title: Are there cognitive subtypes in adult attention deficit/hyperactivity disorder?
abstract: There has been increasing knowledge of the treatment, diagnosis, and demographics of adults with residual attention deficit/hyperactivity disorder (ADHD). However, less is known about the neuropsychological functioning in adults with residual ADHD. In comparing the clinical neuropsychological test performance of a group of adult clinic patients with residual ADHD (N = 30) with that of normal controls (N = 10), we found the patients performed worse on the Trail Making Test, a visual continuous performance test, and the "Brown-Peterson" Auditory Consonant Trigrams Test, but not on any other neuropsychological measures. This pattern indicated a deficit in the area of executive control type functioning, a functional deficit that could be linked to dysregulation of frontal lobe brain systems. Of equal interest was that patients diagnosed with ADHD/hyperactive impulsive type (ADHD+) and patients diagnosed with ADHD/inattentive type (ADHD-) had different types of executive system deficits. ADHD+ was associated with relative deficiency on the Wisconsin Card Sorting Test. ADHD- was associated with relative deficiency on the "Brown-Peterson" Auditory Consonant Trigrams Test, a measure of working memory, as well as less olfactory identification on a smell identification test. The data are discussed in terms of recent localization theories of frontal lobe function. The preliminary data suggest that the different cognitive weaknesses of ADD subtypes may be linked to dysregulation of separate frontal brain regions and/or neurotransmitter systems.
authors.affiliation: Department of Psychiatry, Boston Department of Veterans Affairs Medical Center and Boston University School of Medicine, Massachusetts, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Gansler
authors.forename: R
authors.initials: R
authors.lastname: Fucetola
authors.forename: M
authors.initials: M
authors.lastname: Krengel
authors.forename: S
authors.initials: S
authors.lastname: Stetson
authors.forename: R
authors.initials: R
authors.lastname: Zimering
authors.forename: C
authors.initials: C
authors.lastname: Makary
mesh_terms: D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000145:classification / Q000175:diagnosis* / Q000503:physiopathology; D003072:Cognition Disorders / Q000145:classification / Q000175:diagnosis; D005625:Frontal Lobe / Q000503:physiopathology; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008568:Memory / Q000502:physiology; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D018377:Neurotransmitter Agents / Q000502:physiology; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D012903:Smell / Q000502:physiology; D014145:Trail Making Test / Q000706:statistics & numerical data
chemical_list: D018377:Neurotransmitter Agents