title: A potent and selective inhibition of parainfluenza 1 (Sendai) virus by new 6-oxiranyl-, 6-methyloxiranyluracils, and 4(3H)-pyrimidinone derivatives.
abstract: Several new 6-oxiranyl-, 6-methyloxiranyluracils, and pyrimidinone derivatives, synthesized by the lithiation-alkylation sequence of 1,3,6-trimethyluracil, 1,3-dimethyl-6-chloromethyluracil, and 2-alkoxy-6-methyl-4(3H)-pyrimidinones, showed a potent and selective antiviral activity against the parainfluenza 1(Sendai) virus replication.
authors.affiliation: Dipartimento Agrochimico Agrobiologico, Università degli studi di Viterbo La Tuscia, Italy. Saladino@unitus.it
authors.forename: R
authors.initials: R
authors.lastname: Saladino
authors.forename: M C
authors.initials: MC
authors.lastname: Danti
authors.forename: E
authors.initials: E
authors.lastname: Mincione
authors.forename: C
authors.initials: C
authors.lastname: Crestini
authors.forename: A T
authors.initials: AT
authors.lastname: Palamara
authors.forename: P
authors.initials: P
authors.lastname: Savini
authors.forename: S
authors.initials: S
authors.lastname: Marini
authors.forename: M
authors.initials: M
authors.lastname: Botta
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D004285:Dogs; D011744:Pyrimidinones / Q000737:chemistry / Q000494:pharmacology*; D018108:Respirovirus / Q000187:drug effects* / Q000502:physiology; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D011744:Pyrimidinones