Ascorbic acid-based inhibitors of alpha-amylases.
A series of ascorbic acid and isoascorbic acid derivatives has been evaluated as inhibitors of malt, bacterial, fungal, pancreatic and salivary alpha-amylases using a simple and quick assay procedure. The results demonstrate that the enediol moiety of ascorbic acid is essential for alpha-amylase inhibition. Acylation of the primary and secondary alcohols, and the absolute configuration of the secondary alcohol, do not affect the potency of inhibition.
Abell
A D
AD
Department of Chemistry, University of Canterbury, Christchurch, New Zealand.
Ratcliffe
M J
MJ
Gerrard
J
J
D058833:Antithrombin Proteins; D000991:Antithrombins / Q000737:chemistry* / Q000494:pharmacology; D001205:Ascorbic Acid / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D007700:Kinetics; D000516:alpha-Amylases / Q000037:antagonists & inhibitors*
D058833:Antithrombin Proteins; D000991:Antithrombins; D004791:Enzyme Inhibitors; C116660:L 636619; D000516:alpha-Amylases; D001205:Ascorbic Acid