[Protective role of the glutathione system in rat organs after administration of embiquine].
Dynamics of changes of the reduced glutathione contents, activity of glutathione transferase, glutathione reductase and gamma-glutamyl transpeptidase in rat organs at a single injection of embiquine in a dose of 1/2 LD50 has been studied. It was shown that injection of the alkylating antitumor preparation lead to the decrease of the reduced glutathione contents in the early period of intoxication together with compensatory increase of tripeptide concentrations 3 hours later in the liver tissue and 24 hours later in the kidney tissue. Embiquine caused the steady increase of the glutathione transferase activity in all the organs studied. Significant increase of liver, kidney and spleen gamma-glutamyl transpeptidase by the end of the investigation period was noted at the injection of the alkylating agent.
Boĭtsova
L V
LV
Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine, Kyiv.
D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000633:toxicity*; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D005978:Glutathione / Q000378:metabolism*; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008466:Mechlorethamine / Q000633:toxicity*; D010084:Oxidation-Reduction; D051381:Rats; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D018906:Antineoplastic Agents, Alkylating; D008466:Mechlorethamine; D005980:Glutathione Reductase; D005723:gamma-Glutamyltransferase; D005982:Glutathione Transferase; D005978:Glutathione
Zashchitnaia rol' glutationovoĭ sistemy v organakh krys pri vvedenii émbikhina.