Total synthesis of fentanyl.
Fentanyl of a potent anilidopiperidine analgesic has been synthesized from a simple phenylethylamine by four step sequence. The key part of this synthesis involves an efficient construction of phenylethylpiperidone skeleton via aminomethano desilyltion-cyclization followed by Swern oxidation.
Suh
Y G
YG
College of Pharmacy, Seoul National University, Korea.
Cho
K H
KH
Shin
D Y
DY
D000701:Analgesics, Opioid / Q000138:chemical synthesis*; D003500:Cyclization; D005283:Fentanyl / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D010084:Oxidation-Reduction; D010880:Piperidines / Q000737:chemistry
D000701:Analgesics, Opioid; D007202:Indicators and Reagents; D010880:Piperidines; D005283:Fentanyl