title: Glucose plus insulin infusion improves cerebral outcome after asphyxial cardiac arrest.
abstract: Hyperglycemia before ischemia worsens cerebral outcome. The aim of this study was to determine the cerebral effects of giving glucose with or without insulin after asphyxial cardiac arrest. Rats underwent 8 min of asphyxial cardiac arrest. After arrest, Group 1 received NaCl; Group 2, insulin; Group 3, glucose; and Group 4, glucose plus insulin, all intravenously. Neurological deficit (ND) scores were 14+/-10%, 22+/-12%, 12+/-10% and 2+/-2% in Groups 1-4, respectively, 72 h after reperfusion. Overall histological damage (HD) scores were 4, 2, 3 and 1, respectively. Group 4 fared significantly better than group 1 on both scores. Glucose after asphyxial cardiac arrest in rats produces no increased brain damage while glucose plus insulin improves cerebral outcome.
authors.affiliation: Department of Anesthesiology, Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, USA.
authors.forename: L M
authors.initials: LM
authors.lastname: Katz
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: U
authors.initials: U
authors.lastname: Ebmeyer
authors.forename: A
authors.initials: A
authors.lastname: Radovsky
authors.forename: P
authors.initials: P
authors.lastname: Safar
mesh_terms: D000818:Animals; D001237:Asphyxia / Q000188:drug therapy* / Q000503:physiopathology; D001786:Blood Glucose; D001794:Blood Pressure; D001921:Brain / Q000098:blood supply / Q000378:metabolism; D016887:Cardiopulmonary Resuscitation; D005947:Glucose / Q000494:pharmacology*; D006323:Heart Arrest; D006863:Hydrogen-Ion Concentration; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D002534:Hypoxia, Brain / Q000188:drug therapy* / Q000503:physiopathology; D007328:Insulin / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D005947:Glucose