title: Preclinical antitumor efficacy of analogs of XK469: sodium-(2-[4-(7-chloro-2-quinoxalinyloxy)phenoxy]propionate.
abstract: A series of quinoxaline analogs of the herbicide Assure was found to have selective cytotoxicity for solid tumors of mice in a disk-diffusion-soft-agar-colony-formation-assay compared to L1210 leukemia. Four agents without selective cytotoxicity and 14 agents with selective cytotoxicity were evaluated in vivo for activity against a solid tumor. The four agents without selective cytotoxicity in the disk-assay were inactive in vivo (T/C > 42%). Thirteen of the fourteen agents with selectivity in the disk-assay were active in vivo (T/C < 42%). Five of the agents had curative activity. These five agents had a halogen (F, Cl, Br) in the 7-position (whereas Assure had a CI in the 6 position). All agents with curative activity were either a carboxylic acid, or a derivative thereof, whereas Assure is the ethyl ester of the carboxylic acid. All other structural features were identical between Assure and the curative agents. Assure had no selective cytotoxicity for solid tumors in the disk-assay, and was devoid of antitumor activity. The analog XK469 is in clinical development.
authors.affiliation: Wayne State University, School of Medicine, Detroit 48202, USA.
authors.forename: T H
authors.initials: TH
authors.lastname: Corbett
authors.forename: P
authors.initials: P
authors.lastname: LoRusso
authors.forename: L
authors.initials: L
authors.lastname: Demchick
authors.forename: C
authors.initials: C
authors.lastname: Simpson
authors.forename: S
authors.initials: S
authors.lastname: Pugh
authors.forename: K
authors.initials: K
authors.lastname: White
authors.forename: J
authors.initials: J
authors.lastname: Kushner
authors.forename: L
authors.initials: L
authors.lastname: Polin
authors.forename: J
authors.initials: J
authors.lastname: Meyer
authors.forename: J
authors.initials: J
authors.lastname: Czarnecki
authors.forename: L
authors.initials: L
authors.lastname: Heilbrun
authors.forename: J P
authors.initials: JP
authors.lastname: Horwitz
authors.forename: J L
authors.initials: JL
authors.lastname: Gross
authors.forename: C H
authors.initials: CH
authors.lastname: Behrens
authors.forename: B A
authors.initials: BA
authors.lastname: Harrison
authors.forename: R J
authors.initials: RJ
authors.lastname: McRipley
authors.forename: G
authors.initials: G
authors.lastname: Trainor
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D008297:Male; D051379:Mice; D015394:Molecular Structure; D011810:Quinoxalines / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D011810:Quinoxalines; C118180:XK 469