Synthesis and immobilization of ceramide analogs on silica particles.
Ceramides are the major lipid components of the stratum corneum, the major permeability barrier of the skin. Here we report a chemical synthesis of ceramide analogs covalently bonded on the silica particles, that can be used to predict the skin permeability of chemicals via HPLC methods.
Yin
J
J
Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA.
Liu
H
H
Pidgeon
C
C
D002518:Ceramides / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid; D010539:Permeability; D012822:Silicon Dioxide / Q000737:chemistry*; D012867:Skin / Q000378:metabolism
D002518:Ceramides; D012822:Silicon Dioxide