Synthesis and pharmacokinetic profile of 3-methoxymethyl cephalosporin prodrugs.
Preparation and biological activity of prodrug-type 3-methoxymethyl cephalosporins were described. From the mixtures, R- and S-prodrugs were separated and their absolute configurations were determined, and also their bioavailability was investigated.
Jung
M H
MH
Korea Research Institute of Chemical Technology, Yusong, Taejon, Korea.
Cho
K W
KW
Park
J G
JG
Kim
Y H
YH
D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D002511:Cephalosporins / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D007408:Intestinal Absorption; D051379:Mice; D011355:Prodrugs / Q000138:chemical synthesis* / Q000493:pharmacokinetics
D002511:Cephalosporins; D011355:Prodrugs