Control of vascular smooth muscle cell growth and its implication in atherosclerosis and restenosis (review).
Abnormal proliferation of vascular smooth muscle cells (SMCs) is thought to contribute to neointimal thickening during spontaneous atherosclerosis and vessel renarrowing (restenosis) after angioplasty. This review will focus on the mechanisms underlying cell-cycle control in SMCs and its implication in atherosclerosis and restenosis. Therapeutic approaches that targeted specific cell-cycle control genes or growth regulatory molecules which effectively inhibited neointimal lesion formation will also be discussed.
Andres
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Division of Cardiovascular Research, St. Elizabeth's Medical Center, Boston, MA 02135, USA.
D001161:Arteriosclerosis / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects / Q000235:genetics; D018816:Genes, cdc / Q000187:drug effects; D006083:Graft Occlusion, Vascular / Q000473:pathology*; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000473:pathology*; D016376:Oligonucleotides, Antisense / Q000494:pharmacology / Q000627:therapeutic use
D016376:Oligonucleotides, Antisense