title: Synthesis and evaluation of a novel series of phosphodiesterase IV inhibitors. A potential treatment for asthma.
abstract: The synthesis and pharmacological profile of a novel series of potent and selective phosphodiesterase type IV (PDE IV) inhibitors is described.
authors.affiliation: Chiroscience Ltd, Cambridge.
authors.forename: S C
authors.initials: SC
authors.lastname: Beasley
authors.forename: N
authors.initials: N
authors.lastname: Cooper
authors.forename: L
authors.initials: L
authors.lastname: Gowers
authors.forename: J P
authors.initials: JP
authors.lastname: Gregory
authors.forename: A F
authors.initials: AF
authors.lastname: Haughan
authors.forename: P G
authors.initials: PG
authors.lastname: Hellewell
authors.forename: D
authors.initials: D
authors.lastname: Macari
authors.forename: J
authors.initials: J
authors.lastname: Miotla
authors.forename: J G
authors.initials: JG
authors.lastname: Montana
authors.forename: T
authors.initials: T
authors.lastname: Morgan
authors.forename: R
authors.initials: R
authors.lastname: Naylor
authors.forename: K A
authors.initials: KA
authors.lastname: Runcie
authors.forename: B
authors.initials: B
authors.lastname: Tuladhar
authors.forename: J B
authors.initials: JB
authors.lastname: Warneck
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000577:Amides / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000494:pharmacology; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D004802:Eosinophilia / Q000188:drug therapy; D006168:Guinea Pigs; D010726:Phosphodiesterase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D015363:Quinolones / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D018927:Anti-Asthmatic Agents; D002264:Carboxylic Acids; D010726:Phosphodiesterase Inhibitors; D015363:Quinolones; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4