title: Reversal of "no reflow" during vein graft stenting using high velocity boluses of intracoronary adenosine.
abstract: Slow or no reflow is a serious problem complicating catheter-based revascularization of degenerated saphenous vein bypass grafts. We examined the efficacy of rapidly delivered, high-velocity injections of intracoronary adenosine to reverse 11 slow-flow events complicating stenting of diseased bypass grafts. Ten of 11 events were rapidly improved to TIMI 3 flow by this technique within 3.8+/-1.6 min of the initial adenosine injection. In an ex vivo model, 3-ml syringes created higher peak pressures and velocities than 10- and 20-ml syringes. We conclude that rapid and repeated high-velocity intragraft administration of adenosine is a promising new approach to promptly reverse no-reflow events complicating PTCA and stenting of diseased saphenous vein grafts. Ex vivo studies demonstrate a potentially important mechanical advantage with the use of small syringes for injection. Further randomized studies will be required to better define the mechanism(s) and efficacy of this approach for treating no reflow, including its use in native vessels.
authors.affiliation: Michigan State University, Heart Institute at Borgess Medical Center, Kalamazoo 49001, USA. taf1@net-link.net
authors.forename: T A
authors.initials: TA
authors.lastname: Fischell
authors.forename: A J
authors.initials: AJ
authors.lastname: Carter
authors.forename: M T
authors.initials: MT
authors.lastname: Foster
authors.forename: K
authors.initials: K
authors.lastname: Hempsall
authors.forename: J
authors.initials: J
authors.lastname: DeVries
authors.forename: D H
authors.initials: DH
authors.lastname: Kim
authors.forename: A
authors.initials: A
authors.lastname: Kloostra
mesh_terms: D000241:Adenosine / Q000008:administration & dosage* / Q000627:therapeutic use; D015906:Angioplasty, Balloon, Coronary; D017023:Coronary Angiography; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000601:surgery; D003331:Coronary Vessels / Q000502:physiology; D006083:Graft Occlusion, Vascular / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007269:Injections, Intra-Arterial; D010865:Pilot Projects; D012039:Regional Blood Flow / Q000187:drug effects; D012501:Saphenous Vein / Q000637:transplantation; D015607:Stents; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D014665:Vasodilator Agents; D000241:Adenosine