[Mechanisms of hemopoiesis cytostatic damage and regeneration].
Bone marrow hemopoiesis, a state of the committed precursor cell pool and the nature of their interaction with hemopoiesis-inducing microenvironment (HIM) elements, the level of humoral stimulants of secretion, was studied following a single injection of 5-fluorouracil (5-FU), cyclophosphamide (CF) or adriamycin (A) to mice in maximum tolerance doses. Cytostatic-related changes in hemopoietic recovery were shown to depend primarily on the proliferation-differentiation relationships in the hemopoietic cells, which is in its turn determined by the status of HIM cells after cytostatic exposure. The enhanced functional activity of HIM elements in response to hemopoietic tissue damage induced by A or CF promotes rapid hemopoietic recovery which becomes much more accelerated while using recombinant colony-stimulating factor (CSF) and, to a lesser degree, glycyrrham, a plant drug. At the same time 5-FU that caused prolonged bone marrow hypoplasia impaired the function of microenvironment cells. The use of this model demonstrated a lower efficiency of CSF than glycyrrham that normalized the structure of HIM.
Gol'dberg
E D
ED
Dygaĭ
A M
AM
Zdanov
V V
VV
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003115:Colony-Stimulating Factors / Q000494:pharmacology; D003520:Cyclophosphamide / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology; D005472:Fluorouracil / Q000494:pharmacology; D005500:Follow-Up Studies; D006410:Hematopoiesis / Q000187:drug effects / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000187:drug effects* / Q000502:physiology*; D051379:Mice; D011994:Recombinant Proteins; D012038:Regeneration / Q000187:drug effects / Q000502:physiology*
D000970:Antineoplastic Agents; D003115:Colony-Stimulating Factors; D011994:Recombinant Proteins; D004317:Doxorubicin; D003520:Cyclophosphamide; D005472:Fluorouracil
Mekhanizmy tsitostaticheskogo povrezdeniia i regeneratsii krovetvornoĭ sistemy.