title: [A patient with rapidly progressing renal failure, florid syphilis and positive HIV serology].
abstract: We describe the frist reported case in Switzerland of HIV-associated nephropathy (HIVAN). HIVAN shows a typical combination of clinical findings: black race, proteinuria, large hyper-echogenic kidneys, normal blood pressure, positive HIV serology and no autoantibodies. The histologic findings are typical: focal segmental glomerulosclerosis of the collapsing variant, often with marked interstitial nephritis. The disease normally appears before AIDS symptoms develop and follows a very aggressive course to end-stage renal disease. Therapy consists of a combination of nucleoside reverse transcriptase and proteinase inhibitors, ACE inhibitors, and possibly steroids. In end-stage renal disease patients can be managed by haemodialysis, continuous ambulatory peritoneal dialysis (CAPD) or kidney transplantation.
authors.affiliation: Abteilung für Nephrologie, Kantonsspital Luzern.
authors.forename: H R
authors.initials: HR
authors.lastname: Räz
authors.forename: V
authors.initials: V
authors.lastname: Nickeleit
authors.forename: M J
authors.initials: MJ
authors.lastname: Mihatsch
authors.forename: A
authors.initials: A
authors.lastname: Colombi
mesh_terms: D016263:AIDS-Associated Nephropathy / Q000175:diagnosis* / Q000628:therapy; D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis* / Q000628:therapy; D000328:Adult; D001706:Biopsy; D044383:Black People; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000175:diagnosis / Q000628:therapy; D006679:HIV Seropositivity / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D007668:Kidney / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000175:diagnosis* / Q000628:therapy; D007677:Kidney Function Tests; D008854:Microscopy, Electron; D009395:Nephritis, Interstitial / Q000175:diagnosis / Q000628:therapy; D013587:Syphilis / Q000175:diagnosis* / Q000628:therapy
vernacular_title: Eine Patientin mit rasch progredienter Niereninsuffizienz, florider Lues und positiver HIV-Serologie.