title: [Basophilic blast crisis in chronic myeloid leukemia].
abstract: Acute basophilic leukaemia is usually characterized by a very rapid clinical course, hyperhistaminemia, resistance to antineoplastic therapy and early death due to complications related to disease. This entity is a rare condition, accounting for less than two percent of all haematopoietic malignancies. Most of the case reports are basophilic blast crisis in patients with a previous lympho or myeloproliferative disorder. A 62-year-old woman who was diagnosed as Philadelphia positive chronic myelogenous leukaemia after four years of evolution developed a basophilic blast crisis, whose characteristics are reported. Accompanying this transformation there was also a cytogenetic change. Despite chemotherapy the patient died of disease progression.
authors.affiliation: Unidad de Hematología, Hospital General Básico, Baza, Granada.
authors.forename: J R
authors.initials: JR
authors.lastname: García Fernández
authors.forename: M A
authors.initials: MA
authors.lastname: montalbán
authors.forename: M L
authors.initials: ML
authors.lastname: Martín
authors.forename: M C
authors.initials: MC
authors.lastname: Ortiz
authors.forename: M A
authors.initials: MA
authors.lastname: Martínez
authors.forename: A
authors.initials: A
authors.lastname: García Marcilla
mesh_terms: D001752:Blast Crisis / Q000150:complications / Q000235:genetics*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007621:Karyotyping; D015471:Leukemia, Basophilic, Acute / Q000150:complications / Q000235:genetics*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000235:genetics*; D008875:Middle Aged
vernacular_title: Crisis blástica basófila de leucemia mieloide crónica.