title: [Repeated hypergravity: morphologic investigations of pituitary, thyroid, blood and bone marrow in rats].
abstract: To elicit the mechanism of facilitating the mammals' adaptation to repeated changed gravity influence, the pituitary, thyroid, blood and bone marrow were investigated morphologically in rats exposed to single and repeated hypergravity (2 g) and Coriolis accelerations for 5 days during rotation on centrifuge. No distinct difference in blood and bone marrow cytology was determined after single and repeated exposure to 2 g and the Coriolis accelerations. Compared to single and in contrast to single and repeated exposures to the Coriolis accelerations, a repeated 2 g influence produced some structural changes in somatotropic cells of the pituitary and thyroid parenchyma of the thyroid. These changes were indicative of a significant intensification of synthesis and secretion of somatotropic and thyroid hormones. Elevated functional activity of the somatotropic cells and thyroid parenchyma during repeated exposure to 2 g appears to be a part of mechanism that makes adaptation to repeated hypergravity easier and points to the ability of mammals "to remember" changed gravity. It also advocates for the potentiality of intermittent centrifugation as a means of generating artificial gravity forces in space flight.
authors.forename: I B
authors.initials: IB
authors.lastname: Krasnov
authors.forename: E I
authors.initials: EI
authors.lastname: Alekseev
authors.forename: V I
authors.initials: VI
authors.lastname: Loginov
authors.forename: T E
authors.initials: TE
authors.lastname: Burkovskaia
authors.forename: N A
authors.initials: NA
authors.lastname: Chel'naia
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001773:Blood Cells / Q000166:cytology*; D001854:Bone Marrow Cells / Q000166:cytology*; D002498:Centrifugation; D005500:Follow-Up Studies; D013006:Growth Hormone / Q000096:biosynthesis / Q000378:metabolism; D018471:Hypergravity; D008297:Male; D010902:Pituitary Gland / Q000166:cytology* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013961:Thyroid Gland / Q000166:cytology* / Q000378:metabolism; D013963:Thyroid Hormones / Q000096:biosynthesis / Q000378:metabolism
chemical_list: D013963:Thyroid Hormones; D013006:Growth Hormone