title: Maternal and perinatal factors related to maternal-infant transmission of HIV-1 in the P2C2 HIV study: the role of EBV shedding. Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV-1 Infection (P2C2 HIV) Study Group.
abstract: The association of maternal and perinatal factors with mother-infant transmission of HIV-1 was examined in a prospective multicenter cohort of singleton live births to 508 HIV-1-infected women with children of known HIV-1 infection status (91 [18%] HIV-1-infected, 417 [82%] uninfected). From multivariate logistic regression, independent predictors of HIV-1 transmission included maternal CD4 percentage (CD4%) (odds ratio [OR] per 10% increase in CD4% = 0.70; p = .003), ruptured membranes <24 hours (OR = 3.15; p = .02), and maternal bleeding (OR = 2.90; p = .03), whereas maternal zidovudine (ZDV) use was marginally associated (OR = 0.60; p = .08). The associations of maternal urinary cytomegalovirus (CMV) shedding, oropharyngeal Epstein-Barr virus (EBV) shedding, and serology profiles during pregnancy with HIV-1 transmission were examined in the subset of mothers in whom the CMV and EBV measurements were available. Maternal EBV seropositivity, CMV shedding, and CMV seropositivity were 100% (279 of 279), 7% (16 of 229), and 92% (270 of 274), respectively. These rates did not differ between transmitting and nontransmitting mothers. In univariate analyses, maternal EBV shedding was higher among transmitting than nontransmitting mothers (40 of 49 [82%] compared with 154 of 226 [68%]; p = .06) and was independently associated with transmission in multivariate logistic analyses adjusting for CD4%, ruptured membranes, and ZDV use, with an OR of 2.45 (95% confidence interval (CI), 1.03-5.84; p = .04). This permits the conclusion that EBV shedding is associated with maternal-infant HIV-1 transmission, independent of CD4%.
authors.affiliation: Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.
authors.forename: J
authors.initials: J
authors.lastname: Pitt
authors.forename: M
authors.initials: M
authors.lastname: Schluchter
authors.forename: H
authors.initials: H
authors.lastname: Jenson
authors.forename: A
authors.initials: A
authors.lastname: Kovacs
authors.forename: P
authors.initials: P
authors.lastname: LaRussa
authors.forename: K
authors.initials: K
authors.lastname: McIntosh
authors.forename: P
authors.initials: P
authors.lastname: Boyer
authors.forename: E
authors.initials: E
authors.lastname: Cooper
authors.forename: J
authors.initials: J
authors.lastname: Goldfarb
authors.forename: H
authors.initials: H
authors.lastname: Hammill
authors.forename: D
authors.initials: D
authors.lastname: Hodes
authors.forename: H
authors.initials: H
authors.lastname: Peavy
authors.forename: R
authors.initials: R
authors.lastname: Sperling
authors.forename: R
authors.initials: R
authors.lastname: Tuomala
authors.forename: W
authors.initials: W
authors.lastname: Shearer
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D016516:CD4-CD8 Ratio; D015331:Cohort Studies; D003587:Cytomegalovirus / Q000302:isolation & purification / Q000502:physiology; D005260:Female; D005865:Gestational Age; D015658:HIV Infections / Q000150:complications / Q000635:transmission* / Q000821:virology; D015497:HIV-1; D006566:Herpesviridae Infections / Q000150:complications / Q000821:virology; D004854:Herpesvirus 4, Human / Q000302:isolation & purification / Q000502:physiology*; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D009960:Oropharynx / Q000821:virology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology; D011446:Prospective Studies; D012307:Risk Factors; D014556:Urine / Q000821:virology; D014592:Uterine Hemorrhage / Q000150:complications; D017201:Virus Shedding; D015215:Zidovudine / Q000627:therapeutic use
chemical_list: D019380:Anti-HIV Agents; D015215:Zidovudine