title: The PIR-International Protein Sequence Database.
abstract: The Protein Information Resource (PIR; http://www-nbrf.georgetown. edu/pir/) supports research on molecular evolution, functional genomics, and computational biology by maintaining a comprehensive, non-redundant, well-organized and freely available protein sequence database. Since 1988 the database has been maintained collaboratively by PIR-International, an international association of data collection centers cooperating to develop this resource during a period of explosive growth in new sequence data and new computer technologies. The PIR Protein Sequence Database entries are classified into superfamilies, families and homology domains, for which sequence alignments are available. Full-scale family classification supports comparative genomics research, aids sequence annotation, assists database organization and improves database integrity. The PIR WWW server supports direct on-line sequence similarity searches, information retrieval, and knowledge discovery by providing the Protein Sequence Database and other supplementary databases. Sequence entries are extensively cross-referenced and hypertext-linked to major nucleic acid, literature, genome, structure, sequence alignment and family databases. The weekly release of the Protein Sequence Database can be accessed through the PIR Web site. The quarterly release of the database is freely available from our anonymous FTP server and is also available on CD-ROM with the accompanying ATLAS database search program.
authors.affiliation: Protein Information Resource, National Biomedical Research Foundation, Washington, DC 20007, USA, USA.
authors.forename: W C
authors.initials: WC
authors.lastname: Barker
authors.forename: J S
authors.initials: JS
authors.lastname: Garavelli
authors.forename: P B
authors.initials: PB
authors.lastname: McGarvey
authors.forename: C R
authors.initials: CR
authors.lastname: Marzec
authors.forename: B C
authors.initials: BC
authors.lastname: Orcutt
authors.forename: G Y
authors.initials: GY
authors.lastname: Srinivasarao
authors.forename: L S
authors.initials: LS
authors.lastname: Yeh
authors.forename: R S
authors.initials: RS
authors.lastname: Ledley
authors.forename: H W
authors.initials: HW
authors.lastname: Mewes
authors.forename: F
authors.initials: F
authors.lastname: Pfeiffer
authors.forename: A
authors.initials: A
authors.lastname: Tsugita
authors.forename: C
authors.initials: C
authors.lastname: Wu
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D019295:Computational Biology; D016208:Databases, Factual; D016678:Genome; D006801:Humans; D016247:Information Storage and Retrieval; D007391:International Cooperation; D011506:Proteins / Q000737:chemistry* / Q000235:genetics; D017386:Sequence Homology, Amino Acid
chemical_list: D011506:Proteins