title: Albumin infusion in humans does not model exercise induced hypervolaemia after 24 hours.
abstract: We rapidly infused 234 +/- 3 mL of 5% human serum albumin in eight men while measuring haematocrit, haemoglobin concentration, plasma volume (PV), albumin concentration, total protein concentration, osmolality, sodium concentration, renin activity, aldosterone concentration, and atrial natriuretic peptide concentration to test the hypotheses that plasma volume expansion and plasma albumin content expansion will not persist for 24 h. Plasma volume and albumin content were expanded for the first 6 h after infusion (44.3 +/- 1.9-47.2 +/- 2.0 mL kg-1 and 1.9 +/- 0.1-2.1 +/- 0.1 g kg-1 at pre-infusion and 1 h, respectively, P < 0.05), but by 24 h plasma volume and albumin content decreased significantly from 1 h post-infusion and were not different from pre-infusion (44.8 +/- 1.9 mL kg-1 and 1.9 +/- 0.1 g kg-1, respectively). Plasma aldosterone concentration showed a significant effect of time over the 24 h after infusion (P < 0.05), and showed a trend to decrease at 2 h after infusion (167.6 +/- 32.5(-1) 06.2 +/- 13.4 pg mL-1, P = 0.07). These data demonstrate that a 6.8% expansion of plasma volume and 10.5% expansion of plasma albumin content by infusion does not remain in the vascular space for 24 h and suggest a redistribution occurs between the intravascular space and interstitial fluid space.
authors.affiliation: John B. Pierce Laboratory, New Haven, CT 06519, USA.
authors.forename: A
authors.initials: A
authors.lastname: Haskell
authors.forename: C M
authors.initials: CM
authors.lastname: Gillen
authors.forename: G W
authors.initials: GW
authors.lastname: Mack
authors.forename: E R
authors.initials: ER
authors.lastname: Nadel
mesh_terms: D000328:Adult; D000450:Aldosterone / Q000097:blood; D009320:Atrial Natriuretic Factor / Q000097:blood; D001798:Blood Proteins; D015444:Exercise / Q000502:physiology*; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D009994:Osmolar Concentration; D010953:Plasma Volume / Q000187:drug effects* / Q000502:physiology; D012083:Renin / Q000097:blood; D012709:Serum Albumin / Q000008:administration & dosage* / Q000032:analysis; D012964:Sodium / Q000097:blood
chemical_list: D001798:Blood Proteins; D006454:Hemoglobins; D012709:Serum Albumin; D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D012964:Sodium; D012083:Renin