cDNA cloning, tissue distribution and chromosomal localization of the human ID4 gene.
A cDNA e encoding the human Id4 protein has been isolated from an astrocytoma library. The predicted protein product shares 98% identity with the mouse Id4 protein and is markedly different from that already reported. By FISH analysis, the human ID4 gene was more precisely mapped to chromosome 6p22.3-p23. Northern blot analysis showed that ID4 is mainly expressed in thyroid, brain and fetal tissue and in some nervous system tumor cell lines.
Rigolet
M
M
U383 INSERM, Clinique Maurice Lamy, Hôpital Necker, Université Paris V, France. rigolet@lovelace.infobiogen.fr
Rich
T
T
Gross-Morand
M S
MS
Molina-Gomes
D
D
Viegas-Pequignot
E
E
Junien
C
C
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D001921:Brain / Q000378:metabolism; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000235:genetics / Q000302:isolation & purification; D004268:DNA-Binding Proteins; D005333:Fetus / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D051796:Inhibitor of Differentiation Proteins; D051379:Mice; D008969:Molecular Sequence Data; D009423:Nervous System Neoplasms / Q000235:genetics; D011506:Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D017422:Sequence Analysis, DNA; D013961:Thyroid Gland / Q000378:metabolism; D014157:Transcription Factors; D014407:Tumor Cells, Cultured
D018076:DNA, Complementary; D004268:DNA-Binding Proteins; C490128:ID4 protein, human; C086479:Idb4 protein, mouse; D051796:Inhibitor of Differentiation Proteins; D011506:Proteins; D014157:Transcription Factors