Novel cytokine release inhibitors. Part II: Steroids.
Steroidal derivatives as IL-1 beta release inhibitors are discussed.
He
W
W
Department of Medicinal Chemistry, Rhône-Poulenc Rorer Central Research, Collegeville, PA 19426, USA.
Huang
F C
FC
Morytko
M
M
Jariwala
N
N
Yu
K T
KT
D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology; D002478:Cells, Cultured; D006801:Humans; D020128:Inhibitory Concentration 50; D007375:Interleukin-1 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism; D013256:Steroids / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000893:Anti-Inflammatory Agents; D007375:Interleukin-1; D013256:Steroids