title: Fissure penetration and antibacterial effect in vitro of a glass ionomer cement containing chlorhexidine gluconate.
abstract: Chlorhexidine has been incorporated in different varnishes to provide a slow release system on the tooth surface in order to reduce mutans streptococci. To provide an alternative vehicle for chlorhexidine with better adhesion properties compared to resin-based varnishes, glass ionomer cement (GI) has been suggested. However, one disadvantage for glass ionomers is a longer setting time compared to the resin-based varnishes. The aim with this study was to compare the fissure penetration and antibacterial characteristics of a glass-ionomer cement (GI) with a GI containing chlorhexidine gluconate (GI-CHX), and GI-CHX with added tataric acid (GI-CHX-TA) to reduce its setting time. Antibacterial properties against mutans streptococci were assessed by agar diffusion. GI, GI-CHX and GI-CHX-TA were applied with a microbrush on the occlusal surfaces of 4, 4 and 6 extracted molars respectively. After setting of cements, sections were ground with 1 mm intervals and photographed. The fissure penetration and adaptation of the cements were scored excellent, acceptable or unacceptable under blind conditions according to a standard. Seventy percent scored excellent with GI-CHX-TA (n = 54) compared with 40% with GI-CHX (n = 48) and 38% with GI (n = 40), (p < 0.05). GI-CHX and GI-CHX-TA had significant better antibacterial properties compared to GI or GI with added tataric acid only.
authors.affiliation: Department of Cariology, Faculty of Odontology, University of Lund, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Hoszek
authors.forename: F
authors.initials: F
authors.lastname: Pierreville
authors.forename: M
authors.initials: M
authors.lastname: Schittek
authors.forename: D
authors.initials: D
authors.lastname: Ericson
mesh_terms: D000704:Analysis of Variance; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000494:pharmacology*; D002710:Chlorhexidine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D003745:Dental Enamel Permeability; D003750:Dental Fissures / Q000517:prevention & control*; D005899:Glass Ionomer Cements / Q000737:chemistry*; D006801:Humans; D005779:Immunodiffusion; D011897:Random Allocation; D018709:Statistics, Nonparametric; D013295:Streptococcus mutans / Q000187:drug effects; D013644:Tartrates / Q000737:chemistry
chemical_list: D000891:Anti-Infective Agents, Local; D005899:Glass Ionomer Cements; D013644:Tartrates; C010882:chlorhexidine gluconate; D002710:Chlorhexidine; C029768:tartaric acid