title: Modifications of the 4,4'-residues and SAR studies of Biphalin, a highly potent opioid receptor active peptide.
abstract: Modifications of 4,4' residues of Biphalin have resulted in greater binding selectivity and biological potency for the mu opioid receptor. A higher partition coefficient across the phospholipid bilayer membrane has been achieved by using a beta-branched unusual amino acids.
authors.affiliation: Department of Chemistry, University of Arizona, Tucson 85721, USA.
authors.forename: G
authors.initials: G
authors.lastname: Li
authors.forename: W
authors.initials: W
authors.lastname: Haq
authors.forename: L
authors.initials: L
authors.lastname: Xiang
authors.forename: B S
authors.initials: BS
authors.lastname: Lou
authors.forename: R
authors.initials: R
authors.lastname: Hughes
authors.forename: I A
authors.initials: IA
authors.lastname: De Leon
authors.forename: P
authors.initials: P
authors.lastname: Davis
authors.forename: T J
authors.initials: TJ
authors.lastname: Gillespie
authors.forename: M
authors.initials: M
authors.lastname: Romanowski
authors.forename: X
authors.initials: X
authors.lastname: Zhu
authors.forename: A
authors.initials: A
authors.lastname: Misicka
authors.forename: A W
authors.initials: AW
authors.lastname: Lipkowski
authors.forename: F
authors.initials: F
authors.lastname: Porreca
authors.forename: T P
authors.initials: TP
authors.lastname: Davis
authors.forename: H I
authors.initials: HI
authors.lastname: Yamamura
authors.forename: D F
authors.initials: DF
authors.lastname: O'Brien
authors.forename: V J
authors.initials: VJ
authors.lastname: Hruby
mesh_terms: D000700:Analgesics / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D004745:Enkephalins / Q000737:chemistry* / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008051:Lipid Bilayers; D017450:Receptors, Opioid, mu / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013816:Thermodynamics
chemical_list: D000700:Analgesics; D004745:Enkephalins; D008051:Lipid Bilayers; D017450:Receptors, Opioid, mu; C053673:biphalin