Germinated barley foodstuff increases fecal volume and butyrate production at relatively low doses and relieves constipation in humans.
Germinated barley foodstuff (GBF), derived from the aleurone layer, scutellum and germ of germinated barley, contains a large quantity of fermentable dietary fibers, especially hemicellulose. GBF was given to 9 healthy volunteers in a dose of 9 g of GBF per day for 10 consecutive days, and subsequently 18 g of GBF for another 10 days. As a control, no GBF was given for 3 days before administration of GBF (control period). Fecal weight, water content and short chain fatty acid content were measured before and during the last 3 days of each experimental period. Feeding of GBF significantly increased the fecal butyrate content as well as fecal weight at both dose-levels (9 and 18 g/day), compared with those during the control period. Daily administration of 9 g GBF induced the maximum level of defecation in humans. Relatively mild but chronic constipated volunteers (n = 16) were administered 9 g of GBF daily for 14 days. In this experiment, the condition of defecation (frequency, volume) was estimated by a questionnaire survey. GBF significantly improved defecation within a short period without severe adverse effects. No major abnormalities in laboratory findings were found in hematologic and urinary analyses. In conclusion, daily administration of 9 g GBF was effective for improving defecation in healthy but constipated humans. GBF is a highly safe and effective foodstuff for improving defecation.
Kanauchi
O
O
Applied Bioresearch Center, Corporate Research and Development Division Kirin Brewery Co. Ltd., Miyaharacho 3, Takasaki, Gunma 370-1295, Japan.
Mitsuyama
K
K
Saiki
T
T
Nakamura
T
T
Hitomi
Y
Y
Bamba
T
T
Araki
Y
Y
Fujiyama
Y
Y
D000328:Adult; D002087:Butyrates / Q000032:analysis*; D003248:Constipation / Q000503:physiopathology / Q000517:prevention & control*; D003672:Defecation; D004043:Dietary Fiber / Q000008:administration & dosage; D005243:Feces / Q000737:chemistry*; D005260:Female; D018525:Germination; D001467:Hordeum; D006801:Humans; D008297:Male
D002087:Butyrates; D004043:Dietary Fiber