title: 99m-Technetium sestamibi localized solitary parathyroid adenoma as an indication for limited unilateral surgical exploration.
abstract: BACKGROUND
  Because of its successful localization of solitary adenomas, 99m-Technetium sestamibi (MIBI) may challenge the standard operation for primary hyperparathyroidism.
  
  
  METHODS
  Thirty-five consecutive patients underwent preoperative MIBI localization to optimize a surgical approach. Single-site localization in 21 patients directed a limited unilateral neck exploration (UNE) with adenomectomy and ipsilateral gland biopsy. Fourteen patients who did not localize underwent bilateral neck exploration (BNE). Conversion to a bilateral operation was required in 1 UNE patient because no adenoma was found on that side.
  
  
  RESULTS
  There were no significant differences in preoperative and postoperative serological markers between the two groups. However, the total operative time for UNE (49 +/- 21 minutes) was significantly less than for BNE (103 +/- 45 minutes; P <0.001).
  
  
  CONCLUSIONS
  Preoperative MIBI scan-directed limited unilateral neck operation may be used reliably for primary hyperparathyroidism due to a single adenoma, and thereby reduce operative time, extent of surgical dissection, and risk.
authors.affiliation: Department of Surgery, Medical College of Georgia, Augusta, USA.
authors.forename: V K
authors.initials: VK
authors.lastname: Gupta
authors.forename: K A
authors.initials: KA
authors.lastname: Yeh
authors.forename: G J
authors.initials: GJ
authors.lastname: Burke
authors.forename: J P
authors.initials: JP
authors.lastname: Wei
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000209:etiology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures; D010282:Parathyroid Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*; D018579:Patient Selection; D011300:Preoperative Care; D016719:Radioimmunodetection; D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi; D013997:Time Factors
chemical_list: D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi