Complexation of okadaic acid: a preliminary study.
A complexation study was carried out with okadaic acid (OA) and the univalent metal ions Li+, Na+ and K+, and the divalent metal ions Ca2+ and Mg2+. K+ binding was observed identical with a complex obtained from the natural source (OAC). The pharmacological trials demonstrated that this cation has a very important influence on the pharmacological activity of okadaic acid.
Norte
M
M
Instituto Universitario de Bioorgánica Antonio González, Universidad de La Laguna, Tenerife, Spain. mnorte@ull.es
Fernández
J J
JJ
Souto
M L
ML
Gavín
J A
JA
Candenas
M L
ML
Ausina
P
P
D002118:Calcium / Q000737:chemistry; D002413:Cations, Divalent / Q000737:chemistry*; D002414:Cations, Monovalent / Q000737:chemistry*; D007700:Kinetics; D008094:Lithium / Q000737:chemistry; D008274:Magnesium / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D019319:Okadaic Acid / Q000737:chemistry* / Q000494:pharmacology; D011188:Potassium / Q000737:chemistry; D012964:Sodium / Q000737:chemistry
D002413:Cations, Divalent; D002414:Cations, Monovalent; D019319:Okadaic Acid; D008094:Lithium; D012964:Sodium; D008274:Magnesium; D011188:Potassium; D002118:Calcium