Frontosubcortical neuroanatomy and the continuous performance test in mania.
OBJECTIVE
The authors examined whether Continuous Performance Test scores correlate with frontosubcortical volumes in bipolar disorder.


METHODS
The subjects were 17 patients hospitalized for an acute manic episode and 12 group-matched comparison subjects. They underwent magnetic resonance imaging and completed the Continuous Performance Test.


RESULTS
The patients performed worse on the Continuous Performance Test and had smaller prefrontal cortical volumes than the comparison subjects. Within the patient group, Continuous Performance Test performance significantly correlated with prefrontal and hippocampal volumes.


CONCLUSIONS
These results suggest that certain neuroanatomic structures may be associated with attentional dysfunction in mania.
Sax
K W
KW
Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267-0559, USA. saxkw@email.uc.edu
Strakowski
S M
SM
Zimmerman
M E
ME
DelBello
M P
MP
Keck
P E
PE
Hawkins
J M
JM
D000293:Adolescent; D000328:Adult; D001288:Attention / Q000502:physiology; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000503:physiopathology; D001921:Brain / Q000033:anatomy & histology* / Q000503:physiopathology; D002421:Caudate Nucleus / Q000033:anatomy & histology / Q000503:physiopathology; D006624:Hippocampus / Q000033:anatomy & histology / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D017397:Prefrontal Cortex / Q000033:anatomy & histology* / Q000503:physiopathology; D013788:Thalamus / Q000033:anatomy & histology / Q000503:physiopathology