title: [Analgesic agents: comparative evaluation, mechanisms of action, prospects].
abstract: A classification of analgesics based on the localization and mechanisms of their action is proposed. Opioid analgesics are compared: opioid receptor agonists, agonists-antagonists, and partial agonists. Central-action nonopioid analgesics are listed: alpha 2-adrenomimetics, Na- and K-channel blockers, reverse monoamine neuronal capture inhibitors, stimulating amino acid antagonists, etc. Peripheral-action analgesics (cycloxygenase inhibitors) are described.
authors.forename: V V
authors.initials: VV
authors.lastname: Churiukanov
mesh_terms: D000700:Analgesics / Q000145:classification / Q000494:pharmacology; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology; D000701:Analgesics, Opioid / Q000494:pharmacology; D000928:Antidepressive Agents / Q000494:pharmacology; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D006801:Humans; D009020:Morphine / Q000494:pharmacology; D011957:Receptors, Opioid / Q000187:drug effects; D013116:Spinal Cord / Q000187:drug effects; D013997:Time Factors
chemical_list: D000700:Analgesics; D018712:Analgesics, Non-Narcotic; D000701:Analgesics, Opioid; D000928:Antidepressive Agents; D016861:Cyclooxygenase Inhibitors; D011957:Receptors, Opioid; D009020:Morphine
vernacular_title: Boleutoliaiushchie sredstva: sravnitel'naia otsenka, mekhanizmy deĭstviia, perspektivy.