Actinomycin D, C2 and VII, inhibitors of Grb2-SHC interaction produced by Streptomyces.
Actinomycin D, C2 and VII, cyclic peptides, inhibited Grb2 SH2 domain association (IC50 5-7 microM) with a phosphotyrosine containing peptide derived from the Shc protein (pTyr317). Actinomycins are the first examples of nonphosphorylated natural ligands of SH2 domain.
Nam
J Y
JY
Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea.
Kim
H K
HK
Son
K H
KH
Kim
S U
SU
Kwon
B M
BM
Han
M Y
MY
Chung
Y J
YJ
Bok
S H
SH
D048868:Adaptor Proteins, Signal Transducing; D003609:Dactinomycin / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology*; D051380:GRB2 Adaptor Protein; D015394:Molecular Structure; D011506:Proteins / Q000037:antagonists & inhibitors*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000378:metabolism*
D048868:Adaptor Proteins, Signal Transducing; D051380:GRB2 Adaptor Protein; D011506:Proteins; C116800:actinomycin VII; D003609:Dactinomycin; C116801:actinomycin C2