Cytogenetics of benign breast lesions.
This review summarizes the cytogenetic information on benign breast lesions of various histologies, i.e., fibrocystic lesions from women with and without a known hereditary predisposition to breast cancer, fibroadenomas, phyllodes tumors, and papillomas, and relate the chromosomal features with those in breast carcinoma. In general, the frequency of chromosome abnormalities is lower in benign lesions than in breast cancer, and seems to correlate with the histologic features of the tissue, and the corresponding risk of developing invasive mammary carcinoma; aberrations are more common in proliferative than in nonproliferative lesions. The karyotypes are generally less complex than those detected in invasive carcinoma, and more often involve balanced rearrangements. No lesion-specific aberration has so far been detected; on the contrary, changes repeatedly encountered in breast cancer samples can be found in benign lesions as well, e.g., gain of 1q, interstitial deletion of 3p, and trisomies 7, 18, and 20. Especially intriguing is the prevalence of rearrangements of the short arm of chromosome 3, with the minimally deleted bands 3p13-14, in proliferative lesions from prophylactic mastectomies in breast cancer families. The potential tumor suppressor gene(s) in this region remains, however, to be identified.
Lundin
C
C
Department of Clinical Genetics, Uppsala University Hospital, Sweden. catarina.lundin@klingen.uu.se
Mertens
F
F
D001941:Breast Diseases / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology*; D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D002869:Chromosome Aberrations / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D025063:Chromosome Disorders; D005260:Female; D005348:Fibrocystic Breast Disease / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D006801:Humans; D007621:Karyotyping