The sarcoglycan complex in limb-girdle muscular dystrophy.
The involvement of the sarcoglycan complex in the pathogenesis of muscular dystrophy is becoming increasingly clear. Sarcoglycan gene mutations lead to four forms of autosomal recessive limb-girdle muscular dystrophy. Recent progress has been made with the identification of novel mutations and their correlations with disease. Through this research, a better understanding the molecular pathogenesis of limb-girdle muscular dystrophy has been gained. Finally, animal models are now being used to study viral-mediated gene transfer for the future treatment of this disease.
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Howard Hughes Medical Institute, Department of Physiology and Biophysics, University of Iowa College of Medicine, Iowa City 52242, USA.
Campbell
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D000818:Animals; D003598:Cytoskeletal Proteins / Q000235:genetics*; D004195:Disease Models, Animal; D015316:Genetic Therapy; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics*; D009136:Muscular Dystrophies / Q000209:etiology / Q000235:genetics* / Q000628:therapy; D009154:Mutation
D003598:Cytoskeletal Proteins; D008562:Membrane Glycoproteins