title: Non-Acanthamoeba amebic keratitis.
abstract: OBJECTIVE
  To describe the clinical presentation and outcome of two cases with presumed non-Acanthamoeba amebic keratitis.
  
  
  METHODS
  Case reports.
  
  
  RESULTS
  Both patients presented with typical symptoms and signs of Acanthamoeba keratitis. The patients' soft contact lenses, lens cases, open solutions, and conjunctival samples were cultured. Diagnosis of non-Acanthamoeba amebic keratitis was based on the presence of keratitis and amebic growth from patients' contact lenses of the affected eyes. Amebic culture from the contralateral contact lens was negative. Vahlkampfia cysts were identified in case 1, and Naegleria cysts in case 2. Topical treatment with polyhexamethylene biguanide and propamidine resolved the keratitis in case 1. Case 2 was lost to follow-up.
  
  
  CONCLUSIONS
  Non-Acanthamoeba amebic keratitis was diagnosed in two patients based on the clinical presentation (resembling Acanthamoeba keratitis), culture of the contact lens, and response to antiamebic treatment (in one case). Keratitis associated with Naegleria contamination of contact lenses has not been previously reported.
authors.affiliation: Department of Ophthalmology, Queen's Medical Centre-University Hospital, Nottingham, United Kingdom.
authors.forename: H S
authors.initials: HS
authors.lastname: Dua
authors.forename: A
authors.initials: A
authors.lastname: Azuara-Blanco
authors.forename: M
authors.initials: M
authors.lastname: Hossain
authors.forename: J
authors.initials: J
authors.lastname: Lloyd
mesh_terms: D000293:Adolescent; D000328:Adult; D000562:Amebiasis / Q000175:diagnosis / Q000188:drug therapy / Q000469:parasitology*; D016841:Amoebida / Q000302:isolation & purification*; D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000627:therapeutic use; D003261:Contact Lenses / Q000469:parasitology*; D003937:Diagnosis, Differential; D015822:Eye Infections, Parasitic / Q000175:diagnosis / Q000188:drug therapy / Q000469:parasitology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007634:Keratitis / Q000175:diagnosis / Q000188:drug therapy / Q000469:parasitology*; D008297:Male; D009253:Naegleria / Q000302:isolation & purification; D009883:Ophthalmic Solutions
chemical_list: D000981:Antiprotozoal Agents; D009883:Ophthalmic Solutions