title: Increased urinary excretion of bilirubin metabolites in association with hyperbilirubinemia after esophagectomy.
abstract: This study was conducted to investigate the rationale for postoperative hyperbilirubinemia after major surgery. The serum bilirubin values and urinary excretion of bilirubin metabolites (BM) were monitored in 11 patients who underwent esophagectomy via right thoracotomy for esophageal cancer. Both the serum bilirubin values and the urinary excretion of BM increased postoperatively in all patients. The maximum serum bilirubin level in four patients with septic complications, two of whom developed pneumonia and two, anastomotic leakage (group A), was significantly higher at 5.25+/-4.16 mg/dl than in the remaining patients without septic complications (group B), at 2.11+/-0.07 mg/dl. The peak value of urinary BM was 99.5+/-88.2 micromol/day in group A and 23.5 +/-26.7 micromol/day in group B. The correlation between the level of serum bilirubin and urinary BM excretion was found to be significant. Thus, the metabolism of bilirubin was increased by extensive surgical stress and septic insult.
authors.affiliation: Department of Surgery II, Osaka University Medical School, Suita, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tsujinaka
authors.forename: J
authors.initials: J
authors.lastname: Fujita
authors.forename: T
authors.initials: T
authors.lastname: Morimoto
authors.forename: A
authors.initials: A
authors.lastname: Ogawa
authors.forename: C
authors.initials: C
authors.lastname: Ebisui
authors.forename: M
authors.initials: M
authors.lastname: Yano
authors.forename: H
authors.initials: H
authors.lastname: Shiozaki
authors.forename: M
authors.initials: M
authors.lastname: Monden
authors.forename: T
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: H
authors.initials: H
authors.lastname: Nakajima
mesh_terms: D000368:Aged; D001663:Bilirubin / Q000097:blood / Q000378:metabolism* / Q000652:urine; D016629:Esophagectomy; D005260:Female; D006801:Humans; D006932:Hyperbilirubinemia / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000378:metabolism*; D013312:Stress, Physiological / Q000378:metabolism*
chemical_list: D001663:Bilirubin