Neuronorm is a potent and water soluble neurokinin A receptor antagonist.
We report here the synthesis and preliminary pharmacological characterization of a novel water soluble Neurokinin A receptor antagonist named Neuronorm. The synthesis was achieved in high yield by a combination of classical peptide synthesis methodologies, in both solution and solid phase. The pharmacological properties as neurokinin A receptor antagonist were assessed in in vitro experiments on rat vas deferens and guinea pig trachea, and were compared to those of MEN10627.
Lombardi
A
A
Centro Interuniveristario di Ricerca su Peptidi Bioattivi, Università di Napoli Federico II, Italy.
D'Agostino
B
B
Filippelli
A
A
Pedone
C
C
Matera
M G
MG
Falciani
M
M
De Rosa
M
M
Rossi
F
F
Pavone
V
V
D000818:Animals; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D018041:Receptors, Neurokinin-2 / Q000037:antagonists & inhibitors*; D014132:Trachea / Q000187:drug effects; D014649:Vas Deferens / Q000187:drug effects
D010456:Peptides, Cyclic; D018041:Receptors, Neurokinin-2; C116640:neuronorm; C090951:MEN 10627