title: Synthesis and in vitro cytotoxicity of 3- or 4-dialkylaminomethyl-1-azaanthraquinones.
abstract: Six 3-dialkylaminomethyl-1-azaanthraquinones and five 4-dialkylaminomethyl-1-azaanthraquinones were synthesized and evaluated in vitro cytotoxicity against four human cancer cell lines. The compounds retained much of their cytotoxic activity against the multi-drug-resistant cell line (KB-V-1) as shown by resistance index.
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju, Korea.
authors.forename: H
authors.initials: H
authors.lastname: Lee
authors.forename: J Y
authors.initials: JY
authors.lastname: Choi
authors.forename: S I
authors.initials: SI
authors.lastname: Lee
authors.forename: S S
authors.initials: SS
authors.lastname: Hong
authors.forename: J
authors.initials: J
authors.lastname: Cho
authors.forename: Y H
authors.initials: YH
authors.lastname: Kim
mesh_terms: D000880:Anthraquinones / Q000138:chemical synthesis / Q000627:therapeutic use* / Q000633:toxicity; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001372:Aza Compounds / Q000138:chemical synthesis / Q000627:therapeutic use* / Q000633:toxicity; D004341:Drug Evaluation; D006801:Humans; D014407:Tumor Cells, Cultured
chemical_list: D000880:Anthraquinones; D000970:Antineoplastic Agents; D001372:Aza Compounds