Heteroatom- and carbon-linked biphenyl analogs of Brequinar as immunosuppressive agents.
Structure-activity relationships were explored for some analogs of Brequinar having a linking atom between the 2-biphenyl substituent and the quinoline ring. Activities as inhibitors of dihydroorotate dehydrogenase and the mixed lymphocyte reaction were related to the overall shape and lipophilicity of the 2-substituent.
Batt
D G
DG
DuPont Merck Pharmaceutical Company, Wilmington, Delaware 19880-0500, USA.
Petraitis
J J
JJ
Sherk
S R
SR
Copeland
R A
RA
Dowling
R L
RL
Taylor
T L
TL
Jones
E A
EA
Magolda
R L
RL
Jaffee
B D
BD
D001713:Biphenyl Compounds / Q000737:chemistry; D002244:Carbon / Q000737:chemistry; D007166:Immunosuppressive Agents / Q000737:chemistry* / Q000494:pharmacology*; D007959:Lymphocyte Culture Test, Mixed; D013329:Structure-Activity Relationship
D001713:Biphenyl Compounds; D007166:Immunosuppressive Agents; D002244:Carbon