title: Topoisomerase I inhibitors from the Streptomyces sp. strain KM86-9B isolated from a marine sponge.
abstract: The crude extract of Streptomyces sp. strain KM86-9B, isolated from a marine sponge, displayed significant inhibition on topoisomerase I activity. Investigation of the causative components by bioactivity-directed fractionation resulted in the isolation of a series of iso- and anteiso-fatty acids.
authors.affiliation: Microbiology Lab., Korea Ocean Research & Development Institute, Ansan, Korea.
authors.forename: H K
authors.initials: HK
authors.lastname: Lee
authors.forename: D S
authors.initials: DS
authors.lastname: Lee
authors.forename: J
authors.initials: J
authors.lastname: Lim
authors.forename: J S
authors.initials: JS
authors.lastname: Kim
authors.forename: K S
authors.initials: KS
authors.lastname: Im
authors.forename: J H
authors.initials: JH
authors.lastname: Jung
mesh_terms: D000818:Animals; D005591:Chemical Fractionation; D005227:Fatty Acids / Q000302:isolation & purification / Q000494:pharmacology*; D011161:Porifera / Q000382:microbiology*; D013302:Streptomyces / Q000737:chemistry*; D059004:Topoisomerase I Inhibitors
chemical_list: D005227:Fatty Acids; D059004:Topoisomerase I Inhibitors