title: Reduction in HTLV-I proviral load and spontaneous lymphoproliferation in HTLV-I-associated myelopathy/tropical spastic paraparesis patients treated with humanized anti-Tac.
abstract: Human T-lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a neurological disease that results from an interaction of retroviral infection and immune activation. In this study, five doses (1 mg/kg) of humanized anti-Tac antibody were administered to 9 HAM/TSP patients at weeks 0, 2, 6, 10, and 14. Preliminary immunological studies on HAM/TSP patients treated with humanized anti-Tac indicate that there is a selective down-regulation of activated T cells and a decrease in the HTLV-I viral load in peripheral blood lymphocytes, most likely through the selective removal of HTLV-I-infected, activated CD4+ lymphocytes.
authors.affiliation: Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
authors.forename: T J
authors.initials: TJ
authors.lastname: Lehky
authors.forename: M C
authors.initials: MC
authors.lastname: Levin
authors.forename: R
authors.initials: R
authors.lastname: Kubota
authors.forename: R N
authors.initials: RN
authors.lastname: Bamford
authors.forename: A N
authors.initials: AN
authors.lastname: Flerlage
authors.forename: S S
authors.initials: SS
authors.lastname: Soldan
authors.forename: T P
authors.initials: TP
authors.lastname: Leist
authors.forename: A
authors.initials: A
authors.lastname: Xavier
authors.forename: J D
authors.initials: JD
authors.lastname: White
authors.forename: M
authors.initials: M
authors.lastname: Brown
authors.forename: T A
authors.initials: TA
authors.lastname: Fleisher
authors.forename: L E
authors.initials: LE
authors.lastname: Top
authors.forename: S
authors.initials: S
authors.lastname: Light
authors.forename: H F
authors.initials: HF
authors.lastname: McFarland
authors.forename: T A
authors.initials: TA
authors.lastname: Waldmann
authors.forename: S
authors.initials: S
authors.lastname: Jacobson
mesh_terms: D000906:Antibodies / Q000627:therapeutic use*; D001773:Blood Cells / Q000473:pathology; D002455:Cell Division / Q000502:physiology; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification*; D006801:Humans; D016130:Immunophenotyping; D016131:Lymphocyte Subsets / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D015493:Paraparesis, Tropical Spastic / Q000097:blood / Q000628:therapy* / Q000821:virology*; D011533:Proviruses / Q000302:isolation & purification*; D015375:Receptors, Interleukin-2 / Q000276:immunology*; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D000906:Antibodies; D015375:Receptors, Interleukin-2