Therapeutic effect of interstitial photodynamic therapy using ATX-S10(Na) and a diode laser on radio-resistant SCCVII tumors of C3H/He mice.
We examined the effect of interstitial photodynamic therapy (PDT) with a new photosensitizer ATX-S10(Na). This photosensitizer showed the strongest therapeutic effect 2-4 h after administration and was rapidly excreted from individual organs except tumor and liver 24 h after i.v. injection. Microscopic histofluorescent imaging showed fluorescence of ATX-S10(Na) in the cytoplasm of the tumor cells, but not in nuclei and in the vascular wall. Irradiation of Liniac 30 Gly+20 Gly slightly reduced the tumor size, but all mice died of relapse within 60 days after irradiation. In the PDT group, all tumors became non-palpable and healing was achieved in 50% of mice 120 days after PDT.
Nakajima
S
S
Division of Surgical Operation, Asahikawa Medical College, Japan.
Sakata
I
I
Hirano
T
T
Takemura
T
T
D000818:Animals; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D051379:Mice; D008809:Mice, Inbred C3H; D018307:Neoplasms, Squamous Cell / Q000188:drug therapy*; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000494:pharmacology*; D011166:Porphyrins / Q000627:therapeutic use*; D014407:Tumor Cells, Cultured
C117772:ATX S10Na(II); D017319:Photosensitizing Agents; D011166:Porphyrins