title: Synthesis and antitumor activity of 4-phenyl-1-arylsulfonyl imidazolidinones.
abstract: Novel 1-(1-benzoylindoline-5-sulfonyl)-4-phenyl-4,5-dihydroimidazolon es 3 synthesized show highly potent and broad cytotoxicities. Among them compound 3b (DW2143) exhibits much more potent cytotoxicities than doxorubicin and highly effective antitumor activities against murine (3LL, Colon 26) and human xenograft (NCI-H23, SW620) tumor models.
authors.affiliation: College of Pharmacy, Chungnam National University, Taejon, Korea.
authors.forename: S H
authors.initials: SH
authors.lastname: Jung
authors.forename: H S
authors.initials: HS
authors.lastname: Lee
authors.forename: J S
authors.initials: JS
authors.lastname: Song
authors.forename: H M
authors.initials: HM
authors.lastname: Kim
authors.forename: S B
authors.initials: SB
authors.lastname: Han
authors.forename: C W
authors.initials: CW
authors.lastname: Lee
authors.forename: M
authors.initials: M
authors.lastname: Lee
authors.forename: D R
authors.initials: DR
authors.lastname: Choi
authors.forename: J A
authors.initials: JA
authors.lastname: Lee
authors.forename: Y H
authors.initials: YH
authors.lastname: Chung
authors.forename: S J
authors.initials: SJ
authors.lastname: Yoon
authors.forename: E Y
authors.initials: EY
authors.lastname: Moon
authors.forename: H S
authors.initials: HS
authors.lastname: Hwang
authors.forename: S K
authors.initials: SK
authors.lastname: Seong
authors.forename: D K
authors.initials: DK
authors.lastname: Lee
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D051379:Mice; D013450:Sulfones / Q000138:chemical synthesis / Q000494:pharmacology; D014183:Transplantation, Heterologous; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D007093:Imidazoles; D013450:Sulfones; C116727:DW 2143