Synthesis of 2-hydroxy acid from 2-amino acid by Clostridium butyricum.
Cultures of Clostridium butyricum type strain in synthetic medium supplemented with various L-2-amino acids revealed the presence of the corresponding 2-hydroxy acid. This metabolite is able to produce the polyester poly(2-hydroxyalkanoic acid). The bioconversion is not stereoselective since D-2-amino acids were also converted. Chiral GC analysis demonstrated that only D-enantiomer is formed from L-leucine.
Khelifa
N
N
Laboratoire de Microbiologie, Unité Microbiologie Anaérobie, Faculté des Sciences Pharmaceutiques et Biologiques de Paris, Université René Descartes, France. nasser.khelifa@pharmacie.univ-paris5.fr
Butel
M J
MJ
Rimbault
A
A
D000596:Amino Acids / Q000378:metabolism*; D003013:Clostridium / Q000378:metabolism*; D006880:Hydroxy Acids / Q000378:metabolism*; D008968:Molecular Conformation
D000596:Amino Acids; D006880:Hydroxy Acids