title: Assortative mating for major psychiatric diagnoses in two population-based samples.
abstract: BACKGROUND
  Previous studies on assortment for psychiatric disorders have reported discrepant findings. We aimed to test whether there is a significant association for psychiatric diagnoses, including alcoholism, generalized anxiety disorder, major depressive disorder, panic disorder and phobias between husbands and wives in two population-based samples. We further evaluated whether marital resemblance occurs primarily within or across psychiatric disorders and if assortment for psychopathology is primary or secondary to assortment for correlated variables.
  
  
  METHODS
  A model for mate selection addressed whether the correlation between mates for psychiatric disorders arises from direct assortment (primary homogamy) or through correlation with other variables for which assortment occurs (secondary homogamy) or through cross-variable assortment. The model accounted for within-person co-morbidity as well as across-spouse data.
  
  
  RESULTS
  Findings suggested that a moderate degree of assortment exists both within and across psychiatric diagnoses. Only a small amount of the observed marital resemblance for mental illness could be explained by assortment for correlated variables such as age, religious attendance and education. Similar results were obtained for the two samples separately and confirmed in their joint analysis, revealing that the co-morbidity and assortment findings, except for the marital correlation for age, religious attendance and education, replicate across samples.
  
  
  CONCLUSIONS
  Significant but moderate primary assortment exists for psychiatric disorders. The bias in twin studies that have ignored the small amount of assortment is negligible.
authors.affiliation: Department of Human Genetics, Virginia Commonwealth University, Richmond 23298-0003, USA.
authors.forename: H H
authors.initials: HH
authors.lastname: Maes
authors.forename: M C
authors.initials: MC
authors.lastname: Neale
authors.forename: K S
authors.initials: KS
authors.lastname: Kendler
authors.forename: J K
authors.initials: JK
authors.lastname: Hewitt
authors.forename: J L
authors.initials: JL
authors.lastname: Silberg
authors.forename: D L
authors.initials: DL
authors.lastname: Foley
authors.forename: J M
authors.initials: JM
authors.lastname: Meyer
authors.forename: M
authors.initials: M
authors.lastname: Rutter
authors.forename: E
authors.initials: E
authors.lastname: Simonoff
authors.forename: A
authors.initials: A
authors.lastname: Pickles
authors.forename: L J
authors.initials: LJ
authors.lastname: Eaves
mesh_terms: D000293:Adolescent; D000328:Adult; D000437:Alcoholism / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D001008:Anxiety Disorders / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D015897:Comorbidity; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008393:Marriage; D001523:Mental Disorders / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D008875:Middle Aged; D008957:Models, Genetic; D012931:Social Environment; D018454:Spouses / Q000523:psychology*