[Effects of smoking on oxygen free radicals and fibrinolytic system].
The effects of smoking on SOD, MDA, t-PA, PAI-1 were studied in 20 healthy men (10 smokers and 10 nonsmokers).


RESULTS
SOD decreased and MDA increased significantly in smokers. After acute smoking, SOD decreased and MDA increased significantly in all the subjects, t-PA and PAI-1 activities were increased immediately after acute smoking. There was a significant positive relationship between increased t-PA and SOD, whereas a significant negative relationship exists between increased t-PA and MDA.


CONCLUSIONS
Smoking increases oxygen free radicals. The release of t-PA is decreased in smokers, that might be resulted from the increases of oxygen free radicals.
Wang
Q
Q
Department of Cardiac Medicine, Xiangya Hospital, Hunan Medical University, Changsha.
Zhou
H
H
Sun
M
M
Jia
Z
Z
D000328:Adult; D003327:Coronary Disease / Q000209:etiology; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D012907:Smoking / Q000009:adverse effects* / Q000097:blood*; D013482:Superoxide Dismutase / Q000097:blood*; D010959:Tissue Plasminogen Activator / Q000378:metabolism*
D017395:Plasminogen Activator Inhibitor 1; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D010959:Tissue Plasminogen Activator