[Characterization of the adaptive response to the action of gamma-rays, induced by low doses of 14C in Chinese hamster fibroblasts].
It has been studied the correlation of the mitotic activity of the chromosome aberrations and apoptosis, in the V-79 cells pre-exposure to an adapting dose of ionizing radiation from 14C-thymidine prior to an acute challenge dose of gamma-rays. In spite of that the incubation of the cells with isotope increased of the yield of the chromosome aberrations, but the cells became more resistant to following gamma-irradiation. Increasing the adaptive dose of the 14C on degree didn't influence on the present of the adaptive response. However, using concentrations of the 14C damaged metaphase/anaphase transition and cells blocked in this check-point by apoptotic death. The results suggest, that the cellular selection has been involved in 14C-induced adaptive response, estimated by level of asymmetric chromosome aberrations in V-79 cells.
Gilliano
N Ia
NIa
Petersburg Nuclear Physics Institute, Russian Academy of Science, Gatchina.
Bol'shakova
O I
OI
Lavrova
G A
GA
Konevega
L V
LV
Bikineeva
E G
EG
Noskin
L A
LA
D000222:Adaptation, Physiological / Q000528:radiation effects*; D000705:Anaphase / Q000528:radiation effects; D000818:Animals; D002250:Carbon Radioisotopes; D002460:Cell Line; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus; D005347:Fibroblasts / Q000528:radiation effects*; D005720:Gamma Rays; D008677:Metaphase / Q000528:radiation effects; D008938:Mitosis / Q000528:radiation effects
D002250:Carbon Radioisotopes
Kharakteristika adaptivnogo otveta k deĭstviiu gamma-lucheĭ, indutsirovannogo malymi dozami 14C v fibroblastakh kitaĭskogo khomiachka.