[Factors related with compliance with tuberculosis chemoprophylaxis].
OBJECTIVE
To determine therapeutic tolerance and compliance level with antituberculous chemoprophylaxis.


METHODS
587 patients were proposed for antituberculous chemoprophylaxis with isoniazid from January 1995 to June 1996 in Murcia (Spain).


RESULTS
3.6% of the patients gave up treatment because of hepatic intolerance and 73% completed the prophylaxis. Non-compliance related factors were: social risk factors (odds ratio [OR] = 9.31), previous history of allergies (OR = 2.87), previous personal history of tuberculosis-related events (OR = 0.49) and interaction between sex and age.


CONCLUSIONS
Support and intervention measures directed to risk groups of a social origin deem to be needed. Control measures and information provided to middle-aged males, with particular emphasis to the first weeks of prophylaxis, should also be implemented.
Galvañ Olivares
F
F
Centro de Prevención y Control de la Tuberculosis, Consejería de Sanidad y Política Social de Murcia.
Santiuste de Pablos
C
C
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000995:Antitubercular Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance / Q000706:statistics & numerical data*; D017678:Sex Distribution; D014376:Tuberculosis / Q000517:prevention & control*
D000995:Antitubercular Agents