A controlled trial of two bicarbonate-containing dialysis fluids for CAPD--final report.
BACKGROUND
The combination of a low pH and a high concentration of lactate which is present in most dialysis fluids is found to be cytotoxic in vitro. For these reasons it would seem logical to use a bicarbonate-containing solution and thus automatically provide a solution with a neutral pH.


METHODS
A parallel, randomized, open-label, prospective 2-month trial with an optional 4 month extension was undertaken to compare two novel bicarbonate-based solutions; one containing 38 mmol/l of bicarbonate (B), and one containing a mixture of 25 mmol/l bicarbonate and 15 mmol/l of lactate (B/L), with a control solution (C) containing 40 mmol/l lactate.


RESULTS
Three groups of 19 (C), 20 (B), and 20 (B/L) patients were recruited and data from approximately 55 patient months were accumulated in each group. The data show that both bicarbonate-based solutions maintain acid-base levels within the normal range, that there were no changes in any of the other blood biochemistry parameters measured in the peritoneal equilibration test or with regard to adequacy of dialysis, and that furthermore, both solutions were well tolerated.


CONCLUSIONS
This study showed that either the bicarbonate or bicarbonate/lactate solutions could be utilized efficaciously in patients undergoing CAPD.
Coles
G A
GA
Cardiff Royal Infirmary, UK.
O'Donoghue
D J
DJ
Pritchard
N
N
Ogg
C S
CS
Jani
F M
FM
Gokal
R
R
Cancarini
G C
GC
Maiorca
R
R
Tranaeus
A
A
De Vos
C
C
Hopwood
A
A
Faict
D
D
D000136:Acid-Base Equilibrium / Q000187:drug effects; D001639:Bicarbonates / Q000008:administration & dosage* / Q000009:adverse effects; D001692:Biological Transport / Q000187:drug effects; D015314:Dialysis Solutions / Q000009:adverse effects / Q000627:therapeutic use*; D004338:Drug Combinations; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology; D019344:Lactic Acid / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory; D010537:Peritoneum / Q000378:metabolism; D011446:Prospective Studies
D001639:Bicarbonates; D015314:Dialysis Solutions; D004338:Drug Combinations; D019344:Lactic Acid