title: Acute hepatic failure due to hepatosplenic B-cell non-Hodgkin's lymphoma in a patient infected with hepatitis C virus.
abstract: We report a 75-year-old Japanese man infected with hepatitis C virus (HCV) who died of acute hepatic failure due to the hepatic infiltration of B-cell non-Hodgkin's lymphoma (NHL) cells. He suddenly developed jaundice, fatigue, fever, and hepatosplenomegaly during the course of chronic infection with HCV. Postmortem liver necropsy revealed extensive infiltration of lymphoma cells into the liver. Although the association between HCV infection and NHL has recently become a matter of concern, we believe this to be the first reported case of acute hepatic failure caused by hepatic involvement of non-Hodgkin's lymphoma in an HCV-infected patient.
authors.affiliation: Third Department of Internal Medicine, Nara Medical University, Kashihara, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Yamane
authors.forename: S
authors.initials: S
authors.lastname: Yoneda
authors.forename: S
authors.initials: S
authors.lastname: Iwasawa
authors.forename: K
authors.initials: K
authors.lastname: Nishimura
authors.forename: H
authors.initials: H
authors.lastname: Kawamoto
authors.forename: H
authors.initials: H
authors.lastname: Nakano
authors.forename: H
authors.initials: H
authors.lastname: Fukui
authors.forename: H
authors.initials: H
authors.lastname: Nakamine
mesh_terms: D000368:Aged; D017809:Fatal Outcome; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000473:pathology; D006801:Humans; D017093:Liver Failure / Q000209:etiology*; D008113:Liver Neoplasms / Q000150:complications / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000473:pathology; D008297:Male; D013160:Splenic Neoplasms / Q000150:complications / Q000473:pathology; D014057:Tomography, X-Ray Computed