title: Chiari Type I malformation and syringomyelia in unrelated patients with blepharophimosis. Report of two cases.
abstract: Syringomyelia is a rare, mainly sporadic disease of the spinal cord, which is associated with 80% of cases in which a Chiari Type I malformation is also present. A mendelian transmission of syringomyelia (autosomal dominant or recessive) has been proposed in approximately 2% of reported cases. The association of syringomyelia with hereditary diseases (Noonan's syndrome, phacomatoses) has been mentioned frequently in the literature. The authors report the presence of a Chiari Type I malformation accompanied by syringomyelia in two unrelated patients affected by a familial Type II blepharophimosis-ptosis-epicanthus inversus syndrome (BPES). The first patient was a 35-year-old woman who presented with a right C-8 root paresia. The second case involved a 20-year-old man who complained of cervical radicular pain. Both belong to families in which BPES was segregated in an autosomal dominant modality, but other family members had no known neurological symptoms. To the authors' knowledge, such a combination has never been described. Perhaps the possible involvement of a genetic component in some cases of Chiari Type I-associated syringomyelia will someday be debated.
authors.affiliation: Service de Neurochirurgie, Hôpital Pasteur, Nice, France. paquis@unice.fr
authors.forename: P
authors.initials: P
authors.lastname: Paquis
authors.forename: M
authors.initials: M
authors.lastname: Lonjon
authors.forename: M
authors.initials: M
authors.lastname: Brunet
authors.forename: J C
authors.initials: JC
authors.lastname: Lambert
authors.forename: P
authors.initials: P
authors.lastname: Grellier
mesh_terms: D000328:Adult; D001139:Arnold-Chiari Malformation / Q000145:classification / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D016569:Blepharophimosis / Q000150:complications* / Q000235:genetics / Q000473:pathology; D005260:Female; D005799:Genes, Dominant; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010375:Pedigree; D013595:Syringomyelia / Q000150:complications* / Q000175:diagnosis / Q000235:genetics