Improved stability of highly fluorinated phospholipid-based vesicles in the presence of bile salts.
The stability of fluorinated phospholipid-based vesicles in terms of detergent-induced release of encapsulated carboxyfluorescein has been evaluated. The fluorinated liposomes are substantially more resistant towards the lytic action of sodium taurocholate than conventional DSPC or even DSPC/CH 1/1 liposomes. Concerning structure/permeability relationships, the larger the fluorination degree of the membrane, the higher the resistance of the fluorinated liposomes to their destruction by the detergent. These results show that fluorinated liposomes have a promising potential as drug carrier and delivery systems for oral administration.
Gadras
C
C
Laboratoire de Chimie Bio-Organique, ESA 6001 CNRS, Université de Nice Sophia-Antipolis, Faculté des Sciences, 06108 Nice Cédex 2, France.
Santaella
C
C
Vierling
P
P
D001647:Bile Acids and Salts / Q000737:chemistry*; D003902:Detergents; D005452:Fluoresceins / Q000737:chemistry*; D005456:Fluorescent Dyes; D006207:Half-Life; D008081:Liposomes; D010539:Permeability; D010713:Phosphatidylcholines; D010743:Phospholipids / Q000737:chemistry*; D013656:Taurocholic Acid
D001647:Bile Acids and Salts; D003902:Detergents; D005452:Fluoresceins; D005456:Fluorescent Dyes; D008081:Liposomes; D010713:Phosphatidylcholines; D010743:Phospholipids; C070167:di-(8-methylstearoyl)phosphatidylcholine; C024098:6-carboxyfluorescein; D013656:Taurocholic Acid