Carbon monoxide and vascular cell function (review).
Carbon monoxide (CO) is an endogenously generated gas that may play an important physiological role in the circulation. CO is generated by vascular cells as a byproduct of heme catabolism, in which heme oxygenase (HO) catalyzes the degradation of heme to biliverdin, iron and CO. Two distinct isoforms of HO have been identified in vascular tissue. The HO-2 isoform is constitutively expressed and likely mediates the release of CO under normal physiologic conditions. In contrast, the HO-1 isoform is strongly induced in vascular cells by various stress-associated agents and markedly increases CO synthesis during pathological conditions. The release of CO by vascular cells exerts both paracrine and autocrine effects on vascular smooth muscle cells (SMC) and circulating blood cells. CO regulates blood flow and blood fluidity by inhibiting vasomotor tone, SMC proliferation, and platelet aggregation. These vascular effects of CO are mediated via the activation of soluble guanylate cyclase and the consequent rise in intracellular guanosine 3',5'-cyclic monophosphate levels in target tissues. CO may also play a role in various cardiovascular disorders, including endotoxin shock, ischemia-reperfusion, hypertension, and subarachnoid hemorrhage. This review will focus on the recent progress made in understanding the regulation and function of CO in the vasculature.
Durante
W
W
Department of Medicine, Houston VA Medical Center, TX, USA.
Schafer
A I
AI
D000818:Animals; D019898:Autocrine Communication; D001808:Blood Vessels / Q000378:metabolism / Q000502:physiology*; D002248:Carbon Monoxide / Q000378:metabolism / Q000502:physiology*; D006418:Heme / Q000378:metabolism; D006801:Humans; D009129:Muscle Tonus; D009131:Muscle, Smooth, Vascular / Q000378:metabolism / Q000502:physiology*; D032389:Myocytes, Smooth Muscle / Q000378:metabolism*; D019899:Paracrine Communication; D014652:Vascular Diseases / Q000378:metabolism / Q000503:physiopathology
D006418:Heme; D002248:Carbon Monoxide