title: Who suffers most from leg ulceration?
abstract: This study examines health-related quality of life (HRQoL) in patients with leg ulceration and determines which patient groups are affected most by this condition. A cross-sectional study using the Nottingham Health Profile (NHP) and age/sex-matched normal scores in patients entering six clinical audit cycles was carried out. The 758 patients included in the study (mean age 74.6 years, 64% women) had been affected by leg ulceration for a median of 10.5 months (range 0.5 to 708). Patients produced significantly higher scores than age/sex-matched normal values for all domains of the NHP, indicating poorer HRQoL (all p < 0.001). Increasing age led to greater deficits in energy (p < 0.001) and mobility (p < 0.001) with greater social isolation (p = 0.044). Women experienced poorer energy, sleep patterns, mobility and emotional reactions (all p < 0.001), and increased physical pain and social isolation (p < 0.05) compared to men. However, higher scores may be expected for older women based on age/sex-matched normal values. After adjustment for age/sex-matched normal values, it was the younger patients who experienced a greater deficit in HRQoL over all domains of the NHP, with men scoring higher than women in the domains of bodily pain, sleep and social isolation (p < 0.001) and energy (p = 0.015). Leg ulceration has a major impact on patients' HRQoL as detected by the NHP. The excess in scores compared with age/sex-matched normal values indicate that it is younger male patients in whom ulceration makes a greater impact on HRQoL.
authors.affiliation: Centre for Research and Implementation of Clinical Practice, Thames Valley University, London, UK.
authors.forename: P J
authors.initials: PJ
authors.lastname: Franks
authors.forename: C J
authors.initials: CJ
authors.lastname: Moffatt
mesh_terms: D000203:Activities of Daily Living; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D005260:Female; D006304:Health Status; D006801:Humans; D007871:Leg Ulcer / Q000503:physiopathology* / Q000523:psychology*; D008297:Male; D008571:Men / Q000523:psychology*; D010146:Pain / Q000209:etiology; D011788:Quality of Life; D012727:Sex Characteristics; D012737:Sex Factors; D014930:Women / Q000523:psychology*