title: New phthalimide derivatives with potent analgesic activity: II.
abstract: Seven new phthalimide derivatives (9a-g) with 1,2,4-oxadiazol-5-yl methyl group attached to nitrogen have been synthesized from N-phthaloylglycine 6 and arylamidoximes 7a-g. All of these showed potent analgesic effect with acetic acid induced "writhing" test in mice. One of the better compounds (ID50 = 2.2 mg/Kg i.p.) has been found to be 9a which also demonstrates analgesic activity against inflammatory pain.
authors.affiliation: Departamento de Química Fundamental, Universidade Federal de Pernambuco, Recife, PE, Brazil.
authors.forename: R
authors.initials: R
authors.lastname: Antunes
authors.forename: H
authors.initials: H
authors.lastname: Batista
authors.forename: R M
authors.initials: RM
authors.lastname: Srivastava
authors.forename: G
authors.initials: G
authors.lastname: Thomas
authors.forename: C C
authors.initials: CC
authors.lastname: Araujo
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D010797:Phthalimides / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010797:Phthalimides