Synthesis of a series of sulfinic acid analogs of GABA and evaluation of their GABAB receptor affinities.
A series of gamma-aminobutyric acid (GABA) 1 analogs was prepared in which the carboxylic acid group of GABA was replaced with a sulfinic acid group and their affinity for the GABAB receptor investigated.
Carruthers
N I
NI
Department of Chemical Research, Schering-Plough Research Institute, Kenilworth, NJ 07033, USA.
Spitler
J M
JM
Wong
S C
SC
Blythin
D J
DJ
Chen
X
X
Shue
H J
HJ
She
H S
HS
Lee
J F
JF
Rizzo
C
C
Ting
P C
PC
West
R E
RE
D018080:Receptors, GABA-B / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013441:Sulfinic Acids / Q000138:chemical synthesis* / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000138:chemical synthesis* / Q000378:metabolism
D018080:Receptors, GABA-B; D013441:Sulfinic Acids; D005680:gamma-Aminobutyric Acid