title: [Clinical value of endoscopic ultrasound-guided transesophageal fine needle puncture of mediastinal lesions].
abstract: OBJECTIVE
  As the mediastinum has been a region difficult to access for biopsy, mediastinoscopy has been required in most cases. In a prospective study the value of transoesophageal endoscopic ultrasound (TEUS) guided aspiration biopsy was assessed as an alternative.
  
  
  METHODS
  TEUS-guided fine-needle aspirations were performed between May 1995 and March 1998 in 35 patients with mediastinal space-occupying lesions. In all cases the conventional endoscopic method or percutaneous puncture-sonography had been impossible or had failed. In one patient it had been performed after a negative mediastinoscopy.
  
  
  RESULTS
  In 34 patients (97%) the aspirated tissue cylinder could be evaluated histologically. There were no complications. Malignancy was demonstrated in 24 patients, and there were one case each of sarcoidosis, silicoanthracosis and two cases of retrosternal goitre. In four of seven patients the negative preoperative diagnosis was confirmed at operation or by follow-up. There were two false-negative results and in one patient there has been no definitive diagnosis. The accuracy of the method was thus 91.4%, the positive predictive value for malignancy 88.9% and the negative predictive value for malignancy 72.7%. Ultrasound alone was a poor predictor of malignancy in lymph node enlargement.
  
  
  CONCLUSIONS
  TEUS-guided fine-needle aspiration of space-occupying mediastinal lesions is an effective and low-risk method that can in selected cases shorten the diagnostic process and avoid methods that are expensive or lead to complications such as transpulmonary biopsy guided by computed tomography or mediastinoscopy.
authors.affiliation: Medizinische Klinik A, Klinikum Wuppertal, Universität Witten-Herdecke. jjanssen@klinikum-wuppertal.de
authors.forename: J
authors.initials: J
authors.lastname: Janssen
authors.forename: W
authors.initials: W
authors.lastname: Johanns
authors.forename: W
authors.initials: W
authors.lastname: Luis
authors.forename: L
authors.initials: L
authors.lastname: Greiner
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000874:Anthracosilicosis / Q000473:pathology; D001707:Biopsy, Needle / Q000379:methods; D003937:Diagnosis, Differential; D019160:Endosonography; D005260:Female; D006045:Goiter, Substernal / Q000473:pathology; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008477:Mediastinal Diseases / Q000473:pathology; D008479:Mediastinal Neoplasms / Q000473:pathology*; D008481:Mediastinoscopy; D008482:Mediastinum / Q000473:pathology*; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012507:Sarcoidosis / Q000473:pathology
vernacular_title: Zum klinischen Stellenwert der endosonographisch gesteuerten transösophagealen Feinnadelpunktion von Mediastinalprozessen.