The value of biochemical and ultrasound measurements in predicting pregnancy outcome in women with a history of recurrent miscarriage.
In this study, the potential prognostic value of serial ultrasonographic, endocrinological and biochemical measurements in the early pregnancy of women with a history of unexplained recurrent miscarriage was examined. A total of 113 pregnancies among 93 women were studied, of which 77 (68%) resulted in live birth, whereas 36 (32%) ended in a miscarriage. The normal range (5-95th centile) of various measurements was derived from pregnancies which resulted in a live birth. Among the 36 failed pregnancies, 42% had one or more human chorionic gonadotrophin (HCG) measurements, 35% had one or more gestation-sac diameter measurements, 33% had one or more embryonic heart rate measurements, 20% had one or more crown-rump length measurements and 9% had one or more placental protein 14 measurements below the normal range, a week or more prior to the confirmation of miscarriage. Altogether, 22/36 = 61% of the failed pregnancies could have been predicted on the basis of one or more of the measurements below the normal range.
Li
T C
TC
Biomedical Research Unit, Jessop Hospital for Women, Sheffield, UK.
Spring
P G
PG
Bygrave
C
C
Laird
S M
SM
Serle
E
E
Spuijbroek
M
M
Adekanmi
O
O
D000026:Abortion, Habitual / Q000175:diagnosis*; D000328:Adult; D006063:Chorionic Gonadotropin / Q000032:analysis; D005260:Female; D000071816:Glycodelin; D006023:Glycoproteins / Q000032:analysis; D006801:Humans; D008875:Middle Aged; D011237:Predictive Value of Tests; D011247:Pregnancy / Q000502:physiology; D011256:Pregnancy Outcome; D011257:Pregnancy Proteins / Q000032:analysis; D014463:Ultrasonography; D014599:Uterus / Q000000981:diagnostic imaging* / Q000378:metabolism*
D006063:Chorionic Gonadotropin; D000071816:Glycodelin; D006023:Glycoproteins; C045246:PAEP protein, human; D011257:Pregnancy Proteins