Maximum workplace concentration values and carcinogenicity classification for mixtures.
In Germany, the Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK Commission) generally sets maximum workplace concentration values (i.e., a proposed occupational exposure level [OEL]) for single substances, not for mixtures. For mixtures containing substances with a genotoxic and carcinogenic potential, the commission considered it scientifically inappropriate to establish a safe threshold. This approach is currently under discussion. Carcinogenic mixtures are categorized according to either the carcinogenicity of the mixture or the classification of the carcinogenic substances included. In regulating exposure to mixtures, an approach similar to that used by the American Conference of Governmental Hygienists is proposed: For components with the same target organ and mode of action or interfering metabolism, synergistic effects must be expected and the respective OELs must be lowered. However, if there is proof that the components act independently, the OELs of the individual compounds are not considered to be modified. In the view of the commission, calculating OELs for solvent mixtures according to their liquid phase composition is not justified, and the setting of scientifically based OELs for complex mixtures is not possible.
Bartsch
R
R
GSF-Institute for Toxicology, Neuherberg, Germany. bartsch@gsf.de
Forderkunz
S
S
Reuter
U
U
Sterzl-Eckert
H
H
Greim
H
H
D002273:Carcinogens / Q000032:analysis / Q000633:toxicity*; D004347:Drug Interactions; D005858:Germany; D006801:Humans; D008452:Maximum Allowable Concentration; D016273:Occupational Exposure / Q000009:adverse effects* / Q000331:legislation & jurisprudence
D002273:Carcinogens