title: Calcipotriol toxicity in a dog.
abstract: A six-month-old Labrador retriever was presented for investigation of acute polyuria, polydipsia and haematemesis six hours following ingestion of a tube of the topical antipsoriatic vitamin D analogue, calcipotriol. Transient hypercalcaemia, azotaemia, proteinuria, thrombocytopenia and ventricular arrhythmias ensued. Abdominal ultrasonography and echocardiography revealed evidence of diffuse soft tissue mineralisation. Despite 13 days of intensive supportive care, the dog was euthanased due to continued haematemesis and anorexia. Necropsy confirmed mineralisation and necrosis of multiple organ systems consistent with vitamin D toxicity.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14583, USA.
authors.forename: T M
authors.initials: TM
authors.lastname: Fan
authors.forename: K W
authors.initials: KW
authors.lastname: Simpson
authors.forename: S
authors.initials: S
authors.lastname: Trasti
authors.forename: N
authors.initials: N
authors.lastname: Birnbaum
authors.forename: S A
authors.initials: SA
authors.lastname: Center
authors.forename: A
authors.initials: A
authors.lastname: Yeager
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D002114:Calcinosis / Q000209:etiology / Q000662:veterinary*; D002117:Calcitriol / Q000031:analogs & derivatives* / Q000506:poisoning; D003879:Dermatologic Agents / Q000506:poisoning*; D004283:Dog Diseases / Q000139:chemically induced*; D004285:Dogs; D006934:Hypercalcemia / Q000139:chemically induced; D008297:Male; D009336:Necrosis; D011507:Proteinuria / Q000139:chemically induced; D013921:Thrombocytopenia / Q000139:chemically induced; D014511:Uremia / Q000139:chemically induced
chemical_list: D003879:Dermatologic Agents; C055085:calcipotriene; D002117:Calcitriol