Spontaneous murine lung adenocarcinoma (P07): A new experimental model to study paraneoplastic syndromes of lung cancer.
We report the histological and biological behavior characteristics of a lung tumor (P07) that arose spontaneously in a Balb/c mouse. P07 is a moderately to poorly differentiated adenocarcinoma that secretes granulocyte-macrophage colony stimulating factor (GM-CSF) in culture supernatants. This tumor presents some paraneoplastic syndromes, such as leukocytosis, hypercalcemia and cachexia. taken together with the peripheral blood leukocyte (PBL) counts and serum calcium levels during s.c. tumor growth and after surgery, this study suggests that P07 may be a useful experimental model to study the biology of lung cancer and paraneoplastic syndromes.
Diament
M J
MJ
Animal Care and Experimental Cancer Division, 1417 Buenos Aires, Argentina.
Garcìa
C
C
Stillitani
I
I
Saavedra
V M
VM
Manzur
T
T
Vauthay
L
L
Klein
S
S
D000230:Adenocarcinoma / Q000473:pathology / Q000503:physiopathology*; D000818:Animals; D001772:Blood Cell Count; D001835:Body Weight; D001853:Bone Marrow / Q000502:physiology; D002118:Calcium / Q000097:blood; D004195:Disease Models, Animal; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000378:metabolism; D006934:Hypercalcemia / Q000209:etiology; D007964:Leukocytosis / Q000209:etiology; D008175:Lung Neoplasms / Q000473:pathology / Q000503:physiopathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010257:Paraneoplastic Syndromes / Q000473:pathology / Q000503:physiopathology*
D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D002118:Calcium