Topoisomerase I inhibitors from the Streptomyces sp. strain KM86-9B isolated from a marine sponge.
The crude extract of Streptomyces sp. strain KM86-9B, isolated from a marine sponge, displayed significant inhibition on topoisomerase I activity. Investigation of the causative components by bioactivity-directed fractionation resulted in the isolation of a series of iso- and anteiso-fatty acids.
Lee
H K
HK
Microbiology Lab., Korea Ocean Research & Development Institute, Ansan, Korea.
Lee
D S
DS
Lim
J
J
Kim
J S
JS
Im
K S
KS
Jung
J H
JH
D000818:Animals; D005591:Chemical Fractionation; D005227:Fatty Acids / Q000302:isolation & purification / Q000494:pharmacology*; D011161:Porifera / Q000382:microbiology*; D013302:Streptomyces / Q000737:chemistry*; D059004:Topoisomerase I Inhibitors
D005227:Fatty Acids; D059004:Topoisomerase I Inhibitors