title: [A new class-III antiarrhythmic preparation among the dicyclohexylamides of aminocarboxylic acids].
abstract: The Institute of Pharmacology, Academy of Medical Sciences, jointly with AWD (Germany) has synthesized and tested a novel class III antiarrhythmic coded AWD-160-275, a derivative of dicyclohexylamides of aminocarboxylic acids. The compound was shown to prolong cardiac repolarization, to increase atrial and ventricular refractory periods, to decrease sinus nodal automatism, and to unchange intraventricular conduction. The compound proved to be superior to the reference drugs in the rate and duration of antiarrhythmic and antifibrillatory action. In therapeutical doses it has no antiarrhythmic effect. The specific feature of the agent is that there is no relation of longer effective refractory periods to the frequency of stimulation. This property may be useful in treating tachyarrhythmias.
authors.forename: N V
authors.initials: NV
authors.lastname: Kaverina
authors.forename: V V
authors.initials: VV
authors.lastname: Lyskovtsev
authors.forename: S F
authors.initials: SF
authors.lastname: Sokolov
authors.forename: H
authors.initials: H
authors.lastname: Poppe
authors.forename: D
authors.initials: D
authors.lastname: Marx
authors.forename: E P
authors.initials: EP
authors.lastname: Kishchuk
authors.forename: A I
authors.initials: AI
authors.lastname: Turilova
authors.forename: A M
authors.initials: AM
authors.lastname: Likhosherstov
authors.forename: I B
authors.initials: IB
authors.lastname: Tsorin
authors.forename: G G
authors.initials: GG
authors.lastname: Chichkanov
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000596:Amino Acids / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology; D002415:Cats; D003514:Cyclohexylamines / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D009200:Myocardial Contraction / Q000187:drug effects; D010210:Papillary Muscles / Q000187:drug effects / Q000502:physiology; D011817:Rabbits; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: C117100:AWD 160-275; D000596:Amino Acids; D000889:Anti-Arrhythmia Agents; D003514:Cyclohexylamines