title: Evaluation of hydrogel-based controlled-release niacin tablets.
abstract: Matrix-based controlled-release niacin tablets were formulated using guar gum. The effect on the in vitro dissolution profile was examined using variable guar gum content in the formulation. It was observed that the dissolution profile declined with the increase in the guar gum content in the tablet. The in vitro dissolution profile was also observed under different pH conditions and there was no marked change. The moisture content of granules also did not cause any considerable change in dissolution profile. Three different strength Niacin controlled-release tablets, including 500 mg, were prepared and it was found that applying the same variables of different guar gum content and moisture content of granules resulted in a very insignificant change in the in vitro dissolution profile. The experimental formulation compared well with commercial products and met the proposed standards for controlled-release products.
authors.affiliation: Dabur Research Foundation, Ghaziabad, India.
authors.forename: P
authors.initials: P
authors.lastname: Khullar
authors.forename: R K
authors.initials: RK
authors.lastname: Khar
authors.forename: S P
authors.initials: SP
authors.lastname: Agarwal
mesh_terms: D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004355:Drug Stability; D005685:Galactans; D006801:Humans; D020100:Hydrogels; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008351:Mannans; D009525:Niacin / Q000008:administration & dosage* / Q000737:chemistry; D014677:Pharmaceutical Vehicles; D053149:Plant Gums; D013607:Tablets; D014783:Viscosity; D014867:Water
chemical_list: D003692:Delayed-Action Preparations; D005685:Galactans; D020100:Hydrogels; D008351:Mannans; D014677:Pharmaceutical Vehicles; D053149:Plant Gums; D013607:Tablets; D014867:Water; D009525:Niacin; C007894:guar gum