title: Cyclin E overexpression in human gallbladder carcinomas.
abstract: The expression of cyclin E, one of the important positive cell cycle regulators, was examined immunohistochemically in gallbladder carcinomas. Cyclin E gene product was detected in 58 (49%) out of 118 cases. The degree of cyclin E expression was not associated with any clinicopathological factor including histology, the depth of tumor invasion, tumor stage and patient prognosis. Cyclin E expression was not correlated with that of p53 protein statistically, whereas it was correlated with the proliferative activity of the tumor cells by PCNA (p<0.05). These results suggested that cyclin E expression may confer progression of gallbladder carcinomas.
authors.affiliation: First Department of Internal Medicine, Hiroshima University School of Medicine, Minami-ku, Hiroshima 734-8551, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Eguchi
authors.forename: K
authors.initials: K
authors.lastname: Fujii
authors.forename: A
authors.initials: A
authors.lastname: Tsuchida
authors.forename: S
authors.initials: S
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Sasaki
authors.forename: G
authors.initials: G
authors.lastname: Kajiyama
mesh_terms: D015415:Biomarkers; D015153:Blotting, Western; D002277:Carcinoma / Q000737:chemistry* / Q000473:pathology; D002453:Cell Cycle; D002455:Cell Division; D019927:Cyclin E / Q000032:analysis*; D018450:Disease Progression; D005706:Gallbladder Neoplasms / Q000737:chemistry* / Q000473:pathology; D006801:Humans; D009363:Neoplasm Proteins / Q000032:analysis*; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis
chemical_list: D015415:Biomarkers; D019927:Cyclin E; D009363:Neoplasm Proteins; D018809:Proliferating Cell Nuclear Antigen