Improvement with disodium cromoglycate of neutrophil phagocytosis and respiratory burst activity in a patient with hyperimmunoglobulin E syndrome.
We report a case of hyperimmunoglobulin E syndrome (HIE) complicated by neutrophil deficiency which was successfully treated with oral administration of disodium cromoglycate. A 48-year-old Japanese man with HIE developed Streptococcus pneumoniae meningitis. Laboratory tests after the meningitis revealed persistent neutropenia (300-800/mm3) and defects of phagocytosis and bacterial killing by neutrophils. Administration of disodium cromoglycate was started, and neutrophil counts gradually increased to 1200-1600/mm3. The impaired neutrophil activities returned to normal. The patient improved clinically; during the 2-year treatment, he had only two brief episodes of the common cold. Disodium cromoglycate may have potential clinical use in the treatment of cases of HIE even with neutrophil deficiency.
Kojima
K
K
Department of Medicine, National Okayama Hospital, Japan.
Inoue
Y
Y
Katayama
Y
Y
Kataoka
M
M
Sunami
K
K
Fukuda
S
S
Sezaki
T
T
Omoto
E
E
Harada
M
M
D004205:Cromolyn Sodium / Q000627:therapeutic use*; D006401:Hematologic Agents / Q000627:therapeutic use*; D006801:Humans; D007589:Job Syndrome / Q000188:drug therapy*; D008297:Male; D016920:Meningitis, Bacterial / Q000150:complications / Q000382:microbiology; D008875:Middle Aged; D009503:Neutropenia / Q000188:drug therapy / Q000209:etiology; D009504:Neutrophils / Q000187:drug effects* / Q000502:physiology; D010587:Phagocytosis / Q000187:drug effects* / Q000502:physiology; D012123:Pulmonary Ventilation / Q000187:drug effects; D016897:Respiratory Burst / Q000187:drug effects*; D013296:Streptococcus pneumoniae
D006401:Hematologic Agents; D004205:Cromolyn Sodium