title: Total synthesis of fentanyl.
abstract: Fentanyl of a potent anilidopiperidine analgesic has been synthesized from a simple phenylethylamine by four step sequence. The key part of this synthesis involves an efficient construction of phenylethylpiperidone skeleton via aminomethano desilyltion-cyclization followed by Swern oxidation.
authors.affiliation: College of Pharmacy, Seoul National University, Korea.
authors.forename: Y G
authors.initials: YG
authors.lastname: Suh
authors.forename: K H
authors.initials: KH
authors.lastname: Cho
authors.forename: D Y
authors.initials: DY
authors.lastname: Shin
mesh_terms: D000701:Analgesics, Opioid / Q000138:chemical synthesis*; D003500:Cyclization; D005283:Fentanyl / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D010084:Oxidation-Reduction; D010880:Piperidines / Q000737:chemistry
chemical_list: D000701:Analgesics, Opioid; D007202:Indicators and Reagents; D010880:Piperidines; D005283:Fentanyl