Antioxidant activity of aminoethylcysteine ketimine decarboxylated dimer on copper-induced LDL oxidation.
Aminoethylcysteine ketimine decarboxylated dimer (AECK-DD), a member of a family of natural cyclic sulfur-containing aminoacids, recently detected in biological samples, protects low density lipoprotein (LDL) against copper-mediated oxidation, as assessed by monitoring the kinetics of conjugated diene formation, thiobarbituric acid-reactive substances production and LDL-tryptophan fluorescence quenching. Moreover, AECK-DD exerts a protective effect also against metal-independent, peroxyl radical-induced lipoprotein oxidation. It is of note that the concentrations exerting a protective effect against LDL oxidation are similar to those found in biological samples.
Matarese
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RM
Dipartimento di Scienze Biochimiche A. Rossi Fanelli, Università degli Studi La Sapienza, Roma, Italy. mmatarese@caspur.it
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Fontana
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Duprè
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Cavallini
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D000603:Amino Acids, Sulfur / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D053299:Apolipoprotein B-100; D001055:Apolipoproteins B / Q000737:chemistry; D003300:Copper / Q000494:pharmacology*; D019281:Dimerization; D006801:Humans; D066298:In Vitro Techniques; D015227:Lipid Peroxidation; D008077:Lipoproteins, LDL / Q000378:metabolism*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014364:Tryptophan / Q000737:chemistry
D000603:Amino Acids, Sulfur; D000975:Antioxidants; D053299:Apolipoprotein B-100; D001055:Apolipoproteins B; D008077:Lipoproteins, LDL; D017392:Thiobarbituric Acid Reactive Substances; C035497:thialysine ketimine; D003300:Copper; D014364:Tryptophan