Successful long-term treatment of congenital nephrogenic diabetes insipidus in a dog.
A two-year-old intact male shiba inu dog with excessive polyuria and polydipsia (PU-PD) was diagnosed as having congenital nephrogenic diabetes insipidus based on clinical findings, the results of urinalysis, blood examinations, a modified water deprivation test and a low dose dexamethasone suppression test. The owner was advised to provide adequate access to drinking water, and treatment with a low dose of hydrochlorothiazide (2 mg/kg, twice daily) together with a low sodium diet was initiated. As a result, the daily water intake decreased significantly from 6500 to 7500 ml/day (800 to 980 ml/kg/day) to 1400 to 1900 ml/day (170 to 230 ml/kg/day) and the clinical signs associated with the PU-PD and dehydration improved over the following two years.
Takemura
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Department of Veterinary Internal Medicine, Nippon Veterinary and Animal Science University, Tokyo, Japan.
D000818:Animals; D018500:Diabetes Insipidus, Nephrogenic / Q000188:drug therapy / Q000662:veterinary*; D004232:Diuretics; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004326:Drinking; D006852:Hydrochlorothiazide / Q000627:therapeutic use*; D008297:Male; D049993:Sodium Chloride Symporter Inhibitors / Q000627:therapeutic use*; D012982:Sodium, Dietary
D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D012982:Sodium, Dietary; D006852:Hydrochlorothiazide