title: Ventilation and perfusion imaging by electrical impedance tomography: a comparison with radionuclide scanning.
abstract: Electrical impedance tomography (EIT) is a technique that makes it possible to measure ventilation and pulmonary perfusion in a volume that approximates to a 2D plane. The possibility of using EIT for measuring the left-right division of ventilation and perfusion was compared with that of radionuclide imaging. Following routine ventilation (81mKr) and perfusion scanning (99mTc-MAA), EIT measurements were performed at the third and the sixth intercostal level in 14 patients with lung cancer. A correlation (r = 0.98, p < 0.005) between the left-right division for the ventilation measured with EIT and that with 81mKr was found. For the left-right division of pulmonary perfusion a correlation of 0.95 (p < 0.005) was found between the two methods. The reliability coefficient (RC) was calculated for estimating the left-right division with EIT. The RC for the ventilation measurements was 94% and 96% for the perfusion measurements. The correlation analysis for reproducibility of the EIT measurements was 0.95 (p < 0.001) for the ventilation and 0.93 (p < 0.001) for the perfusion measurements. In conclusion, EIT can be regarded as a promising technique to estimate the left-right division of pulmonary perfusion and ventilation.
authors.affiliation: Department of Pulmonary Medicine, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands.
authors.forename: P W
authors.initials: PW
authors.lastname: Kunst
authors.forename: A
authors.initials: A
authors.lastname: Vonk Noordegraaf
authors.forename: O S
authors.initials: OS
authors.lastname: Hoekstra
authors.forename: P E
authors.initials: PE
authors.lastname: Postmus
authors.forename: P M
authors.initials: PM
authors.lastname: de Vries
mesh_terms: D000328:Adult; D000368:Aged; D017097:Electric Impedance; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D013668:Technetium Tc 99m Aggregated Albumin; D014054:Tomography / Q000295:instrumentation*; D014692:Ventilation-Perfusion Ratio
chemical_list: D019275:Radiopharmaceuticals; D013668:Technetium Tc 99m Aggregated Albumin