title: [Diagnostic and prognostic significance of biochemical indicators in colorectal neoplasms].
abstract: Activities of some enzymes and content of medium-weight molecules in patients with colorectal cancer were studied in order to assess the diagnostic value of these parameters for detection of tumors in the large intestine and development of endogenous intoxication after surgery and for prediction of remote results of treatment. Increased activities of creatine phosphokinase and hexokinase is typical of tumor growth, whereas increased activities of alkaline phosphatase and gamma-glutamyl transpeptidase are observed only in metastases to the liver. The role of medium-weight molecules in the diagnosis of endogenous intoxication during the early postoperative period is shown. The content of these molecules in the sera increases 3 days before clinical manifestation of endotoxicosis, when the traditional parameters are virtually normal.
authors.forename: A S
authors.initials: AS
authors.lastname: Agabalian
authors.forename: A P
authors.initials: AP
authors.lastname: Makarian
authors.forename: A M
authors.initials: AM
authors.lastname: Agavelian
authors.forename: A S
authors.initials: AS
authors.lastname: Akopian
mesh_terms: D000230:Adenocarcinoma / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology; D014408:Biomarkers, Tumor; D015179:Colorectal Neoplasms / Q000097:blood / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology; D003402:Creatine Kinase / Q000097:blood*; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D009362:Neoplasm Metastasis; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D007527:Isoenzymes; D003402:Creatine Kinase
vernacular_title: Diagnosticheskoe i prognasticheskoe znachenie riada biochimicheskikh pokazateleĭ pri kolorektal'nom rake.