Reactivity and suitability of t-Boc-protected thiophosphotyrosine intermediate analogs for the solid or solution phase peptide synthesis.
N-(tert-Butoxycarbonyl)-O-(dimethylthiophosphono)-L-tyrosine (6) and N-(tert-butoxycarbony)-O-(dicyanoethylthiophosphono)-L-tyros ine (15) were prepared as intermediates for the synthesis of thiophosphotyrosine-containing peptides. The reactivity and suitability of two compounds for the solid phase or solution phase peptide synthesis utilizing t-Boc chemistry were examined.
Kim
E K
EK
College of Pharmacy, Yeungnam University, Kyongsan, Korea.
Choi
H
H
Lee
E S
ES
D007202:Indicators and Reagents; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D010455:Peptides / Q000138:chemical synthesis*; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
D007202:Indicators and Reagents; D009943:Organophosphorus Compounds; D010455:Peptides; D014443:Tyrosine