title: Different influence of incongruent follicular development on in vitro fertilization-embryo transfer and gamete intrafallopian transfer pregnancy rates.
abstract: OBJECTIVE
  To compare the influence of incongruent (asymmetric) follicular development on treatment outcome in IVF-ET and GIFT cycles.
  
  
  METHODS
  A retrospective comparative study.
  
  
  METHODS
  Tertiary referral center for infertility.
  
  
  METHODS
  Five hundred forty-three consecutive assisted reproduction cycles (428 IVF-ET and 115 GIFT) in 422 infertile patients.
  
  
  METHODS
  Controlled ovarian hyperstimulation (COH) and IVF-ET or GIFT.
  
  
  METHODS
  The incongruity ratio as a parameter of the asymmetry in follicular development and pregnancy rate (PR).
  
  
  RESULTS
  For GIFT cycles, the PRs were 37.8% and 15.7% in cycles with congruent and incongruent follicular development, respectively. However, for IVF-ET cycles, the PR was not affected by incongruent follicular development: 28.2% and 29.0%, respectively. An inverse relationship was observed between the degree of incongruity and the estimated probability of pregnancy in GIFT cycles but not in IVF-ET cycles. Neither the side of the dominant ovary nor the degree of incongruity were consistent in consecutive cycles.
  
  
  CONCLUSIONS
  Incongruent follicular development during COH has a significantly negative influence on the outcome of GIFT cycles but not on the outcome of IVF-ET cycles. The reason for this difference is not clear. We recommend considering IVF-ET instead of GIFT if incongruent follicular development occurs.
authors.affiliation: Monash In Vitro Fertilization, and Monash University, Melbourne, Victoria, Australia. gevasam@internet-zahav.net
authors.forename: T
authors.initials: T
authors.lastname: Eldar-Geva
authors.forename: P J
authors.initials: PJ
authors.lastname: Lowe
authors.forename: V
authors.initials: V
authors.lastname: MacLachlan
authors.forename: L
authors.initials: L
authors.lastname: Rombauts
authors.forename: D L
authors.initials: DL
authors.lastname: Healy
mesh_terms: D000328:Adult; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D015181:Gamete Intrafallopian Transfer; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy; D016015:Logistic Models; D006080:Ovarian Follicle / Q000254:growth & development*; D016471:Ovarian Hyperstimulation Syndrome; D011247:Pregnancy; D018873:Pregnancy Rate; D012044:Regression Analysis; D012189:Retrospective Studies