Bactericidal activity of catechin-copper (II) complexes on Escherichia coli ATCC11775 in the absence of hydrogen peroxide.
Washed Escherichia coli ATCC11775 cells were killed by (-)-epigallocatechin (EGC) in the presence of a non-lethal concentration of Cu2+ (1 mumol l-1) without additional H2O2, but not by (-)-epicatechin (EC). EGC alone (< 0.1 mmol l-1) did not reduce the viability of the cells. The survival curve obtained in the presence of EGC and Cu2+ was similar to that obtained in the presence of (-)-adrenaline (EN) and Cu2+.
Kimura
T
T
Department of Chemistry, Shiga University of Medical Science, Japan. kimura@sums.shiga-med.ac.jp
Hoshino
N
N
Yamaji
A
A
Hayakawa
F
F
Ando
T
T
D002392:Catechin / Q000494:pharmacology*; D003300:Copper / Q000494:pharmacology*; D004837:Epinephrine / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects*; D006861:Hydrogen Peroxide / Q000494:pharmacology
D003300:Copper; D002392:Catechin; D006861:Hydrogen Peroxide; D004837:Epinephrine