Apoptosis-gene expression in hematopoietic system: normal and pathological conditions (Review).
Gene expression involving apoptosis in the hematopoietic system is reviewed. In normal and hematological disorders, Fas-Fas ligand and tumor necrosis factor-alpha-receptor interaction play a major role in enhancing apoptosis. On the other hand, bcl-2 or certain novel proteins (including FADD, RIP, TRADD and sentrin) prevent apoptosis. Apoptosis is involved in myelodysplastic syndrome and pathogenesis of leukemia. Expression of Fas antigen plays a role in negative regulation of hematopoiesis in the bone marrow as does interferon-gamma.
Hatake
K
K
Division of Hematology, Department of Internal Medicine, Jichi Medical School, Kawachi, Tochigi 329-04, Japan.
Tomizuka
H
H
Ikeda
M
M
Terui
Y
Y
Miura
Y
Y
D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D015870:Gene Expression; D006413:Hematopoietic System; D006801:Humans