Immunosuppressant activity in human beta-casein fragment analogs.
Human beta-casein fragment (54-59) having the amino acid sequence Val-Glu-Pro-Ile-Pro-Tyr, has been shown potent immunostimulant activity. Several analogs of this hexapeptide have been synthesized with modification in the N-terminal region and tested for their immunomodulatory activity. Interestingly, two hexapeptides have shown significant immunosuppressant activity.
Bhattacharya
M
M
Division of Biopolymers, Central Drug Research Institute, Lucknow, India.
Puri
A
A
Sahai
R
R
Haq
W
W
Tripathi
L M
LM
Srivastava
V M
VM
D000595:Amino Acid Sequence; D000818:Animals; D002364:Caseins / Q000737:chemistry*; D002478:Cells, Cultured; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D010446:Peptide Fragments / Q000737:chemistry / Q000494:pharmacology*
D002364:Caseins; D007166:Immunosuppressive Agents; D010446:Peptide Fragments