High signal in the adenohypophysis on T1-weighted images presumably due to manganese deposits in patients on long-term parenteral nutrition.
Hypermanganesaemia is reported in patients on long-term parenteral nutrition. Deposition of manganese, giving high signal on T1-weighted images, may involve the basal ganglia. MRI in nine patients (mean age 51 years, range 31-75 years) on long-term parenteral nutrition (mean duration 30 months, range 6-126 months), demonstrated high signal in the anterior pituitary gland on T1-weighted sagittal and coronal images. The gland appeared normal on T2-weighted images. Signal intensity in the basal ganglia on T1-weighted images was increased in all patients. Endocrine assessment showed no significant abnormality. Neurological examination showed a mild parkinsonian movement disorder in one patient. Hypermanganaesemia was present in all nine (1.3-2.8 micromol/l, mean 1.87 micromol/l). The high signal in the anterior pituitary gland was probably related to deposition of paramagnetic substances, especially manganese.
Dietemann
J L
JL
Department of Radiology 2, University Hospital of Strasbourg, Hôpital de Hautepierre, France.
Reimund
J M
JM
Diniz
R L
RL
Reis
M
M
Baumann
R
R
Neugroschl
C
C
Von Söhsten
S
S
Warter
J M
JM
D000328:Adult; D000367:Age Factors; D000368:Aged; D001479:Basal Ganglia / Q000033:anatomy & histology / Q000737:chemistry; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008345:Manganese / Q000032:analysis* / Q000097:blood; D008875:Middle Aged; D010288:Parenteral Nutrition; D010903:Pituitary Gland, Anterior / Q000033:anatomy & histology* / Q000737:chemistry; D012737:Sex Factors
D008345:Manganese