title: Frequent factor II G20210A mutation in idiopathic portal vein thrombosis.
abstract: OBJECTIVE
  Despite extensive investigations of portal vein thrombosis, no underlying cause is identifiable in up to 30% of patients. A recently described mutation of the prothrombin gene at nucleotide position 20210 is associated with history of venous thrombosis and was assessed in this study.
  
  
  METHODS
  We compared the frequency of factor II G20210A and factor V G1691A (factor V Leiden) mutations in 10 patients with idiopathic portal vein thrombosis, 10 patients with nonidiopathic portal vein thrombosis, 60 patients with deep vein thrombosis of the legs, and 42 control subjects.
  
  
  RESULTS
  The frequency of factor II G20210A mutation was increased in patients with idiopathic portal vein thrombosis (40.0%; confidence interval, 3.1%-76.9%) compared with controls (4.8%; confidence interval, 0%-11.5%) or patients with nonidiopathic portal vein thrombosis or deep vein thrombosis (P = 0.0001). In contrast, the frequency of the factor V G1691A mutation was similar in subjects with portal vein thrombosis and in controls but was increased in patients with deep vein thrombosis (P = 0.0001).
  
  
  CONCLUSIONS
  The factor II G20210A mutation is frequent in patients with idiopathic portal vein thrombosis and should therefore be assessed under this circumstance.
authors.affiliation: Service d'Hépato-Gastroentérologie et d'Assistance Nutritive, Hôpital de Hautepierre, France.
authors.forename: P
authors.initials: P
authors.lastname: Chamouard
authors.forename: E
authors.initials: E
authors.lastname: Pencreach
authors.forename: F
authors.initials: F
authors.lastname: Maloisel
authors.forename: L
authors.initials: L
authors.lastname: Grunebaum
authors.forename: J F
authors.initials: JF
authors.lastname: Ardizzone
authors.forename: A
authors.initials: A
authors.lastname: Meyer
authors.forename: M P
authors.initials: MP
authors.lastname: Gaub
authors.forename: J
authors.initials: J
authors.lastname: Goetz
authors.forename: R
authors.initials: R
authors.lastname: Baumann
authors.forename: B
authors.initials: B
authors.lastname: Uring-Lambert
authors.forename: S
authors.initials: S
authors.lastname: Levy
authors.forename: P
authors.initials: P
authors.lastname: Dufour
authors.forename: G
authors.initials: G
authors.lastname: Hauptmann
authors.forename: P
authors.initials: P
authors.lastname: Oudet
mesh_terms: D000328:Adult; D000368:Aged; D004591:Electrophoresis, Polyacrylamide Gel; D005165:Factor V / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011169:Portal Vein / Q000473:pathology*; D011486:Protein C / Q000378:metabolism; D011516:Prothrombin / Q000235:genetics* / Q000378:metabolism; D020246:Venous Thrombosis / Q000235:genetics*
chemical_list: D011486:Protein C; C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin