title: Benefits of exercise training in patients on continuous ambulatory peritoneal dialysis.
abstract: We examined the effects of a 12-week exercise program on the exercise tolerance, blood biochemistry, blood pressure (BP) control, cardiac function, and quality-of-life (QOL) scores in 13 patients undergoing continuous ambulatory peritoneal dialysis (CAPD; six men, seven women; mean age, 46.5+/-12.8 years; mean duration on dialysis, 4.8+/-3.8 years). The patients underwent exercise training on treadmill, bike, and arm ergometers thrice weekly. Seven CAPD patients matched for age, sex, and duration on dialysis served as controls. The mean peak aerobic capacity (VO2peak) of the exercisers increased by 16.2% after training (pre- and postexercise, 17.2+/-5.2 v 20.0+/-6.4 mL/kg/min; P=0.004). Although there were no significant changes in serum urea, creatinine, albumin, and hematocrit levels; left ventricular diastolic/systolic diameters; and ejection fraction, an increasing trend of high-density lipoproteins (HDLs) was observed in the exercisers (baseline v postexercise, 33+/-11 v 40+/-14 mg/dL; P=0.06). Twenty-four-hour ambulatory BP monitoring showed a significant increase in daytime systolic BP in the exercisers (pre- and postexercise, 142+/-26 v 157+/-22 mm Hg; P=0.003), but no significant changes could be found in the ambulatory daytime diastolic BP, nocturnal BP, and resting clinic BP. The patients' QOL improved after training, with better scores in two Kidney Disease Quality of Life scales (KDQOL): burden of kidney disease and physical functioning. Two mild and uncomplicated hypotensive episodes were reported in two patients immediately after training. No changes occurred in exercise capacity, blood biochemistry, BP profile, and QOL scores in the controls. We conclude that structured aerobic exercise is safe and can improve the exercise tolerance and QOL outcomes in CAPD patients.
authors.affiliation: Department of Medicine, Tung Wah Hospital, Hong Kong, The People's Republic of China. locy@ha.org.hk
authors.forename: C Y
authors.initials: CY
authors.lastname: Lo
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.forename: W K
authors.initials: WK
authors.lastname: Lo
authors.forename: M L
authors.initials: ML
authors.lastname: Chan
authors.forename: E
authors.initials: E
authors.lastname: So
authors.forename: S
authors.initials: S
authors.lastname: Tang
authors.forename: M C
authors.initials: MC
authors.lastname: Yuen
authors.forename: I K
authors.initials: IK
authors.lastname: Cheng
authors.forename: T M
authors.initials: TM
authors.lastname: Chan
mesh_terms: D000328:Adult; D001794:Blood Pressure; D003131:Combined Modality Therapy; D005069:Evaluation Studies as Topic; D005080:Exercise Test / Q000706:statistics & numerical data; D005081:Exercise Therapy / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000706:statistics & numerical data; D011788:Quality of Life; D012449:Safety; D018709:Statistics, Nonparametric; D013997:Time Factors