Synthesis and comparative evaluation of two antiviral agents: beta-L-Fd4C and beta-D-Fd4C.
The synthesis of beta-D-Fd4C was achieved in a stereoselective fashion from D-xylose. The antiviral activity and cytotoxicity of beta-D-Fd4C was compared with that of beta-L-Fd4C and 3TC (Lamivudine). Of the three agents compared, beta-L-Fd4C was found to be the most potent antiviral agent.
Chen
S H
SH
Vion Pharmaceuticals, Inc., Four Science Park, New Haven, CT 06511, USA.
Lin
S
S
King
I
I
Spinka
T
T
Dutschman
G E
GE
Gullen
E A
EA
Cheng
Y C
YC
Doyle
T W
TW
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006678:HIV / Q000187:drug effects; D006515:Hepatitis B virus / Q000187:drug effects; D051379:Mice; D051381:Rats; D013237:Stereoisomerism; D016047:Zalcitabine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
D000998:Antiviral Agents; D016047:Zalcitabine; C099405:dexelvucitabine