title: Korundamine A, a novel HIV-inhibitory and antimalarial "hybrid" naphthylisoquinoline alkaloid heterodimer from Ancistrocladus korupensis.
abstract: A unique heterodimeric naphthylisoquinoline alkaloid, korundamine A (2), comprised of two different monomeric biaryl halves, has been isolated from the Cameroonian tropical liana Ancistrocladus korupensis. Korundamine A is the first "hybrid" dimer found in the Ancistrocladaceae; in vitro, it demonstrated anticytopathic activity against HIV-1 and antimalarial activity against Plasmodium falciparum.
authors.affiliation: Laboratory of Drug Discovery Research and Development, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
authors.forename: Y F
authors.initials: YF
authors.lastname: Hallock
authors.forename: J H
authors.initials: JH
authors.lastname: Cardellina
authors.forename: M
authors.initials: M
authors.lastname: Schäffer
authors.forename: G
authors.initials: G
authors.lastname: Bringmann
authors.forename: G
authors.initials: G
authors.lastname: François
authors.forename: M R
authors.initials: MR
authors.lastname: Boyd
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D019281:Dimerization; D015497:HIV-1 / Q000187:drug effects / Q000472:pathogenicity; D009682:Magnetic Resonance Spectroscopy; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010944:Plants / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D011804:Quinolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment
chemical_list: D019380:Anti-HIV Agents; D000962:Antimalarials; D009281:Naphthalenes; D011804:Quinolines; C116665:korundamine A