Feasibility study of lactate imaging of head and neck tumors.
A proton spectroscopic imaging sequence was used to investigate the feasibility of lactate imaging in head and neck tumors. The sequence employs a two-shot lactate editing method with inversion recovery for additional lipid suppression, and a restricted field of view to suppress motion artifacts. Variations in acquisition parameters and two different receive coils were investigated on twelve patients. Elevated lactate was detected in three patients, no lactate was observed in seven patients, and two studies were inconclusive because of severe motion or inhomogeneity artifacts. Best results were obtained with an anterior/posterior neck coil at a 288 ms echo time (TE).
Adalsteinsson
E
E
Department of Radiology, Stanford University, CA 94305-5488, USA. elfar@lad.stanford.edu
Spielman
D M
DM
Pauly
J M
JM
Terris
D J
DJ
Sommer
G
G
Macovski
A
A
D000328:Adult; D000368:Aged; D005240:Feasibility Studies; D005260:Female; D006258:Head and Neck Neoplasms / Q000737:chemistry* / Q000473:pathology / Q000601:surgery; D006801:Humans; D019344:Lactic Acid / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged
D019344:Lactic Acid