5300 years ago, the Ice Man used natural laxatives and antibiotics.
Capasso
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D000900:Anti-Bacterial Agents / Q000266:history*; D002400:Cathartics / Q000266:history*; D049690:History, Ancient; D006801:Humans; D008297:Male; D009106:Mummies; D008517:Phytotherapy / Q000266:history*
D000900:Anti-Bacterial Agents; D002400:Cathartics