Nitrogen-carbon-linked (azolylphenyl)oxazolidinones with potent antibacterial activity against the fastidious gram-negative organisms Haemophilus influenzae and Moraxella catarrhalis.
Genin
M J
MJ
Pharmacia & Upjohn, Inc., Kalamazoo, Michigan 49001, USA.
Hutchinson
D K
DK
Allwine
D A
DA
Hester
J B
JB
Emmert
D E
DE
Garmon
S A
SA
Ford
C W
CW
Zurenko
G E
GE
Hamel
J C
JC
Schaadt
R D
RD
Stapert
D
D
Yagi
B H
BH
Friis
J M
JM
Shobe
E M
EM
Adams
W J
WJ
D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D015169:Colony Count, Microbial; D006193:Haemophilus influenzae / Q000187:drug effects*; D020128:Inhibitory Concentration 50; D007275:Injections, Intravenous; D008297:Male; D051379:Mice; D001936:Moraxella catarrhalis / Q000187:drug effects*; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013203:Staphylococcal Infections / Q000188:drug therapy; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D010080:Oxazoles; C116533:PNU 171933; C116534:PNU 172576; D011720:Pyrazoles; D011758:Pyrroles