Human MRP3 transporter: identification of the 5'-flanking region, genomic organization and alternative splice variants.
In humans, at least six members of the multidrug resistance-associated protein (MRP) family are thought to exist. Here we report the molecular cloning of two splice variants of MRP3 from human liver. In addition, MRP3 genomic organization including the 5'-flanking region and a major portion of the MRP3 intron-exon organization are identified and characterized.
Fromm
M F
MF
Division of Clinical Pharmacology, 572 Medical Research Bldg 1, Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232-6602, USA.
Leake
B
B
Roden
D M
DM
Wilkinson
G R
GR
Kim
R B
RB
D018528:ATP-Binding Cassette Transporters / Q000737:chemistry / Q000235:genetics*; D017398:Alternative Splicing; D000595:Amino Acid Sequence; D001483:Base Sequence; D001665:Binding Sites; D018432:Drug Resistance, Multiple; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008969:Molecular Sequence Data; D027425:ATP-Binding Cassette, Sub-Family C Proteins
D018528:ATP-Binding Cassette Transporters; D027425:ATP-Binding Cassette, Sub-Family C Proteins; C114462:multidrug resistance-associated protein 3