Combinatorial chemistry of hydantoins.
Access to combinatorial chemistry of hydantoins is provided by convenient and versatile methods for the solid phase synthesis of libraries of 3,5-, 1,3- and 1,3,5-substituted hydantoins. The preparation of trisubstituted hydantoins features a Mitsunobu reaction for introduction of the substituent on N-1.
Boeijen
A
A
Department of Medicinal Chemistry, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands.
Kruijtzer
J A
JA
Liskamp
R M
RM
D019992:Databases as Topic; D015195:Drug Design; D006827:Hydantoins / Q000138:chemical synthesis* / Q000737:chemistry*; D007202:Indicators and Reagents; D008968:Molecular Conformation; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D006827:Hydantoins; D007202:Indicators and Reagents