title: Syntheses of new modified Phe-Pro peptides. Use of proline replacements in potential HIV inhibitors.
abstract: The syntheses consisting of replacement of proline amino acid by a 3-pyrrolidinone ring in Phe-Pro analogues are described. Preliminary anti-HIV studies demonstrated the potential activity of this new class of compounds.
authors.affiliation: Laboratoire de Chimie Biomoléculaire, Faculté des Sciences de Luminy, Université de la Méditerranée, Marseille, France.
authors.forename: M
authors.initials: M
authors.lastname: Bouygues
authors.forename: M
authors.initials: M
authors.lastname: Medou
authors.forename: G
authors.initials: G
authors.lastname: Quéléver
authors.forename: J C
authors.initials: JC
authors.lastname: Chermann
authors.forename: M
authors.initials: M
authors.lastname: Camplo
authors.forename: J L
authors.initials: JL
authors.lastname: Kraus
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D004151:Dipeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D011392:Proline / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D019380:Anti-HIV Agents; D004151:Dipeptides; D011392:Proline