[Comparative activity of cefepime, ceftazidime and imipenem in a mouse infection caused by Klebsiella pneumoniae producing a broad spectrum beta-lactamase].
Mice experimentally infected with extended-spectrum beta-lactamase-producing Klebsiella pneumoniae strains were injected twice daily for three days with ceftazidime, cefepime, or imipenem (25, 50, or 100 mg/kg/injection). Treatment efficacy was based on five-day survival and on the spleen viable bacteria count 16 hours after the last treatment dose. Under these experimental conditions, ceftazidime showed some activity on strains with low levels of resistance to ceftazidime. Cefepime used in a dose of 50 or 100 mg per injection demonstrated good activity but was slightly less effective than imipenem.
Ronco
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E
Faculté de Médecine de Paris-Ouest, Université Paris V, Garches, France.
Lawrence
C
C
Nauciel
C
C
D000818:Animals; D000077723:Cefepime; D002442:Ceftazidime / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D015169:Colony Count, Microbial; D015378:Imipenem / Q000627:therapeutic use*; D007710:Klebsiella Infections / Q000188:drug therapy* / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000201:enzymology* / Q000302:isolation & purification; D051379:Mice; D008826:Microbial Sensitivity Tests; D013154:Spleen / Q000382:microbiology; D013845:Thienamycins / Q000627:therapeutic use; D001618:beta-Lactamases / Q000378:metabolism*
D002511:Cephalosporins; D013845:Thienamycins; D015378:Imipenem; D000077723:Cefepime; D002442:Ceftazidime; D001618:beta-Lactamases
Activité comparée du céfépime, de la ceftazidime et de l'imipénème lors d'une infection de la souris par Klebsiella pneumoniae productrice de beta-lactamase à spectre élargi.