Novel cytokine release inhibitors. Part I: Triterpenes.
Tripterine and closely related triterpenoid derivatives as IL-1 beta release inhibitors are discussed.
Huang
F C
FC
Department of Medicinal Chemistry, Rhóne-Poulenc Rorer Central Research, Collegeville, PA 19426, USA.
Chan
W K
WK
Moriarty
K J
KJ
Zhang
D C
DC
Chang
M N
MN
He
W
W
Yu
K T
KT
Zilberstein
A
A
D000818:Animals; D016207:Cytokines / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007249:Inflammation / Q000378:metabolism / Q000517:prevention & control; D015394:Molecular Structure; D051381:Rats; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*
D016207:Cytokines; D014315:Triterpenes