title: Free D- and L-amino acids in ventricular cerebrospinal fluid from Alzheimer and normal subjects.
abstract: Free D-Ser, D-Asp and total D-amino acids were significantly higher (p < 0.05) in Alzheimer (AD) ventricular CSF than in normal CSF. There was no significant difference in the total L-amino acids between AD and normal CSF, but L-Gln and L-His were significantly higher (p < 0.05) in AD-CSF. The higher concentrations of these D- and L-amino acids in AD ventricular CSF could reflect the degenerative process that occurs in Alzheimer's brain since ventricular CSF is the repository of amino acids from the brain.
authors.affiliation: Department of Chemistry, Barry University, Miami Shores, Florida, USA.
authors.forename: G
authors.initials: G
authors.lastname: Fisher
authors.forename: N
authors.initials: N
authors.lastname: Lorenzo
authors.forename: H
authors.initials: H
authors.lastname: Abe
authors.forename: E
authors.initials: E
authors.lastname: Fujita
authors.forename: W H
authors.initials: WH
authors.lastname: Frey
authors.forename: C
authors.initials: C
authors.lastname: Emory
authors.forename: M M
authors.initials: MM
authors.lastname: Di Fiore
authors.forename: A
authors.initials: A
authors.lastname: D' Aniello
mesh_terms: D000544:Alzheimer Disease / Q000134:cerebrospinal fluid*; D000596:Amino Acids / Q000134:cerebrospinal fluid*; D006801:Humans
chemical_list: D000596:Amino Acids