title: In-vitro activity of sanfetrinem against isolates of Streptococcus pneumoniae and Staphylococcus aureus.
abstract: The activity of sanfetrinem (previously GV104326), was assessed against 168 isolates of Streptococcus pneumoniae and 90 isolates of Staphylococcus aureus. These isolates included a range of serotypes or phage types, and varied in their susceptibility to other antibiotics. Sanfetrinem exhibited good anti-pneumococcal activity, with MIC90s of < or = 0.007 mg/L and 0.5 mg/L for penicillin-susceptible and penicillin-resistant isolates, respectively. Sanfetrinem was also active against methicillin-susceptible staphylococci (MIC90 = 0.06 mg/L). However, the MICs of sanfetrinem for isolates with methicillin MICs of 8-16 mg/L and > or = 32 mg/L were 0.25-1 mg/L and 8->32 mg/L, respectively.
authors.affiliation: Laboratory of Hospital Infection, Central Public Health Laboratory, Colindale, London, UK. ajohnson@phls.co.uk
authors.forename: A P
authors.initials: AP
authors.lastname: Johnson
authors.forename: M
authors.initials: M
authors.lastname: Warner
authors.forename: D C
authors.initials: DC
authors.lastname: Speller
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001434:Bacteriophage Typing; D004352:Drug Resistance, Microbial; D004917:Erythromycin / Q000494:pharmacology; D006801:Humans; D007769:Lactams; D008712:Methicillin / Q000494:pharmacology; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology; D011008:Pneumococcal Infections / Q000382:microbiology; D012703:Serotyping; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D013296:Streptococcus pneumoniae / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D007769:Lactams; D010406:Penicillins; C104757:sanfetrinem; D004917:Erythromycin; D008712:Methicillin