title: Lymphoproliferative disorders after renal transplantation: role of medical imaging.
abstract: Post-transplantation lymphoproliferative disorders (PTLD) are a complication of immunosuppressed transplant recipients, and their incidence is reported to be 20-120 times greater than the rate in the general population. After kidney transplantation, PTLD more likely arise within the renal transplant fossa. Radiological patterns of these forms are presented and discussed, according to a review of the literature, and illustrated by cases from our institution. Ultrasound plays an essential role in the early diagnosis of PTLD by detecting a urinary obstruction associated with adenopathy or an ill-defined mass not previously seen. However, in the case of an inconclusive US examination, CT or MRI should be performed to confirm the presence of a mass. Both techniques are useful in evaluating the extension of the process within the transplantation fossa; MRI seems more accurate and can be used for the follow-up, especially after reduction in immunosuppressive therapy without transplant removal.
authors.affiliation: Service de Radiologie, Hôpital de Brabois, Vandoeuvre les Nancy, France.
authors.forename: M
authors.initials: M
authors.lastname: Claudon
authors.forename: M
authors.initials: M
authors.lastname: Kessler
authors.forename: J
authors.initials: J
authors.lastname: Champigneulle
authors.forename: F
authors.initials: F
authors.lastname: Lefevre
authors.forename: D
authors.initials: D
authors.lastname: Hestin
authors.forename: E
authors.initials: E
authors.lastname: Renoult
mesh_terms: D001706:Biopsy; D003952:Diagnostic Imaging; D005500:Follow-Up Studies; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D007166:Immunosuppressive Agents / Q000009:adverse effects; D015994:Incidence; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000000981:diagnostic imaging; D008232:Lymphoproliferative Disorders / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography; D014555:Urination Disorders / Q000000981:diagnostic imaging
chemical_list: D007166:Immunosuppressive Agents