Syntheses of S,N-substituted 2-mercaptobenzenesulfonamide derivatives with potential pharmacological activity.
A series of [5-chloro-4-methyl-2-sulfamoylphenyl(thio or sulfonyl)]alkanoic acids [I-VI], their methyl esters [VII-XII] and hydrazides [XIII-XXI] were prepared. The treatment of the selected esters [VII-VIII, XI-XII] with appropriate biguanide hydrochlorides gave 4-chloro-5-methyl-2-[2-amino-6-R3-triazin-4-ylalkyl(thio or sulfonyl)]benzenesulfonamides [XXII-XXVII]. The anticancer activity was observed in vitro for compound [XXII].
Pomarnacka
E
E
Department of Chemical Drug Technology, Medical University of Gdańsk, Poland.
Kornicka
A
A
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013055:Spectrophotometry, Infrared; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D013449:Sulfonamides