title: Sex differences in patients with mesial temporal lobe epilepsy.
abstract: Possible sex differences in the pattern of interictal hypometabolism were investigated, and also seizure spread in patients with mesial temporal lobe epilepsy (n=48) and hippocampal sclerosis (MTLE). Male patients (n=21) more often had a frontal lobe hypometabolism ipsilateral to the seizure onset (p<0.0001) and a spread of epileptiform activity to this region (p=0.001). By contrast, female patients more often exhibited hypometabolism (p=0.0052) and an ictal spread to the contralateral temporal lobe (p=0.0097). These findings suggest sex differences in spatial distribution of brain dysfunction in MTLE, perhaps reflecting sexual dimorphism in regional cerebral connectivity.
authors.affiliation: Department of Human Brain Research, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden. ivanka.savic-berglund@neuro.ki.se
authors.forename: I
authors.initials: I
authors.lastname: Savic
authors.forename: J
authors.initials: J
authors.lastname: Engel
mesh_terms: D000328:Adult; D001921:Brain / Q000002:abnormalities / Q000378:metabolism / Q000503:physiopathology; D004833:Epilepsy, Temporal Lobe / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008659:Metabolic Diseases / Q000378:metabolism; D012189:Retrospective Studies; D012727:Sex Characteristics; D014055:Tomography, Emission-Computed