title: Nonepisodic angioedema associated with eosinophilia: report of 4 cases and review of 33 young female patients reported in Japan.
abstract: BACKGROUND
  In 1984, Gleich et al. described 4 patients with episodic angioedema associated with eosinophilia (EAE), which was characterized by recurrent episodes of angioedema and urticaria, eosinophilia, elevated serum IgM, fever, increased body weight and a benign course without involvement of the internal organs demonstrating that it was a clinical entity distinct from the hypereosinophilic syndrome. Thereafter, 37 cases of EAE have been reported in Japan, 33 cases of which, although similar, had a different evolution from classical EAE.
  
  
  OBJECTIVE
  To describe 4 cases and review the cases of angioedema associated with eosinophilia reported in Japan.
  
  
  RESULTS
  Four Japanese female patients had persistent angioedema mainly involving the hands and lower legs, and eosinophilia which resolved within a few months. The review of the 37 cases of EAE in the Japanese literature demonstrated that in 33 cases, there were common characteristics which differed from EAE. These included: (1) the absence of recurrent attacks; (2) the predominance of young females (20-37 years, with a mean of 26 years); (3) the localization of the angioedema to the extremities; (4) the absence of increase in the serum IgM level, and (5) the effectiveness of low-dose prednisone or even the occurrence of spontaneous remission.
  
  
  CONCLUSIONS
  We propose that persistent angioedema with eosinophilia can be classified into 2 types, i.e. one being an episodic (recurrent) type as reported by Gleich and a nonepisodic type as our 4 cases and others found in the Japanese literature.
authors.affiliation: Department of Dermatology, Tohoku University School of Medicine, Sendai Teishin Hospital, Sendai, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Chikama
authors.forename: M
authors.initials: M
authors.lastname: Hosokawa
authors.forename: T
authors.initials: T
authors.lastname: Miyazawa
authors.forename: R
authors.initials: R
authors.lastname: Miura
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: H
authors.initials: H
authors.lastname: Tagami
mesh_terms: D000328:Adult; D000799:Angioedema / Q000097:blood / Q000150:complications* / Q000473:pathology; D004802:Eosinophilia / Q000097:blood / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000473:pathology