title: Targeted expression of teashirt induces ectopic eyes in Drosophila.
abstract: teashirt was initially identified as a gene required for the specification of the trunk segments in Drosophila embryogenesis and encodes a transcription factor with zinc finger motifs. We report here that targeted expression of teashirt in imaginal discs is sufficient to induce ectopic eye formation in non-eye tissues, a phenotype similar to that produced from targeted expression of eyeless, dachshund, and eyes absent. Furthermore, teashirt and eyeless induce the expression of each other, suggesting that teashirt is part of the gene network that functions to specify eye identity.
authors.affiliation: Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, CA 94720-3200, USA.
authors.forename: D
authors.initials: D
authors.lastname: Pan
authors.forename: G M
authors.initials: GM
authors.lastname: Rubin
mesh_terms: D000818:Animals; D002828:Choristoma / Q000235:genetics*; D003433:Crosses, Genetic; D004268:DNA-Binding Proteins / Q000235:genetics; D004330:Drosophila / Q000196:embryology / Q000235:genetics*; D029721:Drosophila Proteins; D004625:Embryo, Nonmammalian / Q000002:abnormalities / Q000502:physiology; D005124:Eye Abnormalities / Q000235:genetics*; D005136:Eye Proteins / Q000235:genetics; D005260:Female; D007301:Insect Hormones / Q000235:genetics; D008297:Male; D009687:Nuclear Proteins / Q000235:genetics; D012097:Repressor Proteins; D012160:Retina / Q000196:embryology; D014157:Transcription Factors / Q000235:genetics*; D014960:X Chromosome; D016335:Zinc Fingers
chemical_list: D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D005136:Eye Proteins; D007301:Insect Hormones; D009687:Nuclear Proteins; D012097:Repressor Proteins; D014157:Transcription Factors; C103968:dac protein, Drosophila; C113278:ey protein, Drosophila; C092694:eya protein, Drosophila; C066830:tsh protein, Drosophila