title: Potentialization of IL-2 effects on immune cells by oyster extract (JCOE) in normal and HIV-infected individuals.
abstract: Peripheral blood mononuclear cells (PBMCs) are physiologically activated by interleukin (IL)-2. We found that oyster extract (JCOE) currently used as a functional nutrient enhanced in vitro the IL-2 dependent activation as measured by cell count. 3H-thymidine uptake and up-regulation of a IL-2 receptor. In human immunodeficiency virus (HIV) seropositive individuals, this oyster extract-induced effect was marked in asymptomatic individuals with quasi-normal CD4 cell counts, but was weakly reflected in acquired immunodeficiency syndrome (AIDS) patients.
authors.affiliation: Université Pierre et Marie Curie, Laboratoire de Physiologie Cellulaire, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Achour
authors.forename: A
authors.initials: A
authors.lastname: Lachgar
authors.forename: A
authors.initials: A
authors.lastname: Astgen
authors.forename: V
authors.initials: V
authors.lastname: Chams
authors.forename: B
authors.initials: B
authors.lastname: Bizzini
authors.forename: H
authors.initials: H
authors.lastname: Tapiero
authors.forename: D
authors.initials: D
authors.lastname: Zagury
mesh_terms: D000818:Animals; D018791:CD4 Lymphocyte Count; D002478:Cells, Cultured; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D010125:Ostreidae; D015375:Receptors, Interleukin-2 / Q000096:biosynthesis / Q000235:genetics; D011994:Recombinant Proteins / Q000494:pharmacology; D012016:Reference Values; D015854:Up-Regulation
chemical_list: D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D011994:Recombinant Proteins