Amicrobial pustulosis of the folds. A cutaneous manifestation associated with connective tissue disease.
Amicrobial pustulosis (AP) is a recently defined entity associated with connective tissue diseases. Few cases have appeared in the literature. We report a case of AP coexisting with a systemic lupus erythematosus-scleroderma overlap syndrome and marked photosensitivity. The patient presented prominent pustular skin lesions and a few discoid lupus ones. No significant differences in the inflammatory infiltrate were found between the two clinical variants. The infiltrate consisted mainly of CD4+ lymphocytes and many neutrophils. CD1a+ dendritic cells were few in both epidermis and dermis. AP introduces a potential source of diagnostic confusion, but increasing experience of this syndrome will improve the awareness and diagnostic potential among dermatologists.
Stefanidou
M P
MP
Department of Dermatology, Division of Medicine, University of Heraklion, Greece.
Kanavaros
P E
PE
Stefanaki
K S
KS
Tosca
A D
AD
D005260:Female; D006801:Humans; D007402:Intertrigo / Q000150:complications / Q000473:pathology*; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000473:pathology; D008875:Middle Aged; D012595:Scleroderma, Systemic / Q000150:complications / Q000473:pathology; D012872:Skin Diseases, Vesiculobullous / Q000150:complications / Q000473:pathology*