Preliminary evaluation of shilajit as a suspending agent in antacid suspensions.
The efficacy of shilajit, a gummy exudate of the plant Styrax officinalis Linn (Family: Styraceae), was evaluated as a suspending agent for the formulation of antacid preparations. Shilajit produced effects on sedimentation volume similar to those produced by sodium carboxymethyl cellulose (CMC), but at lower concentrations. It induced better flocculation with a moderate increase in viscosity compared to CMC. It did not interfere with the acid-consuming capacity of the suspensions.
Shahjahan
M
M
Drug Control Authority, Safat, Kuwait.
Islam
I
I
D000536:Aluminum Hydroxide; D000863:Antacids / Q000008:administration & dosage*; D002266:Carboxymethylcellulose Sodium; D002626:Chemistry, Pharmaceutical; D005079:Excipients; D005427:Flocculation; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008276:Magnesium Hydroxide; D017633:Magnesium Silicates; D010936:Plant Extracts; D013535:Suspensions; D014783:Viscosity
D000863:Antacids; D005079:Excipients; D017633:Magnesium Silicates; D010936:Plant Extracts; D013535:Suspensions; D000536:Aluminum Hydroxide; C001671:magnesium trisilicate; D002266:Carboxymethylcellulose Sodium; D008276:Magnesium Hydroxide