Oxidants and antioxidants in the pathogenesis of atherosclerosis: implications for the oxidized low density lipoprotein hypothesis.
The oxidation hypothesis proposes that low density lipoprotein must be oxidatively modified to trigger the pathological events of atherosclerosis. In this article, we evaluate recent studies addressing the pathways that promote low density lipoprotein oxidation in vivo and the impact of antioxidants on atherogenesis in animals, paying particular attention to the clinical implications of these studies for the oxidation hypothesis.
Heinecke
J W
JW
Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. heinecke@im.wustl.edu
D000818:Animals; D000975:Antioxidants / Q000378:metabolism* / Q000494:pharmacology; D001158:Arteries / Q000378:metabolism; D001161:Arteriosclerosis / Q000503:physiopathology* / Q000517:prevention & control; D003300:Copper / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000502:physiology*; D008084:Lipoxygenase / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D010084:Oxidation-Reduction; D009195:Peroxidase / Q000378:metabolism
D000975:Antioxidants; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D009569:Nitric Oxide; D003300:Copper; D007501:Iron; D009195:Peroxidase; D008084:Lipoxygenase