title: Synthesis and anticancer evaluation of certain gamma-aryloxymethyl-alpha-methylene-gamma-phenyl-gamma-butyrolactones.
abstract: Certain gamma-aryloxymethyl-alpha-methylene-gamma-phenyl- gamma-butyrolactones were synthesized and evaluated for their anticancer activity. These compounds demonstrated a strong growth inhibitory activity against leukemia cell lines but are relatively inactive against non-small cell lung cancers and CNS cancers. The anticancer potency for aryl portion is in an order of quinoline > 8-hydroxyquinoline > 2-methylquinoline >> naphthalene >> benzene.
authors.affiliation: School of Chemistry, Kaohsiung Medical College, Taiwan, R.O.C.
authors.forename: T C
authors.initials: TC
authors.lastname: Wang
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
authors.forename: Y L
authors.initials: YL
authors.lastname: Chen
authors.forename: S S
authors.initials: SS
authors.lastname: Liou
authors.forename: C C
authors.initials: CC
authors.lastname: Tzeng
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D015107:4-Butyrolactone