title: Synthesis and structure-activity relationship studies of substituted isoquinoline analogs as antitumor agent.
abstract: A number of substituted isoquinolin-1-ones, possible bioisosteres of the 5-aryl substituted 2,3-dihydroimidazo[2,1-a]isoquinolines, were synthesized and tested for their antitumor activity against five different human tumor cell lines. O-(3-hydroxypropyl) substituted compound (15) exhibited the best antitumor activity which is 3-5 times better than 5-[4'-(piperidinomethyl) phenyl]-2,3-dihydroimidazo[2,1-a]isoquinoline (1).
authors.affiliation: College of Pharmacy, Chonnam National University, Kwangju, Korea.
authors.forename: S H
authors.initials: SH
authors.lastname: Cheon
authors.forename: J S
authors.initials: JS
authors.lastname: Park
authors.forename: B H
authors.initials: BH
authors.lastname: Chung
authors.forename: B G
authors.initials: BG
authors.lastname: Choi
authors.forename: W J
authors.initials: WJ
authors.lastname: Cho
authors.forename: S U
authors.initials: SU
authors.lastname: Choi
authors.forename: C O
authors.initials: CO
authors.lastname: Lee
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D007546:Isoquinolines