title: Synthesis and antibacterial activity of 2-alkoxy penems.
abstract: The phosphite mediated Oxalimide cyclization reaction was extended to 4-dithiocarbonates of N-oxalyl-2-azetidinones to synthesize 2-alkoxy penems 3. In general, the in vitro antibacterial potency of compounds 3 was weak compared to the highly potent 2-alkylthiopenems 2.
authors.affiliation: Schering-Plough Research Institute, Kenilworth, New Jersey 07033-0539, USA.
authors.forename: A
authors.initials: A
authors.lastname: Afonso
authors.forename: F
authors.initials: F
authors.lastname: Hon
authors.forename: N
authors.initials: N
authors.lastname: Fett
authors.forename: J
authors.initials: J
authors.lastname: Weinstein
authors.forename: A K
authors.initials: AK
authors.lastname: Ganguly
authors.forename: L
authors.initials: L
authors.lastname: Naples
authors.forename: R S
authors.initials: RS
authors.lastname: Hare
authors.forename: G H
authors.initials: GH
authors.lastname: Miller
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007769:Lactams; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D007769:Lactams