Isolation and mapping of a novel human kidney- and liver-specific gene homologous to the bacterial acetyltransferases.
Using the differential display method to detect tissue-specific genes, we isolated a novel human gene, designated TSC501, that is expressed in kidney and liver. The cDNA contained an open reading frame of 681 nucleotides encoding 227 amino acids. The predicted product showed homologies in amino acid sequence to three different bacterial acetyltransferases, enzymes that are involved in drug resistance. Radiation hybrid mapping localized this gene to human chromosome bands 2p12-p13.1.
Ozaki
K
K
Otsuka GEN Research Institute Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan. ozakik@otsuka.genome.ad.jp
Fujiwara
T
T
Nakamura
Y
Y
Takahashi
E
E
D000123:Acetyltransferases / Q000737:chemistry / Q000235:genetics* / Q000302:isolation & purification*; D000595:Amino Acid Sequence; D000818:Animals; D001419:Bacteria / Q000201:enzymology*; D015152:Blotting, Northern; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D003001:Cloning, Molecular; D006801:Humans; D007668:Kidney / Q000201:enzymology*; D008099:Liver / Q000201:enzymology*; D051379:Mice; D018345:Mice, Knockout; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D016133:Polymerase Chain Reaction; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
D000123:Acetyltransferases; C116373:NAT8 protein, human