title: Semirigid or flexible mitral annuloplasty rings do not affect global or basal regional left ventricular systolic function.
abstract: BACKGROUND
  Previous studies have revealed that rigid mitral annuloplasty rings may be associated with left ventricular (LV) systolic dysfunction, but whether ring type affects regional systolic function at the base of the LV, in the region near the mitral annulus, is unclear. We tested the hypothesis that rigid fixation of the mitral annulus results in significant regional systolic dysfunction at the base of the LV.
  
  
  RESULTS
  Twenty-six adult male sheep underwent placement of 13 miniature tantalum markers into the LV epicardium and around the mitral annulus to allow calculation of LV volume and regional epicardial area. Group I (n = 7) sheep served as controls; animals randomized to groups II (n = 11) and III (n = 8) underwent mitral annuloplasty with either a semirigid or flexible ring, respectively. After a 7- to 10-day recovery period, animals were studied in a closed-chest, sedated, autonomically blocked state. Global LV systolic function (end-systolic elastance and preload recruitable stroke work) were not significantly different among the 3 groups (P = 1.0, ANOVA). Regional systolic function at the base of the LV (fractional area shrinkage [FAS] of 4 epicardial areas) at comparable LV preload and afterload was similar in the 4 basal areas (P = 0.223, MANOVA). With the use of load-insensitive indexes (slope and area intercept of the end-systolic pressure-regional area relationship and regional stroke work-end-diastolic area relationship), regional systolic function also was not different between groups at baseline or with inotropic stimulation in any basal region (P > 0.05, MANOVA). Furthermore, neither annuloplasty ring perturbed the regional pattern of basal LV systolic function.
  
  
  CONCLUSIONS
  Postoperative LV systolic function, both globally and in the region of the base of the LV (near the mitral annulus), was not altered with either semirigid or flexible ring fixation of the mitral annulus.
authors.affiliation: Department of Cardiovascular and Thoracic Surgery, Stanford University School of Medicine, CA 94305-5247, USA.
authors.forename: G R
authors.initials: GR
authors.lastname: Green
authors.forename: P
authors.initials: P
authors.lastname: Dagum
authors.forename: J R
authors.initials: JR
authors.lastname: Glasson
authors.forename: G T
authors.initials: GT
authors.lastname: Daughters
authors.forename: A F
authors.initials: AF
authors.lastname: Bolger
authors.forename: L E
authors.initials: LE
authors.lastname: Foppiano
authors.forename: N B
authors.initials: NB
authors.lastname: Ingels
authors.forename: D C
authors.initials: DC
authors.lastname: Miller
mesh_terms: D000818:Animals; D004867:Equipment Design; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation; D006439:Hemodynamics / Q000502:physiology; D008297:Male; D012756:Sheep; D013599:Systole; D016277:Ventricular Function, Left / Q000502:physiology*