Atopic dermatitis apparently caused by type 2 CD8+ T cells in an AIDS patient.
A patient with atopic dermatitis and acquired immune deficiency syndrome (AIDS) had demonstrated blood eosinophilia, high levels of serum IgE and intracytoplasmic IL-4 in the CD8+ but not in the CD4+ cells, decreased numbers of CD4+ cells, and low levels of IL-2 in both CD4+ and CD8+ cells. These results, reflecting a predominant influence of type 2 CD8+ cells, suggest they were involved in the genesis exacerbation of the patient's atopic dermatitis.
Ishii
N
N
Department of Dermatology, Yokohama City University School of Medicine, Japan.
Takahashi
K
K
Sugita
Y
Y
Nakajima
H
H
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D003876:Dermatitis, Atopic / Q000276:immunology*; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis; D015847:Interleukin-4 / Q000096:biosynthesis; D008297:Male; D008875:Middle Aged
D007376:Interleukin-2; D015847:Interleukin-4