title: [Acquired cytomegalovirus infections in immunocompetent adults: 116 cases].
abstract: OBJECTIVE
  To analyse retrospectively the clinical, biological and epidemiological features of cytomegalovirus (CMV) infection in the immunocompetent host.
  
  
  METHODS
  A retrospective study was conducted in 116 cases of CMV infection (74 inpatients, 42 out-patients) collected from 1981 to 1997 in a university hospital. Diagnostic was established on serological criteria in all cases.
  
  
  RESULTS
  Fever was observed in all cases but one (mean duration: 21 days). The most frequent symptoms were headache (51%) and myalgia (46%). Splenomegaly was the most frequent sign (36%). Pulmonary interstitial opacities on chest x-ray were found in 8.5% of patients. Pulmonary (1 case) and neurological (2 cases) complications occurred. Concomitant HIV primary infection was observed in 2 patients. Mononucleosis and ALAT and LDH elevations were observed in 95%, 85% and 95% of cases respectively. Viremia was positive in 79% (30/38). pp65 antigenemia was useful to establish the diagnosis in 9 patients. Antibiotics were prescribed in 46% before diagnosis was established.
  
  
  CONCLUSIONS
  CMV infection in the immunocompetent host is a frequent and rarely complicated disease. pp65 antigenemia should be evaluated more in this setting. Most hospitalizations due to this affection could be avoided.
authors.affiliation: Service des Maladies infectieuses et tropicales, Hôpital Gui de Chauliac, Montpellier.
authors.forename: J F
authors.initials: JF
authors.lastname: Faucher
authors.forename: B
authors.initials: B
authors.lastname: Abraham
authors.forename: M
authors.initials: M
authors.lastname: Segondy
authors.forename: O
authors.initials: O
authors.lastname: Jonquet
authors.forename: J
authors.initials: J
authors.lastname: Reynes
authors.forename: F
authors.initials: F
authors.lastname: Janbon
mesh_terms: D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000175:diagnosis / Q000821:virology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007297:Inpatients; D008297:Male; D008875:Middle Aged; D010045:Outpatients; D012189:Retrospective Studies; D012698:Serologic Tests
chemical_list: D000914:Antibodies, Viral; D007136:Immunoglobulins
vernacular_title: Cytomégalovirose acquise de l'adulte immunocompétent. 116 observations.