Syntheses of new modified Phe-Pro peptides. Use of proline replacements in potential HIV inhibitors.
The syntheses consisting of replacement of proline amino acid by a 3-pyrrolidinone ring in Phe-Pro analogues are described. Preliminary anti-HIV studies demonstrated the potential activity of this new class of compounds.
Bouygues
M
M
Laboratoire de Chimie Biomoléculaire, Faculté des Sciences de Luminy, Université de la Méditerranée, Marseille, France.
Medou
M
M
Quéléver
G
G
Chermann
J C
JC
Camplo
M
M
Kraus
J L
JL
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D004151:Dipeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D011392:Proline / Q000737:chemistry*; D013329:Structure-Activity Relationship
D019380:Anti-HIV Agents; D004151:Dipeptides; D011392:Proline