Garlic preparations for prevention of atherosclerosis.
On the basis of a number of new rigorously designed controlled studies, there is increasingly less evidence for lipid lowering properties of garlic preparations. Many other aspects of garlic drugs, such as direct effects on vessel walls (aortic elasticity, effects of antioxidant properties on early steps in atherosclerosis formation) or anti-platelet aggregation effects, are still awaiting further elucidation in clinical studies.
Berthold
H K
HK
Department of Clinical Pharmacology, University of Bonn, Germany. berthold@uni-bonn.de
Sudhop
T
T
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D001161:Arteriosclerosis / Q000517:prevention & control*; D002455:Cell Division / Q000187:drug effects; D002986:Clinical Trials as Topic; D005737:Garlic; D006801:Humans; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D010946:Plants, Medicinal; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology / Q000627:therapeutic use
D000975:Antioxidants; D008074:Lipoproteins; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors