title: Time-dependent reversal of dentate LTP by 5 Hz stimulation.
abstract: Field potential recordings were made from the dentate gyrus of urethane-anaesthetized rats in order to investigate the ability of 5 Hz stimulation to reverse long-term potentiation (LTP) induced by a high frequency tetanus. A 10 min train of 5 Hz was found to reverse LTP in a time-dependent fashion: as the interval between tetanus and 5 Hz was increased, LTP became progressively less susceptible to reversal. If 10 min or 30 min intervened between tetanization and 5 Hz stimulation, LTP was unaffected. These results indicate that dentate LTP in vivo exhibits a similar limited time window of vulnerability to reversal by low frequency stimulation to that previously reported in area CA1 in vitro.
authors.affiliation: Department of Neuroscience, University of Edinburgh, UK.
authors.forename: S J
authors.initials: SJ
authors.lastname: Martin
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D018891:Dentate Gyrus / Q000502:physiology*; D004558:Electric Stimulation; D019706:Excitatory Postsynaptic Potentials; D016014:Linear Models; D017774:Long-Term Potentiation; D008297:Male; D051381:Rats; D013746:Tetany; D013997:Time Factors