title: Acute effects of nicotine content in cigarettes on coronary flow velocity and coronary flow reserve in men.
abstract: We investigated the acute effects of smoking on coronary flow reserve in terms of the nicotine content of cigarettes in 21 smokers. Coronary flow velocity was measured with a Doppler flow wire. Subjects smoked cigarettes containing >1 mg nicotine (n = 8, group 1) or <1 mg (n = 6, group 2). Subjects in the control group mimicked smoking without a cigarette (n = 7). Coronary flow reserve decreased after smoking in group 1, but not in group 2 or the control group. This reduction may have mediated nicotine or some other unknown substances influenced by smoking.
authors.affiliation: Department of Cardiology, Showa General Hospital, Kodaira-City, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Oka
authors.forename: I
authors.initials: I
authors.lastname: Tawara
authors.forename: T
authors.initials: T
authors.lastname: Sada
authors.forename: Y
authors.initials: Y
authors.lastname: Kira
mesh_terms: D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D003326:Coronary Circulation / Q000187:drug effects*; D004837:Epinephrine / Q000097:blood; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009538:Nicotine / Q000097:blood / Q000494:pharmacology*; D009638:Norepinephrine / Q000097:blood; D012907:Smoking; D013566:Sympathomimetics / Q000097:blood
chemical_list: D013566:Sympathomimetics; D009538:Nicotine; D009638:Norepinephrine; D004837:Epinephrine