title: Actinomycin D, C2 and VII, inhibitors of Grb2-SHC interaction produced by Streptomyces.
abstract: Actinomycin D, C2 and VII, cyclic peptides, inhibited Grb2 SH2 domain association (IC50 5-7 microM) with a phosphotyrosine containing peptide derived from the Shc protein (pTyr317). Actinomycins are the first examples of nonphosphorylated natural ligands of SH2 domain.
authors.affiliation: Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea.
authors.forename: J Y
authors.initials: JY
authors.lastname: Nam
authors.forename: H K
authors.initials: HK
authors.lastname: Kim
authors.forename: K H
authors.initials: KH
authors.lastname: Son
authors.forename: S U
authors.initials: SU
authors.lastname: Kim
authors.forename: B M
authors.initials: BM
authors.lastname: Kwon
authors.forename: M Y
authors.initials: MY
authors.lastname: Han
authors.forename: Y J
authors.initials: YJ
authors.lastname: Chung
authors.forename: S H
authors.initials: SH
authors.lastname: Bok
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D003609:Dactinomycin / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology*; D051380:GRB2 Adaptor Protein; D015394:Molecular Structure; D011506:Proteins / Q000037:antagonists & inhibitors*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D051380:GRB2 Adaptor Protein; D011506:Proteins; C116800:actinomycin VII; D003609:Dactinomycin; C116801:actinomycin C2