title: Ocular hypotony after laser suture lysis following trabeculectomy with mitomycin C.
abstract: BACKGROUND
  To report our experience with laser suture lysis (LSL) following trabeculectomy with mitomycin C, its timing, effectiveness and related complications.
  
  
  METHODS
  We retrospectively examined 38 consecutive eyes of 36 patients that underwent LSL following trabeculectomy with mitomycin C.
  
  
  RESULTS
  The mean preLSL intraocular pressure (IOP) was 27.0 mm Hg (SD 6.3, range 16-39 mm Hg) and the postLSL IOP (IOP 1 h after the last session of LSL) was 16.0 mm Hg (SD 7.2, range 3-31 mm Hg). Following the LSL in 7 eyes (7 of 38) hypotony (IOP<6 mm Hg, lasting more than 24 h) developed. Two groups were defined. In group I no hypotony was found after LSL and group II went through a period of hypotony. The time interval between surgery and LSL was significantly shorter in group II (mean 5.7, SD 7.5, range 1-19 days), compared to group I ( mean 14.7, SD 13.0, range 1-44 days) (p=0.041). The mean final IOP (IOP measured at the last visit) was 13.3 mm Hg (SD 3.4, range 6-20 mm Hg) and mean follow-up was 6.1 months (SD 3.9, range 2.0-15.2 months). No hypotony was found at final examination. PostLSL IOP and final IOP were significantly lower in group II (p=0.002 and p=0.024 respectively). IOP reduction by LSL was significantly greater in group II (p=0.046).
  
  
  CONCLUSIONS
  LSL is an effective and safe procedure to lower the IOP following trabeculectomy with mitomycin C. Early application of LSL results in lower final IOPs, but has a higher risk of hypotony.
authors.affiliation: Institute of Ophthalmology, University Hospital Nijmegen, The Netherlands.
authors.forename: Y
authors.initials: Y
authors.lastname: Bardak
authors.forename: M H
authors.initials: MH
authors.lastname: Cuypers
authors.forename: M A
authors.initials: MA
authors.lastname: Tilanus
authors.forename: C A
authors.initials: CA
authors.lastname: Eggink
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D005901:Glaucoma / Q000188:drug therapy / Q000601:surgery; D006801:Humans; D007429:Intraocular Pressure; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use*; D015814:Ocular Hypotension / Q000209:etiology / Q000601:surgery*; D009883:Ophthalmic Solutions; D012189:Retrospective Studies; D012590:Sclera / Q000601:surgery*; D013524:Surgical Flaps; D013536:Suture Techniques; D014130:Trabeculectomy / Q000009:adverse effects*
chemical_list: D009883:Ophthalmic Solutions; D016685:Mitomycin