Tyrosine kinase activity is associated with CD44 in human neutrophils.
CD44 appears to be involved in signal transduction, however, the mechanism of this function is unclear. Protein kinase activity was detected in neutrophils associated with CD44. Most of the protein kinase activity associated with these antigens was tyrosine kinase activity. Src family kinases lyn and hck were found to account for much of the associated tyrosine kinase activity. The data suggest that associated tyrosine kinase activity may play a role in signal transduction from CD44 in neutrophils to regulate other cell functions.
Skubitz
K M
KM
Department of Medicine, University of Minnesota Medical School, University Hospital, Minneapolis 55455, USA. skubi001@tc.umn.edu
Campbell
K D
KD
Skubitz
A P
AP
D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism*; D009504:Neutrophils / Q000201:enzymology* / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D051572:Proto-Oncogene Proteins c-hck; D015398:Signal Transduction / Q000502:physiology*; D019061:src-Family Kinases
D018960:Hyaluronan Receptors; D011518:Proto-Oncogene Proteins; D011494:Protein Kinases; D011505:Protein-Tyrosine Kinases; C496631:HCK protein, human; D051572:Proto-Oncogene Proteins c-hck; C060902:lyn protein-tyrosine kinase; D019061:src-Family Kinases