title: Single radiofrequency application to cure atrioventricular nodal reentry: arguments for the slow pathway origin of the high-low frequency slow potentials.
abstract: BACKGROUND
  High-low frequency slow potentials are thought to be related to the slow AV pathway conduction. Their use was proposed to guide radiofrequency (RF) ablation of atrioventricular nodal reentrant tachycardia (AVNRT). The present study was designed to determine the prospective value of these high-low frequency slow potentials to guide AVNRT ablation using a single RF application. Single RF application could indeed reduce the size of the lesion created in the viciny of the specialized AV conduction system and shorten the radiation exposure and the overall duration of the procedure.
  
  
  RESULTS
  Forty-one patients (14 men, 27 women, 45 +/- 16 years old) with AVNRT underwent slow pathway RF ablation guided by high-low frequency slow potentials. High-low frequency slow potentials were found in all patients along the tricuspid annulus and above the coronary sinus. Ablation was always performed in the posterior part of Koch's triangle. The mean A/V amplitude ratio of the successful site was 0.43 +/- 0.59. In 32 patients (78%) AVNRT was no longer inducible after a single RF application. Procedure and radiation times were 35 +/- 31 and 13 +/- 12 min respectively. Five patients required 2, 3 patients 3, and 1 patient 6 RF applications. The mean number of RF applications was 1.4 +/- 0.9 (median = 1). In the 32 patients who required only one RF application, 24 (75%) had an obvious dual AV nodal pathways with a jump before ablation, which completely disappeared in 18 of them (75%) after ablation. In the 6 remaining patients, who still had a jump after 1 RF application, there was no significant change in either conduction times or refractory periods concerning both the anterograde and retrograde AV conduction. No patient had PR interval purlongation. After a mean follow up of 11 +/- 5 months, recurrence was observed in a single patient who received 2 discontinued RF applications.
  
  
  CONCLUSIONS
  Catheter-mediated ablation of AVNRT using high-low frequency slow potentials to localize the slow AV pathway is feasible and safe. Using this technique, a single RF application was successfull in 78% of patients, and slow pathway characteristics were completely eliminated in 75% of patients. The radiation time and the procedure duration were short. This suggest that, in patients with AVNRT, the choice of an appropriate RF target can reduce procedural duration.
authors.affiliation: Cardiology A Department, University of Lille, France. dklug@chru-lille.fr
authors.forename: D
authors.initials: D
authors.lastname: Klug
authors.forename: D
authors.initials: D
authors.lastname: Lacroix
authors.forename: P
authors.initials: P
authors.lastname: Le Franc
authors.forename: Y
authors.initials: Y
authors.lastname: Ben Ameur
authors.forename: C
authors.initials: C
authors.lastname: Kouakam
authors.forename: S
authors.initials: S
authors.lastname: Kacet
authors.forename: J
authors.initials: J
authors.lastname: Lekieffre
mesh_terms: D000200:Action Potentials / Q000502:physiology; D001283:Atrioventricular Node / Q000503:physiopathology / Q000601:surgery; D017115:Catheter Ablation / Q000379:methods*; D003331:Coronary Vessels / Q000503:physiopathology; D004562:Electrocardiography / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012032:Refractory Period, Electrophysiological / Q000502:physiology; D013611:Tachycardia, Atrioventricular Nodal Reentry / Q000503:physiopathology / Q000601:surgery*; D013997:Time Factors; D014261:Tricuspid Valve / Q000503:physiopathology