Diimidazo[1,2-c:4',5'-e]pyrimidines: N6-N1 conformationally restricted adenosines.
Tethering the N6-substituents of N6-substituted adenosines to N1 has resulted in a series of conformationally restricted adenosine analogues. The resultant diimidazo[1,2-c:4',5'-e]pyrimidines were shown to be adenosine A1 selective.
Camp
D
D
Queensland Pharmaceutical Research Institute, Griffith University, Brisbane, Australia.
Li
Y
Y
McCluskey
A
A
Moni
R W
RW
Quinn
R J
RJ
D000818:Animals; D001921:Brain / Q000378:metabolism; D002478:Cells, Cultured; D003342:Corpus Striatum / Q000378:metabolism; D006801:Humans; D008956:Models, Chemical; D010660:Phenylisopropyladenosine / Q000031:analogs & derivatives* / Q000378:metabolism; D058906:Purinergic P1 Receptor Agonists; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000378:metabolism*; D051381:Rats; D018047:Receptors, Purinergic P1 / Q000378:metabolism
D058906:Purinergic P1 Receptor Agonists; D011743:Pyrimidines; D018047:Receptors, Purinergic P1; D010660:Phenylisopropyladenosine