[Effect of puerarin on plasma endothelin, renin activity and angiotensin II in patients with acute myocardial infarction].
OBJECTIVE
To study the changes of endothelin (ET), renin activity (RA) and angiotensin II (AT-II) before and after puerarin treatment in patients with acute myocardial infarction (AMI).


METHODS
Forty-three patients with AMI were divided into two groups, and were given puerarin and glucose-insulin-kalium (GIK) treatment respectively. Plasma ET, RA and AT-II were measured by radioimmunoassay (RIA) before and after treatment in different phases.


RESULTS
It showed that plasma ET and RA, AT-II levels in AMI were higher than those in control group (P < 0.01). ET level was conversely correlated with RA and AT-II (P < 0.01). After treatment with puerarin, plasma levels of ET, RA and AT-II were recovered to normal in 3 days, but these data recovered to nearly normal until 7-14 days in group with GIK treatment.


CONCLUSIONS
Puerarin might play an important role in regulating the imbalance of ET, RA and AT-II of patients with AMI.
Li
S M
SM
Department of Cardiology, Second Teaching Hospital, Bethune University of Medical Sciences, Changchun.
Liu
B
B
Chen
H F
HF
D000368:Aged; D000804:Angiotensin II / Q000097:blood; D016232:Endothelins / Q000097:blood*; D005260:Female; D006801:Humans; D007529:Isoflavones / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology / Q000627:therapeutic use*
D016232:Endothelins; D007529:Isoflavones; D014665:Vasodilator Agents; D000804:Angiotensin II; D012083:Renin; C033607:puerarin