title: Bone scan and bone biopsy in the detection of skeletal metastases.
abstract: This study provides the first quantitative indication of the limits of sensitivity of a bone scan with technetium (99Tc-MDP) in detecting skeletal metastases and thereby also helps to explain the fact that bone scans may be negative when metastases are present in the bone marrow. Since 99Tc-MDP remains the least noxious and most widely used isotope for bone scanning, these results have direct clinical relevance in the evaluation of patients with solid tumors and possible metastatic spread.
authors.affiliation: Department of Oncology, Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel.
authors.forename: I G
authors.initials: IG
authors.lastname: Ron
authors.forename: A
authors.initials: A
authors.lastname: Striecker
authors.forename: H
authors.initials: H
authors.lastname: Lerman
authors.forename: A
authors.initials: A
authors.lastname: Bar-Am
authors.forename: B
authors.initials: B
authors.lastname: Frisch
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy / Q000009:adverse effects; D001853:Bone Marrow / Q000000981:diagnostic imaging / Q000473:pathology; D001856:Bone Marrow Examination; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary*; D004311:Double-Blind Method; D005069:Evaluation Studies as Topic; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D007085:Ilium / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D013669:Technetium Tc 99m Medronate; D013997:Time Factors
chemical_list: D013669:Technetium Tc 99m Medronate