title: [Effect of brain edema on the recurrence pattern of malignant gliomas].
abstract: OBJECTIVE
  To assess the influence of initial preoperative brain edema in malignant gliomas on regrowth patterns.
  
  
  METHODS
  79 patients with histologically verified supratentorial malignant glioma were prospectively studied by magnetic resonance imaging (MRI) before and every 2-3 months after surgery. The median follow-up time was 11 months. We correlated the configuration of the initial vasogenic edema on T2-weighted images with tumor regrowth patterns on contrast-enhanced T1-weighted images.
  
  
  RESULTS
  35/47 tumor regrowths (75%) imitated the initial edema configuration, while 11/47 occurred within the initial tumor bed; in one case tumor recurrence was multilocal.
  
  
  CONCLUSIONS
  In glioblastoma, tumor regrowth patterns correlate positively with the configuration of the initial vasogenic brain edema. The initial, "presurgical" peritumoral edema should thus be considered when planning further treatment.
authors.affiliation: Abteilung Neuroradiologie, Universitätsklinik Heidelberg.
authors.forename: M
authors.initials: M
authors.lastname: Hartmann
authors.forename: O
authors.initials: O
authors.lastname: Jansen
authors.forename: T
authors.initials: T
authors.lastname: Egelhof
authors.forename: M
authors.initials: M
authors.lastname: Forsting
authors.forename: F K
authors.initials: FK
authors.lastname: Albert
authors.forename: K
authors.initials: K
authors.lastname: Sartor
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001929:Brain Edema / Q000503:physiopathology*; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D005910:Glioma / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*
vernacular_title: Einfluss des Hirnödems auf das Rezidivwachstum maligner Gliome.