title: Cerebral perfusion and psychometric testing after exposure to high altitude in the mountains.
abstract: Exposure to hypobaric hypoxia is known to cause reductions in mental performance and decision-making and it has been reported that these effects are not fully reversed following descent from altitude. Eight climbers had cerebral perfusion scans performed and undertook a battery of psychometric tests prior to, and upon return from, an expedition to climb the eleventh highest mountain in the world, Gasherbrum 1. No decrements were found in either their performance on the psychometric tests nor to their cerebral perfusion following the expedition. Two subjects had significant cerebral perfusion abnormalities prior to the expedition, which had improved immediately following their return from the expedition. Repeat scans four months later showed the lesion of one of the subjects had returned and there were indications that the lesion in the other subject was beginning to return. These findings are in contrast to previous studies which have suggested that altitude exposure leads to permanent reductions in brain function, this could be because in those studies factors other than hypobaric hypoxia per se lead to the reductions in brain function.
authors.forename: C M
authors.initials: CM
authors.lastname: Windle
authors.forename: G M
authors.initials: GM
authors.lastname: Slaven
authors.forename: M A
authors.initials: MA
authors.lastname: Macleod
mesh_terms: D000328:Adult; D000531:Altitude; D002560:Cerebrovascular Circulation; D006801:Humans; D008297:Male; D008606:Mental Processes; D008875:Middle Aged; D008889:Military Personnel; D009051:Mountaineering / Q000502:physiology*; D011594:Psychometrics