[A comparative analysis of energy process inhibitors on the efficiency of phage infection in staphylococci].
The study of the effect of KCN, DCCD and CCCP as inhibitors of the energy yielding processes showed that the efficacy of phage infection depended on respiration, proton ATPase, and proton electrochemical potential of hydrogen ions. There was a 49.5-68.0% decrease of the efficacy of phage infection after addition of the above mentioned inhibitors at the period of the contact of cells with bacteriophages at the stage of the phage nucleic acid transfer. The Embden-Meyerhof-Parnas route inhibitors NaF and CH2ICOOH less affected the efficacy of phage infection. The same effect was observed during addition of Na3AsO4 as the ATP synthesis inhibitor. This efficacy decrease was probably due the inhibition of the processes of the substrate level phosphorylation and the deplete of the intracellular ATP content.
Polishko
T N
TN
Dniepropetrovsk State University.
D003470:Culture Media; D003864:Depression, Chemical; D004352:Drug Resistance, Microbial; D004734:Energy Metabolism / Q000187:drug effects*; D013204:Staphylococcus Phages / Q000187:drug effects* / Q000472:pathogenicity; D013211:Staphylococcus aureus / Q000378:metabolism / Q000821:virology
D003470:Culture Media
Sravnitel'nyĭ analiz vozdeĭstviia ingibitorov énergeticheskikh protsessov na éffektivnost' fagovoĭ infektsii u stafilokokkov.