title: Human Immunodeficiency Virus Reverse Transcriptase and Protease Sequence Database.
abstract: The HIV RT and Protease Sequence Database is an on-line relational database that catalogues evolutionary and drug-related human immunodeficiency virus reverse transcriptase (RT) and protease sequence variation (http://hivdb.stanford.edu). The database contains a compilation of nearly all published HIV RT and protease sequences including International Collaboration database submissions (e.g., GenBank) and sequences published in journal articles. Sequences are linked to data about the source of the sequence sample and the anti-HIV drug treatment history of the individual from whom the isolate was obtained. The database is curated and sequences are annotated with data from 180 literature references. Users can retrieve additional data and view alignments of sequences sets meeting specific criteria (e.g., treatment history, subtype, presence of a particular mutation).
authors.affiliation: Division of Infectious Diseases, Stanford University Medical Center, Stanford, CA 94305, USA. rshafer@cmgm.stanford.edu
authors.forename: R W
authors.initials: RW
authors.lastname: Shafer
authors.forename: D
authors.initials: D
authors.lastname: Stevenson
authors.forename: B
authors.initials: B
authors.lastname: Chan
mesh_terms: D019380:Anti-HIV Agents / Q000494:pharmacology / Q000627:therapeutic use; D016208:Databases, Factual / Q000639:trends; D004352:Drug Resistance, Microbial / Q000235:genetics; D004359:Drug Therapy, Combination; D019143:Evolution, Molecular; D005814:Genes, Viral / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D006678:HIV / Q000737:chemistry / Q000187:drug effects / Q000235:genetics; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology; D016333:HIV Protease / Q000737:chemistry / Q000235:genetics*; D054303:HIV Reverse Transcriptase / Q000737:chemistry / Q000235:genetics*; D006801:Humans; D016247:Information Storage and Retrieval; D020407:Internet; D009154:Mutation / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics; D016415:Sequence Alignment
chemical_list: D019380:Anti-HIV Agents; D054303:HIV Reverse Transcriptase; D016333:HIV Protease