Dysregulation of trace element composition in ovariectomized cynomolgus monkey bones.
One of the challenging issues in modern biomedical science is the increasing number of osteoporosis patients due to the expansion of elderly populations. Among aging-related pathogenic changes, alterations in bone function and skeletal pathogenesis is a particularly important issue of concern. Osteoporosis is one of the most serious bone-related pathogenic states, as it causes serious loss of quality of life. Alterations in estrogen levels in accordance with aging are one of the key risk factors for osteoporosis. Complexed estrogen actions on bones can be traced by analyzing bone mineral components, as those elements accumulate as mineral complexes, reflecting the context of multiple cellular reactions such as bone resorption/osteogenesis. We have analyzed bone trace element composition in ovariectomized (OVX-treated) Cynomolgus monkey models in this study. In order to gain insights into the effects of such defects on bone trace element composition, inductively coupled plasma atomic emissions spectrometry (ICP-AES) analysis was performed. Marked changes in bone trace element levels were found in vertebral bones of OVX-treated Cynomolgus monkeys. An assessment of these trace element spectra in OVX model animals is discussed. These results could provide useful markers for understanding the physiological states of bones in postmenopausal women.
Yamada
G
G
Nakamura
S
S
Fukuzaki
K
K
Izumi
H
H
Horai
N
N
Nagata
R
R
Minami
T
T
Tohno
Y
Y
Suzuki
K
K
Haraguchi
R
R
Miyado
K
K
Toyoda
T
T
Izpisua-Belmonte
J C
JC
Maruyama
I
I
Kitajima
I
I
D000818:Animals; D001835:Body Weight; D015519:Bone Density; D002118:Calcium / Q000378:metabolism; D004195:Disease Models, Animal; D004958:Estradiol / Q000097:blood; D005260:Female; D008252:Macaca fascicularis; D008274:Magnesium / Q000378:metabolism; D010024:Osteoporosis / Q000378:metabolism*; D010052:Ovariectomy; D010053:Ovary / Q000502:physiology*; D010758:Phosphorus / Q000378:metabolism; D012825:Silicon / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D013053:Spectrophotometry; D013131:Spine / Q000378:metabolism*; D013455:Sulfur / Q000378:metabolism; D014131:Trace Elements / Q000378:metabolism*; D015032:Zinc / Q000378:metabolism
D014131:Trace Elements; D010758:Phosphorus; D004958:Estradiol; D013455:Sulfur; D012964:Sodium; D008274:Magnesium; D015032:Zinc; D002118:Calcium; D012825:Silicon