Applications of Raman spectroscopy to ophthalmology: spectroscopic characterization of disposable soft contact lenses.
Disposable soft contact lenses based on HEMA-MAA hydrogels are examined using Raman and ATR/FTIR vibrational spectroscopies and thermal analysis. The main factors dealing with physical, chemical, and biological biocompatibility are evaluated in relation to those of long-wear soft contact lenses with the aim of individuating the most biocompatible lens. The Raman spectra of HEMA-MAA lenses show that some biocompatibility factors are affected by environmental conditions and, in particular, by changes in pH and ionic strength values.
Monti
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Centro di Studio sulla Spettroscopia Raman, Dipartimento di Biochimica G. Moruzzi, Università di Bologna, Italy.
Simoni
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Caramazza
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Bertoluzza
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A
D001672:Biocompatible Materials / Q000737:chemistry*; D002021:Buffers; D018639:Contact Lens Solutions; D003263:Contact Lenses, Hydrophilic; D004055:Differential Thermal Analysis; D004209:Disposable Equipment; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009994:Osmolar Concentration; D012965:Sodium Chloride; D013055:Spectrophotometry, Infrared; D013059:Spectrum Analysis, Raman / Q000379:methods*; D013997:Time Factors; D014867:Water
D001672:Biocompatible Materials; D002021:Buffers; D018639:Contact Lens Solutions; D014867:Water; D012965:Sodium Chloride