title: New generation dopaminergic agents. 2. Discovery of 3-OH-phenoxyethylamine and 3-OH-N1-phenylpiperazine dopaminergic templates.
abstract: Described in this report is a systematic study which led to the identification of two new dopamine D2 partial agonists (5 and 17). Phenols 5 and 17 represent prototypes of two new classes of D2 partial agonists as well as templates for the future design of novel dopaminergic agents.
authors.affiliation: Global Chemical Sciences Department, Wyeth-Ayerst Research Laboratories, Princeton, New Jersey 08543-8000, USA.
authors.forename: R E
authors.initials: RE
authors.lastname: Mewshaw
authors.forename: M
authors.initials: M
authors.lastname: Husbands
authors.forename: E S
authors.initials: ES
authors.lastname: Gildersleeve
authors.forename: M B
authors.initials: MB
authors.lastname: Webb
authors.forename: X
authors.initials: X
authors.lastname: Shi
authors.forename: H
authors.initials: H
authors.lastname: Mazandarani
authors.forename: M I
authors.initials: MI
authors.lastname: Cockett
authors.forename: R
authors.initials: R
authors.lastname: Ochalski
authors.forename: J A
authors.initials: JA
authors.lastname: Brennan
authors.forename: M
authors.initials: M
authors.lastname: Abou-Gharbia
authors.forename: K
authors.initials: K
authors.lastname: Marquis
authors.forename: G B
authors.initials: GB
authors.lastname: McGaughey
authors.forename: J
authors.initials: J
authors.lastname: Coupet
authors.forename: T H
authors.initials: TH
authors.lastname: Andree
mesh_terms: D018491:Dopamine Agonists / Q000737:chemistry* / Q000494:pharmacology; D010636:Phenols / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D010879:Piperazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D017448:Receptors, Dopamine D2 / Q000819:agonists; D013329:Structure-Activity Relationship
chemical_list: C116737:3-(2-(benzylamino)ethoxy)phenol; C116738:4-benzyl-1-(3-hydroxyphenyl)piperzine; D018491:Dopamine Agonists; D010636:Phenols; D010879:Piperazines; D017448:Receptors, Dopamine D2