title: Modulation of motor behaviour by NMDA- and cholecystokinin-antagonism.
abstract: Motor behaviour relies on complex neurochemical interactions in the basal ganglia, in particular the striatum. Antagonistic influences in this region are exerted by afferent projections from, on the one hand, the ventral mesencephalon, utilizing dopamine as a transmitter, and, on the other hand, from the cerebral cortex, signalling by the excitatory amino acid glutamate. The activity in both these neuronal populations appears to be regulated by the neuropeptide cholecystokinin. This article concentrates on interactions between cholecystokinin and glutamate, summarizing some recent morphological, biochemical and behavioural findings. It is suggested that cholecystokinin, acting via the cholecystokininB receptor, potentiates the glutamatergic excitatory input to the striatum.
authors.affiliation: Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
authors.forename: C
authors.initials: C
authors.lastname: Broberger
authors.forename: D
authors.initials: D
authors.lastname: Blacker
authors.forename: L
authors.initials: L
authors.lastname: Giménez-Llort
authors.forename: M
authors.initials: M
authors.lastname: Herrera-Marschitz
authors.forename: S O
authors.initials: SO
authors.lastname: Ogren
authors.forename: T
authors.initials: T
authors.lastname: Hökfelt
mesh_terms: D000818:Animals; D002766:Cholecystokinin / Q000378:metabolism / Q000502:physiology*; D003342:Corpus Striatum / Q000378:metabolism / Q000502:physiology; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D016202:N-Methylaspartate / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D043887:Receptor, Cholecystokinin B; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors / Q000502:physiology
chemical_list: D043887:Receptor, Cholecystokinin B; D011949:Receptors, Cholecystokinin; D016202:N-Methylaspartate; D002766:Cholecystokinin