CD43 is associated with tyrosine kinase activity in human neutrophils.
CD43 appears to be involved in signal transduction, however, the mechanism of this function is unknown. Protein kinase activity was detected in neutrophils associated with CD43. Most of the protein kinase activity associated with these antigens was tyrosine kinase activity. The src family kinases lyn and hck were found to account for much of the associated tyrosine kinase activity. The data suggest that associated tyrosine kinase activity may play a role in signal transduction via CD43 to regulate other cell functions.
Skubitz
K M
KM
Department of Medicine, The University of Minnesota Medical School, Minneapolis 55455, USA. skubi001@tc.umn.edu
Campbell
K D
KD
Skubitz
A P
AP
D015703:Antigens, CD; D006801:Humans; D051917:Leukosialin; D009504:Neutrophils / Q000201:enzymology* / Q000276:immunology; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D012795:Sialoglycoproteins / Q000502:physiology*; D015398:Signal Transduction / Q000276:immunology; D019061:src-Family Kinases / Q000378:metabolism
D015703:Antigens, CD; D051917:Leukosialin; C465014:SPN protein, human; D012795:Sialoglycoproteins; D011505:Protein-Tyrosine Kinases; D019061:src-Family Kinases