title: Lung cancer promotion by beta-carotene and tobacco smoke: relationship to suppression of retinoic acid receptor-beta and increased activator protein-1?
authors.forename: R
authors.initials: R
authors.lastname: Lotan
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000009:adverse effects* / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D001195:Asbestosis / Q000150:complications; D003043:Cocarcinogenesis; D015331:Cohort Studies; D015536:Down-Regulation; D005289:Ferrets; D005786:Gene Expression Regulation / Q000187:drug effects; D016762:Genes, fos; D016758:Genes, jun; D006801:Humans; D015994:Incidence; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000453:epidemiology / Q000209:etiology; D008679:Metaplasia; D010947:Plants, Toxic; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis / Q000235:genetics; D018168:Receptors, Retinoic Acid / Q000096:biosynthesis* / Q000235:genetics; D012906:Smoke / Q000009:adverse effects*; D012907:Smoking / Q000009:adverse effects; D014026:Nicotiana; D018808:Transcription Factor AP-1 / Q000502:physiology*; D014212:Tretinoin / Q000378:metabolism; D019207:beta Carotene / Q000009:adverse effects* / Q000494:pharmacology
chemical_list: D016588:Anticarcinogenic Agents; D000975:Antioxidants; D018809:Proliferating Cell Nuclear Antigen; D018168:Receptors, Retinoic Acid; D012906:Smoke; D018808:Transcription Factor AP-1; C082925:retinoic acid receptor beta; D019207:beta Carotene; D014212:Tretinoin