title: Syphilis in pregnant women and their children in the United Kingdom: results from national clinician reporting surveys 1994-7.
abstract: OBJECTIVE
  To measure the incidence of syphilis detected in pregnancy and congenital syphilis in the United Kingdom.
  
  
  METHODS
  Surveys through consultants in genitourinary medicine and paediatricians with active surveillance.
  
  
  METHODS
  United Kingdom, 1994-7.
  
  
  METHODS
  Women treated for syphilis in pregnancy, and children with early congenital syphilis born in the United Kingdom.
  
  
  RESULTS
  Over 3 years 139 women were diagnosed with and treated for syphilis in pregnancy; 121 were detected through antenatal screening. Thirty one had confirmed or probable congenitally transmissible syphilis, putting their pregnancies at risk. These were minimum figures but are compatible with the 90 to 100 women newly diagnosed annually as having infectious or early latent syphilis. A universal screening policy would require 18 600 and 55 700 women (maximum numbers) to be screened, respectively, to detect one woman needing treatment and to prevent one case of congenital syphilis. Nine presumptive cases of children with congenital syphilis born in the United Kingdom were reported. Mothers requiring treatment for syphilis were found in almost every health region but were more prevalent in London and the south east. Being born abroad and belonging to an ethnic minority group were strong risk factors, but 14% (19 of 121) of cases treated and six of 31 definite or probably transmissible cases occurred in white women born in the United Kingdom.
  
  
  CONCLUSIONS
  Congenitally transmissible syphilis continues to occur among pregnant women in the United Kingdom. Cases would be missed and stillbirths and congenitally infected babies would occur if antenatal screening was abandoned.
authors.affiliation: STD Section, HIV and STD Division, Public Health Laboratory Service Communicable Disease Surveillance Centre, London NW9 5EQ.
authors.forename: A K
authors.initials: AK
authors.lastname: Hurtig
authors.forename: A
authors.initials: A
authors.lastname: Nicoll
authors.forename: C
authors.initials: C
authors.lastname: Carne
authors.forename: T
authors.initials: T
authors.lastname: Lissauer
authors.forename: N
authors.initials: N
authors.lastname: Connor
authors.forename: J P
authors.initials: JP
authors.lastname: Webster
authors.forename: L
authors.initials: L
authors.lastname: Ratcliffe
mesh_terms: D004641:Emigration and Immigration; D005006:Ethnicity; D005260:Female; D006306:Health Surveys; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D008403:Mass Screening / Q000706:statistics & numerical data; D011159:Population Surveillance; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000453:epidemiology*; D011296:Prenatal Diagnosis / Q000706:statistics & numerical data*; D013587:Syphilis / Q000175:diagnosis / Q000453:epidemiology*; D013590:Syphilis, Congenital / Q000175:diagnosis / Q000453:epidemiology; D006113:United Kingdom / Q000453:epidemiology