title: Two cases of hypertrophic cardiomyopathy with coronary vasospasm.
abstract: Chest pain in patients with hypertrophic cardiomyopathy seems to be caused by relative myocardial ischemia due to the left ventricular outflow pressure gradient and myocardial hypertrophy. However, in 2 cases of hypertrophic cardiomyopathy chest pain was associated with coronary vasospasm. Thus, chest pain in these cases was decreased not by a beta-blocker but by isosorbide dinitrate and a calcium antagonist. Because beta-blockers are commonly used for hypertrophic obstructive cardiomyopathy and chest pain may be aggravated by beta-blockers in patients with coronary vasospasm, a combination of beta-blocker, isosorbide dinitrate and calcium antagonist was necessary for this hypertrophic cardiomyopathy with variant angina.
authors.affiliation: Department of Cardiology, Tenri Hospital, Tenri City, Nara, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Konishi
authors.forename: H
authors.initials: H
authors.lastname: Kondou
authors.forename: T
authors.initials: T
authors.lastname: Tamura
authors.forename: C
authors.initials: C
authors.lastname: Izumi
authors.forename: M
authors.initials: M
authors.lastname: Inoko
authors.forename: S
authors.initials: S
authors.lastname: Kitaguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Himura
authors.forename: K
authors.initials: K
authors.lastname: Iga
authors.forename: H
authors.initials: H
authors.lastname: Gen
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000368:Aged; D000788:Angina Pectoris, Variant / Q000188:drug therapy* / Q000209:etiology*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications* / Q000188:drug therapy; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D003329:Coronary Vasospasm / Q000150:complications* / Q000188:drug therapy; D004110:Diltiazem / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004562:Electrocardiography; D006801:Humans; D007548:Isosorbide Dinitrate / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged
chemical_list: D000319:Adrenergic beta-Antagonists; D002121:Calcium Channel Blockers; D002317:Cardiovascular Agents; D004110:Diltiazem; D007548:Isosorbide Dinitrate