title: Sulfonamide derivatives of benzylamine block cholesterol biosynthesis in HepG2 cells: a new type of potent squalene epoxidase inhibitors.
abstract: Sulfonamide derivatives of ene-yne benzylamine 1 have been prepared and identified as a new class of potent SE inhibitors having demonstrated activity in HepG2 cells as cholesterol biosynthesis inhibitors.
authors.affiliation: Medicinal Chemistry Division, Centre de Recherche Pierre Fabre, Castres, France. cm4.crpf@pierre-fabre.imaginet.fr
authors.forename: J P
authors.initials: JP
authors.lastname: Gotteland
authors.forename: C
authors.initials: C
authors.lastname: Loubat
authors.forename: B
authors.initials: B
authors.lastname: Planty
authors.forename: D
authors.initials: D
authors.lastname: Junquéro
authors.forename: A
authors.initials: A
authors.lastname: Delhon
authors.forename: S
authors.initials: S
authors.lastname: Halazy
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001596:Benzylamines / Q000138:chemical synthesis* / Q000494:pharmacology; D002460:Cell Line; D002784:Cholesterol / Q000096:biosynthesis*; D004285:Dogs; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D008099:Liver / Q000201:enzymology; D010105:Oxygenases / Q000037:antagonists & inhibitors*; D051381:Rats; D050603:Squalene Monooxygenase; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology; D013552:Swine
chemical_list: D000924:Anticholesteremic Agents; D001596:Benzylamines; D004791:Enzyme Inhibitors; D013449:Sulfonamides; D002784:Cholesterol; D010105:Oxygenases; D050603:Squalene Monooxygenase