Design and synthesis of isoxazole and isoxazoline linkage for replacement of nucleotide phosphodiester.
Synthetic routes for oligonucleotides which have isoxazoline or isoxazole linkage have been developed, and di- and tri-nucleotides with thymine bases have been prepared.
Kim
S J
SJ
Department of Chemistry, Pohang University of Science and Technology, Korea.
Lee
J Y
JY
Kim
B H
BH
D015195:Drug Design; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D013936:Thymidine / Q000737:chemistry
D007555:Isoxazoles; D009841:Oligonucleotides; D013936:Thymidine