Dual D2-receptor and beta2-adrenoceptor agonists for the treatment of airway diseases. 1. Discovery and biological evaluation of some 7-(2-aminoethyl)-4-hydroxybenzothiazol-2(3H)-one analogues.
Bonnert
R V
RV
Astra Charnwood, Bakewell Road, Loughborough, Leicestershire LE11 5RH, UK.
Brown
R C
RC
Chapman
D
D
Cheshire
D R
DR
Dixon
J
J
Ince
F
F
Kinchin
E C
EC
Lyons
A J
AJ
Davis
A M
AM
Hallam
C
C
Harper
S T
ST
Unitt
J F
JF
Dougall
I G
IG
Jackson
D M
DM
McKechnie
K
K
Young
A
A
Simpson
W T
WT
D058666:Adrenergic beta-2 Receptor Agonists; D000318:Adrenergic beta-Agonists / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D016084:Bronchoconstriction / Q000187:drug effects; D004285:Dogs; D018491:Dopamine Agonists / Q000138:chemical synthesis* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004423:Ear / Q000098:blood supply; D066298:In Vitro Techniques; D008173:Lung Diseases, Obstructive / Q000188:drug therapy*; D009093:Mucus / Q000187:drug effects; D011817:Rabbits; D017448:Receptors, Dopamine D2 / Q000819:agonists*; D012119:Respiration / Q000187:drug effects; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D014661:Vasoconstriction / Q000187:drug effects
D058666:Adrenergic beta-2 Receptor Agonists; D000318:Adrenergic beta-Agonists; D018927:Anti-Asthmatic Agents; D018491:Dopamine Agonists; D017448:Receptors, Dopamine D2; D013844:Thiazoles; C116267:sibenadet