title: A potent anti-diabetic agent from Kalopanax pictus.
abstract: To search for the anti-diabetic principle from the stem bark of Kalopanax pictus, seven kinds of chemical constituents including hedearagenin glycosides and phenolic glycosides were isolated. The anti-diabetic evaluation of these isolates in the streptozotocin-induced diabetic rats exhibited that kalopanaxsaponin A has a potent anti-diabetic activity in contrast to a mild activity of hedearagenin. In addition, significant hypocholesterolemic and hypolipidemic activities of kalopanaxsaponin A and hedearagenin were observed. The structure-activity relationship of kalopanaxsaponin A was also investigated in the present work.
authors.affiliation: Department of Botanical Resources, Sangji University, Wonju, Seoul.
authors.forename: H J
authors.initials: HJ
authors.lastname: Park
authors.forename: D H
authors.initials: DH
authors.lastname: Kim
authors.forename: J W
authors.initials: JW
authors.lastname: Choi
authors.forename: J H
authors.initials: JH
authors.lastname: Park
authors.forename: Y N
authors.initials: YN
authors.lastname: Han
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D008074:Lipoproteins / Q000097:blood; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D019441:Plant Epidermis / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D007004:Hypoglycemic Agents; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol