title: Inhibition of bacterial pathogens by lactobacilli.
abstract: Lactobacilli produce many antimicrobial substances including organic acids, hydrogen peroxide and bacteriocins. Antagonistic activity of lactobacilli is an important factor in the protection of the vagina of fertile women against infection by certain pathogens. In the present study, we investigated 17 strains of lactobacilli, including 11 strains of vaginal origin. The aim was to investigate in more detail the antibacterial activity of lactobacilli and to attempt to assess substances responsible for inhibition. The investigated lactobacilli inhibited some strains of Escherichia coli, Serratia marcescens, Shigella boydii, Listeria monocytogenes, Listeria ivanovii, Listeria innocua and Staphylococcus aureus. We have provided evidence that inhibition is due mainly to organic acids and to a lesser extent, to bacteriocins.
authors.affiliation: Microbiological Institute of St. Anne's Faculty Hospital, Brno, Czech Republic.
authors.forename: T
authors.initials: T
authors.lastname: Dembélé
authors.forename: V
authors.initials: V
authors.lastname: Obdrzálek
authors.forename: M
authors.initials: M
authors.lastname: Votava
mesh_terms: D000362:Agar; D000898:Antibiosis; D001430:Bacteriocins / Q000378:metabolism; D002264:Carboxylic Acids / Q000378:metabolism; D003470:Culture Media; D004755:Enterobacteriaceae / Q000254:growth & development*; D004756:Enterobacteriaceae Infections / Q000382:microbiology; D005260:Female; D006094:Gram-Positive Bacteria / Q000254:growth & development*; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D007778:Lactobacillus / Q000254:growth & development* / Q000378:metabolism; D014621:Vagina / Q000382:microbiology*
chemical_list: D001430:Bacteriocins; D002264:Carboxylic Acids; D003470:Culture Media; D000362:Agar; D006861:Hydrogen Peroxide