[Effects of modifications of lipoproteins by water soluble forms of lineoleic-hydroxamic acid on biochemical markers of development of atherosclerosis].
Effects of water-soluble form of linoleic-hydroxamic acid, inhibitor of lipoxygenase, on process of atherogenesis (alimentary model) were studied at rabbits. It was shown that inhibition of activity of lipoxygenase during process of development of atherosclerosis led to considerable decrease of area of lipoid plaques and lipoidosis, decreased content of cholesterol in blood and improved free-radical modification of lipoproteins of blood.
Chobot'ko
H M
HM
Scientific Centre of Radiation Medicin of AMS of Ukraine, Kyiv.
D000818:Animals; D001161:Arteriosclerosis / Q000378:metabolism*; D015415:Biomarkers; D002784:Cholesterol / Q000097:blood; D005609:Free Radicals; D006877:Hydroxamic Acids / Q000627:therapeutic use*; D019787:Linoleic Acid / Q000627:therapeutic use*; D008074:Lipoproteins / Q000378:metabolism*; D016859:Lipoxygenase Inhibitors / Q000627:therapeutic use*; D008297:Male; D011817:Rabbits; D012995:Solubility; D014867:Water / Q000737:chemistry
D015415:Biomarkers; D005609:Free Radicals; D006877:Hydroxamic Acids; D008074:Lipoproteins; D016859:Lipoxygenase Inhibitors; D014867:Water; D002784:Cholesterol; D019787:Linoleic Acid
Vplyv modyfikatsiï lipoproteïniv vodorozchynnoiu formoiu linoleïlgidroksamovoï kysloty na biokhimichni markery razvytku aterosklerozu.