Alternative solvent-free preparation methods for felodipine surface solid dispersions.
Surface solid dispersions were prepared via physical mixture and were either heated in a vacuum dryer or in a microwave oven for different periods of time. The physical state of felodipine in solid dispersions was studied using differential scanning calorimetry and x-ray powder diffractometry. USP paddle method was used for felodipine dissolution studies. The use of vacuum or microwave energy led to a significant improvement of felodipine dissolution which was caused partly by the amorphous state of felodipine and a large surface area of amorphous silicon dioxide.
Kerc
J
J
Lek Pharmaceutical and Chemical Company d.d., Research and Development Division, Ljubljana, Slovenia.
Srcic
S
S
Kofler
B
B
D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000737:chemistry / Q000302:isolation & purification*; D002152:Calorimetry, Differential Scanning; D004339:Drug Compounding / Q000379:methods; D015736:Felodipine / Q000008:administration & dosage / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans; D010316:Particle Size; D012995:Solubility; D012997:Solvents; D013499:Surface Properties; D014961:X-Ray Diffraction
D002121:Calcium Channel Blockers; D012997:Solvents; D015736:Felodipine