title: HMGIC expression patterns in non-small lung cancer and surrounding tissue.
abstract: BACKGROUND
  So far no powerful molecular markers have been found allowing an early detection of lung cancer enabling a higher rate of curative cancer therapy. Based on its expression patterns in other malignant tumors the expression of the high mobility group protein gene HMGIC is a possible new candidate for such a diagnostic marker.
  
  
  METHODS
  The HMGIC expression patterns were determined in samples from 19 non-SCLC, 14 corresponding non-malignant adjacent lung, and 7 pleural tissues by hemi-nested RT-PCR followed by the detection of HMGIC specific amplification products by Southern blot hybridization.
  
  
  RESULTS
  HMGIC expression was found in 14/19 non-SCLC samples. In contrast, expression was not detectable in any of the non-malignant adjacent lung or pleural tissues.
  
  
  CONCLUSIONS
  These results suggest that HMGIC expression may be a potential new and powerful indicator for lung cancer. An HMGIC expression assay may be applicable to sputum or broncho-alveolar lavage fluid samples facilitating early detection of lung cancer.
authors.affiliation: Zentrum fur Humangenetik und Genetische Beratung, Universität Bremen, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Rogalla
authors.forename: K
authors.initials: K
authors.lastname: Drechsler
authors.forename: W
authors.initials: W
authors.lastname: Schröder-Babo
authors.forename: K
authors.initials: K
authors.lastname: Eberhardt
authors.forename: J
authors.initials: J
authors.lastname: Bullerdiek
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism*; D005260:Female; D006609:High Mobility Group Proteins / Q000378:metabolism*; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008175:Lung Neoplasms / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D014408:Biomarkers, Tumor; D006609:High Mobility Group Proteins