Biosynthetic pathway of citrinin in the filamentous fungus monascus ruber as revealed by 13C nuclear magnetic resonance
Carbon isotope distribution of [13C]citrinin from Monascus ruber incubated with [13C]acetate revealed that the biosynthesis of the toxin originated from a tetraketide, instead of a pentaketide as has been shown for Penicillium and Aspergillus species. The production of polyketide red pigments and citrinin by M. ruber may therefore be regulated at the level of the tetraketide branch point.
Hajjaj
H
Centre Bioingenierie Gilbert Durand, CNRS UMR 5504, LA INRA, Institut National des Sciences Appliquees de Toulouse, Complexe Scientifique de Rangueil, Toulouse, France.
Klaebe
A
Loret
MO
Goma
G
Blanc
PJ
Francois
J