[The effect of dexamethasone on the reactions of the blood system in inflammation].
On the model of carrageenan-induced acute aseptic peritonitis in rats it is shown that under influence of dexamethasone granulomonocytopoiesis, efflux of leukocytes to blood and their accumulation in inflammatory focus are increased and earlier completion of leukocytic reaction is observed and that the antiinflammatory effect of dexamethasone is mainly realized by the way of increasing of defence-adaptative blood system's reactions.
Klymenko
M O
MO
Kharkov Medical University, Ministry of Public Health of Ukraine.
Shevchenko
O M
OM
D000208:Acute Disease; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001772:Blood Cell Count / Q000187:drug effects; D001773:Blood Cells / Q000187:drug effects*; D002351:Carrageenan; D003907:Dexamethasone / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D008297:Male; D010538:Peritonitis / Q000097:blood* / Q000139:chemically induced / Q000188:drug therapy; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D003907:Dexamethasone; D002351:Carrageenan
Vplyv deksametazonu na reaktsiï systemy krovi pry zapalenni.