[The evaluation of the action of microbial enzyme preparations on the motility of the rat and canine small intestine].
The effect of combined microbial enzyme agents trizyme and triaze containing alkaline and neutral proteases, lipase, and amilase on the evacuation capacity of the small intestine of conscious rats and of the dog small intestine operated on by the Thiry-Vella method. Therapeutic doses of the enzymatic agents had no noticeable effect on the evacuation function of the intestine. The contraction of bands of the rat intestine induced by electrical stimulation depended on the concentration of the perfusate of the solution of the enzymatic agents. Low concentration of the agents caused no effect or weakly activated the contractions of the smooth intestinal muscles. Doses of the agents higher than the mean therapeutic doses caused decrease of the contraction amplitude of the intestinal bands by 30-40%.
Beliaev
O A
OA
Department of Normal Physiology, St. Petersburg Pediatric Medical Academy, Russia.
Fedin
A N
AN
D000818:Animals; D001412:Bacillus subtilis / Q000201:enzymology*; D004285:Dogs; D004798:Enzymes / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D066298:In Vitro Techniques; D007421:Intestine, Small / Q000187:drug effects* / Q000502:physiology; D010407:Penicillium / Q000201:enzymology*; D051381:Rats; D013607:Tablets
D004798:Enzymes; D013607:Tablets
Otsenka deĭstviia preparatov mikrobnykh fermentov na motoriku tonkoĭ kishki krys i sobak.