title: [Does some relation exist in the size and histological composition of the prostate?].
abstract: OBJECTIVE
  To determine if the histological composition of the prostate-the proportion of glands and stroma-depends on its size.
  
  
  METHODS
  Prostate volume was determined by abdominal US; transurethral biopsy of the prostate was performed in 22 patients (mean age 64.8 years) with BPH or bladder tumor. Morphometric analysis of a fragment of the prostate was performed using light and electron microscopy. The stroma-epithelial ratio (SER) and the density of prostatic vascularization (DPV), and the nuclear and cellular areas of 5 epithelial cells in each case, were determined. The ratio of the sum of granular to cellular areas (secreto-cellular ratio), and the nuclear-cytoplasmic ratio (NCR) were determined. The pearson coefficient and linear regression equation that best correlated the prostate volume and the rest of the variables.
  
  
  RESULTS
  The mean SER was 4:1 and the DPV was 15.18 vessels/mm2. The cellular and nuclear areas were 79.6 and 21.2 mu2, respectively. The secreto-cellular ratio was 0.083 and the NCR was 0.28. The prostate volume showed no mathematical relationship with SER (r = 0.016, p = 0.9) or DPV (r = 0.026, p = 0.9). Only a random association between the US prostate volume and the cellular and nuclear areas, and the secreto-cellular and NCR could be observed.
  
  
  CONCLUSIONS
  The histological composition of the prostate cannot be determined by the US prostate volume.
authors.affiliation: Servicio de Urología, Hospital Universitario de Getafe, Madrid, España.
authors.forename: A
authors.initials: A
authors.lastname: Páez Borda
authors.forename: M
authors.initials: M
authors.lastname: Luján Galán
authors.forename: E
authors.initials: E
authors.lastname: Martín Oses
authors.forename: L
authors.initials: L
authors.lastname: Llanes González
authors.forename: A
authors.initials: A
authors.lastname: Berenguer Sánchez
mesh_terms: D000368:Aged; D003594:Cytoplasmic Granules; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D011467:Prostate / Q000098:blood supply / Q000473:pathology* / Q000648:ultrastructure; D011470:Prostatic Hyperplasia / Q000000981:diagnostic imaging / Q000473:pathology*; D014463:Ultrasonography
vernacular_title: Existe alguna relación entre el tamaño y la composición histológica de la próstata?