Novel antiproliferative falcarindiol furanocoumarin ethers from the root of Angelica japonica.
Four novel antiproliferative furanocoumarin ethers of falcarindiol, named japoangelols A (8.5), B (7.2), C (7.4), and D (8.4), were isolated from the root of Angelica japonica together with panaxynol (0.3), falcarindiol (3.2), (9Z)-1,9-heptadecadiene-4,6-diyne-3,8,11-triol (2.2), and 8-acetoxyfalcarinol (3.2). Structures were established from the spectroscopic evidence, and the inhibitory activities (ED50, microgram/ml, shown in the parentheses) were evaluated using the MTT assay.
Furumi
K
K
Faculty of Pharmaceutical Sciences, Fukuoka University, Japan.
Fujioka
T
T
Fujii
H
H
Okabe
H
H
Nakano
Y
Y
Matsunaga
H
H
Katano
M
M
Mori
M
M
Mihashi
K
K
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D053280:Diynes; D004354:Drug Screening Assays, Antitumor; D004987:Ethers; D005233:Fatty Alcohols / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D018517:Plant Roots / Q000737:chemistry; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D053280:Diynes; D004987:Ethers; D005233:Fatty Alcohols; C034379:falcarindiol