The use of antibiotic-impregnated cement in infected reconstructions after resection for bone tumours.
We have studied 35 patients with infected reconstructions after segmental resection for bone tumours. Two different regimes of treatment were employed both of which entailed debridement and the use of cement impregnated with antibiotic. In 25 patients gentamicin-PMMA beads were used and in ten an antibiotic-impregnated cement spacer. Better results were achieved with the second procedure in terms of cases healed, the number of operations, time of healing, time of recovery and the functional score. The use of vancomycin in the cement spacer gave better local control.
Donati
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1st Orthopaedic Clinic, University of Bologna, Rizzoli Orthopaedic Institute, Italy.
Biscaglia
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R
D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001843:Bone Cements; D001859:Bone Neoplasms / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D003646:Debridement; D005839:Gentamicins / Q000008:administration & dosage; D006801:Humans; D008768:Methylmethacrylates; D008875:Middle Aged; D019919:Prosthesis Implantation / Q000379:methods; D019651:Plastic Surgery Procedures / Q000379:methods*; D013530:Surgical Wound Infection / Q000188:drug therapy*; D014640:Vancomycin / Q000008:administration & dosage; D014945:Wound Healing / Q000187:drug effects
D000900:Anti-Bacterial Agents; D001843:Bone Cements; D005839:Gentamicins; D008768:Methylmethacrylates; D014640:Vancomycin