title: [Fetal acidemia and neonatal encephalopathy].
abstract: OBJECTIVE
  The purpose of this study was to determine the significance of fetal acidemia for newborn encephalopathy (NEP) and for the combination of NEP and multiorgan system dysfunction (MOS). In particular the influence of acidemia will be contrasted with criteria of pregnancy and delivery.
  
  
  METHODS
  248 infants delivered with cord umbilical arterial pH < 7.15 (UApH) were retrospectively studied. Infants with similar or identical neonatal characteristics formed different groups: unaffected neonatal development, NEP, NEMO (NEP combined with MOS), other diseases, infection, exitus letalis. Statistics and calculations were done by means of factor analysis, univariate analysis, Student-Newman-Keuls-test, and Chi 2-test (p < 0.05).
  
  
  RESULTS
  Twenty seven infants with UApH < 7.15 suffered from NEP. NEP in combination with MOS occurred in 11 cases. There was no relationship between the degree of acidemia and a single NEP. Infants with NEMO differ from all other groups in their mean UApH (p < 0.05). The Apgar scores 1 min and 5 min (A1, A5) separated newborns with unaffected neonatal development from all other groups (p < 0.05). UApH-differences in the group: NEMO resulted from a combination of acute intranatal fetal distress and operative delivery and a combination of A1, A5, preterm delivery, and pathologic CTG (p < 0.01).
  
  
  CONCLUSIONS
  The degree of acidemia impacts the occurrence of NEMO. However, UApH alone does not predict this combination of characteristics. The Apgar score should be taken into account to evaluate an acidemic UApH. In case of acidemia complex factors of pregnancy and delivery are associated with an increased risk of NEMO.
authors.affiliation: Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden.
authors.forename: A
authors.initials: A
authors.lastname: Riehn
authors.forename: C
authors.initials: C
authors.lastname: Petzold
authors.forename: E
authors.initials: E
authors.lastname: Kuhlisch
authors.forename: W
authors.initials: W
authors.lastname: Distler
mesh_terms: D000138:Acidosis / Q000151:congenital* / Q000175:diagnosis; D001034:Apgar Score; D001925:Brain Damage, Chronic / Q000151:congenital* / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D005316:Fetal Distress / Q000175:diagnosis; D005865:Gestational Age; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007231:Infant, Newborn; D009102:Multiple Organ Failure / Q000151:congenital / Q000175:diagnosis; D011247:Pregnancy; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors
vernacular_title: Fetale Azidämie und Neugeborenenenzephalopathie.