[Investigation on in vivo metabolism of n-butyl phthalide].
A GC-MS method for the investigation on the metabolism of n-butyl phthalide (NBP) is described. After oral administration of NBP to rats, urine was collected, hydrolyzed with beta-glucuronidase, extracted and concentrated for TMS derivatization, and then analyzed by GC-MS. HBP and its four oxidative metabolites were determined in 0-24 h, 24-48 h rat urine. The mass spectra of the metabolites and their derivatives were presented and the in vivo metabolic pathway was discussed.
Peng
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SH
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
Zhou
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TH
D000818:Animals; D001572:Benzofurans / Q000378:metabolism*; D008401:Gas Chromatography-Mass Spectrometry; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D001572:Benzofurans; C027125:3-n-butylphthalide