Synthesis of N,N'-bis-substituted diimides related to tricyclo [6.2.2.0(1,6)] dodecane with an expected activity on the central nervous system.
Continuing our studies connected with the design of antipsychotic and anxiolytic agents with a reduced propensity toward extrapyramidal side-effects, the synthesis of new compounds related to 3,7-dimethyltricyclo [6.2.2.0(1,6)] dodecen-6-yl-9,10,11,12-tetracarboxydiimide was performed. The first result of the pharmacological screening test of two of synthesized compounds displayed their low affinity for the serotonin receptor site.
Turło
J
J
Katedra i Zakład Chemii Medycznej, Akademii Medycznej w Warszawie, Poland.
Suski
S
S
Zawadowski
T
T
D000818:Animals; D014150:Antipsychotic Agents / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D001933:Brain Stem / Q000187:drug effects; D007094:Imides / Q000138:chemical synthesis*; D051381:Rats; D011985:Receptors, Serotonin / Q000378:metabolism; D013329:Structure-Activity Relationship
D014150:Antipsychotic Agents; D007094:Imides; D011985:Receptors, Serotonin