Synthesis and binding studies of a 1-alkyl-3,6-diamino-4-quinolone based receptor for N-acylated dipeptides.
The synthesis and binding properties of a semirigid host for N-acyldipeptide carboxylic acids is presented. The design is based on the rigidification of a peptide strand, coupled to the use of a substituted quinoline as a hydrogen bond acceptor for the proton of a carboxylic acid.
Weiner
W S
WS
Department of Chemistry, University of Pittsburgh, PA 15260, USA.
Hamilton
A D
AD
D000215:Acylation; D004151:Dipeptides / Q000378:metabolism*; D015195:Drug Design; D006860:Hydrogen Bonding; D008958:Models, Molecular; D018716:Molecular Mimicry; D011485:Protein Binding; D017433:Protein Structure, Secondary; D015363:Quinolones / Q000138:chemical synthesis* / Q000378:metabolism*
D004151:Dipeptides; D015363:Quinolones