beta Gal(1-->S-4)beta GlcNac--OR: a galactosidase-stable substrate for alpha(1-->3)fucosyltransferase.
1'-4 Thio-N-acetyllactosamine was chemically synthesized as a galactosidase-stable substrate for alpha(1-->3)fucosyltransferase. The product of enzymatic fucose addition was confirmed to be the thio-Le X analog.
Ding
Y
Y
Department of Chemistry, University of Alberta, Edmonton, Canada.
Hindsgaul
O
O
Li
H
H
Palcic
M M
MM
D000606:Amino Sugars / Q000138:chemical synthesis* / Q000378:metabolism; D005647:Fucosyltransferases / Q000378:metabolism*; D005696:Galactosidases / Q000378:metabolism*; D006801:Humans
D000606:Amino Sugars; C000458:N-acetyllactosamine; D005647:Fucosyltransferases; C031692:galactoside 3-fucosyltransferase; D005696:Galactosidases