[Uveitis in Whipple disease: Identification of Trophyrema whippelii by PCR].
Whipple's disease is a multisystem bacterial disease usually characterized by malabsorption, diarrhea and polyarthritis. Ocular manifestations include uveitis, vitreitis, retinis, myositis, papilledema and optic atrophy. We report a case of a chronic bilateral vitreitis in a 63 year-old man who had been treated for a Whipple's disease with gastrointestinal involvement 30 years before. The jejunal biopsy was negative but the polymerase-chain-reaction (PCR) revealed the presence of Trophyrema Whippelii in the vitreous prelevement of both eye. This new, original strategy of PCR is specific and more sensitive than histological diagnosis.
Sommer
S
S
Service d'Ophtalmologie, CHR Metz Thionville, Hôpital N.D. de Bonsecours, Metz.
Rozot
P
P
Wagner
M
M
Xenard
L
L
Poveda
J D
JD
D000190:Actinomyces / Q000235:genetics / Q000302:isolation & purification*; D001706:Biopsy; D003937:Diagnosis, Differential; D006801:Humans; D007583:Jejunum / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D014605:Uveitis / Q000175:diagnosis* / Q000382:microbiology; D014822:Vitreous Body / Q000382:microbiology*; D008061:Whipple Disease / Q000175:diagnosis* / Q000382:microbiology
D012336:RNA, Ribosomal, 16S
Uvéite et maladie de Whipple: identification du Trophyrema whippelii par PCR.