Novel antineoplastic agents with efficacy against multidrug resistant tumor cells.
A novel series of pentafluorobenzenesulfonamides has been shown to inhibit the growth of a variety of human tumor cell lines. Among the cell types against which these agents were evaluated were the multidrug resistant (MDR) cell lines MCF-7/ADR and P388/ADR. The cytotoxic activity of members of this series of compounds was not affected by the multidrug resistant pump in MCF-7/ADR or P388/ADR cells.
Medina
J C
JC
Tularik Inc., South San Francisco, CA 94080, USA.
Shan
B
B
Beckmann
H
H
Farrell
R P
RP
Clark
D L
DL
Learned
R M
RM
Roche
D
D
Li
A
A
Baichwal
V
V
Case
C
C
Baeuerle
P A
PA
Rosen
T
T
Jaen
J C
JC
D000970:Antineoplastic Agents / Q000494:pharmacology*; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D004354:Drug Screening Assays, Antitumor; D005464:Fluorobenzenes / Q000494:pharmacology; D006801:Humans; D010641:Phenotype; D013449:Sulfonamides / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D005464:Fluorobenzenes; D013449:Sulfonamides