Serine derived NK1 antagonists. 2: A pharmacophore model for arylsulfonamide binding.
Modifications to the spirocyclic aryl sulfonamide portion of serine derived NK1 antagonists allow a partial pharmacophore model to be developed.
Elliott
J M
JM
Merck Sharp and Dohme Research Laboratories, Neuroscience Research Center, Harlow, Essex, U.K.
Broughton
H
H
Cascieri
M A
MA
Chicchi
G
G
Huscroft
I T
IT
Kurtz
M
M
MacLeod
A M
AM
Sadowski
S
S
Stevenson
G I
GI
D008956:Models, Chemical; D064729:Neurokinin-1 Receptor Antagonists; D010880:Piperidines / Q000737:chemistry* / Q000494:pharmacology; D018040:Receptors, Neurokinin-1 / Q000378:metabolism; D012694:Serine / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000378:metabolism*
D064729:Neurokinin-1 Receptor Antagonists; D010880:Piperidines; D018040:Receptors, Neurokinin-1; D013449:Sulfonamides; D012694:Serine