A mutant of Mycobacterium smegmatis defective in dipeptide transport.
A mutant of Mycobacterium smegmatis unable to use the dipeptide carnosine (beta-alanyl-L-histidine) as a sole carbon or nitrogen source was isolated. Carnosinase activity and the ability to grow on beta-Ala and/or L-His were similar in the mutant and the wild type. However, the mutant showed significant impairment in the uptake of carnosine. This study is the first description of a peptide utilization mutant of a mycobacterium.
Bhatt
A
A
Department of Microbiology and Molecular Genetics, and Department of Surgery, UMDNJ/New Jersey Medical School, Newark, New Jersey 07103, USA.
Green
R
R
Coles
R
R
Condon
M
M
Connell
N D
ND
D001692:Biological Transport; D002336:Carnosine / Q000378:metabolism; D004151:Dipeptides / Q000378:metabolism*; D009154:Mutation; D020102:Mycobacterium smegmatis / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*
D004151:Dipeptides; D002336:Carnosine