Enteric absorption of FK 506: estimation by a block liver perfusion technique in rats.
This perfusion model enables a pharmacokinetic study of enteral absorption and hepatic metabolic rate simultaneously. FK 506 is absorbed mainly via the proximal small intestine and metabolized rapidly by the liver during single passage. These results may lead to further analyses of absorption and metabolism of FK 506 under various conditions.
Watanabe
Y
Y
Second Department of Surgery, Ehime University, Shigenobu, Japan.
Sato
M
M
Abe
Y
Y
Yamamoto
T
T
Kashu
Y
Y
Horiuchi
A
A
Hamada
Y
Y
Nakata
T
T
Lee
T
T
Kawachi
K
K
D000818:Animals; D001012:Aorta, Abdominal; D006499:Hepatic Artery; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000502:physiology*; D008099:Liver / Q000098:blood supply / Q000502:physiology*; D008297:Male; D017538:Mesenteric Artery, Superior; D008954:Models, Biological; D010477:Perfusion; D011169:Portal Vein; D051381:Rats; D017208:Rats, Wistar; D016559:Tacrolimus / Q000097:blood / Q000493:pharmacokinetics*; D014682:Vena Cava, Inferior
D016559:Tacrolimus