Vulvar squamous carcinoma: prognostic role of DNA content.
DNA nuclear content was evaluated on 46 paraffin-embedded blocks of vulvar cancer by means of flow cytometry. Fifteen of 44 evaluable samples (34%) were found to have an aneuploid DNA pattern. Aneuplody showed a statistically significant relationship with tumor grading (P = 0.0004) and defined a subset of patients who have pathological characteristics of high risk, such as advanced stage of disease, deepest stromal invasion, or positive inguinal nodes. However, when a multivariate regression model was used, ploidy status did not have any prognostic role, while FIGO staging system was confirmed to be the strongest independent prognostic factor (P = 0.009). The integration of a panel of cell kinetic parameters with traditional features is worth investigating on a larger population.
Mariani
L
L
Department of Gynecologic Oncology, Regina Elena Cancer Institute of Rome, Rome, 00162, Italy.
Conti
L
L
Atlante
G
G
Sciarretta
F
F
Pozzi
M
M
Vercillo
M
M
Francavilla
V
V
De Franceschi
L
L
Rossi
S
S
Sindico
R
R
Atlante
M
M
Gandolfo
G M
GM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000473:pathology; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D011003:Ploidies; D011379:Prognosis; D012189:Retrospective Studies; D014846:Vulvar Neoplasms / Q000401:mortality* / Q000473:pathology
D004273:DNA, Neoplasm