[Basophilic blast crisis in chronic myeloid leukemia].
Acute basophilic leukaemia is usually characterized by a very rapid clinical course, hyperhistaminemia, resistance to antineoplastic therapy and early death due to complications related to disease. This entity is a rare condition, accounting for less than two percent of all haematopoietic malignancies. Most of the case reports are basophilic blast crisis in patients with a previous lympho or myeloproliferative disorder. A 62-year-old woman who was diagnosed as Philadelphia positive chronic myelogenous leukaemia after four years of evolution developed a basophilic blast crisis, whose characteristics are reported. Accompanying this transformation there was also a cytogenetic change. Despite chemotherapy the patient died of disease progression.
García Fernández
J R
JR
Unidad de Hematología, Hospital General Básico, Baza, Granada.
montalbán
M A
MA
Martín
M L
ML
Ortiz
M C
MC
Martínez
M A
MA
García Marcilla
A
A
D001752:Blast Crisis / Q000150:complications / Q000235:genetics*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007621:Karyotyping; D015471:Leukemia, Basophilic, Acute / Q000150:complications / Q000235:genetics*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000235:genetics*; D008875:Middle Aged
Crisis blástica basófila de leucemia mieloide crónica.