General ageing and ovarian ageing.
The age related decrease in female fertility is associated with a decrease in follicle numbers and oocyte quality. Meiotic division errors, mitochondrial DNA mutations and ageing itself have been suggested to play a part in the age associated reduction in oocyte quality. During the past decades several hypothesis have been proposed, trying to explain the underlying mechanisms. However, none of them is yet conclusive. This review will consider the main hypotheses regarding the age related reduction in oocyte quality. This will be reviewed together with recent results of studies analysing a possible relationship between ageing and ovarian ageing. On the basis of our own results and those presented in the literature, it is concluded that ovarian ageing may only be related to specific aspects of general ageing.
Dorland
M
M
Department of Reproductive Medicine, University Hospital Utrecht, The Netherlands. mdorland@dog.azu.nl
van Kooij
R J
RJ
te Velde
E R
ER
D000375:Aging / Q000502:physiology*; D002869:Chromosome Aberrations / Q000209:etiology; D025063:Chromosome Disorders; D005260:Female; D005298:Fertility / Q000502:physiology*; D006801:Humans; D008928:Mitochondria / Q000502:physiology; D009865:Oocytes / Q000502:physiology*; D010053:Ovary / Q000502:physiology*; D016615:Telomere / Q000502:physiology