[Effect of continuous intravenous tocolysis with beta 2-mimetics and magnesium sulfate on erythropoietin level].
14 pregnant women receiving continuous intravenous tocolysis for threatened miscarriage were studied for an effect of beta 2-mimetics on erythropoiesis in humans. After tocolytic therapy for 48 h, the hematokrit fell by 14%; conversely erythropoietin levels rose by 88.7%. Increased erythropoiesis was reflected in increased reticulocyte (and reticulocyte subpopulation) counts. There was a significant correlation between cumulative tocolytic dose and erythropoietin elevation at 48 h. The hypervolemia evidenced by the decreased hematocrit was due to the increased oral fluid intake and fluid retention, and was the presumed main cause of the elevated erythropoietin levels. This effect could enhance understanding of the control of erythropoietin secretion. A similar mechanism may account for the increase in erythropoietin levels in pregnancy.
Hüttner
C
C
Departement Frauenheilkunde, Universitätsspital Zürich.
Breymann
C
C
Huch
R
R
Huch
A
A
D000328:Adult; D001810:Blood Volume / Q000187:drug effects; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D004921:Erythropoietin / Q000097:blood*; D005260:Female; D005280:Fenoterol / Q000008:administration & dosage* / Q000009:adverse effects; D006400:Hematocrit; D006801:Humans; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D008278:Magnesium Sulfate / Q000008:administration & dosage* / Q000009:adverse effects; D007752:Obstetric Labor, Premature / Q000097:blood / Q000517:prevention & control*; D011247:Pregnancy; D013566:Sympathomimetics / Q000008:administration & dosage* / Q000009:adverse effects; D015145:Tocolysis
D013566:Sympathomimetics; D004921:Erythropoietin; D005280:Fenoterol; D008278:Magnesium Sulfate
Einfluss der intravenösen Dauertokolyse mit beta 2 -Mimetika und Magnesiumsulfat auf den Erythropoietin-Spiegel.