title: Management of recipients of hepatic allografts harvested from donors with malignancy diagnosed shortly after transplantation.
abstract: Transmission of undiagnosed malignancy with the graft is a dramatic complication of liver transplantation. Alternatives in the management of the recipients of livers, harvested from donors with malignancy diagnosed shortly after transplantation, are either early re-transplantation or close follow-up without re-operation. We reported 4 cases of liver recipients whose allografts were harvested from donors who were diagnosed with malignancy shortly after the liver transplantation. One recipient underwent re-transplantation, and the three other allografts were not removed. No recipient developed recurrence in the follow-up. While graft removal may be the only way to avoid tumor recurrence in recipients of liver graft harvested from donor with malignancy, close follow-up without re-operation may also be considered. The risk of tumor transferral may depend on the histopathological aggressiveness and metastatic potential of the donor tumor, and may be low for low-grade, local tumors. This risk should be evaluated by analyzing large series, using databases of Eurotransplant or United Network for Organ Sharing.
authors.affiliation: Department of Surgery and Transplantation, CHU Sart Tilman, Liège, Belgium. Oli.Detry@chu.ulg.ac.be
authors.forename: O
authors.initials: O
authors.lastname: Detry
authors.forename: P
authors.initials: P
authors.lastname: Honoré
authors.forename: N
authors.initials: N
authors.lastname: Jacquet
authors.forename: M
authors.initials: M
authors.lastname: Meurisse
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control; D012086:Reoperation; D014019:Tissue Donors