Hierridin B and 2,4-dimethoxy-6-heptadecyl-phenol, secondary metabolites from the cyanobacterium Phormidium ectocarpi with antiplasmodial activity.
Bioassay guided fractionation of the lipophilic extract of the marine cyanobacterium Phormidium ectocarpi yielded a new natural product hierridin B and the previously described compound 2,4-dimethoxy-6-heptadecyl-phenol. Both structures were secured by extensive spectroscopic analysis (1D and 2D NMR, MS, GC-MS, IR). The isolate (mixture) showed antiplasmodial activity towards Plasmodium falciparum.
Papendorf
O
O
Institute for Pharmaceutical Biology, Technical University of Braunschweig, Germany.
König
G M
GM
Wright
A D
AD
D000473:Alkanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000840:Anisoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000962:Antimalarials / Q000302:isolation & purification* / Q000494:pharmacology; D000458:Cyanobacteria / Q000737:chemistry*; D015394:Molecular Structure; D019800:Phenol / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013057:Spectrum Analysis
C113325:2,4-dimethoxy-6-heptadecylphenol; D000473:Alkanes; D000840:Anisoles; D000962:Antimalarials; C116944:hierridin B; D019800:Phenol