title: Ketosis resistance in the male offspring of protein-malnourished rat dams.
abstract: Plasma beta-hydroxybutyrate concentrations were measured in the offspring of rats that were fed either a control (20% protein) diet or low-protein (8% protein) diet during pregnancy and lactation. Low-protein offspring had significantly lower plasma beta-hydroxybutyrate compared with controls in the fed state (P < .04) and after fasting for 24 hours (P < .001) and 48 hours (P < .04). There were no differences in blood glucose, acetoacetate, plasma glucagon, cholesterol, or glycerol between control and low-protein offspring. However, plasma nonesterified fatty acids (NEFAs) were significantly higher in low-protein offspring in the fed state (P < .05). In contrast, plasma triglycerides and insulin were significantly lower in low-protein offspring compared with controls when fed (P < .001) and after a 24-hour fast (P < .001). These results suggest that poor maternal and early postnatal nutrition can have long-term effects on ketone body metabolism in the offspring during adulthood. This apparent ketosis resistance is similar to that observed in some forms of human diabetes.
authors.affiliation: Department of Clinical Biochemistry, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: S E
authors.initials: SE
authors.lastname: Ozanne
authors.forename: C L
authors.initials: CL
authors.lastname: Wang
authors.forename: C J
authors.initials: CJ
authors.lastname: Petry
authors.forename: J M
authors.initials: JM
authors.lastname: Smith
authors.forename: C N
authors.initials: CN
authors.lastname: Hales
mesh_terms: D020155:3-Hydroxybutyric Acid / Q000097:blood; D000090:Acetoacetates / Q000097:blood; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D018753:Diet, Protein-Restricted; D005215:Fasting; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005934:Glucagon / Q000097:blood; D005990:Glycerol / Q000097:blood; D007328:Insulin / Q000097:blood; D007662:Ketosis / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
chemical_list: D000090:Acetoacetates; D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D014280:Triglycerides; C016635:acetoacetic acid; D005934:Glucagon; D002784:Cholesterol; D005990:Glycerol; D020155:3-Hydroxybutyric Acid