Fetal development in alloxan-treated rats.
The effect of alloxan on embryo and fetal development in rats was evaluated. Alloxan was injected intraperitoneally (ip) in pregnant rats at doses of 80 to 150 mg/kg at Day 0 (day of fertilization), and 110 mg/kg at Day 4 of pregnancy. Hyperglycemia was rarely produced at alloxan doses from 80 to 100 mg/kg, and the frequency of malformations observed was low. Higher doses (110 to 150 mg/kg) caused severe hyperglycemia, and maternal or embryonic death. When 110 mg/kg was administered on Day 4 of gestation (the day before embryo implantation), all rats had resorption nodules and litters with embryos with delayed growth. We recommend the induction of diabetes mellitus on Day 4 of pregnancy for studies of diabetes-gestation interaction.
Palomar-Morales
M
M
Medical Research Unit in Metabolic Diseases, National Medical Center, Mexican Institute fo Social Security, D.F.
Baiza
L A
LA
Verdín-Terán
L
L
Román-Ramos
R
R
Altamirano-Lozano
M
M
Méndez
J D
JD
D000496:Alloxan / Q000633:toxicity*; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D020964:Embryo Loss / Q000139:chemically induced*; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D006943:Hyperglycemia / Q000139:chemically induced*; D008297:Male; D008431:Maternal-Fetal Exchange / Q000187:drug effects*; D011247:Pregnancy; D051381:Rats
D000496:Alloxan