title: Zinc deficiency aggravates tubulointerstitial nephropathy caused by ureteral obstruction.
abstract: Ureteral ligation causes tubulointerstitial nephropathy characterized by the tubular dilatation, the interstitial expansion, and a leukocyte infiltration into the tubulointerstitium. The present study was designed to explore whether zinc (Zn) deficiency affects the development of unilateral ureteral obstruction (UUO)-induced tubulointerstitial nephropathy. Compared to rats fed a standard diet, rats fed a Zn-deficient diet exhibited a greater influx of leukocytes into the tubulointerstitium of the cortex of the obstructed kidney 3 d following UUO. Furthermore, rats fed a Zn-deficient diet showed a slight invasion of leukocytes into the tubulointerstitium of the cortex of the contralateral nonobstructed kidney (CLK), although there was no infiltration of leukocytes into the CLK of rats fed a standard diet. These histological changes, however, were ameliorated by administration of enalapril, an angiotensin (ANG) I-converting enzyme inhibitor. Thus, it is suggested that Zn deficiency aggravates UUO-induced tubulointerstitial nephropathy via an increase in the action of ANG II.
authors.affiliation: Department of Hygiene and Preventive Medicine, Faculty of Medicine, Saitama Medical School, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yanagisawa
authors.forename: M
authors.initials: M
authors.lastname: Nodera
authors.forename: O
authors.initials: O
authors.lastname: Wada
mesh_terms: D000818:Animals; D003300:Copper / Q000032:analysis; D003677:Deficiency Diseases / Q000150:complications*; D007668:Kidney / Q000737:chemistry; D008297:Male; D009395:Nephritis, Interstitial / Q000150:complications* / Q000209:etiology / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014517:Ureteral Obstruction / Q000150:complications*; D015032:Zinc / Q000032:analysis / Q000172:deficiency*
chemical_list: D003300:Copper; D015032:Zinc