A new strong inhibitor of beta-mannosidase.
N-phenyl-carbamate of D-mannonohydroxymolactone (I) was synthesized from mannose and was shown to be the best competitive inhibitor of beta-mannosidase so far reported (Ki = 25 nM).
Therisod
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H
S.E.S.N.A.B., Pole Sciences et Technologie, Université de La Rochelle. therisod@icmo.u-psud.fr
Letourneux
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Y
Therisod
M
M
D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006860:Hydrogen Bonding; D008361:Mannosidases / Q000037:antagonists & inhibitors*; D044902:beta-Mannosidase
D004791:Enzyme Inhibitors; D008361:Mannosidases; D044902:beta-Mannosidase