title: Cerebrospinal fluid ferritin in glioblastoma: evidence for tumor synthesis.
abstract: Ferritin concentrations in cerebrospinal fluid (CSF) of 16 patients with glioblastoma were found to be very high (mean, 103.0 ng/mL) relative to 29 patients with viral meningitis and 20 patients with headache (mean concentrations, 5.4 and 4.3 ng/mL respectively). Simultaneous measurement of ferritin in CSF and serum revealed CSF concentrations exceeding those in serum in 11 of 16 patients with glioblastoma (CSF vs. serum ratio, 132.6%), contrasting with very low ratios in patients with meningitis (7.9%) or headache (4.9%). Ferritin was detected immunocytochemically in tumor cell cytoplasm in a resected glioblastoma. Thus, ferritin in CSF appears to be produced by glioblastoma cells, with a biologic significance requiring further investigation.
authors.affiliation: Department of Neurology, Futase Social Insurance Hospital, Iizuka, Japan. y-sato@ktarn.or.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Sato
authors.forename: Y
authors.initials: Y
authors.lastname: Honda
authors.forename: T
authors.initials: T
authors.lastname: Asoh
authors.forename: K
authors.initials: K
authors.lastname: Oizumi
authors.forename: Y
authors.initials: Y
authors.lastname: Ohshima
authors.forename: E
authors.initials: E
authors.lastname: Honda
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001932:Brain Neoplasms / Q000134:cerebrospinal fluid*; D005260:Female; D005293:Ferritins / Q000096:biosynthesis / Q000134:cerebrospinal fluid*; D005909:Glioblastoma / Q000134:cerebrospinal fluid*; D006261:Headache / Q000134:cerebrospinal fluid; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008587:Meningitis, Viral / Q000134:cerebrospinal fluid
chemical_list: D005293:Ferritins