title: Phycomysterols and other sterols from the fungus Phycomyces blakesleeanus.
abstract: In the search for novel bioactive products from filamentous fungi, sterols and triterpenoids found in Phycomyces blakesleeanus were analyzed using semipreparative HPLC, GC-MS, and NMR techniques. Structures proposed for the three new compounds identified, phycomysterol A (1), phycomysterol B (2), and neoergosterol (3), were confirmed by chemical synthesis. Phycomysterols possess a new natural 19-norergostane skeleton with an aromatic B ring. Phycomysterol A showed anti-HIV activity.
authors.affiliation: Departamento de Química Orgánica, Instituto de Biotecnología, Facultad de Ciencias, Universidad de Granada, Campus Fuentenueva s/n, 18071 Granada, Spain.afbarre@golit.ugr.es
authors.forename: A F
authors.initials: AF
authors.lastname: Barrero
authors.forename: J E
authors.initials: JE
authors.lastname: Oltra
authors.forename: J A
authors.initials: JA
authors.lastname: Poyatos
authors.forename: D
authors.initials: D
authors.lastname: Jiménez
authors.forename: E
authors.initials: E
authors.lastname: Oliver
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002478:Cells, Cultured; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D051379:Mice; D010800:Phycomyces / Q000737:chemistry*; D013261:Sterols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D010948:Viral Plaque Assay
chemical_list: D019380:Anti-HIV Agents; D000970:Antineoplastic Agents; D013261:Sterols