title: Nonpeptide oxytocin antagonists: potent, orally bioavailable analogs of L-371,257 containing a 1-R-(pyridyl)ethyl ether terminus.
abstract: Structure-activity studies on the oxytocin antagonist 1 (L-371,257) have identified a new series of high affinity, receptor-selective OT antagonists in which the N-acetyl-4-piperidinyl ether terminus in 1 has been replaced with a 1-(aryl)ethoxy group.
authors.affiliation: Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA.
authors.forename: M S
authors.initials: MS
authors.lastname: Kuo
authors.forename: M G
authors.initials: MG
authors.lastname: Bock
authors.forename: R M
authors.initials: RM
authors.lastname: Freidinger
authors.forename: M T
authors.initials: MT
authors.lastname: Guidotti
authors.forename: E V
authors.initials: EV
authors.lastname: Lis
authors.forename: J M
authors.initials: JM
authors.lastname: Pawluczyk
authors.forename: D S
authors.initials: DS
authors.lastname: Perlow
authors.forename: D J
authors.initials: DJ
authors.lastname: Pettibone
authors.forename: A G
authors.initials: AG
authors.lastname: Quigley
authors.forename: D R
authors.initials: DR
authors.lastname: Reiss
authors.forename: P D
authors.initials: PD
authors.lastname: Williams
authors.forename: C J
authors.initials: CJ
authors.lastname: Woyden
mesh_terms: D000284:Administration, Oral; D000818:Animals; D048588:Benzoxazines; D001682:Biological Availability; D005260:Female; D006801:Humans; D010078:Oxazines / Q000494:pharmacology*; D010121:Oxytocin / Q000037:antagonists & inhibitors*; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D048588:Benzoxazines; C096766:L 371257; D010078:Oxazines; D010880:Piperidines; D010121:Oxytocin