title: Targeting the shikimate pathway in the malaria parasite Plasmodium falciparum.
abstract: The shikimate pathway presents an attractive target for malaria chemotherapy. Three shikimic acid analogs exhibited different effects on Plasmodium falciparum growth. (6R)-6-Fluoro-shikimate and (6S)-6-fluoro-shikimate inhibited growth (50% inhibitory concentrations, 1.5 x 10(-5) and 2.7 x 10(-4) M, respectively), whereas 2-fluoro-shikimate had no effect. para-Aminobenzoic acid abrogated the inhibition, demonstrating that the shikimate pathway was specifically targeted.
authors.affiliation: Department of Biology, University of Leeds, Leeds LS2 9JT, United Kingdom. g.a.mcconkey@leeds.ac.uk
authors.forename: G A
authors.initials: GA
authors.lastname: McConkey
mesh_terms: D010129:4-Aminobenzoic Acid / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D012765:Shikimic Acid / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: C117868:2-fluoroshikimic acid; C087313:6-fluoroshikimic acid; D000962:Antimalarials; D012765:Shikimic Acid; D010129:4-Aminobenzoic Acid