N'-methylniphimycin, a novel minor congener of niphimycin from Streptomyces spec. 57-13.
A novel natural niphimycin analog, N'-methylniphimycin was isolated from the culture broth of the Streptomyces spec. 57-13. The chemical constitution was elucidated from the physico-chemical properties, NMR techniques and mass spectrometry to be a 36-membered macrolide related to azalomycin F5a, shurimycin B and RS-22C. N'-methylniphimycin displayed moderate activity against some yeasts and filamentous fungi.
Ivanova
V
V
Institute of Microbiology, Bulgarian Academy of Sciences, Acad. G. Bonchev, Sofia, Bulgaria.
Schlegel
R
R
Dornberger
K
K
D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D005658:Fungi / Q000187:drug effects; D006146:Guanidines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013058:Mass Spectrometry; D013302:Streptomyces / Q000737:chemistry* / Q000254:growth & development; D015003:Yeasts / Q000187:drug effects
D000935:Antifungal Agents; D006146:Guanidines; C116861:N'-methylniphimycin