title: Predictive saccade behavior is enhanced in schizophrenia.
abstract: In this study, we investigated the ability of schizophrenic patients to produce predictive saccades in response to a visual target moving with predictable timing and location. The performance of visually guided saccades and predictive saccades (gain and latency) were analyzed in a group of 12 schizophrenic patients as compared with a group of ten control subjects. Our main finding was an enhancement of the predictive tracking ability in schizophrenics. In particular, the predictive tracking built-up and became installed as a steady pattern of highly anticipatory saccades (in terms of percentage of negative latency saccades) much faster in the schizophrenic group than in the control group. These data are discussed in terms of an involvement of the fronto-striatal system in this specific enhancement of predictive saccade behavior in schizophrenia.
authors.affiliation: Institut de Psychopathologie Cognitive et Neurobiologique, Université Lyon I), Hôpital du Vinatier, Lyon-Bron, France.
authors.forename: B
authors.initials: B
authors.lastname: Karoumi
authors.forename: J
authors.initials: J
authors.lastname: Ventre-Dominey
authors.forename: J
authors.initials: J
authors.lastname: Dalery
mesh_terms: D000328:Adult; D003342:Corpus Striatum / Q000503:physiopathology*; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D012438:Saccades / Q000502:physiology*; D012559:Schizophrenia / Q000503:physiopathology*