[Increase of circulating CD3+CD4-CD8-CD19+ cells in the latent phase of HIV-1 infection].
Having reported that HIV-1-infected T cell lines are rescued as CD4- from cytolysis by human complement factor B, we now show the presence of an in vivo counterpart of such CD4- T cells by demonstrating the circulating CD3+ CD4- CD8- CD29+ cells in the blood of seropositive subjects (n = 91, classified by the immunologic scale scores 0, 1, 2 and 3). The cell population was found to be significantly increased in the early phase of infection in score 0: 195/mm3 (p < 0.005) and in score 1:376/mm3 (p = 0.001). With the infection progressing to score 2, the cells decreased to 220/mm3 (p < 0.001) and finally to the same range: 101/mm3, as that of uninfected subjects. Further elucidation of the mechanism of the appearance and disappearance of that population in vivo could help to elucidate protective immunologic processes.
Nozaki-Renard
J
J
Department of Microbiology, Tokyo Medical College.
O'Leary
J
J
Zolla-Pazner
S
S
Tada
T
T
D015703:Antigens, CD / Q000097:blood*; D017252:CD3 Complex / Q000097:blood; D015704:CD4 Antigens / Q000097:blood; D016827:CD8 Antigens / Q000097:blood; D002460:Cell Line; D005434:Flow Cytometry / Q000379:methods; D015658:HIV Infections / Q000097:blood / Q000276:immunology*; D006679:HIV Seropositivity / Q000097:blood / Q000276:immunology*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D016130:Immunophenotyping; D019012:Integrin beta1 / Q000097:blood; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D017735:Virus Latency
D015703:Antigens, CD; D017252:CD3 Complex; D015704:CD4 Antigens; D016827:CD8 Antigens; D019012:Integrin beta1
Accroissement des cellules circulantes CD3+CD4-CD8-CD29+ pendant la phase latente de l'infection par le VIH-1.