title: Tropane-based amino acids for peptide structure-function studies: inhibitors of platelet aggregation.
abstract: Novel tropane (azabicycloheptane) and azabicyclohexane containing amino acids have been prepared and incorporated into analogues of reported inhibitors of platelet aggregation. The influence of these central constraints upon biological activity suggest their utility in peptide structure function studies.
authors.affiliation: Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia. Phil.Thompson@boxhill.med.monash.edu.au
authors.forename: P E
authors.initials: PE
authors.lastname: Thompson
authors.forename: D L
authors.initials: DL
authors.lastname: Steer
authors.forename: M I
authors.initials: MI
authors.lastname: Aguilar
authors.forename: M T
authors.initials: MT
authors.lastname: Hearn
mesh_terms: D000596:Amino Acids / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014326:Tropanes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000596:Amino Acids; D010455:Peptides; D010975:Platelet Aggregation Inhibitors; D014326:Tropanes