title: Novel quinolone derivatives as potent antibacterials.
abstract: Several 7-(3R,4R-N,N'-dialkyl diaminopyrrolidinyl)-substituted quinolones were synthesized and evaluated for antibacterial activities. 5-Amino-7-(3R,4R-N,N'-dimethyldiamino-6,8-difluoro-1,4-dihydro-1-c yclopropyl -4-oxoquinoline-3-carboxylic acid was found to have potent antibacterial activity against gram +ve organisms.
authors.affiliation: Department of Medicinal Chemistry and Drug Discovery, Dr. Reddy's Research Foundation, Hyderabad, India.
authors.forename: B B
authors.initials: BB
authors.lastname: Lohray
authors.forename: S
authors.initials: S
authors.lastname: Baskaran
authors.forename: B S
authors.initials: BS
authors.lastname: Rao
authors.forename: B
authors.initials: B
authors.lastname: Mallesham
authors.forename: K S
authors.initials: KS
authors.lastname: Bharath
authors.forename: B Y
authors.initials: BY
authors.lastname: Reddy
authors.forename: S
authors.initials: S
authors.lastname: Venkateswarlu
authors.forename: A K
authors.initials: AK
authors.lastname: Sadhukhan
authors.forename: M S
authors.initials: MS
authors.lastname: Kumar
authors.forename: H M
authors.initials: HM
authors.lastname: Sarnaik
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015363:Quinolones / Q000737:chemistry / Q000494:pharmacology*; D013045:Species Specificity; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D015363:Quinolones