DNA cleaving activities of 9-membered masked enediyne analogues possessing DNA intercalator and sugar moieties.
The DNA cleaving properties of various enediyne analogues possessing sugar moieties and DNA-intercalators were investigated. The DNA cleaving experiments show that these hybrids analogues induced sequence-selective DNA cleavage and the simple sugars in the enediyne serve as a DNA recognition element for DNA cleavage.
Takahashi
T
T
Department of Chemical Engineering, Tokyo Institute of Technology, Japan.
Tanaka
H
H
Matsuda
A
A
Doi
T
T
Yamada
H
H
Matsumoto
T
T
Sasaki
D
D
Sugiura
Y
Y
D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D001483:Base Sequence; D002241:Carbohydrates; D004247:DNA / Q000187:drug effects* / Q000378:metabolism; D007364:Intercalating Agents / Q000494:pharmacology*; D008969:Molecular Sequence Data; D013329:Structure-Activity Relationship
D000903:Antibiotics, Antineoplastic; D002241:Carbohydrates; D007364:Intercalating Agents; D004247:DNA