[Pseudo-Glanzmann thrombasthenia in the course of autoimmune thrombocytopenic purpura].
BACKGROUND
Auto-immune thrombocytopenic purpura is associated with platelet anti-glycoprotein antibodies, particularly with anti-GPIIb/IIIa complex. Persistence of these antibodies sometimes leads to acquired auto-immune thrombopathy.


METHODS
We report the case of a woman treated by splenectomy for auto-immune thrombocytopenic purpura, who developed 5 years later an ecchymotic syndrome despite normal platelet count. High bleeding time and platelet aggregation defect in vitro were evidenced. Following the initial thrombocytopenia, anti-glycoproteins GPIIb/IIIa with lupus anticoagulant and benign monoclonal gammapathy were noticed. Platelet controls showed that hypoaggregant activity was secondary to the persistence of anti-GPIIb/IIa antibodies.


CONCLUSIONS
This acquired auto-immune thrombopathy simulating Glanzmann's thrombasthenia was secondary to the persistence of platelet anti-glycoproteins GPIIb/IIIa.
Granel
B
B
Service de médecine interne, CHU de la Timone, Marseille, France.
Swiader
L
L
Veit
V
V
Rey
J
J
Reviron
D
D
Disdier
P
P
Harlé
J R
JR
Weiller
P J
PJ
D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D001760:Bleeding Time; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000097:blood; D010265:Paraproteinemias / Q000097:blood / Q000175:diagnosis* / Q000276:immunology; D010974:Platelet Aggregation; D010976:Platelet Count; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000276:immunology; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000601:surgery*; D013156:Splenectomy; D013915:Thrombasthenia / Q000097:blood / Q000175:diagnosis* / Q000276:immunology; D013997:Time Factors
D001323:Autoantibodies; D016682:Lupus Coagulation Inhibitor; D019039:Platelet Glycoprotein GPIIb-IIIa Complex
Pseudo-maladie de Glanzmann au décours d'un purpura thrombopénique auto-immun.