A high-fat diet does not influence the growth of the Dunning R3327-H transplantable prostate adenocarcinoma.
BACKGROUND
The etiology of prostate cancer is currently a mystery. Several epidemiological studies suggest a link between dietary fat and prostate cancer. In vitro and in vivo studies support this evidence. Using the Dunning model of rat prostate cancer we hypothesized that a high-fat diet (20%) would increase the growth of the R3327-H tumor.


METHODS
R3327-H tumors were implanted subcutaneously into male Copenhagen rats which were fed diets with 5 or 20% total fat. Tumors were allowed to grow for 16 weeks; they were then excised and weighed. The initial and final weights of the rats were also recorded.


RESULTS
Statistical analysis revealed the level of dietary fat was a positive predictor of weight gain (p < 0.01). No effect on tumor growth was seen when compared to dietary fat, fiber type, or the interaction of fat and fiber.


CONCLUSIONS
Growth of the R3327-H tumor, when implanted subcutaneously, is not affected by the level of dietary fat.
Schwab
E D
ED
University of Michigan, Ann Arbor 48109, USA.
Normolle
D
D
Pacis
R A
RA
Cho
S S
SS
Pienta
K J
KJ
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004041:Dietary Fats / Q000494:pharmacology*; D008297:Male; D009929:Organ Size; D011467:Prostate / Q000473:pathology; D011471:Prostatic Neoplasms / Q000209:etiology / Q000473:pathology*; D051381:Rats; D015430:Weight Gain
D004041:Dietary Fats