Structure, use, and validation of the IEUBK model.
The potential impact of the effects of lead in children is a major concern. Although measurements of lead concentration can be made in a geographic area, it is difficult to predict the effects of this exposure that involve complicated biologic functions. Dynamic mathematical models that can be simulated on a digital computer provide one method of analysis to facilitate the prediction process. The integrated exposure uptake biokinetic (IEUBK) model is a dynamic mathematical model that has been discretized for execution on a digital computer. This paper is concerned with the general difficulties in validating a dynamic model of this type. A number of the general pitfalls of validating a model of this type are presented. The illustrations are of a general nature not requiring an understanding of the physiologic effects of lead on children. The concept of validating a model by comparing results to historical data is discussed. A comparison is made with traditional modeling efforts having this form of dynamic model. Also included are general mathematic concepts illustrating potential difficulties with intuitive analyses in calibrating a dynamic model.
Mickle
M H
MH
Department of Electrical Engineering, University of Pittsburgh, PA 15261, USA. mickle@ee.pitt.edu
D000818:Animals; D004785:Environmental Pollutants / Q000493:pharmacokinetics* / Q000633:toxicity*; D006801:Humans; D007854:Lead / Q000493:pharmacokinetics* / Q000633:toxicity*; D008954:Models, Biological; D015203:Reproducibility of Results
D004785:Environmental Pollutants; D007854:Lead