The implications of hyperhomocysteinemia in a patient with type 1 diabetes.
We present a patient with type 1 diabetes mellitus, who had severe, progressive macrovascular disease despite an optimal control of modifiable risk factors. Screening for other risk factors revealed a markedly elevated plasma homocysteine level, that was secondary to pernicious anemia. The biological and clinical implications of this association are discussed.
van Leeuwen-Wintjens
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Afdeling Endocrinologie, Metabolisme en Voeding, Universitair Ziekenhuis Gasthuisberg, Leuven, Belgium.
Muls
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D000752:Anemia, Pernicious / Q000150:complications; D001161:Arteriosclerosis / Q000209:etiology*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000517:prevention & control; D005757:Gastritis, Atrophic / Q000209:etiology; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014804:Vitamin B Deficiency / Q000209:etiology