title: New synthetic inhibitors of microtubule depolymerization.
abstract: A new class of borneol esters that might be considered as biological analogs of paclitaxel regarding their action on microtubules has been found. By structure-activity optimizations, compounds stabilizing microtubules much better than paclitaxel while showing a remarkably reduced cytotoxic activity were obtained. This dissoziation will open completely new therapeutic areas.
authors.affiliation: Research Laboratories of Schering AG, Berlin, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Klar
authors.forename: H
authors.initials: H
authors.lastname: Graf
authors.forename: O
authors.initials: O
authors.lastname: Schenk
authors.forename: B
authors.initials: B
authors.lastname: Röhr
authors.forename: H
authors.initials: H
authors.lastname: Schulz
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D001704:Biopolymers; D001892:Camphanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008870:Microtubules / Q000187:drug effects / Q000378:metabolism*; D008958:Models, Molecular; D017239:Paclitaxel / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D001704:Biopolymers; D001892:Camphanes; C022871:isoborneol; D017239:Paclitaxel