title: Problems with parsimony in sequences of biased base composition.
abstract: Parsimony is commonly used to infer the direction of substitution and mutation. However, it is known that parsimony is biased when the base composition of the DNA sequence is skewed. Here I quantify this effect for several simple cases. The analysis demonstrates that parsimony can be misleading even when levels of sequence divergence are as low as 10%; parsimony incorrectly infers an excess of common to rare changes. Caution must therefore be excercised in the use of parsimony.
authors.affiliation: Centre for the Study of Evolution & School of Biological Sciences, University of Sussex, Brighton BN1 9QG, UK. a.c.eyre-walker@sussex.ac.uk
authors.forename: A
authors.initials: A
authors.lastname: Eyre-Walker
mesh_terms: D001482:Base Composition; D015982:Bias; D004247:DNA / Q000737:chemistry / Q000235:genetics; D019143:Evolution, Molecular; D008957:Models, Genetic; D009154:Mutation
chemical_list: D004247:DNA