Chemo-enzymatic transformations in sensitive systems: lipase mediated hydrolysis of vancomycin esters.
Recently, an interest in the development of new vancomycin derivatives has been demonstrated. Here, the feasibility of using lipases, particularly those from Pseudomonas sp., for the hydrolysis of vancomycin alkyl esters is demonstrated. Benzyl ester derivatives were more easily cleavable than methyl ester derivatives, resulting in good yields of vancomycin acids without degradation.
Adamczyk
M
M
Department of Chemistry, Abbott Diagnostics Division, Abbott Laboratories, Abbott Park, IL 60064-3500, USA.
Grote
J
J
Rege
S
S
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D001593:Benzyl Compounds / Q000138:chemical synthesis / Q000737:chemistry; D004952:Esters; D006868:Hydrolysis; D007202:Indicators and Reagents; D008049:Lipase; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D011549:Pseudomonas / Q000201:enzymology; D013329:Structure-Activity Relationship; D014640:Vancomycin / Q000031:analogs & derivatives* / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D001593:Benzyl Compounds; D004952:Esters; D007202:Indicators and Reagents; D014640:Vancomycin; D008049:Lipase