Long-term mechanical circulatory support system reliability recommendation: American Society for Artificial Internal Organs and The Society of Thoracic Surgeons: long-term mechanical circulatory support system reliability recommendation.
Jointly developed by members of the American Society for Artificial Internal Organs and the Society of Thoracic Surgeons along with staff from the Food and Drug Administration, the National Heart, Lung and Blood Institute and other experts, this recommendation describes the reliability considerations and goals for Investigational Device Exemption and Premarket Approval submissions for long-term, mechanical circulatory support systems. The recommendation includes a definition of system failure, a discussion of an appropriate reliability model, a suggested in vitro reliability test plan, reliability considerations for animal implantation tests, in vitro and animal in vivo performance goals, the qualification of design changes during the Investigational Device Exemption clinical trial, the development of a Failure Modes Effects and Criticality Analysis, and the reliability information for surgeons and patient candidates. The document will be periodically reviewed to assess its timeliness and appropriateness within five years.
Pantalos
G M
GM
Artificial Heart Research Laboratory, Institute for Biomedical Engineering, University of Utah, Salt Lake City 84103-1414, USA.
Altieri
F
F
Berson
A
A
Borovetz
H
H
Butler
K
K
Byrd
G
G
Ciarkowski
A A
AA
Dunn
R
R
Frazier
O H
OH
Griffith
B
B
Hoeppner
D W
DW
Jassawalla
J S
JS
Kormos
R H
RH
Kung
R T
RT
Lemperle
B
B
Lewis
J P
JP
Pennington
D G
DG
Poirier
V L
VL
Portner
P M
PM
Rosenberg
G
G
Shanker
R
R
Watson
J T
JT
D000818:Animals; D001187:Artificial Organs; D004867:Equipment Design; D004868:Equipment Failure; D006353:Heart-Assist Devices / Q000592:standards*; D006801:Humans; D018579:Patient Selection; D012955:Societies, Medical; D013903:Thoracic Surgery; D014481:United States