title: Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists.
abstract: In a 3-oxo-1,4-benzodiazepine-2-acetic acid series of vitronectin receptor (alpha v beta 3) antagonists containing a benzimidazole as a novel arginine mimetic, we examined the effects of benzimidazole modifications and amide substitutions on both activity and pharmacokinetics.
authors.affiliation: Research & Development Division, SmithKline Beecham Pharmaceuticals, Collegeville, PA 19426-0989, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Keenan
authors.forename: W H
authors.initials: WH
authors.lastname: Miller
authors.forename: M A
authors.initials: MA
authors.lastname: Lago
authors.forename: F E
authors.initials: FE
authors.lastname: Ali
authors.forename: W E
authors.initials: WE
authors.lastname: Bondinell
authors.forename: J F
authors.initials: JF
authors.lastname: Callahan
authors.forename: R R
authors.initials: RR
authors.lastname: Calvo
authors.forename: R D
authors.initials: RD
authors.lastname: Cousins
authors.forename: S M
authors.initials: SM
authors.lastname: Hwang
authors.forename: D R
authors.initials: DR
authors.lastname: Jakas
authors.forename: T W
authors.initials: TW
authors.lastname: Ku
authors.forename: C
authors.initials: C
authors.lastname: Kwon
authors.forename: T T
authors.initials: TT
authors.lastname: Nguyen
authors.forename: V A
authors.initials: VA
authors.lastname: Reader
authors.forename: D J
authors.initials: DJ
authors.lastname: Rieman
authors.forename: S T
authors.initials: ST
authors.lastname: Ross
authors.forename: D T
authors.initials: DT
authors.lastname: Takata
authors.forename: I N
authors.initials: IN
authors.lastname: Uzinskas
authors.forename: C C
authors.initials: CC
authors.lastname: Yuan
authors.forename: B R
authors.initials: BR
authors.lastname: Smith
mesh_terms: D001120:Arginine; D001562:Benzimidazoles / Q000494:pharmacology*; D001569:Benzodiazepines / Q000494:pharmacology*; D019030:Receptors, Vitronectin / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
chemical_list: D001562:Benzimidazoles; D019030:Receptors, Vitronectin; D001569:Benzodiazepines; D001120:Arginine