N-[4-(1,1'-biphenyl)methyl]-4-(4-thiomorpholinylmethyl) benzenamines as non-oxazolidinone analogues of antimycobacterial U-100480.
Thiomorpholine analogues of U-100480 with the biphenylmethyl group replacing the acetamidomethyloxazolidinone moiety have been synthesized and tested as antimycobacterial agents together with various related derivatives. Some biphenyl derivatives were endowed with high activity against Mycobacterium tuberculosis and other non-tuberculous mycobacteria.
Artico
M
M
Dipartimento di Studi Farmaceutici, Università di Roma La Sapienza, Italy. artico@uniromal.it
Mai
A
A
Sbardella
G
G
Massa
S
S
Lampis
G
G
Deidda
D
D
Pompei
R
R
D000081:Acetamides / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects*; D010080:Oxazoles / Q000737:chemistry / Q000494:pharmacology*; D013045:Species Specificity; D014709:Vero Cells
D000081:Acetamides; D000900:Anti-Bacterial Agents; D010080:Oxazoles; C098012:U 100480