[Our experience in using a synthetic prostacyclin analog in the treatment of critical ischemia of the extremities].
The authors, after examination of pharmacologic profile of Iloprost, prostacyclin synthetic analogue, report their clinical experience from January 1992 to June 1997 on 105 patients with severe ischaemia of inferior limbs. They utilize two protocols: 0.5-2 ng/kg/min x 6 hs once a day x 28 days and 1-1.5 ng/kg/min x 6 hs twice a day x 12 days. The first protocol were practise along the first 2 years; the second on following period as long as today. The results, evaluated on clinical criteria, are referred entity and time of pain remission and decrease of analgesic use, performance status improvement, increase of gear autonomy and, if present, wound healing. The incidence of amputation was 4.76% (5 pts). The authors issue that Iloprost is a conservative treatment, often alternative with amputation, giving sometimes to patients a longtime functional "restitutio ad integrum".
Centorrino
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Clinica Chirurgica Generale II, Università degli Studi di Messina.
Versaci
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Ciccolo
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Terranova
M L
ML
Panté
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Barbera
A
A
Cuzzocrea
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D
D001157:Arterial Occlusive Diseases / Q000188:drug therapy; D016638:Critical Illness; D003925:Diabetic Angiopathies / Q000188:drug therapy; D005500:Follow-Up Studies; D006801:Humans; D016285:Iloprost / Q000008:administration & dosage* / Q000009:adverse effects; D007260:Infusion Pumps; D007511:Ischemia / Q000188:drug therapy*; D007866:Leg / Q000098:blood supply*; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000009:adverse effects
D014665:Vasodilator Agents; D016285:Iloprost
La nostra esperienza sull'utilizzo dell'analogo sintetico della prostaciclina nel trattamento dell'ischemia critica degli arti.