title: An approach to switching patients from baclofen to tizanidine.
abstract: With the introduction of the antispasticity agent, tizanidine hydrochloride (Zanaflex), physicians have requested information about the optimal way to switch appropriate patients from baclofen to tizanidine. A group of neurologists and rehabilitation specialists with a particular interest in spasticity was therefore asked to draw up a suitable approach to changing treatment.
authors.affiliation: Department of Neurology, Royal Free Hospital, London.
authors.forename: R
authors.initials: R
authors.lastname: Brenner
authors.forename: N
authors.initials: N
authors.lastname: Hyman
authors.forename: R
authors.initials: R
authors.lastname: Knobler
authors.forename: M
authors.initials: M
authors.lastname: O'Brien
authors.forename: T
authors.initials: T
authors.lastname: Stephan
mesh_terms: D001418:Baclofen / Q000009:adverse effects / Q000627:therapeutic use*; D002983:Clinical Competence; D003000:Clonidine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D009103:Multiple Sclerosis / Q000150:complications; D009125:Muscle Relaxants, Central / Q000009:adverse effects / Q000627:therapeutic use*; D009128:Muscle Spasticity / Q000188:drug therapy* / Q000209:etiology; D013118:Spinal Cord Diseases / Q000188:drug therapy; D013119:Spinal Cord Injuries / Q000188:drug therapy
chemical_list: D009125:Muscle Relaxants, Central; C023754:tizanidine; D001418:Baclofen; D003000:Clonidine