title: Sugar transporters from bacteria, parasites and mammals: structure-activity relationships.
abstract: Sugar transport across the plasma membrane is one of the most important transport processes. The cloning and expression of cDNAs from a superfamily of related sugar transporters that all adopt a 12-membrane-spanning-domain structure has opened new avenues of investigation, including presteady-state kinetic analysis. Structure-function analyses of mammalian and bacterial sugar transporters, and comparisons of these transporters with those of parasitic trypanosomatids, indicate that different environmental pressures have tailored the evolution of the various members of the sugar-transporter superfamily. Subtle distinctions in the function of these proteins can be related to particular amino acid residue substitutions.
authors.affiliation: Division of Infection and Immunity, University of Glasgow, UK.
authors.forename: A R
authors.initials: AR
authors.lastname: Walmsley
authors.forename: M P
authors.initials: MP
authors.lastname: Barrett
authors.forename: F
authors.initials: F
authors.lastname: Bringaud
authors.forename: G W
authors.initials: GW
authors.lastname: Gould
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001426:Bacterial Proteins / Q000737:chemistry* / Q000378:metabolism; D001665:Binding Sites; D001692:Biological Transport; D002135:Calcium-Binding Proteins; D050260:Carbohydrate Metabolism; D002352:Carrier Proteins / Q000737:chemistry* / Q000378:metabolism*; D003571:Cytochalasin B / Q000378:metabolism; D051272:Glucose Transporter Type 1; D008322:Mammals; D008969:Molecular Sequence Data; D009004:Monosaccharide Transport Proteins / Q000737:chemistry / Q000378:metabolism; D010271:Parasites; D033902:Periplasmic Binding Proteins; D011487:Protein Conformation; D017386:Sequence Homology, Amino Acid; D013329:Structure-Activity Relationship
chemical_list: D001426:Bacterial Proteins; D002135:Calcium-Binding Proteins; D002352:Carrier Proteins; D051272:Glucose Transporter Type 1; D009004:Monosaccharide Transport Proteins; D033902:Periplasmic Binding Proteins; C023550:galactose-binding protein; D003571:Cytochalasin B