title: Nonpeptide glycoprotein IIb/IIIa inhibitors: substituted quinazolinediones and quinazolinones as potent fibrinogen receptor antagonists.
abstract: The synthesis and biological activity of a series of 3,6-substituted quinazolinediones and quinazolinones are described. The potent activity of these compounds as platelet aggregation inhibitors demonstrates the utility of these structures as central templates for nonpeptide RGD mimics.
authors.affiliation: Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA.
authors.forename: N J
authors.initials: NJ
authors.lastname: Liverton
authors.forename: D J
authors.initials: DJ
authors.lastname: Armstrong
authors.forename: D A
authors.initials: DA
authors.lastname: Claremon
authors.forename: D C
authors.initials: DC
authors.lastname: Remy
authors.forename: J J
authors.initials: JJ
authors.lastname: Baldwin
authors.forename: R J
authors.initials: RJ
authors.lastname: Lynch
authors.forename: G
authors.initials: G
authors.lastname: Zhang
authors.forename: R J
authors.initials: RJ
authors.lastname: Gould
mesh_terms: D006801:Humans; D066298:In Vitro Techniques; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors*; D011799:Quinazolines / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D010975:Platelet Aggregation Inhibitors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D011799:Quinazolines