Effect of oral administration of Pinellia ternata, Zingiberis rhizoma and their mixture on the efferent activity of the gastric branch of the vagus nerve in the rat.
The effect of taste stimulation of Pinellia temata, Zingiberis rhizoma and their mixture on the efferent activity of the gastric branch of the vagus nerve was observed in the anesthetized rat. Taste stimulation by Pinellia ternata (50 mg/ml, 10 min) resulted in a suppression in vagal gastric nerve activity. On the contrary, stimulation by Zingiberis rhizoma (50 mg/ml, 10 min) caused a facilitation in efferent activity. The mixture of Pinellia ternata and Zingiberis rhizoma (5:1, 50 mg/ml, 10 min stimulation) demonstrated no suppressive effect on gastric nerve activity. These observations indicate that it is reasonable to prescribe Pinellia ternata with Zingiberis rhizoma in traditional Japanese medicine to prevent suppressive effect of the taste of Pinellia ternata on gastric function.
Niijima
A
A
Niigata University School of Medicine, Department of Physiology, Japan.
Kubo
M
M
Hashimoto
K
K
Komatsu
Y
Y
Maruno
M
M
Okada
M
M
D000284:Administration, Oral; D000818:Animals; D019771:Axotomy; D004525:Efferent Pathways / Q000187:drug effects* / Q000502:physiology*; D005071:Evoked Potentials / Q000187:drug effects; D005930:Glossopharyngeal Nerve / Q000502:physiology; D008036:Lingual Nerve / Q000502:physiology; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013270:Stomach / Q000294:innervation*; D013649:Taste / Q000502:physiology; D014630:Vagus Nerve / Q000187:drug effects* / Q000502:physiology*
D010936:Plant Extracts