Signal transduction in wound pharmacology.
Growth factors such as TGF-beta, PDGF and FGF are thought to play important roles in wound healing. However, their biological activity and signal transduction during wound repair remain poorly understood. Growth factors are often ligands for receptor tyrosine kinase and receptor serine/threonine kinases. With recent advances in signal transduction by receptor kinases, we are beginning to understand the underlying mechanism of how growth factors may regulate cutaneous wound repair. In this paper, we will describe the pharmacological effects of growth factors on wound healing, and discuss the potential underlying signaling mechanisms. Thus, we hope to provide the basis for designing more specific therapeutics for wound healing in the near future.
Kim
W J
WJ
New York University Medical Center, NY 10016, USA.
Gittes
G K
GK
Longaker
M T
MT
D000818:Animals; D006801:Humans; D015398:Signal Transduction / Q000502:physiology*; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology*; D014947:Wounds and Injuries / Q000188:drug therapy*