Stability of acetal and non acetal-type analogs of artemisinin in simulated stomach acid.
A series of non acetal-type analogs of artemisinin containing C-C bond at position-12 have been found to be 15-22 times more stable than acetal(C-O)-type prodrugs of artemisinin in simulated stomach acid.
Jung
M
M
Department of Chemistry, Yonsei University, Seoul, Korea.
Lee
S
S
D000080:Acetals; D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D037621:Artemisinins; D015195:Drug Design; D004355:Drug Stability; D005744:Gastric Acid; D006801:Humans; D006868:Hydrolysis; D007700:Kinetics; D008958:Models, Molecular; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D013329:Structure-Activity Relationship
D000080:Acetals; D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; C031327:artemisinin