[Treatment of multiple sclerosis--2. Application of a new immunological basic research is close].
Based on continuous advances in our knowledge of the pathophysiological mechanisms involved in the development of multiple sclerosis and other putatively autoimmune diseases, several new immunological treatment strategies are currently being tested in different parts of the world. In principle, these strategies are designed to interfere with three steps in the presumed pathogenic immunological process: inhibition of lymphocyte recruitment to inflammatory foci in the central nervous system; blocking of antigen-specific activation; and interference with immunological effector mechanisms. Preliminary results are available for some of these treatment strategies.
Svenningsson
A
A
Neurologiska kliniken, Karolinska sjukhuset, Stockholm.
Andersson
M
M
Olsson
T
T
D000276:Adjuvants, Immunologic; D000818:Animals; D000938:Antigen-Presenting Cells / Q000187:drug effects; D002490:Central Nervous System / Q000276:immunology; D016207:Cytokines / Q000378:metabolism; D006680:HLA Antigens; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007167:Immunotherapy / Q000379:methods*; D016899:Interferon-beta / Q000627:therapeutic use; D008285:Major Histocompatibility Complex; D009103:Multiple Sclerosis / Q000276:immunology* / Q000628:therapy; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D000276:Adjuvants, Immunologic; D016207:Cytokines; D006680:HLA Antigens; D007166:Immunosuppressive Agents; D016899:Interferon-beta
Behandling av multipel skleros--2. Applikation av ny immunologisk grundforskning inom räckhåll.