title: Descriptive epidemiology of vulvar and vaginal cancers in Vaud, Switzerland, 1974-1994.
abstract: BACKGROUND
  To analyse trends in incidence, survival and risk of second neoplasms following vaginal and vulvar cancers using data collected by the Swiss Cancer Registry of Vaud over the 21-year period 1974-1994.
  
  
  METHODS
  Subjects were 257 vulvo-vaginal cancers. Of these, 69 were vaginal, 153 vulvar cancers, and 35 non-specified lower genital tract neoplasms; 94 in situ neoplasms were also registered (85 for the vulva).
  
  
  RESULTS
  Invasive vaginal cancer incidence decreased from 0.8 in 1974-1984 to 0.4/100,000 women in 1985-1994, while invasive vulvar cancer incidence remained approximately stable around 1.2/100,000 (world standard); incidence of in situ vulvar cancer increased from 0.8 to 1.3/100,000, the rise being larger in younger women. Significant excesses for second primary neoplasms were observed for pro-pharyngeal and lung cancer, and for non-melanomatous skin neoplasms, as well as for invasive vulvar cancers following in situ cancers.
  
  
  CONCLUSIONS
  This population-based dataset confirms that the incidence of in situ vulvar (but not invasive vulvar or vaginal cancer) has been increasing over the last 20 years. The excess second primary neoplasms supports the hypotheses that human papillomavirus and cigarette smoking are related to vulvo-vaginal neoplasms.
authors.affiliation: Institut universitaire de médecine sociale et préventive, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland. fabio.levi@inst.hospvd.ch
authors.forename: F
authors.initials: F
authors.lastname: Levi
authors.forename: L
authors.initials: L
authors.lastname: Randimbison
authors.forename: C
authors.initials: C
authors.lastname: La Vecchia
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D012042:Registries; D012307:Risk Factors; D016019:Survival Analysis; D013557:Switzerland / Q000453:epidemiology; D014625:Vaginal Neoplasms / Q000453:epidemiology*; D014846:Vulvar Neoplasms / Q000453:epidemiology*