Intracoronary radiation with a 32P source wire.
The Proliferation REduction with Vascular ENergy Trial (PREVENT) is a prospective randomized study of the safety and efficacy of intracoronary brachytherapy to reduce restenosis. A beta-emitter, 32P, is embedded on a wire tip and delivered to the target site through a centering catheter immediately following a coronary intervention. The radiation doses are 16, 20, and 24 Gy measured at 1 mm within the vessel wall. Follow-up includes an angiogram and IVUS at 6 months. Phase I of this trial has been completed with results expected in early 1999.
Lee
D P
DP
Division of Cardiovascular Medicine, Stanford University Medical Center, CA, USA.
Lo
S
S
Forster
K M
KM
Tate
D J
DJ
Raizner
A
A
Oesterle
S N
SN
D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation*; D001918:Brachytherapy / Q000295:instrumentation*; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D004867:Equipment Design; D005260:Female; D006801:Humans; D008297:Male; D010761:Phosphorus Radioisotopes / Q000627:therapeutic use*; D011446:Prospective Studies; D011879:Radiotherapy Dosage; D012008:Recurrence; D019233:Retreatment; D015607:Stents
D010761:Phosphorus Radioisotopes