Glucose plus insulin infusion improves cerebral outcome after asphyxial cardiac arrest.
Hyperglycemia before ischemia worsens cerebral outcome. The aim of this study was to determine the cerebral effects of giving glucose with or without insulin after asphyxial cardiac arrest. Rats underwent 8 min of asphyxial cardiac arrest. After arrest, Group 1 received NaCl; Group 2, insulin; Group 3, glucose; and Group 4, glucose plus insulin, all intravenously. Neurological deficit (ND) scores were 14+/-10%, 22+/-12%, 12+/-10% and 2+/-2% in Groups 1-4, respectively, 72 h after reperfusion. Overall histological damage (HD) scores were 4, 2, 3 and 1, respectively. Group 4 fared significantly better than group 1 on both scores. Glucose after asphyxial cardiac arrest in rats produces no increased brain damage while glucose plus insulin improves cerebral outcome.
Katz
L M
LM
Department of Anesthesiology, Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, USA.
Wang
Y
Y
Ebmeyer
U
U
Radovsky
A
A
Safar
P
P
D000818:Animals; D001237:Asphyxia / Q000188:drug therapy* / Q000503:physiopathology; D001786:Blood Glucose; D001794:Blood Pressure; D001921:Brain / Q000098:blood supply / Q000378:metabolism; D016887:Cardiopulmonary Resuscitation; D005947:Glucose / Q000494:pharmacology*; D006323:Heart Arrest; D006863:Hydrogen-Ion Concentration; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D002534:Hypoxia, Brain / Q000188:drug therapy* / Q000503:physiopathology; D007328:Insulin / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D005947:Glucose