title: Thrombophilia and activated protein C resistance.
abstract: In addition to classic vascular insults such as inflammation, trauma, malignancy, and surgery, a number of hereditary coagulation defects predispose patients to a wide array of thrombotic complications. A novel genetic defect in factor V allowing for resistance to its cleavage by activated protein C has recently been implicated in a significant number of cases of familial thrombophilia. A brief case report and review of the literature is presented to familiarize surgeons to this important and quite frequent cause of hypercoagulability.
authors.affiliation: Section of Vascular Surgery, University of Colorado Health Sciences Center, Denver, CO, USA.
authors.forename: C H
authors.initials: CH
authors.lastname: Selzman
authors.forename: T A
authors.initials: TA
authors.lastname: Whitehill
authors.forename: W C
authors.initials: WC
authors.lastname: Krupski
mesh_terms: D020016:Activated Protein C Resistance / Q000150:complications* / Q000235:genetics; D000293:Adolescent; D006801:Humans; D008297:Male; D019851:Thrombophilia / Q000209:etiology*; D020246:Venous Thrombosis / Q000209:etiology*