Interleukin-2 at different concentrations induces the growth of selective lymphoid cells.
The effects of low and high doses of recombinant interleukin-2 (rIL-2) on cultured peripheral blood mononucleated cells are reported with the aim to show the effects of this immunomodulator in different conditions. The proliferation of various cell types at different IL-2 concentrations was investigated and ultrastructural and enzymatic studies were performed. The data obtained indicate that grade and type of cell stimulation induced by IL-2 is correlated to the dose employed.
Capelli
E
Department of Genetics and Microbiology, University of Pavia, 27100 Pavia, Italy.
Nano
R
Civallero
M
Cerletti
M
Cremaschi
P
Nascimbene
C
Barni
S