title: European Collaborative Project on Affective Disorders: interactions between genetic and psychosocial vulnerability factors.
abstract: Despite strong evidence provided by genetic epidemiology of genetic involvement in the aetiology of bipolar and unipolar affective disorders, the exact nature of the predisposing gene(s) is still being investigated through linkage and association studies. The interaction of susceptibility genes and environmental factors in these diseases is also of fundamental importance and requires proper investigation. Interesting theories have recently been proposed examining the possible role of various chromosomal regions, candidate genes and mutations in affective disorders. Reliable multicentre-based methodology is currently being employed to examine these theories, with attention given to statistical analysis and the statistical power of the sample. The present article describes the European Collaborative Project on Affective Disorders (ECPAD) 'Interactions between genetic and psychosocial vulnerability factors', involving 15 European centres. A description is given of the association and family samples collected for the project and also the methodology used to analyse interactions in the gene-psychosocial environment. This material provides a powerful tool in the search for susceptibility genes in affective disorders and takes into account non-genetic aetiological factors.
authors.affiliation: Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, Belgium.
authors.forename: D
authors.initials: D
authors.lastname: Souery
authors.forename: O
authors.initials: O
authors.lastname: Lipp
authors.forename: A
authors.initials: A
authors.lastname: Serretti
authors.forename: B
authors.initials: B
authors.lastname: Mahieu
authors.forename: S K
authors.initials: SK
authors.lastname: Rivelli
authors.forename: C
authors.initials: C
authors.lastname: Cavallini
authors.forename: M
authors.initials: M
authors.lastname: Ackenheil
authors.forename: R
authors.initials: R
authors.lastname: Adolfsson
authors.forename: H
authors.initials: H
authors.lastname: Aschauer
authors.forename: D
authors.initials: D
authors.lastname: Blackwood
authors.forename: H
authors.initials: H
authors.lastname: Dam
authors.forename: B
authors.initials: B
authors.lastname: Delcoigne
authors.forename: V
authors.initials: V
authors.lastname: Demartelaer
authors.forename: D
authors.initials: D
authors.lastname: Dikeos
authors.forename: S
authors.initials: S
authors.lastname: Fuchshuber
authors.forename: M
authors.initials: M
authors.lastname: Heiden
authors.forename: A
authors.initials: A
authors.lastname: Jablensky
authors.forename: M
authors.initials: M
authors.lastname: Jakovljevic
authors.forename: L
authors.initials: L
authors.lastname: Kessing
authors.forename: B
authors.initials: B
authors.lastname: Lerer
authors.forename: A
authors.initials: A
authors.lastname: Macedo
authors.forename: T
authors.initials: T
authors.lastname: Mellerup
authors.forename: V
authors.initials: V
authors.lastname: Milanova
authors.forename: W
authors.initials: W
authors.lastname: Muir
authors.forename: J
authors.initials: J
authors.lastname: Mendlewicz
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001714:Bipolar Disorder / Q000453:epidemiology / Q000209:etiology / Q000235:genetics / Q000523:psychology; D016022:Case-Control Studies; D002874:Chromosome Mapping; D002877:Chromosomes, Human / Q000235:genetics; D004198:Disease Susceptibility; D004777:Environment; D005060:Europe / Q000453:epidemiology; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics / Q000523:psychology; D018377:Neurotransmitter Agents / Q000235:genetics / Q000378:metabolism; D010641:Phenotype; D011584:Psychology; D012494:Sampling Studies
chemical_list: D005819:Genetic Markers; D018377:Neurotransmitter Agents