The cholesterol metabolite cholest-4-en-3-one and its 3-oxo derivatives suppress body weight gain, body fat accumulation and serum lipid concentration in mice.
Based on the findings that cholest-4-en-3-one, an intestinal metabolite of cholesterol, has an anti-obesity effect on animals, the structure-effect relationship of its 3-oxo derivatives and related compounds were investigated. Cholesten-3-ones, which possesses an enone structure with a carbonyl group at C3, markedly inhibit body weight gain and body fat accumulation, as well as the levels of serum triglyceride and cholesterol in animals without any clinical abnormalities.
Suzuki
K
K
Animal and Cellular Systems Laboratory, Institute of Physical and Chemical Research (RIKEN), Saitama, Japan.
Shimizu
T
T
Nakata
T
T
D000273:Adipose Tissue / Q000033:anatomy & histology / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D002783:Cholestenones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002784:Cholesterol / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D008055:Lipids / Q000097:blood*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D015394:Molecular Structure; D009929:Organ Size / Q000187:drug effects; D013329:Structure-Activity Relationship; D015430:Weight Gain / Q000187:drug effects*
D002783:Cholestenones; D008055:Lipids; C000475:cholest-4-en-3-one; D002784:Cholesterol