[The structural organization of the aortic endothelium in hypercholesterolemia and the effect of L-arginine].
Electron microscopic investigation of the rabbit [correction of rat] thoracic aorta revealed endothelium to be most vulnerable to the damage in experimental hypercholesterolemia. Administration of precursor of nitric oxide L-arginine against the background of hypercholesterolemia resulted in activation of functional activity of the endothelium of aorta. This notion is supported by an increase of the quantity of protein-synthesizing structures (ribosomes, polysomes, canaliculi of endoplasmic network), secretory granules vs rabbits on atherogenic diet. At stimulation of NO-synthase activity of endothelium the dilatory reactions of aortal strips to acetylcholine are improved.
Tkachenko
M M
MM
A. A. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kiev.
Stechenko
L O
LO
Sahach
V F
VF
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000201:enzymology / Q000648:ultrastructure*; D001120:Arginine / Q000627:therapeutic use*; D004036:Diet, Atherogenic; D004353:Drug Evaluation, Preclinical; D004730:Endothelium, Vascular / Q000187:drug effects / Q000201:enzymology / Q000648:ultrastructure*; D006937:Hypercholesterolemia / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology*; D008854:Microscopy, Electron; D009569:Nitric Oxide / Q000096:biosynthesis; D019001:Nitric Oxide Synthase / Q000187:drug effects / Q000378:metabolism; D011817:Rabbits
D009569:Nitric Oxide; D001120:Arginine; D019001:Nitric Oxide Synthase
Strukturna orhanizatsiia endoteliiu aorty za umov hiperkholesterynemiï ta vplyvu L-arhininu.