Pyrrolnitrin and related pyrroles endowed with antibacterial activities against Mycobacterium tuberculosis.
During development of nitroheterocycles with potential antimycobacterial activities we have tested against Mycobacterium tuberculosis a number of pyrroles strictly related to pyrrolnitrin, an antifungal antibiotic isolated from Streptomyces pyrrocinia. Some of the tested arylpyrrole derivatives and pyrrolnitrin have shown appreciable inhibiting activity against M. tuberculosis and M. avium. SAR studies well correlate antimycobacterial potency with the presence of halogens in the phenyl ring and a nitro group at position 3 of pyrrole.
Di Santo
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Dipartimento di Studi Farmaceutici, Università di Roma La Sapienza, Italy.
Costi
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R
Artico
M
M
Massa
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S
Lampis
G
G
Deidda
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D
Pompei
R
R
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents / Q000494:pharmacology; D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D004359:Drug Therapy, Combination / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D011758:Pyrroles / Q000138:chemical synthesis / Q000494:pharmacology*; D011764:Pyrrolnitrin / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000995:Antitubercular Agents; D011758:Pyrroles; D011764:Pyrrolnitrin