[Clinical study on effect of bushen shengxue paste in treating renal anemia patients].
OBJECTIVE
To evaluate the therapeutical mechanism of Bushen Shengxue Paste (BSSXP) on anemia.


METHODS
Chronic renal failure induced anemia patients were treated with BSSXP, clinical manifestation, anemia and renal function as indicators were observed in patients. The erythropoietin (EPO) and inhibition of colony-forming unit-erythrocyte (CFU-E) in patients' serum were determined by CFU-E in vitro.


RESULTS
The patients' symptoms, renal function and anemia were improved after administration with BSSXP 1-2 course. EPO in serum was slightly increased. The inhibition of CFU-E in patient's serum was significantly decreased.


CONCLUSIONS
BSSXP could improve the anemia degree, its mechanism might be through clearing the inhibitor of CFU-E in serum.
Dong
X
X
Institute of Radiation Medicine, Shanghai Medical University.
Shan
G X
GX
Zhang
H D
HD
D000293:Adolescent; D000328:Adult; D000368:Aged; D000740:Anemia / Q000097:blood / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004906:Erythrocyte Count; D015672:Erythroid Precursor Cells / Q000473:pathology; D004921:Erythropoietin / Q000097:blood; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged
D004365:Drugs, Chinese Herbal; D006454:Hemoglobins; D004921:Erythropoietin