title: Asymmetric membrane capsules for osmotic drug delivery. I. Development of a manufacturing process.
abstract: This paper describes a novel non-disintegrating polymeric capsule and a manual and a semi-automatic process developed for its manufacture. The capsule wall was made by a phase inversion process in which the membrane structure was precipitated on stainless steel mold pins by dipping the mold pins into a coating solution containing a polymer-solvent-nonsolvent system followed by dipping into a quench solution. The resulting asymmetric membrane wall was composed of a thin dense region supported on a thicker porous region. The asymmetric membrane capsules can be filled with a blend of the active agent and excipients for use in osmotically modulated controlled drug delivery applications.
authors.affiliation: Pfizer, Inc., Eastern Point Road, Groton, CT 06340, USA.
authors.forename: A G
authors.initials: AG
authors.lastname: Thombre
authors.forename: J R
authors.initials: JR
authors.lastname: Cardinal
authors.forename: A R
authors.initials: AR
authors.lastname: DeNoto
authors.forename: S M
authors.initials: SM
authors.lastname: Herbig
authors.forename: K L
authors.initials: KL
authors.lastname: Smith
mesh_terms: D002214:Capsules; D004339:Drug Compounding; D016503:Drug Delivery Systems; D008567:Membranes, Artificial; D008855:Microscopy, Electron, Scanning; D009994:Osmolar Concentration; D011108:Polymers; D016062:Porosity; D012997:Solvents
chemical_list: D002214:Capsules; D008567:Membranes, Artificial; D011108:Polymers; D012997:Solvents