title: Poor response rate to a continuous schedule of Amifostine therapy for 'low/intermediate risk' myelodysplastic patients.
abstract: Ineffective haemopoiesis leading to cytopenia presents the major clinical management problem for patients with myelodysplasia (MDS). Preliminary studies have demonstrated that the synthetic aminothiol Amifostine stimulates multilineage haemopoiesis both in vitro and in vivo in patients with MDS. We have treated 12 patients with an uninterrupted 8-week schedule of thrice-weekly intravenous Amifostine with a starting dose of 300 mg/m2 escalating to 450 mg/m2 in non-responders. No patients satisfied response criteria on study but two patients showed minor responses. We conclude that therapeutic response to Amifostine in MDS may be schedule dependent.
authors.affiliation: Ninewells Hospital, Dundee, Scotland.
authors.forename: D T
authors.initials: DT
authors.lastname: Bowen
authors.forename: C
authors.initials: C
authors.lastname: Denzlinger
authors.forename: W
authors.initials: W
authors.lastname: Brugger
authors.forename: D
authors.initials: D
authors.lastname: Culligan
authors.forename: K
authors.initials: K
authors.lastname: Gelly
authors.forename: S
authors.initials: S
authors.lastname: Adlakha
authors.forename: M
authors.initials: M
authors.lastname: Groves
authors.forename: M
authors.initials: M
authors.lastname: Hepburn
authors.forename: L
authors.initials: L
authors.lastname: Kanz
mesh_terms: D004999:Amifostine / Q000009:adverse effects / Q000627:therapeutic use*; D004797:Enzyme-Linked Immunosorbent Assay; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000473:pathology; D006801:Humans; D009190:Myelodysplastic Syndromes / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D011837:Radiation-Protective Agents; D014409:Tumor Necrosis Factor-alpha; D004999:Amifostine