In vitro release of amoxycillin from lipophilic suppositories.
The in vitro release characteristics of amoxycillin from different lipophilic suppository bases were investigated using the USP rotating basket method. Suppositories containing 250 mg amoxycillin were prepared in theobroma oil and in the semi-synthetic bases Witepsol W35, Suppocire A32, Novata BD, and Novata 299. Both freshly prepared and 1-month-old suppositories were tested. Analysis of amoxycillin was performed using a validated high-performance liquid chromatographic (HPLC) technique. Release profiles differed significantly between bases, with the greatest amount of amoxycillin being released from both newly made and 1-month-old Novata BD bases (87.57 +/- 8.18 and 99.66 +/- 6.63%, respectively), and the lowest amount released from the newly manufactured theobroma suppositories (8.82 +/- 0.75%) and the 1-month-old Suppocire A32 suppositories (7.78 +/- 0.27%).
Webster
J A
JA
School of Pharmaceutical Sciences, Rhodes University, Grahamstown, South Africa.
Dowse
R
R
Walker
R B
RB
D000658:Amoxicillin / Q000008:administration & dosage* / Q000302:isolation & purification / Q000493:pharmacokinetics*; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D004339:Drug Compounding / Q000379:methods; D006801:Humans; D066298:In Vitro Techniques; D008055:Lipids; D010406:Penicillins / Q000008:administration & dosage* / Q000302:isolation & purification / Q000493:pharmacokinetics*; D014677:Pharmaceutical Vehicles; D013488:Suppositories
D008055:Lipids; D010406:Penicillins; D014677:Pharmaceutical Vehicles; D013488:Suppositories; D000658:Amoxicillin