[GABA reuptake by rat brain slices in hypokinesia and under the influence of cinnarizine and flunarizine].
Studies showed that 15-day restriction of motor activity inhibits the reuptake of GABA by sections of the rat brain cortex and hypothalamus. In prolonged intraperitoneal injection of 10 mg/kg cinnarizine in hyperkinesia, further inhibition of this process in hypothalamic sections is encountered on the 15th days. Flunarizin (1 mg/kg) administered in a like manner has no significant effect on GABA reuptake. A course of GABA injections in a dose of 5 mg/kg improves in rats with restricted motor activity the local blood flow in the frontal lobe of the brain.
Mirzoian
N R
NR
Department of Pharmacology, Erevan State Medical University, Yerevan, Armenia.
Akopian
V P
VP
Kocharian
A Zh
AZh
Knarian
V A
VA
Arakelian
L N
LN
Gevorkian
G A
GA
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002250:Carbon Radioisotopes; D002560:Cerebrovascular Circulation / Q000187:drug effects; D002936:Cinnarizine / Q000494:pharmacology*; D005444:Flunarizine / Q000494:pharmacology*; D018476:Hypokinesia / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D051381:Rats; D012149:Restraint, Physical; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000187:drug effects* / Q000378:metabolism* / Q000494:pharmacology
D002121:Calcium Channel Blockers; D002250:Carbon Radioisotopes; D002936:Cinnarizine; D005680:gamma-Aminobutyric Acid; D005444:Flunarizine
Obratnyĭ zakhvat GAMK srezami golovnogo mozga krys v usloviiakh gipokinezii i pod vliianiem tsinnarizina i flunarizina.