Screening and isolation of antibiotic resistance inhibitors from herb materials IV-resistance inhibitors from Anetheum graveolens and Acorus gramineus.
The hexane fractions from methanolic extracts of Anetheum graveolens L. (Umbelliferae) and Acorus gramineus Soland. (Araceae), revealed potent inhibitory activities against the resistance of multi-drug resistant Staphylococcus aureus SA2 when combined with ampicillin (Am) or chloramphenicol (Cm). As active principles, carvone and the liquid mixture containing carvone from Anetheum graveolens L. and a liquid mixture mainly consisting of benzoic acid phenylmethyl ester (benzyl benzoate) from Acorus gramineus Soland, were identified. They showed resistance inhibition at the level of 20-50 micrograms/ml when combined with 100 or 50 micrograms/ml of Am or Cm, respectively.
Kim
H
H
College of Pharmacy, Kyungsung University, Pusan, Korea.
Moon
K H
KH
Ryu
S Y
SY
Moon
D C
DC
Lee
C K
CK
D000667:Ampicillin / Q000494:pharmacology; D000668:Ampicillin Resistance; D019661:Apiaceae / Q000737:chemistry*; D001565:Benzoates / Q000494:pharmacology; D002478:Cells, Cultured; D002701:Chloramphenicol / Q000494:pharmacology; D002702:Chloramphenicol Resistance; D000081005:Cyclohexane Monoterpenes; D004352:Drug Resistance, Microbial; D019684:Magnoliopsida / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D039821:Monoterpenes; D013211:Staphylococcus aureus / Q000187:drug effects; D013729:Terpenes / Q000494:pharmacology
D001565:Benzoates; D000081005:Cyclohexane Monoterpenes; D039821:Monoterpenes; D013729:Terpenes; D002701:Chloramphenicol; C006923:carvone; D000667:Ampicillin; C006723:benzyl benzoate