A potent anti-diabetic agent from Kalopanax pictus.
To search for the anti-diabetic principle from the stem bark of Kalopanax pictus, seven kinds of chemical constituents including hedearagenin glycosides and phenolic glycosides were isolated. The anti-diabetic evaluation of these isolates in the streptozotocin-induced diabetic rats exhibited that kalopanaxsaponin A has a potent anti-diabetic activity in contrast to a mild activity of hedearagenin. In addition, significant hypocholesterolemic and hypolipidemic activities of kalopanaxsaponin A and hedearagenin were observed. The structure-activity relationship of kalopanaxsaponin A was also investigated in the present work.
Park
H J
HJ
Department of Botanical Resources, Sangji University, Wonju, Seoul.
Kim
D H
DH
Choi
J W
JW
Park
J H
JH
Han
Y N
YN
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D008074:Lipoproteins / Q000097:blood; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D019441:Plant Epidermis / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D008076:Cholesterol, HDL; D007004:Hypoglycemic Agents; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol