Liver function following pregnancy complicated by the HELLP syndrome.
Serum levels of aminotransferases, lactate dehydrogenase, gammaglutamyl transferase, alkaline phosphatase, albumin and conjugated bilirubin, measured in 54 women at a median of 31 months (range 3-101) after pregnancies complicated by the HELLP syndrome, were not elevated. Total bilirubin levels, however, were elevated in 20% of these women; this represents a significant difference from the prevalence in 151 women with a previous normal pregnancy (chi2 = 12.23, P < 0.001), or in the normal female population (chi2 = 22.34, P < 0.00001). This raises the possibility that a dysfunction of the bilirubin-conjugating mechanism represents a risk factor for the development of the HELLP syndrome.
Knapen
M F
MF
Department of Obstetrics and Gynaecology, University Hospital St Radboud, Nijmegen, The Netherlands.
van Altena
A M
AM
Peters
W H
WH
Merkus
H M
HM
Jansen
J B
JB
Steegers
E A
EA
D000328:Adult; D000410:Alanine Transaminase / Q000032:analysis; D000418:Albumins / Q000032:analysis; D000469:Alkaline Phosphatase / Q000032:analysis; D001219:Aspartate Aminotransferases / Q000032:analysis; D001663:Bilirubin / Q000032:analysis; D005260:Female; D017359:HELLP Syndrome / Q000150:complications*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D008107:Liver Diseases / Q000209:etiology*; D011247:Pregnancy; D005723:gamma-Glutamyltransferase / Q000032:analysis
D000418:Albumins; D007770:L-Lactate Dehydrogenase; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin