Hydroindenic-guanylhydrazones. Synthesis and evaluation as inotropic agents.
The synthesis and inotropic activity of two families of hydroindenic compounds are described. Among them, a bis-guanylhydrazone derivative has demonstrated to produce an interesting positive inotropic effect on guinea pig atria, displaying at higher dosis a similar effect to that elicited by digoxin.
Melero
C P
CP
Laboratorio de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad de Salamanca, Spain.
Sevillano
L G
LG
Caballero
E
E
Tomé
F
F
Carrón
R
R
Montero
M J
MJ
San Feliciano
A
A
Medarde
M
M
D000818:Animals; D002316:Cardiotonic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D013329:Structure-Activity Relationship
D002316:Cardiotonic Agents