title: Light-scattering method in particle size analysis of parenteral emulsions.
abstract: The use of a light-scattering particle size distribution analyzer has been shown to be a convenient method for characterizing the particle size distribution of parenteral emulsions. However, the concentrations of the samples used were found to have a major impact on the particle size distribution results, particularly for samples with a mean particle size smaller than 0.2 micron. An increase in sample concentration caused a shift to smaller particle sizes as a result of multiple scattering. The blue-light (tungsten lamp) intensity, instead of the He-Ne laser integrity, should be used to control sample concentration within the optimal range for measurement.
authors.affiliation: Hospital Products Division, Abbott Laboratories, Abbott Park, Illinois 60064-3500, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Tian
authors.forename: L C
authors.initials: LC
authors.lastname: Li
mesh_terms: D004655:Emulsions; D007263:Infusions, Parenteral; D007834:Lasers; D008027:Light; D010316:Particle Size; D012542:Scattering, Radiation
chemical_list: D004655:Emulsions