title: 8-Aminoquinolines as anticoccidials--II.
abstract: During a chemistry program aimed at finding a novel analogue of pentaquine with improved in vivo activity, a number of hypotheses concerning the way this drug acts in the chicken were investigated. Consideration of the products of monoamine oxidase metabolism of pentaquine suggested that pentaquine aldehyde is the likely active metabolite. Although isolation of this unstable compound was not possible, oxime and cyclic acetal and ketal derivatives were obtained and shown to possess in vitro anticoccidial activity.
authors.affiliation: Animal Health Discovery, Pfizer Central Research, Sandwich, Kent, U.K.
authors.forename: R E
authors.initials: RE
authors.lastname: Armer
authors.forename: J S
authors.initials: JS
authors.lastname: Barlow
authors.forename: C J
authors.initials: CJ
authors.lastname: Dutton
authors.forename: D H
authors.initials: DH
authors.lastname: Greenway
authors.forename: S D
authors.initials: SD
authors.lastname: Greenwood
authors.forename: N
authors.initials: N
authors.lastname: Lad
authors.forename: A P
authors.initials: AP
authors.lastname: Thompson
authors.forename: K W
authors.initials: KW
authors.lastname: Thong
authors.forename: I
authors.initials: I
authors.lastname: Tommasini
mesh_terms: D000634:Aminoquinolines / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D002417:Cattle; D002478:Cells, Cultured; D002645:Chickens; D003049:Coccidiostats / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000494:pharmacology*; D008995:Monoamine Oxidase / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology
chemical_list: D000634:Aminoquinolines; D003049:Coccidiostats; D008996:Monoamine Oxidase Inhibitors; D008995:Monoamine Oxidase