title: Localized fibrous tumours of the pleura: 15 new cases and review of the literature.
abstract: OBJECTIVE
  To present a series of localized fibrous tumours of the pleura (LFTP), to define the clinical and histopathological diagnostic criteria of this tumour, and to determine the optimal treatment and follow-up.
  
  
  METHODS
  Review of the charts of the patients with the diagnosis of LFTP (formerly called benign fibrous mesothelioma), as well as of all the histological sections, including immunohistochemical stains. Review of the literature with special emphasis on the clinical and histological criteria of malignancy.
  
  
  RESULTS
  During the last 30 years, we found 15 patients with a complete clinical chart and histological material, particularly paraffin blocks of the tumour. The mean age was 57 years (range 27-79). Eight patients were asymptomatic, and the remaining seven presented with non-specific symptoms. All but one had complete resection of the tumour, including partial lung resection in two and partial chest wall resection in three. The diagnosis was confirmed by histological review in 15 cases. Immunohistochemical stainings showed positivity for vimentin in all cases, for CD 34 in 80%, but were consistently negative for cytokeratins. Nine tumours were histologically classified as malignant. Among them, five recurred, two of which were responsible for death. One benign tumour recurred after 1 year, and was treated successfully by repeat resection and radiotherapy. Overall, 13 patients (86%) were alive with no evidence of disease between 10 months and 27 years after the first resection.
  
  
  CONCLUSIONS
  LFTP is a rare tumour which has a benign clinical course in over 80% of the cases, and is asymptomatic in half the patients. The diagnosis is difficult to establish before operation. Treatment consists of complete resection including adjacent structures if necessary. The clinical behaviour of LFTP cannot be predicted on the basis of histological aspects only. If histologically malignant tumours are more prone to recurrence and poor outcome, broad-based and locally invasive tumours bear a higher risk of recurrence. Long term follow-up is therefore mandatory in all cases in order to perform early re-resection when recurrence occurs.
authors.affiliation: Department of Surgery, University Hospital (Centre Hospitalier Universitaire Vaudois), Lausanne, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Suter
authors.forename: S
authors.initials: S
authors.lastname: Gebhard
authors.forename: M
authors.initials: M
authors.lastname: Boumghar
authors.forename: N
authors.initials: N
authors.lastname: Peloponisios
authors.forename: C Y
authors.initials: CY
authors.lastname: Genton
mesh_terms: D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008654:Mesothelioma / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D010994:Pleura / Q000378:metabolism / Q000473:pathology; D010997:Pleural Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery; D015996:Survival Rate; D013557:Switzerland / Q000453:epidemiology