Carbocyclic frenolicin analogues: novel anticoccidial agents.
Carbocyclic analogues of the antibacterial natural product frenolicin B have been synthesised. These analogues were active against parasitic protozoa of the genus Eimeria and represent a new series of anticoccidial agents. The synthesis of simplified analogues helped to define a possible pharmacophore for frenolicin.
Armer
R E
RE
Pfizer Central Research, Sandwich, Kent.
Dutton
C J
CJ
Fenner
B R
BR
Greenwood
S D
SD
Hall
K T
KT
Rudge
A J
AJ
D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D003048:Coccidiosis / Q000188:drug therapy*; D004539:Eimeria / Q000187:drug effects; D009285:Naphthoquinones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D000095622:Benzoisochromanequinones
D000981:Antiprotozoal Agents; D009285:Naphthoquinones; C018066:frenolicin B; D000095622:Benzoisochromanequinones