[The anti-ulcer action of dibunol (Tonarol)].
In experimental study of antiulcerative activity of dibunol on various models of gastric ulcers in rats the drug caused a marked antiulcerative effect in all of them, reduced the incidence of ulcer formation, and shortened the time of ulcer healing. In a model of "acetic" ulcer dibunol oil solution led to quick normalization of lipid peroxidation in the gastric mucosa, which was evidence of high antioxidant activity in cases of ulcer lesions.
Zarudiĭ
R F
RF
Bashkir State Medical University, Institute of Organic Chemistry, Russian Academy of Sciences, Ufa, Russia.
Myshkin
V A
VA
Zarudiĭ
F S
FS
Ismagilova
A F
AF
Davydova
V A
VA
D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use*; D002084:Butylated Hydroxytoluene / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D051381:Rats; D013276:Stomach Ulcer / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D013997:Time Factors; D014810:Vitamin E / Q000627:therapeutic use; D014814:Vitamin U / Q000627:therapeutic use
D000897:Anti-Ulcer Agents; D000975:Antioxidants; D014810:Vitamin E; D002084:Butylated Hydroxytoluene; D014814:Vitamin U
Protivoiazvennoe deĭstvie dibunola (tonarola).