title: Immunocytochemical study of the maxilla and maxillary sinus during human fetal development.
abstract: We quantitatively examined the distribution of the proliferating cell nuclear antigen (PCNA), which is associated with cell division, and of components of the ECMs (collagen types I and III, tenascin and osteonectin) in the immature zones at three sites: palatine, inferior and vertical surface region of the fetal human maxilla as well as the maxillary sinus (MS) at 12, 16, 20, 24, and 28 weeks gestation. The percentage of PCNA-positive cells was the highest at 16 weeks in the immature zones of maxilla. Tenascin and fibrillar collagens (collagen types I and III) were especially present in the cellular zone linked to the bone and cartilage matrices of the immature zones of the maxillary bone at 20-24 weeks gestation. The osteonectin was detected on the maxillary bone from 24 weeks. These distributions of ECMs revealed the specific and contrasting profiles of development in the human maxillary bone and might reflect the formation of paranasal sinus as MS.
authors.affiliation: Department of Anatomy, School of Dentistry at Tokyo, Nippon Dental University, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Sato
authors.forename: M
authors.initials: M
authors.lastname: Sunohara
authors.forename: A
authors.initials: A
authors.lastname: Mikami
authors.forename: K
authors.initials: K
authors.lastname: Watanabe
authors.forename: T
authors.initials: T
authors.lastname: Sato
mesh_terms: D002452:Cell Count; D003094:Collagen / Q000378:metabolism; D005314:Embryonic and Fetal Development; D005109:Extracellular Matrix / Q000378:metabolism; D005333:Fetus / Q000196:embryology*; D005865:Gestational Age; D006801:Humans; D007124:Immunoenzyme Techniques; D008437:Maxilla / Q000196:embryology* / Q000378:metabolism; D008443:Maxillary Sinus / Q000196:embryology* / Q000378:metabolism; D015676:Osteonectin / Q000378:metabolism; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D019063:Tenascin / Q000378:metabolism
chemical_list: D015676:Osteonectin; D018809:Proliferating Cell Nuclear Antigen; D019063:Tenascin; D003094:Collagen