Serine derived NK1 antagonists. 1: The effect of modifications to the serine substituents.
A series of novel serine derived NK1 antagonists is described. The effect of variations in the N-benzyl, O-benzyl and serine groups are used to define the elements which are necessary for binding.
Elliott
J M
JM
Merck Sharp and Dohme Research Laboratories, Neuroscience Research Center, Harlow, Essex, U.K. jason_elliott@merck.com
Cascieri
M A
MA
Chicchi
G
G
Davies
S
S
Kelleher
F J
FJ
Kurtz
M
M
Ladduwahetty
T
T
Lewis
R T
RT
MacLeod
A M
AM
Merchant
K J
KJ
Sadowski
S
S
Stevenson
G I
GI
D064729:Neurokinin-1 Receptor Antagonists; D010880:Piperidines / Q000737:chemistry / Q000494:pharmacology*; D012694:Serine / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D064729:Neurokinin-1 Receptor Antagonists; D010880:Piperidines; D012694:Serine