Inhibitors of the bacterial cell wall biosynthesis enzyme MurD.
A series of transition-state analog inhibitors of the D-glutamic acid-adding enzyme (MurD) of bacterial peptidoglycan biosynthesis has been synthesized and evaluated for inhibition of the E. coli enzyme.
Gegnas
L D
LD
Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA.
Waddell
S T
ST
Chabin
R M
RM
Reddy
S
S
Wong
K K
KK
D002473:Cell Wall / Q000201:enzymology*; D004926:Escherichia coli / Q000201:enzymology*; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000737:chemistry; D010453:Peptide Synthases / Q000037:antagonists & inhibitors* / Q000737:chemistry
D009943:Organophosphorus Compounds; D010453:Peptide Synthases; C053379:UDP-N-acetylmuramoylalanine-D-glutamate ligase