title: Color Doppler ultrasound velocimetry of internal carotid arteries in normal pregnancies.
abstract: BACKGROUND
  There are few reports on maternal cerebral circulation during pregnancy. Using the hypothesis that cerebral blood flow resistance decreases progressively with advancing gestational age (GA) as a consequence of estrogenic effects on the vascular system during pregnancy, we calculated the pulsatility index (PI) and the mean velocity (MV) of the maternal right internal carotid artery (ICA) in order to build fitted reference centiles.
  
  
  METHODS
  A total of 315 pregnant women with a single fetus were studied at 20-42 weeks' gestation. The patients had uncomplicated singleton pregnancies and were without any known fetal or maternal risk factors. Duplex color ultrasound with a pulsed Doppler scanner (7.5 MHz) was used to determine the PI and MV of the maternal ICA.
  
  
  RESULTS
  Among the 315 healthy pregnant women, the PI of maternal ICA decreased progressively with advancing GA, PI50th = Exp (0.3124-0.0084 x GA), (p = 0.0003), during the second half of pregnancy. The predicted 50th percentile PI values of the ICA decreased from 1.117 (5th% = 0.755, 95th% = 1.654) at 24 weeks' gestation to 0.917 (5th% = 0.659, 95th% = 1.448) at 40 weeks' gestation. The MV of the maternal ICA also decreased progressively with advancing GA, MV50th = Exp (3.855-0.0093 x GA), (p = 0.0005), during the second half of pregnancy. The predicted 50th percentile MV values in the ICA decreased from 37.811 cm/sec (5th% = 24.177 cm/sec, 95th% = 59.138 cm/sec) at 24 weeks' gestation to 32.591 cm/sec (5th% = 20.818 cm/sec, 95th% = 51.021 cm/sec) at 40 weeks' gestation.
  
  
  CONCLUSIONS
  Both the PI and MV of the maternal ICA decreased with GA during the second half of normal pregnancy as a result of intracerebral vessel dilatation.
authors.affiliation: Department of Obstetrics and Gynecology, Veterans General Hospital-Taipei, Taiwan, ROC.
authors.forename: J H
authors.initials: JH
authors.lastname: Hung
authors.forename: H T
authors.initials: HT
authors.lastname: Ng
authors.forename: Y P
authors.initials: YP
authors.lastname: Pang
authors.forename: M J
authors.initials: MJ
authors.lastname: Yang
authors.forename: L P
authors.initials: LP
authors.lastname: Shu
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity; D002343:Carotid Artery, Internal / Q000502:physiology*; D005260:Female; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy / Q000502:physiology*; D018615:Ultrasonography, Doppler, Color