Pharmacokinetics of a single dose of phenylpropanolamine following oral administration at two different times of the day.
Pharmacokinetics of a single oral dose of phenylpropanolamine (CAS 154-41-6) was investigated by administering 50 mg of the drug at 10.00 and 22.00 h to 8 healthy male volunteers in a crossover design with a wash-out period of 10 days. Serum samples were analysed for phenylpropanolamine using high performance liquid chromatography. Pharmacokinetic parameters were calculated using model independent method. A significant (p < 0.05) elevation in Cmax (227.45 versus 181.98 micrograms/l) was observed following the drug administration at 22.00 h as compared to 10.00 h. These variations may be due to circadian changes in gastric pH contributing to the time dependent changes in the absorption of the drug.
Rao
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VV
University College of Pharmaceutical Sciences, Kakatiya University, Warangal, India.
Rambhau
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D
Rao
B R
BR
Srinivasu
P
P
D000284:Administration, Oral; D000328:Adult; D001067:Appetite Depressants / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid; D002940:Circadian Rhythm; D018592:Cross-Over Studies; D006207:Half-Life; D006801:Humans; D008297:Male; D014663:Nasal Decongestants / Q000008:administration & dosage / Q000493:pharmacokinetics*; D010665:Phenylpropanolamine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013056:Spectrophotometry, Ultraviolet
D001067:Appetite Depressants; D014663:Nasal Decongestants; D010665:Phenylpropanolamine