[Activity of elastase and its inhibitors in arterial tissues and blood serum under experimental arterio-atherosclerosis].
The role of the elastolytic system serum and arterial tissues in pathogenesis of vascular pathology was investigated on rabbits in experimental arterio-atherosclerosis. Activation of proteolytic enzymes, in particular elastase, sharp alteration capacity of inhibitors in arterial wall both at Menckeberg arteriosclerosis and atherosclerosis, permits to assume, that in the basis these different pathologic processes can lie general mechanisms, which will be realized through disturbance of the elastolytic system balance in blood vessels.
Dosenko
V Ie
VIe
O.O. Bogomolets National Medical University, Kyiv Ministry of Public Health of Ukraine.
D000818:Animals; D001158:Arteries / Q000378:metabolism; D001161:Arteriosclerosis / Q000139:chemically induced / Q000201:enzymology / Q000378:metabolism*; D002784:Cholesterol / Q000633:toxicity; D004573:Electrolytes / Q000097:blood / Q000378:metabolism; D004872:Ergocalciferols / Q000633:toxicity; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors / Q000097:blood / Q000378:metabolism*; D011817:Rabbits; D015842:Serine Proteinase Inhibitors / Q000097:blood / Q000378:metabolism*
D004573:Electrolytes; D004872:Ergocalciferols; D015842:Serine Proteinase Inhibitors; D002784:Cholesterol; D010196:Pancreatic Elastase
Aktyvnist' elastazy ta ïï inhibitoriv u tkanynakh arteriĭ ta syrovatsi krovi za umov eksperymental'noho arterio-ateroskelrozu.