Interleukin-10: potential benefits and possible risks in clinical infectious diseases.
Human interleukin-10 (IL-10) is a potent anti-inflammatory cytokine that inhibits the synthesis of the major proinflammatory cytokines and chemokines. IL-10 is the principal TH2-type cytokine that upregulates humoral immune responses and attenuates cell-mediated immune reactions. This cytokine has a number of immunomodulatory properties that might be clinically useful in a variety of inflammatory and infectious disease states. Clinical trials with human recombinant IL-10 are already in progress. Carefully selected patients with inflammatory conditions may benefit from IL-10 therapy if concomitant infectious diseases are recognized and treated appropriately.
Opal
S M
SM
Infectious Disease Division, Brown University School of Medicine, Providence, Rhode Island, USA.
Wherry
J C
JC
Grint
P
P
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D003141:Communicable Diseases / Q000188:drug therapy; D019446:Endotoxemia / Q000188:drug therapy; D006801:Humans; D016753:Interleukin-10 / Q000627:therapeutic use*; D051379:Mice; D018123:Receptors, Interleukin / Q000096:biosynthesis; D053701:Receptors, Interleukin-10
D000276:Adjuvants, Immunologic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D018123:Receptors, Interleukin; D053701:Receptors, Interleukin-10; D016753:Interleukin-10