[Effect of x-irradiation on the properties of cyclic AMP-dependent protein kinases from rat spleen lymphocytes].
It was shown, that in conditions of acute radiation affection in doze 0.5 and 1 Gy, there was a decrease of 32 and 55% in activity of cyclic AMP-dependent protein kinases, isolated from cytosol of lymphocytes. The analysis of cAMP-dependent protein kinases properties has shown, that disturbance in the interaction of the enzyme with protein substrate of phosphotransferase reaction and main modulater enzymes activity--cAMP proceeds of the ionising radiation effect.
Ostapchenko
L I
LI
Shevchenko State Kiev University, Ukraine.
Nalevina
O E
OE
Tomachinskaia
L I
LI
Kucherenko
N E
NE
D000818:Animals; D017868:Cyclic AMP-Dependent Protein Kinases / Q000528:radiation effects*; D003600:Cytosol / Q000201:enzymology / Q000528:radiation effects; D008214:Lymphocytes / Q000201:enzymology / Q000528:radiation effects*; D008297:Male; D010766:Phosphorylation; D051381:Rats; D013154:Spleen / Q000201:enzymology / Q000276:immunology / Q000528:radiation effects*; D013379:Substrate Specificity
D017868:Cyclic AMP-Dependent Protein Kinases
Vliianie rentgenovskogo oblucheniia na svoĭstva tsAMF-zavisimykh proteinkinaz iz limfotsitov selezenki krys.