Evidence for a chromosome 2p13-14 schizophrenia susceptibility locus in families from Palau, Micronesia.
A large multiplex schizophrenia pedigree ascertained from the Micronesian nation of Palau was genotyped with 406 microsatellite DNA markers evenly distributed throughout the genome. Assuming autosomal dominant inheritance, the highest genome-wide lod scores were found for DNA loci mapping to 2p13-14; the maximum lod score was 2.17 (theta = 0.05) at D2S441. A nonparametric APM analysis was also suggestive at D2S441 (APM score = 2.96, P = 0.011). Of the 14 affected cases in this extended family, eight share a large haplotype in this region spanning approximately 11 cM. When 16 other families containing 65 schizophrenic cases were typed in a follow-up study of this region, the maximum lod score remained positive (maximum at D2S441 1.69, theta = 0.20). APM results also remained positive at D2S441 for all 17 families (APM score = 4.87, P = 0.0006). The linkage and haplotype sharing results provide suggestive evidence for a 2p locus predisposing to schizophrenia in a subset of families in the Palauan population.
Coon
H
H
Department of Psychiatry, University of Utah School of Medicine, Salt Lake City 84132, USA.
Myles-Worsley
M
M
Tiobech
J
J
Hoff
M
M
Rosenthal
J
J
Bennett
P
P
Reimherr
F
F
Wender
P
P
Dale
P
P
Polloi
A
A
Byerley
W
W
D000328:Adult; D017668:Age of Onset; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D005260:Female; D005500:Follow-Up Studies; D005799:Genes, Dominant; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D008126:Lod Score; D008297:Male; D008849:Micronesia; D010375:Pedigree; D012559:Schizophrenia / Q000235:genetics*; D018709:Statistics, Nonparametric
D005819:Genetic Markers