Clinical islet cell transplantation. Are we there yet?
Diabetes mellitus is perhaps the most devastating chronic disease of all time. A brief history of the evolution of treatment modalities is provided, culminating in the rationale for the physiologic replacement of a functioning beta-cell mass by transplantation. Vascularized pancreas transplantation is discussed briefly as an introduction to the transplantation of the isolated islet. A detailed review of the current state of human islet transplantation for the cure of diabetes is then described. Finally, areas for future development are highlighted.
Rosenberg
L
L
Department of Surgery, McGill University, Montreal, Canada.
D003920:Diabetes Mellitus / Q000601:surgery*; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007515:Islets of Langerhans / Q000098:blood supply / Q000187:drug effects / Q000294:innervation; D016381:Islets of Langerhans Transplantation / Q000276:immunology / Q000639:trends; D016035:Pancreas Transplantation; D012042:Registries
D007166:Immunosuppressive Agents