Beneficial effects of prostaglandin E1 on ischemic colitis following surgery on the abdominal aorta.
To determine the effects of prostaglandin E1 (PGE1) on the intestinal circulation, an experimental dog model of ischemic colitis following abdominal aortic reconstruction was made by ligating the inferior mesenteric artery (IMA) and the internal iliac artery, with the creation of a 50% stenosis in the superior mesenteric artery (SMA). The parameters of enteric ischemia included the blood flow of the SMA, the tissue blood flow in the small intestine and left colon, the mean stump pressure of the IMA (IMAP), and the IMAP/mean systemic blood pressure ratio. With the continuous infusion of 10 ng/kg per minute of PGE1 into the descending thoracic aorta, these values increased significantly on the seventh postoperative day compared with those on the day of operation. These results thus suggest that the continuous intraarterial infusion of PGE1 may reduce ischemic changes in the colon following abdominal aortic reconstruction.
Nakai
M
M
Second Department of Surgery (Department of Cardiovascular Surgery), Okayama University Medical School, Okayama City, Japan.
Uchida
H
H
Hanaoka
T
T
Sugiyama
S
S
Sano
S
S
Shimizu
N
N
D000527:Alprostadil / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D017544:Aortic Aneurysm, Abdominal / Q000503:physiopathology / Q000601:surgery; D017091:Colitis, Ischemic / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D004195:Disease Models, Animal; D004285:Dogs; D006439:Hemodynamics / Q000187:drug effects; D017078:Laser-Doppler Flowmetry; D017538:Mesenteric Artery, Superior / Q000502:physiology; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D011183:Postoperative Complications / Q000188:drug therapy / Q000503:physiopathology; D011184:Postoperative Period; D013152:Splanchnic Circulation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000627:therapeutic use*
D010975:Platelet Aggregation Inhibitors; D014665:Vasodilator Agents; D000527:Alprostadil