Blood glucose determination in normal and alloxan-diabetic rats after administration of local anesthetics containing vasoconstrictors.
Normal and alloxan-diabetic rats were injected submucously in the posterior region of the upper jaw with bupivacaine (1.28 mg/kg) containing adrenaline (0.0012 mg/kg), or lignocaine (5.14 mg/kg) containing noradrenaline (0.005 mg/kg). Blood glucose was determined at zero (before administration), 0.5, 1, 2, 3 and 4 hours after the administration of the anesthetics. Statistical analysis (ANOVA and Tukey's test, P < 0.05) showed significant differences between treatments at 1 hour in normal rats. Bupivacaine with adrenaline induced a significantly greater blood glucose level than lignocaine with noradrenaline. The effect was significant but of short duration. In alloxan-diabetic rats, anesthetics containing adrenaline or noradrenaline did not induce increased blood glucose levels.
Esmerino
L A
LA
Departamento de Ciências Fisiológicas, Faculdade de Odontologia de Piracicaba, UNICAMP, SP, Brasil.
Ranali
J
J
Rodrigues
A L
AL
D000496:Alloxan; D000704:Analysis of Variance; D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D002045:Bupivacaine / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D004837:Epinephrine / Q000494:pharmacology; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
D000779:Anesthetics, Local; D001786:Blood Glucose; D014662:Vasoconstrictor Agents; D000496:Alloxan; D008012:Lidocaine; D009638:Norepinephrine; D002045:Bupivacaine; D004837:Epinephrine