title: A mixed resin bed for the quenching and purification of tetrabutylammonium fluoride mediated desilylating reactions.
abstract: A polymer-bound calcium sulfonate resin is prepared and used to sequester tetrabutylammonium fluoride. The simultaneous use of the calcium sulfonate resin with a sulfonic acid resin is used for the quenching and purification of desilylating reactions involving tetrabutylammonium fluoride as the reagent. Employment of this resin workup technique eliminates the need for a liquid-phase extractive protocol allowing the procedure to be easily automated.
authors.affiliation: Parallel Medicinal and Combinatorial Chemistry, Searle Discovery Research-U2D Monsanto Company, St. Louis, MO 63167, USA.
authors.forename: J J
authors.initials: JJ
authors.lastname: Parlow
authors.forename: M L
authors.initials: ML
authors.lastname: Vazquez
authors.forename: D L
authors.initials: DL
authors.lastname: Flynn
mesh_terms: D001331:Automation; D002625:Chemistry, Organic / Q000379:methods*; D003902:Detergents; D005459:Fluorides; D007202:Indicators and Reagents; D007700:Kinetics; D008968:Molecular Conformation; D015394:Molecular Structure; D000644:Quaternary Ammonium Compounds; D012117:Resins, Synthetic; D012821:Silanes; D013329:Structure-Activity Relationship
chemical_list: D003902:Detergents; D007202:Indicators and Reagents; D000644:Quaternary Ammonium Compounds; D012117:Resins, Synthetic; D012821:Silanes; C009405:tetrabutylammonium; D005459:Fluorides