title: Induced hypothermia in the postoperative management of refractory cardiac failure following paediatric cardiac surgery.
abstract: Postoperative low cardiac output states are a major cause of postoperative mortality in infants and children following corrective cardiac surgery for congenital heart defects. In this unit, whole body hypothermia has been used since 1979 in the management of these low output states when they are refractory to conventional modes of therapy. Twenty cases treated in this way between July 1986 and June 1990 were reviewed in 1992. The current report reviews the 50 further cases treated with moderate hypothermia between July 1990 and December 1995. The median (range) age of patients was 8 months (0 days-16 years) with a median weight of 4.1 kg (2.5-33 kg). Following cooling, there was a decrease in heart rate (p < 0.001), an increase in mean arterial pressure (p < 0.001) and a decrease in mean atrial pressure (p < 0.001). Significant increases in pH and urine output were also noticed, the increase in urine output being greater in the surviving group (p = 0.02). A decrease in platelet count occurred (p < 0.001) but white blood cell count remained unchanged (p = 0.18). Twenty-five of the 50 patients survived to leave hospital. Induced hypothermia does not appear to be associated with any complications and after the failure of all conventional treatment, it seems likely that the technique may have been beneficial to outcome in some patients.
authors.affiliation: Department of Anaesthetics, Wessex Cardiothoracic Centre, Southampton General Hospital, UK.
authors.forename: C D
authors.initials: CD
authors.lastname: Deakin
authors.forename: H
authors.initials: H
authors.lastname: Knight
authors.forename: J C
authors.initials: JC
authors.lastname: Edwards
authors.forename: J L
authors.initials: JL
authors.lastname: Monro
authors.forename: R K
authors.initials: RK
authors.lastname: Lamb
authors.forename: B
authors.initials: B
authors.lastname: Keeton
authors.forename: A P
authors.initials: AP
authors.lastname: Salmon
mesh_terms: D000293:Adolescent; D002303:Cardiac Output, Low / Q000097:blood / Q000628:therapy* / Q000652:urine; D002648:Child; D002675:Child, Preschool; D006330:Heart Defects, Congenital / Q000601:surgery*; D006439:Hemodynamics; D017052:Hospital Mortality; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007036:Hypothermia, Induced; D007223:Infant; D007231:Infant, Newborn; D007958:Leukocyte Count; D010976:Platelet Count; D011182:Postoperative Care / Q000379:methods*; D011183:Postoperative Complications / Q000097:blood / Q000628:therapy* / Q000652:urine; D011184:Postoperative Period; D012189:Retrospective Studies