Determination of drug-metabolizing enzyme activity in vivo: pharmacokinetic and statistical issues.
Tucker
G T
GT
University of Sheffield, Division of Clinical Sciences, Royal Hallamshire Hospital, UK.
Rostami-Hodjegan
A
A
Jackson
P R
PR
D019540:Area Under Curve; D002110:Caffeine / Q000378:metabolism / Q000493:pharmacokinetics; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics* / Q000378:metabolism*; D014644:Genetic Variation; D005828:Genetics, Population; D006801:Humans; D008658:Inactivation, Metabolic; D008954:Models, Biological; D015233:Models, Statistical; D010599:Pharmacokinetics; D011110:Polymorphism, Genetic; D015203:Reproducibility of Results
D002110:Caffeine; D003577:Cytochrome P-450 Enzyme System