title: [Markedly decreased uptake with 123I-MIBG myocardial scintigraphy in a case with vasospastic angina].
abstract: A 68-year-old female whose myocardial sympathetic function was severely damaged with multi-vessel vasospastic angina is presented. She had no signs of autonomic dysfunction or diabetes mellitus. Myocardial imaging with 123I-MIBG showed extremely diminished uptake, but 201TlCl and 123I-BMIPP SPECT images were almost normal. Coronary arteriography revealed no significant atherosclerotic stenosis, multivessel spasm was observed by provocation test using acetylcholine. The extremely diminished uptake of 123I-MIBG was slightly increased in response to medication and the subsequent improvement of the patient's condition. Markedly decreased uptake with 123I-MIBG myocardial scintigraphy was considered to be due to multi-vessel spastic angina. We believe that this method of imaging study is useful for evaluating the healing stage of myocardial sympathetic dysfunction.
authors.affiliation: Division of Cardiology and Radiology, Ehime Prefectural Minamiuwa Hospital.
authors.forename: K
authors.initials: K
authors.lastname: Watanabe
authors.forename: T
authors.initials: T
authors.lastname: Tsuruoka
authors.forename: M
authors.initials: M
authors.lastname: Sekiya
authors.forename: J
authors.initials: J
authors.lastname: Funada
authors.forename: H
authors.initials: H
authors.lastname: Nakagawa
mesh_terms: D019797:3-Iodobenzylguanidine; D000368:Aged; D000789:Angina, Unstable / Q000000981:diagnostic imaging* / Q000188:drug therapy; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D003329:Coronary Vasospasm / Q000000981:diagnostic imaging* / Q000188:drug therapy; D004110:Diltiazem / Q000627:therapeutic use; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging* / Q000294:innervation; D006801:Humans; D007457:Iodine Radioisotopes; D007548:Isosorbide Dinitrate / Q000627:therapeutic use; D009206:Myocardium / Q000378:metabolism; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013564:Sympathetic Nervous System / Q000503:physiopathology; D014665:Vasodilator Agents / Q000627:therapeutic use
chemical_list: D002121:Calcium Channel Blockers; D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D014665:Vasodilator Agents; D019797:3-Iodobenzylguanidine; D004110:Diltiazem; D007548:Isosorbide Dinitrate