A photoactivated prodrug.
A photolabile derivative (1) of the anticancer drug, 5-fluorodeoxyuridine (2), was designed and synthesized as a model prodrug. Photolysis of 1 with long-wavelength UV light rapidly released 2 in solution. While compound 1 alone is nontoxic to cells, the presence of both 1 and UV irradiation (lambda = 350 nm) resulted in potent inhibition of cell growth.
Wei
Y
Y
Department of Chemistry, Ohio State University, Columbus 43210, USA.
Yan
Y
Y
Pei
D
D
Gong
B
B
D000964:Antimetabolites, Antineoplastic / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004926:Escherichia coli; D005467:Floxuridine / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D008956:Models, Chemical; D010777:Photochemistry; D010782:Photolysis; D011355:Prodrugs / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D014466:Ultraviolet Rays
D000964:Antimetabolites, Antineoplastic; D011355:Prodrugs; D005467:Floxuridine