title: Solid phase organic synthesis of polyamine derivatives and initial biological evaluation of their antitumoral activity.
abstract: A series of N1-monosubstituted putrescine and spermine derivatives was synthesised using a solid phase methodology. We evaluated their cytotoxicity, calmodulin antagonism and polyamine uptake inhibition, pharmacological properties shared by some antitumoral agents.
authors.affiliation: Pharmacochimie de Molécules de Synthèse et de Produits Naturels, Faculté de Pharmacie, Rennes, France.
authors.forename: S
authors.initials: S
authors.lastname: Tomasi
authors.forename: M
authors.initials: M
authors.lastname: Le Roch
authors.forename: J
authors.initials: J
authors.lastname: Renault
authors.forename: J C
authors.initials: JC
authors.lastname: Corbel
authors.forename: P
authors.initials: P
authors.lastname: Uriac
authors.forename: B
authors.initials: B
authors.lastname: Carboni
authors.forename: D
authors.initials: D
authors.lastname: Moncoq
authors.forename: B
authors.initials: B
authors.lastname: Martin
authors.forename: J G
authors.initials: JG
authors.lastname: Delcros
mesh_terms: D006631:Amine Oxidase (Copper-Containing); D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002147:Calmodulin / Q000037:antagonists & inhibitors; D002417:Cattle; D002470:Cell Survival / Q000187:drug effects; D003641:Deamination; D007939:Leukemia L1210 / Q000378:metabolism / Q000473:pathology; D008956:Models, Chemical; D010084:Oxidation-Reduction; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000378:metabolism; D011700:Putrescine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D013096:Spermine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D002147:Calmodulin; D013096:Spermine; D006631:Amine Oxidase (Copper-Containing); D000587:Oxidoreductases Acting on CH-NH Group Donors; D011700:Putrescine