Fabrication of multiunit controlled-release phenylpropanolamine hydrochloride tablets.
Phenylpropanolamine hydrochloride (PPA) pellets were prepared in a fluidized-bed rotary granulator. Microcrystalline cellulose and distilled water were used as pelletization enhancer and binder, respectively. The pellets were coated with methacrylate ester copolymer (Eudragit RS 100) solution containing a 1:1 ratio mixture of triethyl citrate and castor oil as plasticizers. The addition of approximately 30% microcrystalline cellulose and 2% croscarmellose sodium to the 50% coated pellets produced fast disintegrating tablets. Dissolution profiles of both pellets and their respective matrix tablets were comparable and conformed to the USP dissolution requirement for PPA extended-release capsules.
Mitrevej
A
A
Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
Sinchaipanid
N
N
Natpoolwat
N
N
Naratikornrit
N
N
D003692:Delayed-Action Preparations; D004343:Drug Implants; D010665:Phenylpropanolamine / Q000493:pharmacokinetics*; D012995:Solubility; D013607:Tablets
D003692:Delayed-Action Preparations; D004343:Drug Implants; D013607:Tablets; D010665:Phenylpropanolamine