Methotrexate-induced hepatic necrosis requiring liver transplantation in a patient with rheumatoid arthritis.
MTX-induced hepatic injury and liver enzyme elevations have been demonstrated after treatment of leukemia, gestational disease and during treatment of psoriasis and rheumatoid arthritis. A 40-year-old man with a long standing history of rheumatoid arthritis was treated with MTX over a 6 month period and developed an overwhelming hepatic necrosis. He was successfully transplanted.
Hakim
N S
NS
Department of Surgery, University of Minnesota, Minneapolis, USA.
Kobienia
B
B
Benedetti
E
E
Bloomer
J
J
Payne
W D
WD
D000328:Adult; D018501:Antirheumatic Agents / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy*; D056486:Chemical and Drug Induced Liver Injury; D006801:Humans; D008107:Liver Diseases / Q000150:complications / Q000473:pathology / Q000601:surgery; D016031:Liver Transplantation; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D009336:Necrosis
D018501:Antirheumatic Agents; D008727:Methotrexate