[Is there still a role for radical cystectomy in localized, infiltrating bladder cancers in 1998?].
The role of radical cystectomy as the standard treatment of localised infiltrating bladder malignancy is challenged by the development radiotherapy and chemotherapy combinations. The published studies are difficult to compare because of large differences in the patients selection criteria and in the assessment of local involvement (only clinical in combined treatment, based on pathology and therefore unquestionable in surgical series). The advantages of radical surgery are its precedence and a well-established technique, simplified follow-up procedures and seemingly higher survival rates acquired after 3 years. Conversely, the combination of radiotherapy and chemotherapy allows bladder preservation in about 40% of the patients (at 5 years), but only in 23% without bladder relapses. A complete initial endoscopic resection is the best and only prognostic factor of these results which nevertheless needs a very carefully and endless follows. The comparison of the quality of life achieved by both treatment modalities remains insufficiently documented.
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Service d'urologie, Hôpital Foch, Suresnes, France.
D002295:Carcinoma, Transitional Cell / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D003131:Combined Modality Therapy; D015653:Cystectomy / Q000009:adverse effects / Q000379:methods* / Q000639:trends; D003558:Cystoscopy; D004724:Endoscopy; D005500:Follow-Up Studies; D006801:Humans; D011379:Prognosis; D012107:Research Design / Q000592:standards; D016019:Survival Analysis; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*
Y a-t-il encore de la place pour la cystectomie radicale dans les cancers de vessie infiltrants localisés en 1998?