The role of mixed micelles in drug delivery. I. Solubilization.
The present study revealed that the solubilization of a poorly soluble drug, Amphotericin-B (AmB) can be improved by lipid-bile salt mixed micelles and it was also noted that mixed micellar systems are thermodynamically stable relative to micellar systems. It was observed that the degradation or precipitation of AmB was significantly reduced when stored at 8 degrees C. The mixed micellar systems composed of sodium desoxycholate with monoolein increased the solubilization of AmB by more than seven-fold as compared to nonmicellar systems.
Dangi
J S
JS
Department of Pharmaceutical Sciences, Doctor Harisingh Gour Vishwavidyalaya, Sagar, India.
Vyas
S P
SP
Dixit
V K
VK
D000666:Amphotericin B / Q000737:chemistry*; D016503:Drug Delivery Systems; D008823:Micelles; D012995:Solubility; D013816:Thermodynamics
D008823:Micelles; D000666:Amphotericin B