title: The first conversion of camptothecin to (S)-mappicine by an efficient chemoenzymatic method.
abstract: Camptothecin has been converted for the first time to (S)-mappicine via mappicine ketone, which is the sole product of the microwave irradiation of camptothecin. Baker's yeast reduction of mappicine ketone yielded (S)-mappicine in high optical purity.
authors.affiliation: Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad, India.
authors.forename: B
authors.initials: B
authors.lastname: Das
authors.forename: P
authors.initials: P
authors.lastname: Madhusudhan
authors.forename: A
authors.initials: A
authors.lastname: Kashinatham
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D002166:Camptothecin / Q000737:chemistry* / Q000528:radiation effects; D008872:Microwaves; D012441:Saccharomyces cerevisiae / Q000201:enzymology; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; C008325:mappicine; D002166:Camptothecin