title: Immunoexpression of mutant p53 and human papillomavirus related E6 oncoprotein in anal malignancies.
abstract: Immunohistochemical expression of mutant p53 protein and human papillomavirus (HPV) 16 and 18 related E6 oncoprotein was studied in 36 biopsy proved anal cancers. Mutant p53 was detected in 61.1% cases. HPV 16 and 18 E6 protein was expressed in 22.2% cases, all of which were squamous cell carcinomas. Coexpression of both mutant p53 and E6 protein was found in only 5 cases (13.8%). In HPV 16/18 positive anal tumors, the degradation of p53 is accelerated by viral E6 oncoprotein. In HPV negative tumors, however, other mutagenic factors probably play a role in carcinogenesis.
authors.affiliation: Division of Cytopathology, Institute of Cytology and Preventive Oncology (ICMR), New Delhi, India.
authors.forename: S
authors.initials: S
authors.lastname: Gupta
authors.forename: B K
authors.initials: BK
authors.lastname: Sharma
mesh_terms: D000328:Adult; D000368:Aged; D001005:Anus Neoplasms / Q000209:etiology / Q000235:genetics* / Q000821:virology*; D004268:DNA-Binding Proteins; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009856:Oncogene Proteins, Viral / Q000378:metabolism*; D027383:Papillomaviridae / Q000378:metabolism / Q000472:pathogenicity; D012097:Repressor Proteins; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; C068651:E6 protein, Human papillomavirus type 16; C052603:E6 protein, Human papillomavirus type 18; D009856:Oncogene Proteins, Viral; D012097:Repressor Proteins; D016159:Tumor Suppressor Protein p53