title: Synovium in haemophilic arthropathy.
abstract: Synovium is an essential component of the joint and plays a critical role in maintaining a balance between physiological processes and pathological changes in the joint. Recurrent intra-articular bleeding as occur in haemophilia induce pathological synovial changes in the joint. From a certain point on, synovitis inevitably plays a major role in joint destruction, although in the early phase of haemophilic arthropathy its role may be secondary to cartilage damage as a result of the direct effects of blood on cartilage. The changed haemosiderotic, synovial tissue produces catabolic cytokines and enzymes harmful for cartilage.
authors.affiliation: Van Creveld Clinic, National Haemophilia Centre, University Hospital Utrecht, Utrecht, The Netherlands. G.Roosendaal@digd.azu.nl
authors.forename: G
authors.initials: G
authors.lastname: Roosendaal
authors.forename: E P
authors.initials: EP
authors.lastname: Mauser-Bunschoten
authors.forename: P
authors.initials: P
authors.lastname: De Kleijn
authors.forename: L
authors.initials: L
authors.lastname: Heijnen
authors.forename: H M
authors.initials: HM
authors.lastname: van den Berg
authors.forename: A C
authors.initials: AC
authors.lastname: Van Rinsum
authors.forename: F P
authors.initials: FP
authors.lastname: Lafeber
authors.forename: J W
authors.initials: JW
authors.lastname: Bijlsma
mesh_terms: D002356:Cartilage / Q000378:metabolism / Q000473:pathology; D006467:Hemophilia A / Q000378:metabolism / Q000473:pathology*; D006485:Hemosiderin / Q000378:metabolism; D006801:Humans; D013583:Synovial Membrane / Q000378:metabolism / Q000473:pathology*
chemical_list: D006485:Hemosiderin