title: A case of myokymia-cramp syndrome successfully treated with gabapentin.
abstract: We report a case of "myokymia-cramp syndrome", a rare and benign disease consisting of muscular cramps in the upper and lower limbs associated with generalized myokymias. In our patient, cramps had been present since adolescence and had increased in frequency and duration during the last 3 years, occurring about 8 or 9 times a day. Cramps were mainly nocturnal and also precipitated by walking; a previous treatment with carbamazepine did not improve the symptoms. Gabapentin therapy proved to be very satisfactory in relieving muscular cramps with a relatively low dosage (600 mg/day) and without any remarkable side effects. The possible interpretation of the mechanism involved in gabapentin induced relief of cramps is discussed. Gabapentin should be considered as a safe alternative treatment for muscular cramps.
authors.affiliation: Istituto di Clinica delle Malattie Nervose e Mentali, Università La Sapienza, Roma, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Serrao
authors.forename: P
authors.initials: P
authors.lastname: Cardinali
authors.forename: P
authors.initials: P
authors.lastname: Rossi
authors.forename: L
authors.initials: L
authors.lastname: Parisi
authors.forename: R
authors.initials: R
authors.lastname: Tramutoli
authors.forename: F
authors.initials: F
authors.lastname: Pierelli
mesh_terms: D000085:Acetates / Q000627:therapeutic use*; D000588:Amines; D003509:Cyclohexanecarboxylic Acids; D005121:Extremities; D005207:Fasciculation / Q000188:drug therapy*; D000077206:Gabapentin; D006801:Humans; D008297:Male; D008875:Middle Aged; D009120:Muscle Cramp / Q000188:drug therapy*; D013577:Syndrome; D016896:Treatment Outcome; D005680:gamma-Aminobutyric Acid
chemical_list: D000085:Acetates; D000588:Amines; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin