Targeting the shikimate pathway in the malaria parasite Plasmodium falciparum.
The shikimate pathway presents an attractive target for malaria chemotherapy. Three shikimic acid analogs exhibited different effects on Plasmodium falciparum growth. (6R)-6-Fluoro-shikimate and (6S)-6-fluoro-shikimate inhibited growth (50% inhibitory concentrations, 1.5 x 10(-5) and 2.7 x 10(-4) M, respectively), whereas 2-fluoro-shikimate had no effect. para-Aminobenzoic acid abrogated the inhibition, demonstrating that the shikimate pathway was specifically targeted.
McConkey
G A
GA
Department of Biology, University of Leeds, Leeds LS2 9JT, United Kingdom. g.a.mcconkey@leeds.ac.uk
D010129:4-Aminobenzoic Acid / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D012765:Shikimic Acid / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000494:pharmacology; D013237:Stereoisomerism
C117868:2-fluoroshikimic acid; C087313:6-fluoroshikimic acid; D000962:Antimalarials; D012765:Shikimic Acid; D010129:4-Aminobenzoic Acid