Design and synthesis of thiol-reactive lipopeptides.
Lipopeptides are potent adjuvants that trigger an immune response against covalently conjugated low molecular mass antigens. We report here the design and synthesis of thiol-reactive lipopeptides (6, 7) which can be incorporated into liposomes and react, under mild conditions, with synthetic peptides carrying a thiol function.
Boeckler
C
C
Laboratoire de Chimie Bioorganique, CNRS-UMR 7514, Université Louis Pasteur, Faculté de Pharmacie, Illkirch, France.
Frisch
B
B
Schuber
F
F
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis / Q000737:chemistry*; D015195:Drug Design; D008074:Lipoproteins / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*
D000276:Adjuvants, Immunologic; D008074:Lipoproteins; D010455:Peptides; D013438:Sulfhydryl Compounds