Organochlorine exposure and breast cancer risk in Colombian women.
An epidemiological study was performed in Santa Fé de Bogota, Colombia, with a total of 306 women enrolled, including 153 incident BC cases and 153 age-matched controls. The objective of this study was to evaluate the association between BC risk and serum dichlorodiphenyl-dichloroethene (DDE) levels. Sociodemographic and reproductive data, diet, and past exposure to pesticides were obtained through a structured questionnaire. Chemical analysis of samples was performed by high resolution gas chromatography-ECD. Likelihood of developing BC by exposure to these substances was evaluated through odds ratios (OR) adjusted for: first-child breast-feeding, family BC history, body mass index (BMI), parity, and menopausal status. Data analysis was performed by conditional logistic regression techniques. Adjusted OR for exposure to serum DDE and BC suggests an increase risk of BC in the higher category of DDE exposure (OR=1.95; CI 1.10-3.52). The test for trend was not statistically significant (p=0.09). We confirm that serum DDE levels bear a positive association to risk of BC and could support the association between risk of BC and burden of DDE exposure.
Olaya-Contreras
P
P
Instituto Nacional de Salud Pública de México. Avenida Universidad no 655, Santa María Ahuacatitlán, Cuernavaca, Morelos, México. olayac@insp3.insp.mx.
Rodríguez-Villamil
J
J
Posso-Valencia
H J
HJ
Cortez
J E
JE
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000097:blood / Q000139:chemically induced* / Q000453:epidemiology; D016022:Case-Control Studies; D003105:Colombia / Q000453:epidemiology; D004781:Environmental Exposure / Q000009:adverse effects* / Q000032:analysis / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D006843:Hydrocarbons, Chlorinated; D007306:Insecticides / Q000009:adverse effects* / Q000097:blood; D008875:Middle Aged; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014505:Urban Population / Q000706:statistics & numerical data
D006843:Hydrocarbons, Chlorinated; D007306:Insecticides