title: Early pulmonary lesions in turkeys produced by nonviable Aspergillus fumigatus and/or Pasteurella multocida lipopolysaccharide.
abstract: This study assessed the potential of lipopolysaccharide (LPS) purified from Pasteurella multocida to cause pulmonary pathology or exacerbate lesions produced by gamma-irradiated nonviable Aspergillus fumigatus conidia when administered via the intra-air sac route in turkeys. LPS provoked suppurative airsacculitis, pleuritis, and pneumonia. Nonviable conidia produced airsacculitis and transient pneumonitis but did not elicit multinucleate giant cells, which are a feature of the inflammatory process in A. fumigatus infection. LPS in combination with A. fumigatus conidia resulted in accelerated pulmonary inflammation and apparently delayed clearance of conidia from pulmonary tissues. This study presents a model of aseptic airsacculitis and pneumonia with clinical relevance.
authors.affiliation: Avian and Swine Respiratory Diseases Research Unit, United States Department of Agriculture, National Animal Disease Center, Ames, IA 50010, USA.
authors.forename: R A
authors.initials: RA
authors.lastname: Kunkle
authors.forename: R B
authors.initials: RB
authors.lastname: Rimler
mesh_terms: D000400:Air Sacs / Q000382:microbiology; D000818:Animals; D001228:Aspergillosis / Q000473:pathology / Q000662:veterinary; D001232:Aspergillus fumigatus / Q000276:immunology*; D007249:Inflammation; D008070:Lipopolysaccharides / Q000633:toxicity*; D008168:Lung / Q000187:drug effects / Q000473:pathology*; D008172:Lung Diseases, Fungal / Q000473:pathology / Q000662:veterinary; D010326:Pasteurella Infections / Q000473:pathology / Q000662:veterinary; D016979:Pasteurella multocida / Q000276:immunology*; D010998:Pleurisy / Q000382:microbiology / Q000473:pathology / Q000662:veterinary; D018410:Pneumonia, Bacterial / Q000382:microbiology / Q000473:pathology / Q000662:veterinary; D011201:Poultry Diseases / Q000382:microbiology / Q000473:pathology; D014422:Turkeys
chemical_list: D008070:Lipopolysaccharides