Synthesis and antiviral activity of novel isodideoxy nucleosides with exocyclic methylene.
Novel isodideoxy nucleosides with exocyclic methylene were synthesized starting from L-xylose utilizing anomeric demethoxylation, Wittig reaction and Mitsunobu reaction as key steps and evaluated for antiviral activity.
Jeong
L S
LS
Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University, Seoul, Korea.
Yoo
S J
SJ
D000212:Acyclovir / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D003587:Cytomegalovirus / Q000187:drug effects; D015224:Dideoxynucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D015774:Ganciclovir / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects; D018259:Herpesvirus 1, Human / Q000187:drug effects; D018258:Herpesvirus 2, Human / Q000187:drug effects; D006801:Humans; D006838:Hydrocarbons; D007202:Indicators and Reagents; D008697:Methane / Q000031:analogs & derivatives*; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D014994:Xylose; D015215:Zidovudine / Q000494:pharmacology
D000998:Antiviral Agents; D015224:Dideoxynucleosides; D006838:Hydrocarbons; D007202:Indicators and Reagents; C030011:carbene; D015215:Zidovudine; D014994:Xylose; D008697:Methane; D015774:Ganciclovir; D000212:Acyclovir