title: Structural insight into the binding motifs for the calcium ion and the non-catalytic zinc in matrix metalloproteases.
abstract: The binding motifs for the structural zinc and calcium ions in matrix metalloproteases (MMPs) were investigated by analyzing the three-dimensional structural models of 23 representative MMPs.
authors.affiliation: Department of Chemistry, Wayne State University, Detroit, MI 48202-3489, USA.
authors.forename: I
authors.initials: I
authors.lastname: Massova
authors.forename: L P
authors.initials: LP
authors.lastname: Kotra
authors.forename: S
authors.initials: S
authors.lastname: Mobashery
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D020134:Catalytic Domain; D002645:Chickens; D006801:Humans; D053505:Matrix Metalloproteinases, Secreted; D008666:Metalloendopeptidases / Q000737:chemistry* / Q000378:metabolism*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary; D011898:Ranidae; D012455:Salamandridae; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D013552:Swine; D015032:Zinc / Q000378:metabolism*
chemical_list: D053505:Matrix Metalloproteinases, Secreted; D008666:Metalloendopeptidases; C108362:matrix metalloproteinase 19; D015032:Zinc; D002118:Calcium