Influence of sino-aortic barodenervation on the cardiovascular effects of imidazoline-like drugs.
Earlier findings have shown that hypotensive effects of centrally acting drugs, such as clonidine, are enhanced in animals after denervation of arterial baroreceptors. The purpose of this study was to investigate the dynamic of changes in arterial pressure, heart rate and hypotensive effects of clonidine, rilmenidine and moxonidine in Wistar rats after sino-aortic denervation (SAD) using radio-telemetry. SAD was followed by significant elevation of arterial pressure lability (the standard deviation of the mean arterial pressure), while the baseline mean arterial pressure (MAP) and heart rate in barodenervated rats (12 days after SAD) was similar to intact rats. The hypotension produced by clonidine, rilmenidine and moxonidine was much greater in SAD rats than in intact rats. The study suggests that baroreflex mechanisms are not only important for maintaining levels of blood pressure in the very short term, but also for buffering the effects of centrally acting antihypertensive drugs.
Medvedev
O S
OS
Faculty of Basic Medicine, Department of Pharmacology, Moscow State University, Russian Federation.
Kunduzova
O R
OR
Murashev
A N
AN
Medvedeva
N A
NA
D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D002940:Circadian Rhythm; D003000:Clonidine / Q000008:administration & dosage / Q000494:pharmacology; D003714:Denervation; D006339:Heart Rate / Q000187:drug effects*; D007093:Imidazoles / Q000008:administration & dosage / Q000494:pharmacology*; D007275:Injections, Intravenous; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D010080:Oxazoles / Q000008:administration & dosage / Q000494:pharmacology; D011311:Pressoreceptors / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D000077769:Rilmenidine; D012850:Sinus of Valsalva / Q000294:innervation / Q000502:physiology*; D013686:Telemetry
D000959:Antihypertensive Agents; D007093:Imidazoles; D010080:Oxazoles; C043482:moxonidine; D003000:Clonidine; D000077769:Rilmenidine