The synthesis of a new type of anthracene DNA intercalator.
A new type of DNA intercalator based on anthracene 3 was synthesized. Preliminary binding studies show high affinity of this probe to CT-DNA. Higher binding constant of this compound (4.0 x 10(4) M-1) as compared with that known for 9-aminomethylanthracene, is caused presumably by enhanced electrostatic interaction.
Ostaszewski
R
R
Institute of Organic Chemistry, Polish Academy of Sciences, Warszawa. RYSZA@ICHF.EDU.PL
Wilczyńska
E
E
Wolszczak
M
M
D004247:DNA / Q000378:metabolism; D007364:Intercalating Agents / Q000138:chemical synthesis* / Q000378:metabolism
D007364:Intercalating Agents; D004247:DNA