[A model of chronic situational stress and its effect on the rate of aging and the longevity of rats].
In rat experiments a new model of situational chronic stress, with the use of multicomponent natural stimulating influences, has been elaborated. The study revealed two subpopulations with longer and shorter lifespan in the group of stressed rats vs. control group. The survival of stressed animals was correspondent with the changes of adaptive indices. Thus the situational chronic stress has the geropromotive or geroprotective effect which depends on the organism's adaptive capacities.
Frol'kis
V V
VV
Institute of Gerontology, Academy of Medical Sciences of Ukraine, Kiev.
Verkhrats'kyĭ
N S
NS
Myhovan
S A
SA
Dubileĭ
T O
TO
Rushkevych
Iu Ie
IuIe
D000222:Adaptation, Physiological; D000375:Aging / Q000502:physiology*; D000818:Animals; D002908:Chronic Disease; D003345:Corticosterone / Q000097:blood; D004195:Disease Models, Animal; D008136:Longevity / Q000502:physiology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000097:blood / Q000503:physiopathology*; D013997:Time Factors
D003345:Corticosterone
Model' khronichnoho sytuatsiĭnoho stresu ta ĭoho vplyv na temp starinnia i tryvalist' zhyttia shchuriv.