title: Analysis of left ventricular wall motion based on volumetric deformable models and MRI-SPAMM.
abstract: We present a new approach for the analysis of the left ventricular shape and motion based on the development of a new class of volumetric deformable models. We estimate the deformation and complex motion of the left ventricle (LV) in terms of a few parameters that are functions and whose values vary locally across the LV. These parameters capture the radial and longitudinal contraction, the axial twisting, and the long-axis deformation. Using Lagrangian dynamics and finite-element theory, we convert these volumetric primitives into dynamic models that deform due to forces exerted by the datapoints. We present experiments where we used magnetic tagging (MRI-SPAMM) to acquire datapoints from the LV during systole. By applying our method to MRI-SPAMM datapoints, we were able to characterize the 3-D shape and motion of the LV both locally and globally, in a clinically useful way. In addition, based on the model parameters we were able to extract quantitative differences between normal and abnormal hearts and visualize them in a way that is useful to physicians.
authors.affiliation: Department of Computer and Information Science, University of Pennsylvania, Philadelphia 19104-6389, USA. jinah@graphics.cis.upenn.edu
authors.forename: J
authors.initials: J
authors.lastname: Park
authors.forename: D
authors.initials: D
authors.lastname: Metaxas
authors.forename: L
authors.initials: L
authors.lastname: Axel
mesh_terms: D019412:Anatomy, Cross-Sectional; D002306:Cardiac Volume / Q000502:physiology*; D002311:Cardiomyopathy, Dilated / Q000473:pathology / Q000503:physiopathology; D003198:Computer Simulation; D006352:Heart Ventricles / Q000033:anatomy & histology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D015203:Reproducibility of Results; D013599:Systole; D016276:Ventricular Function; D016277:Ventricular Function, Left