Immunoexpression of mutant p53 and human papillomavirus related E6 oncoprotein in anal malignancies.
Immunohistochemical expression of mutant p53 protein and human papillomavirus (HPV) 16 and 18 related E6 oncoprotein was studied in 36 biopsy proved anal cancers. Mutant p53 was detected in 61.1% cases. HPV 16 and 18 E6 protein was expressed in 22.2% cases, all of which were squamous cell carcinomas. Coexpression of both mutant p53 and E6 protein was found in only 5 cases (13.8%). In HPV 16/18 positive anal tumors, the degradation of p53 is accelerated by viral E6 oncoprotein. In HPV negative tumors, however, other mutagenic factors probably play a role in carcinogenesis.
Gupta
S
S
Division of Cytopathology, Institute of Cytology and Preventive Oncology (ICMR), New Delhi, India.
Sharma
B K
BK
D000328:Adult; D000368:Aged; D001005:Anus Neoplasms / Q000209:etiology / Q000235:genetics* / Q000821:virology*; D004268:DNA-Binding Proteins; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009856:Oncogene Proteins, Viral / Q000378:metabolism*; D027383:Papillomaviridae / Q000378:metabolism / Q000472:pathogenicity; D012097:Repressor Proteins; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000378:metabolism
D004268:DNA-Binding Proteins; C068651:E6 protein, Human papillomavirus type 16; C052603:E6 protein, Human papillomavirus type 18; D009856:Oncogene Proteins, Viral; D012097:Repressor Proteins; D016159:Tumor Suppressor Protein p53