title: Ultra-wideband electromagnetic pulses and morphine-induced changes in nociception and activity in mice.
abstract: Mice were exposed to ultra-wideband (UWB) electromagnetic pulses averaging 99-105 kV/m peak amplitude, 0.97-1.03 ns duration, and 155-174 ps rise time, after intraperitoneal administration of saline or morphine sulfate. They were then tested for thermal nociception on a 50 degrees C surface and for spontaneous locomotor activity and its time profile over 5 min. Analysis of results showed no effect of UWB exposure on nociception and activity measures in CF-1 mice after 15-, 30-, or 45-min exposure to pulses at 600/s or after 30-min exposure to UWB pulses at 60/s. Similarly, no effect was seen in C57BL/6 mice after 30-min exposure to pulses at 60/s or 600/s. Although trends in morphine-modified measures seen with UWB pulse repetition frequency could be expected because of increased levels of low-frequency energy, no significant change was seen in normal or morphine-modified nociception or activity after UWB exposure. This indicated lack of effect of the UWB pulses used in these experiments on nervous system components, including endogenous opioids, involved in these behaviors.
authors.affiliation: McKesson BioServices and Microwave Bioeffects Branch, US Army Medical Research Detachment, Brooks AFB, TX 78235-5460, USA. ronald.seaman@aloer.brooks.af.mil
authors.forename: R L
authors.initials: RL
authors.lastname: Seaman
authors.forename: M L
authors.initials: ML
authors.lastname: Belt
authors.forename: J M
authors.initials: JM
authors.lastname: Doyle
authors.forename: S P
authors.initials: SP
authors.lastname: Mathur
mesh_terms: D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D004558:Electric Stimulation; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009020:Morphine / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D009619:Nociceptors / Q000187:drug effects*; D010146:Pain / Q000503:physiopathology*; D010147:Pain Measurement / Q000187:drug effects
chemical_list: D000701:Analgesics, Opioid; D009020:Morphine