title: Bis(5-hydroxy-2-hydroxymethyl-pyran-4-one-6-yl)methane: a novel ligand for the intracellular mobilisation of ferritin-bound iron.
abstract: The efficacy of a novel tetradentate iron(III) ligand for the in vitro mobilisation of ferritin-bound iron is measured in direct comparison to the clinically approved agents, 1,2-dimethyl-3-hydroxypyridin-4-one and desferrioxamine.
authors.affiliation: Department of Chemistry, University College London, U.K.
authors.forename: R C
authors.initials: RC
authors.lastname: Fox
authors.forename: P D
authors.initials: PD
authors.lastname: Taylor
mesh_terms: D000473:Alkanes / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D002478:Cells, Cultured; D005293:Ferritins / Q000378:metabolism*; D007501:Iron / Q000378:metabolism*; D007502:Iron Chelating Agents / Q000737:chemistry / Q000378:metabolism*; D008024:Ligands; D008099:Liver / Q000166:cytology / Q000378:metabolism; D008297:Male; D011714:Pyrans / Q000737:chemistry / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000473:Alkanes; D007502:Iron Chelating Agents; D008024:Ligands; D011714:Pyrans; C116444:bis(5-hydroxy-2-hydroxymethyl-pyran-4-one-6-yl)methane; D005293:Ferritins; D007501:Iron