Experimental equations to calculate aminoglycoside clearances through cuprophan dialyzers.
Aminoglycosides are a group of antibiotics of particular interest because of their widespread use in the treatment of infections caused by gram-negative bacteria. However, they are difficult to dose accurately because of their narrow therapeutic range and overdosing produces a large number of toxic effects. This paper describes a study carried out with the aim of ensuring the accurate administration of these antibiotics in end-stage renal disease patients undergoing hemodialysis, by developing equations which enable the dosage for individual patients to be calculated according to the dialyzer being used and the operational conditions set up during the dialysis session.
Mac-Kay
M V
MV
Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Seville, Spain.
Fernández
I P
IP
Sánchez Bursón
J L
JL
Herrero
G F
GF
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D002482:Cellulose / Q000031:analogs & derivatives; D003956:Dialysis; D016903:Drug Monitoring; D006801:Humans; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D006435:Renal Dialysis
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D002482:Cellulose; C009865:cuprammonium cellulose