title: Inflammatory response to cardiopulmonary bypass.
abstract: This article reviews the roles of the contact and complement systems and of neutrophils and monocytes in the inflammatory response to cardiopulmonary bypass and open heart operation. These blood proteins and cells, together with other blood elements, produce the vasoactive and cytotoxic substances and microemboli that cause the morbidity associated with cardiopulmonary bypass and open heart operation.
authors.affiliation: Division of Cardiothoracic Surgery, Hospital of the University of Pennsylvania, Philadelphia 19104, USA.
authors.forename: L H
authors.initials: LH
authors.lastname: Edmunds
mesh_terms: D002315:Cardiopulmonary Bypass; D003167:Complement Activation / Q000276:immunology; D001026:Coronary Artery Bypass; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D009000:Monocytes / Q000276:immunology; D018375:Neutrophil Activation / Q000276:immunology; D012308:Risk Management; D018746:Systemic Inflammatory Response Syndrome / Q000276:immunology*; D014655:Vascular Resistance / Q000502:physiology
chemical_list: D018836:Inflammation Mediators