Lung deposition of budesonide from turbuhaler in asthmatic children.
The aim of our study was to evaluate the effect of age on lung deposition of radiolabelled budesonide, delivered as a dry powder via Turbuhaler to asthmatic children. A group of 23 asthmatic children, aged 6 to 16 years, with relatively stable asthma inhaled 99mTc-labelled budesonide from a dry powder inhaler (Turbuhaler). Body and lung deposition was assessed using a gamma camera. The mean (range) median peak inspiratory flow during inhalation was 65 1 x min(-1) (45 to 76 1 x min(-1)). Mean (range) total lung deposition of 99mTc-labelled budesonide, expressed as a percentage of the metered dose, was 29.1% (15.6-47.2%) and was positively and significantly correlated with age, height and peak inspiratory flow.


CONCLUSIONS
Total lung deposition of radiolabelled budesonide from a dry powder inhaler (Turbuhaler), is age dependent in children with moderate asthma. However, lung deposition is still satisfactory, even in younger children with lower peak inspiratory flows.
Wildhaber
J H
JH
Department of Respiratory Medicine, Princess Margaret Hospital for Children, Subiaco, WA, Australia. hannesw@cyllene.uwa.edu.au
Devadason
S G
SG
Wilson
J M
JM
Roller
C
C
Lagana
T
T
Borgström
L
L
LeSouëf
P N
PN
D000293:Adolescent; D000367:Age Factors; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D019819:Budesonide / Q000493:pharmacokinetics*; D002648:Child; D016503:Drug Delivery Systems; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007320:Inspiratory Capacity; D008168:Lung / Q000378:metabolism*; D008297:Male; D009330:Nebulizers and Vaporizers; D014018:Tissue Distribution
D019819:Budesonide