Synovium in haemophilic arthropathy.
Synovium is an essential component of the joint and plays a critical role in maintaining a balance between physiological processes and pathological changes in the joint. Recurrent intra-articular bleeding as occur in haemophilia induce pathological synovial changes in the joint. From a certain point on, synovitis inevitably plays a major role in joint destruction, although in the early phase of haemophilic arthropathy its role may be secondary to cartilage damage as a result of the direct effects of blood on cartilage. The changed haemosiderotic, synovial tissue produces catabolic cytokines and enzymes harmful for cartilage.
Roosendaal
G
G
Van Creveld Clinic, National Haemophilia Centre, University Hospital Utrecht, Utrecht, The Netherlands. G.Roosendaal@digd.azu.nl
Mauser-Bunschoten
E P
EP
De Kleijn
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P
Heijnen
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L
van den Berg
H M
HM
Van Rinsum
A C
AC
Lafeber
F P
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Bijlsma
J W
JW
D002356:Cartilage / Q000378:metabolism / Q000473:pathology; D006467:Hemophilia A / Q000378:metabolism / Q000473:pathology*; D006485:Hemosiderin / Q000378:metabolism; D006801:Humans; D013583:Synovial Membrane / Q000378:metabolism / Q000473:pathology*
D006485:Hemosiderin