title: [A nondepolarizing muscle relaxant with rapidly developing and short-term action].
abstract: The pharmacological properties of the new nondepolarizing myorelaxant IEM-1213 and of its mixture with tercuronium were studied in experiments on anesthetized cats. Intravenous infusion of a blocking dose of IEM-1213 did not cause a change in the level of arterial pressure and blockade of the sympathetic ganglia but induced blockade of the heart muscarine receptors. The effect of IEM-1213 develops more rapidly and lasts for a shorter time than that of dithylin. Intravenous infusion of a mixture of IEM-1213 and tercuronium constituting 35 and 60% of the blocking dose of the former and, respectively, 35 and 20% of the blocking dose of the latter causes an effect similar in the time of its development to that of intravenous infusion of a total dose of IEM-1213 alone.
authors.affiliation: Laboratory of Comparative Pharmacology of Mediatory Systems, Sechenov Institute of Evolutional Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: A F
authors.initials: AF
authors.lastname: Danilov
authors.forename: E P
authors.initials: EP
authors.lastname: Zhabko
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D008725:Bis-Trimethylammonium Compounds / Q000494:pharmacology*; D002415:Cats; D010856:Columbidae; D004558:Electric Stimulation; D005730:Ganglionic Blockers / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects; D003473:Neuromuscular Nondepolarizing Agents / Q000494:pharmacology*; D010243:Paralysis / Q000139:chemically induced; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D013390:Succinylcholine / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects; D013997:Time Factors
chemical_list: D008725:Bis-Trimethylammonium Compounds; D005730:Ganglionic Blockers; C089301:IEM 1213; D003473:Neuromuscular Nondepolarizing Agents; D000644:Quaternary Ammonium Compounds; C013473:diadonium; C017744:terkuronii; D013390:Succinylcholine; D000218:Adamantane
vernacular_title: Nedepoliarizuiushchiĭ miorelaksant s bystro razvivaiushchimsia i kratkovremennym deĭstviem.