title: Activation of vitellogenin II gene expression by steroid hormones in the old Japanese quail.
abstract: Alterations in the basal transcription rates of eukaryotic genes are believed to involve the binding of trans-acting factor(s) with specific DNA sequences in the promoter. We show here two interrelated events for the VTGII gene of the old, non-egg laying Japanese quail: alterations in the structure of the chromatin encompassing the gene, and binding of trans-acting factors to the promoter of the gene. Estradiol/progesterone alone or together cause alterations in the conformation of the chromatin of the promoter region of the gene. This may allow free access of nuclear protein(s) to the cis-acting elements, ERE, PRE and NF1, in the promoter of the gene and cause activation of transcription.
authors.affiliation: Department of Zoology, Banaras Hindu University, Varanasi, India.
authors.forename: S
authors.initials: S
authors.lastname: Gupta
authors.forename: R
authors.initials: R
authors.lastname: Upadhyay
authors.forename: M S
authors.initials: MS
authors.lastname: Kanungo
mesh_terms: D000375:Aging; D000818:Animals; D003370:Coturnix; D003851:Deoxyribonucleases / Q000378:metabolism; D004742:Enhancer Elements, Genetic; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D009687:Nuclear Proteins / Q000737:chemistry / Q000378:metabolism; D011374:Progesterone / Q000494:pharmacology*; D011401:Promoter Regions, Genetic; D015183:Restriction Mapping; D015533:Transcriptional Activation; D014819:Vitellogenins / Q000096:biosynthesis / Q000235:genetics*
chemical_list: D009687:Nuclear Proteins; D014819:Vitellogenins; D011374:Progesterone; D004958:Estradiol; D003851:Deoxyribonucleases