title: New superselective intra-arterial infusion via superficial temporal artery for cancer of the tongue and tumour tissue platinum concentration after carboplatin (CBDCA) infusion.
abstract: We developed a new technique of superselective intra-arterial chemotherapy for tongue cancer using a modified (1.35 mm) angiographic catheter. The catheter was confirmed to be inserted into the lingual artery by the new technique. We measured the platinum concentrations in resected tumour tissues after infusion of carboplatin (CBDCA) at 20 mg/m2 over 30 min from 30 min before tumour resection in 12 patients with cancer of the tongue (6 patients: superselective intra-arterial infusion; 6 patients: conventional intra-arterial infusion). The mean platinum concentration in tumour tissue was 10.5 +/- 1.2 micrograms/g wet, which was more than twice higher than, and significantly different from, 4.3 +/- 3.8 micrograms/g wet by the conventional intra-arterial infusion method. This new superselective intra-arterial infusion method allows direct infusion of the anticancer agent into the artery supplying the tumour and is expected to become a new therapeutic modality for cancer of the tongue.
authors.affiliation: Department of Oral Surgery, Nagoya University School of Medicine, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Tohnai
authors.forename: N
authors.initials: N
authors.lastname: Fuwa
authors.forename: Y
authors.initials: Y
authors.lastname: Hayashi
authors.forename: R
authors.initials: R
authors.lastname: Kaneko
authors.forename: Y
authors.initials: Y
authors.lastname: Tomaru
authors.forename: Y
authors.initials: Y
authors.lastname: Hibino
authors.forename: M
authors.initials: M
authors.lastname: Ueda
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000378:metabolism; D016190:Carboplatin / Q000008:administration & dosage* / Q000378:metabolism; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000379:methods; D013699:Temporal Arteries; D014062:Tongue Neoplasms / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D016190:Carboplatin