title: Mechanisms mediating multiple physiological responses to gonadotropin-releasing hormone.
abstract: A central question in endocrinology is how a single ligand interacting with a single receptor can mediate multiple responses. GnRH interaction with receptor offers a prime example, leading to the regulation of synthesis and release of at least three molecules, regulation of target cell responsiveness and receptor number. The present study suggests a molecular model consistent with extant data that provides a mechanism by which this may occur and, further, which allows for coordinate regulation.
authors.affiliation: Department of Physiology and Pharmacology, Oregon Health Sciences University, Portland 97201, USA.
authors.forename: D
authors.initials: D
authors.lastname: Stanislaus
authors.forename: J H
authors.initials: JH
authors.lastname: Pinter
authors.forename: J A
authors.initials: JA
authors.lastname: Janovick
authors.forename: P M
authors.initials: PM
authors.lastname: Conn
mesh_terms: D000818:Animals; D015536:Down-Regulation; D019204:GTP-Binding Proteins / Q000378:metabolism; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism*; D008954:Models, Biological; D011966:Receptors, LHRH / Q000378:metabolism*; D015398:Signal Transduction; D015854:Up-Regulation
chemical_list: D011966:Receptors, LHRH; D007987:Gonadotropin-Releasing Hormone; D019204:GTP-Binding Proteins