title: Candida fungemia in neonates treated with fluconazole: report of forty cases, including eight with meningitis.
abstract: OBJECTIVE
  To assess efficacy and safety of fluconazole in neonates with Candida fungemia.
  
  
  METHODS
  Multicenter prospective protocol of all fungemias appearing between January 1, 1993, and December 31, 1997, in four major university hospitals.
  
  
  RESULTS
  Forty neonates, 28 of them with very low birth weight (<1500 g; 30.5 median gestation week), with documented Candida albicans fungemia were treated with intravenous fluconazole in a daily dosage of 6 mg/kg once daily for 6 to 48 days. Thirty-four received fluconazole as monotherapy and 6 received it in combination with amphotericin B. Thirty-two (80%) were cured; 4 of them relapsed despite at least 14 days of therapy, but they were ultimately cured without sequelae. Eight other neonates died, 4 because of fungal infection and 4 because of prematurity or hemorrhage or lung failure, with fungemia (20% overall and 10% attributable mortality). Two neonates had elevated liver enzymes during fluconazole therapy and 2 others had elevated serum creatinine during fluconazole monotherapy. In none of them did these abnormalities necessitate discontinuation of antifungal therapy. In 8 neonates fungal meningitis developed as a complication of fungemia. All but 3 fungemias were C. albicans; 3 were Candida parapsilosis.
  
  
  CONCLUSIONS
  Fluconazole was safe and effective antifungal therapy even in complicated or Candida fungemia in neonates and in infants with very low birth weight.
authors.affiliation: Department of Neonatology, Pediatric ICU, Postgraduate Medical School, Bratislava, Slovak Republic.
authors.forename: M
authors.initials: M
authors.lastname: Huttova
authors.forename: I
authors.initials: I
authors.lastname: Hartmanova
authors.forename: K
authors.initials: K
authors.lastname: Kralinsky
authors.forename: J
authors.initials: J
authors.lastname: Filka
authors.forename: J
authors.initials: J
authors.lastname: Uher
authors.forename: J
authors.initials: J
authors.lastname: Kurak
authors.forename: S
authors.initials: S
authors.lastname: Krizan
authors.forename: V
authors.initials: V
authors.lastname: Krcmery
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D002177:Candidiasis / Q000188:drug therapy*; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use*; D016469:Fungemia / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D016921:Meningitis, Fungal / Q000188:drug therapy*; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole