title: Polyurethane-coated Dacron-covered stent-grafts for TIPS: results in swine.
abstract: OBJECTIVE
  To evaluate shunt patency after placing a new polyurethane-coated Dacron-covered spiral Z stent-graft to create a transjugular intrahepatic portosystemic shunt (TIPS).
  
  
  METHODS
  TIPS stent-grafts were placed in six young swine, using polyurethane-coated, Dacron-covered spiral Z stent-grafts. Animals were followed weekly by transhepatic portal venography until shunt occlusion or up to 6 weeks, then were sacrificed for gross and histologic evaluation.
  
  
  RESULTS
  Five of six TIPS stent-grafts were found to be occluded by 3 weeks and none were patent at 6 weeks. Histologic evaluation demonstrated a marked foreign body reaction with superimposed thrombosis occluding the graft lumen.
  
  
  CONCLUSIONS
  Polyurethane-coated Dacron-covered stent-grafts do not improve TIPS patency.
authors.affiliation: Dotter Interventional Institute, Oregon Health Sciences University, Portland 97201, USA.
authors.forename: R
authors.initials: R
authors.lastname: Bloch
authors.forename: D
authors.initials: D
authors.lastname: Pavcnik
authors.forename: B T
authors.initials: BT
authors.lastname: Uchida
authors.forename: A
authors.initials: A
authors.lastname: Krajina
authors.forename: T
authors.initials: T
authors.lastname: Kamino
authors.forename: H
authors.initials: H
authors.lastname: Timmermans
authors.forename: M
authors.initials: M
authors.lastname: Loriaux
authors.forename: P
authors.initials: P
authors.lastname: Hulek
mesh_terms: D000818:Animals; D020099:Coated Materials, Biocompatible; D004195:Disease Models, Animal; D006085:Graft Survival; D008422:Materials Testing; D011093:Polyethylene Terephthalates; D011140:Polyurethanes; D011169:Portal Vein / Q000000981:diagnostic imaging / Q000473:pathology; D019168:Portasystemic Shunt, Transjugular Intrahepatic / Q000295:instrumentation* / Q000379:methods; D011172:Portography; D015607:Stents; D013552:Swine
chemical_list: D020099:Coated Materials, Biocompatible; D011093:Polyethylene Terephthalates; D011140:Polyurethanes