title: Serum levels of soluble vascular cell adhesion molecule-1 (sVCAM-1) are elevated in advanced stages of non-Hodgkin's lymphomas.
abstract: The serum levels of soluble vascular cell adhesion molecule-1 (sVCAM-1) were measured in 116 patients with non-Hodgkin's lymphomas (NHL) tested previously for soluble intercellular adhesion molecule-1 (sICAM-1). In contrast to Hodgkin's disease and chronic lymphocytic leukaemia, the sVCAM-1 levels in NHL patients were not significantly different from the levels of healthy controls (n=31). However, sVCAM-1 was elevated in advanced stage disease, i.e. stages III+IV. Elevated serum levels of sVCAM-1 were associated with significantly poorer disease-free (p = 0.024) and overall (p = 0.02) survival. sVCAM-1 correlated poorly with other known prognostic variables (LDH, sTK and beta2m) and with sICAM-1. None of the tested markers added prognostic information for disease-free survival independently of Ann Arbor stage and B-symptoms. The expression of VCAM-1 and ICAM-1 in tumour biopsies from 15 patients representing 7 different histologies were examined and compared with the serum levels of the soluble adhesion molecules. No correlation was found between the adhesion molecule expression by vascular endothelium and the corresponding serum levels.
authors.affiliation: Department of Clinical Immunology and Transfusion Medicine, Uppsala University, Sweden.
authors.forename: I
authors.initials: I
authors.lastname: Christiansen
authors.forename: C
authors.initials: C
authors.lastname: Sundström
authors.forename: K M
authors.initials: KM
authors.lastname: Kälkner
authors.forename: J
authors.initials: J
authors.lastname: Bring
authors.forename: T H
authors.initials: TH
authors.lastname: Tötterman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D008228:Lymphoma, Non-Hodgkin / Q000097:blood* / Q000473:pathology; D008875:Middle Aged; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1