title: Macromolecular cytosolic delivery: cell membranes as the primary obstacle.
abstract: The "evolution" of a thing, a custom, an organ is thus by no means its progressus toward a goal, even less a logical progressus by the shortest route and with the least expenditure of force, but a succession of more or less profound, mutually independent processes of subduing, plus the resistances they encounter, the attempts at transformation for the purpose of defense and reaction, and the results of successful counteractions. The form is fluid, but the "meaning" is even more so.
authors.affiliation: Pharmaceutics Division, College of Pharmacy, University of Michigan, Ann Arbor 48019-1065, USA.
authors.forename: G M
authors.initials: GM
authors.lastname: Larson
authors.forename: K D
authors.initials: KD
authors.lastname: Lee
mesh_terms: D001419:Bacteria / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism*; D016503:Drug Delivery Systems; D018390:Gene Targeting; D005822:Genetic Vectors; D006801:Humans; D046911:Macromolecular Substances; D014780:Viruses / Q000378:metabolism
chemical_list: D046911:Macromolecular Substances