title: Lung aeration and pulmonary gas exchange during lumbar epidural anaesthesia and in the lithotomy position in elderly patients.
abstract: We investigated a total of 36 subjects with a mean (SD) age of 65 (13) years, during baseline conditions (supine, before any anaesthesia), and then during one of the following protocols: (1) lithotomy positioning (n = 12), (2) epidural anaesthesia (n = 12), (3) general anaesthesia in the supine position (n = 12). Lung aeration, ventilation/perfusion matching, gas exchange and functional residual capacity were measured. Lung aeration was normal during baseline assessment with almost no regions with poor aeration and no substantial dependent densities. Shunt and perfusion of poorly ventilated regions were minor. Lithotomy positioning did not reduce functional residual capacity and did not affect aeration of the lung or ventilation/perfusion matching. Epidural anaesthesia, in general, had no effect on aeration, ventilation/perfusion matching or gas exchange, regardless of whether the patient was in the supine or lithotomy position. General anaesthesia, however, caused significant increases in poorly aerated lung regions and in dependent densities (interpreted as atelectasis). In conclusion, no or little impairment of lung aeration and ventilation/perfusion matching was caused by the lithotomy position and/or epidural anaesthesia, contrary to the effects seen during general anaesthesia. However, our findings also suggest that being overweight is a factor that may cause impairment of lung aeration.
authors.affiliation: Department of Anaesthesiology, University Hospital, Uppsala, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Reber
authors.forename: T
authors.initials: T
authors.lastname: Bein
authors.forename: M
authors.initials: M
authors.lastname: Högman
authors.forename: Z P
authors.initials: ZP
authors.lastname: Khan
authors.forename: S
authors.initials: S
authors.lastname: Nilsson
authors.forename: G
authors.initials: G
authors.lastname: Hedenstierna
mesh_terms: D000368:Aged; D000767:Anesthesia, Epidural; D000768:Anesthesia, General; D005652:Functional Residual Capacity; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000502:physiology*; D011187:Posture / Q000502:physiology*; D011659:Pulmonary Gas Exchange / Q000502:physiology*; D016683:Supine Position / Q000502:physiology; D014057:Tomography, X-Ray Computed