Renal involvement in Russell's viper bite patients without disseminated intravascular coagulation.
We measured urinary beta-N-acetylglucosaminidase (NAG: EC 3.2.1.30), blood urea, serum creatinine, albuminuria index and creatinine clearance in 16 patients bitten by Russell's viper (Daboia russelii siamensis) without disseminated intravascular coagulation (DIC) at the time of admission and then once daily for 5 d. Urinary NAG activity and the albuminuria index showed considerable variation whereas the other standard indicators of renal function revealed no abnormality. It is concluded that structural damage to the kidney occurred in these victims in the absence of DIC, indicating a direct toxic effect of Russell's viper venom on the kidney.
Win-Aung
Khin-Pa-Pa-Kyaw
Baby-Hla
Saw-Sandar-Aye
Saw-Phone-Naing
Aye-Kyaw
Tin-Nu-Swe
D000118:Acetylglucosaminidase / Q000652:urine; D058186:Acute Kidney Injury / Q000209:etiology*; D000293:Adolescent; D000328:Adult; D000419:Albuminuria; D000818:Animals; D003404:Creatinine / Q000097:blood / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D002052:Myanmar; D017840:Daboia; D012909:Snake Bites / Q000150:complications*; D012910:Snake Venoms / Q000506:poisoning*; D014511:Uremia / Q000175:diagnosis*
D012910:Snake Venoms; D003404:Creatinine; D000118:Acetylglucosaminidase