Reactions of 1-methylbenzimidazole derivatives with m-chloroperoxybenzoic acid.
Oxidation of seven 1-methylbenzimidazole (MBI) derivatives (with pKa's ranging from 1.6 to 6.0) was carried out with m-chloroperoxybenzoic acid and structures of the products formed were identified. (Condensed benzene moiety-hydroxylated)-2-(m-chlorobenzyloxy)-MBIs and 2-oxo-MBIs were obtained from MBIs with pKa's of more than 5.6 and about 3.3, respectively.
Kaiya
T
T
Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
Aoyama
S
S
Kohda
K
K
D001562:Benzimidazoles / Q000378:metabolism*; D002723:Chlorobenzoates / Q000378:metabolism*; D007202:Indicators and Reagents / Q000378:metabolism*; D008745:Methylation; D008956:Models, Chemical
D001562:Benzimidazoles; D002723:Chlorobenzoates; D007202:Indicators and Reagents; C000433:3-chloroperbenzoic acid