dMi-2, a hunchback-interacting protein that functions in polycomb repression.
Early in Drosophila embryogenesis, gap gene products directly repress transcription of homeotic (HOX) genes and thereby delimit HOX expression domains. Subsequently, Polycomb-group proteins maintain this repression. Currently, there is no known molecular link between gap and Polycomb-group proteins. Here, dMi-2 is identified as a protein that binds to a domain in the gap protein Hunchback that is specifically required for the repression of HOX genes. Genetic analyses show that dMi-2 participates in both Hunchback and Polycomb repression in vivo. Hence, recruitment of dMi-2 may serve as a link between repression of HOX genes by Hunchback and Polycomb proteins.
Kehle
J
J
Max-Planck-Institut für Entwicklungsbiologie, Spemannstrasse 35/III, 72076 Tübingen, Germany.
Beuchle
D
D
Treuheit
S
S
Christen
B
B
Kennison
J A
JA
Bienz
M
M
Müller
J
J
D000251:Adenosine Triphosphatases; D000818:Animals; D001324:Autoantigens / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D004330:Drosophila / Q000196:embryology / Q000235:genetics; D029721:Drosophila Proteins; D004625:Embryo, Nonmammalian / Q000378:metabolism; D018628:Gene Dosage; D018507:Gene Expression Regulation, Developmental; D005801:Genes, Homeobox; D017344:Genes, Insect; D005816:Genetic Complementation Test; D005854:Germ Cells / Q000378:metabolism; D006579:Heterozygote; D018398:Homeodomain Proteins / Q000235:genetics; D017403:In Situ Hybridization; D019476:Insect Proteins / Q000235:genetics / Q000378:metabolism*; D009154:Mutation; D063150:Polycomb Repressive Complex 1; D011993:Recombinant Fusion Proteins; D014157:Transcription Factors / Q000378:metabolism*
C062393:Abd-B proteins, Drosophila; D001324:Autoantigens; D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D019476:Insect Proteins; C116095:Mi-2 protein, Drosophila; C066770:Pc protein, Drosophila; D011993:Recombinant Fusion Proteins; D014157:Transcription Factors; C066177:Ubx protein, Drosophila; C061245:hb protein, Drosophila; C071050:Psc protein, Drosophila; D063150:Polycomb Repressive Complex 1; D000251:Adenosine Triphosphatases