title: N-[4-(1,1'-biphenyl)methyl]-4-(4-thiomorpholinylmethyl) benzenamines as non-oxazolidinone analogues of antimycobacterial U-100480.
abstract: Thiomorpholine analogues of U-100480 with the biphenylmethyl group replacing the acetamidomethyloxazolidinone moiety have been synthesized and tested as antimycobacterial agents together with various related derivatives. Some biphenyl derivatives were endowed with high activity against Mycobacterium tuberculosis and other non-tuberculous mycobacteria.
authors.affiliation: Dipartimento di Studi Farmaceutici, Università di Roma La Sapienza, Italy. artico@uniromal.it
authors.forename: M
authors.initials: M
authors.lastname: Artico
authors.forename: A
authors.initials: A
authors.lastname: Mai
authors.forename: G
authors.initials: G
authors.lastname: Sbardella
authors.forename: S
authors.initials: S
authors.lastname: Massa
authors.forename: G
authors.initials: G
authors.lastname: Lampis
authors.forename: D
authors.initials: D
authors.lastname: Deidda
authors.forename: R
authors.initials: R
authors.lastname: Pompei
mesh_terms: D000081:Acetamides / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects*; D010080:Oxazoles / Q000737:chemistry / Q000494:pharmacology*; D013045:Species Specificity; D014709:Vero Cells
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D010080:Oxazoles; C098012:U 100480