title: NMR and topochemical studies of peptidomimetic HIV-I protease inhibitors containing a cis-epoxide amide isostere.
abstract: NMR and topochemical studies of irreversible HIV-1 protease inhibitors containing a cis-epoxide as amide isostere have been carried out to identify conformational preference of the inhibitors in solution. The inhibitors prefer to adopt extended conformations similar to the beta-strand in solution.
authors.affiliation: Biotech Research Institute, LG Chemical Ltd./Research Park, Taejon, Korea.
authors.forename: S
authors.initials: S
authors.lastname: Ro
authors.forename: S G
authors.initials: SG
authors.lastname: Baek
authors.forename: B
authors.initials: B
authors.lastname: Lee
authors.forename: C
authors.initials: C
authors.lastname: Park
authors.forename: N
authors.initials: N
authors.lastname: Choy
authors.forename: C S
authors.initials: CS
authors.lastname: Lee
authors.forename: Y C
authors.initials: YC
authors.lastname: Son
authors.forename: H
authors.initials: H
authors.lastname: Choi
authors.forename: J S
authors.initials: JS
authors.lastname: Koh
authors.forename: H
authors.initials: H
authors.lastname: Yoon
authors.forename: S C
authors.initials: SC
authors.lastname: Kim
authors.forename: J H
authors.initials: JH
authors.lastname: Ok
mesh_terms: D018360:Crystallography, X-Ray; D004852:Epoxy Compounds / Q000737:chemistry; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis / Q000737:chemistry*; D015497:HIV-1; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D008958:Models, Molecular; D018716:Molecular Mimicry; D011487:Protein Conformation
chemical_list: D004852:Epoxy Compounds; D017320:HIV Protease Inhibitors