title: No impaired cognitive function in treated patients with mild-moderate hypertension compared to normotensive controls.
abstract: Hypertension is a predictor for impaired cognitive function and dementia in several prospective studies. It is currently under debate whether treatment of hypertension, and thus blood pressure lowering, is another risk factor for cognitive decline. We recruited a sample of 123 treated hypertensive patients and 76 normotensive controls, from a population-based study in primary health care, for screening of blood pressure, metabolic variables and cognitive function, as measured by the Mini-Mental State Examination (MMSE). Treated hypertensives had higher blood pressure but did not differ in cognitive function from the normotensives. Neither educational level nor metabolic variables confounded the findings. In conclusion, treated hypertensives did not differ in cognitive function from normotensive controls. This does not support the notion that pharmacological blood pressure reduction impairs cognitive function.
authors.affiliation: Department of Community Health Sciences, University of Lund, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Nilsson
authors.forename: G
authors.initials: G
authors.lastname: Gullberg
authors.forename: R
authors.initials: R
authors.lastname: Ekesbo
authors.forename: H
authors.initials: H
authors.lastname: Von Schenck
authors.forename: L
authors.initials: L
authors.lastname: Gustafson
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001794:Blood Pressure; D003071:Cognition / Q000187:drug effects*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology*; D008297:Male; D008875:Middle Aged
chemical_list: D000959:Antihypertensive Agents