Promotion of second intention wound healing by emu oil lotion: comparative results with furasin, polysporin, and cortisone.
Previous studies showed that twice-daily application of emu oil lotion (mixture of emu oil/fat, vitamin E, and botanical oil) immediately after creation of full-thickness skin defects delayed wound healing 6 days later, perhaps owing to its antiinflammatory actions. If administration was delayed for 48 hours, a two-fold promotion of wound contraction, epithelialization, and infiltration of organized granulation tissue was observed. In the present study, emu oil lotion was applied to full-thickness skin defects in rodents 24 hours after surgery. Six days postoperatively, wound contraction and infiltration of fronts of epithelialized and granulation tissue were assessed. Results indicated a two-fold promotion of all of the above parameters with emu oil lotion. No such effects were exerted by pure emu oil, furasin, cortaid, or polysporin. Data obtained indicate promise for emu oil lotion as an aid in treating full-thickness skin defects if applied after the major postinflammatory stages of wound healing have transpired.
Politis
M J
MJ
Department of Medical Physiology at the University of Saskatchewan, Saskatoon, Canada.
Dmytrowich
A
A
D000818:Animals; D001414:Bacitracin / Q000627:therapeutic use; D003348:Cortisone / Q000627:therapeutic use*; D004338:Drug Combinations; D004643:Emollients / Q000627:therapeutic use*; D008297:Male; D009355:Neomycin / Q000627:therapeutic use; D009821:Oils / Q000627:therapeutic use*; D011112:Polymyxin B / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014810:Vitamin E / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects*
D004338:Drug Combinations; D004643:Emollients; D009821:Oils; D001414:Bacitracin; D014810:Vitamin E; C001816:bacitracin zinc, neomycin sulfate, polymyxin B, drug combination; D009355:Neomycin; D011112:Polymyxin B; D003348:Cortisone