title: A paclitaxel analogue with a 2(3-->20)abeotaxane skeleton: synthesis and biological evaluation.
abstract: A paclitaxel analogue having an unusual tricyclic [9.3.1.1] hexadecane skeleton was synthesized from deaminoacyltaxine A, a 2(3-->20) abeotaxane isolated in considerable amounts from the leaves of Taxus baccata L. In preliminary studies, this compound showed a much lower cytotoxicity than paclitaxel.
authors.affiliation: Departamento de Química Orgánica, Facultade de Química, Universidade de Santiago de Compostela, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Soto
authors.forename: J L
authors.initials: JL
authors.lastname: Mascareñas
authors.forename: L
authors.initials: L
authors.lastname: Castedo
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D017239:Paclitaxel / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D017239:Paclitaxel