title: The leader sequence of the Escherichia coli lysC gene is involved in the regulation of LysC synthesis.
abstract: In Escherichia coli and Bacillus subtilis, long leader sequences are found upstream of the lysC coding sequences which encode lysine-sensitive aspartokinase. Highly conserved regions exist between these sequences. Mutations leading to constitutive expression of the E. coli lysC gene have been localised within these conserved regions, indicating that they participate in the lysine-mediated repression mechanism of lysC expression.
authors.affiliation: Laboratoire de Chimie Bactérienne, C.N.R.S. 31, Marseille, France. patte@ibsm.cnrs-mrs.fr
authors.forename: J C
authors.initials: JC
authors.lastname: Patte
authors.forename: M
authors.initials: M
authors.lastname: Akrim
authors.forename: V
authors.initials: V
authors.lastname: Méjean
mesh_terms: D001222:Aspartate Kinase / Q000096:biosynthesis / Q000235:genetics*; D001483:Base Sequence; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics*; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D008969:Molecular Sequence Data; D012045:Regulatory Sequences, Nucleic Acid; D012689:Sequence Homology, Nucleic Acid
chemical_list: C116188:lysC aspartokinase; D001222:Aspartate Kinase