Effect of alpha,beta-arteether against primary amoebic meningoencephalitis in Swiss mice.
Artemisinin and its derivative alpha, beta-arteether have been evaluated for activity against experimental primary amoebic meningoencephalitis. In vivo experiments have shown that amphotericin B at dose of 2.5 mg/kg for 5 days produced 100% protection. Artemisinin and alpha, beta-arteether, even when tested at a high doses (60-120 mg/kg x 5 days and 90-180 mg/x 5 days) respectively, were not curative and showed only slight protection as indicated by extension of mean survival time.
Gupta
S
S
Centre Drug Research Institute, Lucknow, India.
Dutta
G P
GP
Vishwakarma
R A
RA
D000562:Amebiasis / Q000188:drug therapy* / Q000469:parasitology; D000563:Amebicides / Q000008:administration & dosage / Q000627:therapeutic use*; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use; D000818:Animals; D037621:Artemisinins; D008590:Meningoencephalitis / Q000188:drug therapy* / Q000469:parasitology; D051379:Mice; D016848:Naegleria fowleri / Q000302:isolation & purification; D012717:Sesquiterpenes / Q000008:administration & dosage / Q000627:therapeutic use*
D000563:Amebicides; D037621:Artemisinins; D012717:Sesquiterpenes; D000666:Amphotericin B; C031327:artemisinin; C055141:artemotil