Biologically selective potassium channel openers having 1,1-diethylpropyl group.
To find out selective potassium channel openers (PCOs), we synthesized several 3,5-disubstituted phenylcyanoguanidine derivatives and investigated their structure-activity relationships (SAR). As a result, we discovered selective PCOs having 1,1-diethylpropyl group toward antihypertensive activity.
Yoshiizumi
K
K
Pharmaceutical Research Laboratories, Kanebo Ltd., Osaka, Japan.
Seko
N
N
Nishimura
N
N
Ikeda
S
S
Yoshino
K
K
Kondo
H
H
Tanizawa
K
K
D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D019806:Cromakalim / Q000494:pharmacology; D004285:Dogs; D007422:Intestines / Q000187:drug effects; D020110:Pinacidil / Q000494:pharmacology; D015221:Potassium Channels / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014132:Trachea / Q000187:drug effects / Q000502:physiology; D001743:Urinary Bladder / Q000187:drug effects / Q000502:physiology
D000959:Antihypertensive Agents; D015221:Potassium Channels; D019806:Cromakalim; D020110:Pinacidil