[Conservative treatment of bladder cancers with radiotherapy and concurrent chemotherapy: results and perspectives].
Therapeutic strategies for muscle invasive bladder cancer are currently evolving. Transurethral surgery followed by concurrent chemotherapy and radiotherapy is the best treatment for patients not suitable for radical cystectomy. This conservative approach may be proposed for operable patients with similar survival than after cystectomy. Intermediate evaluation of response is necessary, as response is the more discriminant prognostic factor for local control. Non responders would be assigned for immediate cystectomy. Morbidity and results of salvage cystectomy are poorly evaluated and probably depending from time from initial treatment and dose of radiation.
Chauvet
B
B
Institut Sainte-Catherine, Chemin du Lavarin, Avignon, France.
Davin
J L
JL
Alfonsi
M
M
Berger
C
C
Vincent
P
P
Reboul
F
F
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002295:Carcinoma, Transitional Cell / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D015653:Cystectomy / Q000009:adverse effects / Q000379:methods; D016002:Discriminant Analysis; D006801:Humans; D009017:Morbidity; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012307:Risk Factors; D016879:Salvage Therapy; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*
Traitement conservateur des cancers de vessie par radiothérapie et chimiothérapie concomitante: résultats et perspectives.