title: Intracranial leiomyosarcoma: a neuro-oncological consequence of acquired immunodeficiency syndrome.
abstract: Leiomyosarcoma has recently been identified as an AIDS-related tumor, usually occurring in children in the chest or abdomen. We describe a case of intracranial leiomyosarcoma in an adult with AIDS. An enhancing mass adjacent to the right occipital cortical surface was diagnosed during a work-up for left arm weakness. Imaging characteristics were suggestive of a malignant neoplasm versus meningioma. The patient had a craniotomy for total excision of the lesion. Pathology showed a leiomyosarcoma. Metastatic work-up was negative. The patient refused radiation therapy, but is well without evidence of recurrence at 8 months follow-up. The differential diagnosis for intracranial lesions in AIDS should be expanded to include leiomyosarcoma. Surgical resection of the lesion is recommended.
authors.affiliation: Division of Neurosurgery, University of Massachusetts Medical School, Worcester 01655, USA. scott.litofsky@banyan.ummed.edu
authors.forename: N S
authors.initials: NS
authors.lastname: Litofsky
authors.forename: G
authors.initials: G
authors.lastname: Pihan
authors.forename: F
authors.initials: F
authors.lastname: Corvi
authors.forename: T W
authors.initials: TW
authors.lastname: Smith
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D001932:Brain Neoplasms / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007890:Leiomyosarcoma / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed