title: Blood group antigens in differentiated thyroid neoplasms.
abstract: Alteration of cell-surface blood group antigens during malignant transformation is a well-known phenomenon that has not yet been sufficiently investigated in thyroid gland neoplasms. We evaluated 50 normal thyroid glands and 141 differentiated thyroid neoplasms (29 follicular adenomas, 30 follicular carcinomas, 56 papillary carcinomas, and 26 medullary carcinomas) both by the immunoperoxidase technique, using monoclonal antibodies against blood group antigens (A, B, H, Le(a), Le(b), Le(x), and Le(y)) and precursor substances (T, Tn, and sTn), and by affinity to the lectin from Arachis hypogea, to determine the usefulness of these antigens as tumor markers and prognostic factors. Neoplastic tissues showed immunostaining with concordant and nonconcordant expression of ABH antigens. There were statistically significant differences between normal and neoplastic tissues but not among the different neoplasms. Statistically significant differences in Lewis antigen expression were noted between normal and neoplastic tissues and between benign and malignant tumors. Tn and sTn antigen expression showed statistically significant differences between normal and neoplastic tissues. In conclusion, blood group antigens are tumor markers that are expressed more frequently in malignant than in benign neoplasms. The presence of metastases was correlated with enhanced peanut lectin receptors and a loss of A or B antigens.
authors.affiliation: Department of Pathology, Hospital Universitario Virgen Macarena, University of Seville, Spain.
authors.forename: R
authors.initials: R
authors.lastname: González-Cámpora
authors.forename: J A
authors.initials: JA
authors.lastname: García-Sanatana
authors.forename: M M
authors.initials: MM
authors.lastname: Jordà i Heras
authors.forename: C O
authors.initials: CO
authors.lastname: Salaverri
authors.forename: F J
authors.initials: FJ
authors.lastname: Vázquez-Ramírez
authors.forename: O E
authors.initials: OE
authors.lastname: Argueta-Manzano
authors.forename: H
authors.initials: H
authors.lastname: Galera-Davidson
mesh_terms: D000017:ABO Blood-Group System / Q000032:analysis*; D018263:Adenocarcinoma, Follicular / Q000737:chemistry* / Q000473:pathology; D000236:Adenoma / Q000737:chemistry* / Q000473:pathology; D000911:Antibodies, Monoclonal; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis; D014408:Biomarkers, Tumor; D018276:Carcinoma, Medullary / Q000737:chemistry* / Q000473:pathology; D002291:Carcinoma, Papillary / Q000737:chemistry* / Q000473:pathology; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D011379:Prognosis; D013961:Thyroid Gland / Q000737:chemistry; D013964:Thyroid Neoplasms / Q000737:chemistry* / Q000473:pathology
chemical_list: D000017:ABO Blood-Group System; D000911:Antibodies, Monoclonal; D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor