Synthesis and biological evaluation of new tetrahydronaphthalene derivatives as thromboxane receptor antagonists.
New polysubstituted tetrahydronaphthalene derivatives were prepared as thromboxane receptor (TP-receptor) antagonists. Within this series of compounds S 18886 has been identified as an orally active, highly potent antagonist with a very long duration of action in different species.
Cimetière
B
B
Institut de Recherches Servier, Centre de Recherches de Croissy, Croissy-sur-Seine, France.
Dubuffet
T
T
Muller
O
O
Descombes
J J
JJ
Simonet
S
S
Laubie
M
M
Verbeuren
T J
TJ
Lavielle
G
G
D000818:Animals; D006168:Guinea Pigs; D006801:Humans; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D011312:Pressure; D011817:Rabbits; D017482:Receptors, Thromboxane / Q000037:antagonists & inhibitors*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology*; D013764:Tetrahydronaphthalenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D014132:Trachea / Q000187:drug effects / Q000502:physiology
D010975:Platelet Aggregation Inhibitors; D017482:Receptors, Thromboxane; C117559:S 1886; D013449:Sulfonamides; D013764:Tetrahydronaphthalenes