title: Neutron capture therapy with a new boron-porphyrin compound in the rat 9L glioma model.
abstract: Neutron capture therapy with a new boron-porphyrin compound was tested in a rat brain tumor model. Although the concentration of boron in the tumor was too low to elicit a therapeutic effect, prominent histopathologic changes, such as necrosis, congestion and bleeding were observed in the tumors of the rats which were administered the boron neutron capture therapy.
authors.affiliation: Dept. of Neurosurgery, University of Tsukuba, Toyo Hakka Co. Ltd., Ibaraki, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Shibata
authors.forename: A
authors.initials: A
authors.lastname: Matsumura
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: K
authors.initials: K
authors.lastname: Nakagawa
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshii
authors.forename: T
authors.initials: T
authors.lastname: Nose
authors.forename: I
authors.initials: I
authors.lastname: Sakata
authors.forename: S
authors.initials: S
authors.lastname: Nakajima
authors.forename: Y
authors.initials: Y
authors.lastname: Hayakawa
authors.forename: K
authors.initials: K
authors.lastname: Ono
mesh_terms: D000818:Animals; D016754:Boron Neutron Capture Therapy; D001932:Brain Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D018316:Gliosarcoma / Q000473:pathology / Q000532:radiotherapy*; D008665:Metalloporphyrins / Q000494:pharmacology*; D009336:Necrosis; D011879:Radiotherapy Dosage; D051381:Rats; D011916:Rats, Inbred F344; D016019:Survival Analysis
chemical_list: D008665:Metalloporphyrins; C117848:STA BX900