[Delirium during oral therapy of herpes zoster with acyclovir. Case report and brief review of central nervous system side-effects of acyclovir].
In differential diagnosis of a delir also adverse effects of medicaments have to be taken into account beside other causes. We report a case of an agitated delir with nocturnal disturbance of consciousness, confusion, restlessness and sleeplessness. This delir existed exclusively during the therapy of a cutaneous herpes zoster with zovirax-pills which can only be explained by a causal connection--after exclusion of other causes. As a so far undescribed predisposition for neurotoxicity of oral therapy with acyclovir signs of vascular encephalopathy were found in the patient's cranial magnetic resonance imaging. The central nervous side effects of acyclovir were summarized shortly.
Braun
J S
JS
Abteilung für Psychiatrie und Psychotherapie, Albert-Ludwigs-Universität, Freiburg.
Apel
I
I
Schäffer
S
S
Schumacher
M
M
Berger
M
M
D000212:Acyclovir / Q000009:adverse effects* / Q000627:therapeutic use; D000368:Aged; D000998:Antiviral Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000473:pathology; D003693:Delirium / Q000139:chemically induced* / Q000175:diagnosis; D015140:Dementia, Vascular / Q000175:diagnosis; D003937:Diagnosis, Differential; D006562:Herpes Zoster / Q000188:drug therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011605:Psychoses, Substance-Induced / Q000175:diagnosis*
D000998:Antiviral Agents; D000212:Acyclovir
Delir während der oralen Therapie eines Herpes zoster mit Aciclovir. Kasuistik und Kurzübersicht über zentralnervöse Nebenwirkungen von Aciclovir.