Derivatization of soyasapogenol A and their hepatoprotective activities.
Fifteen derivatives of soyasapogenol A (1), which is another aglycon moiety of soyasaponins from soybean together with soyasapogenol B (2), were prepared and their in vitro hepatoprotective effects were evaluated.
Sasaki
K
K
Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., Yokohama, Japan.
Minowa
N
N
Kuzuhara
H
H
Nishiyama
S
S
Omoto
S
S
D002478:Cells, Cultured; D006801:Humans; D008099:Liver / Q000187:drug effects*; D008956:Models, Chemical; D008958:Models, Molecular; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D013025:Glycine max; D013329:Structure-Activity Relationship
D010936:Plant Extracts; C116604:soyasapogenol A; D009828:Oleanolic Acid