title: Structure-activity relationships (SAR) of some tetracyclic heterocycles related to the immunosuppressive agent Brequinar Sodium.
abstract: The structure-activity relationships of some tetracyclic heterocycles related to Brequinar were explored. Activities as inhibitors of dihydroorotate dehydrogenase and the mixed lymphocyte reaction are related to ring system, heteroatom placement, and pendant ring substitution.
authors.affiliation: DuPont Merck Pharmaceutical Company, Wilmington, Delaware 19880-0500, USA.
authors.forename: W J
authors.initials: WJ
authors.lastname: Pitts
authors.forename: J W
authors.initials: JW
authors.lastname: Jetter
authors.forename: D J
authors.initials: DJ
authors.lastname: Pinto
authors.forename: M J
authors.initials: MJ
authors.lastname: Orwat
authors.forename: D G
authors.initials: DG
authors.lastname: Batt
authors.forename: S R
authors.initials: SR
authors.lastname: Sherk
authors.forename: J J
authors.initials: JJ
authors.lastname: Petraitis
authors.forename: I C
authors.initials: IC
authors.lastname: Jacobson
authors.forename: R A
authors.initials: RA
authors.lastname: Copeland
authors.forename: R L
authors.initials: RL
authors.lastname: Dowling
authors.forename: B D
authors.initials: BD
authors.lastname: Jaffee
authors.forename: T L
authors.initials: TL
authors.lastname: Gardner
authors.forename: E A
authors.initials: EA
authors.lastname: Jones
authors.forename: R L
authors.initials: RL
authors.lastname: Magolda
mesh_terms: D001713:Biphenyl Compounds / Q000737:chemistry*; D000090722:Dihydroorotate Dehydrogenase; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D006571:Heterocyclic Compounds / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000737:chemistry* / Q000494:pharmacology*; D007959:Lymphocyte Culture Test, Mixed; D010088:Oxidoreductases / Q000037:antagonists & inhibitors; D044925:Oxidoreductases Acting on CH-CH Group Donors; D013329:Structure-Activity Relationship; D011798:Quinaldines
chemical_list: D001713:Biphenyl Compounds; D000090722:Dihydroorotate Dehydrogenase; D004791:Enzyme Inhibitors; D006571:Heterocyclic Compounds; D007166:Immunosuppressive Agents; D010088:Oxidoreductases; D044925:Oxidoreductases Acting on CH-CH Group Donors; C046943:brequinar; D011798:Quinaldines