title: Synthesis and antioxidant activity of novel amphipathic derivatives of tea polyphenol.
abstract: Hydrophobic derivatives of a tea polyphenol have been synthesized. 6, 8-Bis(octylthiomethyl)-epigallocatechin 3-O-gallate, 6, 8-bis(octylthiomethyl)-4 beta-(2-hydroxyethylthio)epigallocatechin 3-O-gallate and epigallocatechin 3-O-[4-O-(N-octadecylcarbamoyl)gallate] showed strong inhibition activity against lipid peroxidation of liposome caused by both lipid-soluble and water-soluble radical generators.
authors.affiliation: School of Pharmaceutical Sciences, Nagasaki University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
authors.forename: R
authors.initials: R
authors.lastname: Kusano
authors.forename: I
authors.initials: I
authors.lastname: Kouno
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology; D002392:Catechin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008051:Lipid Bilayers; D015227:Lipid Peroxidation / Q000187:drug effects; D013662:Tea / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D008051:Lipid Bilayers; D013662:Tea; D002392:Catechin; C045651:epigallocatechin gallate