title: Synthesis of a high-mannose-type glycopeptide analog containing a glucose-asparagine linkage.
abstract: The title compound was prepared by enzymatic transfer of oligosaccharide to a synthetic pentapeptide containing the Glc-Asn linkage. The compound was not hydrolyzed by glycoamidases from plant and bacterial sources, but it inhibited both enzymes in the micromolar range. Its activity is compared to other potential inhibitors.
authors.affiliation: Biology Department, Johns Hopkins University, Baltimore, MD 21218, USA.
authors.forename: I L
authors.initials: IL
authors.lastname: Deras
authors.forename: K
authors.initials: K
authors.lastname: Takegawa
authors.forename: A
authors.initials: A
authors.lastname: Kondo
authors.forename: I
authors.initials: I
authors.lastname: Kato
authors.forename: Y C
authors.initials: YC
authors.lastname: Lee
mesh_terms: D000595:Amino Acid Sequence; D001216:Asparagine / Q000737:chemistry*; D002240:Carbohydrate Sequence; D005947:Glucose / Q000737:chemistry*; D006020:Glycopeptides / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008358:Mannose / Q000737:chemistry*; D008969:Molecular Sequence Data; D011487:Protein Conformation
chemical_list: D006020:Glycopeptides; D001216:Asparagine; D005947:Glucose; D008358:Mannose