Analysis of serum antibody responses to periodontopathogens in early-onset periodontitis patients from different geographical locations.
Serum antibody specificity to oral micro-organisms was used to delineate the pathogens associated with early-onset periodontal diseases in a Turkish population. Additionally, comparison of the findings to those derived from a clinically similar US patient population described differences in bacterial specific antibody between these 2 geographic regions. Serum from 89 (LJP), 86 (RPP) and 94 (normal) subjects was analyzed (ELISA) to determine IgG antibody to 14 oral micro-organisms. All LJP patients from Turkey exhibited elevated antibody levels to A. actinomycetemcomitans (serotypes c and a significantly increased), while antibody levels to A. actinomycetemcomitans Y4 and JP2 (serotype b) were significantly higher in US LJP patients. 50% of the Turkish RPP patients also showed elevated anti-A. actinomycetemcomitans antibody, although the US RPP patients exhibited significantly higher antibody levels and frequency of elevated antibody to the A. actinomycetemcomitans serotypes. Healthy subjects and LJP and RPP patients from the US exhibited higher antibody levels to all 3 P. gingivalis serogroups compared to those from Turkey, although, the frequency of elevated antibody to the P. gingivalis serogroups was significantly higher in LJP and RPP patients from Turkey than from the US. Interestingly, 87% and 77% of the LJP patients in the Turkish population had elevated antibody responses to P. gingivalis and E. corrodens, respectively, which was not observed in the US LJP patients. These data suggested that considerable variation exists in the systemic antibody levels to periodontopathogens between these 2 countries. This supports potential differences in subgingival colonization or antigenic composition of these pathogens between patient populations from different geographical regions.
Celenligil
H
H
Department of Periodontology, Faculty of Dentistry, Hacettepe University, Ankara, Turkey.
Ebersole
J L
JL
D000293:Adolescent; D000328:Adult; D016976:Aggregatibacter actinomycetemcomitans / Q000276:immunology*; D010520:Aggressive Periodontitis / Q000097:blood / Q000453:epidemiology / Q000276:immunology* / Q000382:microbiology*; D000907:Antibodies, Bacterial / Q000097:blood; D000940:Antigenic Variation; D002167:Campylobacter / Q000276:immunology; D002206:Capnocytophaga / Q000276:immunology; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D016124:Eikenella corrodens / Q000276:immunology; D005260:Female; D016967:Fusobacterium nucleatum / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D017720:Molecular Epidemiology; D010518:Periodontitis / Q000097:blood / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology; D016966:Porphyromonas gingivalis / Q000276:immunology; D018713:Prevotella intermedia / Q000276:immunology; D012111:Residence Characteristics; D012703:Serotyping; D018709:Statistics, Nonparametric; D014421:Turkey / Q000453:epidemiology; D014481:United States / Q000453:epidemiology
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G