Possibilities of conveying a cationic drug in Carbomer hydrogels.
A drug with cationic characteristics such as procaine can be conveyed in a Carbomer hydrogel in two different ways: (i) in the form of salt in solution in the aqueous phase, and (ii) in the base form salified with the same polymer. Introduction of the drug into the hydrogel with different concentrations of polymer produced, in both cases, a reduction in viscosity in relation to drug concentration. The gels with procaine salified with the polymer showed greater viscosity. The drug release rate, in general, diminished with the increase in polymer concentration. Nevertheless, when this concentration was maintained, there was no variation in release rate when the viscosity produced as a consequence of drug concentration was changed. Gels with procaine salified with the carboxyvinylic polymer had a faster release rate than those with procaine in the hydrochloride form dissolved in the aqueous phase. These results have also been confirmed by a simulated absorption test.
Realdon
N
N
Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Padua, Italy. realdon@pdfar3.dsfarm.unipd.it
Ragazzi
E
E
Dal Zotto
M
M
Dalla Fini
G
G
D000180:Acrylic Resins; D001682:Biological Availability; D002412:Cations; D016503:Drug Delivery Systems; D006801:Humans; D020100:Hydrogels; D066298:In Vitro Techniques; D011343:Procaine / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D012212:Rheology; D014783:Viscosity
D000180:Acrylic Resins; D002412:Cations; D020100:Hydrogels; C006903:carbopol 940; D011343:Procaine