Dose-dependent inhibition of postprandial gallbladder motility and plasma hormone secretion during acute hyperglycemia.
BACKGROUND
Actual blood glucose concentrations influence gastrointestinal function. We investigated whether in healthy subjects the inhibitory effect of acute hyperglycemia on gallbladder motility is dose-dependent.


METHODS
Seven healthy volunteers were studied on four separate occasions in random order during euglycemia and during hyperglycemic clamping, at 4 mmol/l, 8 mmol/l, 12 mmol/l, and 16 mmol/l, respectively. Gallbladder volumes (ultrasonography) and plasma hormone release were studied before and after ingestion of a meal.


RESULTS
Postprandial gallbladder contraction was significantly (P < 0.05) and dose-dependently inhibited during the hyperglycemic experiments at 8, 12, and 16 mmol/l (56%+/-8%, 49%+/-8%, and 30%+/-5%, respectively) compared with euglycemia (68%+/-6%). Postprandial cholecystokinin release was significantly (P < 0.05) reduced compared with euglycemia only at a plasma glucose level of 16 mmol/l (116+/-28 versus 159+/-13 pmol x l(-1) x 120 min). Plasma pancreatic polypeptide secretion, as an indirect measure of vagal-cholinergic tone, was significantly (P < 0.05) and dose-dependently reduced during hyperglycemia at 8, 12, and 16 mmol/l.


CONCLUSIONS
In healthy subjects acute hyperglycemia significantly and dose-dependently inhibits postprandial gallbladder motility. Future studies on gallbladder motility should take into account the influence of plasma glucose, because already at postprandial glucose levels gallbladder motility is reduced.
Gielkens
H A
HA
Dept. of Gastroenterology-Hepatology, Leiden University Medical Center, The Netherlands.
van Oostayen
J A
JA
Frölich
M
M
Biemond
I
I
Lamers
C B
CB
Masclee
A A
AA
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D002766:Cholecystokinin / Q000097:blood* / Q000378:metabolism; D005260:Female; D016473:Gallbladder Emptying / Q000502:physiology*; D015309:Glucose Clamp Technique; D006801:Humans; D007328:Insulin / Q000097:blood* / Q000378:metabolism; D000078790:Insulin Secretion; D008297:Male; D010191:Pancreatic Polypeptide / Q000097:blood* / Q000378:metabolism; D019518:Postprandial Period; D011897:Random Allocation
D001786:Blood Glucose; D007328:Insulin; D010191:Pancreatic Polypeptide; D002766:Cholecystokinin