title: Ascorbic acid-based inhibitors of alpha-amylases.
abstract: A series of ascorbic acid and isoascorbic acid derivatives has been evaluated as inhibitors of malt, bacterial, fungal, pancreatic and salivary alpha-amylases using a simple and quick assay procedure. The results demonstrate that the enediol moiety of ascorbic acid is essential for alpha-amylase inhibition. Acylation of the primary and secondary alcohols, and the absolute configuration of the secondary alcohol, do not affect the potency of inhibition.
authors.affiliation: Department of Chemistry, University of Canterbury, Christchurch, New Zealand.
authors.forename: A D
authors.initials: AD
authors.lastname: Abell
authors.forename: M J
authors.initials: MJ
authors.lastname: Ratcliffe
authors.forename: J
authors.initials: J
authors.lastname: Gerrard
mesh_terms: D058833:Antithrombin Proteins; D000991:Antithrombins / Q000737:chemistry* / Q000494:pharmacology; D001205:Ascorbic Acid / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D007700:Kinetics; D000516:alpha-Amylases / Q000037:antagonists & inhibitors*
chemical_list: D058833:Antithrombin Proteins; D000991:Antithrombins; D004791:Enzyme Inhibitors; C116660:L 636619; D000516:alpha-Amylases; D001205:Ascorbic Acid