title: Pharmacokinetics of weekly transdermal estradiol controlled delivery system in postmenopausal Chinese.
abstract: OBJECTIVE
  To study Pharmacokinetical profile of weekly transdermal estradiol controlled delivery system (E2-WTCDS) in 18 Chinese postmenopausal women.
  
  
  METHODS
  Single and multiple daily doses of E2-WTCDS were applied to an area of intact skin on the lower abdomen, using Estraderm TTS (E2-TTS) from Ciba-Geigy Company as control. E2 concentration in serum was measured by RIA.
  
  
  RESULTS
  Cmax 38 +/- 5 ng.L-1, Tmax 22 +/- 5 h, AUC 5651 +/- 386 ng.h.L-1, Cmax(SS) 44 +/- 7 ng.L-1, Cmax(SS) 35 +/- 4 ng.L-1, Fl 0.22 +/- 0.10. The relative bioavailability of E2-WTCDS was comparable to E2-TTS during the same period of system application.
  
  
  CONCLUSIONS
  E2-WTCDS maintained relatively constant and effective serum estradiol concentrations and is suitable for once-weekly application.
authors.affiliation: Institute of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou, China.
authors.forename: G S
authors.initials: GS
authors.lastname: Chen
authors.forename: M Y
authors.initials: MY
authors.lastname: Zhang
authors.forename: Q
authors.initials: Q
authors.lastname: Wang
authors.forename: J C
authors.initials: JC
authors.lastname: Ye
mesh_terms: D000279:Administration, Cutaneous; D019540:Area Under Curve; D001682:Biological Availability; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D004958:Estradiol / Q000008:administration & dosage / Q000493:pharmacokinetics*; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause / Q000378:metabolism*
chemical_list: D003692:Delayed-Action Preparations; D004958:Estradiol