Triple helix stabilization properties of oligonucleotides containing 8-amino-2'-deoxyguanosine.
Analysis of the Hoogsteen base pairs of guanine and 8-aminoguanine with cytosine in the gase phase shows a strong stabilization of the 8-aminoguanine.cytosine base pair due to the formation of an extra H-bond. Melting profiles of oligonucleotides carrying 8-amino-2'-deoxyguanosine confirm the triple helix stabilization properties of 8-aminoguanine.
Güimil García
R
R
European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Bachi
A
A
Eritja
R
R
Luque
F J
FJ
Orozco
M
M
D003849:Deoxyguanosine / Q000737:chemistry*; D004355:Drug Stability; D006147:Guanine / Q000031:analogs & derivatives* / Q000737:chemistry; D006860:Hydrogen Bonding; D009841:Oligonucleotides / Q000737:chemistry*
D009841:Oligonucleotides; C033495:8-aminoguanine; D006147:Guanine; D003849:Deoxyguanosine