Preparation, characterization, and evaluation of physicochemical properties of different crystalline forms of ibuprofen.
Different crystal forms of ibuprofen (IBF) were prepared using methods such as cooling hot solution of the drug and precipitation of crystals from the drug solution. Scanning electron microscopy (SEM), differential scanning calorimetry (DSC), melting point, x-ray powder diffractometry, infrared absorption spectroscopy (IR), and in vitro dissolution rate and stability studies were conducted to investigate various characteristics of different crystalline forms of the drug. Methods of preparation and nature of the solvents used in this study were found to have greater roles in changing the physicochemical properties of IBF.
Khan
G M
GM
Zhong Kun Pharmaceutical Research Institute, School of Pharmacy, China Pharmaceutical University, Nanjing, People's Republic of China.
Jiabi
Z
Z
D002152:Calorimetry, Differential Scanning; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D003460:Crystallization; D004355:Drug Stability; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage / Q000737:chemistry* / Q000302:isolation & purification*; D066298:In Vitro Techniques; D008855:Microscopy, Electron, Scanning; D011208:Powders; D012996:Solutions; D012997:Solvents; D013055:Spectrophotometry, Infrared; D014961:X-Ray Diffraction
D011208:Powders; D012996:Solutions; D012997:Solvents; D007052:Ibuprofen