title: Apoptosis-gene expression in hematopoietic system: normal and pathological conditions (Review).
abstract: Gene expression involving apoptosis in the hematopoietic system is reviewed. In normal and hematological disorders, Fas-Fas ligand and tumor necrosis factor-alpha-receptor interaction play a major role in enhancing apoptosis. On the other hand, bcl-2 or certain novel proteins (including FADD, RIP, TRADD and sentrin) prevent apoptosis. Apoptosis is involved in myelodysplastic syndrome and pathogenesis of leukemia. Expression of Fas antigen plays a role in negative regulation of hematopoiesis in the bone marrow as does interferon-gamma.
authors.affiliation: Division of Hematology, Department of Internal Medicine, Jichi Medical School, Kawachi, Tochigi 329-04, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Hatake
authors.forename: H
authors.initials: H
authors.lastname: Tomizuka
authors.forename: M
authors.initials: M
authors.lastname: Ikeda
authors.forename: Y
authors.initials: Y
authors.lastname: Terui
authors.forename: Y
authors.initials: Y
authors.lastname: Miura
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D015870:Gene Expression; D006413:Hematopoietic System; D006801:Humans