title: Phthalimidomethyl as a drug pro-moiety. Probing its reactivity.
abstract: Phthalimidomethyl derivatives 1, encompassing a wide range of leaving group abilities, are rapidly hydrolysed to the corresponding phthalamic acid via rate-determining attack at the phthalimide carbonyl group.
authors.affiliation: Chemistry Department, Open University, Milton Keynes, U.K.
authors.forename: J
authors.initials: J
authors.lastname: Iley
authors.forename: T
authors.initials: T
authors.lastname: Calheiros
authors.forename: R
authors.initials: R
authors.lastname: Moreira
mesh_terms: D006868:Hydrolysis; D007202:Indicators and Reagents; D007700:Kinetics; D015394:Molecular Structure; D010797:Phthalimides / Q000138:chemical synthesis* / Q000737:chemistry; D011355:Prodrugs / Q000138:chemical synthesis* / Q000737:chemistry; D012439:Saccharin / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D007202:Indicators and Reagents; D010797:Phthalimides; D011355:Prodrugs; D012439:Saccharin