title: Synthesis and cytotoxicity of acetyl-4H,9H-naphtho[2,3-b]thiophene-4,9-diones.
abstract: Several new acetyl-4H,9H-naphtho[2,3-b]thiophene-4,9-diones were synthesized and evaluated for in vitro cytotoxicity by NCI against seven cancer cell types. 2,7-Diacetyl naphtho[2,3-b]thiophene-4,9-dione (9) showed significant cytotoxicity against leukemia cells with log GI50 values of -7.61 against SR cells and -7.18 against MOLT-4 cells. 3-Acetyl-naphtho[2,3-b]thiophene-4,9-dione (6) also demonstrated potent cytotoxicity in the latter cell line with log GI50 < -8.
authors.affiliation: Graduate Institute of Pharmaceutical Chemistry, China Medical College, Taichung, Taiwan, Republic of China.
authors.forename: L J
authors.initials: LJ
authors.lastname: Huang
authors.forename: S C
authors.initials: SC
authors.lastname: Kuo
authors.forename: C Y
authors.initials: CY
authors.lastname: Perng
authors.forename: Y H
authors.initials: YH
authors.lastname: Chao
authors.forename: T S
authors.initials: TS
authors.lastname: Wu
authors.forename: A T
authors.initials: AT
authors.lastname: McPhail
authors.forename: A
authors.initials: A
authors.lastname: Mauger
authors.forename: H H
authors.initials: HH
authors.lastname: Cheng
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007624:KB Cells / Q000187:drug effects; D009284:Naphthols / Q000138:chemical synthesis* / Q000494:pharmacology*; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D009284:Naphthols; D013876:Thiophenes