Design and synthesis of analogs of vitamin E: antiproliferative activity against human breast adenocarcinoma cells.
Analogs of alpha-tocopherol (vitamin E; compounds 3-9) have been synthesized and tested for their antiproliferative activity using the human breast cancer cell line, MCF7. Compounds 6-9 were synthesized from a common symthom, rac-Trolox (14) and are soluble/miscible at physiological pH. Compounds 4, 8, and 9 were found to have antiproliferative activity at micromolar concentrations.
Arya
P
P
Steacie Institute for Molecular Sciences, National Research Council of Canada, Ottawa, Ontario.
Alibhai
N
N
Qin
H
H
Burton
G W
GW
Batist
G
G
You
S X
SX
Alaoui-Jamali
M A
MA
D000230:Adenocarcinoma / Q000473:pathology*; D001943:Breast Neoplasms / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects; D015195:Drug Design; D005260:Female; D006801:Humans; D008956:Models, Chemical; D014407:Tumor Cells, Cultured; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000494:pharmacology
D014810:Vitamin E