Synthesis and in vitro cytotoxicity of 3- or 4-dialkylaminomethyl-1-azaanthraquinones.
Six 3-dialkylaminomethyl-1-azaanthraquinones and five 4-dialkylaminomethyl-1-azaanthraquinones were synthesized and evaluated in vitro cytotoxicity against four human cancer cell lines. The compounds retained much of their cytotoxic activity against the multi-drug-resistant cell line (KB-V-1) as shown by resistance index.
Lee
H
H
College of Pharmacy, Chungbuk National University, Cheongju, Korea.
Choi
J Y
JY
Lee
S I
SI
Hong
S S
SS
Cho
J
J
Kim
Y H
YH
D000880:Anthraquinones / Q000138:chemical synthesis / Q000627:therapeutic use* / Q000633:toxicity; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001372:Aza Compounds / Q000138:chemical synthesis / Q000627:therapeutic use* / Q000633:toxicity; D004341:Drug Evaluation; D006801:Humans; D014407:Tumor Cells, Cultured
D000880:Anthraquinones; D000970:Antineoplastic Agents; D001372:Aza Compounds