title: Design and synthesis of analogs of vitamin E: antiproliferative activity against human breast adenocarcinoma cells.
abstract: Analogs of alpha-tocopherol (vitamin E; compounds 3-9) have been synthesized and tested for their antiproliferative activity using the human breast cancer cell line, MCF7. Compounds 6-9 were synthesized from a common symthom, rac-Trolox (14) and are soluble/miscible at physiological pH. Compounds 4, 8, and 9 were found to have antiproliferative activity at micromolar concentrations.
authors.affiliation: Steacie Institute for Molecular Sciences, National Research Council of Canada, Ottawa, Ontario.
authors.forename: P
authors.initials: P
authors.lastname: Arya
authors.forename: N
authors.initials: N
authors.lastname: Alibhai
authors.forename: H
authors.initials: H
authors.lastname: Qin
authors.forename: G W
authors.initials: GW
authors.lastname: Burton
authors.forename: G
authors.initials: G
authors.lastname: Batist
authors.forename: S X
authors.initials: SX
authors.lastname: You
authors.forename: M A
authors.initials: MA
authors.lastname: Alaoui-Jamali
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D001943:Breast Neoplasms / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects; D015195:Drug Design; D005260:Female; D006801:Humans; D008956:Models, Chemical; D014407:Tumor Cells, Cultured; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D014810:Vitamin E