Radically novel prostaglandins in animals and plants: the isoprostanes.
Animal prostaglandins and plant jasmonates are well-known enzymatically formed cyclopentanoic lipids that have regulatory functions and serve as inducible mediators of host defense reactions. A novel group of prostaglandin-like compounds, the isoprostanes, generated in animals and plants by a nonenzymatic, free radical-catalyzed process, are now suspected to be mediators of oxidant injury in vivo.
Mueller
M J
MJ
Institute of Pharmacy, University of Munich, Karlstrasse 29 D-80333, Munich, Germany. Martin.Mueller@lrz.uni-muenchen.de
D000818:Animals; D002384:Catalysis; D003517:Cyclopentanes; D005609:Free Radicals; D008956:Models, Chemical; D018384:Oxidative Stress; D054883:Oxylipins; D010937:Plant Growth Regulators / Q000502:physiology*; D010944:Plants; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D011453:Prostaglandins / Q000502:physiology*; D021382:Protein Sorting Signals
D003517:Cyclopentanes; D005609:Free Radicals; D054883:Oxylipins; D010937:Plant Growth Regulators; D011453:Prostaglandins; D021382:Protein Sorting Signals; C011006:jasmonic acid; D011451:Prostaglandin-Endoperoxide Synthases