[Study on the inactivated vaccine of Gardnerella vaginalis of fox. VI. Experimental development of the inactivated vaccine of Gardnerella vaginalis of fox].
The aluminum hydroxide gel, propolis and oil adjuvant inactivated vaccines were developed by silecting good immunity, representing principal epidemic serotype I GVF44 of Gardnerella vaginalis of fox in civil. The results showed that the aluminum hydroxide gel vaccine in safety was better than propolis and oil adjuvant vaccines, the most optimal inactivated concentration of formalin is 0.1%. Efficient immunity doses are 4 billon bacteria/1 ml. There were on any bad influences to occur for fox after the aluminum hydroxide gel of three times immunity doses were injected. The inoculated foxes could resist challenge of a hundred ID50 virulent strains after the vaccine was injected to foxes for 21 d. Immunity period of the vaccine is 6 months storage period is 10 months at 4-10 degrees C. The field experiments confirmed that the vaccine possessed accuracy, stability and reliability.
Yan
Z
Z
Speciality Institute of CAAS, Jilin.
Yan
X
X
Yan
X
X
Luan
F
F
Wang
C
C
D000818:Animals; D001424:Bacterial Infections / Q000517:prevention & control; D001428:Bacterial Vaccines; D005260:Female; D005589:Foxes; D006194:Gardnerella vaginalis / Q000276:immunology*; D015164:Vaccines, Inactivated; D016585:Vaginosis, Bacterial / Q000517:prevention & control
D001428:Bacterial Vaccines; D015164:Vaccines, Inactivated