Some effects of prophylactic aspirins and heparins on concurrent arterial and venous thrombosis in the same animal.
The antithrombotic effect of unfractionated heparin, a low-molecular weight heparin, oral acetylsalicylic acid, intravenous lysine-aspirin and oral soluble aspirin was measured on platinum wire simultaneously in artery and vein, in groups of 12-20 rats with concurrent untreated controls. Subcutaneous low molecular weight heparin reduced mean thrombus weight by 26% in the artery only. Venous thrombosis was reduced 56% by oral soluble acetylsalicylic acid and 27% by oral aspirin. Other reductions did not reach statistical significance. While thrombus deposition was induced by both 2-cm (upper site) and 1-cm (lower site) wires, the results obtained on the 2-cm wires in the upper vein and artery were more reliable [corrected].
Iomhair
M M
MM
Department of Experimental Medicine, Clinical Science Institute, National University of Ireland, Galway.
Lavelle
S M
SM
D000818:Animals; D001018:Aortic Diseases / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D001241:Aspirin / Q000494:pharmacology*; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D006495:Heparin, Low-Molecular-Weight / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013927:Thrombosis / Q000097:blood / Q000150:complications / Q000188:drug therapy; D014682:Vena Cava, Inferior; D020246:Venous Thrombosis / Q000097:blood / Q000150:complications / Q000188:drug therapy*
D005343:Fibrinolytic Agents; D006495:Heparin, Low-Molecular-Weight; D001241:Aspirin