[Familial medullary carcinoma of the thyroid. The usefulness of ultrasonography and Doppler color].
Medullary carcinoma of the thyroid (MCT) is an uncommon malignant neoplasm, which occurs sporadically and in three familial syndromes with a dominant autosomal transmission mode. We studied a family of 13 members in which four of them (two males and two females: sons, mother and niece) were involved with MCT. All of them underwent mode-B echography and colour-Doppler echography and pulsed colour Doppler, with measurement of carcinoembryonic antigen (CEA) and calcitonin, in an attempt to delineate a pattern useful to differentiate malignant from benign thyroid pathology. Colour Doppler signal was of little usefulness for histologic characterization in function of vascularization, although it was useful for delineating nodules in non-homogeneous glands.
Fernández García
P
P
Servicio de Radiodiagnóstico, Hospital General, Castellón.
Cervera Deval
J
J
Marco Doménech
S F
SF
Laguna Sastre
M
M
D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood; D001707:Biopsy, Needle; D002116:Calcitonin / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000097:blood; D018276:Carcinoma, Medullary / Q000097:blood / Q000000981:diagnostic imaging* / Q000235:genetics* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013961:Thyroid Gland / Q000000981:diagnostic imaging / Q000473:pathology; D013964:Thyroid Neoplasms / Q000097:blood / Q000000981:diagnostic imaging* / Q000235:genetics* / Q000473:pathology; D018615:Ultrasonography, Doppler, Color
D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D002116:Calcitonin