P2-proline-derived inhibitors of calpain I.
The syntheses and biological activities of a series of calpain I inhibitors, derived from D- and L-Pro, are described.
Tripathy
R
R
Department of Chemistry, Cephalon, Inc., West Chester, PA 19380-4245, USA.
Gu
Z Q
ZQ
Dunn
D
D
Senadhi
S E
SE
Ator
M A
MA
Chatterjee
S
S
D002154:Calpain / Q000037:antagonists & inhibitors*; D015853:Cysteine Proteinase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D011392:Proline / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D015853:Cysteine Proteinase Inhibitors; D011392:Proline; D002154:Calpain