title: Blastomycosis of the lumbar spine: case report and review of the literature, with emphasis on diagnostic laboratory tools and management.
abstract: We report on the conservative and surgical management of a patient with blastomycosis of the lumbar spine, causing severe and crippling deformity. The diagnosis was made through biopsy. Curative removal, reconstruction and realignment of the spine were achieved. Imaging modalities were highlighted, with a detailed discussion of the histology and conservative and surgical management. We emphasize the importance of early, aggressive treatment of blastomycosis to prevent deformity and disability, and to enable identification of the best management of a destructive lesion with deformity. This case demonstrates that empirical treatment should not be used in cases of unusual sinus and abscess locations. Specific diagnosis and early treatment are indicated to prevent dreadful complications and spinal deformity resulting from blastomycosis. Aggressive antifungal therapy can cure the disease but does not control complications related to deformity. The latter can only be addressed by surgical reconstruction. We review the literature of surgical treatment, focusing on abscess drainage, bone fusion and posterior instrumentation in the absence of addressing the deformity component.
authors.affiliation: University of Texas Medical Branch, Department of Orthopaedics and Rehabilitation, Galveston 77555-0792, USA.
authors.forename: A G
authors.initials: AG
authors.lastname: Hadjipavlou
authors.forename: J T
authors.initials: JT
authors.lastname: Mader
authors.forename: H J
authors.initials: HJ
authors.lastname: Nauta
authors.forename: J T
authors.initials: JT
authors.lastname: Necessary
authors.forename: G
authors.initials: G
authors.lastname: Chaljub
authors.forename: A
authors.initials: A
authors.lastname: Adesokan
mesh_terms: D000328:Adult; D001759:Blastomycosis / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000382:microbiology* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D013122:Spinal Diseases / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D014057:Tomography, X-Ray Computed