title: Cytotoxic and leishmanicidal aminoglycosteroids and aminosteroids from Holarrhena curtisii.
abstract: The EtOH extract of the leaves of Holarrhena curtisii yielded five new steroidal alkaloids: 17-epi-holacurtine (3), 17-epi-N-demethylholacurtine (4), holacurtinol (5), 3alpha-amino-14beta-hydroxypregnan-20-one (7), and 15alpha-hydroxyholamine (8), in addition to the known compounds, holacurtine (1), N-demethylholacurtine (2), and holamine (6). All eight compounds showed significant cytotoxic and leishmanicidal activities.
authors.affiliation: Department of Chemistry, University of Malaya, 59100 Kuala Lumpur, Malaysia. tskam@kimia.um.edu.my
authors.forename: T S
authors.initials: TS
authors.lastname: Kam
authors.forename: K M
authors.initials: KM
authors.lastname: Sim
authors.forename: T
authors.initials: T
authors.lastname: Koyano
authors.forename: M
authors.initials: M
authors.lastname: Toyoshima
authors.forename: M
authors.initials: M
authors.lastname: Hayashi
authors.forename: K
authors.initials: K
authors.lastname: Komiyama
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D007893:Leishmania donovani / Q000187:drug effects*; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D013256:Steroids / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D000981:Antiprotozoal Agents; D013256:Steroids