title: Use of sensitized luminescence of lanthanides in analysis of drugs.
abstract: The sensitization of the Tb(III) and Eu(III) ions luminescence by drugs, the pyrocatechol, naphthyridine and heterocyclic aromatic acid derivatives, were studied. It was shown that a result of intramolecular energy transfer from the ligand molecule to the lanthanide ion increases the luminescence intensity of the latter by 10(8)-10(10) times. The luminescence properties of the complexes in solutions were investigated. The highly sensitive methods for luminescence determination of dopegyt, levodopum, dophaminum, nevigramon, furosemidum and cinchophenum were developed. The detection limits of the drugs are 0.0005, 0.02, 0.5, 0.01, 0.05 and 0.1, respectively.
authors.affiliation: A.V. Bogatsky Physico-Chemical Institute of the National Academy of Sciences of Ukraine, Odessa.
authors.forename: S V
authors.initials: SV
authors.lastname: Beltyukova
authors.forename: E I
authors.initials: EI
authors.lastname: Tselik
authors.forename: A V
authors.initials: AV
authors.lastname: Egorova
mesh_terms: D000147:Acids, Heterocyclic / Q000032:analysis*; D002396:Catechols / Q000032:analysis*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D005063:Europium / Q000032:analysis / Q000737:chemistry; D006841:Hydrocarbons, Aromatic / Q000032:analysis*; D007477:Ions; D008024:Ligands; D008163:Luminescent Measurements; D008674:Metals, Rare Earth / Q000032:analysis* / Q000378:metabolism; D015394:Molecular Structure; D009930:Organic Chemicals / Q000032:analysis* / Q000378:metabolism; D013725:Terbium / Q000032:analysis / Q000737:chemistry
chemical_list: D000147:Acids, Heterocyclic; D002396:Catechols; D006841:Hydrocarbons, Aromatic; D007477:Ions; D008024:Ligands; D008674:Metals, Rare Earth; D009930:Organic Chemicals; D013725:Terbium; D005063:Europium; C034221:catechol