title: [Prolonged epidural analgesia induced by clopheline in combination with lidocaine in obstetric analgesia].
abstract: The study was carried out in 178 women without grave obstetrical or extragenital diseases. In group 1 labor pain was relieved by prolonged epidural anesthesia with 2% lidocaine solution (2-2.5 mg/kg), in group 2 prolonged epidural anesthesia with 1% lidocaine solution (1 mg/kg) and 0.01% clofelin (1 microgram/kg) was administered. Central hemodynamics, heart rhythm, external respiration function, uterine contractility, and fetal intrauterine status were assessed. The findings indicate that none of the methods had a negative impact on the vital parameters of women and newborns at any stage of anesthesia. However, a combination of epidural clofelin (1 microgram/kg) with lidocaine permits an appreciable decrease in the doses of both drugs without decreasing the efficacy of anesthesia. This method has a favorable effect on the course of labor: the mouth of the womb opens sooner at a lower uterine activity and there are no negative effects on the fetus and newborn.
authors.forename: A A
authors.initials: AA
authors.lastname: Semenikhin
authors.lastname: En Din Kim
authors.forename: S D
authors.initials: SD
authors.lastname: Kurbanov
mesh_terms: D000293:Adolescent; D000328:Adult; D015360:Analgesia, Epidural; D016362:Analgesia, Obstetrical; D000700:Analgesics / Q000008:administration & dosage*; D000779:Anesthetics, Local / Q000008:administration & dosage*; D003000:Clonidine / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005069:Evaluation Studies as Topic; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007231:Infant, Newborn; D008012:Lidocaine / Q000008:administration & dosage*; D012119:Respiration; D013997:Time Factors
chemical_list: D000700:Analgesics; D000779:Anesthetics, Local; D008012:Lidocaine; D003000:Clonidine
vernacular_title: Dlitel'naia épidural'naia analgeziia klofelinom v sochetanii s lidokainom pri obezbolivanii rodov.