title: X-ray structural characterization of SR 142948, a novel potent synthetic neurotensin receptor antagonist.
abstract: SR 142948 is an original and extremely potent neurotensin receptor antagonist developed in a promising approach to novel antipsychotic drugs. The X-ray structure was elucidated and compared to SR 48692 and levocabastine, providing new informations about the possible recognition process of NT receptor subtypes.
authors.affiliation: Laboratoire de Chimie Moléculaire Structurale, Facultés Universitaires Notre-Dame de la Paix, Namur, Belgium. Luc.Quere@UCB-Group.com
authors.forename: L
authors.initials: L
authors.lastname: Quéré
authors.forename: G
authors.initials: G
authors.lastname: Longfils
authors.forename: R
authors.initials: R
authors.lastname: Boigegrain
authors.forename: B
authors.initials: B
authors.lastname: Labeeuw
authors.forename: D
authors.initials: D
authors.lastname: Gully
authors.forename: F
authors.initials: F
authors.lastname: Durant
mesh_terms: D000818:Animals; D018360:Crystallography, X-Ray; D051379:Mice; D008958:Models, Molecular; D010880:Piperidines / Q000737:chemistry; D011487:Protein Conformation; D011720:Pyrazoles / Q000737:chemistry* / Q000494:pharmacology; D011804:Quinolines / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D018028:Receptors, Neurotensin / Q000037:antagonists & inhibitors*
chemical_list: D010880:Piperidines; D011720:Pyrazoles; D011804:Quinolines; D018028:Receptors, Neurotensin; C114947:SR 142948; C047340:levocabastine