title: Biological skin covers in treatment of two cases of the Lyell's syndrome.
abstract: The treatment of two cases of toxic epidermal necrolysis (Lyell's syndrome) is described. Although some features were common for both ones (young men practically of the same age, reaction after using the same drug) the clinical course of illness was very different. Spontaneous epithelisation of partial-thickness lesions and definitive healing under the xenografts in one patient and full-thickness skin-loss on 12% of body surface with severe septic complications requiring application of cultured keratinocytes and/or skin autografting in the other patient were the main differences. The interdisciplinary approach using a burns treatment protocol in non-burned patient including the close co-operation with the tissue bank in preparing different types of biological covers has been applied.
authors.affiliation: Dept. of Plastic Surgery and Burns Treatment, Teaching Hospital Purkinje Military Medical Academy. ferko@pmf.pmfhk.cz
authors.forename: L
authors.initials: L
authors.lastname: Klein
authors.forename: P
authors.initials: P
authors.lastname: Mĕricka
authors.forename: H
authors.initials: H
authors.lastname: Straková
authors.forename: L
authors.initials: L
authors.lastname: Jebavý
authors.forename: M
authors.initials: M
authors.lastname: Nozicková
authors.forename: M
authors.initials: M
authors.lastname: Bláha
authors.forename: Z
authors.initials: Z
authors.lastname: Talábová
authors.forename: F
authors.initials: F
authors.lastname: Hosek
mesh_terms: D000293:Adolescent; D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D007116:Immunization, Passive; D008297:Male; D016038:Skin Transplantation; D013262:Stevens-Johnson Syndrome / Q000523:psychology / Q000628:therapy*; D014183:Transplantation, Heterologous; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects*; D014545:Urinary Calculi / Q000150:complications / Q000188:drug therapy
chemical_list: D000890:Anti-Infective Agents; D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; D015662:Trimethoprim, Sulfamethoxazole Drug Combination