title: Design and synthesis of a tetrahydropyran-based inhibitor of mammalian ribonucleotide reductase.
abstract: A tetrahydropyran-based inhibitor (2) of mammalian ribonucleotide reductase (mRR) has been designed and synthesized based on the heptapeptide, N-AcFTLDADF (1), corresponding to the C-terminus of the R2 subunit of mRR. Inhibition studies revealed that 2 is indeed a competent inhibitor, albeit less potent than 1.
authors.affiliation: Department of Chemistry, University of Pennsylvania, Philadelphia 19104, USA.
authors.forename: A B
authors.initials: AB
authors.lastname: Smith
authors.forename: S
authors.initials: S
authors.lastname: Sasho
authors.forename: B A
authors.initials: BA
authors.lastname: Barwis
authors.forename: P
authors.initials: P
authors.lastname: Sprengeler
authors.forename: J
authors.initials: J
authors.lastname: Barbosa
authors.forename: R
authors.initials: R
authors.lastname: Hirschmann
authors.forename: B S
authors.initials: BS
authors.lastname: Cooperman
mesh_terms: D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D008958:Models, Molecular; D011714:Pyrans / Q000138:chemical synthesis* / Q000494:pharmacology; D012264:Ribonucleotide Reductases / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D011714:Pyrans; D012264:Ribonucleotide Reductases