[A case of Parkinson syndrome secondary to combined amineptine and bromazepam abuse].
A case report of parkinsonism secondary to chronic abuse of amineptine (3 gr/day) and bromazepam (35 mg/day) in a patient diagnosed of borderline personality disorder is presented. The patient did not take any other drugs and he was not recently on neuroleptic treatment; he recognized the abuse of amineptine, as a stimulant, and the bromazepam abuse, looking for a relief to the excessive anxiety secondary to amineptine. The parkinsonism improved after removing both drugs and taking biperiden and diazepam; lastly the patient was discharged without any medication. The patient did not suffer from other complications associated with amineptine or bromazepam abuse. There are some cases reported of parkinsonism secondary to benzodiazepines but there is none secondary to amineptine. We present a short review of the possible responsible mechanisms, thinking on a complex interaction of both drugs on dopamine and its modulatory systems.
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Servicio de Psiquiatria, Hospital General Universitario, Murcia, Espagne.
Pozo
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Romero
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Barcia
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D000328:Adult; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001883:Borderline Personality Disorder / Q000175:diagnosis / Q000523:psychology; D001960:Bromazepam / Q000008:administration & dosage / Q000009:adverse effects*; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000009:adverse effects*; D003986:Dibenzocycloheptenes / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D009460:Neurologic Examination / Q000187:drug effects; D010302:Parkinson Disease, Secondary / Q000139:chemically induced* / Q000175:diagnosis / Q000523:psychology; D019966:Substance-Related Disorders / Q000175:diagnosis* / Q000523:psychology / Q000534:rehabilitation
D014151:Anti-Anxiety Agents; D000697:Central Nervous System Stimulants; D003986:Dibenzocycloheptenes; C011597:amineptin; D001960:Bromazepam
Un cas de syndrome parkinsonien secondaire à la surconsommation d'amineptine et de bromazépam.