Rational design of a new series of mixed anti-HIV pronucleotides.
MonoSATE aryl phosphotriesters of AZT are able to deliver intracellularly the corresponding 5'-mononucleotide. This process requires activation by an esterase followed by a phosphodiesterase. This finding opens the way to the design of new pronucleotide series.
Schlienger
N
N
Laboratoire de Chimie Bioorganique, U.M.R. C.N.R.S. 5625, Université Montpellier II, France.
Beltran
T
T
Périgaud
C
C
Lefebvre
I
I
Pompon
A
A
Aubertin
A M
AM
Gosselin
G
G
Imbach
J L
JL
D019380:Anti-HIV Agents / Q000138:chemical synthesis*; D015195:Drug Design; D006801:Humans; D009711:Nucleotides / Q000138:chemical synthesis*; D011355:Prodrugs / Q000138:chemical synthesis*; D015215:Zidovudine / Q000031:analogs & derivatives*
D019380:Anti-HIV Agents; D009711:Nucleotides; D011355:Prodrugs; D015215:Zidovudine