Voltage-dependent ion channel formation by rigid rod-shaped polyols in planar lipid bilayers.
In this Letter, we describe the appearance of large, voltage-dependent currents in BLM induced by rigid rod-shaped polyols that function without charge and permanent dipole moment. The capacity of these symmetrical, nonpeptide models to form either short-living nanopores or small ion channels is shown to depend critically on the length of rigid-rod scaffold as well as the nature of the lateral side chains.
Sakai
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Department of Chemistry, Georgetown University, Washington, DC 20057, USA.
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Bezrukov
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Matile
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D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004553:Electric Conductivity; D015640:Ion Channel Gating / Q000502:physiology; D007473:Ion Channels / Q000737:chemistry* / Q000502:physiology*; D008051:Lipid Bilayers / Q000737:chemistry*; D008968:Molecular Conformation; D011108:Polymers / Q000737:chemistry; D013402:Sugar Alcohols / Q000737:chemistry*
D007473:Ion Channels; D008051:Lipid Bilayers; D011108:Polymers; D013402:Sugar Alcohols