Synthesis and antioxidant activity of novel amphipathic derivatives of tea polyphenol.
Hydrophobic derivatives of a tea polyphenol have been synthesized. 6, 8-Bis(octylthiomethyl)-epigallocatechin 3-O-gallate, 6, 8-bis(octylthiomethyl)-4 beta-(2-hydroxyethylthio)epigallocatechin 3-O-gallate and epigallocatechin 3-O-[4-O-(N-octadecylcarbamoyl)gallate] showed strong inhibition activity against lipid peroxidation of liposome caused by both lipid-soluble and water-soluble radical generators.
Tanaka
T
T
School of Pharmaceutical Sciences, Nagasaki University, Japan.
Kusano
R
R
Kouno
I
I
D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology; D002392:Catechin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008051:Lipid Bilayers; D015227:Lipid Peroxidation / Q000187:drug effects; D013662:Tea / Q000737:chemistry*
D000975:Antioxidants; D008051:Lipid Bilayers; D013662:Tea; D002392:Catechin; C045651:epigallocatechin gallate