Vibrational circular dichroism: an incisive tool for stereochemical applications.
Vibrational circular dichroism (VCD) is the extension of circular dichroism (CD) from electronic to vibrational transitions in molecules. In this review, we present the basic concepts of VCD and focus on its growing strength for stereochemical applications. There are three principal areas of application of VCD. These are the determination of optical purity, the determination of absolute configuration and the determination of conformational properties of chiral molecules in solution. Until recently, the application of VCD was restricted to the use of instruments that had been custom assembled in academic research laboratories. This situation has now changed. It is possible to purchase a dedicated Fourier transform infrared (FTIR) VCD spectrometer complete with user friendly software. Combined with rapid advances in the ab initio theoretical prediction of infrared (IR) and VCD spectra, the availability of such technology opens the way for the widespread use of VCD spectroscopy for research and industrial applications.
Nafie
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LA
Department of Chemistry, Syracuse University, NY 13244-4100, USA. LNAFIE@SYR.EDU
Freedman
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TB
D002164:Camphor / Q000737:chemistry; D002942:Circular Dichroism; D003512:Cyclohexanones / Q000737:chemistry; D007773:Lactates / Q000737:chemistry; D008968:Molecular Conformation; D011433:Propranolol / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods*; D013237:Stereoisomerism
D003512:Cyclohexanones; D007773:Lactates; C028444:methyl lactate; D002164:Camphor; D011433:Propranolol