A concise synthesis and in vitro cytotoxicity of new labdane diterpenes.
A new series of labdane-related diterpenes have been synthesized from (-)-sclareol and assayed in vitro cytotoxicity against mouse and human cancer cells. A key intermediate, homodrimane and furanolabdane derivatives show good in vitro cytotoxicity comparable to those of mitomycin C and adriamycin.
Jung
M
M
Department of Chemistry, Yonsei University, Seoul, Korea.
Ko
I
I
Lee
S
S
Choi
S J
SJ
Youn
B H
BH
Kim
S K
SK
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004224:Diterpenes / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D051379:Mice; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D004224:Diterpenes