[Transdermal route as an alternative to oral administration of opioids in cancer pain].
Fentanyl TTS, the only transdermal opioid, represents a real tool for a better quality of life in patients with cancer pain. In this paper we report a short description of the pharmacologic properties and administration procedures of this drug that is a useful alternative when other opioids recommended on the third step of the WHO analgesic ladder, are ineffective or present unbearable side effects (nausea and/or vomiting-severe mucosites and dysphagia). In particular we indicated some changes and adjustments switching from morphine per os to fentanyl TTS. In addition we report the results of a study carried out in our Pain Therapy Center on 49 patients with severe oncologic pain, previously treated with opioids and other drugs associations. Our results indicated a good control of continuous nociceptive cancer pain, with a better quality of life and lesser side effects to respect the previous regime of orally opioids.
Burza
M
M
Istituto Regina Elena, Servizio di Terapia del Dolore e Rianimazione, Roma, Italia.
Ginobbi
P
P
Fusco
G
G
Laurenzi
L
L
Tirelli
W
W
Arcuri
E
E
D000279:Administration, Cutaneous; D000284:Administration, Oral; D000701:Analgesics, Opioid / Q000008:administration & dosage*; D005283:Fentanyl / Q000008:administration & dosage*; D006801:Humans; D009020:Morphine / Q000008:administration & dosage*; D009369:Neoplasms / Q000188:drug therapy / Q000503:physiopathology*; D010148:Intractable Pain / Q000188:drug therapy*; D010166:Palliative Care
D000701:Analgesics, Opioid; D009020:Morphine; D005283:Fentanyl
La via transdermica come alternativa agli oppioidi per os nel dolore oncologico.