Primary cardiac lymphoma in an immunocompetent woman.
We report a fatal primary cardiac non-Hodgkin's lymphoma in a 62 years old immunocompetent woman presenting with tamponade and complete atrioventricular block. CT-scan, echocardiography and autopsy examination showed a tumor largely infiltrating the heart without extracardiac involvement. A surgical biopsy revealed high grade B-cell non-Hodgkin's lymphoma with a misleading myelomonocytic CD68 (KPI) expression. Polymerase Chain Reaction analysis revealed a clonal rearrangement of the immunoglobulin heavy chain gene and confirmed the B-cell origin of the lymphoma. Our report also emphasizes the role of immunohistochemical and molecular techniques in the diagnosis.
Begueret
H
H
Department of Pathology, Hôpital du Haut-Lévêque, Bordeaux, France.
Labouyrie
E
E
Dubus
P
P
Sempe
S
S
Goussot
J F
JF
Besse
P
P
De Mascarel
A
A
Merlio
J P
JP
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D005260:Female; D006327:Heart Block / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D006338:Heart Neoplasms / Q000150:complications / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000150:complications / Q000473:pathology* / Q000503:physiopathology*; D008875:Middle Aged; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; C067980:CD68 antigen, human; D000097382:CD68 Molecule