Artificial endometrial preparation for oocyte donation using synthetic estrogen and progestogen.
OBJECTIVE
To evaluate the outcome of an oocyte donation program using synthetic estrogen and progestational agents for uterine preparation.


METHODS
Conjugated estrogen, 1.25 mg per day at increasing doses and dydrogesterone, a synthetic progestogen, 30 mg per day were used for uterine priming. All embryo transfers were done on day 2 of progestogen supplementation.


RESULTS
The pregnancy rates were 38% per embryo transfer. The ongoing pregnancy rate was 31% with an abortion rate of 20%.


CONCLUSIONS
Endometrial preparation in an oocyte donation program using orally administered synthetic estrogen and progestogen gives pregnancy rates comparable to those reported with natural products.
Abu-Musa
A
A
Department of Obstetrics and Gynecology, American University of Beirut-Medical Center, Lebanon.
Hannoun
A
A
Khalil
A
A
Masaad
Z
Z
Karam
K
K
D000328:Adult; D002064:Buserelin / Q000008:administration & dosage; D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D004394:Dydrogesterone / Q000008:administration & dosage*; D004624:Embryo Transfer; D004717:Endometrium / Q000502:physiology*; D004958:Estradiol / Q000097:blood; D004966:Estrogens, Conjugated (USP) / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008593:Menopause; D008596:Menotropins / Q000008:administration & dosage; D018587:Oocyte Donation; D006080:Ovarian Follicle / Q000000981:diagnostic imaging; D011247:Pregnancy; D016649:Primary Ovarian Insufficiency; D045167:Progesterone Congeners; D014463:Ultrasonography
D006063:Chorionic Gonadotropin; D004966:Estrogens, Conjugated (USP); D045167:Progesterone Congeners; D004958:Estradiol; D008596:Menotropins; D004394:Dydrogesterone; D002064:Buserelin