title: Data of pre-clinical and early clinical trials of acriflavine and hydroxy-methyl-ellipticine reviewed, enriched by the experience of their use for 18 months to 6 years in combinations with other HIV1 virostatics.
abstract: Two virostatics which we discovered in 1990, acriflavine (ACF) and hydroxy-methyl-ellipticine (HEL) and shown active on HIV1 resistant to AZT have been introduced into combinations of four virostatics selected among ten available: themselves, plus zidovudine, zalcitabine, didanosine, lamivudine, stavudine, saquinavir, ritonavir, indinavir, the combinations were applied in 3-week sequences, differing from each other by drug rotation. Those which contained ACF may have more often a CD34 decrease than those containing neither ACF nor HEL, and they present more often a CD4 increase. No significant difference as far as side effects or beneficial effects could be detected after 18 months to 6 years, between sequences containing ACF or HEL or both, and sequences not containing any one of them.
authors.affiliation: Institut de Cancérologie et d'Immunologie et Hôpital Suisse de Paris, Issy-les-Moulineaux, France.
authors.forename: G
authors.initials: G
authors.lastname: Mathé
authors.forename: K
authors.initials: K
authors.lastname: Triana
authors.forename: P
authors.initials: P
authors.lastname: Pontiggia
authors.forename: D
authors.initials: D
authors.lastname: Blanquet
authors.forename: M
authors.initials: M
authors.lastname: Hallard
authors.forename: C
authors.initials: C
authors.lastname: Morette
mesh_terms: D000167:Acriflavine / Q000627:therapeutic use*; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination; D004611:Ellipticines / Q000627:therapeutic use*; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D016896:Treatment Outcome; D015215:Zidovudine / Q000627:therapeutic use
chemical_list: D019380:Anti-HIV Agents; D004611:Ellipticines; C027767:elliptinium; D000167:Acriflavine; D015215:Zidovudine