title: Comparison of the complete protein sets of worm and yeast: orthology and divergence.
abstract: Comparative analysis of predicted protein sequences encoded by the genomes of Caenorhabditis elegans and Saccharomyces cerevisiae suggests that most of the core biological functions are carried out by orthologous proteins (proteins of different species that can be traced back to a common ancestor) that occur in comparable numbers. The specialized processes of signal transduction and regulatory control that are unique to the multicellular worm appear to use novel proteins, many of which re-use conserved domains. Major expansion of the number of some of these domains seen in the worm may have contributed to the advent of multicellularity. The proteins conserved in yeast and worm are likely to have orthologs throughout eukaryotes; in contrast, the proteins unique to the worm may well define metazoans.
authors.affiliation: Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305-5120, USA.
authors.forename: S A
authors.initials: SA
authors.lastname: Chervitz
authors.forename: L
authors.initials: L
authors.lastname: Aravind
authors.forename: G
authors.initials: G
authors.lastname: Sherlock
authors.forename: C A
authors.initials: CA
authors.lastname: Ball
authors.forename: E V
authors.initials: EV
authors.lastname: Koonin
authors.forename: S S
authors.initials: SS
authors.lastname: Dwight
authors.forename: M A
authors.initials: MA
authors.lastname: Harris
authors.forename: K
authors.initials: K
authors.lastname: Dolinski
authors.forename: S
authors.initials: S
authors.lastname: Mohr
authors.forename: T
authors.initials: T
authors.lastname: Smith
authors.forename: S
authors.initials: S
authors.lastname: Weng
authors.forename: J M
authors.initials: JM
authors.lastname: Cherry
authors.forename: D
authors.initials: D
authors.lastname: Botstein
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000737:chemistry* / Q000235:genetics / Q000502:physiology; D019143:Evolution, Molecular; D005656:Fungal Proteins / Q000737:chemistry* / Q000235:genetics / Q000502:physiology; D005786:Gene Expression Regulation; D005800:Genes, Fungal; D017238:Genes, Helminth; D015801:Helminth Proteins / Q000737:chemistry* / Q000235:genetics / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000737:chemistry* / Q000235:genetics / Q000502:physiology; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction
chemical_list: D005656:Fungal Proteins; D015801:Helminth Proteins