title: Anti-inflammatory/antiarthritic ketonic bisphosphonic acid esters.
abstract: Bisphosphonate ester 2 is an inhibitor of inflammation, but is devoid of antiarthritic effects. SAR studies on a series of related bisphosphonate esters resulted in compounds 6e, 6i, 6j, and 6m, which exhibited excellent inhibition of an arthritis model, in addition to potent anti-inflammatory effects.
authors.affiliation: Pharmacia & Upjohn, Kalamazoo, MI 49001, USA.
authors.forename: S T
authors.initials: ST
authors.lastname: Schlachter
authors.forename: L A
authors.initials: LA
authors.lastname: Galinet
authors.forename: S K
authors.initials: SK
authors.lastname: Shields
authors.forename: D G
authors.initials: DG
authors.lastname: Aspar
authors.forename: C J
authors.initials: CJ
authors.lastname: Dunn
authors.forename: N D
authors.initials: ND
authors.lastname: Staite
authors.forename: R A
authors.initials: RA
authors.lastname: Nugent
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D001169:Arthritis, Experimental / Q000188:drug therapy*; D004164:Diphosphonates / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D015195:Drug Design; D006099:Granuloma / Q000188:drug therapy / Q000276:immunology; D006968:Hypersensitivity, Delayed; D007202:Indicators and Reagents; D007249:Inflammation / Q000188:drug therapy*; D051379:Mice; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004164:Diphosphonates; D007202:Indicators and Reagents