title: [Effect of various forms of metastatic lymph node involvement on prognosis of squamous epithelial carcinomas of the upper aerodigestive tract].
abstract: BACKGROUND
  Based on a new histo-morphological rating scheme, we assessed the impact on patient prognosis of lymph node metastasis of squamous cell carcinoma (SCC) in the head/neck area. Special attention was given to possible capsular rupture.
  
  
  METHODS
  In a retrospective study, 111 patients with squamous cell carcinoma of the head and neck with concomitant cervical lymph node metastases were evaluated to determine the importance of lymph node capsular rupture on the occurrence of disseminated disease, loco-regional recurrence as well as survival rate. To cover the broad morphological spectrum of cervical metastatic disease, a newly developed scheme (differentiating seven different histo-morphological types of lymph node metastasis) was applied. On the basis of this scheme, every single metastatic lymph node received a score from one to seven. These single scores were then added to obtain a total score for every individual patient. These total scores were then divided into four groups.
  
  
  RESULTS
  Synthesis of histo-morphological pattern of metastasis in combination with the number of metastatic lymph nodes showed highest concordance/significance in respect of disseminated disease (p = 0.0029), local recurrence (p = 0.0008) and regional lymph node metastasis (p = 0.0000) as well as survival rate (p = 0.0000).
  
  
  CONCLUSIONS
  The newly introduced histological scheme seems to provide more accuiate and detailed information on the prognosis of SCC in the head and neck area.
authors.affiliation: Hals-Nasen-Ohrenklinik des Universitätskrankenhauses Hamburg-Eppendorf.
authors.forename: W
authors.initials: W
authors.lastname: Kehrl
authors.forename: S
authors.initials: S
authors.lastname: Wenzel
authors.forename: A
authors.initials: A
authors.lastname: Niendorf
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D009367:Neoplasm Staging; D010039:Otorhinolaryngologic Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D011379:Prognosis; D015996:Survival Rate
vernacular_title: Einfluss verschiedener Formen des metastatischen Lymphknotenbefalls auf die Prognose von Plattenepithelkarzinomen im oberen Aerodigestivtrakt.