title: Neuroendocrine carcinoma of the extrahepatic biliary tract with positive immunostaining for gastrin-releasing peptide: report of a case.
abstract: We report herein the first documented case of gastrin-releasing peptide-positive neuroendocrine (NE) carcinoma of the extrahepatic biliary tract. An invasive tumor measuring 2.5 x 1.5 cm was located in the confluence portion of the cystic duct in a 70-year-old Japanese man. Histologically, the tumor was found to be composed of small polygonal cells which formed a solid and trabecular structure, and the frequencies of both mitoses and small necrotic areas were dominant. The tumor cells were immunoreactive to the NE markers chromogranin-A and neuron-specific enolase, as well as to carcinoembryonic antigen and gastrin-releasing peptide. Although a few cases of gastrin-releasing peptide-positive small-cell lung carcinoma have been documented, there have been no reports of gastrin-releasing peptide-positive NE carcinoma occurring in the gastrointestinal tract. We consider our case not merely to be of pathological interest, but also to have clinical and therapeutic implications.
authors.affiliation: Department of Surgery 1, Sapporo Medical University, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Oikawa
authors.forename: K
authors.initials: K
authors.lastname: Hirata
authors.forename: T
authors.initials: T
authors.lastname: Katsuramaki
authors.forename: M
authors.initials: M
authors.lastname: Mukaiya
authors.forename: K
authors.initials: K
authors.lastname: Sasaki
authors.forename: M
authors.initials: M
authors.lastname: Satoh
mesh_terms: D000368:Aged; D001650:Bile Duct Neoplasms / Q000378:metabolism* / Q000473:pathology; D017734:Bile Ducts, Extrahepatic; D018278:Carcinoma, Neuroendocrine / Q000378:metabolism* / Q000473:pathology; D053379:Chromogranin A; D002864:Chromogranins; D017809:Fatal Outcome; D019886:Gastrin-Releasing Peptide / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D010751:Phosphopyruvate Hydratase
chemical_list: D053379:Chromogranin A; D002864:Chromogranins; D019886:Gastrin-Releasing Peptide; D010751:Phosphopyruvate Hydratase