title: Acute autoimmune sensorineural hearing loss associated with Crohn's disease.
abstract: We report the sudden onset of bilateral hearing loss in a patient with Crohn's disease while the intestinal disease was quiescent. Antibodies directed against collagen type II were detected in the serum. Dramatic improvement of his hearing was observed under corticosteroid therapy. Diagnosis of autoimmune sensorineural hearing loss was established. This condition could be considered as an extraintestinal manifestation of Crohn's disease. Early diagnosis is mandated, as prompt and intensive treatment with corticosteroids and/or immunosuppressive drugs is effective and could prevent irreversible hearing loss.
authors.affiliation: Department of Internal Medicine, Laennec Hospital, Creil, France.
authors.forename: C
authors.initials: C
authors.lastname: Bachmeyer
authors.forename: N
authors.initials: N
authors.lastname: Leclerc-Landgraf
authors.forename: F
authors.initials: F
authors.lastname: Laurette
authors.forename: P
authors.initials: P
authors.lastname: Coutarel
authors.forename: J F
authors.initials: JF
authors.lastname: Cadranel
authors.forename: J
authors.initials: J
authors.lastname: Médioni
authors.forename: R
authors.initials: R
authors.lastname: Dhôte
authors.forename: M
authors.initials: M
authors.lastname: Mougeot-Martin
mesh_terms: D000208:Acute Disease; D000328:Adult; D001299:Audiometry; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D003424:Crohn Disease / Q000150:complications* / Q000188:drug therapy; D005938:Glucocorticoids / Q000627:therapeutic use; D006319:Hearing Loss, Sensorineural / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D011241:Prednisone / Q000627:therapeutic use
chemical_list: D005938:Glucocorticoids; D011241:Prednisone