A forward model for maximum expiration.
The maximum expiratory flow-volume (MEFV) curve is a sensitive test of respiratory mechanics. Several mathematical models for forced expiration have been developed, but they suffer from various shortcomings. It is impossible to calculate the parts of the MEFV curve beyond the flow limiting conditions and computational algorithms do not allow a direct calculation of maximal flow. In the present work a complex, nonlinear forward model, including exciting signal and static recoil pressure-lung volume descriptions and 132 parameters, has been constructed. Direct determination of maximum flow is achieved by means of successive approximation algorithm. The model enables prediction of flow during forced expiration in the whole range of forced vital capacity.
Polak
A G
AG
Department of Electronics, Wroclaw University of Technology, Poland. polak@kmeif.pwr.wroc.pl
D000465:Algorithms; D003198:Computer Simulation; D005540:Forced Expiratory Flow Rates; D006801:Humans; D008168:Lung / Q000502:physiology*; D008449:Maximal Expiratory Flow-Volume Curves; D008954:Models, Biological; D017711:Nonlinear Dynamics; D015656:Respiratory Mechanics