title: No association between the serotonin transporter-linked promoter region polymorphism and either schizophrenia or density of the serotonin transporter in human hippocampus.
abstract: BACKGROUND
  Allelic association case-control analysis of a deletion/insertion polymorphism in the serotonin transporter-linked polymorphic region (5-HTTLPR) has suggested associations with unipolar disorder, bipolar disorder, depression, and Alzheimer's disease. Moreover, the heterozygous long form of the 5-HTTLPR has been associated with increased levels of mRNA for the serotonin transporter (5-HTT) and increased serotonin uptake in lymphoblastic cell lines. This study attempts to determine whether there is an association between 5-HTTLPR genotype and schizophrenia or the binding of [3H]paroxetine to the human hippocampal 5-HTT.
  
  
  METHODS
  DNA from the cerebellum from 58 schizophrenic and 62 control subjects was used to genotype the 5-HTTLPR. In addition, the relationship between 5-HTTLPR genotype and the affinity and density of [3H]paroxetine binding to the hippocampal 5-HTT was assessed.
  
  
  RESULTS
  There were no associations between 5-HTTLPR allotype or genotype and/or the parameters of [3H]paroxetine binding to the hippocampal 5-HTT.
  
  
  CONCLUSIONS
  Our data suggest that 5-HTTLPR genotype neither confers an increased susceptibility for schizophrenia nor dictates the expression of the 5-HTT in the human hippocampus.
authors.affiliation: Rebecca L. Cooper Research Laboratories, Molecular Schizophrenia Division, Mental Health Research Institute of Victoria, Parkville, Australia.
authors.forename: L
authors.initials: L
authors.lastname: Naylor
authors.forename: B
authors.initials: B
authors.lastname: Dean
authors.forename: A
authors.initials: A
authors.lastname: Pereira
authors.forename: A
authors.initials: A
authors.lastname: Mackinnon
authors.forename: A
authors.initials: A
authors.lastname: Kouzmenko
authors.forename: D
authors.initials: D
authors.lastname: Copolov
mesh_terms: D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D016022:Case-Control Studies; D005838:Genotype; D006624:Hippocampus / Q000378:metabolism*; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics* / Q000378:metabolism; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D012559:Schizophrenia / Q000378:metabolism*; D050486:Serotonin Plasma Membrane Transport Proteins
chemical_list: D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins