title: Neuronorm is a potent and water soluble neurokinin A receptor antagonist.
abstract: We report here the synthesis and preliminary pharmacological characterization of a novel water soluble Neurokinin A receptor antagonist named Neuronorm. The synthesis was achieved in high yield by a combination of classical peptide synthesis methodologies, in both solution and solid phase. The pharmacological properties as neurokinin A receptor antagonist were assessed in in vitro experiments on rat vas deferens and guinea pig trachea, and were compared to those of MEN10627.
authors.affiliation: Centro Interuniveristario di Ricerca su Peptidi Bioattivi, Università di Napoli Federico II, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Lombardi
authors.forename: B
authors.initials: B
authors.lastname: D'Agostino
authors.forename: A
authors.initials: A
authors.lastname: Filippelli
authors.forename: C
authors.initials: C
authors.lastname: Pedone
authors.forename: M G
authors.initials: MG
authors.lastname: Matera
authors.forename: M
authors.initials: M
authors.lastname: Falciani
authors.forename: M
authors.initials: M
authors.lastname: De Rosa
authors.forename: F
authors.initials: F
authors.lastname: Rossi
authors.forename: V
authors.initials: V
authors.lastname: Pavone
mesh_terms: D000818:Animals; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D018041:Receptors, Neurokinin-2 / Q000037:antagonists & inhibitors*; D014132:Trachea / Q000187:drug effects; D014649:Vas Deferens / Q000187:drug effects
chemical_list: D010456:Peptides, Cyclic; D018041:Receptors, Neurokinin-2; C116640:neuronorm; C090951:MEN 10627