A comparative study of reactogenicity and immunogenicity of an oral and an inactivated polio vaccine.
Reactogenicity and immunogenicity of the oral live attenuated (OPV) and inactivated polio vaccines (IPV) were studied in primary vaccination of toddlers. Three doses were administered simultaneously with DPT following the usual schedule valid in Croatia. The two groups of children had about 100 children each. Postvaccinal reactions were recorded for three days after each vaccination, and seroconversion was determined one month after the last injection. Although a conclusive analysis of postvaccinal reactions is not possible, since the staff of four different health centers apparently did not observe the same criteria, vaccination with IPV + DPT was not associated with remarkably more adverse events than OPV + DPT. Seroconversion rates attained with OPV ranged between 95.2% and 99.0%. With IPV, the rates were between 96.5% and 100%. Antibody levels for virus types 1, 2, and 3, as measured by GMT (reciprocal value), were 277, 1017, and 222 for OPV, and 465, 526, and 758 for IPV, respectively. IPV appears to be perfectly acceptable as a substitute for OPV for primary vaccination.
Borcić
B
B
Croatian Institute of Public Health, Zagreb, Croatia.
Dobrovsak-Sourek
V
V
Kaić
B
B
Ljubicić
M
M
D000914:Antibodies, Viral / Q000096:biosynthesis; D006801:Humans; D007223:Infant; D017955:Poliovirus / Q000276:immunology; D011054:Poliovirus Vaccine, Inactivated / Q000009:adverse effects / Q000276:immunology*; D011055:Poliovirus Vaccine, Oral / Q000009:adverse effects / Q000276:immunology; D014613:Vaccines, Attenuated / Q000009:adverse effects / Q000276:immunology; D015164:Vaccines, Inactivated / Q000009:adverse effects / Q000276:immunology
D000914:Antibodies, Viral; D011054:Poliovirus Vaccine, Inactivated; D011055:Poliovirus Vaccine, Oral; D014613:Vaccines, Attenuated; D015164:Vaccines, Inactivated