Cyclin E overexpression in human gallbladder carcinomas.
The expression of cyclin E, one of the important positive cell cycle regulators, was examined immunohistochemically in gallbladder carcinomas. Cyclin E gene product was detected in 58 (49%) out of 118 cases. The degree of cyclin E expression was not associated with any clinicopathological factor including histology, the depth of tumor invasion, tumor stage and patient prognosis. Cyclin E expression was not correlated with that of p53 protein statistically, whereas it was correlated with the proliferative activity of the tumor cells by PCNA (p<0.05). These results suggested that cyclin E expression may confer progression of gallbladder carcinomas.
Eguchi
N
N
First Department of Internal Medicine, Hiroshima University School of Medicine, Minami-ku, Hiroshima 734-8551, Japan.
Fujii
K
K
Tsuchida
A
A
Yamamoto
S
S
Sasaki
T
T
Kajiyama
G
G
D015415:Biomarkers; D015153:Blotting, Western; D002277:Carcinoma / Q000737:chemistry* / Q000473:pathology; D002453:Cell Cycle; D002455:Cell Division; D019927:Cyclin E / Q000032:analysis*; D018450:Disease Progression; D005706:Gallbladder Neoplasms / Q000737:chemistry* / Q000473:pathology; D006801:Humans; D009363:Neoplasm Proteins / Q000032:analysis*; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis
D015415:Biomarkers; D019927:Cyclin E; D009363:Neoplasm Proteins; D018809:Proliferating Cell Nuclear Antigen