title: Synthesis of novel C7-aryl substituted pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) via pro-N10-Troc protection and Suzuki coupling.
abstract: Novel C7-aryl pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) have been synthesized via Suzuki coupling between a 7-Iodo N10-Troc-protected PBD carbinolamine and commercially available boronic acids.
authors.affiliation: CRC Gene Targeted Drug Design Research Group, School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, Hants, U.K.
authors.forename: A
authors.initials: A
authors.lastname: Guiotto
authors.forename: P W
authors.initials: PW
authors.lastname: Howard
authors.forename: P G
authors.initials: PG
authors.lastname: Baraldi
authors.forename: D E
authors.initials: DE
authors.lastname: Thurston
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis* / Q000494:pharmacology; D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000903:Antibiotics, Antineoplastic; D001569:Benzodiazepines