title: Novel phosphate mimetics for the design of non-peptidyl inhibitors of protein tyrosine phosphatases.
abstract: Benzylic alpha,alpha-difluorosulfonates, alpha,alpha-difluorotetrazoles, and alpha,alpha-difluorocarboxylates of type 5 and 6 were synthesized and examined as potential phosphate biosteres for PTP1B inhibition. The alpha,alpha-difluorosulfonates and alpha,alpha-difluorotetrazoles were found to be more effective inhibitors than the analogous compounds bearing the fluoromalonyl group, a phosphate biostere currently being used for PTP inhibition.
authors.affiliation: Department of Chemistry, University of Toronto, Mississauga, Ontario, Canada.
authors.forename: C C
authors.initials: CC
authors.lastname: Kotoris
authors.forename: M J
authors.initials: MJ
authors.lastname: Chen
authors.forename: S D
authors.initials: SD
authors.lastname: Taylor
mesh_terms: D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D017027:Protein Tyrosine Phosphatases