title: Recurrence in meningeal hemangiopericytomas.
abstract: BACKGROUND
  Meningeal hemangiopericytomas are more aggressive than typical meningiomas, with a high rate of recurrence and distant metastases. The question of whether a correlation exists between prognosis and histologic features remains controversial.
  
  
  METHODS
  We report two cases of recurrent meningeal hemangiopericytomas. Although local growth control of the tumor was obtained by tumor removal and irradiation in a 38-year-old male patient (Case 1) with a recurrent tentorial tumor, the tumor disseminated and metastasized extracranially within a short period after treatment, leading to rapid deterioration. Another 38-year-old female patient (Case 2) with a recurrent orbital tumor had a favorable outcome after tumor removal. The Ki-67 proliferative index using the MIB-1 monoclonal antibody increased as the tumor recurred in Case 1 (2.5%, 7.9%, and 15.7%), but did not change between primary and recurrent tumors of Case 2 (4.2%, 3.1%). Immunostaining for p53 protein in Case 1 was negative at the first resection, and became positive at the second and third resections, whereas in Case 2, it was negative in both the primary and recurrent tumors.
  
  
  CONCLUSIONS
  Our results suggest that p53 protein accumulation with a high proliferative potential is a useful marker to estimate malignant progression in meningeal hemangiopericytomas.
authors.affiliation: Department of Neurosurgery, School of Medicine, Tokyo Medical and Dental University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hara
authors.forename: M
authors.initials: M
authors.lastname: Aoyagi
authors.forename: G
authors.initials: G
authors.lastname: Nagashima
authors.forename: H
authors.initials: H
authors.lastname: Wakimoto
authors.forename: T
authors.initials: T
authors.lastname: Mikami
authors.forename: S
authors.initials: S
authors.lastname: Yamamoto
authors.forename: M
authors.initials: M
authors.lastname: Tamaki
authors.forename: K
authors.initials: K
authors.lastname: Hirakawa
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000556:secondary; D018450:Disease Progression; D005260:Female; D016158:Genes, p53 / Q000235:genetics; D006393:Hemangiopericytoma / Q000737:chemistry / Q000235:genetics / Q000556:secondary*; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008577:Meningeal Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D009154:Mutation; D011237:Predictive Value of Tests; D011379:Prognosis; D013125:Spinal Neoplasms / Q000556:secondary; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*; D019043:Vascular Neoplasms / Q000556:secondary
chemical_list: D016159:Tumor Suppressor Protein p53