Inclusion complex formation of steroidal drugs with hydroxypropyl-beta-cyclodextrin studied by charge-transfer chromatography.
The interaction between 17 steroidal drugs and hyroxypropyl-beta-cyclodextrin (HPbetaBCD) was determined by charge-transfer chromatography and the relative strength of interaction was calculated. HPbetaCD interacted with each steroidal drugs decreasing the hydrophobicity of the guest molecules. The relative strength of interaction considerably depended on the structure of the drug molecule. Hydrophobicity parameters of drugs significantly influenced the strength of interaction indicating the involvement of hydrophobic forces in the binding of drugs to HPbetaCD. The marked influence of HPbetaCD on the hydrophobicity of drugs suggests that this interaction may modify the biological properties (adsorption, uptake, half-life etc.) of drug-HPbetaCD complexes drug resulting in modified efficacy.
Cserháti
T
T
Central Research Institute for Chemistry, Hungarian Academy of Sciences, Budapest.
Forgács
E
E
D000073738:2-Hydroxypropyl-beta-cyclodextrin; D002845:Chromatography; D003505:Cyclodextrins / Q000737:chemistry*; D015394:Molecular Structure; D012995:Solubility; D013256:Steroids / Q000737:chemistry*; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D013256:Steroids; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin