title: P2-proline-derived inhibitors of calpain I.
abstract: The syntheses and biological activities of a series of calpain I inhibitors, derived from D- and L-Pro, are described.
authors.affiliation: Department of Chemistry, Cephalon, Inc., West Chester, PA 19380-4245, USA.
authors.forename: R
authors.initials: R
authors.lastname: Tripathy
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Gu
authors.forename: D
authors.initials: D
authors.lastname: Dunn
authors.forename: S E
authors.initials: SE
authors.lastname: Senadhi
authors.forename: M A
authors.initials: MA
authors.lastname: Ator
authors.forename: S
authors.initials: S
authors.lastname: Chatterjee
mesh_terms: D002154:Calpain / Q000037:antagonists & inhibitors*; D015853:Cysteine Proteinase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D011392:Proline / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D015853:Cysteine Proteinase Inhibitors; D011392:Proline; D002154:Calpain