Synthesis and immunosuppressive activity of ruthenium complexes.
The syntheses and immunosuppressive activity of ruthenium complexes are described. One of the complexes (1a) was shown to be a potent inhibitor of human T-lymphocyte proliferation with an IC50 of 5 nM. The activity of these complexes compares favorably to the well known immunosuppressants Cyclosporin A and Rapamycin.
Bastos
C M
CM
Procept, Inc., Cambridge, MA 02139, USA.
Gordon
K A
KA
Ocain
T D
TD
D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D006801:Humans; D007166:Immunosuppressive Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D012428:Ruthenium / Q000737:chemistry*; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects
D007166:Immunosuppressive Agents; D012428:Ruthenium