title: [Hepatic mesenchymal hamartoma in children. Immunohistochemical, ultrastructural and flow cytometric case study].
abstract: Mesenchymal hamartoma is a rare liver lesion. This lesion was found in a 7-month-old girl with high serum alphafaetoprotein serum levels and was composed of loose connective tissue containing a certain number of epithelial cells of biliary or hepatic origin. Immunohistochemical studies showed that cytokeratins 7 and 19 were localized in bile duct epithelium. The ultrastructural study showed that the hamartoma was composed of well differentiated ductal structures surrounded by a myxoid mesenchyma with cysts formed either from degenerative mesenchymal areas or from dilated ducts. Flow cytometric analysis of nuclei from frozen tissue revealed that the lesion was DNA aneuploid, with a DNA index of 1.28.
authors.affiliation: Laboratoire d'Anatomie Pathologique, Faculté de Médecine, Dijon.
authors.forename: E
authors.initials: E
authors.lastname: Justrabo
authors.forename: L
authors.initials: L
authors.lastname: Martin
authors.forename: N
authors.initials: N
authors.lastname: Yaziji
authors.forename: J P
authors.initials: JP
authors.lastname: Couillault
authors.forename: E
authors.initials: E
authors.lastname: Gounot
authors.forename: N O
authors.initials: NO
authors.lastname: Olsson
authors.forename: F
authors.initials: F
authors.lastname: Piard
mesh_terms: D000782:Aneuploidy; D004247:DNA / Q000032:analysis; D005260:Female; D005434:Flow Cytometry; D006222:Hamartoma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D053552:Keratin-7; D007633:Keratins / Q000032:analysis; D008107:Liver Diseases / Q000378:metabolism / Q000473:pathology*; D008940:Mitotic Index; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: C507497:KRT7 protein, human; D053552:Keratin-7; D000509:alpha-Fetoproteins; D007633:Keratins; D004247:DNA