Expression of adhesion molecule CD44 in metastatic brain tumors.
Expression of CD44 (m.w. 80-95 kD) in 48 metastatic brain tumors was examined using monoclonal antibody on paraffin sections. The CD44 expression was found in 48% of studied tumors. The most constant expression of CD44 was observed in metastases from thyroid, skin and breast cancer. The brain metastases were characterized by quite heterogenous distribution of CD44 glycoprotein--the most pronounced expression was seen in individual neoplastic cells embedded in abundant stroma and in the vicinity of preserved neural tissue. Such a topographical distribution of CD44 supports its role in interactions of cancer cells with extracellular matrix components of the tumor stroma as well as of neural tissue.
Harabin-Słowińska
M
M
Department of Histology and Embryology, Silesian School of Medicine, Zabrze.
Słowiński
J
J
Konecki
J
J
Mrówka
R
R
D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism / Q000556:secondary*; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000276:immunology; D001932:Brain Neoplasms / Q000235:genetics / Q000378:metabolism / Q000556:secondary*; D001943:Breast Neoplasms / Q000473:pathology; D002448:Cell Adhesion; D003110:Colonic Neoplasms / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005909:Glioblastoma / Q000235:genetics / Q000378:metabolism / Q000556:secondary; D006801:Humans; D018960:Hyaluronan Receptors / Q000096:biosynthesis* / Q000235:genetics / Q000276:immunology; D008297:Male; D008545:Melanoma / Q000235:genetics / Q000378:metabolism / Q000556:secondary*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics / Q000276:immunology; D012878:Skin Neoplasms / Q000473:pathology; D013964:Thyroid Neoplasms / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000473:pathology
D000911:Antibodies, Monoclonal; D018960:Hyaluronan Receptors; D009363:Neoplasm Proteins