title: [Multi-systemic toxicity of colchicine and renal failure: apropos of a case].
abstract: The use of colchicine can produce various side effects, but multiorgan toxicity is rare. We report the first Swiss case of multiorgan toxicity involving typical neuromuscular lesions. Muscular biopsy is a valuable tool in confirming the diagnosis. Renal insufficiency and hepatobiliary diseases are predisposing factors for such complications. Colchicine pharmacology in the case of renal insufficiency is discussed.
authors.affiliation: Clinique de médecine interne, Hôpital cantonal, Fribourg.
authors.forename: L
authors.initials: L
authors.lastname: Rosset
authors.forename: E
authors.initials: E
authors.lastname: Descombes
authors.forename: G
authors.initials: G
authors.lastname: Fellay
authors.forename: C
authors.initials: C
authors.lastname: Regamey
mesh_terms: D000368:Aged; D003078:Colchicine / Q000008:administration & dosage / Q000009:adverse effects*; D006073:Gout / Q000188:drug therapy* / Q000473:pathology; D006074:Gout Suppressants / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000473:pathology; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects / Q000473:pathology; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000473:pathology
chemical_list: D006074:Gout Suppressants; D003078:Colchicine