title: [A biocompatibility study and the effects of slow-release antibiotic materials in the treatment of periodontal disease. I. The biocompatibility of cellulose acetate charged with 25% tetracycline hydrochloride. A clinical and scanning microscopic study of a case].
abstract: A clinical and microscopical (SEM) investigation has been carried out on the biocompatibility of cellulose acetate fiber tetracycline with 25% of tetracycline hydrochloride (Actisite R). A subject with advanced periodontal disease was selected and a pocket of 8 mm of PD was chosen. A segment of fiber was inserted into the pocket for 8 days. After removal, PD and GI clinical parameters were detected and the fiber removed was analyzed at the scanning electronic microscope. The results showed clinical signs of inflammation after removal of fiber. SEM analysis showed macrophagic reaction, a typical sign of inflammatory response to material. The study suggests the need of more biocompatible materials, easier to use as delivery system of antibiotics in the treatment of periodontal disease.
authors.affiliation: Istituto di Clinica Odontoiatrica e Stomatologia, Seconda Università degli Studi, Napoli.
authors.forename: G
authors.initials: G
authors.lastname: Aronna
authors.forename: A
authors.initials: A
authors.lastname: De Rosa
authors.forename: F
authors.initials: F
authors.lastname: Rosso
authors.forename: S
authors.initials: S
authors.lastname: Margarucci
authors.forename: F
authors.initials: F
authors.lastname: Caruso
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001672:Biocompatible Materials / Q000008:administration & dosage*; D002482:Cellulose / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D016503:Drug Delivery Systems; D004341:Drug Evaluation; D006801:Humans; D008297:Male; D008855:Microscopy, Electron, Scanning; D010514:Periodontal Pocket / Q000188:drug therapy* / Q000473:pathology; D013752:Tetracycline / Q000008:administration & dosage*
chemical_list: C116585:Actisite; D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D004338:Drug Combinations; C005062:acetylcellulose; D002482:Cellulose; D013752:Tetracycline
vernacular_title: Studio sulla biocompatibilità e gli effetti di alcuni materiali a lento rilascio di antibiotico nel trattamento della malattia parodontale. Nota I. Biocompatibilità dell'acetato di cellulosa caricato con il 25% di tetraciclina cloridrato. Studio clinico e al microscopio a scansione di un caso.