title: Facile and improved synthesis of 4 beta-aminopodophyllotoxin congeners.
abstract: An efficient synthesis of 4 beta-aminopodophyllotoxin from 4 beta-bromopodophyllotoxin using ammonia, and also a facile synthesis of 4 beta-amino-4'-O-demethylpodophyllotoxin from 4 beta-azidopodophyllotoxin by simultaneous azido reduction and selective demethylation at 4'-position employing chlorotrimethylsilane and sodium iodide, has been described. These are potential precursors for the various 4 beta-amino analogs of podophyllotoxin possessing DNA topoisomerase II inhibition activity.
authors.affiliation: Indian Institute of Chemical Technology, Hyderabad, India.
authors.forename: A
authors.initials: A
authors.lastname: Kamal
authors.forename: N L
authors.initials: NL
authors.lastname: Gayatri
authors.forename: N V
authors.initials: NV
authors.lastname: Rao
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis*; D011034:Podophyllotoxin / Q000138:chemical synthesis*; D059005:Topoisomerase II Inhibitors
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D059005:Topoisomerase II Inhibitors; D011034:Podophyllotoxin