[Improvement of learning and memory functions by GABAB receptor antagonists in mice].
In one trial passive avoidance response in mice, the effects of gamma-aminobutyric acid (GABA)B receptor agonist baclofen and antagonist CGP35348 and CGP36742 on acquisition, consolidation and retrieval of memory were observed. The results showed that the antagonists could significantly promote the acquisition impairment induced by baclofen, the consolidation impairment induced by baclofen and NaNO2, and the retrieval impairment induced by baclofen and 30% alcohol. These results suggest that the GABAB receptor antagonists may become a novel type of drug for the treatment of Alzheimer's disease.
Yu
Z F
ZF
Department of Pharmacology, Sun Yat-Sen University of Medical Sciences, Guangzhou.
Hu
B R
BR
Cheng
G J
GJ
D000818:Animals; D001418:Baclofen / Q000037:antagonists & inhibitors / Q000494:pharmacology; D005260:Female; D018756:GABA Antagonists / Q000494:pharmacology*; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D009943:Organophosphorus Compounds / Q000494:pharmacology*
D018756:GABA Antagonists; D009943:Organophosphorus Compounds; C079148:(3-aminopropyl)(n-butyl)phosphinic acid; C066430:CGP 35348; D001418:Baclofen