[Vascular endothelial cells and renin-angiotensin system].
The vascular renin-angiotensin system (RAS) is regulated independently from circulating RAS and plays a role in the local regulation of vascular tone, the modulation of sympathetic activity and vascular remodeling. Endothelial cells are a major source of angiotensin converting enzyme (ACE), which produces angiotensin II and degrades bradykinin, in normal arteries. Mechanical stress such as transmural pressure, stretch stress and shear stress appear to contribute to the regulation of endothelial ACE activity. In contrast, vessels with intimal proliferation such as atheromatous plaque and neointima following balloon injury show expression of ACE in smooth muscle cells and macrophages in the intimal lesions. Activation of ACE in intimal SMC may relate to a phenotypic change of SMC from the contracting type of the synthetic type. Activation of ACE in macrophages is also related to the transformation of macrophages from monocytes. Concerning the role of the activated RAS, elevated blood pressure and vascular tonus by angiotensin II are candidates of vascular injury and plaque rupture. Angiotensin II stimulates migration and proliferation of smooth muscle cells and production of extracellular matrix. Furthermore, angiotensin II increases oxidized-LDL which may be related to the forming of macrophages. These evidence suggest that activation of vascular RAS following endothelial dysfunction/injury play an important role in the pathogenesis of vascular remodeling and atherosclerosis.
Rakugi
H
H
Department of Geriatric Medicine, Osaka University Medical School, Suita.
Nakamura
Y
Y
Ohishi
M
M
Okamura
A
A
Yanagitani
Y
Y
Higaki
J
J
Ogihara
T
T
D000818:Animals; D004730:Endothelium, Vascular / Q000166:cytology / Q000473:pathology / Q000502:physiology*; D006801:Humans; D012084:Renin-Angiotensin System / Q000502:physiology*; D014652:Vascular Diseases / Q000503:physiopathology