title: [Hemopoiesis in chronic myelomonocytic leukemia].
abstract: Hemopoiesis and functional activity of monocytes were assessed in 30 patients with chronic myelomonocytic leukemia (CMML). Changes in haemogram in CMML are characterized by anemia, thrombocytopenia, normal or increased count of leukocytes with absolute monocytosis and increased count of young granulocytes. Bone marrow hemopoiesis is characterized by enhanced proliferation of cellular elements of granulocytopoiesis and monocytes, suppressed erythropoiesis and megakaryocytopoiesis. Dysplastic changes are most expressed in the erythrocytic stem cells. Studies of lysosomal enzymes showed their increased activity in monocytes of CMML patients.
authors.forename: S A
authors.initials: SA
authors.lastname: Lugovskaia
authors.forename: V T
authors.initials: VT
authors.lastname: Morozova
authors.forename: E A
authors.initials: EA
authors.lastname: Lukina
authors.forename: A S
authors.initials: AS
authors.lastname: Kozlovskaia
authors.forename: V F
authors.initials: VF
authors.lastname: Gorodnicheva
authors.forename: E P
authors.initials: EP
authors.lastname: Sysoeva
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002454:Cell Differentiation; D002455:Cell Division; D004912:Erythrocytes / Q000473:pathology; D004950:Esterases / Q000097:blood; D005260:Female; D006410:Hematopoiesis; D006801:Humans; D015477:Leukemia, Myelomonocytic, Chronic / Q000097:blood* / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010744:Phosphoric Monoester Hydrolases / Q000097:blood
chemical_list: D004950:Esterases; D010744:Phosphoric Monoester Hydrolases
vernacular_title: Gemopoéz pri khronicheskom mielomonotsitarnom leĭkoze.