title: Experience gained from operation of 103 adrenal incidentalomas.
abstract: BACKGROUND
  Adrenal incidentaloma poses a perplexing problem for physicians. The challenge is to identify the rare functioning or malignant adrenal tumor that should be removed.
  
  
  METHODS
  From 1970 until December 1996, we managed 579 patients with adrenal hyperplasia or neoplasm. Of these, 110 were followed without any operation and 469 were operated on. The histology from the operated patients revealed 145 pheochromocytomas, 72 Cushing's syndrome, 98 aldosteronomas, 21 virilizing tumors, 3 feminizing tumors, 98 non-functioning adrenalomas, 17 metastases, 7 cysts, and 15 miscellaneous tumors.
  
  
  RESULTS
  Among the 98 non-functioning adrenal tumors, 79 were incidentalomas. Histological examination of 103 operated incidentalomas found 55 adenomas (5 functioning=aldosteronomas), 12 benign pheochromocytomas, 3 malignant or suspicious pheochromocytomas, 8 cystic lymphangiomas, 4 metastases, 4 angiomas, 3 ganglioneuromas, 4 myelolipomas, 1 hyperplasia, 2 hematomas, 2 cysts, and 5 adreno-cortical carcinomas. Among the non-operated incidentalomas, the most frequent findings were adenomas, metastases, hematomas, cysts and pseudotumoral hyperplasia; three disappeared spontaneously. No patients died of unrecognized adrenocortical carcinoma.
  
  
  CONCLUSIONS
  Our experience confirms that in case of incidentaloma, the first concern is a nonfunctional pheochromocytoma (15%), and the less common occurrence is adreno-cortical carcinoma (2%). We recommend a restrictive surgical approach in the setting of adrenal incidentalomas.
authors.affiliation: Clinique Chirurgicale Adulte Est, Service de Chirurgie Générale et Endocrinienne, Hôpital Huriez, CHU de Lille, France.
authors.forename: C
authors.initials: C
authors.lastname: Proye
authors.forename: M
authors.initials: M
authors.lastname: Jafari Manjili
authors.forename: F
authors.initials: F
authors.lastname: Combemale
authors.forename: F
authors.initials: F
authors.lastname: Pattou
authors.forename: O
authors.initials: O
authors.lastname: Ernst
authors.forename: B
authors.initials: B
authors.lastname: Carnaille
authors.forename: J L
authors.initials: JL
authors.lastname: Wemeau
mesh_terms: D000236:Adenoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D000306:Adrenal Cortex Neoplasms / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D000310:Adrenal Gland Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery*; D000315:Adrenalectomy / Q000379:methods / Q000401:mortality; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D010535:Laparoscopy; D008297:Male; D010673:Pheochromocytoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D015996:Survival Rate