Pharmacokinetic aspects of measurement of glomerular filtration rate in the dog: a review.
Glomerular filtration rate (GFR) is estimated by means of clearance, defined as the volume of plasma that has been cleared of a particular substance per unit time. Glomerular filtration rate may be estimated by measuring the renal clearance of a filtration marker using data from both urine and plasma or by plasma clearance using only plasma data. Several alternative pharmacokinetic models are used for the calculation of clearance using various filtration markers with slightly different pharmacokinetic properties. The purpose of this article is to discuss how the choice of marker and pharmacokinetic model may influence estimated GFR values and to elucidate commonly used methods and reported GFR values in the dog.
Heiene
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R
School of Veterinary Medicine, University of California, Davis. Reidun.Heiene@veths.no
Moe
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L
D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000652:urine; D003404:Creatinine / Q000097:blood / Q000493:pharmacokinetics; D004285:Dogs / Q000378:metabolism*; D004492:Edetic Acid / Q000097:blood / Q000493:pharmacokinetics; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology / Q000662:veterinary*; D007444:Inulin / Q000097:blood / Q000493:pharmacokinetics; D007483:Iothalamic Acid / Q000493:pharmacokinetics; D007668:Kidney / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D004369:Pentetic Acid / Q000097:blood / Q000493:pharmacokinetics; D012727:Sex Characteristics
D015415:Biomarkers; D007483:Iothalamic Acid; D004369:Pentetic Acid; D007444:Inulin; D004492:Edetic Acid; D003404:Creatinine