title: Discovery of FR115092: a novel antinephritic agent.
abstract: A series of dapsone-related 4-aminopheynl and 2-aminothiazolyl derivatives was prepared, and their antinephritic activity and blood toxicity were evaluated. 5-(2-Pyridylsulfonyl)-2-thiazolamine (FR115092, 26) was effective against two nephritis models, namely graft-versus-host disease (GVHD) and autoimmune W/BF1 mice, and showed none of the blood toxicity observed with dapsone.
authors.affiliation: Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ogino
authors.forename: K
authors.initials: K
authors.lastname: Tsuji
authors.forename: T
authors.initials: T
authors.lastname: Tojo
authors.forename: N
authors.initials: N
authors.lastname: Igari
authors.forename: N
authors.initials: N
authors.lastname: Seki
authors.forename: Y
authors.initials: Y
authors.lastname: Sudo
authors.forename: T
authors.initials: T
authors.lastname: Manda
authors.forename: F
authors.initials: F
authors.lastname: Nishigaki
authors.forename: M
authors.initials: M
authors.lastname: Matsuo
mesh_terms: D000740:Anemia / Q000139:chemically induced; D000818:Animals; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D009393:Nephritis / Q000188:drug therapy*; D011725:Pyridines / Q000737:chemistry / Q000627:therapeutic use* / Q000633:toxicity; D013844:Thiazoles / Q000737:chemistry / Q000627:therapeutic use* / Q000633:toxicity
chemical_list: C116439:5-(2-pyridylsulfonyl)-2-thiazolamine; D011725:Pyridines; D013844:Thiazoles