title: Synthesis of aryl semicarbazone of 4-aminoacetophenone and their anti-HIV activity.
abstract: The thioureido derivative of 4-aminoacetophenone aryl semicarbazone have been prepared. These derivatives have been characterised on the basis of different physicochemical evidences. The anti-HIV-1 (HTLV-IIIB) and -HIV-2 (ROD) activity and cytotoxicity of the compounds were tested. The compound VII and VIII showed maximum protection among the series.
authors.affiliation: Department of Applied Chemistry, Institute of Technology, Banaras Hindu University, Varanasi, India.
authors.forename: V
authors.initials: V
authors.lastname: Mishra
authors.forename: S N
authors.initials: SN
authors.lastname: Pandeya
authors.forename: E
authors.initials: E
authors.lastname: DeClercq
authors.forename: C
authors.initials: C
authors.lastname: Pannecouque
authors.forename: M
authors.initials: M
authors.lastname: Witvrouw
mesh_terms: D000098:Acetophenones / Q000138:chemical synthesis* / Q000494:pharmacology*; D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002461:Cell Line, Transformed; D015497:HIV-1 / Q000187:drug effects; D015498:HIV-2 / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008826:Microbial Sensitivity Tests; D012664:Semicarbazones / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000098:Acetophenones; D019380:Anti-HIV Agents; D012664:Semicarbazones; C032065:4-aminoacetophenone