title: Synthesis of 9-membered masked enediyne analogues possessing DNA intercalator and sugar moieties.
abstract: Syntheses of hybrid DNA cleaving molecules which have the 9-membered enediyne structure of kedarcidin with the DNA intercalator of NCS and/or the sugar moieties were accomplished. Introduction of the sugar moieties to the masked enediyne was achieved via S-alkylation of a bromoacetate derivative with a sugar-containing thiol without the need for protection of the sugar moiety.
authors.affiliation: Department of Chemical Engineering, Tokyo Institute of Technology, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: A
authors.initials: A
authors.lastname: Matsuda
authors.forename: T
authors.initials: T
authors.lastname: Doi
authors.forename: H
authors.initials: H
authors.lastname: Yamada
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis*; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis*; D002241:Carbohydrates; D003516:Cycloparaffins / Q000138:chemical synthesis*; D053281:Enediynes; D007364:Intercalating Agents / Q000138:chemical synthesis*; D009281:Naphthalenes / Q000138:chemical synthesis*
chemical_list: D000480:Alkynes; D000903:Antibiotics, Antineoplastic; D002241:Carbohydrates; D003516:Cycloparaffins; D053281:Enediynes; D007364:Intercalating Agents; D009281:Naphthalenes; C080542:kedarcidin chromophore