Study of standard tablet formulation based on fluidized-bed granulation.
In this study, acetaminophen, ascorbic acid, and ethenzamide were selected as model drugs for tableting granules. Agitation and fluidized-bed granulation were carried out at three drug contents of 30, 50, and 70%. Compared with agitation granulation, granules made by fluidized-bed granulation showed superior compressibility with wide formulation allowance for drug type and amount. Fluidized-bed granulation resulted in less granule hardness and greater plastic deformability. The granules had considerable compactness and for tablets containing 70% ethenzamide, prolonged disintegration and dissolution times were noted. These are typical features of granules produced by fluidized-bed granulation.
Sunada
H
H
Faculty of Pharmacy, Meijo University, Nagoya, Japan.
Hasegawa
M
M
Makino
T
T
Sakamoto
H
H
Fujita
K
K
Tanino
T
T
Kokubo
H
H
Kawaguchi
T
T
D000082:Acetaminophen / Q000737:chemistry; D001205:Ascorbic Acid / Q000737:chemistry; D004339:Drug Compounding; D005079:Excipients; D006245:Hardness Tests; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D011208:Powders; D012457:Salicylamides / Q000737:chemistry; D012995:Solubility; D013607:Tablets / Q000592:standards*
D005079:Excipients; D011208:Powders; D012457:Salicylamides; D013607:Tablets; D000082:Acetaminophen; C018935:ethenzamide; D001205:Ascorbic Acid