Two novel oleanolic acid saponins having a sialyl Lewis X mimetic structure from Achyranthes fauriei root.
Two novel triterpene glycosides, achyranthosides E and F, were isolated as methyl esters from the root of Achyranthes fauriei, an antiinflammatory medicinal plant. Their structures were characterized as oleanolic acid glucuronides having unique substituents composed of C6H9O5 and C9H15O7, respectively, at the C-3 position of glucuronic acid. These compounds are active components which can inhibit the excess recruiting of neutrophiles to injured tissues 1,000 times more potently than sialyl Lewis X.
Ida
Y
Y
School of Pharamaceutical Sciences, Showa University, Tokyo, Japan. ida@pharm.showa-u.ac.jp
Satoh
Y
Y
Katsumata
M
M
Nagasao
M
M
Hirai
Y
Y
Kajimoto
T
T
Katada
N
N
Yasuda
M
M
Yamamoto
T
T
D009682:Magnetic Resonance Spectroscopy; D018716:Molecular Mimicry; D009828:Oleanolic Acid / Q000737:chemistry*; D009844:Oligosaccharides / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D000080506:Sialyl Lewis X Antigen; D016339:Spectrometry, Mass, Fast Atom Bombardment
D009844:Oligosaccharides; D000080506:Sialyl Lewis X Antigen; D009828:Oleanolic Acid