title: [Patient self-monitoring in follow-up of long-term anticoagulant therapy].
abstract: The CoaguChek system is a new system for simple self-testing of prothrombin time from capillary blood. The instrument works with a measuring principle which is completely new in coagulation: the motion of magnetic micro-particles in an oscillating magnetic field is stopped by the fibrin clot and is detected by a photodetector. The existing data show the analytical and clinical reliability of the system. Determinations for within series imprecision yielded a mean CV of 4.9%. The system is comparable to the comparison method Hepato Quick (y = 1.07 x -0.9% Quick; r = 0.89). Patient self-testing increases the relative time within therapeutic range from 54% to 84%.
authors.affiliation: Boehringer Mannheim GmbH.
authors.forename: R
authors.initials: R
authors.lastname: Zerback
authors.forename: D
authors.initials: D
authors.lastname: Horstkotte
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage* / Q000009:adverse effects; D002138:Calibration; D016903:Drug Monitoring; D004867:Equipment Design; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008134:Long-Term Care; D011183:Postoperative Complications / Q000097:blood / Q000517:prevention & control*; D011517:Prothrombin Time; D012648:Self Care; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation; D013923:Thromboembolism / Q000097:blood / Q000517:prevention & control*
chemical_list: D000925:Anticoagulants
vernacular_title: Patienten-Selbstkontrolle in der Uberwachung der Antikoagulantien-Dauertherapie.