title: Evaluation of dosage forms. IV. Studies on commercial phenylbutazone tablet dosage forms.
abstract: In order to determine the feasibility of dissolution-dialysis as a suitable technique for in vitro evaluation, studies on commercial phenylbutazone tablets were carried out. Although disintegration time and dissolution parameters did not give a true indication of bioavailability, an excellent correlation was obtained between the dialysis rate constant (K) and various pharmacokinetic parameters obtained from bioavailability studies on human volunteers.
authors.affiliation: Department of Pharmaceutical Sciences, Birla Institute of Technology, Ranchi, India.
authors.forename: B
authors.initials: B
authors.lastname: Razdan
authors.forename: A R
authors.initials: AR
authors.lastname: Paradkar
mesh_terms: D000328:Adult; D001682:Biological Availability; D004304:Dosage Forms; D005069:Evaluation Studies as Topic; D006801:Humans; D016014:Linear Models; D008297:Male; D010653:Phenylbutazone / Q000008:administration & dosage* / Q000493:pharmacokinetics; D012016:Reference Values; D012995:Solubility; D013607:Tablets
chemical_list: D004304:Dosage Forms; D013607:Tablets; D010653:Phenylbutazone