title: HHV-8 is not associated with follicular dendritic cell tumours.
abstract: Follicular dendritic cell tumours are rare malignancies derived from the follicular dendritic cells of lymphoid follicles. These tumours have been associated with Epstein-Barr virus infections and with the hyaline vascular subtype of Castleman's disease. Because many examples of Castleman's disease have been associated with Kaposi's sarcoma associated herpes virus (HHV-8), this study uses polymerase chain reaction technology to examine five cases of follicular dendritic cell tumours for HHV-8. One of these cases had previously been documented to arise from pre-existing Castleman's disease. HHV-8 DNA was not detected in any of the follicular dendritic cell tumours examined, or in the original case of Castleman's disease. These findings suggest that HHV-8 plays no role in the aetiology of follicular dendritic cell tumours and the cause of this tumour remains obscure.
authors.affiliation: Department of Anatomical Pathology, School of Pathology, South African Institute for Medical Research, Johannesburg, South Africa.
authors.forename: S J
authors.initials: SJ
authors.lastname: Nayler
authors.forename: L
authors.initials: L
authors.lastname: Taylor
authors.forename: K
authors.initials: K
authors.lastname: Cooper
mesh_terms: D000293:Adolescent; D000328:Adult; D005871:Castleman Disease / Q000821:virology; D004279:DNA, Viral / Q000032:analysis; D004587:Electrophoresis, Agar Gel; D005260:Female; D006258:Head and Neck Neoplasms / Q000821:virology*; D019288:Herpesvirus 8, Human / Q000302:isolation & purification*; D006801:Humans; D008224:Lymphoma, Follicular / Q000821:virology*; D008297:Male; D016133:Polymerase Chain Reaction; D011230:Precancerous Conditions / Q000821:virology
chemical_list: D004279:DNA, Viral