Epoxyalkanoyls as novel ACE inhibitors.
The epoxyalkanoyl derivatives were designed and synthesized as ACE inhibitors. Coupling of unsaturated carboxylic acids with amino acids and following epoxidation with dimethyldioxirane gave the epoxyalkanoyls with high yield. The inhibitory activity of synthesized compounds on angiotensin converting enzyme was IC50 values of 0.06-5.5 microM.
Choo
H Y
HY
School of Pharmacy, Ewha Womans University, Seoul, Korea.
Yoon
H R
HR
Park
H S
HS
Kim
D H
DH
Park
J
J
Kim
D H
DH
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D001665:Binding Sites; D004852:Epoxy Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D007703:Peptidyl-Dipeptidase A / Q000737:chemistry; D013055:Spectrophotometry, Infrared
D000806:Angiotensin-Converting Enzyme Inhibitors; D004852:Epoxy Compounds; D007703:Peptidyl-Dipeptidase A