Design of novel tripeptides with macrophage migration-enhancing activity.
A new approach to the generation of biologically active peptides from non-peptide lead was demonstrated. C,N-termini protected Phe-Phe-His derivatives possessing macrophage migration-enhancing activity were designed on the basis of the structure of imidazoline derivative 1, and these structure-activity relationships were also described.
Nunami
K
K
Medicinal Chemistry Research Laboratory, Discovery Research Laboratories, Tanabe Seiyaku Co., Ltd., Saitama, Japan.
Yamada
M
M
Shimizu
R
R
D002465:Cell Movement / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D015195:Drug Design; D008262:Macrophage Activation / Q000187:drug effects*; D009842:Oligopeptides / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D009842:Oligopeptides