Bone marrow suppression and klebsiella pneumonia septicemia due to ticlopidine and successful treatment with filgrastim; a case report.
In this report we describe an elderly lady, who after 27 days of ticlopidine treatment developed severe pancytopenia and gram (-) septicemia. No clinical response was obtained with an eight days course of empirical broad spectrum antibiotics, after which granulocyte colony stimulating factor (G-CSF, filgrastim) added to her regimen. In a period of seven days her neutrophil count was normal and she had recovered from septicemia. Twelve weeks after discharge she is fine and her blood parameters are all normal.
Korkmaz
M E
ME
Cekin
A H
AH
D001707:Biopsy, Needle; D001853:Bone Marrow / Q000187:drug effects*; D005260:Female; D000069585:Filgrastim; D005500:Follow-Up Studies; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D007710:Klebsiella Infections / Q000139:chemically induced* / Q000188:drug therapy / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000302:isolation & purification; D007958:Leukocyte Count; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced* / Q000188:drug therapy / Q000382:microbiology; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D011994:Recombinant Proteins; D018805:Sepsis / Q000139:chemically induced* / Q000188:drug therapy / Q000382:microbiology; D013988:Ticlopidine / Q000009:adverse effects*
D010975:Platelet Aggregation Inhibitors; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D013988:Ticlopidine; D000069585:Filgrastim