title: Immunosuppressant activity in human beta-casein fragment analogs.
abstract: Human beta-casein fragment (54-59) having the amino acid sequence Val-Glu-Pro-Ile-Pro-Tyr, has been shown potent immunostimulant activity. Several analogs of this hexapeptide have been synthesized with modification in the N-terminal region and tested for their immunomodulatory activity. Interestingly, two hexapeptides have shown significant immunosuppressant activity.
authors.affiliation: Division of Biopolymers, Central Drug Research Institute, Lucknow, India.
authors.forename: M
authors.initials: M
authors.lastname: Bhattacharya
authors.forename: A
authors.initials: A
authors.lastname: Puri
authors.forename: R
authors.initials: R
authors.lastname: Sahai
authors.forename: W
authors.initials: W
authors.lastname: Haq
authors.forename: L M
authors.initials: LM
authors.lastname: Tripathi
authors.forename: V M
authors.initials: VM
authors.lastname: Srivastava
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002364:Caseins / Q000737:chemistry*; D002478:Cells, Cultured; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D010446:Peptide Fragments / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D002364:Caseins; D007166:Immunosuppressive Agents; D010446:Peptide Fragments