general related to the dose of S. bovis. Hoeppli reaction product, observed on the surface of adult schistosomes in some parasitic granulomas, showed no immunoreaction for IgG, IgA or IgM.
authors.affiliation: Departamento de Patología Animal, Medicina Animal, Facultad de Veterinaria, Universidad de León, Spain.
authors.forename: M C
authors.initials: MC
authors.lastname: Ferreras-Estrada
authors.forename: M J
authors.initials: MJ
authors.lastname: García-Iglesias
authors.forename: C
authors.initials: C
authors.lastname: Pérez-Martínez
authors.forename: M Y
authors.initials: MY
authors.lastname: Manga-González
authors.forename: V
authors.initials: V
authors.lastname: Ramajo-Martín
authors.forename: A
authors.initials: A
authors.lastname: Escudero-Diez
authors.forename: J F
authors.initials: JF
authors.lastname: García-Marín
mesh_terms: D000818:Animals; D003106:Colon / Q000469:parasitology / Q000473:pathology; D004386:Duodenum / Q000469:parasitology / Q000473:pathology; D006099:Granuloma / Q000473:pathology; D007583:Jejunum / Q000469:parasitology / Q000473:pathology; D008099:Liver / Q000469:parasitology / Q000473:pathology; D008168:Lung / Q000469:parasitology / Q000473:pathology; D010063:Ovum / Q000276:immunology; D012547:Schistosoma / Q000472:pathogenicity*; D012552:Schistosomiasis / Q000473:pathology / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000469:parasitology / Q000473:pathology*