Boron trifluoride etherate on silica-A modified Lewis acid reagent (VII). Antitumor activity of cannabigerol against human oral epitheloid carcinoma cells.
Geraniol (1), olivetol (2), cannabinoids (3 and 4) and 5-fluorouracil (5) were tested for their growth inhibitory effects against human oral epitheloid carcinoma cell lines (KB) and NIH 3T3 fibroblasts using two different 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay and sulforhodamine B protein (SRB) assay. Cannabigerol (3) exhibited the highest growth-inhibitory activity against the cancer cell lines.
Baek
S H
SH
Department of Chemistry, Wonkwang University, Iksan, Korea.
Kim
Y O
YO
Kwag
J S
JS
Choi
K E
KE
Jung
W Y
WY
Han
D S
DS
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001880:Boranes; D002186:Cannabinoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002277:Carcinoma / Q000188:drug therapy*; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009062:Mouth Neoplasms / Q000188:drug therapy*; D009580:Nitroblue Tetrazolium; D012822:Silicon Dioxide; D013055:Spectrophotometry, Infrared
D000972:Antineoplastic Agents, Phytogenic; D001880:Boranes; D002186:Cannabinoids; D009580:Nitroblue Tetrazolium; C101707:boron trifluoride etherate; D012822:Silicon Dioxide; C037036:cannabigerol