Quanolirones I and II, two new human cytomegalovirus protease inhibitors produced by Streptomyces sp. WC76535.
Two new naphthacenequinone glycosides, quanolirones I (1) and II (2) were isolated, together with the known compound galtamycin from the fermentation broth of Streptomyces sp. WC76535. The structures 1 and 2 were established by analysis of their spectroscopic data and by comparison of their data to those of galtamycin. Compounds 1, 2, and galtamycin showed inhibitory activity against HCMV protease with IC50 values of 14, 35, and 52 microM, respectively.
Qian-Cutrone
J
J
Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, Connecticut 06492, USA.
Kolb
J M
JM
McBrien
K
K
Huang
S
S
Gustavson
D
D
Lowe
S E
SE
Manly
S P
SP
D002240:Carbohydrate Sequence; D002851:Chromatography, High Pressure Liquid; D003470:Culture Media; D003587:Cytomegalovirus / Q000201:enzymology; D005285:Fermentation; D006027:Glycosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D009279:Naphthacenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011480:Protease Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D012697:Serine Endopeptidases / Q000378:metabolism*; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000378:metabolism*
D003470:Culture Media; D006027:Glycosides; D009279:Naphthacenes; D011480:Protease Inhibitors; C117177:quanolirone I; C117178:quanolirone II; D012697:Serine Endopeptidases; C071910:assemblin