title: Anti-malarial activities of acylated bruceolide derivatives.
abstract: Several O-acylated derivatives of bruceolide (2) were synthesized and their anti-malarial activities together with selective toxicities were examined. It was found that 3,15-di-O-acetyl-(3c), 3,15-di-O-propionyl-(3d) and 15-O-propionylbruceolide (3b), as well as bruceine B (3a), exhibited potent anti-malarial activities with high selective toxicities.
authors.affiliation: Faculty of Pharmaceutical Sciences, Osaka University, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Murakami
authors.forename: T
authors.initials: T
authors.lastname: Umezome
authors.forename: T
authors.initials: T
authors.lastname: Mahmud
authors.forename: M
authors.initials: M
authors.lastname: Sugimoto
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Wataya
authors.forename: H S
authors.initials: HS
authors.lastname: Kim
mesh_terms: D000215:Acylation; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D005900:Glaucarubin / Q000494:pharmacology*; D051379:Mice; D010963:Plasmodium falciparum / Q000187:drug effects; D014407:Tumor Cells, Cultured
chemical_list: D000962:Antimalarials; D005900:Glaucarubin