Tumor versus vascular photodamage in a rat tumor model.
The [4-(5-nitro-2-furyl)-2-thiazoyl] formamide (FANFT)-induced urothelial tumor in the rat is found to express the mdr gene. The resulting multidrug resistance (MDR) phenotype results in the expression of an outward transport system that prevents cellular accumulation of certain weakly cationic agents. Among the latter is a photosensitizer with known efficacy for the FANFT tumor, the copper benzochlorin iminium salt. FANFT cells are protected from direct cell kill mediated by this drug, suggesting that the substantial delay in tumor regrowth from this tumor/sensitizer combination can be attributed to vascular effects.
Kessel
D
D
Wayne State University, School of Medicine, Detroit, MI 48021, USA. dhkessel@med.wayne.edu
Hampton
J
J
Fingar
V
V
Morgan
A
A
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000096:biosynthesis; D000818:Animals; D001692:Biological Transport; D002470:Cell Survival; D003905:Deuteroporphyrins / Q000493:pharmacokinetics*; D018432:Drug Resistance, Multiple / Q000235:genetics*; D005200:FANFT; D007097:Imines / Q000493:pharmacokinetics*; D010777:Photochemistry; D017319:Photosensitizing Agents / Q000493:pharmacokinetics*; D051381:Rats; D014407:Tumor Cells, Cultured; D014571:Urologic Neoplasms / Q000139:chemically induced / Q000235:genetics / Q000473:pathology*
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D003905:Deuteroporphyrins; D007097:Imines; D017319:Photosensitizing Agents; C081504:copper benzochlorin; D005200:FANFT