title: Determinants of midterm outcome of partial left ventriculectomy in dilated cardiomyopathy.
abstract: BACKGROUND
  Partial left ventriculectomy has been proposed for treatment of severe cardiomyopathies. This study reports midterm results of this procedure in 37 patients with dilated cardiomyopathy.
  
  
  METHODS
  All patients were in New York Heart Association class III (16) or IV (21). Partial ventriculectomy was associated with mitral annuloplasty in 27 patients and with mitral replacement in 2.
  
  
  RESULTS
  There were seven operative deaths (18.9%). During a mean follow-up of 18.2+/-9.3 months, 9 more patients died. Actuarial survival was 56.7%+/-8.1% at 6 and 24 months. Analysis of factors influencing outcome showed that midterm survival was significantly affected only by myocardial cell diameter. Otherwise, functional class improved from 3.5+/-0.5 to 1.8+/-0.9 in the survivors (p < 0.001). Furthermore, left ventricular diastolic volume decreased from 523+/-207 to 380+/-148 mL (p < 0.001), and left ventricular ejection fraction increased from 17.1%+/-4.6% to 23%+/-8% (p < 0.001), whereas significant changes in cardiac index, stroke index, and pulmonary pressures were found at 1 month of follow-up. Although left ventricular diastolic volume tended to increase in the late postoperative period, left ventricular ejection fraction and hemodynamic variables did not change significantly.
  
  
  CONCLUSIONS
  Partial ventriculectomy improves left ventricular function and congestive heart failure in patients with dilated cardiomyopathy for up to 24 months of follow-up. Nevertheless, this procedure's clinical application is limited by the high mortality observed in the first postoperative months. Otherwise, new perspectives may be advised by the identification that partial ventriculectomy results seem to be influenced by compromised myocardial cells.
authors.affiliation: Instituto do Coração da Faculdade de Medicina da Universidade de São Paulo, SP, Brazil.
authors.forename: N A
authors.initials: NA
authors.lastname: Stolf
authors.forename: L F
authors.initials: LF
authors.lastname: Moreira
authors.forename: E A
authors.initials: EA
authors.lastname: Bocchi
authors.forename: M L
authors.initials: ML
authors.lastname: Higuchi
authors.forename: F
authors.initials: F
authors.lastname: Bacal
authors.forename: G
authors.initials: G
authors.lastname: Bellotti
authors.forename: A D
authors.initials: AD
authors.lastname: Jatene
mesh_terms: D000328:Adult; D000368:Aged; D002311:Cardiomyopathy, Dilated / Q000401:mortality / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000601:surgery; D006352:Heart Ventricles / Q000601:surgery*; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery; D011788:Quality of Life; D013318:Stroke Volume; D016896:Treatment Outcome