title: [Wound botulism in heroin addiction].
abstract: Botulism is a rare disease which usually is caused by preformed botulinum toxin in food. However, this article describes a case of wound botulism in a 29-year-old male heroin addict who developed progressive diplopia, dysphagia and proximal weakness of skeletal limb muscles. He needed mechanical ventilation for two weeks. The clinical diagnosis of botulism was supported by neurophysiological tests. Assays for detection of botulinum toxin and Clostridium botulinum were negative. The patient had not eaten any contaminated food the last two weeks before symptoms appeared, but he had multiple contaminated skin wounds. After treatment with botulinum antitoxins and antibiotics he gradually recovered, and six weeks later he was discharged from hospital in good condition. To the best of our knowledge this is the first case of wound botulism reported in Norway.
authors.affiliation: Anestesi/intensivavdelingen, Haukeland Sykehus, Bergen.
authors.forename: G
authors.initials: G
authors.lastname: Holmaas
authors.forename: N E
authors.initials: NE
authors.lastname: Gilhus
authors.forename: I O
authors.initials: IO
authors.lastname: Gjerde
authors.forename: S
authors.initials: S
authors.lastname: Lund-Tønnessen
authors.forename: J
authors.initials: J
authors.lastname: Langørgen
mesh_terms: D000328:Adult; D001906:Botulism / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D006556:Heroin Dependence / Q000150:complications* / Q000382:microbiology; D006801:Humans; D008297:Male; D015819:Substance Abuse, Intravenous / Q000150:complications* / Q000382:microbiology; D014946:Wound Infection / Q000382:microbiology*