Antioxidant effect of two flavonoids from the bark of Ficus bengalensis Linn in hyperlipidemic rats.
Two flavonoid compounds, viz. 5,7-dimethyl ether of leucopelargonidin 3-0-alpha-L rhamnoside and 5,3'-dimethyl ether of leucocyanidin 3-0-alpha-D galactosyl cellobioside obtained from the bark of F. bengalensis were evaluated for their antioxidant action in hyperlipidemic rats. The results were compared with the activity of a structurally similar flavonoid, quercetin, a known antioxidant. The Ficus compounds showed significant antioxidant effects which may be attributed to their polyphenolic nature. The methylation of two hydrozyl groups in the Ficus flavonoids might have slowed down their antioxidant action as compared to quercetin.
Daniel
R S
RS
Department of Biochemistry, University of Kerala, Thiruvananthapuram, India.
Mathew
B C
BC
Devi
K S
KS
Augusti
K T
KT
D000818:Animals; D000872:Anthocyanins; D000975:Antioxidants / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D002475:Cellobiose / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D002839:Chromans / Q000302:isolation & purification / Q000494:pharmacology*; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D006949:Hyperlipidemias / Q000188:drug therapy / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008362:Mannosides / Q000302:isolation & purification / Q000494:pharmacology*; D011794:Quercetin / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D019685:Rosales / Q000737:chemistry; D014197:Trees / Q000737:chemistry
C116874:5,3'-dimethyl leucocyanidin 3-O-galactosyl cellobioside; D000872:Anthocyanins; D000975:Antioxidants; D002839:Chromans; D005419:Flavonoids; D008362:Mannosides; C087775:leucopelargonin; D002475:Cellobiose; D011794:Quercetin