title: DNA gyrase inhibitory activity of ellagic acid derivatives.
abstract: Ellagic acid was found to inhibit E. coli DNA gyrase supercoiling with approximately the same potency as nalidixic acid. Tricyclic analogs of ellagic acid, which vary in the number and position of the hydroxy groups as well as their replacement with halogens, have been synthesized. The biological activity of these analogs is discussed.
authors.affiliation: R.W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Weinder-Wells
authors.forename: J
authors.initials: J
authors.lastname: Altom
authors.forename: J
authors.initials: J
authors.lastname: Fernandez
authors.forename: S A
authors.initials: SA
authors.lastname: Fraga-Spano
authors.forename: J
authors.initials: J
authors.lastname: Hilliard
authors.forename: K
authors.initials: K
authors.lastname: Ohemeng
authors.forename: J F
authors.initials: JF
authors.lastname: Barrett
mesh_terms: D004610:Ellagic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000201:enzymology; D013329:Structure-Activity Relationship; D059005:Topoisomerase II Inhibitors
chemical_list: D004791:Enzyme Inhibitors; D059005:Topoisomerase II Inhibitors; D004610:Ellagic Acid