title: Recent improvements of the ProDom database of protein domain families.
abstract: The ProDom database contains protein domain families generated from the SWISS-PROT database by automated sequence comparisons. The current version was built with a new improved procedure based on recursive PSI-BLAST homology searches. ProDom can be searched on the World Wide Web to study domain arrangements within either known families or new proteins, with the help of a user-friendly graphical interface (http://www.toulouse.inra.fr/prodom.html). Recent improvements to the ProDom server include: ProDom queries under the SRS Sequence Retrieval System; links to the PredictProtein server; phylogenetic trees and condensed multiple alignments for a better representation of large domain families, with zooming in and out capabilities. In addition, a similar server was set up to display the outcome of whole genome domain analysis as applied to 17 completed microbial genomes (http://www.toulouse.inra.fr/prodomCG.html ).
authors.affiliation: Laboratoire de Génétique Cellulaire, INRA, BP27, F-31326 Castanet-Tolosan cedex, France. fcorpet@toulouse.inra.fr
authors.forename: F
authors.initials: F
authors.lastname: Corpet
authors.forename: J
authors.initials: J
authors.lastname: Gouzy
authors.forename: D
authors.initials: D
authors.lastname: Kahn
mesh_terms: D000595:Amino Acid Sequence; D016208:Databases, Factual; D016247:Information Storage and Retrieval; D020407:Internet; D010802:Phylogeny; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000145:classification*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D014584:User-Computer Interface
chemical_list: D011506:Proteins