title: Prenatal diagnosis using the triple test.
abstract: METHODS
  A screening study performed on 2,803 pregnant women using the "triple test" is reported.
  
  
  RESULTS
  Nine hundred and twenty-one had a high prior risk, having > 35 years while, after the screening, only 201 women had a positive test at risk higher than 1:270, and underwent to amniocentesis. The detection rate (DR) for all abnormalities was 91% while for Down's syndrome (DS) it was 87.5% and for neural tube defects 85.5%. Foetal abnormalities were detected in 20 cases (1:10) while 181 were false positive cases (6.5%), of which 151 for DS (5.4%). False negative were observed only in 2 cases within 2,339 at term pregnancies.
  
  
  CONCLUSIONS
  The authors retain that high DR is related to the exactness of determination of gestation age calculated by scan and to the homogeneity of the examined population.
authors.affiliation: Cattedra di Genetica Umana, Università degli Studi, Chieti.
authors.forename: G
authors.initials: G
authors.lastname: Palka
authors.forename: P
authors.initials: P
authors.lastname: Guanciali Franchi
authors.forename: M
authors.initials: M
authors.lastname: Papponetti
authors.forename: J
authors.initials: J
authors.lastname: Marcuccitti
authors.forename: E
authors.initials: E
authors.lastname: Morizio
authors.forename: G
authors.initials: G
authors.lastname: Calabrese
authors.forename: L
authors.initials: L
authors.lastname: Stuppia
authors.forename: C
authors.initials: C
authors.lastname: Di Ilio
mesh_terms: D000328:Adult; D000649:Amniocentesis; D006063:Chorionic Gonadotropin / Q000032:analysis; D000013:Congenital Abnormalities / Q000175:diagnosis* / Q000517:prevention & control; D004964:Estriol / Q000097:blood; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis* / Q000517:prevention & control; D006801:Humans; D008403:Mass Screening; D011247:Pregnancy; D011256:Pregnancy Outcome; D011296:Prenatal Diagnosis / Q000379:methods*; D011379:Prognosis; D012307:Risk Factors; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D006063:Chorionic Gonadotropin; D000509:alpha-Fetoproteins; D004964:Estriol