Bis(5-hydroxy-2-hydroxymethyl-pyran-4-one-6-yl)methane: a novel ligand for the intracellular mobilisation of ferritin-bound iron.
The efficacy of a novel tetradentate iron(III) ligand for the in vitro mobilisation of ferritin-bound iron is measured in direct comparison to the clinically approved agents, 1,2-dimethyl-3-hydroxypyridin-4-one and desferrioxamine.
Fox
R C
RC
Department of Chemistry, University College London, U.K.
Taylor
P D
PD
D000473:Alkanes / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D002478:Cells, Cultured; D005293:Ferritins / Q000378:metabolism*; D007501:Iron / Q000378:metabolism*; D007502:Iron Chelating Agents / Q000737:chemistry / Q000378:metabolism*; D008024:Ligands; D008099:Liver / Q000166:cytology / Q000378:metabolism; D008297:Male; D011714:Pyrans / Q000737:chemistry / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D000473:Alkanes; D007502:Iron Chelating Agents; D008024:Ligands; D011714:Pyrans; C116444:bis(5-hydroxy-2-hydroxymethyl-pyran-4-one-6-yl)methane; D005293:Ferritins; D007501:Iron