title: [The pharmacokinetics and metabolism of heptapeptide--a prospective synthetic analog of tuftsin with psychostimulating action in rats].
abstract: The pharmacokinetics of a new heptapeptide with psychotropic activity was studied in rats in experiments in vitro and in vivo by means of high-performance liquid chromatography. The heptapeptide was detected in its natural form in rat blood plasma for 7-10 min; its T1/2 exceeded that of other oligopeptides of similar structure. The structure of the main pharmacologically active heptapeptide metabolite was identified by high performance liquid chromatography; it proved to be tetrapeptide Thr-Lys-Pro-Arg (taphtsin). The heptapeptide was distributed in well vascularized organs of rats: liver > kidneys > heart.
authors.affiliation: Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: S S
authors.initials: SS
authors.lastname: Boĭko
authors.forename: V P
authors.initials: VP
authors.lastname: Zherdev
authors.forename: A A
authors.initials: AA
authors.lastname: Dvorianinov
authors.forename: S B
authors.initials: SB
authors.lastname: Seredenin
authors.forename: L Iu
authors.initials: LIu
authors.lastname: Alfeeva
authors.forename: L A
authors.initials: LA
authors.lastname: Andreeva
authors.forename: S V
authors.initials: SV
authors.lastname: Bezmenova
authors.forename: N F
authors.initials: NF
authors.lastname: Miasoedov
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D006207:Half-Life; D011619:Psychotropic Drugs / Q000032:analysis / Q000493:pharmacokinetics*; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution; D014405:Tuftsin / Q000031:analogs & derivatives* / Q000032:analysis / Q000493:pharmacokinetics*
chemical_list: D011619:Psychotropic Drugs; D014405:Tuftsin
vernacular_title: Farmakokinetika i metabolizm geptapeptida--perspektivnogo sinteticheskogo analoga taftsina s psikhostimuliruiushchim deĭstviem u krys.