title: Clinical and morphological characteristics in Streptococcus bovis endocarditis: a comparison with other causative microorganisms in 177 cases.
abstract: OBJECTIVE
  To compare the clinical and morphological characteristics of patients with Streptococcus bovis endocarditis with those of patients with endocarditis caused by other microorganisms.
  
  
  METHODS
  177 consecutive patients (Streptococcus bovis, 22; other streptococci, 94; staphylococci, 44; other, 17) with definite infective endocarditis according to the Duke criteria were included. All patients underwent transthoracic and transoesophageal echocardiography. In 88 patients, findings from surgery/necropsy were obtained.
  
  
  RESULTS
  S bovis endocarditis was associated with older patients, with a higher mortality (p = 0.04), and with a higher rate of cardiac surgery (p < 0.001) than other microorganisms, although embolic events were observed less often (p = 0.02). Pathological gastrointestinal lesions were detected in 45% of the patients. Multiple valves were affected in 68% of the patients with S bovis endocarditis and in 20% of those with other organisms (p < 0.001). Moderate or severe regurgitation occurred more often in S bovis endocarditis than with other microorganisms (p = 0.05). When surgery or necropsy was performed, infectious myocardial infiltration of the left ventricle was confirmed histopathologically in 36% of the patients with S bovis endocarditis and in 10% of those with other organisms (p = 0.002).
  
  
  CONCLUSIONS
  S bovis endocarditis is a severe illness because of the more common involvement of multiple valves, and of the frequent occurrence of haemodynamically relevant valvar regurgitation and infectious myocardial infiltration.
authors.affiliation: Department of Medicine II, Mainz University, Germany. kupferwasser@humc.edu
authors.forename: I
authors.initials: I
authors.lastname: Kupferwasser
authors.forename: H
authors.initials: H
authors.lastname: Darius
authors.forename: A M
authors.initials: AM
authors.lastname: Müller
authors.forename: S
authors.initials: S
authors.lastname: Mohr-Kahaly
authors.forename: T
authors.initials: T
authors.lastname: Westermeier
authors.forename: H
authors.initials: H
authors.lastname: Oelert
authors.forename: R
authors.initials: R
authors.lastname: Erbel
authors.forename: J
authors.initials: J
authors.lastname: Meyer
mesh_terms: D000328:Adult; D000368:Aged; D017548:Echocardiography, Transesophageal; D004617:Embolism / Q000382:microbiology; D004697:Endocarditis, Bacterial / Q000000981:diagnostic imaging / Q000382:microbiology* / Q000401:mortality / Q000473:pathology; D005260:Female; D005767:Gastrointestinal Diseases / Q000382:microbiology / Q000473:pathology; D006351:Heart Valves / Q000382:microbiology* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D013290:Streptococcal Infections / Q000000981:diagnostic imaging* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D016985:Streptococcus bovis