[A new test for monitoring heparin therapy].
A simple and easy assay for plasma heparin measurement (international units/ml) is described. The method is based upon the heparin neutralization and titration by polybrene. Heparin biological activity is measured first by activated partial thromboplastin time prolongment and then by means of polybrene titration: plasma heparin concentration was evaluated in international units/ml (IU/ml). The design and properties of this method are reported. Application in clinical practice of monitoring heparinization during hemodialysis is evaluated.
Camici
M
M
Insegnamento di Semeiotica Medica, Università degli Studi, Pisa.
Evangelisti
L
L
Giordani
R
R
D000925:Anticoagulants / Q000097:blood*; D001774:Blood Chemical Analysis / Q000379:methods; D006493:Heparin / Q000097:blood*; D006801:Humans; D008991:Monitoring, Physiologic; D010314:Partial Thromboplastin Time
D000925:Anticoagulants; D006493:Heparin
Un nuovo test per il monitoraggio della terapia eparinica.