title: Pharmacokinetics of phenprobamate after oral administration to healthy subjects.
abstract: Phenprobamate (CAS 673-31-4) is a centrally acting skeletal-muscle relaxant agent. There are only two studies in the literature about the pharmacokinetics of phenoprobamate in man. The inconsistency between the results of these studies can be attributed partly to the different analytical methodologies used. A sensitive, specific and reproducible HPLC-assay, which may increase the reliability of the pharmacokinetic studies of phenprobamate in plasma, has been developed recently. The objective of this investigation was to assess the single-dose kinetics of phenprobamate in human and to determine the pharmacokinetic parameters of clinical and regulatory concern. The plasma pharmacokinetics of phenprobamate have been investigated following single oral administration at a dose of 800 mg in eleven healthy volunteers.
authors.affiliation: Department of Pharmacology and Clinical Pharmacology, Faculty of Medicine, Ankara University, Turkey.
authors.forename: F C
authors.initials: FC
authors.lastname: Tulunay
authors.forename: H O
authors.initials: HO
authors.lastname: Onaran
authors.forename: H
authors.initials: H
authors.lastname: Ergün
authors.forename: A
authors.initials: A
authors.lastname: Ucar
authors.forename: S
authors.initials: S
authors.lastname: Usanmaz
authors.forename: K
authors.initials: K
authors.lastname: Embil
authors.forename: M
authors.initials: M
authors.lastname: Tulunay
mesh_terms: D000293:Adolescent; D000328:Adult; D019540:Area Under Curve; D002219:Carbamates / Q000493:pharmacokinetics*; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D009125:Muscle Relaxants, Central / Q000493:pharmacokinetics*
chemical_list: D002219:Carbamates; D009125:Muscle Relaxants, Central; C008837:phenprobamate