A highly polymorphic CA repeat marker at the human tumor necrosis factor alpha (TNFA alpha) locus.
Tumor necrosis factor alpha (TNF alpha) in activated monocytes exerts cytotoxic activity and has a variety of other biological effects. We isolated a polymorphic dinucleotide (CA) repeat sequence from a genomic clone containing the gene located at 6p21.3. High heterozygosity (0.80) makes this polymorphism a useful marker in the genetic study of disorders affecting immunological response and cell differentiation.
Tsukamoto
K
K
Department of Molecular Biology, Nippon Medical School, Kawasaki, Japan.
Ohta
N
N
Shirai
Y
Y
Emi
M
M
D000483:Alleles; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6; D018900:Dinucleotide Repeats; D005787:Gene Frequency; D005819:Genetic Markers; D006801:Humans; D011110:Polymorphism, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D005819:Genetic Markers; D014409:Tumor Necrosis Factor-alpha