title: A synthetic acceptor substrate for Trypanosoma brucei UDP-Gal: GPI anchor side-chain alpha-galactosyltransferases.
abstract: A synthetic analogue of a trisaccharide fragment of the Trypanosoma brucei Variant Surface Glycoprotein (VSG) GlycosylPhosphatidyInositiol (GPI) anchor, Gal-alpha-1,3(Man-alpha-1,6)-Man-alpha-O-octyl (1), serves as a substrate for two T. brucei alpha-galactosyltransferases. The principle tetrasaccharide product derived from (1) contains a Gal-alpha-1,2-Gal linkage.
authors.affiliation: School of Chemistry, University of St Andrews, UK.
authors.forename: J R
authors.initials: JR
authors.lastname: Brown
authors.forename: T K
authors.initials: TK
authors.lastname: Smith
authors.forename: M A
authors.initials: MA
authors.lastname: Ferguson
authors.forename: R A
authors.initials: RA
authors.lastname: Field
mesh_terms: D000818:Animals; D001711:Biotransformation; D002240:Carbohydrate Sequence; D005700:Galactosyltransferases / Q000378:metabolism*; D017261:Glycosylphosphatidylinositols / Q000378:metabolism*; D008969:Molecular Sequence Data; D013379:Substrate Specificity; D014346:Trypanosoma brucei brucei / Q000201:enzymology*; D014531:Uridine Diphosphate Galactose / Q000378:metabolism*; D014643:Variant Surface Glycoproteins, Trypanosoma / Q000378:metabolism*
chemical_list: D017261:Glycosylphosphatidylinositols; D014643:Variant Surface Glycoproteins, Trypanosoma; D014531:Uridine Diphosphate Galactose; D005700:Galactosyltransferases