title: Synthesis and preliminary evaluation of (S)-2-(4'-carboxycubyl)glycine, a new selective mGluR1 antagonist.
abstract: The synthesis and the pharmacological evaluation at metabotropic glutamate receptors of S-2-(4'-carboxy-cubyl)glycine (ACUDA, 9) are described. S-2-(4'-Carboxy-cubyl)glycine is a structurally novel group I selective antagonist for mGluR1 subtype.
authors.affiliation: Istituto di Chimica e Tecnologia del Farmaco, Università degli Studi, Perugia, Italy. rp@unipg.it
authors.forename: R
authors.initials: R
authors.lastname: Pellicciari
authors.forename: G
authors.initials: G
authors.lastname: Costantino
authors.forename: E
authors.initials: E
authors.lastname: Giovagnoni
authors.forename: L
authors.initials: L
authors.lastname: Mattoli
authors.forename: I
authors.initials: I
authors.lastname: Brabet
authors.forename: J P
authors.initials: JP
authors.lastname: Pin
mesh_terms: D001952:Bridged-Ring Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D018691:Excitatory Amino Acid Antagonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005998:Glycine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007295:Inositol Phosphates / Q000096:biosynthesis / Q000378:metabolism; D015394:Molecular Structure; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors*; D014162:Transfection
chemical_list: C116729:2-(4'-carboxycubyl)glycine; D001952:Bridged-Ring Compounds; D018691:Excitatory Amino Acid Antagonists; D007295:Inositol Phosphates; D018094:Receptors, Metabotropic Glutamate; D005998:Glycine