title: Pacing mode and long-term survival in elderly patients with congestive heart failure: 1980-1985.
abstract: Dual-chamber pacing may improve short-term hemodynamics and functional class in some patients with congestive heart failure, even in the absence of conventional indications for pacemaker implantation. However, the impact of different pacing modes on survival of patients with congestive heart failure is controversial. In this retrospective study we analyzed survival data from 546 elderly patients, aged 70 years and older, who underwent implantation of a permanent dual-chamber (DDD, n = 62, DVI, n = 102) or single-chamber (VVI) pacemaker (n = 382) between 1980 and 1985. Survival was further analyzed according to the presence of absence of congestive heart failure, and pacemaker mode (DDD vs. DVI vs. VVI). Overall, dual-chamber pacing (DDD and DVI) was associated with a more favorable long-term outcome when compared with single-chamber ventricular pacing, although differences were only significant for DDD pacing (P = 0.002). When patients with and without preexisting congestive heart failure were analyzed separately, survival following dual-chamber pacing (DDD and DVI) was significantly better than survival following single-chamber pacing in patients without congestive heart failure (P = 0.03), but not in patients with preexisting heart failure (P = 0.139). When patients were analyzed according to the electrophysiological indication for pacemaker implantation, overall survival of patients with AV block (P = 0.0025) but not sinus node dysfunction (P = 0.346) was improved with dual-chamber pacing. This survival advantage in patients with AV block following dual-chamber pacing was lost in the presence of heart failure (P = 0.11). These findings suggest that dual-chamber pacing, in particular DDD pacing, improves the survival in elderly patients without preexisting congestive heart failure. In contrast to the short-term hemodynamic improvement observed in selected patients with congestive heart failure, dual-chamber pacing in elderly patients with congestive heart failure, paced for conventional indications, is not associated with improved survival when compared with single-chamber ventricular pacing.
authors.affiliation: Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Mayo Foundation, Rochester, Minnesota 55905, USA.
authors.forename: P A
authors.initials: PA
authors.lastname: Brady
authors.forename: W K
authors.initials: WK
authors.lastname: Shen
authors.forename: S A
authors.initials: SA
authors.lastname: Neubauer
authors.forename: S C
authors.initials: SC
authors.lastname: Hammill
authors.forename: D O
authors.initials: DO
authors.lastname: Hodge
authors.forename: D L
authors.initials: DL
authors.lastname: Hayes
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D002304:Cardiac Pacing, Artificial / Q000379:methods*; D005260:Female; D006327:Heart Block / Q000209:etiology / Q000601:surgery; D006333:Heart Failure / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D008297:Male; D010138:Pacemaker, Artificial; D012189:Retrospective Studies; D012849:Sinoatrial Node / Q000503:physiopathology; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome