Erythrocyte as a potential model for study of lifelong somatic mutations.
The detection and measurement of somatic cell mutation in vivo is an important subject of research for the assessment of human cancer risk induced by various environmental genotoxic factors. The possible mechanisms which influence the persistence of mutant cells of the hematoimmune system in the peripheral blood are presented. The erythroid system is a system which accumulates mutational lesions and so stably generates red blood cells with various phenotypic changes.
Gerashchenko
B I
BI
Institute of Experimental Radiology, Center for Radiation Medicine, Kiev, Ukraine.
D004787:Environmental Pollution; D004912:Erythrocytes; D006801:Humans; D008957:Models, Genetic; D009154:Mutation; D009369:Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics*; D012307:Risk Factors