Identification of a multixenobiotic resistance mechanism in Xenopus laevis embryos.
In the '90's a membrane-associated transport protein, discovered in aquatic organisms, was considered to be expressed in response to environmental xenobiotics. Like the multidrug resistance protein found in mammalian tumor cell lines, this protein confers resistance in organisms in polluted areas by binding xenobiotics and transporting them out of the cells in an energy-dependent manner. This study investigates the expression and the activity of a P-glycoprotein (Pgp) involved in a multixenobiotic resistance mechanism (MXRM) during the early developmental stages and in tissues of adult Xenopus laevis.
Bonfanti
P
P
Dipartimento di Scienze dell'Ambiente e del Territorio, Università degli Studi di Milano, Italy.
Colombo
A
A
Camatini
M
M
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000096:biosynthesis*; D000818:Animals; D001693:Biological Transport, Active; D015153:Blotting, Western; D018432:Drug Resistance, Multiple; D004625:Embryo, Nonmammalian / Q000187:drug effects* / Q000378:metabolism; D015262:Xenobiotics / Q000633:toxicity*; D014982:Xenopus laevis
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D015262:Xenobiotics