[Current results of the treatment of cervical metastatic lymph nodes by concurrent hyperfractionation of carboplatin and irradiation].
The results of the treatment of metastatic neck nodes is evaluated after a mean follow-up of 24 months (maximum 45 months). Fifty-seven patients with epidermoid carcinoma of the head and neck were treated according to a hyperfractionated chemoradiation schedule including two fractions a day. Each fraction consisted of 10 mg carboplatin + 115 cGy. Two fractions were given each day, five days a week, for a total dose of 700 mg carboplatin + 8050 cGy. Whenever possible, surgical salvage was performed if treated nodes persisted or recurred. Ten patients presented with N0, 8 with N1, 7 with N2a, 4 with N2b, 7 with N2c, and 21 with N3. The classification of the primary tumor was: 3 Tx, 6 T2, 9 T3 and 39 T4. One hundred and eleven nodes were treated (62 with a diameter of 1-3 cm, 26 with a diameter of 3-6 cm and 23 with a diameter over 6 cm). Actuarial node controls were: 100% for N0, 97% for nodes 1-3 cm, 87% for nodes 3-6 cm, 95% for nodes over 6 cm and 97% for the whole group. The actuarial local-regional control was 71% and the disease-free survival was 60%. These results include 5 surgical salvages (11% of N+), 2 of which recurred again (40%), while another 3 (60%) did not recur.
de Serdio
J L
JL
Hospital Nuestra Señora de la Candelaria, Santa Cruz de Tenerife.
Villar
A
A
Cejas
L
L
Gil
J A
JA
Alvarez
I E
IE
Martínez
J C
JC
Pérez-Suárez
M D
MD
D000368:Aged; D002277:Carcinoma / Q000188:drug therapy* / Q000532:radiotherapy* / Q000556:secondary; D002574:Cervical Vertebrae; D019583:Dose Fractionation, Radiation; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy* / Q000556:secondary; D006801:Humans; D008207:Lymphatic Metastasis; D011879:Radiotherapy Dosage
Resultados actuales del tratamiento de las adenopatías cervicales metastásicas mediante hiperfraccionamiento concurrente de carboplatino e irradiación.