[The effect of an extract of Baikal skullcap (Scutelleria baicalensis) on succinic acid oxidation by the brain mitochondria in rats with hypoxia].
Oxidative phosphorylation in the mitochondria of rat brain in normobaric hypercapnic hypoxia and preventive administration of Scutellaria baicalensis extract was studied by polarography. Hypoxia causes diminution of energy of the rat brain mitochondria with separation of oxidative phosphorylation and inhibition of the reactions of rapid metabolic cluster of Krebs' cycle. Scutellaria baicalensis extract prevents diminution of energy of the brain mitochondria in hypoxia, inhibits restriction of succinate dependent energy production, and preserves intactness of the mitochondrial membranes.
Saĭfutdinov
R R
RR
Laboratory of Molecular Pharmacology, Institute of Pharmacology, Tomsk Scientific Center, Russia.
Khazanov
V A
VA
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D001923:Brain Chemistry / Q000187:drug effects; D006935:Hypercapnia / Q000201:enzymology; D000860:Hypoxia / Q000201:enzymology*; D008297:Male; D008928:Mitochondria / Q000187:drug effects* / Q000201:enzymology; D010084:Oxidation-Reduction / Q000187:drug effects; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D019802:Succinic Acid / Q000378:metabolism*; D013997:Time Factors
D010936:Plant Extracts; D019802:Succinic Acid
Vliianie ékstrakta shlemnika baĭkal'skogo na okislenie iantarnoĭ kisloty mitokhondriiami golovnogo mozga krys pri gipoksii.