[Clinical study of sudden deafness treated with method of integrated traditional Chinese and Western medicine].
OBJECTIVE
To explore the mechanisms of sudden deafness treated with integrated traditional Chinese and Western medicine (TCM-WM).


METHODS
One hundred and forty-six patients suffering from sudden deafness were divided into two groups, 64 cases of treated group treated with the method of integrated TCM-WM and the other 82 cases treated with Western medicine alone for control.


RESULTS
The total effective rate of the treated group was 92.19%, that of the control group was 75.61%. The difference between two groups was significant, P < 0.01.


CONCLUSIONS
The integrated method is very effective in treating sudden deafness. Its mechanism might be: (1) Decrease the blood viscosity and increase the red blood cell's tenacity, so that the blood stream is passing through unimpeded. (2) Decrease the plasma TXA2 level and increase the PGI2 level, keep the blood supply for inner ear. (3) Increase the activity of SOD and clear away the free radicals so as to reduce the damage of inner ear.
Zhang
X Y
XY
Department of Biochemistry, Jining Medical College, Shandong.
Qian
X M
XM
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000328:Adult; D001809:Blood Viscosity / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004907:Erythrocyte Deformability; D005260:Female; D003639:Hearing Loss, Sudden / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013482:Superoxide Dismutase / Q000097:blood; D013929:Thromboxane B2 / Q000097:blood
D004365:Drugs, Chinese Herbal; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D013482:Superoxide Dismutase