title: Efficacy of laser-assisted uvulopalatoplasty in obstructive sleep apnea.
abstract: Laser-assisted uvulopalatoplasty (LAUP) enlarges the oropharyngeal airway by reshaping the uvula, soft palate, and tonsillar pillars. In contrast to a uvulopalatopharyngoplasty performed in the operating room, LAUP is staged over several office visits, is less costly, is bloodless, and is not associated with velopharyngeal insufficiency or stenosis. Previous studies have documented the efficacy of LAUP in the treatment of snoring. We explore the efficacy of LAUP in the treatment of obstructive sleep apnea. Forty-eight patients comprised the study group. Each patient snored, exhibited >50% palatal collapse on Müller's maneuver, and had nocturnal polysomnography showing a respiratory disturbance index (RDI) >10. Each patient underwent LAUP until he or she reported that snoring had ceased. Of the 29 patients who underwent post-LAUP nocturnal polysomnography, 7 had RDIs <10, oxygen saturation >86%, and no cardiac arrhythmias. LAUP reduced RDI to <10 in patients with pre-LAUP apnea indexes <3 (P = 0.05) or pre-LAUP RDIs <30 (P = 0.01). The following variables did not correlate with the success of LAUP in treating obstructive sleep apnea: age, sex, pre-LAUP weight, pre-LAUP body mass index, perioperative weight change, perioperative body mass index change, pre-LAUP snoring, and post-LAUP snoring. We conclude that LAUP is an effective means of treating patients with RDIs <30.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
authors.forename: E A
authors.initials: EA
authors.lastname: Pribitkin
authors.forename: S L
authors.initials: SL
authors.lastname: Schutte
authors.forename: W M
authors.initials: WM
authors.lastname: Keane
authors.forename: V
authors.initials: V
authors.lastname: Mao
authors.forename: J R
authors.initials: JR
authors.lastname: Cater
authors.forename: K
authors.initials: K
authors.lastname: Doghramji
authors.forename: J M
authors.initials: JM
authors.lastname: Youakim
authors.forename: M R
authors.initials: MR
authors.lastname: Rosen
authors.forename: W
authors.initials: W
authors.lastname: Breuninger
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D010159:Palate / Q000601:surgery*; D017286:Polysomnography; D012891:Sleep Apnea Syndromes / Q000601:surgery*; D016896:Treatment Outcome; D014609:Uvula / Q000601:surgery*