title: ProClass Protein Family Database.
abstract: ProClass is a protein family database that organizes non-redundant sequence entries into families defined collectively by PROSITE patterns and PIR superfamilies. By combining global similarities and functional motifs into a single classification scheme, ProClass helps to reveal domain and family relationships and classify multi-domain proteins. The database currently consists of more than 120 000 sequence entries, approximately 60% of which is classified into about 3500 families. To maximize family information retrieval, the database provides links to various protein family/domain and structural class databases and contains multiple motif alignments of all PROSITE patterns as well as global alignments of PIR superfamilies. The motif sequences are retrieved from both PIR-International and SWISS-PROT databases, including a large number of new members detected by our GeneFIND family identification system. ProClass can be used to support full-scale genomic annotation, because of its high classification rate. The ProClass database is available for on-line search and record retrieval from our WWW server at http://diana.uthct.edu/proclass.html
authors.affiliation: Department of Epidemiology/Biomathematics, University of Texas Health Center at Tyler, Tyler, TX 75710, USA. wu@uthct.edu
authors.forename: C H
authors.initials: CH
authors.lastname: Wu
authors.forename: S
authors.initials: S
authors.lastname: Shivakumar
authors.forename: H
authors.initials: H
authors.lastname: Huang
mesh_terms: D000595:Amino Acid Sequence; D016208:Databases, Factual; D016678:Genome; D016247:Information Storage and Retrieval; D020407:Internet; D005810:Multigene Family; D011506:Proteins / Q000737:chemistry* / Q000145:classification / Q000235:genetics / Q000502:physiology*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D012984:Software
chemical_list: D011506:Proteins