title: Solid-phase synthesis of oligomeric deoxynucleic guanidine (DNG): a polycationic analogue of DNA.
abstract: DNG is a DNA analogue wherein the negatively charged phosphate backbone linkages have been replaced by achiral positively charged guanidinium linkages and has high affinity for complimentary DNA. The synthesis of these compounds in solution phase has been severely limited due to diminishing yields and solubility limitations. For the first time, an efficient solid-phase synthesis for oligomeric is reported.
authors.affiliation: Department of Chemistry, University of California, Santa Barbara 93106, USA.
authors.forename: B A
authors.initials: BA
authors.lastname: Linkletter
authors.forename: T C
authors.initials: TC
authors.lastname: Bruice
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004247:DNA / Q000138:chemical synthesis* / Q000737:chemistry; D006146:Guanidines / Q000138:chemical synthesis* / Q000737:chemistry; D008627:Mercuric Chloride; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D013890:Thiourea
chemical_list: D006146:Guanidines; C088820:deoxynucleic guanidine; D008627:Mercuric Chloride; D004247:DNA; D013890:Thiourea