title: Sugar-substituted 2-azetidinones as cholesterol absorption inhibitors.
abstract: The asymmetric synthesis of a glucuronide conjugate of the 2-azetidinone cholesterol absorption inhibitor Sch 48461 was accomplished to confirm the structure of a metabolite isolated from in vivo sources. Key features of this article include the asymmetric synthesis of 2-azetidinones by Evan's chiral oxazolidinone methodology and glucuronide formation by a Mitsunobu protocol.
authors.affiliation: Schering-Plough Research Institute, Kenilworth, New Jersey 07033-0539, USA.
authors.forename: W D
authors.initials: WD
authors.lastname: Vaccaro
authors.forename: R
authors.initials: R
authors.lastname: Sher
authors.forename: H R
authors.initials: HR
authors.lastname: Davis
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000737:chemistry / Q000494:pharmacology*; D001384:Azetidines / Q000737:chemistry / Q000494:pharmacology*; D002241:Carbohydrates / Q000737:chemistry*; D006224:Cricetinae; D015394:Molecular Structure
chemical_list: D000924:Anticholesteremic Agents; D001384:Azetidines; D002241:Carbohydrates; C095487:1,4-bis(4-methoxyphenyl)-3-(3-phenylpropyl)-2-azetidinone