[Basic substituted thieno(3,4-d)pyrimidine carboxylic acids: synthesis via ANRORC-reaction starting from 7-cyanthieno(3,2-d)oxazines].
The synthesis of 7-cyan-thieno[3,2-d]-1,3-oxazine 7 is reported. Reaction of 7 with primary amines gives the thieno[3,4-d]pyrimidincarboxylic acids 14 in a unusual ring transformation. Several synthesized compounds were tested as antiallergic agents.
Briel
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Institut für Pharmazie, Universität Leipzig, Germany.
D000818:Animals; D018926:Anti-Allergic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D010078:Oxazines / Q000138:chemical synthesis / Q000737:chemistry*; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013876:Thiophenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
D018926:Anti-Allergic Agents; D010078:Oxazines; D011743:Pyrimidines; D013876:Thiophenes
Basisch substituierte Thieno[3,4-d]pyrimidincarbonsäuren: Synthese durch ANRORC-Reaktion aus 7-Cyan-thieno[3,2-d]-oxazinen und biologische Aktivität.