[Clinical study on jianfei pill in preventing and treating recurrence of infantile asthma].
OBJECTIVE
Further explore on preventing and treating recurrence of infantile asthma with TCM method and its mechanism.


METHODS
Using Jianfei Pill (JFP) which was prepared according to the therapeutic principle of strengthening the body resistance to consolidate the constitution and promoting blood circulation to remove obstruction in the channels in treating 56 patients suffering from asthma. Their pulmonary functions were observed.


RESULTS
A total effective rate of 91.1% was shown in JFP group, which was higher than that of the control group (60%), P < 0.01. In comparison with the control group, the level of serum IgA, IgG and E-rosette ascend significantly (P < 0.01). The wave amplitude of pulmonary impedance rheogram and right heart index (HI) also increased significantly (P < 0.01), while pulmonary arterial pressure (PPA) and pulmonary vascular resistance (PVR) dropped markedly (P < 0.01).


CONCLUSIONS
JFP might work by means of enhancing the immune function and improving the pulmonary microcirculation to control chronic bronchial inflammation and reduce its reactivity to prevent the relapse of asthma.
Zhang
X P
XP
Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan.
Wang
M X
MX
Chen
S H
SH
D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy* / Q000276:immunology / Q000517:prevention & control; D002648:Child; D002675:Child, Preschool; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007665:Ketotifen / Q000627:therapeutic use; D008297:Male; D012008:Recurrence; D012397:Rosette Formation
D018927:Anti-Asthmatic Agents; D004365:Drugs, Chinese Herbal; D006634:Histamine H1 Antagonists; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007665:Ketotifen