title: Intracerebral hemorrhage as a late complication after CNS treatment of childhood lymphoma.
abstract: Since the majority of children with acute leukemia and lymphoma are long-term survivors, more attention is directed towards late sequelae of therapy. Intracerebral hemorrhage after treatment of central nervous system (CNS) neoplasia in childhood is a very rare event. A seven and a half-year-old boy was admitted to our hospital because of acute third nerve palsy. Three years and eight months before the patient had been treated for a mediastinal T-cell non Hodgkin's lymphoma (T-NHL) with CNS involvement by combined chemo-radiotherapy. Recurrent disease was excluded, but intracerebral hemorrhage in the tectal area was demonstrated by repeated magnetic resonance imaging. Symptoms of incomplete oculomotor paresis improved spontaneously with conservative therapy. Intracerebral hemorrhage may occur as a rare complication in children with malignant CNS disease even years after treatment with combined chemo-radiotherapy.
authors.affiliation: University of Kiel, Department of Pediatrics, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Claviez
authors.forename: B
authors.initials: B
authors.lastname: Neubauer
authors.forename: J
authors.initials: J
authors.lastname: Link
authors.forename: R
authors.initials: R
authors.lastname: Schneppenheim
mesh_terms: D016543:Central Nervous System Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary*; D002543:Cerebral Hemorrhage / Q000139:chemically induced / Q000175:diagnosis / Q000209:etiology*; D002648:Child; D003131:Combined Modality Therapy / Q000009:adverse effects; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy; D008279:Magnetic Resonance Imaging; D008297:Male