Identification of N2-(1-carboxymethyl)guanine (CMG) as a guanine advanced glycation end product.
The reaction of D-glucose with 9-methylguanine produces N2-fructosyl-9-methylguanine, which undergoes oxidation to produce N2-(1-carboxymethyl)-9-methylguanine as a major adduct.
al-Abed
Y
Y
Picower Institute for Medical Research, Manhasset, NY 11030, USA.
Schleicher
E
E
Voelter
W
W
Liebich
H
H
Papoulis
A
A
Bucala
R
R
D005947:Glucose / Q000737:chemistry*; D017127:Glycation End Products, Advanced / Q000032:analysis / Q000737:chemistry*; D006147:Guanine / Q000031:analogs & derivatives* / Q000737:chemistry; D007202:Indicators and Reagents; D015394:Molecular Structure; D010084:Oxidation-Reduction
D017127:Glycation End Products, Advanced; D007202:Indicators and Reagents; C116702:N(2)-(1-carboxymethyl)guanine; C116701:9-methylguanine; D006147:Guanine; D005947:Glucose