Syntheses of D- and L-myo-inositol 1,2,4,5-tetrakisphosphate and stereoselectivity of the I(1,4,5)P3 receptor binding.
D- and L-myo-Inositol 1,2,4,5-tetrakisphosphate [D- & L-I(1,2,4,5)P4], which are analogues of D-myo-Inositol 1,4,5-trisphosphate [D-I(1,4,5)P3], a calcium mobilizing second messenger, were synthesized via resolution of the camphanate ester of a myo-inositol derivative, and the binding affinities to I(1,4,5)P3 receptor were measured.
Chung
S K
SK
Department of Chemistry, Pohang University of Science & Technology, Korea.
Shin
B G
BG
Chang
Y T
YT
Suh
B C
BC
Kim
K T
KT
D000818:Animals; D016466:CHO Cells; D015220:Calcium Channels / Q000378:metabolism*; D006224:Cricetinae; D053496:Inositol 1,4,5-Trisphosphate Receptors; D007295:Inositol Phosphates / Q000138:chemical synthesis* / Q000378:metabolism*; D008956:Models, Chemical; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D013237:Stereoisomerism
D015220:Calcium Channels; D053496:Inositol 1,4,5-Trisphosphate Receptors; D007295:Inositol Phosphates; D018160:Receptors, Cytoplasmic and Nuclear; C116606:inositol-1,2,4,5-tetrakisphosphate