A novel anti-inflammatory activity of lysozyme: modulation of serum complement activation.
Lysozyme is an ubiquitous enzyme found in most biological secretions and leukocytes. This study was aimed at investigating its interaction with other inflammatory mediators on mucosa surfaces, particularly the complement system. Lysozyme has been shown in our present study, to inhibit the haemolytic activity of serum complement in a dose-dependent fashion, when tested within the levels present in normal and inflamed breast-milk samples, and other mucosal secretions. This represents a new anti-inflammatory action of lysozyme in relation to the serum complement, and the exact mode of the interaction need further studies.
Ogundele
M O
MO
Department of Immunology, Georg-August University, Göttingen, Germany.
D000818:Animals; D003167:Complement Activation / Q000187:drug effects*; D015941:Complement Hemolytic Activity Assay; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D018928:Immunity, Mucosal; D066298:In Vitro Techniques; D007249:Inflammation / Q000201:enzymology / Q000517:prevention & control*; D018836:Inflammation Mediators / Q000378:metabolism; D008895:Milk, Human / Q000201:enzymology; D009113:Muramidase / Q000378:metabolism / Q000494:pharmacology*; D012756:Sheep
D018836:Inflammation Mediators; D009113:Muramidase