Mechanisms mediating multiple physiological responses to gonadotropin-releasing hormone.
A central question in endocrinology is how a single ligand interacting with a single receptor can mediate multiple responses. GnRH interaction with receptor offers a prime example, leading to the regulation of synthesis and release of at least three molecules, regulation of target cell responsiveness and receptor number. The present study suggests a molecular model consistent with extant data that provides a mechanism by which this may occur and, further, which allows for coordinate regulation.
Stanislaus
D
D
Department of Physiology and Pharmacology, Oregon Health Sciences University, Portland 97201, USA.
Pinter
J H
JH
Janovick
J A
JA
Conn
P M
PM
D000818:Animals; D015536:Down-Regulation; D019204:GTP-Binding Proteins / Q000378:metabolism; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism*; D008954:Models, Biological; D011966:Receptors, LHRH / Q000378:metabolism*; D015398:Signal Transduction; D015854:Up-Regulation
D011966:Receptors, LHRH; D007987:Gonadotropin-Releasing Hormone; D019204:GTP-Binding Proteins