Practical synthesis of Taxol side chain.
Practical large scale synthesis of N-benzoyl-(2R,3S)-phenylisoserine methyl ester of the Taxol side chain has been attained from the coupling of chiral imine of N-[(S)-methylbenzyl]benzaldimine with (Z)-alpha-methoxy trimethylsilyl ketene acetal followed by the sequential reactions of lactamization, demethylation, methanolysis and N-benzoylation.
Ha
H J
HJ
Department of Chemistry, Hankuk University of Foreign Studies, Yongin, Kyunggi-Do, Korea. hjha@maincc.hufs.ac.kr
Park
G S
GS
Ahn
Y G
YG
Lee
G S
GS
D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000737:chemistry*; D017239:Paclitaxel / Q000138:chemical synthesis / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel