title: Hypothalamic hamartoma: report of a case with unusual histologic features.
abstract: A rare case of hypothalamic hamartoma with unusual radiologic and histopathological features is described, possibly the first of its type in English literature. A 1.5-year-old female child presented with precocious puberty. MR scan of the brain revealed a pedunculated hypothalamic mass, most of which was isointense with normal brain on T1- and T2-weighted images. However, a sizeable component of the lesion was hyperintense on T1-weighted images, suggestive of adipose tissue. Microscopically, the lesion was a hamartoma composed of an admixture of neuroectodermal elements, namely glial cells, neurons, and nerve bundles along with mesenchymal elements in the form of fibroadipose tissue.
authors.affiliation: Department of Pathology, All India Institute of Medical Sciences, New Delhi.
authors.forename: M C
authors.initials: MC
authors.lastname: Sharma
authors.forename: S
authors.initials: S
authors.lastname: Gaikwad
authors.forename: A K
authors.initials: AK
authors.lastname: Mahapatra
authors.forename: P S
authors.initials: PS
authors.lastname: Menon
authors.forename: C
authors.initials: C
authors.lastname: Sarkar
mesh_terms: D001927:Brain Diseases / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006222:Hamartoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D007124:Immunoenzyme Techniques; D007223:Infant; D008279:Magnetic Resonance Imaging; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D011629:Puberty, Precocious / Q000209:etiology; D009418:S100 Proteins / Q000378:metabolism; D016708:Synaptophysin / Q000378:metabolism
chemical_list: D005904:Glial Fibrillary Acidic Protein; D009418:S100 Proteins; D016708:Synaptophysin; D010751:Phosphopyruvate Hydratase