title: Characteristics of infantile cases of congenital dilatation of the bile duct.
abstract: OBJECTIVE
  This study was performed to clarify whether infants with congenital dilatation of the bile duct (CDBD) have any specific characteristics in comparison with older children.
  
  
  METHODS
  Of 153 cases with CDBD treated at our institution between 1959 and 1997, 34 (22.2%) were infants less than 1 year of age. The control group consisted of 46 children between 1 and 4 years of age. Symptoms, laboratory data, and histological findings were compared between these two groups.
  
  
  RESULTS
  As the initial symptoms, abdominal pain was not present in infantile cases, with a significant difference from the older children, and a significantly higher incidence of abdominal mass and acholic stools was noted in infantile cases. Laboratory data of serum aspartate transaminase and amylase level and amylase concentration in the bile of the common bile duct were significantly lower in the infant group than in the older children. The ratio of morphological type of cystic to cylindrical dilatation was 33 to 1 in infants with a significant difference from the control group.
  
  
  CONCLUSIONS
  Infantile cases of CDBD, which mostly have cystic type dilatation, in contrast to older children, are likely to present with abdominal mass. Pancreatitis with abdominal pain related to reflux of pancreatic juice into the biliary duct appears to be uncommon in infantile cases.
authors.affiliation: Department of Pediatric Surgery, Osaka University Medical School, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Shukri
authors.forename: T
authors.initials: T
authors.lastname: Hasegawa
authors.forename: M
authors.initials: M
authors.lastname: Wasa
authors.forename: J
authors.initials: J
authors.lastname: Higaki
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: A
authors.initials: A
authors.lastname: Okada
mesh_terms: D000681:Amylases / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001652:Bile Ducts / Q000473:pathology*; D001663:Bilirubin / Q000097:blood; D004108:Dilatation, Pathologic / Q000151:congenital; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male
chemical_list: D001219:Aspartate Aminotransferases; D000681:Amylases; D001663:Bilirubin