title: Immunoblastic lymphadenopathy-like T cell lymphoma evolving into a massive plasma cell proliferation with biclonal paraproteinemia.
abstract: We present a case of immunoblastic lymphadenopathy-like T cell lymphoma (IBL-T) who subsequently developed a massive proliferation of plasma cells. At diagnosis of IBL-T, the patient had polyclonal hypergammaglobulinemia and subsequently, while on chemotherapy, developed paraproteinemia with biclonal peaks and the IBL-T lesion was replaced with a massive proliferation of CD38-positive plasma cells. The evolution was not likely to be attributed to a new neoplastic proliferation of B cells. It appeared that two B cell clones possibly had a growth advantage among the polyclonal B cells due to a depletion of suppressor T cells or to a disturbance in the immune system.
authors.affiliation: Division of Hematology, Internal Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Higuchi
authors.forename: J
authors.initials: J
authors.lastname: Tada
authors.forename: H
authors.initials: H
authors.lastname: Mori
authors.forename: H
authors.initials: H
authors.lastname: Niikura
authors.forename: M
authors.initials: M
authors.lastname: Omine
authors.forename: K
authors.initials: K
authors.lastname: Kishimoto
authors.forename: G
authors.initials: G
authors.lastname: Tate
authors.forename: T
authors.initials: T
authors.lastname: Mitsuya
mesh_terms: D036541:ADP-ribosyl Cyclase; D051997:ADP-ribosyl Cyclase 1; D000368:Aged; D015703:Antigens, CD; D000943:Antigens, Differentiation; D002455:Cell Division; D005260:Female; D005434:Flow Cytometry; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications* / Q000276:immunology; D007119:Immunoblastic Lymphadenopathy / Q000150:complications* / Q000276:immunology; D016399:Lymphoma, T-Cell / Q000150:complications* / Q000276:immunology; D008562:Membrane Glycoproteins; D009244:NAD+ Nucleosidase; D010265:Paraproteinemias / Q000150:complications* / Q000276:immunology; D010950:Plasma Cells / Q000276:immunology / Q000473:pathology*
chemical_list: D015703:Antigens, CD; D000943:Antigens, Differentiation; D008562:Membrane Glycoproteins; D036541:ADP-ribosyl Cyclase; C498154:CD38 protein, human; D009244:NAD+ Nucleosidase; D051997:ADP-ribosyl Cyclase 1