[Effects of inhibitor of protein kinase C on brain edema formation evoked by experimental cerebral ischemia in gerbils and rats].
Recent studies have suggested that protein kinase C (PKC) may be involved in the formation of brain edema. In this paper, the effects of two kinds of PKC inhibitors, H-7 and matrine, were examined on the brain edema formation in experimental models. The results showed that pretreatment with H-7 6.25 and 12.5 mg.kg-1 prevented the accumulation of water and certain electrolytes in the unilateral hemisphere of the brain evoked by ligation of a single common carotid artery in Mongolian gerbil; pretreatment with matrine 25 and 50 mg.kg-1 reduced the extent of cerebral edema formation evoked by ligation of a single common carotid artery in gerbil and by middle cerebral artery occlusion in Sprague-Dawley rats. These results present new evidence for the involvement of PKC in the formation of brain edema.
Hu
Z L
ZL
Research Laboratory of Natural and Synthetic Drugs, College of Pharmacy, Second Military Medical University, Shanghai.
Tan
Y X
YX
Zhang
J P
JP
Qian
D H
DH
D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine / Q000627:therapeutic use*; D000470:Alkaloids / Q000627:therapeutic use*; D000818:Animals; D001929:Brain Edema / Q000209:etiology / Q000517:prevention & control*; D002545:Brain Ischemia / Q000150:complications*; D005849:Gerbillinae; D008297:Male; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*; D011807:Quinolizines; D051381:Rats; D017207:Rats, Sprague-Dawley; D000093842:Matrines
D000470:Alkaloids; D011807:Quinolizines; D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; D011493:Protein Kinase C; D000093842:Matrines