title: Antisocial personality disorder and alcohol-induced aggression.
abstract: This study compared the effects of alcohol on aggressive responding between subjects with antisocial personality disorder (ASPD) and subjects without ASPD. Eighteen alcohol drinking subjects (10 subjects without ASPD and 8 subjects with ASPD) underwent testing on a laboratory measure of aggression, the Point Subtraction Aggression Paradigm, after consumption of placebo and three doses of alcohol (0.25 g/kg, 0.5 g/kg, and 1.0 g/kg). There was a significant difference in the effect of alcohol on aggressive responding on the Point Subtraction Aggression Paradigm between subjects with ASPD and subjects without ASPD. Subjects with ASPD had a greater increase in aggressive responding after alcohol, compared with non-ASPD subjects. There was no difference between the two groups in the effect of alcohol on monetary-reinforced responding.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of Texas-Houston, Health Science Center, 77030, USA.
authors.forename: F G
authors.initials: FG
authors.lastname: Moeller
authors.forename: D M
authors.initials: DM
authors.lastname: Dougherty
authors.forename: S D
authors.initials: SD
authors.lastname: Lane
authors.forename: J L
authors.initials: JL
authors.lastname: Steinberg
authors.forename: D R
authors.initials: DR
authors.lastname: Cherek
mesh_terms: D000328:Adult; D000374:Aggression / Q000187:drug effects* / Q000523:psychology; D000428:Alcohol Drinking / Q000009:adverse effects / Q000523:psychology; D000435:Alcoholic Intoxication / Q000523:psychology*; D000987:Antisocial Personality Disorder / Q000175:diagnosis / Q000523:psychology*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009042:Motivation; D014754:Violence / Q000523:psychology
chemical_list: D000431:Ethanol