Chemically-tagged Mitsunobu reagents for use in solution-phase chemical library synthesis.
A general method for high-throughput product purification of Mitsunobu reactions is described. Tagged phosphine and azodicarboxylate reagents are used to synthesize individual library members in solution-phase. Workup and purification are easily accomplished by post-reaction sequestration of the tagged reagents and reagent byproducts by a complementary functionalized ion exchange resin. The reagents are utilized in a 3 step library synthesis.
Starkey
G W
GW
Parallel Medicinal and Combinatorial Chemistry Unit, Searle Discovery Research Monsanto Life Sciences Company-U2E, Saint Louis, MO 63167, USA.
Parlow
J J
JJ
Flynn
D L
DL
D002625:Chemistry, Organic / Q000379:methods*; D019992:Databases as Topic; D003998:Dicarboxylic Acids / Q000737:chemistry*; D015195:Drug Design; D007202:Indicators and Reagents; D007475:Ion Exchange Resins; D010720:Phosphines; D012996:Solutions; D013329:Structure-Activity Relationship
D003998:Dicarboxylic Acids; D007202:Indicators and Reagents; D007475:Ion Exchange Resins; D010720:Phosphines; D012996:Solutions; C044646:phosphine