Assignment of Ptprn2, the gene encoding receptor-type protein tyrosine phosphatase IA-2beta, a major autoantigen in insulin-dependent diabetes mellitus, to mouse chromosome region 12F.
The receptor-type protein tyrosine phosphatase IA-2beta gene (mouse gene symbol Ptprn2) encodes a major autoantigen in insulin-dependent diabetes mellitus. We physically mapped Ptprn2 by fluorescence in situ hybridization to band F of mouse chromosome 12, a region that lacks diabetes susceptibility loci. The mapping confirms the proposed synteny of mouse 12F with band q36 of human chromosome 7.
van den Maagdenberg
A M
AM
Cell Biology and Histology, Institute of Cellular Signalling, University of Nijmegen, Nijmegen (The Netherlands).
Schepens
J T
JT
Schepens
M T
MT
Pepers
B
B
Wieringa
B
B
van Kessel
A G
AG
Hendriks
W J
WJ
D000818:Animals; D001324:Autoantigens / Q000235:genetics*; D002874:Chromosome Mapping; D018076:DNA, Complementary; D003922:Diabetes Mellitus, Type 1 / Q000201:enzymology* / Q000235:genetics / Q000276:immunology; D017404:In Situ Hybridization, Fluorescence; D051379:Mice; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017027:Protein Tyrosine Phosphatases / Q000235:genetics* / Q000276:immunology
D001324:Autoantigens; D018076:DNA, Complementary; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017027:Protein Tyrosine Phosphatases