Molecular mimicry in chronic inflammatory demyelinating polyneuropathy and melanoma.
Polyclonal immunoglobulin M antibodies to the monosialoganglioside GM2, sulfoglucuronyl glycolipids, and sulfatide were detected by thin-layer chromatography and enzyme-linked immunosorbent assay in the serum of a patient with melanoma and chronic inflammatory demyelinating polyneuropathy. Both the patient's serum and polyclonal antibodies against GM2 reacted strongly with a biopsy of melanomatous tissue from the patient, suggesting a process of molecular mimicry.
Weiss
M D
MD
Laboratory of Molecular and Cellular Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Luciano
C A
CA
Semino-Mora
C
C
Dalakas
M C
MC
Quarles
R H
RH
D000368:Aged; D000918:Antibody Specificity; D002908:Chronic Disease; D003711:Demyelinating Diseases / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005677:G(M1) Ganglioside / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008545:Melanoma / Q000276:immunology*; D018716:Molecular Mimicry; D018992:Myelin-Associated Glycoprotein / Q000737:chemistry / Q000276:immunology; D011115:Polyneuropathies / Q000276:immunology*
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D018992:Myelin-Associated Glycoprotein; D005677:G(M1) Ganglioside