Preparation and characterization of oil-in-water type poly (D,L-lactic acid) microspheres containing testosterone enanthate.
Poly (D,L-lactic acid) (PLA) microspheres containing testosterone enanthate (ET) were prepared by using an oil-in-water (O/W) emulsion technique. The size distribution of the microspheres obtained could be explained by a log-normal distribution, and as a result, it was found that ET fully incorporates into microspheres even when the drug is loaded at up to 50%. On the other hand, the dissolution behavior of ET from microspheres was strongly dependent on particle size, suggesting that dissolution of the drug from microspheres can be easily controlled by controlling the preparative conditions.
Tsubuku
S
S
Central Research Laboratories, Zeria Pharmaceutical Co., Ltd., Saitama, Japan.
Sugawara
S
S
Miyajima
M
M
Yoshida
M
M
Asano
M
M
Okabe
K
K
Kobayashi
D
D
Yamanaka
H
H
D002152:Calorimetry, Differential Scanning; D003272:Contraceptive Agents, Male / Q000493:pharmacokinetics*; D016503:Drug Delivery Systems; D004655:Emulsions; D019344:Lactic Acid; D008863:Microspheres; D010316:Particle Size; D011091:Polyesters; D011108:Polymers; D011142:Polyvinyl Alcohol; D012995:Solubility; D013739:Testosterone / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
D003272:Contraceptive Agents, Male; D004655:Emulsions; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; D013739:Testosterone; C033616:poly(lactide); C004648:testosterone enanthate; D011142:Polyvinyl Alcohol