The usefulness of celite-activated thromboelastography for evaluation of fibrinolysis.
OBJECTIVE
Although thromboelastography is useful for measuring both coagulability and fibrinolysis, it takes about two hours to measure all parameters including fibrinolytic rate. The present study aimed to investigate the usefulness of celite-activated thromboelastography (TEGc) to evaluate fibrinolytic status in non-cardiac surgery.


METHODS
Whole blood samples were obtained from 30 patients for non-cardiac surgery, and used for measurements of both native TEG (TEGn) and TEGc. The final concentration of 1% (w/v) celite was used for TEGc.


RESULTS
Time for measurement of the fibrinolytic rate (FR) of TEGc in patients (56.7 +/- 4.0 min) was less than half that of FR of TEGn (123.3 +/- 15.6 min) (P < 0.05), suggesting a more rapid assessment of fibrinolytic status. A linear relationship was observed between FR values of TEGc and those of TEGn (r = 0.93, P < 0.0001), suggesting the usefulness of the fibrinolytic parameter of TEGc.


CONCLUSIONS
TEGc is a useful technique for a more rapid assessment of fibrinolytic status.
Yamakage
M
M
Department of Anesthesiology, Sapporo Medical University, School of Medicine, Hokkaido, Japan. yamakage@sapmed.ac.jp
Tsujiguchi
N
N
Kohro
S
S
Tsuchida
H
H
Namiki
A
A
D000328:Adult; D000704:Analysis of Variance; D001777:Blood Coagulation / Q000502:physiology; D007692:Diatomaceous Earth / Q000627:therapeutic use*; D005342:Fibrinolysis / Q000502:physiology; D006801:Humans; D013511:Minor Surgical Procedures; D012044:Regression Analysis; D013514:Surgical Procedures, Operative; D013916:Thrombelastography / Q000379:methods*; D013997:Time Factors
D007692:Diatomaceous Earth