A case of pathophysiologic study in Kimura's disease: measurement of cytokines and surface analysis of eosinophils.
BACKGROUND
Kimura's disease is a rare but distinctive eosinophilic inflammatory disorder of unknown etiology; few reported case studies have focused on the immunopathologic background of this unique disease.


OBJECTIVE
To define better the immunopathogenetic features of Kimura's disease, we attempted to quantitatively analyze values of cytokines and soluble interleukin-2 receptor (sIL-2R) in peripheral blood (PB), as well as perform surface immunophenotypic analysis of eosinophils from a Japanese patient with chronic relapsing Kimura's disease.


RESULTS
Granulocyte macrophage-colony stimulating factor (GM-CSF), tumor necrosis factor-alpha (TNF-alpha) and sIL-2R were elevated, and newly expressed antigens on eosinophils CD4, CD25, and HLA-DR were found to be involved in the pathophysiology of this disorder.


CONCLUSIONS
Kimura's disease may be a disease in which activated lymphocytes release cytokines, and these released cytokines, such as GM-CSF and TNF-alpha cause eosinophil activation. These processes may be related to the pathogenesis of this disorder.
Tsukadaira
A
A
First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Kitano
K
K
Okubo
Y
Y
Horie
S
S
Ito
M
M
Momose
T
T
Takashi
S
S
Itoh
S
S
Kiyosawa
K
K
Sekiguchi
M
M
D000368:Aged; D000796:Angiolymphoid Hyperplasia with Eosinophilia / Q000097:blood / Q000503:physiopathology*; D015703:Antigens, CD / Q000097:blood; D000954:Antigens, Surface / Q000097:blood; D016207:Cytokines / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D004804:Eosinophils / Q000166:cytology / Q000276:immunology; D005434:Flow Cytometry; D006801:Humans; D039041:Integrin alpha4beta1; D016023:Integrins / Q000097:blood; D007958:Leukocyte Count; D016177:Macrophage-1 Antigen / Q000097:blood; D008297:Male; D008562:Membrane Glycoproteins; D017452:Receptors, IgG / Q000097:blood; D015375:Receptors, Interleukin-2 / Q000097:blood; D016201:Receptors, Lymphocyte Homing / Q000097:blood; D012995:Solubility; D060245:Tetraspanin 29
D015703:Antigens, CD; D000954:Antigens, Surface; C554869:CD9 protein, human; D016207:Cytokines; D039041:Integrin alpha4beta1; D016023:Integrins; D016177:Macrophage-1 Antigen; D008562:Membrane Glycoproteins; D017452:Receptors, IgG; D015375:Receptors, Interleukin-2; D016201:Receptors, Lymphocyte Homing; D060245:Tetraspanin 29