title: Transient neonatal hypothyroidism after gestational exposure to amiodarone: a follow-up of two cases.
abstract: Amiodarone (AMD) is an antiarrhythmic drug which contains 37% of iodine. It can reach the fetus by transplacental passage and induce fetal hypothyroidism. Since in some pregnant women AMD represents a cardinal therapeutic opportunity, it is necessary to establish not only the risk of teratogenicity linked to fetal AMD exposure but also to evaluate the psychomotor development of children with neonatal thyroid dysfunction related to fetal AMD exposure. We report on two cases involving children with an AMD gestational exposure and transient neonatal hypothyroidism, who were followed-up until the age of 4 years 8 months and 5 years 6 months, respectively. Denver's developmental milestone test and Whechsler Preschool and Primary Scale of Intelligence (WPPSI) were administered to the patients in accordance to their age. A normal psychomotor development was observed in both patients with full scale IQ score, verbal and performance IQ scores within normal range. In conclusion, if these data were validated by larger studies, it might not be obligatory to discontinue AMD administration in cardiopathic pregnant women, since mental impairment may not necessarily occur in children with transient neonatal hypothyroidism caused by fetal AMD exposure. However, the evaluation of the thyroid function of these children is imperative.
authors.affiliation: Istituto di Clinica Pediatrica, University of Siena, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Grosso
authors.forename: R
authors.initials: R
authors.lastname: Berardi
authors.forename: M
authors.initials: M
authors.lastname: Cioni
authors.forename: G
authors.initials: G
authors.lastname: Morgese
mesh_terms: D000328:Adult; D000638:Amiodarone / Q000009:adverse effects*; D005260:Female; D005315:Fetal Diseases / Q000139:chemically induced*; D006801:Humans; D007037:Hypothyroidism / Q000139:chemically induced*; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011597:Psychomotor Performance
chemical_list: D000638:Amiodarone