title: Myelodysplastic syndrome with myelofibrosis and basophilia: detection of trisomy 8 in basophils by fluorescence in-situ hybridization.
abstract: We report a case of myelodysplastic syndrome (MDS) with myelofibrosis and pulmonary tuberculosis who had marked basophilia in the peripheral blood. A clonal karyotypic abnormality characterized by trisomy 8 was demonstrated by cytogenetic analysis. By correlation of cell morphology with results of fluorescence in situ hybridization using a chromosome 8 probe, we demonstrated that the basophils were not reactive but belonged to the neoplastic MDS clone.
authors.affiliation: Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong. eskma@hkucc.hku.hk
authors.forename: S K
authors.initials: SK
authors.lastname: Ma
authors.forename: J C
authors.initials: JC
authors.lastname: Chan
authors.forename: T S
authors.initials: TS
authors.lastname: Wan
authors.forename: A Y
authors.initials: AY
authors.lastname: Chan
authors.forename: L C
authors.initials: LC
authors.lastname: Chan
mesh_terms: D000328:Adult; D000753:Anemia, Refractory / Q000150:complications / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology*; D001491:Basophils / Q000473:pathology; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D055728:Primary Myelofibrosis / Q000150:complications / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D014314:Trisomy; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000235:genetics* / Q000503:physiopathology*