(S)-4C3HPG reduces infarct size after focal cerebral ischemia.
This study investigated whether the metabotropic glutamate receptor ligand (S)-4C3HPG can reduce brain damage after focal ischemia in rats. Application of 1 micromol of (S)-4C3HPG (intracerebroventricularly) 5 min after occlusion of the middle cerebral artery significantly reduced the infarct size by 72.3% of the saline control.
Rauca
C
C
Institute of Pharmacology and Toxicology, Medical Faculty of Otto-von-Guericke University Magdeburg, Germany. ipt@uni-magdeburg.de
Henrich-Noack
P
P
Schäfer
K
K
Höllt
V
V
Reymann
K G
KG
D000818:Animals; D002544:Cerebral Infarction / Q000209:etiology / Q000517:prevention & control*; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology; D005998:Glycine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D007276:Injections, Intraventricular; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D018696:Neuroprotective Agents; C078245:4-carboxy-3-hydroxyphenylglycine; D005998:Glycine