Experimental arterial lesions after narrow-beam gamma irradiation used in stereotactic radiosurgery.
An experimental study on rats showing the arterial lesions caused by the beams of gamma irradiation used in stereotactic radiosurgery is presented. The common carotid artery of the rat was irradiated with a single narrow-beam of gamma radiation with a maximum dose of 30 and 60 Gy. The results were evaluated at 4, 12 and 24 weeks after irradiation. Several focal changes in the arterial walls were observed in all periods of study with a predominance of hyperplastic (proliferative) alterations at doses of 30 Gy, and hyaline degeneration at doses of 60 Gy. Total occlusion was not observed in any case. In conclusion, vascular hyperplasia is more prominent with the lower doses evaluated.
Joanes
V
V
Department of Neurosurgery, University General Hospital, Valencia, Spain.
Cerdá-Nicolas
M
M
Ciudad
J
J
Barcia-Salorio
J L
JL
D000818:Animals; D001921:Brain / Q000098:blood supply*; D020212:Carotid Artery Injuries; D017536:Carotid Artery, Common / Q000473:pathology; D016893:Carotid Stenosis / Q000473:pathology; D004730:Endothelium, Vascular / Q000473:pathology; D005352:Fibromuscular Dysplasia / Q000473:pathology; D008297:Male; D016634:Radiosurgery / Q000295:instrumentation*; D051381:Rats; D017208:Rats, Wistar