title: Human fecal PCDD/F-excretion exceeds the dietary intake.
abstract: A mass balance of human dietary PCDD/F-intake and fecal PCDD/F-excretion was carried out. The participants of the study were seven male and seven female adults between the ages of 24 to 64 years, living in North Rhine-Westphalia, Germany. The PCDD/F-intake was measured using the duplicate method. Sampling time of each food duplicate covered three days. The fecal PCDD/F-excretion was measured by collecting the feces which corresponded to the food duplicates. The mean daily dietary PCDD/F-intake was 49 pg I-TEq/d (range: 23-96 pg I-TEq/d) and therewith lower than that estimated in the past. The mean daily fecal PCDD/F-excretion was 98 pg I-TEq/d (40-200 pg I-TEq/d). This is twice the amount of the PCDD/F-intake. The fecal excretion of OCDD was especially higher than the dietary intake (mean: 7 fold, range: 1.2-21 fold). The differences between PCDD/F-intake and PCDD/F-excretion may be caused by a reduction of the body burden as a consequence of decreasing PCDD/F-intake. Other explanations were additional sources of exposure to PCDD/F or de novo formation of PCDD/F in the human body.
authors.affiliation: Ruhr-Universität Bochum, Institut für Hygiene, Sozial- und Umweltmedizin, Germany. schrey@hygiene.ruhr-uni-bochum.de
authors.forename: P
authors.initials: P
authors.lastname: Schrey
authors.forename: J
authors.initials: J
authors.lastname: Wittsiepe
authors.forename: P
authors.initials: P
authors.lastname: Mackrodt
authors.forename: F
authors.initials: F
authors.lastname: Selenka
mesh_terms: D000328:Adult; D001572:Benzofurans / Q000493:pharmacokinetics*; D001822:Body Burden; D004032:Diet; D004781:Environmental Exposure; D005243:Feces / Q000737:chemistry; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
chemical_list: D001572:Benzofurans; D000072317:Polychlorinated Dibenzodioxins