Reduction of platelet phospholipase C-delta1 activity in Alzheimer's disease associated with a specific apolipoprotein E genotype (epsilon3/epsilon3).
The epsilon4 allele of apolipoprotein E (apo E) is increased among patients with sporadic or familial Alzheimer's disease (AD). We examined platelet phospholipase C (PLC)-delta1 activity in AD patients either homozygous for apoepsilon3 or having at least one apo epsilon4 allele. We found that platelet PLC-delta1 activity is reduced from control levels in patients homozygous for apo epsilon3, but not changed in patients with an apo epilson4 allele. Reduced PLC-delta1 activity and apo epsilon3 may contribute to AD pathogenesis apart from the apo epsilon4 allele.
Matsushima
H
H
Department of Neurology, Faculty of Medicine, Kyoto University, Sakyoku, Kyoto 606, Japan.
Shimohama
S
S
Kawamata
J
J
Fujimoto
S
S
Takenawa
T
T
Kimura
J
J
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000201:enzymology* / Q000235:genetics; D053318:Apolipoprotein E3; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics / Q000378:metabolism*; D001792:Blood Platelets / Q000201:enzymology*; D005260:Female; D005838:Genotype; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism*; D008297:Male; D010084:Oxidation-Reduction; D054803:Phospholipase C delta; D010738:Type C Phospholipases / Q000378:metabolism*
D053318:Apolipoprotein E3; D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D007527:Isoenzymes; D010738:Type C Phospholipases; C518024:PLCD1 protein, human; D054803:Phospholipase C delta