title: Naproxen-associated sudden sensorineural hearing loss.
abstract: Naproxen is a commonly used nonsteroidal anti-inflammatory drug (NSAID) whose side effects include tinnitus and transient hearing loss. Sudden sensorineural hearing loss has rarely been reported as a result of NSAID use. This usually occurs in patients taking other ototoxic medications, with poor renal function, or with autoimmune disease. This article reports the case of an otherwise healthy patient who experienced permanent sensorineural hearing loss after a brief course of naproxen and reviews the literature on NSAID-related permanent sensorineural hearing loss.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Naval Medical Center, Portsmouth, VA 23708-2197, USA.
authors.forename: B J
authors.initials: BJ
authors.lastname: McKinnon
authors.forename: L F
authors.initials: LF
authors.lastname: Lassen
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D008889:Military Personnel; D009288:Naproxen / Q000009:adverse effects*; D011241:Prednisone / Q000627:therapeutic use; D014012:Tinnitus / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D009288:Naproxen; D011241:Prednisone