Studies of structure activity relationship of flavonoids for the anti-allergic actions.
The structure activity relationship of flavonoids for anti-allergic actions was studied by determining the IC50 values for the degranulation. The hexosaminidase release from RBL-2H3 cells (degranulation marker) was employed as an estimate for the anti-allergic actions. Among 22 flavonoid compounds tested, luteolin, apigenin, diosmetin, fisetin, and quercetin were found to be most active with IC50 values less than 10 microM.
Cheong
H
H
College of Pharmacy, Chonnam National University, Kwang-Ju, Korea.
Ryu
S Y
SY
Oak
M H
MH
Cheon
S H
SH
Yoo
G S
GS
Kim
K M
KM
D000818:Animals; D018926:Anti-Allergic Agents / Q000737:chemistry* / Q000494:pharmacology; D002392:Catechin / Q000494:pharmacology; D002460:Cell Line; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology*; D044948:Flavonols; D007529:Isoflavones / Q000494:pharmacology; D015394:Molecular Structure; D051381:Rats; D013329:Structure-Activity Relationship; D001619:beta-N-Acetylhexosaminidases / Q000378:metabolism
D018926:Anti-Allergic Agents; D005419:Flavonoids; D044948:Flavonols; D007529:Isoflavones; D002392:Catechin; D001619:beta-N-Acetylhexosaminidases