Inhibition of lipid peroxidation mediated by indolizines.
Esters, ethers, carbonates and carbamates of 1-indolizinols and azaindolizinols exhibit a profound inhibition of lipid peroxidation in vitro. The antioxidants were prepared by cyclization of pyridines and diazines with diphenylcyclopropenone followed by introduction of the O-substituent.
Nasir
A I
AI
Department of Chemistry, University of Oslo, Norway.
Gundersen
L L
LL
Rise
F
F
Antonsen
O
O
Kristensen
T
T
Langhelle
B
B
Bast
A
A
Custers
I
I
Haenen
G R
GR
Wikström
H
H
D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D007212:Indolizines / Q000737:chemistry / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D010084:Oxidation-Reduction
D000975:Antioxidants; D007212:Indolizines