title: Serine derived NK1 antagonists. 2: A pharmacophore model for arylsulfonamide binding.
abstract: Modifications to the spirocyclic aryl sulfonamide portion of serine derived NK1 antagonists allow a partial pharmacophore model to be developed.
authors.affiliation: Merck Sharp and Dohme Research Laboratories, Neuroscience Research Center, Harlow, Essex, U.K.
authors.forename: J M
authors.initials: JM
authors.lastname: Elliott
authors.forename: H
authors.initials: H
authors.lastname: Broughton
authors.forename: M A
authors.initials: MA
authors.lastname: Cascieri
authors.forename: G
authors.initials: G
authors.lastname: Chicchi
authors.forename: I T
authors.initials: IT
authors.lastname: Huscroft
authors.forename: M
authors.initials: M
authors.lastname: Kurtz
authors.forename: A M
authors.initials: AM
authors.lastname: MacLeod
authors.forename: S
authors.initials: S
authors.lastname: Sadowski
authors.forename: G I
authors.initials: GI
authors.lastname: Stevenson
mesh_terms: D008956:Models, Chemical; D064729:Neurokinin-1 Receptor Antagonists; D010880:Piperidines / Q000737:chemistry* / Q000494:pharmacology; D018040:Receptors, Neurokinin-1 / Q000378:metabolism; D012694:Serine / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000378:metabolism*
chemical_list: D064729:Neurokinin-1 Receptor Antagonists; D010880:Piperidines; D018040:Receptors, Neurokinin-1; D013449:Sulfonamides; D012694:Serine