title: [Pulmonary lymphangioleiomyomatosis (LAM). Diagnostic usefulness of immunohistochemical markers].
abstract: Lymphangioleiomyomatosis (LAM) is a rare disease of unknown cause affecting the lungs of female patients. Although clinical and radiological findings may suggest LAM, a firm diagnosis is usually made after lung biopsy. Cases of LAM (histochemical diagnosis) or "suggestive of LAM" at the "12 of October" Hospital are reviewed. We applied a battery of immunohistochemical tests not used to date--involving estrogen, progesterone, desmin and HMB45 receptors--that allowed us to classify specimens as having either LAM lesions or lesions with non-LAM muscle proliferation. Smooth muscle proliferation in LAM is a distinct phenotype, such that diagnosis is facilitated by analyzing for immunohistochemical markers such as HMB45. This marker can be detected on formalin-fixed paraffin-embedded sheets in specimens obtained by either open lung or transbronchial biopsy.
authors.affiliation: Departamento de Anatomía Patológica, Hospital Universitario 12 de Octubre, Madrid.
authors.forename: R
authors.initials: R
authors.lastname: Serrano Pardo
authors.forename: M T
authors.initials: MT
authors.lastname: Sotelo Rodríguez
authors.forename: C
authors.initials: C
authors.lastname: Alvarez Martínez
authors.forename: C
authors.initials: C
authors.lastname: Ballestin Carcavilla
authors.forename: E
authors.initials: E
authors.lastname: Larrú Cabrero
mesh_terms: D000328:Adult; D015415:Biomarkers; D001706:Biopsy; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008168:Lung / Q000473:pathology; D008171:Lung Diseases / Q000175:diagnosis* / Q000473:pathology; D018192:Lymphangioleiomyomatosis / Q000175:diagnosis* / Q000473:pathology; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed
chemical_list: D015415:Biomarkers