In vitro properties of ciprofloxacin suppositories formulated with glycerogelatin and theobroma oil bases.
Ciprofloxacin suppositories formulated with glycerogelatin approximately nd theobroma oil bases were evaluated for in vitro bioavailability in 0.01N sodium hydroxide (pH approximately 10) and in phosphate buffer (pE- approximately 7.8). The release of ciprofloxacin from the two bases under conditions which simulated the conditions in the rectum was assessed using isolated pig rectum. The release of ciprofloxacin was faster from theobroma oil base than from glycerogelatin base using 0.01N sodium hydroxide as the dissolution medium. The cumulative amount of ciprofloxacin released was markedly reduced from each of the two bases in the presence of isolated pig's rectum and in phosphate buffer.
Ofoefule
S I
SI
Department of Pharmaceutical Technology & Ind. Pharmacy, University of Nigeria, Nsukka, Enugu State, Nigeria.
Nwankwo
C
C
Chukwu
A
A
Orisakwe
O E
OE
D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000737:chemistry*; D002099:Cacao / Q000737:chemistry; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000737:chemistry*; D005079:Excipients; D005780:Gelatin; D005990:Glycerol; D009823:Ointment Bases; D010938:Plant Oils / Q000737:chemistry; D013488:Suppositories; D013552:Swine
D000890:Anti-Infective Agents; D005079:Excipients; D009823:Ointment Bases; D010938:Plant Oils; D013488:Suppositories; D002939:Ciprofloxacin; D005780:Gelatin; D005990:Glycerol