[The changes of intraerythrocyte calcium metabolism and their responses to nifedipine in patients with essential hypertension].
The erythrocytic activity membrane ATPases, intraerythrocytic calcium concentration ([Ca2+]i), plasma renin activity (PRA), and angiotensin II (AT-II) in 18 essential hypertensive patients (EH) and matched normal controls were determined. In the EH group, Na(+)-K(+)-ATPase, Ca(2+)-ATPase, PRA were much lower than those in the controls, and [Ca2+]i, AT-II were higher. When blood pressure was become normotensive after a course of taking nifedipine therapy, the forementioned parameter alteration restored to approach the normal range, the changes were significnt. [Ca2+]i was positively correlated with MAP, and negatively correlated with PRA and AT-II. The results suggest that the increase erythrocytic membrane ATPase activity and decrease in renin-angiotensin system activity in nifedipine treatment may be another important antihypertensive mechanism besides accompanied with the rectifying of abnormal cellular calcium metabolism.
Lu
G
G
Department of Medicine, Xiangya Hospital, Hunan Medical University, Changsha.
Ou
S
S
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000804:Angiotensin II / Q000097:blood; D001693:Biological Transport, Active; D002118:Calcium / Q000097:blood*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D003692:Delayed-Action Preparations; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage / Q000627:therapeutic use*; D012084:Renin-Angiotensin System
D002121:Calcium Channel Blockers; D003692:Delayed-Action Preparations; D000804:Angiotensin II; D000251:Adenosine Triphosphatases; D009543:Nifedipine; D002118:Calcium