title: [Fever in intensive care: keep medications in mind at all times].
abstract: In two patients, men aged 35 and 69 years admitted postoperatively to the intensive care unit, fever of unknown origin developed. One had been admitted because aspiration was suspected. He had been treated immediately with amoxicillin and clavulanic acid. The other had undergone oesophageal excision and gastric reconstruction because of oesophageal carcinoma and had been subjected to antibiotic decontamination (amphotericin B, norfloxacine en fungizone). No cause for the fever was detected, but it quickly subsided after discontinuation of the amoxicillin-clavulanic acid and the norfloxacine, respectively. When encountering fever of unknown origin in intensive care patients it is always important to think of drug fever.
authors.affiliation: Afd. Heelkunde, Academisch Ziekenhuis Rotterdam-Dijkzigt.
authors.forename: R R
authors.initials: RR
authors.lastname: Postema
authors.forename: G L
authors.initials: GL
authors.lastname: Ong
authors.forename: H A
authors.initials: HA
authors.lastname: Bruining
mesh_terms: D000328:Adult; D000368:Aged; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000009:adverse effects*; D019072:Antibiotic Prophylaxis / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology*; D004359:Drug Therapy, Combination / Q000009:adverse effects*; D004935:Esophageal Diseases / Q000601:surgery; D005335:Fever of Unknown Origin / Q000209:etiology*; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D009643:Norfloxacin / Q000009:adverse effects*; D011183:Postoperative Complications / Q000209:etiology; D013396:Suction / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D019980:Amoxicillin-Potassium Clavulanate Combination; D009643:Norfloxacin
vernacular_title: Koorts op de intensive care: denk ook altijd aan geneesmiddelen.