title: Na+-gated nonselective cation channel from lobster olfactory projection neurons.
abstract: Na+-gated nonselective cation channel from lobster olfactory projection neurons. J. Neurophysiol. 80: 3387-3391, 1998. A nonselective cation channel specifically activated by intracellular Na+ was identified in cell-free patches taken from cultured lobster olfactory projection neurons. Na+ reversibly activates the channel in a concentration-dependent manner, with a "half-effect" Na+ concentration of 76.4 mM at -60 mV. The conductance of the channel is 32 pS. The channel is permeable to both alkali metal (Li+ > Na+ > K+ > Rb+ > Cs+) and divalent (Ca2+ > Mn2+ > Sr2+ > Mg2+ > Ba2+ > Na+) cations. The presence of a channel with the ability to generate plateau potentials suggests that the channel may potentially contribute to oscillatory behavior in these olfactory interneurons.
authors.affiliation: Whitney Laboratory, University of Florida, St. Augustine, Florida 32086, USA.
authors.forename: A B
authors.initials: AB
authors.lastname: Zhainazarov
authors.forename: B W
authors.initials: BW
authors.lastname: Ache
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D004594:Electrophysiology; D066298:In Vitro Techniques; D007395:Interneurons / Q000187:drug effects / Q000502:physiology; D015640:Ion Channel Gating / Q000187:drug effects*; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D008121:Nephropidae / Q000502:physiology*; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology*; D018408:Patch-Clamp Techniques; D012903:Smell / Q000187:drug effects / Q000502:physiology*; D015222:Sodium Channels / Q000187:drug effects*; D013569:Synapses / Q000187:drug effects / Q000502:physiology
chemical_list: D015222:Sodium Channels