title: An unusual panniculitis appearing in the winter with good response to tetracycline.
abstract: Cold panniculitis is a form of physical panniculitis due to exposure of skin to severe cold. It usually appears on the cheeks of infants and children. It has also been reported on the thighs and buttocks of young females. Its clinical manifestations include red, cold, indurated plaques or nodules which appear one to three days after exposure to low temperatures and resolve spontaneously within several weeks without scarring. The histopathological picture shows a perivascular infiltrate of lymphoid and histiocytic cells at the dermal-subcutaneous junction in the early phase of the reaction (1). After 48 to 72 hours, a well developed panniculitis appears. We report an unusual case of an adult female patient with recurrent panniculitis on her legs appearing in the winter but without any preceding repeated or prolonged exposure to cold. She responded dramatically to oral tetracycline. This drug was successful as a prophylactic agent as well.
authors.affiliation: Department of Pathology, University of Athens, Greece.
authors.forename: K
authors.initials: K
authors.lastname: Aroni
authors.forename: M
authors.initials: M
authors.lastname: Aivaliotis
authors.forename: E
authors.initials: E
authors.lastname: Tsele
authors.forename: D
authors.initials: D
authors.lastname: Charalambopoulos
authors.forename: P
authors.initials: P
authors.lastname: Davaris
mesh_terms: D000284:Administration, Oral; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003080:Cold Temperature / Q000009:adverse effects; D020405:Dermis / Q000473:pathology; D004781:Environmental Exposure; D005260:Female; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D007868:Leg Dermatoses / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D008875:Middle Aged; D015434:Panniculitis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D012008:Recurrence; D012621:Seasons; D013752:Tetracycline / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D013752:Tetracycline