Resveratrol as a new type of DNA-cleaving agent.
The first demonstration of DNA cleavage by resveratrol '3,5,4'-trihydroxy-trans-stilbene' is presented. Resveratrol mediated relaxation of pBR322 at micromolar concentrations in the presence of Cu2+. Evidence is provided that resveratrol is capable of binding to DNA, and that the Cu(2+)-dependent DNA damage is more likely caused by a copper-peroxide complex rather than by a freely diffusible oxygen species.
Fukuhara
K
K
Division of Organic Chemsitry, National Institute of Health Sciences, Tokyo, Japan.
Miyata
N
N
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D003300:Copper / Q000494:pharmacology; D004247:DNA / Q000187:drug effects*; D004249:DNA Damage; D017665:Hydroxyl Radical; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D013267:Stilbenes; D017665:Hydroxyl Radical; D003300:Copper; D004247:DNA; D000077185:Resveratrol