title: Synthesis and evaluation of artificial taxoids with antitumor and multi-drug resistance reversing activities.
abstract: Artificial taxoids were synthesized and subjected to evaluation of their ability of multi-drug resistance reversing and antitumor activities. While the taxoid 4 could not increase cellular accumulation of vincristine in multi-drug resistant tumor cells, the C4-hydroxy analog 15 showed significant effect. However, these compounds showed weak activities on growth inhibition of cancer cells.
authors.affiliation: Department of Chemistry, Tokyo Institute of Technology, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Morihira
authors.forename: T
authors.initials: T
authors.lastname: Nishimori
authors.forename: H
authors.initials: H
authors.lastname: Kusama
authors.forename: Y
authors.initials: Y
authors.lastname: Horiguchi
authors.forename: I
authors.initials: I
authors.lastname: Kuwajima
authors.forename: T
authors.initials: T
authors.lastname: Tsuruo
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000037:antagonists & inhibitors*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D015195:Drug Design; D018432:Drug Resistance, Multiple; D006801:Humans; D017239:Paclitaxel / Q000031:analogs & derivatives*; D013329:Structure-Activity Relationship
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000970:Antineoplastic Agents; D017239:Paclitaxel