[Clinical observation on effect of xiaoyu zhixue tablet on 104 patients with idiopathic multifocal bleeding and platelet aggregation defect].
OBJECTIVE
To explore the effect and pharmacological mechanism of Xiaoyu Zhixue Tablet (XZT).


METHODS
The XZT mainly composed of Chinese medicinal herbs to replenishing Qi and removing stasis was used to treat patients with idiopathic multifocal bleeding and platelet aggregation defect. Patients were divided into 2 groups. The TCM group (104 cases) treated with XZT, and the control group (84 cases) treated with vitamins C, K and P, adrenosin and (or) artificial menstruation, for at least 4 months.


RESULTS
The hemostatic effective rate was 92.3% in TCM group and 27.4% in control group (P < 0.005), the recovery rate of platelet aggregation after 6 months therapy was 69.2% and only 1.8% respectively. The difference between two groups was very significant (P < 0.005).


CONCLUSIONS
XZT could regulate the physiological functions of blood-vessel and platelet to realize the hemostatic action and platelet aggregation.
Shen
D
D
Xiehe Hospital, Tongji Medical University, Wuhan.
Shen
L
L
Wang
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AL
D000293:Adolescent; D000328:Adult; D002648:Child; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006470:Hemorrhage / Q000188:drug therapy*; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D013607:Tablets
D004365:Drugs, Chinese Herbal; D006490:Hemostatics; D013607:Tablets