title: Novel angucycline compound with both antigastrin- and gastric mucosal protective-activities.
abstract: An angucycline series compound P371 A1 (1) from Streptomyces sp. P371 was established to have a novel structure comprising an ureido group at one of four sugar units on the basis of 2D NMR techniques. 1 exhibited an inhibitory activity against the pentagastrin-stimulated acid secretion as well as protective activities against HCl/ethanol- and indomethacin-induced gastric lesions.
authors.affiliation: Department of Biotechnology, Faculty of Engineering, Kansai University, Osaka, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Uesato
authors.forename: T
authors.initials: T
authors.lastname: Tokunaga
authors.forename: K
authors.initials: K
authors.lastname: Takeuchi
mesh_terms: D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects*; D005755:Gastrins / Q000037:antagonists & inhibitors*; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D051381:Rats; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013329:Structure-Activity Relationship
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D005755:Gastrins; D006635:Histamine H2 Antagonists; C116795:P371 A1