Novel hydrophilic cyclic monomers in hydrogel synthesis.
A range of hydrogels was prepared by the copolymerisation of 2-hydroxyethyl methacrylate (HEMA) with various hydrophilic cyclic monomers (CM) derived from cis-1,2-dihydroxy-3,5-cyclohexadiene (DHCD). The specific systems investigated were the cis-1,2-bis(2,3-epoxybutanoyloxy)-, cis-1,2-bis(10,11-epoxyundecanoyloxy)-, cis-1,2-bis(trimethylsiloxy)- and cis-1,2-bis(tert-butyldimethylsiloxy)-3,5-cyclohexadienes. The EWC, tensile strength and initial modulus of the poly HEMA-CM hydrogels derived from the epoxy compounds showed lower EWCs but similar mechanical properties compared with polyHEMA itself. Treatment of the hydrogel derived from cis-1,2-bis(2,3-epoxybutanoyloxy)-3,5-cyclohexadiene with 20% sodium hydroxide increased the EWC value markedly but produced highly fragile materials.
Jarvie
A W
AW
Department of Chemical Engineering and Applied Chemistry, Aston University, Aston Triangle, Birmingham, UK.
Lloyd
M C
MC
St Pourcain
C B
CB
D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry; D001696:Biomechanical Phenomena; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003510:Cyclohexanes / Q000737:chemistry*; D053138:Cyclohexenes; D020100:Hydrogels / Q000138:chemical synthesis* / Q000737:chemistry; D008689:Methacrylates / Q000138:chemical synthesis / Q000737:chemistry
D001672:Biocompatible Materials; D003510:Cyclohexanes; D053138:Cyclohexenes; D020100:Hydrogels; D008689:Methacrylates; C048401:1,4-cyclohexadiene; C005044:hydroxyethyl methacrylate