[The creation of original Russian beta-adrenoblockers].
Results of search for new beta-adrenoreceptor blocking agents of different effects are summarized. Derivatives of 4-hydroxyindolyl-3-acetic acid are characterized by a prolonged beta-adrenoblocking effect, cardioselective beta-adrenoblockers were found among derivatives of N,N-bis(2-hydroxy-3-phenoxypropanol)amine, and highly effective "hybrid" beta-,a-adrenoblockers were detected among derivatives of 3(5)-phenoxymethylisoxazolines and 5-phenoxymethyl-1,2,4,-oxadiasoles. Clinical studies of one of the most promising compounds of the latter series named proxodolol showed it to be a highly effective antihypertensive, antianginal, and antiglaucoma drug. Proxodolol is permitted for clinical application. At present it is manufactured as eye drops for decreasing intraocular pressure in glaucoma; its production as a solution for injections for arresting hypertensive crises is starting.
Mashkovskiĭ
M D
MD
Iuzhakov
S D
SD
Vinogradova
S M
SM
Sokolov
S D
SD
Suvorov
N N
NN
Vinograd
L Kh
LKh
Shvedov
V I
VI
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D006801:Humans; D012106:Research; D012426:Russia; D013329:Structure-Activity Relationship
D000319:Adrenergic beta-Antagonists