title: A diffuse T lymphocytic gastrointestinal mucosal infiltration associated with Sjögren's syndrome resulting in a watery diarrhea syndrome and responsive to immunosuppressive therapy.
abstract: We report the case of a 45-yr-old white man, investigated for chronic diarrhea, malabsorption and weight loss associated with sicca syndrome. Endoscopic and x-ray examinations showed normal macroscopic mucosa in gastrointestinal tract (GIT). Immunohistochemistry showed diffuse polyclonal T cell lymphocytes infiltrating either epithelium and lamina propria in GIT. There was no villous atrophy in the jejunum and ileum. Corticosteroids, azathioprine, and cyclosporine failed to improve symptoms. Monthly intravenous cyclophosphamide administered over 1 yr, stopped the diarrhea and weight loss. The patient is free of symptoms up to a 5-yr follow-up.
authors.affiliation: Department of Gastroenterology, Bichat Claude Bernard Hospital, Paris, France.
authors.forename: I
authors.initials: I
authors.lastname: Sobhani
authors.forename: N
authors.initials: N
authors.lastname: Brousse
authors.forename: C
authors.initials: C
authors.lastname: Vissuzaine
authors.forename: E
authors.initials: E
authors.lastname: Mcintyre
authors.forename: J P
authors.initials: JP
authors.lastname: Marmuse
authors.forename: M F
authors.initials: MF
authors.lastname: Kahn
authors.forename: F
authors.initials: F
authors.lastname: Potet
authors.forename: M
authors.initials: M
authors.lastname: Mignon
mesh_terms: D002465:Cell Movement / Q000502:physiology; D003967:Diarrhea / Q000209:etiology*; D005753:Gastric Mucosa / Q000473:pathology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007413:Intestinal Mucosa / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012859:Sjogren's Syndrome / Q000150:complications / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology; D013601:T-Lymphocytes / Q000473:pathology* / Q000502:physiology
chemical_list: D007166:Immunosuppressive Agents