Carbachol, an acetylcholine receptor agonist, enhances production in rat aorta of 2-arachidonoyl glycerol, a hypotensive endocannabinoid.
The production of 2-arachidonoyl glycerol, an endogenous cannabinoid, is enhanced in normal, but not in endothelium-denuded rat aorta on stimulation with carbachol, an acetylcholine receptor agonist. 2-Arachidonoyl glycerol potently reduces blood pressure in rats and may represent an endothelium-derived hypotensive factor.
Mechoulam
R
R
Hebrew University, School of Pharmacy, Medical Faculty, Jerusalem, Israel. mechou@yam-suff.cc.huji.ac.il
Fride
E
E
Ben-Shabat
S
S
Meiri
U
U
Horowitz
M
M
D000818:Animals; D001011:Aorta / Q000187:drug effects* / Q000378:metabolism; D001095:Arachidonic Acids; D001794:Blood Pressure / Q000187:drug effects*; D063385:Cannabinoid Receptor Modulators; D002217:Carbachol / Q000494:pharmacology*; D018679:Cholinergic Agonists / Q000494:pharmacology; D063388:Endocannabinoids; D004730:Endothelium, Vascular / Q000187:drug effects*; D005989:Glycerides / Q000378:metabolism*; D007022:Hypotension / Q000139:chemically induced; D066298:In Vitro Techniques; D008297:Male; D051381:Rats
D001095:Arachidonic Acids; D063385:Cannabinoid Receptor Modulators; D018679:Cholinergic Agonists; D063388:Endocannabinoids; D005989:Glycerides; C094503:glyceryl 2-arachidonate; D002217:Carbachol