A potent and selective inhibition of parainfluenza 1 (Sendai) virus by new 6-oxiranyl-, 6-methyloxiranyluracils, and 4(3H)-pyrimidinone derivatives.
Several new 6-oxiranyl-, 6-methyloxiranyluracils, and pyrimidinone derivatives, synthesized by the lithiation-alkylation sequence of 1,3,6-trimethyluracil, 1,3-dimethyl-6-chloromethyluracil, and 2-alkoxy-6-methyl-4(3H)-pyrimidinones, showed a potent and selective antiviral activity against the parainfluenza 1(Sendai) virus replication.
Saladino
R
R
Dipartimento Agrochimico Agrobiologico, Università degli studi di Viterbo La Tuscia, Italy. Saladino@unitus.it
Danti
M C
MC
Mincione
E
E
Crestini
C
C
Palamara
A T
AT
Savini
P
P
Marini
S
S
Botta
M
M
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D004285:Dogs; D011744:Pyrimidinones / Q000737:chemistry / Q000494:pharmacology*; D018108:Respirovirus / Q000187:drug effects* / Q000502:physiology; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D011744:Pyrimidinones