Intrafamilial association of pericentric inversion of chromosome 9, inv (9)(p11-q21), and rapid cycling bipolar disorder.
Association of a chromosome aberration and psychiatric disorder can be useful in highlighting a genomic region that can be profitably explored further using positional cloning. We report the case of a father and daughter both of whom have bipolar disorder II and a pericentric inversion of chromosome 9.
McCandless
F
F
Department of Psychiatry, University of Birmingham, Queen Elizabeth Psychiatric Hospital, UK.
Jones
I
I
Harper
K
K
Craddock
N
N
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001714:Bipolar Disorder / Q000150:complications / Q000235:genetics*; D002648:Child; D007446:Chromosome Inversion; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics / Q000648:ultrastructure*; D019052:Depression, Postpartum / Q000209:etiology; D003865:Major Depressive Disorder / Q000235:genetics; D004410:Dyslexia; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000150:complications; D008297:Male; D010375:Pedigree