title: Application of tissue adhesives: rapid attainment of proficiency. Stony Brook Octylcyanoacrylate Study Group.
abstract: OBJECTIVE
  To evaluate the 3-month cosmetic outcome following laceration repair with a new tissue adhesive, 2-octylcyanoacrylate, as a function of physician experience with this tissue adhesive.
  
  
  METHODS
  The authors prospectively enrolled consecutive patients >1 year of age with non-bite, non-crush-induced lacerations who presented <6 hours after injury and were treated with 2-octylcyanoacrylate. Structured closed-question data sheets were completed at the time of laceration repair and at 3-month follow-up. Long-term cosmetic appearance (>3 months) was assessed by patients using a 100-mm visual analog scale. The cosmetic outcomes were evaluated as a function of the physician application using ANOVA or chi2 tests, as appropriate. This study had 80% power to detect a 10-mm difference between the 2-octylcyanoacrylate and suture groups (alpha, 0.05).
  
  
  RESULTS
  Seven physicians applied 2-octylcyanoacrylate to 63 patients; 61 patients received sutures. Patients were similar in the 2 groups (age, gender, race, history, and wound characteristics; p > 0.05 for all). At long-term follow-up, the cosmetic outcomes were similar in the 2-octylcyanoacrylate and suture groups according to patients (VAS 83.8 +/- 19.4 mm vs 82.5 +/- 17.6 mm; p = 0.72) and physicians (optimal score, 77% vs 80%; p = 0.67), and independent of physician experience with the 2-octylcyanoacrylate. One wound developed an infection and one wound necessitated reclosure due to dehiscence. Neither occurred with the first application.
  
  
  CONCLUSIONS
  The 3-month cosmetic appearance of wounds treated with 2-octylcyanoacrylate is equivalent to that with sutures and does not improve as physicians become more experienced with use of this tissue adhesive. These data suggest that physicians can develop competence in application of tissue adhesives with a brief training period.
authors.affiliation: Department of Emergency Medicine, Hospital of the University of Pennsylvania, Philadelphia 19104-4283, USA. jholland@mail.med.upenn.edu
authors.forename: J E
authors.initials: JE
authors.lastname: Hollander
authors.forename: A J
authors.initials: AJ
authors.lastname: Singer
mesh_terms: D002983:Clinical Competence; D003487:Cyanoacrylates; D004632:Emergency Medical Services; D004954:Esthetics; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D011446:Prospective Studies; D013536:Suture Techniques; D013537:Sutures; D014014:Tissue Adhesives; D014945:Wound Healing; D014950:Wounds, Penetrating / Q000628:therapy
chemical_list: D003487:Cyanoacrylates; D014014:Tissue Adhesives