The influence of HLB on the encapsulation of oils by complex coacervation.
Microcapsules are used for the formulation of drug controlled release and drug targeting dosage forms. Encapsulated hydrophobic drugs are often applied as their solutions in plant oils. The uptake of the oils in the complex coacervate microcapsules can be improved by the addition of surfactants. In this study, soybean, olive and peanut oils were chosen as the representatives of plant oils. The well characterized complex coacervation of gelatin and acacia has been used to produce the microcapsules. The amount of encapsulated oil has been determined gravimetrically. The encapsulation of the oils was high (75-80%). When the surfactants with HLB values from 1.8 to 6.7 were used, the amount of encapsulated oil was high (65-85%). A significant decrease of the oil content in the microcapsules was found when Tween 61 with HLB = 9.6 had been added into the mixture. No oil was found inside the microcapsules from the coacervate emulsion mixture containing Tween 81 (HLB = 10) and Tween 80 (HLB = 15), respectively. The results of the experiment confirm the dependence of hydrophobic substance encapsulation on the HLB published recently for Squalan.
Rabisková
M
M
The Department of Pharmaceutics, Faculty of Pharmacy, The University of Veterinary and Pharmaceutical Sciences, Brno, The Czech Republic.
Valásková
J
J
D000045:Acacia / Q000737:chemistry; D002214:Capsules; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002627:Chemistry, Physical; D003692:Delayed-Action Preparations; D004355:Drug Stability; D004655:Emulsions; D005079:Excipients / Q000737:chemistry; D005780:Gelatin / Q000737:chemistry; D010938:Plant Oils / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry
D002214:Capsules; D003692:Delayed-Action Preparations; D004655:Emulsions; D005079:Excipients; D010938:Plant Oils; D013501:Surface-Active Agents; D005780:Gelatin