The first conversion of camptothecin to (S)-mappicine by an efficient chemoenzymatic method.
Camptothecin has been converted for the first time to (S)-mappicine via mappicine ketone, which is the sole product of the microwave irradiation of camptothecin. Baker's yeast reduction of mappicine ketone yielded (S)-mappicine in high optical purity.
Das
B
B
Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad, India.
Madhusudhan
P
P
Kashinatham
A
A
D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D002166:Camptothecin / Q000737:chemistry* / Q000528:radiation effects; D008872:Microwaves; D012441:Saccharomyces cerevisiae / Q000201:enzymology; D013237:Stereoisomerism
D000470:Alkaloids; C008325:mappicine; D002166:Camptothecin