Angiogenesis and hypertension.
BACKGROUND
The formation of new blood vessels is an important process in embryonic development and in physiological repair processes. Abnormalities in blood vessel growth have been associated with various pathologies.
The basic observation underlying the hypothesis that essential hypertension is based on an impaired capacity for vascular growth is the nature of the structural alterations of microvascular beds in essential hypertension. Recent advances in understanding the molecular and cellular mechanisms of vascular growth suggest that the remodeling of individual vessels and vascular networks in hypertension may be a pathological variant of the formation of mature networks.
Genetic and fetal influences appear to have significant effects in determining impaired vascular development as an early cause of essential hypertension.
le Noble
F A
FA
Department of Pharmacology, Cardiovascular Research Institute Maastricht, Universiteit Maastricht, The Netherlands.
Stassen
F R
FR
Hacking
W J
WJ
Struijker Boudier
H A
HA
D000818:Animals; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D009389:Neovascularization, Pathologic / Q000503:physiopathology*