title: Protein delivery from poly(lactic-co-glycolic acid) biodegradable microspheres: release kinetics and stability issues.
abstract: In this review paper, a variety of critical factors in the PLGA microsphere formulation which might affect the release kinetic rate as well as the protein stability will be examined in detail. Three model proteins, carbonic anhydrase, bovine serum albumin, and lysozyme, which were encapsulated within PLGA microspheres by using the water/oil/water (W/O/W) double emulsion solvent evaporation method are used for the study.
authors.affiliation: Warner-Lambert Parke-Davis, Pharmaceutical Delivery Systems R&D, Morris Plains, NJ 07950, USA.
authors.forename: G
authors.initials: G
authors.lastname: Crotts
authors.forename: T G
authors.initials: TG
authors.lastname: Park
mesh_terms: D001672:Biocompatible Materials / Q000008:administration & dosage* / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004355:Drug Stability; D007700:Kinetics; D019344:Lactic Acid / Q000008:administration & dosage* / Q000737:chemistry*; D008863:Microspheres; D011100:Polyglycolic Acid / Q000008:administration & dosage* / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000008:administration & dosage* / Q000737:chemistry*; D011506:Proteins / Q000008:administration & dosage* / Q000737:chemistry*; D012997:Solvents
chemical_list: D001672:Biocompatible Materials; D011108:Polymers; D011506:Proteins; D012997:Solvents; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid