[Study in the combining quantity of Con A-binding sites on membrane surface of artesunate-resistance strain of Plasmodium berghei].
OBJECTIVE
To study the production mechanism of plasmodium berghei (PB) in resisting artesunate.


METHODS
The combining quantity of Con A-binding sites on membrane surface of PB trophozoite labelled with fluorescein isothiocyanate (FITC) of Con A was determined by fluoromicrospectrophotometer.


RESULTS
The combining quantity of PB artesunate-resistance strain (PBAR) was reduced significantly than that of PB normal strain (P < 0.01).


CONCLUSIONS
The type of glucose in surface membrane of PBAR has changed and the changes of membrane fluidity could be one of the causes of the change in the combining quantity of Con A-binding sites on membrane of PBAR.
Liu
A R
AR
Institute of Traditional Chinese Medicine and Materia Medica of Shandong, Jinan.
Zhao
D P
DP
Sui
Z Y
ZY
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D037621:Artemisinins; D000077332:Artesunate; D001665:Binding Sites / Q000187:drug effects; D003208:Concanavalin A / Q000378:metabolism; D004351:Drug Resistance; D008297:Male; D008560:Membrane Fluidity / Q000187:drug effects; D008562:Membrane Glycoproteins / Q000378:metabolism; D051379:Mice; D010962:Plasmodium berghei / Q000187:drug effects* / Q000378:metabolism; D011952:Receptors, Concanavalin A / Q000378:metabolism*; D012717:Sesquiterpenes / Q000494:pharmacology*
D000962:Antimalarials; D037621:Artemisinins; D008562:Membrane Glycoproteins; D011952:Receptors, Concanavalin A; D012717:Sesquiterpenes; D003208:Concanavalin A; D000077332:Artesunate