title: Methotrexate-induced hepatic necrosis requiring liver transplantation in a patient with rheumatoid arthritis.
abstract: MTX-induced hepatic injury and liver enzyme elevations have been demonstrated after treatment of leukemia, gestational disease and during treatment of psoriasis and rheumatoid arthritis. A 40-year-old man with a long standing history of rheumatoid arthritis was treated with MTX over a 6 month period and developed an overwhelming hepatic necrosis. He was successfully transplanted.
authors.affiliation: Department of Surgery, University of Minnesota, Minneapolis, USA.
authors.forename: N S
authors.initials: NS
authors.lastname: Hakim
authors.forename: B
authors.initials: B
authors.lastname: Kobienia
authors.forename: E
authors.initials: E
authors.lastname: Benedetti
authors.forename: J
authors.initials: J
authors.lastname: Bloomer
authors.forename: W D
authors.initials: WD
authors.lastname: Payne
mesh_terms: D000328:Adult; D018501:Antirheumatic Agents / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy*; D056486:Chemical and Drug Induced Liver Injury; D006801:Humans; D008107:Liver Diseases / Q000150:complications / Q000473:pathology / Q000601:surgery; D016031:Liver Transplantation; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D009336:Necrosis
chemical_list: D018501:Antirheumatic Agents; D008727:Methotrexate