title: [Epidemiologic and genetic studies of canine hip dysplasia in a population of Labrador retrievers: a study over 25 years].
abstract: The occurrence of canine hip dysplasia (CHD) was analyzed in a colony of 738 Labrador Retrievers between 1972 and 1996. Of these dogs, 86.3% were radiographically examined for hip dysplasia. The overall prevalence of CHD was 31.3% during the study period of 25 years. Between 1972 and 1980, the prevalence of CHD was 57.9%. It decreased to 14.9% between 1991 and 1996. Univariate and multivariate logistic regression models were developed to identify the influence of potential risk factors for CHD such as age at examination, gender, color, year and season of birth, litter size, order of birth, birth weight, body weight and daily weight gain. Birth year and age at examination proved to be significant risk factors. No significant association was found between CHD and elbow dysplasia. Of the dogs diagnosed with CHD, 18% showed dysplastic changes only, without radiographic signs of secondary osteoarthritis (OA). The Norberg angle (NA) proved to be a significant risk factor for coxofemoral osteoarthritis with a moderate negative correlation between OA and NA. Finally, genetic effects were calculated in a mixed model. Heritability (h2) of CHD was estimated at 0.53 (SE = 0.17) for paternal half siblings. The proportion of the common environment of a litter to the total variance was estimated at C2 = 0.03.
authors.affiliation: Abteilung für Kleintierradiologie, Universität Bern.
authors.forename: S
authors.initials: S
authors.lastname: Ohlerth
authors.forename: A
authors.initials: A
authors.lastname: Busato
authors.forename: C
authors.initials: C
authors.lastname: Gaillard
authors.forename: M
authors.initials: M
authors.lastname: Flückiger
authors.forename: J
authors.initials: J
authors.lastname: Lang
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001724:Birth Weight; D001835:Body Weight; D004285:Dogs; D005260:Female; D005858:Germany / Q000453:epidemiology; D006619:Hip Dysplasia, Canine / Q000453:epidemiology* / Q000503:physiopathology; D008098:Litter Size; D008297:Male; D015995:Prevalence; D013045:Species Specificity; D013997:Time Factors
vernacular_title: Epidemiologische und genetische Untersuchungen zur Hüftgelenksdysplasie an einer Population von Labrador Retrievern: Eine Studie über 25 Jahre.