title: Determination of drug-metabolizing enzyme activity in vivo: pharmacokinetic and statistical issues.
authors.affiliation: University of Sheffield, Division of Clinical Sciences, Royal Hallamshire Hospital, UK.
authors.forename: G T
authors.initials: GT
authors.lastname: Tucker
authors.forename: A
authors.initials: A
authors.lastname: Rostami-Hodjegan
authors.forename: P R
authors.initials: PR
authors.lastname: Jackson
mesh_terms: D019540:Area Under Curve; D002110:Caffeine / Q000378:metabolism / Q000493:pharmacokinetics; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics* / Q000378:metabolism*; D014644:Genetic Variation; D005828:Genetics, Population; D006801:Humans; D008658:Inactivation, Metabolic; D008954:Models, Biological; D015233:Models, Statistical; D010599:Pharmacokinetics; D011110:Polymorphism, Genetic; D015203:Reproducibility of Results
chemical_list: D002110:Caffeine; D003577:Cytochrome P-450 Enzyme System