Cerebrospinal fluid ferritin in glioblastoma: evidence for tumor synthesis.
Ferritin concentrations in cerebrospinal fluid (CSF) of 16 patients with glioblastoma were found to be very high (mean, 103.0 ng/mL) relative to 29 patients with viral meningitis and 20 patients with headache (mean concentrations, 5.4 and 4.3 ng/mL respectively). Simultaneous measurement of ferritin in CSF and serum revealed CSF concentrations exceeding those in serum in 11 of 16 patients with glioblastoma (CSF vs. serum ratio, 132.6%), contrasting with very low ratios in patients with meningitis (7.9%) or headache (4.9%). Ferritin was detected immunocytochemically in tumor cell cytoplasm in a resected glioblastoma. Thus, ferritin in CSF appears to be produced by glioblastoma cells, with a biologic significance requiring further investigation.
Sato
Y
Y
Department of Neurology, Futase Social Insurance Hospital, Iizuka, Japan. y-sato@ktarn.or.jp
Honda
Y
Y
Asoh
T
T
Oizumi
K
K
Ohshima
Y
Y
Honda
E
E
D000328:Adult; D000704:Analysis of Variance; D001932:Brain Neoplasms / Q000134:cerebrospinal fluid*; D005260:Female; D005293:Ferritins / Q000096:biosynthesis / Q000134:cerebrospinal fluid*; D005909:Glioblastoma / Q000134:cerebrospinal fluid*; D006261:Headache / Q000134:cerebrospinal fluid; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008587:Meningitis, Viral / Q000134:cerebrospinal fluid
D005293:Ferritins