title: Implication of ZOG protein (zona glomerulosa-specific protein) in zone development of the adrenal cortex.
abstract: The three zones of adrenal cortex are thought to arise from a single multipotential stem cell. Immunohistochemical studies of fetal and adult adrenals using an antibody against a previously-cloned ZOG protein, a rat homolog of Pref-1, were conducted to explore its roles in the differentiation of cortical tissues. At the early embryonic stage, ZOG was already expressed in adrenogonadal primordial cells. The ZOG-positive cells gradually formed the adrenal primordium by E14.5. By E17.5 the expression was repressed in the inner part of the aggregate and these cells began to express CYP11B1. The ZOG-positive cells at this stage existed at the periphery of the aggregate but they did not express CYP11B2 yet. Not until E20.5 did the aldosteronogenic cells appear among the ZOG-positive cells at the outermost part of the gland. Based on these and the other findings the zonal development of the adrenal cortex is discussed.
authors.affiliation: Department of Molecular Physiological Chemistry, Osaka University Medical School, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Okamoto
authors.forename: H
authors.initials: H
authors.lastname: Takemori
authors.forename: S K
authors.initials: SK
authors.lastname: Halder
authors.forename: Y
authors.initials: Y
authors.lastname: Nonaka
authors.forename: O
authors.initials: O
authors.lastname: Hatano
mesh_terms: D000302:Adrenal Cortex / Q000196:embryology* / Q000378:metabolism; D000375:Aging / Q000378:metabolism; D000450:Aldosterone / Q000378:metabolism; D000818:Animals; D000941:Antigens / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D005314:Embryonic and Fetal Development / Q000502:physiology; D005333:Fetus / Q000378:metabolism; D051717:Fushi Tarazu Transcription Factors; D018398:Homeodomain Proteins; D007150:Immunohistochemistry; D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D018160:Receptors, Cytoplasmic and Nuclear; D013252:Steroid 11-beta-Hydroxylase / Q000378:metabolism; D054339:Steroidogenic Factor 1; D014157:Transcription Factors / Q000378:metabolism; D015385:Zona Reticularis / Q000276:immunology
chemical_list: D000941:Antigens; D004268:DNA-Binding Proteins; C512923:Dlk1 protein, rat; D051717:Fushi Tarazu Transcription Factors; D018398:Homeodomain Proteins; D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D054339:Steroidogenic Factor 1; D014157:Transcription Factors; D000450:Aldosterone; D013252:Steroid 11-beta-Hydroxylase