Effect of aluminum on superoxide dismutase activity in the adult rat brain.
Male rats were treated daily with an intraperitoneal injection of 15 mg aluminum (Al chloride)/kg body weight for 17 d, in order to study the effects on superoxide dismutase (SOD) activities in the brain (cortex). No significant difference between control and treated animals was registered in the Cu/Zn and Mn SOD activities in the gray matter of the cortex. High Al levels were found in the plasma, the spleen, and the liver of the treated animals in comparison to the controls, but not in the cortex homogenates (gray matter). In addition, Al induced a significant decrease in food ingestion and weight gain.
Atienzar
F
F
University of Plymouth, Plymouth Environmental Research Centre, Biological Sciences, Devon, UK.
Desor
D
D
Burnel
D
D
Keller
J M
JM
Lehr
P
P
Vasseur
P
P
D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000097:blood / Q000494:pharmacology*; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D002712:Chlorides / Q000097:blood / Q000494:pharmacology*; D005247:Feeding Behavior / Q000187:drug effects; D008099:Liver / Q000378:metabolism; D008297:Male; D008854:Microscopy, Electron; D008928:Mitochondria / Q000201:enzymology; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism*; D014018:Tissue Distribution; D015430:Weight Gain / Q000187:drug effects
D017607:Aluminum Compounds; D002712:Chlorides; D000077410:Aluminum Chloride; D013482:Superoxide Dismutase