Isoindolinone enantiomers having affinity for the dopamine D4 receptor.
PD 108635 (1) was identified as a potent dopamine D4 ligand and we wanted to replace the benzylic alcohol with a metabolically more stable moiety. Investigations led to the discovery of a series of isoindolinones having D4 affinity.
Belliotti
T R
TR
Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Co., Ann Arbor, MI 48105, USA.
Brink
W A
WA
Kesten
S R
SR
Rubin
J R
JR
Wustrow
D J
DJ
Zoski
K T
KT
Whetzel
S Z
SZ
Corbin
A E
AE
Pugsley
T A
TA
Heffner
T G
TG
Wise
L D
LD
D000818:Animals; D007211:Indoles / Q000737:chemistry* / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017448:Receptors, Dopamine D2 / Q000187:drug effects*; D050638:Receptors, Dopamine D4; D011985:Receptors, Serotonin / Q000378:metabolism; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014961:X-Ray Diffraction
C493601:Drd4 protein, rat; D007211:Indoles; D017448:Receptors, Dopamine D2; D011985:Receptors, Serotonin; D050638:Receptors, Dopamine D4