title: Interventional nutrition for gastrointestinal disease.
abstract: Nutritional intervention plays a key role in the successful management of gastrointestinal disease. This article focuses on several novel areas of nutritional intervention that are becoming increasingly important in gastrointestinal disease, including short-chain fatty acids, omega-3 polyunsaturated fatty acids and glutamine. Short-chain fatty acids are the principal end-products of bacterial fermentation of dietary fibers and have profound effects on normal intestinal cell metabolism and proliferation. Short-chain fatty acids have the potential to improve overall intestinal health, stimulate intestinal healing, and decrease intestinal inflammation. Omega-3 fatty acids, from dietary sources or supplements, may also be useful in decreasing intestinal inflammation and in preventing intestinal cancer. Finally, glutamine also may play an important role in the nutritional management of gastrointestinal disease.
authors.affiliation: Central Research Division, Pfizer Inc., Groton, CT 06340, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Hickman
mesh_terms: D000818:Animals; D000829:Animals, Domestic; D002371:Cat Diseases / Q000178:diet therapy / Q000378:metabolism; D002415:Cats; D004283:Dog Diseases / Q000178:diet therapy / Q000378:metabolism; D004285:Dogs; D005227:Fatty Acids / Q000378:metabolism / Q000627:therapeutic use; D015525:Fatty Acids, Omega-3 / Q000378:metabolism / Q000627:therapeutic use; D005767:Gastrointestinal Diseases / Q000178:diet therapy* / Q000378:metabolism / Q000662:veterinary*; D005973:Glutamine / Q000378:metabolism / Q000627:therapeutic use; D008322:Mammals / Q000378:metabolism
chemical_list: D005227:Fatty Acids; D015525:Fatty Acids, Omega-3; D005973:Glutamine