title: Biology and genetics of malignant brain tumours.
abstract: Conventional therapies such as surgery, radiotherapy and, to a lesser extent, chemotherapy have produced significant increases in survival in patients with some types of brain tumours such as medulloblastoma. However, in many other types of brain tumour in both adults and children, the effect of these modalities has been more modest. A thorough understanding of the biology of malignant brain tumours is likely to provide the background for the development of new leads that might be amenable to therapeutic exploitation. This review examines some aspects of glioma biology that have been reported in the past 12 months, and which might be translated into clinical application.
authors.affiliation: University Department of Neurosurgery, Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, UK.
authors.forename: J L
authors.initials: JL
authors.lastname: Darling
authors.forename: T J
authors.initials: TJ
authors.lastname: Warr
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics; D000328:Adult; D001254:Astrocytoma / Q000235:genetics / Q000628:therapy; D001932:Brain Neoplasms / Q000235:genetics* / Q000628:therapy; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002528:Cerebellar Neoplasms / Q000235:genetics / Q000628:therapy; D002648:Child; D004252:DNA Mutational Analysis; D004806:Ependymoma / Q000235:genetics / Q000628:therapy; D006801:Humans; D008527:Medulloblastoma / Q000235:genetics / Q000628:therapy; D009837:Oligodendroglioma / Q000235:genetics / Q000628:therapy; D011379:Prognosis
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1