Springs and zippers: coiled coils in SNARE-mediated membrane fusion.
A conserved molecular machinery based on SNARE proteins catalyzes most, if not all, cellular membrane fusion events. A flurry of recent biophysical studies have established a detailed molecular picture of the core SNARE complex. Structural and biochemical analysis of the SNARE machinery is rapidly advancing our understanding of the specificity, regulation and protein catalysis of membrane fusion.
Harbury
P A
PA
Department of Biochemistry Beckman B437 Stanford University Stanford CA 94305 USA. harbury@cmgm.stanford.edu
D002352:Carrier Proteins / Q000737:chemistry / Q000502:physiology*; D002384:Catalysis; D008561:Membrane Fusion; D008565:Membrane Proteins / Q000737:chemistry / Q000502:physiology*; D011487:Protein Conformation
D002352:Carrier Proteins; D008565:Membrane Proteins