title: [Regional lymphotropic chemotherapy in breast cancer--a new approach in the therapeutic procedure for the parasternal lymph nodes].
abstract: A method of regional lymphotropic chemotherapy in breast cancer is presented, aimed at attaining higher cytostatic concentration in the region of parasternal lymph nodes. In twenty-three women with centrally and medially situated tumors preoperatively 1 mg Mitoxantrone is applied around the 4 tumor poles each. In ten cases (IIb and IIIa stage) given 3 courses of nonadjuvant chemotherapy, part of the Cyclophosphamide dose is administered as regionally lymphotropic subxiphoid bilaterally. The clinical response, distribution of the Mitoxantrone blue stained regional lymph nodes and the morphological changes in the latter are analyzed. The early clinical observations indicate that the method proposed is technically easily executed, with a good local tolerance, and has a definite place in the complex treatment of breast cancer.
authors.forename: G
authors.initials: G
authors.lastname: Baĭchev
authors.forename: T
authors.initials: T
authors.lastname: Deliĭski
authors.forename: S
authors.initials: S
authors.lastname: Polovska
authors.forename: M
authors.initials: M
authors.lastname: Boĭkov
mesh_terms: D000328:Adult; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D003520:Cyclophosphamide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007272:Injections, Intralymphatic; D008207:Lymphatic Metastasis; D015411:Mastectomy, Modified Radical; D008875:Middle Aged; D008942:Mitoxantrone / Q000008:administration & dosage; D009367:Neoplasm Staging; D011300:Preoperative Care; D011446:Prospective Studies; D013249:Sternum
chemical_list: D018906:Antineoplastic Agents, Alkylating; D003520:Cyclophosphamide; D008942:Mitoxantrone
vernacular_title: Regionalna limfotropna khimioterapiia pri RMZh--nov podkhod v lechebnata taktika za parasternalnite limfni vŭzli.