Adenosine deaminase inhibitors. Synthesis and biological evaluation of aralkyladenines (ARADS).
Several 9-aralkyladenines have been prepared and their ADA inhibitory activity was determined. A minimum of two carbon atoms separating the aromatic ring from the adenine-bearing carbon (C3') was found essential for potent activity.
Curtis
M A
MA
Department of Biomedical Sciences, University of Rhode Island, Kingston 02881-0809, USA.
Varkhedkar
V
V
Pragnacharyulu
P V
PV
Abushanab
E
E
D000225:Adenine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology*; D058892:Adenosine Deaminase Inhibitors; D004341:Drug Evaluation; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*
D058892:Adenosine Deaminase Inhibitors; D004791:Enzyme Inhibitors; D000225:Adenine