title: Physiological and pathophysiological regulation of cytochrome P450.
abstract: This article is a report on a symposium sponsored by the American Society for Pharmacology and Experimental Therapeutics and held at the April 1998 Experimental Biology '98 meeting in San Francisco. The presentations focused on the mechanisms of regulation of cytochrome P450 gene expression by developmental factors and by hormones and cytokines, as well as on the interplay between physiological and chemical regulation. Approaches and systems used to address these questions included conditional gene knockouts in mice, primary hepatocyte cultures, immunofluorescence imaging of cells, and cell lines stably expressing reporter gene constructs.
authors.affiliation: Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA. etmorga@emory.edu
authors.forename: E T
authors.initials: ET
authors.lastname: Morgan
authors.forename: M B
authors.initials: MB
authors.lastname: Sewer
authors.forename: H
authors.initials: H
authors.lastname: Iber
authors.forename: F J
authors.initials: FJ
authors.lastname: Gonzalez
authors.forename: Y H
authors.initials: YH
authors.lastname: Lee
authors.forename: R H
authors.initials: RH
authors.lastname: Tukey
authors.forename: S
authors.initials: S
authors.lastname: Okino
authors.forename: T
authors.initials: T
authors.lastname: Vu
authors.forename: Y H
authors.initials: YH
authors.lastname: Chen
authors.forename: J S
authors.initials: JS
authors.lastname: Sidhu
authors.forename: C J
authors.initials: CJ
authors.lastname: Omiecinski
mesh_terms: D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D004790:Enzyme Induction / Q000187:drug effects; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology*; D006801:Humans; D051379:Mice
chemical_list: D003577:Cytochrome P-450 Enzyme System