Synthesis of praziquantel derivatives and their in vitro activity against adult Clonorchis sinensis.
Several praziquantel derivatives have been prepared by the acylation of compound 5, and examined on their biological activity in vitro a against adult Clonorchis sinensis collected from rabbits infected with metacercariae which was isolated from Pseudorasbora parva, a second intermediate host, captured in Nakdong river in Korea.
Kim
C S
CS
Division of Applied Science, Korea Institute of Science & Technology, Seoul, Korea.
Min
D Y
DY
D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis / Q000494:pharmacology*; D003004:Clonorchis sinensis / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D011223:Praziquantel / Q000031:analogs & derivatives* / Q000494:pharmacology*; D011817:Rabbits / Q000469:parasitology
D000871:Anthelmintics; D011223:Praziquantel