title: Study of standard tablet formulation based on fluidized-bed granulation.
abstract: In this study, acetaminophen, ascorbic acid, and ethenzamide were selected as model drugs for tableting granules. Agitation and fluidized-bed granulation were carried out at three drug contents of 30, 50, and 70%. Compared with agitation granulation, granules made by fluidized-bed granulation showed superior compressibility with wide formulation allowance for drug type and amount. Fluidized-bed granulation resulted in less granule hardness and greater plastic deformability. The granules had considerable compactness and for tablets containing 70% ethenzamide, prolonged disintegration and dissolution times were noted. These are typical features of granules produced by fluidized-bed granulation.
authors.affiliation: Faculty of Pharmacy, Meijo University, Nagoya, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Sunada
authors.forename: M
authors.initials: M
authors.lastname: Hasegawa
authors.forename: T
authors.initials: T
authors.lastname: Makino
authors.forename: H
authors.initials: H
authors.lastname: Sakamoto
authors.forename: K
authors.initials: K
authors.lastname: Fujita
authors.forename: T
authors.initials: T
authors.lastname: Tanino
authors.forename: H
authors.initials: H
authors.lastname: Kokubo
authors.forename: T
authors.initials: T
authors.lastname: Kawaguchi
mesh_terms: D000082:Acetaminophen / Q000737:chemistry; D001205:Ascorbic Acid / Q000737:chemistry; D004339:Drug Compounding; D005079:Excipients; D006245:Hardness Tests; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D011208:Powders; D012457:Salicylamides / Q000737:chemistry; D012995:Solubility; D013607:Tablets / Q000592:standards*
chemical_list: D005079:Excipients; D011208:Powders; D012457:Salicylamides; D013607:Tablets; D000082:Acetaminophen; C018935:ethenzamide; D001205:Ascorbic Acid