title: Technique of lymphatic mapping and sentinel node biopsy for melanoma.
abstract: OBJECTIVE
  An increasing number of surgeons perform sentinel node biopsy to identify melanoma patients with early lymphatic dissemination who may benefit from regional node dissection or adjuvant therapy. The addition of lymphoscintigraphy and intraoperative gamma-ray detection with a hand-held probe increases the sensitivity of the surgical technique substantially.
  
  
  METHODS
  The value of lymphoscintigraphy is discussed. The operative technique of lymphatic mapping and sentinel node biopsy is described, including the use of a vital dye and a gamma-ray probe.
  
  
  CONCLUSIONS
  Close to 100% of first-tier lymph nodes can be identified with this combined approach without the unnecessary removal of too many higher-echelon nodes.
authors.affiliation: Department of Surgery, The Netherlands Cancer Institute, Amsterdam.
authors.forename: O E
authors.initials: OE
authors.lastname: Nieweg
authors.forename: L
authors.initials: L
authors.lastname: Jansen
authors.forename: B B
authors.initials: BB
authors.lastname: Kroon
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy / Q000379:methods*; D003937:Diagnosis, Differential; D005260:Female; D005720:Gamma Rays; D006801:Humans; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging*; D008297:Male; D008545:Melanoma / Q000000981:diagnostic imaging* / Q000556:secondary*; D008875:Middle Aged; D011877:Radionuclide Imaging; D012878:Skin Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*