title: Germinated barley foodstuff increases fecal volume and butyrate production in humans.
abstract: Germinated barley foodstuff (GBF), derived from the aleurone layer, scutellum and germ of germinated barley, contains a large quantity of fermentable dietary fibers, especially hemicellulose. Ten grams of GBF were given to 10 healthy volunteers 3 times a day (30 g/day/person) for 28 consecutive days. Fecal weight, water contents and short chain fatty acid content were measured before GBF administration and from days 25 to 28 after initiation of GBF administration. GBF intake significantly increased fecal butyrate content as well as fecal weight and water content. No significant change in body weight resulted from consumption of GBF for 28 days. No major laboratory abnormalities were found in hematologic and urinary analysis. These findings indicate that GBF promotes defecation, produces bacterial short chain fatty acids, especially butyrate, without adverse effects, and is a safe foodstuff for humans.
authors.affiliation: Applied Bioresearch Center, Corporate Research and Development Division, Kirin Brewery Co. Ltd., Takasaki, Gunma 370-12, Japan.
authors.forename: O
authors.initials: O
authors.lastname: Kanauchi
authors.forename: K
authors.initials: K
authors.lastname: Mitsuyama
authors.forename: T
authors.initials: T
authors.lastname: Saiki
authors.forename: T
authors.initials: T
authors.lastname: Fushikia
authors.forename: T
authors.initials: T
authors.lastname: Iwanaga
mesh_terms: D000328:Adult; D001835:Body Weight / Q000187:drug effects; D002087:Butyrates / Q000378:metabolism*; D004043:Dietary Fiber / Q000008:administration & dosage*; D005243:Feces / Q000737:chemistry; D005260:Female; D018525:Germination; D001467:Hordeum / Q000737:chemistry* / Q000254:growth & development; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007958:Leukocyte Count / Q000187:drug effects; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood; D014867:Water / Q000378:metabolism
chemical_list: D002087:Butyrates; D004043:Dietary Fiber; D014867:Water; D012964:Sodium; D011188:Potassium