title: The relationship between infection and disease in Wuchereria bancrofti infection in Ghana.
abstract: The relationship between infection and clinical disease in Wuchereria bancrofti infection was investigated in a community-based study in different endemic areas in Ghana. At the individual level, there was no association between acute adenolymphangitis and infection (microfilaraemia) status. There was a negative association between infection status and lymphoedema/elephantiasis, but a positive association with hydrocele; however, the intensity of infection was negatively associated with both elephantiasis and hydrocele. The community prevalence of infection was strongly associated with the prevalence of clinical filariasis (especially hydrocele). There was a strong positive association between the prevalence of infection in males and the odds of a case of hydrocele being microfilaraemic, suggesting that there is no acquired immunity to reinfection in cases of hydrocele. The pathophysiologies of elephantiasis and hydrocele may therefore differ from one another, and require further investigation.
authors.affiliation: Health Research Unit, Ministry of Health, Accra, Ghana. gpcd@ighmail.com
authors.forename: J O
authors.initials: JO
authors.lastname: Gyapong
mesh_terms: D017677:Age Distribution; D000818:Animals; D005368:Filariasis / Q000453:epidemiology*; D005869:Ghana / Q000453:epidemiology; D006801:Humans; D008205:Lymphangitis / Q000453:epidemiology*; D008297:Male; D012423:Rural Health; D006848:Testicular Hydrocele / Q000453:epidemiology*; D014958:Wuchereria bancrofti / Q000472:pathogenicity*