Anti-malarial activities of acylated bruceolide derivatives.
Several O-acylated derivatives of bruceolide (2) were synthesized and their anti-malarial activities together with selective toxicities were examined. It was found that 3,15-di-O-acetyl-(3c), 3,15-di-O-propionyl-(3d) and 15-O-propionylbruceolide (3b), as well as bruceine B (3a), exhibited potent anti-malarial activities with high selective toxicities.
Murakami
N
N
Faculty of Pharmaceutical Sciences, Osaka University, Japan.
Umezome
T
T
Mahmud
T
T
Sugimoto
M
M
Kobayashi
M
M
Wataya
Y
Y
Kim
H S
HS
D000215:Acylation; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D005900:Glaucarubin / Q000494:pharmacology*; D051379:Mice; D010963:Plasmodium falciparum / Q000187:drug effects; D014407:Tumor Cells, Cultured
D000962:Antimalarials; D005900:Glaucarubin