title: Antioxidant activity of aminoethylcysteine ketimine decarboxylated dimer on copper-induced LDL oxidation.
abstract: Aminoethylcysteine ketimine decarboxylated dimer (AECK-DD), a member of a family of natural cyclic sulfur-containing aminoacids, recently detected in biological samples, protects low density lipoprotein (LDL) against copper-mediated oxidation, as assessed by monitoring the kinetics of conjugated diene formation, thiobarbituric acid-reactive substances production and LDL-tryptophan fluorescence quenching. Moreover, AECK-DD exerts a protective effect also against metal-independent, peroxyl radical-induced lipoprotein oxidation. It is of note that the concentrations exerting a protective effect against LDL oxidation are similar to those found in biological samples.
authors.affiliation: Dipartimento di Scienze Biochimiche A. Rossi Fanelli, Università degli Studi La Sapienza, Roma, Italy. mmatarese@caspur.it
authors.forename: R M
authors.initials: RM
authors.lastname: Matarese
authors.forename: A
authors.initials: A
authors.lastname: Macone
authors.forename: M
authors.initials: M
authors.lastname: Fontana
authors.forename: S
authors.initials: S
authors.lastname: Duprè
authors.forename: D
authors.initials: D
authors.lastname: Cavallini
mesh_terms: D000603:Amino Acids, Sulfur / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D053299:Apolipoprotein B-100; D001055:Apolipoproteins B / Q000737:chemistry; D003300:Copper / Q000494:pharmacology*; D019281:Dimerization; D006801:Humans; D066298:In Vitro Techniques; D015227:Lipid Peroxidation; D008077:Lipoproteins, LDL / Q000378:metabolism*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014364:Tryptophan / Q000737:chemistry
chemical_list: D000603:Amino Acids, Sulfur; D000975:Antioxidants; D053299:Apolipoprotein B-100; D001055:Apolipoproteins B; D008077:Lipoproteins, LDL; D017392:Thiobarbituric Acid Reactive Substances; C035497:thialysine ketimine; D003300:Copper; D014364:Tryptophan