title: Long-term efficacy of dietary weight loss in sleep apnoea/hypopnoea syndrome.
abstract: Weight loss is associated with clinical improvement in sleep apnoea/ hypopnoea syndrome (SAHS). The aim of this study was to ascertain whether the therapeutic efficacy of dietary weight loss is maintained in the long-term. From a total of 216 overweight SAHS patients treated by only a weight reduction programme, 24 cured by this method (apnoea/hypopnoea index (AHI) at diagnosis 443+/-27.8, after weight loss 3+/-3.1) were re-evaluated after a mean (+/-SD) period of 94.3+/-27.4 months post-cure. No correlation was found between changes in AHI and body mass index experienced by each patient in the two phases of the study (diagnosis to cure and cure to long-term follow-up), r=0.29, p=0.156, demonstrating a marked intra-individual variability. Six of the 13 patients who maintained their weight presented recurrence of SAHS (AHI 40.5+/-24.1) as did eight of the 11 who had regained weight (AHI 44.3+/-23.). Weight maintenance was more frequent among patients who had continued to attend periodic appointments, 10/11 versus 3/13 (p<0.001). In conclusion, weight-loss efficacy is maintained in the long-term in some sleep apnoea/hypopnoea syndrome patients. This study indicates the need for periodic follow-up of these patients as a reinforcement for weight maintenance and for early detection of the reappearance of sleep apnoea/hypopnoea syndrome.
authors.affiliation: Serveis de Pneumologia, Hospital General Universitari Vall d'Hebron, Barcelona, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Sampol
authors.forename: X
authors.initials: X
authors.lastname: Muñoz
authors.forename: M T
authors.initials: MT
authors.lastname: Sagalés
authors.forename: S
authors.initials: S
authors.lastname: Martí
authors.forename: A
authors.initials: A
authors.lastname: Roca
authors.forename: M
authors.initials: M
authors.lastname: Dolors de la Calzada
authors.forename: P
authors.initials: P
authors.lastname: Lloberes
authors.forename: F
authors.initials: F
authors.lastname: Morell
mesh_terms: D000328:Adult; D000368:Aged; D004038:Diet, Reducing; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000628:therapy; D017286:Polysomnography; D012008:Recurrence; D012891:Sleep Apnea Syndromes / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D015431:Weight Loss