Asymmetric membrane capsules for osmotic drug delivery. I. Development of a manufacturing process.
This paper describes a novel non-disintegrating polymeric capsule and a manual and a semi-automatic process developed for its manufacture. The capsule wall was made by a phase inversion process in which the membrane structure was precipitated on stainless steel mold pins by dipping the mold pins into a coating solution containing a polymer-solvent-nonsolvent system followed by dipping into a quench solution. The resulting asymmetric membrane wall was composed of a thin dense region supported on a thicker porous region. The asymmetric membrane capsules can be filled with a blend of the active agent and excipients for use in osmotically modulated controlled drug delivery applications.
Thombre
A G
AG
Pfizer, Inc., Eastern Point Road, Groton, CT 06340, USA.
Cardinal
J R
JR
DeNoto
A R
AR
Herbig
S M
SM
Smith
K L
KL
D002214:Capsules; D004339:Drug Compounding; D016503:Drug Delivery Systems; D008567:Membranes, Artificial; D008855:Microscopy, Electron, Scanning; D009994:Osmolar Concentration; D011108:Polymers; D016062:Porosity; D012997:Solvents
D002214:Capsules; D008567:Membranes, Artificial; D011108:Polymers; D012997:Solvents