[Intra-arterial application of the ACE inhibitor ramipril using a microperforated catheter for the prevention of neointimal proliferation after angioplasty in an animal model].
OBJECTIVE
To evaluate the safety and benefit of a high-dose local drug administration via a microporous balloon catheter to prevent neointimal formation after balloon angioplasty.


METHODS
In New Zealand white rabbits (n = 29) neointima formation was induced by balloon denudation. Additionally, the animals were fed a 0.5% cholesterol diet for 6 weeks. Directly after the denudation, local application of 1.8 mg ramipril (n = 7) or saline (n = 7) via a microporous balloon catheter was performed. Other animals (n = 7) were treated with a systemic ramipril administration. One control group were exclusively fed with a cholesterol diet (n = 8). 6 weeks after intervention the animals were sacrificed and morphometry of the vessels was performed.


RESULTS
Local administration of ramipril resulted in a non-significant reduction of 17%. The local administration mode was combined with a significant increase in neointima formation. Systemic ramipril administration resulted in a 66% reduction of plaque area.


CONCLUSIONS
The benefit of the local ramipril administration was diminished by the inherent vessel trauma. Systemic ramipril administration resulted in a significant reduction of neointimal proliferation in New Zealand white rabbits.
Kalinowski
M
M
Abteilung für Radiologische Diagnostik, Eberhard-Karls-Universität Tübingen.
Tepe
G
G
Schieber
A
A
Bruck
B
B
Claussen
C D
CD
Duda
S H
SH
D000800:Angioplasty, Balloon / Q000009:adverse effects*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage* / Q000627:therapeutic use; D000818:Animals; D002404:Catheterization / Q000295:instrumentation* / Q000379:methods; D002455:Cell Division; D004867:Equipment Design; D008297:Male; D011817:Rabbits; D017257:Ramipril / Q000008:administration & dosage* / Q000627:therapeutic use; D017539:Tunica Intima / Q000187:drug effects / Q000293:injuries* / Q000473:pathology
D000806:Angiotensin-Converting Enzyme Inhibitors; D017257:Ramipril
Intraarterielle Applikation des ACE-Hemmers Ramipril über mikroperforierte Katheter zur Prävention der Neointimaproliferation nach Angioplastie am Tiermodell.