[New approaches in correcting disorders of higher integrative brain functions in the pharmacotherapy of arterial hypertension with propranolol].
In experiments on rats it is found that propranolol in a dose of 2 mg/kg has a negative effect on higher integrative functions of the brain. Nootropics--pyracetam (200 mg/kg), AKF-94 (20 mg/kg), PIR-87-6-O (50 mg/kg) and actoprotector bemityl (40 mg/kg)--normalized orientative-trying behavior, memory, and emotionality of the animals. A possible mechanism of the drug action and prospects of their clinical application are discussed.
Petrov
V I
VI
Research Institute of Pharmacology, Volgograd Medical Academy, Russian Federation Ministry of Public Health, Russia.
Solomin
M Iu
MIu
Gorbunov
S G
SG
D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects*; D003214:Conditioning, Classical / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D006613:Higher Nervous Activity / Q000187:drug effects*; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D018697:Nootropic Agents / Q000627:therapeutic use; D011433:Propranolol / Q000627:therapeutic use*; D051381:Rats
D000959:Antihypertensive Agents; D018697:Nootropic Agents; D011433:Propranolol
Novye podkhody k korrektsii narusheniĭ vysshikh integrativnykh funktsiĭ mozga pri farmakoterapii arterial'noĭ gipertenzii propranololom.