Synthesis and acetylcholinesterase inhibitory activity of (+/-)-14-fluorohuperzine A.
The synthesis of (+/-)-14-Fluorohuperzine A has been accomplished and the ability of this agent to inhibit acetylcholinesterase has been measured. Taking into account its racemic form, this compound exhibits 62 times less potent activity than natural (-)-huperzine A.
Zeng
F
F
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Jiang
H
H
Tang
X
X
Chen
K
K
Ji
R
R
D000818:Animals; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects / Q000201:enzymology; D051381:Rats; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000494:pharmacology*
C116656:14-fluorohuperzine A; D002800:Cholinesterase Inhibitors; D012717:Sesquiterpenes