title: A photoactivated prodrug.
abstract: A photolabile derivative (1) of the anticancer drug, 5-fluorodeoxyuridine (2), was designed and synthesized as a model prodrug. Photolysis of 1 with long-wavelength UV light rapidly released 2 in solution. While compound 1 alone is nontoxic to cells, the presence of both 1 and UV irradiation (lambda = 350 nm) resulted in potent inhibition of cell growth.
authors.affiliation: Department of Chemistry, Ohio State University, Columbus 43210, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Wei
authors.forename: Y
authors.initials: Y
authors.lastname: Yan
authors.forename: D
authors.initials: D
authors.lastname: Pei
authors.forename: B
authors.initials: B
authors.lastname: Gong
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004926:Escherichia coli; D005467:Floxuridine / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D008956:Models, Chemical; D010777:Photochemistry; D010782:Photolysis; D011355:Prodrugs / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D014466:Ultraviolet Rays
chemical_list: D000964:Antimetabolites, Antineoplastic; D011355:Prodrugs; D005467:Floxuridine