Non-N-methyl-D-aspartate receptors may mediate the transmission of emetic signals between visceral vagal afferents and the solitary nucleus in dogs.
The effects of the N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists MK-801 and NBQX, respectively, on salivary secretion and retching induced by vagal stimulation were studied in decerebrate dogs. Vagal stimulation induced an increase in salivary secretion and fictive retching. Intra-4th ventricular application of vehicle or MK-801 did not change either response, while NBQX completely abolished both responses. These results suggest that non-NMDA receptors mediate both responses in the solitary nucleus.
Furukawa
N
N
Department of Physiology, Kawasaki Medical School, Japan. furukawa@med.kawasaki-m.ac.jp
Hatano
M
M
Fukuda
H
H
Koga
T
T
D000758:Anesthesia; D000818:Animals; D003655:Decerebrate State; D016291:Dizocilpine Maleate / Q000494:pharmacology; D004285:Dogs; D004558:Electric Stimulation; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D008036:Lingual Nerve / Q000502:physiology; D010791:Phrenic Nerve / Q000502:physiology; D011810:Quinoxalines / Q000494:pharmacology; D011930:Reaction Time / Q000502:physiology; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000502:physiology*; D012472:Salivation / Q000187:drug effects / Q000502:physiology; D017552:Solitary Nucleus / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*; D014630:Vagus Nerve / Q000502:physiology*; D014839:Vomiting / Q000503:physiopathology*
D018691:Excitatory Amino Acid Antagonists; D011810:Quinoxalines; D018091:Receptors, AMPA; D016194:Receptors, N-Methyl-D-Aspartate; C062865:2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline; D016291:Dizocilpine Maleate