[Utility of gamma rays in prophylaxis of transmissible malaria by blood transfusion].
This study was carried out to evaluate the fortuitons advantage of using gamma irradiation in the prophylaxis of transmissible malaria by blood transfusion, with mice as the experimental model. In the first step, when the infected blood with Plasmodium berghei was submitted to 2,500 rad and 5,000 rad, with or without metronidazol, there was no success, because the animals presented parasitaemia and died after inoculation of irradiated blood. However, there was partial success in the second step, when the infected blood received 10,000 and 15,000 rad, and was inoculated in mice, which showed infection, and presented a survival rate of 20% and 40%, respectively, with later negativation of blood infected by P. berghei.
Braz
L M
LM
Laboratório de Investigação Médica-Parasitologia do Hospital das Clínicas, da Faculdade de Medicina da Universidade de São Paulo, Brasil. lmabraz@usp.br
Amato Neto
V
V
Carignani
F L
FL
Fernandes
A O
AO
Hamerschlak
N
N
Zuanella
L S
LS
Silva
M de F
Mde F
de Souza
I L
IL
Okumura
M
M
D000818:Animals; D001769:Blood / Q000469:parasitology / Q000528:radiation effects*; D001803:Blood Transfusion / Q000379:methods*; D005720:Gamma Rays / Q000627:therapeutic use*; D008288:Malaria / Q000517:prevention & control* / Q000635:transmission*; D051379:Mice; D008807:Mice, Inbred BALB C; D010962:Plasmodium berghei / Q000528:radiation effects
Estudo sobre a eventual utilidade de raios gama na profilaxia da malária transmissível por transfusão de sangue.