Intracellular receptors for activated C-kinase in the postmortem human brain: no alteration in Alzheimer disease.
Previous studies have identified a 36-kDa protein that has the properties of an intracellular receptor for the activated C-kinase (RACK1). In the present investigation we quantified levels of RACK1 protein in brains from patients with Alzheimer disease (AD) and age-matched controls. Western analysis using a specific antibody showed that the protein levels for RACK1 were not significantly different in AD brains than in controls, indicating that RACK1 is preserved in AD.
Shimohama
S
S
Department of Neurology, Faculty of Medicine, Kyoto University, Japan.
Kamiya
S
S
Taniguchi
T
T
Kimura
J
J
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D010455:Peptides / Q000032:analysis*; D011493:Protein Kinase C / Q000032:analysis*; D000075370:Receptors for Activated C Kinase; D012016:Reference Values
D010455:Peptides; D000075370:Receptors for Activated C Kinase; C070301:peptide I; D011493:Protein Kinase C