Construction of a family of biphenyl combinatorial libraries: structure-activity studies utilizing libraries of mixtures.
A set of biphenyl aminoacid building blocks has been synthesized. These were used to construct partially-peptidic combinatorial libraries as equimolar multi-component samples. Activity of members of this library as vitronectin receptor antagonists is described, together with SAR studies of the most active members. These studies illustrate several important features of combinatorial libraries.
Neustadt
B R
BR
Schering-Plough Research Institute, Kenilworth, NJ 07033-0539, USA.
Smith
E M
EM
Lindo
N
N
Nechuta
T
T
Bronnenkant
A
A
Wu
A
A
Armstrong
L
L
Kumar
C
C
D001713:Biphenyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D019992:Databases as Topic; D015195:Drug Design; D007536:Isomerism; D007700:Kinetics; D008968:Molecular Conformation; D015394:Molecular Structure; D019030:Receptors, Vitronectin / Q000187:drug effects / Q000378:metabolism*; D013329:Structure-Activity Relationship
D001713:Biphenyl Compounds; D019030:Receptors, Vitronectin