[Treatment of mucosal leishmaniasis with aminosidine sulfate: results of two year follow-up].
In 1996, 20 of 21 patients with mucosal leishmaniasis, treated in 1994 with aminosidine sulfate, 16mg/kg/day salt, by intramuscular injection for 20 days, were clinically evaluated. One patient died due to disease not related to mucosal leishmaniasis. Seven of 14 patients (66.7% N = 21) who achieved complete remission three months after treatment remained clinically cured 24 months later and seven relapsed in the same period (50% N = 14). Sorological follow-up showed poor correlation with the results of clinical examination.
Romero
G A
GA
Núcleo de Medicina Tropical e Nutrição/Universidade de Brasília. gromero@guarany.cpd.unb.br
Lessa
H A
HA
Orge
M G
MG
Macêdo
V O
VO
Marsden
P D
PD
D000563:Amebicides / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D005500:Follow-Up Studies; D006801:Humans; D007273:Injections, Intramuscular; D007892:Leishmania braziliensis; D007897:Leishmaniasis, Mucocutaneous / Q000188:drug therapy*; D010303:Paromomycin / Q000008:administration & dosage / Q000627:therapeutic use*
D000563:Amebicides; D010303:Paromomycin
Tratamento da leishmaniose mucosa com sulfato de aminosidine: resultados de dois anos de acompanhamento.