[Effects of glycyrrhisin on myocardial ischemia/reperfusion injury of rabbits].
The content of MDA and the activity of creatine phosphokinase (CPK) together with the ultrastructural changes in myocardial tissue were analysed to observe the effects of glycyrrhisin on myocardial ischemia/reperfusion injury in rabbits. The results showed that glycyrrhisin could remarkably reduced the level of MDA and the activity of CPK in myocardial tissue (P < 0.01), and mitigated significantly the myocrdial ultrastructural injury in comparison with ischemia/reperfusion group. It was considered that glycyrrhisin exerted obvious protective effects on myocardial injury induced by ischemia/reperfusion.
Zhang
J
J
Department of Physiology, Hunan Medical School, Changsha.
Li
F
F
Li
Y
Y
Cai
H
H
Xu
Q
Q
D000818:Animals; D003402:Creatine Kinase / Q000378:metabolism; D005260:Female; D016166:Free Radical Scavengers / Q000494:pharmacology*; D019695:Glycyrrhizic Acid / Q000494:pharmacology*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism / Q000648:ultrastructure*; D011817:Rabbits
D016166:Free Radical Scavengers; D008315:Malondialdehyde; D019695:Glycyrrhizic Acid; D003402:Creatine Kinase