[Immunity of middle age and aged patients with tuberculosis and its changes during multimodality treatment by using T-activin].
Fifty six patients with pulmonary tuberculosis were examined. Of them 30 had T-activin in multimodality treatment. To supplement the agent in elderly and old patients was found to elevate the counts of T lymphocytes and T helper cells, to normalize Tx/Tc ratios, to enhance T lymphocytic activity and IL-2 synthesis. At the same time there was an increase in nonspecific responsiveness: enhancement of NKC activity and IL-1 synthesis by macrophages. With this, stimulation of specific antituberculous immunity took place. Normalization of immunological responsiveness and stimulation of specific antituberculous immunity were associated with enhanced therapeutical efficiency.
Adambekov
D A
DA
Litvinov
V I
VI
Mambetov
K B
KB
Koshmuratov
A G
AG
Sabyrbekova
T S
TS
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000627:therapeutic use*; D016516:CD4-CD8 Ratio / Q000187:drug effects; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007109:Immunity; D007375:Interleukin-1 / Q000096:biosynthesis / Q000097:blood; D007376:Interleukin-2 / Q000096:biosynthesis / Q000097:blood; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000627:therapeutic use*; D013949:Thymus Extracts / Q000627:therapeutic use*; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000188:drug therapy / Q000276:immunology*
D000276:Adjuvants, Immunologic; D000995:Antitubercular Agents; D007375:Interleukin-1; D007376:Interleukin-2; D010455:Peptides; D013949:Thymus Extracts; C036191:T-activin
Immunologicheskiĭ status bol'nykh tuberculezom pozhilogo i starcheskogo vozrasta i ego izmeneniia v protsesse kompleksnogo lecheniia s ispol'zovaniiem T-aktivina.