A new series of C3-aza carbocyclic influenza neuraminidase inhibitors: synthesis and inhibitory activity.
The synthesis and influenza neuraminidase inhibitory activity of a new series of C3-aza carbocyclic neuraminidase inhibitors are described. Analogues 3c and 3j, bearing a 3-pentyl group, exhibit influenza A inhibitory activities comparable to that of 1.
Lew
W
W
Gilead Sciences Inc., Foster City, CA 94404, USA.
Wu
H
H
Mendel
D B
DB
Escarpe
P A
PA
Chen
X
X
Laver
W G
WG
Graves
B J
BJ
Kim
C U
CU
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D009439:Neuraminidase / Q000037:antagonists & inhibitors* / Q000737:chemistry; D009975:Orthomyxoviridae / Q000187:drug effects* / Q000201:enzymology; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D001372:Aza Compounds; D004791:Enzyme Inhibitors; D009439:Neuraminidase