title: Characterisation of a novel AGE-compound derived from lysine and 3-deoxyglucosone.
abstract: Dicarbonyl compounds are supposed to be reactive intermediates in the non-enzymatic glycation of proteins. A process that eventually could lead to the development of late diabetic complications. Glyoxal lysine dimer (GOLD) and methylglyoxal lysine dimer (MOLD) have previously been described as such reactive dicarbonyls. Here a new compound 3-deoxyglucosone lysine dimer (DOLD), a cross-link resulting from the reaction between hippuryl-lysine and 3-deoxyglucosone, has been isolated by HPLC and the structure determined by mass spectrometry and NMR.
authors.affiliation: Health Care Discovery, Novo Nordisk A/S, Bagsvaerd, Denmark.
authors.forename: I C
authors.initials: IC
authors.lastname: Skovsted
authors.forename: M
authors.initials: M
authors.lastname: Christensen
authors.forename: J
authors.initials: J
authors.lastname: Breinholt
authors.forename: S B
authors.initials: SB
authors.lastname: Mortensen
mesh_terms: D002851:Chromatography, High Pressure Liquid; D003432:Cross-Linking Reagents; D003847:Deoxyglucose / Q000031:analogs & derivatives* / Q000737:chemistry; D017127:Glycation End Products, Advanced / Q000737:chemistry / Q000302:isolation & purification*; D008239:Lysine / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015416:Maillard Reaction; D015394:Molecular Structure; D016339:Spectrometry, Mass, Fast Atom Bombardment
chemical_list: D003432:Cross-Linking Reagents; D017127:Glycation End Products, Advanced; D003847:Deoxyglucose; C016350:3-deoxyglucosone; D008239:Lysine