[T lymphocytes in allergic inflammation].
T lymphocytes are the crucial cells in immunopathogenesis of allergic diseases since they regulate the occurrence of allergic sensitisation, synthesis of immunoglobulin E and allergic inflammation. The importance of lymphocyte T is reflected on the fact that after activation by a specific antigen they are able to produce different cytokines responsible for activation and aggregation of specific inflammatory cells in target tissues, promoting the occurrence and maintenance of allergic inflammation. Discovery of functional dichotomy of activated lymphocytes T CD4+ capable of suppressing synthesis of immunoglobulin E (Th1) or stimulate immunoglobulin E and allergic inflammation (Th2) is an important element in elucidation of pathogenesis of allergic inflammation and inadequate synthesis of immunoglobulin E. The immunoglobulin synthesis is regulated by a complex combination of factors and signals where lymphocytes CD4+ play the central regulatory role.
Tomić-Spirić
V
V
Department of Allergology and Immunology, Clinical Centre of Serbia, Belgrade.
Bogić
M
M
Janković
S
S
Rasković
S
S
Djurić
V
V
Sojić-Rajcić
J
J
D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007249:Inflammation; D013601:T-Lymphocytes / Q000276:immunology*
Limfociti T u alergijskoj inflamaciji.