Anti-AIDS agents. 32. Synthesis and anti-HIV activity of betulin derivatives.
Eleven betulin derivatives were prepared and evaluated for anti-HIV activity in H9 lymphocytes. Compound 4 was found to be the most active with EC50 and TI values of 0.00066 microM and 21,515, respectively.
Sun
I C
IC
Natural Products Laboratory, School of Pharmacy, University of North Carolina at Chapel Hill 27599-7360, USA.
Shen
J K
JK
Wang
H K
HK
Cosentino
L M
LM
Lee
K H
KH
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D015195:Drug Design; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000821:virology; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000094062:Betulinic Acid
D019380:Anti-HIV Agents; D014315:Triterpenes; C002503:betulin; D000094062:Betulinic Acid