title: [Cooling action of topicals--present results and testing methods in vivo and in vitro].
abstract: The cooling effect of topicals has been used in the dermatological therapy as "physical effect" on the skin for more than hundred years. This effect of dermatologicals releasing free water is widely accepted, but current knowledge does not correspond to today's possibilities of experimental thermographic tests in man. The present paper describes the results published up to now and the current testing methods in vivo and in vitro.
authors.affiliation: Sowie Lehrstuhl für Pharmazeutische Technologie der Ludwig-Maximilians-Universität, München, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Thoma
authors.forename: H C
authors.initials: HC
authors.lastname: Korting
authors.forename: E
authors.initials: E
authors.lastname: Thoma-Greber
mesh_terms: D000818:Animals; D003879:Dermatologic Agents / Q000494:pharmacology*; D006801:Humans; D012867:Skin / Q000187:drug effects* / Q000503:physiopathology; D013696:Temperature; D013821:Thermometers; D014867:Water
chemical_list: D003879:Dermatologic Agents; D014867:Water