Chemoenzymatic synthesis of iminocyclitol derivatives: a useful library strategy for the development of selective fucosyltransfer enzymes inhibitors.
A chemoenzymatic strategy has been developed for the synthesis of libraries of iminocyclitol derivatives for the discovery of new and selective fucosidase inhibitors.
Wischnat
R
R
Department of Chemistry, Scripps Research Institute, La Jolla, CA 92037, USA.
Martin
R
R
Takayama
S
S
Wong
C H
CH
D004791:Enzyme Inhibitors / Q000138:chemical synthesis*; D005644:alpha-L-Fucosidase / Q000037:antagonists & inhibitors*
D004791:Enzyme Inhibitors; D005644:alpha-L-Fucosidase