[The mechanisms of the lymph-stimulating action of liposomes].
The mechanisms of lymph-stimulating action of different liposomes (lecithin-cholesterin, lecithin) were studied in the experiments on dogs. It has been shown an absence of interaction between changes in the lymph outflow rate and system circulation parameters when injecting any liposomes. Moreover, water and protein filtration from the vascular bed into the interstitial space was lowered due to liposomal injection. But oxygen tension in the muscular tissues remained on the level closed to the normal one. In contrast to the intravenous injection, the subcutaneous administration of liposomes has induced the stimulation of lymph outflow, which was more expressed on both volume (nearly by 40%) and duration (nearly by 50%). The experiments with limited and crossed blood flow have demonstrated a regional character of liposomal lymph-stimulating. The mechanisms of such liposomal action may be related to both direct action of liposomes on the lymphatic smooth muscle contractility in the lymphatic vessels and the increased lymph production in the site of liposomal injection due to free radical oxidation processes being limited in that area. The micellar form of phospholipids (essential) has demonstrated no lymph-stimulating action.
Khromov
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D000818:Animals; D001775:Blood Circulation / Q000187:drug effects; D002307:Cardiography, Impedance; D002404:Catheterization; D002784:Cholesterol / Q000008:administration & dosage / Q000494:pharmacology; D004285:Dogs; D008081:Liposomes / Q000008:administration & dosage / Q000494:pharmacology*; D008196:Lymph / Q000187:drug effects* / Q000502:physiology; D010713:Phosphatidylcholines / Q000008:administration & dosage / Q000494:pharmacology; D013268:Stimulation, Chemical; D013897:Thoracic Duct
D008081:Liposomes; D010713:Phosphatidylcholines; D002784:Cholesterol
Vyvchennia mekhanizmiv limfostymuliuiuchoï diï liposom.