title: In vitro activities of six new fluoroquinolones against Brucella melitensis.
abstract: We have tested the in vitro activities of eight fluoroquinolones against 160 Brucella melitensis strains. The most active was sitafloxacin (MIC at which 90% of the isolates are inhibited [MIC90], 0.12 microg/ml). In decreasing order, the activities (MIC90s) of the rest of the tested fluoroquinolones were as follows: levofloxacin, 0.5 microg/ml; ciprofloxacin, trovafloxacin, and moxifloxacin, 1 microg/ml; and ofloxacin, grepafloxacin, and gatifloxacin, 2 microg/ml.
authors.affiliation: Departamento de Microbiología y Parasitología, Hospital Universitario, Salamanca, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Trujillano-Martín
authors.forename: E
authors.initials: E
authors.lastname: García-Sánchez
authors.forename: I M
authors.initials: IM
authors.lastname: Martínez
authors.forename: M J
authors.initials: MJ
authors.lastname: Fresnadillo
authors.forename: J E
authors.initials: JE
authors.lastname: García-Sánchez
authors.forename: J A
authors.initials: JA
authors.lastname: García-Rodríguez
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D017347:Brucella melitensis / Q000187:drug effects* / Q000302:isolation & purification; D015169:Colony Count, Microbial; D024841:Fluoroquinolones
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones