Pyogenic granuloma-like lesions in a patient using topical tretinoin.
A 16-year-old male developed numerous pyogenic granuloma like-lesions across his neck, chest and back after 6 weeks isotretinoin therapy for cystic acne. The isotretinoin was ceased and he was commenced on oral steroids. After 6 weeks, the lesions were almost completely healed. However, due to worsening comedonal acne, the patient was commenced on topical tretinoin cream 0.05% twice daily to his chest. He was reviewed 2 weeks later and, surprisingly, 2 new pyogenic granuloma-like lesions had developed on his chest. These lesions persisted until the topical tretinoin was ceased 3 months later.
MacKenzie-Wood
A R
AR
Skin and Cancer Foundation Australia, Darlinghurst, New South Wales.
Wood
G
G
D000152:Acne Vulgaris / Q000150:complications / Q000188:drug therapy*; D000293:Adolescent; D003875:Drug Eruptions / Q000209:etiology*; D017789:Granuloma, Pyogenic / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D015474:Isotretinoin / Q000009:adverse effects*; D007641:Keratolytic Agents / Q000009:adverse effects*; D008297:Male; D012883:Skin Ulcer / Q000139:chemically induced*
D007641:Keratolytic Agents; D015474:Isotretinoin