title: Poly (ADP-ribose) polymerase, a potential target for drugs: Part II. Regulation of differentiation by the poly ADP-ribose system.
abstract: It is shown that eukaryotic differentiation is specifically sensitive to pADPRT regulation in Trypanosomna, Leishmania and Mytilus models. There is powerful inhibition of early differentiation without cell toxicity by pADPRT ligands.
authors.affiliation: Octamer, Inc, CA 94710, USA.
authors.forename: E
authors.initials: E
authors.lastname: Kun
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D006801:Humans; D007891:Leishmania / Q000201:enzymology; D008024:Ligands; D049880:Mytilus edulis / Q000201:enzymology; D011065:Poly(ADP-ribose) Polymerases / Q000235:genetics / Q000378:metabolism*; D015800:Protozoan Proteins / Q000235:genetics / Q000378:metabolism; D014349:Trypanosoma cruzi / Q000201:enzymology
chemical_list: D008024:Ligands; D015800:Protozoan Proteins; D011065:Poly(ADP-ribose) Polymerases