[Effect of bee venom and its components on electrophoretic mobility of erythrocytes].
The change of electrophoretic mobility (EPM) of erythrocytes of donor blood caused by their incubations with the bee venom and its major components--melittin and phospholipase A2 was investigated. It was estimated that the bee venom reversibly decreased EPM of erythrocytes to the higher degree than its separate components. The reaction was completely abolished after preliminary processing of erythrocytes with neuroaminidase and partly after their processing with glutaraldehyde, but the effect of EPM increased under the conditions of the increasing of ATP concentration. Proceeding from the authors' data it was concluded that the major components of the bee venom successively interacted with glicocalyx elements and membrane of erythrocytes which evokes the charge redistribution in these blood cells.
Krylov
V N
VN
N.I. Lobachevsky State University, Nizhniy Novgorod.
Deriugina
A V
AV
D000255:Adenosine Triphosphate / Q000494:pharmacology; D001514:Bee Venoms / Q000737:chemistry / Q000494:pharmacology*; D004586:Electrophoresis; D004912:Erythrocytes / Q000187:drug effects*; D005976:Glutaral / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008555:Melitten / Q000494:pharmacology; D010741:Phospholipases A / Q000494:pharmacology; D054467:Phospholipases A2
D001514:Bee Venoms; D008555:Melitten; D000255:Adenosine Triphosphate; D010741:Phospholipases A; D054467:Phospholipases A2; D005976:Glutaral
Vliianie pchelinogo iada i ego komponentov na élektroforeticheskuiu podvizhnost' éritrotsitov.