Preliminary evaluation of Leucaena leucocephala seed gum as a tablet binder.
The seed galactomannan of Leucaena leucocephala Lam. de Wit var.K-8 (family Leguminosae), a natural polysaccharide, with properties comparable to guar gum, was evaluated as a pharmaceutical binder. Characterization was done using studies of compressibility, micromeritic, and mechanical properties of granules prepared by wet granulation and subsequent studies on compacts, both containing 5% w/w of binder. The seed gum was subsequently used as a binder with a badly compressible material, paracetamol, and studied likewise. The seed gum compared will with standard pharmaceutical binders (starch and polyvinyl pyrrolidone [PVP] K30), at least for properties studied herein.
Deodhar
U P
UP
Department of Pharmacognosy, Poona College of Pharmacy, Pune, India.
Paradkar
A R
AR
Purohit
A P
AP
D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D005069:Evaluation Studies as Topic; D005079:Excipients; D007887:Fabaceae; D005690:Galactose / Q000031:analogs & derivatives; D006801:Humans; D008351:Mannans / Q000737:chemistry / Q000302:isolation & purification; D010946:Plants, Medicinal; D011205:Povidone; D013213:Starch; D013607:Tablets
D005079:Excipients; D008351:Mannans; D013607:Tablets; C012990:galactomannan; D013213:Starch; D011205:Povidone; D005690:Galactose