Case-control study on the role of heterocyclic amines in the etiology of upper aerodigestive cancers in Uruguay.
To examine the risk of upper aerodigestive tract cancers (UADC: oral cavity, pharynx, larynx, and esophagus) associated with dietary heterocyclic amine (HCA) exposure, a case-control study involving 140 cases and 286 controls was conducted in Montevideo, Uruguay. Beef and red meat intakes were positively associated with risk of UADC [odds ratio (OR) for red meat intake = 2.8, 95% confidence interval (CI) = 1.4-6.0], whereas no association was observed with white meat (poultry plus fish) intake. When meat intake was examined by cooking method, no association was observed for fried meat. On the other hand, broiled and boiled meat were associated with a significant increase in risk of UADC (OR for broiled meat = 2.0, 95% CI = 1.0-4.3). Total HCA intake was associated with an increased risk (OR = 2.2, 95% CI = 1.1-4.2) of UADC. The HCA effect was similar among the different cancer sites.
De Stefani
E
E
Registro Nacional de Cancer, Montevideo, Uruguay.
Ronco
A
A
Mendilaharsu
M
M
Deneo-Pellegrini
H
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000588:Amines / Q000009:adverse effects*; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced*; D016022:Case-Control Studies; D004067:Digestive System Neoplasms / Q000139:chemically induced*; D005260:Female; D005506:Food Contamination; D006571:Heterocyclic Compounds / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008460:Meat; D008875:Middle Aged; D012142:Respiratory Tract Neoplasms / Q000139:chemically induced*; D011795:Surveys and Questionnaires; D014583:Uruguay
D000588:Amines; D006571:Heterocyclic Compounds