title: Identification and developmental expression of Ci-isl, a homologue of vertebrate islet genes, in the ascidian Ciona intestinalis.
abstract: Here we describe the cloning and expression pattern of Ci-isl, a homologue of vertebrate genes, in the ascidian. Early in development, Ci-isl expression occurs in the primordia of palps and brain vesicle, then in the tailbud embryo it is transiently extended to the notochord cells. At larva stage, the expression is down-regulated in the notochord, and it persists predominantly in the compartments of the nervous system. These observations indicate that also in invertebrates, islet genes show an expression pattern during differentiation of the nervous system.
authors.affiliation: Laboratory of Cell Biology, Stazione Zoologica 'A. Dohrn', Villa Comunale, 80121, Naples, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Giuliano
authors.forename: R
authors.initials: R
authors.lastname: Marino
authors.forename: M R
authors.initials: MR
authors.lastname: Pinto
authors.forename: R
authors.initials: R
authors.lastname: De Santis
mesh_terms: D000818:Animals; D002938:Ciona intestinalis / Q000196:embryology / Q000235:genetics* / Q000254:growth & development; D003001:Cloning, Molecular; D018507:Gene Expression Regulation, Developmental; D005796:Genes; D018398:Homeodomain Proteins / Q000096:biosynthesis / Q000235:genetics*; D017403:In Situ Hybridization; D060850:LIM-Homeodomain Proteins; D007814:Larva; D008322:Mammals / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity; D014157:Transcription Factors
chemical_list: D018398:Homeodomain Proteins; D060850:LIM-Homeodomain Proteins; D009419:Nerve Tissue Proteins; D014157:Transcription Factors; C063843:insulin gene enhancer binding protein Isl-1; C117383:isl protein, Ciona intestinalis