The -491 A/T polymorphism in the regulatory region of the apolipoprotein E gene and early-onset Alzheimer's disease.
The -491 polymorphism in the promoter region of the apolipoprotein E gene (APOE) has been suggested to be associated with increased risk for Alzheimer's disease (AD) independent of APOE status. We studied the association between the -491 polymorphism and risk for early-onset Alzheimer's disease in 99 Dutch and 78 Spanish patients. In patients with early-onset AD, we found no consistent relationship with a single allele of the -491 polymorphism. Linkage disequilibrium between the polymorphism and the APOE gene was found which most likely might explain the inconsistent findings.
Roks
G
G
Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands.
Cruts
M
M
Bullido
M J
MJ
Backhovens
H
H
Artiga
M J
MJ
Hofman
A
A
Valdivieso
F
F
Van Broeckhoven
C
C
Van Duijn
C M
CM
D017668:Age of Onset; D000483:Alleles; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics; D005787:Gene Frequency; D008040:Genetic Linkage; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008875:Middle Aged; D017354:Point Mutation; D011110:Polymorphism, Genetic; D012045:Regulatory Sequences, Nucleic Acid
D001057:Apolipoproteins E