Viral superinfection in previously unrecognized chronic carriers of hepatitis B virus with superimposed acute fulminant versus nonfulminant hepatitis.
The role of viral superinfection in hepatitis B surface antigen carriers with superimposed fulminant (n = 60) versus nonfulminant (n = 90) acute hepatitis was studied. The frequency of hepatitis A virus (HAV) (0 versus 2.2%), HCV (18.3 versus 21.1%), HDV (15.0 versus 7.8%), and HEV (1.7 versus 4.4%) infection showed no significant difference, while simultaneous HCV and HDV infection was significantly more prevalent in the former (8.3 versus 0%). Only 3. 6% of fulminant cases and 3.3% of nonfulminant controls were HGV RNA positive.
Chu
C M
CM
Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan. gi31208108@adm.cgmh.com.tw
Yeh
C T
CT
Liaw
Y F
YF
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002353:Carrier State; D005260:Female; D006501:Hepatic Encephalopathy / Q000150:complications* / Q000453:epidemiology / Q000821:virology; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D006515:Hepatitis B virus; D019694:Hepatitis B, Chronic / Q000150:complications* / Q000453:epidemiology / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012698:Serologic Tests; D015163:Superinfection / Q000209:etiology / Q000821:virology*
D006514:Hepatitis B Surface Antigens