[The auto- and endocrine function of the adipose tissue. Significance for metabolic complications in obesity].
The present review discusses recent research showing adipose tissue to be highly metabolically active, producing and releasing many different bioactive compounds besides free fatty acids (FFA) such as tumor necrosis factor alpha (TNF alpha), leptin, acetylation stimulating protein (ASP), plasminogen activator inhibitor-1 (PAI-1), cholesterol ester transfer protein (CETP), prostaglandins and oestrogens. Most of these compounds have autocrine effects on the adipose cells and they are presumably involved in the physiological regulation of blood flow, growth and metabolism of the adipose tissue. When the adipose tissue becomes enlarged, as seen in association with obesity, it has now been shown that several of the compounds produced in the adipose tissue (TNF, PAI-1, CETP etc.) may be directly involved in the pathogenesis of some of the complications commonly seen in association with obesity such as insulin resistance, hypertension, enhanced thrombogenesis, and premature atherosclerosis.
Richelsen
B
B
Arhus Universitetshospital, Arhus Amtssygehus, medicinsk-endokrinologisk afdeling C. br@aas.auh.dk
Kristensen
K
K
Jensen
J D
JD
D000273:Adipose Tissue / Q000166:cytology / Q000378:metabolism* / Q000473:pathology; D000804:Angiotensin II / Q000378:metabolism; D000808:Angiotensinogen / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D006133:Growth Substances / Q000378:metabolism; D006801:Humans; D009765:Obesity / Q000150:complications / Q000209:etiology / Q000378:metabolism*; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism; D011453:Prostaglandins / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D005230:Fatty Acids, Nonesterified; D012739:Gonadal Steroid Hormones; D006133:Growth Substances; D017395:Plasminogen Activator Inhibitor 1; D011453:Prostaglandins; D014409:Tumor Necrosis Factor-alpha; D000808:Angiotensinogen; D000804:Angiotensin II
Fedtvaevets auto- og endokrine funktion. Betydning for de metaboliske komplikationer ved adipositas.