title: Synthesis and biological evaluation of 3-arylisoquinolines as antitumor agents.
abstract: To investigate the structure-activity relationship of 7,8-dimethoxy-2- methyl-3-(4,5-methylenedioxy-2-vinylphenyl)isoquinolin-1(2H) -one 2, diverse substituted 3-arylisoquinolines were synthesized and tested in vitro antitumor activity against five human tumor cell lines. The results showed a broad antitumor spectrum for a series of 3-arylisoquinolines.
authors.affiliation: College of Pharmacy, Chonnam National University, Buk-gu, Kwangju, Korea.
authors.forename: W J
authors.initials: WJ
authors.lastname: Cho
authors.forename: M J
authors.initials: MJ
authors.lastname: Park
authors.forename: B H
authors.initials: BH
authors.lastname: Chung
authors.forename: C O
authors.initials: CO
authors.lastname: Lee
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D007546:Isoquinolines