Modulation of multidrug resistance by taxuspine C and other taxoids from Japanese yew.
Taxuspine C (1), a new taxoid from the Japanese yew Taxus cuspidata, increasing the cellular accumulation of vincristine (VCR) in multidrug-resistant tumor cells as potent as verapamil enhanced the chemotherapeutic effect of VCR in P388/VCR-bearing mice. When taxuspine C (1) was given i.p. daily at 200 mg/kg with 0.2 mg/kg VCR for 5 days, a treated/control (T/C) value of 138% was obtained. The other new taxoids, taxezopidines G (8) and H (9), from the yew also increased the VCR accumulation as potent as verapamil. These results suggest that some taxoids may be useful for overcoming multidrug resistance in tumor cells.
Kobayashi
J
J
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Hosoyama
H
H
Wang
X X
XX
Shigemori
H
H
Sudo
Y
Y
Tsuruo
T
T
D000818:Animals; D001952:Bridged-Ring Compounds / Q000737:chemistry / Q000494:pharmacology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D004357:Drug Synergism; D006801:Humans; D007939:Leukemia L1210 / Q000473:pathology; D007941:Leukemia P388 / Q000473:pathology; D051379:Mice; D010666:Phenylpropionates / Q000737:chemistry / Q000494:pharmacology*; D043823:Taxoids; D014197:Trees / Q000737:chemistry*; D014407:Tumor Cells, Cultured; D014750:Vincristine / Q000494:pharmacology*
D001952:Bridged-Ring Compounds; D010666:Phenylpropionates; D043823:Taxoids; C116728:taxuspine C; D014750:Vincristine