Effects of gestational exposure to a video display terminal-like magnetic field (20-kHz) on CBA/S mice.
Possible adverse effects of magnetic fields (MFs) on reproduction have been an open question. To verify the embryo-lethal effect of pulsed MF of the type emitted by video display terminals (VDTs) reported previously in CBA/S mice, a developmental toxicity study was conducted in animals of the same origin. Mated CBA/S mice (80-86 pregnant animals per group) were exposed to a 20-kHz MF with sawtooth waveform continuously from gestational day 0-18. The flux density of the vertical MF was 15 microT peak-to-peak (150 mG). This field was previously reported to increase the number of resorptions in CBA/S mice. On gestational day 18, the dams were killed and blood and bone marrow samples were taken for hematology and micronuclei analysis, respectively. The number of corpora lutea was counted and the content of the uterus examined. There were no statistically significant differences in maternal or fetal body weights, number of corpora lutea, implantations, resorptions, dead and live fetuses, or external and skeletal malformations. MF did not alter the number of blood cells or cause micronuclei in bone marrow erythrocytes in the dams. The mean number of resorptions was slightly but not statistically significantly, higher in the MF group than in controls. The results do not indicate marked developmental, hematological, or clastogenic effects of 20-kHz MFs.
Huuskonen
H
H
Laboratory of Toxicology, National Public Health Institute, Kuopio, Finland. Hannele.Huuskonen@ktl.fi
Juutilainen
J
J
Julkunen
A
A
Mäki-Paakkanen
J
J
Komulainen
H
H
D000016:Abnormalities, Radiation-Induced / Q000209:etiology*; D000818:Animals; D001773:Blood Cells / Q000528:radiation effects; D001835:Body Weight / Q000528:radiation effects; D016288:Computer Terminals; D004574:Electromagnetic Fields / Q000009:adverse effects*; D005260:Female; D051379:Mice; D008808:Mice, Inbred CBA; D011247:Pregnancy; D011829:Radiation Dosage; D012098:Reproduction / Q000528:radiation effects*