title: Treatment of oral leukoplakia by topical application of 5-aminolevulinic acid.
abstract: A new therapy for the treatment of oral leukoplakia by 5-aminolevulinic acid (ALA) and photodynamic therapy (PDT) is presented. ALA, a precursor in the biosynthesis of haeme, induces the production of the endogenous photosensitizer protoporphyrin IX which can be used for PDT. Twelve patients, who had been suffering from leukoplakia of the oral mucosa for several years, were treated by ALA-mediated PDT. ALA was used as a topical photosensitizer and 20% ALA cream was applied to the leukoplakia lesion of the oral mucosa for two hours and then light activated at 630 nm, 100 mW/cm2 and 100 J/cm2. Five patients showed complete response to the treatment, four patients showed a partial response and in three patients treatment was unsuccessful. One patient with partial response was retreated, after which the lesion disappeared.
authors.affiliation: Department of Oral and Maxillofacial Surgery, University of Heidelberg, Germany. akuebler@ukl.uni-heidelberg.de
authors.forename: A
authors.initials: A
authors.lastname: Kübler
authors.forename: T
authors.initials: T
authors.lastname: Haase
authors.forename: M
authors.initials: M
authors.lastname: Rheinwald
authors.forename: T
authors.initials: T
authors.lastname: Barth
authors.forename: J
authors.initials: J
authors.lastname: Mühling
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000622:Aminolevulinic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D001128:Argon; D005260:Female; D006801:Humans; D053685:Laser Therapy; D007972:Leukoplakia, Oral / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D011524:Protoporphyrins / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D017319:Photosensitizing Agents; D011524:Protoporphyrins; D001128:Argon; D000622:Aminolevulinic Acid; C028025:protoporphyrin IX