title: [The antiparkinson activity of muscarinic antagonists depending on their selectivity for individual m-cholinoreceptor subtypes].
abstract: The dependence between the activity parameters of muscarine antagonists in the prevention of haloperidol catalepsy in rats and those in tests characterizing the interaction of ligands and various subtypes of m-cholinoceptors was studied. It was established by constructing the mathematical dependence that blockade of m1-cholinoceptors increases, while that of m2-cholinoceptors reduces the antiparkinsonian activity of the drugs. The activity of the muscarine antagonist pentiphan in the prevention of haloperidol-induced catalepsy in rats exceeds the activity of such traditional antiparkinsonian drugs as cyclodol and amedin.
authors.affiliation: Laboratory of Biochemistry, Institute of Toxicology, Russian Federation Ministry of Health, St. Petersburg, Russia.
authors.forename: A B
authors.initials: AB
authors.lastname: Kosmachev
authors.forename: V A
authors.initials: VA
authors.lastname: Beliaev
authors.forename: A V
authors.initials: AV
authors.lastname: Khrabrova
authors.forename: O A
authors.initials: OA
authors.lastname: Fil'ko
authors.forename: N M
authors.initials: NM
authors.lastname: Libman
mesh_terms: D000818:Animals; D000978:Antiparkinson Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002375:Catalepsy / Q000139:chemically induced / Q000517:prevention & control; D004195:Disease Models, Animal; D018492:Dopamine Antagonists; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D005260:Female; D006220:Haloperidol; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D018727:Muscarinic Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D011976:Receptors, Muscarinic / Q000145:classification / Q000187:drug effects*; D012044:Regression Analysis
chemical_list: D000978:Antiparkinson Agents; D018492:Dopamine Antagonists; D018727:Muscarinic Antagonists; D011976:Receptors, Muscarinic; D006220:Haloperidol
vernacular_title: Antiparkinsonicheskaia aktivnost' muskarinovykh antagonistov v zavisimosti ot ikh izbiratel'nosti k otdel'nym podtipam m-kholinoretseptorov.