title: Mechanism of increased serum cytokeratin 19 fragment levels in patients with diabetic nephropathy as a model of chronic renal failure.
abstract: We examined serum and urinary cytokeratin 19 fragment (CYFRA 21-1) levels in patients with diabetic nephropathy as a model of chronic renal failure, to investigate the mechanism of increased serum CYFRA 21-1 levels in chronic renal failure. Serum and urinary CYFRA 21-1 levels in non-insulin-dependent diabetes mellitus (NIDDM) patients with abnormal urinary immunoglobulin G (IgG) levels (>1.1 mg/g x Cr, n=126) were higher than those with normal urinary IgG levels. In NIDDM patients with normal urinary IgG levels (n=81); the urinary albumin or transferrin levels were not related to serum or urinary CYFRA 21-1 levels. We speculate that the increased serum CYFRA 21-1 levels contribute to metabolic abnormality in the kidney itself rather than the decreased urinary excretion per se, and that increased urinary CYFRA 21-1 levels are found in advanced cases of diabetic nephropathy with destruction of the size barrier.
authors.affiliation: Fifth Department of Internal Medicine, Tokyo Medical College, Ibaraki.
authors.forename: K
authors.initials: K
authors.lastname: Kashiwabara
authors.forename: K
authors.initials: K
authors.lastname: Kishi
authors.forename: H
authors.initials: H
authors.lastname: Nakamura
authors.forename: H
authors.initials: H
authors.lastname: Yagyu
authors.forename: K
authors.initials: K
authors.lastname: Kobayashi
authors.forename: O
authors.initials: O
authors.lastname: Watanabe
authors.forename: T
authors.initials: T
authors.lastname: Matsuoka
mesh_terms: D000419:Albuminuria / Q000150:complications / Q000652:urine; D000951:Antigens, Neoplasm / Q000097:blood* / Q000652:urine; D014408:Biomarkers, Tumor / Q000097:blood / Q000652:urine; D003404:Creatinine / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000652:urine; D003928:Diabetic Nephropathies / Q000097:blood* / Q000652:urine; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000652:urine; D015592:Immunoradiometric Assay; D053539:Keratin-19; D007633:Keratins; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000652:urine; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012720:Severity of Illness Index; D014168:Transferrin / Q000652:urine
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D007074:Immunoglobulin G; D053539:Keratin-19; D014168:Transferrin; C102012:antigen CYFRA21.1; D007633:Keratins; D003404:Creatinine