Renal involvement in Behçet's disease: review of 9 cases.
We describe clinical data on 9 patients with Behçet's disease with renal involvement (8 males, one female) and results of kidney biopsies in 4 patients. Renal involvement occurred in 9 of 120 patients (7.5%) followed at our center. Proteinuria was present in 8 patients (6 with quantitative 24 h urine protein with a range of 0.32-3.11 g/day, mean 1.7 g/day); hematuria occurred in one patient. Impaired renal function was encountered in 2 patients at presentation and in another patient at a later date. Major vascular involvement (major venous and/or arterial thrombosis) was present in 4 patients and sagittal sinus thrombosis in another patient. Measurement of complement C3, C4, and CH50 and immunologic tests for anticardiolipin, antineutrophil cytoplasmic, and antistreptococcal antibodies did not indicate a clear association with renal involvement. Kidney biopsies were performed in 4 patients. Mesangial proliferative changes were observed in 3 patients and evidence of immune complex deposition by immunofluorescence and electron microscopic examination was present in 2 patients. Amyloidosis was present in one patient who had vascular involvement and presented with nephrotic range proteinuria.
El Ramahi
K M
KM
Department of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Al Dalaan
A
A
Al Shaikh
A
A
Al Meshari
K
K
Akhtar
M
M
D000293:Adolescent; D000328:Adult; D000936:Antigen-Antibody Complex / Q000032:analysis; D001528:Behcet Syndrome / Q000150:complications* / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D001706:Biopsy; D005260:Female; D005455:Fluorescent Antibody Technique; D005920:Glomerular Mesangium / Q000473:pathology; D006417:Hematuria / Q000209:etiology; D006801:Humans; D007668:Kidney / Q000473:pathology / Q000503:physiopathology; D007674:Kidney Diseases / Q000209:etiology* / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D011507:Proteinuria / Q000209:etiology; D014652:Vascular Diseases / Q000209:etiology
D000936:Antigen-Antibody Complex