Abnormal distribution of hippocampal mossy fibers in rats exposed to X-irradiation in utero.
The effects of prenatal X-irradiation (0.3, 0.6, 1.2 or 1.8 Gy) on the hippocampal development were examined at six weeks of age in rats. The laminar structure of the hippocampus was deranged in the rats exposed to 0.6 Gy or more. Pyramidal cells in the CA-3 region were more susceptible than those in the CA-1 region. Aberrant mossy fiber terminals were observed in the stratum oriens of the CA-3 region (infrapyramidal mossy fibers) in rats exposed to 0.3 Gy or more.
Miki
T
T
Department of Anatomy, Faculty of Medicine, Kagawa Medical University, 1750-1 Ikenobe, Miki-cho, Kagawa 761-07, Japan.
Sawada
K
K
Sun
X Z
XZ
Hisano
S
S
Takeuchi
Y
Y
Fukui
Y
Y
D000818:Animals; D000831:Animals, Newborn / Q000033:anatomy & histology; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005333:Fetus / Q000528:radiation effects; D008297:Male; D019599:Mossy Fibers, Hippocampal / Q000528:radiation effects* / Q000648:ultrastructure*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats / Q000196:embryology; D012016:Reference Values; D014916:Whole-Body Irradiation