Potentialization of IL-2 effects on immune cells by oyster extract (JCOE) in normal and HIV-infected individuals.
Peripheral blood mononuclear cells (PBMCs) are physiologically activated by interleukin (IL)-2. We found that oyster extract (JCOE) currently used as a functional nutrient enhanced in vitro the IL-2 dependent activation as measured by cell count. 3H-thymidine uptake and up-regulation of a IL-2 receptor. In human immunodeficiency virus (HIV) seropositive individuals, this oyster extract-induced effect was marked in asymptomatic individuals with quasi-normal CD4 cell counts, but was weakly reflected in acquired immunodeficiency syndrome (AIDS) patients.
Achour
A
A
Université Pierre et Marie Curie, Laboratoire de Physiologie Cellulaire, Paris, France.
Lachgar
A
A
Astgen
A
A
Chams
V
V
Bizzini
B
B
Tapiero
H
H
Zagury
D
D
D000818:Animals; D018791:CD4 Lymphocyte Count; D002478:Cells, Cultured; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D010125:Ostreidae; D015375:Receptors, Interleukin-2 / Q000096:biosynthesis / Q000235:genetics; D011994:Recombinant Proteins / Q000494:pharmacology; D012016:Reference Values; D015854:Up-Regulation
D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D011994:Recombinant Proteins