title: A major influence of sex-specific loci on alcohol preference in C57Bl/6 and DBA/2 inbred mice.
abstract: C57Bl/6 mice reproducibly prefer to ingest more 10% ethanol in a two-bottle choice paradigm than do DBA/2J mice. In this paper we report the identification of two new sex-specific alcohol preference (Alcp) loci. Melo and associates (1996) identified two loci: Alcp1, a male-specific locus on Chromosome (Chr) 2, and Alcp2, a female- and cross-specific locus on Chr 11. We have additionally identified Alcp3, a male-specific locus on Chr 3, and Alcp4, a female-specific locus on Chr 1. We have also performed a statistical analysis to exclude the possibility of undiscovered major alcohol preference loci that are not sex-specific in our backcross paradigm. Our results indicate that alcohol preference in C57BL/6 mice, as measured in our backcross, is largely controlled in a sex-specific manner.
authors.affiliation: Princeton University, Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.
authors.forename: J L
authors.initials: JL
authors.lastname: Peirce
authors.forename: R
authors.initials: R
authors.lastname: Derr
authors.forename: J
authors.initials: J
authors.lastname: Shendure
authors.forename: T
authors.initials: T
authors.lastname: Kolata
authors.forename: L M
authors.initials: LM
authors.lastname: Silver
mesh_terms: D000428:Alcohol Drinking / Q000235:genetics*; D000818:Animals; D002874:Chromosome Mapping; D002875:Chromosomes / Q000235:genetics; D003433:Crosses, Genetic; D004843:Epistasis, Genetic; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D019655:Quantitative Trait, Heritable; D012737:Sex Factors