Investigations of azapeptides as mimetics of Leu-enkephalin.
Solution syntheses of azapeptide pentamers 2, 3, and 4 were accomplished. The binding affinity of these azapeptides and azatide 1 were examined in the context of monoclonal antibody 3-E7 known to strongly bind the [Leu5]enkephalin sequence.
Han
H
H
Department of Chemistry, Scripps Research Institute, La Jolla, CA, USA.
Yoon
J
J
Janda
K D
KD
D004743:Enkephalin, Leucine / Q000737:chemistry* / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D018716:Molecular Mimicry; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000276:immunology; D011485:Protein Binding
D009842:Oligopeptides; D004743:Enkephalin, Leucine