title: [Investigation on in vivo metabolism of n-butyl phthalide].
abstract: A GC-MS method for the investigation on the metabolism of n-butyl phthalide (NBP) is described. After oral administration of NBP to rats, urine was collected, hydrolyzed with beta-glucuronidase, extracted and concentrated for TMS derivatization, and then analyzed by GC-MS. HBP and its four oxidative metabolites were determined in 0-24 h, 24-48 h rat urine. The mass spectra of the metabolites and their derivatives were presented and the in vivo metabolic pathway was discussed.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
authors.forename: S H
authors.initials: SH
authors.lastname: Peng
authors.forename: T H
authors.initials: TH
authors.lastname: Zhou
mesh_terms: D000818:Animals; D001572:Benzofurans / Q000378:metabolism*; D008401:Gas Chromatography-Mass Spectrometry; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001572:Benzofurans; C027125:3-n-butylphthalide