A novel indication of the activities of small molecule inhibitors of protein-protein interactions: application of the yeast two-hybrid system.
Igarashi
K
K
Life Science Research Center, Advanced Technology Research Laboratories, Nippon Steel Corporation, Kawasaki, Japan.
Shigeta
K
K
Kohno
S
S
Isohara
T
T
Yamano
T
T
Uno
I
I
D002455:Cell Division / Q000187:drug effects; D003513:Cycloheximide / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006639:Histidine / Q000378:metabolism / Q000494:pharmacology; D006822:Hybrid Cells; D020104:Immunophilins / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D009963:Orotic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D011500:Protein Synthesis Inhibitors; D018125:Receptors, Transforming Growth Factor beta / Q000187:drug effects / Q000378:metabolism; D016559:Tacrolimus / Q000031:analogs & derivatives / Q000494:pharmacology; D022021:Tacrolimus Binding Proteins; D015003:Yeasts / Q000187:drug effects* / Q000235:genetics* / Q000254:growth & development
D004791:Enzyme Inhibitors; D011500:Protein Synthesis Inhibitors; D018125:Receptors, Transforming Growth Factor beta; D006639:Histidine; D009963:Orotic Acid; C001242:5-fluoroorotic acid; D003513:Cycloheximide; C058028:immunomycin; D022021:Tacrolimus Binding Proteins; D020104:Immunophilins; D016559:Tacrolimus