Type I interferon gene expression: differential expression of IFN-A genes induced by viruses and double-stranded RNA.
The family of interferon regulatory transcription factors (IRF) participates in the virus-induced and dsRNA-stimulated transcriptional regulation of either type I IFN genes or a definite set of genes which can also be activated by IFN. In this review, we place emphasis on the role of IRF-3 that associates with the coactivators CBP and/or p300, together or not with IRF-7. These complexes bind to the PRDI, PRDI-like domains or to a number of ISRE sequences located in the promoter of these virus-inducible genes. We also discuss the involvement of the IRF-3-related complexes in the differential regulation of IFN-A genes.
Bragança
J
J
UPR 37-CNRS, Laboratoire de Régulation de l'Expression des Gènes Eucaryotes, UFR Biomédicale des Saints-Pères, Université Paris V, France.
Civas
A
A
D000818:Animals; D001483:Base Sequence; D005786:Gene Expression Regulation; D006801:Humans; D007370:Interferon Type I / Q000235:genetics*; D016898:Interferon-alpha / Q000235:genetics; D008969:Molecular Sequence Data; D012330:RNA, Double-Stranded; D014780:Viruses
D007370:Interferon Type I; D016898:Interferon-alpha; D012330:RNA, Double-Stranded