title: Plasma and urinary endothelin-1 titers and plasma von Willebrand activity in Pseudoxanthoma elasticum.
abstract: We found high endothelin-1 and von Willebrand factor plasma titers not only in two individuals (daughter and father) affected with Pseudoxanthoma elasticum but also in a young unaffected relative. These findings raise the possibility that these molecules could be the first biochemical fingerprints of this, still not clinically evident, rare inherited disorder of elastic tissue.
authors.forename: A
authors.initials: A
authors.lastname: Amadeo
authors.forename: G
authors.initials: G
authors.lastname: Bertulezzi
authors.forename: L
authors.initials: L
authors.lastname: Civelli
authors.forename: C
authors.initials: C
authors.lastname: Porta
authors.forename: M
authors.initials: M
authors.lastname: Moroni
mesh_terms: D000328:Adult; D015415:Biomarkers; D019332:Endothelin-1 / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D011561:Pseudoxanthoma Elasticum / Q000097:blood* / Q000235:genetics / Q000652:urine*; D014841:von Willebrand Factor / Q000032:analysis*
chemical_list: D015415:Biomarkers; D019332:Endothelin-1; D014841:von Willebrand Factor