title: Estimating the persistence length of a worm-like chain molecule from force-extension measurements.
abstract: We describe a simple computation of the worm-like chain model and obtain the corresponding force-versus-extension curve. We propose an improvement to the Marko and Siggia interpolation formula of Bustamante et al (Science 1994, 265:1599-1600) that is useful for fitting experimental data. We apply it to the experimental elasticity curve of single DNA molecules. Finally, we present a tool to study the agreement between the worm-like chain model and experiments.
authors.affiliation: LPT, ENS, Laboratoire propre du CNRS, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Bouchiat
authors.forename: M D
authors.initials: MD
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Allemand
authors.forename: T
authors.initials: T
authors.lastname: Strick
authors.forename: S M
authors.initials: SM
authors.lastname: Block
authors.forename: V
authors.initials: V
authors.lastname: Croquette
mesh_terms: D055592:Biophysical Phenomena; D001703:Biophysics; D003198:Computer Simulation; D004247:DNA / Q000737:chemistry*; D004548:Elasticity; D008956:Models, Chemical; D009690:Nucleic Acid Conformation; D013816:Thermodynamics
chemical_list: D004247:DNA