title: Synthesis and pharmacological evaluation of new flosulide analogues, synthesized from natural safrole.
abstract: Four new aryl-sulfonamide derivatives (3a, 4a, 5a-b), having methylenedioxy group attached to phenyl ring, were prepared from natural safrole and evaluated as anti-inflammatory agents. The N-methylsulfonamide 3a and corresponding retrosulfonamide derivative 5a were more active than standards indomethacin and nimesulide, at the same molar concentration, in carrageenan-induced pleurisy assay.
authors.affiliation: Laboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio), Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Brazil.
authors.forename: A S
authors.initials: AS
authors.lastname: Lages
authors.forename: K C
authors.initials: KC
authors.lastname: Silva
authors.forename: A L
authors.initials: AL
authors.lastname: Miranda
authors.forename: C A
authors.initials: CA
authors.lastname: Fraga
authors.forename: E J
authors.initials: EJ
authors.lastname: Barreiro
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D016861:Cyclooxygenase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D004195:Disease Models, Animal; D004341:Drug Evaluation; D004487:Edema / Q000188:drug therapy; D005260:Female; D007189:Indans / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D008297:Male; D010998:Pleurisy / Q000188:drug therapy; D051381:Rats; D012451:Safrole / Q000737:chemistry*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D007189:Indans; C059178:flosulide; D012451:Safrole