title: Retinal microvasculopathy in human immunodeficiency type 1 (HIV)-infected children.
abstract: OBJECTIVE
  To report two cases of retinal peripheral lesions in vertically HIV-infected children.
  
  
  METHODS
  Complete ophthalmological examinations were performed in both cases over a period of four years.
  
  
  RESULTS
  We found retinal peripheral lesions in four eyes of two patients who were referred to us for routine examination. Both cases showed focal, segmental and white patches around the vessel wall in the far periphery and at the equator. These findings hardly changed after 3.5 and 2.5 years of follow-up, respectively. We suppose the cause of these lesions is an immune-mediated reaction.
  
  
  CONCLUSIONS
  Even although there is a low incidence of retinal alterations in pediatric patients infected by HIV, we believe that complete and systematic ophthalmic examinations should be performed in these children.
authors.affiliation: Department of Ophthalmology, Hospital Doce de Octubre, Madrid, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Tejada
authors.forename: B
authors.initials: B
authors.lastname: Sarmiento
authors.forename: J R
authors.initials: JR
authors.lastname: Ramos
mesh_terms: D015526:AIDS Dementia Complex / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D000293:Adolescent; D019380:Anti-HIV Agents / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D002648:Child; D004279:DNA, Viral / Q000032:analysis; D003937:Diagnosis, Differential; D016049:Didanosine / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D015497:HIV-1 / Q000235:genetics; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D012171:Retinal Vessels / Q000473:pathology*; D012173:Retinitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D014657:Vasculitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D015215:Zidovudine / Q000627:therapeutic use
chemical_list: D019380:Anti-HIV Agents; D004279:DNA, Viral; D015215:Zidovudine; D016049:Didanosine