[Investigation on in vivo metabolism of 6-methoxy n-butyl phthalide].
A GC-MS method for the investigation on the metabolism of 6-methoxy n-butyl phthalide (MBP) is described. After oral administration of MBP, the rat urine sample was collected, hydrolyzed with beta-glucuronidase, extracted and concentrated for TMS derivatization, and then analyzed by GC-MS. MBP and its six oxidative metabolites were determined in the 0-24 h rat urine sample. The mass spectra of the metabolites and their derivatives were presented and the in vivo metabolic pathway was discussed.
Peng
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SH
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
Zhou
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TH
D000818:Animals; D000927:Anticonvulsants / Q000378:metabolism*; D001572:Benzofurans / Q000378:metabolism*; D008401:Gas Chromatography-Mass Spectrometry; D008297:Male; D051381:Rats; D017208:Rats, Wistar
C115231:6-methoxy butyl phthalide; D000927:Anticonvulsants; D001572:Benzofurans