title: Syntheses of 1-deoxy-3-s-(1-thio-alpha-D-glucopyranosyl)-mannojirimycin and 1-deoxy-3-O-(5-thio-alpha-D-glucopyranosyl)-mannojirimycin as potential inhibitors of endo-alpha-D-mannosidase.
abstract: 1-Deoxy-3-S-(1-thio-alpha-D-glucopyranosyl)-mannojirimycin and 1-deoxy-3-O-(5-thio-alpha-D-glucopyranosyl) mannojirimycin were chemically synthesized as potential inhibitors of endo-alpha-D-mannosidase.
authors.affiliation: Burnham Institute, La Jolla Cancer Research Center, CA 92037, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Ding
authors.forename: O
authors.initials: O
authors.lastname: Hindsgaul
mesh_terms: D017485:1-Deoxynojirimycin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005960:Glucosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007202:Indicators and Reagents; D008358:Mannose; D008361:Mannosidases / Q000037:antagonists & inhibitors*; D015394:Molecular Structure; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: C116643:1-deoxy-3-O-(5-thioglucopyranosyl)mannojirimycin; C116642:1-deoxy-3-S-(1-thioglucopyranosyl)mannojirimycin; D004791:Enzyme Inhibitors; D005960:Glucosides; D006027:Glycosides; D007202:Indicators and Reagents; D010880:Piperidines; D017485:1-Deoxynojirimycin; D008361:Mannosidases; C051635:endo-alpha-D-mannosidase; D008358:Mannose