N-(2-(4-hydroxyphenyl)ethyl)-4-chlorocinnamide: a novel antagonist at the 1A/2B NMDA receptor subtype.
A series of N-(2-phenethyl)cinnamides was synthesized and assayed for antagonism at three N-methyl-D-asparate (NMDA) receptor subtypes (NR1A/2A-C). N-(2-(4-hydroxyphenyl)ethyl)-4-chlorocinnamide (6) was identified as a highly potent and selective antagonist of the NR1A/2B subtype.
Tamiz
A P
AP
Department of Chemistry, University of Oregon, Eugene 97403, USA.
Whittemore
E R
ER
Schelkun
R M
RM
Yuen
P W
PW
Woodward
R M
RM
Cai
S X
SX
Weber
E
E
Keana
J F
JF
D002934:Cinnamates / Q000737:chemistry / Q000494:pharmacology*; D018691:Excitatory Amino Acid Antagonists / Q000737:chemistry / Q000494:pharmacology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
D002934:Cinnamates; D018691:Excitatory Amino Acid Antagonists; C116443:N-(2-(hydroxyphenyl)ethyl)-4-chlorocinnamide; D016194:Receptors, N-Methyl-D-Aspartate