title: SMC proteins and chromosome structure.
abstract: The structure of chromosomes is largely determined by chromosome-associated proteins. Members of the SMC (structural maintenance of chromosomes) family play an important role in both prokaryotic and eukaryotic chromosome structure and dynamics. SMC proteins are involved in chromosome condensation, sister-chromatid cohesion, sex-chromosome dosage compensation, genetic recombination and DNA repair. There have been major advances recently in understanding the function of SMC proteins--including the identification of biochemical activities of SMC-containing protein complexes and the realization that individual SMC proteins might link seemingly unrelated aspects of chromosomal metabolism.
authors.affiliation: NIH, NICHD, Laboratory of Molecular Embryology, Unit of Chromosome Structure and Function, Bethesda, MD 20892, USA. strunnik@box-s.nih.gov
authors.forename: A V
authors.initials: AV
authors.lastname: Strunnikov
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000737:chemistry / Q000502:physiology*; D002868:Chromosomal Proteins, Non-Histone; D004247:DNA / Q000096:biosynthesis; D004303:Dosage Compensation, Genetic; D005656:Fungal Proteins / Q000737:chemistry / Q000502:physiology*; D008938:Mitosis; D009687:Nuclear Proteins / Q000737:chemistry / Q000502:physiology*; D011487:Protein Conformation; D029701:Saccharomyces cerevisiae Proteins; D000098550:Structural Maintenance of Chromosome Protein 1
chemical_list: D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D005656:Fungal Proteins; D009687:Nuclear Proteins; C090455:SMC2 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D000098550:Structural Maintenance of Chromosome Protein 1; D004247:DNA