[Quality of life and cytokines in oncological therapy].
The development of the hematopoietic growth-factors had a major influence on the treatment of malignant diseases. Quality of Life gets increasingly important in the setting of high-dose chemotherapy and stem cell transplantation. Granulocyte-colony stimulating factor (G-CSF) and erythropoietin (EPO) are two of the most important hematopoietic growth-factors, which contribute to the amelioration of the complications of the malignant disease and the side-effects of the cytostatic treatment. G-CSF reduces the median time of neutrophil recovery, the rate of severe infections and the length of hospitalization. Erythropoietin has a beneficial impact on the quality of life of cancer patients by improving the chronic anemia of cancer, leading to a higher level of physical and social activity, brighter mood, improvement of appetite and general sense of well-being.
Leitgeb
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I. Medizinischen Abteilung mit Onkologie, Wilhelminenspitals der Stadt Wien. clemens.leitgeb@1me.wil.magwien.gv.at
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004921:Erythropoietin / Q000008:administration & dosage*; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D011788:Quality of Life; D011994:Recombinant Proteins
D011994:Recombinant Proteins; D004921:Erythropoietin; D016179:Granulocyte Colony-Stimulating Factor