[Hemodynamic chronosensitivity to metopress-retard in patients with stage ii hypertension].
Time-dependent effects of metopress-retard (TEVA, Israel) were studied in 38 patients with stage II hypertension who were randomized to two groups, 19 patients each. Group 1 received 100 mg of metopress-retard at 8 a.m., group 2--at 8 p.m. Before the drug was taken and each 2 hours for 12 running hours after its 100 mg intake hemodynamic parameters were measured non-invasively. It was found that metopress-retard had no negative chronotropic and more strong hypotensive effects when taken in the evening (at 20.00).
Zaslavskaia
R M
RM
Zhumabaeva
T N
TN
Zhamankulov
K A
KA
Teĭblium
M M
MM
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage* / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects*; D019454:Chronotherapy; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
D000319:Adrenergic beta-Antagonists
Khronochuvstvitel'nost' pokazateleĭ gemodinamiki u bol'nykh gipertonicheskoĭ bolezn'iu II stadii k metopressu-retardu.