title: Acute liver damage with characteristic apoptotic hepatocytes by ingestion of Aplysia kurodai, a sea hare.
abstract: A case of acute liver damage by ingestion of Aplysia kurodai, a sea hare is reported. A 40-year-old man, complaining of vomiting and pyrexia after eating a sea hare, was admitted. Laboratory data showed mild liver damage with sustained elevations of aminotransferases. Microscopic findings in the liver biopsy specimen revealed characteristic apoptotic hepatocytes accompanied by mitotic hepatocytes. It is suggested that bioactive substances in the sea hare might induce such apoptosis of hepatocytes in the liver.
authors.affiliation: Department of Gastroenterology, Kyoto Prefectural Yosanoumi Hospital.
authors.forename: Y
authors.initials: Y
authors.lastname: Sakamoto
authors.forename: T
authors.initials: T
authors.lastname: Nakajima
authors.forename: S
authors.initials: S
authors.lastname: Misawa
authors.forename: H
authors.initials: H
authors.lastname: Ishikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Itoh
authors.forename: T
authors.initials: T
authors.lastname: Nakashima
authors.forename: T
authors.initials: T
authors.lastname: Okanoue
authors.forename: K
authors.initials: K
authors.lastname: Kashima
authors.forename: T
authors.initials: T
authors.lastname: Tsuji
mesh_terms: D000328:Adult; D000818:Animals; D001048:Aplysia; D017209:Apoptosis / Q000187:drug effects; D001706:Biopsy; D005500:Follow-Up Studies; D006801:Humans; D017114:Liver Failure, Acute / Q000139:chemically induced* / Q000201:enzymology / Q000473:pathology*; D008297:Male; D008978:Mollusk Venoms / Q000506:poisoning*; D000637:Transaminases / Q000097:blood
chemical_list: D008978:Mollusk Venoms; D000637:Transaminases