title: Synthesis and structure-activity relationships of 2-pyridones: II. 8-(Fluoro-substituted pyrrolidinyl)-2-pyridones as antibacterial agents.
abstract: The 8-position side chain of 2-pyridones is believed to be involved in the binding with bacterial DNA gyrase to form the ternary complex, making them very important for the activity of 2-pyridones. A series of 2-pyridones having fluoro-substituted amines at the 8-position has been synthesized and their antibacterial activities and parmacokinetic properties are reported.
authors.affiliation: Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, Illinois 60064-3500, USA.
authors.forename: Q
authors.initials: Q
authors.lastname: Li
authors.forename: W
authors.initials: W
authors.lastname: Wang
authors.forename: K B
authors.initials: KB
authors.lastname: Berst
authors.forename: A
authors.initials: A
authors.lastname: Claiborne
authors.forename: L
authors.initials: L
authors.lastname: Hasvold
authors.forename: K
authors.initials: K
authors.lastname: Raye
authors.forename: M
authors.initials: M
authors.lastname: Tufano
authors.forename: A
authors.initials: A
authors.lastname: Nilius
authors.forename: L L
authors.initials: LL
authors.lastname: Shen
authors.forename: R
authors.initials: R
authors.lastname: Flamm
authors.forename: J
authors.initials: J
authors.lastname: Alder
authors.forename: K
authors.initials: K
authors.lastname: Marsh
authors.forename: D
authors.initials: D
authors.lastname: Crowell
authors.forename: D T
authors.initials: DT
authors.lastname: Chu
authors.forename: J J
authors.initials: JJ
authors.lastname: Plattner
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D001682:Biological Availability; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006207:Half-Life; D008826:Microbial Sensitivity Tests; D011728:Pyridones / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D011728:Pyridones