Pulse cyclophosphamide therapy in chronic inflammatory demyelinating polyneuropathy.
Fifteen patients with chronic inflammatory demyelinating neuropathy (CIDP) were treated with pulse intravenous cyclophosphamide (IVCY) monthly for up to 6 months. Eleven patients reached a complete remission; only one patient worsened. Complications included nausea, vomiting, anemia, and hair loss. This case series suggests that monthly IVCY is beneficial in the treatment of CIDP and warrants a controlled study.
Good
J L
JL
University of Maryland School of Medicine, Department of Neurology, Baltimore 21201, USA.
Chehrenama
M
M
Mayer
R F
RF
Koski
C L
CL
D000328:Adult; D002908:Chronic Disease; D003520:Cyclophosphamide / Q000008:administration & dosage*; D003711:Demyelinating Diseases / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D011115:Polyneuropathies / Q000188:drug therapy*; D011673:Pulsatile Flow
D007166:Immunosuppressive Agents; D003520:Cyclophosphamide