Effects of in vivo taurine depletion on induced-chemiluminescence production in macrophages isolated from rat lungs.
Alveolar macrophages isolated by pulmonary lavage from partially taurine-depleted rats demonstrated increased (2-2.6 fold) chemiluminescence due to the extracellular reaction between exogenous zymosan and various reactive forms of oxygen compared to macrophages isolated from control animals. Partial taurine depletion was achieved by adding 3% beta-alanine to the drinking water of the rats for 5 weeks prior to harvesting the macrophages. Superoxide dismutase activity was not increased in the lung tissue of the taurine-depleted rats. These data suggest that taurine has antioxidant properties and that taurine depletion is potentially deleterious to alveolar macrophages and pulmonary tissue.
Zhang
X
X
Department of Pharmacology, Texas Tech University Health Sciences Center, Lubbock, USA.
Lombardini
J B
JB
D000818:Animals; D008163:Luminescent Measurements; D008168:Lung / Q000502:physiology*; D016676:Macrophages, Alveolar / Q000502:physiology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase; D013654:Taurine / Q000172:deficiency*; D015054:Zymosan; D015091:beta-Alanine / Q000494:pharmacology
D017382:Reactive Oxygen Species; D015091:beta-Alanine; D013654:Taurine; D015054:Zymosan; D013482:Superoxide Dismutase