Polymer supported bases in solution-phase synthesis. 2. A convenient method for N-alkylation reactions of weakly acidic heterocycles.
A convenient solution-phase method for N-alkylation reactions of weakly acidic heterocycles employing polymer supported super base PBEMP is described. By using this method, multiple-step and chemoselective N-alkylation sequences can be carried out in a one-pot process.
Xu
W
W
Pharmaceuticals Discovery, Berlex Biosciences, Richmond, CA 94804, USA.
Mohan
R
R
Morrissey
M M
MM
D000478:Alkylation; D002625:Chemistry, Organic / Q000379:methods; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D006573:Heterocyclic Compounds, 1-Ring; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D008958:Models, Molecular; D015394:Molecular Structure; D009943:Organophosphorus Compounds; D011108:Polymers
D006571:Heterocyclic Compounds; D006573:Heterocyclic Compounds, 1-Ring; D007202:Indicators and Reagents; D009943:Organophosphorus Compounds; D011108:Polymers; C116638:BEMP phosphazene