Short CAG repeats within the hSKCa3 gene associated with schizophrenia: results of a family-based study.
In a family-based association study we investigated transmission of a multiallelic CAG repeat in a novel neuronal potassium channel gene, hSKCa3, in 59 parent/ offspring trios. In contrast to recent reports of an association of moderately large repeats with schizophrenia in case-control studies, our findings indicate that short CAG repeats (< or=19 repeats) are transmitted at an increased frequency to schizophrenic offspring (p=0.014), particularly among familial cases (p=0.007). No evidence for a parent-of-origin effect was found. Multiallelic TDT procedure showed no association of individual CAG repeats to schizophrenia. Further studies using family-based designs should clarify whether hSKCa3 is a susceptibility factor to schizophrenia or co-segregates with a major disease gene in tight linkage.
Stöber
G
G
Department of Psychiatry, University of Würzburg, Germany.
Jatzke
S
S
Meyer
J
J
Okladnova
O
O
Knapp
M
M
Beckmann
H
H
Lesch
K P
KP
D000293:Adolescent; D000328:Adult; D000483:Alleles; D004252:DNA Mutational Analysis; D005192:Family Health; D005260:Female; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D008297:Male; D009479:Neuropeptides / Q000235:genetics*; D010375:Pedigree; D011110:Polymorphism, Genetic; D015221:Potassium Channels / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D051640:Small-Conductance Calcium-Activated Potassium Channels; D018911:Trinucleotide Repeats
C406328:KCNN3 protein, human; D009479:Neuropeptides; D015221:Potassium Channels; D051640:Small-Conductance Calcium-Activated Potassium Channels