title: Non increased neuron-specific enolase concentration in cerebrospinal fluid during first febrile seizures and a year follow-up in pediatric patients.
abstract: Febrile seizures are the commonest acute neurological disorder of early childhood. Studies suggested that febrile seizures are previous acute events from a more serious neurological problem. Due to neuron-specific enolase is generally accepted as a marker for neuropathological processes in the brain, 16 pediatric patients were studied during their first seizures and a year after it. Neuron-specific enolase in cerebrospinal fluid and blood were analysed by an immune enzyme assay. Non pathological neuron-specific enolase values were obtained in both periods in the group of patients. There were no significative differences when paired series statistics test was performed with 95% of confidence. Neuron-specific enolase appears not to be a marker for febrile seizures because its concentration not be increased in cerebrospinal fluid in this group of patients.
authors.affiliation: Laboratorio Inmunología, Hospital Pediátrico San Miguel, Ciudad Habana, Cuba.
authors.forename: A J
authors.initials: AJ
authors.lastname: Dorta-Contreras
authors.forename: E
authors.initials: E
authors.lastname: Tabío-Valdés
authors.forename: A
authors.initials: A
authors.lastname: Tabío-Valdés
authors.forename: C
authors.initials: C
authors.lastname: Delgado-Fernández
authors.forename: H
authors.initials: H
authors.lastname: Reiber
mesh_terms: D002555:Cerebrospinal Fluid / Q000201:enzymology*; D002648:Child; D002675:Child, Preschool; D005500:Follow-Up Studies; D006801:Humans; D010751:Phosphopyruvate Hydratase / Q000032:analysis*; D003294:Seizures, Febrile / Q000201:enzymology*
chemical_list: D010751:Phosphopyruvate Hydratase