Efficient synthesis of 3'-glycosylated LacNAc-based oligosaccharides.
LacNAc-based oligosaccharides, including sialyl-(2-->3)-LacNAc, dimeric sialyl-(2-->3)-LacNAc, trimeric sialyl-(2-->3)-LacNAc, beta-glucuronyl-(1-->3)-LacNAc, and 3-sulfo-beta-glucuronyl-(1-->3)-LacNAc, were synthesized efficiently from a single protected LacNAc derivative having both OH-3' and 4' unprotected.
Ding
Y
Y
Burnham Institute, La Jolla Cancer Research Center, CA 92037, USA.
Fukuda
M
M
Hindsgaul
O
O
D000606:Amino Sugars / Q000737:chemistry*; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D006031:Glycosylation; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry
D000606:Amino Sugars; D009844:Oligosaccharides; C000458:N-acetyllactosamine