[Role of inositol triphosphate in the formation of the calcium signal in T-lymphocytes].
The mechanisms of TCR/CD3 complex and phospholipase C interaction, inositol-1,4,5-triphosphate role in both initial transient and sustained elevation of intracellular Ca2+ and in calcium oscillations driving following T cells stimulation are discussed. Data on IP3-receptors structure and localisation in lymphocytes are summarized.
Matyshevskaia
O P
OP
Taras Schevchenko Kyiv University.
D000818:Animals; D015220:Calcium Channels / Q000502:physiology; D020013:Calcium Signaling / Q000502:physiology*; D004721:Endoplasmic Reticulum / Q000502:physiology; D006801:Humans; D015544:Inositol 1,4,5-Trisphosphate / Q000502:physiology*; D008213:Lymphocyte Activation; D011948:Receptors, Antigen, T-Cell / Q000502:physiology; D013601:T-Lymphocytes / Q000502:physiology*
D015220:Calcium Channels; D011948:Receptors, Antigen, T-Cell; D015544:Inositol 1,4,5-Trisphosphate
Rol' inozitoltrifosfata v formirovanii kal'tsievogo signala v T-limfotsitakh.