Synthesis of bisindolylmaleimides using a palladium catalyzed cross-coupling reaction.
Bisindolylmaleimides are known to be potent and selective PKC inhibitors. A new synthesis of this class of compound is reported. The key step is a Suzuki cross-coupling reaction using a readily available indolylmaleimide triflate intermediate.
Neel
D A
DA
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA.
Jirousek
M R
MR
McDonald
J H
JH
D002384:Catalysis; D003432:Cross-Linking Reagents / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D008301:Maleimides / Q000138:chemical synthesis* / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D011493:Protein Kinase C / Q000037:antagonists & inhibitors
D003432:Cross-Linking Reagents; D004791:Enzyme Inhibitors; D007211:Indoles; D008301:Maleimides; D010165:Palladium; D011493:Protein Kinase C; C088060:bisindolylmaleimide