title: [Reproducibility of histoprognostic grades of invasive breast cancer].
abstract: In the framework of the quality assurance of the pathologists involved in the screening campaign it was proposed to test the reproducibility of the classical SCARFF, BLOOM and RICHARDSON (SBR) grade and the ELSTON-ELLIS grade (E-E) mentioned in the recent European recommendations. Twenty-four cases of invasive carcinoma were analyzed by 21 pathologists. Sixty-eight per cent agreement was obtained for the SBR grade and 69% for the E-E grade in the first round and vice versa in the second round. The mean value of the kappa test was 0.54 with SBR and 0.53 with E-E. The differentiation of the carcinoma was found to be the most reliable index (kappa score greater than 0.5), followed by the mitotic index (kappa score = 0.39 for SBR and 0.36 for E-E), and the nuclear polymorphism obtained the lowest score (kappa score ranging from 0.33 to 0.38). In our hands, the use of the E-E grade did not improve the reproducibility particularly for the mitotic index. Our results suggest however that the reproducibility may be improved by training.
authors.affiliation: Unité d'Anatomie et de Cytologie Pathologiques, Institut Paoli-Calmettes, Marseille, France.
authors.forename: J
authors.initials: J
authors.lastname: Jacquemier
authors.forename: C
authors.initials: C
authors.lastname: Charpin
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008403:Mass Screening / Q000379:methods*; D009361:Neoplasm Invasiveness; D015588:Observer Variation; D011379:Prognosis; D011785:Quality Assurance, Health Care; D015203:Reproducibility of Results
vernacular_title: Reproductibilité des grades histopronostiques des carcinomes invasifs du sein.