Lower antigenecity of long-term in vitro cultured eutopic endometrial stromal cells from endometriotic patients: a possible evidence of genetic disorders in endometriosis.
In order to investigate an evidence for genetic disorders in endometriotic patients, eutopic endometrial stromal cells were cultured in vitro for more than 4 months and their antigenecities were characterized by flowcytometry. Eutopic stromal cells from 3 endometriotic patients showed lower expressions of the seven antigens (4 cytokine receptors and 3 leukocyte antigens) than the stromal cells from 5 non-endometriotic women. The preliminary results suggest a possibility that endometriotic patients have certain irreversible genetic abnormalities in the stromal cells, and suggest that endometriosis does not occur as a result in vitro unknown transient stimulation.
Tanaka
T
T
Department of Obstetrics & Gynecology, Osaka City University Medical School, Japan.
Umesaki
N
N
Ogita
S
S
D000328:Adult; D000941:Antigens / Q000032:analysis*; D002478:Cells, Cultured; D004715:Endometriosis / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D004717:Endometrium / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D017154:Stromal Cells / Q000276:immunology* / Q000473:pathology; D013997:Time Factors
D000941:Antigens