Combined effect of CDDP and caffeine against human gastric cell line in vivo.
This study was conducted to clarify the enhancement of the anti-tumor effect of CDDP by caffeine using a tumor-bearing peritoneal disseminated metastasis model in vivo. To evaluate the combined effect of CDDP and caffeine on the survival in vivo, nude mice bearing STKM-1 gastric cancer cells were administered CDDP alone, caffeine alone, or in both combination intraperitoneally. Treatment was started from 8 days after tumor inoculation. The combination of CDDP and caffeine more markedly prolonged the survival time than CDDP alone or caffeine alone. In conclusion, the results of the present in vivo study suggest that clinical application of caffeine in combination with CDDP might be effective against peritoneal disseminated metastasis in gastric cancer patients.
Takahashi
M
M
First Department of Surgery, Yokohama City University, School of Medicine, Japan.
Yanoma
S
S
Yamamoto
Y
Y
Rino
Y
Y
Amano
T
T
Imada
T
T
D000230:Adenocarcinoma / Q000188:drug therapy*; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002110:Caffeine / Q000627:therapeutic use*; D002945:Cisplatin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D013274:Stomach Neoplasms / Q000188:drug therapy*; D016019:Survival Analysis; D013997:Time Factors; D014183:Transplantation, Heterologous; D014407:Tumor Cells, Cultured
D002110:Caffeine; D002945:Cisplatin