title: Biologically selective potassium channel openers having 1,1-diethylpropyl group.
abstract: To find out selective potassium channel openers (PCOs), we synthesized several 3,5-disubstituted phenylcyanoguanidine derivatives and investigated their structure-activity relationships (SAR). As a result, we discovered selective PCOs having 1,1-diethylpropyl group toward antihypertensive activity.
authors.affiliation: Pharmaceutical Research Laboratories, Kanebo Ltd., Osaka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yoshiizumi
authors.forename: N
authors.initials: N
authors.lastname: Seko
authors.forename: N
authors.initials: N
authors.lastname: Nishimura
authors.forename: S
authors.initials: S
authors.lastname: Ikeda
authors.forename: K
authors.initials: K
authors.lastname: Yoshino
authors.forename: H
authors.initials: H
authors.lastname: Kondo
authors.forename: K
authors.initials: K
authors.lastname: Tanizawa
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D019806:Cromakalim / Q000494:pharmacology; D004285:Dogs; D007422:Intestines / Q000187:drug effects; D020110:Pinacidil / Q000494:pharmacology; D015221:Potassium Channels / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014132:Trachea / Q000187:drug effects / Q000502:physiology; D001743:Urinary Bladder / Q000187:drug effects / Q000502:physiology
chemical_list: D000959:Antihypertensive Agents; D015221:Potassium Channels; D019806:Cromakalim; D020110:Pinacidil