Synthesis of novel antifungal agents (2).
Synthesis of novel cyclohexyl analogs of restricticin using intramolecular radical cyclization and their in vitro and in vivo antifungal activities are described.
Tsukuda
T
T
Department of Medicinal Chemistry, Nippon Roche Research Center, Kamakura, Japan.
Watanabe
M
M
Ontsuka
H
H
Hattori
K
K
Shirai
M
M
Shimma
N
N
D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001232:Aspergillus fumigatus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D051379:Mice; D008826:Microbial Sensitivity Tests
D000935:Antifungal Agents