title: [Multiple angiodysplastic lesions of the colon--a therapeutic challenge].
abstract: Colonic angiodysplasia is one of the most frequent causes of recurrent lower gastrointestinal tract bleeding, mainly in the elderly. In 50% of patients multiple angiodysplastic lesions were reported when they were the cause of rectal bleeding. Bleeding from angiodysplasia is more severe and less responsive to treatment in those with coagulation disorders. A 74-year-old woman with an artificial mitral valve who was treated with coumadine is reported. A few years after operation she began to develop severe recurrent rectal bleeding because of multiple angiodysplastic lesions along the right colon, proven by colonoscopy. She was frequently hospitalized for blood transfusions; endoscopic treatment was not feasible and the surgical risk of colectomy was very high. Treatment with estrogen and progesterone significantly decreased recurrent episodes of bleeding.
authors.affiliation: Division of Gastroenterology, E, Soroka Medical Center, Beer Sheba.
authors.forename: N
authors.initials: N
authors.lastname: Hilzenrat
authors.forename: E
authors.initials: E
authors.lastname: Liberty
mesh_terms: D000368:Aged; D016888:Angiodysplasia / Q000209:etiology / Q000628:therapy*; D000925:Anticoagulants / Q000009:adverse effects; D001803:Blood Transfusion; D003108:Colonic Diseases / Q000209:etiology / Q000628:therapy*; D004997:Ethinyl Estradiol / Q000627:therapeutic use; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D006350:Heart Valve Prosthesis; D006801:Humans; D009644:Norgestrel / Q000627:therapeutic use; D014859:Warfarin / Q000009:adverse effects
chemical_list: D000925:Anticoagulants; D009644:Norgestrel; D004997:Ethinyl Estradiol; D014859:Warfarin