title: Premature sexual development in children following the use of estrogen- or placenta-containing hair products.
abstract: Four African-American girls aged 14 months to 93 months developed breast or pubic hair 2 to 24 months after starting the use of estrogen or placenta-containing hair products. Discontinuing the use of the hair products resulted in regression of the breast or pubic hair. Serum gonadotropins and estradiol levels were variable. No other cause for early sexual development was noted in these girls.
authors.affiliation: Department of Pediatrics, Brooke Army Medical Center, Ft. Sam Houston, TX 78234, USA.
authors.forename: C M
authors.initials: CM
authors.lastname: Tiwary
mesh_terms: D002648:Child; D002675:Child, Preschool; D004967:Estrogens / Q000009:adverse effects*; D005260:Female; D006197:Hair / Q000187:drug effects; D006203:Hair Preparations / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D008297:Male; D010924:Placental Extracts / Q000009:adverse effects*; D011629:Puberty, Precocious / Q000139:chemically induced; D012741:Sexual Maturation / Q000187:drug effects*
chemical_list: D004967:Estrogens; D006203:Hair Preparations; D010924:Placental Extracts