title: Metastatic RCC arising in a transplant kidney.
abstract: We report a case of metastatic renal cell carcinoma arising in a cadaver transplant kidney 6 years after transplantation. Due to molecular analysis of the tumor tissue we could prove that the carcinoma originated from the male donor. After tumor resection and interruption of immunotherapy, the concomitant bone and lymph node metastases resolved with alpha-interferon and interleukin-2-based immunotherapy.
authors.affiliation: Department of Diagnostic Radiology, Justus Liebig University Giessen, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Kunisch-Hoppe
authors.forename: M
authors.initials: M
authors.lastname: Hoppe
authors.forename: R M
authors.initials: RM
authors.lastname: Bohle
authors.forename: K
authors.initials: K
authors.lastname: Rauber
authors.forename: B
authors.initials: B
authors.lastname: Weimar
authors.forename: S
authors.initials: S
authors.lastname: Friemann
authors.forename: U
authors.initials: U
authors.lastname: Stahl
authors.forename: W S
authors.initials: WS
authors.lastname: Rau
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D002292:Carcinoma, Renal Cell / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use; D007376:Interleukin-2 / Q000627:therapeutic use; D007680:Kidney Neoplasms / Q000209:etiology* / Q000473:pathology* / Q000628:therapy; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000473:pathology; D008159:Lumbar Vertebrae; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011859:Radiography; D006435:Renal Dialysis; D012730:Sex Chromosomes / Q000235:genetics; D013125:Spinal Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy; D014019:Tissue Donors
chemical_list: D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D016898:Interferon-alpha; D007376:Interleukin-2