Expression of specific white adipose tissue genes in denervation-induced skeletal muscle fatty degeneration.
Denervation of skeletal muscle results in rapid atrophy with loss of contractile mass and/or progressive degeneration of muscle fibers which are replaced to a greater or lesser degree by connective and fatty tissues. In this study, we show that denervated rabbit muscles are transformed into a white adipose tissue, depending on their fiber types. This tissue does express LPL, G3PDH and particularly the ob gene, a white adipose tissue-specific marker, and does not express the brown adipose tissue molecular marker UCP1 mRNA.
Dulor
J P
JP
UFR Productions animales, ENSA M, Laboratoire de Différenciation cellulaire et Croissance, INRA, Montpellier, France. dulor@ensam.inra.fr
Cambon
B
B
Vigneron
P
P
Reyne
Y
Y
Nouguès
J
J
Casteilla
L
L
Bacou
F
F
D000273:Adipose Tissue / Q000201:enzymology / Q000294:innervation* / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D015415:Biomarkers; D005993:Glycerolphosphate Dehydrogenase / Q000378:metabolism; D020738:Leptin; D008071:Lipoprotein Lipase / Q000378:metabolism; D009121:Muscle Denervation; D018485:Muscle Fibers, Skeletal / Q000502:physiology; D018482:Muscle, Skeletal / Q000294:innervation* / Q000378:metabolism / Q000473:pathology; D018008:Myogenin / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D011817:Rabbits
D015415:Biomarkers; D020738:Leptin; D018008:Myogenin; D011506:Proteins; D012333:RNA, Messenger; D005993:Glycerolphosphate Dehydrogenase; D008071:Lipoprotein Lipase