Novel alternative splicing in the 5' exon of the neurotrophin-3 gene.
The neurotrophin-3 (NT-3) gene has previously been reported to consist of three exons including two 5' short untranslated exons and a 3' long exon encoding the entire protein, and to give rise to two classes of transcripts by alternative splicing of the 5' exons to the 3' coding exon. In the present study, we demonstrated the presence of at least four new classes of transcripts of the NT-3 gene, in addition to the two known transcripts. The present finding proposes the further complexity of the regulational mechanism for NT-3 expression.
Sekimoto
M
M
Laboratory of Health Science, School of Pharmaceutical Sciences, University of Shizuoka, Japan.
Fukamachi
K
K
Nemoto
F
F
Miyata
S
S
Degawa
M
M
Senba
E
E
Ueyama
T
T
Nemoto
K
K
D017398:Alternative Splicing / Q000502:physiology*; D000818:Animals; D003001:Cloning, Molecular; D017931:DNA Primers; D005091:Exons / Q000502:physiology*; D015870:Gene Expression / Q000502:physiology; D008297:Male; D008969:Molecular Sequence Data; D009414:Nerve Growth Factors / Q000235:genetics*; D018696:Neuroprotective Agents / Q000378:metabolism; D020933:Neurotrophin 3; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D011921:Rats, Inbred WKY; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017386:Sequence Homology, Amino Acid; D014158:Transcription, Genetic / Q000502:physiology
D017931:DNA Primers; D009414:Nerve Growth Factors; D018696:Neuroprotective Agents; D020933:Neurotrophin 3; D012333:RNA, Messenger; C073922:neurotrophin 4