title: [The effect of chemotherapy on bone metabolism in patients with non-small cell lung cancer].
abstract: In this study the influence of chemotherapy on bone metabolism in patients with III stage of non-small cell lung cancer has been evaluated. 30 patients (men) in average age 57.1 years were enrolled to this trial. The trial carried out on 2 groups of patients: group A consisted of 30 patients with NSCLC, group B of 15 patients without neoplastic process. In all participants bone scintigraphy was done and the following biochemical markers were measured: osteocalcin concentration, alkaline phosphatase's bone fraction, twenty-four-hour calcium and hydroxyproline urine excretion. In patients after two courses of chemotherapy (mitomycin, cisplatin, vinblastine) statistically significant reduction of serum concentration of osteocalcin, alkaline phosphatase, also reduction of calcium and hydroxyproline urine excretion have been observed. Scintigraphic examination of bones showed statistically significant decrease in resorption of isotope (MDP 99mTc) in patients after chemotherapy (p < 0.05).
  
  
  CONCLUSIONS
  The study shows positive influence of chemotherapy on bone metabolism in patients with NSCLC. Patients treated with chemotherapy have bone metastases less frequently.
authors.affiliation: Kliniki Pneumonologii Instytutu Chorób Wewnetrznych.
authors.forename: M
authors.initials: M
authors.lastname: Kołaczkowska
authors.forename: R
authors.initials: R
authors.lastname: Junik
authors.forename: M
authors.initials: M
authors.lastname: Rzymkowska
authors.forename: L
authors.initials: L
authors.lastname: Kramer
mesh_terms: D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000517:prevention & control* / Q000556:secondary; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000378:metabolism; D002118:Calcium / Q000652:urine; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000378:metabolism / Q000556:secondary; D002945:Cisplatin / Q000008:administration & dosage; D006801:Humans; D006909:Hydroxyproline / Q000652:urine; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D008937:Mitomycins / Q000008:administration & dosage; D015675:Osteocalcin / Q000097:blood; D011877:Radionuclide Imaging; D014747:Vinblastine / Q000008:administration & dosage
chemical_list: D008937:Mitomycins; D015675:Osteocalcin; D014747:Vinblastine; D000469:Alkaline Phosphatase; D002945:Cisplatin; D006909:Hydroxyproline; D002118:Calcium
vernacular_title: Wpływ chemioterapii na metabolizm kostny u chorych na niedrobnokomórkowego raka płuca.