Synthesis and biological evaluation of novel 2-[substituted acetyl]-amino-5-alkyl-1,3,4-thiadiazoles [corrected].
Sixteen novel 2-substituted acetyl amino-5-alkyl-1,3,4-thiadiazole were synthesized and screened for their pharmacological activities. A few of the compounds namely 11, 12 and 16 showed anti-inflammatory activities comparable to phenylbutazone. Compound 12 also showed significant non-specific spasmolytic activity. Diuretic activity of compound 15 at a dose level of 90 mg/kg p.o. was two fold higher compared to 50 mg/kg p.o. of furosemide. Comparable diuresis was also produced by compounds 9, 10 and 16.
Shakya
A K
AK
Clinical Pharmacology & Pharmacokinetics Ranbaxy Research Laboratories, Gurgoan, Haryana, India.
Mishra
P
P
Patnaik
G K
GK
Shukla
R
R
Srimal
R C
RC
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002415:Cats; D004232:Diuretics / Q000138:chemical synthesis / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010276:Parasympatholytics / Q000138:chemical synthesis / Q000494:pharmacology*; D013830:Thiadiazoles / Q000138:chemical synthesis / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D004232:Diuretics; D010276:Parasympatholytics; D013830:Thiadiazoles