title: Up-regulation of glial cell line-derived neurotrophic factor (GDNF) expression in regenerating muscle fibers in neuromuscular diseases.
abstract: Glial cell line-derived neurotrophic factor (GDNF) has been shown to exert a target-derived trophic factor for motor neurons. Immunohistochemical analyses revealed that expression of GDNF in regeneration muscle fibers was up-regulated in polymyositis (PM) and Duchenne type muscular dystrophy (DMD). Reverse transcriptase polymerase chain reaction (RT-PCR) analyses showed that the full length GDNF was up-regulated in PM and DMD muscle; normal muscle exhibited mostly truncated GDNF. The results indicate that the GDNF expression is regulated in regeneration of human skeletal muscle.
authors.affiliation: Department of Neuromuscular Research, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: A
authors.initials: A
authors.lastname: Hase
authors.forename: B Y
authors.initials: BY
authors.lastname: Kim
authors.forename: Y
authors.initials: Y
authors.lastname: Miyata
authors.forename: I
authors.initials: I
authors.lastname: Nonaka
authors.forename: K
authors.initials: K
authors.lastname: Arahata
authors.forename: C
authors.initials: C
authors.lastname: Akazawa
mesh_terms: D002478:Cells, Cultured; D051100:Glial Cell Line-Derived Neurotrophic Factor; D006801:Humans; D018485:Muscle Fibers, Skeletal / Q000378:metabolism / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology; D009414:Nerve Growth Factors / Q000096:biosynthesis; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D009457:Neuroglia / Q000378:metabolism / Q000502:physiology; D009468:Neuromuscular Diseases / Q000378:metabolism* / Q000503:physiopathology; D012038:Regeneration / Q000502:physiology*; D015854:Up-Regulation / Q000502:physiology*
chemical_list: C495039:GDNF protein, human; D051100:Glial Cell Line-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins