title: 5-Aminomethylquinoxaline-2,3-diones. Part I: A novel class of AMPA receptor antagonists.
abstract: A series of 5-aminomethylquinoxaline-2,3-diones have been identified as potent and selective AMPA antagonists. Some of these compounds are also active at the glycine-binding site of the NMDA receptors. A number of these novel, water-soluble quinoxaline-2,3-dione derivatives display protective effects in the electroshock-induced convulsion model in mice.
authors.affiliation: Novartis Pharma AG, Basel, Switzerland. yves.auberson@pharma.novartis.com
authors.forename: Y P
authors.initials: YP
authors.lastname: Auberson
authors.forename: S
authors.initials: S
authors.lastname: Bischoff
authors.forename: R
authors.initials: R
authors.lastname: Moretti
authors.forename: M
authors.initials: M
authors.lastname: Schmutz
authors.forename: S J
authors.initials: SJ
authors.lastname: Veenstra
mesh_terms: D000818:Animals; D018691:Excitatory Amino Acid Antagonists / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D011810:Quinoxalines / Q000737:chemistry / Q000494:pharmacology*; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors*; D012640:Seizures / Q000517:prevention & control
chemical_list: D018691:Excitatory Amino Acid Antagonists; D011810:Quinoxalines; D018091:Receptors, AMPA