[The comparative characteristics of the metabolic effects of amtizol and trimetazidine in acute hypoxia].
Experiments were conducted on rats to study the effect of amtizol and trimetazidine on energy metabolism and lipid peroxidation in the brain, heart, and liver in acute hypoxia. Hypoxia was modelled by "raising" the animals in a pressure chamber to a "height" of 8,000-11,000 m, the exposure lasted 30 min. Equal doses (25 mg/kg) of the drugs were injected intraperitoneally 30 min before the "ascent". It was found that amtizol, just like trimetazidine, prevented energy metabolism disorders and activation of lipid peroxidation in the organs. The metabolic effects of the drugs were unidirectional, but the antioxidant activity of amtizol was pronounced more.
Smirnov
A V
AV
Department of Pharmacology, Military Medical Academy, Russian Federation, St. Petersburg, Russia.
Zarubina
I V
IV
Krivoruchko
B I
BI
Mironova
O P
OP
D000208:Acute Disease; D000531:Altitude; D000704:Analysis of Variance; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004734:Energy Metabolism / Q000187:drug effects; D000860:Hypoxia / Q000188:drug therapy* / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051381:Rats; D013830:Thiadiazoles / Q000627:therapeutic use*; D014292:Trimetazidine / Q000627:therapeutic use*
D013830:Thiadiazoles; C044365:amtizol; D014292:Trimetazidine
Sravnitel'naia kharakteristika metabolicheskikh éffektov amtizola i trimetazidina pri ostroĭ gipoksii.