title: Synthesis of a series of sulfinic acid analogs of GABA and evaluation of their GABAB receptor affinities.
abstract: A series of gamma-aminobutyric acid (GABA) 1 analogs was prepared in which the carboxylic acid group of GABA was replaced with a sulfinic acid group and their affinity for the GABAB receptor investigated.
authors.affiliation: Department of Chemical Research, Schering-Plough Research Institute, Kenilworth, NJ 07033, USA.
authors.forename: N I
authors.initials: NI
authors.lastname: Carruthers
authors.forename: J M
authors.initials: JM
authors.lastname: Spitler
authors.forename: S C
authors.initials: SC
authors.lastname: Wong
authors.forename: D J
authors.initials: DJ
authors.lastname: Blythin
authors.forename: X
authors.initials: X
authors.lastname: Chen
authors.forename: H J
authors.initials: HJ
authors.lastname: Shue
authors.forename: H S
authors.initials: HS
authors.lastname: She
authors.forename: J F
authors.initials: JF
authors.lastname: Lee
authors.forename: C
authors.initials: C
authors.lastname: Rizzo
authors.forename: P C
authors.initials: PC
authors.lastname: Ting
authors.forename: R E
authors.initials: RE
authors.lastname: West
mesh_terms: D018080:Receptors, GABA-B / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013441:Sulfinic Acids / Q000138:chemical synthesis* / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000138:chemical synthesis* / Q000378:metabolism
chemical_list: D018080:Receptors, GABA-B; D013441:Sulfinic Acids; D005680:gamma-Aminobutyric Acid