title: Synthesis and antibacterial in vitro activity of novel analogues of nematophin.
abstract: The synthesis and in vitro antibacterial activity of new derivatives and analogues of nematophin are described. It was shown that the unsubstituted amide NH-group is essential for bioactivity. Alkyl- or arylsubstitution at the 1-position results in a distinct increase of antibacterial activity. Addition of protein (blood or serum) to the culture media reduces the inhibitory activity on bacteria.
authors.affiliation: Bayer AG, Leverkusen, Germany. THOMAS.HIMMLER.TH@Bayer-AG.de
authors.forename: T
authors.initials: T
authors.lastname: Himmler
authors.forename: F
authors.initials: F
authors.lastname: Pirro
authors.forename: N
authors.initials: N
authors.lastname: Schmeer
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D003470:Culture Media; D007211:Indoles / Q000138:chemical synthesis / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013045:Species Specificity; D013210:Staphylococcus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D003470:Culture Media; D007211:Indoles; C109330:nematophin