title: Dynamics of human immunodeficiency virus type 1 replication in vertically infected infants.
abstract: Plasma human immunodeficiency virus type 1 (HIV-1) turnover and kinetics were studied in children aged 15 days to 2 years following the initiation of a triple antiretroviral drug regimen consisting of zidovudine, lamivudine, and nevirapine. HIV-1 turnover was at least as rapid as that previously described in adults; turnover rates were more rapid in infants and children aged 3 months to 2 years than in infants less than 3 months of age. These data confirm the central role of HIV-1 replication in the pathogenesis of vertical HIV-1 infection and reinforce the importance of early, potent combination therapies for the long-term control of HIV-1 replication.
authors.affiliation: Department of Pediatrics, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Boston, Massachusetts, USA. katherine.luzuriaga@ummed.edu
authors.forename: K
authors.initials: K
authors.lastname: Luzuriaga
authors.forename: H
authors.initials: H
authors.lastname: Wu
authors.forename: M
authors.initials: M
authors.lastname: McManus
authors.forename: P
authors.initials: P
authors.lastname: Britto
authors.forename: W
authors.initials: W
authors.lastname: Borkowsky
authors.forename: S
authors.initials: S
authors.lastname: Burchett
authors.forename: B
authors.initials: B
authors.lastname: Smith
authors.forename: L
authors.initials: L
authors.lastname: Mofenson
authors.forename: J L
authors.initials: JL
authors.lastname: Sullivan
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy / Q000635:transmission / Q000821:virology*; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D014766:Viremia / Q000188:drug therapy / Q000821:virology*; D014779:Virus Replication
chemical_list: D019380:Anti-HIV Agents