title: Insulin-like growth factor-1 and insulin-like growth factor-binding protein-3 in women with premenstrual syndrome.
abstract: OBJECTIVE
  To determine whether women with premenstrual syndrome (PMS) have aberrations of the GH axis as has been demonstrated in individuals with depression.
  
  
  METHODS
  Prospective trial.
  
  
  METHODS
  Department of Obstetrics and Gynecology, University of California, Los Angeles.
  
  
  METHODS
  After prospective screening, 32 healthy women with PMS and 32 asymptomatic controls completed the study.
  
  
  METHODS
  Subjects completed a daily PMS symptom diary and a Beck Depression Inventory. They underwent phlebotomy 5 days and 12 days after the LH midcycle surge, which was identified with the use of a urinary LH detection kit.
  
  
  METHODS
  Serum levels of insulin-like growth factor-1 (IGF-1), insulin-like growth factor-binding protein-3 (IGFBP-3), E2, and progesterone.
  
  
  RESULTS
  Levels of IGF-1, IGFBP-3, E2, and progesterone did not differ between women with prospectively documented PMS and control subjects.
  
  
  CONCLUSIONS
  Premenstrual syndrome and affective disorder share common symptoms and possibly a common cause. Biochemical markers such as alterations in the somatotropic system often are associated with major depression. Levels of IGF-1 and IGFBP-3 did not differ between women with PMS and control subjects, supporting the concept that PMS and endogenous depression are biologically distinct entities.
authors.affiliation: University of California, Los Angeles Medical Center, Department of Obstetrics and Gynecology, 90095-1740, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Rapkin
authors.forename: M
authors.initials: M
authors.lastname: Cedars
authors.forename: M
authors.initials: M
authors.lastname: Morgan
authors.forename: L
authors.initials: L
authors.lastname: Goldman
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003863:Depression / Q000097:blood* / Q000209:etiology; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D011293:Premenstrual Syndrome / Q000097:blood* / Q000523:psychology; D011374:Progesterone / Q000097:blood
chemical_list: D018972:Insulin-Like Growth Factor Binding Protein 3; D011374:Progesterone; D004958:Estradiol; D007334:Insulin-Like Growth Factor I