title: The use of particle characteristics to elucidate mix homogeneity in binary powder blends.
abstract: A series of binary powder blends comprising microcrystalline cellulose (Avicel PH101), alpha-lactose monohydrate, or anhydrous theophylline were prepared in order to investigate the ability of particle-characteristics measurements to express the homogeneity of the resulting mixture. It is postulated that fundamental physical characteristics, such as particle-specific surface area, true density, and size distribution, can be used to quantitatively ascertain mix homogeneity in routine pharmaceutical blending operations.
authors.affiliation: Laboratoire Pharmacie Galénique, Faculté de Pharmacie, Université de Limoges, France.
authors.forename: M G
authors.initials: MG
authors.lastname: Vachon
authors.forename: D
authors.initials: D
authors.lastname: Chulia
mesh_terms: D002482:Cellulose / Q000737:chemistry*; D007785:Lactose / Q000737:chemistry*; D010316:Particle Size; D011208:Powders / Q000737:chemistry; D013499:Surface Properties; D013806:Theophylline / Q000737:chemistry*
chemical_list: D011208:Powders; D002482:Cellulose; D013806:Theophylline; D007785:Lactose