title: Pharyngo-laryngeal histoplasmosis: one case in an immunocompetent child.
abstract: We report a very rare case of disseminated pharyngo-laryngeal histoplasmosis with systemic spread in a 10-year-old, immunocompetent child from Guyana. The main signs were a marked deterioration in his general condition, hepato-splenomegaly, multiple lymphadenopathy and ulcerated pharyngo-laryngeal lesions. The diagnosis was made from brushings of the ulcerative lesions, a lymph node biopsy and serological tests performed in the national reference center for histoplasmosis. The initial treatment was with amphotericin B, which was then replaced by oral itraconazole. We report here the main epidemiological, clinical and therapeutic characteristics.
authors.affiliation: Department of Pediatric ENT and Cervico-Facial Surgery, Trousseau Children's Hospital, Paris, France. orl.trousseau@trs.ap-hop-paris.fr
authors.forename: T
authors.initials: T
authors.lastname: Coiffier
authors.forename: G
authors.initials: G
authors.lastname: Roger
authors.forename: L
authors.initials: L
authors.lastname: Beust
authors.forename: B
authors.initials: B
authors.lastname: Quinet
authors.forename: D
authors.initials: D
authors.lastname: Adam
authors.forename: B
authors.initials: B
authors.lastname: Dupont
authors.forename: E N
authors.initials: EN
authors.lastname: Garabedian
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D002648:Child; D006172:Guyana / Q000208:ethnology; D006660:Histoplasmosis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D007818:Laryngeal Diseases / Q000382:microbiology*; D008297:Male; D010297:Paris / Q000453:epidemiology; D010608:Pharyngeal Diseases / Q000382:microbiology*
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B