Synthesis of Dolastatin 15 mimetic peptoids.
Eight peptoids have been synthesized as peptidomimetics of the cytostatic Dolastatin 15, a depsipeptide isolated from the Indian sea hare Dolabella auricularia. The compounds have been tested against several human cancer cell lines and did not show any cytostatic properties.
Schmitt
J
J
Institut für Organische Chemie und Biochemie Technischen Universität München, Garching, Germany.
Bernd
M
M
Kutscher
B
B
Kessler
H
H
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D047630:Depsipeptides; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D018716:Molecular Mimicry; D009842:Oligopeptides / Q000737:chemistry* / Q000494:pharmacology; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D034444:Peptoids; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D047630:Depsipeptides; D009842:Oligopeptides; D010455:Peptides; D034444:Peptoids; C075610:dolastatin 15