Identification of the mebendazole polymorphic form present in raw materials and tablets available in South Africa.
A preformulation study of four different raw materials of mebendazole showed that three samples were polymorph C and the other polymorph A, or a mixture of form A and B. X-ray powder diffractometry and infrared spectroscopy indicated that this powder could be form B, but powder dissolution, for which a much slower dissolution was obtained, suggests polymorph A. Literature prescribes the use of polymorph C pharmaceutically, but generic manufacturers should be aware that forms other than C are still available on the market. The four mebendazole tablets currently available in South Africa were also tested and it was found that all of them contained polymorph C.
Liebenberg
W
W
Research Institute for Industrial Pharmacy, Potchefstroom University, South Africa.
Dekker
T G
TG
Lötter
A P
AP
de Villiers
M M
MM
D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D003460:Crystallization; D006801:Humans; D066298:In Vitro Techniques; D008463:Mebendazole / Q000008:administration & dosage* / Q000737:chemistry* / Q000302:isolation & purification; D010316:Particle Size; D011208:Powders; D012995:Solubility; D013019:South Africa; D013055:Spectrophotometry, Infrared; D013607:Tablets; D014961:X-Ray Diffraction
D011208:Powders; D013607:Tablets; D008463:Mebendazole