[Effect of glucosidorum Tripterygii tororum on interleukin-6 and interleukin-8 on human peripheral mononuclear cells of healthy subjects].
OBJECTIVE
To explore the effect of glucosidorum Tripterygii tororum (GTT).


METHODS
Using different techniques of cell culture, the function of GTT in comparing with that of hydrocortison (HC) on interleukin (IL)-6 and -8 production by peripheral mononuclear cells of healthy Subjects was investigated.


RESULTS
(1) Both of GTT and HC inhibited IL-6, IL-8 production, the effect of GTT being stronger when the dosage was higher than 1 microgram/ml; (2) In the isolated cells culture, the effect of GTT was similar to that of HC, but in the whole blood culture, the effect of GTT was much weaker than that of HC.


CONCLUSIONS
(1) GTT inhibited interleukin production in a dose-dependent manner; (2) The sensitivity of interleukin to drugs was different in different culture conditions; (3) The anti-inflammatory effect of GTT was related to the interleukin inhibition, but the mechanism might be different from that of HC.
Wang
Z G
ZG
Beijing Hospital.
D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D015850:Interleukin-6 / Q000096:biosynthesis*; D016209:Interleukin-8 / Q000096:biosynthesis*; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000378:metabolism*; D029757:Tripterygium
D000893:Anti-Inflammatory Agents; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D015850:Interleukin-6; D016209:Interleukin-8; D006854:Hydrocortisone