[Study of different pattern of immuno-modulatory mechanism by tonifying kidney and invigorating spleen].
OBJECTIVE
To observe the acting pattern on the immune system by tonifying the Kidney (TK).


METHODS
Three composite recipes were used on the 7- and 14-day corticosterone rat model to study the effect of recipes on the different pattern of immuno-modulatory and neuroendocrinological systems.


RESULTS
The immune system of Invigorate the Spleen(IS) group was well protected in either 7-day or 14-day experiment, without any effect of IS recipe acting on the neuroendocrine system, it suggested that IS recipe might have direct action on immune system, while TK group with no effect on neuroendocrine-immune (NEI) system in 7-day experiment, but showed the remarkable protective effect of the whole NEI system until 14-day experiment.


CONCLUSIONS
The results indicated that TK recipe is acting on the neuro endocime system first, and then influence the immune system. It means that the action was through down pathway of NEI network.
Shen
Z Y
ZY
Huashan Hospital, Shanghai Medical University.
Cai
D F
DF
Zhang
L J
LJ
D000818:Animals; D003345:Corticosterone; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D016867:Immunocompromised Host / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology*; D008297:Male; D015213:Neuroimmunomodulation / Q000187:drug effects*; D009490:Neurosecretory Systems / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D004365:Drugs, Chinese Herbal; D003345:Corticosterone