title: Altered radiopharmaceutical distribution in myeloma: bone tracer in the heart and heart tracer in the bone.
abstract: Tissue deposits of amyloid may lead to various clinical symptoms and signs, depending on the site of deposition. In addition, a specific subtype of amyloidosis, AL protein type, is associated with multiple myeloma. Two cases representing contrasting examples of altered radiopharmaceutical biodistribution in myeloma and amyloidosis are presented and discussed, with a bone tracer depicting the heart and a heart tracer depicting the bones.
authors.affiliation: Department of Radiology, University of Michigan Medical Center, Ann Arbor, USA.
authors.forename: A K
authors.initials: AK
authors.lastname: Gupta
authors.forename: P
authors.initials: P
authors.lastname: Meyer
authors.forename: M D
authors.initials: MD
authors.lastname: Gross
authors.forename: L M
authors.initials: LM
authors.lastname: Fig
authors.forename: B
authors.initials: B
authors.lastname: Shapiro
mesh_terms: D000368:Aged; D000686:Amyloidosis / Q000000981:diagnostic imaging*; D001859:Bone Neoplasms / Q000000981:diagnostic imaging*; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D009202:Cardiomyopathies / Q000000981:diagnostic imaging*; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D009101:Multiple Myeloma / Q000000981:diagnostic imaging*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D013669:Technetium Tc 99m Medronate / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D013794:Thallium Radioisotopes / Q000493:pharmacokinetics; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019275:Radiopharmaceuticals; D013794:Thallium Radioisotopes; C024226:technetium Tc 99m hydroxymethylene diphosphonate; D013669:Technetium Tc 99m Medronate