title: Solid-phase synthesis of N-substituted amidinophenoxy pyridines as factor XA inhibitors.
abstract: An arylamidine linker has been employed for the solid-phase synthesis of N-substituted amidinoaryloxypyridine analogs 2 via nucleophilic substitution on a fluoropyridyl template. Two novel N-substituted amidinoaryloxypyridine derivatives 2a and 2b were discovered via this approach.
authors.affiliation: Pharmaceuticals Discovery, Berlex Biosciences, Richmond, CA 94804, USA.
authors.forename: R
authors.initials: R
authors.lastname: Mohan
authors.forename: W
authors.initials: W
authors.lastname: Yun
authors.forename: B O
authors.initials: BO
authors.lastname: Buckman
authors.forename: A
authors.initials: A
authors.lastname: Liang
authors.forename: L
authors.initials: L
authors.lastname: Trinh
authors.forename: M M
authors.initials: MM
authors.lastname: Morrissey
mesh_terms: D065427:Factor Xa Inhibitors; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015842:Serine Proteinase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D065427:Factor Xa Inhibitors; D011725:Pyridines; D015842:Serine Proteinase Inhibitors