title: [Food and food additives hypersensitivity in adult asthmatics. III. Adverse reaction to sulfites in adult asthmatics].
abstract: OBJECTIVE
  Many studies show that sulfites cause multiple atopic manifestations by oral challenge in USA and Europe, however, there are few reports of sulfites sensitivity in Japan. The aim of this study establishes the presence of sulfites hypersensitivities in asthmatic subjects in Japan.
  
  
  METHODS
  Twenty adult asthmatic patients, who were non-steroid-dependent and without a suggestive history of sulfite sensitivity, underwent challenge with oral solution of metabisulfite.
  
  
  RESULTS
  Of 12 patients reacted to metabisulfite. They demonstrated airway obstruction 5 (41.7%), urticaria 4 (36.7%), skin manifestation 2 (16.7%) and nasal congestion 1 (8.3%). All patients who demonstrated airway obstruction, were sensitive to aspirin.
  
  
  CONCLUSIONS
  Oral sulfite challenge should be made in patients with urticaria, that are not able to find out causative antigen, even though no suggestive history of sulfite sensitivity.
authors.affiliation: Department of Allergy and Respiratory Medicine, Doai Memorial Hospital.
authors.forename: Y
authors.initials: Y
authors.lastname: Arai
authors.forename: H
authors.initials: H
authors.lastname: Muto
authors.forename: Y
authors.initials: Y
authors.lastname: Sano
authors.forename: K
authors.initials: K
authors.lastname: Ito
mesh_terms: D000328:Adult; D001249:Asthma / Q000276:immunology*; D005260:Female; D005512:Food Hypersensitivity / Q000175:diagnosis* / Q000209:etiology; D005520:Food Preservatives / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013447:Sulfites / Q000009:adverse effects*; D014581:Urticaria / Q000276:immunology
chemical_list: D005520:Food Preservatives; D013447:Sulfites