title: N'-methylniphimycin, a novel minor congener of niphimycin from Streptomyces spec. 57-13.
abstract: A novel natural niphimycin analog, N'-methylniphimycin was isolated from the culture broth of the Streptomyces spec. 57-13. The chemical constitution was elucidated from the physico-chemical properties, NMR techniques and mass spectrometry to be a 36-membered macrolide related to azalomycin F5a, shurimycin B and RS-22C. N'-methylniphimycin displayed moderate activity against some yeasts and filamentous fungi.
authors.affiliation: Institute of Microbiology, Bulgarian Academy of Sciences, Acad. G. Bonchev, Sofia, Bulgaria.
authors.forename: V
authors.initials: V
authors.lastname: Ivanova
authors.forename: R
authors.initials: R
authors.lastname: Schlegel
authors.forename: K
authors.initials: K
authors.lastname: Dornberger
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D005658:Fungi / Q000187:drug effects; D006146:Guanidines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013058:Mass Spectrometry; D013302:Streptomyces / Q000737:chemistry* / Q000254:growth & development; D015003:Yeasts / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D006146:Guanidines; C116861:N'-methylniphimycin