Squamous cell carcinoma of the nasal septum with Wegener's granulomatosis treated with cyclophosphamide and corticosteroids.
Well differentiated squamous cell carcinoma of the nasal septum developed in a 55-year old man with Wegener's granulomatosis. It is suggested that the malignancy was induced by immunosuppressive state from an increased and prolonged use of cyclophosphamide and corticosteroids. Although the efficacy of the therapeutic concept using cyclophosphamide and corticosteroids is well established, there have been some few reports that cyclophosphamide could be implicated in the genesis of malignancies. The pathophysiology of Wegener's granulomatosis should be better understood, and effective and less toxic alternative protocol should be established.
Wakisaka
N
N
Department of Otolaryngology, School of Medicine, Kanazawa University, Japan.
Tanaka
S
S
Nagayama
I
I
Furukawa
M
M
D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D001706:Biopsy; D002273:Carcinogens / Q000009:adverse effects*; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000175:diagnosis / Q000532:radiotherapy; D003520:Cyclophosphamide / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D014890:Granulomatosis with Polyangiitis / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009300:Nasal Septum; D009669:Nose Neoplasms / Q000139:chemically induced* / Q000175:diagnosis / Q000532:radiotherapy
D000305:Adrenal Cortex Hormones; D002273:Carcinogens; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide