A comparative investigation of the restorative effects of roxithromycin on neutrophil activities.
The effects of roxithromycin, a macrolide antibiotic, on neutrophil activities were investigated in six seriously handicapped patients with severe mental retardation. Neutrophil activities were evaluated by flow cytometry using a heparinized blood analysis method. All six patients showed decreased levels of neutrophil phagocytosis, intracellular killing, and CD11b expression. Treatment with roxithromycin in vitro selectively restored the decreased phagocytic and bactericidal activities of neutrophils in these patients. There was no significant restorative effect with cefaclor, ofloxacin, or aztreonam. These results suggest the need to consider therapeutic effects of antibiotics on neutrophil functions in patients at increased risk for bacterial infections due to decreased neutrophil activities.
Noma
T
T
Department of Pediatrics, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Hayashi
M
M
Yoshizawa
I
I
Aoki
K
K
Shikishima
Y
Y
Kawano
Y
Y
D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology; D001398:Aztreonam / Q000494:pharmacology; D001770:Blood Bactericidal Activity / Q000187:drug effects; D002433:Cefaclor / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology; D002648:Child; D006233:Persons with Disabilities; D004347:Drug Interactions; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D016177:Macrophage-1 Antigen / Q000096:biosynthesis; D008297:Male; D008997:Monobactams / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology* / Q000378:metabolism; D015242:Ofloxacin / Q000494:pharmacology; D010587:Phagocytosis / Q000187:drug effects; D015575:Roxithromycin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D002511:Cephalosporins; D016177:Macrophage-1 Antigen; D008997:Monobactams; D015575:Roxithromycin; D002433:Cefaclor; D015242:Ofloxacin; D006861:Hydrogen Peroxide; D001398:Aztreonam