Pyrazoles, 1,2,4-triazoles, and tetrazoles as surrogates for cis-amide bonds in boronate ester thrombin inhibitors.
Substituted pyrazoles, 1,2,4-triazoles, and tetrazoles are good surrogates for cis-amide bonds in a series of boronate ester thrombin inhibitors.
Duncia
J V
JV
DuPont Merck Pharmaceutical Company, Wilmington, DE 19880-0500, USA.
Santella
J B
JB
Higley
C A
CA
VanAtten
M K
MK
Weber
P C
PC
Alexander
R S
RS
Kettner
C A
CA
Pruitt
J R
JR
Liauw
A Y
AY
Quan
M L
ML
Knabb
R M
RM
Wexler
R R
RR
D000577:Amides / Q000737:chemistry / Q000494:pharmacology*; D001665:Binding Sites; D001897:Boronic Acids / Q000737:chemistry / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D007202:Indicators and Reagents; D008958:Models, Molecular; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013777:Tetrazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013917:Thrombin / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
D000577:Amides; D001897:Boronic Acids; D007202:Indicators and Reagents; D011720:Pyrazoles; D013777:Tetrazoles; D014230:Triazoles; D013917:Thrombin