Pharmacokinetics of weekly transdermal estradiol controlled delivery system in postmenopausal Chinese.
OBJECTIVE
To study Pharmacokinetical profile of weekly transdermal estradiol controlled delivery system (E2-WTCDS) in 18 Chinese postmenopausal women.


METHODS
Single and multiple daily doses of E2-WTCDS were applied to an area of intact skin on the lower abdomen, using Estraderm TTS (E2-TTS) from Ciba-Geigy Company as control. E2 concentration in serum was measured by RIA.


RESULTS
Cmax 38 +/- 5 ng.L-1, Tmax 22 +/- 5 h, AUC 5651 +/- 386 ng.h.L-1, Cmax(SS) 44 +/- 7 ng.L-1, Cmax(SS) 35 +/- 4 ng.L-1, Fl 0.22 +/- 0.10. The relative bioavailability of E2-WTCDS was comparable to E2-TTS during the same period of system application.


CONCLUSIONS
E2-WTCDS maintained relatively constant and effective serum estradiol concentrations and is suitable for once-weekly application.
Chen
G S
GS
Institute of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou, China.
Zhang
M Y
MY
Wang
Q
Q
Ye
J C
JC
D000279:Administration, Cutaneous; D019540:Area Under Curve; D001682:Biological Availability; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D004958:Estradiol / Q000008:administration & dosage / Q000493:pharmacokinetics*; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause / Q000378:metabolism*
D003692:Delayed-Action Preparations; D004958:Estradiol