Acute lipase-induced panniculitis in rats with ligated veins of the hindlimb: a contribution to the role of acute panniculitis as a precursor of lipodermatosclerosis of venous disease.
The authors studied the effect of ligation of the femoral and saphenous veins on the evolution of lipase injection-induced subcutaneous fibrosis and inflammation in the rats' hindlimbs. The superficial muscular fascia was thickened and the number of veins was increased 3 days and 3 weeks after vein ligation; both abnormalities disappeared 6 weeks postoperatively. Vein ligation did not quantitatively affect fascial thickening or fibrosing panniculitis in hindlimbs injected with lipase 6 weeks prior to sacrifice. The results contradict the proposition that lipase-induced injury of rats' subcutaneous tissues compromised by venous stasis may lead to a persistent chronic inflammation and fibrosis of the subcutaneous-fascial complex duplicating lipodermatosclerosis in man.
Naschitz
J E
JE
Department of Internal Medicine A, Bnai-Zion Medical Center and The Bruce Rapapport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.
Bejar
J
J
Mogilner
J
J
Misselevich
I
I
Steiner
Z
Z
Eldar
S
S
Yeshurun
D
D
Boss
J H
JH
D000208:Acute Disease; D000273:Adipose Tissue / Q000187:drug effects; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D005268:Femoral Vein / Q000473:pathology / Q000601:surgery; D006614:Hindlimb / Q000098:blood supply / Q000473:pathology; D008026:Ligation; D008049:Lipase / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D015434:Panniculitis / Q000139:chemically induced / Q000473:pathology* / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012501:Saphenous Vein / Q000473:pathology / Q000601:surgery; D012867:Skin / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D014652:Vascular Diseases / Q000503:physiopathology; D014680:Veins / Q000473:pathology / Q000601:surgery*; D014689:Venous Insufficiency / Q000503:physiopathology
D008049:Lipase