title: [Treatment with omeprazole, clarithromycin and amoxicillin for one week. Their efficacy and tolerance in eradicating Helicobacter pylori in primary care].
abstract: OBJECTIVE
  To study the effectiveness and tolerance of the combination of omeprazole, clarithromycin and amoxycillin taken for a week on the eradication of Helicobacter pylori (HP) in patients with peptic ulcer and symptomatic chronic gastritis.
  
  
  METHODS
  Intervention study.
  
  
  METHODS
  Urban health centre.
  
  
  METHODS
  121 patients, diagnosed by fiber gastroscopy and with an HP infection demonstrated by the urease test, breath test, serology or biopsy, were studied prospectively. 13 suffered from a gastric ulcer, 54 from duodenal ulcer and 54 from chronic gastritis. Two patients stopped treatment because of side-effects, but were included in the study (analysis by treatment intention).
  
  
  METHODS
  The combination of omeprazole (20 mg/12 hours), amoxycillin (1 gr/12 hours) and clarithromycin (500 mg/12 hours) was administered for a week. No medication was prescribed afterwards. Therapeutic compliance (count of tablets and interview) and side-effects were systematically evaluated. Four to eight weeks later patients took a breath test with Urea C14 to confirm eradication.
  
  
  RESULTS
  Average age was 47 (SD 14.5); 54% were women. Eradication was confirmed in 80.2% of cases (CI 95%; 73.1-87.3). Side-effects were light or moderate in all cases: the most common were dysgeusia (67%), nausea (18%) and diarrhoea (17%).
  
  
  CONCLUSIONS
  The triple therapy of omeprazole, amoxycillin and clarithromycin for a week is efficacious in eradicating HP. It is extremely easy to apply, and there are few relevant side-effects.
authors.affiliation: Area Básica de Salud (ABS) Carles Ribas, Barcelona.
authors.forename: J M
authors.initials: JM
authors.lastname: Baena Díez
authors.forename: A
authors.initials: A
authors.lastname: Sancho Perpiñán
authors.forename: C
authors.initials: C
authors.lastname: López Mompó
authors.forename: F
authors.initials: F
authors.lastname: Rams Rams
authors.forename: S
authors.initials: S
authors.lastname: Jiménez Navarrete
authors.forename: D
authors.initials: D
authors.lastname: Comet Jaumet
mesh_terms: D000658:Amoxicillin / Q000008:administration & dosage* / Q000009:adverse effects; D017291:Clarithromycin / Q000008:administration & dosage* / Q000009:adverse effects; D004359:Drug Therapy, Combination; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000008:administration & dosage* / Q000009:adverse effects; D010349:Patient Compliance; D011320:Primary Health Care / Q000379:methods*; D011446:Prospective Studies; D012074:Remission Induction; D013997:Time Factors
chemical_list: D000658:Amoxicillin; D017291:Clarithromycin; D009853:Omeprazole