Clinical experience with Donepezil (Aricept) in the UK.
Experience of the use of Donepezil (Aricept) in the UK since licensing is discussed. The results of a 30 week double blind parallel group study in the US of Donepezil 5 or 10 mg versus placebo show statistically significant improvements in cognitive and clinical global assessments. Beneficial effects were demonstrated in the absence of significant adverse effects on physical or laboratory values. The guidelines for use adopted in the UK are discussed with the emphasis on identifying non-cognitive behaviours, as significant improvements in these have been found and often have more impact on quality of life than cognitive improvements alone.
Wilkinson
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Thornhill Research Unit, University of Southampton, United Kingdom.
D000544:Alzheimer Disease / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D002985:Clinical Protocols; D000077265:Donepezil; D004311:Double-Blind Method; D006801:Humans; D007189:Indans / Q000627:therapeutic use*; D008009:Licensure, Pharmacy; D018697:Nootropic Agents / Q000627:therapeutic use*; D018579:Patient Selection; D010880:Piperidines / Q000627:therapeutic use*; D006113:United Kingdom
D007189:Indans; D018697:Nootropic Agents; D010880:Piperidines; D000077265:Donepezil