Effects of inorganic salts on solubilization of estriol in an aqueous solution of poly(ethylene oxide)/poly(propylene oxide)/poly(ethylene oxide) triblock copolymer.
The effects of inorganic salts on the solubilization of estriol was studied in an aqueous solution of a poly(ethylene oxide)/poly(propylene oxide)/poly(ethylene oxide) triblock copolymer (Pluronic L-64). The solubility of estriol increased with increasing Pluronic L-64 and salt concentrations. Furthermore, two clear transition points corresponding to the polymolecular micelle formation and a pronounced change in micellar structure of Pluronic L-64 were found on the solubility curves. The effectiveness of inorganic salts for increasing solubility of estriol followed approximately the lyotropic or Hofmeister series, except Li+.
Saito
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Y
College of Pharmacy, Nihon University, Chiba, Japan. saitoyoshi@msn.com
Sato
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T
D004339:Drug Compounding / Q000379:methods; D004964:Estriol / Q000008:administration & dosage / Q000302:isolation & purification*; D006801:Humans; D008823:Micelles; D011092:Polyethylene Glycols; D011108:Polymers; D011409:Propylene Glycols; D012492:Salts; D012995:Solubility; D014867:Water
D008823:Micelles; D011108:Polymers; D011409:Propylene Glycols; D012492:Salts; D014867:Water; C012504:polypropylene glycol; D011092:Polyethylene Glycols; D004964:Estriol