Pathophysiology of meningococcal sepsis in children.
Septic shock with purpura is a syndrome frequently diagnosed in children and predominantly caused by Neisseria meningitidis. Despite improvements in management and therapy the mortality and morbidity in these patients are still high. During the last few years much effort has been put into understanding of the systemic host response during this acute infectious disease. This host response can be divided into the process of recognition of endotoxin, the cascade of pro- and counter inflammatory mediators, the endothelial damage resulting in capillary leakage and inappropriate vascular tone, and the procoagulant state.


CONCLUSIONS
This paper reviews the recent insights in the pathophysiology of the host response and their possible consequences for novel therapies in meningococcal sepsis.
de Kleijn
E D
ED
Sophia Children's Hospital, Rotterdam, The Netherlands.
Hazelzet
J A
JA
Kornelisse
R F
RF
de Groot
R
R
D001778:Blood Coagulation Disorders / Q000503:physiopathology; D003165:Complement System Proteins / Q000502:physiology; D016207:Cytokines / Q000097:blood; D004731:Endotoxins; D005342:Fibrinolysis; D006801:Humans; D008070:Lipopolysaccharides; D008589:Meningococcal Infections / Q000097:blood / Q000503:physiopathology* / Q000628:therapy; D018805:Sepsis / Q000097:blood / Q000382:microbiology / Q000503:physiopathology* / Q000628:therapy; D012772:Shock, Septic / Q000097:blood / Q000503:physiopathology / Q000628:therapy
D016207:Cytokines; D004731:Endotoxins; D008070:Lipopolysaccharides; D003165:Complement System Proteins