title: Preparation of alpha-keto ester enol acetates as potential prodrugs of human neutrophil elastase inhibitors.
abstract: Enol acetates of a-keto esters with E configuration were prepared as potential prodrugs for human neutrophil elastase (HNE) inhibitors.
authors.affiliation: Hoechst Marion Roussel, Cincinnati, Ohio 45215, USA.
authors.forename: J P
authors.initials: JP
authors.lastname: Burkhart
authors.forename: S
authors.initials: S
authors.lastname: Mehdi
authors.forename: J R
authors.initials: JR
authors.lastname: Koehl
authors.forename: M R
authors.initials: MR
authors.lastname: Angelastro
authors.forename: P
authors.initials: P
authors.lastname: Bey
authors.forename: N P
authors.initials: NP
authors.lastname: Peet
mesh_terms: D000085:Acetates / Q000737:chemistry*; D004952:Esters; D006801:Humans; D019272:Leukocyte Elastase / Q000037:antagonists & inhibitors*; D011355:Prodrugs / Q000138:chemical synthesis* / Q000494:pharmacology; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000085:Acetates; D004952:Esters; D011355:Prodrugs; D011480:Protease Inhibitors; D019272:Leukocyte Elastase