title: Docetaxel and cyclophosphamide induced remission in platinum and paclitaxel refractory ovarian cancer.
abstract: Platinum-based chemotherapy is the standard treatment for advanced ovarian cancer, with response rates of 40-60%. In patients who fail platinum treatment, paclitaxel has resulted in response rates of 10-48%. Docetaxel has partial non-cross-resistance with and is twice as potent in vitro as paclitaxel in inhibiting microtubule disaggregation. The combination of docetaxel and cyclophosphamide is synergistic in pre-clinical studies and clinically active in breast cancer. We present the case of a patient with platinum and paclitaxel refractory ovarian cancer who achieved a remission with docetaxel and cyclophosphamide.
authors.affiliation: Siriraj Hospital, Bangkok, Thailand.
authors.forename: M
authors.initials: M
authors.lastname: Benjapibal
authors.forename: A P
authors.initials: AP
authors.lastname: Kudelka
authors.forename: A
authors.initials: A
authors.lastname: Vasuratna
authors.forename: C L
authors.initials: CL
authors.lastname: Edwards
authors.forename: C F
authors.initials: CF
authors.lastname: Verschraegen
authors.forename: V
authors.initials: V
authors.lastname: Valero
authors.forename: S
authors.initials: S
authors.lastname: Vadhan-Raj
authors.forename: J J
authors.initials: JJ
authors.lastname: Kavanagh
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018394:CA-125 Antigen / Q000097:blood; D002277:Carcinoma / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D003520:Cyclophosphamide / Q000008:administration & dosage; D018283:Cystadenocarcinoma, Papillary / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D000077143:Docetaxel; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D017239:Paclitaxel / Q000008:administration & dosage / Q000031:analogs & derivatives; D043823:Taxoids
chemical_list: D018394:CA-125 Antigen; D043823:Taxoids; D000077143:Docetaxel; D003520:Cyclophosphamide; D017239:Paclitaxel