title: Effects of in ovo exposure to 2,3,7,8-TCDD on F1 generation adult chickens (Gallus gallus).
abstract: White Leghorn chickens (Gallus gallus) were used as surrogate species for the resident wild turkeys found on the Times Beach, Missouri, Superfund site. Parental chickens were injected with concentrations of 2,3,7,8-TCDD which modeled soil concentrations before (200 ppb) and after remediation (1ppb)[1]. Offspring were followed through development to assess alterations in reproductive maturity through the use of a four-way breeding study. F1 adult females exposed to a maternal dose of 8.6 ng/day began egg production approximately two weeks later than did F1 control adult females. By week eight, however, egg production between groups was equivalent. No differences were observed in eggshell gland estrogen or progesterone receptor levels.
authors.affiliation: Department of Environmental Toxicology, Clemson University, Pendleton, SC 29670, USA.
authors.forename: K R
authors.initials: KR
authors.lastname: Alonso
authors.forename: M M
authors.initials: MM
authors.lastname: Peden-Adams
authors.forename: J Y
authors.initials: JY
authors.lastname: Liu
authors.forename: C
authors.initials: C
authors.lastname: Charbonneau
authors.forename: D
authors.initials: D
authors.lastname: Henshel
authors.forename: R L
authors.initials: RL
authors.lastname: Dickerson
mesh_terms: D000818:Animals; D002645:Chickens; D004967:Estrogens / Q000032:analysis; D010063:Ovum / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D000072317:Polychlorinated Dibenzodioxins / Q000009:adverse effects*; D011374:Progesterone / Q000032:analysis; D012098:Reproduction / Q000187:drug effects*; D012989:Soil Pollutants / Q000009:adverse effects*
chemical_list: D004967:Estrogens; D000072317:Polychlorinated Dibenzodioxins; D012989:Soil Pollutants; D011374:Progesterone