title: Two novel oleanolic acid saponins having a sialyl Lewis X mimetic structure from Achyranthes fauriei root.
abstract: Two novel triterpene glycosides, achyranthosides E and F, were isolated as methyl esters from the root of Achyranthes fauriei, an antiinflammatory medicinal plant. Their structures were characterized as oleanolic acid glucuronides having unique substituents composed of C6H9O5 and C9H15O7, respectively, at the C-3 position of glucuronic acid. These compounds are active components which can inhibit the excess recruiting of neutrophiles to injured tissues 1,000 times more potently than sialyl Lewis X.
authors.affiliation: School of Pharamaceutical Sciences, Showa University, Tokyo, Japan. ida@pharm.showa-u.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Ida
authors.forename: Y
authors.initials: Y
authors.lastname: Satoh
authors.forename: M
authors.initials: M
authors.lastname: Katsumata
authors.forename: M
authors.initials: M
authors.lastname: Nagasao
authors.forename: Y
authors.initials: Y
authors.lastname: Hirai
authors.forename: T
authors.initials: T
authors.lastname: Kajimoto
authors.forename: N
authors.initials: N
authors.lastname: Katada
authors.forename: M
authors.initials: M
authors.lastname: Yasuda
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
mesh_terms: D009682:Magnetic Resonance Spectroscopy; D018716:Molecular Mimicry; D009828:Oleanolic Acid / Q000737:chemistry*; D009844:Oligosaccharides / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D000080506:Sialyl Lewis X Antigen; D016339:Spectrometry, Mass, Fast Atom Bombardment
chemical_list: D009844:Oligosaccharides; D000080506:Sialyl Lewis X Antigen; D009828:Oleanolic Acid