[Markers of hemostatic activation in the coronary sinus versus peripheral circulation in coronary artery disease. Effects of percutaneous transluminal coronary angioplasty].
BACKGROUND
To evaluate haemostatic changes in coronary sinus (CS) and peripheral circulation (PC) in patients with cardiovascular disease (CAD) following PTCA.


METHODS
We studied 12 patients scheduled for elective PTCA. Blood samples were obtained from CS and PC before angioplasty and after each balloon dilation. Expression of P selectin and several haemostatic parameters were determined.


RESULTS
D-Dimers (DD) plasma levels were significantly increased in samples from CS. No significant differences were found in other haemostatic parameters. A significant decrease of thrombin-antithrombin III levels after PTCA was assessed.


CONCLUSIONS
Intracoronary and peripheral hemostatic activation does not occur during and immediately following PTCA. No major differences in hemostatic parameters between CS and PC were observed in patients with CAD.
Marín-Blázquez
M D
MD
Unidad de Oncohematología, Hospital General Universitario, Murcia.
Zuazu-Jausoro
I
I
Rivera
J
J
Sánchez
I
I
Valdés
M
M
Vicente
V
V
D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000379:methods*; D000991:Antithrombins / Q000032:analysis*; D015415:Biomarkers; D002346:Carotid Sinus / Q000502:physiology*; D003326:Coronary Circulation; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000175:diagnosis* / Q000628:therapy*; D013917:Thrombin / Q000032:analysis*; D010959:Tissue Plasminogen Activator / Q000032:analysis*
D000991:Antithrombins; D015415:Biomarkers; D013917:Thrombin; D010959:Tissue Plasminogen Activator
Marcadores de la hemostasia en el seno coronario y en la circulación periférica en la enfermedad coronaria. Efecto de la angioplastia transluminal, percutánea.