title: 1H MR spectroscopy monitoring of changes in choline peak area and line shape after Gd-contrast administration.
abstract: Fifteen percent loss in the peak area of choline containing compounds (Cho) was recently observed in 1H MR spectra of contrast-enhancing tumor at 5-10 min after Gd-contrast administration [Magn. Reson. Med. 37:222-225, 1997]. In this study, chemical shift imaging (CSI, 1500/135 ms PRESS) was used to assess the spectral changes in 47 Gd-enhancing glial brain tumors and metastatic brain tumors measured at 0-5, 5-10, and/or 10-15 min after administration of Gd-contrast. Percent Cho peak area losses measured at these times, 3 +/- 3, 12 +/- 2, and 14 +/- 3 SEM, respectively, coincided with trends of line narrowing and up-field shift of the Cho peak. Significant changes in creatine and N-acetyl acetate signals were not observed. It is concluded that the Gd-induced loss of tumor Cho signal measured after 5 min, typically required for post contrast-MRI and the positioning of the CSI volume on tumor, shows little further change with time, if any.
authors.affiliation: Department of Radiology, Dr. Daniel den Hoed Cancer Center, University Hospital Rotterdam, The Netherlands. sijens@radh.azr.nl
authors.forename: P E
authors.initials: PE
authors.lastname: Sijens
authors.forename: M
authors.initials: M
authors.lastname: Oudkerk
authors.forename: P
authors.initials: P
authors.lastname: van Dijk
authors.forename: P C
authors.initials: PC
authors.lastname: Levendag
authors.forename: C J
authors.initials: CJ
authors.lastname: Vecht
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000556:secondary; D002794:Choline / Q000378:metabolism*; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D005910:Glioma / Q000175:diagnosis / Q000378:metabolism / Q000556:secondary; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods / Q000706:statistics & numerical data; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D016011:Normal Distribution; D013997:Time Factors
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA; D002794:Choline