title: Assignment of Ptprn2, the gene encoding receptor-type protein tyrosine phosphatase IA-2beta, a major autoantigen in insulin-dependent diabetes mellitus, to mouse chromosome region 12F.
abstract: The receptor-type protein tyrosine phosphatase IA-2beta gene (mouse gene symbol Ptprn2) encodes a major autoantigen in insulin-dependent diabetes mellitus. We physically mapped Ptprn2 by fluorescence in situ hybridization to band F of mouse chromosome 12, a region that lacks diabetes susceptibility loci. The mapping confirms the proposed synteny of mouse 12F with band q36 of human chromosome 7.
authors.affiliation: Cell Biology and Histology, Institute of Cellular Signalling, University of Nijmegen, Nijmegen (The Netherlands).
authors.forename: A M
authors.initials: AM
authors.lastname: van den Maagdenberg
authors.forename: J T
authors.initials: JT
authors.lastname: Schepens
authors.forename: M T
authors.initials: MT
authors.lastname: Schepens
authors.forename: B
authors.initials: B
authors.lastname: Pepers
authors.forename: B
authors.initials: B
authors.lastname: Wieringa
authors.forename: A G
authors.initials: AG
authors.lastname: van Kessel
authors.forename: W J
authors.initials: WJ
authors.lastname: Hendriks
mesh_terms: D000818:Animals; D001324:Autoantigens / Q000235:genetics*; D002874:Chromosome Mapping; D018076:DNA, Complementary; D003922:Diabetes Mellitus, Type 1 / Q000201:enzymology* / Q000235:genetics / Q000276:immunology; D017404:In Situ Hybridization, Fluorescence; D051379:Mice; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017027:Protein Tyrosine Phosphatases / Q000235:genetics* / Q000276:immunology
chemical_list: D001324:Autoantigens; D018076:DNA, Complementary; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017027:Protein Tyrosine Phosphatases