title: Glucose intolerance, cognitive impairment and Alzheimer's disease.
abstract: The literature on cognitive function and Alzheimer's disease in non-insulin-dependent diabetes, impaired glucose tolerance and hyperinsulinaemia are briefly summarized. Neuropsychological, epidemilogical and endocrine contributions are reviewed, with an emphasis on the insulin hypothesis as a potential pathophysiological mechanism for Alzheimer's disease.
authors.affiliation: Department of Neurology, University and University Hospital of Kuopio, Finland. matti.vanhanen@uku.fi
authors.forename: M
authors.initials: M
authors.lastname: Vanhanen
authors.forename: H
authors.initials: H
authors.lastname: Soininen
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology; D003072:Cognition Disorders / Q000175:diagnosis / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006946:Hyperinsulinism / Q000175:diagnosis / Q000503:physiopathology; D007328:Insulin / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests
chemical_list: D007328:Insulin