Topographic distribution of Helicobacter pylori in the resected stomach.
OBJECTIVE
The aim of this study was to elucidate the prevalence of Helicobacter pylori and its distribution in order to clarify the frequency of H. pylori infection and the most appropriate site of endoscopic biopsy for studies of H. pylori infection associated with different gastric diseases.


METHODS
Swiss role mucosal strips from 275 resected stomachs, which included the greater curvature, anterior wall and lesser curvature of the antrum, incisura and corpus, were stained with haematoxylin-eosin and H. pylori antibody.


RESULTS
The prevalence of H. pylori infection was 97% in duodenal ulcers, 98% in gastric ulcers, 98% in intestinal-type carcinomas and 99% in diffuse-type carcinomas. H. pylori was present at a rate of 100% in any site in cases of duodenal ulcer, but was diffusely distributed in the antrum and patchily distributed in the corpus. The detection rate of H. pylori was 50-100% in gastric ulcers, 30-100% in intestinal-type adenocarcinomas and 63-100% in diffuse-type adenocarcinomas depending on the site of the stomach examined.


CONCLUSIONS
The prevalence of H. pylori infection was very high in peptic ulcers of the duodenum and stomach and gastric carcinomas of Japanese patients. Biopsy specimens for evaluation of H. pylori infection should be taken routinely from both the greater curvature of the antrum and corpus. Immunohistochemical staining should be used to assay for H. pylori when few organisms are present or eradication therapy has been used.
Enomoto
H
H
First Department of Pathology, Niigata University School of Medicine, Japan.
Watanabe
H
H
Nishikura
K
K
Umezawa
H
H
Asakura
H
H
D000230:Adenocarcinoma / Q000382:microbiology*; D004381:Duodenal Ulcer / Q000382:microbiology*; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D007150:Immunohistochemistry; D016612:Paraffin Embedding; D012189:Retrospective Studies; D013270:Stomach / Q000382:microbiology*; D013274:Stomach Neoplasms / Q000382:microbiology*; D013276:Stomach Ulcer / Q000382:microbiology*