Synthesis of DNA analogues with novel carboxamidomethyl phosphonamide and glycinamide internucleoside linkages.
Thymidine oligonucleotide analogues with phosphodiester bonds fully substituted by carboxamidomethyl phosphonamide, or glycinamide linkages were synthesized on a solid support, and their hybridization properties toward DNA and RNA targets were determined by Tm analysis.
Efimov
V A
VA
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia. eva@ibch.siobc.ras.ru
Buryakova
A A
AA
Chakhmakhcheva
O G
OG
D004247:DNA / Q000737:chemistry*; D005998:Glycine / Q000031:analogs & derivatives*; D007202:Indicators and Reagents; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D063065:Organophosphonates; D013936:Thymidine / Q000031:analogs & derivatives* / Q000737:chemistry*
D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides; D063065:Organophosphonates; C027903:oligo (dT); C018556:glycine amide; D004247:DNA; D005998:Glycine; D013936:Thymidine