title: Non-traumatic rhabdomyolysis with gluteal ulcer.
abstract: The case is presented of a 34-year-old woman with rhabdomyolysis due to massive intake of nimetazepam, a benzodiazepine hypnotic. On admission, the patient had numerous blisters all over the body. One of the blisters in the gluteal region developed into a deep ulcer accompanied by muscle necrosis although it was not at a pressure point. The ulcer needed surgical intervention. Rhabdomyolysis is caused by the lysis and necrosis of muscle due to direct or indirect injury, high fever, ischaemia, hypoxia or enzyme defects. Release of myocyte components into the circulation then may induce major problems, especially acute renal failure associated with hypermyoglobinaemia. However, there have been few reports of cutaneous ulcer formation in non-traumatic rhabdomyolysis.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Hirosaki University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yotsuyanagi
authors.forename: Y
authors.initials: Y
authors.lastname: Nihei
authors.forename: Y
authors.initials: Y
authors.lastname: Sawada
mesh_terms: D000328:Adult; D002081:Buttocks; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects*; D009567:Nitrazepam / Q000009:adverse effects / Q000031:analogs & derivatives*; D012206:Rhabdomyolysis / Q000139:chemically induced*; D012883:Skin Ulcer / Q000139:chemically induced* / Q000473:pathology
chemical_list: D006993:Hypnotics and Sedatives; C002714:nimetazepam; D009567:Nitrazepam