title: Mouse homolog of the yeast origin recognition complex subunit ORC1 and chromosomal localization of the cognate mouse gene Orc1.
abstract: ORC1 encodes a subunit of the eukaryotic origin recognition complex in yeast, which has been shown to play a crucial role in chromosomal DNA replication and transcriptional silencing. We have identified a mouse protein closely related to Saccharomyces cerevisiae ORC1 as well as to the human, Xenopus and Drosophila homologs. MmORC1 has putative cyclin-dependent phosphorylation sites and a nucleotide triphosphate-binding motif. We have mapped the gene locus of the murine Orc1 gene to chromosome 4, band D. Conservation of structures among members of the ORC1-related proteins suggests that these proteins play a key role in the intiation of DNA replication in all eukaryotes.
authors.affiliation: Institute of Biochemistry, Biozentrum, University of Würzburg, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Zisimopoulou
authors.forename: C
authors.initials: C
authors.lastname: Staib
authors.forename: I
authors.initials: I
authors.lastname: Nanda
authors.forename: M
authors.initials: M
authors.lastname: Schmid
authors.forename: F
authors.initials: F
authors.lastname: Grummt
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002874:Chromosome Mapping; D017124:Conserved Sequence; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D051738:Origin Recognition Complex; D017386:Sequence Homology, Amino Acid
chemical_list: D004268:DNA-Binding Proteins; C497228:Orc1 protein, mouse; D051738:Origin Recognition Complex