title: Elevated serum cytokines are associated with cytomegalovirus infection and disease in bone marrow transplant recipients.
abstract: To assess the relationship between serum cytokines and cytomegalovirus (CMV) reactivation, 75 allogeneic bone marrow transplant patients underwent weekly measurements of interleukin (IL)-6, IL-8, and tumor necrosis factor (TNF)-alpha, CMV blood cultures, and antigenemia tests. Of the patients, 44 (58.7%) developed CMV infection, and 19 (25.3%) developed clinical CMV disease. The mean maximum levels of all three cytokines were significantly increased in patients with CMV infection compared with levels in those without. Maximum levels of IL-6 were significantly higher in patients with active CMV disease than in those who did not develop CMV disease (281.2+/-85.5 vs. 95.7+/-15.0 pg/mL; P=.034). Levels of IL-8 and TNF-alpha were also elevated in patients who developed active disease. In a multivariate logistic regression model, IL-6 levels were independently associated with CMV disease (odds ratio=1.70 per 100-pg/mL increase in IL-6; P=.009). Cytokines may play an important role in the pathogenesis of CMV after bone marrow transplantation and may be a useful predictor for CMV.
authors.affiliation: Department of Microbiology, Mount Sinai Hospital, Toronto, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Humar
authors.forename: P
authors.initials: P
authors.lastname: St Louis
authors.forename: T
authors.initials: T
authors.lastname: Mazzulli
authors.forename: A
authors.initials: A
authors.lastname: McGeer
authors.forename: J
authors.initials: J
authors.lastname: Lipton
authors.forename: H
authors.initials: H
authors.lastname: Messner
authors.forename: K S
authors.initials: KS
authors.lastname: MacDonald
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000276:immunology; D016207:Cytokines / Q000097:blood*; D003586:Cytomegalovirus Infections / Q000097:blood / Q000209:etiology* / Q000276:immunology; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008875:Middle Aged; D015999:Multivariate Analysis; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D014775:Virus Activation
chemical_list: D016207:Cytokines; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha