Aryl phosphate derivatives of 3'-deoxythymidine are not potent anti-human immunodeficiency virus agents.
Aryl phosphate derivatives of 3'-deoxythymidine (3dT), albeit more active than 3dT in thymidine kinase (TK)-deficient cells, are not potent anti-human immunodeficiency virus (HIV) agents and are capable of inhibiting HIV replication only at micromolar concentrations.
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Drug Discovery Program, Hughes Institute, St Paul, Minnesota 55113, USA.
Venkatachalam
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TK
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Uckun
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FM
D019380:Anti-HIV Agents / Q000737:chemistry* / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010710:Phosphates / Q000737:chemistry* / Q000494:pharmacology; D013936:Thymidine / Q000031:analogs & derivatives*; D014779:Virus Replication / Q000187:drug effects
D019380:Anti-HIV Agents; D000998:Antiviral Agents; D010710:Phosphates; D013936:Thymidine