title: N-(2-(4-hydroxyphenyl)ethyl)-4-chlorocinnamide: a novel antagonist at the 1A/2B NMDA receptor subtype.
abstract: A series of N-(2-phenethyl)cinnamides was synthesized and assayed for antagonism at three N-methyl-D-asparate (NMDA) receptor subtypes (NR1A/2A-C). N-(2-(4-hydroxyphenyl)ethyl)-4-chlorocinnamide (6) was identified as a highly potent and selective antagonist of the NR1A/2B subtype.
authors.affiliation: Department of Chemistry, University of Oregon, Eugene 97403, USA.
authors.forename: A P
authors.initials: AP
authors.lastname: Tamiz
authors.forename: E R
authors.initials: ER
authors.lastname: Whittemore
authors.forename: R M
authors.initials: RM
authors.lastname: Schelkun
authors.forename: P W
authors.initials: PW
authors.lastname: Yuen
authors.forename: R M
authors.initials: RM
authors.lastname: Woodward
authors.forename: S X
authors.initials: SX
authors.lastname: Cai
authors.forename: E
authors.initials: E
authors.lastname: Weber
authors.forename: J F
authors.initials: JF
authors.lastname: Keana
mesh_terms: D002934:Cinnamates / Q000737:chemistry / Q000494:pharmacology*; D018691:Excitatory Amino Acid Antagonists / Q000737:chemistry / Q000494:pharmacology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
chemical_list: D002934:Cinnamates; D018691:Excitatory Amino Acid Antagonists; C116443:N-(2-(hydroxyphenyl)ethyl)-4-chlorocinnamide; D016194:Receptors, N-Methyl-D-Aspartate