Synthesis and in vitro cancer cell growth inhibitory activity of monocyclic model compounds containing spongistatin triene side-chains.
Two monosaccharides embodying triene side-chains of the spongistatins display significant in vitro activity against human cancer cell lines.
Smith
A B
AB
Department of Chemistry, University of Pennsylvania, Philadelphia 19104, USA.
Lin
Q
Q
Pettit
G R
GR
Chapuis
J C
JC
Schmidt
J M
JM
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002240:Carbohydrate Sequence; D002455:Cell Division / Q000187:drug effects; D004988:Ethers, Cyclic / Q000737:chemistry; D006801:Humans; D007783:Lactones / Q000737:chemistry; D018942:Macrolides; D008956:Models, Chemical; D008969:Molecular Sequence Data; D014407:Tumor Cells, Cultured / Q000187:drug effects; D000095702:Polyether Toxins
D000970:Antineoplastic Agents; D004988:Ethers, Cyclic; D007783:Lactones; D018942:Macrolides; C083856:spongistatin 1; D000095702:Polyether Toxins