title: Stimulus sensitivity and neuromodulatory properties of noisy intrinsic neuronal oscillators.
abstract: Intrinsic subthreshold oscillations in the membrane potential are a common property of many neurons in the peripheral and central nervous system. When such oscillations are combined with noise, interesting signal encoding and neuromodulatory properties are obtained which allow, for example, sensitivity adjustment or differential encoding of stimuli. Here we demonstrate that a noisy Hodgkin/Huxley-model for subthreshold oscillations, when tuned to maximum sensitivity, can be significantly modulated by even minor physiological changes in the oscillation parameters amplitude or frequency. Given the ubiquity of subthreshold oscillating neurons, it can be assumed that these findings reflect principle encoding properties which are relevant for an understanding of sensitivity and neuromodulation in peripheral and central neurons.
authors.affiliation: Zentrum für Nervenheilkunde, Klinik für Psychiatrie, Universität Marburg, Germany.
authors.forename: M T
authors.initials: MT
authors.lastname: Huber
authors.forename: J C
authors.initials: JC
authors.lastname: Krieg
authors.forename: M
authors.initials: M
authors.lastname: Dewald
authors.forename: K
authors.initials: K
authors.lastname: Voigt
authors.forename: H A
authors.initials: HA
authors.lastname: Braun
mesh_terms: D000200:Action Potentials; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D013696:Temperature