title: Variable distribution of TFF2 (Spasmolysin) alleles in Europeans does not indicate predisposition to gastric cancer.
abstract: Peptides belonging to the trefoil factor family (TFF) protect the gastrointestinal epithelia. Overexpression of TFFs was observed in pathological conditions such as gastritis, ulceration, metaplasia and neoplasia of the gastrointestinal tract. The aims of this work were to investigate the recently described TFF2 gene polymorphism in different European populations. DNA samples from blood of healthy individuals and gastric cancer patients were genotyped using the polymerase chain reaction. They were compared to a gastric cancer population. The results do not show any significant difference in allelic frequencies between gastric cancer patients and healthy individuals from Portugal. However, the frequency of the two alleles found varies considerably among Europeans.
authors.affiliation: Division of Molecular Genetics, Department of Anthropology and Human Genetics, University of Tübingen, Germany.
authors.forename: E
authors.initials: E
authors.lastname: dos Santos Silva
authors.forename: T
authors.initials: T
authors.lastname: Kayademir
authors.forename: F
authors.initials: F
authors.lastname: Regateiro
authors.forename: J C
authors.initials: JC
authors.lastname: Machado
authors.forename: S
authors.initials: S
authors.lastname: Savas
authors.forename: T
authors.initials: T
authors.lastname: Dobosz
authors.forename: N
authors.initials: N
authors.lastname: Blin
authors.forename: P
authors.initials: P
authors.lastname: Gött
mesh_terms: D000483:Alleles; D005060:Europe; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006133:Growth Substances / Q000235:genetics*; D006801:Humans; D009077:Mucins; D009124:Muscle Proteins; D009479:Neuropeptides; D010455:Peptides / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D013274:Stomach Neoplasms / Q000235:genetics*; D020080:Tandem Repeat Sequences; D000071164:Trefoil Factor-2; D000071165:Trefoil Factor-3
chemical_list: D006133:Growth Substances; D009077:Mucins; D009124:Muscle Proteins; D009479:Neuropeptides; D010455:Peptides; C000604007:TFF2 protein, human; C099037:TFF3 protein, rat; C000604008:Tff2 protein, rat; D000071164:Trefoil Factor-2; D000071165:Trefoil Factor-3