L-asparaginase (Leunase) induced pancreatitis in childhood acute lymphoblastic leukemia.
A major complication of L-asparaginase therapy in acute lymphoblastic leukemia (ALL) is pancreatitis. Among the 915 cases of ALL seen over last 10 years, 19 (2%) developed pancreatitis. Median age was 5.5 years with a median duration of symptoms of 4 weeks. All cases had raised serum amylase and lipase. Pancreatitis was not related to the dose/duration of L-asparaginase therapy. Ultrasonography can be used as a corroborative investigation for diagnosis along with serum chemistries. Close clinical monitoring of children for early diagnosis of this complication is recommended.
Sahu
S
S
Department of Medical Oncology, Tata Memorial Hospital, Parel, Mumbai, India.
Saika
S
S
Pai
S K
SK
Advani
S H
SH
D000293:Adolescent; D000681:Amylases / Q000097:blood; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001215:Asparaginase / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D006801:Humans; D008049:Lipase / Q000097:blood; D010195:Pancreatitis / Q000097:blood / Q000139:chemically induced* / Q000503:physiopathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*
D000970:Antineoplastic Agents; D008049:Lipase; D000681:Amylases; D001215:Asparaginase