title: Tripeptide growth hormone secretagogues.
abstract: A series of C-terminus capped dipeptides and tripeptides was synthesized as growth hormone (GH) secretagogues. Among them, tripeptide Aib-D-Trp-D-homoPhe-OEt showed low nanomolar activity in the rat pituitary assay. Thus, we have demonstrated that the GH secretagogue activity of the hexa-hepta-GH releasing peptides can be mimicked at the tripeptide level.
authors.affiliation: Department of Medicinal Chemistry, and Biochemistry & Physiology, Merck Research Laboratories, Rahway, NJ 07065, USA.
authors.forename: L
authors.initials: L
authors.lastname: Yang
authors.forename: G
authors.initials: G
authors.lastname: Morriello
authors.forename: Y
authors.initials: Y
authors.lastname: Pan
authors.forename: R P
authors.initials: RP
authors.lastname: Nargund
authors.forename: K
authors.initials: K
authors.lastname: Barakat
authors.forename: K
authors.initials: K
authors.lastname: Prendergast
authors.forename: K
authors.initials: K
authors.lastname: Cheng
authors.forename: W W
authors.initials: WW
authors.lastname: Chan
authors.forename: R G
authors.initials: RG
authors.lastname: Smith
authors.forename: A A
authors.initials: AA
authors.lastname: Patchett
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004151:Dipeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013006:Growth Hormone / Q000378:metabolism*; D066298:In Vitro Techniques; D008958:Models, Molecular; D015394:Molecular Structure; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010902:Pituitary Gland / Q000378:metabolism; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D004151:Dipeptides; D009842:Oligopeptides; C079956:alanyl-histidyl-(2-naphthyl)alanyl-tryptophyl-phenylalanyl-lysinamide; C041048:growth hormone releasing hexapeptide; D013006:Growth Hormone; C091874:growth hormone-releasing peptide-2