[Effect of xinmaitong capsule on damage of lipid peroxidation in coronary heart disease patients with myocardial ischemia].
OBJECTIVE
To assess the effect of Xinmaitong Capsule (XMTC) in treating coronary heart disease(CHD).


METHODS
The superoxide dismutase(SOD) and malonyldialdehyde(MDA) levels, ST of electrocardiogram and clinical symptoms of 25 CHD patients with myocardial ischemia were observed before and after treatment with XMTC and 15 patients with Composite Danshen Tablet (CDT) were studied as controls.


RESULTS
The SOD level was significantly lower than that of normal (P < 0.001), and MDA significantly increased (P < 0.001). After treatment with XMTC, the SOD levels and ST of ECG were significantly increased (P < 0.001). In the control group, the SOD levels and ST of ECG were unchanged (P > 0.05), MDA and scores of clinical symptoms were decreased (P < 0.05, P < 0.001), but the levels of them were markedly higher than those in the XMTC group (P < 0.01).


CONCLUSIONS
Lipid peroxidation injury is closely related with the myocardial ischemia and Syndrome Differentiation of TCM, XMTC with function of supplementing Qi and activating blood circulation could resist lipid peroxidation injury.
Qiu
R X
RX
First Affiliated Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou.
Luo
Z Q
ZQ
Luo
H C
HC
D002214:Capsules; D003327:Coronary Disease / Q000097:blood* / Q000188:drug therapy; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D005894:Panax / Q000627:therapeutic use*; D008517:Phytotherapy; D010946:Plants, Medicinal; D013482:Superoxide Dismutase / Q000097:blood
D002214:Capsules; D004365:Drugs, Chinese Herbal; D008315:Malondialdehyde; D013482:Superoxide Dismutase