Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists.
In a 3-oxo-1,4-benzodiazepine-2-acetic acid series of vitronectin receptor (alpha v beta 3) antagonists containing a benzimidazole as a novel arginine mimetic, we examined the effects of benzimidazole modifications and amide substitutions on both activity and pharmacokinetics.
Keenan
R M
RM
Research & Development Division, SmithKline Beecham Pharmaceuticals, Collegeville, PA 19426-0989, USA.
Miller
W H
WH
Lago
M A
MA
Ali
F E
FE
Bondinell
W E
WE
Callahan
J F
JF
Calvo
R R
RR
Cousins
R D
RD
Hwang
S M
SM
Jakas
D R
DR
Ku
T W
TW
Kwon
C
C
Nguyen
T T
TT
Reader
V A
VA
Rieman
D J
DJ
Ross
S T
ST
Takata
D T
DT
Uzinskas
I N
IN
Yuan
C C
CC
Smith
B R
BR
D001120:Arginine; D001562:Benzimidazoles / Q000494:pharmacology*; D001569:Benzodiazepines / Q000494:pharmacology*; D019030:Receptors, Vitronectin / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
D001562:Benzimidazoles; D019030:Receptors, Vitronectin; D001569:Benzodiazepines; D001120:Arginine