title: Effect of menthol on permeability of an optically active and racemic propranolol across guinea pig skin.
abstract: The effect of menthol on the percutaneous penetration of S(-)-propranolol (SPL) and racemic form of propranolol (RSPL) was investigated in vitro using excised abdominal skin of guinea pig. In the presence of menthol, the permeability coefficient of SPL was high compared with that of RSPL. The enhancement factors for SPL and RSPL were 2.12 and 0.85, respectively. The lag times for SPL and RSPL were reduced considerably in the presence of menthol compared to those for control (without enhancer). The present findings suggest the enantio-selective permeation of SPL across the guinea pig skin in the presence of menthol.
authors.affiliation: College of Pharmacy and Allied Health Professions, St. John's University, Jamaica, New York 11439, USA.
authors.forename: A
authors.initials: A
authors.lastname: Zahir
authors.forename: J R
authors.initials: JR
authors.lastname: Kunta
authors.forename: M A
authors.initials: MA
authors.lastname: Khan
authors.forename: I K
authors.initials: IK
authors.lastname: Reddy
mesh_terms: D000005:Abdomen; D000319:Adrenergic beta-Antagonists / Q000493:pharmacokinetics*; D000818:Animals; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008610:Menthol / Q000494:pharmacology*; D010539:Permeability; D011433:Propranolol / Q000493:pharmacokinetics*; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D013237:Stereoisomerism
chemical_list: D000319:Adrenergic beta-Antagonists; D008610:Menthol; D011433:Propranolol