The effect of mitomycin-C on the biodistribution of 99Tcm-MDP in Balb/c mice.
Drug therapy can alter the biodistribution of radiopharmaceuticals. We studied the effect of mitomycin-C, a drug used in oncology, on the biodistribution in mice of 99Tcm-methylene diphosphonic acid (99Tcm-MDP). Three doses of mitomycin-C were administered. After the last dose, 99Tcm-MDP was injected and the animals were killed. The organs were isolated, their weight determined and the percent per gram injected dose (%ID/g) calculated. The %ID/g had increased in the pancreas, ovary, stomach, uterus, kidneys, spleen, thymus, heart, liver and lungs, but did not change significantly in thyroid, bone or brain. As a change in 99Tcm-MDP uptake by bone is not observed, a modification to bone scintigraphy is not required. As mitomycin-C treatment altered 99Tcm-MDP uptake in some organs, any hot spots should be evaluated carefully to avoid a misdiagnosis.
Gomes
M L
ML
Instituto Nacional do Câncer, Centro de Pesquisa Básica, Praça Cruz, Rio de Janeiro, Brasil.
de Souza Braga
A C
AC
de Mattos
D M
DM
de Souza Freitas
R
R
Boasquevisque
E M
EM
Bernardo-Filho
M
M
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D016685:Mitomycin / Q000494:pharmacology*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D013669:Technetium Tc 99m Medronate / Q000493:pharmacokinetics*; D014018:Tissue Distribution / Q000187:drug effects
D019275:Radiopharmaceuticals; D016685:Mitomycin; D013669:Technetium Tc 99m Medronate