Soluble tumor necrosis factor alpha receptors in sera from leprosy patients.
Serum levels of soluble tumor necrosis factor alpha receptor I (sTNF-RI) were elevated in patients with lepromatous (LL) reactional-state type II leprosy, and sTNF-RII levels were increased in patients with full tuberculoid (TT) or LL type II leprosy. The sTNF-R in sera from patients with type II leprosy, but not other forms of leprosy, inhibited recombinant TNF cytolytic activities in vitro. This suggests that sTNF-R regulatory activities are partially impaired in patients with leprosy.
Munk
M E
ME
Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany. munk@mpiib-berlin.mpg.de
Anding
P
P
Schettini
A P
AP
Cunha
M G
MG
Kaufmann
S H
SH
D000328:Adult; D000818:Animals; D015703:Antigens, CD / Q000097:blood* / Q000502:physiology; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D006801:Humans; D007918:Leprosy / Q000097:blood* / Q000188:drug therapy / Q000276:immunology; D015441:Leprosy, Tuberculoid / Q000097:blood / Q000188:drug therapy / Q000276:immunology; D008297:Male; D051379:Mice; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood* / Q000502:physiology; D047888:Receptors, Tumor Necrosis Factor, Type I; D047889:Receptors, Tumor Necrosis Factor, Type II; D012995:Solubility; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
D015703:Antigens, CD; D018124:Receptors, Tumor Necrosis Factor; D047888:Receptors, Tumor Necrosis Factor, Type I; D047889:Receptors, Tumor Necrosis Factor, Type II; D014409:Tumor Necrosis Factor-alpha