title: [Paroxysmal nocturnal hemoglobinuria in pregnancy].
abstract: The combination of paroxysmal nocturnal haemoglobinuria (PNH) and pregnancy occurred in three women aged 29, 31 and 35 years. One patient had a spontaneous abortion twice after which she committed suicide. In the other two the pregnancy and parturition--assisted--were without complications. However, one woman developed post-partum abdominal crises. The children were born at term and healthy. PNH is a rare form of haemolytic anemia. Pregnancy causes lethal complications in 6% of the cases of PNH, while 30% of the pregnancies end in spontaneous abortion or stillbirth. Accurate monitoring of pregnancy and the puerperium is essential.
authors.affiliation: Leids Universitair Medisch Centrum, afd. Verloskunde, Leiden.
authors.forename: J G
authors.initials: JG
authors.lastname: Lange
authors.forename: G E
authors.initials: GE
authors.lastname: Griever
authors.forename: A
authors.initials: A
authors.lastname: Brand
authors.forename: J
authors.initials: J
authors.lastname: van Roosmalen
mesh_terms: D000022:Abortion, Spontaneous; D000328:Adult; D005260:Female; D005313:Fetal Death; D006457:Hemoglobinuria, Paroxysmal / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D011241:Prednisone / Q000627:therapeutic use; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic; D011256:Pregnancy Outcome; D013405:Suicide; D013921:Thrombocytopenia / Q000150:complications; D013927:Thrombosis / Q000150:complications / Q000517:prevention & control; D016896:Treatment Outcome
chemical_list: D011241:Prednisone
vernacular_title: Paroxismale nachtelijke hemoglobinurie en zwangerschap.