Synthetic peptides: a modern approach to vaccination.
For induction of humoral or cell-mediated immunity, development of synthetic peptide vaccines present a novel approach and a better alternative to conventional vaccines. Construction of synthetic peptides that mimic antigenic sites is the basis of this approach. In this article various methodologies involved in the peptide synthesis are discussed. This is followed by a discussion on the strategies involved in rendering poor or non-immunogenic peptides immunogenic. These include coupling to large carrier proteins, polymeric presentation and incorporation of an identified Th cell epitope into the peptide.
Sood
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Department of Pharmaceutical Sciences, Dr H.S. Gour Vishwavidyalaya, India.
Venugopalan
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P
Mysore
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Vyas
S P
SP
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D000939:Epitopes / Q000276:immunology; D006649:Histocompatibility Antigens; D006801:Humans; D008722:Methods; D010455:Peptides / Q000138:chemical synthesis / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D014611:Vaccination / Q000639:trends*; D014614:Vaccines, Synthetic / Q000276:immunology
D000939:Epitopes; D006649:Histocompatibility Antigens; D010455:Peptides; D014614:Vaccines, Synthetic