title: 99m Tc MIBI prone scintimammography in breast Paget's disease: a case report.
abstract: A 99m Tc MIBI prone scintimammography (PSM) was performed in a case of underlying Paget's disease of the breast. 99m Tc MIBI PSM showed a diffuse scintigraphic image like a spread of uptake from the deeply located zones of the breast toward epidermis. In vivo, 99m Tc MIBI PSM represents the spread of neoplastic Paget's cells probably attracted by chemotactic factors released by keratinocytes. This spread in Paget's disease is correlated to neu oncogene overexpression which increases the metastatic activity as a consequence of motility enhancement and growth stimulation effect. These scintigraphic images suggest that 99m Tc MIBI PSM could be relevant in management of Paget's disease of the breast.
authors.affiliation: Servizio Speciale di Oncologia, Dipartimento di Medicina Sperimentale e Patologia, I-00161 Rome, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Mezi
authors.forename: F
authors.initials: F
authors.lastname: Scopinaro
authors.forename: A
authors.initials: A
authors.lastname: Marzullo
authors.forename: E
authors.initials: E
authors.lastname: Sallusti
authors.forename: V
authors.initials: V
authors.lastname: David
authors.forename: M
authors.initials: M
authors.lastname: Ierardi
authors.forename: N S
authors.initials: NS
authors.lastname: Tiberio
authors.forename: M
authors.initials: M
authors.lastname: Modesti
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging*; D002278:Carcinoma in Situ / Q000175:diagnosis*; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis*; D002630:Chemotactic Factors / Q000378:metabolism; D004817:Epidermis / Q000473:pathology; D005260:Female; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism; D008327:Mammography; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000032:analysis; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis*; D014411:Neoplastic Stem Cells / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology; D010144:Paget's Disease, Mammary / Q000737:chemistry / Q000000981:diagnostic imaging*; D016684:Prone Position; D011877:Radionuclide Imaging; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D017256:Technetium Tc 99m Sestamibi; D014463:Ultrasonography
chemical_list: D014408:Biomarkers, Tumor; D002630:Chemotactic Factors; D009363:Neoplasm Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases; D017256:Technetium Tc 99m Sestamibi