title: Comparison of the efficacy of apraclonidine and brimonidine as aqueous suppressants in humans.
abstract: OBJECTIVE
  To measure and compare the effect of apraclonidine hydrochloride and brimonidine tartrate on the rate of aqueous humor flow in human subjects.
  
  
  METHODS
  Forty normal human subjects were given apraclonidine or brimonidine by topical instillation. Aqueous humor flow was measured by the rate of disappearance of topically applied fluorescein. Intraocular pressure was measured by applanation tonometry.
  
  
  RESULTS
  Apraclonidine suppressed aqueous humor flow between 39% and 44% and lowered intraocular pressure between 20% and 23%. Brimonidine suppressed aqueous humor flow between 44% and 48% and lowered intraocular pressure between 19% and 22%.
  
  
  CONCLUSIONS
  No statistically significant differences were found between the effects of the 2 drugs on aqueous humor dynamics in normal subjects.
authors.affiliation: Department of Ophthalmology, Mayo Clinic, Rochester, Minn., USA.
authors.forename: R
authors.initials: R
authors.lastname: Schadlu
authors.forename: T L
authors.initials: TL
authors.lastname: Maus
authors.forename: C B
authors.initials: CB
authors.lastname: Nau
authors.forename: R F
authors.initials: RF
authors.lastname: Brubaker
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D000328:Adult; D001082:Aqueous Humor / Q000187:drug effects* / Q000378:metabolism; D000068438:Brimonidine Tartrate; D003000:Clonidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D015590:Fluorophotometry; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D009883:Ophthalmic Solutions; D011810:Quinoxalines / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D014065:Tonometry, Ocular
chemical_list: D000316:Adrenergic alpha-Agonists; D009883:Ophthalmic Solutions; D011810:Quinoxalines; D000068438:Brimonidine Tartrate; C016986:apraclonidine; D003000:Clonidine