Beta3-adrenergic receptor gene polymorphism is not associated with hypertension in NIDDM patients without nephropathy.
OBJECTIVE
We studied the relationship between a Trp64Arg mutation of beta3-adrenergic receptor gene and hypertension in Japanese NIDDM patients without nephropathy.


METHODS
Eighty-three Japanese NIDDM patients (46 men, 37 women, known duration of 12 [5-31], age of 55 [40-69] years, median and [range]) with normoalbuminuria and microalbuminuria were studied. The Trp64Arg mutation in the beta3-adrenergic receptor gene was determined by the PCR-RFLP method.


RESULTS
The frequency of the mutated allele was not greater in the hypertensive patients (18.2%, n=37) than in the normotensive (20.2%, n=46) patients. Genotypes with a mutate allele (i.e. Trp64/Arg64 + Arg64/Arg64) were observed in 23.5% in the hypertensive patients and in 35.7% in the normotensive patients, respectively. A similar finding in the allele frequency was observed when the analysis was made separately in the normoalbuminuric and microalbuminuric patients, respectively.


CONCLUSIONS
These results suggest that a Trp64Arg mutation in the beta3-adrenergic receptor gene is not associated with hypertension in Japanese NIDDM patients without nephropathy.
Baba
T
T
Department of Internal Medicine, Kitasato University School of Medicine, Japan. baba@yha.att.ne.jp
Nakajima
S
S
Yajima
Y
Y
D000328:Adult; D000368:Aged; D001120:Arginine / Q000235:genetics; D003062:Codon; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011943:Receptors, Adrenergic, beta / Q000235:genetics*; D014364:Tryptophan / Q000235:genetics
D003062:Codon; D011943:Receptors, Adrenergic, beta; D014364:Tryptophan; D001120:Arginine