title: [Effect of nosocomial bacteremia caused by oxacillin-resistant Staphylococcus aureus on mortality and length of hospitalization].
abstract: OBJECTIVE
  To identify the attributed mortality rate of bloodstream hospital infection by Staphylococcus aureus resistant to methicillin (MRSA) and its effect on length of hospital stay.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  Hospital São Paulo da Universidade Federal de São Paulo, a 660-bed, tertiary-care teaching hospital in São Paulo, Brazil.
  
  
  METHODS
  Seventy one adults patients with hospital-acquired MRSA bacteremia diagnosed between January 1, 1991, and September 30, 1992, and 71 MRSA-free controls were matched by the following criteria: age, sex, underlying disease, surgical procedure, same risk time and admission date.
  
  
  RESULTS
  The incidence of patients with hospital sepsis by MRSA accounted for 73.22% of the patients with hospital bloodstream infection by Staphylococcus aureus. The mortality rate of the cases was 56.33 (40/71) and 11.26 (8/71) of the controls. The attributable mortality rate was 45.07% (OR = 17.0; IC 95% = 3.58-202.26; p = 0.000001). The length of hospital stay median time was of 32.55 days for the cases and 29.75 for the controls (p = 0.32).
  
  
  CONCLUSIONS
  A high level of sepsis by MRSA was observed in all the Staphylococcus aureus bacteremia. The bloodstream hospital infection by MRSA itself does provide a high level of mortality independently from the patients base disease, without however, increasing their hospital length of stay.
authors.affiliation: Serviço de Controle e Prevenção de Infecção Hospitalar e Disciplina de Doenças Infecciosas e Parasitárias, Universidade Federal de São Paulo, SP.
authors.forename: M
authors.initials: M
authors.lastname: Moreira
authors.forename: E A
authors.initials: EA
authors.lastname: Medeiros
authors.forename: A C
authors.initials: AC
authors.lastname: Pignatari
authors.forename: S B
authors.initials: SB
authors.lastname: Wey
authors.forename: D M
authors.initials: DM
authors.lastname: Cardo
mesh_terms: D000328:Adult; D016470:Bacteremia / Q000188:drug therapy / Q000401:mortality*; D016022:Case-Control Studies; D003428:Cross Infection / Q000188:drug therapy / Q000401:mortality*; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007902:Length of Stay; D008297:Male; D010068:Oxacillin / Q000627:therapeutic use*; D010403:Penicillin Resistance; D010406:Penicillins / Q000627:therapeutic use*; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000401:mortality*; D013997:Time Factors
chemical_list: D010406:Penicillins; D010068:Oxacillin
vernacular_title: Efeito da infecção hospitalar da corrente sanguínea por Staphylococcus aureus resistente à oxacilina sobre a letalidade e o tempo de hospitalização.