[Effects of composite blood-activating decoction on adhesive function of bone marrow stroma cells in radiation injured mice].
OBJECTIVE
To evaluate the effect of commonly used "blood activating and stasis-removing" Chinese herbal drugs on adhesive function of bone marrow stroma cells in acute radiation injured mice.


METHODS
After irradiation by 8 Gy 60Co gamma-ray, each mouse was intraperitoneally injected immediately with 0.2 ml 100% composite blood-activating decoction (CBAD) twice a day for 6 days. On the 7th day, the femura were taken and the bone karyocyte (BMC) suspension was made. According to long term bone marrow culture procedure, on the 12th day, the fibroblastic colony forming units were counted, and on the 28th day, the adhesion of culture stroma cells to normal murine BMC was observed.


RESULTS
The adhesion of culture stroma cells to normal murine BMC was 67.8 +/- 17.2% in normal group, while in CBAD group, it was 55.8 +/- 10.5%. The difference was insignificant (P > 0.05). In the control group, the value was 47.7 +/- 13.6%, which was significantly lower than that in normal group (P < 0.02).


CONCLUSIONS
The commonly used "blood-activating and stasis-removing" Chinese herbal drugs can enhance the adhesive function of bone marrow stroma cells in acute radiation injured mice.
Liu
W L
WL
Tongji Hospital, Tongji Medical University, Wuhan.
Huang
W
W
He
M
M
D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects*; D002448:Cell Adhesion / Q000187:drug effects; D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000473:pathology*; D017154:Stromal Cells / Q000187:drug effects; D014916:Whole-Body Irradiation
D004365:Drugs, Chinese Herbal