[Effect of carbon dioxide on free radical processes as affected by artificial hypobiosis in rats].
High CO2 concentrations in the inspired air have been studied for their effect on the free-radical oxidation of lipids in the lipids in the blood, its serum and mitochondria of the rat liver under artificial hypobiosis. Kinetics of free-radical oxidation of lipids was estimated from the changes in chemiluminescence parameters as well as the content of products which react with thiobarbituric acid. It is found that in animals in the state of artificial hypobiosis the intensity of free-radical oxidation of lipids was rather less as compared with animals which did not fall into hypobiosis because of the exclusion of CO2 from the inspired air. The data obtained permit concluding that the increase of CO2 concentration in the inspired air prevents from the development of the oxidative stress. It is evident that the increase of CO2 in the inspired air occurs before the formation of the adaptational mechanisms, directed to the preventing of lesion of membrane lipids under artificial hypobiosis.
Mel'nychuk
S D
SD
A.V. Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv.
Kuz'menko
A I
AI
Margitich
V M
VM
Govseeva
N N
NN
Gorid'ko
T N
TN
Hulaia
N M
NM
D000222:Adaptation, Physiological; D000818:Animals; D001833:Body Temperature Regulation / Q000502:physiology*; D002245:Carbon Dioxide / Q000378:metabolism / Q000494:pharmacology*; D005609:Free Radicals; D007700:Kinetics; D015227:Lipid Peroxidation / Q000502:physiology*; D008163:Luminescent Measurements; D008297:Male; D008928:Mitochondria / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology; D010100:Oxygen / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D005609:Free Radicals; D002245:Carbon Dioxide; D010100:Oxygen
Vliianie uglekisloty na svobodnoradikal'nye protsessy v usloviiakh iskusstvennogo gipobioza u krys.