Decreased membrane Mg2+ concentrations in a subgroup of hypertensives: membrane model for the pathogenesis of primary hypertension.
Intracellular Mg2+ measurements were performed in erythrocyte membranes of 18 untreated normotensive and 19 untreated essential hypertensive patients. Mg2+ concentrations were determined by atomic absorption spectroscopy using a Video 12 apparatus. The results show that in patients with essential hypertension total Mg2+ content in erythrocyte membranes was significantly decreased as compared with the control group (0.28 +/-0.05 v 0.52+/-0.15 mmol/g membrane protein; mean+/-SD, P < .001). Additionally, plasma and free intracellular Mg2+ content of lymphocytes and platelets showed no significant difference in normotensives and hypertensives. Lowered total membrane Mg2+ concentrations in a subgroup of primary hypertensives may contribute to the development of this disorder, perhaps due to different buffering or membrane transport systems.
Kisters
K
K
Medical University Policlinic Department of Hypertension and Nephrology, University of Münster, Germany.
Tepel
M
M
Spieker
C
C
Zidek
W
W
Barenbrock
M
M
Tokmak
F
F
Kosch
M
M
Hausberg
M
M
Rahn
K H
KH
D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000378:metabolism; D008214:Lymphocytes / Q000378:metabolism; D008274:Magnesium / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
D008274:Magnesium; D002118:Calcium