Vitamin A functions in the regulation of the dopaminergic system in the brain and pituitary gland.
Retinoic acids, bound to their receptors, function in the brain and pituitary gland by regulating the expression of the dopamine receptor D2R, which is a component of the dopaminergic system. The liganded retinoic acid receptors are specific transcription factors that are essential for full expression of D2R. D2R-knockout mice lack these retinoic acid receptors and exhibit a defect in locomotor ability similar to that seen in Parkinson's disease.
Wolf
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Department of Nutritional Sciences, University of California, Berkeley 94720-3104, USA.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D010902:Pituitary Gland / Q000378:metabolism*; D017448:Receptors, Dopamine D2 / Q000235:genetics* / Q000502:physiology; D018168:Receptors, Retinoic Acid / Q000502:physiology; D014801:Vitamin A / Q000502:physiology*
D017448:Receptors, Dopamine D2; D018168:Receptors, Retinoic Acid; D014801:Vitamin A