Cerebral candidiasis in a child 1 year after leukaemia.
We describe an unusual case of a late presentation of a fungal brain abscess in a non-neutropenic child 1 year after completing chemotherapy for M5 acute myeloid leukaemia (AML). Biopsy of the mass identified candidal hyphae and the patient was treated with 5 mg/kg of liposomal amphotericin B for 6 weeks. The lesion resolved completely and the child remains well 2 years later. Invasive fungal infection should be included in the differential diagnosis of unexplained symptoms in patients who have previously received intensive chemotherapy.
Tweddle
D A
DA
Department of Child Health, Royal Victoria Infirmary, University of Newcastle, Newcastle upon Tyne.
Graham
J C
JC
Shankland
G S
GS
Kernahan
J
J
D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000009:adverse effects; D001922:Brain Abscess / Q000209:etiology*; D002177:Candidiasis / Q000209:etiology*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000188:drug therapy*
D000935:Antifungal Agents; D000970:Antineoplastic Agents; D000666:Amphotericin B