title: Primary aortic valve replacement with allografts over twenty-five years: valve-related and procedure-related determinants of outcome.
abstract: OBJECTIVE
  Allografts offer many advantages over prosthetic valves, but allograft durability varies considerably.
  
  
  METHODS
  From 1969 through 1993, 618 patients aged 15 to 84 years underwent their first aortic valve replacement with an aortic allograft. Concomitant surgery included aortic root tailoring (n = 58), replacement or tailoring of the ascending aorta (n = 56), and coronary artery bypass grafting (n = 87). Allograft implantation was done by means of a "freehand" subcoronary technique (n = 551) or total root replacement (n = 67). The allografts were antibiotic sterilized (n = 479), cryopreserved (n = 12), or viable (unprocessed, harvested from brain-dead multiorgan donors or heart transplant recipients, n = 127). Maximum follow-up was 27.1 years.
  
  
  RESULTS
  Thirty-day mortality was 5.0%, and crude survival was 67% and 35% at 10 and 20 years. Ten- and 20-year rates of freedom from complications were as follows: endocarditis, 93% and 89%; primary tissue failure, 62% and 18%; and redo aortic valve replacement, 81% and 35%. Multivariable Cox analyses identified several valve- and procedure-related determinants: rising allograft donor age and antibiotic-sterilized allograft for mortality; donor more than 10 years older than patient for endocarditis; rising donor age minus patient age, rising implantation time (from harvest to aortic valve replacement), and donor age more than 65 years for tissue failure; and rising donor age minus patient age, young patient age, rising implantation time, and subcoronary implantation preceded by aortic root tailoring for redo aortic valve replacement. Estimated 10- and 20-year rates of freedom from tissue failure for a 70-year-old patient with a viable valve from a 30-year-old donor and no other risk factors were 91% and 64%; the figures were 71% and 20% if the donor age was 65 years. The rates of freedom from tissue failure for a 30-year-old patient with a 30-year-old donor were 82% and 39%; the figures were 49% and 3% with a 65-year-old donor. Beneficial influences of a viable valve were largely covered by short harvest time (no delay for allografts from brain dead organ donors or heart transplant recipients) and short implantation time.
  
  
  CONCLUSIONS
  Primary allograft aortic valve replacement can give acceptable results for up to 25 years. The late results can be improved by the use of a viable allograft, by matching patient and donor age, and by more liberal use of free root replacement with re-implantation of the coronary arteries rather than tailoring the root to accommodate a subcoronary implantation.
authors.affiliation: Academic Department of Cardiac Surgery, Harefield Hospital, Middlesex, United Kingdom.
authors.forename: O
authors.initials: O
authors.lastname: Lund
authors.forename: V
authors.initials: V
authors.lastname: Chandrasekaran
authors.forename: R
authors.initials: R
authors.lastname: Grocott-Mason
authors.forename: H
authors.initials: H
authors.lastname: Elwidaa
authors.forename: R
authors.initials: R
authors.lastname: Mazhar
authors.forename: A
authors.initials: A
authors.lastname: Khaghani
authors.forename: A
authors.initials: A
authors.lastname: Mitchell
authors.forename: C
authors.initials: C
authors.lastname: Ilsley
authors.forename: M H
authors.initials: MH
authors.lastname: Yacoub
mesh_terms: D000368:Aged; D001011:Aorta / Q000601:surgery; D001021:Aortic Valve / Q000637:transplantation*; D001022:Aortic Valve Insufficiency / Q000401:mortality / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000401:mortality / Q000601:surgery*; D019917:Blood Vessel Prosthesis Implantation; D002315:Cardiopulmonary Bypass; D004696:Endocarditis / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D016019:Survival Analysis; D014184:Transplantation, Homologous; D016896:Treatment Outcome