The synthesis of symmetrical spermine conjugates using solid-phase chemistry.
The utility of spermine, selectively functionalised and immobilised on a solid support by means of the Wang "oxycarbonyl" linker is demonstrated by the solid-phase synthesis of a number of spermine conjugates including the natural product and potent antihypertensive agent kukoamine. The synthesis opens up the area of solid-phase spermine chemistry and library generation based on the symmetrical spermine scaffold.
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Department of Chemistry, University of Southampton, UK.
Burrage
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Baldock
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Bradley
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D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013096:Spermine / Q000737:chemistry*
D013096:Spermine