title: Synthesis and in vitro cytotoxicity of C(20)(RS)-camptothecin analogues modified at both B (or A) and E ring.
abstract: A series of C(7) and C(20)-substituted camptothecin derivatives (12-14, 16-18) are prepared. Their syntheses and in vitro cytotoxicities are reported.
authors.affiliation: College of Pharmacy, Seoul National University, Korea.
authors.forename: S S
authors.initials: SS
authors.lastname: Jew
authors.forename: M G
authors.initials: MG
authors.lastname: Kim
authors.forename: H J
authors.initials: HJ
authors.lastname: Kim
authors.forename: E Y
authors.initials: EY
authors.lastname: Rho
authors.forename: H G
authors.initials: HG
authors.lastname: Park
authors.forename: J K
authors.initials: JK
authors.lastname: Kim
authors.forename: H J
authors.initials: HJ
authors.lastname: Han
authors.forename: H
authors.initials: H
authors.lastname: Lee
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D002166:Camptothecin