Synthesis and evaluation of artificial taxoids with antitumor and multi-drug resistance reversing activities.
Artificial taxoids were synthesized and subjected to evaluation of their ability of multi-drug resistance reversing and antitumor activities. While the taxoid 4 could not increase cellular accumulation of vincristine in multi-drug resistant tumor cells, the C4-hydroxy analog 15 showed significant effect. However, these compounds showed weak activities on growth inhibition of cancer cells.
Morihira
K
K
Department of Chemistry, Tokyo Institute of Technology, Japan.
Nishimori
T
T
Kusama
H
H
Horiguchi
Y
Y
Kuwajima
I
I
Tsuruo
T
T
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000037:antagonists & inhibitors*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D015195:Drug Design; D018432:Drug Resistance, Multiple; D006801:Humans; D017239:Paclitaxel / Q000031:analogs & derivatives*; D013329:Structure-Activity Relationship
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000970:Antineoplastic Agents; D017239:Paclitaxel