title: Heparin in acute ischaemic stroke. The T wave is negative and it's time to stop.
abstract: The use of heparin for acute ischaemic stroke has long been controversial. Although it may have some theoretical benefits in preventing fibrin formation and thrombus propagation, data from 16 randomised controlled trials involving more than 22,000 patients show that heparin produces no significant net benefit in eventual outcome.
authors.affiliation: Stroke Unit, Royal Perth Hospital, WA. gjhankey@cyllene.uwa.edu.au
authors.forename: G J
authors.initials: GJ
authors.lastname: Hankey
mesh_terms: D000208:Acute Disease; D001291:Attitude of Health Personnel; D002545:Brain Ischemia / Q000188:drug therapy*; D004569:Electroencephalography; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D055502:Secondary Prevention; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D006493:Heparin