Right hemisphere language in a neurologically normal dextral: a fMRI study.
Dextrals with right cerebral hemisphere dominance for language are rare. Eight neurologically intact dextrals underwent BOLD-fMRI while being presented auditory and visual words. Fortuitously, in one subject, right hemisphere activations with visually presented words were seen in the inferior frontal, premotor regions together with predominantly left cerebellar activation. These were a mirror image of activations obtained from the seven other dextrals. Also mirrored was temporal activation from auditory words which extended more posteriorly on the right side than the left. These results showing mirror organization of language were replicated in another scanning session and also by using a second word task. Although rare, mirrored organization of language can occur in normal dextrals without penalizing language function.
Chee
M W
MW
MGH-NMR Center, Massachusetts General Hospital, Charlestown 02129, USA.
Buckner
R L
RL
Savoy
R L
RL
D000161:Acoustic Stimulation; D000328:Adult; D001303:Auditory Cortex / Q000502:physiology*; D001307:Auditory Perception / Q000502:physiology; D002531:Cerebellum / Q000502:physiology; D004292:Dominance, Cerebral / Q000502:physiology*; D005625:Frontal Lobe / Q000502:physiology; D006801:Humans; D007802:Language; D008279:Magnetic Resonance Imaging; D008297:Male; D009044:Motor Cortex / Q000502:physiology; D010775:Photic Stimulation; D014706:Verbal Learning / Q000502:physiology; D014793:Visual Cortex / Q000502:physiology