Solid-phase synthesis of peptidomimetic oligomers with a phosphodiester backbone.
An unnatural biopolymer is described in which amino acid side-chains are presented along a negatively charged phosphodiester backbone. For this purpose, a series of phosphoramidite monomers was prepared from chiral 1,2-diols. These were efficiently converted into oligomers using standard coupling conditions on an automated DNA synthesizer.
Lin
P
P
Institute of Molecular and Cell Biology, National University of Singapore, Singapore.
Ganesan
A
A
D001704:Biopolymers; D004952:Esters; D018716:Molecular Mimicry; D009943:Organophosphorus Compounds / Q000737:chemistry; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D010727:Phosphoric Diester Hydrolases / Q000138:chemical synthesis*
D001704:Biopolymers; D004952:Esters; D009943:Organophosphorus Compounds; D010455:Peptides; D010727:Phosphoric Diester Hydrolases