Effect of Fenoterol on PAF-induced lung edema in isolated and perfused rabbit lungs.
We have studied the effects of fenoterol on PAF-induced response in pulmonary circulation. We used 28 isolated and perfused rabbit lungs preparations: eight control preparations (CP), four vehicles preparations (VP), eight PAF preparations (PP) with two doses of PAF, one called low dose (LD = 0.5 microg/kg of weight) and the other high dose (HD = 1 microg/kg of weight) and eight Fenoterol preparations (FP) which we administered 0.05 mg of Fenoterol for 15 min, followed by a LD and HD of PAF. FP prevented elevation of pulmonary artery pressure (Ppa) as compared to PP, at LD of PAF: 12.615 (CI 95%: 8.57-20.885) versus 83.705 (CI 95%: 50.55-114.3) cm of water; and at HD of PAF: 19.38 (CI 95%: 11.235-28.94) versus 205.1 (CI 95%: 141.3-271) cm of water respectively. FP prevented the increase in fluid filtration rate (FFR) observed in PP at both doses of PAF LD: 0.765 (CI 95%: 0.07-3.385) versus 0.01 (CI 95%: -0.05-0.005) g/min; HD: 5.515 (CI 95%: 2.425-8.865) versus 0.03 (CI 95%: 0-0.33) g/min. Our results suggest that PAF has a vasoconstrictor effect that produces lung edema and this effect is inhibited by fenoterol.
Pesce
L
L
Unidad de Fisiologia Respiratoria, Instituto de Medicina Experimental, Facultad de Medicina, Escuela Luis Razetti, Universidad Central de Venezuela, Caracas.
Tristano
S
S
Friedman
E
E
Comellas
A
A
Marcano
H
H
Sanchez de León
R
R
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D005280:Fenoterol / Q000494:pharmacology*; D066298:In Vitro Techniques; D010477:Perfusion; D010972:Platelet Activating Factor; D011652:Pulmonary Circulation / Q000187:drug effects; D011654:Pulmonary Edema / Q000139:chemically induced* / Q000503:physiopathology*; D011817:Rabbits
D000318:Adrenergic beta-Agonists; D010972:Platelet Activating Factor; D005280:Fenoterol