title: Effects of exercise and EDTA administration on blood ionized calcium and parathyroid hormone in horses.
abstract: OBJECTIVE
  To determine effects of exercise on blood ionized calcium (Ca2+) and plasma parathyroid hormone (PTH) concentrations in horses and to compare the effects of exercise-induced and EDTA-induced hypocalcemia on PTH secretion.
  
  
  METHODS
  17 horses entered in a show jumping competition and 5 horses given EDTA.
  
  
  METHODS
  Blood Ca2+ and plasma PTH concentrations were measured before and after exercise in the 17 horses entered in the jumping competition. In the other 5 horses, concentrations were measured during infusion of EDTA IV.
  
  
  RESULTS
  Exercise resulted in a significant decrease in blood Ca2+ concentration and a significant increase in plasma PTH concentration, and blood Ca2+ concentration was correlated with plasma PTH concentration. Administration of EDTA resulted in hypocalcemia and an increase in PTH concentration. For the same decrease in Ca2+ concentration, magnitude of the exercise-induced increase in PTH concentration was similar to magnitude of the EDTA-induced increase.
  
  
  CONCLUSIONS
  Results suggest that the increase in plasma PTH concentration in horses after exercise is secondary to hypocalcemia and that the increase in PTH concentration seems to be commensurate with the decrease in Ca2+ concentration.
authors.affiliation: Departamento de Medicina y Cirugía Animal, Universidad de Córdoba, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Aguilera-Tejero
authors.forename: B
authors.initials: B
authors.lastname: Garfia
authors.forename: J C
authors.initials: JC
authors.lastname: Estepa
authors.forename: I
authors.initials: I
authors.lastname: López
authors.forename: R
authors.initials: R
authors.lastname: Mayer-Valor
authors.forename: M
authors.initials: M
authors.lastname: Rodríguez
mesh_terms: D000818:Animals; D002118:Calcium / Q000097:blood*; D004492:Edetic Acid / Q000494:pharmacology*; D006736:Horses / Q000502:physiology*; D010281:Parathyroid Hormone / Q000097:blood* / Q000378:metabolism; D010805:Physical Conditioning, Animal / Q000502:physiology*; D005082:Physical Exertion / Q000502:physiology*; D013997:Time Factors
chemical_list: D010281:Parathyroid Hormone; D004492:Edetic Acid; D002118:Calcium