title: Structure based design: novel spirocyclic ethers as nonpeptidal P2-ligands for HIV protease inhibitors.
abstract: A series of novel spirocyclic ethers were designed to function as nonpeptidal P2-ligands for HIV-1 protease inhibitors. Incorporation of designed ligands in the (R)-(hydroxyethylamino)sulfonamide isostere afforded potent HIV protease inhibitors.
authors.affiliation: Department of Chemistry, University of Illinois at Chicago 60607, USA.
authors.forename: A K
authors.initials: AK
authors.lastname: Ghosh
authors.forename: K
authors.initials: K
authors.lastname: Krishnan
authors.forename: D E
authors.initials: DE
authors.lastname: Walters
authors.forename: W
authors.initials: W
authors.lastname: Cho
authors.forename: H
authors.initials: H
authors.lastname: Cho
authors.forename: Y
authors.initials: Y
authors.lastname: Koo
authors.forename: J
authors.initials: J
authors.lastname: Trevino
authors.forename: L
authors.initials: L
authors.lastname: Holland
authors.forename: J
authors.initials: J
authors.lastname: Buthod
mesh_terms: D018360:Crystallography, X-Ray; D015195:Drug Design; D004988:Ethers, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D016333:HIV Protease / Q000378:metabolism*; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D015497:HIV-1 / Q000201:enzymology; D006801:Humans; D007700:Kinetics; D008024:Ligands; D008958:Models, Molecular; D008968:Molecular Conformation; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D004988:Ethers, Cyclic; D017320:HIV Protease Inhibitors; D008024:Ligands; D016333:HIV Protease