Analytic calculation of physiological acid-base parameters in plasma.
Analytic expressions for plasma total titratable base, base excess (DeltaCB), strong-ion difference, change in strong-ion difference (DeltaSID), change in Van Slyke standard bicarbonate (DeltaVSSB), anion gap, and change in anion gap are derived as a function of pH, total buffer ion concentration, and conditional molar equilibrium constants. The behavior of these various parameters under respiratory and metabolic acid-base disturbances for constant and variable buffer ion concentrations is considered. For constant noncarbonate buffer concentrations, DeltaSID = DeltaCB = DeltaVSSB, whereas these equalities no longer hold under changes in noncarbonate buffer concentration. The equivalence is restored if the reference state is changed to include the new buffer concentrations.
Wooten
E W
EW
Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.
D000136:Acid-Base Equilibrium / Q000502:physiology*; D000143:Acids / Q000097:blood; D000465:Algorithms; D000468:Alkalies / Q000097:blood; D001639:Bicarbonates / Q000737:chemistry; D002021:Buffers; D006863:Hydrogen-Ion Concentration; D008962:Models, Theoretical; D010949:Plasma / Q000737:chemistry*
D000143:Acids; D000468:Alkalies; D001639:Bicarbonates; D002021:Buffers