A new indole derivative from the red alga Chondria atropurpurea. Isolation, structure determination, and anthelmintic activity.
Chondriamide C (3), a new bis(indole) amide, was isolated from the red alga Chondria atropurpurea, and its structure was established from spectroscopic data and chemical transformations. A new natural product, 3-indoleacrylamide (4), and the previously described chondriamides A and B (1, 2) and 3-indoleacrylic acid (5) were also isolated. The anthelmintic activities of compounds 1, 3, 4, and 6 (the O,N1,N1'-trimethyl derivative of compound 2) against Nippostrongylus brasiliensis in vitro were evaluated.
Davyt
D
D
Facultad de Química, Universidad de la República, Av. Gral. Flores, 2124 Montevideo, Uruguay.
Entz
W
W
Fernandez
R
R
Mariezcurrena
R
R
Mombrú
A W
AW
Saldaña
J
J
Domínguez
L
L
Coll
J
J
Manta
E
E
D015766:Albendazole / Q000494:pharmacology; D000818:Animals; D000871:Anthelmintics / Q000302:isolation & purification* / Q000494:pharmacology; D007211:Indoles / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009559:Nippostrongylus / Q000187:drug effects; D000461:Rhodophyta / Q000737:chemistry*; D013055:Spectrophotometry, Infrared
D000871:Anthelmintics; D007211:Indoles; C117238:chondriamide C; D015766:Albendazole