[Anticonvulsants can aggravate idiopathic generalized epilepsy].
Antiepileptic drugs can sometimes worsen idiopathic generalized epilepsies. Relevant data are based on empirical experience of epileptologists and on few published case-reports according to the suspected drug with serious methodological limitations. Some animal models of epileptic syndromes such as genetic models of absence seizures in rat seem to be helpful for understanding the possible mechanisms underlying drug-induced syndrome aggravation. Adequate epileptic syndrome diagnosis is needed before starting antiepileptic drug.
de Toffol
B
B
Clinique Neurologique, CHU Bretonneau, Tours.
Hommet
C
C
Corcia
P
P
Autret
A
A
D000818:Animals; D000927:Anticonvulsants / Q000009:adverse effects*; D002220:Carbamazepine / Q000009:adverse effects; D004195:Disease Models, Animal; D004831:Epilepsies, Myoclonic / Q000175:diagnosis / Q000188:drug therapy; D004832:Epilepsy, Absence / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology; D004829:Epilepsy, Generalized / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D009207:Myoclonus / Q000139:chemically induced; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D000927:Anticonvulsants; D002220:Carbamazepine; D005680:gamma-Aminobutyric Acid