Experimental evaluation of second-line oral treatments of visceral leishmaniasis caused by Leishmania infantum.
In a murine model of Leishmania infantum visceral leishmaniasis, metronidazole, ketoconazole, fluconazole, itraconazole, and terbinafine were less effective than antimonial agents in reducing hepatic parasite load. Ketoconazole potentiated the effect of meglumine antimoniate reference therapy through its marked activity against spleen infection.
Gangneux
J P
JP
Laboratoire de Parasitologie-Mycologie, Faculté de Médecine Lariboisière-Saint-Louis, Paris, France. jpgangneux@chu-stlouis.fr
Dullin
M
M
Sulahian
A
A
Garin
Y J
YJ
Derouin
F
F
D000818:Animals; D004357:Drug Synergism; D005260:Female; D018314:Leishmania infantum; D007898:Leishmaniasis, Visceral / Q000188:drug therapy* / Q000469:parasitology; D008099:Liver / Q000469:parasitology; D008536:Meglumine / Q000627:therapeutic use; D000077485:Meglumine Antimoniate; D051379:Mice; D008807:Mice, Inbred BALB C; D009942:Organometallic Compounds / Q000627:therapeutic use; D013154:Spleen / Q000469:parasitology; D014344:Trypanocidal Agents / Q000627:therapeutic use*
D009942:Organometallic Compounds; D014344:Trypanocidal Agents; D008536:Meglumine; D000077485:Meglumine Antimoniate