title: Design, synthesis and biological activity of a pyrrolo [2,1-c][1,4]benzodiazepine (PBD)-distamycin hybrid.
abstract: We report the synthesis of a new hybrid 13 which is a combination of the naturally occurring antitumor agent distamycin A 1 and the pyrrolo[2,1-c][1,4]benzodiazepine 11, related to the naturally occurring anthramycin 2. The antitumor activity of the hybrid 13 was tested in vitro and compared to the natural product distamycin 1 and the PBD 11.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Italy. pgb@dns.unife.it
authors.forename: P G
authors.initials: PG
authors.lastname: Baraldi
authors.forename: B
authors.initials: B
authors.lastname: Cacciari
authors.forename: A
authors.initials: A
authors.lastname: Guiotto
authors.forename: A
authors.initials: A
authors.lastname: Leoni
authors.forename: R
authors.initials: R
authors.lastname: Romagnoli
authors.forename: G
authors.initials: G
authors.lastname: Spalluto
authors.forename: N
authors.initials: N
authors.lastname: Mongelli
authors.forename: P W
authors.initials: PW
authors.lastname: Howard
authors.forename: D E
authors.initials: DE
authors.lastname: Thurston
authors.forename: N
authors.initials: N
authors.lastname: Bianchi
authors.forename: R
authors.initials: R
authors.lastname: Gambari
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D004247:DNA / Q000378:metabolism; D004214:Distamycins / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D015195:Drug Design; D006801:Humans; D020014:K562 Cells; D016133:Polymerase Chain Reaction
chemical_list: D000970:Antineoplastic Agents; D004214:Distamycins; D001569:Benzodiazepines; C030000:stallimycin; D004247:DNA