title: Gastric accommodation in non-ulcer dyspepsia and the roles of Helicobacter pylori infection and vagal function.
abstract: BACKGROUND
  The pathophysiological mechanisms in non-ulcer dyspepsia are incompletely understood.
  
  
  OBJECTIVE
  To compare gastric motor and sensory functions in Helicobacter pylori positive or negative patients with non-ulcer dyspepsia.
  
  
  METHODS
  Seventeen patients with non-ulcer dyspepsia and 16 asymptomatic controls.
  
  
  METHODS
  The following were evaluated: gastrointestinal symptoms; gastric emptying and orocaecal transit of solids; abdominal vagal function; gastric compliance; fasting and postprandial gastric tone and phasic contractions; symptoms during ingestion of cold water and during the distension of an intragastric bag; and somatic sensitivity and personality profile (Minnesota Multiphasic Personality Inventory, MMPI).
  
  
  RESULTS
  Gastric accommodation was reduced in H pylori negative dyspeptics relative to controls; the degree of accommodation was unrelated to H pylori status in dyspeptics. Increased postprandial gastric sensation was more frequent among H pylori positive patients (4/5 H pylori positive versus 4/12 H pylori negative patients). Intragastric meal distribution and orocaecal transit were normal; gastric emptying at four hours was abnormal in 4/17 patients. Vagal dysfunction was rare. Eight of 17 patients had somatisation or depression on MMPI.
  
  
  CONCLUSIONS
  Impaired gastric accommodation is frequent in non-ulcer dyspepsia and seems to be unrelated to vagal efferent dysfunction. H pylori infection does not seem to influence gastric accommodation, but is associated with heightened sensitivity in dyspeptics. Therapeutic approaches that restore normal postprandial accommodation and gastric sensitivity should be tested in non-ulcer dyspepsia.
authors.affiliation: Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA.
authors.forename: M
authors.initials: M
authors.lastname: Thumshirn
authors.forename: M
authors.initials: M
authors.lastname: Camilleri
authors.forename: S B
authors.initials: SB
authors.lastname: Saslow
authors.forename: D E
authors.initials: DE
authors.lastname: Williams
authors.forename: D D
authors.initials: DD
authors.lastname: Burton
authors.forename: R B
authors.initials: RB
authors.lastname: Hanson
mesh_terms: D000328:Adult; D003187:Compliance; D004415:Dyspepsia / Q000382:microbiology / Q000503:physiopathology*; D005260:Female; D005746:Gastric Emptying / Q000502:physiology; D005772:Gastrointestinal Transit / Q000502:physiology; D016481:Helicobacter Infections / Q000150:complications / Q000503:physiopathology*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D012677:Sensation; D013270:Stomach / Q000503:physiopathology*; D014630:Vagus Nerve / Q000503:physiopathology*