title: Carbaxylosides of 4-ethyl-2-oxo-2H-benzopyran-7-yl as non-hydrolyzable, orally active venous antithrombotic agents.
abstract: A (-)-conduritol F derivative was condensed with 4-ethyl-7-hydroxy-2H-1-benzopyran-2-one and converted into (+)-4-ethyl-7-[(1'R,2'S,3'S,4'R)-2',3',4'- trihydroxycyclohexyloxy]-2H-1-benzopyran-2-one ((+)-2). Enantiomer (-)-2 was obtained from a (+)-conduritol F derivative. The carbaxyloside (-)-2 with the L-xylose configuration was more active than (+)-2 in the Wessler's model.
authors.affiliation: Institut de chimie organique de l'Université de Lausanne, BCH, Lausanne-Dorigny, Switzerland.
authors.forename: V
authors.initials: V
authors.lastname: Jeanneret
authors.forename: P
authors.initials: P
authors.lastname: Vogel
authors.forename: P
authors.initials: P
authors.lastname: Renaut
authors.forename: J
authors.initials: J
authors.lastname: Millet
authors.forename: J
authors.initials: J
authors.lastname: Theveniaux
authors.forename: V
authors.initials: V
authors.lastname: Barberousse
mesh_terms: D000284:Administration, Oral; D000925:Anticoagulants / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001578:Benzopyrans / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D006868:Hydrolysis; D013927:Thrombosis / Q000188:drug therapy*; D014680:Veins / Q000473:pathology
chemical_list: D000925:Anticoagulants; D001578:Benzopyrans