title: Mitral valve replacement in Sickle C disease using intraoperative exchange transfusion.
abstract: Sickle C (SC) disease is a relatively uncommon hematologic disorder that poses special challenges when the patient requires a major surgical procedure. In particular, those who have a history of hemolytic crises require some type of intervention, usually homologous transfusion, to decrease the level of circulating hemoglobin S (HbS) and prevent intraoperative sickle crisis. We describe a 25-year-old man with SC disease and a history of multiple sickle cell crises who underwent mitral valve replacement using intraoperative exchange transfusion to decrease his HbS level from 53% to 7%.
authors.affiliation: Department of Surgery, Tulane Medical Center, New Orleans, Louisiana, USA.
authors.forename: A K
authors.initials: AK
authors.lastname: Madan
authors.forename: R S
authors.initials: RS
authors.lastname: Hartz
authors.forename: C
authors.initials: C
authors.lastname: Major
authors.forename: P
authors.initials: P
authors.lastname: McKee
authors.forename: L
authors.initials: L
authors.lastname: Flint
mesh_terms: D000328:Adult; D002315:Cardiopulmonary Bypass; D005078:Exchange Transfusion, Whole Blood / Q000379:methods*; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006450:Hemoglobin SC Disease / Q000150:complications; D006801:Humans; D007430:Intraoperative Care / Q000379:methods; D008297:Male; D008943:Mitral Valve; D008944:Mitral Valve Insufficiency / Q000150:complications / Q000601:surgery*