title: Novel protein kinase C inhibitors: alpha-terthiophene derivatives.
abstract: A series of alpha-terthiophene derivatives were prepared and their protein kinase C inhibitory activity were evaluated. The aldehyde derivatives were most potent inhibitors (IC50 < 1 microM). alpha-Terthiophene monoaldehyde was inactive in the inhibitions of protein kinase A, mitogen activated protein kinase and protein tyrosine kinase.
authors.affiliation: Department of Medicinal Chemistry, Purdue University, West Lafayette, IN 47907-1333, USA.
authors.forename: D S
authors.initials: DS
authors.lastname: Kim
authors.forename: C L
authors.initials: CL
authors.lastname: Ashendel
authors.forename: Q
authors.initials: Q
authors.lastname: Zhou
authors.forename: C T
authors.initials: CT
authors.lastname: Chang
authors.forename: E S
authors.initials: ES
authors.lastname: Lee
authors.forename: C J
authors.initials: CJ
authors.lastname: Chang
mesh_terms: D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D013876:Thiophenes; C019101:alpha-terthienyl; D011493:Protein Kinase C