title: Clinical and haemodynamic correlates of heart rate variability in children with congenital heart disease.
abstract: Heart rate variability (HRV) represents a noninvasive parameter for studying the autonomic control of the heart. Cardiac patients have a complex autonomic disturbance. The relation of HRV to this abnormality in children with congenital heart disease (CHD) has not yet been examined. The present study examined HRV indices from 24 h Holter recordings in 258 children with an operated or non-operated CHD, to determine their differences as an indicator of the severity of heart disease. The latter was defined clinically as New York Heart Association (NYHA) functional classes I to IV and haemodynamically by invasive parameters. Five time-domain measures (SDNN, SDNNi, SDANNi, rMSSD and pNN50) and three frequency-domain measures (LF, HF and balance LF/HF) were compared with normal ranges. HRV was reduced in children with CHD, except in patients of NYHA class I. The level of reduction depended on the NYHA functional class. None of the measures was significantly related to haemodynamic data.
  
  
  CONCLUSIONS
  Heart rate variability is reduced in children with Congenital heart disease depending on the functional limitation but not on haemodynamic disturbances. Heart rate variability indices are sensitive markers of the clinical state.
authors.affiliation: Department of Paediatric Cardiology, Klinikum der R.W.T.H. Aachen, Germany. martial.massin@chrcitadelle.be
authors.forename: M
authors.initials: M
authors.lastname: Massin
authors.forename: G
authors.initials: G
authors.lastname: von Bernuth
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D015716:Electrocardiography, Ambulatory; D006330:Heart Defects, Congenital / Q000145:classification / Q000503:physiopathology* / Q000601:surgery; D006339:Heart Rate / Q000502:physiology*; D006439:Hemodynamics; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D012189:Retrospective Studies; D012815:Signal Processing, Computer-Assisted