The use of beta-cyclodextrin as a pelletization agent in the extrusion/spheronization process.
The use of beta-cyclodextrin for the preparation of pellets by the extrusion/spheronization process is described for different formulations and processing conditions. Sieve analysis and friability tests were performed to assess the physical and technological characteristics of pellets. Satisfactory products were obtained with beta-cyclodextrin contents up to 90% by weight.
Gazzaniga
A
A
Instituto Chimico Farmaceutico, Università di Milano, Italy. gazza@imiucca.csi.unimi.it
Sangalli
M E
ME
Bruni
G
G
Zema
L
L
Vecchio
C
C
Giordano
F
F
D003505:Cyclodextrins / Q000737:chemistry*; D004343:Drug Implants; D010316:Particle Size; D011312:Pressure; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D004343:Drug Implants; D047392:beta-Cyclodextrins; C031215:betadex