Hepatitis TT virus infection in high-risk groups.
The novel hepatitis TT virus first described by a Japanese group has been reported to be parenterally transmitted and furthermore, to have been detected in patients with hepatitis of unknown etiology. Hence, in the present study its prevalence was investigated within groups at high risk for contracting blood-borne viruses, such as individuals with chronic liver disease, intravenous drug users and recipients of blood and blood products, as compared to voluntary blood donors and pregnant women. To that end, DNA was extracted from sera obtained from the respective patients and subjected to PCR using semi-nested primers. The frequency of TTV DNA detected within high risk groups, such as nine out of 50 patients with chronic non-A-to-G liver disease (18%), nine out of 98 hepatocellular carcinoma cases (9.2%), 17 out of 52 intravenous drug users (32.7%), 15 out of 80 thalassemia patients with multiple blood transfusions (18.8%) and three out of 31 prostitutes (9.7%) exceeded that among voluntary blood donors and pregnant women, which amounted to 14 out of 200 (7%) and seven out of 103 (6.8%), respectively. Additional molecular research should be performed in order to determine its short-, as well as long-term clinical significance.
Poovorawan
Y
Y
Dept. of Pediatrics, Faculty of Medicine, Chulalongkorn University and Hospital, Bangkok, Thailand.
Theamboonlers
A
A
Jantaradsamee
P
P
Kaew-in
N
N
Hirsch
P
P
Tangkitvanich
P
P
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002648:Child; D017931:DNA Primers; D004279:DNA, Viral / Q000097:blood; D005260:Female; D006518:Hepatitis Viruses / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D006525:Hepatitis, Viral, Human / Q000453:epidemiology* / Q000635:transmission / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D015995:Prevalence; D012307:Risk Factors; D012309:Risk-Taking; D011477:Sex Work; D015819:Substance Abuse, Intravenous / Q000150:complications; D013785:Thailand / Q000453:epidemiology; D013789:Thalassemia / Q000150:complications; D065227:Transfusion Reaction
D017931:DNA Primers; D004279:DNA, Viral