Anticomplementary activity of stilbenes from medicinal plants.
The anticomplementary activity of stilbenes from medicinal plants in Korea was investigated in vitro. 3,5-Dihydroxy-4'-methoxystilbene (3) was most potent with IC50 value of 1.5 x 10(-4) M followed by rhapontigenin (4), oxyresverastrol (2), 2,3,4',5-tetrahydroxystilbene-2-O-beta-glucoside (9), rhaponticin (8), resverastrol (1), and piceid (7). The activity was found to be increased by a methylation on a hydroxy group of C-4' of 1, but decreased by further methylation on hydroxy groups of C-3 and C-5 and glucosylation on any hydroxy group of 1. Addition of hydroxy group on C-2' of 1 or C-3' of 3 was little affected on the anticomplementary activity but the activity was increased by O-glucosylation on C-2 of 1.
Oh
S R
SR
Korea Research Institute of Bioscience & Biotechnology, KIST, Taejon, Korea.
Ryu
S Y
SY
Park
S H
SH
Jung
K Y
KY
Lee
I S
IS
An
K S
KS
Lee
J J
JJ
Lee
H K
HK
D003169:Complement Inactivator Proteins / Q000494:pharmacology*; D066298:In Vitro Techniques; D010946:Plants, Medicinal / Q000737:chemistry; D013267:Stilbenes / Q000494:pharmacology*
D003169:Complement Inactivator Proteins; D013267:Stilbenes