title: Molecular cloning of XNLRR-1, a Xenopus homolog of mouse neuronal leucine-rich repeat protein expressed in the developing Xenopus nervous system.
abstract: We report the isolation and characterization of a Xenopus sequence, XNLRR-1, that is closely related to a gene for mouse neuronal leucine-rich repeat protein (NLRR-1). The cDNA clone is 4179 bp long and encodes a putative transmembrane glycoprotein of 718 amino acids, containing 12 leucine-rich repeats followed by one C2-type immunoglobulin-like domain and one fibronectin type-III repeat. XNLRR-1 is transcribed mainly in the developing eye area and the ventricular zone from diencephalon to hindbrain and slightly in spinal cord in Xenopus tadpoles. The similarity of the XNLRR-1 gene to other known cell adhesion molecules, together with the expression pattern, suggests that XNLRR-1 is involved in interactions at the neuronal cell surface.
authors.affiliation: Department of Life Sciences (Biology), Graduate School of Arts and Sciences, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Hayata
authors.forename: T
authors.initials: T
authors.lastname: Uochi
authors.forename: M
authors.initials: M
authors.lastname: Asashima
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D003001:Cloning, Molecular; D003175:Complement C2; D018076:DNA, Complementary / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification; D004027:Diencephalon / Q000737:chemistry / Q000196:embryology; D004625:Embryo, Nonmammalian / Q000737:chemistry / Q000378:metabolism; D005123:Eye / Q000737:chemistry / Q000196:embryology; D005353:Fibronectins; D018507:Gene Expression Regulation, Developmental; D007136:Immunoglobulins / Q000737:chemistry; D000090263:Leucine-Rich Repeat Proteins; D008565:Membrane Proteins; D051379:Mice; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009420:Nervous System / Q000737:chemistry / Q000196:embryology / Q000378:metabolism*; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D020449:Repetitive Sequences, Amino Acid; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012249:Rhombencephalon / Q000737:chemistry / Q000196:embryology; D017386:Sequence Homology, Amino Acid; D013116:Spinal Cord / Q000737:chemistry / Q000196:embryology; D014018:Tissue Distribution; D014981:Xenopus / Q000196:embryology / Q000235:genetics*
chemical_list: D003175:Complement C2; D018076:DNA, Complementary; D005353:Fibronectins; D007136:Immunoglobulins; D000090263:Leucine-Rich Repeat Proteins; C099580:Lrrn1 protein, mouse; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D011506:Proteins; D012333:RNA, Messenger