C24 and C25 substituted marcfortine A derivatives.
The dioxepinoindole ring found in marcfortine A (1) is unique among natural products. In order to determine the importance of the substitution pattern of the C24-C25 olefin, we synthesized a variety of analogs at these positions. With the exception of compound 5, none of these compounds exhibited any anthelmintic activity.
Lee
B H
BH
Animal Health Discovery Research, Pharmacia & Upjohn, Inc., Kalamazoo, MI 49001, USA.
Clothier
M F
MF
D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis* / Q000494:pharmacology; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D006189:Haemonchus / Q000187:drug effects; D007212:Indolizines; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000871:Anthelmintics; D001643:Bridged Bicyclo Compounds; D007212:Indolizines; D013141:Spiro Compounds; C103037:marcfortine A