Aryl C-glycosides: physiologically stable glycomimetics of sialyl Lewis X.
In the course of the search for physiologically stable, structurally simple, and low molecular weight sLeX mimetics, aryl C-glycosides with carboxylic acid functionality 2 were found to be extremely potent inhibitors against L- and P-selectins with IC50 in the low microM range.
Kuribayashi
T
T
Exploratory Chemistry Research Laboratories, Sankyo Co. Ltd., Tokyo, Japan.
Ohkawa
N
N
Satoh
S
S
D006027:Glycosides / Q000494:pharmacology*; D019041:L-Selectin / Q000187:drug effects*; D009844:Oligosaccharides / Q000494:pharmacology*; D019007:P-Selectin / Q000187:drug effects*; D000080506:Sialyl Lewis X Antigen; D013329:Structure-Activity Relationship
D006027:Glycosides; D009844:Oligosaccharides; D019007:P-Selectin; D000080506:Sialyl Lewis X Antigen; D019041:L-Selectin