title: Radio-opaque markers for stereotactic imaging of uveal melanoma.
abstract: In in vitro and in vivo studies, episclerally sutured radio-opaque markers were evaluated as localizers for better determination of the clinical tumour volume prior to stereotactic radio-therapy of uveal melanoma. Four different types of markers were studied in vitro: tantalum marker, 2.5 mm in diameter; ring-shaped markers custom-designed in polymethyl methacrylate (PMMA), 2.6 mm and 3.0 mm in diameter; and barium-impregnated silicone rubber spheres, 2 mm in diameter. In vivo PMMA markers 3.0 mm in diameter and barium-impregnated silicone rubber spheres 2 mm in diameter were used. The best results were obtained with the barium-impregnated silicone rubber spheres both in vitro and in vivo. For the CT-delineation of selected uveal melanomas with either a flat discoid shape or flat tumour extensions or when adjacent serous retinal detachment is present, small episclerally sutured barium-impregnated silicone rubber spheres are useful as localizers for determining the clinical tumour volume.
authors.affiliation: Department of Ophthalmology, University Hospital of Vienna, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Zehetmayer
authors.forename: W
authors.initials: W
authors.lastname: Schima
authors.forename: R
authors.initials: R
authors.lastname: Menapace
authors.forename: K
authors.initials: K
authors.lastname: Kitz
authors.forename: W
authors.initials: W
authors.lastname: Radner
authors.forename: K
authors.initials: K
authors.lastname: Dieckmann
mesh_terms: D006801:Humans; D007089:Image Enhancement; D008545:Melanoma / Q000000981:diagnostic imaging*; D008670:Metals; D019904:Polymethyl Methacrylate; D013238:Stereotaxic Techniques; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014604:Uveal Neoplasms / Q000000981:diagnostic imaging*
chemical_list: D008670:Metals; D019904:Polymethyl Methacrylate