Rotavirus.
Rotavirus, the most common diarrheal pathogen in children worldwide, causes approximately one third of diarrhea-associated hospitalizations and 800,000 deaths per year. Because natural infection reduces the incidence and severity of subsequent episodes, rotavirus diarrhea might be controlled through vaccination. Serotypespecific immunity may play a role in protection from disease. Tetravalent rhesus-human reassortant rotavirus vaccine (RRV-TV) (which contains a rhesus rotavirus with serotype G3 specificity and reassortant rhesus-human rotaviruses with G1, G2, and G4 specificity) provides coverage against the four common serotypes of human rotavirus. In clinical trials in industrialized countries, RRV-TV conferred 49% to 68% protection against any rotavirus diarrhea and 61% to 100% protection against severe disease. This vaccine was licensed by the U.S. Food and Drug Administration on August 31, 1998, and should be cost-effective in reducing diarrheal diseases in industrialized countries. The vaccine's efficacy and cost-effectiveness in developing countries should be evaluated.
Parashar
U D
UD
Viral Gastroenteritis Section, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. uap2@cdc.gov
Bresee
J S
JS
Gentsch
J R
JR
Glass
R I
RI
D000818:Animals; D006801:Humans; D012401:Rotavirus / Q000276:immunology / Q000648:ultrastructure; D012400:Rotavirus Infections / Q000453:epidemiology / Q000276:immunology / Q000503:physiopathology / Q000517:prevention & control*; D014765:Viral Vaccines / Q000276:immunology*
D014765:Viral Vaccines