title: 8-(3-oxo-4,5,6-trihydroxy-3h-xanthen-9-yl)-1-naphthoic acid inhibits MAPK phosphorylation in endothelial cells induced by VEGF and bFGF.
abstract: Angiogenesis is regulated by various factors. In particular, VEGF and basic FGF are of much importance. We found that 8-(3-oxo-4,5,6-trihydroxy-3h-xanthen-9-yl)-1-naphthoic acid inhibited the binding of VEGF to KDR/Flk-1 (VEGF receptor-2) or Flt-1 (VEGF receptor-1) and that it inhibited the MAPK phosphorylation in HUVEC induced by VEGF or basic FGF but not by EGF. 8-(3-oxo-4,5,6-trihydroxy-3h-xanthen-9-yl)-1-naphthoic acid might be used as an inhibitor of VEGF and basic FGF signal transduction.
authors.affiliation: Life Science Research Center, Advanced Technology Research Laboratories, Nippon Steel Corporation, Nakahara-ku, Kawasaki 211-0035, Japan.
authors.initials: K
authors.lastname: Igarashi
authors.initials: T
authors.lastname: Isohara
authors.initials: T
authors.lastname: Kato
authors.initials: K
authors.lastname: Takigawa
authors.initials: K
authors.lastname: Shigeta
authors.initials: T
authors.lastname: Yamano
authors.initials: I
authors.lastname: Uno