Restricting the flexibility of crosslinked, interfacial peptide inhibitors of HIV-1 protease.
Interfacial peptides of HIV-1 protease were crosslinked with varying length alkyl-chains containing either a single cis or trans double bond, or a triple bond to remove degrees of freedom within the tethers. The synthesis of these compounds and their effects on the activity of HIV-1 protease are described.
Ulysse
L G
LG
Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.
Chmielewski
J
J
D016333:HIV Protease / Q000737:chemistry / Q000187:drug effects*; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D010455:Peptides / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D017320:HIV Protease Inhibitors; D010455:Peptides; D016333:HIV Protease