Therapeutic strategies based on immunological hypotheses of Alzheimer's disease.
There are several findings demonstrating the importance of inflammatory or immunological processes in the etiopathogenesis of Alzheimer's disease (AD). Several studies on nonsteroidal anti-inflammatory drugs (NSAID) give evidence for a therapeutic effect of these drugs in AD, among other the prospective double-blind placebo-controlled study on indomethacin, strongly support the therapeutic effect of these agents. Possibly also the therapeutic effects of propentofylline might be interpreted in the light of this theory.
Möller
H J
HJ
Psychiatric Hospital, Ludwig-Maximilians-University, Munich, Federal Republic of Germany.
D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000276:immunology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D018849:Controlled Clinical Trials as Topic; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use; D008297:Male; D018448:Models, Immunological; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D014970:Xanthines / Q000627:therapeutic use*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D018696:Neuroprotective Agents; D014970:Xanthines; C032114:propentofylline; D007213:Indomethacin