A new antitumor agent: methyl sulfonium perchlorate of echinomycin.
Newly modified-echinomycin such as S-methylated sulfonium perchlorate of echinomycin (1), monosulfoxide (2), disulfoxid (3) and sulfone (4) have been prepared and evaluated for in vitro biological activities of cytotoxicity against P388, B16 and SNU-16 as well as in vivo antitumor activity against murine leukemia P388 and melanoma B16.
Park
Y S
YS
Department of Chemistry, Korea Advanced Institute of Science and Technology, Taejon, Korea.
Kim
Y H
YH
Kim
S K
SK
Choi
S J
SJ
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D015195:Drug Design; D004448:Echinomycin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000627:therapeutic use / Q000633:toxicity; D007941:Leukemia P388 / Q000188:drug therapy*; D008546:Melanoma, Experimental / Q000188:drug therapy*; D051379:Mice; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013450:Sulfones / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D013454:Sulfoxides / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D014407:Tumor Cells, Cultured
D000903:Antibiotics, Antineoplastic; C116620:S-methylechinomycin; D013450:Sulfones; D013454:Sulfoxides; D004448:Echinomycin