title: Diimidazo[1,2-c:4',5'-e]pyrimidines: adenosine agonist activity demonstrated by microphysiometry.
abstract: Silicon-based microphysiometry, measuring extracellular acidification rate of cells in culture, demonstrated that a series of diimidazo[1,2-c:4',5'-e]pyrimidines were agonists at the human adenosine A1 receptor. 5-amino-7,8-dihydro-3-ribofuranose-8-(R)-(phenyl)-3H-diimidazo [1,2-c:4',5'-e]pyrimidine (2a) had an EC50 of 100 microM and reached 90% of the Emax produced by R-PIA.
authors.affiliation: Queensland Pharmaceutical Research Institute, Griffith University, Brisbane, Australia.
authors.forename: D
authors.initials: D
authors.lastname: Camp
authors.forename: J M
authors.initials: JM
authors.lastname: Green
authors.forename: S M
authors.initials: SM
authors.lastname: Kaiser
authors.forename: R W
authors.initials: RW
authors.lastname: Moni
authors.forename: A
authors.initials: A
authors.lastname: Townsend-Nicholson
authors.forename: P R
authors.initials: PR
authors.lastname: Schofield
authors.forename: R J
authors.initials: RJ
authors.lastname: Quinn
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D002478:Cells, Cultured; D003342:Corpus Striatum / Q000378:metabolism; D006801:Humans; D008832:Microchemistry / Q000379:methods; D008956:Models, Chemical; D010660:Phenylisopropyladenosine / Q000031:analogs & derivatives* / Q000378:metabolism; D058906:Purinergic P1 Receptor Agonists; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D018047:Receptors, Purinergic P1 / Q000378:metabolism*; D012825:Silicon
chemical_list: D058906:Purinergic P1 Receptor Agonists; D011743:Pyrimidines; D018047:Receptors, Purinergic P1; D010660:Phenylisopropyladenosine; D012825:Silicon