Alkylation of succinates: synthesis of Ro 32-3555.
A short synthesis, based on a succinate acylation-alkylation-decarboxylation approach, of the clinical compound Ro 32-3555 is reported. The nature of the selectivity in the mono-alkylation of succinates was examined under varying enolization conditions and in the presence of chaotropic additives.
McClure
K F
KF
Pfizer Central Research, Groton, CT 06340, USA.
Axt
M Z
MZ
D000478:Alkylation; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D061965:Matrix Metalloproteinase Inhibitors; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013386:Succinates / Q000737:chemistry*
D007093:Imidazoles; D061965:Matrix Metalloproteinase Inhibitors; D011480:Protease Inhibitors; C106997:Ro 32-3555; D013386:Succinates