title: Voltage-dependent ion channel formation by rigid rod-shaped polyols in planar lipid bilayers.
abstract: In this Letter, we describe the appearance of large, voltage-dependent currents in BLM induced by rigid rod-shaped polyols that function without charge and permanent dipole moment. The capacity of these symmetrical, nonpeptide models to form either short-living nanopores or small ion channels is shown to depend critically on the length of rigid-rod scaffold as well as the nature of the lateral side chains.
authors.affiliation: Department of Chemistry, Georgetown University, Washington, DC 20057, USA.
authors.forename: N
authors.initials: N
authors.lastname: Sakai
authors.forename: C
authors.initials: C
authors.lastname: Ni
authors.forename: S M
authors.initials: SM
authors.lastname: Bezrukov
authors.forename: S
authors.initials: S
authors.lastname: Matile
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004553:Electric Conductivity; D015640:Ion Channel Gating / Q000502:physiology; D007473:Ion Channels / Q000737:chemistry* / Q000502:physiology*; D008051:Lipid Bilayers / Q000737:chemistry*; D008968:Molecular Conformation; D011108:Polymers / Q000737:chemistry; D013402:Sugar Alcohols / Q000737:chemistry*
chemical_list: D007473:Ion Channels; D008051:Lipid Bilayers; D011108:Polymers; D013402:Sugar Alcohols