title: Effect of aminoguanidine on erythrocyte lipid peroxidation and activities of antioxidant enzymes in experimental diabetes.
abstract: The effect of aminoguanidine (AG) on the malondialdehyde (MDA) concentration and activities of superoxide dismutase (SOD), catalase and glutathione peroxidase (GSH-Px) in erythrocytes of rats with streptozotocin-induced diabetes was studied. Induction of diabetes resulted in an increase of MDA concentration and decreases of SOD and catalase activities after 6 and 12 weeks. GSH-Px activity increased after 6 weeks and returned to control values after 12 weeks. AG administration did not affect body weight, blood glucose level and HbA1c content in diabetic rats but led to a decrease of MDA concentration and SOD and catalase activities after 12 weeks of treatment, with no significant effect after 6 weeks. AG attenuated the GSH-Px increase after 6 weeks but augmented the activity of this enzyme after 12 weeks. These results confirm the presence of oxidative stress in streptozotocin-induced experimental diabetes and point to the beneficial antioxidant effect of AG.
authors.affiliation: Department of Internal Diseases, Military Medical University, Lódź, Poland.
authors.forename: K Z
authors.initials: KZ
authors.lastname: Kedziora-Kornatowska
authors.forename: M
authors.initials: M
authors.lastname: Luciak
authors.forename: J
authors.initials: J
authors.lastname: Blaszczyk
authors.forename: W
authors.initials: W
authors.lastname: Pawlak
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D002374:Catalase / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000201:enzymology; D004912:Erythrocytes / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000097:blood; D006442:Glycated Hemoglobin / Q000378:metabolism; D006146:Guanidines / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008315:Malondialdehyde / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D001786:Blood Glucose; D002374:Catalase; D005979:Glutathione Peroxidase; D006442:Glycated Hemoglobin; D006146:Guanidines; D008315:Malondialdehyde; D013311:Streptozocin; D013482:Superoxide Dismutase; C004479:pimagedine