Diagnosis and monitoring of cytomegalovirus infection after liver transplantation in children.
Cytomegalovirus infection (CMV) complicated the posttransplant course in 9 of 24 children after liver transplantation. We found specific antibodies (IgG and IgM) to be of very low value in diagnosis and monitoring of CMV infection after liver transplantation. Detection of CMV-DNA by PCR method in the blood or urine was very useful for diagnosis, but less for monitoring of the course of disease and its treatment. Measurements of early immediate CMV antigen (IEA), in peripheral blood leucocytes allowed for very early diagnosis of CMV infection and correlated well with the course of disease and response to treatment of the patient.
Kaliciński
P
P
Department of General Surgery, Child's Health Center Memorial Hospital, Warsaw, Poland.
Kamiński
A
A
Prokurat
A
A
Drewniak
T
T
Chrupek
M
M
Ochalska
B
B
Dzierzanowska
D
D
Szymczak
M
M
Ismail
H
H
Pawłowska
J
J
Kamiński
W
W
D000914:Antibodies, Viral / Q000097:blood; D000998:Antiviral Agents / Q000627:therapeutic use; D002648:Child; D003586:Cytomegalovirus Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D004279:DNA, Viral / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005500:Follow-Up Studies; D015774:Ganciclovir / Q000627:therapeutic use; D006525:Hepatitis, Viral, Human / Q000209:etiology; D006801:Humans; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007962:Leukocytes / Q000821:virology; D016031:Liver Transplantation; D008991:Monitoring, Physiologic; D016133:Polymerase Chain Reaction; D011183:Postoperative Complications / Q000175:diagnosis; D012189:Retrospective Studies
D000914:Antibodies, Viral; D000998:Antiviral Agents; D004279:DNA, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D015774:Ganciclovir