UV spectroscopy study on complexes of phosphonate ApA analogs with poly(U): promising step in prediction of oligonucleotide analog properties?
The isopolar nonisosteric phosphonate analogs of ApA differing in the position of extra methylene group introduced into the sugar-phosphate backbone, featuring both possible 2',5'- and 3',5'- pairs as well as their conformationally restricted congeners, were investigated for their ability to form complexes with polyU. The results may lead to the specification of candidates for synthesis of novel oligonucleotides.
Pressová
M
M
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague.
Endová
M
M
Toĉík
Z
Z
Liboska
R
R
Rosenberg
I
I
D000225:Adenine; D015226:Dinucleoside Phosphates / Q000737:chemistry*; D007700:Kinetics; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000737:chemistry*; D063065:Organophosphonates; D011072:Poly U / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship; D013816:Thermodynamics
D015226:Dinucleoside Phosphates; D009841:Oligonucleotides; D063065:Organophosphonates; D011072:Poly U; D000225:Adenine