title: SAR studies of diaryltriazoles against bacterial two-component regulatory systems and their antibacterial activities.
abstract: A series of diaryltriazole analogs was discovered to inhibit bacterial two-component regulatory systems in our primary assays, KinA/Spo0F and NRII/NRI. They also showed inhibitory activity in whole cell mechanism-based assays, and they possessed potent activities against several strains of Gram-positive pathogenic bacteria in the standard MIC broth assay.
authors.affiliation: R. W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.
authors.forename: Z
authors.initials: Z
authors.lastname: Sui
authors.forename: J
authors.initials: J
authors.lastname: Guan
authors.forename: D J
authors.initials: DJ
authors.lastname: Hlasta
authors.forename: M J
authors.initials: MJ
authors.lastname: Macielag
authors.forename: B D
authors.initials: BD
authors.lastname: Foleno
authors.forename: R M
authors.initials: RM
authors.lastname: Goldschmidt
authors.forename: M J
authors.initials: MJ
authors.lastname: Loeloff
authors.forename: G C
authors.initials: GC
authors.lastname: Webb
authors.forename: J F
authors.initials: JF
authors.lastname: Barrett
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D014230:Triazoles