title: Rapid detection of dihydrocodeine by thermospray mass spectrometry.
abstract: Rapid assay of dihydrocodeine (DHC) by thermospray mass spectrometry is explored. Liquid-liquid extractions of blood, urine and gastric contents were injected into a thermospray mass spectrometer, to which there was no column connected, and DHC was assayed by the flow injection method. The mass spectra of DHC under thermospray ionization and filament-on ionization modes consist of the MH+ ion of mlz 302 alone, which was clearly detected in the samples. Although DHC should be quantitated by gas chromatography-mass spectrometry, this method is applicable for rapid identification of DHC in biological materials.
authors.affiliation: Department of Legal Medicine, Kansai Medical University, Moriguchi, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
authors.forename: A
authors.initials: A
authors.lastname: Akane
authors.forename: Y
authors.initials: Y
authors.lastname: Okii
authors.forename: S
authors.initials: S
authors.lastname: Yoshimura
authors.forename: T
authors.initials: T
authors.lastname: Tokiyasu
authors.forename: T
authors.initials: T
authors.lastname: Watabiki
mesh_terms: D003061:Codeine / Q000031:analogs & derivatives* / Q000032:analysis; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods*
chemical_list: C014481:dihydrocodeine; D003061:Codeine