title: Cytotoxic constituents of Saussurea lappa.
abstract: The crude extract of Saussurea lappa displayed significant lethality to brine shrimp larvae. Investigation of the causative components by bioactivity-directed fractionation resulted in the isolation of three C17-polyene alcohols. Based on various nmr spectral data, these compounds were identified as shikokiols which had been previously isolated from Cirsium nipponicum and/or Centaurea aegyptica. These C17-polyene alcohols exhibited moderate cytotoxicities against the human tumor cell lines, A549, SK-OV-3, SK-MEL-2, XF498, and HCT15.
authors.affiliation: College of Pharmacy, Pusan National University, Korea.
authors.forename: J H
authors.initials: JH
authors.lastname: Jung
authors.forename: Y
authors.initials: Y
authors.lastname: Kim
authors.forename: C O
authors.initials: CO
authors.lastname: Lee
authors.forename: S S
authors.initials: SS
authors.lastname: Kang
authors.forename: J H
authors.initials: JH
authors.lastname: Park
authors.forename: K S
authors.initials: KS
authors.lastname: Im
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001156:Artemia; D004354:Drug Screening Assays, Antitumor; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic