Effect of captopril on proliferation of aortic smooth muscle cells.
OBJECTIVE
To study the effect of captopril (Cap) on proliferation of smooth muscle cells (SMC).


METHODS
Proliferation of cultured porcine aortic SMC was promoted by hyperlipidemic sera (HLS).


RESULTS
Cap (0.2 mg.L-1) remarkably reduced [3H]thymidine ([3H]TdR) incorporation, inhibited DNA synthesis and proliferation of SMC, and lessened morphological changes caused by HLS. After administration of Cap, malondialdehyde (MDA) content and plasminogen activator inhibitor (PAI) activity were reduced, 6-keto-PGF1 alpha and cAMP contents were obviously increased (P < 0.05-0.01).


CONCLUSIONS
Cap inhibited the proliferation of SMC, associated with MDA, PAI, 6-keto-PGF1 alpha and cAMP.
Xiong
Y L
YL
Department of Medicine, Tongji Hospital, Tongji Medical University, Wuhan, China.
Zhao
H Y
HY
D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D001013:Aorta, Thoracic / Q000166:cytology; D002216:Captopril / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D017077:Culture Media, Conditioned; D008315:Malondialdehyde / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000166:cytology* / Q000378:metabolism; D015849:Plasminogen Inactivators / Q000378:metabolism; D013552:Swine
D000806:Angiotensin-Converting Enzyme Inhibitors; D017077:Culture Media, Conditioned; D015849:Plasminogen Inactivators; D008315:Malondialdehyde; D015121:6-Ketoprostaglandin F1 alpha; D002216:Captopril