title: Modulation of plasma metalloproteinase-9 concentrations and peripheral blood monocyte mRNA levels in patients with septic shock: effect of fiber-immobilized polymyxin B treatment.
abstract: The authors measured plasma metalloproteinase (MMP)-9 and corresponding monocyte mRNA in 20 patients with septic shock. Plasma MMP-9 concentrations and monocyte MMP-9 mRNA levels were significantly higher in the 10 nonsurviving patients with septic shock than in 10 surviving patients and 25 normal controls. Hemoperfusion using polymyxin B immobilized on fibers (PMX-F), a reportedly effective treatment for septic shock, was studied for effects on MMP-9 in the patients. Increases in plasma MMP-9 concentrations and corresponding monocyte mRNA levels were attenuated significantly by PMX-F treatment in both nonsurviving and surviving patients. These data suggest that plasma MMP-9 concentrations and monocyte MMP-9 mRNA levels may be useful prognostic markers in septic shock, and that PMX-F treatment affects MMP-9.
authors.affiliation: Department of Medicine, Misato Junshin Hospital, Saitama, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: I
authors.initials: I
authors.lastname: Ebihara
authors.forename: N
authors.initials: N
authors.lastname: Shimada
authors.forename: H
authors.initials: H
authors.lastname: Shoji
authors.forename: H
authors.initials: H
authors.lastname: Koide
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D017364:Collagenases / Q000097:blood* / Q000187:drug effects / Q000235:genetics; D006464:Hemoperfusion; D006801:Humans; D020780:Matrix Metalloproteinase 9; D008875:Middle Aged; D009000:Monocytes / Q000187:drug effects / Q000201:enzymology*; D011112:Polymyxin B / Q000627:therapeutic use*; D011379:Prognosis; D012333:RNA, Messenger / Q000097:blood* / Q000187:drug effects; D012772:Shock, Septic / Q000097:blood* / Q000188:drug therapy* / Q000201:enzymology / Q000235:genetics; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D015415:Biomarkers; D012333:RNA, Messenger; D017364:Collagenases; D020780:Matrix Metalloproteinase 9; D011112:Polymyxin B