Novel quinolone derivatives as potent antibacterials.
Several 7-(3R,4R-N,N'-dialkyl diaminopyrrolidinyl)-substituted quinolones were synthesized and evaluated for antibacterial activities. 5-Amino-7-(3R,4R-N,N'-dimethyldiamino-6,8-difluoro-1,4-dihydro-1-c yclopropyl -4-oxoquinoline-3-carboxylic acid was found to have potent antibacterial activity against gram +ve organisms.
Lohray
B B
BB
Department of Medicinal Chemistry and Drug Discovery, Dr. Reddy's Research Foundation, Hyderabad, India.
Baskaran
S
S
Rao
B S
BS
Mallesham
B
B
Bharath
K S
KS
Reddy
B Y
BY
Venkateswarlu
S
S
Sadhukhan
A K
AK
Kumar
M S
MS
Sarnaik
H M
HM
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015363:Quinolones / Q000737:chemistry / Q000494:pharmacology*; D013045:Species Specificity; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D015363:Quinolones