title: A new indole derivative from the red alga Chondria atropurpurea. Isolation, structure determination, and anthelmintic activity.
abstract: Chondriamide C (3), a new bis(indole) amide, was isolated from the red alga Chondria atropurpurea, and its structure was established from spectroscopic data and chemical transformations. A new natural product, 3-indoleacrylamide (4), and the previously described chondriamides A and B (1, 2) and 3-indoleacrylic acid (5) were also isolated. The anthelmintic activities of compounds 1, 3, 4, and 6 (the O,N1,N1'-trimethyl derivative of compound 2) against Nippostrongylus brasiliensis in vitro were evaluated.
authors.affiliation: Facultad de Química, Universidad de la República, Av. Gral. Flores, 2124 Montevideo, Uruguay.
authors.forename: D
authors.initials: D
authors.lastname: Davyt
authors.forename: W
authors.initials: W
authors.lastname: Entz
authors.forename: R
authors.initials: R
authors.lastname: Fernandez
authors.forename: R
authors.initials: R
authors.lastname: Mariezcurrena
authors.forename: A W
authors.initials: AW
authors.lastname: Mombrú
authors.forename: J
authors.initials: J
authors.lastname: Saldaña
authors.forename: L
authors.initials: L
authors.lastname: Domínguez
authors.forename: J
authors.initials: J
authors.lastname: Coll
authors.forename: E
authors.initials: E
authors.lastname: Manta
mesh_terms: D015766:Albendazole / Q000494:pharmacology; D000818:Animals; D000871:Anthelmintics / Q000302:isolation & purification* / Q000494:pharmacology; D007211:Indoles / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009559:Nippostrongylus / Q000187:drug effects; D000461:Rhodophyta / Q000737:chemistry*; D013055:Spectrophotometry, Infrared
chemical_list: D000871:Anthelmintics; D007211:Indoles; C117238:chondriamide C; D015766:Albendazole