Dynamics of human immunodeficiency virus type 1 replication in vertically infected infants.
Plasma human immunodeficiency virus type 1 (HIV-1) turnover and kinetics were studied in children aged 15 days to 2 years following the initiation of a triple antiretroviral drug regimen consisting of zidovudine, lamivudine, and nevirapine. HIV-1 turnover was at least as rapid as that previously described in adults; turnover rates were more rapid in infants and children aged 3 months to 2 years than in infants less than 3 months of age. These data confirm the central role of HIV-1 replication in the pathogenesis of vertical HIV-1 infection and reinforce the importance of early, potent combination therapies for the long-term control of HIV-1 replication.
Luzuriaga
K
K
Department of Pediatrics, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Boston, Massachusetts, USA. katherine.luzuriaga@ummed.edu
Wu
H
H
McManus
M
M
Britto
P
P
Borkowsky
W
W
Burchett
S
S
Smith
B
B
Mofenson
L
L
Sullivan
J L
JL
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy / Q000635:transmission / Q000821:virology*; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D014766:Viremia / Q000188:drug therapy / Q000821:virology*; D014779:Virus Replication
D019380:Anti-HIV Agents