Expression of the thrombospondin 1 receptor CD36 is correlated with decreased stromal vascularisation in colon cancer.
Vascularisation is determined by the balance between various angiogenic and angio-inhibitory factors in cancer stroma. CD36 is a cell adhesion receptor shown to interact with the ligand thrombospondin 1 (TSP1). It has not been determined whether the interaction of TSP1 and its receptor CD36 is correlated with vascularisation or clinical outcome of malignant tumours in vivo. We studied the correlations between expression of TSP1, CD36 and vascularisation and prognosis in 65 colon cancers. Various levels of TSP1 gene expression were observed in 27 of 65 colon cancers. CD36 expression was detected in 33 of 65 cancers, and was significantly correlated with decreased stromal vascularisation (P<0.001). The colon cancers expressing CD36 showed better prognosis (P<0.01). TSP1 expression levels did not affect CD36 expression. These results suggested that CD36 expression which decreased stromal vascularisation is correlated with better prognosis of colon cancer.
Tsuchida
T
T
Department of Pathology, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-1193, Japan.
Kijima
H
H
Tokunaga
T
T
Oshika
Y
Y
Hatanaka
H
H
Fukushima
Y
Y
Abe
Y
Y
Kawai
K
K
Yoshida
Y
Y
Miura
S
S
Yamazaki
H
H
Tamaoki
N
N
Ueyama
Y
Y
Nakamura
M
M
D018955:CD36 Antigens / Q000032:analysis* / Q000235:genetics; D003110:Colonic Neoplasms / Q000098:blood supply* / Q000737:chemistry* / Q000401:mortality; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D019700:Thrombospondin 1 / Q000235:genetics
D018955:CD36 Antigens; D019700:Thrombospondin 1