Combinatorial chemistry: from peptides and peptidomimetics to small organic and heterocyclic compounds.
Modified dipeptides have been used successfully for the generation of a variety of small organic and heterocyclic combinatorial libraries, including linear urea, polyamine, hydantoin, thiohydantoin, cyclic urea, cyclic thiourea and bicyclic guanidine. The synthesis and screening results for a number of these libraries are described. The solid phase synthesis of heterocyclic compounds such as diazepine and thiomorpholinone are also described.
Nefzi
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A
Torrey Pines Institute for Molecular Studies, San Diego, CA 92121, USA.
Dooley
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C
Ostresh
J M
JM
Houghten
R A
RA
D002625:Chemistry, Organic / Q000379:methods*; D019992:Databases as Topic; D004151:Dipeptides / Q000138:chemical synthesis* / Q000737:chemistry; D015195:Drug Design; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D008968:Molecular Conformation; D015394:Molecular Structure; D019151:Peptide Library; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D011487:Protein Conformation; D013329:Structure-Activity Relationship
D004151:Dipeptides; D006571:Heterocyclic Compounds; D007202:Indicators and Reagents; D019151:Peptide Library; D010455:Peptides