title: Transplantation of pediatric en bloc cadaver kidneys into adult recipients.
abstract: BACKGROUND
  To maximize the renal donor pool, cadaveric pediatric en bloc kidneys have been transplanted as a dual unit by some transplant centers. We compared the short- and long-term outcomes of adult recipients of cadaveric pediatric en bloc renal transplants versus those of matched recipients of cadaveric adult kidneys.
  
  
  METHODS
  Thirty-three adults who received pediatric en bloc kidney transplants between April 1990 and September 1997 were retrospectively identified and were compared with 33 matched adults who received adult cadaveric kidney transplants. The groups were identical for transplantation era, immunosuppression, recipient sex, race, cause of renal failure, mean weight, and follow-up duration (37.8 vs. 37.5 months). The mean recipient age study versus control was lower (36.3 vs. 48.9 years, P=0.0003). Results. There was no difference between the en bloc and adult donor groups in the 3-year patient survival rates (95% vs. 87%, P=0.16) or the 3-year graft survival rates (87.3% vs. 84.2%, P=0.35). Further, there was no difference in en bloc patient or en bloc graft survival time stratified by recipient age (14-44 vs. >45 years, P=0.11), en bloc donor age (<24 vs. >24 months, P=0.39), or recipient weight (<60, 61-75, >75 kg; P=0.60). Differences in serum creatinine (mg/dl) for the en bloc versus the control group at the time of discharge (3.0 vs. 7.8 mg/dl, P=0.06), at 1 year (1.4 vs. 2.0 mg/dl, P=0.06), and at 2 years (1.1 vs. 1.6 mg/dl, P=0.14) had dissipated by the time of the 5-year follow-up examination (1.1 vs. 1.6 mg/dl, P=0.14). Vascular complications were more prevalent in the en bloc group: renal vein thrombosis (one case), thrombosis of donor aorta (two cases), arterial thrombosis of one renal moiety (two cases), and renal artery stenosis (two cases). There were no differences between groups in delayed graft function, acute or chronic rejection, posttransplant hypertension, posttransplant protein-uria, or long-term graft function.
  
  
  CONCLUSIONS
  Collectively, these data indicate that transplanting pediatric en bloc kidneys into adult recipients results in equivalent patient and graft survival compared with adult cadaveric kidneys. Further, the data also suggest that pediatric en bloc kidneys need not be strictly allocated based on recipient weight or age criteria.
authors.affiliation: Department of Urology, Section of Renal Transplantation, Cleveland Clinic Foundation, Ohio 44195, USA.
authors.forename: M G
authors.initials: MG
authors.lastname: Hobart
authors.forename: C S
authors.initials: CS
authors.lastname: Modlin
authors.forename: A
authors.initials: A
authors.lastname: Kapoor
authors.forename: N
authors.initials: N
authors.lastname: Boparai
authors.forename: B
authors.initials: B
authors.lastname: Mastroianni
authors.forename: D
authors.initials: D
authors.lastname: Papajcik
authors.forename: S M
authors.initials: SM
authors.lastname: Flechner
authors.forename: D A
authors.initials: DA
authors.lastname: Goldfarb
authors.forename: R
authors.initials: R
authors.lastname: Fischer
authors.forename: K J
authors.initials: KJ
authors.lastname: O'Malley
authors.forename: A C
authors.initials: AC
authors.lastname: Novick
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002102:Cadaver; D002675:Child, Preschool; D006085:Graft Survival; D006801:Humans; D007223:Infant; D016030:Kidney Transplantation / Q000009:adverse effects / Q000401:mortality; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate; D013927:Thrombosis / Q000209:etiology