Soluble CD27 in thyroid disorders.
We measured the soluble cytokine CD27 in a variety of thyroid disorders. Soluble CD27 was increased in untreated Graves' hyperthyroidism and in euthyroid ophthalmopathy. Levels of sCD27 were normal after the establishment of euthyroidism with propylthiouracil (PTU) or radio iodine in primary hypothyroidism, chronic thyroiditis, and the hyperthyroid and euthyroid phases of subacute thyroiditis. Soluble CD27 is a marker for cellular activation as in Graves' hyperthyroidism, but it is not predictive of the outcome of PTU therapy.
Kallio
P
P
Department of Medicine, The Evanston Hospital, Illinois, USA.
Murphy
E D
ED
D000208:Acute Disease; D000328:Adult; D000368:Aged; D013956:Antithyroid Agents / Q000627:therapeutic use; D015415:Biomarkers; D002908:Chronic Disease; D005260:Female; D006111:Graves Disease / Q000097:blood / Q000175:diagnosis; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000175:diagnosis; D007453:Iodide Peroxidase / Q000097:blood; D008297:Male; D008875:Middle Aged; D011441:Propylthiouracil / Q000627:therapeutic use; D011989:Receptors, Thyrotropin / Q000097:blood; D013959:Thyroid Diseases / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy; D013966:Thyroiditis / Q000097:blood / Q000175:diagnosis; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000097:blood*
D013956:Antithyroid Agents; D015415:Biomarkers; D011989:Receptors, Thyrotropin; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7; D011441:Propylthiouracil; D013972:Thyrotropin; D007453:Iodide Peroxidase; D013974:Thyroxine