title: The synthesis and biological activity of a novel series of diazepine MMP inhibitors.
abstract: A novel series of diazepine-based hydroxamic acid inhibitors of MMP-1, MMP-9, and MMP-13 were prepared and evaluated both in vitro and in vivo.
authors.affiliation: Wyeth-Ayerst Research, Pearl River, NY 10965, USA.
authors.forename: J I
authors.initials: JI
authors.lastname: Levin
authors.forename: J F
authors.initials: JF
authors.lastname: DiJoseph
authors.forename: L M
authors.initials: LM
authors.lastname: Killar
authors.forename: A
authors.initials: A
authors.lastname: Sung
authors.forename: T
authors.initials: T
authors.lastname: Walter
authors.forename: M A
authors.initials: MA
authors.lastname: Sharr
authors.forename: C E
authors.initials: CE
authors.lastname: Roth
authors.forename: J S
authors.initials: JS
authors.lastname: Skotnicki
authors.forename: J D
authors.initials: JD
authors.lastname: Albright
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001381:Azepines / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D006877:Hydroxamic Acids / Q000138:chemical synthesis / Q000494:pharmacology; D020781:Matrix Metalloproteinase 1; D020780:Matrix Metalloproteinase 9; D061965:Matrix Metalloproteinase Inhibitors; D051379:Mice; D009930:Organic Chemicals; D011480:Protease Inhibitors / Q000494:pharmacology; D011719:Pyrazines; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D001381:Azepines; C097658:CGS 27023A; D004791:Enzyme Inhibitors; D006877:Hydroxamic Acids; D061965:Matrix Metalloproteinase Inhibitors; D009930:Organic Chemicals; D011480:Protease Inhibitors; D011719:Pyrazines; D013449:Sulfonamides; C113282:prinomastat; D020780:Matrix Metalloproteinase 9; D020781:Matrix Metalloproteinase 1