[The dependence of thrombocyte aggregation on temperature].
The effect of temperature (range of 4-44 degrees C) upon induced aggregation of platelets from normal subjects was studied. It was shown that temperature dependences of aggregation degree and rate have maxima. A relationship between aggregation agonist kind and some features of the temperature dependence curve of the aggregation parameters is established. It was shown that the limitation of platelet membrane lipids mobility by means of lipids peroxidation leads to the shift of maxima of the temperature dependence curve of platelet aggregation degree and rate. It was concluded that character of aggregation temperature dependence was governed by phase transition in platelet membrane lipids at room temperature.
Berest
V P
VP
State University, Ministry of Education of Ukraine, Kharkiv.
Hatash
S V
SV
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects / Q000502:physiology*; D012016:Reference Values; D012310:Ristocetin / Q000494:pharmacology; D013696:Temperature
D000900:Anti-Bacterial Agents; D012310:Ristocetin; D000244:Adenosine Diphosphate; D006861:Hydrogen Peroxide; D004837:Epinephrine
Zalezhnist' ahrehatsiï trombotsytiv vid temperatury.