title: Synthesis and comparative evaluation of two antiviral agents: beta-L-Fd4C and beta-D-Fd4C.
abstract: The synthesis of beta-D-Fd4C was achieved in a stereoselective fashion from D-xylose. The antiviral activity and cytotoxicity of beta-D-Fd4C was compared with that of beta-L-Fd4C and 3TC (Lamivudine). Of the three agents compared, beta-L-Fd4C was found to be the most potent antiviral agent.
authors.affiliation: Vion Pharmaceuticals, Inc., Four Science Park, New Haven, CT 06511, USA.
authors.forename: S H
authors.initials: SH
authors.lastname: Chen
authors.forename: S
authors.initials: S
authors.lastname: Lin
authors.forename: I
authors.initials: I
authors.lastname: King
authors.forename: T
authors.initials: T
authors.lastname: Spinka
authors.forename: G E
authors.initials: GE
authors.lastname: Dutschman
authors.forename: E A
authors.initials: EA
authors.lastname: Gullen
authors.forename: Y C
authors.initials: YC
authors.lastname: Cheng
authors.forename: T W
authors.initials: TW
authors.lastname: Doyle
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006678:HIV / Q000187:drug effects; D006515:Hepatitis B virus / Q000187:drug effects; D051379:Mice; D051381:Rats; D013237:Stereoisomerism; D016047:Zalcitabine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D016047:Zalcitabine; C099405:dexelvucitabine