title: Salivary defence factor concentrations in relation to oral and general parameters in HIV positive patients.
abstract: The objective of this study was to determine the relationships between saliva protein concentrations, oral mucosal lesions, and systemic parameters in HIV positive patients and controls. Twenty-three control volunteers and 58 HIV-antibody positive patients received a complete oral examination and medical evaluation. In saliva and serum samples, protein concentrations were recorded by a nephelometric method. The systemic parameters assessed were CD4+ cell count, CDC stages and antiretroviral therapy. Oral mucosal lesion prevalence was higher among subjects with lower CD4+ counts. Considering the protein profile, correlations were recorded between saliva and serum protein concentration for IgA, haptoglobin and alpha1-proteinase inhibitor. Using assays of immune and non-immune saliva defence factors, we found that the evolution of cellular immuno-suppression during HIV infection was correlated to oral mucosal disease, showing a relationship between local and general systems.
authors.affiliation: Laboratory for Oro-Facial Biology, Faculty of Dentistry, Toulouse III University and Hôtel Dieu, University Hospital, France. doydenta@adm.ups-tlse.fr
authors.forename: A M
authors.initials: AM
authors.lastname: Grimoud
authors.forename: C
authors.initials: C
authors.lastname: Arnaud
authors.forename: P
authors.initials: P
authors.lastname: Dellamonica
authors.forename: J P
authors.initials: JP
authors.lastname: Lodter
mesh_terms: D000328:Adult; D000418:Albumins / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis; D018791:CD4 Lymphocyte Count; D002180:Candidiasis, Oral / Q000097:blood / Q000150:complications / Q000276:immunology; D016022:Case-Control Studies; D003176:Complement C3 / Q000032:analysis; D005260:Female; D006679:HIV Seropositivity / Q000097:blood / Q000150:complications / Q000276:immunology*; D006242:Haptoglobins / Q000032:analysis; D006801:Humans; D007111:Immunity, Cellular; D018928:Immunity, Mucosal; D007132:Immunoglobulin Isotypes / Q000032:analysis / Q000097:blood; D017733:Leukoplakia, Hairy / Q000097:blood / Q000150:complications / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology; D009391:Nephelometry and Turbidimetry; D009961:Orosomucoid / Q000032:analysis; D010518:Periodontitis / Q000097:blood / Q000150:complications / Q000276:immunology; D012471:Salivary Proteins and Peptides / Q000032:analysis* / Q000276:immunology*; D018709:Statistics, Nonparametric; D014168:Transferrin / Q000032:analysis; D000515:alpha 1-Antitrypsin / Q000032:analysis; D000511:alpha-Macroglobulins / Q000032:analysis
chemical_list: D000418:Albumins; D001798:Blood Proteins; D003176:Complement C3; D006242:Haptoglobins; D007132:Immunoglobulin Isotypes; D009961:Orosomucoid; D012471:Salivary Proteins and Peptides; D014168:Transferrin; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins