title: A comparative study of the beta-adrenoceptors in higher visual centres of birds.
abstract: This report describes the distribution of beta-adrenergic receptors in the telencephalic visual nuclei of chick, duck, pigeon, parakeet and goldfinch using [3H]CGP 12177 (4-3-t-butylamino-2-hydroxypropoxy-[5,7(3)H] benzimidazol-2-one) as a radioligand. The results reveal a predominance of the beta2-adrenoceptor subtype in all the species studied and that this subtype fits the pharmacological profile described for mammals. It is also demonstrated that the autoradiographic interspecific differences described in previous studies are due to changes in Bmax, while KD values remain in a similar range (0.1-0.6 nM). The distribution of beta-adrenoceptors was fairly similar in the areas of the visual Wulst of all five species studied while striking differences were found in the ectostriatum, the higher centre of the tectofugal pathway. Our findings support a role for ectostriatal beta-adrenoceptors in the visual adaptation and evolution of birds.
authors.affiliation: Departamento de Biología Celular, Facultad de Biología, Universidad de León, Spain.
authors.forename: V
authors.initials: V
authors.lastname: Revilla
authors.forename: R
authors.initials: R
authors.lastname: Revilla
authors.forename: A
authors.initials: A
authors.lastname: Fernández-López
mesh_terms: D000318:Adrenergic beta-Agonists / Q000378:metabolism; D000319:Adrenergic beta-Antagonists / Q000378:metabolism; D000818:Animals; D001345:Autoradiography; D001717:Birds / Q000378:metabolism*; D008297:Male; D011412:Propanolamines / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D014316:Tritium; D014795:Visual Pathways / Q000378:metabolism*
chemical_list: D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; D011943:Receptors, Adrenergic, beta; D014316:Tritium; C026777:ICI 118551; C025716:ICI 89406; C033394:CGP 12177