title: [Histological study on the using of autogenous costal perichondrium graft to repair the cartilage of condylar process of mandible].
abstract: In order to observe the histological changes of the autogenous perichondrium graft from rib in the repair of injured articular cartilage of the condylar process of mandible, 50 rabbits were used, in which 15 were served as control. The articular cartilage with its subchondral bone were resected and an autogenous graft of costal perichondrium was sutured onto the raw surface of the condylar process, and in the controls, only the articular portion of the condylar process was resected without the application of autogenous costal perichondrium graft. The morphological changes of the newly formed cartilage during the process of its development were investigated by hiostological and autoradiog aphic techniques. The result revealed that 10 days after operation, the graft had increased in thickness and was richly populated form the proliferation of mesenchyme-like cells. Twenty to thirty days later, the chondrocytes were matured and the newly formed cartilage had covered the bony surface of mandibular condyle. At 60 days, the newly formed cartilagenous joint surface became glossy, and the morphology and arrangement of cells tended to be regular simulating the morphology of normal articular cartilage. From the experiment, it could be concluded that (1) The autogenous perichondrium graft placed on the condylar surface of mandible could form new articular cartilage which was similar in tissue morphology to the normal condylar cartilage. (2) The process of development of newly formed cartilage was similar to that of the normal cartilage. (3) The motion and loading on the joint could promote the formation of new cartilage and undergo biological reformation, gradually resulting in normal joint morphology. On this basis, the clinical application of autogenous perichondrium graft to repair injured cartilage of the condylar process of the mandible was feasible.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Medical College of Dalian University, P. R. China.
authors.forename: Z
authors.initials: Z
authors.lastname: Xie
authors.forename: W
authors.initials: W
authors.lastname: Zhao
authors.forename: X
authors.initials: X
authors.lastname: Zheng
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000473:pathology*; D005260:Female; D008297:Male; D008335:Mandibular Condyle / Q000293:injuries / Q000601:surgery*; D010521:Periosteum / Q000637:transplantation*; D011817:Rabbits; D011897:Random Allocation; D012272:Ribs / Q000637:transplantation*