title: The asymmetric synthesis and in vitro characterization of succinyl mercaptoalcohol and mercaptoketone inhibitors of matrix metalloproteinases.
abstract: A series of succinyl based mercaptoketones and diastereomeric mercaptoalcohols were prepared and evaluated in vitro as inhibitors of the matrix metalloproteinases collagenase-1 (MMP-1), stromelysin (MMP-3), and gelatinase-B (MMP-9).
authors.affiliation: Wyeth-Ayerst Research, Pearl River, New York 10965, USA.
authors.forename: J I
authors.initials: JI
authors.lastname: Levin
authors.forename: J F
authors.initials: JF
authors.lastname: DiJoseph
authors.forename: L M
authors.initials: LM
authors.lastname: Killar
authors.forename: M A
authors.initials: MA
authors.lastname: Sharr
authors.forename: J S
authors.initials: JS
authors.lastname: Skotnicki
authors.forename: D V
authors.initials: DV
authors.lastname: Patel
authors.forename: X Y
authors.initials: XY
authors.lastname: Xiao
authors.forename: L
authors.initials: L
authors.lastname: Shi
authors.forename: M
authors.initials: M
authors.lastname: Navre
authors.forename: D A
authors.initials: DA
authors.lastname: Campbell
mesh_terms: D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D007202:Indicators and Reagents; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007700:Kinetics; D020781:Matrix Metalloproteinase 1; D020780:Matrix Metalloproteinase 9; D061965:Matrix Metalloproteinase Inhibitors; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors*; D015394:Molecular Structure; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013386:Succinates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000438:Alcohols; D007202:Indicators and Reagents; D007659:Ketones; D061965:Matrix Metalloproteinase Inhibitors; D011480:Protease Inhibitors; D013386:Succinates; D013438:Sulfhydryl Compounds; D008666:Metalloendopeptidases; D020780:Matrix Metalloproteinase 9; D020781:Matrix Metalloproteinase 1