Myelodysplastic syndrome with myelofibrosis and basophilia: detection of trisomy 8 in basophils by fluorescence in-situ hybridization.
We report a case of myelodysplastic syndrome (MDS) with myelofibrosis and pulmonary tuberculosis who had marked basophilia in the peripheral blood. A clonal karyotypic abnormality characterized by trisomy 8 was demonstrated by cytogenetic analysis. By correlation of cell morphology with results of fluorescence in situ hybridization using a chromosome 8 probe, we demonstrated that the basophils were not reactive but belonged to the neoplastic MDS clone.
Ma
S K
SK
Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong. eskma@hkucc.hku.hk
Chan
J C
JC
Wan
T S
TS
Chan
A Y
AY
Chan
L C
LC
D000328:Adult; D000753:Anemia, Refractory / Q000150:complications / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology*; D001491:Basophils / Q000473:pathology; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D055728:Primary Myelofibrosis / Q000150:complications / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D014314:Trisomy; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000235:genetics* / Q000503:physiopathology*