Higher order iminodiacetic acid libraries for probing protein-protein interactions.
Higher order iminodiacetic acid diamide trimer (560 compounds) and tetramer libraries (1260 compounds) are described and were assembled in a convergent multistep solution-phase synthesis for use in studying protein-protein interactions.
Boger
D L
DL
Department of Chemistry, Skaggs Institute for Chemical Biology, Scripps Research Institute, La Jolla, California 92037, USA.
Ducray
P
P
Chai
W
W
Jiang
W
W
Goldberg
J
J
D002614:Chelating Agents / Q000138:chemical synthesis* / Q000737:chemistry; D019992:Databases as Topic; D019281:Dimerization; D015195:Drug Design; D007098:Imino Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D007202:Indicators and Reagents; D008024:Ligands; D008968:Molecular Conformation; D015394:Molecular Structure; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*; D013329:Structure-Activity Relationship
D002614:Chelating Agents; D007098:Imino Acids; D007202:Indicators and Reagents; D008024:Ligands; D011506:Proteins; C008109:iminodiacetic acid