title: DNA cleaving activities of 9-membered masked enediyne analogues possessing DNA intercalator and sugar moieties.
abstract: The DNA cleaving properties of various enediyne analogues possessing sugar moieties and DNA-intercalators were investigated. The DNA cleaving experiments show that these hybrids analogues induced sequence-selective DNA cleavage and the simple sugars in the enediyne serve as a DNA recognition element for DNA cleavage.
authors.affiliation: Department of Chemical Engineering, Tokyo Institute of Technology, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: A
authors.initials: A
authors.lastname: Matsuda
authors.forename: T
authors.initials: T
authors.lastname: Doi
authors.forename: H
authors.initials: H
authors.lastname: Yamada
authors.forename: T
authors.initials: T
authors.lastname: Matsumoto
authors.forename: D
authors.initials: D
authors.lastname: Sasaki
authors.forename: Y
authors.initials: Y
authors.lastname: Sugiura
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D001483:Base Sequence; D002241:Carbohydrates; D004247:DNA / Q000187:drug effects* / Q000378:metabolism; D007364:Intercalating Agents / Q000494:pharmacology*; D008969:Molecular Sequence Data; D013329:Structure-Activity Relationship
chemical_list: D000903:Antibiotics, Antineoplastic; D002241:Carbohydrates; D007364:Intercalating Agents; D004247:DNA