Synthesis and preliminary evaluation of (S)-2-(4'-carboxycubyl)glycine, a new selective mGluR1 antagonist.
The synthesis and the pharmacological evaluation at metabotropic glutamate receptors of S-2-(4'-carboxy-cubyl)glycine (ACUDA, 9) are described. S-2-(4'-Carboxy-cubyl)glycine is a structurally novel group I selective antagonist for mGluR1 subtype.
Pellicciari
R
R
Istituto di Chimica e Tecnologia del Farmaco, Università degli Studi, Perugia, Italy. rp@unipg.it
Costantino
G
G
Giovagnoni
E
E
Mattoli
L
L
Brabet
I
I
Pin
J P
JP
D001952:Bridged-Ring Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D018691:Excitatory Amino Acid Antagonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005998:Glycine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007295:Inositol Phosphates / Q000096:biosynthesis / Q000378:metabolism; D015394:Molecular Structure; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors*; D014162:Transfection
C116729:2-(4'-carboxycubyl)glycine; D001952:Bridged-Ring Compounds; D018691:Excitatory Amino Acid Antagonists; D007295:Inositol Phosphates; D018094:Receptors, Metabotropic Glutamate; D005998:Glycine