Figurate purpuric eruptions on the trunk: acetaminophen-induced rashes.
A 23-year-old man had recurrent erythematous purpuric patches in a transverse-linear arrangement on his back and arms. One week prior to a recent episode, he took acetaminophen for 3 days. Four months earlier, he developed the same purpuric lesions at/around the same anatomical site when he took acetaminophen for pain-relief. A biopsy specimen showed capillaritis and extravasation of erythrocytes in the papillary dermis. A provocation test with acetaminophen confirmed these lesions as drug-induced rashes. The uncommon topographic and morphologic features of the purpuric lesion in this patient might be considered as an unusual expression of pigmented purpuric dermatosis caused by acetaminophen.
Kwon
S J
SJ
Department of Dermatology, Hanyang University College of Medicine, Seoul, South Korea.
Lee
C W
CW
D000082:Acetaminophen / Q000009:adverse effects* / Q000627:therapeutic use; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects* / Q000627:therapeutic use; D001707:Biopsy, Needle; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D005076:Exanthema / Q000139:chemically induced* / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000188:drug therapy; D011693:Purpura / Q000139:chemically induced / Q000473:pathology
D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen