title: Both nicotine and mecamylamine block dizocilpine-induced explosive jumping behavior in mice: psychiatric implications.
abstract: Dizocilpine (MK-801) administration to an outbred strain of NIH Swiss mice elicits discrete episodes of explosive jumping behavior designated as "popping." This behavior may serve as a useful preclinical paradigm for the screening of potentially novel antipsychotic medications. Both nicotine and mecamylamine, a nicotinic antagonist, dose-dependently blocked dizocilpine-induced popping. The data suggest that nicotine may be of therapeutic benefit in the treatment of schizophrenia and that some of its effects may be mediated by non-nicotinic receptors.
authors.affiliation: Department of Pharmacology, College of Medicine, Howard University, Washington, DC 20059, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Tizabi
authors.forename: J
authors.initials: J
authors.lastname: Mastropaolo
authors.forename: C H
authors.initials: CH
authors.lastname: Park
authors.forename: R L
authors.initials: RL
authors.lastname: Riggs
authors.forename: D
authors.initials: D
authors.lastname: Powell
authors.forename: R B
authors.initials: RB
authors.lastname: Rosse
authors.forename: S I
authors.initials: SI
authors.lastname: Deutsch
mesh_terms: D000818:Animals; D016291:Dizocilpine Maleate / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D008464:Mecamylamine / Q000494:pharmacology*; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009538:Nicotine / Q000494:pharmacology*; D012559:Schizophrenia / Q000188:drug therapy*
chemical_list: D008464:Mecamylamine; D016291:Dizocilpine Maleate; D009538:Nicotine