title: New antifungals selected by molecular topology.
abstract: Molecular topology has been applied to find the new lead antimycotic compounds. Among the selected compounds stands out 3,3'-(4,4'-Biphenylene)bis(2,5-diphenyl-2H-tetrazolium chloride), Benztropine mesylate and Dicyclopentamethylenethiuram disulphide, with minimum inhibitory concentrations between 1.6 and 2 micrograms/mL.
authors.affiliation: Unidad de Investigación de Diseño de Fármacos, Facultad de Farmacia, Universitat de Valencia, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Pastor
authors.forename: R
authors.initials: R
authors.lastname: García-Domenech
authors.forename: J
authors.initials: J
authors.lastname: Gálvez
authors.forename: S
authors.initials: S
authors.lastname: Wolski
authors.forename: M D
authors.initials: MD
authors.lastname: García
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D016002:Discriminant Analysis; D015195:Drug Design; D008826:Microbial Sensitivity Tests; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents