[The effect of sodium thiosulfate on nonspecific body resistance and on the immune reactions in acute acrylonitrile poisoning].
Experiments on noninbred Wistar mice and rats showed that acute acrylonitrile (0.5 LD50) intoxication leads to decrease of nonspecific resistance of the organism and humoral and cellular immunity responses. The antidote sodium thiosulfate increases suppression of the responses under study.
Zabrodskiĭ
P F
PF
Department of Toxicology, Saratov State Medical University, Russia.
Romashchenko
S A
SA
D000181:Acrylonitrile / Q000506:poisoning*; D000208:Acute Disease; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000931:Antidotes / Q000627:therapeutic use*; D003864:Depression, Chemical; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D007111:Immunity, Cellular / Q000187:drug effects; D007113:Immunity, Innate / Q000187:drug effects; D007153:Immunologic Deficiency Syndromes / Q000139:chemically induced / Q000188:drug therapy / Q000276:immunology; D051379:Mice; D011041:Poisoning / Q000150:complications / Q000188:drug therapy / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar; D013885:Thiosulfates / Q000627:therapeutic use*
D000931:Antidotes; D013885:Thiosulfates; C017717:sodium thiosulfate; D000181:Acrylonitrile
Vliianie tiosul'fata natriia na nespetsificheskuiu rezistentnost' organizma i immunnye reaktsii pri ostrom otravlenii akrilonitrilom.