Curacin D, an antimitotic agent from the marine cyanobacterium Lyngbya majuscula.
Curacin D is a novel brine shrimp toxic metabolite isolated from a Virgin Islands collection of the marine cyanobacterium Lyngbya majuscula. Structure elucidation of curacin D was accomplished through multidimensional NMR, GC/MS, and comparisons with curacin A. Curacin D provides new insights into structure-activity relationships in this natural product class as well as some aspects of the likely biosynthetic pathway of the curacins.
Márquez
B
B
College of Pharmacy, Oregon State University, Corvallis 97331, USA.
Verdier-Pinard
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P
Hamel
E
E
Gerwick
W H
WH
D000458:Cyanobacteria / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008938:Mitosis / Q000187:drug effects*; D015394:Molecular Structure; D013844:Thiazoles / Q000737:chemistry / Q000302:isolation & purification*; D014407:Tumor Cells, Cultured
D013844:Thiazoles; C116945:curacin D