The S phase: beginning, middle, and end: a perspective.
Events in the S phase of the cell cycle have been investigated to a relatively limited extent in comparison with those in G1 and M phases. Four aspects of S are briefly discussed in this report: (1) the final biochemical step permitting initiation of DNA synthesis, (2) determination of replication timing of individual genes and its mechanism, (3) S phase processes that lead to the onset of M phase, and (4) resetting the S-phase machinery.
Ford
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HL
Dana-Farber Cancer Institute, Boston, Massachusetts 02115-6084, USA.
Pardee
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AB
D000818:Animals; D004261:DNA Replication; D020440:Gene Duplication; D006801:Humans; D008938:Mitosis / Q000235:genetics; D009369:Neoplasms / Q000235:genetics; D016196:S Phase / Q000235:genetics* / Q000502:physiology*