title: Effects of hemodialyzer reuse on clearances of urea and beta2-microglobulin. The Hemodialysis (HEMO) Study Group.
abstract: Although dialyzer reuse in chronic hemodialysis patients is commonly practiced in the United States, performance of reused dialyzers has not been extensively and critically evaluated. The present study analyzes data extracted from a multicenter clinical trial (the HEMO Study) and examines the effect of reuse on urea and beta2-microglobulin (beta2M) clearance by low-flux and high-flux dialyzers reprocessed with various germicides. The dialyzers evaluated contained either modified cellulosic or polysulfone membranes, whereas the germicides examined included peroxyacetic acid/acetic acid/hydrogen peroxide combination (Renalin), bleach in conjunction with formaldehyde, glutaraldehyde or Renalin, and heated citric acid. Clearance of beta2M decreased, remained unchanged, or increased substantially with reuse, depending on both the membrane material and the reprocessing technique. In contrast, urea clearance decreased only slightly (approximately 1 to 2% per 10 reuses), albeit statistically significantly with reuse, regardless of the porosity of the membrane and reprocessing method. Inasmuch as patient survival in the chronic hemodialysis population is influenced by clearances of small solutes and middle molecules, precise knowledge of the membrane material and reprocessing technique is important for the prescription of hemodialysis in centers practicing reuse.
authors.affiliation: University of Utah, Salt Lake City, USA.
authors.forename: A K
authors.initials: AK
authors.lastname: Cheung
authors.forename: L Y
authors.initials: LY
authors.lastname: Agodoa
authors.forename: J T
authors.initials: JT
authors.lastname: Daugirdas
authors.forename: T A
authors.initials: TA
authors.lastname: Depner
authors.forename: F A
authors.initials: FA
authors.lastname: Gotch
authors.forename: T
authors.initials: T
authors.lastname: Greene
authors.forename: N W
authors.initials: NW
authors.lastname: Levin
authors.forename: J K
authors.initials: JK
authors.lastname: Leypoldt
mesh_terms: D019342:Acetic Acid; D019343:Citric Acid; D004202:Disinfectants; D004338:Drug Combinations; D006801:Humans; D006861:Hydrogen Peroxide; D008567:Membranes, Artificial; D010463:Peracetic Acid; D011446:Prospective Studies; D006435:Renal Dialysis / Q000295:instrumentation* / Q000379:methods / Q000592:standards*; D014508:Urea / Q000097:blood*; D001613:beta 2-Microglobulin / Q000032:analysis*
chemical_list: D004202:Disinfectants; D004338:Drug Combinations; D008567:Membranes, Artificial; C117603:Renalin; D001613:beta 2-Microglobulin; D019343:Citric Acid; D014508:Urea; D006861:Hydrogen Peroxide; D010463:Peracetic Acid; D019342:Acetic Acid