title: Potent HIV protease inhibitors incorporating high-affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere.
abstract: Design and synthesis of a series of very potent nonpeptide HIV protease inhibitors are described. The inhibitors are derived from novel high affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere.
authors.affiliation: Department of Chemistry, University of Illinois at Chicago 60607, USA.
authors.forename: A K
authors.initials: AK
authors.lastname: Ghosh
authors.forename: J F
authors.initials: JF
authors.lastname: Kincaid
authors.forename: W
authors.initials: W
authors.lastname: Cho
authors.forename: D E
authors.initials: DE
authors.lastname: Walters
authors.forename: K
authors.initials: K
authors.lastname: Krishnan
authors.forename: K A
authors.initials: KA
authors.lastname: Hussain
authors.forename: Y
authors.initials: Y
authors.lastname: Koo
authors.forename: H
authors.initials: H
authors.lastname: Cho
authors.forename: C
authors.initials: C
authors.lastname: Rudall
authors.forename: L
authors.initials: L
authors.lastname: Holland
authors.forename: J
authors.initials: J
authors.lastname: Buthod
mesh_terms: D002460:Cell Line; D015195:Drug Design; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis*; D006801:Humans; D008024:Ligands; D008956:Models, Chemical; D019258:Saquinavir / Q000031:analogs & derivatives / Q000737:chemistry; D013449:Sulfonamides / Q000737:chemistry*
chemical_list: D017320:HIV Protease Inhibitors; D008024:Ligands; D013449:Sulfonamides; D019258:Saquinavir