title: A new series of C3-aza carbocyclic influenza neuraminidase inhibitors: synthesis and inhibitory activity.
abstract: The synthesis and influenza neuraminidase inhibitory activity of a new series of C3-aza carbocyclic neuraminidase inhibitors are described. Analogues 3c and 3j, bearing a 3-pentyl group, exhibit influenza A inhibitory activities comparable to that of 1.
authors.affiliation: Gilead Sciences Inc., Foster City, CA 94404, USA.
authors.forename: W
authors.initials: W
authors.lastname: Lew
authors.forename: H
authors.initials: H
authors.lastname: Wu
authors.forename: D B
authors.initials: DB
authors.lastname: Mendel
authors.forename: P A
authors.initials: PA
authors.lastname: Escarpe
authors.forename: X
authors.initials: X
authors.lastname: Chen
authors.forename: W G
authors.initials: WG
authors.lastname: Laver
authors.forename: B J
authors.initials: BJ
authors.lastname: Graves
authors.forename: C U
authors.initials: CU
authors.lastname: Kim
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D009439:Neuraminidase / Q000037:antagonists & inhibitors* / Q000737:chemistry; D009975:Orthomyxoviridae / Q000187:drug effects* / Q000201:enzymology; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D001372:Aza Compounds; D004791:Enzyme Inhibitors; D009439:Neuraminidase