Developmental changes of cortical and cerebellar motor control: a clinical positron emission tomography study with children and adults.
Functional neuroimaging data regarding the development of motor organization in normal children and adolescents are virtually unavailable because of ethical concerns. As an alternative approach, we studied child and adult lesion patients, focusing on movement of the hand ipsilateral to the lesion and on brain activations in the contralesional hemisphere. [15O]-water positron emission tomography was performed during rest and sequential finger-thumb tapping in 10 children (aged 6 to 14 years) and 15 adults (aged 18 to 74 years) with unilateral lesion. We expected more distinct activation/deactivation patterns during movement in adults than in children. While there were no group differences in activation of primary and secondary motor cortices, deactivations in nonmotor cortex were significantly more pronounced in adults than in children. This indirectly supports our hypothesis of developmental focalization of cerebral motor control. Activations in the cerebellum and vermis were significantly stronger in the adults than in the children, possibly reflecting normal developmental patterns.
Müller
R A
RA
Department of Pediatrics, Wayne State University Medical School, Detroit, MI, USA.
Rothermel
R D
RD
Behen
M E
ME
Muzik
O
O
Mangner
T J
TJ
Chugani
H T
HT
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D001932:Brain Neoplasms / Q000503:physiopathology; D002531:Cerebellum / Q000000981:diagnostic imaging / Q000502:physiology*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000502:physiology*; D002560:Cerebrovascular Circulation; D002648:Child; D004827:Epilepsy / Q000503:physiopathology; D005260:Female; D005385:Fingers / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009048:Motor Skills / Q000502:physiology*; D009068:Movement / Q000502:physiology; D014055:Tomography, Emission-Computed