Hereditary spastic paraplegia with a thin corpus callosum and thalamic involvement in Japan.
The authors examined two Japanese siblings with a recessive hereditary spastic paraplegia (HSP) with dementia and a thin corpus callosum. Both showed thalamic glucose hypometabolism on PET. Recessive HSP with a thin corpus callosum is a rare disorder, with less than 20 reported patients, that may be a Japanese subtype of HSP.
Ueda
M
M
Second Department of Internal Medicine, Nippon Medical School Main Hospital, Tokyo, Japan.
Katayama
Y
Y
Kamiya
T
T
Mishina
M
M
Igarashi
H
H
Okubo
S
S
Senda
M
M
Iwabuchi
K
K
Terashi
A
A
D000328:Adult; D001921:Brain / Q000378:metabolism / Q000473:pathology; D003337:Corpus Callosum / Q000378:metabolism / Q000473:pathology*; D005192:Family Health; D006801:Humans; D007564:Japan; D008297:Male; D009679:Nuclear Family; D015419:Spastic Paraplegia, Hereditary / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D013788:Thalamus / Q000378:metabolism / Q000473:pathology*; D014055:Tomography, Emission-Computed