Synthesis and ESR study of new dihydroxamic acid siderophores S as scavengers of hydroxyl radicals.
Five new dihydroxamic acid ligands (L) (8, 10a, 10b, 10c and 13) have been synthesised and characterised as potential chelating agents for iron (Fe3+). The log stability constants of Fe2L3 and FeL+ from Fe3+ and L2- have been estimated to be log beta = 61.96 and log beta 1 = 22.8 respectively. The ability of these compounds to scavenge hydroxyl radicals (oOH) responsible for cell damage have been studied by esr spectroscopy.
Nguyen
M V
MV
Laboratoire de Chimie de Coordination Bioorganique et Bioinorganique, ICMO URA CNRS 1384, Orsay, France.
Nicolas
L
L
Gaudemer
A
A
D004578:Electron Spin Resonance Spectroscopy; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006877:Hydroxamic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D017665:Hydroxyl Radical / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D017262:Siderophores / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D016166:Free Radical Scavengers; D006877:Hydroxamic Acids; D017262:Siderophores; D017665:Hydroxyl Radical