New antifungals selected by molecular topology.
Molecular topology has been applied to find the new lead antimycotic compounds. Among the selected compounds stands out 3,3'-(4,4'-Biphenylene)bis(2,5-diphenyl-2H-tetrazolium chloride), Benztropine mesylate and Dicyclopentamethylenethiuram disulphide, with minimum inhibitory concentrations between 1.6 and 2 micrograms/mL.
Pastor
L
L
Unidad de Investigación de Diseño de Fármacos, Facultad de Farmacia, Universitat de Valencia, Spain.
García-Domenech
R
R
Gálvez
J
J
Wolski
S
S
García
M D
MD
D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D016002:Discriminant Analysis; D015195:Drug Design; D008826:Microbial Sensitivity Tests; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D013329:Structure-Activity Relationship
D000935:Antifungal Agents