title: Insulin-like growth factor system in serum and cerebrospinal fluid in patients with multiple sclerosis.
abstract: The insulin-like growth factor (IGF) system influences oligodendrocyte survival, myelination, and immune functions. We examined whether alterations in the circulating IGF system occur in multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the central nervous system. We measured concentrations of IGF-I, IGF-II, and insulin-like growth factor binding proteins -1, -2, and -3 in both serum and cerebrospinal fluid from MS patients and age- and sex-matched controls. IGFBP-1 was not detectable in cerebrospinal fluid. We found no significant differences in any of the other components between patients with MS and controls.
authors.affiliation: Department of Neurology, Academisch Ziekenhuis Groningen, The Netherlands.
authors.forename: N
authors.initials: N
authors.lastname: Wilczak
authors.forename: M
authors.initials: M
authors.lastname: Schaaf
authors.forename: R
authors.initials: R
authors.lastname: Bredewold
authors.forename: C
authors.initials: C
authors.lastname: Streefland
authors.forename: A
authors.initials: A
authors.lastname: Teelken
authors.forename: J
authors.initials: J
authors.lastname: De Keyser
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000097:blood* / Q000134:cerebrospinal fluid*; D013002:Somatomedins / Q000134:cerebrospinal fluid* / Q000378:metabolism*
chemical_list: D013002:Somatomedins