title: Discovery of an imidazopyridine-containing 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonist with efficacy in a restenosis model.
abstract: In the 3-oxo-1,4-benzodiazepine-2-acetic acid series of vitronectin receptor (alpha v beta 3) antagonists, a compound containing an imidazopyridine arginine mimetic was discovered which had sufficient potency and i.v. pharmacokinetics for demonstration of efficacy in a rat restenosis model.
authors.affiliation: Research & Development Division, SmithKline Beecham Pharmaceuticals, Collegeville, PA 19426-0989, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Keenan
authors.forename: M A
authors.initials: MA
authors.lastname: Lago
authors.forename: W H
authors.initials: WH
authors.lastname: Miller
authors.forename: F E
authors.initials: FE
authors.lastname: Ali
authors.forename: R D
authors.initials: RD
authors.lastname: Cousins
authors.forename: L B
authors.initials: LB
authors.lastname: Hall
authors.forename: S M
authors.initials: SM
authors.lastname: Hwang
authors.forename: D R
authors.initials: DR
authors.lastname: Jakas
authors.forename: C
authors.initials: C
authors.lastname: Kwon
authors.forename: C
authors.initials: C
authors.lastname: Louden
authors.forename: T T
authors.initials: TT
authors.lastname: Nguyen
authors.forename: E H
authors.initials: EH
authors.lastname: Ohlstein
authors.forename: D J
authors.initials: DJ
authors.lastname: Rieman
authors.forename: S T
authors.initials: ST
authors.lastname: Ross
authors.forename: J M
authors.initials: JM
authors.lastname: Samanen
authors.forename: B R
authors.initials: BR
authors.lastname: Smith
authors.forename: J
authors.initials: J
authors.lastname: Stadel
authors.forename: D T
authors.initials: DT
authors.lastname: Takata
authors.forename: L
authors.initials: L
authors.lastname: Vickery
authors.forename: C C
authors.initials: CC
authors.lastname: Yuan
authors.forename: T L
authors.initials: TL
authors.lastname: Yue
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects*; D000818:Animals; D001569:Benzodiazepines / Q000627:therapeutic use*; D003327:Coronary Disease / Q000188:drug therapy*; D004195:Disease Models, Animal; D007093:Imidazoles / Q000627:therapeutic use*; D011725:Pyridines / Q000627:therapeutic use*; D051381:Rats; D019030:Receptors, Vitronectin / Q000037:antagonists & inhibitors*
chemical_list: D007093:Imidazoles; D011725:Pyridines; D019030:Receptors, Vitronectin; D001569:Benzodiazepines