title: Localised non-Hodgkin's lymphoma: the Sheffield Lymphoma Group experience (1970-1995).
abstract: We report a retrospective study of all patients with localised non-Hodgkin's lymphoma referred to the Sheffield Lymphoma Group (1970-1995). A total of 1,979 patients with non-Hodgkin's lymphoma were seen: 553 (28%) presented with stage I or II disease, 411 (21%) extranodal, 142 (7%) nodal. The commonest extranodal sites were head and neck, gastrointestinal tract, skin and central nervous system, accounting for 87% of patients. Most patients received primary localised radiotherapy. Overall observed survival was 52.5% at 5 years in the extranodal group and 65% in the nodal group. For both groups the 10-year observed survival was 42.5%. An age of 45 years and over was a poor prognostic factor in both groups (p<0.001). Patients with skin and non-Waldeyer's head and neck lymphomas survived best (5-year observed survivals 67 and 70% respectively) and CNS worst (5-year survival 38%). There is no cause for complacency in the management of localised non-Hodgkin's lymphoma, particularly for the less common extranodal sites where multicentre clinical studies are still essential.
authors.affiliation: Yorkshire Cancer Research Section of Clinical Oncology, Weston Park Hospital, Sheffield, S10 2SJ, UK.
authors.forename: L S
authors.initials: LS
authors.lastname: Dobson
authors.forename: H
authors.initials: H
authors.lastname: Hancock
authors.forename: N
authors.initials: N
authors.lastname: Bright
authors.forename: M H
authors.initials: MH
authors.lastname: Robinson
authors.forename: B W
authors.initials: BW
authors.lastname: Hancock
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis* / Q000453:epidemiology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D006113:United Kingdom / Q000453:epidemiology