title: In vitro selection of phosphorothiolated aptamers.
abstract: A pool of RNA molecules that contained exclusively phosphorothioate internucleoside linkages was used as a starting point for the selection of aptamers that bind to basic fibroblast growth factor (bFGF), and appear to act as heparin mimics.
authors.affiliation: Institute for Cellular and Molecular Biology, University of Texas, Austin 78712, USA.
authors.forename: S
authors.initials: S
authors.lastname: Jhaveri
authors.forename: B
authors.initials: B
authors.lastname: Olwin
authors.forename: A D
authors.initials: AD
authors.lastname: Ellington
mesh_terms: D001483:Base Sequence; D001665:Binding Sites; D003001:Cloning, Molecular; D004247:DNA / Q000737:chemistry*; D017931:DNA Primers / Q000737:chemistry; D016222:Fibroblast Growth Factor 2 / Q000235:genetics / Q000378:metabolism*; D006493:Heparin / Q000378:metabolism; D006801:Humans; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D012313:RNA / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D011994:Recombinant Proteins / Q000378:metabolism; D013698:Templates, Genetic; D013873:Thionucleotides; D014158:Transcription, Genetic
chemical_list: D017931:DNA Primers; D009838:Oligodeoxyribonucleotides; D011994:Recombinant Proteins; D013873:Thionucleotides; D016222:Fibroblast Growth Factor 2; D012313:RNA; D006493:Heparin; D004247:DNA