title: Beneficial effect of risperidone on sleep disturbance and psychosis following traumatic brain injury.
abstract: Severe disturbances of sleep architecture and circadian rhythms are common in traumatic brain injured patients; however, complete absence of the rapid eye movement sleep stage is very rare. We describe a brain injured patient with cognitive disturbances who developed severe alterations of sleep architecture, accompanied by paranoid and jealousy delusions. Following several trials with conventional antipsychotics his psychotic state stabilized but he continued to complain of insomnia and daytime fatigue. When treated with risperidone 2 mg/day, both his sleep and the delusional thoughts improved markedly and his daytime alertness increased. Severe deterioration of his support system brought about discontinuation of treatment with re-emergence of all symptoms.
authors.affiliation: Department of Psychiatry C, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Schreiber
authors.forename: E
authors.initials: E
authors.lastname: Klag
authors.forename: Y
authors.initials: Y
authors.lastname: Gross
authors.forename: R H
authors.initials: RH
authors.lastname: Segman
authors.forename: C G
authors.initials: CG
authors.lastname: Pick
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001930:Brain Injuries / Q000150:complications* / Q000523:psychology; D002940:Circadian Rhythm; D006801:Humans; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology; D018967:Risperidone / Q000627:therapeutic use*; D012893:Sleep Wake Disorders / Q000188:drug therapy* / Q000209:etiology
chemical_list: D014150:Antipsychotic Agents; D018967:Risperidone