[Use of blast transformation test with different tuberculin dilutions to evaluate functional activity and directivity vector of T-cell activation in patients with tuberculosis during chemotherapy].
The lymphocyte blast transformation test (LBTT) with three tuberculin dilutions was used to examine 190 patients with varying pulmonary tuberculosis activity, of them 63 patients received chemotherapy. According to the blast formation in the patients' cultured peripheral blood cells by three tuberculin dilutions, a correlation was found between the clinical manifestations of the process and the functional activity of T lymphocytes. Thus, the greatest percentage (500 TU) of blasts in LBTT per mean PPD dose was detectable in patients with low LBTT results by three tuberculin dilutions with positive dynamics during chemotherapy. With further positive dynamics, the proportion of blasts in the cultured peripheral blood cells was highest per high PPD doses (5000 TU). On the contrary, patients with progressive tuberculosis displayed a oppositely directed phasic pattern.
Karpov
A V
AV
Evdokimov
V N
VN
Illarionov
V A
VA
D000942:Antigens, Bacterial / Q000276:immunology; D000995:Antitubercular Agents / Q000627:therapeutic use*; D002478:Cells, Cultured / Q000187:drug effects; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D008213:Lymphocyte Activation; D018655:Lymphocyte Count; D009169:Mycobacterium tuberculosis / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D016896:Treatment Outcome; D014373:Tuberculin / Q000008:administration & dosage / Q000276:immunology; D014374:Tuberculin Test; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*
D000942:Antigens, Bacterial; D000995:Antitubercular Agents; D014373:Tuberculin
Reaktsiia blasttransformatsii limfotsitov s razlichnymi razvedeniiami tuberkulina dlia otsenki funktsional'noĭ aktivnosti i vektora napravlennosti aktivatsii T-kletochnogo immuniteta v protsesse khimioterapii u bol'nykh tuberkulezom.