title: Administered activity of 99Tcm-DMSA for kidney scintigraphy in children.
abstract: Kidney scintigraphy using 99Tcm-dimercaptosuccinic acid (DMSA) is a common gamma camera investigation in paediatric patients. The present study deals with methods of calculating the activity to be administered to children. Our aim is to find a method of calculation which gives the same count density in the gamma camera images for all ages. Four different methods, based on body weight, height, body surface area and a theoretical model, are compared. The count density in the images of the kidneys was studied retrospectively in 85 patients aged between 3 weeks and 19.5 years. Fourteen young adults aged 22.0-31.9 years were also studied. Two of the calculation methods, based on body surface area and the theoretical model, showed no apparent age dependency (i.e. a constant count density was observed for all ages). The variation between individuals was similar with both methods, but only the body surface area method gave a count density comparable to that for the young adults. As the method based on body surface area is also easy to implement, this method is recommended.
authors.affiliation: Department of Radiation Physics, University of Göteborg, Sweden.
authors.forename: E
authors.initials: E
authors.lastname: Vestergren
authors.forename: L
authors.initials: L
authors.lastname: Jacobsson
authors.forename: A
authors.initials: A
authors.lastname: Lind
authors.forename: R
authors.initials: R
authors.lastname: Sixt
authors.forename: S
authors.initials: S
authors.lastname: Mattsson
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging; D001827:Body Height / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007668:Kidney / Q000000981:diagnostic imaging*; D008297:Male; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D019783:Technetium Tc 99m Dimercaptosuccinic Acid
chemical_list: D019275:Radiopharmaceuticals; D019783:Technetium Tc 99m Dimercaptosuccinic Acid