[Experimental study on effect of shenyi xieli mixture on nature killer cell activity and lymphocyte reactivity to IL-2 in tumor mice].
OBJECTIVE
To explore therapeutic mechanism of Shengyi Xieli Mixture (SYXLM) on malignant tumor.


METHODS
Chemotherapy, radiotherapy and different doses of SYXLM were used to treat tumor mice [correction of rats].


RESULTS
SYXLM could enhance the nature killer (NK) cell activities of the tumor mice [correction of rats], and this effect was dose dependent (control group 52.70 +/- 6.01, SYXLM No. 1 group 59.01 +/- 10.00, SYXLM No. 2 group 78.33 +/- 10.90, P < 0.01). The NK cell activities of the tumor mice [correction of rats] were inhibited in the chemotherapy group alone, but they were enhanced in the group of chemotherapy combined with SYXLM (P < 0.05), the results were the same in the radiotherapy group alone and the group of radiotherapy combined with SYXLM (P < 0.05). The response of lymphocyte of the tumor mice [correction of rats] to IL-2 was enhanced significantly in SYXLM group compared with the control group. This response was enhanced insignificantly in the group in which radiotherapy combined with the SYXLM.


CONCLUSIONS
The SYXLM could enhance the function of immune system of the tumor mice [correction of rats] and diminish or reduce the side effect of radiotherapy, chemotherapy to the immune system of the tumor mice [correction of rats].
Qian
Y F
YF
Navy General Hospital, Beijing.
Li
B W
BW
Huang
J S
JS
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007376:Interleukin-2 / Q000096:biosynthesis*; D007694:Killer Cells, Natural / Q000276:immunology*; D008223:Lymphoma / Q000276:immunology* / Q000473:pathology; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D011897:Random Allocation; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D014407:Tumor Cells, Cultured
D004365:Drugs, Chinese Herbal; D007376:Interleukin-2