title: Amicrobial pustulosis of the folds. A cutaneous manifestation associated with connective tissue disease.
abstract: Amicrobial pustulosis (AP) is a recently defined entity associated with connective tissue diseases. Few cases have appeared in the literature. We report a case of AP coexisting with a systemic lupus erythematosus-scleroderma overlap syndrome and marked photosensitivity. The patient presented prominent pustular skin lesions and a few discoid lupus ones. No significant differences in the inflammatory infiltrate were found between the two clinical variants. The infiltrate consisted mainly of CD4+ lymphocytes and many neutrophils. CD1a+ dendritic cells were few in both epidermis and dermis. AP introduces a potential source of diagnostic confusion, but increasing experience of this syndrome will improve the awareness and diagnostic potential among dermatologists.
authors.affiliation: Department of Dermatology, Division of Medicine, University of Heraklion, Greece.
authors.forename: M P
authors.initials: MP
authors.lastname: Stefanidou
authors.forename: P E
authors.initials: PE
authors.lastname: Kanavaros
authors.forename: K S
authors.initials: KS
authors.lastname: Stefanaki
authors.forename: A D
authors.initials: AD
authors.lastname: Tosca
mesh_terms: D005260:Female; D006801:Humans; D007402:Intertrigo / Q000150:complications / Q000473:pathology*; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000473:pathology; D008875:Middle Aged; D012595:Scleroderma, Systemic / Q000150:complications / Q000473:pathology; D012872:Skin Diseases, Vesiculobullous / Q000150:complications / Q000473:pathology*