title: Novel D-ring analogues of podophyllotoxin as potent anti-cancer agents.
abstract: Several D-ring modified analogues of podophyllotoxin were prepared viz semi-synthesis starting from naturally occurring podophyllotoxin and determined their in vitro anti-cancer activity. Most of the analogues have shown good activity towards human cancer cell lines.
authors.affiliation: Natural Products Division, Dr. Reddy's Research Foundation, Miyapur, Hyderabad, India.
authors.forename: D
authors.initials: D
authors.lastname: Subrahmanyam
authors.forename: B
authors.initials: B
authors.lastname: Renuka
authors.forename: C V
authors.initials: CV
authors.lastname: Rao
authors.forename: P S
authors.initials: PS
authors.lastname: Sagar
authors.forename: D S
authors.initials: DS
authors.lastname: Deevi
authors.forename: J M
authors.initials: JM
authors.lastname: Babu
authors.forename: K
authors.initials: K
authors.lastname: Vyas
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D011034:Podophyllotoxin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D011034:Podophyllotoxin