title: Transdermal delivery of isosorbide 5-mononitrate from a new membrane reservoir and matrix-type patches.
abstract: Isosorbide 5-mononitrate (5-ISMN) has a direct relaxing effect on vascular smooth muscle. In the present study we developed matrix and reservoir-type transdermal patches of 5-ISMN. We investigated the usefulness of a new film-forming material isolated from the roots of Salacia macrosperma to serve as rate-controlling membrane for the reservoir-type patches. Matrix-type patches were formulated using polyvinyl chloride. Permeation studies through rat skin were conducted on both types of patches using Teflon cells. The mean +/- SD flux values from the matrix- and reservoir-type patches were 99.55 +/- 22.89 and 31.82 +/- 8.31 micrograms/cm2.hr, respectively.
authors.affiliation: Drug Metabolism Laboratory, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, India.
authors.forename: G S
authors.initials: GS
authors.lastname: Arra
authors.forename: S
authors.initials: S
authors.lastname: Arutla
authors.forename: D R
authors.initials: DR
authors.lastname: Krishna
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D002626:Chemistry, Pharmaceutical; D004058:Diffusion; D016503:Drug Delivery Systems; D006801:Humans; D066298:In Vitro Techniques; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics; D008567:Membranes, Artificial; D010539:Permeability; D051381:Rats; D012867:Skin / Q000378:metabolism; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D008567:Membranes, Artificial; D014665:Vasodilator Agents; D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate