title: 1-Methoxy-agroclavine from Penicillium sp. WC75209, a novel inhibitor of the Lck tyrosine kinase.
abstract: A high-throughput screen was developed and implemented to identify inhibitors of the Lck tyrosine kinase. This report describes the identification of a specific inhibitor of this enzyme from the solid fermentation culture of the Penicillium sp., WC75209. The active compound was isolated and structurally characterized as 1-methoxy-5R, 10S-agroclavine, a new member of the ergot alkaloid family.
authors.affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT, USA.
authors.forename: R
authors.initials: R
authors.lastname: Padmanabha
authors.forename: Y Z
authors.initials: YZ
authors.lastname: Shu
authors.forename: L S
authors.initials: LS
authors.lastname: Cook
authors.forename: J A
authors.initials: JA
authors.lastname: Veitch
authors.forename: M
authors.initials: M
authors.lastname: Donovan
authors.forename: S
authors.initials: S
authors.lastname: Lowe
authors.forename: S
authors.initials: S
authors.lastname: Huang
authors.forename: D
authors.initials: D
authors.lastname: Pirnik
authors.forename: S P
authors.initials: SP
authors.lastname: Manly
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004873:Ergolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / Q000037:antagonists & inhibitors*; D008956:Models, Chemical; D010407:Penicillium / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: C116603:1-methoxyagroclavine; D004791:Enzyme Inhibitors; D004873:Ergolines; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck)