title: Structure-function of cytochromes P450 and flavin-containing monooxygenases: implications for drug metabolism.
abstract: This article is a report on a symposium held at Experimental Biology '98 in San Francisco, California. Recent developments in site-directed mutagenesis, computer-modeling, and mechanistic analysis of cytochromes P450 and flavin-containing monooxygenases are described. A unifying theme is the elaboration of general approaches for understanding and predicting the function of individual forms of these enzymes. A related goal is the production of soluble forms of mammalian cytochromes P450 for X-ray crystallography.
authors.affiliation: Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, USA. jhalpert@utmb.edu
authors.forename: J R
authors.initials: JR
authors.lastname: Halpert
authors.forename: T L
authors.initials: TL
authors.lastname: Domanski
authors.forename: O
authors.initials: O
authors.lastname: Adali
authors.forename: C P
authors.initials: CP
authors.lastname: Biagini
authors.forename: J
authors.initials: J
authors.lastname: Cosme
authors.forename: E A
authors.initials: EA
authors.lastname: Dierks
authors.forename: E F
authors.initials: EF
authors.lastname: Johnson
authors.forename: J P
authors.initials: JP
authors.lastname: Jones
authors.forename: P
authors.initials: P
authors.lastname: Ortiz de Montellano
authors.forename: R M
authors.initials: RM
authors.lastname: Philpot
authors.forename: O
authors.initials: O
authors.lastname: Sibbesen
authors.forename: W K
authors.initials: WK
authors.lastname: Wyatt
authors.forename: Z
authors.initials: Z
authors.lastname: Zheng
mesh_terms: D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry / Q000378:metabolism*; D005415:Flavins / Q000378:metabolism*; D006801:Humans; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D005415:Flavins; D004364:Pharmaceutical Preparations; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases