title: Practical synthesis of Taxol side chain.
abstract: Practical large scale synthesis of N-benzoyl-(2R,3S)-phenylisoserine methyl ester of the Taxol side chain has been attained from the coupling of chiral imine of N-[(S)-methylbenzyl]benzaldimine with (Z)-alpha-methoxy trimethylsilyl ketene acetal followed by the sequential reactions of lactamization, demethylation, methanolysis and N-benzoylation.
authors.affiliation: Department of Chemistry, Hankuk University of Foreign Studies, Yongin, Kyunggi-Do, Korea. hjha@maincc.hufs.ac.kr
authors.forename: H J
authors.initials: HJ
authors.lastname: Ha
authors.forename: G S
authors.initials: GS
authors.lastname: Park
authors.forename: Y G
authors.initials: YG
authors.lastname: Ahn
authors.forename: G S
authors.initials: GS
authors.lastname: Lee
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000737:chemistry*; D017239:Paclitaxel / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel