title: Carbocyclic frenolicin analogues: novel anticoccidial agents.
abstract: Carbocyclic analogues of the antibacterial natural product frenolicin B have been synthesised. These analogues were active against parasitic protozoa of the genus Eimeria and represent a new series of anticoccidial agents. The synthesis of simplified analogues helped to define a possible pharmacophore for frenolicin.
authors.affiliation: Pfizer Central Research, Sandwich, Kent.
authors.forename: R E
authors.initials: RE
authors.lastname: Armer
authors.forename: C J
authors.initials: CJ
authors.lastname: Dutton
authors.forename: B R
authors.initials: BR
authors.lastname: Fenner
authors.forename: S D
authors.initials: SD
authors.lastname: Greenwood
authors.forename: K T
authors.initials: KT
authors.lastname: Hall
authors.forename: A J
authors.initials: AJ
authors.lastname: Rudge
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D003048:Coccidiosis / Q000188:drug therapy*; D004539:Eimeria / Q000187:drug effects; D009285:Naphthoquinones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D000095622:Benzoisochromanequinones
chemical_list: D000981:Antiprotozoal Agents; D009285:Naphthoquinones; C018066:frenolicin B; D000095622:Benzoisochromanequinones