title: Construction of a family of biphenyl combinatorial libraries: structure-activity studies utilizing libraries of mixtures.
abstract: A set of biphenyl aminoacid building blocks has been synthesized. These were used to construct partially-peptidic combinatorial libraries as equimolar multi-component samples. Activity of members of this library as vitronectin receptor antagonists is described, together with SAR studies of the most active members. These studies illustrate several important features of combinatorial libraries.
authors.affiliation: Schering-Plough Research Institute, Kenilworth, NJ 07033-0539, USA.
authors.forename: B R
authors.initials: BR
authors.lastname: Neustadt
authors.forename: E M
authors.initials: EM
authors.lastname: Smith
authors.forename: N
authors.initials: N
authors.lastname: Lindo
authors.forename: T
authors.initials: T
authors.lastname: Nechuta
authors.forename: A
authors.initials: A
authors.lastname: Bronnenkant
authors.forename: A
authors.initials: A
authors.lastname: Wu
authors.forename: L
authors.initials: L
authors.lastname: Armstrong
authors.forename: C
authors.initials: C
authors.lastname: Kumar
mesh_terms: D001713:Biphenyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D019992:Databases as Topic; D015195:Drug Design; D007536:Isomerism; D007700:Kinetics; D008968:Molecular Conformation; D015394:Molecular Structure; D019030:Receptors, Vitronectin / Q000187:drug effects / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D001713:Biphenyl Compounds; D019030:Receptors, Vitronectin