title: Changes in the concentration of insulin-like growth factor I and transforming growth factor beta1 in rat femoral bone during growth.
abstract: Our knowledge of the concentration of growth factors in growing bone is limited. In the present study, we examined the developmental changes in the concentrations of insulin-like growth factor I (IGF-I) and transforming growth factor beta (TGF-beta) in the rat femur between weanling and maturity. We show that during the rapid growth phase there is a continuous rise in bone matrix IGF-I and TGF-beta in all compartments of the femoral bone. The association between IGF-I and TGF-beta is not only temporal, but with few exceptions is also observed within the animals of each age class. These data support the hypothesis that IGF-I and TGF-beta play an important role in the growth-associated accumulation of bone mass.
authors.affiliation: Department of Internal Medicine I, University of Heidelberg, Luisenstrasse 5, D-69115, Heidelberg, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Pfeilschifter
authors.forename: J
authors.initials: J
authors.lastname: Erdmann
authors.forename: S
authors.initials: S
authors.lastname: Storch
authors.forename: R
authors.initials: R
authors.lastname: Ziegler
authors.forename: M
authors.initials: M
authors.lastname: Weinreb
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D015519:Bone Density; D005269:Femur / Q000502:physiology*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D051381:Rats; D016212:Transforming Growth Factor beta / Q000378:metabolism*
chemical_list: D016212:Transforming Growth Factor beta; D007334:Insulin-Like Growth Factor I