title: Isolation and identification of inhibitory compounds on TNF-alpha production from Magnolia fargesii.
abstract: Three TNF alpha-inhibitory lignans were isolated from the flower buds of Magnolia fargesii through bioassay-guided isolation. They were identified as eudesmin, magnolin and lirioresinol-B dimethylether on the basis of their spectroscopic data. All three lignans showed inhibitory effects on TNF-alpha production in LPS-stimulated murine macrophage cell line, RAW264.7 and eudesmin showed the strongest activity (IC50 = 51 microM).
authors.affiliation: Research and Development Center, Daewoong Pharmaceutical Co., Sungnam, Korea.
authors.forename: S H
authors.initials: SH
authors.lastname: Chae
authors.forename: P S
authors.initials: PS
authors.lastname: Kim
authors.forename: J Y
authors.initials: JY
authors.lastname: Cho
authors.forename: J S
authors.initials: JS
authors.lastname: Park
authors.forename: J H
authors.initials: JH
authors.lastname: Lee
authors.forename: E S
authors.initials: ES
authors.lastname: Yoo
authors.forename: K U
authors.initials: KU
authors.lastname: Baik
authors.forename: J S
authors.initials: JS
authors.lastname: Lee
authors.forename: M H
authors.initials: MH
authors.lastname: Park
mesh_terms: D002460:Cell Line; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D006801:Humans; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000096:biosynthesis*
chemical_list: D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha