Synthesis and antibacterial activity of 2-alkoxy penems.
The phosphite mediated Oxalimide cyclization reaction was extended to 4-dithiocarbonates of N-oxalyl-2-azetidinones to synthesize 2-alkoxy penems 3. In general, the in vitro antibacterial potency of compounds 3 was weak compared to the highly potent 2-alkylthiopenems 2.
Afonso
A
A
Schering-Plough Research Institute, Kenilworth, New Jersey 07033-0539, USA.
Hon
F
F
Fett
N
N
Weinstein
J
J
Ganguly
A K
AK
Naples
L
L
Hare
R S
RS
Miller
G H
GH
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007769:Lactams; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D007769:Lactams