Protein and lipid sorting from the trans-Golgi network to the plasma membrane in polarized cells.
The targeting of proteins and lipids to the cell surface domains of polarized cells is not a simple bulk flow process but requires sorting into distinct apical and basolateral pathways from the trans-Golgi network. Here, we describe the sorting determinants in the cargo molecules, the cellular sorting machineries responsible for the hierarchical read-out of the signals, and the mechanisms of cargo delivery. Furthermore, we discuss the implications of these findings for protein-lipid interactions in other cellular machineries.
Ikonen
E
E
Department of Biochemistry, National Public Health Institute, Mannerheimintie 166, Helsinki, 00300, Finland.
Simons
K
K
D000818:Animals; D001692:Biological Transport / Q000502:physiology*; D002462:Cell Membrane / Q000378:metabolism*; D016764:Cell Polarity; D002784:Cholesterol / Q000502:physiology; D005057:Eukaryotic Cells / Q000502:physiology* / Q000648:ultrastructure; D006028:Glycosphingolipids / Q000502:physiology; D006801:Humans; D007425:Intracellular Membranes / Q000502:physiology; D008051:Lipid Bilayers; D008561:Membrane Fusion; D008563:Membrane Lipids / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D008954:Models, Biological; D011134:Polysaccharides / Q000502:physiology; D021382:Protein Sorting Signals / Q000502:physiology
D006028:Glycosphingolipids; D008051:Lipid Bilayers; D008563:Membrane Lipids; D008565:Membrane Proteins; D011134:Polysaccharides; D021382:Protein Sorting Signals; D002784:Cholesterol