title: Comparison of activated clotting times to heparin management test for adequacy of heparin anticoagulation in percutaneous transluminal coronary angioplasty.
abstract: The aim of this study was to compare the activated clotting time (ACT) obtained with the Hemochron device and the Heparin Management Test (HMT) on a new automated whole-blood coagulometer, the Thrombolytic Assessment System, in patients undergoing angioplasty. Fifty patients undergoing balloon angioplasty were prospectively enrolled. The mean ACT after a 10,000 unit bolus of heparin was 283 +/- 39 sec at the end of the procedure. The mean HMT after 10,000 units of heparin was 286 +/- 31 sec at the end of the procedure in the same patients. The correlation between the two methods was significant (r = 0.6; P < 0.01). The HMT appears to correlate well with standard values obtained with the Hemochron ACT monitor in patients undergoing percutaneous transluminal coronary angioplasty.
authors.affiliation: Clinique de Cardiologie, Hôpital Necker, Paris, France. jjb-lab@smtplink.mssm.edu
authors.forename: G
authors.initials: G
authors.lastname: Helft
authors.forename: S
authors.initials: S
authors.lastname: Choktron
authors.forename: F
authors.initials: F
authors.lastname: Beygui
authors.forename: C
authors.initials: C
authors.lastname: Le Feuvre
authors.forename: I
authors.initials: I
authors.lastname: Elalamy
authors.forename: J P
authors.initials: JP
authors.lastname: Metzger
authors.forename: A
authors.initials: A
authors.lastname: Vacheron
authors.forename: M M
authors.initials: MM
authors.lastname: Samama
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D000925:Anticoagulants / Q000008:administration & dosage / Q000627:therapeutic use*; D001777:Blood Coagulation / Q000187:drug effects*; D003328:Coronary Thrombosis / Q000517:prevention & control; D005500:Follow-Up Studies; D006493:Heparin / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007275:Injections, Intravenous; D017202:Myocardial Ischemia / Q000097:blood / Q000628:therapy*; D011446:Prospective Studies; D014914:Whole Blood Coagulation Time
chemical_list: D000925:Anticoagulants; D006493:Heparin