An alternative synthesis of 4,4-dimethyl-5 alpha-cholesta-8,14,24-trien-3 beta-ol, an intermediate in sterol biosynthesis and a reported activator of meiosis and of nuclear orphan receptor LXR alpha.
4,4-dimethyl-5 alpha-cholesta-8,14,24-trien-3 beta-ol, a sterol of current biological interest, has been synthesized in six steps from 3 beta-acetoxy-4,4-dimethyl-5 alpha-cholest-8(14)-en-15-one.
Ruan
B
B
Department of Chemistry, Rice University, Houston, TX 77251-1892, USA.
Wilson
W K
WK
Schroepfer
G J
GJ
D002782:Cholestenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004268:DNA-Binding Proteins; D000071518:Liver X Receptors; D008540:Meiosis / Q000187:drug effects*; D057093:Orphan Nuclear Receptors; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D013261:Sterols / Q000096:biosynthesis*
D002782:Cholestenes; D004268:DNA-Binding Proteins; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D018160:Receptors, Cytoplasmic and Nuclear; D013261:Sterols; C100324:4,4-dimethylcholesta-8,14,24-trienol