New phthalimide derivatives with potent analgesic activity: II.
Seven new phthalimide derivatives (9a-g) with 1,2,4-oxadiazol-5-yl methyl group attached to nitrogen have been synthesized from N-phthaloylglycine 6 and arylamidoximes 7a-g. All of these showed potent analgesic effect with acetic acid induced "writhing" test in mice. One of the better compounds (ID50 = 2.2 mg/Kg i.p.) has been found to be 9a which also demonstrates analgesic activity against inflammatory pain.
Antunes
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R
Departamento de Química Fundamental, Universidade Federal de Pernambuco, Recife, PE, Brazil.
Batista
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H
Srivastava
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RM
Thomas
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G
Araujo
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CC
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D010797:Phthalimides / Q000138:chemical synthesis* / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010797:Phthalimides