title: Reversal of multidrug resistance (MDR) by aspidofractinine-type indole alkaloids.
abstract: A series of indole alkaloids of the aspidofractinine-type was assessed for their potential in reversing MDR in vincristine-resistant KB cells. Of the compounds tested, kopsiflorine, kopsamine, pleiocarpine, 11-methoxykopsilongine, lahadinine A and N-methoxycarbonyl-11,12-methylenedioxy-delta 16,17-kopsinine were found to show appreciable activity.
authors.affiliation: Department of Chemistry, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: T S
authors.initials: TS
authors.lastname: Kam
authors.forename: G
authors.initials: G
authors.lastname: Subramaniam
authors.forename: K M
authors.initials: KM
authors.lastname: Sim
authors.forename: K
authors.initials: K
authors.lastname: Yoganathan
authors.forename: T
authors.initials: T
authors.lastname: Koyano
authors.forename: M
authors.initials: M
authors.lastname: Toyoshima
authors.forename: M C
authors.initials: MC
authors.lastname: Rho
authors.forename: M
authors.initials: M
authors.lastname: Hayashi
authors.forename: K
authors.initials: K
authors.lastname: Komiyama
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D014750:Vincristine / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D007211:Indoles; C061457:kopsinine F; D014750:Vincristine