Design and synthesis of SH3 domain binding ligands: modifications of the consensus sequence XPpXP.
Spirolactam-based Pro-Pro mimetics incorporated in the consensus sequence XPpXP, lead to effective nonpeptide ligands of SH3 domains.
Witter
D J
DJ
Cadus Pharmaceutical Corporation, Tarrytown, NY 10591, USA.
Famiglietti
S J
SJ
Cambier
J C
JC
Castelhano
A L
AL
D001665:Binding Sites; D015195:Drug Design; D008024:Ligands; D008968:Molecular Conformation; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000378:metabolism; D018909:src Homology Domains
D008024:Ligands; D009842:Oligopeptides