[A new benzoquinone-containing antimetastatic product].
An orally applicable fermentation product of wheat germ containing 0.04% substituted benzoquinone (MSC) was invented by Hungarian chemists under the trade--name of AVEMAR. The following biological effects of this product were observed. Oral administration (3 g/kg body weight) of MSC enhances blastic transformation of splenic lymphocytes of mice. The same treatment shortens the survival time of skin grafts in co-isogenic mouse skin transplantation model, which points to immune-reconstructive effect of MSC. Highly significant anti-metastatic effect of MSC was observed in three metastasis models (3LL-HH, B16, HCR-25). The antimetastatic activity of MSC--besides the immune reconstitution--may also due to the cell-adhesion inhibitory, cell proliferation inhibitory, apoptosis-enhancing and antioxidant effects, which were also observed in our in vitro experiments. Based on the biological effects of MSC--which is non-toxic, according to subacute toxicology studies--this product may be used as an adjuvant in the therapy of malignant neoplasia and other diseases caused by or following immunedeprivation.
Szende
B
B
I. Patológiai és Kísérleti Rákkutató Intézet, Semmelweis Orvostudományi Egyetem, Budapest.
Rásó
E
E
Hidvégi
M
M
Tömösköziné
F R
FR
Paku
S
S
Prónai
L
L
Bocsi
J
J
Lapis
K
K
D000284:Administration, Oral; D000818:Animals; D017209:Apoptosis; D016227:Benzoquinones / Q000008:administration & dosage*; D004195:Disease Models, Animal; D066298:In Vitro Techniques; D051379:Mice; D009362:Neoplasm Metastasis / Q000188:drug therapy / Q000517:prevention & control*; D015996:Survival Rate
D016227:Benzoquinones
Egy új, szubsztituált benzokinon tartalmú antimetasztatikus készítmény.