title: Synthesis of benzanilide derivatives as dual acting agents with alpha 1-adrenoceptor antagonistic action and steroid 5-alpha reductase inhibitory activity.
abstract: Synthesis of benzanilide derivatives which have dual alpha 1-adrenoceptor antagonistic action and steroid 5 alpha-reductase inhibitory activity and their structure-activity relationships is described.
authors.affiliation: Central Research Laboratories, Zeria Pharmaceutical Co., Ltd., Saitama, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yoshida
authors.forename: Y
authors.initials: Y
authors.lastname: Horikoshi
authors.forename: M
authors.initials: M
authors.lastname: Eta
authors.forename: J
authors.initials: J
authors.lastname: Chikazawa
authors.forename: M
authors.initials: M
authors.lastname: Ogishima
authors.forename: Y
authors.initials: Y
authors.lastname: Fukuda
authors.forename: H
authors.initials: H
authors.lastname: Sato
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D000813:Anilides / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D042944:Cholestenone 5 alpha-Reductase; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D010088:Oxidoreductases / Q000037:antagonists & inhibitors*; D011817:Rabbits; D013329:Structure-Activity Relationship
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists; D000813:Anilides; D004791:Enzyme Inhibitors; C034595:benzanilide; D010088:Oxidoreductases; D042944:Cholestenone 5 alpha-Reductase