title: Fabrication of multiunit controlled-release phenylpropanolamine hydrochloride tablets.
abstract: Phenylpropanolamine hydrochloride (PPA) pellets were prepared in a fluidized-bed rotary granulator. Microcrystalline cellulose and distilled water were used as pelletization enhancer and binder, respectively. The pellets were coated with methacrylate ester copolymer (Eudragit RS 100) solution containing a 1:1 ratio mixture of triethyl citrate and castor oil as plasticizers. The addition of approximately 30% microcrystalline cellulose and 2% croscarmellose sodium to the 50% coated pellets produced fast disintegrating tablets. Dissolution profiles of both pellets and their respective matrix tablets were comparable and conformed to the USP dissolution requirement for PPA extended-release capsules.
authors.affiliation: Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
authors.forename: A
authors.initials: A
authors.lastname: Mitrevej
authors.forename: N
authors.initials: N
authors.lastname: Sinchaipanid
authors.forename: N
authors.initials: N
authors.lastname: Natpoolwat
authors.forename: N
authors.initials: N
authors.lastname: Naratikornrit
mesh_terms: D003692:Delayed-Action Preparations; D004343:Drug Implants; D010665:Phenylpropanolamine / Q000493:pharmacokinetics*; D012995:Solubility; D013607:Tablets
chemical_list: D003692:Delayed-Action Preparations; D004343:Drug Implants; D013607:Tablets; D010665:Phenylpropanolamine