title: Design of novel tripeptides with macrophage migration-enhancing activity.
abstract: A new approach to the generation of biologically active peptides from non-peptide lead was demonstrated. C,N-termini protected Phe-Phe-His derivatives possessing macrophage migration-enhancing activity were designed on the basis of the structure of imidazoline derivative 1, and these structure-activity relationships were also described.
authors.affiliation: Medicinal Chemistry Research Laboratory, Discovery Research Laboratories, Tanabe Seiyaku Co., Ltd., Saitama, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nunami
authors.forename: M
authors.initials: M
authors.lastname: Yamada
authors.forename: R
authors.initials: R
authors.lastname: Shimizu
mesh_terms: D002465:Cell Movement / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D015195:Drug Design; D008262:Macrophage Activation / Q000187:drug effects*; D009842:Oligopeptides / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D009842:Oligopeptides