[In vitro experimental study of adriamycin-loaded chitosan drug delivery system].
Chitosan is a kind of biological material with good histocompatibility and gradual biodegradability in vivo. It has no toxicity or side-effect. For its gradual degradation, chitosan and adriamycin were mixed and formed drug delivery system (DDS). The release test of DDS and exudant of DDS in inhibiting OS-116 were examined in vitro. The results were as following: the DDS could release adriamycin in slow and stable way. The SO-116 inhidition rate of the exudant of the DDS on the 1st, 20th, 40th and 60th day was 58.11%, 36.48%, 24.32% and 21.62% respectively. It was concluded that the drug delivery system was a slow release system. It could maintain the concentration of adriamycin in a certain level. It was also suggested that the chitosan was a good carrier for slow release of chemotherapeutic drug in local therapy for postoperative treatment of bone tumor.
Zhang
Y
Y
Department of Orthopedic Surgery, Changzheng Hospital, 2nd Military Medical University, Shanghai, P.R. China.
Hou
C
C
Chen
A
A
D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D001859:Bone Neoplasms / Q000473:pathology*; D002686:Chitin / Q000031:analogs & derivatives*; D048271:Chitosan; D003692:Delayed-Action Preparations; D004317:Doxorubicin / Q000008:administration & dosage*; D004337:Drug Carriers; D016503:Drug Delivery Systems; D006801:Humans; D012516:Osteosarcoma / Q000473:pathology; D011897:Random Allocation; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000903:Antibiotics, Antineoplastic; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D002686:Chitin; D004317:Doxorubicin; D048271:Chitosan