title: How precisely do SPECT images reflect tracer uptake in myocardial infarction? A comparison of thallium-201 and technetium-99m using a myocardial phantom.
abstract: OBJECTIVE
  We compared the count ratios of 201TI and 99mTc on SPECT images and the true radioactivity in a myocardial phantom to study how precisely SPECT images reflect tracer uptake in myocardial infarction.
  
  
  METHODS
  A defect with 20%, 40% or 60% of normal myocardial radioactivity was placed in the anterior or inferior wall of a myocardial phantom to simulate myocardial infarction. Lung radioactivity was kept at 10% or 30% of normal myocardial radioactivity. The count ratio on short-axis SPECT images was calculated using the circumferential profile curve analysis.
  
  
  RESULTS
  The count ratios of 201TI and 99mTc SPECT images with an anterior wall defect was lower than the true radioactivity in the phantom. The count ratio on SPECT images with the inferior wall defect was greater than the true radioactivity for the 20% and 40% defects and lower for the 60% defect.
  
  
  CONCLUSIONS
  SPECT images overestimated decreased perfusion in the anterior wall. SPECT images underestimated decreased perfusion for 20% and 40% perfusion defects in the inferior wall.
authors.affiliation: Department of Radiological Technology, School of Health Sciences, Faculty of Medicine, Kanazawa University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Onoguchi
authors.forename: H
authors.initials: H
authors.lastname: Maruno
authors.forename: T
authors.initials: T
authors.lastname: Takayama
authors.forename: H
authors.initials: H
authors.lastname: Murata
mesh_terms: D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D009203:Myocardial Infarction / Q000000981:diagnostic imaging*; D019047:Phantoms, Imaging; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D013667:Technetium; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019275:Radiopharmaceuticals; D013794:Thallium Radioisotopes; D013667:Technetium