Reaction of guanosine with glucose under oxidative conditions.
Incubation of glucose with guanosine under oxidative conditions at 37 degrees C or 70 degrees C leads to the formation of a main product, which can be detected by HPLC/DAD. The compound was isolated and identified as N2-carboxymethyl-guanosine (CMG). To confirm the structure, CMG was also synthesized from glyoxal and guanosine.
Seidel
W
W
Institut für Pharmazie und Lebensmittelchemie der Universität München, Germany.
Pischetsrieder
M
M
D002851:Chromatography, High Pressure Liquid; D005947:Glucose / Q000737:chemistry*; D006151:Guanosine / Q000031:analogs & derivatives* / Q000032:analysis / Q000138:chemical synthesis / Q000737:chemistry*; D010084:Oxidation-Reduction; D013056:Spectrophotometry, Ultraviolet
C116804:N(2)-carboxymethylguanosine; D006151:Guanosine; D005947:Glucose