title: Scintigraphic localization of lymphatic leakage site after oral administration of iodine-123-IPPA.
abstract: Chylothorax can occur secondary to traumatic lesions of the thoracic duct caused by chest injuries, surgical procedures involving the pleural space, neoplasms or malformations of the lymphatics.
  
  
  METHODS
  Lymphatic leakage sites were localized by scintigraphy after oral administration of the 123I-labeled long-chain fatty acid derivative iodophenyl pentadecanoic acid (IPPA). We report on three patients with different lymphatic leakage sites and on one normal control subject.
  
  
  RESULTS
  IPPA scintigraphy localized the lymphatic leakage site correctly in all three patients. In two of them, the method even guided the successful surgical treatment of the leakage.
  
  
  CONCLUSIONS
  This approach is suitable for detecting lymphatic leakages of intestinal origin.
authors.affiliation: Clinic of Nuclear Medicine, University Hospital Charité, Humboldt University, Berlin, Germany.
authors.forename: B I
authors.initials: BI
authors.lastname: Kettner
authors.forename: R
authors.initials: R
authors.lastname: Aurisch
authors.forename: J C
authors.initials: JC
authors.lastname: Rückert
authors.forename: D
authors.initials: D
authors.lastname: Sandrock
authors.forename: D L
authors.initials: DL
authors.lastname: Munz
mesh_terms: D000284:Administration, Oral; D002648:Child; D002916:Chylothorax / Q000000981:diagnostic imaging*; D004938:Esophageal Neoplasms / Q000601:surgery; D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D007462:Iodobenzenes / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D008196:Lymph / Q000378:metabolism*; D008208:Lymphatic System / Q000002:abnormalities; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D010994:Pleura; D011183:Postoperative Complications; D011877:Radionuclide Imaging; D014062:Tongue Neoplasms / Q000601:surgery
chemical_list: D007457:Iodine Radioisotopes; D007462:Iodobenzenes; C025391:omega-(4-iodophenyl)pentadecanoic acid