Synthesis and evaluation of a novel series of phosphodiesterase IV inhibitors. A potential treatment for asthma.
The synthesis and pharmacological profile of a novel series of potent and selective phosphodiesterase type IV (PDE IV) inhibitors is described.
Beasley
S C
SC
Chiroscience Ltd, Cambridge.
Cooper
N
N
Gowers
L
L
Gregory
J P
JP
Haughan
A F
AF
Hellewell
P G
PG
Macari
D
D
Miotla
J
J
Montana
J G
JG
Morgan
T
T
Naylor
R
R
Runcie
K A
KA
Tuladhar
B
B
Warneck
J B
JB
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000577:Amides / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000494:pharmacology; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D004802:Eosinophilia / Q000188:drug therapy; D006168:Guinea Pigs; D010726:Phosphodiesterase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D015363:Quinolones / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000577:Amides; D018927:Anti-Asthmatic Agents; D002264:Carboxylic Acids; D010726:Phosphodiesterase Inhibitors; D015363:Quinolones; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4