[The effect of GABA-ergic agents on the electrolyte balance under hypokinesia].
The effect of hypokinesia on the blood electrolyte balance was studied. In restricted motor activity marked deviations of the type of hypokalemia and hypercalcemia were encountered, which could promote the development of various pathological processes, including disorder of central and regional hemodynamics. GABA and piracetam had no effect on the blood serum electrolyte content in the early periods of hypokinesia. In later periods of hypokinesia both drugs under examination corrected the disorders of blood electrolyte balance induced by prolonged restriction of motor activity.
Akopian
V P
VP
Mkhitara Geratsi Erevan State Medical University, Department of Pharmacology, Republic of Armenia.
Edigarova
L V
LV
D000818:Animals; D004353:Drug Evaluation, Preclinical; D004573:Electrolytes / Q000097:blood; D018682:GABA Agents / Q000627:therapeutic use*; D018476:Hypokinesia / Q000097:blood / Q000188:drug therapy*; D008297:Male; D010889:Piracetam / Q000627:therapeutic use; D051381:Rats; D013997:Time Factors; D014882:Water-Electrolyte Balance / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000627:therapeutic use
D004573:Electrolytes; D018682:GABA Agents; D005680:gamma-Aminobutyric Acid; D010889:Piracetam
Vliianie GAMK-ergicheskikh sredstv na balans élektrolitov v usloviiakh gipokinezii.