[Myocardial protection against cold stress with pravastatin].
The CARE study showed that the myocardial infarction recurrence rate in patients with moderate cholesterol blood level decreases early during pravastatin treatment. Our goal is to evaluate the possible role of pravastatin in preventing the myocardial lesions induced by cold stress. Twenty Wistar-EPM rats were divided into four groups: Control (CON); PR (Pravastatin) treated with 10 mg/kg/d for 15 days; S (Stress group) in which the rats were submitted to cold stress (-8 degrees C for four hours); and PR + S group treated with pravastatin like PR group and also submitted to the cold stress. The animals were sacrificed and heart fragments were removed for optic and electronic microscopic analysis. The variable considered was mitochondria abnormality (edema, lyses and vacuolization) that was interpreted as crystolyses indices (CI) (n degree of abnormal mitochondria/n degree total of mitochondria). The following crystolyses indices, were found for each group respectively: CON, 2.0%; S, 95.5%; PR, 19.9% and PR + S group, 27.7%*(*p < 0.01). In conclusion, pravastatin prevented myocardial lesions induced by cold stress significantly.
Póvoa
R
R
Escola Paulista de Medicina-UNIFESP São Paulo, Brasil.
Bombing
M T
MT
Luna Filho
B
B
Simões
M
M
Costa
A
A
Murad
N
N
Ferreira
C
C
Ferreira Filho
C
C
D000818:Animals; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood; D003080:Cold Temperature; D006321:Heart / Q000187:drug effects*; D008297:Male; D008854:Microscopy, Electron; D009203:Myocardial Infarction / Q000097:blood / Q000517:prevention & control; D009206:Myocardium / Q000648:ultrastructure; D017035:Pravastatin / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012008:Recurrence; D013312:Stress, Physiological / Q000188:drug therapy*
D000924:Anticholesteremic Agents; D002784:Cholesterol; D017035:Pravastatin
Protecção miocárdica ao "estresse" do frio pela pravastatina.