title: Solid phase synthesis of oligomannopeptoids that mimic the concanavalin A-binding trimannoside.
abstract: Oligomannopeptoids from the dimer to the hexamer were produced by solid phase synthesis and their abilities to bind to concanavalin A (ConA) were assessed. The assessment indicated similarity between the oligomannopeptoids and the naturally occurring oligomannosides in the enthalpy of the binding and the valence number vs binding strength relationship, encouraging the use of the oligomannopeptoids as oligomannoside mimics.
authors.affiliation: Department of Life Science, Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yuasa
authors.forename: Y
authors.initials: Y
authors.lastname: Kamata
authors.forename: S
authors.initials: S
authors.lastname: Kurono
authors.forename: H
authors.initials: H
authors.lastname: Hashimoto
mesh_terms: D001667:Binding, Competitive; D002151:Calorimetry; D002236:Carbohydrate Conformation; D003208:Concanavalin A / Q000737:chemistry*; D019281:Dimerization; D007202:Indicators and Reagents; D007700:Kinetics; D008958:Models, Molecular; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry; D009844:Oligosaccharides / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013816:Thermodynamics
chemical_list: D007202:Indicators and Reagents; D009842:Oligopeptides; D009844:Oligosaccharides; C028569:oligomannoside; D003208:Concanavalin A