title: Synthesis and binding studies of a 1-alkyl-3,6-diamino-4-quinolone based receptor for N-acylated dipeptides.
abstract: The synthesis and binding properties of a semirigid host for N-acyldipeptide carboxylic acids is presented. The design is based on the rigidification of a peptide strand, coupled to the use of a substituted quinoline as a hydrogen bond acceptor for the proton of a carboxylic acid.
authors.affiliation: Department of Chemistry, University of Pittsburgh, PA 15260, USA.
authors.forename: W S
authors.initials: WS
authors.lastname: Weiner
authors.forename: A D
authors.initials: AD
authors.lastname: Hamilton
mesh_terms: D000215:Acylation; D004151:Dipeptides / Q000378:metabolism*; D015195:Drug Design; D006860:Hydrogen Bonding; D008958:Models, Molecular; D018716:Molecular Mimicry; D011485:Protein Binding; D017433:Protein Structure, Secondary; D015363:Quinolones / Q000138:chemical synthesis* / Q000378:metabolism*
chemical_list: D004151:Dipeptides; D015363:Quinolones