title: New features of the Blocks Database servers.
abstract: Blocks are ungapped multiple sequence alignments representing conserved protein regions, and the Blocks Database consists of blocks from documented protein families. World Wide Web (http://www. blocks.fhcrc.org) and Email (blocks@blocks.fhcrc.org) servers provide tools for homology searching and for analyzing protein family relationships. New enhancements include a multiple alignment processor that extends the use of these tools to imported multiple alignments of families not present in the database and a PCR primer designer that implements a new strategy for gene isolation.
authors.affiliation: Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109-1024, USA.
authors.forename: J G
authors.initials: JG
authors.lastname: Henikoff
authors.forename: S
authors.initials: S
authors.lastname: Henikoff
authors.forename: S
authors.initials: S
authors.lastname: Pietrokovski
mesh_terms: D017931:DNA Primers / Q000235:genetics; D016208:Databases, Factual; D016247:Information Storage and Retrieval; D020407:Internet; D016133:Polymerase Chain Reaction / Q000379:methods; D011506:Proteins / Q000737:chemistry / Q000145:classification* / Q000235:genetics; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D012984:Software
chemical_list: D017931:DNA Primers; D011506:Proteins