The molecular genetics of post-transplantation lymphoproliferative disorders.
The post-transplantation lymphoproliferative disorders represent a significant clinical and diagnostic problem. However, these disorders also represent an important biological model for studying the development and progression of lymphoid neoplasia in immune deficiency. Accurate diagnosis and classification of these disorders requires correlative multiparametric analysis of the clinical behavior of the patient with the histopathological features, immunophenotype, clonal composition, and genetic alterations of the lymphoproliferative disorder. Such analyses should also assist in furthering our understanding of the pathogenesis of these disorders.
Knowles
D M
DM
Department of Pathology, Weill Medical College of Cornell University, New York, NY 10021, USA.
D015139:Blotting, Southern; D004268:DNA-Binding Proteins / Q000235:genetics; D004854:Herpesvirus 4, Human / Q000145:classification; D006651:Histocytochemistry; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000145:classification / Q000235:genetics* / Q000473:pathology / Q000821:virology; D009154:Mutation; D016377:Organ Transplantation / Q000009:adverse effects*; D011518:Proto-Oncogene Proteins / Q000235:genetics; D051560:Proto-Oncogene Proteins c-bcl-6; D014157:Transcription Factors / Q000235:genetics
D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; D051560:Proto-Oncogene Proteins c-bcl-6; D014157:Transcription Factors