A longitudinal study of semen quality in pesticide spraying Danish farmers. The ASCLEPIOS Study Group.
It was hypothesized that occupational exposure to pesticides during a spraying season causes changes in semen quality that might be detected in a longitudinal study. We analyzed the within-person changes in semen quality and reproductive hormones across a spraying season in groups of farmers using and not using pesticides. A total of 248 men collected two semen samples (participation rate: 32%). The median sperm concentration declined significantly from the first to the second sample in both groups, but there was no statistical difference in the decline between the two groups, unadjusted or adjusted. Only minor changes were found in sperm morphology, vitality, motility, sperm chromatin denaturation (SCSA), and reproductive hormones, and the differences in changes between the two groups were nonsignificant, or, in the opposite direction to the expected. There was no relation between the changes in sperm parameters in relation to pesticide exposure variables. In conclusion, use of pesticides by Danish farmers is not a likely cause of short-term effects on semen quality and reproductive hormones.
Larsen
S B
SB
Department of Occupational Medicine, Aarhus University Hospital, Denmark.
Giwercman
A
A
Spanò
M
M
Bonde
J P
JP
D000293:Adolescent; D000328:Adult; D000382:Agricultural Workers' Diseases / Q000139:chemically induced*; D003718:Denmark; D005434:Flow Cytometry; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D010575:Pesticides / Q000633:toxicity*; D012661:Semen / Q000187:drug effects*; D012728:Sex Chromatin / Q000187:drug effects
D012739:Gonadal Steroid Hormones; D010575:Pesticides