title: Development of a scheme for genotyping Helicobacter pylori based on allelic variation in urease subunit genes.
abstract: Helicobacter pylori urease subunit genes in 383 isolates from 10 countries were investigated by PCR-restriction fragment length polymorphism (HaeIII) analysis. Eighty-two different ureAB profiles were documented by reference to known sequences. Variation among 51% of strains was accounted for by 10 predominant patterns, which provided a unique framework for categorizing isolates with geographically diverse origins.
authors.affiliation: Laboratory of Enteric Pathogens, Central Public Health Laboratory, London, United Kingdom. rowen@phls.co.uk
authors.forename: R J
authors.initials: RJ
authors.lastname: Owen
authors.forename: E R
authors.initials: ER
authors.lastname: Slater
authors.forename: J
authors.initials: J
authors.lastname: Xerry
authors.forename: T M
authors.initials: TM
authors.lastname: Peters
authors.forename: E L
authors.initials: EL
authors.lastname: Teare
authors.forename: A
authors.initials: A
authors.lastname: Grant
mesh_terms: D000483:Alleles; D005798:Genes, Bacterial; D014644:Genetic Variation; D005838:Genotype; D016480:Helicobacter pylori / Q000145:classification* / Q000235:genetics; D006801:Humans; D012150:Polymorphism, Restriction Fragment Length; D014510:Urease / Q000235:genetics*
chemical_list: D014510:Urease