Genetic linkage analysis of complex genetic traits by using affected sibling pairs.
We provide an introduction to genetic linkage analysis. We discuss methods for the genetic analysis of common, complex disease such as diabetes, heart disease or hypertension. We describe the analysis of affected sibling pairs and discuss some of the challenges in applying these methods.
Hauser
E R
ER
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA. bhauser@dnadoc.mc.duke.edu
Boehnke
M
M
D001699:Biometry / Q000379:methods*; D003920:Diabetes Mellitus / Q000235:genetics; D005260:Female; D008040:Genetic Linkage; D006331:Heart Diseases / Q000235:genetics; D006801:Humans; D006973:Hypertension / Q000235:genetics; D008297:Male; D009679:Nuclear Family; D010375:Pedigree