Role of superoxide dismutase in ischemic brain injury: a study using SOD-1 transgenic mice.
1. Nitric oxide radicals (NO) play an important role in the pathophysiology of focal cerebral ischemia. 2. Vascular NO can reduce ischemic brain injury by increasing CBF, whereas neuronal NO may mediate neurotoxicity following brain ischemia, mainly by its reaction with superoxide to generate peroxynitrite. 3. These findings could contribute to a strategy for the treatment of cerebral ischemia.
Kinouchi
H
H
Department of Neurosurgery, Tohoku University School of Medicine, Sendai, Japan.
Kamii
H
H
Mikawa
S
S
Epstein
C J
CJ
Yoshimoto
T
T
Chan
P H
PH
D000818:Animals; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D002545:Brain Ischemia / Q000503:physiopathology* / Q000517:prevention & control / Q000628:therapy*; D002544:Cerebral Infarction / Q000473:pathology / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D009566:Nitrates / Q000378:metabolism; D009569:Nitric Oxide / Q000502:physiology; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism*; D013481:Superoxides / Q000378:metabolism
D009566:Nitrates; D013481:Superoxides; C039642:peroxynitric acid; D009569:Nitric Oxide; D013482:Superoxide Dismutase