Synthesis and 5 alpha-reductase inhibitory activities of benzofuran derivatives with a carbamoyl group.
A series of 2-phenylbenzofuran derivatives with a diphenylmethylcarbamoyl group at the 5 or 6 position of the benzofuran ring were synthesized and evaluated for rat and human testosterone 5 alpha-reductase inhibitory activities in vitro. They had inhibitory activities against both enzymes and the 6-carbamoyl derivatives tended to be more potent than the 5-carbamoyl compounds.
Ishibashi
K
K
Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
Nakajima
K
K
Sugioka
Y
Y
Sugiyama
M
M
Hamada
T
T
Horikoshi
H
H
Nishi
T
T
D058891:5-alpha Reductase Inhibitors; D000818:Animals; D001572:Benzofurans / Q000138:chemical synthesis* / Q000494:pharmacology; D002219:Carbamates; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D008956:Models, Chemical; D008958:Models, Molecular; D051381:Rats
D058891:5-alpha Reductase Inhibitors; D001572:Benzofurans; D002219:Carbamates; D004791:Enzyme Inhibitors