[Observation of therapeutic effect by combined administration of Salvia miltiorrhiza, ligustrazine and Panax notoginseng on late hemorrhagic shock of rabbits].
OBJECTIVE
To explore the therapeutic mechanism of Salvia miltiorrhize, ligustrazine and Panax notoginseng in treating late hemorrhagic shock in rabbit.


METHODS
Rabbit hemorrhagic shock models (MPA 5.3 kPa) were set up according to Wiggers' method and administrated Salvia miltiorrhiza, ligustrazine, Panax notoginseng. The values of blood RBC superoxide dismutase (SOD) and blood lactate (BL), plasma malondialdehyde (MDA) and magnesium (Mg++) were continuously monitored before shock, 120 minutes after shock, 60 and 120 minutes after hydraulic dilatation.


RESULTS
(1) In 120 minutes after shock, the level of SOD decreased and the concentrations of MDA, BL, Mg++ were markedly increased, which indicated that the cell membrane damage caused by oxygen free radicals in rabbit hemorrhagic shock. (2) Salvia miltiorrhiza, Ligustrazine or Panax notoginseng could alleviate lipidperoxidation injury to tissue. Compared with the single drug administration groups, the effects of oxygen free radicals scavangers by combined administration with half dose of 2 drugs were better than the single drug with full dose alone and the side effects such as depression of blood pressure and heart rates would be alleviated.


CONCLUSIONS
Combined administration of Salvia miltiorrhiza, ligustrazine and Panax notoginseng would half the dosage, the blood pressure depression and heart rate reduction alleviated and better result obtained.
Wang
Z W
ZW
Department of Thoracic and Cardiovascular Surgery, First Affiliated Hospital, Hubei Medical University, Wuhan.
Gao
S Z
SZ
Cheng
B C
BC
D000818:Animals; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D016166:Free Radical Scavengers / Q000008:administration & dosage; D008297:Male; D005894:Panax / Q000627:therapeutic use*; D008517:Phytotherapy; D010936:Plant Extracts; D010946:Plants, Medicinal; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage; D011719:Pyrazines / Q000008:administration & dosage*; D011817:Rabbits; D011897:Random Allocation; D027561:Salvia miltiorrhiza; D012771:Shock, Hemorrhagic / Q000188:drug therapy*; D014665:Vasodilator Agents / Q000008:administration & dosage
D004365:Drugs, Chinese Herbal; D016166:Free Radical Scavengers; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; D011719:Pyrazines; D014665:Vasodilator Agents; C017953:tetramethylpyrazine