[Radiation-induced cancers].
The induction of malignant diseases is one of the most concerning late effects of ionising radiation. A large amount of information has been collected form atomic bomb survivors, patients after therapeutic irradiation, occupational follow-up and accidentally exposed populations. Major uncertainties persist in the (very) low dose range i.e., population and workers radioprotection. A review of the biological mechanisms leading to cancer strongly suggests that the vast majority of radiation-induced malignancies arise as a consequence of recessive mutations of tumour-suppressor genes. These mutations can be unveiled by ageing, this process being possibly furthered by constitutional or acquired genomic instability. The individual risk is likely to be very low, probably because of the usual dose level. However, the magnitude of medical exposure and the reliance of our societies on nuclear industry are so high that irreproachable decision-making processes and standards for practice are inescapable.
Dutrillaux
B
B
UMR 147, CNRS-LRC CEA n(o) 3-Institut Curie, Paris, France.
D000375:Aging / Q000235:genetics; D004781:Environmental Exposure / Q000009:adverse effects; D016147:Genes, Tumor Suppressor / Q000235:genetics; D006801:Humans; D009154:Mutation / Q000235:genetics; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000517:prevention & control; D009689:Nuclear Warfare; D011835:Radiation Protection; D011878:Radiotherapy / Q000009:adverse effects; D012307:Risk Factors
Les cancers radio-induits.