Sertoli cell transplants: their use in the treatment of neurodegenerative disease.
The efficacy of treating neurodegenerative diseases with the transplantation of fetal tissue has been demonstrated in animal models of Parkinson's disease, Huntington's disease and stroke. In the clinical setting, neural transplantation as a treatment for patients with Parkinson's disease has shown promising results. However, for this treatment method to be effective neuronal survival needs to be improved through either trophic support or localized immunoprotection. Co-transplanting Sertoli cells, which express many nutritive, regulatory, trophic and immunosuppressive factors, with fetal neural cells could provide both of these requirements. Such a strategy could enhance the recovery benefits associated with transplantation and decrease the need for, and the risks associated with, long-term systemic immunosuppression.
Willing
A E
AE
Division of Neurosurgery, University of South Florida College of Medicine, Tampa 33612, USA.
Cameron
D F
DF
Sanberg
P R
PR
D000818:Animals; D017690:Cell Transplantation; D016332:Fetal Tissue Transplantation; D006085:Graft Survival; D006801:Humans; D008297:Male; D019636:Neurodegenerative Diseases / Q000628:therapy*; D009474:Neurons / Q000276:immunology / Q000637:transplantation; D051381:Rats; D012708:Sertoli Cells / Q000502:physiology / Q000637:transplantation*