title: Development of new chromanol antagonists of leukotriene D4.
abstract: By addressing the issues of potency and metabolism in 3, a new series of LTD4 antagonists represented by (+)-26 was developed which is equipotent to clinical LTD4 antagonists Zafirlukast (1) and Pranlukast (2).
authors.affiliation: Central Research Division, Pfizer Inc., Groton, CT 06340, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Chambers
authors.forename: G W
authors.initials: GW
authors.lastname: Antognoli
authors.forename: J B
authors.initials: JB
authors.lastname: Cheng
authors.forename: A
authors.initials: A
authors.lastname: Marfat
authors.forename: J S
authors.initials: JS
authors.lastname: Pillar
authors.forename: J T
authors.initials: JT
authors.lastname: Shirley
authors.forename: J W
authors.initials: JW
authors.lastname: Watson
mesh_terms: D000818:Animals; D002839:Chromans / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D002867:Chromones / Q000494:pharmacology; D006168:Guinea Pigs; D006801:Humans; D007211:Indoles; D020024:Leukotriene Antagonists / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D017998:Leukotriene D4 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D048448:Phenylcarbamates; D011485:Protein Binding; D013449:Sulfonamides; D014105:Tosyl Compounds / Q000494:pharmacology
chemical_list: D002839:Chromans; D002867:Chromones; D007211:Indoles; D020024:Leukotriene Antagonists; D048448:Phenylcarbamates; D013449:Sulfonamides; D014105:Tosyl Compounds; D017998:Leukotriene D4; C029141:2,2,5,7,8-pentamethyl-1-hydroxychroman; C047681:pranlukast; C062735:zafirlukast