title: Role of the telomeric DNA-binding protein TRF2 in the stability of human chromosome ends.
abstract: A major issue in telomere research is to understand how the integrity of chromosome ends is preserved. A recent study shows that expression of a dominant-negative form of the human telomeric protein TRF2 increases the number of chromosome fusions in immortalized cells and decreases the quantity of G-rich telomeric DNA 3' overhang, the G tail. Consequently, TRF2 appears to control the structure of the very end of the chromosomal DNA molecule and to prevent recombination between two telomeres. Remarkably, the same study reveals a potential role of TRF2 in cell division control.
authors.affiliation: Laboratoire de Biologie Moléculaire et Cellulaire, Ecole Normale Supérieure de Lyon, UMR49 CNRS/ENS, France.
authors.forename: K
authors.initials: K
authors.lastname: Ancelin
authors.forename: C
authors.initials: C
authors.lastname: Brun
authors.forename: E
authors.initials: E
authors.lastname: Gilson
mesh_terms: D002455:Cell Division; D002877:Chromosomes, Human / Q000235:genetics* / Q000648:ultrastructure; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D016615:Telomere / Q000235:genetics* / Q000648:ultrastructure; D035341:Telomeric Repeat Binding Protein 2
chemical_list: D004268:DNA-Binding Proteins; D035341:Telomeric Repeat Binding Protein 2