title: Synthesis and biological evaluation of a water soluble phosphate prodrug of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP).
abstract: With the aim of improving its biological and pharmaceutical profiles, two water soluble phosphate prodrugs of 3-AP, 3a and 3b were prepared. The detailed synthesis and the preliminary evaluation of these prodrugs are described.
authors.affiliation: Vion Pharmaceutical, Inc., Four Science Park, New Haven, CT 06511, USA.
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: X
authors.initials: X
authors.lastname: Luo
authors.forename: Q
authors.initials: Q
authors.lastname: Wang
authors.forename: L M
authors.initials: LM
authors.lastname: Zheng
authors.forename: I
authors.initials: I
authors.lastname: King
authors.forename: T W
authors.initials: TW
authors.lastname: Doyle
authors.forename: S H
authors.initials: SH
authors.lastname: Chen
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004285:Dogs; D004355:Drug Stability; D051379:Mice; D008807:Mice, Inbred BALB C; D011355:Prodrugs / Q000138:chemical synthesis* / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D012995:Solubility; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D011355:Prodrugs; D011725:Pyridines; D013882:Thiosemicarbazones; C078157:3-aminopyridine-2-carboxaldehyde thiosemicarbazone