Reactions of 7- and 9-aminoadenines with 2,4-pentanedione. Formation of new ring systems, pyridazino[6,1-f]purine and pyridazino[1,6-e]purine.
Reactions of 7-aminoadenines with 2,4-pentanedione yielded pyridazino[6,1-f]purines and 5-pyrazolylpyrimidines. The structure of the latter was identified by X-ray analysis. Reaction of 9-amino-N6-methyladenine with 2,4-pentanedione gave pyridazino[1,6-e]purine and Schiff base products. Possible reaction mechanisms are discussed.
Kaiya
T
T
Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
Saga
T
T
Yamagata
Y
Y
Kohda
K
K
D018360:Crystallography, X-Ray; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D010422:Pentanones / Q000737:chemistry*; D011687:Purines / Q000138:chemical synthesis* / Q000737:chemistry
D007202:Indicators and Reagents; D010422:Pentanones; D011687:Purines; C008790:acetylacetone