title: Prevention of peritonitis with disconnect systems in CAPD: a randomized controlled trial. The Mexican Nephrology Collaborative Study Group.
abstract: BACKGROUND
  Recently, disconnect systems for CAPD that are associated with a reduced frequency of peritonitis have been introduced. Our objective was to compare the incidence of peritonitis using three current CAPD systems in a high-risk population with low educational and socioeconomic levels, and high prevalence of malnutrition.
  
  
  METHODS
  In a prospective controlled trial, 147 patients commencing CAPD were randomly assigned to one of three groups: 29 to the conventional, 57 to the Y-set, and 61 to the twin bag systems. The number of peritonitis episodes was registered, and patients were followed up for an average of 11.3 months.
  
  
  RESULTS
  The average peritonitis-free interval for the conventional group was 6.1 months, for the Y system was 12.0 months, and for the twin bag was 24.8 months (P < 0.001). By multivariate analysis, the only factor associated with peritonitis was the CAPD system. Peritonitis-related hospitalization was 5.3 +/- 2.0, 2.7 +/- 1.0, and 1.5 +/- 0.9 days/patient/year in the conventional, Y system, and twin bag groups, respectively. The cost per bag was similar for the conventional and Y system, but higher for the twin bag. However, the total costs of treatment (pesos/patient/year) were lower for twin bag (62,159 for the conventional, 70,275 for the Y system, and 54,387 for the twin bag), due to the lower peritonitis incidence and associated hospitalizations.
  
  
  CONCLUSIONS
  Y system and twin bag use was associated with a reduction of 50 and 75% peritonitis incidence, respectively, in patients on CAPD. The cost of the twin bag was actually lower, because of savings from a decreased usage of antibiotics and fewer hospitalizations.
authors.forename: F
authors.initials: F
authors.lastname: Monteón
authors.forename: R
authors.initials: R
authors.lastname: Correa-Rotter
authors.forename: R
authors.initials: R
authors.lastname: Paniagua
authors.forename: D
authors.initials: D
authors.lastname: Amato
authors.forename: M E
authors.initials: ME
authors.lastname: Hurtado
authors.forename: J L
authors.initials: JL
authors.lastname: Medina
authors.forename: R M
authors.initials: RM
authors.lastname: Salcedo
authors.forename: E
authors.initials: E
authors.lastname: García
authors.forename: M
authors.initials: M
authors.lastname: Matos
authors.forename: J
authors.initials: J
authors.lastname: Kaji
authors.forename: R
authors.initials: R
authors.lastname: Vázquez
authors.forename: A
authors.initials: A
authors.lastname: Ramos
authors.forename: M A
authors.initials: MA
authors.lastname: Schettino
authors.forename: J
authors.initials: J
authors.lastname: Moran
mesh_terms: D000328:Adult; D004867:Equipment Design; D005260:Female; D017048:Health Care Costs; D006760:Hospitalization; D006801:Humans; D015994:Incidence; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects* / Q000191:economics / Q000295:instrumentation / Q000379:methods*; D010538:Peritonitis / Q000453:epidemiology / Q000517:prevention & control*; D011446:Prospective Studies