[Pre- and post-operative changes in serum levels of glycocholic acid and 3,5,3'-triiodothyronine and their clinical significance in patients with cholelithiasis].
Pre- and post-operative changes of serum glycine-conjugated cholic acid (CG) and 3,5,3'-triiodothyronine (T3) levels were observed in twenty-two patients with cholelithiasis. The increase of the levels of serum CG varied with the patients; the highest levels were seen in patients with cirrhosis. After operation, the levels of serum CG and T3 were decreased significantly in patients without cirrhosis. There was positive correlation between serum CG and T3 (r = 0.4667, P < 0.01). It is indicated that the lowering of serum CG after operation may be related to the lowering of serum T3; the significant increase of serum CG level is useful to the diagnosis of liver cirrhosis, which is more sensitive than Type B ultrasonography or routine examination of liver function.
Hu
M
M
Department of Endocrinology and Metabolism, Second Affiliated Hospital, Hunan Medical University, Changsha.
Wu
H
H
Chao
C
C
Yang
L
L
Xiong
S
S
Zhuang
Z G
ZG
Huang
Y
Y
Cao
Y
Y
Li
Y
Y
D000328:Adult; D015415:Biomarkers; D002769:Cholelithiasis / Q000097:blood* / Q000150:complications / Q000601:surgery; D005260:Female; D006002:Glycodeoxycholic Acid / Q000097:blood*; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D014285:Triiodothyronine, Reverse / Q000097:blood*
D015415:Biomarkers; D006002:Glycodeoxycholic Acid; D014285:Triiodothyronine, Reverse