title: Potent inhibitors of the MAP kinase p38.
abstract: The MAP kinase p38 plays a key role in the biosynthesis of the inflammatory cytokines TNF-alpha and IL-1. We have developed a novel series of potent p38 inhibitors that could lead to new methods of treatment for inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.
authors.affiliation: R. W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Henry
authors.forename: K C
authors.initials: KC
authors.lastname: Rupert
authors.forename: J H
authors.initials: JH
authors.lastname: Dodd
authors.forename: I J
authors.initials: IJ
authors.lastname: Turchi
authors.forename: S A
authors.initials: SA
authors.lastname: Wadsworth
authors.forename: D E
authors.initials: DE
authors.lastname: Cavender
authors.forename: P H
authors.initials: PH
authors.lastname: Schafer
authors.forename: J J
authors.initials: JJ
authors.lastname: Siekierka
mesh_terms: D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology; D047908:Intracellular Signaling Peptides and Proteins; D008070:Lipopolysaccharides / Q000494:pharmacology; D020928:Mitogen-Activated Protein Kinases; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors; D011725:Pyridines / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors; D048051:p38 Mitogen-Activated Protein Kinases; D000099190:MAP-Kinase-Activated Kinase 2
chemical_list: D000893:Anti-Inflammatory Agents; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D004791:Enzyme Inhibitors; D007093:Imidazoles; D047908:Intracellular Signaling Peptides and Proteins; D008070:Lipopolysaccharides; D020928:Mitogen-Activated Protein Kinases; D017346:Protein Serine-Threonine Kinases; D011725:Pyridines; D014409:Tumor Necrosis Factor-alpha; D048051:p38 Mitogen-Activated Protein Kinases; D000099190:MAP-Kinase-Activated Kinase 2; C093642:SB 203580