[Study of antiinfectious potential of recombinant tumor necrosis factor-alpha].
Tumor necrosis factor-alpha (TNF) was shown to have an antiinfectious effect on murine and rat models of viral, bacterial and parasitic infections. The effective antiinfectious dose of TNF was determined to be 10(2)-10(3) U/kg body weight. TNF, interferon, and antibiotics were demonstrated to potentiate the antibacterial effect of each. Clinical trials of TNF in the treatment of slowly progressive, latent, and chronic infections and in the emergency prevention of acute infections are advisable.
Kalinin
Iu T
IuT
Pustoshilova
N M
NM
Denisov
L A
LA
Afanas'ev
S S
SS
Marchenko
V I
VI
Vorob'ev
A A
AA
Rubal'skiĭ
O V
OV
Shcherbakov
G Ia
GIa
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000818:Animals; D001424:Bacterial Infections / Q000188:drug therapy*; D004195:Disease Models, Animal; D005500:Follow-Up Studies; D007370:Interferon Type I / Q000627:therapeutic use; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D010272:Parasitic Diseases / Q000188:drug therapy*; D051381:Rats; D011994:Recombinant Proteins; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000627:therapeutic use*; D014777:Virus Diseases / Q000188:drug therapy*
D000276:Adjuvants, Immunologic; D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha
Izucheniie antiinfekstionnogo potentiala rekombinantnogo faktora nekroza opukholi alpha.