title: Prognostic factors in patients with with locally advanced cervical cancer treated with radical hysterectomy and adjuvant radiotherapy.
abstract: The purpose of this study was to investigate the presence of risk factors for node metastases and to estimate survival in patients with cervical cancer, stages IB and IIA. In a retrospective study of 103 patients with cervical cancer stages IB and IIA, all treated with radical hysterectomy and adjuvant radiotherapy, we estimated survival curves according to different prognostic parameters. Mean follow-up time was 97 months. A significant difference between clinical pre-operative assessment and histological determination of real extent of the disease was evidenced. Pelvic lymph node metastases (P = 0.0005) significantly correlated with survival. This study shows that only lymph node involvement is an independent prognostic factor. Stage acts through nodal status in its impact on survival. A surgical-pathological staging in early stage cervical cancers is found to be more appropriate to correctly estimate patients' survival and prognosis.
authors.affiliation: Department of Obstetrics and Gynecology, University of Milano School of Medicine, H San Raffaele Scientific Institute, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Frigerio
authors.forename: A
authors.initials: A
authors.lastname: Mariani
authors.forename: L
authors.initials: L
authors.lastname: Gandini
authors.forename: M
authors.initials: M
authors.lastname: Origoni
authors.forename: L
authors.initials: L
authors.lastname: Galli
authors.forename: E
authors.initials: E
authors.lastname: Rabaiotti
authors.forename: G
authors.initials: G
authors.lastname: Aletti
authors.forename: A
authors.initials: A
authors.lastname: Ferrari
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*