title: Perioperative outcomes of major hepatic resections under low central venous pressure anesthesia: blood loss, blood transfusion, and the risk of postoperative renal dysfunction.
abstract: BACKGROUND
  We have previously demonstrated that maintenance of a low central venous pressure (LCVP) combined with extrahepatic control of venous outflow reduced the overall blood loss during major hepatic resections. This study examined the overall outcomes and, in particular, renal morbidity associated with a large series of consecutive major liver resections performed with this approach. In addition, the rationale for the anesthetic management to maintain LCVP was carefully reviewed.
  
  
  METHODS
  All major hepatectomies performed between December 1991 and April 1997 were reviewed. The prospective Hepatobiliary Surgical Service database was merged with the Memorial Hospital Laboratory and Blood Bank databases to yield the nature of the operation, blood loss, blood product transfusions, outcomes, and levels of preoperative, postoperative, and discharge serum creatinine and blood urea nitrogen.
  
  
  RESULTS
  A total of 496 LCVP-assisted major liver resections were performed, with no intraoperative deaths and an in-hospital mortality rate of 3.8%. The median blood loss was 645 mL. Sixty-seven percent of the patients did not require perioperative blood transfusion during surgery and the immediate 12 hours after surgery. The median number of blood transfusions was 2. Only 3% of the patients experienced a persistent and clinically significant increase in serum creatinine possibly attributable to the anesthetic technique. Renal failure directly attributable to the anesthetic technique did not occur.
  
  
  CONCLUSIONS
  Major resection with LCVP allowed easy control of the hepatic veins before and during parenchymal transection. The anesthetic technique, designed to maintain LCVP during the critical stages of hepatic resection, not only helped to minimize blood loss and mortality but also preserved renal function.
authors.affiliation: Department of Anesthesiology, Memorial Sloan-Kettering Cancer Center, New York, NY 10024, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Melendez
authors.forename: V
authors.initials: V
authors.lastname: Arslan
authors.forename: M E
authors.initials: ME
authors.lastname: Fischer
authors.forename: D
authors.initials: D
authors.lastname: Wuest
authors.forename: W R
authors.initials: WR
authors.lastname: Jarnagin
authors.forename: Y
authors.initials: Y
authors.lastname: Fong
authors.forename: L H
authors.initials: LH
authors.lastname: Blumgart
mesh_terms: D016063:Blood Loss, Surgical / Q000503:physiopathology*; D001803:Blood Transfusion; D001806:Blood Urea Nitrogen; D002423:Cause of Death; D002496:Central Venous Pressure / Q000502:physiology*; D003404:Creatinine / Q000097:blood; D006498:Hepatectomy / Q000379:methods*; D017052:Hospital Mortality; D006801:Humans; D007023:Hypotension, Controlled / Q000379:methods*; D007511:Ischemia / Q000503:physiopathology; D007668:Kidney / Q000098:blood supply; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary / Q000601:surgery*; D011183:Postoperative Complications / Q000401:mortality / Q000503:physiopathology*; D011446:Prospective Studies; D051437:Renal Insufficiency / Q000401:mortality / Q000503:physiopathology*; D012307:Risk Factors
chemical_list: D003404:Creatinine