title: Synthesis and biological evaluation of 1,2,5-oxadiazole N-oxide derivatives as hypoxia-selective cytotoxins.
abstract: Synthesis and biological evaluation of new 1,2,5-oxadiazole N-oxide derivatives with potential cytotoxic effects are described. From the series of compounds tested, compounds 2 and 6 proved to be very active, although non-selective.
authors.affiliation: Department of Medicinal Chemistry, University of Navarra, Pamplona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Monge
authors.forename: A
authors.initials: A
authors.lastname: López de Ceráin
authors.forename: O
authors.initials: O
authors.lastname: Ezpeleta
authors.forename: H
authors.initials: H
authors.lastname: Cerecetto
authors.forename: E
authors.initials: E
authors.lastname: Dias
authors.forename: R
authors.initials: R
authors.lastname: Di Maio
authors.forename: M
authors.initials: M
authors.lastname: González
authors.forename: S
authors.initials: S
authors.lastname: Onetto
authors.forename: G
authors.initials: G
authors.lastname: Seoane
authors.forename: L
authors.initials: L
authors.lastname: Suescun
authors.forename: R
authors.initials: R
authors.lastname: Mariezcurrena
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015687:Cell Hypoxia / Q000187:drug effects; D006224:Cricetinae; D003412:Cricetulus; D003497:Cyclic N-Oxides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D008958:Models, Molecular; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D014961:X-Ray Diffraction
chemical_list: C116849:3-chloromethyl-4-phenyl-1,2,5-oxadiazole-2-oxide; C116850:4-phenyl-1,2,5-oxadiazole-3-carboxaldehyde-2-oxide; D000970:Antineoplastic Agents; D003497:Cyclic N-Oxides; D010069:Oxadiazoles