title: Baroreflex control of muscle sympathetic nerve activity is attenuated in the elderly.
abstract: To determine whether the baroreflex control of sympathetic nerve activity is attenuated in the elderly, muscle sympathetic nerve activity (MSNA) from the tibial nerve was monitored using microneurography, and heart rate and blood pressure were recorded during the depressor (phase II) or pressor (phase IV) period to Valsalva's maneuver in 10 younger subjects and 7 aged subjects. The baroreflex slope for heart rate showed attenuation in the aged subjects during the pressor phase but not during the depressor phase, the baroreflex slope for MSNA was also attenuated in the aged subjects during the pressor and tended to be attenuated during the depressor phases. These data suggest impaired baroreflex function for both heart rate and sympathetic nerve activity in the elderly.
authors.affiliation: Department of Autonomic Neuroscience, Research Institute of Environmental Medicine, Nagoya University, Japan. matsu@riem.nagoya-u.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Matsukawa
authors.forename: Y
authors.initials: Y
authors.lastname: Sugiyama
authors.forename: T
authors.initials: T
authors.lastname: Watanabe
authors.forename: F
authors.initials: F
authors.lastname: Kobayashi
authors.forename: T
authors.initials: T
authors.lastname: Mano
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D017704:Baroreflex / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D004562:Electrocardiography; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007024:Hypotension, Orthostatic / Q000503:physiopathology; D008297:Male; D018482:Muscle, Skeletal / Q000294:innervation*; D013564:Sympathetic Nervous System / Q000502:physiology*; D014636:Valsalva Maneuver / Q000502:physiology*