title: Synthesis of sialyl Lewis X mimetics using the Ugi four-component reaction.
abstract: Application of the Ugi four-component condensation to rapidly synthesize a library of glycopeptide mimics of the tetrasaccharide SLe(x) as inhibitors of E- and P-selectin, and to study the effect of varied functionality in mimics on the inhibition is described.
authors.affiliation: Department of Chemistry, Scripps Research Institute, La Jolla, CA 92037, USA.
authors.forename: C Y
authors.initials: CY
authors.lastname: Tsai
authors.forename: W K
authors.initials: WK
authors.lastname: Park
authors.forename: G
authors.initials: G
authors.lastname: Weitz-Schmidt
authors.forename: B
authors.initials: B
authors.lastname: Ernst
authors.forename: C H
authors.initials: CH
authors.lastname: Wong
mesh_terms: D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D015195:Drug Design; D019040:E-Selectin / Q000378:metabolism*; D006020:Glycopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007202:Indicators and Reagents; D007700:Kinetics; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009844:Oligosaccharides / Q000737:chemistry*; D019007:P-Selectin / Q000378:metabolism*; D019151:Peptide Library; D000080506:Sialyl Lewis X Antigen; D013329:Structure-Activity Relationship
chemical_list: D019040:E-Selectin; D006020:Glycopeptides; D007202:Indicators and Reagents; D009842:Oligopeptides; D009844:Oligosaccharides; D019007:P-Selectin; D019151:Peptide Library; D000080506:Sialyl Lewis X Antigen