[Antigenic activity of delta-antigen peptides corresponding to three genotypes of the delta hepatitis virus].
Six synthetic peptides from immunodominant region 65-80 aa derived from the sequences of delta-antigen corresponding to 3 HDV genotypes were obtained. Their antigenic activities were assessed by indirect enzyme immunoassay with sera of patients with hepatitis D and of asymptomatic carriers of anti-delta antibodies. Differences in antigenic characteristics of full-size 65-80 and truncated 71-80 aa peptides corresponding to three HDV genotypes were revealed. The diagnostic significance of synthetic 65-80 aa fragments is shown.
Dement'eva
E V
EV
Kruglov
I V
IV
Pimenov
V K
VK
Semiletov
Iu A
IuA
D000595:Amino Acid Sequence; D000914:Antibodies, Viral / Q000097:blood; D002353:Carrier State; D005838:Genotype; D018963:Hepatitis Antigens / Q000737:chemistry / Q000276:immunology*; D003699:Hepatitis D / Q000276:immunology; D003698:Hepatitis Delta Virus / Q000235:genetics / Q000276:immunology*; D035923:Hepatitis delta Antigens; D006801:Humans; D007124:Immunoenzyme Techniques; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000737:chemistry / Q000276:immunology*
D000914:Antibodies, Viral; D018963:Hepatitis Antigens; D035923:Hepatitis delta Antigens; D010446:Peptide Fragments; C442244:hepatitis delta virus large antigen
Antigennaia aktivnost' peptidov del'ta-antigena, sootvetstvuiushchikh trem genotipam virusa gepatita del'ta.