title: Inhibitors of the bacterial cell wall biosynthesis enzyme MurD.
abstract: A series of transition-state analog inhibitors of the D-glutamic acid-adding enzyme (MurD) of bacterial peptidoglycan biosynthesis has been synthesized and evaluated for inhibition of the E. coli enzyme.
authors.affiliation: Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA.
authors.forename: L D
authors.initials: LD
authors.lastname: Gegnas
authors.forename: S T
authors.initials: ST
authors.lastname: Waddell
authors.forename: R M
authors.initials: RM
authors.lastname: Chabin
authors.forename: S
authors.initials: S
authors.lastname: Reddy
authors.forename: K K
authors.initials: KK
authors.lastname: Wong
mesh_terms: D002473:Cell Wall / Q000201:enzymology*; D004926:Escherichia coli / Q000201:enzymology*; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000737:chemistry; D010453:Peptide Synthases / Q000037:antagonists & inhibitors* / Q000737:chemistry
chemical_list: D009943:Organophosphorus Compounds; D010453:Peptide Synthases; C053379:UDP-N-acetylmuramoylalanine-D-glutamate ligase