Efficient construction of 6-azasteroids: dual inhibitors of steroidal 5 alpha-reductase.
A new route to 17 beta-substituted-6-azaandrost-4-en-3-ones, potent dual inhibitors of type 1 and 2 steroidal 5 alpha-reductase, is described.
Sharp
M J
MJ
Chemical Development Department, Glaxo Wellcome Inc., Research Triangle Park, North Carolina 27709, USA.
Fang
F G
FG
D001372:Aza Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D042944:Cholestenone 5 alpha-Reductase; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D007527:Isoenzymes / Q000037:antagonists & inhibitors*; D010088:Oxidoreductases / Q000037:antagonists & inhibitors*; D013256:Steroids / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D001372:Aza Compounds; D004791:Enzyme Inhibitors; D007527:Isoenzymes; D013256:Steroids; D010088:Oxidoreductases; D042944:Cholestenone 5 alpha-Reductase