title: Synthesis and immunosuppressive activity of ruthenium complexes.
abstract: The syntheses and immunosuppressive activity of ruthenium complexes are described. One of the complexes (1a) was shown to be a potent inhibitor of human T-lymphocyte proliferation with an IC50 of 5 nM. The activity of these complexes compares favorably to the well known immunosuppressants Cyclosporin A and Rapamycin.
authors.affiliation: Procept, Inc., Cambridge, MA 02139, USA.
authors.forename: C M
authors.initials: CM
authors.lastname: Bastos
authors.forename: K A
authors.initials: KA
authors.lastname: Gordon
authors.forename: T D
authors.initials: TD
authors.lastname: Ocain
mesh_terms: D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D006801:Humans; D007166:Immunosuppressive Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D012428:Ruthenium / Q000737:chemistry*; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects
chemical_list: D007166:Immunosuppressive Agents; D012428:Ruthenium