title: Successful treatment of pustulosis palmaris et plantaris with granulocyte colony stimulating factor in a patient with hereditary neutropenia.
abstract: A 26-year-old female with hereditary neutropenia had Pustulosis Palmaris et Plantaris. Drug administration did not improve her symptoms. Following administration of granulocyte colony stimulating factor (G-CSF; filgrastim), her neutrophil count increased from 300 to 58,000/microliters, and her dermatosis improved. Pustulosis Palmaris et Plantaris has been described as a representative second lesion of focal infection. Neutropenia may be one cause of Pustulosis Palmaris et Plantaris due to refractory focal infection. In the present case, increase in neutrophils with G-CSF may have improved focal infection, resulting in improvement in refractory Pustulosis Palmaris et Plantaris.
authors.affiliation: Department of Clinical Hematology, Osaka City University Medical School, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hino
authors.forename: T
authors.initials: T
authors.lastname: Yamane
authors.forename: T
authors.initials: T
authors.lastname: Kuwaki
authors.forename: T
authors.initials: T
authors.lastname: Kono
authors.forename: S
authors.initials: S
authors.lastname: Kitagawa
authors.forename: N
authors.initials: N
authors.lastname: Tatsumi
mesh_terms: D000328:Adult; D005192:Family Health; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D009503:Neutropenia / Q000150:complications* / Q000235:genetics; D011565:Psoriasis / Q000188:drug therapy* / Q000209:etiology*
chemical_list: D016179:Granulocyte Colony-Stimulating Factor