Conformationally constrained NO synthase inhibitors: rigid analogs of L-N-iminoethylornithine.
The synthesis of eight rigid analogs of L-N-iminoethylornithine (L-NIO) is described. The compounds have been evaluated for their inhibition of inducible nitric oxide synthase. Preliminary structure-activity relationships are discussed.
Eustache
J
J
Laboratoire de Synthèse Organique et Chimie Microbienne associé au CNRS, Université de Haute-Alsace, Ecole Nationale Supérieure de Chimie de Mulhouse, France. j.eustache@univ-mulhouse.fr
Grob
A
A
Lam
C
C
Sellier
O
O
Schulz
G
G
D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D008968:Molecular Conformation; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D052247:Nitric Oxide Synthase Type II; D009952:Ornithine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; C065027:N(G)-iminoethylornithine; D009952:Ornithine; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II