A matched study to determine whether low-dose aspirin without heparin improves pregnancy rates following frozen embryo transfer and/or affects endometrial sonographic parameters.
OBJECTIVE
The objective of the matched, controlled study was to determine whether low-dose aspirin therapy without heparin improves pregnancy rates following frozen embryo transfer.


METHODS
Thirty-six women who did not achieve a pregnancy following fresh embryo transfer and who had frozen embryos available for another transfer were included. Eighteen women were treated with 81 mg aspirin from day 2 of the cycle through pregnancy testing. If the beta-human chorionic gonadotropin level was positive, aspirin was continued through the pregnancy. Eighteen women were not given aspirin. The mean outcome variables were pregnancy and implantation rates.


RESULTS
The clinical pregnancy rate in the aspirin group was 11.1%, compared with 33.3% for the controls, and implantation rates were 2.9 and 10.9%, respectively.


CONCLUSIONS
No positive effects of low-dose aspirin therapy on pregnancy rates following frozen embryo transfer were observed.
Check
J H
JH
University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Camden, New Jersey, USA.
Dietterich
C
C
Lurie
D
D
Nazari
A
A
Chuong
J
J
D017152:Antibodies, Antiphospholipid; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D010064:Embryo Implantation / Q000187:drug effects*; D004624:Embryo Transfer / Q000379:methods*; D004717:Endometrium / Q000000981:diagnostic imaging*; D005260:Female; D006493:Heparin; D006801:Humans; D008597:Menstrual Cycle; D011247:Pregnancy; D018873:Pregnancy Rate; D014463:Ultrasonography
D017152:Antibodies, Antiphospholipid; D018997:Chorionic Gonadotropin, beta Subunit, Human; D006493:Heparin; D001241:Aspirin