title: Diimidazo[1,2-c:4',5'-e]pyrimidines: N6-N1 conformationally restricted adenosines.
abstract: Tethering the N6-substituents of N6-substituted adenosines to N1 has resulted in a series of conformationally restricted adenosine analogues. The resultant diimidazo[1,2-c:4',5'-e]pyrimidines were shown to be adenosine A1 selective.
authors.affiliation: Queensland Pharmaceutical Research Institute, Griffith University, Brisbane, Australia.
authors.forename: D
authors.initials: D
authors.lastname: Camp
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: A
authors.initials: A
authors.lastname: McCluskey
authors.forename: R W
authors.initials: RW
authors.lastname: Moni
authors.forename: R J
authors.initials: RJ
authors.lastname: Quinn
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D002478:Cells, Cultured; D003342:Corpus Striatum / Q000378:metabolism; D006801:Humans; D008956:Models, Chemical; D010660:Phenylisopropyladenosine / Q000031:analogs & derivatives* / Q000378:metabolism; D058906:Purinergic P1 Receptor Agonists; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000378:metabolism*; D051381:Rats; D018047:Receptors, Purinergic P1 / Q000378:metabolism
chemical_list: D058906:Purinergic P1 Receptor Agonists; D011743:Pyrimidines; D018047:Receptors, Purinergic P1; D010660:Phenylisopropyladenosine