Facile and improved synthesis of 4 beta-aminopodophyllotoxin congeners.
An efficient synthesis of 4 beta-aminopodophyllotoxin from 4 beta-bromopodophyllotoxin using ammonia, and also a facile synthesis of 4 beta-amino-4'-O-demethylpodophyllotoxin from 4 beta-azidopodophyllotoxin by simultaneous azido reduction and selective demethylation at 4'-position employing chlorotrimethylsilane and sodium iodide, has been described. These are potential precursors for the various 4 beta-amino analogs of podophyllotoxin possessing DNA topoisomerase II inhibition activity.
Kamal
A
A
Indian Institute of Chemical Technology, Hyderabad, India.
Gayatri
N L
NL
Rao
N V
NV
D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis*; D011034:Podophyllotoxin / Q000138:chemical synthesis*; D059005:Topoisomerase II Inhibitors
D000972:Antineoplastic Agents, Phytogenic; D059005:Topoisomerase II Inhibitors; D011034:Podophyllotoxin