Estimation of aqueous solubility for some guanine derivatives using partition coefficient and melting temperature.
Aqueous solubilities for some guanine derivatives were estimated by semiempirical equations developed by Yalkowsky and Valvani1 using the data for partition coefficient and melting temperature. It was shown that in the case of guanine derivatives examined in this study, the solubility values could not be estimated adequately by these equations.
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Faculty of Pharmacy, University of Ljubljana, Askerceva 7, 1000 Ljubljana, Slovenia.
D000212:Acyclovir / Q000737:chemistry; D000998:Antiviral Agents / Q000737:chemistry; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006147:Guanine / Q000031:analogs & derivatives* / Q000737:chemistry*; D000442:Octanols; D012995:Solubility; D012997:Solvents; D014867:Water
D000998:Antiviral Agents; D000442:Octanols; D012997:Solvents; D014867:Water; D006147:Guanine; D000212:Acyclovir