Difference in microbes contaminating pancreatic necrosis in biliary and alcoholic pancreatitis.
CONCLUSIONS
There are differences in the microbiology of infected pancreatic necrosis in alcoholic and biliary pancreatitis. One possible explanation may be different routes of contamination.


BACKGROUND
Infection is a severe complication in acute pancreatitis. Bacteria are found in 40-70% of all patients suffering from necrotizing pancreatitis. We investigated whether there were any differences in microbes isolated from pancreatic necrosis in biliary and alcoholic pancreatitis.


METHODS
Microbiological tests were conducted on necrosis taken at the operation for pancreatitis with the etiology of (group A) alcoholic pancreatitis (n = 47) and (group B) biliary pancreatitis (n = 23). Patients with simultaneous cholecystitis were excluded. The time from the first symptoms to the operation or the extent of necrosis did not differ between the groups.


RESULTS
Microbes were isolated more often in the cultures from group B than group A (17/23 = 74% vs 15/47 = 32%, p = 0.001). The most common were Gram-positive bacteria in group A and Gram-negative bacteria in group B. From the first week, from the onset of symptoms to the operation. Gram-negative bacteria were isolated significantly more often in the cultures from group B patients than from group A patients (8/10 = 80% vs 1/5 = 20%, p = 0.04). In multivariate analysis, we found that biliary pancreatitis was an independent risk factor (adds ratio 5.5, 95% confidence interval [CI] 0.59-52.10) of contamination of necrosis with Gram-negative bacteria.
Räty
S
S
Department of Surgery, Tampere University Hospital, Finland.
Sand
J
J
Nordback
I
I
D000328:Adult; D000368:Aged; D002175:Candida / Q000302:isolation & purification; D002769:Cholelithiasis / Q000150:complications; D005260:Female; D006090:Gram-Negative Bacteria / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009336:Necrosis; D010195:Pancreatitis / Q000209:etiology / Q000382:microbiology* / Q000473:pathology; D019283:Pancreatitis, Acute Necrotizing / Q000382:microbiology / Q000473:pathology; D019512:Pancreatitis, Alcoholic / Q000382:microbiology* / Q000473:pathology; D012189:Retrospective Studies; D012307:Risk Factors