Hemolysin as a virulence factor for systemic infection with isolates of Mycobacterium avium complex.
Isolates of the Mycobacterium avium complex were examined for hemolysin expression. Only invasive isolates of M. avium were observed to be hemolytic (P < 0.001), with activity the greatest for isolates of serovars 4 and 8. Thus, M. avium hemolysin appears to represent a virulence factor necessary for invasive disease.
Maslow
J N
JN
Infectious Diseases Section, Medical Service, VA Medical Center, and Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02130, USA. maslow.joel_n.md@boston.va.gov
Dawson
D
D
Carlin
E A
EA
Holland
S M
SM
D017088:AIDS-Related Opportunistic Infections / Q000382:microbiology; D006460:Hemolysin Proteins / Q000096:biosynthesis*; D006461:Hemolysis; D006801:Humans; D015269:Mycobacterium avium Complex / Q000302:isolation & purification / Q000378:metabolism / Q000472:pathogenicity*; D015270:Mycobacterium avium-intracellulare Infection / Q000382:microbiology*; D014774:Virulence
D006460:Hemolysin Proteins