title: Recombinant factor VIIa in continuous infusion during central line insertion in a child with factor VIII high-titre inhibitor.
abstract: Recombinant factor VIIa (rFVIIa) is a recently added new tool for the treatment of haemophilia patients with inhibitors. A major drawback in the use of rFVIIa is its short half-life, which necessitates frequent bolus injections. Thus the use of rFVIIa in continuous infusion appears to be a good alternative. We describe the use of rFVIIa, administered by continuous infusion with a minipump during the insertion of a central venous catheter in a child with a high-titre factor VIII inhibitor. rFVIIa was administered as an intravenous bolus (90 micrograms kg-1 [4.5 kIU kg-1]), 1 h prior to central line insertion, after which the continuous infusion was immediately started for 5 days. The infusion rate was based on the clearance obtained from a previous pharmacokinetic study. Effective haemostasis and normal healing of surgical incisions were achieved after central line insertion. No local thrombophlebitis nor evidence of generalized activation of the coagulation cascade was observed. Single-dose pharmacokinetic parameter values were clearance (Cl) 34.6 mL h-1 kg-1, volume of distribution (Vd) 40.6 mL kg-1 and mean residence time (MRT) 1.17 h. The recovery was 2.27% U-1 kg-1. rFVIIa showed a monophasic decay. Cl during continuous infusion was 23.4 +/- 6.9 mL h-1 kg-1. The administration of rFVIIa by continuous infusion is effective, safe and more convenient when compared to other clotting factors. Moreover, continuous infusion provides significant economic savings (77% decrease in rFVIIa requirements).
authors.affiliation: Haemophilia Unit, Hospital Vall d'Hebron, Barcelona, Spain. montoro@ar.vhebron.es
authors.forename: J B
authors.initials: JB
authors.lastname: Montoro
authors.forename: C
authors.initials: C
authors.lastname: Altisent
authors.forename: M
authors.initials: M
authors.lastname: Pico
authors.forename: M J
authors.initials: MJ
authors.lastname: Cabañas
authors.forename: M
authors.initials: M
authors.lastname: Vila
authors.forename: L L
authors.initials: LL
authors.lastname: Puig
mesh_terms: D001323:Autoantibodies / Q000096:biosynthesis*; D002405:Catheterization, Central Venous; D002648:Child; D005169:Factor VIII / Q000276:immunology*; D015942:Factor VIIa / Q000627:therapeutic use*; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D007260:Infusion Pumps; D008297:Male; D011994:Recombinant Proteins / Q000627:therapeutic use; D017186:Titrimetry
chemical_list: D001323:Autoantibodies; D006490:Hemostatics; D011994:Recombinant Proteins; D005169:Factor VIII; D015942:Factor VIIa