title: Novel alternative splicing in the 5' exon of the neurotrophin-3 gene.
abstract: The neurotrophin-3 (NT-3) gene has previously been reported to consist of three exons including two 5' short untranslated exons and a 3' long exon encoding the entire protein, and to give rise to two classes of transcripts by alternative splicing of the 5' exons to the 3' coding exon. In the present study, we demonstrated the presence of at least four new classes of transcripts of the NT-3 gene, in addition to the two known transcripts. The present finding proposes the further complexity of the regulational mechanism for NT-3 expression.
authors.affiliation: Laboratory of Health Science, School of Pharmaceutical Sciences, University of Shizuoka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Sekimoto
authors.forename: K
authors.initials: K
authors.lastname: Fukamachi
authors.forename: F
authors.initials: F
authors.lastname: Nemoto
authors.forename: S
authors.initials: S
authors.lastname: Miyata
authors.forename: M
authors.initials: M
authors.lastname: Degawa
authors.forename: E
authors.initials: E
authors.lastname: Senba
authors.forename: T
authors.initials: T
authors.lastname: Ueyama
authors.forename: K
authors.initials: K
authors.lastname: Nemoto
mesh_terms: D017398:Alternative Splicing / Q000502:physiology*; D000818:Animals; D003001:Cloning, Molecular; D017931:DNA Primers; D005091:Exons / Q000502:physiology*; D015870:Gene Expression / Q000502:physiology; D008297:Male; D008969:Molecular Sequence Data; D009414:Nerve Growth Factors / Q000235:genetics*; D018696:Neuroprotective Agents / Q000378:metabolism; D020933:Neurotrophin 3; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D011921:Rats, Inbred WKY; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017386:Sequence Homology, Amino Acid; D014158:Transcription, Genetic / Q000502:physiology
chemical_list: D017931:DNA Primers; D009414:Nerve Growth Factors; D018696:Neuroprotective Agents; D020933:Neurotrophin 3; D012333:RNA, Messenger; C073922:neurotrophin 4