Growth inhibitory activities of kalopanaxsaponins A and I against human pathogenic fungi.
Antifungal activities of the compounds isolated from Kalopanax pictus against representative fungi of dermatomycosis were investigated using paper disc diffusion method. It was found that kalopanaxsaponins A and I were effective in inhibiting the growth of Candida albicans KCTC 1940 and Cryptococcus neoformans KCTC 7224 with minimum inhibitory concentration (MIC) of 25 micrograms/ml. It showed that antifungal activity of both compounds have strong selectivity against the fungi of dermatomycosis.
Kim
D W
DW
Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Japan.
Bang
K H
KH
Rhee
Y H
YH
Lee
K T
KT
Park
H J
HJ
D000935:Antifungal Agents / Q000494:pharmacology*; D003883:Arthrodermataceae / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D005658:Fungi / Q000187:drug effects* / Q000254:growth & development*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009828:Oleanolic Acid / Q000031:analogs & derivatives*; D012503:Saponins / Q000737:chemistry / Q000494:pharmacology*
D000935:Antifungal Agents; D012503:Saponins; C010177:beta-hederin; C117027:kalopanax saponin I; D009828:Oleanolic Acid