Modeling the effects of hydroxypropylcellulose in acetaminophen tablet formulation.
The objective of the research described here was to develop a set of predictive models that would be used to show the performance of hydroxypropylcellulose as a pharmaceutical tablet binder. A statistically designed set of experiments was used to relate tablet formulation to functionality. It was found that the binder level affected both hardness and dissolution time. Useful predictive models were generated for tablet hardness and dissolution time as a function of the binder or binder-drug ratio. The optimal formulation can be predicted from this study, and will depend upon the combination of desired hardness and the dissolution time for a particular drug.
Harcum
W W
WW
Hercules Incorporated, Wilmington, DE 19808-1599, USA.
Skinner
G W
GW
Altekar
M
M
Joneja
S K
SK
Barnum
P E
PE
Guo
J H
JH
D000082:Acetaminophen / Q000493:pharmacokinetics*; D018712:Analgesics, Non-Narcotic / Q000493:pharmacokinetics*; D002482:Cellulose / Q000031:analogs & derivatives* / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical; D006244:Hardness; D008954:Models, Biological; D015233:Models, Statistical; D012044:Regression Analysis; D015203:Reproducibility of Results; D012995:Solubility; D013607:Tablets
D018712:Analgesics, Non-Narcotic; D013607:Tablets; D000082:Acetaminophen; D002482:Cellulose; C008079:hydroxypropylcellulose