Early onset of nephrotic syndrome after treatment with D-penicillamine in a patient with Wilson's disease.
Wilson's disease responds to a variety of treatments including D-penicillamine and trientene. Nephrotic syndrome is a late complication of D-penicillamine treatment. We report a pediatric patient with Wilson's disease who developed nephrotic syndrome 2 wk after beginning D-penicillamine. His nephrosis resolved and his disease is quiescent with trientene treatment.
Siafakas
C G
CG
The Combined Program in Pediatric Gastroenterology and Nutrition, The Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Jonas
M M
MM
Alexander
S
S
Herrin
J
J
Furuta
G T
GT
D002614:Chelating Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D006527:Hepatolenticular Degeneration / Q000188:drug therapy*; D006801:Humans; D008297:Male; D009404:Nephrotic Syndrome / Q000139:chemically induced*; D010396:Penicillamine / Q000009:adverse effects* / Q000627:therapeutic use; D019233:Retreatment; D013997:Time Factors; D014266:Trientine / Q000627:therapeutic use
D002614:Chelating Agents; D010396:Penicillamine; D014266:Trientine