Synthesis and pharmacological activities of 13-dehydro derivatives of primary prostaglandins.
13-Dehydro derivatives of prostaglandin E1, E2, E3, F1 alpha and F2 alpha were synthesized. Compared with natural prostaglandins, 13-dehydro analogues were found to exhibit more potent inhibitory activity against human platelet aggregation and relaxation of guinea-pig isolated trachea, while they showed less potent activity of contraction of guinea-pig isolated ileum.
Tanami
T
T
Research Center, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
Kameo
K
K
Ono
N
N
Nakagawa
T
T
Annou
S
S
Tsuboi
M
M
Tani
K
K
Okamoto
S
S
Sato
F
F
D000818:Animals; D006168:Guinea Pigs; D006801:Humans; D007082:Ileum / Q000187:drug effects / Q000502:physiology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009119:Muscle Contraction / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D011453:Prostaglandins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D010975:Platelet Aggregation Inhibitors; D011453:Prostaglandins