title: Applications of Raman spectroscopy to ophthalmology: spectroscopic characterization of disposable soft contact lenses.
abstract: Disposable soft contact lenses based on HEMA-MAA hydrogels are examined using Raman and ATR/FTIR vibrational spectroscopies and thermal analysis. The main factors dealing with physical, chemical, and biological biocompatibility are evaluated in relation to those of long-wear soft contact lenses with the aim of individuating the most biocompatible lens. The Raman spectra of HEMA-MAA lenses show that some biocompatibility factors are affected by environmental conditions and, in particular, by changes in pH and ionic strength values.
authors.affiliation: Centro di Studio sulla Spettroscopia Raman, Dipartimento di Biochimica G. Moruzzi, Università di Bologna, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Monti
authors.forename: R
authors.initials: R
authors.lastname: Simoni
authors.forename: R
authors.initials: R
authors.lastname: Caramazza
authors.forename: A
authors.initials: A
authors.lastname: Bertoluzza
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D002021:Buffers; D018639:Contact Lens Solutions; D003263:Contact Lenses, Hydrophilic; D004055:Differential Thermal Analysis; D004209:Disposable Equipment; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009994:Osmolar Concentration; D012965:Sodium Chloride; D013055:Spectrophotometry, Infrared; D013059:Spectrum Analysis, Raman / Q000379:methods*; D013997:Time Factors; D014867:Water
chemical_list: D001672:Biocompatible Materials; D002021:Buffers; D018639:Contact Lens Solutions; D014867:Water; D012965:Sodium Chloride