[Experimental study on effect of bushen shengjing decoction on kidney yang and testicular dysfunction in rats].
OBJECTIVE
To explore the therapeutical mechanism of Bushen Shengjing Decoction (BSSJD) in treating infertility.


METHODS
Fed Wistar male rats with adenine 30 mg/100 g.d continuously for 30 days. The rats manifested the symptom which was similar to the human Kidney Yang Deficiency, the genitality dropped, the function of sperm-producing in the testis was disturbed, the contents of luteinizing hormone (LH), testosterone (T) and compound F (F) in blood were all lower than rats of normal group, P < 0.01. The model rats took the BSSJD 3 ml/100 g.d (each ml contains crude drugs 2 g) continuously for 10 days, interval for three days, then medicated again and total medication of BSSJD was 30 days.


RESULTS
The symptom of Kidney Yang Deficiency in rats was improved obviously, the genitality, sperm quality and function of sperm producing in testis were all enhanced obviously, so did the hormone level of LH, T, F in blood. Comparing to untreated control group, the difference was significant (P < 0.05).


CONCLUSIONS
BSSJD has the function of reinforcing Yang and replenishing essence and regulate the endocrinological function.
Yue
G P
GP
Institute of Acupuncture and Meridians, Anhui College of TCM, Hefei.
Chen
Q
Q
Dai
N
N
D000225:Adenine; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005303:Fertility Agents, Male / Q000627:therapeutic use; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013081:Sperm Motility / Q000187:drug effects; D013733:Testicular Diseases / Q000188:drug therapy*; D016711:Yang Deficiency / Q000139:chemically induced / Q000188:drug therapy*
D004365:Drugs, Chinese Herbal; D005303:Fertility Agents, Male; D000225:Adenine