title: Rhenium-188 microspheres: a new radiation synovectomy agent.
abstract: Radiation synovectomy is efficacious in controlling the symptoms of rheumatoid arthritis. However, the procedure is not widely used because of concerns about leakage of radiopharmaceuticals from the treated joints. Leakage can be minimized by selecting particles of an appropriate size. In this study, we labelled microspheres with 188Re and analysed its biodistribution after intra-articular injection in rabbits with antigen-induced arthritis. Gamma camera imaging was performed to quantify the mean retention of 188Re in the knees. The mean retention of 188Re was 98.7, 94.6 and 93.6% at 1, 24 and 48 h, respectively. The biodistribution data revealed very low radioactivity in all organs at different times, which suggests the leakage of radiotracer from the knee was negligible. Our preliminary results indicate that 188Re microspheres are a potentially effective radiopharmaceutical for radiation synovectomy.
authors.affiliation: Department of Nuclear Medicine, Veterans General Hospital, Taichung and National Yang-Ming University, Taipei, Taiwan.
authors.forename: S J
authors.initials: SJ
authors.lastname: Wang
authors.forename: W Y
authors.initials: WY
authors.lastname: Lin
authors.forename: M N
authors.initials: MN
authors.lastname: Chen
authors.forename: B T
authors.initials: BT
authors.lastname: Hsieh
authors.forename: L H
authors.initials: LH
authors.lastname: Shen
authors.forename: Z T
authors.initials: ZT
authors.lastname: Tsai
authors.forename: G
authors.initials: G
authors.lastname: Ting
authors.forename: J T
authors.initials: JT
authors.lastname: Chen
authors.forename: W L
authors.initials: WL
authors.lastname: Ho
authors.forename: S
authors.initials: S
authors.lastname: Mirzadeh
authors.forename: F F
authors.initials: FF
authors.lastname: Knapp
mesh_terms: D000818:Animals; D001169:Arthritis, Experimental / Q000532:radiotherapy*; D004355:Drug Stability; D007270:Injections, Intra-Articular; D008297:Male; D008863:Microspheres; D011817:Rabbits; D011829:Radiation Dosage; D011868:Radioisotopes / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D019275:Radiopharmaceuticals / Q000009:adverse effects / Q000627:therapeutic use* / Q000633:toxicity; D012211:Rhenium / Q000009:adverse effects / Q000627:therapeutic use* / Q000633:toxicity; D013583:Synovial Membrane / Q000528:radiation effects; D014018:Tissue Distribution
chemical_list: D011868:Radioisotopes; D019275:Radiopharmaceuticals; D012211:Rhenium