title: Synthesis and evaluation of paclitaxel C7 derivatives: solution phase synthesis of combinatorial libraries.
abstract: A novel and efficient two-step, automated solution phase synthesis of a 26-membered combinatorial chemistry library of paclitaxel C7 esters was accomplished using the HP 7686 Solution Phase Synthesizer. Results of combinatorial synthesis, purification, analysis, and biological evaluation are described.
authors.affiliation: Department of Medicinal Chemistry, Higuchi Bioscience Center, University of Kansas, Lawrence 66045, USA.
authors.forename: L
authors.initials: L
authors.lastname: Bhat
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: S F
authors.initials: SF
authors.lastname: Victory
authors.forename: R H
authors.initials: RH
authors.lastname: Himes
authors.forename: G I
authors.initials: GI
authors.lastname: Georg
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D017239:Paclitaxel / Q000031:analogs & derivatives* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel