High-throughput synthesis and direct screening for the discovery of novel hydrolytic metal complexes.
A 'combinatorial catalysis' strategy was utilized to both rapidly synthesized organometallic complexes and to screen them for catalytic activity in chemical reactions. The application of this strategy has yielded several metal-complexes that catalyze the hydrolysis of carboxylic acid esters efficiently.
Berg
T
T
Scripps Research Institute, Department of Chemistry, La Jolla, CA, USA.
Vandersteen
A M
AM
Janda
K D
KD
D002265:Carboxylic Ester Hydrolases; D002384:Catalysis; D007700:Kinetics; D008670:Metals; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000138:chemical synthesis
D008670:Metals; D009942:Organometallic Compounds; D002265:Carboxylic Ester Hydrolases