Positron emission tomography (PET) methodology for small animals and its application in radiopharmaceutical preclinical investigation.
The use and usefulness of positron emission tomography (PET) to quantify the specific and selective in vivo binding of radioligands in small laboratory animals is briefly reviewed up to the end of 1996. Emphasis is placed on practical experience with a dedicated, small diameter, tomograph (built in collaboration with CTI, Knoxville, TN), implementing conventional PET methodology.
Hume
S P
SP
Cyclotron Unit, MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Jones
T
T
D000818:Animals; D002250:Carbon Radioisotopes; D011869:Radioligand Assay / Q000379:methods*; D019275:Radiopharmaceuticals / Q000378:metabolism*; D051381:Rats; D014055:Tomography, Emission-Computed / Q000295:instrumentation*
D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals