title: Potential of autologous immunologic effector cells for prediction of progression of disease in patients with chronic myelogenous leukemia.
abstract: In autologous bone marrow transplantation, immunologic effector cells such as lymphokine activated killer (LAK) cells may be useful for purging of bone marrow since these cells might have an additional in vivo effect on tumor cells in contrast to other purging protocols. Recently, immunologic effector cells termed cytokine-induced killer (CIK) cells have been shown to be more useful than LAK cells for purging of autologous BM in the context of autologous BMT. Here, we show that the expression of bcr/abl in CIK cells generated from patients with CML correlates with progression of disease in individual patients. In addition, progression of disease from chronic phase to accelerated phase could be predicted in two patients by studying the expression of bcr/abl in CIK cells generated from CML patients. Thus, it might be possible to use CIK cell generation for the prediction of progression of disease in CML patients.
authors.affiliation: Abteilung Innere Medizin, Humboldt-Universität Berlin, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Müller
authors.forename: C
authors.initials: C
authors.lastname: Scheffold
authors.forename: P
authors.initials: P
authors.lastname: Lefterova
authors.forename: D
authors.initials: D
authors.lastname: Huhn
authors.forename: A
authors.initials: A
authors.lastname: Neubauer
authors.forename: I G
authors.initials: IG
authors.lastname: Schmidt-Wolf
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001854:Bone Marrow Cells / Q000276:immunology* / Q000473:pathology; D016465:Bone Marrow Purging; D016026:Bone Marrow Transplantation; D016207:Cytokines; D003602:Cytotoxicity, Immunologic; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000096:biosynthesis / Q000276:immunology; D006801:Humans; D020014:K562 Cells; D007694:Killer Cells, Natural / Q000276:immunology*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000276:immunology* / Q000473:pathology*; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D014182:Transplantation, Autologous
chemical_list: D016207:Cytokines; D016044:Fusion Proteins, bcr-abl