title: Disturbance of consciousness associated with hypophosphatemia in a chronically alcoholic patient.
abstract: A 69-year-old man with chronic alcoholism was admitted to our hospital due to disturbance of consciousness and oliguria. Emergency laboratory examination revealed metabolic acidosis, hypoglycemia, hyponatremia, mild liver dysfunction, acute renal failure and rhabdomyolysis. After administration of fluids and nutrients and continuous hemodiafiltration, he recovered from all signs and symptoms except for disturbance of consciousness after 7 days. Since severe hypophosphatemia persisted, we administered adequate phosphates, and then his level of consciousness normalized. We discuss the relationships among alcohol abuse, hypophosphatemia and disturbance of consciousness, and recommend that hypophosphatemia be considered a potential cause of disturbance of consciousness in alcoholic patients.
authors.affiliation: Department of Internal Medicine, Kyoto City Hospital, Kyoto.
authors.forename: Y
authors.initials: Y
authors.lastname: Funabiki
authors.forename: H
authors.initials: H
authors.lastname: Tatsukawa
authors.forename: K
authors.initials: K
authors.lastname: Ashida
authors.forename: K
authors.initials: K
authors.lastname: Matsubara
authors.forename: Y
authors.initials: Y
authors.lastname: Kubota
authors.forename: H
authors.initials: H
authors.lastname: Uwatoko
authors.forename: K
authors.initials: K
authors.lastname: Kitamura
mesh_terms: D000138:Acidosis / Q000097:blood / Q000150:complications / Q000628:therapy; D058186:Acute Kidney Injury / Q000097:blood / Q000150:complications / Q000628:therapy; D000368:Aged; D000437:Alcoholism / Q000097:blood / Q000150:complications*; D003244:Consciousness Disorders / Q000097:blood / Q000209:etiology*; D003404:Creatinine / Q000097:blood; D005500:Follow-Up Studies; D017583:Hemodiafiltration; D006801:Humans; D007003:Hypoglycemia / Q000097:blood / Q000150:complications / Q000628:therapy; D007010:Hyponatremia / Q000097:blood / Q000150:complications / Q000628:therapy; D017674:Hypophosphatemia / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D008297:Male; D009211:Myoglobin / Q000097:blood; D010710:Phosphates / Q000097:blood / Q000627:therapeutic use; D010758:Phosphorus / Q000097:blood / Q000627:therapeutic use; D012206:Rhabdomyolysis / Q000097:blood / Q000150:complications / Q000628:therapy
chemical_list: D009211:Myoglobin; D010710:Phosphates; D010758:Phosphorus; D003404:Creatinine