title: PDE4 inhibitors: new xanthine analogues.
abstract: Novel xanthine analogues are described which are selective PDE4 inhibitors with improved therapeutic potential over theophylline.
authors.affiliation: Chiroscience Ltd, Cambridge Science Park, UK. johnmontana@chiroscience.com
authors.forename: J G
authors.initials: JG
authors.lastname: Montana
authors.forename: N
authors.initials: N
authors.lastname: Cooper
authors.forename: H J
authors.initials: HJ
authors.lastname: Dyke
authors.forename: L
authors.initials: L
authors.lastname: Gowers
authors.forename: J P
authors.initials: JP
authors.lastname: Gregory
authors.forename: P G
authors.initials: PG
authors.lastname: Hellewell
authors.forename: J
authors.initials: J
authors.lastname: Miotla
authors.forename: K
authors.initials: K
authors.lastname: Morris
authors.forename: R
authors.initials: R
authors.lastname: Naylor
authors.forename: B
authors.initials: B
authors.lastname: Tuladhar
authors.forename: J B
authors.initials: JB
authors.lastname: Warneck
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000818:Animals; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D004802:Eosinophilia / Q000188:drug therapy; D005289:Ferrets; D006168:Guinea Pigs; D010726:Phosphodiesterase Inhibitors / Q000009:adverse effects / Q000138:chemical synthesis* / Q000494:pharmacology; D012871:Skin Diseases / Q000188:drug therapy; D013806:Theophylline / Q000494:pharmacology; D014839:Vomiting / Q000139:chemically induced; D014970:Xanthines / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D010726:Phosphodiesterase Inhibitors; D014970:Xanthines; D013806:Theophylline; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4