title: Congenital conduction defects in children born to asymptomatic mothers with anti-SSA/SSB antibodies: report of two cases.
abstract: It is very difficult to identify pregnant asymptomatic mothers carrying anti-SSA/SSB antibodies. We report two cases of neonatal lupus erythematosus, born to asymptomatic mothers with anti-SSA/Ro antibody, who developed isolated complete congenital cardiac heart block and transient second degree conduction defect associated with cardiac abnormalities, respectively. The first died suddenly of acute myocarditis at the age of 20 months, while the second underwent surgery at the age of 10 years for a ventricular septal defect, after two episodes of second degree atrioventricular block in infancy. We believe that in both cases the diagnosis could have been made in utero after correct heart beat analysis. We propose careful monitoring of fetal heart beat in all pregnant mothers. The occurrence of heart beat modification should prompt clinicians to test the mother for antibody positivity. This approach may permit early diagnosis and in utero treatment in order to spare the child from cardiac conduction defects. We provide the evidence of these cases and propose a flow chart for all physicians dealing with pregnancy.
authors.affiliation: Dipartimento di Pediatria, Servizio di Reumatologia, Azienda Ospedaliera A. Meyer di Firenze.
authors.forename: F
authors.initials: F
authors.lastname: Falcini
authors.forename: L
authors.initials: L
authors.lastname: De Simone
authors.forename: G
authors.initials: G
authors.lastname: Donzelli
authors.forename: M M
authors.initials: MM
authors.lastname: Cerinic
mesh_terms: D000328:Adult; D000906:Antibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology*; D002648:Child; D005260:Female; D006327:Heart Block / Q000151:congenital* / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D008180:Lupus Erythematosus, Systemic / Q000151:congenital* / Q000276:immunology; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins / Q000276:immunology*; D000097585:SS-B Antigen; D000099207:SS-A Antigen
chemical_list: D000906:Antibodies; D001324:Autoantigens; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; D000097585:SS-B Antigen; D000099207:SS-A Antigen; C116006:RO60 protein, human