title: Spectrum of disorders associated with enlarged sylvian fissures in infancy.
abstract: Disproportionate enlargement of the sylvian fissures (ESF) on MRI of an infant's CNS suggests underdevelopment of the cortical operculum. We reviewed charts of infants with isolated ESF. Conditions associated with ESF included feeding difficulties and facial dysmorphism (syndromic or nonsyndromic). There may be an embryologic link between growth of the opercular cortex and development of the face.
authors.affiliation: Division of Neurology, Children's Hospital of Philadelphia, PA 19104, USA.
authors.forename: P M
authors.initials: PM
authors.lastname: Bingham
authors.forename: B
authors.initials: B
authors.lastname: Parrish
authors.forename: S C
authors.initials: SC
authors.lastname: Chen
authors.forename: N
authors.initials: N
authors.lastname: Canto-Moreira
authors.forename: R A
authors.initials: RA
authors.lastname: Zimmerman
mesh_terms: D002540:Cerebral Cortex / Q000002:abnormalities*; D002648:Child; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D004827:Epilepsy / Q000175:diagnosis / Q000473:pathology; D005147:Facial Bones / Q000002:abnormalities; D001068:Feeding and Eating Disorders / Q000209:etiology; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008831:Microcephaly / Q000139:chemically induced / Q000150:complications / Q000473:pathology*