New secosteroids from a gorgonian of the genus Muricella.
Calicoferols F-I (2-5), four new 9,10-secosteroids, have been isolated from a gorgonian of the genus Muricella collected from Jaeju Island, Korea. The structures of these compounds have been determined by combined spectroscopic methods. Calicoferols exhibited significant cytotoxicity and inhibitory activity against PLA2.
Seo
Y
Y
Marine Natural Products Laboratory and Polar Research Center, Korea Ocean Research & Development Institute, Ansan P.O. Box 29, Seoul 425-600, Korea.
Cho
K W
KW
Chung
H
H
Lee
H S
HS
Shin
J
J
D000818:Animals; D003063:Cnidaria / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D007723:Korea; D009682:Magnetic Resonance Spectroscopy; D010741:Phospholipases A / Q000037:antagonists & inhibitors; D054467:Phospholipases A2; D012632:Secosteroids / Q000302:isolation & purification* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D012632:Secosteroids; D010741:Phospholipases A; D054467:Phospholipases A2