Effect of desogestrel-containing oral contraceptives on vascular reactivity and catecholamine levels.
The modifications induced by new oral contraceptives (OC) on blood pressure, great vessel vascular reactivity by color Doppler, and catecholamine levels were investigated. Young healthy women not taking OC (n = 22; controls) or receiving, for > or = 6 months, OC containing desogestrel with either 30 micrograms (n = 14) or 20 micrograms of EE (n = 8) were enrolled. Blood pressure measured at rest in supine position was similar between controls and OC users. The pulsatility index (PI), an indirect index of resistance to blood flow, of axillary artery was significantly higher (p < 0.05) in 30 micrograms than in 20 micrograms EE OC users or controls. A similar trend, albeit not significant, was observed for the internal carotid artery PI. Norepinephrine (p < 0.01) and dopamine (p < 0.05) but not epinephrine levels, were lower in 30 micrograms EE OC users than in 20 micrograms EE OC users or controls. Thus, both 20 micrograms and 30 micrograms EE OC had no negative effect on blood pressure, but the 30 micrograms EE OC tended to increase great vessel resistance to blood flow, independently of catecholamine levels.
Arangino
S
S
Institute of Obstetrics and Gynecology, Modena, Italy.
Cagnacci
A
A
Angiolucci
M
M
Longu
G
G
Melis
G B
GB
Volpe
A
A
D000328:Adult; D000704:Analysis of Variance; D001783:Blood Flow Velocity; D001794:Blood Pressure / Q000187:drug effects*; D016022:Case-Control Studies; D002851:Chromatography, High Pressure Liquid; D003280:Contraceptives, Oral, Synthetic / Q000494:pharmacology*; D017135:Desogestrel / Q000494:pharmacology*; D004298:Dopamine / Q000097:blood*; D004837:Epinephrine / Q000097:blood; D005260:Female; D006339:Heart Rate; D006801:Humans; D009638:Norepinephrine / Q000097:blood*; D018615:Ultrasonography, Doppler, Color; D014655:Vascular Resistance / Q000187:drug effects*
D003280:Contraceptives, Oral, Synthetic; D017135:Desogestrel; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine