title: The development of novel and selective p56lck tyrosine kinase inhibitors.
abstract: Early T-cell receptor mediated signal transduction involves the activation of several tyrosine protein kinases. One of these tyrosine kinases, p56lck, is expressed primarily in T-cells and Natural Killer (NK) cells and has been shown to be critical for their proliferative and effector functions. Indandiones have been identified as a potent and selective chemical class that inhibits p56lck.
authors.affiliation: R. W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.
authors.forename: J L
authors.initials: JL
authors.lastname: Bullington
authors.forename: J C
authors.initials: JC
authors.lastname: Cameron
authors.forename: J E
authors.initials: JE
authors.lastname: Davis
authors.forename: J H
authors.initials: JH
authors.lastname: Dodd
authors.forename: C A
authors.initials: CA
authors.lastname: Harris
authors.forename: J R
authors.initials: JR
authors.lastname: Henry
authors.forename: J L
authors.initials: JL
authors.lastname: Pellegrino-Gensey
authors.forename: K C
authors.initials: KC
authors.lastname: Rupert
authors.forename: J J
authors.initials: JJ
authors.lastname: Siekierka
mesh_terms: D000081247:CSK Tyrosine-Protein Kinase; D017868:Cyclic AMP-Dependent Protein Kinases / Q000037:antagonists & inhibitors; D004789:Enzyme Activation; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D007189:Indans / Q000737:chemistry / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000201:enzymology; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / Q000037:antagonists & inhibitors*; D008956:Models, Chemical; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000201:enzymology; D019061:src-Family Kinases
chemical_list: D004791:Enzyme Inhibitors; D007189:Indans; D011505:Protein-Tyrosine Kinases; D000081247:CSK Tyrosine-Protein Kinase; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck); D019061:src-Family Kinases; D017868:Cyclic AMP-Dependent Protein Kinases