title: 5-Aminomethylquinoxaline-2,3-diones. Part II: N-aryl derivatives as novel NMDA/glycine and AMPA antagonists.
abstract: Potent antagonists at the glycine-binding site of NMDA receptors, as well as dual antagonists acting also at AMPA receptors have been identified in a series of 5-arylaminomethylquinoxaline-2,3-diones. A study of the structure-activity relationship of these compounds is reported here.
authors.affiliation: Novartis Pharma AG, Basel, Switzerland. yves.auberson@pharma.novartis.com
authors.forename: Y P
authors.initials: YP
authors.lastname: Auberson
authors.forename: P
authors.initials: P
authors.lastname: Acklin
authors.forename: H
authors.initials: H
authors.lastname: Allgeier
authors.forename: M
authors.initials: M
authors.lastname: Biollaz
authors.forename: S
authors.initials: S
authors.lastname: Bischoff
authors.forename: S
authors.initials: S
authors.lastname: Ofner
authors.forename: S J
authors.initials: SJ
authors.lastname: Veenstra
mesh_terms: D018691:Excitatory Amino Acid Antagonists / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D005998:Glycine / Q000378:metabolism*; D011810:Quinoxalines / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors*; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors* / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D018691:Excitatory Amino Acid Antagonists; D011810:Quinoxalines; D018091:Receptors, AMPA; D016194:Receptors, N-Methyl-D-Aspartate; D005998:Glycine