Poly (ADP-ribose) polymerase, a potential target for drugs: Part II. Regulation of differentiation by the poly ADP-ribose system.
It is shown that eukaryotic differentiation is specifically sensitive to pADPRT regulation in Trypanosomna, Leishmania and Mytilus models. There is powerful inhibition of early differentiation without cell toxicity by pADPRT ligands.
Kun
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Octamer, Inc, CA 94710, USA.
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D006801:Humans; D007891:Leishmania / Q000201:enzymology; D008024:Ligands; D049880:Mytilus edulis / Q000201:enzymology; D011065:Poly(ADP-ribose) Polymerases / Q000235:genetics / Q000378:metabolism*; D015800:Protozoan Proteins / Q000235:genetics / Q000378:metabolism; D014349:Trypanosoma cruzi / Q000201:enzymology
D008024:Ligands; D015800:Protozoan Proteins; D011065:Poly(ADP-ribose) Polymerases