title: Update of the Human MitBASE database.
abstract: Human MitBASE is a database collecting human mtDNA variants. This database is part of a greater mitochondrial genome database (MitBASE) funded within the EU Biotech Program. The present paper reports the recent improvements in data structure, data quality and data quantity. As far as the database structure is concerned it is now fully designed and implemented. Based on the previously described structure some changes have been made to optimise both data input and data quality. Cross-references with other bio-databases (EMBL, OMIM, MEDLINE) have been implemented. Human MitBASE data can be queried with the MitBASE Simple Query System (http://www.ebi.ac.uk/htbin/Mitbase/mit base.pl) and with SRS at the EBI under the 'Mutation' section (http://srs.ebi.ac.uk/srs5/). At present the HumanMitBASE node contains approximately 5000 variants related to studies investigating population polymorphisms and pathologies.
authors.affiliation: Dipartimento di Biochimica e Biologia Molecolare, Università degli Studi di Bari, 70126 Bari, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Attimonelli
authors.forename: J M
authors.initials: JM
authors.lastname: Cooper
authors.forename: D
authors.initials: D
authors.lastname: D'Elia
authors.forename: A
authors.initials: A
authors.lastname: de Montalvo
authors.forename: M
authors.initials: M
authors.lastname: De Robertis
authors.forename: H
authors.initials: H
authors.lastname: Lehväslaiho
authors.forename: S B
authors.initials: SB
authors.lastname: Malladi
authors.forename: F
authors.initials: F
authors.lastname: Memeo
authors.forename: K
authors.initials: K
authors.lastname: Stevens
authors.forename: A H
authors.initials: AH
authors.lastname: Schapira
authors.forename: C
authors.initials: C
authors.lastname: Saccone
mesh_terms: D000818:Animals; D004272:DNA, Mitochondrial / Q000235:genetics*; D016208:Databases, Factual / Q000592:standards; D019143:Evolution, Molecular; D030342:Genetic Diseases, Inborn / Q000235:genetics / Q000473:pathology; D014644:Genetic Variation / Q000235:genetics; D006801:Humans; D016247:Information Storage and Retrieval; D020407:Internet; D011110:Polymorphism, Genetic / Q000235:genetics
chemical_list: D004272:DNA, Mitochondrial