title: Screening and isolation of antibiotic resistance inhibitors from herb materials IV-resistance inhibitors from Anetheum graveolens and Acorus gramineus.
abstract: The hexane fractions from methanolic extracts of Anetheum graveolens L. (Umbelliferae) and Acorus gramineus Soland. (Araceae), revealed potent inhibitory activities against the resistance of multi-drug resistant Staphylococcus aureus SA2 when combined with ampicillin (Am) or chloramphenicol (Cm). As active principles, carvone and the liquid mixture containing carvone from Anetheum graveolens L. and a liquid mixture mainly consisting of benzoic acid phenylmethyl ester (benzyl benzoate) from Acorus gramineus Soland, were identified. They showed resistance inhibition at the level of 20-50 micrograms/ml when combined with 100 or 50 micrograms/ml of Am or Cm, respectively.
authors.affiliation: College of Pharmacy, Kyungsung University, Pusan, Korea.
authors.forename: H
authors.initials: H
authors.lastname: Kim
authors.forename: K H
authors.initials: KH
authors.lastname: Moon
authors.forename: S Y
authors.initials: SY
authors.lastname: Ryu
authors.forename: D C
authors.initials: DC
authors.lastname: Moon
authors.forename: C K
authors.initials: CK
authors.lastname: Lee
mesh_terms: D000667:Ampicillin / Q000494:pharmacology; D000668:Ampicillin Resistance; D019661:Apiaceae / Q000737:chemistry*; D001565:Benzoates / Q000494:pharmacology; D002478:Cells, Cultured; D002701:Chloramphenicol / Q000494:pharmacology; D002702:Chloramphenicol Resistance; D000081005:Cyclohexane Monoterpenes; D004352:Drug Resistance, Microbial; D019684:Magnoliopsida / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D039821:Monoterpenes; D013211:Staphylococcus aureus / Q000187:drug effects; D013729:Terpenes / Q000494:pharmacology
chemical_list: D001565:Benzoates; D000081005:Cyclohexane Monoterpenes; D039821:Monoterpenes; D013729:Terpenes; D002701:Chloramphenicol; C006923:carvone; D000667:Ampicillin; C006723:benzyl benzoate