In vitro inhibitory effects of DNA topoisomerase II by fernane-type triterpenoids isolated from a Euphorbia genus.
Several kinds of naturally occurring fernane-type triterpenoids isolated from a Euphorbia genus were tested on the inhibitory effects of DNA Topoisomerases I (Topo I) and II (Topo II) activities. A-ring cleaved 3,4-seco-8 beta H-ferna-4(23),9(11)-dien-3-oic acid and its 3-hydroxyl derivative were found to be selective inhibitors of Topo II activity without the stabilization of a DNA/Topo II cleavable complex.
Wada
S
S
Osaka University of Pharmaceutical Sciences, Japan.
Tanaka
R
R
Iida
A
A
Matsunaga
S
S
D004247:DNA / Q000187:drug effects / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D005047:Etoposide / Q000494:pharmacology; D019665:Euphorbiaceae / Q000737:chemistry; D019384:Nucleic Acid Synthesis Inhibitors / Q000494:pharmacology; D059005:Topoisomerase II Inhibitors; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D019384:Nucleic Acid Synthesis Inhibitors; D059005:Topoisomerase II Inhibitors; D014315:Triterpenes; D005047:Etoposide; D004247:DNA