Influence of Aloe vera on collagen turnover in healing of dermal wounds in rats.
Treatment of full-thickness wounds with A. vera, on rats resulted in increased biosynthesis of collagen and its degradation. A corresponding increase in the urinary excretion of hydroxyproline was also observed. Elevated levels of lysyl oxidase also indicated increased crosslinking of newly synthesised collagen. The results suggest that A. vera influences the wound healing process by enhancing collagen turnover in the wound tissue.
Chithra
P
P
Department of Biochemistry, Central Leather Research Institute, Adyar, Chennai, India.
Sajithlal
G B
GB
Chandrakasan
G
G
D000504:Aloe; D000818:Animals; D003094:Collagen / Q000096:biosynthesis / Q000378:metabolism*; D017364:Collagenases / Q000378:metabolism; D006909:Hydroxyproline / Q000652:urine; D008297:Male; D010946:Plants, Medicinal; D008249:Protein-Lysine 6-Oxidase / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000293:injuries* / Q000378:metabolism*; D014945:Wound Healing
D003094:Collagen; D008249:Protein-Lysine 6-Oxidase; D017364:Collagenases; D006909:Hydroxyproline