Regulation of kynurenic acid levels in the developing rat brain.
Several brain-specific mechanisms control the formation of the endogenous excitatory amino acid receptor antagonist kynurenic acid (KYNA) in the adult rat brain. Two of these, dopaminergic neurotransmission and cellular energy metabolism, were examined in the brain of immature (postnatal day 7) rats. The results indicate that during the early postnatal period cerebral KYNA synthesis is exceptionally amenable to modulation by dopaminergic mechanisms but rather insensitive to fluctuations in cellular energy status. These findings may be of relevance for the role of KYNA in the function and dysfunction of the developing brain.
Schwarcz
R
R
Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, USA.
Poeggeler
B
B
Rassoulpour
A
A
Ceresoli-Borroni
G
G
Hodgkins
P S
PS
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D003470:Culture Media; D003913:Dextroamphetamine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D018491:Dopamine Agonists / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism; D007736:Kynurenic Acid / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D003470:Culture Media; D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D007736:Kynurenic Acid; D005947:Glucose; D003913:Dextroamphetamine