title: Diagnostic value of troponin T in neonates of mild pre-eclamptic mothers.
abstract: The measurement of myocardial damage by newer, highly specific markers of myocardial damage is now possible, including cardiac structural proteins such as troponin T (TnT). In neonates of pre-eclamptic mothers, it identifies minor myocardial damage missed by other biochemical markers. The present study was designed to determine the diagnostic value of TnT concentrations in neonates of pre-eclamptic mothers. Fifteen neonates of pre-eclamptic mothers were studied (9 boys and 6 girls), and 17 healthy full-term neonates (9 boys and 8 girls) were selected as a control group. The serum TnT concentration in neonates of pre-eclamptic mothers (0.70 ng/ml) was significantly higher than that in the control group (0.10 ng/ml). In an echocardiographic study, the mean mitral peak velocity at an atrial contraction (A) value of 39 cm/s in neonates of pre-eclamptic mothers was significantly lower than that in the control group (53 cm/s), and the mean mitral peak velocity of early diastole to peak velocity of the atrial contraction (E/A) value (1.75) in neonates of pre-eclamptic mothers was significantly higher than that in the control subjects (1.23). In conclusion, our study demonstrated high levels of cardiac TnT, lower mitral A values and high mitral E/A values in neonates of pre-eclamptic mothers, presumably associated with mild myocardial damage in the neonates of pre-eclamptic mothers.
authors.affiliation: Department of Pediatrics, Erciyes University Medical Faculty, Kayseri, Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Narin
authors.forename: N
authors.initials: N
authors.lastname: Cetin
authors.forename: H
authors.initials: H
authors.lastname: Kiliç
authors.forename: M
authors.initials: M
authors.lastname: Başbuğ
authors.forename: F
authors.initials: F
authors.lastname: Narin
authors.forename: M
authors.initials: M
authors.lastname: Kafali
authors.forename: K
authors.initials: K
authors.lastname: Uzüm
authors.forename: E
authors.initials: E
authors.lastname: Genç
authors.forename: H B
authors.initials: HB
authors.lastname: Ustünbaş
mesh_terms: D009202:Cardiomyopathies / Q000097:blood / Q000175:diagnosis* / Q000209:etiology*; D004452:Echocardiography; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009200:Myocardial Contraction; D011225:Pre-Eclampsia / Q000097:blood / Q000150:complications*; D011247:Pregnancy; D012016:Reference Values; D020107:Troponin T / Q000097:blood*
chemical_list: D020107:Troponin T