title: Fine needle aspiration of signet-ring cell lymphoma. A case report with differential diagnostic considerations.
abstract: BACKGROUND
  Signet-ring cell lymphoma is an unusual morphologic variant of non-Hodgkin's lymphoma that, although well described histologically, is scarcely mentioned in the cytology literature. Its main significance lies in its potential for diagnostic confusion with more common lesions containing signet-ring cells.
  
  
  METHODS
  A 50-year-old, white male presented with a two-month history of persistent cervical lymphadenopathy and fatigue. Fine needle aspiration of a 2-cm, left, submandibular lymph node revealed classic signet-ring cells among small and large lymphoid cells. Also noted were multivacuolated cells. The background of the smears showed many vacuolated structures analogous to the lymphoglandular bodies seen in lymphoid proliferations without signet-ring cells.
  
  
  CONCLUSIONS
  The differential diagnosis of signet-ring cell lesions by fine needle aspiration includes signet-ring cell lymphoma, sinus histiocytosis and metastatic adenocarcinoma, liposarcoma and melanoma. When confronted with such an aspirate, additional material should be obtained for immunocytochemical or flow cytometric analysis.
authors.affiliation: Department of Laboratory Medicine, Veterans Affairs Medical Center, Minneapolis, Minnesota, USA.
authors.forename: M Z
authors.initials: MZ
authors.lastname: Gilcrease
authors.forename: M
authors.initials: M
authors.lastname: Sahin
authors.forename: R T
authors.initials: RT
authors.lastname: Perri
authors.forename: F S
authors.initials: FS
authors.lastname: Nelson
authors.forename: M
authors.initials: M
authors.lastname: Guzman-Paz
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000473:pathology; D001707:Biopsy, Needle; D018279:Carcinoma, Signet Ring Cell / Q000175:diagnosis* / Q000473:pathology*; D003593:Cytoplasm / Q000473:pathology / Q000648:ultrastructure; D003937:Diagnosis, Differential; D015614:Histiocytosis / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D008080:Liposarcoma / Q000175:diagnosis / Q000473:pathology; D008223:Lymphoma / Q000175:diagnosis* / Q000473:pathology*; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000473:pathology; D008854:Microscopy, Electron; D008875:Middle Aged; D013601:T-Lymphocytes / Q000473:pathology / Q000648:ultrastructure; D014617:Vacuoles / Q000473:pathology / Q000648:ultrastructure