System B0,(+)-mediated regulation of lysine transport in Caco-2 human intestinal cells.
We investigated whether lysine transport would be subject to adaptive regulation in Caco-2 human intestinal cells. The activity of Lys transport in Caco-2 cells decreased with increasing incubation time with 10 mM Lys. Among the two systems involved in Lys transport, the system b0,+ component was greatly decreased by incubating cells with 10 mM Lys, whereas the system y+ component did not change. These results suggest that system b0,+ mainly contributes to the adaptive regulation of Lys transport in Caco-2 cells.
Satsu
H
H
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, Japan.
Watanabe
H
H
Arai
S
S
Shimizu
M
M
D026905:Amino Acid Transport Systems; D001692:Biological Transport; D018938:Caco-2 Cells; D002352:Carrier Proteins / Q000378:metabolism*; D015536:Down-Regulation; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D008239:Lysine / Q000378:metabolism*
D026905:Amino Acid Transport Systems; D002352:Carrier Proteins; D008239:Lysine