title: Adenosine deaminase inhibitors. Synthesis and biological evaluation of aralkyladenines (ARADS).
abstract: Several 9-aralkyladenines have been prepared and their ADA inhibitory activity was determined. A minimum of two carbon atoms separating the aromatic ring from the adenine-bearing carbon (C3') was found essential for potent activity.
authors.affiliation: Department of Biomedical Sciences, University of Rhode Island, Kingston 02881-0809, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Curtis
authors.forename: V
authors.initials: V
authors.lastname: Varkhedkar
authors.forename: P V
authors.initials: PV
authors.lastname: Pragnacharyulu
authors.forename: E
authors.initials: E
authors.lastname: Abushanab
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology*; D058892:Adenosine Deaminase Inhibitors; D004341:Drug Evaluation; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D058892:Adenosine Deaminase Inhibitors; D004791:Enzyme Inhibitors; D000225:Adenine