title: Malignant schwannoma in a red deer (Cervus elaphus).
abstract: A five-year-old female red deer (Cervus elaphus) was in poor condition and severely lame on the left hindleg owing to a 19.4 cm x 15.9 cm mass involving and destroying the distal end (head) of metatarsal bones III and IV, the proximal sesamoid bones and the first phalanges (III and IV). The histopathological analysis revealed a spindle cell tumour with frequent palisade arrangement (Antoni type A pattern), and with highly anaplastic tumour cells in some areas. Structures resembling peripheral nerves were identified within the tumour. The neoplastic cells reacted with vimentin in a cytoplasmic pattern, and almost all of them reacted with S-100 protein in a nuclear and cytoplasmic pattern and did not express neurofilament, glial fibrillary acidic protein or keratins. This immunophenotype and the histopathological features were consistent with a diagnostic of malignant schwannoma. It was atypical because of the species affected, the location and the local malignancy.
authors.affiliation: Departamento de Anatomía y Anatomía Patalógica Comparadas, Facultad de Veterinaria, Córdoba, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Pérez
authors.forename: J
authors.initials: J
authors.lastname: Martín de las Mulas
authors.forename: A
authors.initials: A
authors.lastname: Arenas
authors.forename: I
authors.initials: I
authors.lastname: Luque
authors.forename: L
authors.initials: L
authors.lastname: Carrasco
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D003670:Deer; D005260:Female; D006614:Hindlimb / Q000473:pathology; D016130:Immunophenotyping; D007794:Lameness, Animal / Q000209:etiology; D009442:Neurilemmoma / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*