Reversal of multidrug resistance (MDR) by aspidofractinine-type indole alkaloids.
A series of indole alkaloids of the aspidofractinine-type was assessed for their potential in reversing MDR in vincristine-resistant KB cells. Of the compounds tested, kopsiflorine, kopsamine, pleiocarpine, 11-methoxykopsilongine, lahadinine A and N-methoxycarbonyl-11,12-methylenedioxy-delta 16,17-kopsinine were found to show appreciable activity.
Kam
T S
TS
Department of Chemistry, University of Malaya, Kuala Lumpur, Malaysia.
Subramaniam
G
G
Sim
K M
KM
Yoganathan
K
K
Koyano
T
T
Toyoshima
M
M
Rho
M C
MC
Hayashi
M
M
Komiyama
K
K
D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D014750:Vincristine / Q000494:pharmacology
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D007211:Indoles; C061457:kopsinine F; D014750:Vincristine