title: Pyrazoles, 1,2,4-triazoles, and tetrazoles as surrogates for cis-amide bonds in boronate ester thrombin inhibitors.
abstract: Substituted pyrazoles, 1,2,4-triazoles, and tetrazoles are good surrogates for cis-amide bonds in a series of boronate ester thrombin inhibitors.
authors.affiliation: DuPont Merck Pharmaceutical Company, Wilmington, DE 19880-0500, USA.
authors.forename: J V
authors.initials: JV
authors.lastname: Duncia
authors.forename: J B
authors.initials: JB
authors.lastname: Santella
authors.forename: C A
authors.initials: CA
authors.lastname: Higley
authors.forename: M K
authors.initials: MK
authors.lastname: VanAtten
authors.forename: P C
authors.initials: PC
authors.lastname: Weber
authors.forename: R S
authors.initials: RS
authors.lastname: Alexander
authors.forename: C A
authors.initials: CA
authors.lastname: Kettner
authors.forename: J R
authors.initials: JR
authors.lastname: Pruitt
authors.forename: A Y
authors.initials: AY
authors.lastname: Liauw
authors.forename: M L
authors.initials: ML
authors.lastname: Quan
authors.forename: R M
authors.initials: RM
authors.lastname: Knabb
authors.forename: R R
authors.initials: RR
authors.lastname: Wexler
mesh_terms: D000577:Amides / Q000737:chemistry / Q000494:pharmacology*; D001665:Binding Sites; D001897:Boronic Acids / Q000737:chemistry / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D007202:Indicators and Reagents; D008958:Models, Molecular; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013777:Tetrazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013917:Thrombin / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000577:Amides; D001897:Boronic Acids; D007202:Indicators and Reagents; D011720:Pyrazoles; D013777:Tetrazoles; D014230:Triazoles; D013917:Thrombin