Functionalized 1,3-teraryls as a new class of hepatoprotectants. Part V.
Functionalized 1,3-teraryls, synthesized through ring transformation of 6-aryl-3-carbomethoxy-4-methylthio-2H-pyran-2-one from arylketone have been screened for their hepatoprotective activity and of them have demonstrated significant protection in animal model.
Ram
V J
VJ
Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow, India.
Goel
A
A
Patnaik
G K
GK
D000818:Animals; D008099:Liver / Q000187:drug effects*; D008107:Liver Diseases / Q000517:prevention & control*; D020011:Protective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D011753:Pyrones / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats
D020011:Protective Agents; D011753:Pyrones