Synthesis and pharmacological evaluation of benzofuran-acetamides as "antineophobic" mitochondrial DBI receptor complex ligands.
A sries of novel benzofuran analogues of N,N-di-n-hexyl-2-phenylindole-3-acetamide (5, FGIN-1-27), a potent and highly specific mitochondrial DBI receptor complex ligand, were synthesized by a modified Fischer method and found in vitro and in vivo to be equally potent and selective as FGIN-1-27.
Liao
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Y
Mayo Foundation for Medical Research and Education, Jacksonville, FL 32224, USA.
Kozikowski
A P
AP
Guidotti
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A
Costa
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E
D000081:Acetamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001667:Binding, Competitive; D002531:Cerebellum / Q000378:metabolism; D015195:Drug Design; D007202:Indicators and Reagents; D007210:Indoleacetic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D007700:Kinetics; D008024:Ligands; D008928:Mitochondria / Q000378:metabolism*; D015394:Molecular Structure; D051381:Rats; D018160:Receptors, Cytoplasmic and Nuclear / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013329:Structure-Activity Relationship
D000081:Acetamides; D001572:Benzofurans; D007202:Indicators and Reagents; D007210:Indoleacetic Acids; D008024:Ligands; D018160:Receptors, Cytoplasmic and Nuclear; C078199:diazepam-binding inhibitor receptor; C081306:N,N-di-n-hexyl-2-(4-fluorophenyl)indole-3-acetamide