title: Therapeutic strategies based on immunological hypotheses of Alzheimer's disease.
abstract: There are several findings demonstrating the importance of inflammatory or immunological processes in the etiopathogenesis of Alzheimer's disease (AD). Several studies on nonsteroidal anti-inflammatory drugs (NSAID) give evidence for a therapeutic effect of these drugs in AD, among other the prospective double-blind placebo-controlled study on indomethacin, strongly support the therapeutic effect of these agents. Possibly also the therapeutic effects of propentofylline might be interpreted in the light of this theory.
authors.affiliation: Psychiatric Hospital, Ludwig-Maximilians-University, Munich, Federal Republic of Germany.
authors.forename: H J
authors.initials: HJ
authors.lastname: Möller
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000276:immunology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D018849:Controlled Clinical Trials as Topic; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use; D008297:Male; D018448:Models, Immunological; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D014970:Xanthines / Q000627:therapeutic use*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D018696:Neuroprotective Agents; D014970:Xanthines; C032114:propentofylline; D007213:Indomethacin