[The level of endogenous prostaglandins in adolescents with duodenal peptic ulcer in relation to the phase of the disease].
Sixty-seven adolescents suffering from duodenal ulcer (DU) were studied for the level of prostaglandins (PG) E and P2 alpha in the gastric juice and blood plasma depending on the condition of the gastric juice hydrochloric acid secretion and phase of the disease. There were no significant differences in PG content in adolescents with hyper- and normal acidity or subacidity. During the stage of aggravation PG level gets significantly increased and remains somewhat elevated during remission. We suggest that in DU adolescents there is a relative deficiency of endogenous PG that affects resistance of gastric and duodenal mucosa, which event might promote ulceration even with normal secretion of gastric juice. These considerations should be taken account of in conducting a therapy.
Isakova
M Iu
MIu
D000293:Adolescent; D002908:Chronic Disease; D015237:Dinoprost / Q000032:analysis*; D004381:Duodenal Ulcer / Q000378:metabolism*; D005260:Female; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000737:chemistry; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D008297:Male; D011458:Prostaglandins E / Q000032:analysis*
D011458:Prostaglandins E; D015237:Dinoprost
Soderzhanie éndogennykh prostaglandinov u podrostkov, bol'nykh iazvennoĭ bolezn'iu dvenadtsatiperstnoĭ kishki, v zavisimosti ot fazy zabolevaniia.