Regulation of integrin-mediated adhesion during cell migration.
Migrating cells form dynamic and highly regulated adhesive interactions with their environment. In particular, integrin-mediated adhesions to the extracellular matrix (ECM) play a central role in cell migration. This review focuses on recent advances in understanding the adhesive mechanisms that regulate cell detachment at the rear of migrating fibroblasts and neutrophils. The contribution of several key adhesive regulators is discussed, including myosin mediated cell contractility, tyrosine phosphorylation, rho, calcium fluxes, and calpain. A challenge for future investigation will be to determine how adhesive events are spatially and temporally coordinated to promote productive directional cell movements.
Cox
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EA
Department of Cell and Structural Biology, University of Illinois at Urbana-Champaign, Urbana 61801, USA. ea-cox@pop.life.uiuc.edu
Huttenlocher
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A
D002118:Calcium / Q000378:metabolism; D002154:Calpain / Q000378:metabolism; D002448:Cell Adhesion / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D005109:Extracellular Matrix / Q000502:physiology*; D005347:Fibroblasts / Q000502:physiology; D016023:Integrins / Q000378:metabolism*; D009504:Neutrophils / Q000502:physiology; D010766:Phosphorylation; D014443:Tyrosine / Q000378:metabolism
D016023:Integrins; D014443:Tyrosine; D002154:Calpain; D002118:Calcium