title: Increase of decorin content in articular cartilage following running.
abstract: The effect of long distance running exercise (40 km/day for 15 weeks, five days a week) on the decorin content of articular cartilage from the knee joint was studied in female beagle dogs. Samples from load bearing sites on the lateral plateau of the tibia (TL), and pooled material from two minimum load bearing sites on the posterior section of lateral (FLP) and medial (FMP) femoral condyles were analyzed. The running exercise protocol did not lead to significant changes in the overall glycosaminoglycan content of the cartilage. However, the amount of decorin significantly increased in the TL samples, and also in the FMP pool. These results support earlier in vitro observations that decorin synthesis is stimulated by loading, independent of the synthesis of aggrecan.
authors.affiliation: Jan van Breemen Institute, Amsterdam, The Netherlands.
authors.forename: N A
authors.initials: NA
authors.lastname: Visser
authors.forename: M H
authors.initials: MH
authors.lastname: de Koning
authors.forename: M J
authors.initials: MJ
authors.lastname: Lammi
authors.forename: T
authors.initials: T
authors.lastname: Häkkinen
authors.forename: M
authors.initials: M
authors.lastname: Tammi
authors.forename: G P
authors.initials: GP
authors.lastname: van Kampen
mesh_terms: D053674:Aggrecans; D000818:Animals; D058578:Biglycan; D002358:Cartilage, Articular / Q000378:metabolism*; D058575:Decorin; D004285:Dogs; D016326:Extracellular Matrix Proteins; D005260:Female; D006025:Glycosaminoglycans / Q000378:metabolism; D037181:Lectins, C-Type; D011509:Proteoglycans / Q000378:metabolism*; D012420:Running / Q000502:physiology*
chemical_list: D053674:Aggrecans; D058578:Biglycan; D058575:Decorin; D016326:Extracellular Matrix Proteins; D006025:Glycosaminoglycans; D037181:Lectins, C-Type; D011509:Proteoglycans