[The immunological effects of perftoran].
The effect of perftocarbonic emulsion-perftoran on the course of experimental lipopolysaccharide intoxication was studied in albino mice. Resistance of the animals to the endotoxin reduced 3 days after administration of 10 ml/kg of the preparation and increased 6 days after its administration. The effect of perftoran on the dynamics of some parameters of immunity and nonspecific resistance in CBA mice and guinea pigs was studied in immunodeficiency states induced by injection of 5-fluorouracil, cyclophosphamide, and irradiation. Activation of the phagocytic system occurred 3 days later, and activation of the parameters of cellular and humoral immunity 6 days later.
Pluzhnikov
N N
NN
Department of Infectious Diseases, St. Petersburg Military Medical Academy, Russia.
Lobzin
Iu V
IuV
Kovelenov
A Iu
AIu
Zhelezkova
E V
EV
Gusev
D A
DA
D000276:Adjuvants, Immunologic / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001802:Blood Substitutes / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004655:Emulsions; D005466:Fluorocarbons / Q000494:pharmacology / Q000627:therapeutic use*; D006168:Guinea Pigs; D007111:Immunity, Cellular / Q000187:drug effects; D007153:Immunologic Deficiency Syndromes / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA; D013997:Time Factors; D014916:Whole-Body Irradiation
D000276:Adjuvants, Immunologic; D001802:Blood Substitutes; D004655:Emulsions; D005466:Fluorocarbons; C063334:perftoran
Immunologichesie éffekty perftorana.