Role of the telomeric DNA-binding protein TRF2 in the stability of human chromosome ends.
A major issue in telomere research is to understand how the integrity of chromosome ends is preserved. A recent study shows that expression of a dominant-negative form of the human telomeric protein TRF2 increases the number of chromosome fusions in immortalized cells and decreases the quantity of G-rich telomeric DNA 3' overhang, the G tail. Consequently, TRF2 appears to control the structure of the very end of the chromosomal DNA molecule and to prevent recombination between two telomeres. Remarkably, the same study reveals a potential role of TRF2 in cell division control.
Ancelin
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K
Laboratoire de Biologie Moléculaire et Cellulaire, Ecole Normale Supérieure de Lyon, UMR49 CNRS/ENS, France.
Brun
C
C
Gilson
E
E
D002455:Cell Division; D002877:Chromosomes, Human / Q000235:genetics* / Q000648:ultrastructure; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D016615:Telomere / Q000235:genetics* / Q000648:ultrastructure; D035341:Telomeric Repeat Binding Protein 2
D004268:DNA-Binding Proteins; D035341:Telomeric Repeat Binding Protein 2