Functional MRI of the brain: localisation of eloquent cortex in focal brain lesion therapy.
The aim of this study was to assess the feasibility of functional MRI (fMRI) in a clinical environment on a large patient group, and to evaluate the pretherapeutic value of localisation of eloquent cortex. Forty patients with focal brain lesions of different origin were studied using fMRI. Functional information was obtained using motor, somatosensory, auditory and phonological stimuli depending on the localisation of the lesions. To obtain information about the spatial accuracy of fMRI, the results were compared with postoperative electrocortical stimulation. Two patients with secondary trigeminal neuralgia were scanned using a motor protocol and were implanted with an extradural plate electrode. Imaging was successful in 40 of 42 patients (including the 2 with trigeminal neuralgia). These patients were analysed for strength of activation, the relation of the lesion to activation sites and the presence of mass effect. The correlation between these data and surgical findings provided significant additional clinical information. Functional MRI can be accurately performed in patients with focal brain lesions using a dedicated approach. Functional MRI offers important clinical information as a contribution to a decrease in posttherapeutic morbidity. The accuracy of the technique can be confirmed by other modalities, including invasive cortical electrostimulation.
Dymarkowski
S
S
Department of Radiology, University Hospitals, Leuven, Belgium.
Sunaert
S
S
Van Oostende
S
S
Van Hecke
P
P
Wilms
G
G
Demaerel
P
P
Nuttin
B
B
Plets
C
C
Marchal
G
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D001303:Auditory Cortex / Q000502:physiology; D001927:Brain Diseases / Q000503:physiopathology / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D002540:Cerebral Cortex / Q000503:physiopathology*; D002648:Child; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000503:physiopathology; D010347:Patient Care Planning; D011182:Postoperative Care; D013003:Somatosensory Cortex / Q000503:physiopathology; D013060:Speech / Q000502:physiology; D014277:Trigeminal Neuralgia / Q000503:physiopathology