Supraventricular arrhythmia: a complication of 5-fluorouracil therapy.
5-Fluorouracil is an S-phase-specific, synthetic pyrimidine antimetabolite, which is used as a cytostatic agent for a variety of malignant lesions, either singly or in multidrug regimens. Gastrointestinal toxicity and myelosuppression are the most common adverse reactions, but, of late, clinical cardiotoxicity has been reported in both prospective and retrospective studies. We present our experience of clinical cardiotoxicity in five patients.
Aziz
S A
SA
Sheri Kashmir Institute of Medical Sciences, Srinagar, India.
Tramboo
N A
NA
Mohi-ud-Din
K
K
Iqbal
K
K
Jalal
S
S
Ahmad
M
M
D000230:Adenocarcinoma / Q000188:drug therapy; D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D001146:Arrhythmia, Sinus / Q000139:chemically induced; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D001281:Atrial Fibrillation / Q000139:chemically induced; D001919:Bradycardia / Q000139:chemically induced; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D003110:Colonic Neoplasms / Q000188:drug therapy; D004938:Esophageal Neoplasms / Q000188:drug therapy; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects*; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012004:Rectal Neoplasms / Q000188:drug therapy; D013274:Stomach Neoplasms / Q000188:drug therapy; D013617:Tachycardia, Supraventricular / Q000139:chemically induced; D018879:Ventricular Premature Complexes / Q000139:chemically induced
D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil