[Brain lipid composition of the rat with experimental morphine dependence].
The brain phospholipid content was studied in rats with morphine physical dependence. It was found that level of total lipids, total phospholipids and cholesterol was diminished. The significant decrease of absolute amounts of phosphotidyl serine, phosphotidyl inositol, sphingomyelin and phosphatidyl choline was shown. At the same time the percent relation of individual phospholipids did not change. As the exclusion, the quantity of phosphatidyl ethanolamine plasmalogen lowered in rats with morphine dependence. The percent content of fatty acids 16:0, 18:1 omega 9, 20:1 omega 11, 20:4 omega 6 and 22:5 omega 3 was found to be reduced. At the same time the percent amount of i18:0 and 20:0 was shown to increase. As a result the unsaturation index dramatically diminished. It was also shown that under morphine physical dependence the acyl residues of phosphatidyl choline and phosphatidyl ethanolamine changed. It was concluded that lipids play significant role in the development of morphine physical dependence.
Hula
N M
NM
O.V. Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine.
Marhitych
V M
VM
Hovseieva
N M
NM
Klimashevs'kyĭ
V M
VM
Zhukov
O D
OD
Synyts'kyĭ
V M
VM
D000818:Animals; D001921:Brain / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism; D008297:Male; D009021:Morphine Dependence / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats
D005227:Fatty Acids; D010743:Phospholipids
Zminy lipdnoho skladu mozku tvaryn z eksperymental'noiu morfinnoiu zalezhnistiu.