Chemical inducers of dimerization: the atomic structure of FKBP12-FK1012A-FKBP12.
A ligand that simultaneously binds two proteins must have two high affinity protein binding domains joined in a fashion that facilitates, or at least does not prevent, protein-protein interaction. Designing such ligands is challenging, and a high resolution X-ray structure of FKBP12-FK1012A-FKBP12 illustrates the subtleties of one successful design.
Schultz
L W
LW
Department of Chemistry, Cornell University, Ithaca, NY 14853-1301, USA.
Clardy
J
J
D019281:Dimerization; D020104:Immunophilins / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D016559:Tacrolimus / Q000031:analogs & derivatives* / Q000737:chemistry; D022021:Tacrolimus Binding Proteins
C084260:FK 1012; D022021:Tacrolimus Binding Proteins; D020104:Immunophilins; D016559:Tacrolimus