Verification of immunosuppression in chicks caused by Cryptosporidium baileyi infection using Brucella abortus strain 1119-3.
Humoral immune response of young chicks to Brucella abortus strain 1119-3 inoculation was monitored to verify the degree of immunosuppression caused by infection with Cryptosporidium baileyi. Young chicks (2-day-old) were orally inoculated each with 2 x 10(6) oocysts of C. baileyi, and then injected intramuscularly with 0.3 ml B. abortus strain 1119-3 containing 1 x 10(9) living organisms on day 14 postinoculation (PI). Serum samples were tested by plate agglutination test on day 17 PI onwards at an interval of 3-6 days over a period of 36 days. Infected chicks with the coccidium showed significantly lower antibody titers than those of uninfected controls (P < 0.05). These findings document that C. baileyi infection in early life stage may predispose chicks easily to other potential poultry diseases.
Rhee
J K
JK
Bio-Safety Research Institute, Veterinary School, Chonbuk National University, Chonju, Korea. jkr@moak.chonbuk.ac.kr
Yang
H J
HJ
Kim
H C
HC
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D000917:Antibody Formation; D002003:Brucella abortus / Q000276:immunology*; D002645:Chickens; D003457:Cryptosporidiosis / Q000276:immunology*; D007108:Immune Tolerance
D000907:Antibodies, Bacterial