title: Synthesis of DNA analogues with novel carboxamidomethyl phosphonamide and glycinamide internucleoside linkages.
abstract: Thymidine oligonucleotide analogues with phosphodiester bonds fully substituted by carboxamidomethyl phosphonamide, or glycinamide linkages were synthesized on a solid support, and their hybridization properties toward DNA and RNA targets were determined by Tm analysis.
authors.affiliation: Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia. eva@ibch.siobc.ras.ru
authors.forename: V A
authors.initials: VA
authors.lastname: Efimov
authors.forename: A A
authors.initials: AA
authors.lastname: Buryakova
authors.forename: O G
authors.initials: OG
authors.lastname: Chakhmakhcheva
mesh_terms: D004247:DNA / Q000737:chemistry*; D005998:Glycine / Q000031:analogs & derivatives*; D007202:Indicators and Reagents; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D063065:Organophosphonates; D013936:Thymidine / Q000031:analogs & derivatives* / Q000737:chemistry*
chemical_list: D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides; D063065:Organophosphonates; C027903:oligo (dT); C018556:glycine amide; D004247:DNA; D005998:Glycine; D013936:Thymidine