title: Confined placental mosaicism for trisomy 8 and intra-uterine growth retardation.
abstract: This report describes a case of apparent confined placental mosaicism for trisomy 8 in a pregnancy which produced a male infant with intra-uterine growth retardation. Postnatal cytogenetic and molecular studies were consistent with biparental disomy 8. Postnatally, the infant experienced a period of rapid catch-up growth and exhibited no clinical features of trisomy 8 mosaicism. His development was age appropriate.
authors.affiliation: Division of Medical Genetics, University of Virginia Hospital, Charlottesville, USA.
authors.forename: E
authors.initials: E
authors.lastname: Saks
authors.forename: M C
authors.initials: MC
authors.lastname: Mccoy
authors.forename: J
authors.initials: J
authors.lastname: Damron
authors.forename: T E
authors.initials: TE
authors.lastname: Kelly
mesh_terms: D000328:Adult; D015193:Chorionic Villi Sampling; D002898:Chromosomes, Human, Pair 8; D005260:Female; D005317:Fetal Growth Retardation / Q000235:genetics*; D005865:Gestational Age; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008297:Male; D009030:Mosaicism; D010920:Placenta; D011247:Pregnancy; D014314:Trisomy