Potent HIV protease inhibitors incorporating high-affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere.
Design and synthesis of a series of very potent nonpeptide HIV protease inhibitors are described. The inhibitors are derived from novel high affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere.
Ghosh
A K
AK
Department of Chemistry, University of Illinois at Chicago 60607, USA.
Kincaid
J F
JF
Cho
W
W
Walters
D E
DE
Krishnan
K
K
Hussain
K A
KA
Koo
Y
Y
Cho
H
H
Rudall
C
C
Holland
L
L
Buthod
J
J
D002460:Cell Line; D015195:Drug Design; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis*; D006801:Humans; D008024:Ligands; D008956:Models, Chemical; D019258:Saquinavir / Q000031:analogs & derivatives / Q000737:chemistry; D013449:Sulfonamides / Q000737:chemistry*
D017320:HIV Protease Inhibitors; D008024:Ligands; D013449:Sulfonamides; D019258:Saquinavir