PDE4 inhibitors: new xanthine analogues.
Novel xanthine analogues are described which are selective PDE4 inhibitors with improved therapeutic potential over theophylline.
Montana
J G
JG
Chiroscience Ltd, Cambridge Science Park, UK. johnmontana@chiroscience.com
Cooper
N
N
Dyke
H J
HJ
Gowers
L
L
Gregory
J P
JP
Hellewell
P G
PG
Miotla
J
J
Morris
K
K
Naylor
R
R
Tuladhar
B
B
Warneck
J B
JB
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000818:Animals; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D004802:Eosinophilia / Q000188:drug therapy; D005289:Ferrets; D006168:Guinea Pigs; D010726:Phosphodiesterase Inhibitors / Q000009:adverse effects / Q000138:chemical synthesis* / Q000494:pharmacology; D012871:Skin Diseases / Q000188:drug therapy; D013806:Theophylline / Q000494:pharmacology; D014839:Vomiting / Q000139:chemically induced; D014970:Xanthines / Q000138:chemical synthesis* / Q000494:pharmacology
D010726:Phosphodiesterase Inhibitors; D014970:Xanthines; D013806:Theophylline; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4