title: In-111 labeled leukocyte scintigraphy in patients with suspected inflammation after failed antibiotic therapy.
abstract: In-111 labeled leukocyte scintigraphy (In-111 WBC scan) was performed in 16 patients with inflammation suspected on the basis of laboratory findings, symptoms, and diagnostic imaging, but who had failed antibiotic therapy. In-111 WBC scans revealed an abnormal focus of radiotracer activity (positive scans) in five of 16 patients. No correlation was found between the peripheral WBC count and accumulation of In-111 WBC. Inflammatory disease suspected on the basis of the CRP level should be considered when In-111 WBC scanning results in negative findings. Our results indicated that In-111 WBC scanning has low sensitivity after antibiotic therapy. Selection of patients on the basis of persistent elevation of CRP may be valuable.
authors.affiliation: Department of Radiology, Kansai Medical University, Moriguchi, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Nasu
authors.forename: K
authors.initials: K
authors.lastname: Akagi
authors.forename: T
authors.initials: T
authors.lastname: Murata
authors.forename: K
authors.initials: K
authors.lastname: Uokawa
authors.forename: H
authors.initials: H
authors.lastname: Isoda
authors.forename: Y
authors.initials: Y
authors.lastname: Itagaki
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D007223:Infant; D007249:Inflammation / Q000000981:diagnostic imaging* / Q000188:drug therapy; D007962:Leukocytes / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D017211:Treatment Failure
chemical_list: D000900:Anti-Bacterial Agents; D007205:Indium Radioisotopes