Menorrhagia in von Willebrand disease successfully treated with single daily dose tranexamic acid.
Four cases of menorrhagia in von Willebrand disease were successfully treated with tranexamic acid given in a single daily dose of 4 g for the first 3-5 days of the menstrual cycle. The pathophysiology and pharmacokinetics are discussed. The apparent improved efficacy and acceptability of this new dosing regime have been highlighted.
Ong
Y L
YL
Department of Haematology, Royal Group of Hospitals Trust, Belfast, UK.
Hull
D R
DR
Mayne
E E
EE
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000933:Antifibrinolytic Agents / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008595:Menorrhagia / Q000188:drug therapy* / Q000209:etiology; D014148:Tranexamic Acid / Q000627:therapeutic use*; D016896:Treatment Outcome; D014842:von Willebrand Diseases / Q000150:complications*
D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid