title: Hip involvement in seropositive rheumatoid arthritis. Survivorship analysis with a 15-year follow-up.
abstract: In a prospective survey of recent arthritis 96 patients had erosive and seropositive rheumatoid arthritis (RA). Severe radiological changes in the hipjoint (Larsen grade 3-5) were observed in 31 (32%) and acetabular protrusion in five (5%) patients 15 years after the onset of arthritis. At the end of follow-up Larsen score 0-100 of peripheral joints (p < 0.015), HAQ (p < 0.001), ESR (p < 0.001), and CRP (p < 0.01) were significantly higher in patients with hip joint destruction than in those without. Secondary amyloidosis was found in eight patients with and in three patients without hip involvement (p = 0.002). In survivorship analysis (the Larsen 0-2 grade hips) an overall predicted rate of survival was 80% after 14 years of rheumatoid arthritis. When analyzed according to HLA-B27 the rate of radiological survival for the patients with a positive test was 62% and 87% for the others (p = 0.02). In conclusion, RA patients with high number of destructive peripheral joints (Larsen score) and high ESR or CRP should be carefully monitored due to the increased risk of hip destruction.
authors.affiliation: Department of Rheumatoid Surgery and Orthopedics, Tampere University Hospital, Finland.
authors.forename: M Y
authors.initials: MY
authors.lastname: Lehtimäki
authors.forename: H
authors.initials: H
authors.lastname: Kautiainen
authors.forename: M M
authors.initials: MM
authors.lastname: Hämäläinen
authors.forename: M U
authors.initials: MU
authors.lastname: Lehto
authors.forename: M
authors.initials: M
authors.lastname: Ikävalko
authors.forename: A B
authors.initials: AB
authors.lastname: Repo
authors.forename: H A
authors.initials: HA
authors.lastname: Kotaniemi
authors.forename: K
authors.initials: K
authors.lastname: Kaarela
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology*; D015331:Cohort Studies; D005500:Follow-Up Studies; D006615:Hip / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D011859:Radiography; D012217:Rheumatoid Factor / Q000032:analysis; D012307:Risk Factors; D012720:Severity of Illness Index; D015996:Survival Rate
chemical_list: D012217:Rheumatoid Factor