Papillary squamotransitional cell carcinoma of the uterine cervix: an advanced stage disease despite superficial location: report of two cases and review of the literature.
Papillary carcinoma of the uterine cervix with features reminiscent of transitional cell carcinoma of urothelial origin is a poorly recognized subtype of cervical carcinoma. This tumour has a propensity for late metastasis and local recurrence in spite of the fact that histologically it could be misinterpreted as cervical intraepithelial neoplasia grade 3 (CIN3) with a papillary configuration or as a squamous papilloma. In this report we describe two examples of papillary squamous/transitional carcinoma of the cervix with literature review. The results indicate that this tumour occurs mainly in postmenopausal women, is potentially aggressive and presents at a more advanced stage inspite of the histological appearance suggesting a superficial or early invasive lesion.
Al-Nafussi
A I
AI
Department of Pathology, The University of Edinburgh, UK.
Al-Yusif
R
R
D000368:Aged; D001707:Biopsy, Needle; D002278:Carcinoma in Situ / Q000175:diagnosis; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D014626:Vaginal Smears