title: Synthesis and biological properties of new 1 beta-methylcarbapenems.
abstract: The synthesis and biological activity of the novel series of 1 beta-methylcarbapenems, 1 and 2 were described. Most compounds displayed high potent antibacterial activity. The best compound in this series, 2a (IH201; R2 = NH2) showed an excellent and a broad spectrum as well as high renal DHP-I stability. It also possessed good in vivo efficacy and high safety.
authors.affiliation: Medicinal Chemistry Research Center, Korea Institute of Science and Technology, Seoul, Korea.
authors.forename: K J
authors.initials: KJ
authors.lastname: Shin
authors.forename: K H
authors.initials: KH
authors.lastname: Yoo
authors.forename: D J
authors.initials: DJ
authors.lastname: Kim
authors.forename: S W
authors.initials: SW
authors.lastname: Park
authors.forename: B S
authors.initials: BS
authors.lastname: Ko
authors.forename: S J
authors.initials: SJ
authors.lastname: Lee
authors.forename: J D
authors.initials: JD
authors.lastname: Huh
authors.forename: S Y
authors.initials: SY
authors.lastname: Park
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D019540:Area Under Curve; D015780:Carbapenems / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D007928:Lethal Dose 50; D051379:Mice; D008826:Microbial Sensitivity Tests
chemical_list: D000890:Anti-Infective Agents; D015780:Carbapenems