Contrast medium-removing effect of hemofiltration and hemodiafiltration.
The contrast medium-removing effect of hemofiltration (HF) and hemodiafiltration (HDF) was experimentally investigated using a bovine blood tank model. HF and HDF were performed at a blood flow rate of 100 ml/min with a polysulfone hemofilter (PS filter-CF; membrane area: 0.7 m2). Two hundred milliliters of iomeprol (300 mgI/ml) was administered by a single injection into 4 liters of bovine blood. The blood half-lives of iomeprol were 1.0 hr for the high flow rate HDF group [replacement fluid flow rate (QF): 10 ml/min and dialysate flow rate (QD): 40 ml/min], 1.8 hr for the HDF group (QF: 10 ml/min and QD: 10 ml/min), and 3.8 hr for the HF group (QF: 10 ml/min). The mean clearance rates were 39.7 ml/min for the high flow rate HDF group, 21.4 ml/min for the HDF group, and 12.0 ml/min for the HF group. Iomeprol was mostly excreted in the waste fluid. It is concluded that HDF can remove contrast media more effectively than HF.
Okahisa
T
T
Second Department of Internal Medicine, University of Tokushima School of Medicine, Japan.
Sogabe
M
M
Hayashi
S
S
Shibata
H
H
Ito
S
S
D000818:Animals; D002417:Cattle; D003287:Contrast Media / Q000493:pharmacokinetics*; D006207:Half-Life; D017583:Hemodiafiltration; D006440:Hemofiltration; D007479:Iopamidol / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
D003287:Contrast Media; C057937:iomeprol; D007479:Iopamidol