Description of a new DRB1*11 allele (DRB1*1132).
We describe a new DRB1*11 allele which is similar to DRB1*11011 except at codon 74, where a GCG is changed for a GTG leading to an alanine/valine substitution. This new allele was carried by a Caucasian patient suffering from rheumatoid arthritis and by her healthy daughter. The motif at codon 74 of the new DRB1*11 is not found in any other known DRB alleles, nor among the published DQA1, DQB1, DPA1 or DPB1 alleles, and therefore suggests a mechanism of point mutation.
Loiseau
P
P
Hôpital Saint-Louis, Laboratoire d'Immunologie et d'Histocompatibilité, Paris, France.
Loste
M N
MN
Lepage
V
V
Schaeffer
V
V
Lethielleux
P
P
Tilanus
M
M
van Der Zwan
A W
AW
Dubel
L
L
Nigou
M
M
Johanet
C
C
Charron
D
D
D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000235:genetics; D001483:Base Sequence; D003062:Codon; D005260:Female; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006239:Haplotypes; D006801:Humans; D008969:Molecular Sequence Data; D017354:Point Mutation; D012150:Polymorphism, Restriction Fragment Length
D003062:Codon; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C553518:HLA-DRB1*11:01:01 antigen