title: A concise synthesis and in vitro cytotoxicity of new labdane diterpenes.
abstract: A new series of labdane-related diterpenes have been synthesized from (-)-sclareol and assayed in vitro cytotoxicity against mouse and human cancer cells. A key intermediate, homodrimane and furanolabdane derivatives show good in vitro cytotoxicity comparable to those of mitomycin C and adriamycin.
authors.affiliation: Department of Chemistry, Yonsei University, Seoul, Korea.
authors.forename: M
authors.initials: M
authors.lastname: Jung
authors.forename: I
authors.initials: I
authors.lastname: Ko
authors.forename: S
authors.initials: S
authors.lastname: Lee
authors.forename: S J
authors.initials: SJ
authors.lastname: Choi
authors.forename: B H
authors.initials: BH
authors.lastname: Youn
authors.forename: S K
authors.initials: SK
authors.lastname: Kim
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004224:Diterpenes / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D051379:Mice; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes