[Acquired cytomegalovirus infections in immunocompetent adults: 116 cases].
OBJECTIVE
To analyse retrospectively the clinical, biological and epidemiological features of cytomegalovirus (CMV) infection in the immunocompetent host.


METHODS
A retrospective study was conducted in 116 cases of CMV infection (74 inpatients, 42 out-patients) collected from 1981 to 1997 in a university hospital. Diagnostic was established on serological criteria in all cases.


RESULTS
Fever was observed in all cases but one (mean duration: 21 days). The most frequent symptoms were headache (51%) and myalgia (46%). Splenomegaly was the most frequent sign (36%). Pulmonary interstitial opacities on chest x-ray were found in 8.5% of patients. Pulmonary (1 case) and neurological (2 cases) complications occurred. Concomitant HIV primary infection was observed in 2 patients. Mononucleosis and ALAT and LDH elevations were observed in 95%, 85% and 95% of cases respectively. Viremia was positive in 79% (30/38). pp65 antigenemia was useful to establish the diagnosis in 9 patients. Antibiotics were prescribed in 46% before diagnosis was established.


CONCLUSIONS
CMV infection in the immunocompetent host is a frequent and rarely complicated disease. pp65 antigenemia should be evaluated more in this setting. Most hospitalizations due to this affection could be avoided.
Faucher
J F
JF
Service des Maladies infectieuses et tropicales, Hôpital Gui de Chauliac, Montpellier.
Abraham
B
B
Segondy
M
M
Jonquet
O
O
Reynes
J
J
Janbon
F
F
D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000175:diagnosis / Q000821:virology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007297:Inpatients; D008297:Male; D008875:Middle Aged; D010045:Outpatients; D012189:Retrospective Studies; D012698:Serologic Tests
D000914:Antibodies, Viral; D007136:Immunoglobulins
Cytomégalovirose acquise de l'adulte immunocompétent. 116 observations.