title: Increasing incidence and comparison of nalidixic acid-resistant Salmonella enterica subsp. enterica serotype typhimurium isolates from humans and animals.
abstract: We determined the resistance to quinolone of 309 Salmonella enterica subsp. enterica serotype Typhimurium strains isolated from humans and animals (cattle, pigs, or poultry) in 1995 or 1996. Nalidixic acid resistance increased from 8.5% in 1995 to 18.6% in 1996. The highest resistance levels correlated with a mutation at Ser-83 (or Asp-82). All strains remained ciprofloxacin susceptible. Human and animal isolates were compared by pulsed-field gel electrophoresis, and the banding patterns of the human isolates most closely matched those of the bovine isolates.
authors.affiliation: UPRES 12-34 Microbiologie, Faculte de Medecine, Universite de Rennes I, 35033 Rennes, France.
authors.forename: C
authors.initials: C
authors.lastname: Heurtin-Le Corre
authors.forename: P Y
authors.initials: PY
authors.lastname: Donnio
authors.forename: M
authors.initials: M
authors.lastname: Perrin
authors.forename: M F
authors.initials: MF
authors.lastname: Travert
authors.forename: J L
authors.initials: JL
authors.lastname: Avril
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002417:Cattle; D002645:Chickens; D004250:DNA Topoisomerases, Type II / Q000235:genetics; D004269:DNA, Bacterial / Q000032:analysis / Q000235:genetics; D004352:Drug Resistance, Microbial / Q000235:genetics; D016521:Electrophoresis, Gel, Pulsed-Field; D005787:Gene Frequency; D008826:Microbial Sensitivity Tests; D009154:Mutation; D009268:Nalidixic Acid / Q000494:pharmacology*; D012150:Polymorphism, Restriction Fragment Length; D019779:Salmonella enterica / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D013552:Swine
chemical_list: D000890:Anti-Infective Agents; D004269:DNA, Bacterial; D009268:Nalidixic Acid; D004250:DNA Topoisomerases, Type II