Both nicotine and mecamylamine block dizocilpine-induced explosive jumping behavior in mice: psychiatric implications.
Dizocilpine (MK-801) administration to an outbred strain of NIH Swiss mice elicits discrete episodes of explosive jumping behavior designated as "popping." This behavior may serve as a useful preclinical paradigm for the screening of potentially novel antipsychotic medications. Both nicotine and mecamylamine, a nicotinic antagonist, dose-dependently blocked dizocilpine-induced popping. The data suggest that nicotine may be of therapeutic benefit in the treatment of schizophrenia and that some of its effects may be mediated by non-nicotinic receptors.
Tizabi
Y
Y
Department of Pharmacology, College of Medicine, Howard University, Washington, DC 20059, USA.
Mastropaolo
J
J
Park
C H
CH
Riggs
R L
RL
Powell
D
D
Rosse
R B
RB
Deutsch
S I
SI
D000818:Animals; D016291:Dizocilpine Maleate / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D008464:Mecamylamine / Q000494:pharmacology*; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009538:Nicotine / Q000494:pharmacology*; D012559:Schizophrenia / Q000188:drug therapy*
D008464:Mecamylamine; D016291:Dizocilpine Maleate; D009538:Nicotine