title: [Bile duct decompression and immune correction in the surgical treatment of mechanical jaundice of non-tumor origin].
abstract: The aims of the study were: 1) to determine optimal duration of bile ducts decompression (BDD) and terms for radical operation performance; 2) to define criteria of effectiveness of the decompression and readiness of the patients for radical surgical treatment; 3) to analyze disorders in liver function and indices of immunoreactivity in relation to the method and duration of BDD; 4) to develop method of immunocompression for increase of effectiveness of BDD. The patients were divided in to three groups. 28 patients of group 1 had duration of jaundice up to 5 days and bilirubinemia up to 86.3 +/- 3.12 mmol/l. 35 patients of group 2 jaundice up to 15 days and bilirubinemia up to 184.7 +/- 4.22 mmol/l. In group 342 patients had bilirubinemia up to 124.4 +/- 2.23 mmol/l and cholangitis. External decompression of bile ducts quickly promotes restoration of drainage function of the liver and normalization of biochemical indexes. Restoration of immunological indexes in groups 2 and 3 is progressing slowly and demands immunocorrection. Indexes of immunoreactivity and biochemical data of functional status of the liver could serve as criteria of effectiveness of bile ducts decompression and possibility of radical surgical treatment. Regional immunocorrection is indicated for the patients' preparation for surgery.
authors.forename: A V
authors.initials: AV
authors.lastname: Shabunin
authors.forename: V I
authors.initials: VI
authors.lastname: Tarabrin
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Malyshev
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D014670:Ampulla of Vater / Q000601:surgery; D001652:Bile Ducts; D002761:Cholangitis / Q000150:complications; D017081:Cholecystectomy, Laparoscopic; D002779:Cholestasis / Q000209:etiology / Q000276:immunology / Q000601:surgery*; D019299:Decompression, Surgical; D004151:Dipeptides; D004322:Drainage; D004724:Endoscopy; D005260:Female; D042882:Gallstones / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D000276:Adjuvants, Immunologic; D004151:Dipeptides; D010455:Peptides; C060736:thymogen
vernacular_title: Dekompressiia zhelchevyvodiashchikh puteĭ i immunokorrektsiia pri khirurgicheskom lechenii mekhanicheskoĭ zheltukhi neopukholevogo geneza.