[Comparative study of applying tiaoxue yisui recipe and SSL regimen in treating infantile chronic aplastic anemia and analysis of its therapeutical mechanism].
OBJECTIVE
To explore the effective method in treating infantile chronic aplastic anemia (ICAA) by using traditional Chinese medicine (TCM).


METHODS
Seventy-eight cases of ICAA were observed, 48 of them were treated with Tiaoxue Yisui recipe (treated group), 30 cases were treated with SSL regimen (control group).


RESULTS
The remission rate and total effective rate in treated group were 52.08% and 81.25% respectively, they were higher than those in control group (P < 0.05). After one year treatment the ratio of hemopoietic and non-hemopoietic cells in treated group was higher than that in control group (P < 0.05). The number of megakaryocyte in treated group was more than those in control group (P < 0.05).


CONCLUSIONS
Tiaoxue Yisui recipe could improve the quality of the patient's life. The therapeutical mechanism of the Tiaoxue Yisui recipe might promote the proliferation of hemopoietic stem cells and regulate the immune function.
Yan
F S
FS
Second Affiliated Hospital, Hebei Medical University, Shijiazhuang.
Li
G B
GB
Li
F X
FX
D000293:Adolescent; D000470:Alkaloids / Q000008:administration & dosage; D000741:Anemia, Aplastic / Q000188:drug therapy*; D001381:Azepines; D001856:Bone Marrow Examination; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006576:Heterocyclic Compounds, 4 or More Rings; D006572:Heterocyclic Compounds, Bridged-Ring; D006801:Humans; D007783:Lactones; D007978:Levamisole / Q000008:administration & dosage; D008297:Male; D010880:Piperidines; D011446:Prospective Studies; D013197:Stanozolol / Q000008:administration & dosage
D000470:Alkaloids; D001381:Azepines; D004365:Drugs, Chinese Herbal; D006576:Heterocyclic Compounds, 4 or More Rings; D006572:Heterocyclic Compounds, Bridged-Ring; D007783:Lactones; D010880:Piperidines; D007978:Levamisole; D013197:Stanozolol; C000785:securinine