title: Novel HIV-protease inhibitors containing beta-hydroxyether and -thioether dipeptide isostere surrogates: modification of the P3 ligand.
abstract: Studies involving modifications to the P3 position of previously described HIV-protease inhibitors containing beta-hydroxyether and thioether dipeptide isostere replacements led to the discovery of pseudopeptides 8o and 8p with improved antiviral activities.
authors.affiliation: Schering-Plough Research Institute, Kenilworth, New Jersey 07033, USA.
authors.forename: N M
authors.initials: NM
authors.lastname: Patel
authors.forename: F
authors.initials: F
authors.lastname: Bennett
authors.forename: V M
authors.initials: VM
authors.lastname: Girijavallabhan
authors.forename: B
authors.initials: B
authors.lastname: Dasmahapatra
authors.forename: N
authors.initials: N
authors.lastname: Butkiewicz
authors.forename: A
authors.initials: A
authors.lastname: Hart
mesh_terms: D004151:Dipeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004987:Ethers; D006678:HIV / Q000187:drug effects*; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D004151:Dipeptides; D004987:Ethers; D017320:HIV Protease Inhibitors