Natural killer and T cells of innate and adaptive immunity: lymphoid compartments with different requirements for common gamma chain-dependent cytokines.
A group of cytokines, including interleukin-2, -4, -7, -9 and -15, are related through the usage of a shared receptor subunit, the common cytokine receptor gamma chain, gamma c. gamma c-dependent cytokines critically affect the development and maintenance of the lymphoid system. This review will highlight our current knowledge on the gamma c-dependent cytokine network and on the non-redundant roles that these cytokines play in the development and homeostasis of T and natural killer cells involved in innate and adaptive immunity.
Di Santo
J P
JP
INSERM U429, Hôpital Necker-Enfants Malades, Paris, France. disanto@necker.fr
Colucci
F
F
Guy-Grand
D
D
D000818:Animals; D002454:Cell Differentiation; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007142:Immunoglobulin gamma-Chains / Q000276:immunology*; D007422:Intestines / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology; D016693:Receptors, Antigen, T-Cell, alpha-beta; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology
D016207:Cytokines; D007142:Immunoglobulin gamma-Chains; D016693:Receptors, Antigen, T-Cell, alpha-beta