title: [Dosage of anesthetics--a tricky question].
abstract: The optimal dosage of anaesthetic agents may be difficult. Not only does the intensity of surgical stimuli vary during a surgical procedure, but drug sensitivity varies between subjects exposed to comparable stimuli. Moreover, clinically monitored body reactions do not always reflect the balance between central nervous system effects of the surgical stimuli and of the anaesthetic agent. Therefore, the specialist in anaesthesiology requires access to additional methods of monitoring to enable dosage to be optimised for each patient, minute by minute, thus improving the chances of maintaining an appropriate depth of anaesthesia. Two electro-encephalographic techniques are presented in the article, and aspects of under- and over-dosage of anaesthetic agents are discussed.
authors.affiliation: Institutionen för anestesiologi och intensivvård, Uppsala universitet, Samariterhemmets sjukhus.
authors.forename: M
authors.initials: M
authors.lastname: Enlund
authors.forename: R
authors.initials: R
authors.lastname: Sandin
authors.forename: P
authors.initials: P
authors.lastname: Samuelsson
authors.forename: P
authors.initials: P
authors.lastname: Reinstrup
authors.forename: J
authors.initials: J
authors.lastname: Hidestål
authors.forename: J
authors.initials: J
authors.lastname: Jakobsson
mesh_terms: D018681:Anesthetics, General / Q000008:administration & dosage* / Q000009:adverse effects / Q000506:poisoning; D001364:Awareness; D062787:Drug Overdose; D004569:Electroencephalography / Q000379:methods*; D006801:Humans; D016343:Monitoring, Intraoperative / Q000379:methods*; D009474:Neurons / Q000187:drug effects
chemical_list: D018681:Anesthetics, General
vernacular_title: Narkosdosering--en svår balansgång.