title: Inhibitory effect of potassium channel openers on proliferation of cultured rabbit aortic smooth muscle cells.
abstract: OBJECTIVE
  To study the effects of pinacidil (Pin), nicorandil (Nic), RP 49356 (RP), and lemakalim (Lem) on phenylephrine (PE)-induced proliferation of cultured rabbit aortic smooth muscle cells (ASMC).
  
  
  METHODS
  The [3H]thymidine incorporation into DNA and number of ASMC were measured.
  
  
  RESULTS
  [3H]Thymidine uptake induced by PE was markedly inhibited by Pin, Nic, RP, and Lem (0.1-10 mumol.L-1). Only RP inhibited [3H]thymidine uptake without PE-pretreatment. Cell growth induced by PE was completely inhibited by Pin.
  
  
  CONCLUSIONS
  Pin, Nic, RP, and Lem showed potent antiproliferation of ASMC.
authors.affiliation: Research Section of Pharmacology, Hu-nan Medical University, Changsha, China.
authors.forename: D H
authors.initials: DH
authors.lastname: Shi
authors.forename: Z G
authors.initials: ZG
authors.lastname: Guo
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001013:Aorta, Thoracic / Q000166:cytology; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D019806:Cromakalim / Q000494:pharmacology; D009131:Muscle, Smooth, Vascular / Q000166:cytology* / Q000378:metabolism; D020108:Nicorandil / Q000494:pharmacology; D010847:Picolines / Q000494:pharmacology; D020110:Pinacidil / Q000494:pharmacology*; D015221:Potassium Channels; D011714:Pyrans / Q000494:pharmacology; D011817:Rabbits
chemical_list: D000959:Antihypertensive Agents; D010847:Picolines; D015221:Potassium Channels; D011714:Pyrans; D019806:Cromakalim; D020108:Nicorandil; C061043:aprikalim; D020110:Pinacidil