Masculinizing sclerosing stromal cell tumor in pregnancy: report of a case and review of the literature.
OBJECTIVE
To report a case of sclerosing stromal cell tumor of the ovary in pregnancy and to review the literature of this rare ovarian tumor.


METHODS
The patient's office record and hospital record were reviewed. Gross and microscopic pathology were reviewed by one gynecologic pathologist. A Medline literature search and literature review were performed.


RESULTS
Over eighty cases of sclerosing stromal cell tumor of the ovary have been reported in the literature since the definition of this pathologic condition in 1973. Only five cases have been reported during pregnancy and only two of these resulted in maternal virilization. This report describes severe maternal virilization with birth of a non-virilized female infant.


CONCLUSIONS
Sclerosing stromal cell tumor of the ovary can result in severe virilization via androgen production. Surgery with removal of the involved ovary is required for diagnosis and cure. Prognosis is excellent.
Duska
L R
LR
Massachusetts General Hospital, Division of Gynecologic Oncology, Boston 02114, USA.
Flynn
C
C
Goodman
A
A
D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D010051:Ovarian Neoplasms / Q000150:complications / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D010052:Ovariectomy; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D011256:Pregnancy Outcome; D011296:Prenatal Diagnosis; D018312:Sex Cord-Gonadal Stromal Tumors / Q000150:complications / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D014770:Virilism / Q000209:etiology