An investigation of the influence of the core material properties on the compression and properties of dry-coated tablets.
The effect of core material properties on the process of compression and physical properties of compression-coated tablets were investigated using microcrystalline cellulose as the coating material (mantle). Three model core materials: borosilicate glass, silicone rubber, and steel, each of different Young's modulus, were selected to give a range of core mechanical properties. Coated tablets were prepared using a single-punch press, with facilities for monitoring the compression cycle and analysis of data using the Heckel (1) equation. This analysis showed a considerable effect of different core materials on the compression process, (i) as an unanchored core, and (ii) due to core material type with differing Young's modulus.
Thomas
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WI
Pharmaceutical Development, Searle Pharmaceuticals, Northumberland, UK.
Rowley
G
G
Doveston
G
G
D002482:Cellulose; D019245:Compressive Strength; D003460:Crystallization; D016015:Logistic Models; D011312:Pressure; D013314:Stress, Mechanical; D013608:Tablets, Enteric-Coated; D013718:Tensile Strength
D013608:Tablets, Enteric-Coated; D002482:Cellulose