[Effect of Salvia miltiorrhizae Composita on erythrocyte membrane phospholipid in patients with coronary heart disease].
OBJECTIVE
To investigate the function of phospholipid metabolism in pathogenesis of coronary heart disease (CHD) and the effect of Salvia miltiorrhizae Composita (SMC) on it.


METHODS
The levels of erythrocyte membrane phospholipid, blood lipid peroxide (LPO), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were determined in the patients with CHD by Thinlayer chromatography and fluorimetry during the treatment of SMC.


RESULTS
Sphingomyelins (SM), phosphatidyl serine (PS), phosphatidyl ethanolamine (PE) and lysophosphatide (LL) of erythrocyte membrane phospholipid were increased in patients with CHD. Phosphatidyl cholines (PC) was lower than control group. Among them, the ratios of SM/PC and PS/PC were significantly higher. In the patients with CHD, LPO was significantly increased and ratios of SOD/LPO and GSH-Px/LPO significantly decreased. After the treatment with SMC, LL, SM, PS and PE of erythrocyte phospholipid and the ratios of SM/PC and PS/PC and LPO were decreased. PC and SOD/LPO were increased.


CONCLUSIONS
The abnormality of erythrocyte membrane phospholipid participate the occurrence and development of CHD. SMC might improve the abnormality of erythrocyte phospholipid and lipid peroxide and possess the effect of regulating phospholipid metabolism.
Wei
X D
XD
Department of Biochemistry, Jiamusi Medical College, Heilongjiang.
Li
L
L
Bai
J
J
D000328:Adult; D000368:Aged; D003327:Coronary Disease / Q000097:blood*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010714:Phosphatidylethanolamines / Q000097:blood; D010718:Phosphatidylserines / Q000097:blood; D010743:Phospholipids / Q000097:blood*; D010936:Plant Extracts; D027561:Salvia miltiorrhiza; D013109:Sphingomyelins / Q000097:blood
D004365:Drugs, Chinese Herbal; D010714:Phosphatidylethanolamines; D010718:Phosphatidylserines; D010743:Phospholipids; D010936:Plant Extracts; D013109:Sphingomyelins