title: Synthesis and antimicrobial activity of N-Mannich bases of 3-[N'-sulphadoximino] isatin and its methyl derivative.
abstract: Schiff's bases of isatin and 5-methyl isatin with sulphadoxine and then its N-Mannich bases were synthesised and evaluated for their anti-microbial activity. The piperidonemethyl group improved the activity and most of the compounds were more potent than the pure drugs.
authors.affiliation: Department of Pharmaceutics, Banaras Hindu University, Varanasi, India.
authors.lastname: Surendra
authors.forename: N
authors.initials: N
authors.lastname: Pandeya
authors.forename: P
authors.initials: P
authors.lastname: Yogeeswari
authors.forename: D S
authors.initials: DS
authors.lastname: Ram
authors.forename: G
authors.initials: G
authors.lastname: Nath
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D007510:Isatin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008352:Mannich Bases / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D008352:Mannich Bases; D007510:Isatin