title: The -491 A/T polymorphism in the regulatory region of the apolipoprotein E gene and early-onset Alzheimer's disease.
abstract: The -491 polymorphism in the promoter region of the apolipoprotein E gene (APOE) has been suggested to be associated with increased risk for Alzheimer's disease (AD) independent of APOE status. We studied the association between the -491 polymorphism and risk for early-onset Alzheimer's disease in 99 Dutch and 78 Spanish patients. In patients with early-onset AD, we found no consistent relationship with a single allele of the -491 polymorphism. Linkage disequilibrium between the polymorphism and the APOE gene was found which most likely might explain the inconsistent findings.
authors.affiliation: Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands.
authors.forename: G
authors.initials: G
authors.lastname: Roks
authors.forename: M
authors.initials: M
authors.lastname: Cruts
authors.forename: M J
authors.initials: MJ
authors.lastname: Bullido
authors.forename: H
authors.initials: H
authors.lastname: Backhovens
authors.forename: M J
authors.initials: MJ
authors.lastname: Artiga
authors.forename: A
authors.initials: A
authors.lastname: Hofman
authors.forename: F
authors.initials: F
authors.lastname: Valdivieso
authors.forename: C
authors.initials: C
authors.lastname: Van Broeckhoven
authors.forename: C M
authors.initials: CM
authors.lastname: Van Duijn
mesh_terms: D017668:Age of Onset; D000483:Alleles; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics; D005787:Gene Frequency; D008040:Genetic Linkage; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008875:Middle Aged; D017354:Point Mutation; D011110:Polymorphism, Genetic; D012045:Regulatory Sequences, Nucleic Acid
chemical_list: D001057:Apolipoproteins E