Does cholesterol lowering prevent stroke?
The importance of lowering plasma cholesterol to reduce the incidence of coronary events is well established. However, in the prevention of stroke disease, control of hypertension has been the main aim of treatment and lipid lowering therapy has not hitherto been considered to be desirable or necessary. In this review, the evidence from large multicentre trials, imaging studies and meta-analyses is presented. It shows convincingly that HMG-CoA reductase inhibitors (Statins) reduce stroke risk.
Henry
R Y
RY
Department of Medicine, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK.
Kendall
M J
MJ
D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D001161:Arteriosclerosis / Q000517:prevention & control; D002561:Cerebrovascular Disorders / Q000401:mortality / Q000517:prevention & control*; D003952:Diagnostic Imaging; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications / Q000188:drug therapy*; D015201:Meta-Analysis as Topic; D015337:Multicenter Studies as Topic; D017035:Pravastatin / Q000494:pharmacology / Q000627:therapeutic use*; D012307:Risk Factors
D000924:Anticholesteremic Agents; D017035:Pravastatin