Preparation, characterization, and dissolution studies of ibuprofen solid dispersions using polyethylene glycol (PEG), talc, and PEG-talc as dispersion carriers.
Solid dispersions of ibuprofen (IBF) were prepared by solvent evaporation method using polyethylene glycol 10000 (PEG), talc, and PEG-talc as dispersion carriers. The drug-carrier(s) interactions in the solid state were investigated using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and x-ray diffraction analysis. Interactions in the solution were studied by performing dissolution experiments. No important and well-defined chemical interaction was found between the ingredients. The increase in the IBF dissolution rate from the solid dispersions with the carriers used in this study could be attributed to several factors such as improved wettability, local solubilization, and drug particle size reduction.
Khan
G M
GM
Zhong Kun Pharmaceutical Research Institute, School of Pharmacy, China Pharmaceutical University, Nanjing, People's Republic of China.
Jiabi
Z
Z
D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage / Q000737:chemistry / Q000302:isolation & purification*; D066298:In Vitro Techniques; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D014677:Pharmaceutical Vehicles; D011092:Polyethylene Glycols; D012995:Solubility; D013627:Talc; D014961:X-Ray Diffraction
D014677:Pharmaceutical Vehicles; D013627:Talc; D011092:Polyethylene Glycols; D007052:Ibuprofen