Signet-ring cell carcinoma of the ileum: report of a case and review of the Japanese literature.
We report herein the extremely unusual case of a 71-year-old woman with signet-ring cell carcinoma of the ileum. She originally presented with a 6-month history of intermittent nausea and abdominal distention, but initial examinations, including gastrointestinal fiberscopy, ultrasonography, and computed tomography (CT) scan, failed to reveal any cause of her symptoms. A barium-enema study performed 11 months after her initial visit demonstrated a narrow portion of the terminal ileum. An ileocecal resection was subsequently performed, and an epigastric subcutaneous tumor was simultaneously excised. The specimen contained a tumor with a stenotic lumen resembling a "lead pipe", an ulcerative portion, and mucosa with a granular appearance adjoining its proximal site. Many small aphthous lesions with IIa + IIc appearance were seen in the apparently normal mucosa. Histopathological examination confirmed a diagnosis of signet-ring cell carcinoma. The small aphthous lesions seemed to be metastases spread via the lymphatic vessels. Our review of the medical literature revealed three cases of signet-ring cell carcinoma of the jejunum; however, this is the first reported case of signet-ring cell carcinoma of the ileum.
Iizawa
H
H
Department of Surgery, Yamagata Prefectural Central Hospital, Japan.
Ikeda
E
E
Sato
T
T
Ohta
Y
Y
D000368:Aged; D018279:Carcinoma, Signet Ring Cell / Q000473:pathology*; D005260:Female; D006801:Humans; D007078:Ileal Neoplasms / Q000473:pathology*; D007564:Japan