title: Chloroquine inhibits HIV-1 replication in human peripheral blood lymphocytes.
abstract: Chloroquine has inhibitory effects on human immunodeficiency deficiency virus (HIV)-1 replication in human lymphocytes with an ED50 of 15 microM, which approximates the chloroquine plasma concentration generated in the acute treatment of malaria. Chloroquine has a parallel inhibitory effect on DNA replication in human lymphocytes, although the inhibitory effect on DNA replication is not as pronounced as is the drug inhibition of HIV-1 replication in the cells.
authors.affiliation: Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095-1682, USA. wpardrid@med1.medsch.ucla.edu
authors.forename: W M
authors.initials: WM
authors.lastname: Pardridge
authors.forename: J
authors.initials: J
authors.lastname: Yang
authors.forename: A
authors.initials: A
authors.lastname: Diagne
mesh_terms: D000962:Antimalarials / Q000097:blood / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002738:Chloroquine / Q000097:blood / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis; D004305:Dose-Response Relationship, Drug; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000821:virology*; D013997:Time Factors; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000962:Antimalarials; D002738:Chloroquine; D004247:DNA