Oligonucleotides bearing 5-formyl-2'-O-methyluridine: preference in binding affinity to the NF-kappa B (p50)2 homo- and p50/p65 heterodimers.
5-Formyl-2'-O-methyluridine was incorporated into the various positions of oligonucleotide 26-mers containing the NF-kappa B binding sequence. Some of them showed binding selectivity toward the homo- and heterodimers of subunits of NF-kappa B.
Kittaka
A
A
School of Pharmaceutical Sciences, Showa University, Tokyo, Japan.
Kuze
T
T
Asakura
T
T
Ito
K
K
Miyasaka
T
T
Inoue
J
J
D004247:DNA / Q000378:metabolism; D019281:Dimerization; D016328:NF-kappa B / Q000378:metabolism*; D009841:Oligonucleotides / Q000378:metabolism*; D014529:Uridine / Q000031:analogs & derivatives* / Q000378:metabolism
C116648:5-formyl-2'-O-methyluridine; D016328:NF-kappa B; D009841:Oligonucleotides; D004247:DNA; D014529:Uridine