[Effect of estradiol on phosphoinositide composition of nuclear membranes of rat brain cells].
The effect of estradiol on phospholipids and particularly on phosphoinositides of nuclear membranes of rat brain cells at different stages of hormone action was investigated. It was shown that hormone leads to the elevation of phospholipids total amount at the primary and early stages of its action (1 and 4 h after estradiol injection, correspondingly). The increase of content of almost all individual fractions of phospholipids as well as phosphatidylinositol (i.e. monophosphoinositide) was detected. It is remarkable that the monophosphoinositides elevation takes place mainly due to the decrease of di- and especially of triphosphoinositide. The ratio of triphosphoinositide/monophosphoinositide decreases more than twice. It was concluded that the ratio of triphosphoinositide to monophosphoinositide may be a peculiar indicator of the status of nuclear membranes for the functioning of triphosphoinositide regulatory system.
Gevorkian
E S
ES
Yerevan State University, Armenia.
Iavroian
Zh V
ZhV
Artsruni
I G
IG
Akopian
N R
NR
Demirkhanian
L O
LO
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007425:Intracellular Membranes / Q000187:drug effects* / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats
D010716:Phosphatidylinositols; D010743:Phospholipids; D004958:Estradiol
Deĭstvie éstradiola na sostav fosfoinozitidov iadernykh membran kletok golovnogo mozga krys.