[Effects of glutamate and ATP on interleukin 6 production by cultured neonatal rat astrocyte].
The effects of glutamate (Glu) and ATP on interleukin-6 (IL-6) production from cultured neonatal rat astrocyte were studied. Glu (100-200 mumol.L-1) strongly increased, IL-6 production at 16 h in a dose-dependent manner and ATP (50-100 mumol.L-1) induced a inhibition effect. The results suggest that Glu stimulted IL-6 release may be one of mechanisms of astrocyte "neuroprotective" function in ischmia/reperfusion.
Wu
L
L
Department of Physiology, Hunan Medical University, Changsha.
Cao
Z
Z
Zhu
X
X
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D001253:Astrocytes / Q000166:cytology / Q000378:metabolism*; D001921:Brain / Q000166:cytology*; D002478:Cells, Cultured; D003470:Culture Media; D018698:Glutamic Acid / Q000494:pharmacology*; D015850:Interleukin-6 / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar
D003470:Culture Media; D015850:Interleukin-6; D018698:Glutamic Acid; D000255:Adenosine Triphosphate