title: Nitric oxide synthase containing neurons in the ventral lateral geniculate of the rat project to the optic pretectal nuclei.
abstract: We combined fluorescent tracing with immunohistochemistry to examine nitric oxide synthase (NOS) containing neurons in the rat ventral lateral geniculate nucleus (vLGN). NOS immunopositive neurons in vLGN had a similar appearance to previously described NADPH-d positive neurons. The majority (96%) of the NOS immunopositive neurons in vLGN projected to the pretectal nuclei and these represented 16% of all the vLGN neurons that project to the pretectal nuclei. No NOS immunopositive neurons projected to the superior colliculus. Co-localization of NADPH-d and gamma-aminobutyric acid (GABA) has been reported in vLGN neurons but we found few cells containing both NOS and GABA.
authors.affiliation: Department of Anatomy and W.M. Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco 94143-0452, USA.
authors.forename: X W
authors.initials: XW
authors.lastname: Meng
authors.forename: P T
authors.initials: PT
authors.lastname: Ohara
authors.forename: H J
authors.initials: HJ
authors.lastname: Ralston
mesh_terms: D000818:Animals; D001370:Axonal Transport / Q000187:drug effects; D005456:Fluorescent Dyes / Q000494:pharmacology; D005829:Geniculate Bodies / Q000737:chemistry / Q000166:cytology* / Q000201:enzymology; D007150:Immunohistochemistry; D008297:Male; D008845:Microinjections; D009252:NADPH Dehydrogenase / Q000032:analysis; D009474:Neurons / Q000737:chemistry / Q000166:cytology* / Q000201:enzymology*; D019001:Nitric Oxide Synthase / Q000032:analysis*; D052248:Nitric Oxide Synthase Type I; D051381:Rats; D017207:Rats, Sprague-Dawley; D013266:Stilbamidines; D013477:Superior Colliculi / Q000737:chemistry / Q000166:cytology* / Q000201:enzymology; D005680:gamma-Aminobutyric Acid / Q000032:analysis
chemical_list: C049774:2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt; D005456:Fluorescent Dyes; D013266:Stilbamidines; D005680:gamma-Aminobutyric Acid; D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I; C496322:Nos1 protein, rat; D009252:NADPH Dehydrogenase