title: Synthesis of praziquantel derivatives and their in vitro activity against adult Clonorchis sinensis.
abstract: Several praziquantel derivatives have been prepared by the acylation of compound 5, and examined on their biological activity in vitro a against adult Clonorchis sinensis collected from rabbits infected with metacercariae which was isolated from Pseudorasbora parva, a second intermediate host, captured in Nakdong river in Korea.
authors.affiliation: Division of Applied Science, Korea Institute of Science & Technology, Seoul, Korea.
authors.forename: C S
authors.initials: CS
authors.lastname: Kim
authors.forename: D Y
authors.initials: DY
authors.lastname: Min
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis / Q000494:pharmacology*; D003004:Clonorchis sinensis / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D011223:Praziquantel / Q000031:analogs & derivatives* / Q000494:pharmacology*; D011817:Rabbits / Q000469:parasitology
chemical_list: D000871:Anthelmintics; D011223:Praziquantel