New bronchodilators selected by molecular topology.
Molecular topology has been applied to find new lead compounds with bronchodilator activity. Among the selected compounds stands out 3-(1H-tetrazol-5yl)-9H-thioxanthene-9 -one-10,10-dioxide, anthrarobin, 9-oxo-9H-thioxantene-3-carboxylic-10,10-dioxide acid, acenocoumarol and griseofulvin, with a percentage of relaxation, at 0.1 mM, of 91, 92, 85, 69, and 74%, respectively. Theophylline shows a correspondent value of 77% (Emax = 100% at 1 mM).
Ríos-Santamarina
I
I
Unidad de Investigación de Diseño de Fármacos, Facultad de Farmacia, Universitat de Valencia, Burjassot, Spain.
García-Domenech
R
R
Gálvez
J
J
Cortijo
J
J
Santamaria
P
P
Morcillo
E
E
D000818:Animals; D001993:Bronchodilator Agents / Q000737:chemistry / Q000494:pharmacology*; D016002:Discriminant Analysis; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects; D013329:Structure-Activity Relationship; D014132:Trachea / Q000187:drug effects / Q000502:physiology
D001993:Bronchodilator Agents