title: Vitamin A functions in the regulation of the dopaminergic system in the brain and pituitary gland.
abstract: Retinoic acids, bound to their receptors, function in the brain and pituitary gland by regulating the expression of the dopamine receptor D2R, which is a component of the dopaminergic system. The liganded retinoic acid receptors are specific transcription factors that are essential for full expression of D2R. D2R-knockout mice lack these retinoic acid receptors and exhibit a defect in locomotor ability similar to that seen in Parkinson's disease.
authors.affiliation: Department of Nutritional Sciences, University of California, Berkeley 94720-3104, USA.
authors.forename: G
authors.initials: G
authors.lastname: Wolf
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D010902:Pituitary Gland / Q000378:metabolism*; D017448:Receptors, Dopamine D2 / Q000235:genetics* / Q000502:physiology; D018168:Receptors, Retinoic Acid / Q000502:physiology; D014801:Vitamin A / Q000502:physiology*
chemical_list: D017448:Receptors, Dopamine D2; D018168:Receptors, Retinoic Acid; D014801:Vitamin A