Synthesis of benzanilide derivatives as dual acting agents with alpha 1-adrenoceptor antagonistic action and steroid 5-alpha reductase inhibitory activity.
Synthesis of benzanilide derivatives which have dual alpha 1-adrenoceptor antagonistic action and steroid 5 alpha-reductase inhibitory activity and their structure-activity relationships is described.
Yoshida
K
K
Central Research Laboratories, Zeria Pharmaceutical Co., Ltd., Saitama, Japan.
Horikoshi
Y
Y
Eta
M
M
Chikazawa
J
J
Ogishima
M
M
Fukuda
Y
Y
Sato
H
H
D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D000813:Anilides / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D042944:Cholestenone 5 alpha-Reductase; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D010088:Oxidoreductases / Q000037:antagonists & inhibitors*; D011817:Rabbits; D013329:Structure-Activity Relationship
D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists; D000813:Anilides; D004791:Enzyme Inhibitors; C034595:benzanilide; D010088:Oxidoreductases; D042944:Cholestenone 5 alpha-Reductase