title: Synthesis and properties of prodrugs activated in hypoxia to give bleomycin analogues.
abstract: Prodrugs bioreductively activated to bleomycin analogues are reported. The production of hydroxyl radicals in the presence of FE(II) and dioxygen by both the prodrugs and the activated products are determined and their in vitro cytotoxicity measured.
authors.affiliation: Chemistry Section, Institute for Physical and Environmental Sciences, Brunel University, Uxbridge, Middlesex, UK.
authors.forename: J A
authors.initials: JA
authors.lastname: Highfield
authors.forename: L K
authors.initials: LK
authors.lastname: Mehta
authors.forename: J
authors.initials: J
authors.lastname: Parrick
authors.forename: L P
authors.initials: LP
authors.lastname: Candeias
authors.forename: P
authors.initials: P
authors.lastname: Wardman
mesh_terms: D000818:Animals; D001761:Bleomycin / Q000031:analogs & derivatives* / Q000378:metabolism; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D017665:Hydroxyl Radical; D000860:Hypoxia / Q000378:metabolism*; D007501:Iron / Q000378:metabolism; D008956:Models, Chemical; D011355:Prodrugs / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism
chemical_list: D011355:Prodrugs; D001761:Bleomycin; D017665:Hydroxyl Radical; D007501:Iron