title: Design and synthesis of isoxazole and isoxazoline linkage for replacement of nucleotide phosphodiester.
abstract: Synthetic routes for oligonucleotides which have isoxazoline or isoxazole linkage have been developed, and di- and tri-nucleotides with thymine bases have been prepared.
authors.affiliation: Department of Chemistry, Pohang University of Science and Technology, Korea.
authors.forename: S J
authors.initials: SJ
authors.lastname: Kim
authors.forename: J Y
authors.initials: JY
authors.lastname: Lee
authors.forename: B H
authors.initials: BH
authors.lastname: Kim
mesh_terms: D015195:Drug Design; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D013936:Thymidine / Q000737:chemistry
chemical_list: D007555:Isoxazoles; D009841:Oligonucleotides; D013936:Thymidine