Synthesis of tools for target identification of the anti-apoptotic compound CGP 3466; Part I.
Immobilized compounds for BIAcore studies and affinity precipitation as well as a fluorescent-labeled compound were prepared in order to identify the molecular target of the anti-apoptotic, neurorescuing compound CGP 3466 (N-methyl-N-propargyl-10-aminomethyl-dibenzo[b,f]oxepin).
Zimmermann
K
K
Novartis Pharma Inc., Basel/Switzerland. Kaspar.Zimmermann@pharma.novartis.com
Roggo
S
S
Kragten
E
E
Fürst
P
P
Waldmeier
P
P
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D002846:Chromatography, Affinity; D005456:Fluorescent Dyes; D006624:Hippocampus / Q000166:cytology; D007202:Indicators and Reagents; D015394:Molecular Structure; D009474:Neurons / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D018696:Neuroprotective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010082:Oxepins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D012642:Selegiline / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D005456:Fluorescent Dyes; D007202:Indicators and Reagents; D018696:Neuroprotective Agents; D010082:Oxepins; C111178:dibenzo(b,f)oxepin-10-ylmethyl-methyl-prop-2-ynyl-amine; D012642:Selegiline