title: Asymmetric imine-ene reactions: diastereofacial selective reactions with chiral glyoxylate-derived alpha-imino esters and asymmetric catalysis of enantiofacial selective reactions with prochiral alpha-imino esters.
abstract: The diastereofacial selective "imine-ene" reactions with alpha-imino esters, prepared from (-)-8-phenylmenthyl glyoxylate, are shown to provide an efficient entry to the asymmetric synthesis of alpha-amino acids. The feasibility study of the asymmetric catalysis is also reported on the enantiofacial selective ene reactions with prochiral alpha-imino esters.
authors.affiliation: Department of Chemical Technology, Tokyo Institute of Technology, Japan. kmikami@o.cc.titech.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Mikami
authors.forename: T
authors.initials: T
authors.lastname: Yajima
authors.forename: M
authors.initials: M
authors.lastname: Kaneko
mesh_terms: D000596:Amino Acids; D002384:Catalysis; D006038:Glyoxylates; D007097:Imines; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D006038:Glyoxylates; D007097:Imines