Continuous venovenous rewarming: results from a juvenile animal model.
OBJECTIVE
To compare a standard and an experimental method of rewarming in 5-wk-old goats with induced moderate hypothermia.


METHODS
Hypothermia was induced in ten juvenile Nubian goats. Five goats were randomly assigned to be rewarmed using standard techniques, and five were assigned to the experimental rewarming technique of a modified continuous venovenous hemofiltration circuit.


METHODS
Animal research facility, Greenville Hospital System/Clemson University Biomedical Cooperative, Clemson, S.C.


METHODS
Ten 5-wk-old goats.


METHODS
Hypothermia to a body temperature of 29.4 degrees C was induced in the goats. Each of the control group of five goats was rewarmed using standard methods. Each of the experimental group of five goats was rewarmed using a modified continuous venovenous hemofiltration circuit.


RESULTS
At 2 hrs, the median temperature increase in the experimental group was 6.5 degrees C, compared with an increase of only 1.5 degrees C in the control group (p=.02). The mean increase in core body temperature over time (from baseline to 150 mins) was also significantly greater in the experimental group (p=.006).


CONCLUSIONS
The use of a modified continuous venovenous hemofiltration circuit for rewarming in a juvenile goat model after induction of moderate hypothermia is more effective than are standard methods.
Seigler
R S
RS
Pediatric Intensive Care Unit, The Children's Hospital of Greenville Hospital System, SC, USA.
Golding
E
E
Blackhurst
D W
DW
D000367:Age Factors; D000818:Animals; D001831:Body Temperature; D004195:Disease Models, Animal; D004867:Equipment Design; D005240:Feasibility Studies; D006041:Goats; D006440:Hemofiltration / Q000295:instrumentation / Q000379:methods*; D006358:Hot Temperature / Q000627:therapeutic use*; D007035:Hypothermia / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D011897:Random Allocation; D012720:Severity of Illness Index; D013997:Time Factors