title: Serine derived NK1 antagonists. 1: The effect of modifications to the serine substituents.
abstract: A series of novel serine derived NK1 antagonists is described. The effect of variations in the N-benzyl, O-benzyl and serine groups are used to define the elements which are necessary for binding.
authors.affiliation: Merck Sharp and Dohme Research Laboratories, Neuroscience Research Center, Harlow, Essex, U.K. jason_elliott@merck.com
authors.forename: J M
authors.initials: JM
authors.lastname: Elliott
authors.forename: M A
authors.initials: MA
authors.lastname: Cascieri
authors.forename: G
authors.initials: G
authors.lastname: Chicchi
authors.forename: S
authors.initials: S
authors.lastname: Davies
authors.forename: F J
authors.initials: FJ
authors.lastname: Kelleher
authors.forename: M
authors.initials: M
authors.lastname: Kurtz
authors.forename: T
authors.initials: T
authors.lastname: Ladduwahetty
authors.forename: R T
authors.initials: RT
authors.lastname: Lewis
authors.forename: A M
authors.initials: AM
authors.lastname: MacLeod
authors.forename: K J
authors.initials: KJ
authors.lastname: Merchant
authors.forename: S
authors.initials: S
authors.lastname: Sadowski
authors.forename: G I
authors.initials: GI
authors.lastname: Stevenson
mesh_terms: D064729:Neurokinin-1 Receptor Antagonists; D010880:Piperidines / Q000737:chemistry / Q000494:pharmacology*; D012694:Serine / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D064729:Neurokinin-1 Receptor Antagonists; D010880:Piperidines; D012694:Serine