X-ray structural characterization of SR 142948, a novel potent synthetic neurotensin receptor antagonist.
SR 142948 is an original and extremely potent neurotensin receptor antagonist developed in a promising approach to novel antipsychotic drugs. The X-ray structure was elucidated and compared to SR 48692 and levocabastine, providing new informations about the possible recognition process of NT receptor subtypes.
Quéré
L
L
Laboratoire de Chimie Moléculaire Structurale, Facultés Universitaires Notre-Dame de la Paix, Namur, Belgium. Luc.Quere@UCB-Group.com
Longfils
G
G
Boigegrain
R
R
Labeeuw
B
B
Gully
D
D
Durant
F
F
D000818:Animals; D018360:Crystallography, X-Ray; D051379:Mice; D008958:Models, Molecular; D010880:Piperidines / Q000737:chemistry; D011487:Protein Conformation; D011720:Pyrazoles / Q000737:chemistry* / Q000494:pharmacology; D011804:Quinolines / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D018028:Receptors, Neurotensin / Q000037:antagonists & inhibitors*
D010880:Piperidines; D011720:Pyrazoles; D011804:Quinolines; D018028:Receptors, Neurotensin; C114947:SR 142948; C047340:levocabastine