[Production of tumor necrosis factor (TNF) by macrophages and T-lymphocytes of rodents as affected by acute gamma-irradiation].
TNF production in peritoneal macrophages and in splenic T cell from mice and ground-squirrels were performed after acute in vivo and in vitro doses of ionizing radiation ranging from 0.1-6 Gy. It was observed that doses in the range 0.5-6 Gy induced the increase of TNF production along with the decrease of mitogen-induced proliferation in T lymphocytes.
Novoselova
E G
EG
Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino.
Makar
V R
VR
Semiletova
N V
NV
Kolaeva
S G
SG
Sadovnikov
V B
VB
D000818:Animals; D002455:Cell Division / Q000187:drug effects / Q000528:radiation effects; D003208:Concanavalin A / Q000494:pharmacology; D005720:Gamma Rays; D017737:Macrophages, Peritoneal / Q000378:metabolism / Q000528:radiation effects*; D008297:Male; D051379:Mice; D008934:Mitogens / Q000494:pharmacology; D013154:Spleen / Q000276:immunology / Q000378:metabolism / Q000528:radiation effects*; D013601:T-Lymphocytes / Q000378:metabolism / Q000528:radiation effects*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D008934:Mitogens; D014409:Tumor Necrosis Factor-alpha; D003208:Concanavalin A
Produktsiia faktora nekroza opukholeĭ (FNO) makrofagami i T-limfotsitami gryzunov v usloviiakh ostrogo gamma-oblucheniia.