title: The mechanism of ceftazidime degradation in aqueous solutions.
abstract: Degradation of ceftazidime in aqueous solutions was studied at 298 K in acidic, basic and neutral conditions. The subsequent stage of hydrolysis involved the hydrolysis of the group at C-3, opening of the beta-lactam ring, and epimerization at C-6 or C-7. The decomposition of ceftazidime and the formation and identification of product C (pyridine) was followed by HPLC.
authors.affiliation: Department of Pharmaceutical Chemistry, K. Marcinkowski University of Medical Sciences, Poznań, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Zajac
authors.forename: J
authors.initials: J
authors.lastname: Siwek
authors.forename: I
authors.initials: I
authors.lastname: Muszalska
mesh_terms: D002442:Ceftazidime / Q000737:chemistry*; D002511:Cephalosporins / Q000737:chemistry*; D007202:Indicators and Reagents; D007700:Kinetics; D019999:Pharmaceutical Solutions / Q000032:analysis; D013056:Spectrophotometry, Ultraviolet
chemical_list: D002511:Cephalosporins; D007202:Indicators and Reagents; D019999:Pharmaceutical Solutions; D002442:Ceftazidime