Influence of feeding on metabolite excretion evidenced by urine 1H NMR spectral profiles: a comparison between subjects living in Rome and subjects living at arctic latitudes (Svaldbard).
Urines from 25 normal subjects living in Rome and 25 normal subjects living in Ny-Alesund (Svaldbard) were analysed by 1HNMR spectroscopy. The observed differences in the concentration of the major metabolites were correlated to the composition of the diet. It was found that a diet rich of carbohydrates, such as the Italian diet, is responsible for an increased excretion of citrate, lactate, alanine, and glycine. Thus, a correct diagnostical interpretation of urinary metabolites needs to consider feeding habits.
Zuppi
C
C
Istituto di Chimica e Chimica Clinica-Centro per la Chimica dei Recettori e delle Molecole Biologicamente Attive, CNR, Università Cattolica del Sacro Cuore, Rome, Italy.
Messana
I
I
Forni
F
F
Ferrari
F
F
Rossi
C
C
Giardina
B
B
D000328:Adult; D000596:Amino Acids / Q000652:urine; D001110:Arctic Regions; D019343:Citric Acid / Q000652:urine; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D004041:Dietary Fats / Q000008:administration & dosage*; D004123:Dimethylamines / Q000652:urine; D005260:Female; D006626:Hippurates / Q000652:urine; D006801:Humans; D019344:Lactic Acid / Q000652:urine; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008744:Methylamines / Q000652:urine; D008875:Middle Aged; D011522:Protons; D012016:Reference Values; D012384:Rome
D000596:Amino Acids; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004123:Dimethylamines; D006626:Hippurates; D008744:Methylamines; D011522:Protons; D019343:Citric Acid; D019344:Lactic Acid; C034516:dimethylamine; C023336:trimethylamine; C030514:hippuric acid