title: Diffusion-weighted magnetic resonance imaging in a case of cerebral venous thrombosis.
abstract: BACKGROUND
  Diffusion-weighted imaging (DWI) is the most sensitive MR sequence in acute arterial ischemic stroke but has not yet been evaluated in venous cerebral ischemia. We describe a patient with DWI performed at the acute phase of a venous ischemic stroke.
  
  
  METHODS
  A rapid cerebral MRI including DWI and fast fluid-attenuated inversion recovery (FLAIR) sequences was performed at the acute phase of a venous stroke confirmed by conventional angiography. DWI showed a slight decrease in apparent diffusion coefficient values 3 hours after onset (0.53+/-0.07x10(-3) mm2/s) and was normal 48 hours later (0.064+/-0.15x10(-3) mm2/s). Fast FLAIR sequences showed large left frontoparietal hyperintensities. The lack of a clear decrease in apparent diffusion coefficient values associated with marked FLAIR abnormalities may suggest prominent or early associated vasogenic edema. Physiopathological differences between arterial and venous ischemia may explain the different type of DWI FLAIR abnormalities during the acute phase as well as the better recovery of neurological deficit in venous stroke than in arterial ischemic stroke.
  
  
  CONCLUSIONS
  In the context of an acute stroke, the contrast between marked FLAIR and subtle DWI abnormalities on MRI may reflect the venous mechanism of cerebral ischemia.
authors.affiliation: Service d'Urgences Cérébro-Vasculaires, Groupe hospitalier Pitié-Salpétrière, Paris, France.
authors.forename: J C
authors.initials: JC
authors.lastname: Corvol
authors.forename: C
authors.initials: C
authors.lastname: Oppenheim
authors.forename: R
authors.initials: R
authors.lastname: Manaï
authors.forename: M
authors.initials: M
authors.lastname: Logak
authors.forename: D
authors.initials: D
authors.lastname: Dormont
authors.forename: Y
authors.initials: Y
authors.lastname: Samson
authors.forename: C
authors.initials: C
authors.lastname: Marsault
authors.forename: G
authors.initials: G
authors.lastname: Rancurel
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002533:Cerebral Angiography; D002561:Cerebrovascular Disorders / Q000175:diagnosis*; D003936:Diagnosis, Computer-Assisted; D004058:Diffusion; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D020246:Venous Thrombosis / Q000175:diagnosis*