title: Synthesis of bisindolylmaleimides using a palladium catalyzed cross-coupling reaction.
abstract: Bisindolylmaleimides are known to be potent and selective PKC inhibitors. A new synthesis of this class of compound is reported. The key step is a Suzuki cross-coupling reaction using a readily available indolylmaleimide triflate intermediate.
authors.affiliation: Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Neel
authors.forename: M R
authors.initials: MR
authors.lastname: Jirousek
authors.forename: J H
authors.initials: JH
authors.lastname: McDonald
mesh_terms: D002384:Catalysis; D003432:Cross-Linking Reagents / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D008301:Maleimides / Q000138:chemical synthesis* / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D011493:Protein Kinase C / Q000037:antagonists & inhibitors
chemical_list: D003432:Cross-Linking Reagents; D004791:Enzyme Inhibitors; D007211:Indoles; D008301:Maleimides; D010165:Palladium; D011493:Protein Kinase C; C088060:bisindolylmaleimide