title: Effect of lutein on beta-carotene absorption and cleavage.
abstract: Carotenoid interactions during absorption and in postabsorptive metabolism have been observed in both human and animal studies. We reviewed the mutual interactions reported between lutein and beta-carotene and report new data on the postprandial beta-carotene and retinyl ester response in the triglyceride-rich plasma lipoprotein (TRL) fraction in volunteers after a single test meal with beta-carotene alone, or beta-carotene combined with lutein or lycopene. Results indicate an inhibitory effect of lutein on beta-carotene absorption, but apparently not on beta-carotene cleavage. In a comparative study with two beta-carotene/lutein ratios (2:1 and 1:2, respectively), this inhibitory effect of lutein was found to be most marked when lutein was the predominant carotenoid. In studies on plasma (serum) response also an inhibitory effect of beta-carotene on lutein response was observed.
authors.affiliation: TNO Nutrition and Food Research Institute, Zeist, Netherlands.
authors.forename: H
authors.initials: H
authors.lastname: van den Berg
mesh_terms: D000042:Absorption; D000818:Animals; D002914:Chylomicrons / Q000378:metabolism; D004032:Diet; D004224:Diterpenes; D004347:Drug Interactions; D006801:Humans; D008074:Lipoproteins / Q000097:blood; D014975:Lutein / Q000008:administration & dosage / Q000494:pharmacology*; D000084562:Retinyl Esters; D014801:Vitamin A / Q000031:analogs & derivatives / Q000097:blood; D019207:beta Carotene / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*
chemical_list: D002914:Chylomicrons; D004224:Diterpenes; D008074:Lipoproteins; D000084562:Retinyl Esters; D019207:beta Carotene; D014801:Vitamin A; C014794:retinol palmitate; D014975:Lutein