Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer.
DUSP6 (alias PYST1), one of the dual-specificity tyrosine phosphatases, is localized on 12q21, one of the regions of frequent allelic loss in pancreatic cancer. This gene is composed of three exons, and two forms of alternatively spliced transcripts are ubiquitously expressed. Although no mutations were observed in 26 pancreatic cancer cell lines, reduced expressions of the full-length transcripts were observed in some cell lines, which may suggest some role for DUSP6 in pancreatic carcinogenesis.
Furukawa
T
T
Molecular Pathology, Tohoku University School of Medicine, Sendai; (Japan).
Yatsuoka
T
T
Youssef
E M
EM
Abe
T
T
Yokoyama
T
T
Fukushige
S
S
Soeda
E
E
Hoshi
M
M
Hayashi
Y
Y
Sunamura
M
M
Kobari
M
M
Horii
A
A
D015139:Blotting, Southern; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000235:genetics* / Q000378:metabolism; D004252:DNA Mutational Analysis; D004273:DNA, Neoplasm / Q000032:analysis; D054642:Dual Specificity Phosphatase 6; D005091:Exons / Q000235:genetics; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D015894:Genome, Human; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008969:Molecular Sequence Data; D010190:Pancreatic Neoplasms / Q000201:enzymology / Q000235:genetics*; D017027:Protein Tyrosine Phosphatases / Q000235:genetics* / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013379:Substrate Specificity; D014158:Transcription, Genetic; D014407:Tumor Cells, Cultured
D004273:DNA, Neoplasm; D017871:Calcium-Calmodulin-Dependent Protein Kinases; C517035:DUSP6 protein, human; D054642:Dual Specificity Phosphatase 6; D017027:Protein Tyrosine Phosphatases