Behavioral and neurobiological effects of estrogen replacement therapy and a history of triphasic oral contraceptive exposure.
The effects of contraceptive steroids and estrogen replacement therapy on behavior and neuroendocrine function were evaluated in adult female cynomolgus monkeys. During the 'premenopausal' phase of the experiment, the animals were assigned to either treatment with a triphasic oral contraceptive (OC) for 24 months or the untreated control group. The monkeys were then ovariectomized and half of each of the premenopausal groups were randomly assigned to either treatment with conjugated equine estrogens (ERT) or the untreated control group for 12 months (the 'postmenopausal' phase). All evaluations were completed during the postmenopausal phase of the experiment. Both types of exogenous steroid treatments appeared to increase cardiovascular and hypothalamic-pituitary-adrenal responses to stress in socially dominant but not socially subordinate females. A history of triphasic OC administration increased contact aggression received, and reduced the prolactin response to fenfluramine, suggesting reduced serotonergic activity, for at least a year following the cessation of triphasic OC treatment.
Shively
C A
CA
Department of Pathology (Comparative Medicine), Wake Forest University School of Medicine, Winston-Salem, NC 27157-1040, USA.
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000374:Aggression / Q000187:drug effects*; D000818:Animals; D001143:Arousal / Q000187:drug effects*; D003279:Contraceptives, Oral, Sequential / Q000494:pharmacology*; D004291:Dominance-Subordination; D015914:Estrogen Replacement Therapy; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006854:Hydrocortisone / Q000097:blood; D008252:Macaca fascicularis; D008593:Menopause / Q000187:drug effects*; D012919:Social Behavior
D003279:Contraceptives, Oral, Sequential; D000324:Adrenocorticotropic Hormone; D013006:Growth Hormone; D006854:Hydrocortisone