Prodrug esters of the indolocarbazole CEP-751 (KT-6587).
Prodrug esters of the indolocarbazole CEP-751 (KT-6587) were prepared with the goal of identifying water soluble, stable but cleavable forms for intravenous dosing. A dipeptide proform Lys-beta-Ala (16, CEP-2563/KT-8391) was identified for advancement to clinical trials.
Hudkins
R L
RL
Department of Chemistry, Cephalon, Inc., West Chester, PA 19380, USA.
Iqbal
M
M
Park
C H
CH
Goldstein
J
J
Herman
J L
JL
Shek
E
E
Murakata
C
C
Mallamo
J P
JP
D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D002227:Carbazoles / Q000493:pharmacokinetics / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004952:Esters; D006801:Humans; D011355:Prodrugs / Q000493:pharmacokinetics / Q000494:pharmacology*
D000970:Antineoplastic Agents; C107558:CEP 751; D002227:Carbazoles; D004952:Esters; D011355:Prodrugs