New generation dopaminergic agents. 2. Discovery of 3-OH-phenoxyethylamine and 3-OH-N1-phenylpiperazine dopaminergic templates.
Described in this report is a systematic study which led to the identification of two new dopamine D2 partial agonists (5 and 17). Phenols 5 and 17 represent prototypes of two new classes of D2 partial agonists as well as templates for the future design of novel dopaminergic agents.
Mewshaw
R E
RE
Global Chemical Sciences Department, Wyeth-Ayerst Research Laboratories, Princeton, New Jersey 08543-8000, USA.
Husbands
M
M
Gildersleeve
E S
ES
Webb
M B
MB
Shi
X
X
Mazandarani
H
H
Cockett
M I
MI
Ochalski
R
R
Brennan
J A
JA
Abou-Gharbia
M
M
Marquis
K
K
McGaughey
G B
GB
Coupet
J
J
Andree
T H
TH
D018491:Dopamine Agonists / Q000737:chemistry* / Q000494:pharmacology; D010636:Phenols / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D010879:Piperazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D017448:Receptors, Dopamine D2 / Q000819:agonists; D013329:Structure-Activity Relationship
C116737:3-(2-(benzylamino)ethoxy)phenol; C116738:4-benzyl-1-(3-hydroxyphenyl)piperzine; D018491:Dopamine Agonists; D010636:Phenols; D010879:Piperazines; D017448:Receptors, Dopamine D2