title: Recognition of 2'-deoxyisoguanosine triphosphate by HIV-1 reverse transcriptase and mammalian cellular DNA polymerases.
abstract: HIV-1 reverse transcriptase (RT) incorporates 2'-deoxyisoguanosine triphosphate (d-isoGTP) opposite thymidine (T) in a DNA template and opposite uracil (U) in an RNA template about 10 times more efficiently than the eukaryotic DNA polymerase alpha, both in the absence and presence of dATP.
authors.affiliation: Department of Chemistry, ETH Zürich, Universitätstr, Switzerland. michael.lutz@pharma.novartis.com
authors.forename: M J
authors.initials: MJ
authors.lastname: Lutz
authors.forename: J
authors.initials: J
authors.lastname: Horlacher
authors.forename: S A
authors.initials: SA
authors.lastname: Benner
mesh_terms: D000241:Adenosine; D001483:Base Sequence; D004247:DNA; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D006151:Guanosine / Q000737:chemistry / Q000378:metabolism*; D054303:HIV Reverse Transcriptase / Q000378:metabolism*; D013379:Substrate Specificity; D013698:Templates, Genetic
chemical_list: D006151:Guanosine; C008184:isoguanosine; D004247:DNA; D054303:HIV Reverse Transcriptase; D004259:DNA-Directed DNA Polymerase; D000241:Adenosine