title: Leishmaniasis recidiva cutis in New World cutaneous leishmaniasis.
abstract: BACKGROUND
  Leishmaniasis recidiva cutis (LRC) is rare in New World leishmaniasis. Only seven cases have been reported so far.
  
  
  METHODS
  Four cases are reported here. Parasite diagnosis was performed by classical methods of touch preparations, histopathologic sections, and cultures. In addition, the detection of parasite DNA by the polymerase chain reaction (PCR) was performed in all cases.
  
  
  RESULTS
  Parasites were detected by at least one of the classical methods in all primary lesions; however, only the PCR was positive in the recidivant lesions.
  
  
  CONCLUSIONS
  LRC cases most likely represent a reactivation of an initial infection, probably due to the persistence of parasites in scarred tissue. Although lupoid leishmaniasis (LL) has been used as a synonym of LRC, a clear difference between LRC and LL can be defined as LL is the initial clinical presentation while LRC is a recurrent lesion.
  
  
  CONCLUSIONS
  The results indicate that it is not appropriate to use these two denominations as synonyms. The designation of LRC should be maintained in order to define recidives occurring at the border of an old scar of cutaneous leishmaniasis, avoiding the confusion with the lupoid form of the disease.
authors.affiliation: Hospital Evandro Chagas, Departamento de Protozoologia, Instituto Oswaldo Cruz (IOC), and FIOCruz, Rio de Janeiro, Brazil.
authors.forename: M P
authors.initials: MP
authors.lastname: Oliveira-Neto
authors.forename: M
authors.initials: M
authors.lastname: Mattos
authors.forename: C S
authors.initials: CS
authors.lastname: Souza
authors.forename: O
authors.initials: O
authors.lastname: Fernandes
authors.forename: C
authors.initials: C
authors.lastname: Pirmez
mesh_terms: D000328:Adult; D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D001706:Biopsy; D016054:DNA, Protozoan / Q000032:analysis / Q000235:genetics; D005260:Female; D006801:Humans; D007891:Leishmania / Q000235:genetics / Q000302:isolation & purification; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D008297:Male; D008536:Meglumine / Q000627:therapeutic use; D000077485:Meglumine Antimoniate; D009942:Organometallic Compounds / Q000627:therapeutic use; D016133:Polymerase Chain Reaction; D012867:Skin / Q000187:drug effects / Q000469:parasitology / Q000473:pathology*
chemical_list: D000981:Antiprotozoal Agents; D016054:DNA, Protozoan; D009942:Organometallic Compounds; D008536:Meglumine; D000077485:Meglumine Antimoniate