[Clinical study of integrated traditional and Western medicine therapy on hepatolenticular degeneration].
OBJECTIVE
To investigate the curative effect of integrated traditional and western medicine (TCM-WM) therapy on hepatolenticular degeneration (HLD).


METHODS
Eighty patients with HLD were divided randomly into two groups (TCM-WM group and WM group), TCM-WM group (40 cases) were given orally dimercaptosuccinic acid (DMSA) and Gandou ([symbol: see text]) decoction for 1 month. The efficacy was compared with that of 40 cases treated with DMSA as the control. The changes of urinary trace and macro-elements before and after treatment were observed.


RESULTS
The total effective rate of TCM-WM group was significantly higher than that of WM group (P < 0.05), especially more patients with hepatic type responded well to treatment with TCM-WM than with only chelating agent DMSA. Urinary trace and macro-elements were all obviously elevated in patients of two groups after treatment (P < 0.01).


CONCLUSIONS
TCM-WM therapy appears extremely promising as new cupruretic method for treatment of HLD. It is particularly suitable for treating the patient with hepatic type.
Ren
M S
MS
Institute of Neurology, Affiliated Hospital, Anhui College of TCM, Hefei.
Zhang
B
B
Yang
R M
RM
D000293:Adolescent; D000328:Adult; D002614:Chelating Agents / Q000627:therapeutic use; D002648:Child; D003300:Copper / Q000652:urine; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006527:Hepatolenticular Degeneration / Q000188:drug therapy* / Q000652:urine; D006801:Humans; D008297:Male; D004113:Succimer / Q000627:therapeutic use
D002614:Chelating Agents; D004365:Drugs, Chinese Herbal; D003300:Copper; D004113:Succimer