title: Rational design of a new series of mixed anti-HIV pronucleotides.
abstract: MonoSATE aryl phosphotriesters of AZT are able to deliver intracellularly the corresponding 5'-mononucleotide. This process requires activation by an esterase followed by a phosphodiesterase. This finding opens the way to the design of new pronucleotide series.
authors.affiliation: Laboratoire de Chimie Bioorganique, U.M.R. C.N.R.S. 5625, Université Montpellier II, France.
authors.forename: N
authors.initials: N
authors.lastname: Schlienger
authors.forename: T
authors.initials: T
authors.lastname: Beltran
authors.forename: C
authors.initials: C
authors.lastname: Périgaud
authors.forename: I
authors.initials: I
authors.lastname: Lefebvre
authors.forename: A
authors.initials: A
authors.lastname: Pompon
authors.forename: A M
authors.initials: AM
authors.lastname: Aubertin
authors.forename: G
authors.initials: G
authors.lastname: Gosselin
authors.forename: J L
authors.initials: JL
authors.lastname: Imbach
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis*; D015195:Drug Design; D006801:Humans; D009711:Nucleotides / Q000138:chemical synthesis*; D011355:Prodrugs / Q000138:chemical synthesis*; D015215:Zidovudine / Q000031:analogs & derivatives*
chemical_list: D019380:Anti-HIV Agents; D009711:Nucleotides; D011355:Prodrugs; D015215:Zidovudine