title: [Contribution of nuclear medicine to the diagnosis of recurrent brain tumors and cerebral radionecrosis].
abstract: The evaluation of brain tumor recurrence and therapy-induced benign changes following surgery and/or irradiation is a diagnostic challenge for imaging methods based on either morphology (cCT/MRI) or function (SPECT/PET). Current literature and the present data of our own patients demonstrate the diagnostic efficiency of IMT-SPECT and FDG-PET in the detection of recurrence and in-vivo grading. Thirty-nine patients suspected of brain tumor recurrence at follow-up were studied by FDG-PET and IMT-SPECT. Thirty-four of 39 patients showed recurrences; in 12 cases even a change in the grade of malignancy was observed. All high-grade recurrences could be confirmed by either methods. IMT-SPECT showed a higher sensitivity in detecting low-grade tumors at recurrence. In contrast to IMT-SPECT, FDG-PET supports sufficient in-vivo grading. Both methods can be used to differentiate between tumor recurrence and radionecrosis. In conclusion the results of our study demonstrate the efficiency of IMT-SPECT and FDG-PET in confirming recurrences and determining the actual tumor grade.
authors.affiliation: Abteilung für Nuklearmedizin, Radiologische Universitätsklinik, Homburg/Saar.
authors.forename: J B
authors.initials: JB
authors.lastname: Bader
authors.forename: S
authors.initials: S
authors.lastname: Samnick
authors.forename: A
authors.initials: A
authors.lastname: Schaefer
authors.forename: T
authors.initials: T
authors.lastname: Hagen
authors.forename: J R
authors.initials: JR
authors.lastname: Moringlane
authors.forename: W
authors.initials: W
authors.lastname: Feiden
authors.forename: U
authors.initials: U
authors.lastname: Piepgras
authors.forename: C M
authors.initials: CM
authors.lastname: Kirsch
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D001254:Astrocytoma / Q000000981:diagnostic imaging*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging* / Q000473:pathology; D009837:Oligodendroglioma / Q000000981:diagnostic imaging*; D011832:Radiation Injuries / Q000175:diagnosis / Q000209:etiology*; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon
vernacular_title: Beitrag der Nuklearmedizin zur Diagnostik des Hirntumorrezidivs und der zerebralen Radionekrose.