title: Cerebellar control of the cardiovascular responses during postural changes in conscious rabbits.
abstract: In conscious control rabbits, tilting the head 30 degrees up from a position 30 degrees down induced initially an inhibition in the renal sympathetic nerve activity (RSNA), however this inhibition immediately released and became a transient increase. Following these responses in RSNA, blood pressure (BP) initially decreased but recovered to the control level within 3-5 s. After bilateral destruction of the lateral nodulus-uvula in the cerebellum, in contrast, the same tilting of the head caused an immediate large increase in RSNA without early inhibition, which was sustained at a high level. BP increased transiently, but then decreased and remained at a level lower than the control. These results indicate that the timing and duration of this transient increase in RSNA during tilting the head up are controlled by the lateral nodulus-uvula and may be important in the rapid adaptation of blood pressure. In addition, this suggests that the lateral nodulus-uvula may play an important role in the cardiovascular control under conditions of consciousness during changes in head position and body posture.
authors.affiliation: Department of Physiology, Oita Medical University, Japan. nisimaru@oita-med.ac.jp
authors.forename: N
authors.initials: N
authors.lastname: Nisimaru
authors.forename: K
authors.initials: K
authors.lastname: Okahara
authors.forename: S
authors.initials: S
authors.lastname: Yanai
mesh_terms: D000818:Animals; D017704:Baroreflex / Q000187:drug effects / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D002531:Cerebellum / Q000502:physiology*; D008297:Male; D011187:Posture / Q000502:physiology*; D011817:Rabbits; D013564:Sympathetic Nervous System / Q000502:physiology*; D018667:Tilt-Table Test