Synthesis and antitumor activity of 4-phenyl-1-arylsulfonyl imidazolidinones.
Novel 1-(1-benzoylindoline-5-sulfonyl)-4-phenyl-4,5-dihydroimidazolon es 3 synthesized show highly potent and broad cytotoxicities. Among them compound 3b (DW2143) exhibits much more potent cytotoxicities than doxorubicin and highly effective antitumor activities against murine (3LL, Colon 26) and human xenograft (NCI-H23, SW620) tumor models.
Jung
S H
SH
College of Pharmacy, Chungnam National University, Taejon, Korea.
Lee
H S
HS
Song
J S
JS
Kim
H M
HM
Han
S B
SB
Lee
C W
CW
Lee
M
M
Choi
D R
DR
Lee
J A
JA
Chung
Y H
YH
Yoon
S J
SJ
Moon
E Y
EY
Hwang
H S
HS
Seong
S K
SK
Lee
D K
DK
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D051379:Mice; D013450:Sulfones / Q000138:chemical synthesis / Q000494:pharmacology; D014183:Transplantation, Heterologous; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D007093:Imidazoles; D013450:Sulfones; C116727:DW 2143