[Study and treatment of heart failure require new approaches. Natriuretic peptides can be safe and simple diagnostic and outcome measures].
Analysis of plasma natriuretic peptides and related propeptide fragments may be a cost-effective aid to diagnostic evaluation and treatment follow-up in cases of heart failure. In diagnostic potential such variables may constitute first-line measures of high negative predictive value, allowing further examination, e.g. by echocardiography, in cases where values are above the respective cut-off levels. However, in many cases evaluation of published reports is rendered difficult by their omission of information on such pre-analytical variables as blood sampling and storage, and drug therapy. Moreover, different analytical methods may yield widely divergent results. Thus, before such assays are introduced in general use, their long-term validity needs to be ensured, for instance by consistency in calibration, and measurements need to be made in representative series of unselected patients for the determination of appropriate cut-off levels.
Lindstedt
G
G
Avdelningen för klinisk kemi och transfusionsmedicin, Sahlgrenska Universitetssjukhuset/Sahlgrenska.
Bergh
C H
CH
Caidahl
K
K
Ekman
R
R
Fagerberg
B
B
Isgaard
J
J
Lundberg
P A
PA
Swedberg
K
K
Wallén
T
T
D000595:Amino Acid Sequence; D009320:Atrial Natriuretic Factor / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D015415:Biomarkers / Q000032:analysis*; D001921:Brain / Q000378:metabolism; D003937:Diagnosis, Differential; D004730:Endothelium, Vascular; D005500:Follow-Up Studies; D006333:Heart Failure / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D008969:Molecular Sequence Data; D045283:Natriuretic Agents / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D011379:Prognosis; D016896:Treatment Outcome
D015415:Biomarkers; D045283:Natriuretic Agents; D009320:Atrial Natriuretic Factor
Utredning och behandling av hjärtsvikt söker nya vägar. Natriuretiska peptider kan bli säkert och enkelt mått i diagnostik och behandling.