title: Three-dimensional modeling of static vestibulo-ocular brain stem syndromes.
abstract: Static vestibulo-ocular brain stem syndromes characterized by skew deviation, a vertical disconjugacy of the eyes, and ocular torsion are the result of a vestibular tone imbalance in the frontal (roll) plane. Similar physiological changes in static eye position, ocular counter-roll and conjugated deviations of vertical eye position, are caused by the influence of gravity mediated by the utricles. These observations prompted our approach with the model described here: based on the known deviations of static eye position, we devised a three-dimensional mathematical model of otolith-ocular function including detailed brain stem anatomy. This model is able to explain and predict the differential effects of unilateral and bilateral peripheral or central vestibular lesions on static eye position in roll, pitch, and yaw planes.
authors.affiliation: Department of Neurology, Klinikum Grosshadern, Ludwig-Maximilians-University, München, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Glasauer
authors.forename: M
authors.initials: M
authors.lastname: Dieterich
authors.forename: T
authors.initials: T
authors.lastname: Brandt
mesh_terms: D000818:Animals; D001933:Brain Stem / Q000473:pathology / Q000503:physiopathology*; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008433:Mathematics; D008959:Models, Neurological; D009801:Oculomotor Muscles / Q000503:physiopathology; D012027:Reflex, Vestibulo-Ocular / Q000502:physiology*; D013577:Syndrome; D014102:Torsion Abnormality