The conditional binomial test revisited for clinical trials.
McNemar's test is used to test the hypothesis that one treatment is better than another in a matched-pair design for binary outcomes. The conditional binomial test in such a matched-pair design is the exact McNemar test. However, in many clinical trials, one wants to establish equivalency between two treatments. We discuss how to use a conditional binomial test to establish equivalency between two treatments in a matched-pair design. Sample size and power determination for each conditional binomial test are calculated. Some statistical properties of the tests are analyzed through Monte Carlo simulation.
Lei
X
X
NeoPath, Inc., Redmond, Washington 98052, USA.
Davis
D
D
Kuan
L
L
Lee
J
J
Oh
S
S
D016010:Binomial Distribution; D002986:Clinical Trials as Topic / Q000379:methods*; D006801:Humans; D009010:Monte Carlo Method; D013810:Therapeutic Equivalency