Synthesis of anti-rheumatic agent epoxyquinomicin B.
Anti-rheumatic agent (+/-)-epoxyquinomicin B was synthesized for a 22% overall yield in eight steps from commercially available 3-hydroxy-4-nitrobenzaldehyde via the intermediate quinone 6 prepared by selective phenol oxidation of 5 by use of Fremy's salt as the key step.
Matsumoto
N
N
Institute of Microbial Chemistry, Tokyo, Japan.
Iinuma
H
H
Sawa
T
T
Takeuchi
T
T
D018501:Antirheumatic Agents / Q000138:chemical synthesis*; D001549:Benzamides / Q000138:chemical synthesis*; D011809:Quinones / Q000138:chemical synthesis*
D018501:Antirheumatic Agents; D001549:Benzamides; D011809:Quinones; C099342:epoxyquinomicin B