title: Hydroindenic-guanylhydrazones. Synthesis and evaluation as inotropic agents.
abstract: The synthesis and inotropic activity of two families of hydroindenic compounds are described. Among them, a bis-guanylhydrazone derivative has demonstrated to produce an interesting positive inotropic effect on guinea pig atria, displaying at higher dosis a similar effect to that elicited by digoxin.
authors.affiliation: Laboratorio de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad de Salamanca, Spain.
authors.forename: C P
authors.initials: CP
authors.lastname: Melero
authors.forename: L G
authors.initials: LG
authors.lastname: Sevillano
authors.forename: E
authors.initials: E
authors.lastname: Caballero
authors.forename: F
authors.initials: F
authors.lastname: Tomé
authors.forename: R
authors.initials: R
authors.lastname: Carrón
authors.forename: M J
authors.initials: MJ
authors.lastname: Montero
authors.forename: A
authors.initials: A
authors.lastname: San Feliciano
authors.forename: M
authors.initials: M
authors.lastname: Medarde
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D013329:Structure-Activity Relationship
chemical_list: D002316:Cardiotonic Agents