title: [Variants of the immune response in the dynamics of the localized form of stomatopharyngeal diphtheria in children].
abstract: 4 variants of immune response (IR) have been identified according to the dynamics of the development of nonspecific immunosuppression as determined in the reaction of lymphocyte blast transformation to phytohemagglutinin. These variants, characterized by a rise in the production of tumor necrosis factor alpha, interleukin 1 beta, immunoglobulins of 4 classes, are linked with the increased risk of the development of clinically pronounced forms (CPF) of diphtheria. The antigen-specific profile of each of these variants (types) of IR has been studied. Proofs of the fact that each type of IR has definite critical mechanisms of immune protection, contributing to the prevention of CPF of diphtheria, are presented. Treatment with antitoxic antidiphtheria serum produces different effect in 4 types of IR as it acts on different mechanisms of IR.
authors.affiliation: Research Institute of Child Infections, St. Petersburg, Russia.
authors.forename: G F
authors.initials: GF
authors.lastname: Zheleznikova
authors.forename: V V
authors.initials: VV
authors.lastname: Ivanova
authors.forename: A V
authors.initials: AV
authors.lastname: Mel'nikova
authors.forename: N E
authors.initials: NE
authors.lastname: Monakhova
authors.forename: Z U
authors.initials: ZU
authors.lastname: Gnilevskaia
authors.forename: A S
authors.initials: AS
authors.lastname: Kvetnaia
authors.forename: G P
authors.initials: GP
authors.lastname: Kurbatova
mesh_terms: D000293:Adolescent; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D000937:Antigen-Antibody Reactions; D002648:Child; D002675:Child, Preschool; D003176:Complement C3 / Q000096:biosynthesis; D004165:Diphtheria / Q000276:immunology*; D000939:Epitopes; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis; D007375:Interleukin-1 / Q000096:biosynthesis; D009055:Mouth / Q000382:microbiology*; D010614:Pharynx / Q000382:microbiology*
chemical_list: D000907:Antibodies, Bacterial; D003176:Complement C3; D000939:Epitopes; D007136:Immunoglobulins; D007375:Interleukin-1
vernacular_title: Varianty immunnogo otveta v dinamike lokalizovannoĭ formy difterii rotoglotki u deteĭ.