High throughput purification of combinatorial libraries.
This article summarizes recent advances at MDS Panlabs which provide for the high-throughput preparative HPLC purification of our Optiverse screening library. Topics covered include unique methods for the preparation, purification, characterization, and plating of purified screening compounds. Also discussed are procedures for data tracking as samples proceed through the purification process.
Schultz
L
L
Department of Chemistry, MDS Panlabs, Bothell, WA 98011, USA.
Garr
C D
CD
Cameron
L M
LM
Bukowski
J
J
D002625:Chemistry, Organic / Q000379:methods*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D019992:Databases as Topic; D015195:Drug Design; D007202:Indicators and Reagents; D013329:Structure-Activity Relationship
D007202:Indicators and Reagents