title: [Characterization of the adaptive response to the action of gamma-rays, induced by low doses of 14C in Chinese hamster fibroblasts].
abstract: It has been studied the correlation of the mitotic activity of the chromosome aberrations and apoptosis, in the V-79 cells pre-exposure to an adapting dose of ionizing radiation from 14C-thymidine prior to an acute challenge dose of gamma-rays. In spite of that the incubation of the cells with isotope increased of the yield of the chromosome aberrations, but the cells became more resistant to following gamma-irradiation. Increasing the adaptive dose of the 14C on degree didn't influence on the present of the adaptive response. However, using concentrations of the 14C damaged metaphase/anaphase transition and cells blocked in this check-point by apoptotic death. The results suggest, that the cellular selection has been involved in 14C-induced adaptive response, estimated by level of asymmetric chromosome aberrations in V-79 cells.
authors.affiliation: Petersburg Nuclear Physics Institute, Russian Academy of Science, Gatchina.
authors.forename: N Ia
authors.initials: NIa
authors.lastname: Gilliano
authors.forename: O I
authors.initials: OI
authors.lastname: Bol'shakova
authors.forename: G A
authors.initials: GA
authors.lastname: Lavrova
authors.forename: L V
authors.initials: LV
authors.lastname: Konevega
authors.forename: E G
authors.initials: EG
authors.lastname: Bikineeva
authors.forename: L A
authors.initials: LA
authors.lastname: Noskin
mesh_terms: D000222:Adaptation, Physiological / Q000528:radiation effects*; D000705:Anaphase / Q000528:radiation effects; D000818:Animals; D002250:Carbon Radioisotopes; D002460:Cell Line; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus; D005347:Fibroblasts / Q000528:radiation effects*; D005720:Gamma Rays; D008677:Metaphase / Q000528:radiation effects; D008938:Mitosis / Q000528:radiation effects
chemical_list: D002250:Carbon Radioisotopes
vernacular_title: Kharakteristika adaptivnogo otveta k deĭstviiu gamma-lucheĭ, indutsirovannogo malymi dozami 14C v fibroblastakh kitaĭskogo khomiachka.