title: A patient homozygous for mutation 20210A in the prothrombin gene with venous thrombosis and transient ischemic attacks of thrombotic origin.
abstract: It is well established that genetic disorders interact with environmental factors to cause thrombotic diseases. Therefore, antithrombin, protein C, protein S deficiencies and the more recently described factor V Leiden and prothrombin mutations are currently been investigated to explain some thrombophilic states. We report the case of a 63-year-old man who developed two transient ischemic attacks and two years later an extensive femoro-iliac venous thrombosis. He was genotyped as FV R506Q negative and FII G20210A positive in homozygous state (FII 20210AA).
authors.forename: A J
authors.initials: AJ
authors.lastname: González Ordóñez
authors.forename: J M
authors.initials: JM
authors.lastname: Medina Rodriguez
authors.forename: C R
authors.initials: CR
authors.lastname: Fernández Alvarez
authors.forename: M D
authors.initials: MD
authors.lastname: Macias Robles
authors.forename: E
authors.initials: E
authors.lastname: Coto García
mesh_terms: D000368:Aged; D004252:DNA Mutational Analysis; D006801:Humans; D002546:Ischemic Attack, Transient / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D017354:Point Mutation; D011516:Prothrombin / Q000235:genetics*; D012306:Risk; D019851:Thrombophilia / Q000453:epidemiology / Q000235:genetics*; D013924:Thrombophlebitis / Q000453:epidemiology / Q000235:genetics*
chemical_list: D011516:Prothrombin