title: New taxanes as highly efficient reversal agents for multidrug resistance in cancer cells.
abstract: New non-cytotoxic taxanes synthesized from 10-deacetylbaccatin III and special hydrophobic acylating agents show remarkable MDR reversal activity (< or = 99.8%) against drug-resistant human breast cancer cells when co-administered with paclitaxel or doxorubicin. This activity is ascribed to the highly efficient blocking of P-glycoprotein efflux by these new taxanes.
authors.affiliation: Department of Chemistry, State University of New York at Stony Brook 11794-3400, USA.
authors.forename: I
authors.initials: I
authors.lastname: Ojima
authors.forename: P Y
authors.initials: PY
authors.lastname: Bounaud
authors.forename: C
authors.initials: C
authors.lastname: Takeuchi
authors.forename: P
authors.initials: P
authors.lastname: Pera
authors.forename: R J
authors.initials: RJ
authors.lastname: Bernacki
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism; D000818:Animals; D004305:Dose-Response Relationship, Drug; D018432:Drug Resistance, Multiple; D006801:Humans; D013329:Structure-Activity Relationship; D043823:Taxoids; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D043823:Taxoids; D014315:Triterpenes; C042213:10-deacetylbaccatine III