title: The biological resolution of malformations of the central nervous system.
abstract: It has been known for years that the assembly of the nervous system is under genetic control. During the last 10 years, the genes that direct the formation of the brain and spinal cord have begun to be discovered at an amazing pace. Mutations in the fruit fly and advances in molecular genetics have led the way. Gene mutations that cause many of the malformations of the human brain and spinal cord are now known. This has many physician-scientists hoping that an understanding of cause might lead to cure.
authors.affiliation: Pediatric Neurosurgery, Children's Memorial Hospital, Chicago, IL 60614-3394, USA.
authors.forename: D G
authors.initials: DG
authors.lastname: McLone
mesh_terms: D000818:Animals; D001139:Arnold-Chiari Malformation / Q000235:genetics; D001921:Brain / Q000196:embryology; D002490:Central Nervous System / Q000002:abnormalities* / Q000196:embryology; D002642:Chick Embryo; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics; D005314:Embryonic and Fetal Development / Q000235:genetics; D005260:Female; D005326:Fetal Proteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D005492:Folic Acid / Q000627:therapeutic use; D005801:Genes, Homeobox; D006801:Humans; D007231:Infant, Newborn; D008067:Lipoma / Q000235:genetics; D008297:Male; D008591:Meningomyelocele / Q000235:genetics; D051379:Mice; D008818:Mice, Neurologic Mutants; D009024:Morphogenesis / Q000235:genetics; D009436:Neural Tube Defects / Q000196:embryology / Q000235:genetics / Q000517:prevention & control; D000072041:PAX3 Transcription Factor; D051761:Paired Box Transcription Factors; D013116:Spinal Cord / Q000196:embryology; D013120:Spinal Cord Neoplasms / Q000235:genetics; D014157:Transcription Factors
chemical_list: D004268:DNA-Binding Proteins; D005326:Fetal Proteins; D000072041:PAX3 Transcription Factor; C489409:PAX3 protein, human; D051761:Paired Box Transcription Factors; D014157:Transcription Factors; C068686:Pax3 protein, mouse; D005492:Folic Acid