Synthesis of some hydroxynaphthazarins and their cardioprotective effects under ischemia-reperfusion in vivo.
A series of hydroxynaphthazarins has been synthesized. Some of them were found in in vivo experiments to be protectors of myocardium under ischemia-reperfusion and to reduce the infarction zone by 50% without any adverse effect. All compounds exhibit a moderate or small toxicity and are active in low doses.
Anufriev VPh
Pacific Institute of Bioorganic Chemistry, Russian Academy of Sciences, Vladivostok, Russia. anufriev@piboc.marine.su
Novikov
V L
VL
Maximov
O B
OB
Elyakov
G B
GB
Levitsky
D O
DO
Lebedev
A V
AV
Sadretdinov
S M
SM
Shvilkin
A V
AV
Afonskaya
N I
NI
Ruda MYa
Cherpachenko
N M
NM
D000818:Animals; D006900:Hydroxylation; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D008956:Models, Chemical; D009203:Myocardial Infarction / Q000517:prevention & control*; D009285:Naphthoquinones / Q000138:chemical synthesis* / Q000494:pharmacology; D005996:Nitroglycerin / Q000494:pharmacology; D011817:Rabbits; D014665:Vasodilator Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D014700:Verapamil / Q000494:pharmacology
D009285:Naphthoquinones; D014665:Vasodilator Agents; C005503:naphthazarin; D014700:Verapamil; D005996:Nitroglycerin