title: The synthesis of symmetrical spermine conjugates using solid-phase chemistry.
abstract: The utility of spermine, selectively functionalised and immobilised on a solid support by means of the Wang "oxycarbonyl" linker is demonstrated by the solid-phase synthesis of a number of spermine conjugates including the natural product and potent antihypertensive agent kukoamine. The synthesis opens up the area of solid-phase spermine chemistry and library generation based on the symmetrical spermine scaffold.
authors.affiliation: Department of Chemistry, University of Southampton, UK.
authors.forename: P
authors.initials: P
authors.lastname: Page
authors.forename: S
authors.initials: S
authors.lastname: Burrage
authors.forename: L
authors.initials: L
authors.lastname: Baldock
authors.forename: M
authors.initials: M
authors.lastname: Bradley
mesh_terms: D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013096:Spermine / Q000737:chemistry*
chemical_list: D013096:Spermine