title: Synthesis and biological activity of novel thiazolidinediones.
abstract: Novel compounds having a dual pharmacophore were synthesised and evaluated for their insulin sensitiser and anti-inflammatory properties in different animal models.
authors.affiliation: Department of Process Research and Development, Dr. Reddy's Research Foundation, Miyapur, Hyderabad, India.
authors.forename: C
authors.initials: C
authors.lastname: Prabhakar
authors.forename: G
authors.initials: G
authors.lastname: Madhusudhan
authors.forename: K
authors.initials: K
authors.lastname: Sahadev
authors.forename: C M
authors.initials: CM
authors.lastname: Reddy
authors.forename: M R
authors.initials: MR
authors.lastname: Sarma
authors.forename: G O
authors.initials: GO
authors.lastname: Reddy
authors.forename: R
authors.initials: R
authors.lastname: Chakrabarti
authors.forename: C S
authors.initials: CS
authors.lastname: Rao
authors.forename: T D
authors.initials: TD
authors.lastname: Kumar
authors.forename: R
authors.initials: R
authors.lastname: Rajagopalan
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology*; D001786:Blood Glucose / Q000187:drug effects; D002074:Butanones / Q000494:pharmacology; D002839:Chromans / Q000494:pharmacology; D004487:Edema / Q000188:drug therapy; D005260:Female; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D008297:Male; D051379:Mice; D000077430:Nabumetone; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D045162:Thiazolidinediones; D000077288:Troglitazone
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001786:Blood Glucose; D002074:Butanones; D002839:Chromans; D007004:Hypoglycemic Agents; D013844:Thiazoles; D045162:Thiazolidinediones; D000077288:Troglitazone; D000077430:Nabumetone; C115174:netoglitazone