title: Estimating the rate of evolution of the rate of molecular evolution.
abstract: A simple model for the evolution of the rate of molecular evolution is presented. With a Bayesian approach, this model can serve as the basis for estimating dates of important evolutionary events even in the absence of the assumption of constant rates among evolutionary lineages. The method can be used in conjunction with any of the widely used models for nucleotide substitution or amino acid replacement. It is illustrated by analyzing a data set of rbcL protein sequences.
authors.affiliation: Statistics Department, North Carolina State University, Raleigh 27695-8203, USA. thorne@statgen.ncsu.edu
authors.forename: J L
authors.initials: JL
authors.lastname: Thorne
authors.forename: H
authors.initials: H
authors.lastname: Kishino
authors.forename: I S
authors.initials: IS
authors.lastname: Painter
mesh_terms: D000465:Algorithms; D005075:Biological Evolution; D019143:Evolution, Molecular; D008957:Models, Genetic; D015233:Models, Statistical; D010802:Phylogeny; D010940:Plant Proteins / Q000235:genetics; D010944:Plants / Q000145:classification* / Q000235:genetics*; D012273:Ribulose-Bisphosphate Carboxylase; D013995:Time
chemical_list: D010940:Plant Proteins; C101625:RbcL protein, plastid; D012273:Ribulose-Bisphosphate Carboxylase