[The effect of linoleyl hydroxamic acid on lipid peroxidation processes and on the enzymatic activity of the antioxidant system in rats under hypoxia].
It was studied the effect of new blocker of lipoxygenase way of arachidontic acid metabolism--linoleyl-hydroxamic acid--on the status of lipid peroxidation and antioxidant system in blood, heart, liver, lung and brain in rats under acute hypoxic hypoxia. It was shows that preliminary introduction of this substance lead to increase of antioxidant enzymes activity--superoxide dismutase and ceruloplasmine, and to decrease of lipid peroxidation level during hypoxia in blood, heart, liver and lung (without brain).
Kukoba
T V
TV
O. O. Bogomoletz Institute of Physiology, Ukrainian National Academy of Sciences.
Seredenko
M M
MM
Butovych
I A
IA
Moĭbenko
O O
OO
D000208:Acute Disease; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002570:Ceruloplasmin / Q000187:drug effects / Q000378:metabolism; D006877:Hydroxamic Acids / Q000494:pharmacology*; D000860:Hypoxia / Q000378:metabolism*; D008041:Linoleic Acids / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008054:Lipid Peroxides / Q000378:metabolism; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000187:drug effects / Q000378:metabolism
D000975:Antioxidants; D006877:Hydroxamic Acids; D008041:Linoleic Acids; D008054:Lipid Peroxides; D016859:Lipoxygenase Inhibitors; C089594:linoleic acid hydroxamate; D013482:Superoxide Dismutase; D002570:Ceruloplasmin
Vplyv linoleïl-hidroksamovoï kysloty na stan protsesiv perekysnoho okyslennia lipidiv ta aktyvnist' fermentiv antyoksydantnoï systemy shchuriv pry hipoksiï.