title: Triple helix stabilization properties of oligonucleotides containing 8-amino-2'-deoxyguanosine.
abstract: Analysis of the Hoogsteen base pairs of guanine and 8-aminoguanine with cytosine in the gase phase shows a strong stabilization of the 8-aminoguanine.cytosine base pair due to the formation of an extra H-bond. Melting profiles of oligonucleotides carrying 8-amino-2'-deoxyguanosine confirm the triple helix stabilization properties of 8-aminoguanine.
authors.affiliation: European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Güimil García
authors.forename: A
authors.initials: A
authors.lastname: Bachi
authors.forename: R
authors.initials: R
authors.lastname: Eritja
authors.forename: F J
authors.initials: FJ
authors.lastname: Luque
authors.forename: M
authors.initials: M
authors.lastname: Orozco
mesh_terms: D003849:Deoxyguanosine / Q000737:chemistry*; D004355:Drug Stability; D006147:Guanine / Q000031:analogs & derivatives* / Q000737:chemistry; D006860:Hydrogen Bonding; D009841:Oligonucleotides / Q000737:chemistry*
chemical_list: D009841:Oligonucleotides; C033495:8-aminoguanine; D006147:Guanine; D003849:Deoxyguanosine