In vitro effect of angiotensin II on GABA release in rat hippocampus.
In rat hippocampal slices [3H]GABA release evoked by 25 mM KCI consisted of Ca2+-dependent and Ca2+-independent fractions. Angiotensin II (AngII) at a concentration of 1 microM inhibited K+-stimulated [3H]GABA release. The effect of AngII (20% inhibition) on [3H]GABA release was decreased by the addition of 0.01 mM nipecotic acid to the superfusion medium. AngII also decreased the Ca2+-independent carrier-mediated [3H]GABA release (25% inhibition at a concentration of 1 microM). Different mechanisms of the neuromodulatory action of AngII on GABA release are discussed.
Hadjiivanova
C H
CH
Institute of Physiology, Bulgarian Academy of Sciences, Sofia.
Georgiev
V
V
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D066298:In Vitro Techniques; D008274:Magnesium / Q000494:pharmacology; D008297:Male; D009557:Nipecotic Acids / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D011392:Proline / Q000031:analogs & derivatives*; D051381:Rats; D017208:Rats, Wistar; D005680:gamma-Aminobutyric Acid / Q000378:metabolism* / Q000494:pharmacology
D009557:Nipecotic Acids; D000804:Angiotensin II; C030278:nipecotic acid; D005680:gamma-Aminobutyric Acid; D011189:Potassium Chloride; D011392:Proline; C010983:homoproline; D008274:Magnesium; D002118:Calcium