Toward a complete human genome sequence.
We have begun a joint program as part of a coordinated international effort to determine a complete human genome sequence. Our strategy is to map large-insert bacterial clones and to sequence each clone by a random shotgun approach followed by directed finishing. As of September 1998, we have identified the map positions of bacterial clones covering approximately 860 Mb for sequencing and completed >98 Mb ( approximately 3.3%) of the human genome sequence. Our progress and sequencing data can be accessed via the World Wide Web (http://webace.sanger.ac.uk/HGP/ or http://genome.wustl.edu/gsc/).
Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK;
Washington University School of Medicine, St. Louis, Missouri 63108 USA
D020451:Contig Mapping; D004247:DNA / Q000737:chemistry / Q000235:genetics*; D016208:Databases, Factual; D015894:Genome, Human; D015698:Genomic Library; D016045:Human Genome Project; D006801:Humans; D020407:Internet; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA / Q000379:methods
D004247:DNA