Preparation of alpha-keto ester enol acetates as potential prodrugs of human neutrophil elastase inhibitors.
Enol acetates of a-keto esters with E configuration were prepared as potential prodrugs for human neutrophil elastase (HNE) inhibitors.
Burkhart
J P
JP
Hoechst Marion Roussel, Cincinnati, Ohio 45215, USA.
Mehdi
S
S
Koehl
J R
JR
Angelastro
M R
MR
Bey
P
P
Peet
N P
NP
D000085:Acetates / Q000737:chemistry*; D004952:Esters; D006801:Humans; D019272:Leukocyte Elastase / Q000037:antagonists & inhibitors*; D011355:Prodrugs / Q000138:chemical synthesis* / Q000494:pharmacology; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology
D000085:Acetates; D004952:Esters; D011355:Prodrugs; D011480:Protease Inhibitors; D019272:Leukocyte Elastase