title: Solid phase synthesis of N-carboxy alkyl-containing peptides derived from enantiopure alpha-keto-beta-aminoacids.
abstract: alpha-Keto-beta-aminoacids 5a-c can be reductively aminated with the peptide sequence H2N-Leu-Val-Phe-Phe on a solid support to afford N-carboxy alkyl peptides 1a-c. The N-carboxy alkyl lysine derivative 7 was subsequently extended from the N-terminus with glutamine and histidine residues.
authors.affiliation: School of Chemistry, Queen's University, Belfast, UK.
authors.forename: C
authors.initials: C
authors.lastname: Fernández-García
authors.forename: K
authors.initials: K
authors.lastname: Prager
authors.forename: M A
authors.initials: MA
authors.lastname: McKervey
authors.forename: B
authors.initials: B
authors.lastname: Walker
authors.forename: C H
authors.initials: CH
authors.lastname: Williams
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D010455:Peptides