title: Synthesis of anti-rheumatic agent epoxyquinomicin B.
abstract: Anti-rheumatic agent (+/-)-epoxyquinomicin B was synthesized for a 22% overall yield in eight steps from commercially available 3-hydroxy-4-nitrobenzaldehyde via the intermediate quinone 6 prepared by selective phenol oxidation of 5 by use of Fremy's salt as the key step.
authors.affiliation: Institute of Microbial Chemistry, Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Matsumoto
authors.forename: H
authors.initials: H
authors.lastname: Iinuma
authors.forename: T
authors.initials: T
authors.lastname: Sawa
authors.forename: T
authors.initials: T
authors.lastname: Takeuchi
mesh_terms: D018501:Antirheumatic Agents / Q000138:chemical synthesis*; D001549:Benzamides / Q000138:chemical synthesis*; D011809:Quinones / Q000138:chemical synthesis*
chemical_list: D018501:Antirheumatic Agents; D001549:Benzamides; D011809:Quinones; C099342:epoxyquinomicin B