In vitro susceptibility of recent gram-positive isolates to ciprofloxacin, levofloxacin, and trovafloxacin.
Gram-positive isolates (n = 290) were tested for their susceptibility to three fluoroquinolone antibiotics by standard disk-diffusion technology. Overall, 59%, 72%, and 85% were susceptible and 29%, 25%, and 11% were resistant to ciprofloxacin, levofloxacin, and trovafloxacin, respectively. Of Staphylococcus aureus isolates (n = 84), 55%, 57%, and 88% were susceptible to the three antibiotics, respectively. Staphylococcus epidermidis (n = 45), too, was more susceptible to trovafloxacin, although the differences were smaller (60%, 62%, and 78%). Of 35 Enterococcus faecalis isolates, 66% and 74% were susceptible to levofloxacin and trovafloxacin, respectively, but only 9% were susceptible to ciprofloxacin.
Isenberg
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HD
Division of Microbiology, Long Island Jewish Medical Center, Albert Einstein College of Medicine, New Hyde Park, New York 11042, USA.
Alperstein
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P
France
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K
D000890:Anti-Infective Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology*; D003352:Corynebacterium / Q000187:drug effects / Q000302:isolation & purification; D004352:Drug Resistance, Microbial; D024841:Fluoroquinolones; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology*; D006095:Gram-Positive Cocci / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D064704:Levofloxacin; D008826:Microbial Sensitivity Tests; D009287:Naphthyridines / Q000494:pharmacology*; D015242:Ofloxacin / Q000494:pharmacology*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; D002939:Ciprofloxacin; D064704:Levofloxacin; C080163:trovafloxacin; D015242:Ofloxacin