title: Parameters of lymphocyte Na+-Ca2+ regulation and blood pressure: the gender effect.
abstract: Alterations in cellular Ca2+ and Na+ regulation play a role in the pathogenesis of essential hypertension. Using peripheral lymphocytes from 68 normal persons, we observed the following relationships for major cellular Ca2+ regulatory parameters. Among men and women, Na+-Ca2+ exchanger activity was positively correlated with the resting cytosolic free Ca2+ ([Ca2+]c) (r=0.43, P=0.0003), and the resting [Ca2+]c was positively correlated with cytosolic Na+ ([Na+]c) (r=0.50, P=0.0001). For men only, store-operated Ca2+ entry was positively correlated with Na+-Ca2+ exchanger activity (r=0.63, P=0.0001). In addition, systolic and diastolic blood pressures were positively correlated with [Na+]c in men (r=0.53, P=0.001, and r=0. 41, P=0.017, respectively) but not in women (r=0.30, P=0.088, and r=0.24, P=0.17, respectively). Some of the relationships between cellular and blood pressure parameters were confounded by serum triglycerides. These observations indicate a gender effect on cellular Ca2+-Na+ regulation and its relationship with blood pressure.
authors.affiliation: Hypertension Research Center and the Department of Preventive Medicine and Community Health, University of Medicine and Dentistry of NJ, New Jersey Medical School, Newark, NJ, USA.
authors.forename: M
authors.initials: M
authors.lastname: Horiguchi
authors.forename: M
authors.initials: M
authors.lastname: Kimura
authors.forename: J
authors.initials: J
authors.lastname: Skurnick
authors.forename: A
authors.initials: A
authors.lastname: Aviv
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D002118:Calcium / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D012737:Sex Factors; D012964:Sodium / Q000378:metabolism*; D019831:Sodium-Calcium Exchanger / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood
chemical_list: D019831:Sodium-Calcium Exchanger; D014280:Triglycerides; D012964:Sodium; D002118:Calcium