title: Intraventricular perineurioma: case report.
abstract: OBJECTIVE
  Perineurioma, a rare benign nerve sheath neoplasm occurring in either an intraneural or soft tissue form, has never been reported to arise in the central nervous system.
  
  
  METHODS
  We describe the clinical, radiological, and pathological features of a perineurioma arising in the choroid plexus of the third ventricle in a 65-year-old woman and causing obstructive hydrocephalus.
  
  
  METHODS
  The lesion, apparently unassociated with a nerve, was gross totally resected by frontal craniotomy using a left-sided transcallosal approach. Short-term follow-up showed no evidence of recurrence.
  
  
  CONCLUSIONS
  Perineurioma of the variety found in soft tissue may occur in the central nervous system, wherein it shows the typical light microscopic, immunohistochemical (epithelial membrane antigen- and Collagen IV-positive, S-100 protein-negative), and ultrastructural (pinocytotic vesicles, discontinuous basement membrane) features.
authors.affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.
authors.forename: C
authors.initials: C
authors.lastname: Giannini
authors.forename: B W
authors.initials: BW
authors.lastname: Scheithauer
authors.forename: J
authors.initials: J
authors.lastname: Steinberg
authors.forename: T J
authors.initials: TJ
authors.lastname: Cosgrove
mesh_terms: D000368:Aged; D001259:Ataxia / Q000209:etiology; D014408:Biomarkers, Tumor / Q000032:analysis; D016545:Choroid Plexus Neoplasms / Q000737:chemistry / Q000150:complications / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D003094:Collagen / Q000032:analysis; D003399:Craniotomy; D003704:Dementia / Q000209:etiology; D003937:Diagnosis, Differential; D005260:Female; D006261:Headache / Q000209:etiology; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology / Q000601:surgery; D008579:Meningioma / Q000175:diagnosis; D018396:Mucin-1 / Q000032:analysis; D009363:Neoplasm Proteins / Q000032:analysis; D018317:Nerve Sheath Neoplasms / Q000737:chemistry / Q000150:complications / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D009419:Nerve Tissue Proteins / Q000032:analysis; D020033:Protein Isoforms / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D018396:Mucin-1; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; D020033:Protein Isoforms; D003094:Collagen