An approach to switching patients from baclofen to tizanidine.
With the introduction of the antispasticity agent, tizanidine hydrochloride (Zanaflex), physicians have requested information about the optimal way to switch appropriate patients from baclofen to tizanidine. A group of neurologists and rehabilitation specialists with a particular interest in spasticity was therefore asked to draw up a suitable approach to changing treatment.
Brenner
R
R
Department of Neurology, Royal Free Hospital, London.
Hyman
N
N
Knobler
R
R
O'Brien
M
M
Stephan
T
T
D001418:Baclofen / Q000009:adverse effects / Q000627:therapeutic use*; D002983:Clinical Competence; D003000:Clonidine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D009103:Multiple Sclerosis / Q000150:complications; D009125:Muscle Relaxants, Central / Q000009:adverse effects / Q000627:therapeutic use*; D009128:Muscle Spasticity / Q000188:drug therapy* / Q000209:etiology; D013118:Spinal Cord Diseases / Q000188:drug therapy; D013119:Spinal Cord Injuries / Q000188:drug therapy
D009125:Muscle Relaxants, Central; C023754:tizanidine; D001418:Baclofen; D003000:Clonidine