[Two-site absorption model fits to pharmacokinetic data of gemfibrozil in man].
The plasma concentration-time data of gemfibrozil in 8 male subjects were determined after an oral dose of 600 mg. Two-peak concentrations in plasma were observed. A kind of one-compartment model with two-sites of drug absorption was proposed and used to fit these data. A good agreement between observed and predicted data was found in all subjects with correlation indexes (gamma 2) > 0.99. The corresponding pharmacokinetic parameters were estimated as follows: Tmax1, 1.10 +/- 0.46 h; Tmax2, 2.60 +/- 0.73 h; Cmax1, 13.62 +/- 4.30 micrograms.ml-1; Cmax2, 17.22 +/- 3.83 micrograms.ml-1; T1, 0.06 +/- 0.06 h; T2, 1.42 +/- 0.57 h and T3, 1.79 +/- 0.60 h.
Liu
X D
XD
Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing.
Xie
L
L
Wang
J
J
Zhou
Y S
YS
Wang
Z
Z
Liu
G Q
GQ
D000328:Adult; D005753:Gastric Mucosa / Q000378:metabolism; D015248:Gemfibrozil / Q000493:pharmacokinetics*; D006801:Humans; D000960:Hypolipidemic Agents / Q000493:pharmacokinetics*; D007408:Intestinal Absorption; D008297:Male; D008956:Models, Chemical
D000960:Hypolipidemic Agents; D015248:Gemfibrozil