title: Isoindolinone enantiomers having affinity for the dopamine D4 receptor.
abstract: PD 108635 (1) was identified as a potent dopamine D4 ligand and we wanted to replace the benzylic alcohol with a metabolically more stable moiety. Investigations led to the discovery of a series of isoindolinones having D4 affinity.
authors.affiliation: Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Co., Ann Arbor, MI 48105, USA.
authors.forename: T R
authors.initials: TR
authors.lastname: Belliotti
authors.forename: W A
authors.initials: WA
authors.lastname: Brink
authors.forename: S R
authors.initials: SR
authors.lastname: Kesten
authors.forename: J R
authors.initials: JR
authors.lastname: Rubin
authors.forename: D J
authors.initials: DJ
authors.lastname: Wustrow
authors.forename: K T
authors.initials: KT
authors.lastname: Zoski
authors.forename: S Z
authors.initials: SZ
authors.lastname: Whetzel
authors.forename: A E
authors.initials: AE
authors.lastname: Corbin
authors.forename: T A
authors.initials: TA
authors.lastname: Pugsley
authors.forename: T G
authors.initials: TG
authors.lastname: Heffner
authors.forename: L D
authors.initials: LD
authors.lastname: Wise
mesh_terms: D000818:Animals; D007211:Indoles / Q000737:chemistry* / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017448:Receptors, Dopamine D2 / Q000187:drug effects*; D050638:Receptors, Dopamine D4; D011985:Receptors, Serotonin / Q000378:metabolism; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014961:X-Ray Diffraction
chemical_list: C493601:Drd4 protein, rat; D007211:Indoles; D017448:Receptors, Dopamine D2; D011985:Receptors, Serotonin; D050638:Receptors, Dopamine D4