title: Enterovirus associated neurological disease in an HIV-1 infected man.
abstract: We report a case of relapsing multifocal neurological disease associated with CNS echovirus 6 infection in an HIV-1-infected individual with no evidence of immunoglobulin deficiency. The illness was initially characterized by optic and cranial neuropathies and myelopathy; concurrent granulomatous hepatitis suggested disseminated viral infection. Treatment with combination nucleoside analogues led to partial remission, but a demyelinating polyneuropathy subsequently developed. There was improvement and sustained remission in the polyneuropathy following treatment with intravenous immunoglobulin. Neurotropic enterovirus infection may be involved in the pathogenesis of certain HIV-associated neurological syndromes.
authors.affiliation: Department of Clinical Immunology, Royal Perth Hospital, Western Australia, Australia.
authors.forename: J R
authors.initials: JR
authors.lastname: Dyer
authors.forename: R H
authors.initials: RH
authors.lastname: Edis
authors.forename: M A
authors.initials: MA
authors.lastname: French
mesh_terms: D000328:Adult; D003389:Cranial Nerve Diseases / Q000150:complications / Q000821:virology; D003711:Demyelinating Diseases / Q000150:complications / Q000821:virology; D004458:Echovirus 6, Human / Q000302:isolation & purification*; D004769:Enterovirus Infections / Q000150:complications / Q000503:physiopathology / Q000628:therapy / Q000821:virology*; D015658:HIV Infections / Q000150:complications* / Q000821:virology; D015497:HIV-1; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008297:Male; D009422:Nervous System Diseases / Q000150:complications / Q000821:virology*
chemical_list: D016756:Immunoglobulins, Intravenous