title: [The role of the mast cells of the conjunctiva in the intercellular interactions in keratoconus and epithelial-endothelial corneal dystrophy].
abstract: The aim of this study was assessment of the role of mast cells in inflammatory processes associated with keratoconus and corneal epithelial-endothelial dystrophy and clinical assessment of Lecrolin, a specially designed dosage form (eye drops) of potassium cromoglycate (intal) used as an antiallergic drug in asthma, rhinitis, etc. Examinations of 43 biopsy specimens of the conjunctiva from patients with keratoconus and epithelial-endothelial corneal dystrophy demonstrated the significance of immune inflammation in the pathogenesis of these diseases. Mast cells are a typical cell element participating in inflammation at all stages. The count of mast cells increases from 2.5 during the acute stage to 8.86 during the chronic stage, which is explained by absence of the leukocytic stage and proteolysis and stabilization of mature labrocyte degranulation associated with it. Reactions of mast cells with lymphocytes and monocytes/macrophages lead to proliferation of fibroblasts and chronic development of collagen formation. Close relationships between microvessels and mast cells promote stable spasms of the vessels, impairing the microcirculatory bed and leading to ischemia of the anterior segment of the eye. In such cases sodium cromolyne drugs (lecrolin) inhibiting histamine release and stabilizing mast cell membranes are recommended.
authors.forename: G G
authors.initials: GG
authors.lastname: Ziangirova
authors.forename: O V
authors.initials: OV
authors.lastname: Antonova
authors.forename: A A
authors.initials: AA
authors.lastname: Kasparov
mesh_terms: D001706:Biopsy; D002450:Cell Communication; D003228:Conjunctiva / Q000098:blood supply / Q000648:ultrastructure*; D003317:Corneal Dystrophies, Hereditary / Q000188:drug therapy / Q000473:pathology*; D004205:Cromolyn Sodium / Q000008:administration & dosage; D004341:Drug Evaluation; D006801:Humans; D007640:Keratoconus / Q000188:drug therapy / Q000473:pathology*; D008407:Mast Cells / Q000648:ultrastructure*; D008833:Microcirculation / Q000648:ultrastructure; D008854:Microscopy, Electron; D009883:Ophthalmic Solutions
chemical_list: D009883:Ophthalmic Solutions; D004205:Cromolyn Sodium
vernacular_title: Rol' tuchnykh kletok kon''iunktivy glaza v mezhkletochnykh vzaimodeĭstviiakh pri keratokonuse i épitelial'no-éndotelial'noĭ distrofii rogovitsy.