title: ON-pathway dysfunction in a patient with acquired unilateral night blindness.
abstract: OBJECTIVE
  To investigate possible functional correlates of an apparent ON-pathway defect observed in the cone electroretinogram of a patient with acquired unilateral night blindness.
  
  
  METHODS
  Visual evoked potentials were recorded to the onset of a grid pattern consisting of either incremental or decremental squares. Saccadic eye movements were measured to luminance increments and decrements presented 5 degrees from fixation. The patient's results were compared with normative data.
  
  
  RESULTS
  Visual evoked potential latencies were prolonged to incremental stimulation of the patient's affected left eye but were within normal limits for the other three conditions (increments and decrements, right eye; decrements, left eye). A similar pattern of asymmetry between latencies to incremental and decremental stimulation of the affected eye was observed for saccadic eye movements.
  
  
  CONCLUSIONS
  The observed predominant delay in response to luminance increments supports the hypothesis of an ON-pathway dysfunction in this patient with acquired unilateral night blindness.
authors.affiliation: Department of Neurology, and the Neuroscience and Aging Institute, Loyola University Chicago, Maywood, Illinois 60153, USA.
authors.forename: C S
authors.initials: CS
authors.lastname: Barnes
authors.forename: M G
authors.initials: MG
authors.lastname: Brigell
authors.forename: K R
authors.initials: KR
authors.lastname: Alexander
mesh_terms: D000328:Adult; D004596:Electroretinography; D005074:Evoked Potentials, Visual; D006801:Humans; D008297:Male; D008875:Middle Aged; D009755:Night Blindness / Q000150:complications* / Q000503:physiopathology; D010775:Photic Stimulation; D017949:Retinal Cone Photoreceptor Cells / Q000503:physiopathology*; D012438:Saccades / Q000502:physiology; D014792:Visual Acuity; D014795:Visual Pathways / Q000503:physiopathology*