title: Effects of TRH administration on orientation time and recall after ECT.
abstract: We investigated the effect of thyrotropin-releasing hormone (TRH) on orientation time and recall, in nine depressed female inpatients undergoing electroconvulsive therapy (ECT). In a balanced order crossover design, an intravenous bolus of 0.4 mg TRH or placebo was administered 20 min before ECT in the first two sessions. Orientation time and retrograde and anterograde components of the memory dysfunction, immediately and 24 h later, were assessed. Administration of TRH did not influence orientation time, word recall, or immediate short story recall compared with placebo. We did find, however, an improvement in the number of short story items recalled after 24 h when patients were given TRH compared with placebo. This indicates that TRH may have a protective role against the specific negative effect of ECT on delayed recall.
authors.affiliation: Department of Psychiatry, Athens University Medical School, Eginition Hospital, Greece.
authors.forename: I M
authors.initials: IM
authors.lastname: Zervas
authors.forename: A A
authors.initials: AA
authors.lastname: Pehlivanidis
authors.forename: Y G
authors.initials: YG
authors.lastname: Papakostas
authors.forename: M
authors.initials: M
authors.lastname: Markianos
authors.forename: G N
authors.initials: GN
authors.lastname: Papadimitriou
authors.forename: C N
authors.initials: CN
authors.lastname: Stefanis
mesh_terms: D000328:Adult; D000368:Aged; D003866:Depressive Disorder / Q000628:therapy*; D004565:Electroconvulsive Therapy / Q000009:adverse effects; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D011939:Mental Recall / Q000187:drug effects*; D008875:Middle Aged; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D013973:Thyrotropin-Releasing Hormone