title: Synthesis and morphological reversion activity on srctsNRK cells of pyrimidinylpropanamide antibiotics, sparsomycin, sparoxomycin A1, A2, and their analogues.
abstract: Three pyrimidinylpropanamide antibiotics sparsomycin (1), sparoxomycins A1, A2 (2, 3), and also six analogues (4-9) have been synthesized by employing asymmetric sulfide oxidation conditions as a key step. Sparsomycin (1) and its alkyl analogues (5-7) showed higher morphological reversion activities on srctsNRK cells than 2 and 3.
authors.affiliation: Biotechnology Research Center, Toyama Prefectural University, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Nakajima
authors.forename: T
authors.initials: T
authors.lastname: Enomoto
authors.forename: N
authors.initials: N
authors.lastname: Matsuura
authors.forename: M
authors.initials: M
authors.lastname: Ubukata
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis* / Q000494:pharmacology; D001358:Avian Sarcoma Viruses; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D011744:Pyrimidinones / Q000138:chemical synthesis / Q000494:pharmacology; D013033:Sparsomycin / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000903:Antibiotics, Antineoplastic; D011744:Pyrimidinones; C098364:sparoxomycin A1; D013033:Sparsomycin