Effect of intravenous alfacalcidol on lymphocyte phenotyping in hemodialysis patients.
Chronic renal failure is associated with decreased production of active vitamin D and also results in altered lymphocyte population. We studied the effect of alfacalcidol on lymphocyte phenotype. There were 15 patients (10 males, 5 females) with a mean age of 54.3+/-14.4 years who had been on chronic maintenance haemodialysis for a mean period of 3.2+/-1.5 years. Intravenous alfacalcidol was given three times weekly during dialysis for a duration of 6 months. Our results show a significant increase in NK cells from 0.20+/-0.12 to 0.27+/-0.28 (P=0.001), without a significant change in CD2, CD19, CD4, CD8 population, and CD4/CD8 ratio.
Huraib
S
S
Department of Medicine, King Fahad National Guard Hospital, Riyadh, Kingdom of Saudi Arabia.
Tanimu
D
D
Abu-Romeh
S
S
al-Khairy
K
K
Quadri
K
K
al-Ghamdi
G
G
Iqbal
A
A
D000276:Adjuvants, Immunologic / Q000008:administration & dosage* / Q000494:pharmacology; D000328:Adult; D000368:Aged; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols / Q000008:administration & dosage* / Q000494:pharmacology; D016130:Immunophenotyping / Q000379:methods / Q000706:statistics & numerical data; D007262:Infusions, Intravenous; D007676:Kidney Failure, Chronic / Q000097:blood / Q000276:immunology / Q000628:therapy; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D006435:Renal Dialysis; D013997:Time Factors
D000276:Adjuvants, Immunologic; D006887:Hydroxycholecalciferols; D010281:Parathyroid Hormone; D002118:Calcium; C008088:alfacalcidol