title: [Marked airway constriction due to relapsing polychondritis].
abstract: A 40-year-old woman was admitted to our hospital presenting with dry cough, sore throat, and fever. Her right auricle was markedly swollen and her ocular conjunctiva were reddened, suggesting scleritis. A chest computed tomogram showed narrowing of the trachea due to enlarged mediastinal soft tissues. These clinical findings suggested the patient had relapsing polychondritis. A cartilage biopsy from her right auricle was taken to confirm the diagnosis. Pathological findings revealed loosening and dissolution of cartilage and infiltration of lymphocytes, which were consistent with relapsing polychondritis. Although prednisolone was given to the patient, her symptoms were not alleviated. Methylprednisolone pulse therapy and oral diaminodiphenylsulfone were added to the patient's treatment regimen. With this combination, her symptoms gradually subsided. Constriction of the airway has been cited as one of the prognostic factors in relapsing polychondritis. In view of the danger of sudden death caused by airway obstruction, close observation of the patient in this case was considered necessary.
authors.affiliation: Division of Respirology, St. Luke's International Hospital, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Usui
authors.forename: M
authors.initials: M
authors.lastname: Aoshima
authors.forename: H
authors.initials: H
authors.lastname: Nasu
authors.forename: H
authors.initials: H
authors.lastname: Tada
authors.forename: N
authors.initials: N
authors.lastname: Chonabayashi
authors.forename: M
authors.initials: M
authors.lastname: Matsusako
authors.forename: H
authors.initials: H
authors.lastname: Watanabe
authors.forename: O
authors.initials: O
authors.lastname: Doi
authors.forename: T
authors.initials: T
authors.lastname: Uekusa
authors.forename: S
authors.initials: S
authors.lastname: Saiki
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D011081:Polychondritis, Relapsing / Q000150:complications*; D014135:Tracheal Stenosis / Q000209:etiology*