title: The familial incidence of benign paroxysmal positional vertigo.
abstract: The goal of this investigation was to determine whether there is a familial tendency in the development of benign paroxysmal positional vertigo (BPPV). We hypothesized an increased frequency of BPPV among relatives of patients with the same diagnosis. BPPV is caused by dislodged otoconia from the utricular macula floating in the semicircular canals. At least half of BPPV cases are idiopathic and most pathological associations provide no clue as to the reason otoconia become dislodged. We have noted a number of BPPV patients with family histories of BPPV, suggesting a genetic predisposition to the condition. We surveyed 120 successive BPPV patients and 120 successive dizzy patients without BPPV regarding the frequency of dizziness and BPPV (diagnosed by a physician) among family members. Patients in our group with BPPV were 5 times as likely to have relatives with BPPV compared to the dizzy control group (chi2=5.95, DF=1, p=0.015). We have demonstrated that there is a familial tendency for the occurrence of BPPV. There is nothing in our data that would distinguish between a hereditary or environmental influence in the development of the disease, however.
authors.affiliation: NJ Neuroscience Institute and Seton Hall University School of Graduate Medical Education, Edison 08818, USA.
authors.forename: M
authors.initials: M
authors.lastname: Gizzi
authors.forename: S
authors.initials: S
authors.lastname: Ayyagari
authors.forename: V
authors.initials: V
authors.lastname: Khattar
mesh_terms: D000367:Age Factors; D016009:Chi-Square Distribution; D004244:Dizziness / Q000235:genetics; D004777:Environment; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009760:Nystagmus, Physiologic; D010037:Otolithic Membrane / Q000473:pathology; D011187:Posture; D012444:Saccule and Utricle / Q000473:pathology; D012665:Semicircular Canals / Q000473:pathology; D014717:Vertigo / Q000175:diagnosis / Q000235:genetics*