Pediatric primary diffuse large cell lymphoma of bone with t(3;22)(q27;q11).
OBJECTIVE
A child with a primary lymphoma of bone (PLB) with a t(3;22)(q27;q11) is described.


METHODS
An 11-year-old boy had a 5-week history of back pain and a destructive lesion of S1 that contained an epidural component. Histologic evaluation of a biopsy confirmed the diagnosis of diffuse large B-cell non-Hodgkin lymphoma. Karyotypic analysis disclosed a t(3;22)(q27;q11), but the amount of tumor tissue was insufficient for molecular studies of the BCL-6 gene.


RESULTS
The patient remains free of disease 4 years after completion of intensive systemic chemotherapy and intrathecal chemotherapy.


CONCLUSIONS
The lymphoma in the patient described in this report is highly unusual because of the coexistence of pediatric PLB and a t(3;22)(q27q11).
Antillon
F
F
Department of Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Behm
F G
FG
Raimondi
S C
SC
Kaste
S C
SC
Sandlund
J T
JT
Pappo
A S
AS
D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology; D002648:Child; D002892:Chromosomes, Human, Pair 22; D002893:Chromosomes, Human, Pair 3; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D014057:Tomography, X-Ray Computed; D014178:Translocation, Genetic