title: Familial Crohn's disease with systemic lupus erythematosus.
abstract: We describe a young Japanese woman who was diagnosed with Crohn's disease affecting the ileum, transverse colon, and rectum, as confirmed by barium studies, colonoscopy, and histopathological examination. Her father and sister also had Crohn's disease. After a 4-yr course of sulfasalazine and elemental diet therapy, she was readmitted for perianal abscess associated with the presence of pancytopenia, microhematuria with granular cast, hypocomplementemia, and high titers of autoimmune antibodies (anti-ANA and anti-dsDNA antibodies). Based on these features, a diagnosis of systemic lupus erythematosus (SLE) was made. Despite the rarity of such combination (Crohn's disease with SLE), patients with Crohn's disease who develop such clinical findings might need evaluation for SLE.
authors.affiliation: The Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nishida
authors.forename: K
authors.initials: K
authors.lastname: Murase
authors.forename: R
authors.initials: R
authors.lastname: Ashida
authors.forename: O
authors.initials: O
authors.lastname: Sasaki
authors.forename: Y
authors.initials: Y
authors.lastname: Ozono
authors.forename: Y
authors.initials: Y
authors.lastname: Mizuta
authors.forename: F
authors.initials: F
authors.lastname: Takeshima
authors.forename: K
authors.initials: K
authors.lastname: Makiyama
authors.forename: S
authors.initials: S
authors.lastname: Kohno
mesh_terms: D000328:Adult; D003424:Crohn Disease / Q000150:complications* / Q000235:genetics*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D010375:Pedigree