NSF--fusion and beyond.
NSF (N-ethylmaleimide-sensitive fusion protein) was the first protein to be isolated as a crucial factor in intracellular membrane-fusion events, such as the fusion of synaptic vesicles with the presynaptic membrane during neurotransmission. Although the activation of membrane SNARE proteins for subsequent fusion is clearly a primary role of NSF, recent studies have provided surprising evidence that NSF also interacts with glutamate receptors at the postsynaptic membrane in a way that does not seem to involve SNAREs. These results suggest that NSF might act as a molecular chaperone not only on SNAREs but also of other proteins.
Haas
A
A
Lehrstuhl für Mikrobiologie, Biozentrum der Universität, Würzburg, Germany. haas@biozentrum.uni-wuerzburg.de
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D005033:Ethylmaleimide; D008565:Membrane Proteins / Q000378:metabolism; D052066:N-Ethylmaleimide-Sensitive Proteins; D018091:Receptors, AMPA / Q000378:metabolism; D050600:SNARE Proteins; D033921:Vesicular Transport Proteins
D002352:Carrier Proteins; D008565:Membrane Proteins; D018091:Receptors, AMPA; D050600:SNARE Proteins; D033921:Vesicular Transport Proteins; D052066:N-Ethylmaleimide-Sensitive Proteins; D005033:Ethylmaleimide