title: Solution and solid phase combinatorial synthesis of peptidomimetic library containing diversified alpha-methylated amino acids.
abstract: A combinatorial peptidomimetic library containing diversified alpha-methylated amino acids was generated by the Ugi four component condensation (4cc) reaction from acids, amines, isocyanides and ketones in both solution and solid phase synthetic procedures. This one-pot methodology overall gave fair to good yields, which compare well with multi-step syntheses.
authors.affiliation: Biotech Research Institute, LG Chemical Ltd./Research Park, Science Town, Taejon, Korea.
authors.forename: S W
authors.initials: SW
authors.lastname: Kim
authors.forename: Y S
authors.initials: YS
authors.lastname: Shin
authors.forename: S
authors.initials: S
authors.lastname: Ro
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D018716:Molecular Mimicry; D015394:Molecular Structure; D019151:Peptide Library; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D012996:Solutions
chemical_list: D000596:Amino Acids; D019151:Peptide Library; D010455:Peptides; D012996:Solutions