Novel D-ring analogues of podophyllotoxin as potent anti-cancer agents.
Several D-ring modified analogues of podophyllotoxin were prepared viz semi-synthesis starting from naturally occurring podophyllotoxin and determined their in vitro anti-cancer activity. Most of the analogues have shown good activity towards human cancer cell lines.
Subrahmanyam
D
D
Natural Products Division, Dr. Reddy's Research Foundation, Miyapur, Hyderabad, India.
Renuka
B
B
Rao
C V
CV
Sagar
P S
PS
Deevi
D S
DS
Babu
J M
JM
Vyas
K
K
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D011034:Podophyllotoxin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D011034:Podophyllotoxin