The synthesis and biological activity of a novel series of diazepine MMP inhibitors.
A novel series of diazepine-based hydroxamic acid inhibitors of MMP-1, MMP-9, and MMP-13 were prepared and evaluated both in vitro and in vivo.
Levin
J I
JI
Wyeth-Ayerst Research, Pearl River, NY 10965, USA.
DiJoseph
J F
JF
Killar
L M
LM
Sung
A
A
Walter
T
T
Sharr
M A
MA
Roth
C E
CE
Skotnicki
J S
JS
Albright
J D
JD
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001381:Azepines / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D006877:Hydroxamic Acids / Q000138:chemical synthesis / Q000494:pharmacology; D020781:Matrix Metalloproteinase 1; D020780:Matrix Metalloproteinase 9; D061965:Matrix Metalloproteinase Inhibitors; D051379:Mice; D009930:Organic Chemicals; D011480:Protease Inhibitors / Q000494:pharmacology; D011719:Pyrazines; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis / Q000494:pharmacology
D000970:Antineoplastic Agents; D001381:Azepines; C097658:CGS 27023A; D004791:Enzyme Inhibitors; D006877:Hydroxamic Acids; D061965:Matrix Metalloproteinase Inhibitors; D009930:Organic Chemicals; D011480:Protease Inhibitors; D011719:Pyrazines; D013449:Sulfonamides; C113282:prinomastat; D020780:Matrix Metalloproteinase 9; D020781:Matrix Metalloproteinase 1