Gallstones and isoflurane hepatitis.
This report is of a case of a previously fit 65-year-old woman who developed postoperative liver dysfunction following an anaesthetic involving isoflurane. Biliary ultrasound demonstrated gallstones. However, serum antibodies to trifluoroacetylated proteins were detected, suggesting that immune sensitisation to the anaesthetic could have contributed to the impaired liver function.
Meldrum
D J
DJ
Department of Anaesthesia, Hinchingbrooke Hospital, Huntingdon, UK.
Griffiths
R
R
Kenna
J G
JG
D000368:Aged; D018685:Anesthetics, Inhalation / Q000009:adverse effects* / Q000276:immunology; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D002769:Cholelithiasis / Q000150:complications*; D004342:Drug Hypersensitivity / Q000209:etiology; D005260:Female; D006505:Hepatitis / Q000209:etiology*; D006801:Humans; D007530:Isoflurane / Q000009:adverse effects* / Q000276:immunology; D011183:Postoperative Complications
D018685:Anesthetics, Inhalation; D007530:Isoflurane