A mixed resin bed for the quenching and purification of tetrabutylammonium fluoride mediated desilylating reactions.
A polymer-bound calcium sulfonate resin is prepared and used to sequester tetrabutylammonium fluoride. The simultaneous use of the calcium sulfonate resin with a sulfonic acid resin is used for the quenching and purification of desilylating reactions involving tetrabutylammonium fluoride as the reagent. Employment of this resin workup technique eliminates the need for a liquid-phase extractive protocol allowing the procedure to be easily automated.
Parlow
J J
JJ
Parallel Medicinal and Combinatorial Chemistry, Searle Discovery Research-U2D Monsanto Company, St. Louis, MO 63167, USA.
Vazquez
M L
ML
Flynn
D L
DL
D001331:Automation; D002625:Chemistry, Organic / Q000379:methods*; D003902:Detergents; D005459:Fluorides; D007202:Indicators and Reagents; D007700:Kinetics; D008968:Molecular Conformation; D015394:Molecular Structure; D000644:Quaternary Ammonium Compounds; D012117:Resins, Synthetic; D012821:Silanes; D013329:Structure-Activity Relationship
D003902:Detergents; D007202:Indicators and Reagents; D000644:Quaternary Ammonium Compounds; D012117:Resins, Synthetic; D012821:Silanes; C009405:tetrabutylammonium; D005459:Fluorides