title: Development of tablets for controlled joint release of nifedipine and atenolol.
abstract: Oral combinations of nifedipine and atenolol are widely used in the treatment of hypertension, proving particularly effective when the atenolol is released immediately and the nifedipine is released in a sustained manner. This work examined the potential of combining nifedipine and atenolol in a tablet, which would be easier to manufacture than currently available combined formulations. The results indicated that a 40:60 (w/w) nifedipine-atenolol mixture forms a eutectic melting at 140 degrees C. Nevertheless, both drugs were stable when incorporated in tablets elaborated using cellulose ethers as base excipients. Tablets prepared from atenolol-lactose granules and solid dispersions of nifedipine-hydroxypropylmethylcellulose (100 cP) had more adequate dissolution profiles than a more complex reference formulation in hard capsules.
authors.affiliation: Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Iglesias
authors.forename: C
authors.initials: C
authors.lastname: Taboada
authors.forename: C
authors.initials: C
authors.lastname: Souto
authors.forename: R
authors.initials: R
authors.lastname: Martínez-Pacheco
authors.forename: J L
authors.initials: JL
authors.lastname: Gómez-Amoza
authors.forename: A
authors.initials: A
authors.lastname: Concheiro
mesh_terms: D001262:Atenolol / Q000493:pharmacokinetics*; D002121:Calcium Channel Blockers / Q000493:pharmacokinetics*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003692:Delayed-Action Preparations; D004355:Drug Stability; D004987:Ethers; D006973:Hypertension / Q000188:drug therapy*; D008055:Lipids / Q000737:chemistry; D009543:Nifedipine / Q000493:pharmacokinetics*; D012995:Solubility; D013607:Tablets; D014867:Water / Q000737:chemistry
chemical_list: D002121:Calcium Channel Blockers; D003692:Delayed-Action Preparations; D004987:Ethers; D008055:Lipids; D013607:Tablets; D014867:Water; D001262:Atenolol; D009543:Nifedipine