title: Sensitivity to CCK-4 in women with and without premenstrual dysphoric disorder (PMDD) during their follicular and luteal phases.
abstract: The authors determined whether women with premenstrual dysphoric disorder (PMDD) exhibit a heightened sensitivity to the panicogenic effects of CCK-4 administration and whether this enhanced sensitivity to CCK-4 would vary with the phase of the menstrual cycle at the time of CCK-4 injection. Twenty-one normal controls and 18 PMDD women were randomly assigned to receive the first and second CCK-4 injection during the follicular phase and the luteal phase or vice versa. PMDD women showed a greater anxiety and panic response to CCK-4. These preliminary results suggest that the CCK-B system may play a role in the pathophysiology of PMDD.
authors.affiliation: Clarke Institute of Psychiatry, University of Montreal, Quebec, Canada.
authors.forename: J M
authors.initials: JM
authors.lastname: Le Mellédo
authors.forename: S
authors.initials: S
authors.lastname: Merani
authors.forename: D
authors.initials: D
authors.lastname: Koszycki
authors.forename: F
authors.initials: F
authors.lastname: Bellavance
authors.forename: R
authors.initials: R
authors.lastname: Palmour
authors.forename: J
authors.initials: J
authors.lastname: Gutkowska
authors.forename: S
authors.initials: S
authors.lastname: Steinberg
authors.forename: D G
authors.initials: DG
authors.lastname: Bichet
authors.forename: J
authors.initials: J
authors.lastname: Bradwejn
mesh_terms: D000328:Adult; D001007:Anxiety / Q000139:chemically induced; D018592:Cross-Over Studies; D005260:Female; D005498:Follicular Phase; D006728:Hormones / Q000378:metabolism; D006801:Humans; D008183:Luteal Phase; D010200:Panic; D011293:Premenstrual Syndrome / Q000503:physiopathology*; D013758:Tetragastrin / Q000009:adverse effects / Q000494:pharmacology*
chemical_list: D006728:Hormones; D013758:Tetragastrin