title: Rapid gastric emptying of a liquid meal in long-term Type 2 diabetes mellitus.
abstract: Both delayed and accelerated gastric emptying rate (GER) have been reported in patients with diabetes mellitus. Delayed GER has been attributed to autonomic neuropathy in established diabetes but rapid GER was demonstrated in early Type 2 diabetes. The aim of the study was to investigate rapid gastric emptying in a group of people with long-duration Type 2 diabetes. GER of a radiolabelled liquid meal was studied scintigraphically in 20 Type 2 patients with a mean (+/-SEM) duration of diabetes 13 (+/-1) years. The 50% emptying time (t50) for the liquid meal was shorter in diabetic patients (29.6+/-2.1 min) than in controls (39.2+/-1.9 min; p<0.0005). Accelerated emptying (t50 value below the shortest t50 of controls) was evidenced in 14/20 patients and delayed emptying (t50 value exceeding the upper t50 of controls) in none. Patients with accelerated GER were comparable for BMI, diabetes duration, HbA1c and fasting glycaemia to those with normal GER. Rapid GER for liquids was found in the presence or absence of autonomic neuropathy. Seven of the patients with rapid emptying of the liquid meal were reassessed using a solid meal. Only one patient demonstrated rapid emptying of the solid meal, which was normal in 3 and delayed in 3 patients. In conclusion, accelerated GER can be found in long-term Type 2 diabetes but there is no concordance between GER of a liquid and a solid meal.
authors.affiliation: Department of Internal Medicine, Vrije Universiteit Brussel, Brussels, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Weytjens
authors.forename: B
authors.initials: B
authors.lastname: Keymeulen
authors.forename: C
authors.initials: C
authors.lastname: Van Haleweyn
authors.forename: G
authors.initials: G
authors.lastname: Somers
authors.forename: A
authors.initials: A
authors.lastname: Bossuyt
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000503:physiopathology; D003930:Diabetic Retinopathy / Q000503:physiopathology; D002149:Energy Intake; D005260:Female; D005746:Gastric Emptying; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D019275:Radiopharmaceuticals; D012016:Reference Values; D013671:Technetium Tc 99m Sulfur Colloid
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D019275:Radiopharmaceuticals; D013671:Technetium Tc 99m Sulfur Colloid