Linoleic acid peroxidation--the dominant lipid peroxidation process in low density lipoprotein--and its relationship to chronic diseases.
Modern separation and identification methods enable detailed insight in lipid peroxidation (LPO) processes. The following deductions can be made: (1) Cell injury activates enzymes: lipoxygenases generate lipid hydroperoxides (LOOHs), proteases liberate Fe ions--these two processes are prerequisites to produce radicals. (2) Radicals attack any activated CH2-group of polyunsaturated fatty acids (PUFAs) with about a similar probability. Since linoleic acid (LA) is the most abundant PUFA in mammals, its LPO products dominate. (3) LOOHs are easily reduced in biological surroundings to corresponding hydroxy acids (LOHs). LOHs derived from LA, hydroxyoctadecadienoic acids (HODEs), surmount other markers of LPO. HODEs are of high physiological relevance. (4) In some diseases characterized by inflammation or cell injury HODEs are present in low density lipoproteins (LDL) at 10-100 higher concentration, compared to LDL from healthy individuals.
Spiteller
G
G
Lehrstuhl Organische Chemie I, Universität Bayreuth, Germany. gerhard.spiteller@uni-bayreuth.de
D000375:Aging / Q000378:metabolism; D000975:Antioxidants / Q000378:metabolism; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002908:Chronic Disease; D010450:Endopeptidases / Q000378:metabolism; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D019787:Linoleic Acid / Q000737:chemistry / Q000378:metabolism*; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000737:chemistry / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008084:Lipoxygenase / Q000378:metabolism; D008956:Models, Chemical
D000975:Antioxidants; D005609:Free Radicals; D008054:Lipid Peroxides; D008077:Lipoproteins, LDL; D019787:Linoleic Acid; D008084:Lipoxygenase; D010450:Endopeptidases