title: Myotonia associated with hyperadrenocorticism in two dogs.
abstract: Two dogs developed a disabling gait abnormality characterised by stiffness. The abnormality was consistent with a diagnosis of myotonia secondary to hyperadrenocorticism. The first dog had iatrogenic hyperadrenocorticism, and its signs improved substantially after corticosteroid administration was gradually withdrawn. The second had pituitary-dependent hyperadrenocorticism, but myotonic signs progressed despite effective mitotane therapy. Procainamide administration reduced the myotonic stiffness in the second case.
authors.affiliation: Department of Veterinary Clinical Sciences, University of Sydney, New South Wales.
authors.forename: G R
authors.initials: GR
authors.lastname: Swinney
authors.forename: S F
authors.initials: SF
authors.lastname: Foster
authors.forename: D B
authors.initials: DB
authors.lastname: Church
authors.forename: R
authors.initials: R
authors.lastname: Malik
mesh_terms: D000308:Adrenocortical Hyperfunction / Q000139:chemically induced / Q000150:complications / Q000662:veterinary*; D000818:Animals; D001623:Betamethasone / Q000009:adverse effects; D004283:Dog Diseases / Q000209:etiology*; D004285:Dogs; D004576:Electromyography / Q000662:veterinary; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects; D007049:Iatrogenic Disease / Q000662:veterinary; D008297:Male; D009222:Myotonia / Q000209:etiology / Q000662:veterinary*
chemical_list: D005938:Glucocorticoids; D001623:Betamethasone