title: Complications of subcutaneous low-dose heparin therapy in neurosurgical patients.
abstract: BACKGROUND
  Venous thromboembolism is a major cause of postoperative morbidity and mortality in neurosurgery. The use of low-dose unfractionated heparin therapy perioperatively for prophylaxis against deep vein thromboses and pulmonary embolism has been well demonstrated in many other surgical specialties but is less commonly used in neurosurgery because of fears of devastating postoperative hematomas.
  
  
  METHODS
  The safety of such therapy has been analyzed in 950 patients undergoing an inpatient neurosurgical procedure. 872 patients (152 cranial procedures) completed treatment with 5000 U sodium heparin subcutaneously twice a day, commencing before surgery and continuing till patients were ambulatory.
  
  
  RESULTS
  There were three minor hemorrhagic complications-two superficial wound hematomas (one requiring treatment) and one gastrointestinal hemorrhage-identified. Three clinically significant major complications developed, two epidural hematomas after spinal surgery requiring evacuation and one intraventricular hemorrhage after brain biopsy.
  
  
  CONCLUSIONS
  This report, along with an analysis of previously published reports of low-dose perioperative heparin therapy in neurosurgical patients, suggests that such therapy is unlikely to be associated with increased morbidity. Given the known efficacy of low-dose heparin in reducing venous thromboembolism in other surgical patients, such therapy may reduce mortality and morbidity from thromboembolic complications in neurosurgical patients with minimal risk.
authors.affiliation: Neurosurgical Service, Veterans Affairs Medical Center, Minneapolis, Minnesota, USA.
authors.forename: D Y
authors.initials: DY
authors.lastname: Wen
authors.forename: W A
authors.initials: WA
authors.lastname: Hall
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects*; D004334:Drug Administration Schedule; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced; D006407:Hematoma, Epidural, Cranial / Q000139:chemically induced; D006470:Hemorrhage / Q000139:chemically induced*; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects*; D006784:Hospitals, Teaching; D006801:Humans; D007279:Injections, Subcutaneous; D019635:Neurosurgical Procedures / Q000009:adverse effects*; D011446:Prospective Studies; D020246:Venous Thrombosis / Q000209:etiology / Q000517:prevention & control*
chemical_list: D000925:Anticoagulants; D006493:Heparin