title: Magnetic fields increase cell survival by inhibiting apoptosis via modulation of Ca2+ influx.
abstract: Static magnetic fields with intensities starting from 6 gauss (6x10(-4) tesla, T) were found to decrease in an intensity-dependent fashion, reaching a plateau at 6 x 10(-3) T, the extent of cell death by apoptosis induced by several agents in different human cell systems. This is not due to a change in the mode of cell death (i.e., to necrosis) or to a delay of the process itself; rather, the presence of magnetic fields allows the indefinite survival and replication of the cells hit by apoptogenic agents. The protective effect was found to be mediated by the ability of the fields to enhance Ca2+ influx from the extracellular medium; accordingly, it was limited to those cell systems where Ca2+ influx was shown to have an antiapoptotic effect. Magnetic fields thus might interfere with human health by altering/restoring the equilibrium between cell death and proliferation; indeed, the rescue of damaged cells may be the mechanism explaining why magnetic fields that are not mutagenic per se are often able to increase mutation and tumor frequencies.
authors.affiliation: Dipartimento di Biologia, Università di Roma 'Tor Vergata', via della Ricerca Scientifica, 00133, Rome, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Fanelli
authors.forename: S
authors.initials: S
authors.lastname: Coppola
authors.forename: R
authors.initials: R
authors.lastname: Barone
authors.forename: C
authors.initials: C
authors.lastname: Colussi
authors.forename: G
authors.initials: G
authors.lastname: Gualandi
authors.forename: P
authors.initials: P
authors.lastname: Volpe
authors.forename: L
authors.initials: L
authors.lastname: Ghibelli
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004574:Electromagnetic Fields; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005047:Etoposide / Q000494:pharmacology; D006801:Humans; D015759:Ionomycin / Q000494:pharmacology; D051381:Rats; D019284:Thapsigargin / Q000494:pharmacology; D013950:Thymus Gland / Q000166:cytology; D059005:Topoisomerase II Inhibitors; D020298:U937 Cells
chemical_list: D004791:Enzyme Inhibitors; D059005:Topoisomerase II Inhibitors; D015759:Ionomycin; D019284:Thapsigargin; D005047:Etoposide; D002118:Calcium