New cyclic peroxides from the Philippine sponge Plakinastrella sp.
Three new cyclic peroxides 5-7 and a new carboxylic acid ester 8 were isolated as minor metabolites from the hexane extract of a Plakinastrella species from the Philippines. The structures of compounds 5-8 were elucidated by interpretation of spectral data and by chemical interconversion, and the absolute stereochemistry of peroxide 6 was determined by application of Mosher's method to a derivative. Although the major compounds in the sponge showed activity against Candida albicans prior to decomposition, the minor metabolites 5-8 are essentially inactive.
Qureshi
A
A
Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093-0212, USA.
Salvá
J
J
Harper
M K
MK
Faulkner
D J
DJ
D000818:Animals; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010545:Peroxides / Q000302:isolation & purification* / Q000494:pharmacology; D010679:Philippines; D011161:Porifera / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured
D000935:Antifungal Agents; D010545:Peroxides