title: [Carbohydrate adaptive substance for prophylaxis of immune disorders and correction of dysbacterioses].
abstract: Effects of a new preparation, adaptokhit, on the intestinal microbiocenosis and some parameters of immune resistance were studied in Macaque rhesus during 13-day hypokinesia. Experimental animals were given adaptokhit as an alimentary supplement preventing dysbiotic consequences of the microecologic unbalance due to motor restraint. Results of the investigation showed certain distinctions in the intestinal microflora in the experimental and control animals as early as on day three of the experiment. Intestinal microflora of the experimental primates who daily consumed adaptokhit at 50 mg/kg of the body remained stable throughout the period of observation. In contrast, in their controls lactoflora was found to decrease in parallel to the growth of opportunistically pathogenic endobacteria including representatives of Proteus and Clostridia sp., and development of dysbacteriosis of categories II and III. Besides, in the experimental animals adaptokhit prevented decline in the proliferative activity of lymphocytes further into adaptation. Also, at the final stage of observation following canceling the preparation there were signs of normalization of the allergologic status of primates in the experimental group. Therefore, adaptokhit can be used as an alimentary supplement to strengthen the colony resistance of animals in extreme conditions.
authors.forename: G V
authors.initials: GV
authors.lastname: Vikha
authors.forename: N N
authors.initials: NN
authors.lastname: Liz'ko
authors.forename: V I
authors.initials: VI
authors.lastname: Korol'kov
authors.forename: M P
authors.initials: MP
authors.lastname: Rykova
authors.forename: D O
authors.initials: DO
authors.lastname: Meshkov
authors.forename: A A
authors.initials: AA
authors.lastname: Sukhno
authors.forename: O A
authors.initials: OA
authors.lastname: Poletaeva
authors.forename: V N
authors.initials: VN
authors.lastname: Frolov
authors.forename: N I
authors.initials: NI
authors.lastname: Bevz
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Gordeev
mesh_terms: D000818:Animals; D003013:Clostridium / Q000302:isolation & purification; D003015:Clostridium Infections / Q000188:drug therapy*; D004040:Dietary Carbohydrates / Q000627:therapeutic use*; D007154:Immune System Diseases / Q000276:immunology / Q000517:prevention & control*; D007410:Intestinal Diseases / Q000178:diet therapy* / Q000382:microbiology; D007422:Intestines / Q000382:microbiology; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000276:immunology; D008253:Macaca mulatta; D008297:Male; D009844:Oligosaccharides / Q000627:therapeutic use*; D011511:Proteus / Q000302:isolation & purification; D011512:Proteus Infections / Q000188:drug therapy*
chemical_list: D004040:Dietary Carbohydrates; D009844:Oligosaccharides
vernacular_title: Uglevodnyĭ adaptogen dlia profilaktiki immunnykh rasstroĭstv i korrektsii disbakteriozov.