Hemopoietic mechanisms in allergic airway inflammation.
The bone marrow actively participates in the production of IgER-positive inflammatory cells (eosinophils, basophils and mast cells), which are typically recruited to tissues in atopic individuals. Understanding the signalling between the tissue and the bone marrow at the molecular level may well open up new avenues of therapy for allergic inflammation.
Denburg
J A
JA
Department of Medicine, McMaster University, Hamilton, Ont., Canada. denburg@fhs.csu.mcmaster.ca
Inman
M D
MD
Sehmi
R
R
Uno
M
M
O'Byrne
P M
PM
D001249:Asthma / Q000276:immunology*; D006410:Hematopoiesis / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology*