title: Cost-effectiveness impact of iron dextran on hemodialysis patients' use of epoetin alfa and blood.
abstract: The cost-effectiveness impact of iron dextran administration on the use of epoetin alfa and blood in hemodialysis patients was studied. Subjects were ambulatory hemodialysis patients who had been receiving hemodialysis for at least six months before the start of an iron dextran protocol and who had been given epoetin alfa for at least four of those six months. Clinical data were collected for six months before and six months after the protocol was implemented. Successful treatment was defined as a hematocrit of 33-36%, a transferrin saturation of >10%, a ferritin concentration of >100 ng/mL, and no blood use except for acute blood loss. A total of 33 patients completed the study. Fifty units of blood were used in the first six months and nine units in the second six months. There was significant improvement in mean hematocrit, ferritin, and transferrin saturation values after the protocol began. Average epoetin alfa doses did not change significantly. There was significant improvement in success rates for ferritin and blood use and in the overall success rate. Ten patients met all success criteria in the preprotocol period, versus 27 in the postprotocol period. Monthly cost-effectiveness analysis for the preprotocol and postprotocol periods indicated costs of $1350 and $526, per successful treatment, respectively. The incremental cost-effectiveness of iron dextran was $42 per successful treatment. Iron dextran improved iron indices and reduced the need for blood transfusions but did not reduce the average dose of epoetin alfa. The additional cost of therapy per month seemed justified by the clinical benefits.
authors.affiliation: Department of Pharmacy, Pocatello Regional Medical Center, ID 83201, USA. tnkh28a@prodigy.com
authors.forename: P S
authors.initials: PS
authors.lastname: Driver
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000188:drug therapy / Q000191:economics / Q000517:prevention & control; D001803:Blood Transfusion / Q000191:economics*; D003362:Cost-Benefit Analysis; D000068817:Epoetin Alfa; D004921:Erythropoietin / Q000191:economics* / Q000627:therapeutic use; D005260:Female; D005293:Ferritins / Q000097:blood; D006397:Hematinics / Q000191:economics* / Q000627:therapeutic use; D006400:Hematocrit; D006801:Humans; D007061:Idaho; D007505:Iron-Dextran Complex / Q000191:economics* / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000150:complications / Q000191:economics / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins; D006435:Renal Dialysis; D014168:Transferrin / Q000032:analysis
chemical_list: D006397:Hematinics; D011994:Recombinant Proteins; D014168:Transferrin; D004921:Erythropoietin; D000068817:Epoetin Alfa; D007505:Iron-Dextran Complex; D005293:Ferritins