Serum beta-endorphin levels in morbidly obese patients: the effect of vertical banded gastroplasty.
The associations between serum beta-endorphin levels and clinical and metabolic variables as well as beta-endorphin changes after surgically induced weight loss were investigated in 43 morbidly obese patients. A significant positive correlation between beta-endorphin and body weight, degree of body weight increase and ACTH was found preoperatively. Only body weight was independently associated with beta-endorphin levels. Twelve months following vertical banded gastroplasty, there was an extensive weight loss in all patients and improvement in their metabolic profile. A significant reduction in beta-endorphin levels which was proportional to the extent of weight loss was also observed.
Karayiannakis
A J
AJ
First Department of Surgery, University of Athens, Laikon Hospital, Athens, Greece.
Zbar
A
A
Makri
G G
GG
Syrigos
K
K
Athanasiadis
L
L
Alexiou
D
D
Bastounis
E A
EA
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D005260:Female; D015391:Gastroplasty / Q000379:methods*; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D009767:Obesity, Morbid / Q000097:blood* / Q000473:pathology / Q000601:surgery*; D013997:Time Factors; D015431:Weight Loss; D001615:beta-Endorphin / Q000097:blood*
D008055:Lipids; D001615:beta-Endorphin; D000324:Adrenocorticotropic Hormone