title: [Sexually transmitted infection as a cause of anal cancer].
abstract: Interviews were carried out with 423 women and 93 men with invasive or in situ anal cancer in Denmark and Sweden in a search for clues to the aetiology of this neoplasm. Patients with rectal adenocarcinoma (n = 534) and persons drawn from the background population (n = 554) served as controls. Multivariate logistic regression analyses confirmed previous observations of a strong association between either male homosexual experience or a history of anogenital warts and the risk for anal cancer. Moreover, hitherto unknown, but strong and consistent associations were observed between measures of high heterosexual activity and the risk for anal cancer among both sexes. Polymerase chain reaction analysis revealed human papilloma-virus DNA in the majority (88%) of anal cancer specimens but in none of 20 examined rectal adenocarcinomas. It is concluded that most anal cancers appear to be caused by sexually transmitted types of human papillomaviruses and, consequently, that anal cancer is a potentially preventable neoplasm.
authors.affiliation: Afdeling for epidemiologisk forskning, Statens Serum Institut, København. mfr@ssi.dk
authors.forename: M
authors.initials: M
authors.lastname: Frisch
authors.forename: B
authors.initials: B
authors.lastname: Glimelius
authors.forename: A I
authors.initials: AI
authors.lastname: van den Brule
authors.forename: J
authors.initials: J
authors.lastname: Wohlfahrt
authors.forename: C J
authors.initials: CJ
authors.lastname: Meijer
authors.forename: J M
authors.initials: JM
authors.lastname: Walboomers
authors.forename: S
authors.initials: S
authors.lastname: Goldman
authors.forename: C
authors.initials: C
authors.lastname: Svensson
authors.forename: H O
authors.initials: HO
authors.lastname: Adami
authors.forename: M
authors.initials: M
authors.lastname: Melbye
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology / Q000821:virology*; D000328:Adult; D000368:Aged; D001005:Anus Neoplasms / Q000209:etiology / Q000821:virology*; D016022:Case-Control Studies; D003718:Denmark; D005260:Female; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000150:complications / Q000635:transmission*; D016133:Polymerase Chain Reaction; D012004:Rectal Neoplasms / Q000209:etiology / Q000821:virology*; D012044:Regression Analysis; D019529:Sexuality; D015229:Sexually Transmitted Diseases, Viral / Q000150:complications*; D011795:Surveys and Questionnaires
vernacular_title: Seksuelt overført infektion som årsag til analcancer.