[The effect of gidazepam on the activity of the sympatho-adrenal system in operators working under the usual and complicated conditions].
In healthy volunteers a single dose (0.05 g) of hydazepam does not change, but in subjects with psychogenic stress-reactions one-week course of the drug (0.05 g/24 h) intensifies to optimum activation of the sympathoadrenal system in response to standard operator load, inducing prevalent excretion of norepinephrine but not of epinephrine in the urine and maintains a high level of dopamine and DOPA excretion. In operators working in a state of hypercapnia and hyperthermia a single dose of hydazepam (0.05 g) blocks stress activation of the sympathoadrenal system. In a state of hyperthermia hydazepam normalizes the blood histamine and serotonin content. In all cases hydazepam improves the condition of the operators and the quality of their work, which allows it to be considered an effective and safe agent for the correction of stress-induced disorders in operators.
Morozov
I S
IS
Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
Barchukov
V G
VG
Riabichenko
V V
VV
Neznamov
G G
GG
Zhirnov
E N
EN
D000222:Adaptation, Physiological / Q000187:drug effects; D000293:Adolescent; D000311:Adrenal Glands / Q000187:drug effects* / Q000502:physiology; D000328:Adult; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001569:Benzodiazepines; D004311:Double-Blind Method; D005334:Fever / Q000097:blood / Q000503:physiopathology; D006801:Humans; D006935:Hypercapnia / Q000097:blood / Q000503:physiopathology; D008297:Male; D013315:Stress, Psychological / Q000097:blood / Q000503:physiopathology; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000502:physiology; D014937:Work / Q000502:physiology*
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; C077010:gidazepam
Vliianie gidazepama na aktivnost' simpato-adrenalovoĭ sistemy u operatorov pri rabote v obychnykh i oslozhnennykh usloviiakh.