title: Formation, properties and antimicrobial activities of cotton xanthate-Cu(II)-homosulfamine complex.
abstract: To develop a cotton derivatives with prolonged antimicrobial activities, homosulfamine (Hs) was coupled to cotton xanthate (CX) via chelate bond in the presence of Cu(II) ion by one- and two-bath processes. In one-bath process, CX was treated with Cu(II)-Hs solution. In two-bath process, CX was treated with Cu(II) ion solution to produce CX-Cu(II) complex, which was isolated and treated in turn with Hs solution. Effects of concentration, Cu(II)/Hs ratio, and pH on the binding of Hs were investigated at 10 degrees C. In one-bath process, binding of Hs took place readily with optimum pH around 5-6. The amount of binding increased to give a maximum within 5 min and decreased slowly to establish an equilibrium within an hour. In two-bath process, binding of Hs was much lower than that of one-bath process. Release of Hs from CX-Cu(II)-Hs was investigated by batch and flow method. Antimicrobial activities of CX-Cu(II)-Hs were tested against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa and Escherichia coli and it showed prolonged activity compared to that of free Hs.
authors.affiliation: Hanmi Pharmaceutical Co., Kyungkido, Korea.
authors.forename: N J
authors.initials: NJ
authors.lastname: Ha
authors.forename: Y J
authors.initials: YJ
authors.lastname: Jung
authors.forename: J S
authors.initials: JS
authors.lastname: Lee
authors.forename: Y T
authors.initials: YT
authors.lastname: Kim
authors.forename: Y M
authors.initials: YM
authors.lastname: Kim
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011134:Polysaccharides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D009942:Organometallic Compounds; D011134:Polysaccharides; C116962:cotton xanthate-copper(II)-homosulfamine complex