Peptides related to FKBP 39-45 loop possess immunostimulative potency.
Taking into account the sequential homology existing between thymopoietin II, the DNA-binding domain of p53 protein and FKBP (FK-506 binding protein), a series of fragments of human and bovine FKBP containing a fragment Ser39-Pro45 were synthesized. In the humoral in vitro test all the peptides act as stimulators. Whereas in the in vivo test peptides derived from bovine FKBP show an immunostimulative and those from human FKBP an immunosuppressive activity. However, after blocking the Asp residue by a Bzl group the peptide V appears to be an immunostimulator. The data obtained suggest that these peptides can influence the immune system by blocking the FKBP receptor.
Siemion
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IZ
Faculty of Chemistry, University of Wroclaw, Poland. SIEMION@WCHUWR.CHEM.UNI.WROC.PL
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Wieczorek
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D000276:Adjuvants, Immunologic; D000595:Amino Acid Sequence; D000818:Animals; D001681:Biological Assay; D002417:Cattle; D006801:Humans; D020104:Immunophilins / Q000276:immunology*; D007375:Interleukin-1 / Q000032:analysis; D007376:Interleukin-2 / Q000032:analysis; D015850:Interleukin-6 / Q000032:analysis; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000276:immunology; D022021:Tacrolimus Binding Proteins; D016305:Thymopentin / Q000276:immunology; D013946:Thymopoietins / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis; D016159:Tumor Suppressor Protein p53 / Q000276:immunology
D000276:Adjuvants, Immunologic; D007375:Interleukin-1; D007376:Interleukin-2; D015850:Interleukin-6; D009842:Oligopeptides; D013946:Thymopoietins; D014409:Tumor Necrosis Factor-alpha; D016159:Tumor Suppressor Protein p53; D022021:Tacrolimus Binding Proteins; D020104:Immunophilins; D016305:Thymopentin