Anti-inflammatory drugs interacting with Zn(II), Cd(II) and Pt(II) metal ions.
Complexes of Zn(II), Cd(II) and Pt(II) metal ions with the anti-inflammatory drugs, 1-methyl-5-(p-toluoyl)-1H-pyrrole-2-acetic acid (Tolmetin), alpha-methyl-4-(2-methylpropyl)benzeneacetic acid (Ibuprofen), 6-methoxy-alpha-methylnaphthalene-2-acetic acid (Naproxen) and 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid (indomethacin) have been synthesized and characterized. In the structurally characterized Cd(naproxen)2 complex the anti-inflammatory drugs acts as bidentate chelate ligand coordinatively bound to metal ions through the deprotonated carboxylate group. Crystal data for 1: [C32H26O8Cd], orthorhombic, space group P22(1)2(1), a = 5.693(2) (A), b = 8.760(3) (A), c = 30.74(1) (A), V = 1533(1) A3, Z = 2. Antibacterial and growth inhibitory activity is higher than that of the parent ligands or the platinum(II) diamine compounds.
Dendrinou-Samara
C
C
Department of Chemistry, Aristotle University of Thessaloniki, Greece.
Tsotsou
G
G
Ekateriniadou
L V
LV
Kortsaris
A H
AH
Raptopoulou
C P
CP
Terzis
A
A
Kyriakidis
D A
DA
Kessissoglou
D P
DP
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002104:Cadmium / Q000494:pharmacology*; D002413:Cations, Divalent; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002614:Chelating Agents; D006224:Cricetinae; D018360:Crystallography, X-Ray; D004347:Drug Interactions; D006801:Humans; D007052:Ibuprofen / Q000737:chemistry / Q000494:pharmacology; D066298:In Vitro Techniques; D007213:Indomethacin / Q000737:chemistry / Q000494:pharmacology; D008024:Ligands; D008958:Models, Molecular; D010984:Platinum / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014046:Tolmetin / Q000737:chemistry / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D015032:Zinc / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002413:Cations, Divalent; D002614:Chelating Agents; D008024:Ligands; D002104:Cadmium; D010984:Platinum; D014046:Tolmetin; D015032:Zinc; D007052:Ibuprofen; D007213:Indomethacin