title: [Neurulational forms of the pathology of human nervous system].
abstract: 47 human embryos aged from 22 days to 6 weeks with various brain anomalies were studied. Space reconstruction of the brain organization is performed in 6 embryos. Neurulation anomalies analysis allowed to establish that human nervous system development is highly unstable between days 21 and 27 after fecundation when active change of the brain shape takes place and non-specific disturbance or delay of nervous cylinders closing results in the development of the nervous system embryonal pathologies. Various forms of the brain embryonal anomalies result from the three following variants of the neurulation disturbances; neurulation halt in the postneuropore zone leads to anomalies of the intermediate and median brain and occipital region of the head; neurulation disturbance in the caudal area of the nervous tube is the cause of spinal cord anomalies. The above anomalies are formed as a result of local neurulation disturbances which are the primary cause of the morphogenetic pathologies in the nervous system development. Therefore, it is justifiable to classify early embryonal anomalies of the nervous system according to their morphological origin and not by the final state of the fetus.
authors.affiliation: Research Institute of Human Morphology, Moscow.
authors.forename: S V
authors.initials: SV
authors.lastname: Savel'ev
mesh_terms: D006801:Humans; D009420:Nervous System / Q000196:embryology* / Q000473:pathology; D009422:Nervous System Diseases / Q000151:congenital; D009432:Neural Crest / Q000473:pathology*
vernacular_title: Neĭruliatsionnye formy patologii nervnoĭ sistemy cheloveka.