NMR and topochemical studies of peptidomimetic HIV-I protease inhibitors containing a cis-epoxide amide isostere.
NMR and topochemical studies of irreversible HIV-1 protease inhibitors containing a cis-epoxide as amide isostere have been carried out to identify conformational preference of the inhibitors in solution. The inhibitors prefer to adopt extended conformations similar to the beta-strand in solution.
Ro
S
S
Biotech Research Institute, LG Chemical Ltd./Research Park, Taejon, Korea.
Baek
S G
SG
Lee
B
B
Park
C
C
Choy
N
N
Lee
C S
CS
Son
Y C
YC
Choi
H
H
Koh
J S
JS
Yoon
H
H
Kim
S C
SC
Ok
J H
JH
D018360:Crystallography, X-Ray; D004852:Epoxy Compounds / Q000737:chemistry; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis / Q000737:chemistry*; D015497:HIV-1; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D008958:Models, Molecular; D018716:Molecular Mimicry; D011487:Protein Conformation
D004852:Epoxy Compounds; D017320:HIV Protease Inhibitors