Product development studies on the tablet formulation of ibuprofen to improve bioavailability.
To improve the bioavailability of ibuprofen, a thorough preformulation trial was undertaken. As a part of these studies, particle size of the drug, solubility-pH profile, and pH-partition coefficient profile were studied. The probability of improving solubility by solid dispersion technique was also investigated. The effects of different binding agents and incorporation of various proportions of sodium lauryl sulfate on the release rate of ibuprofen were also studied. The in vitro release profiles of the developed tablets showed superiority over the popular marketed tablets.
Ghosh
L K
LK
Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
Ghosh
N C
NC
Chatterjee
M
M
Gupta
B K
BK
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007052:Ibuprofen / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D066298:In Vitro Techniques; D010316:Particle Size; D012967:Sodium Dodecyl Sulfate; D012995:Solubility; D013607:Tablets
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013607:Tablets; D012967:Sodium Dodecyl Sulfate; D007052:Ibuprofen