title: Synthesis of some hydroxynaphthazarins and their cardioprotective effects under ischemia-reperfusion in vivo.
abstract: A series of hydroxynaphthazarins has been synthesized. Some of them were found in in vivo experiments to be protectors of myocardium under ischemia-reperfusion and to reduce the infarction zone by 50% without any adverse effect. All compounds exhibit a moderate or small toxicity and are active in low doses.
authors.affiliation: Pacific Institute of Bioorganic Chemistry, Russian Academy of Sciences, Vladivostok, Russia. anufriev@piboc.marine.su
authors.lastname: Anufriev VPh
authors.forename: V L
authors.initials: VL
authors.lastname: Novikov
authors.forename: O B
authors.initials: OB
authors.lastname: Maximov
authors.forename: G B
authors.initials: GB
authors.lastname: Elyakov
authors.forename: D O
authors.initials: DO
authors.lastname: Levitsky
authors.forename: A V
authors.initials: AV
authors.lastname: Lebedev
authors.forename: S M
authors.initials: SM
authors.lastname: Sadretdinov
authors.forename: A V
authors.initials: AV
authors.lastname: Shvilkin
authors.forename: N I
authors.initials: NI
authors.lastname: Afonskaya
authors.lastname: Ruda MYa
authors.forename: N M
authors.initials: NM
authors.lastname: Cherpachenko
mesh_terms: D000818:Animals; D006900:Hydroxylation; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D008956:Models, Chemical; D009203:Myocardial Infarction / Q000517:prevention & control*; D009285:Naphthoquinones / Q000138:chemical synthesis* / Q000494:pharmacology; D005996:Nitroglycerin / Q000494:pharmacology; D011817:Rabbits; D014665:Vasodilator Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D014700:Verapamil / Q000494:pharmacology
chemical_list: D009285:Naphthoquinones; D014665:Vasodilator Agents; C005503:naphthazarin; D014700:Verapamil; D005996:Nitroglycerin