title: Design, synthesis and structure relationships of new N,N',N",N"'-tetrakis (omega-amino alkyl) tetraazamacrocycles.
abstract: A number of N,N',N",N"'-tetrakis (omega-aminoalkyl) tetraazamacrocycles and related compounds were synthesized and evaluated for their inhibitory effects on human immunodeficiency virus type 1 (HIV-1) and duck hepatitis B virus (DHBV) replication. The activity of these compounds was found to be highly dependent upon structural features: (i) the length of the alkyl linker connecting the nitrogen atoms of the macrocyclic ring to the exocyclic nitrogen atoms of the terminal amino groups (five methylenes favoured antiviral activity); (ii) substitution of the terminal amino groups of the linker reduced antiviral activity; and (iii) the size of the tetraazamacrocyclic ring (14 or 15 atoms) did not markedly affect the antiviral activity. Some analogues were potent inhibitors of HIV-1 replication, with anti-HIV activity similar to that of biscyclam (JM 2763). In contrast, other analogues were found to be highly toxic in duck hepatocyte primary culture, the 2.2.15 cell line and to a lesser extent in MT-4 cells. Structural parameters, macrocyclic ring size and metal-chelating ability have been used to develop a structure-activity relationship model in order to aid the design of antiviral molecules derived from N,N',N",N"'-tetrakis (omega-aminoalkyl) tetraazamacrocycles.
authors.affiliation: Laboratoire de Chimie Biomoléculaire, Faculté des Sciences de Luminy, Marseille, France.
authors.forename: C
authors.initials: C
authors.lastname: Trabaud
authors.forename: J
authors.initials: J
authors.lastname: Dessolin
authors.forename: M
authors.initials: M
authors.lastname: Camplo
authors.forename: O
authors.initials: O
authors.lastname: Hantz
authors.forename: F
authors.initials: F
authors.lastname: Zoulim
authors.forename: C
authors.initials: C
authors.lastname: Borel
authors.forename: M
authors.initials: M
authors.lastname: Meyer
authors.forename: G
authors.initials: G
authors.lastname: Pepe
authors.forename: J C
authors.initials: JC
authors.lastname: Chermann
authors.forename: J L
authors.initials: JL
authors.lastname: Kraus
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D002478:Cells, Cultured; D004279:DNA, Viral / Q000032:analysis; D015195:Drug Design; D004372:Ducks; D015497:HIV-1 / Q000187:drug effects / Q000502:physiology; D015611:Hepatitis B Virus, Duck / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D001372:Aza Compounds; D004279:DNA, Viral