Elastin of the umbilical cord arteries and its alterations in EPH gestosis (preeclampsia).
Edema, proteinuria, hypertension (EPH) gestosis is accompanied by an increase of collagen content and premature replacement of hyaluronic acid by sulfated glycosaminoglycans both in the umbilical cord arteries and in Wharton's jelly. The effect of EPH gestosis on elastin content and metabolism in the umbilical cord arterial wall was the aim of this work. Studies were performed on normal umbilical cord arteries and those taken from newborns of mothers with EPH gestosis. Elastin was isolated from the arterial wall and quantified by a dye-binding method. Biosynthesis and degradation of this protein was evaluated by a pulse-chase experiment with the use of 14C-proline. It was found that EPH gestosis is associated with a significant reduction of elastin content in the umbilical cord arteries as a result of decrease in elastin biosynthesis rate and accelerated degradation of this protein. The replacement of elastin by collagen, and hyaluronate by sulfated glycosaminoglycans, may decrease the hydration of arterial wall and reduce its elasticity. Such rearrangement of extracellular matrix of the umbilical cord arteries may affect mechanical properties of these vessels and disturb fetal blood circulation.
Pawlicka
E
E
Department of Biochemistry, Academy of Medicine, Bialystok, Poland.
Bańkowski
E
E
Jaworski
S
S
D002250:Carbon Radioisotopes; D004549:Elastin / Q000378:metabolism*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007700:Kinetics; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D011392:Proline / Q000378:metabolism; D014469:Umbilical Arteries / Q000378:metabolism*
D002250:Carbon Radioisotopes; D004549:Elastin; D011392:Proline