Syntheses of 2-[(3,5-dimethyl-4-methoxypyridyl)alkyl]-benzothiazolidine derivatives as a potential gastric H+/K(+)-ATPase inhibitor.
A series of 2-[(3,5-dimethyl-4-methoxypyridyl)alkyl]benzothiazolidine derivatives were synthesized and tested their inhibitory effects on gastric H+/K(+)-ATPase. Compound 4d exhibited potent in vitro inhibitory activity.
Yoon
S H
SH
Department of Applied Chemistry, Ajou University, Suwon, Korea.
Seo
S
S
Lee
Y
Y
Hwang
S
S
Kim
D Y
DY
D000818:Animals; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D066298:In Vitro Techniques; D054328:Proton Pump Inhibitors; D051381:Rats; D013270:Stomach / Q000201:enzymology*; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D054328:Proton Pump Inhibitors; D013844:Thiazoles