Shock syndrome induced by bromocriptine test in a patient with prolactinoma--case report.
A 72-year-old male developed shock syndrome after a single dose of bromocriptine. He had undergone uncomplicated subtotal removal of an invasive prolactinoma in our department. The patient had normal ranges of pituitary hormones apart from hyperprolactinemia (167.7 ng/ml) after surgery. An acute suppression test with bromocriptine (2.5 mg per os) was done in the supine position 6 days following surgery. Three and a half hours after bromocriptine administration, he suddenly complained of anterior chest discomfort in bed. Cyanosis and profuse diaphoresis were noted. His blood pressure was 80/60 mmHg. Electrocardiography revealed sporadic premature contractions and slight depression in the ST segments. He recovered in about 10 hours after a rapid infusion of corticosteroid and lactic Ringer solution, and was discharged without sequelae. This is a very rare complication of bromocriptine, but the cardiovascular function of patients taking bromocriptine for therapeutic and diagnostic purpose should be monitored carefully.
Nakasu
Y
Y
Department of Neurosurgery, Shiga University of Medical Science, Ohtsu.
Shiino
A
A
Nakasu
S
S
Handa
J
J
D000368:Aged; D001971:Bromocriptine / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D010911:Pituitary Neoplasms / Q000188:drug therapy* / Q000601:surgery; D015175:Prolactinoma / Q000188:drug therapy* / Q000601:surgery; D012769:Shock / Q000139:chemically induced*; D013577:Syndrome; D014665:Vasodilator Agents / Q000009:adverse effects* / Q000627:therapeutic use
D014665:Vasodilator Agents; D001971:Bromocriptine