Evidence for the genetic basis of non-response in mice.
In the murine model the immune response to both the hepatitis B envelope and nucleocapsid antigens are linked to the MHC class II haplotype but they are independently restricted. Although in a human outbred population non-response is less likely, the host genetic environment may be important in determining the level of response to vaccine and inclusion of antigens apart from the S antigen may improve protection. The inclusion of HBcAg in vaccine remains controversial since, despite its high immunogenicity, the Th-cell response to this antigen may have a role in the down regulation of the immune response to HBV so promoting persistence.
Waters
J A
JA
Department of Medicine, Imperial College School of Medicine, London, UK.
D000818:Animals; D006509:Hepatitis B / Q000517:prevention & control*; D006512:Hepatitis B Core Antigens / Q000235:genetics* / Q000276:immunology; D006514:Hepatitis B Surface Antigens / Q000235:genetics* / Q000276:immunology; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006515:Hepatitis B virus / Q000276:immunology*; D051379:Mice
D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines