title: Leptospirosis in an urban setting: case report and review of an emerging infectious disease.
abstract: Leptospiosis is a common zoonosis affecting most mammals. Leptospirosis has protean manifestations ranging from a flu-like illness to fulminant hepatic and renal failure culminating in death. Although the diagnosis is often not considered upon presentation, the literature suggests that leptospirosis is a reemerging infectious disease in urban centers throughout the industrialized world. It will be incumbent upon Emergency Physicians to include this spirochetal disease in the differential diagnosis of febrile patients with appropriate risk factors and symptomatology. We present the case of a 36 year-old woman who presented to the Emergency Department with fever and hypotension. We review the literature on leptospirosis with specific focus on risk factors and pathogenesis, clinical manifestations, diagnosis, treatment, and outcome.
authors.affiliation: Department of Emergency Medicine, Rhode Island Hospital and Brown University School of Medicine, Providence 02903, USA.
authors.forename: W D
authors.initials: WD
authors.lastname: Binder
authors.forename: L A
authors.initials: LA
authors.lastname: Mermel
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000963:Antimetabolites / Q000627:therapeutic use; D004318:Doxycycline / Q000627:therapeutic use; D004636:Emergency Service, Hospital; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007919:Leptospira / Q000302:isolation & purification*; D007922:Leptospirosis / Q000175:diagnosis* / Q000188:drug therapy*; D012254:Ribavirin / Q000627:therapeutic use; D016896:Treatment Outcome; D014505:Urban Population
chemical_list: D000900:Anti-Bacterial Agents; D000963:Antimetabolites; D012254:Ribavirin; D004318:Doxycycline