title: Dual D2-receptor and beta2-adrenoceptor agonists for the treatment of airway diseases. 1. Discovery and biological evaluation of some 7-(2-aminoethyl)-4-hydroxybenzothiazol-2(3H)-one analogues.
authors.affiliation: Astra Charnwood, Bakewell Road, Loughborough, Leicestershire LE11 5RH, UK.
authors.forename: R V
authors.initials: RV
authors.lastname: Bonnert
authors.forename: R C
authors.initials: RC
authors.lastname: Brown
authors.forename: D
authors.initials: D
authors.lastname: Chapman
authors.forename: D R
authors.initials: DR
authors.lastname: Cheshire
authors.forename: J
authors.initials: J
authors.lastname: Dixon
authors.forename: F
authors.initials: F
authors.lastname: Ince
authors.forename: E C
authors.initials: EC
authors.lastname: Kinchin
authors.forename: A J
authors.initials: AJ
authors.lastname: Lyons
authors.forename: A M
authors.initials: AM
authors.lastname: Davis
authors.forename: C
authors.initials: C
authors.lastname: Hallam
authors.forename: S T
authors.initials: ST
authors.lastname: Harper
authors.forename: J F
authors.initials: JF
authors.lastname: Unitt
authors.forename: I G
authors.initials: IG
authors.lastname: Dougall
authors.forename: D M
authors.initials: DM
authors.lastname: Jackson
authors.forename: K
authors.initials: K
authors.lastname: McKechnie
authors.forename: A
authors.initials: A
authors.lastname: Young
authors.forename: W T
authors.initials: WT
authors.lastname: Simpson
mesh_terms: D058666:Adrenergic beta-2 Receptor Agonists; D000318:Adrenergic beta-Agonists / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D016084:Bronchoconstriction / Q000187:drug effects; D004285:Dogs; D018491:Dopamine Agonists / Q000138:chemical synthesis* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004423:Ear / Q000098:blood supply; D066298:In Vitro Techniques; D008173:Lung Diseases, Obstructive / Q000188:drug therapy*; D009093:Mucus / Q000187:drug effects; D011817:Rabbits; D017448:Receptors, Dopamine D2 / Q000819:agonists*; D012119:Respiration / Q000187:drug effects; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D058666:Adrenergic beta-2 Receptor Agonists; D000318:Adrenergic beta-Agonists; D018927:Anti-Asthmatic Agents; D018491:Dopamine Agonists; D017448:Receptors, Dopamine D2; D013844:Thiazoles; C116267:sibenadet