[Clinical and experimental study on treatment of chronic hepatitis B with yanggan aoping mixture].
OBJECTIVE
To assess the efficacy of Yanggan Aoping Mixture (YGAPM) in treating hepatitis B.


METHODS
Patients suffered from chronic hepatitis B were treated with YGAPM. Observe their short- and long-term efficacy and the change of serum hepatitis B virus marker. In experiment, the effect of YGAPM in treating rat's liver injury as well as HBV-infected tree shrew and duck HBV-infected ducks was observed.


RESULTS
In 79 cases of chronic persistant hepatitis, the markedly effective rate was 60.76%, and follow-up studies on 40 cases, the further rasied to 70.00%. In 73 cases of chronic active hepatitis, the markedly effective rate was 60.27%, and further raised to 62.50% in 32 follow-up cases. In the treatment group, 85 (71.43%) of the 119 cases with HBeAg-positive turned to negative. Whereas in the control group, only 40 (44.94%) of 89 HBeAg-positive cases turned to negative, P < 0.01. Results of experimental study showed that negative conversion rate of tree shrew infected with HBV marker was raised, while infected duck blood with duck HBV DNA was inhibited. Those compared with the control group separately, the difference was remarkably significant.


CONCLUSIONS
YGAPM is an effective drug in treating chronic hepatitis B, and it could effectively negative convert the HBV marker.
Yu
R Q
RQ
Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing.
Bi
J J
JJ
Wang
Q S
QS
D000293:Adolescent; D000328:Adult; D000818:Animals; D004279:DNA, Viral / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D018347:Hepadnaviridae Infections / Q000188:drug therapy; D015611:Hepatitis B Virus, Duck / Q000235:genetics; D006513:Hepatitis B e Antigens / Q000097:blood; D019694:Hepatitis B, Chronic / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D051381:Rats; D017207:Rats, Sprague-Dawley; D014418:Tupaiidae
D004279:DNA, Viral; D004365:Drugs, Chinese Herbal; D006513:Hepatitis B e Antigens