Antibiotic-induced release of bacterial cell wall components in the pathogenesis of sepsis and septic shock: a review.
This article reviews the new criteria for selecting the proper antimicrobial agent and dosage regimen for standard treatment of severe sepsis, with the intention of preventing septic shock. After introducing new concepts on the pathogenesis of sepsis and septic shock, the authors analyze the parameters of betalactam antibacterial activity, the antibiotic-induced release of bacterial endotoxin and the interrelationships between pharmacokinetics and pharmacodynamics of antibiotics in the search for an optimum dosage regimen of antimicrobial mono- or polytherapy for severely ill septic patients admitted to the intensive care unit.
Periti
P
P
Department of Pharmacology, University of Florence, Italy. EIFT@mclink.it
Mazzei
T
T
D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001427:Bacterial Toxins / Q000009:adverse effects*; D002473:Cell Wall / Q000502:physiology; D004352:Drug Resistance, Microbial; D004731:Endotoxins / Q000009:adverse effects / Q000378:metabolism; D006801:Humans; D007769:Lactams; D018579:Patient Selection; D018805:Sepsis / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D012772:Shock, Septic / Q000209:etiology / Q000382:microbiology / Q000517:prevention & control*
D000900:Anti-Bacterial Agents; D001427:Bacterial Toxins; D004731:Endotoxins; D007769:Lactams