[Separate and combined effects of ionizing radiation and cyclophosphamide on thymus-dependent humoral immune response].
The total exposure of gamma-irradiation, (1-2 Gy) or intraperitoneally injection of cyclophosphamide (10-50 mg/kg) resulted in the dose-dependent inhibition of humoral immune response. The immunosuppression was expressed to a greater degree in lymphatic nodules, than in spleen. The combined action of these factors showed the effect of synergism. The injection of cyclophosphamide in mice neutralized the effect of antibody genesis induced by low dose irradiation (0.1 Gy).
Sharetskiĭ
A N
AN
Medical Radiological Research Center, Russian Academy of Medical Sciences, Obninsk.
Surinov
B P
BP
Abramova
M R
MR
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects / Q000528:radiation effects*; D003520:Cyclophosphamide / Q000494:pharmacology*; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008198:Lymph Nodes / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013154:Spleen / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects*
D007166:Immunosuppressive Agents; D003520:Cyclophosphamide
Razdel'noe i sochetannoe vozdeĭstvie ioniziruiushcpheĭ radiatsii i tsiklofosfana na timuszavisimyĭ gumoral'nyĭ immunnyĭ otvet.