Gingival fluid IL-1beta in postmenopausal females on supportive periodontal therapy. A longitudinal 2-year study.
Posterior interproximal alveolar bone in 59 women, within 5 years after menopause, was assessed at baseline and after 2 years of supportive periodontal therapy (history of moderate/advanced periodontitis) using digitized image analysis. Baseline lumbar spine bone mineral density, smoking status, and yearly serum estradiol (E2) levels also were obtained to group subjects. An additional 16 non-periodontitis postmenopausal women were followed 2 years for clinical and estrogen status. 2-min GCF IL-1beta levels averaged from 2 baseline periodontal pockets (in periodontitis subjects) and 2 non-periodontitis sites (in non-periodontitis and periodontitis subjects) were determined with an enzyme immunoassay. A progressive and stable site were also monitored every 6 months for GCF IL-1beta in 15 patients. Results after 2 years indicated that 17 subjects had no posterior interproximal sites losing > or =0.4 mm of alveolar crest bone height, while 13 subjects had > or =3 such sites. Using analysis of variance, none of the above clinical groupings resulted in a significant difference in mean baseline or longitudinal GCF IL-1beta levels. However, when subjects who lost alveolar crest bone height were considered, E2-sufficient subjects had significantly depressed baseline GCF IL-1beta (in past-periodontitis sites) compared to E2-deficient patients (9.1+/-2.1 versus 31.7+/-10.2 pg/2-min sample, p<0.05), suggesting E2 influences gingival IL-1beta production in progressive periodontitis patients.
Reinhardt
R A
RA
Department of Surgical Specialities, University of Nebraska Medical Center College of Dentistry, Lincoln 68583-0757, USA.
Payne
J B
JB
Maze
C
C
Babbitt
M
M
Nummikoski
P V
PV
Dunning
D
D
D015502:Absorptiometry, Photon; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000378:metabolism*; D000704:Analysis of Variance; D015519:Bone Density; D003777:Dental Prophylaxis; D018450:Disease Progression; D004958:Estradiol / Q000097:blood / Q000172:deficiency / Q000502:physiology; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry*; D006801:Humans; D007124:Immunoenzyme Techniques; D007375:Interleukin-1 / Q000032:analysis* / Q000096:biosynthesis; D008137:Longitudinal Studies; D008875:Middle Aged; D010518:Periodontitis / Q000503:physiopathology* / Q000628:therapy; D017698:Postmenopause / Q000502:physiology*; D013131:Spine / Q000000981:diagnostic imaging
D007375:Interleukin-1; D004958:Estradiol