D-2-amino-5-phosphonovalerate, and NMDA receptor antagonist, blocks induction of associative long-term potentiation of the flexion reflex in spinal cat.
The effect of the NMDA receptor antagonist D-2-amino-5-phosphonovalerate (APV) on classical conditioning of the flexion reflex in spinal cat was examined. Animals perfused intrathecally with artificial cerebral spinal fluid (CSF) containing APV exhibited flexion reflex potentiation during the conditioning period that was not significantly different from cats receiving artificial CSF alone. However, the APV group exhibited no signs of reflex potentiation during the 2.5 h retention period, in contrast to the CSF alone group. The results suggest that NMDA receptor activation plays a critical role in the induction of associative long-term potentiation of flexion reflexes in spinal cat.
Durkovic
R G
RG
Department of Neuroscience and Physiology, SUNY Health Science Center at Syracuse, NY 13210, USA. durkovir@vax.cs.hscsyr.edu
Prokowich
L J
LJ
D015763:2-Amino-5-phosphonovalerate / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001667:Binding, Competitive; D002415:Cats; D003213:Conditioning, Psychological / Q000187:drug effects / Q000502:physiology; D005260:Female; D007278:Injections, Spinal; D017774:Long-Term Potentiation / Q000187:drug effects / Q000502:physiology*; D008297:Male; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D012018:Reflex / Q000187:drug effects / Q000502:physiology*; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology*
D016194:Receptors, N-Methyl-D-Aspartate; D015763:2-Amino-5-phosphonovalerate