Clinical pharmacology and therapeutic drug monitoring in neonates and children.
From a pharmacotherapy perspective, the process of development and growth represents an unstable and dynamic condition. Age-related changes in drug absorption, distribution, and metabolism among neonates, infants, and prepubescent children create a unique situation that may increase drug toxicity of some agents and protect from toxicity of other agents. Understanding the age-related changes in drug disposition that are relevant for therapeutic response and toxicity is essential for optimizing pharmacotherapy at different stages of childhood.
Loebstein
R
R
Department of Pediatrics and Population Health Sciences, Research Institute, Hospital for Sick Children, University of Toronto, Ontario, Canada.
Koren
G
G
D000042:Absorption; D001682:Biological Availability; D002648:Child; D004347:Drug Interactions; D016903:Drug Monitoring; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007668:Kidney / Q000378:metabolism; D007774:Lactation; D008099:Liver / Q000378:metabolism; D008895:Milk, Human / Q000378:metabolism; D010599:Pharmacokinetics