title: Aneurysmal bone cyst: its pathogenesis based on angiographic, immunohistochemical and electron microscopic studies.
abstract: Based on angiographic, immunohistochemical as well as electron microscopic findings, authors outline a hypothesis for the etiopathogenesis of aneurysmal bone cysts. No changes were found at the arterial site in 16 studied aneurysmal bone cysts, with no signs of an arteriovenous shunt. In certain cases, however, dilated and tortous efferent veins became visible in the late venous phase. Due to the impedance of venous flow, the intracystic pressure increases and the small veins become dilated causing formation of aneurysmal slits. This is supported by the immunohistochemical finding that S-actin shows concentric arrangement around the aneurysmal cavities. Endothelial lining and basal membrane remnants were detectable in places, though the aneurysmal slits were devoid of continuous endothelial lining and basal membrane. We suggested that the aneurysmal bone cyst corresponds to a hemodynamic disturbance and is due to primary or secondary venous malformation of the bones.
authors.affiliation: Department of Orthopaedics, Semmelweis University of Medicine, Budapest, Hungary.
authors.forename: M
authors.initials: M
authors.lastname: Szendroi
authors.forename: G
authors.initials: G
authors.lastname: Arató
authors.forename: A
authors.initials: A
authors.lastname: Ezzati
authors.forename: K
authors.initials: K
authors.lastname: Hüttl
authors.forename: P
authors.initials: P
authors.lastname: Szavcsur
mesh_terms: D000199:Actins / Q000032:analysis; D000293:Adolescent; D000328:Adult; D017824:Bone Cysts, Aneurysmal / Q000098:blood supply / Q000737:chemistry / Q000209:etiology* / Q000473:pathology; D001842:Bone and Bones / Q000098:blood supply; D002648:Child; D003094:Collagen / Q000032:analysis; D004108:Dilatation, Pathologic / Q000209:etiology; D018056:Hemorheology; D006801:Humans; D007124:Immunoenzyme Techniques; D014680:Veins / Q000002:abnormalities / Q000473:pathology; D014746:Vimentin / Q000032:analysis
chemical_list: D000199:Actins; D014746:Vimentin; D003094:Collagen