title: Amygdalin binds to the CD4 receptor as suggested from molecular modeling studies.
abstract: The geometrical features of the proposed bioactive conformation of peptide T assessed by computational methods in a previous study, together with available structure-activity studies on peptide T, led us to propose a pharmacophore for the CD4-peptide T interaction. Subsequent, data base searching permitted us to identify amygdalin as a peptide T peptidomimetic.
authors.affiliation: Dept. d'Enginyeria Quimica, Universitat Politecnica de Catalunya, ETSEIB, Barcelona, Spain.
authors.forename: O
authors.initials: O
authors.lastname: Llorens
authors.forename: M
authors.initials: M
authors.lastname: Filizola
authors.forename: S
authors.initials: S
authors.lastname: Spisani
authors.forename: M
authors.initials: M
authors.lastname: Marastoni
authors.forename: C
authors.initials: C
authors.lastname: Herranz
authors.forename: J J
authors.initials: JJ
authors.lastname: Perez
mesh_terms: D000678:Amygdalin / Q000737:chemistry* / Q000378:metabolism*; D001665:Binding Sites; D015704:CD4 Antigens / Q000737:chemistry* / Q000378:metabolism*; D002634:Chemotaxis, Leukocyte; D006801:Humans; D066298:In Vitro Techniques; D007963:Leukocytes, Mononuclear / Q000276:immunology / Q000502:physiology*; D008958:Models, Molecular; D015717:Peptide T / Q000031:analogs & derivatives / Q000737:chemistry* / Q000378:metabolism*; D011487:Protein Conformation
chemical_list: D015704:CD4 Antigens; D015717:Peptide T; D000678:Amygdalin