[The immunomodulating and antioxidants actions of plant preparations and abisib in disordered lipid metabolism].
Five intraventricular injections of phytopreparations lohein and abisib in a dose of 0.2 or 0.5 ml stimulated dose-dependently the development of a T-dependent and T-independent immune responses in rats kept on the usual diet, and increased or normalized the development of these processes in rats kept on a atherogenic diet. The drugs lessened lipid peroxidation and the biochemical syndromes of hepatocyte affection in animals given an atherogenic diet. The immunomodulating effect of phytopreparations is mediated by cytokines of adherent and nonadherent splenic cells, the biochemical effects only by cytokines of adherent splenocytes.
Uteshev
B S
BS
Department of Pharmacology, Russian State Medical University, Moscow, Russia.
Baĭburin
F Ia
FIa
Prokopenko
L G
LG
D028202:Abies; D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D000975:Antioxidants / Q000627:therapeutic use*; D004036:Diet, Atherogenic; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006949:Hyperlipidemias / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D007111:Immunity, Cellular / Q000187:drug effects; D007114:Immunization; D050356:Lipid Metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D014197:Trees
D000276:Adjuvants, Immunologic; D000975:Antioxidants; D010936:Plant Extracts; C116315:abisib; C108292:lochein
Immunomoduliruiushchee i antioksidantnoe deĭstvie fitopreparatov i abisib pri narushenii lipidnogo obmena.