Bone marrow necrosis in bone marrow transplantation: the role of MR imaging.
We describe an ALL patient who developed extensive bone marrow necrosis at the time of relapse 2 months after allogeneic bone marrow transplantation from an HLA-identical sibling. The excruciating and diffuse bone pain, fever and precipitous drop in peripheral blood counts were characteristic. This case illustrates the importance of repeat bone marrow biopsies for the diagnosis of disease relapse and the potential application of MR imaging in the assessment of patients with bone marrow necrosis.
Chim
C S
CS
University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong.
Ooi
C
C
Ma
S K
SK
Lam
C
C
D000328:Adult; D001706:Biopsy; D001772:Blood Cell Count; D001853:Bone Marrow / Q000473:pathology*; D001856:Bone Marrow Examination; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000473:pathology*; D002051:Burkitt Lymphoma / Q000628:therapy; D005334:Fever / Q000209:etiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009336:Necrosis; D010146:Pain / Q000209:etiology; D012008:Recurrence; D014184:Transplantation, Homologous