title: Neuronal activity in the cholinoceptive basal forebrain of freely moving narcoleptic dobermans.
abstract: Cholinergic stimulation in the basal forebrain (BF) triggers cataplexy in canine narcolepsy. Extracellular single unit recordings in the BF were carried out in freely moving narcoleptic dogs to study the neuronal mechanisms mediating cataplexy induction in the BF. Among the 64 recorded neurons, 12 were wake-active, three were slow wave sleep (SWS)-active, 17 were wake-/REM-active, 11 were REM sleep-active, three were cataplexy-active, and the other 18 were state-independent. Systemic administration of physostigmine, a cholinesterase inhibitor, induces status cataplecticus, decreases SWS and increases acetylcholine levels in the BF. Firing of most of the state-dependent neurons in the BF was significantly modified by physostigmine. Some of these neurons may thus mediate sleep stage changes or the effect on cataplexy observed after cholinergic stimulation in the BF.
authors.affiliation: Center for Narcolepsy, Department of Psychiatry and Behavioral Science, Stanford University School of Medicine, Palo Alto, CA 94304, USA.
authors.forename: S
authors.initials: S
authors.lastname: Nishino
authors.forename: K
authors.initials: K
authors.lastname: Honda
authors.forename: J
authors.initials: J
authors.lastname: Riehl
authors.forename: M
authors.initials: M
authors.lastname: Okura
authors.forename: E
authors.initials: E
authors.lastname: Mignot
mesh_terms: D000109:Acetylcholine / Q000502:physiology*; D000818:Animals; D002799:Cholinergic Fibers / Q000187:drug effects / Q000502:physiology; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D004195:Disease Models, Animal; D004285:Dogs; D004558:Electric Stimulation; D004569:Electroencephalography; D004576:Electromyography; D004585:Electrooculography; D005260:Female; D008124:Locomotion; D008297:Male; D009290:Narcolepsy / Q000503:physiopathology*; D010830:Physostigmine / Q000494:pharmacology; D016548:Prosencephalon / Q000166:cytology / Q000502:physiology*; D012895:Sleep, REM / Q000187:drug effects / Q000502:physiology; D014851:Wakefulness / Q000187:drug effects / Q000502:physiology
chemical_list: D002800:Cholinesterase Inhibitors; D010830:Physostigmine; D000109:Acetylcholine