title: Biological properties of synthetic glycoconjugate mimics of heparin comprising different molecular spacers.
abstract: The in vitro antithrombotic activity of synthetic glycoconjugates I and II, comprising a flexible polyethylene glycol type and a rigid polyglucose type spacer, respectively, are compared to heparin.
authors.affiliation: N.V. Organon Scientific Development Group, Oss, The Netherlands.
authors.forename: C M
authors.initials: CM
authors.lastname: Dreef-Tromp
authors.forename: J E
authors.initials: JE
authors.lastname: Basten
authors.forename: M A
authors.initials: MA
authors.lastname: Broekhoven
authors.forename: T G
authors.initials: TG
authors.lastname: van Dinther
authors.forename: M
authors.initials: M
authors.lastname: Petitou
authors.forename: C A
authors.initials: CA
authors.lastname: van Boeckel
mesh_terms: D000925:Anticoagulants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D065427:Factor Xa Inhibitors; D006001:Glycoconjugates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006493:Heparin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008969:Molecular Sequence Data; D010978:Platelet Factor 4 / Q000037:antagonists & inhibitors; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013917:Thrombin / Q000037:antagonists & inhibitors*
chemical_list: D000925:Anticoagulants; D065427:Factor Xa Inhibitors; D006001:Glycoconjugates; D010978:Platelet Factor 4; D011092:Polyethylene Glycols; D006493:Heparin; D013917:Thrombin