Selective photocleavage of single-stranded nucleic acids by cyclobisintercaland molecules.
Irradiation of mixtures of a single-stranded circular plasmid and of a double-stranded supercoiled DNA in presence of the cyclobisintercaland compounds 2 or 3 shows that these reagents effect the selective photocleavage of the single-stranded entity. Furthermore, 2 also cleaves tRNAasp preferentially at single-stranded domains.
Blacker
A J
AJ
Laboratoire de Chimie Supramoléculaire, ISIS, Université Louis Pasteur, Strasbourg, France.
Teulade-Fichou
M P
MP
Vigneron
J P
JP
Fauquet
M
M
Lehn
J M
JM
D004277:DNA, Single-Stranded / Q000378:metabolism* / Q000528:radiation effects; D004278:DNA, Superhelical / Q000378:metabolism; D004587:Electrophoresis, Agar Gel; D008956:Models, Chemical; D008958:Models, Molecular; D009690:Nucleic Acid Conformation / Q000187:drug effects / Q000528:radiation effects; D010777:Photochemistry; D010957:Plasmids / Q000378:metabolism; D012313:RNA / Q000378:metabolism* / Q000528:radiation effects
D004277:DNA, Single-Stranded; D004278:DNA, Superhelical; D012313:RNA