title: Heteroatom- and carbon-linked biphenyl analogs of Brequinar as immunosuppressive agents.
abstract: Structure-activity relationships were explored for some analogs of Brequinar having a linking atom between the 2-biphenyl substituent and the quinoline ring. Activities as inhibitors of dihydroorotate dehydrogenase and the mixed lymphocyte reaction were related to the overall shape and lipophilicity of the 2-substituent.
authors.affiliation: DuPont Merck Pharmaceutical Company, Wilmington, Delaware 19880-0500, USA.
authors.forename: D G
authors.initials: DG
authors.lastname: Batt
authors.forename: J J
authors.initials: JJ
authors.lastname: Petraitis
authors.forename: S R
authors.initials: SR
authors.lastname: Sherk
authors.forename: R A
authors.initials: RA
authors.lastname: Copeland
authors.forename: R L
authors.initials: RL
authors.lastname: Dowling
authors.forename: T L
authors.initials: TL
authors.lastname: Taylor
authors.forename: E A
authors.initials: EA
authors.lastname: Jones
authors.forename: R L
authors.initials: RL
authors.lastname: Magolda
authors.forename: B D
authors.initials: BD
authors.lastname: Jaffee
mesh_terms: D001713:Biphenyl Compounds / Q000737:chemistry; D002244:Carbon / Q000737:chemistry; D007166:Immunosuppressive Agents / Q000737:chemistry* / Q000494:pharmacology*; D007959:Lymphocyte Culture Test, Mixed; D013329:Structure-Activity Relationship
chemical_list: D001713:Biphenyl Compounds; D007166:Immunosuppressive Agents; D002244:Carbon