Naphthoquinone analogs as inactivators of cdc25 phosphatase.
cdc25A and cdc25B were significantly overexpressed in certain types of cancers, and they represent potential therapeutic targets for anticancer drug. In this study, naphthoquinone analogs as cdc25A phosphatase inactivators were investigated.
Ham
S W
SW
Department of Chemistry, Chung-Ang University, Seoul, Korea.
Park
J
J
Lee
S J
SJ
Kim
W
W
Kang
K
K
Choi
K H
KH
D002453:Cell Cycle; D018797:Cell Cycle Proteins / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D005434:Flow Cytometry; D019204:GTP-Binding Proteins / Q000037:antagonists & inhibitors*; D006801:Humans; D008956:Models, Chemical; D009285:Naphthoquinones / Q000737:chemistry* / Q000494:pharmacology; D010749:Phosphoprotein Phosphatases / Q000037:antagonists & inhibitors*; D014407:Tumor Cells, Cultured; D014812:Vitamin K / Q000737:chemistry; D020687:cdc25 Phosphatases
D018797:Cell Cycle Proteins; D004791:Enzyme Inhibitors; D009285:Naphthoquinones; D014812:Vitamin K; D010749:Phosphoprotein Phosphatases; D020687:cdc25 Phosphatases; D019204:GTP-Binding Proteins