[Immunological aspects of a child with idiopathic pulmonary hemosiderosis and celiac disease].
A case report of a girl aged 3.5 years affected by the extremely rare combination of idiopathic pulmonary haemosiderosis (IPH) and coeliac disease (CD) is presented. It is the 13th such case that has been published over the last 25 years and only the 7th to be reported in a child. We believe that the concurrence of these two diseases is not coincidental, because a gluten-free diet had beneficial effects on the pulmonary symptoms not only in our case but also in other such patients. However, the pathogenetic relation between IPH and CD remains unclear. Although circulating immune complexes were detected in our patient's serum, there was no evidence of their putative damaging effect on the basement membrane of the alveolar capillaries. Furthermore, no IgA deposits could be demonstrated in alveolar basement membranes. Therefore the hypothesis that there is a reaction between IgA reticulin or endomysial antibodies and an alveolar basement membrane antigen with consecutive structural damage is unlikely.
Ploier
R
R
Kinderabteilung, Landeskrankenhaus Steyr.
Emhofer
J
J
Dorninger
L
L
Kranzl
G
G
Feichtinger
J
J
Müller
K M
KM
Brandtzaeg
P
P
D000936:Antigen-Antibody Complex / Q000097:blood; D002447:Celiac Plexus / Q000276:immunology* / Q000473:pathology; D002675:Child, Preschool; D005260:Female; D006486:Hemosiderosis / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D008171:Lung Diseases / Q000276:immunology* / Q000473:pathology
D000936:Antigen-Antibody Complex; D007070:Immunoglobulin A
Immunologische Aspekte bei idiopathischer Lungenhämosiderose und Zöliakie.