Veno-occlusive disease of the liver in right-sided Wilms' tumours.
Veno-occlusive disease of the liver (VOD) is an important complication in children with Wilms' tumour. Although in most patients this complication resolves uneventfully, fatal cases have been reported. Several observations strongly suggest that actinomycin-D is the likeliest cause of VOD in Wilms' tumour, but VOD seems to be rather uncommon in other malignancies treated with chemotherapy including actinomycin-D. The present case of VOD and the review of the literature stress the pathogenetic and clinical implications of VOD in the presence of a Wilms' tumour treated with actinomycin-D, originating in the right kidney. Greater awareness of this 'predisposing factor' may alert paediatricians to the presence of minimal signs of the syndrome.
Tornesello
A
A
Division of Paediatric Oncology, Catholic University, Rome, Italy.
Piciacchia
D
D
Mastrangelo
S
S
Lasorella
A
A
Mastrangelo
R
R
D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D002675:Child, Preschool; D003609:Dactinomycin / Q000009:adverse effects*; D006504:Hepatic Veno-Occlusive Disease / Q000139:chemically induced*; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy*; D008111:Liver Function Tests; D008297:Male; D009396:Wilms Tumor / Q000188:drug therapy*
D000903:Antibiotics, Antineoplastic; D003609:Dactinomycin