[The biological activity of a lipopolysaccharide from Ralstonia solanacearum ICMP 7859 and of its modified derivative].
Coordinational compound of the Ralstonia solanacearum ICMP 7859 lipopolysaccharide (LPS) with germanium was obtained. The derivative has lost to considerable extent its toxicity (as compared to the initial substance) but preserves immunomodulating activity, interferon-inducing one in particular. Lipid A modification has led to complete loss of interferon-inducing activity. Apparently, phosphate at C4' GlcN II can be responsible for interferon-inducing activity of lipid A, while carboxylic groups of core oligosaccharide or 0-specific polysaccharide, are responsible for that in native molecule of LPS.
Varbanets
L D
LD
Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kyiv.
Seĭfullina
I I
II
Rybalko
S L
SL
Diadiun
S T
ST
Brovarskaia
O S
OS
D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D016946:Gram-Negative Aerobic Rods and Cocci; D006801:Humans; D007369:Interferon Inducers / Q000494:pharmacology / Q000633:toxicity; D007962:Leukocytes / Q000187:drug effects; D008050:Lipid A / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000633:toxicity; D008070:Lipopolysaccharides / Q000494:pharmacology* / Q000633:toxicity; D013329:Structure-Activity Relationship; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects
D007369:Interferon Inducers; D008050:Lipid A; D008070:Lipopolysaccharides
Biologicheskaia aktivnost' lipopolisakharida Ralstonia solanacearum ICMP 7859 i ego modifitsirovannogo proizvodnogo.