Inhibition of thermolysin with nitrone-bearing substrate analogs: a new type of thermolysin inhibitors.
Nitrones are utilized as the active site zinc coordinating functionality in the design of inhibitors for thermolysin. This new type of thermolysin inhibitors are as potent as the existing inhibitors bearing a carboxylate or hydroxamate zinc ligating moiety.
Lee
K J
KJ
Department of Chemistry, Pohang University of Science and Technology, Korea.
Kim
D H
DH
D009589:Nitrogen Oxides / Q000737:chemistry*; D011480:Protease Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013820:Thermolysin / Q000037:antagonists & inhibitors*
D009589:Nitrogen Oxides; D011480:Protease Inhibitors; C015388:nitrones; D013820:Thermolysin