title: Prevalence of factor V Leiden (APCR) and other inherited thrombophilias in young patients with myocardial infarction and normal coronary arteries.
abstract: OBJECTIVE
  To investigate the role of activated protein C resistance (APCR, factor V Leiden) in coronary artery thrombosis.
  
  
  METHODS
  The prevalence of APCR and of congenital deficiencies of antithrombin III, protein C, protein S, plasminogen, and factor XII was investigated in adult patients under 45 years of age with acute myocardial infarction. The results were compared with those of a group of 53 age and sex matched control subjects.
  
  
  RESULTS
  Among 75 patients under the age of 45 years who were admitted from November 1994 to April 1996 for acute myocardial infarction, 22 (29.3%) had normal coronary arteriography (group I) and 53 (70.7%) had significant coronary artery disease (group II). Inherited thrombophilia was more often found in group I (4/22, 18.2%) than in group II (4/53, 7.5%) but the difference was not significant (F test: p = 0.22). The prevalence of APCR was 9.1% (2/22) in group I, 3.8% (2/53) in group 2 (p = 0.57), and 3.8% (2/53) in the normal control group (p = 0.57).
  
  
  CONCLUSIONS
  The prevalence of congenital thrombophilias, including APCR, does not seem to be increased in young patients with myocardial infarction and normal coronary angiograms, compared with young patients with coronary atherosclerosis and with normal control subjects. However, the statistical power of the study is too low to detect a significant difference and these results are published to allow a meta-analysis of this problem in the future.
authors.affiliation: Department of Cardiology, North Hospital, Saint-Etienne, France.
authors.forename: A
authors.initials: A
authors.lastname: Dacosta
authors.forename: B
authors.initials: B
authors.lastname: Tardy-Poncet
authors.forename: K
authors.initials: K
authors.lastname: Isaaz
authors.forename: A
authors.initials: A
authors.lastname: Cerisier
authors.forename: P
authors.initials: P
authors.lastname: Mismetti
authors.forename: S
authors.initials: S
authors.lastname: Simitsidis
authors.forename: J
authors.initials: J
authors.lastname: Reynaud
authors.forename: B
authors.initials: B
authors.lastname: Tardy
authors.forename: M
authors.initials: M
authors.lastname: Piot
authors.forename: H
authors.initials: H
authors.lastname: Decousus
authors.forename: D
authors.initials: D
authors.lastname: Guyotat
mesh_terms: D020016:Activated Protein C Resistance / Q000097:blood / Q000150:complications*; D000328:Adult; D000990:Antithrombin III / Q000032:analysis; D016022:Case-Control Studies; D003327:Coronary Disease / Q000097:blood / Q000150:complications; D005165:Factor V / Q000032:analysis*; D005175:Factor XII Deficiency / Q000097:blood / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D017566:Microvascular Angina / Q000097:blood / Q000150:complications*; D009203:Myocardial Infarction / Q000097:blood; D010958:Plasminogen / Q000032:analysis; D015995:Prevalence; D011446:Prospective Studies; D011486:Protein C / Q000032:analysis; D019851:Thrombophilia / Q000097:blood / Q000150:complications
chemical_list: D011486:Protein C; C095381:factor V Leiden; D000990:Antithrombin III; D005165:Factor V; D010958:Plasminogen