title: Novel cytokine release inhibitors. Part I: Triterpenes.
abstract: Tripterine and closely related triterpenoid derivatives as IL-1 beta release inhibitors are discussed.
authors.affiliation: Department of Medicinal Chemistry, Rhóne-Poulenc Rorer Central Research, Collegeville, PA 19426, USA.
authors.forename: F C
authors.initials: FC
authors.lastname: Huang
authors.forename: W K
authors.initials: WK
authors.lastname: Chan
authors.forename: K J
authors.initials: KJ
authors.lastname: Moriarty
authors.forename: D C
authors.initials: DC
authors.lastname: Zhang
authors.forename: M N
authors.initials: MN
authors.lastname: Chang
authors.forename: W
authors.initials: W
authors.lastname: He
authors.forename: K T
authors.initials: KT
authors.lastname: Yu
authors.forename: A
authors.initials: A
authors.lastname: Zilberstein
mesh_terms: D000818:Animals; D016207:Cytokines / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007249:Inflammation / Q000378:metabolism / Q000517:prevention & control; D015394:Molecular Structure; D051381:Rats; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D016207:Cytokines; D014315:Triterpenes