Inhibition effect of dietary inulin and oligofructose on the growth of transplantable mouse tumor.
BACKGROUND
The influence of 15% inulin or oligofructose incorporated in to the basal diet on the growth of transplantable mouse tumor (TLT) was investigated.


METHODS
This dietary treatment was performed starting at day 7 before tumor transplantation and continued until the end of observation. The results were evaluated by the mortality rates in the ascitic form of tumor, or by twice weekly solid tumor measurements, with vernier caliper. Mortality rates in ascitic tumors and mean solid tumor surface in these experimental groups was compared with those of animals from control groups fed basal diet without supplementary beta (2-1) fructans.


RESULTS
The growth of both forms of transplantable mouse tumors was significantly inhibited by the supplementation of the diet with inulin or oligofructose.


CONCLUSIONS
Such a nontoxic dietary treatment appears to be easily used ad without any risk for patients, and is applicable as an adjuvant factor to classical protocols of human cancer therapy.
Taper
H S
HS
Unité de Biochimie Toxicologique et Cancérologique Université Catholique de Louvain UCL-BCTC 7369, Brussels, Belgium.
Lemort
C
C
Roberfroid
M B
MB
D000704:Analysis of Variance; D000818:Animals; D016588:Anticarcinogenic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002455:Cell Division / Q000187:drug effects; D018890:Chemoprevention; D004040:Dietary Carbohydrates / Q000008:administration & dosage / Q000627:therapeutic use; D019587:Dietary Supplements; D005630:Fructans / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use*; D008113:Liver Neoplasms / Q000401:mortality / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D015996:Survival Rate
D016588:Anticarcinogenic Agents; D004040:Dietary Carbohydrates; D005630:Fructans; D007328:Insulin