title: Primary cardiac lymphoma in an immunocompetent woman.
abstract: We report a fatal primary cardiac non-Hodgkin's lymphoma in a 62 years old immunocompetent woman presenting with tamponade and complete atrioventricular block. CT-scan, echocardiography and autopsy examination showed a tumor largely infiltrating the heart without extracardiac involvement. A surgical biopsy revealed high grade B-cell non-Hodgkin's lymphoma with a misleading myelomonocytic CD68 (KPI) expression. Polymerase Chain Reaction analysis revealed a clonal rearrangement of the immunoglobulin heavy chain gene and confirmed the B-cell origin of the lymphoma. Our report also emphasizes the role of immunohistochemical and molecular techniques in the diagnosis.
authors.affiliation: Department of Pathology, Hôpital du Haut-Lévêque, Bordeaux, France.
authors.forename: H
authors.initials: H
authors.lastname: Begueret
authors.forename: E
authors.initials: E
authors.lastname: Labouyrie
authors.forename: P
authors.initials: P
authors.lastname: Dubus
authors.forename: S
authors.initials: S
authors.lastname: Sempe
authors.forename: J F
authors.initials: JF
authors.lastname: Goussot
authors.forename: P
authors.initials: P
authors.lastname: Besse
authors.forename: A
authors.initials: A
authors.lastname: De Mascarel
authors.forename: J P
authors.initials: JP
authors.lastname: Merlio
mesh_terms: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D005260:Female; D006327:Heart Block / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D006338:Heart Neoplasms / Q000150:complications / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000150:complications / Q000473:pathology* / Q000503:physiopathology*; D008875:Middle Aged; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; C067980:CD68 antigen, human; D000097382:CD68 Molecule