title: Nissen fundoplication may induce gastric myoelectrical disturbance in children.
abstract: BACKGROUND
  Recurrent vomiting with failure to thrive is a common problem in neurologically impaired children. Many undergo fundoplication to control the underlying gastroesophageal reflux, but the results of surgery are not always satisfactory, and postoperative retching may be a major problem. Retching is part of the emetic reflex and is associated with nausea, which is itself associated with disturbed gastric electrical control activity, resulting in a gastric dysrhythmia.
  
  
  METHODS
  By recording gastric electrical control activity before and after Nissen fundoplication using the noninvasive technique of surface electrogastrography, the authors have shown that (1) Neurologically impaired children with gastroesophageal reflux more commonly have a preexisting gastric dysrhythmia (65% neurologically impaired v 20% neurologically normal children with gastroesophageal reflux, P<.05), (2) Children who retch preoperatively are three times more likely to retch postoperatively, and (3) 25% of neurologically impaired children may start to retch postoperatively for the first time.
  
  
  CONCLUSIONS
  The authors propose that in neurologically impaired children, loss of central inhibitory mechanisms may result in inappropriate activation of the emetic reflex, which may be heightened by antireflux surgery.
authors.affiliation: Department of Surgery and Gastroenterology, Institute of Child Health, London, England.
authors.forename: C A
authors.initials: CA
authors.lastname: Richards
authors.forename: P L
authors.initials: PL
authors.lastname: Andrews
authors.forename: L
authors.initials: L
authors.lastname: Spitz
authors.forename: P J
authors.initials: PJ
authors.lastname: Milla
mesh_terms: D002648:Child; D002675:Child, Preschool; D004576:Electromyography; D018662:Fundoplication; D005764:Gastroesophageal Reflux / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D007223:Infant; D011184:Postoperative Period; D012815:Signal Processing, Computer-Assisted; D013270:Stomach / Q000503:physiopathology*; D014839:Vomiting / Q000503:physiopathology