Cholestasis secondary to Hodgkin's disease: report of 2 cases of vanishing bile duct syndrome.
Only a small percentage of patients with Hodgkin's disease become clinically Jaundiced during their disease. This Jaundice may be secondary to biliary obstruction, hemolysis, direct hepatic infiltration by the disease, drug toxicity or viral hepatitis. Vanishing bile duct syndrome secondary to Hodgkin's disease is a rare cause of cholestasis in these patients, only 13 cases having been reported so far. The authors describe 2 patients who developed severe Jaundice secondary to Hodgkin's disease due to vanishing bile duct syndrome affecting small intrahepatic bile ducts.
de Medeiros
B C
BC
Bone Marrow Transplantation Service, Hospital de Clínicas, UFPR, Curitiba, Paraná, Brazil. medeiros@avalon.sul.com.br
Lacerda
M A
MA
Telles
J E
JE
da Silva
J A
JA
de Medeiros
C R
CR
D000328:Adult; D001652:Bile Ducts / Q000473:pathology*; D001706:Biopsy; D002780:Cholestasis, Intrahepatic / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006689:Hodgkin Disease / Q000150:complications*; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000209:etiology / Q000473:pathology; D008111:Liver Function Tests; D008875:Middle Aged; D013577:Syndrome; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use
D014580:Ursodeoxycholic Acid