Guide for judicious use of the paracetamol absorption technique in a study of gastric emptying rate of liquids.
The paracetamol absorption technique, a widely used method for evaluating the gastric emptying rate of liquids, appears to be performed inappropriately, resulting from a lack of consideration of pharmacokinetics in paracetamol absorption. This review suggests that appropriate study designs and logical choice of the parameters for the rate of paracetamol absorption are the cornerstone of reliable investigation of gastric emptying using the paracetamol method.
Sanaka
M
M
Department of Internal Medicine, School of Medicine, Teikyo University, Tokyo, Japan.
Kuyama
Y
Y
Yamanaka
M
M
D000082:Acetaminophen / Q000493:pharmacokinetics*; D000284:Administration, Oral; D019540:Area Under Curve; D003430:Cross-Sectional Studies; D005746:Gastric Emptying / Q000187:drug effects*; D017408:Guidelines as Topic; D006801:Humans; D007408:Intestinal Absorption; D008962:Models, Theoretical; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014867:Water / Q000378:metabolism*
D014867:Water; D000082:Acetaminophen