title: [Hybrid tumor of the penis: is this denomination correct?].
abstract: OBJECTIVE
  Few cases of verrucous carcinoma of the penis with foci of invasive squamous cell carcinoma have been reported and denominated "hybrid tumors". The accuracy of this term is discussed in this paper.
  
  
  RESULTS
  A huge penile mass in a patient that had undergone three previous operations for lesions diagnosed as verrucous carcinoma is reported. Partial penectomy was performed. Histological examination showed a very well-differentiated squamous cell carcinoma. PCR (polymerase chain reaction) did not detect any type of human papillomavirus (HPV) in the tumor.
  
  
  CONCLUSIONS
  Verrucous carcinoma is a strictly-defined lesion with a different biological behaviour from that of squamous carcinoma. Preoperative deep biopsy may miss the squamous cell carcinoma. Definitive diagnosis can only be achieved by histological examination of the surgical specimen. In future, DNA studies could possibly support preoperative diagnosis of this lesion.
authors.affiliation: Servicio de Urología, Hospital Ramón y Cajal, Madrid, España.
authors.forename: L M
authors.initials: LM
authors.lastname: Clemente Ramos
authors.forename: R
authors.initials: R
authors.lastname: García González
authors.forename: F J
authors.initials: FJ
authors.lastname: Burgos Revilla
authors.forename: E
authors.initials: E
authors.lastname: Maganto Pavón
authors.forename: S
authors.initials: S
authors.lastname: Fernández Cañadas
authors.forename: J
authors.initials: J
authors.lastname: Blázquez Gómez
authors.forename: C
authors.initials: C
authors.lastname: Carrera Puerta
authors.forename: A
authors.initials: A
authors.lastname: Escudero Barrilero
mesh_terms: D018289:Carcinoma, Verrucous / Q000473:pathology*; D003218:Condylomata Acuminata / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008875:Middle Aged; D010412:Penile Neoplasms / Q000473:pathology*; D009626:Terminology as Topic
vernacular_title: Tumor híbrido de pene: es correcta dicha denominación?