Synthesis of aryl semicarbazone of 4-aminoacetophenone and their anti-HIV activity.
The thioureido derivative of 4-aminoacetophenone aryl semicarbazone have been prepared. These derivatives have been characterised on the basis of different physicochemical evidences. The anti-HIV-1 (HTLV-IIIB) and -HIV-2 (ROD) activity and cytotoxicity of the compounds were tested. The compound VII and VIII showed maximum protection among the series.
Mishra
V
V
Department of Applied Chemistry, Institute of Technology, Banaras Hindu University, Varanasi, India.
Pandeya
S N
SN
DeClercq
E
E
Pannecouque
C
C
Witvrouw
M
M
D000098:Acetophenones / Q000138:chemical synthesis* / Q000494:pharmacology*; D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002461:Cell Line, Transformed; D015497:HIV-1 / Q000187:drug effects; D015498:HIV-2 / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008826:Microbial Sensitivity Tests; D012664:Semicarbazones / Q000138:chemical synthesis* / Q000494:pharmacology*
D000098:Acetophenones; D019380:Anti-HIV Agents; D012664:Semicarbazones; C032065:4-aminoacetophenone