Response of chickens carrying germline insert ALVA11 to challenge with a field strain of subgroup A avian leukosis virus.
The ALVA11 germline insert in chickens is a defective subgroup A avian leukosis virus (ALV) proviral insert that expresses a low-to-moderate level of subgroup A ALV envelope glycoprotein. Chicks carrying or lacking ALVA11 were evaluated for response to challenge by RPL-42, a pathogenic field strain of subgroup A ALV, by either exposure to chicks shedding RPL-42 or direct injection with various doses of RPL-42. Chicks carrying ALVA11 were significantly more resistant, as measured by infectious virus and viral antibody status, to horizontal infection and direct injection of RPL-42 than chicks lacking ALVA11.
Salter
D W
DW
Department of Microbiology, Michigan State University, East Lansing 48824, USA.
Payne
W
W
Crittenden
L B
LB
Fadly
A M
AM
D000818:Animals; D030801:Animals, Genetically Modified; D001353:Avian Leukosis / Q000235:genetics* / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D001354:Avian Leukosis Virus / Q000235:genetics* / Q000302:isolation & purification; D002645:Chickens; D003433:Crosses, Genetic; D005260:Female; D018095:Germ-Line Mutation; D006579:Heterozygote; D008297:Male; D016254:Mutagenesis, Insertional; D014759:Viral Envelope Proteins / Q000235:genetics; D017201:Virus Shedding
D014759:Viral Envelope Proteins