title: Menorrhagia in von Willebrand disease successfully treated with single daily dose tranexamic acid.
abstract: Four cases of menorrhagia in von Willebrand disease were successfully treated with tranexamic acid given in a single daily dose of 4 g for the first 3-5 days of the menstrual cycle. The pathophysiology and pharmacokinetics are discussed. The apparent improved efficacy and acceptability of this new dosing regime have been highlighted.
authors.affiliation: Department of Haematology, Royal Group of Hospitals Trust, Belfast, UK.
authors.forename: Y L
authors.initials: YL
authors.lastname: Ong
authors.forename: D R
authors.initials: DR
authors.lastname: Hull
authors.forename: E E
authors.initials: EE
authors.lastname: Mayne
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000933:Antifibrinolytic Agents / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008595:Menorrhagia / Q000188:drug therapy* / Q000209:etiology; D014148:Tranexamic Acid / Q000627:therapeutic use*; D016896:Treatment Outcome; D014842:von Willebrand Diseases / Q000150:complications*
chemical_list: D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid