Two examples of rapid and simple drug analysis in pharmaceutical formulations using capillary electrophoresis: naphazoline, dexamethasone and benzalkonium in nose drops and nystatin in an oily suspension.
Capillary electrophoresis is a versatile tool in pharmaceutical analysis. In the course of a revision of the "Standardrezepturen", a German formula of standard dispensings for preparation in pharmacies, this technique has been applied to drug analysis in pharmaceutical formulations. The present paper deals with two different examples. First, naphazoline, dexamethasone and the preservative benzalkonium are quantified in nose drops without any sample preparation. Second, the antifungal antibiotic nystatin is quantified using nonaqueous capillary electrophoresis in methanol after sample preparation from an oily suspension.
Raith
K
K
Martin Luther University Halle, Department of Pharmacy, Institute of Pharmaceutics and Biopharmaceutics, Halle (Saale), Germany.
Althoff
E
E
Banse
J
J
Neidhardt
H
H
Neubert
R H
RH
D000281:Administration, Intranasal; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000032:analysis; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000032:analysis; D000935:Antifungal Agents / Q000008:administration & dosage / Q000032:analysis; D001548:Benzalkonium Compounds / Q000008:administration & dosage / Q000032:analysis; D003907:Dexamethasone / Q000008:administration & dosage / Q000032:analysis; D019075:Electrophoresis, Capillary / Q000379:methods*; D005938:Glucocorticoids; D009278:Naphazoline / Q000008:administration & dosage / Q000032:analysis; D014663:Nasal Decongestants / Q000008:administration & dosage / Q000032:analysis; D009761:Nystatin / Q000008:administration & dosage / Q000032:analysis; D013535:Suspensions
D000891:Anti-Infective Agents, Local; D000893:Anti-Inflammatory Agents; D000935:Antifungal Agents; D001548:Benzalkonium Compounds; D005938:Glucocorticoids; D014663:Nasal Decongestants; D013535:Suspensions; D009761:Nystatin; D003907:Dexamethasone; D009278:Naphazoline