In-111 labeled leukocyte scintigraphy in patients with suspected inflammation after failed antibiotic therapy.
In-111 labeled leukocyte scintigraphy (In-111 WBC scan) was performed in 16 patients with inflammation suspected on the basis of laboratory findings, symptoms, and diagnostic imaging, but who had failed antibiotic therapy. In-111 WBC scans revealed an abnormal focus of radiotracer activity (positive scans) in five of 16 patients. No correlation was found between the peripheral WBC count and accumulation of In-111 WBC. Inflammatory disease suspected on the basis of the CRP level should be considered when In-111 WBC scanning results in negative findings. Our results indicated that In-111 WBC scanning has low sensitivity after antibiotic therapy. Selection of patients on the basis of persistent elevation of CRP may be valuable.
Nasu
R
R
Department of Radiology, Kansai Medical University, Moriguchi, Japan.
Akagi
K
K
Murata
T
T
Uokawa
K
K
Isoda
H
H
Itagaki
Y
Y
Tanaka
Y
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D007223:Infant; D007249:Inflammation / Q000000981:diagnostic imaging* / Q000188:drug therapy; D007962:Leukocytes / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D017211:Treatment Failure
D000900:Anti-Bacterial Agents; D007205:Indium Radioisotopes