title: Neuroanatomical aspects of cognitive-behavioural therapy response in obsessive-compulsive disorder. An evolving perspective on brain and behaviour.
abstract: BACKGROUND
  Recent research has demonstrated that cognitive-behavioural therapy (CBT) for obsessive-compulsive disorder (OCD) can systematically modify cerebral metabolic activity in a manner which is significantly related to clinical outcome.
  
  
  METHODS
  A substantial body of research is reviewed which supports an involvement of neural circuitry connecting the orbitofrontal cortex, cingulate gyrus and basal ganglia in the expression of the symptoms of OCD.
  
  
  RESULTS
  Data are presented which expand upon previous work demonstrating effects of CBT on functional interactions between limbic cortex and the basal ganglia.
  
  
  CONCLUSIONS
  The relevance of these effects of CBT on brain function is discussed in the context of recent advances in our knowledge of cortical-basal ganglia physiology. The clinical importance of these data is best appreciated when they are seen to reflect the interactive nature of the relationships between cognitive choice, behavioural output and brain activity.
authors.affiliation: UCLA Department of Psychiatry 90024-1759, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Schwartz
mesh_terms: D001521:Behavior Therapy / Q000379:methods; D001526:Behavioral Symptoms / Q000473:pathology / Q000523:psychology / Q000628:therapy; D001927:Brain Diseases / Q000378:metabolism*; D003072:Cognition Disorders / Q000473:pathology / Q000523:psychology / Q000628:therapy; D015928:Cognitive Behavioral Therapy / Q000379:methods; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000378:metabolism / Q000473:pathology* / Q000523:psychology / Q000628:therapy