Requirement for IL-13 independently of IL-4 in experimental asthma.
The pathogenesis of asthma reflects, in part, the activity of T cell cytokines. Murine models support participation of interleukin-4 (IL-4) and the IL-4 receptor in asthma. Selective neutralization of IL-13, a cytokine related to IL-4 that also binds to the alpha chain of the IL-4 receptor, ameliorated the asthma phenotype, including airway hyperresponsiveness, eosinophil recruitment, and mucus overproduction. Administration of either IL-13 or IL-4 conferred an asthma-like phenotype to nonimmunized T cell-deficient mice by an IL-4 receptor alpha chain-dependent pathway. This pathway may underlie the genetic associations of asthma with both the human 5q31 locus and the IL-4 receptor.
Grünig
G
G
Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94143, USA.
Warnock
M
M
Wakil
A E
AE
Venkayya
R
R
Brombacher
F
F
Rennick
D M
DM
Sheppard
D
D
Mohrs
M
M
Donaldson
D D
DD
Locksley
R M
RM
Corry
D B
DB
D019264:Adoptive Transfer; D000485:Allergens / Q000276:immunology; D000818:Animals; D001249:Asthma / Q000235:genetics / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D016535:Bronchial Hyperreactivity; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002895:Chromosomes, Human, Pair 5; D020397:Goblet Cells / Q000473:pathology; D006801:Humans; D007141:Immunoglobulin Fc Fragments; D018793:Interleukin-13 / Q000037:antagonists & inhibitors / Q000235:genetics / Q000494:pharmacology / Q000502:physiology*; D053661:Interleukin-13 Receptor alpha1 Subunit; D015847:Interleukin-4 / Q000235:genetics / Q000494:pharmacology / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000276:immunology; D010641:Phenotype; D018123:Receptors, Interleukin / Q000235:genetics / Q000276:immunology / Q000502:physiology; D053660:Receptors, Interleukin-13; D019948:Receptors, Interleukin-4 / Q000235:genetics / Q000502:physiology; D011993:Recombinant Fusion Proteins / Q000494:pharmacology; D018418:Th2 Cells / Q000276:immunology
D000485:Allergens; C508181:IL13RA1 protein, human; C508183:Il13ra1 protein, mouse; D007141:Immunoglobulin Fc Fragments; D018793:Interleukin-13; D053661:Interleukin-13 Receptor alpha1 Subunit; D018123:Receptors, Interleukin; D053660:Receptors, Interleukin-13; D019948:Receptors, Interleukin-4; D011993:Recombinant Fusion Proteins; D015847:Interleukin-4; D010047:Ovalbumin