[Antiradical activity and membranotropic action of cardio- and vasotropic compounds of varying chemical nature].
Antiradical activity and ability to interaction with phosphatidylcholine bilayer of the physiological active compounds (PhAC), concerning the classes of phenylalkilamines (dobutamine, verapamil), dihydro pyridines (BAY-K-4688, nifedipine), analogues of crown ether (carbicyle, diol) was studied. By means of the method of microcalorimetry and spectrophotometry it was shown the complexing ability PhAC with the phospholipid bilayer of the model membrane. It was stated the simbasity in the changes of the thermal effect of the compounds with the negative inotropic activity during its reaction with phosphatidylcholine bilayer and antiradical activity. That show on the presence of antiradical component in the mechanism that compounds' action.
Nizhenkovskaia
I V
IV
National Medical University, Kyiv.
Gubskiĭ
Iu I
IuI
Checkman
I S
IS
Goriushko
A G
AG
Gorchakova
N A
NA
Sachenko
L G
LG
D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester / Q000737:chemistry / Q000494:pharmacology; D002118:Calcium / Q000493:pharmacokinetics; D002120:Calcium Channel Agonists / Q000737:chemistry / Q000494:pharmacology*; D002121:Calcium Channel Blockers / Q000737:chemistry / Q000494:pharmacology*; D002316:Cardiotonic Agents / Q000737:chemistry / Q000494:pharmacology*; D004280:Dobutamine / Q000737:chemistry / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology*; D017136:Ion Transport / Q000187:drug effects; D008051:Lipid Bilayers; D009206:Myocardium / Q000378:metabolism*; D009543:Nifedipine / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014665:Vasodilator Agents / Q000737:chemistry / Q000494:pharmacology*; D014700:Verapamil / Q000737:chemistry / Q000494:pharmacology
D002120:Calcium Channel Agonists; D002121:Calcium Channel Blockers; D002316:Cardiotonic Agents; D016166:Free Radical Scavengers; D008051:Lipid Bilayers; D014665:Vasodilator Agents; D004280:Dobutamine; D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; D014700:Verapamil; D009543:Nifedipine; D002118:Calcium
Antiradikal'naia aktivnost; i membranotropnoe deĭstvie kardio- i vazotropnykh soedineniĭ razlichnoĭ khimicheskoĭ prirody.