title: Design and synthesis of SH3 domain binding ligands: modifications of the consensus sequence XPpXP.
abstract: Spirolactam-based Pro-Pro mimetics incorporated in the consensus sequence XPpXP, lead to effective nonpeptide ligands of SH3 domains.
authors.affiliation: Cadus Pharmaceutical Corporation, Tarrytown, NY 10591, USA.
authors.forename: D J
authors.initials: DJ
authors.lastname: Witter
authors.forename: S J
authors.initials: SJ
authors.lastname: Famiglietti
authors.forename: J C
authors.initials: JC
authors.lastname: Cambier
authors.forename: A L
authors.initials: AL
authors.lastname: Castelhano
mesh_terms: D001665:Binding Sites; D015195:Drug Design; D008024:Ligands; D008968:Molecular Conformation; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000378:metabolism; D018909:src Homology Domains
chemical_list: D008024:Ligands; D009842:Oligopeptides