Rate of neuronal fallout in a transsynaptic cerebellar model.
Quantitative analyses of transsynaptic granule cell death subsequent to the genetically determined degeneration of Purkinje cells in the cerebellum of pcd/pcd mutant mice show that granule neuron fallout follows a typical mathematical pattern of elemental decay. Biological and theoretical connotations are discussed in light of the empirical observations and a simulation model.
Triarhou
L C
LC
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis 46202-5120, USA.
D000818:Animals; D002452:Cell Count; D016923:Cell Death / Q000502:physiology; D002531:Cerebellum / Q000502:physiology*; D051379:Mice; D008818:Mice, Neurologic Mutants / Q000235:genetics; D008959:Models, Neurological; D009410:Nerve Degeneration / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D009474:Neurons / Q000502:physiology* / Q000648:ultrastructure; D011689:Purkinje Cells / Q000502:physiology; D013569:Synapses / Q000502:physiology*