title: A new strong inhibitor of beta-mannosidase.
abstract: N-phenyl-carbamate of D-mannonohydroxymolactone (I) was synthesized from mannose and was shown to be the best competitive inhibitor of beta-mannosidase so far reported (Ki = 25 nM).
authors.affiliation: S.E.S.N.A.B., Pole Sciences et Technologie, Université de La Rochelle. therisod@icmo.u-psud.fr
authors.forename: H
authors.initials: H
authors.lastname: Therisod
authors.forename: Y
authors.initials: Y
authors.lastname: Letourneux
authors.forename: M
authors.initials: M
authors.lastname: Therisod
mesh_terms: D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006860:Hydrogen Bonding; D008361:Mannosidases / Q000037:antagonists & inhibitors*; D044902:beta-Mannosidase
chemical_list: D004791:Enzyme Inhibitors; D008361:Mannosidases; D044902:beta-Mannosidase