The pharmacokinetics of ibuprofen suspension, chewable tablets, and tablets in children with cystic fibrosis.
OBJECTIVE
The objectives of this study were to compare the pharmacokinetic parameters of ibuprofen administered as a suspension, chewable tablet, or tablet in children with cystic fibrosis and to determine the optimal blood sampling times for measuring ibuprofen peak concentrations.


METHODS
A single oral 20 mg/kg dose of ibuprofen was administered, and blood samples were obtained at 15, 30, 45, 60, 120, 240, and 360 minutes after the dose was administered. Peak plasma concentration (Cmax ), time to peak concentration (Tmax ), and other pharmacokinetic parameters were determined and compared (analysis of variance and analysis of covariance).


RESULTS
Thirty-eight children were included (22, 4, and 12 in the suspension, chewable tablet, and tablet groups, respectively). Tmax was the only parameter for which statistical differences were noted (suspension vs tablet, P </=.02). After age and sex were removed as potential confounding variables, Tmax remained statistically different (P </=.001).


CONCLUSIONS
A 20 mg/kg dose of ibuprofen suspension is recommended, with blood samples for pharmacokinetic analysis obtained 30, 45, and 60 minutes after the dose is administered. Obtaining the first blood sample 1 hour after dose administration will miss approximately 90% of peak concentrations, increasing the likelihood of overdosing.
Scott
C S
CS
School of Pharmacy, Division of Pharmacotherapy and Drug Development, The University of North Carolina at Chapel Hill, 27599-7360, USA.
Retsch-Bogart
G Z
GZ
Kustra
R P
RP
Graham
K M
KM
Glasscock
B J
BJ
Smith
P C
PC
D000284:Administration, Oral; D000293:Adolescent; D000704:Analysis of Variance; D019540:Area Under Curve; D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid; D003550:Cystic Fibrosis / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D012129:Respiratory Function Tests; D013535:Suspensions; D013607:Tablets
D013535:Suspensions; D013607:Tablets; D007052:Ibuprofen