title: Potent and selective inhibitors of the proteasome: dipeptidyl boronic acids.
abstract: Potent and selective dipeptidyl boronic acid proteasome inhibitors are described. As compared to peptidyl aldehyde compounds, boronic acids in this series display dramatically enhanced potency. Compounds such as 15 are promising new therapeutics for treatment of cancer and inflammatory diseases.
authors.affiliation: ProScript, Inc., Cambridge, MA 02139, USA.
authors.forename: J
authors.initials: J
authors.lastname: Adams
authors.forename: M
authors.initials: M
authors.lastname: Behnke
authors.forename: S
authors.initials: S
authors.lastname: Chen
authors.forename: A A
authors.initials: AA
authors.lastname: Cruickshank
authors.forename: L R
authors.initials: LR
authors.lastname: Dick
authors.forename: L
authors.initials: L
authors.lastname: Grenier
authors.forename: J M
authors.initials: JM
authors.lastname: Klunder
authors.forename: Y T
authors.initials: YT
authors.lastname: Ma
authors.forename: L
authors.initials: L
authors.lastname: Plamondon
authors.forename: R L
authors.initials: RL
authors.lastname: Stein
mesh_terms: D001897:Boronic Acids / Q000737:chemistry / Q000494:pharmacology*; D003546:Cysteine Endopeptidases / Q000187:drug effects*; D015394:Molecular Structure; D009097:Multienzyme Complexes / Q000187:drug effects*; D011480:Protease Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D046988:Proteasome Endopeptidase Complex
chemical_list: D001897:Boronic Acids; D009097:Multienzyme Complexes; D011480:Protease Inhibitors; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex