[The protective effect of captopril on the ischemic myocardium in dogs through coronary sinus retroperfusion].
The protective effect of coronary sinus retroperfusion of Captopril on the ischemic myocardium was observed in dogs with acute myocardial infarction (AMI). The results showed that the infarction size and the level of coronary sinus plasma endothelin (ET) and manodialdenyde (MDA) were smaller and lower when Captopril was administered by coronary sinus retroperfusion than that by systemic intravenous injection. These results suggest that (1) Captopril can be distributed adequately in the local ischemic myocardial zones when administered by coronary sinus retroperfusion in the presence of coronary artery occlusion, (2) Captopril can more effectively protect ischemic myocardium by inhibition of the ET release and against the oxygen free radicals in ischemic myocardial area when used by coronary sinus retroperfusion.
Zeng
X
X
Department of Medicine, Xiangya Hospital, Hunan Medical University, Changsha.
Zhang
J
J
Tang
C
C
D000818:Animals; D002216:Captopril / Q000008:administration & dosage / Q000494:pharmacology*; D003331:Coronary Vessels; D004285:Dogs; D016232:Endothelins / Q000097:blood*; D005260:Female; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000494:pharmacology*; D007275:Injections, Intravenous; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009203:Myocardial Infarction / Q000517:prevention & control*
D016232:Endothelins; D016166:Free Radical Scavengers; D008315:Malondialdehyde; D002216:Captopril