Pure cutaneous relapsing langerhans cell histiocytosis in an adult.
The histiocytic syndromes represent a group of rare diseases characterized by the proliferation of the mononuclear phagocyte system cells. We report a case of recurrent class I histiocytosis with exclusive cutaneous localization in an adult. Our patient had a 3 cm ulcerated nodule located on the right cheek. Subsequently, new lesions appeared, all having the same clinical evolution characterized by spontaneous resolution with scarring. After a five year follow up no more lesions were observed. The histopathological examination, immunohistochemical profile and electron microscopy of the lesions indicated Langerhans cell histiocytosis.
Baldo
A
A
Department of Dermatology, Federico II University of Naples, via Pansini 5, 80131 Naples, Italy. baldo@unina.it
Vitiello
A
A
Argenziano
G
G
Ferrara
G
G
Delfino
M
M
D001707:Biopsy, Needle; D002467:Cell Nucleus / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D005148:Facial Dermatoses / Q000175:diagnosis*; D006646:Histiocytosis, Langerhans-Cell / Q000473:pathology*; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D012008:Recurrence; D012075:Remission, Spontaneous; D012867:Skin / Q000473:pathology*