title: Prodrug esters of the indolocarbazole CEP-751 (KT-6587).
abstract: Prodrug esters of the indolocarbazole CEP-751 (KT-6587) were prepared with the goal of identifying water soluble, stable but cleavable forms for intravenous dosing. A dipeptide proform Lys-beta-Ala (16, CEP-2563/KT-8391) was identified for advancement to clinical trials.
authors.affiliation: Department of Chemistry, Cephalon, Inc., West Chester, PA 19380, USA.
authors.forename: R L
authors.initials: RL
authors.lastname: Hudkins
authors.forename: M
authors.initials: M
authors.lastname: Iqbal
authors.forename: C H
authors.initials: CH
authors.lastname: Park
authors.forename: J
authors.initials: J
authors.lastname: Goldstein
authors.forename: J L
authors.initials: JL
authors.lastname: Herman
authors.forename: E
authors.initials: E
authors.lastname: Shek
authors.forename: C
authors.initials: C
authors.lastname: Murakata
authors.forename: J P
authors.initials: JP
authors.lastname: Mallamo
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D002227:Carbazoles / Q000493:pharmacokinetics / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004952:Esters; D006801:Humans; D011355:Prodrugs / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; C107558:CEP 751; D002227:Carbazoles; D004952:Esters; D011355:Prodrugs