Nuclear migration, nucleokinesis and lissencephaly.
During the past 20 years, biologists have become used to finding that proteins first identified in simple, genetically manipulable eukaryotic organisms are conserved in higher eukaryotes. This article draws attention to the similarity between NUDF protein, which is required for nuclear migration in the filamentous fungus Aspergillus nidulans, and a mammalian homologue, LIS1, whose malfunction causes lissencephaly, a neuronal migration disease. The authors suggest that there might be an underlying similarity of mechanism between nuclear migration in the fungus and neuronal migration in the brain.
Morris
N R
NR
Dept of Pharmacology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, USA. morrisnr@rwja.umdnj.edu
Efimov
V P
VP
Xiang
X
X
D000818:Animals; D002465:Cell Movement; D002467:Cell Nucleus / Q000502:physiology*; D005656:Fungal Proteins / Q000378:metabolism*; D008869:Microtubule-Associated Proteins; D009474:Neurons / Q000502:physiology; D011506:Proteins / Q000378:metabolism*
D005656:Fungal Proteins; D008869:Microtubule-Associated Proteins; C094005:NUDC protein, Emericella nidulans; C094692:NUDF protein, Emericella nidulans; D011506:Proteins