Effects of picotamide on release of endothelin-1, thromboxane and prostacycline after treadmill stress in patients with peripheral artery disease.
To assess the effects of picotamide, an antithromboxane receptor and antithromboxane synthase drug, on vascular function and endothelin-1 release, 20 patients with peripheral arterial disease, without hypertension or diabetes mellitus, receiving placebo and picotamide (900 mg/day) were studied. The modifications of vascular parameters were evaluated by arterial distensibility index and postischemic hyperemia test (postischemic perfusion index and recovery time). Endothelin-1, prostacycline, and thromboxane B2 were determined under resting conditions and after treadmill test. Picotamide treatment caused a decrease of resting thromboxane B2 and endothelin-1 concentrations, produced an improvement of the vascular function as seen by the increase of vascular parameters reported, and attenuated the ischemic treadmill-induced increase of thromboxane B2, but not of endothelin-1. These data confirm that the picotamide improved vascular flow by the reduction of thromboxane-mediated effects, reduced resting endothelin-1 levels, but did not attenuate endothelin-1 concentrations induced by the treadmill stress.
Saitta
A
A
Department of Internal Medicine and Medical Therapeutics, University of Messina, Italy.
Sardo
A
A
Bonaiuto
M
M
Giordano
G
G
Imbalzano
E
E
Castaldo
M
M
Cinquegrani
M
M
D'Arrigo
D
D
Campo
G M
GM
Squadrito
F
F
D000368:Aged; D019332:Endothelin-1 / Q000097:blood / Q000378:metabolism*; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000097:blood*; D010795:Phthalic Acids / Q000494:pharmacology*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011460:Prostaglandins F / Q000378:metabolism*; D013929:Thromboxane B2 / Q000097:blood / Q000378:metabolism*; D014666:Vasomotor System / Q000187:drug effects*
D019332:Endothelin-1; D010795:Phthalic Acids; D010975:Platelet Aggregation Inhibitors; D011460:Prostaglandins F; D013929:Thromboxane B2; C011581:picotamide; C100006:prostaglandin F1