Synthesis and evaluation of paclitaxel C7 derivatives: solution phase synthesis of combinatorial libraries.
A novel and efficient two-step, automated solution phase synthesis of a 26-membered combinatorial chemistry library of paclitaxel C7 esters was accomplished using the HP 7686 Solution Phase Synthesizer. Results of combinatorial synthesis, purification, analysis, and biological evaluation are described.
Bhat
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L
Department of Medicinal Chemistry, Higuchi Bioscience Center, University of Kansas, Lawrence 66045, USA.
Liu
Y
Y
Victory
S F
SF
Himes
R H
RH
Georg
G I
GI
D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D017239:Paclitaxel / Q000031:analogs & derivatives* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel