[Clinical and experimental studies on composite divitriol infusion in treating tinea manum].
OBJECTIVE
To investigate the effect of Composite Divitriol Infusion (CDI) in treating tinea manum and studying its antimycotic action.


METHODS
CDI was used to treat 139 patients with tinea manum. The experimental study in vivo was done, scanning electron microscopy (SEM) was used to observe the therapeutical effect of CDI.


RESULTS
One hundred and four cases among the 139 patients were cured, 21 were markedly effective, 10 improved and 4 ineffective, the effective rate being 89.9%. Between CDI group and the control group, there was a very significant difference (chi 2 > 12.84, P < 0.005). The antimycotic action of CDI was studied in vitro. Its minimum inhibitory concentrations (MIC) of CDI were about 0.25% for Trichophyton rubrum, and 0.5% for Trichophyton gypseum and Microsporum gypseum. Trichophyton rubrum immersed with CDI show that the mycelia became roughened, deformed and macroconidum became smaller under SEM.


CONCLUSIONS
CDI is valuable in treating tinea manum.
Yang
Z B
ZB
Affiliated Hospital of Hunan College of Traditional Chinese Medicine, Changsha.
Ouyang
H
H
Li
X C
XC
D000293:Adolescent; D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006229:Hand Dermatoses / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008419:Materia Medica / Q000494:pharmacology / Q000627:therapeutic use*; D008864:Microsporum / Q000187:drug effects; D008875:Middle Aged; D014005:Tinea / Q000188:drug therapy* / Q000382:microbiology; D014249:Trichophyton / Q000187:drug effects*
D000935:Antifungal Agents; D004365:Drugs, Chinese Herbal; D008419:Materia Medica