Clinical spectrum of infections due to the newly described Actinomyces species A. turicensis, A. radingae, and A. europaeus.
Over a 7-year period, we isolated 294 Actinomyces-like organisms (ALOs) which were not clearly identifiable. Using well-defined probes coding for sequences specific for recently described Actinomyces species (A. turicensis, A. radingae, and A. europaeus), we were able to identify 128 strains. The majority belonged to the A. turicensis species. A. radingae was found only in patients with skin-related pathologies. A. europaeus was also detected in patients with urinary tract infections. The main sources of A. turicensis were genital infections, followed by skin-related and urinary tract infections. Additional clinical pictures were appendicitis, cholecystitis, ear, nose, and throat infections, and bacteremia. In a small number of patients these ALOs were found as the only pathogen. Strains of the three species were tested by two widely used biochemical identification methods. A. turicensis was easily identifiable by both these methods. We conclude that these ALOs are not infrequent pathogens and are found in a wide range of human infections. At least A. turicensis is easily identifiable by clinical diagnostic laboratories.
Sabbe
L J
LJ
Regional Lab for Public Health "Zeeland," 4460 AA Goes, The Netherlands. SSZGOES@ZEELANDNET.NL
Van De Merwe
D
D
Schouls
L
L
Bergmans
A
A
Vaneechoutte
M
M
Vandamme
P
P
D000190:Actinomyces / Q000235:genetics / Q000302:isolation & purification*; D000196:Actinomycosis / Q000382:microbiology*; D000328:Adult; D001064:Appendicitis / Q000382:microbiology; D016470:Bacteremia / Q000382:microbiology; D002764:Cholecystitis / Q000382:microbiology; D004269:DNA, Bacterial / Q000032:analysis / Q000235:genetics; D004427:Ear Diseases / Q000382:microbiology; D005260:Female; D005831:Genital Diseases, Female / Q000382:microbiology; D005832:Genital Diseases, Male / Q000382:microbiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009668:Nose Diseases / Q000382:microbiology; D009693:Nucleic Acid Hybridization; D012336:RNA, Ribosomal, 16S / Q000032:analysis / Q000235:genetics; D017192:Skin Diseases, Bacterial / Q000382:microbiology; D014552:Urinary Tract Infections / Q000382:microbiology
D004269:DNA, Bacterial; D012336:RNA, Ribosomal, 16S