[Effects of sevoflurane on contractility of isolated thoracic aorta rings in rabbits].
The objective of this paper was to observe the effects of sevoflurane on isolated rabbit aortic rings and the mechanisms of the effects. Twenty-four vascular rings collected from different New Zealand rabbits were randomly divided into 4 groups: Group 1 endothelium-inact rings; Group 2 endothelium-denuded rings; Group 3 endothelium-intact rings plus indomethacin; Group 4 endothelium-denuded rings plus indomethacin. When stable active tension produced by phenylephrine (1 x 10(-6) mol.L-1) was obtained, sevoflurane was added into the tissue bath. The anesthetic gas was increased in 0.5% increments every 10 min until the 4% of sevflurane after which 5% was administered. In rings of Group 3 and Group 4, indomethacin (2.8 x 10(-5) mol.L-1) was added to the bath 10 min before the addition of sevoflurane. The results showed that sevoflurane relaxed all groups of rings dose-dependently and this action was non-endothelium dependent and indomethacin had no effect on it. It suggests that sevoflurane relaxes peripheral vessels perhaps by affecting vascular muscle directly.
Xu
J
J
Department of Anesthesiology, Second Affiliated Hospital, Hunan Medical University, Changsha.
Cheng
Q
Q
Niu
X
X
D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D066298:In Vitro Techniques; D008738:Methyl Ethers / Q000494:pharmacology*; D009126:Muscle Relaxation / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D011817:Rabbits; D000077149:Sevoflurane; D014665:Vasodilator Agents / Q000494:pharmacology*
D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D014665:Vasodilator Agents; D000077149:Sevoflurane