title: Segmentation of brain tissue from magnetic resonance images.
abstract: Segmentation of medical imagery is a challenging problem due to the complexity of the images, as well as to the absence of models of the anatomy that fully capture the possible deformations in each structure. The brain is a particularly complex structure, and its segmentation is an important step for many problems, including studies in temporal change detection of morphology, and 3-D visualizations for surgical planning. We present a method for segmentation of brain tissue from magnetic resonance images that is a combination of three existing techniques from the computer vision literature: expectation/maximization segmentation, binary mathematical morphology, and active contour models. Each of these techniques has been customized for the problem of brain tissue segmentation such that the resultant method is more robust than its components. Finally, we present the results of a parallel implementation of this method on IBM's supercomputer Power Visualization System for a database of 20 brain scans each with 256 x 256 x 124 voxels and validate those results against segmentations generated by neuroanatomy experts.
authors.affiliation: Massachusetts Institute of Technology, Artificial Intelligence Laboratory, Cambridge 02139, USA. tkapur@ai.mit.edu
authors.forename: T
authors.initials: T
authors.lastname: Kapur
authors.forename: W E
authors.initials: WE
authors.lastname: Grimson
authors.forename: W M
authors.initials: WM
authors.lastname: Wells
authors.forename: R
authors.initials: R
authors.lastname: Kikinis
mesh_terms: D000465:Algorithms; D019412:Anatomy, Cross-Sectional; D001921:Brain / Q000033:anatomy & histology*; D005583:Fourier Analysis; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D015203:Reproducibility of Results