Insulin-like growth factor-1 and insulin-like growth factor-binding protein-3 in women with premenstrual syndrome.
OBJECTIVE
To determine whether women with premenstrual syndrome (PMS) have aberrations of the GH axis as has been demonstrated in individuals with depression.


METHODS
Prospective trial.


METHODS
Department of Obstetrics and Gynecology, University of California, Los Angeles.


METHODS
After prospective screening, 32 healthy women with PMS and 32 asymptomatic controls completed the study.


METHODS
Subjects completed a daily PMS symptom diary and a Beck Depression Inventory. They underwent phlebotomy 5 days and 12 days after the LH midcycle surge, which was identified with the use of a urinary LH detection kit.


METHODS
Serum levels of insulin-like growth factor-1 (IGF-1), insulin-like growth factor-binding protein-3 (IGFBP-3), E2, and progesterone.


RESULTS
Levels of IGF-1, IGFBP-3, E2, and progesterone did not differ between women with prospectively documented PMS and control subjects.


CONCLUSIONS
Premenstrual syndrome and affective disorder share common symptoms and possibly a common cause. Biochemical markers such as alterations in the somatotropic system often are associated with major depression. Levels of IGF-1 and IGFBP-3 did not differ between women with PMS and control subjects, supporting the concept that PMS and endogenous depression are biologically distinct entities.
Rapkin
A J
AJ
University of California, Los Angeles Medical Center, Department of Obstetrics and Gynecology, 90095-1740, USA.
Cedars
M
M
Morgan
M
M
Goldman
L
L
D000328:Adult; D016022:Case-Control Studies; D003863:Depression / Q000097:blood* / Q000209:etiology; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D011293:Premenstrual Syndrome / Q000097:blood* / Q000523:psychology; D011374:Progesterone / Q000097:blood
D018972:Insulin-Like Growth Factor Binding Protein 3; D011374:Progesterone; D004958:Estradiol; D007334:Insulin-Like Growth Factor I