title: Synthesis and in vitro cancer cell growth inhibitory activity of monocyclic model compounds containing spongistatin triene side-chains.
abstract: Two monosaccharides embodying triene side-chains of the spongistatins display significant in vitro activity against human cancer cell lines.
authors.affiliation: Department of Chemistry, University of Pennsylvania, Philadelphia 19104, USA.
authors.forename: A B
authors.initials: AB
authors.lastname: Smith
authors.forename: Q
authors.initials: Q
authors.lastname: Lin
authors.forename: G R
authors.initials: GR
authors.lastname: Pettit
authors.forename: J C
authors.initials: JC
authors.lastname: Chapuis
authors.forename: J M
authors.initials: JM
authors.lastname: Schmidt
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002240:Carbohydrate Sequence; D002455:Cell Division / Q000187:drug effects; D004988:Ethers, Cyclic / Q000737:chemistry; D006801:Humans; D007783:Lactones / Q000737:chemistry; D018942:Macrolides; D008956:Models, Chemical; D008969:Molecular Sequence Data; D014407:Tumor Cells, Cultured / Q000187:drug effects; D000095702:Polyether Toxins
chemical_list: D000970:Antineoplastic Agents; D004988:Ethers, Cyclic; D007783:Lactones; D018942:Macrolides; C083856:spongistatin 1; D000095702:Polyether Toxins