title: Is the long-term outcome of children following febrile convulsions favorable?
abstract: The study comprised 80 children aged 6 to 9 years with a history of febrile convulsions. A neurological examination, an interview to assess psychiatric anomalies, and a series of neuropsychological tests were performed on patients with previous febrile convulsions and on matched healthy controls. Children with non-febrile seizures or CNS infections were excluded. Recurrence of febrile seizures in the study group was 41% (N=33), 18 children (22%) had prolonged febrile convulsions, six (7.5%) patients and two controls showed discrete neurological abnormalities. Behavioral anomalies were exhibited by 22% of the patients and 6% of the healthy children. The neuropsychological test results did not demonstrate significant differences between the children with febrile convulsions and the healthy controls. However, in children with prolonged febrile convulsions, non-verbal intelligence was found to be significantly lower as compared with children with simple febrile seizures and with controls. None of the other parameters tested yielded any differences between patients and controls. Children with multiple recurrences of febrile convulsions performed poorer in all tests when compared with children with only one febrile seizure or with controls. Other factors such as a positive family history of epilepsy, age at onset of febrile convulsions, or duration of the seizure were not found to be of prognostic significance.
authors.affiliation: Children's Hospital, Mannheim, University of Heidelberg, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Kölfen
authors.forename: K
authors.initials: K
authors.lastname: Pehle
authors.forename: S
authors.initials: S
authors.lastname: König
mesh_terms: D002648:Child; D002658:Developmental Disabilities / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007360:Intelligence; D008297:Male; D009460:Neurologic Examination; D011379:Prognosis; D012008:Recurrence; D003294:Seizures, Febrile / Q000503:physiopathology / Q000523:psychology*