Growth inhibitory effect of juvenile hormone analogues on epimastigotes of Trypanosoma cruzi.
Several compounds, structurally related to the insect growth regulator Fenoxycarb, exhibited interesting inhibition action to control proliferation of Trypanosoma cruzi, the parasite responsible for Chagas' disease. Some of these drugs were shown to be potent growth inhibitors of this parasite. All of these drugs had previously presented juvenoid activity on several non-related bug species such as Tenebrio molitor, Galleria mellonella, Dysdercus cingulatos, and Pyrrhocoris apterus.
Rodriguez
J B
JB
Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.
Zhong
L
L
Docampo
R
R
Wimmer
Z
Z
Gros
E G
EG
D000818:Animals; D007605:Juvenile Hormones / Q000494:pharmacology*; D007654:Ketoconazole / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014344:Trypanocidal Agents / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects* / Q000254:growth & development
D007605:Juvenile Hormones; D014344:Trypanocidal Agents; D007654:Ketoconazole