[Effect of alpha-tocopherol and its derivatives on the viability of cultured malignant cells].
The effect of alpha-tocopherol and its derivatives on viability and growth of attached cells culture: human epithelioid carcinoma of cervix HeLa-S3K and human cervical carcinoma cell line C-4-1 according to protein content and level of alkaline phosphatase, as well to unattached cells: human acute leukemia cell cultures CEM-C-1 and CEM-C-7 according to the amount of viable cells in suspension has been studied. It has been shown that alpha-tocopherol acetate and tocopherol maintain the viability of cells, while the derivatives of tocopherol with shorted side chain considerably inhibit growth of researched cultures, alpha-tocopherol with lacking side chain being most active among them.
Donchenko
G V
GV
A.V. Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv.
Kholodova
Iu D
IuD
Kuz'menko
I V
IV
Klimenko
E P
EP
D000469:Alkaline Phosphatase / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects*; D006801:Humans; D009363:Neoplasm Proteins / Q000378:metabolism; D014407:Tumor Cells, Cultured; D014810:Vitamin E / Q000494:pharmacology*
D009363:Neoplasm Proteins; D014810:Vitamin E; D000469:Alkaline Phosphatase
Vliianie alpha-tokoferola i ego proizvodnykh na zhiznesposobnost' kul'tury zlokachestvennykh kletok.