Solid-phase synthesis of N-substituted amidinophenoxy pyridines as factor XA inhibitors.
An arylamidine linker has been employed for the solid-phase synthesis of N-substituted amidinoaryloxypyridine analogs 2 via nucleophilic substitution on a fluoropyridyl template. Two novel N-substituted amidinoaryloxypyridine derivatives 2a and 2b were discovered via this approach.
Mohan
R
R
Pharmaceuticals Discovery, Berlex Biosciences, Richmond, CA 94804, USA.
Yun
W
W
Buckman
B O
BO
Liang
A
A
Trinh
L
L
Morrissey
M M
MM
D065427:Factor Xa Inhibitors; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015842:Serine Proteinase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
D065427:Factor Xa Inhibitors; D011725:Pyridines; D015842:Serine Proteinase Inhibitors