[Studies on GBV-C infection in blood donors in four provinces of China].
Plasma antibody against GBV-C (anti-GBV-C) and GBV-C RNA were detected with enzyme immunoassay (EIA) and reverse transcription nested polymerase chain reaction (RT-nPCR) in blood donors to study the prevalence of GBV-C infection in blood donors. Positivity of anti-GBV-C was 4.92 percent in 1,200 plasma donors (59/1,200), and that of GBV-C RNA was 64.41 percent in those with positive anti-GBV-C (38/59). Positivity of anti-GBV-C was 2.86 percent in 350 whole blood donors (10/350) and that of GBV-C RNA was 60.00 percent in those with positive anti-GBV-C (6/10). Positive rate of anti-GBV-C in those who donated blood for more than 10 years was higher than in control group. It suggests that infection with GBV-C was more often in plasma and blood donors. There were blood donors with positive GBV-C RNA but normal ALT activities and those both positive in GBV-C RNA and HCV RNA. It is urgent to detect the markers of GBV-C infection in blood donors as soon as possible.
Wang
X
X
National Institute for the Control of Pharmaceutical and Biological Products, Beijing.
Hao
J
J
Zhuang
H
H
D000293:Adolescent; D000328:Adult; D001782:Blood Donors; D002681:China / Q000453:epidemiology; D018067:Flaviviridae / Q000235:genetics / Q000302:isolation & purification*; D006525:Hepatitis, Viral, Human / Q000453:epidemiology*; D006801:Humans; D010956:Plasmapheresis; D015995:Prevalence; D012367:RNA, Viral / Q000032:analysis*
D012367:RNA, Viral