[Application of modified comparative genomic hybridization in the genetic analysis of 5 lymphoid neoplasms].
To analyze the utility of performing modified comparative genomic hybridization (mCGH) as a complementary technique to conventional cytogenetic techniques in the genetic analysis of lymphoid neoplasms. Modified comparative genomic hybridization and subsequent FISH techniques were performed in 5 lymphoid neoplasms cases diagnosed in Fundación Jiménez Díaz. The latter was done in order to confirm the results obtained with mCGH. Gains of chromosomal regions not detected with conventional cytogenetic techniques were detected by mCGH. A good correlation in the results obtained between conventional cytogenetic and mCGH techniques was observed. Nevertheless, mCGH enables the detection and subsequent identification of gains of genetic sequences undetectable with cytogenetic techniques with possible diagnostic and prognostic value.
Arranz
E
E
Departamento de Genética, Fundación Jiménez Díaz, Madrid.
Martínez-Delgado
B
B
Richart
A
A
Prieto
E
E
García
M
M
Rivas
C
C
Benítez
J
J
D002879:Chromosomes, Human, Pair 10; D002880:Chromosomes, Human, Pair 11; D002889:Chromosomes, Human, Pair 2; D002897:Chromosomes, Human, Pair 7; D002898:Chromosomes, Human, Pair 8; D004247:DNA / Q000737:chemistry*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008223:Lymphoma / Q000235:genetics*; D009693:Nucleic Acid Hybridization / Q000379:methods*
D004247:DNA
Aplicación de la hibridación genómica comparativa modificada en 5 neoplasias linfoides.