title: Modeling, synthesis and biological activity of novel antifungal agents (1).
abstract: Homology modeling of candida lanosterol C-14 demethylase, synthesis and in vitro antifungal activities of cyclohexyl analogs of restricticin are described.
authors.affiliation: Department of Medicinal Chemistry, Nippon Roche Research Center, Kamakura, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tsukuda
authors.forename: Y
authors.initials: Y
authors.lastname: Shiratori
authors.forename: M
authors.initials: M
authors.lastname: Watanabe
authors.forename: H
authors.initials: H
authors.lastname: Ontsuka
authors.forename: K
authors.initials: K
authors.lastname: Hattori
authors.forename: M
authors.initials: M
authors.lastname: Shirai
authors.forename: N
authors.initials: N
authors.lastname: Shimma
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001232:Aspergillus fumigatus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D065607:Cytochrome P-450 Enzyme Inhibitors; D008826:Microbial Sensitivity Tests; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D008956:Models, Chemical; D008969:Molecular Sequence Data; D010088:Oxidoreductases / Q000037:antagonists & inhibitors; D051381:Rats; D017386:Sequence Homology, Amino Acid; D058886:Sterol 14-Demethylase
chemical_list: D000935:Antifungal Agents; D065607:Cytochrome P-450 Enzyme Inhibitors; D010088:Oxidoreductases; D058886:Sterol 14-Demethylase