Hyaluronate-alginate combination for the preparation of new biomaterials: investigation of the behaviour in aqueous solutions.
With the aim of producing a biomaterial for surgical applications, the alginate-hyaluronate association has been investigated. Crossed techniques were used to assess the existence of polymer interactions in aqueous solutions up to 20 mg/ml. Alginate was obtained from algae and hyaluronate was purified from rooster comb. Viscometry measurements using the capillary technique or the Couette flow, together with circular dichroism investigations, evidenced the moderate significance of interactions between the two polysaccharides in dilute solutions. In addition, the case of more concentrated solutions and containing 20 mg/ml alginate was approached by rheological measurements in the flow mode; the behaviour of the polymer associations appeared as a compromise between those of individual polysaccharides.
Oerther
S
S
Physiopathologie et Pharmacologie Articulaires, Laboratoire de Pharmacologie, UMR 7561 CNRS-UHP Nancy 1 and FR CNRS W0070, Faculté de Médecine, BP 184, 54505, Vandoeuvre les Nancy cedex, France.
Payan
E
E
Lapicque
F
F
Presle
N
N
Hubert
P
P
Muller
S
S
Netter
P
P
D000464:Alginates / Q000737:chemistry* / Q000302:isolation & purification; D001672:Biocompatible Materials / Q000138:chemical synthesis*; D002942:Circular Dichroism; D006820:Hyaluronic Acid / Q000737:chemistry* / Q000302:isolation & purification; D011108:Polymers / Q000737:chemistry; D012212:Rheology; D012996:Solutions; D014783:Viscosity; D014867:Water
D000464:Alginates; D001672:Biocompatible Materials; D011108:Polymers; D012996:Solutions; D014867:Water; D006820:Hyaluronic Acid