title: Applications of computer modelling for the design of orthopaedic, dental and cardiovascular biomaterials.
abstract: Biomaterials do not escape from the general trend present in all contemporary science and technology towards increasing use of computers and information technology. In this paper the use of computer modelling for the design of biomaterials is discussed. The word 'biomaterials' is interpreted in its broadest sense, i.e. referring to any foreign object brought into the body for temporary or permanent use. Computer modelling will first be discussed as a tool to model biological structures (bones, arteries) or to investigate and simulate biological interactions at implant-host interfaces. It will then be illustrated how computer modelling, using insights gained from the modelling of the biological structures themselves, is used in the design process of dental, orthopaedic and cardiovascular prostheses. The area of computer modelling for biomaterials applications has become so vast that an exhaustive overview is impossible in the framework of one paper. Rather, some illustrative case studies will be discussed which are, in the opinion of the authors, representative of general trends in this challenging domain of science on the boundary between engineering and medicine.
authors.affiliation: Division of Biomechanics and Engineering Design, K U Leuven, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Vander Sloten
authors.forename: M C
authors.initials: MC
authors.lastname: Hobatho
authors.forename: P
authors.initials: P
authors.lastname: Verdonck
mesh_terms: D002318:Cardiovascular Diseases / Q000601:surgery*; D003198:Computer Simulation; D003793:Dental Restoration, Permanent; D004867:Equipment Design; D004864:Equipment and Supplies / Q000592:standards*; D020342:Finite Element Analysis; D006801:Humans; D008954:Models, Biological; D009984:Orthopedic Fixation Devices / Q000592:standards*; D019736:Prostheses and Implants / Q000592:standards*