[Antioxidants of blood enzymes in kidney function disorders in man].
The activities of lipid peroxidation processes and enzymes of antioxidant system in the blood of patient with renal failure have been studied. The results demonstrated stimulation of lipid peroxidation processes in blood serum, cellular membranes of erythrocytes and in urine. The study of the antioxidant system discovered the inhibition of various enzymes: superoxide dismutase and peroxidase, inhibiting production of active oxygen forms; transferring and ceruloplasmin as regulators of Fe2+/Fe3+ ratio, glutathione reductase and glutathione peroxidase influencing the ratio of oxidated and reduced glutathione forms and the level of SH-groups. So, determination of lipid peroxidation processes and antioxidant enzymes in blood is the sensitive inform test in diagnostics of chronic renal failure.
Nikulina
H H
HH
Institute of Urology and Nephrology, Academy of Medical Sciences of Ukraine, Kyiv.
Baran
Ie Ia
IeIa
Korol'
L V
LV
D000975:Antioxidants / Q000378:metabolism*; D002570:Ceruloplasmin / Q000378:metabolism*; D004910:Erythrocyte Membrane / Q000201:enzymology; D005979:Glutathione Peroxidase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D006801:Humans; D007676:Kidney Failure, Chronic / Q000201:enzymology*; D015227:Lipid Peroxidation / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D013482:Superoxide Dismutase / Q000097:blood; D014168:Transferrin / Q000378:metabolism*
D000975:Antioxidants; D017382:Reactive Oxygen Species; D014168:Transferrin; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D002570:Ceruloplasmin; D005980:Glutathione Reductase
Antyoksydantni fermenty krovi pry porushenni funktsiï nyrok u liudyny.