The importance of cerebrospinal fluid lactate in the evaluation of congenital lactic acidosis.
In 27 of 28 children with congenital lactic acidosis, cerebrospinal fluid lactate was higher than venous blood lactate. The mean +/- SEM difference between these variables was 2.4 +/- 0.3 mmol/L (P =.0001). Girls or patients with pyruvate dehydrogenase deficiency had higher cerebrospinal fluid lactate concentrations than boys or patients with respiratory chain defects or mitochondrial DNA mutations.
Stacpoole
P W
PW
Departments of Medicine (Division of Endocrinology and Metabolism), University of Florida, College of Medicine, Gainesville, USA.
Bunch
S T
ST
Neiberger
R E
RE
Perkins
L A
LA
Quisling
R
R
Hutson
A D
AD
Greer
M
M
D000140:Acidosis, Lactic / Q000134:cerebrospinal fluid* / Q000151:congenital*; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004272:DNA, Mitochondrial / Q000235:genetics; D004579:Electron Transport; D005260:Female; D006801:Humans; D007223:Infant; D007773:Lactates / Q000097:blood / Q000134:cerebrospinal fluid*; D008297:Male; D009154:Mutation; D015325:Pyruvate Dehydrogenase Complex Deficiency Disease / Q000134:cerebrospinal fluid / Q000378:metabolism*
D004272:DNA, Mitochondrial; D007773:Lactates