Synthesis and morphological reversion activity on srctsNRK cells of pyrimidinylpropanamide antibiotics, sparsomycin, sparoxomycin A1, A2, and their analogues.
Three pyrimidinylpropanamide antibiotics sparsomycin (1), sparoxomycins A1, A2 (2, 3), and also six analogues (4-9) have been synthesized by employing asymmetric sulfide oxidation conditions as a key step. Sparsomycin (1) and its alkyl analogues (5-7) showed higher morphological reversion activities on srctsNRK cells than 2 and 3.
Nakajima
N
N
Biotechnology Research Center, Toyama Prefectural University, Japan.
Enomoto
T
T
Matsuura
N
N
Ubukata
M
M
D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis* / Q000494:pharmacology; D001358:Avian Sarcoma Viruses; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D011744:Pyrimidinones / Q000138:chemical synthesis / Q000494:pharmacology; D013033:Sparsomycin / Q000138:chemical synthesis* / Q000494:pharmacology
D000903:Antibiotics, Antineoplastic; D011744:Pyrimidinones; C098364:sparoxomycin A1; D013033:Sparsomycin