[Drug clinics. How I treat various metabolic diseases treated by a drug intervention that targets the intestine].
Besides the classical dietary regimen, it is possible to use specific pharmacological approaches, targeted at the intestine, in order to treat some metabolic disorders. Three approaches will be described: anionic resins for treating hypercholesterolaemia, alpha-glucosidase inhibitors for treating diabetes mellitus and reactive hypoglycaemia, and intestinal lipase inhibitors for treating obesity. All these drugs are based on original concepts, but their clinical use is often limited by the occurrence of digestive side-effects. The latter may generally be reduced by progressive and individual titration of the dosage of each drug and/or by following an appropriate diet.
Scheen
A J
AJ
Département de Médecine, CHU Sart Tilman, Liège 1.
D020909:Acarbose; D000837:Anion Exchange Resins / Q000009:adverse effects / Q000627:therapeutic use; D019440:Anti-Obesity Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002792:Cholestyramine Resin / Q000009:adverse effects / Q000627:therapeutic use; D003920:Diabetes Mellitus / Q000188:drug therapy; D004791:Enzyme Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D065089:Glycoside Hydrolase Inhibitors; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy; D007003:Hypoglycemia / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D000960:Hypolipidemic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D007421:Intestine, Small / Q000187:drug effects*; D007783:Lactones / Q000009:adverse effects / Q000627:therapeutic use; D008049:Lipase / Q000037:antagonists & inhibitors; D008659:Metabolic Diseases / Q000178:diet therapy / Q000188:drug therapy*; D000077403:Orlistat; D014312:Trisaccharides / Q000009:adverse effects / Q000627:therapeutic use
D000837:Anion Exchange Resins; D019440:Anti-Obesity Agents; D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D007783:Lactones; D014312:Trisaccharides; D002792:Cholestyramine Resin; D000077403:Orlistat; D008049:Lipase; D020909:Acarbose