[Hypophyseal-adreno-gonadal system function in myasthenia patients with tumorous and nontumorous pathology of the thymus].
Overall twenty-five patients (all women) who ranged from 16 to 56 years old were examined. They were divided into two groups: group I was formed of subjects with hyperplasia of the thymus gland, group II--thymoma. Blood serum levels of prolactin, progesterone, estriol, estradiol, testosterone hydrocortisone. All patients showed a significant increase in average blood plasma levels of estrogens, testosterone and prolactin. Average levels of progesterone and hydrocortisone in patients with thymus hypertrophy were lower than in controls, while in thymoma patients these were much higher. The data submitted are indicative of substantial differences in the endocrine status of myasthenia patients depending on tumor or nontumor lesion of the thymus gland, which fact may suggest different pathogenetic mechanisms of development of the condition.
Lysenko
G I
GI
Shevniuk
M M
MM
Shatrova
K M
KM
Pshenichnaia
V A
VA
D000293:Adolescent; D000328:Adult; D005260:Female; D006728:Hormones / Q000097:blood; D006801:Humans; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000097:blood / Q000503:physiopathology* / Q000601:surgery; D010053:Ovary / Q000503:physiopathology*; D010913:Pituitary-Adrenal System / Q000503:physiopathology*; D013934:Thymectomy; D013945:Thymoma / Q000097:blood / Q000503:physiopathology* / Q000601:surgery; D013952:Thymus Hyperplasia / Q000097:blood / Q000503:physiopathology* / Q000601:surgery; D013953:Thymus Neoplasms / Q000097:blood / Q000503:physiopathology* / Q000601:surgery
D006728:Hormones
Sostoianie gipofizarno-adrenogonadnoĭ sistemy u bol'nykh miastenieĭ pri opukholevoĭ i neopukholevoĭ patologii vilochkovoĭ zhelezy.