Insulin-like growth factor system in serum and cerebrospinal fluid in patients with multiple sclerosis.
The insulin-like growth factor (IGF) system influences oligodendrocyte survival, myelination, and immune functions. We examined whether alterations in the circulating IGF system occur in multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the central nervous system. We measured concentrations of IGF-I, IGF-II, and insulin-like growth factor binding proteins -1, -2, and -3 in both serum and cerebrospinal fluid from MS patients and age- and sex-matched controls. IGFBP-1 was not detectable in cerebrospinal fluid. We found no significant differences in any of the other components between patients with MS and controls.
Wilczak
N
N
Department of Neurology, Academisch Ziekenhuis Groningen, The Netherlands.
Schaaf
M
M
Bredewold
R
R
Streefland
C
C
Teelken
A
A
De Keyser
J
J
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000097:blood* / Q000134:cerebrospinal fluid*; D013002:Somatomedins / Q000134:cerebrospinal fluid* / Q000378:metabolism*
D013002:Somatomedins