Expression of type I interferon receptor and its relation with other prognostic factors in human neuroblastoma.
Expression of type I interferon receptor (IFN-R) has been found in several normal tissues and in malignant neoplasms, mainly those with epithelial differentiation. In order to analyze the immunohistochemical expression of type I IFN-R we studied 79 cases of neuroblastoma. Results of expression of type I IFN-R were statistically correlated with histopathology, stage, bcl-2 and PCNA expression, N-myc amplification and apoptosis. We found expression of type I IFN-R in 54/79 cases showing statistical correlation with bcl-2 expression (P=0.017) and favourable histopathology (P=0.015). The overexpression found in ganglion cells suggests that IFN-R could be involved in the pathway of neuroblastoma differentiation. Moreover, the expression of type I IFN-R in stage 4 cases (12/20), even with N-myc amplification (6/8), opens new possibilities for therapeutic management in advanced cases that do not respond to any chemotherapeutic protocol.
Mejía
C
C
Department of Pathology, Medical School, University of Valencia, Valencia 46010, Spain.
Navarro
S
S
Colamonici
O R
OR
Pellín
A
A
Castel
V
V
Llombart-Bosch
A
A
D017209:Apoptosis; D014408:Biomarkers, Tumor / Q000032:analysis*; D002454:Cell Differentiation; D002648:Child; D002675:Child, Preschool; D005784:Gene Amplification; D016259:Genes, myc; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D008565:Membrane Proteins; D009363:Neoplasm Proteins / Q000032:analysis*; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000737:chemistry* / Q000235:genetics / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis; D053633:Receptor, Interferon alpha-beta; D017471:Receptors, Interferon / Q000032:analysis*; D013030:Spain / Q000453:epidemiology
D014408:Biomarkers, Tumor; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D018809:Proliferating Cell Nuclear Antigen; D019253:Proto-Oncogene Proteins c-bcl-2; D017471:Receptors, Interferon; D053633:Receptor, Interferon alpha-beta