Role of zinc in blockade of excitotoxic action of quinolinic acid by picolinic acid.
This study examined whether picolinic acid (PIC) inhibits quinolinic acid (QUIN)-induced excitotoxicity through zinc chelation. Injection of QUIN into the nucleus basalis magnocellularis significantly depleted cortical choline acetyltransferase activity 7 days post injection and PIC inhibited this response. Zinc augmented the QUIN- but not NMDA-induced response. When PIC was co-administered with zinc, PIC failed to attenuate the QUIN-induced response. The inhibition of QUIN-induced cholinergic toxicity by PIC may involve chelation of zinc.
Jhamandas
K H
KH
Department of Pharmacology and Toxicology, Queen's University, Kingston, Ontario, Canada.
Boegman
R J
RJ
Beninger
R J
RJ
Flesher
S
S
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000201:enzymology; D002614:Chelating Agents / Q000737:chemistry; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D018846:Excitatory Amino Acids / Q000819:agonists / Q000037:antagonists & inhibitors; D008297:Male; D010848:Picolinic Acids / Q000494:pharmacology*; D017378:Quinolinic Acid / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D015032:Zinc / Q000737:chemistry / Q000502:physiology*
D002614:Chelating Agents; D018846:Excitatory Amino Acids; D010848:Picolinic Acids; D002795:Choline O-Acetyltransferase; D017378:Quinolinic Acid; D015032:Zinc; C030614:picolinic acid