[Surfactant-dependent atelectasis in pulmonary tuberculosis].
Using mathematic modelling of the secretion function of type II alveolocytes of the right lung intercellular surfactant production in treated and not treated rabbits with multi cavernous tuberculosis of the lung was evaluated. Correlation between its disorders and frequency of development and dissemination of atelectatic changes in the organ was revealed. Surfactant-dependent character of alveoli atelectasis in animals receiving a combination of antituberculosis drugs (isoniazide plus rifampycin plus etambutol), a direct effect of these drugs on membranes of the granular endoplasmic reticulum, formation of secretion granules was demonstrated. Daily intravenous administration of amboxol (25 mg/kg) for 14 days had a protective effect on type II alveolocytes, activated surfactant production, prevented alveoli from atelectasis.
Erokhin
V V
VV
Central Research Institute of Tuberculosis, Moscow.
Lepekha
L N
LN
D000818:Animals; D000995:Antitubercular Agents / Q000627:therapeutic use; D001261:Pulmonary Atelectasis / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D011663:Pulmonary Surfactants / Q000378:metabolism*; D011817:Rabbits; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*
D000995:Antitubercular Agents; D011663:Pulmonary Surfactants
Surfaktantzavisimyĭ atelektaz pri tuberkuleze legkikh.