title: Comparison of relapse and long-term survival between pylorus-preserving and Whipple pancreaticoduodenectomy in periampullary cancer.
abstract: BACKGROUND
  Whether long-term survival and type of recurrence in periampullary cancer are influenced by the type of surgical procedure or not is still obscure. The purpose of this review was to analyze the results at a single institution.
  
  
  METHODS
  Between 1982 and 1996, 113 consecutive patients with either distal bile duct or ampullary cancers underwent either pylorus-preserving pancreaticoduodenectomy (PPPD) or the Whipple procedure. The median follow-up was 30 months (range 12 to 150). Patient records were reviewed to determine type of recurrence and survival.
  
  
  RESULTS
  In distal bile duct or ampullary cancers, comparison of actuarial survival curves between PPPD and the Whipple operation revealed no significant differences. Even in node-positive patients, the 5-year survival rates did not differ significantly between those undergoing PPPD or the Whipple operation. Tumor recurrence was not correlated with the operative method, although among types of tumor recurrence, the rate of blood-borne metastasis was higher in distal bile duct or ampullary cancers.
  
  
  CONCLUSIONS
  PPPD is an acceptable alternative to the Whipple procedure in the treatment of periampullary cancer. Long-term survival and type of recurrence were not influenced by these types of surgical procedures.
authors.affiliation: First Department of Surgery, Kagoshima University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Takao
authors.forename: T
authors.initials: T
authors.lastname: Aikou
authors.forename: H
authors.initials: H
authors.lastname: Shinchi
authors.forename: K
authors.initials: K
authors.lastname: Uchikura
authors.forename: M
authors.initials: M
authors.lastname: Kubo
authors.forename: H
authors.initials: H
authors.lastname: Imamura
authors.forename: S
authors.initials: S
authors.lastname: Maenohara
mesh_terms: D000328:Adult; D000368:Aged; D014670:Ampulla of Vater / Q000473:pathology / Q000601:surgery*; D001650:Bile Duct Neoplasms / Q000601:surgery*; D003138:Common Bile Duct Neoplasms / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D016577:Pancreaticoduodenectomy; D011708:Pylorus / Q000601:surgery; D012189:Retrospective Studies; D016019:Survival Analysis