Caged compounds of a 2-deoxyglucose: facile synthesis and their photoreactivity.
An o-nitrobenzyl and an o-nitrophenethyl derivatized 2-deoxyglucose (caged 2-deoxyglucoses) were synthesized from 3,4,6-tri-O-acetyl-D-glucal in only two steps in moderate to good yields as isomeric mixtures, which were irradiated at 350 nm to afford a 2-deoxyglucose. Decomposition of the o-nitrophenethyl derivative upon photolysis proceeded more efficiently than that of the o-nitrobenzyl derivative.
Watanabe
S
S
Department of Biomolecular Science, Faculty of Science, Toho University, Chiba, Japan.
Hirokawa
R
R
Iwamura
M
M
D003847:Deoxyglucose / Q000138:chemical synthesis* / Q000737:chemistry; D004355:Drug Stability; D009682:Magnetic Resonance Spectroscopy; D010777:Photochemistry
D003847:Deoxyglucose