[Mechanism of the etiology of dyspeptic disorders during the period of primary reaction after exposure to high-dose ionizing radiation].
The experiments with dogs exposed to accelerated electrons at a dose of 100 Gy have confirmed an important role of the central mechanism of early post-radiation dyspepsia which is realized through the excitation of receptors in the mechanism of postradiation gastrointestinal disturbance, alongside biogenic amines, prostaglandins also play a certain role. Studies on the effect of a prostaglandin biosynthesis blocker--dexamethasone, a corticosteroid--on post-radiation dyspepsia provide evidence that investigation of prostaglandin biosynthesis inhibitors with a mechanism different from that of dexamethasone is appropriate.
Martirosov
K S
KS
State Research Center of Russia, Institute of Biophysics, Moscow.
Grigor'ev
Iu G
IuG
Zorin
V V
VV
Iashkin
P N
PN
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000932:Antiemetics / Q000627:therapeutic use; D001549:Benzamides / Q000627:therapeutic use; D003907:Dexamethasone / Q000627:therapeutic use; D004285:Dogs; D018492:Dopamine Antagonists / Q000627:therapeutic use; D004415:Dyspepsia / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D008297:Male; D011448:Prostaglandin Antagonists / Q000627:therapeutic use; D011453:Prostaglandins / Q000502:physiology; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000188:drug therapy / Q000503:physiopathology; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D000932:Antiemetics; D001549:Benzamides; D018492:Dopamine Antagonists; D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D003907:Dexamethasone; C037141:dimetpramid