Variations in white blood count, thromboxane B2 levels and hematocrit in chronic venous hypertension.
OBJECTIVE
To analyze variations in leukocyte count and thromboxane B2 production in the femoral vein of patients with chronic venous hypertension (CVH).


METHODS
Prospective clinical study, controlled, non randomized and open.


METHODS
Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, referral center, university hospital.


METHODS
15 patients with recurring stasis ulcer were analyzed, selected randomly from the venous diseases outpatient center, and 4 without lower limb venous alterations were also analyzed.


METHODS
Blood samples from the femoral and brachial veins were drawn following supine and 45 degrees reverse Trendelenburg.


METHODS
Direct leukocyte count and analysis of the thromboxane B2 with enzyme linked immunosorbent assay test.


RESULTS
After 30 minutes in reverse Trendelenburg, patients with CVH showed a leukocyte count reduced by +/- 27% (p = 0.02) and thromboxane B2 levels increased by +/- 158% (p = 0.02).


CONCLUSIONS
We suggest that future studies of medications for stasis ulcers include their effects on leukocyte entrapment and thromboxane B2 production in the lower limb venous system.
Guimarães
P C
PC
Vascular Surgery Service, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, Brazil. pguimara@uol.com.br
Puech-Leão
P
P
Netto
B M
BM
Wolosker
N
N
Aun
R
R
Yamamoto
L U
LU
D000293:Adolescent; D000328:Adult; D005260:Female; D006400:Hematocrit; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013929:Thromboxane B2 / Q000097:blood* / Q000378:metabolism; D014647:Varicose Ulcer / Q000097:blood* / Q000378:metabolism
D013929:Thromboxane B2