Free D- and L-amino acids in ventricular cerebrospinal fluid from Alzheimer and normal subjects.
Free D-Ser, D-Asp and total D-amino acids were significantly higher (p < 0.05) in Alzheimer (AD) ventricular CSF than in normal CSF. There was no significant difference in the total L-amino acids between AD and normal CSF, but L-Gln and L-His were significantly higher (p < 0.05) in AD-CSF. The higher concentrations of these D- and L-amino acids in AD ventricular CSF could reflect the degenerative process that occurs in Alzheimer's brain since ventricular CSF is the repository of amino acids from the brain.
Fisher
G
G
Department of Chemistry, Barry University, Miami Shores, Florida, USA.
Lorenzo
N
N
Abe
H
H
Fujita
E
E
Frey
W H
WH
Emory
C
C
Di Fiore
M M
MM
D' Aniello
A
A
D000544:Alzheimer Disease / Q000134:cerebrospinal fluid*; D000596:Amino Acids / Q000134:cerebrospinal fluid*; D006801:Humans
D000596:Amino Acids