[3H]LY341495, a highly potent, selective and novel radioligand for labeling Group II metabotropic glutamate receptors.
We report herein the synthesis and pharmacological characterization of a tritiated version of the potent and selective cyclopropyl amino acid LY341495 as a radioligand to label group II metabotropic glutamate receptors in rat brain homogenates.
Ornstein
P L
PL
Lilly Research Laboratories, Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285-0510, USA.
Arnold
M B
MB
Bleisch
T J
TJ
Wright
R A
RA
Wheeler
W J
WJ
Schoepp
D D
DD
D000596:Amino Acids / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D018691:Excitatory Amino Acid Antagonists / Q000737:chemistry / Q000494:pharmacology*; D016548:Prosencephalon / Q000187:drug effects / Q000378:metabolism; D011869:Radioligand Assay; D051381:Rats; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors*; D014316:Tritium; D014966:Xanthenes / Q000737:chemistry / Q000494:pharmacology*
D000596:Amino Acids; D018691:Excitatory Amino Acid Antagonists; C114624:LY 341495; D018094:Receptors, Metabotropic Glutamate; D014966:Xanthenes; D014316:Tritium