[The peripheral blood levels of TNF alpha and PLA2 activities in dialysis and non-dialysis patients with uremia].
The levels of tumor necrosis factor a (TNF alpha) and phospholipase A2 (PLA2) in peripheral blood were determined by means of the ELISA and improved micromethod in 31 patients with urmia and 12 normal healthy persons. The results showed: 1. In non-dialysis group and during a single dialysis session, a significant increase in the levels of TNF alpha was observed. 2. In non-dialysis and peritoneal dialysis patients, serum levels of PLA2 were significantly increased compared to normal subjects. The results suggest that acute complications induced by hemodialysis are related to increasing levels of TNF alpha, souble PLA2 in cleared by hemodialysis.
Duan
S
S
Department of Medicine, Second Affiliated Hospital, Hunan Medical University, Changsha.
Luo
J
J
Liu
F
F
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis; D010741:Phospholipases A / Q000097:blood*; D054467:Phospholipases A2; D006435:Renal Dialysis; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D014511:Uremia / Q000097:blood* / Q000628:therapy
D014409:Tumor Necrosis Factor-alpha; D010741:Phospholipases A; D054467:Phospholipases A2