title: NGB 2904 and NGB 2849: two highly selective dopamine D3 receptor antagonists.
abstract: N-(4-[4-¿2, 3-dichlorophenyl¿-1-piperazinyl]butyl)-3-fluorenylcarboxamide and N-(4-[4-¿2, 3-dichlorophenyl¿-1-piperazinyl]butyl)-2-biphenylenylcarboxamide were prepared in several steps from 2,3-dichloroaniline. These compounds were identified as highly selective dopamine D3 receptor antagonists.
authors.affiliation: Department of Medicinal Chemistry, Neurogen Corporation, Branford, CT 06405, USA.
authors.forename: J
authors.initials: J
authors.lastname: Yuan
authors.forename: X
authors.initials: X
authors.lastname: Chen
authors.forename: R
authors.initials: R
authors.lastname: Brodbeck
authors.forename: R
authors.initials: R
authors.lastname: Primus
authors.forename: J
authors.initials: J
authors.lastname: Braun
authors.forename: J W
authors.initials: JW
authors.lastname: Wasley
authors.forename: A
authors.initials: A
authors.lastname: Thurkauf
mesh_terms: D000818:Animals; D016466:CHO Cells / Q000187:drug effects / Q000378:metabolism; D006224:Cricetinae; D018492:Dopamine Antagonists / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology*; D065127:Dopamine D2 Receptor Antagonists; D005449:Fluorenes / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D010879:Piperazines / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D017448:Receptors, Dopamine D2 / Q000378:metabolism; D050637:Receptors, Dopamine D3; D014162:Transfection
chemical_list: C493593:DRD3 protein, human; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; C493595:Drd3 protein, rat; D005449:Fluorenes; C116819:NGB 2849; C116818:NGB 2904; D010879:Piperazines; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3