Synthesis and biological evaluation of two analogues of (S)-alpha-methyl-3-carboxyphenylalanine.
Two analogues 2, 3 of (S)-alpha-methyl-3-carboxylphenylalanine 1 were synthesized to test their activity for metabotropic glutamate receptors (mGluRs). Both compounds 2 and 3 were inactive as antagonist for mGluRs, but 2 showed weak agonistic activity for GluR6 in contrast to that reported by Kemp and co-workers.
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State Key Laboratory of Bio-organic and Natural Product Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China.
Ma
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Kozikowski
A P
AP
Pshenichkin
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S
Wroblewski
J T
JT
D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D008956:Models, Chemical; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000737:chemistry; D018092:Kainic Acid Receptors / Q000819:agonists; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors*; D000097806:GluK2 Kainate Receptor
D010649:Phenylalanine; D018092:Kainic Acid Receptors; D018094:Receptors, Metabotropic Glutamate; D000097806:GluK2 Kainate Receptor; C103199:alpha-methyl-3-carboxyphenylalanine