title: Development of primary leiomyosarcoma of the sternum postirradiation: report of a case.
abstract: We report herein the case of a 30-year-old man who developed a primary leiomyosarcoma (LMS) 11 years after undergoing a median sternotomy for mediastinal seminoma followed by 50 Gy radiotherapy. He was given two courses of chemotherapy, resulting in 90% tumor regression, after which resection of the tumor with adjacent chest wall structures was carried out. Reconstruction was performed using a methylmethacrylate prosthesis prepared preoperatively. Postoperatively, he received two additional courses of chemotherapy and has had no sign of recurrence for 45 months.
authors.affiliation: Department of Surgery, Saiseikai Kanagawaken Hospital, Yokohama, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Aoki
authors.forename: Y
authors.initials: Y
authors.lastname: Ozeki
authors.forename: M
authors.initials: M
authors.lastname: Watanabe
authors.forename: S
authors.initials: S
authors.lastname: Tanaka
authors.forename: H
authors.initials: H
authors.lastname: Isaki
authors.forename: S
authors.initials: S
authors.lastname: Terahata
mesh_terms: D000328:Adult; D000792:Angiography; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D001859:Bone Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007890:Leiomyosarcoma / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D008297:Male; D008768:Methylmethacrylates; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D019736:Prostheses and Implants; D013249:Sternum; D014057:Tomography, X-Ray Computed
chemical_list: D008768:Methylmethacrylates