[Isocitrate dehydrogenases of trematodes parasitizing cattle and the feasibility of inhibiting them using anthelmintic preparations].
Activities and properties of NADF-dependent isocitrate dehydrogenases in cytosol and mitochondrial fractions from trematodes Eurytrema pancreaticum and Calicophoron ijimai were examined. Cytosol and mitochondrial enzymes were activated by ions Mn2+ and Mg2+ and inhibited by ions of heavy metals and p-chloromercuribenzoate. The effect of anthelmintic preparations on activity of enzymes was investigated.
Burenina
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EA
D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000201:enzymology; D003600:Cytosol / Q000201:enzymology; D007521:Isocitrate Dehydrogenase / Q000302:isolation & purification*; D019216:Metals, Heavy / Q000627:therapeutic use; D008928:Mitochondria / Q000201:enzymology; D012417:Rumen / Q000469:parasitology; D014200:Trematoda / Q000201:enzymology*; D014201:Trematode Infections / Q000188:drug therapy / Q000201:enzymology / Q000662:veterinary*; D020245:p-Chloromercuribenzoic Acid / Q000627:therapeutic use
D000871:Anthelmintics; D019216:Metals, Heavy; D020245:p-Chloromercuribenzoic Acid; D007521:Isocitrate Dehydrogenase
Izotsitratdegidrogenazy trematod, parazitiruiushchikh u krupnogo rogatogo skota, i vozmozhnost' ingibirovaniia ikh nekotorymi antgel'mintnymi preparatami.