Design and synthesis of bio-isosteres of thymidine triphosphate.
This paper describes the design and synthesis of potential isosteres of triphosphates which should show enhanced metabolic stability and lipophilicity compared to triphosphates. The triphosphate isosteres were then linked to nucleosides and evaluated for their inhibitory activity against HIV infection.
Goldring
A O
AO
Welsh School of Pharmacy, University of Wales Cardiff, U.K.
Balzarini
J
J
Gilbert
I H
IH
D003198:Computer Simulation; D015195:Drug Design; D007202:Indicators and Reagents; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D013237:Stereoisomerism; D013942:Thymine Nucleotides / Q000138:chemical synthesis* / Q000737:chemistry*
D007202:Indicators and Reagents; D013942:Thymine Nucleotides; C024157:thymidine 5'-triphosphate