title: Isolation and unambiguous synthesis of cryptolepinone: An oxidation artifact of cryptolepine
abstract: Cryptolepinone (3) was isolated as an artifact of extraction from Cryptolepis sanguinolenta. Previously, this compound had been identified as the natural products hydroxycryptolepine (2) and 3. Synthesis via an unambiguous pathway has confirmed the structure of cryptolepinone. Spectroscopic studies in various solvents have shown that the natural product artifact or its synthetic equivalent can exist in the keto (cryptolepinone) or enol (hydroxycryptolepine) form.
authors.affiliation: Shaman Pharmaceuticals, 213 East Grand Avenue, South San Francisco, California 94080-4812, USA.
authors.initials: DM
authors.lastname: Fort
authors.initials: J
authors.lastname: Litvak
authors.initials: JL
authors.lastname: Chen
authors.initials: Q
authors.lastname: Lu
authors.initials: PW
authors.lastname: Phuan
authors.initials: R
authors.lastname: Cooper
authors.initials: DE
authors.lastname: Bierer