Requirement of the glycosyl parts in platycodin D to stimulate pancreatic exocrine secretion.
The whole structure of platycodin D is found to be essential to stimulate the volumetric increase in the pancreatic exocrine secretion, while the prosapogenins prepared from platycodin D increased only protein output of pancreatic juice.
Ida
Y
Y
School of Pharmaceutical Sciences, Showa University, Tokyo, Japan. ida@pharm.showa-u.ac.jp
Hirai
Y
Y
Kajimoto
T
T
Shingu
K
K
Miura
T
T
Kuwahara
N
N
Taguchi
S
S
Sasaki
K
K
Kuroiwa
Y
Y
Yamamoto
T
T
Arai
I
I
Amagaya
S
S
Komatsu
Y
Y
D000818:Animals; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D018517:Plant Roots; D010946:Plants, Medicinal; D051381:Rats; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014315:Triterpenes
D012503:Saponins; D014315:Triterpenes; C108953:platycodin D