title: Gastric myoelectrical activity in healthy children and children with functional dyspepsia.
abstract: The aim of this study was to investigate abnormalities in pediatric patients with functional dyspepsia. Fifteen symptomatic pediatric patients diagnosed with functional dyspepsia and 17 aged-matched healthy controls were studied. Gastric myoelectrical activity was recorded using surface electrogastrography for 1 hr in the fasting state and 1 hr after a test meal. It was found that, in comparison with the controls, the children with functional dyspepsia had a lower percentage of 2- to 4-cpm slow waves in both fasting state (66.0+/-4.7% vs 79.7+/-3.1%, P < 0.07) and fed state (72.4+/-5.4% vs 85.0+/-2.9%, P < 0.04), and a significantly higher instability of the dominant frequency in both fasting state (0.50+/-0.05 vs 0.31+/-0.04, P < 0.01) and fed state (0.39+/-0.05 vs 0.25+/-0.03, P < 0.05). It was also found the postprandial increase in EGG dominant power in the patients was inversely correlated with the total symptom score (r = 0.63, P = 0.03). It was concluded that abnormal gastric myoelectrical activity may play a role in the pathogenesis of pediatric functional dyspepsia.
authors.affiliation: Thomas N. Lynn Institute for Healthcare Research, INTEGRIS Baptist Medical Center, Oklahoma City, Oklahoma 73112, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Chen
authors.forename: X
authors.initials: X
authors.lastname: Lin
authors.forename: M
authors.initials: M
authors.lastname: Zhang
authors.forename: R B
authors.initials: RB
authors.lastname: Torres-Pinedo
authors.forename: W C
authors.initials: WC
authors.lastname: Orr
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004415:Dyspepsia / Q000503:physiopathology*; D004566:Electrodes; D004568:Electrodiagnosis / Q000295:instrumentation / Q000379:methods / Q000706:statistics & numerical data; D005215:Fasting / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D016065:Myoelectric Complex, Migrating / Q000502:physiology*; D019518:Postprandial Period; D012016:Reference Values; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation; D018709:Statistics, Nonparametric; D013270:Stomach / Q000503:physiopathology