Serum hepatocyte growth factor level associate with gastric cancer progression.
We have measured serum HGF levels from 80 gastric cancer patients and 51 normal subjects by enzyme-linked immunosorbent assay. The results showed that the mean value of serum HGF level in gastric cancer patients was significantly higher than in normal subjects (0.30 +/- 0.02 vs 0.22 +/- 0.05 ng/ml; p = 0.005). The increase was stage related. Patients with serum HGF < or = 0.30 ng/ml survived longer than those with serum HGF > 0.30 ng/ml (p = 0.02). These data suggest that HGF involve in progression of gastric cancer.
Wu
C W
CW
Department of Surgery, Veterans General Hospital-Taipei, Taiwan, Republic of China. cwwu@isc1.vghtpe.gov.tw
Chi
C W
CW
Su
T L
TL
Liu
T Y
TY
Lui
W Y
WY
P'eng
F K
FK
D000230:Adenocarcinoma / Q000097:blood* / Q000378:metabolism / Q000401:mortality / Q000556:secondary; D000368:Aged; D018450:Disease Progression; D005260:Female; D017228:Hepatocyte Growth Factor / Q000097:blood*; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000097:blood*; D013274:Stomach Neoplasms / Q000097:blood* / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D016019:Survival Analysis
D009363:Neoplasm Proteins; D017228:Hepatocyte Growth Factor