Electrochemical studies of S-nitrosothiols.
S-nitrosothiols (RSNO), such as SNAP, GSNO, and Glc-SNAP-1 exhibited a single, totally irreversible, diffusion controlled reduction peak at potentials of -0.97 V, -0.98 V and -0.91 V, respectively, vs. Ag/AgCl (3 M NaCl) reference electrode. This corresponded to the nitric oxide (NO) release from the S-nitrosothiols. A possible mechanism is proposed for the reduction process.
Hou
Y
Y
Department of Chemistry, Wayne State University, Detroit, MI 48202, USA.
Wang
J
J
Arias
F
F
Echegoyen
L
L
Wang
P G
PG
D004563:Electrochemistry; D005978:Glutathione / Q000031:analogs & derivatives* / Q000737:chemistry; D008623:Mercaptoethanol; D009603:Nitroso Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D010396:Penicillamine / Q000031:analogs & derivatives* / Q000737:chemistry; D026422:S-Nitrosoglutathione; D026403:S-Nitrosothiols
D009603:Nitroso Compounds; D026403:S-Nitrosothiols; C110881:S-nitro-N-acetylpenicillamine; D026422:S-Nitrosoglutathione; D008623:Mercaptoethanol; C032635:S-nitrosomercaptoethanol; D005978:Glutathione; D010396:Penicillamine