title: Effects of postprandial hyperlipemia on the vitamin E content of lipoproteins. GERBAP section Lipoprotéines. Groupe d'Evaluation et de Recherche de l'Assistance Publique des Hôpitaux de Paris.
abstract: Delayed postprandial clearance of triglyceride-rich lipoproteins (TGRL) could induce a decrease of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) vitamin E content through its transfer into TGRL. We thus studied lipoprotein vitamin E content during postprandial hypertriglyceridemia induced by a high fat meal without vitamin E supplement. Venous blood was drawn from five healthy male volunteers following a 12 h fast at (t0) then 2 h (t2), 4 h (t4), 6 h (t6) and 8 h (t8) after a 80 g fat meal. In plasma, only TG significantly varied during the postprandial period with a large interindividual variability. Mean composition of lipoproteins in terms of mass was not significantly modified. The amount of vitamin E significantly increased in TGRL and decreased in LDL plus HDL at t4 and t6 relative to t0. Vitamin E content of TGRL and LDL but not of HDL decreased significantly at t4. The mean decrease was 20% (range 5%-54%) for the LDL. LDL- and HDL vitamin E content correlated inversely with plasma TGRL levels. Our data suggest that LDL from subjects with delayed chylomicron clearance could be less protected against oxidation.
authors.affiliation: Service de Biochimie, Hôpital Tenon, Paris, France. remy.couderc@tnn.ap-hop-paris.fr
authors.forename: R
authors.initials: R
authors.lastname: Couderc
authors.forename: J
authors.initials: J
authors.lastname: Peynet
authors.forename: M
authors.initials: M
authors.lastname: Cambillaud
authors.forename: F
authors.initials: F
authors.lastname: Tallet
authors.forename: C
authors.initials: C
authors.lastname: Cosson
authors.forename: G
authors.initials: G
authors.lastname: Lefèvre
authors.forename: V
authors.initials: V
authors.lastname: Atger
mesh_terms: D004041:Dietary Fats / Q000008:administration & dosage; D004912:Erythrocytes / Q000378:metabolism; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood* / Q000737:chemistry; D008077:Lipoproteins, LDL / Q000097:blood* / Q000737:chemistry; D008297:Male; D019518:Postprandial Period; D012016:Reference Values; D014810:Vitamin E / Q000378:metabolism*
chemical_list: D004041:Dietary Fats; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014810:Vitamin E