title: [Study and treatment of heart failure require new approaches. Natriuretic peptides can be safe and simple diagnostic and outcome measures].
abstract: Analysis of plasma natriuretic peptides and related propeptide fragments may be a cost-effective aid to diagnostic evaluation and treatment follow-up in cases of heart failure. In diagnostic potential such variables may constitute first-line measures of high negative predictive value, allowing further examination, e.g. by echocardiography, in cases where values are above the respective cut-off levels. However, in many cases evaluation of published reports is rendered difficult by their omission of information on such pre-analytical variables as blood sampling and storage, and drug therapy. Moreover, different analytical methods may yield widely divergent results. Thus, before such assays are introduced in general use, their long-term validity needs to be ensured, for instance by consistency in calibration, and measurements need to be made in representative series of unselected patients for the determination of appropriate cut-off levels.
authors.affiliation: Avdelningen för klinisk kemi och transfusionsmedicin, Sahlgrenska Universitetssjukhuset/Sahlgrenska.
authors.forename: G
authors.initials: G
authors.lastname: Lindstedt
authors.forename: C H
authors.initials: CH
authors.lastname: Bergh
authors.forename: K
authors.initials: K
authors.lastname: Caidahl
authors.forename: R
authors.initials: R
authors.lastname: Ekman
authors.forename: B
authors.initials: B
authors.lastname: Fagerberg
authors.forename: J
authors.initials: J
authors.lastname: Isgaard
authors.forename: P A
authors.initials: PA
authors.lastname: Lundberg
authors.forename: K
authors.initials: K
authors.lastname: Swedberg
authors.forename: T
authors.initials: T
authors.lastname: Wallén
mesh_terms: D000595:Amino Acid Sequence; D009320:Atrial Natriuretic Factor / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D015415:Biomarkers / Q000032:analysis*; D001921:Brain / Q000378:metabolism; D003937:Diagnosis, Differential; D004730:Endothelium, Vascular; D005500:Follow-Up Studies; D006333:Heart Failure / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D008969:Molecular Sequence Data; D045283:Natriuretic Agents / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D011379:Prognosis; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D045283:Natriuretic Agents; D009320:Atrial Natriuretic Factor
vernacular_title: Utredning och behandling av hjärtsvikt söker nya vägar. Natriuretiska peptider kan bli säkert och enkelt mått i diagnostik och behandling.