Hyaluronidase as additive to induction chemotherapy in advanced squamous cell carcinoma of the head and neck.
Forty-eight patients with advanced head and neck tumours were treated with irradiation and concomitant chemotherapy with cisplatin, vindesine and hyaluronidase. The disease-free survival rate at 5 years was 47%. The toxic effects were mucositis (48 patients), nausea (25 patients, vomiting in six patients), bone marrow depression (15 patients) and peripheral neuropathy (14 patients). The results warrant a randomized trial.
Klocker
J
J
1st Medical Department, Institute of Oncology, Klagenfurt General Hospital, Austria.
Sabitzer
H
H
Raunik
W
W
Wieser
S
S
Schumer
J
J
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy; D002945:Cisplatin / Q000008:administration & dosage; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000008:administration & dosage; D015996:Survival Rate; D014751:Vindesine / Q000008:administration & dosage
D006821:Hyaluronoglucosaminidase; D002945:Cisplatin; D014751:Vindesine