title: Non-peptidic HIV protease inhibitors: C2-symmetry-based design of bis-sulfonamide dihydropyrones.
abstract: Potent, non-peptidic, dihydropyrone sulfonamide HIV protease inhibitors have been previously described. Crystallographic analysis of dihydropyrone sulfonamide inhibitor/HIV protease complexes suggested incorporation of a second, C2 symmetry-related sulfonamide group. Selected bis-sulfonamide dihydropyrone analogues display high HIV protease inhibitory activity.
authors.affiliation: Pharmacia & Upjohn, Inc., Kalamazoo, Michigan 49001, USA.
authors.forename: M N
authors.initials: MN
authors.lastname: Janakiraman
authors.forename: K D
authors.initials: KD
authors.lastname: Watenpaugh
authors.forename: P K
authors.initials: PK
authors.lastname: Tomich
authors.forename: K T
authors.initials: KT
authors.lastname: Chong
authors.forename: S R
authors.initials: SR
authors.lastname: Turner
authors.forename: R A
authors.initials: RA
authors.lastname: Tommasi
authors.forename: S
authors.initials: S
authors.lastname: Thaisrivongs
authors.forename: J W
authors.initials: JW
authors.lastname: Strohbach
mesh_terms: D019281:Dimerization; D015195:Drug Design; D016333:HIV Protease / Q000378:metabolism; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015497:HIV-1 / Q000201:enzymology; D007202:Indicators and Reagents; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D011753:Pyrones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D017320:HIV Protease Inhibitors; D007202:Indicators and Reagents; D011753:Pyrones; D013449:Sulfonamides; D016333:HIV Protease