title: Synthesis of novel cyclic protease inhibitors using Grubbs olefin metathesis.
abstract: The unusual amino acid bishomoallylglycine was synthesized and used to form cyclic P3-P1 tripeptide inhibitors via a Grubbs olefin metathesis method. These compounds show micro- to nanomolar inhibition of Rhizopus chinensis pepsin and represent a new class of simplified aspartic protease inhibitors lacking P' residues.
authors.affiliation: University of Wisconsin-Madison School of Pharmacy 53706, USA.
authors.forename: A S
authors.initials: AS
authors.lastname: Ripka
authors.forename: R S
authors.initials: RS
authors.lastname: Bohacek
authors.forename: D H
authors.initials: DH
authors.lastname: Rich
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000475:Alkenes; D011480:Protease Inhibitors