Effects of repeated clarithromycin administration on the pharmacokinetic properties of pindolol in rats.
The goal of the present work was to determine the effect of clarithromycin (CAM) administration on the pharmacokinetic properties of pindolol in rats. The binding of pindolol to serum components increases proportionally with increasing alpha1-acid glycoprotein (AGP) concentration, indicating that AGP might play a major role in the binding of pindolol. After intravenous administration of pindolol to rats, the CAM-treated group showed a decrease in the volume of distribution, an increase in AUC and no change in the half-life as compared to the control group. Treatment with CAM increased the AGP concentration only. The serum concentration of albumin and creatinine, as well as the metabolic activity of hepatic microsomes towards pindolol, were not altered. Good correlation was observed between the AUC of pindolol in rats and the AGP concentration in serum. Moreover, at 5 min after the administration of an intravenous bolus dose of pindolol to CAM-treated rats, the free concentration of pindolol was lower but the total concentration was higher, compared with the control rats. These results suggested that the influence of CAM on the pharmacokinetic properties of pindolol in CAM-treated rats can be explained by protein binding which, in turn, may be associated with variations in AGP concentration.
Komori
T
T
Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
Shimoishi
K
K
Harashima
H
H
Otagiri
M
M
D000319:Adrenergic beta-Antagonists / Q000378:metabolism / Q000493:pharmacokinetics*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D019540:Area Under Curve; D001798:Blood Proteins / Q000378:metabolism; D017291:Clarithromycin / Q000494:pharmacology*; D004347:Drug Interactions; D008297:Male; D010869:Pindolol / Q000378:metabolism / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar
D000319:Adrenergic beta-Antagonists; D000900:Anti-Bacterial Agents; D001798:Blood Proteins; D010869:Pindolol; D017291:Clarithromycin