Human herpesvirus 6 latently infects early bone marrow progenitors in vivo.
We have studied the in vivo tropism of human herpesvirus 6 (HHV-6) for hemopoietic cells in patients with latent HHV-6 infection. Having used a variety of cell purification, molecular, cytogenetic, and immunocytochemical procedures, we report the first evidence that HHV-6 latently infects early bone marrow progenitor cells and that HHV-6 may be transmitted longitudinally to cells which differentiate along the committed pathways.
Luppi
M
M
Section of Hematology, Department of Medical Sciences, University of Modena, Modena, Italy.
Barozzi
P
P
Morris
C
C
Maiorana
A
A
Garber
R
R
Bonacorsi
G
G
Donelli
A
A
Marasca
R
R
Tabilio
A
A
Torelli
G
G
D018952:Antigens, CD34 / Q000032:analysis; D001854:Bone Marrow Cells / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis; D006412:Hematopoietic Stem Cells / Q000821:virology*; D006566:Herpesviridae Infections / Q000821:virology*; D015654:Herpesvirus 6, Human / Q000502:physiology*; D006801:Humans; D016133:Polymerase Chain Reaction; D017735:Virus Latency
D018952:Antigens, CD34; D004279:DNA, Viral