title: Novel antineoplastic agents with efficacy against multidrug resistant tumor cells.
abstract: A novel series of pentafluorobenzenesulfonamides has been shown to inhibit the growth of a variety of human tumor cell lines. Among the cell types against which these agents were evaluated were the multidrug resistant (MDR) cell lines MCF-7/ADR and P388/ADR. The cytotoxic activity of members of this series of compounds was not affected by the multidrug resistant pump in MCF-7/ADR or P388/ADR cells.
authors.affiliation: Tularik Inc., South San Francisco, CA 94080, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Medina
authors.forename: B
authors.initials: B
authors.lastname: Shan
authors.forename: H
authors.initials: H
authors.lastname: Beckmann
authors.forename: R P
authors.initials: RP
authors.lastname: Farrell
authors.forename: D L
authors.initials: DL
authors.lastname: Clark
authors.forename: R M
authors.initials: RM
authors.lastname: Learned
authors.forename: D
authors.initials: D
authors.lastname: Roche
authors.forename: A
authors.initials: A
authors.lastname: Li
authors.forename: V
authors.initials: V
authors.lastname: Baichwal
authors.forename: C
authors.initials: C
authors.lastname: Case
authors.forename: P A
authors.initials: PA
authors.lastname: Baeuerle
authors.forename: T
authors.initials: T
authors.lastname: Rosen
authors.forename: J C
authors.initials: JC
authors.lastname: Jaen
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D004354:Drug Screening Assays, Antitumor; D005464:Fluorobenzenes / Q000494:pharmacology; D006801:Humans; D010641:Phenotype; D013449:Sulfonamides / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D005464:Fluorobenzenes; D013449:Sulfonamides