title: Synthesis and pharmacological activities of 13-dehydro derivatives of primary prostaglandins.
abstract: 13-Dehydro derivatives of prostaglandin E1, E2, E3, F1 alpha and F2 alpha were synthesized. Compared with natural prostaglandins, 13-dehydro analogues were found to exhibit more potent inhibitory activity against human platelet aggregation and relaxation of guinea-pig isolated trachea, while they showed less potent activity of contraction of guinea-pig isolated ileum.
authors.affiliation: Research Center, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tanami
authors.forename: K
authors.initials: K
authors.lastname: Kameo
authors.forename: N
authors.initials: N
authors.lastname: Ono
authors.forename: T
authors.initials: T
authors.lastname: Nakagawa
authors.forename: S
authors.initials: S
authors.lastname: Annou
authors.forename: M
authors.initials: M
authors.lastname: Tsuboi
authors.forename: K
authors.initials: K
authors.lastname: Tani
authors.forename: S
authors.initials: S
authors.lastname: Okamoto
authors.forename: F
authors.initials: F
authors.lastname: Sato
mesh_terms: D000818:Animals; D006168:Guinea Pigs; D006801:Humans; D007082:Ileum / Q000187:drug effects / Q000502:physiology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009119:Muscle Contraction / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D011453:Prostaglandins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D010975:Platelet Aggregation Inhibitors; D011453:Prostaglandins