title: [Reduction of obesity and improvement in metabolic parameters by inhibition of intestinal lipases: current results with orlistat].
abstract: Until recently, obesity did not play a major role in considerations of physicians and public health authorities. The impact of health-threatening overweight was so far considered only as a risk factor for various other serious illnesses, such as hypertension, diabetes mellitus, hyperuricemia, elevated blood lipid levels and of vascular diseases of the heart, the brain and the kidneys. Recently however, obesity has been rated by the WHO as an unique disease, resulting in elevated morbidity and mortality. It is of constantly increasing importance because of the raising number of obese individuals in all industrial countries. In Austria an incidence of 8.5% of the adult population is estimated to be obese with a BMI > 30. Though the established concept for treatment of overweight consists of reduction of the caloric intake by diet, there is an obvious need for drugs making dieting easier acceptable to obese patients for prolonged periods. Orlistat is the first representative of a new class of such drugs, inhibiting intestinal acting lipase thus reducing the intestinal absorption of triglycerides; it contributes, therefore, to a reduced calorie intake. Preliminary results of treatment studies with Orlistat are presented, demonstrating its efficacy in inducing weight loss and improving metabolic parameters with tolerable intestinal side effects. After finalization of international studies, demonstrating efficacy and tolerability, orlistat has been registered in Austria in September 1998.
authors.affiliation: Ambulanz für Diabetes und Stoffwechsel, Medizinischen Universitätsklinik Graz. hermann.toplak@kfunigraz.ac.at
authors.forename: H
authors.initials: H
authors.lastname: Toplak
authors.forename: K
authors.initials: K
authors.lastname: Marhardt
mesh_terms: D000328:Adult; D000368:Aged; D001317:Austria; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004791:Enzyme Inhibitors / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007783:Lactones / Q000008:administration & dosage* / Q000009:adverse effects; D008049:Lipase / Q000037:antagonists & inhibitors*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000188:drug therapy*; D000077403:Orlistat; D016896:Treatment Outcome; D015431:Weight Loss / Q000187:drug effects
chemical_list: D004791:Enzyme Inhibitors; D007783:Lactones; D000077403:Orlistat; D008049:Lipase