title: Synthesis and immobilization of ceramide analogs on silica particles.
abstract: Ceramides are the major lipid components of the stratum corneum, the major permeability barrier of the skin. Here we report a chemical synthesis of ceramide analogs covalently bonded on the silica particles, that can be used to predict the skin permeability of chemicals via HPLC methods.
authors.affiliation: Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA.
authors.forename: J
authors.initials: J
authors.lastname: Yin
authors.forename: H
authors.initials: H
authors.lastname: Liu
authors.forename: C
authors.initials: C
authors.lastname: Pidgeon
mesh_terms: D002518:Ceramides / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid; D010539:Permeability; D012822:Silicon Dioxide / Q000737:chemistry*; D012867:Skin / Q000378:metabolism
chemical_list: D002518:Ceramides; D012822:Silicon Dioxide