Concealed locations of lentiviruses in caprine arthritis encephalitis system.
Ultrastructural examinations of ovine and caprine tissue culture cell lines infected with a molecular sheep lentivirus clone KV72 revealed typical cytoplasmic A type retrovirus particles and budding particles from plasma cell membrane. Blood examinations of a heavily caprine arthritis encephalitis virus-afflicted herd revealed that three goats, which on previous blood examinations had showed a high level of infection, had become negative. Two of these goats underwent a necropsy. The main findings were the presence of typical intracytoplasmic A-type particles found only in neural tissue. No budding or extracellular retrovirus particles were seen in any of the neural tissue examined or in lymph nodes, spleen, or buffy coat cell samples of these animals. This concealed location may be in some analogy with the human immunodeficiency virus system. Despite undetectable blood levels of human immunodeficiency virus in patients after potent combination therapies, they may still harbor latent viruses in different loci.
Perk
K
K
Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot Campus, Israel. Perk@agri.huji.ac.il
D000818:Animals; D016088:Arthritis-Encephalitis Virus, Caprine / Q000302:isolation & purification / Q000502:physiology*; D002460:Cell Line; D015511:Goat Diseases / Q000821:virology*; D006041:Goats; D007557:Israel / Q000453:epidemiology; D016180:Lentivirus Infections / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D012756:Sheep; D012757:Sheep Diseases / Q000821:virology*; D014771:Virion / Q000302:isolation & purification; D017735:Virus Latency