title: Human herpesvirus 6 latently infects early bone marrow progenitors in vivo.
abstract: We have studied the in vivo tropism of human herpesvirus 6 (HHV-6) for hemopoietic cells in patients with latent HHV-6 infection. Having used a variety of cell purification, molecular, cytogenetic, and immunocytochemical procedures, we report the first evidence that HHV-6 latently infects early bone marrow progenitor cells and that HHV-6 may be transmitted longitudinally to cells which differentiate along the committed pathways.
authors.affiliation: Section of Hematology, Department of Medical Sciences, University of Modena, Modena, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Luppi
authors.forename: P
authors.initials: P
authors.lastname: Barozzi
authors.forename: C
authors.initials: C
authors.lastname: Morris
authors.forename: A
authors.initials: A
authors.lastname: Maiorana
authors.forename: R
authors.initials: R
authors.lastname: Garber
authors.forename: G
authors.initials: G
authors.lastname: Bonacorsi
authors.forename: A
authors.initials: A
authors.lastname: Donelli
authors.forename: R
authors.initials: R
authors.lastname: Marasca
authors.forename: A
authors.initials: A
authors.lastname: Tabilio
authors.forename: G
authors.initials: G
authors.lastname: Torelli
mesh_terms: D018952:Antigens, CD34 / Q000032:analysis; D001854:Bone Marrow Cells / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis; D006412:Hematopoietic Stem Cells / Q000821:virology*; D006566:Herpesviridae Infections / Q000821:virology*; D015654:Herpesvirus 6, Human / Q000502:physiology*; D006801:Humans; D016133:Polymerase Chain Reaction; D017735:Virus Latency
chemical_list: D018952:Antigens, CD34; D004279:DNA, Viral