title: Evaluation of phosphorus-containing inhibitors of gamma-glutamyl hydrolase.
abstract: Several putative, phosphorus-containing inhibitors of gamma-glutamyl hydrolase were synthesized and evaluated for inhibitory activity. The phosphonamidoic acids were shown to be weak competitive inhibitors while both a phosphoramidate diester and a phosphonamidate ester were shown to be potent time-dependent inactivators, presumably through irreversible phosphorylation of an active site nucleophile.
authors.affiliation: Department of Chemistry & Biochemistry, San Francisco State University, CA 94132, USA.
authors.forename: C E
authors.initials: CE
authors.lastname: Rodriguez
authors.forename: H M
authors.initials: HM
authors.lastname: Holmes
authors.forename: K L
authors.initials: KL
authors.lastname: Mlodnosky
authors.forename: V Q
authors.initials: VQ
authors.lastname: Lam
authors.forename: C E
authors.initials: CE
authors.lastname: Berkman
mesh_terms: D004341:Drug Evaluation; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D007700:Kinetics; D010758:Phosphorus / Q000032:analysis*; D010766:Phosphorylation; D011623:gamma-Glutamyl Hydrolase / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D010758:Phosphorus; D011623:gamma-Glutamyl Hydrolase