Synthesis of beta-D-arabinofuranosyl-1-monophosphoryl polyprenols: examination of their function as mycobacterial arabinosyl transferase donors.
A convenient synthetic strategy has been developed to produce libraries of beta-D-arabinofuranosyl-monophosphorylpolyprenol. Those containing C50 and C55 polyprenols were the most active as donors for the cell-free synthesis of the arabinans of mycobacterial cell walls.
Lee
R E
RE
Department of Microbiology, Colorado State University, Fort Collins 80523-1677, USA.
Brennan
P J
PJ
Besra
G S
GS
D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002250:Carbon Radioisotopes; D002473:Cell Wall; D002474:Cell-Free System; D005419:Flavonoids; D005685:Galactans / Q000096:biosynthesis; D006017:Glycolipids / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D007553:Isotope Labeling / Q000379:methods; D008351:Mannans / Q000096:biosynthesis; D009161:Mycobacterium / Q000201:enzymology*; D010430:Pentosyltransferases / Q000378:metabolism*; D010636:Phenols / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D059808:Polyphenols; D013329:Structure-Activity Relationship; D013379:Substrate Specificity; D013403:Sugar Phosphates / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism
D000995:Antitubercular Agents; D002250:Carbon Radioisotopes; D005419:Flavonoids; D005685:Galactans; D006017:Glycolipids; D007202:Indicators and Reagents; D008351:Mannans; D010636:Phenols; D011108:Polymers; D059808:Polyphenols; D013403:Sugar Phosphates; C012189:arabinomannan; D010430:Pentosyltransferases; C101967:arabinosyltransferase; C005653:arabinogalactan