[The value of detecting CVB-IgM antibodies in diagnosing viral myocarditis of children].
By using the indirect immunofluorescence assay and the tissue cells infected with coxackie virus Group B as antigen, the authors detected the antibodies type IgM to coxsackie virus Group B (CVB-IgM) of the sera of 105 children with viral myocarditis (VMC), 59 children with other diseases (COD) and 67 healthy children (HC). The results showed that in VMC, the genometric mean titre (GMT) of CVB-IgM in female (1:16.58) was higher than that in male (1:9.28, P < 0.05); not only in female, but also in male the GMT of VMC was higher than that of HC; also the GMT in female of VMC was higher than the GMT in female of COD, but no considerable difference existed between male of VMC and COD. Without sex distinction the GMT of HC was 0.289, its standard variance was 0.9335, the upper limit titre of normal range was 1:8.6. The authors took 1:10 as the positive criterion, the sensitivity of CVB-IgM in diagnosing VMC was 79.05%, the specialities of differentiating VMC from COD and HC were 42.3% and 91.04%, the consistancy rates of diagnosing VMC from COD and HC were 65.85% and 83.72% respectively.
Ouyang
F
F
Clinical Laboratory, Third Affiliated Hospital, Hunan Medical University, Changsha.
Peng
H
H
Wu
J
J
Pu
P
P
D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D003384:Coxsackievirus Infections / Q000175:diagnosis*; D029822:Enterovirus B, Human / Q000276:immunology*; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D009205:Myocarditis / Q000175:diagnosis / Q000821:virology*
D000914:Antibodies, Viral; D007075:Immunoglobulin M