title: Synthesis and pharmacokinetic profile of 3-methoxymethyl cephalosporin prodrugs.
abstract: Preparation and biological activity of prodrug-type 3-methoxymethyl cephalosporins were described. From the mixtures, R- and S-prodrugs were separated and their absolute configurations were determined, and also their bioavailability was investigated.
authors.affiliation: Korea Research Institute of Chemical Technology, Yusong, Taejon, Korea.
authors.forename: M H
authors.initials: MH
authors.lastname: Jung
authors.forename: K W
authors.initials: KW
authors.lastname: Cho
authors.forename: J G
authors.initials: JG
authors.lastname: Park
authors.forename: Y H
authors.initials: YH
authors.lastname: Kim
mesh_terms: D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D002511:Cephalosporins / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D007408:Intestinal Absorption; D051379:Mice; D011355:Prodrugs / Q000138:chemical synthesis* / Q000493:pharmacokinetics
chemical_list: D002511:Cephalosporins; D011355:Prodrugs