title: Synthesis of alpha-aryl N-adamant-1-yl nitrones and using them for spin trapping of hydroxyl radicals.
abstract: alpha-Aryl N-adamant-1-yl nitrones were synthesized and evaluated with respect to the stability of the hydroxyl radical adduct. The polarity and water solubility of nitrones were altered with changing the alpha-aryl groups. Introduction of adamantane ring instead of tert-butyl group resulted in a reasonable good stability of hydroxyl radical adduct for biological measurements.
authors.affiliation: Institute of Organic and Medicinal Chemistry, University of Pécs, Hungary.
authors.forename: C P
authors.initials: CP
authors.lastname: Sár
authors.forename: E
authors.initials: E
authors.lastname: Hideg
authors.forename: I
authors.initials: I
authors.lastname: Vass
authors.forename: K
authors.initials: K
authors.lastname: Hideg
mesh_terms: D004578:Electron Spin Resonance Spectroscopy; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000494:pharmacology; D017665:Hydroxyl Radical / Q000737:chemistry*; D009589:Nitrogen Oxides / Q000138:chemical synthesis* / Q000494:pharmacology; D013113:Spin Labels / Q000138:chemical synthesis*
chemical_list: D016166:Free Radical Scavengers; D009589:Nitrogen Oxides; D013113:Spin Labels; C015388:nitrones; D017665:Hydroxyl Radical