title: Enzymatic fucosylations of non-natural sialylated type-I trisaccharides with recombinant fucosyl-transferase-III.
abstract: Recombinant fucosyl-transferase-III (Lewis type enzyme) is used to prepare a series of non-natural sialyl-Lewis derivatives on a preparative scale. The enzyme tolerates a wide range of acceptors which have the natural N-acetyl group of the glucosamine moiety replaced by substituted aromatic and heteroaromatic amides.
authors.affiliation: Novartis Pharma AG, Basle, Switzerland.
authors.forename: G
authors.initials: G
authors.lastname: Baisch
authors.forename: R
authors.initials: R
authors.lastname: Ohrlein
authors.forename: M
authors.initials: M
authors.lastname: Streiff
mesh_terms: D002240:Carbohydrate Sequence; D005647:Fucosyltransferases / Q000737:chemistry*; D008969:Molecular Sequence Data; D019158:N-Acetylneuraminic Acid / Q000737:chemistry*; D009844:Oligosaccharides / Q000737:chemistry*; D011994:Recombinant Proteins / Q000737:chemistry
chemical_list: D009844:Oligosaccharides; D011994:Recombinant Proteins; D005647:Fucosyltransferases; C019818:3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase; D019158:N-Acetylneuraminic Acid