Hypothalamic hamartoma: report of a case with unusual histologic features.
A rare case of hypothalamic hamartoma with unusual radiologic and histopathological features is described, possibly the first of its type in English literature. A 1.5-year-old female child presented with precocious puberty. MR scan of the brain revealed a pedunculated hypothalamic mass, most of which was isointense with normal brain on T1- and T2-weighted images. However, a sizeable component of the lesion was hyperintense on T1-weighted images, suggestive of adipose tissue. Microscopically, the lesion was a hamartoma composed of an admixture of neuroectodermal elements, namely glial cells, neurons, and nerve bundles along with mesenchymal elements in the form of fibroadipose tissue.
Sharma
M C
MC
Department of Pathology, All India Institute of Medical Sciences, New Delhi.
Gaikwad
S
S
Mahapatra
A K
AK
Menon
P S
PS
Sarkar
C
C
D001927:Brain Diseases / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006222:Hamartoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D007124:Immunoenzyme Techniques; D007223:Infant; D008279:Magnetic Resonance Imaging; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D011629:Puberty, Precocious / Q000209:etiology; D009418:S100 Proteins / Q000378:metabolism; D016708:Synaptophysin / Q000378:metabolism
D005904:Glial Fibrillary Acidic Protein; D009418:S100 Proteins; D016708:Synaptophysin; D010751:Phosphopyruvate Hydratase