Presence of plasma endotoxin is correlated with tumour necrosis factor receptor levels and disease activity in alcoholic cirrhosis.
Cytokines and plasma endotoxin were measured in a consecutive series of patients with alcoholic cirrhosis (AC). Endotoxaemia was found to be strongly correlated to increased plasma levels of functionally active tumour necrosis factor (TNF) receptors -p55 and -p75, TNF-alpha and the Child-Pugh stage of the disease. Our data support the hypothesis of the pathogenic role of lipopolysaccharide in hepatocellular damage of patients with AC.
Hanck
C
C
Department of Internal Medicine IV (Gastroenterology), University Hospital of Heidelberg at Mannheim, Germany.
Rossol
S
S
Böcker
U
U
Tokus
M
M
Singer
M V
MV
D016022:Case-Control Studies; D004731:Endotoxins / Q000097:blood*; D005260:Female; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood* / Q000209:etiology; D008297:Male; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
D004731:Endotoxins; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha