[The pharmacokinetics and metabolism of heptapeptide--a prospective synthetic analog of tuftsin with psychostimulating action in rats].
The pharmacokinetics of a new heptapeptide with psychotropic activity was studied in rats in experiments in vitro and in vivo by means of high-performance liquid chromatography. The heptapeptide was detected in its natural form in rat blood plasma for 7-10 min; its T1/2 exceeded that of other oligopeptides of similar structure. The structure of the main pharmacologically active heptapeptide metabolite was identified by high performance liquid chromatography; it proved to be tetrapeptide Thr-Lys-Pro-Arg (taphtsin). The heptapeptide was distributed in well vascularized organs of rats: liver > kidneys > heart.
Boĭko
S S
SS
Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
Zherdev
V P
VP
Dvorianinov
A A
AA
Seredenin
S B
SB
Alfeeva
L Iu
LIu
Andreeva
L A
LA
Bezmenova
S V
SV
Miasoedov
N F
NF
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D006207:Half-Life; D011619:Psychotropic Drugs / Q000032:analysis / Q000493:pharmacokinetics*; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution; D014405:Tuftsin / Q000031:analogs & derivatives* / Q000032:analysis / Q000493:pharmacokinetics*
D011619:Psychotropic Drugs; D014405:Tuftsin
Farmakokinetika i metabolizm geptapeptida--perspektivnogo sinteticheskogo analoga taftsina s psikhostimuliruiushchim deĭstviem u krys.