title: Frontotemporal dementia genetics.
abstract: Frontotemporal dementia (FTD) is the most common syndrome in which the focus of neurodegeneration is the frontal lobes. FTD is frequently familial. It is also often due to a susceptibility locus on chromosome 17q21-22. Some 17q21-22-linked families have mutations in the tau gene and most have microscopically visible aggregates of hyperphosphorylated tau. Demonstrating that mutations in tau can produce neurodegeneration will necessitate a reassessment of the role of tau in the pathogenesis of the many diseases in which tau biology is disrupted.
authors.affiliation: Gallo Clinic & Research Center, University of California, San Francisco 94110, USA.
authors.forename: K C
authors.initials: KC
authors.lastname: Wilhelmsen
mesh_terms: D000368:Aged; D000595:Amino Acid Sequence / Q000235:genetics; D002886:Chromosomes, Human, Pair 17; D004252:DNA Mutational Analysis; D003704:Dementia / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D005625:Frontal Lobe / Q000473:pathology*; D008040:Genetic Linkage / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D009410:Nerve Degeneration / Q000235:genetics; D013702:Temporal Lobe / Q000473:pathology*; D016875:tau Proteins / Q000235:genetics
chemical_list: D016875:tau Proteins