Synthesis and biological activity of novel thiazolidinediones.
Novel compounds having a dual pharmacophore were synthesised and evaluated for their insulin sensitiser and anti-inflammatory properties in different animal models.
Prabhakar
C
C
Department of Process Research and Development, Dr. Reddy's Research Foundation, Miyapur, Hyderabad, India.
Madhusudhan
G
G
Sahadev
K
K
Reddy
C M
CM
Sarma
M R
MR
Reddy
G O
GO
Chakrabarti
R
R
Rao
C S
CS
Kumar
T D
TD
Rajagopalan
R
R
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology*; D001786:Blood Glucose / Q000187:drug effects; D002074:Butanones / Q000494:pharmacology; D002839:Chromans / Q000494:pharmacology; D004487:Edema / Q000188:drug therapy; D005260:Female; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D008297:Male; D051379:Mice; D000077430:Nabumetone; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D045162:Thiazolidinediones; D000077288:Troglitazone
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001786:Blood Glucose; D002074:Butanones; D002839:Chromans; D007004:Hypoglycemic Agents; D013844:Thiazoles; D045162:Thiazolidinediones; D000077288:Troglitazone; D000077430:Nabumetone; C115174:netoglitazone