[The pharmacogenetic concept of the anxio-selective effect].
Hereditary variations in the effects of benzodiazepine tranquilizers depending on the phenotype of an emotional stress reaction (ESR) are described. The membrane-receptor relationship showed differences between C57B1/6 with an "active" ESR phenotype and Balb/c with a "passive" ESR at the GABA benzodiazepine receptor complex level. The pharmacological results evidenced the selective anxiolytic properties of the novel drug aphobazole (2-[2-morpholyno)ethylthio]-5-ethoxybenzimidazole dihydrochloride) which produced an activating anxiolytic action in Balb/c mice whereas no behavioral changes were observed in C57B1/6 mice.
Seredenin
S B
SB
Voronina
T A
TA
Neznamov
G G
GG
Blednov
Iu A
IuA
Badyshtov
B A
BA
Viglinskaia
I V
IV
Kozlovskaia
M M
MM
Kolotilinskaia
N V
NV
Iarkova
M A
MA
Savel'ev
V L
VL
Garibova
T L
TL
Val'dman
E A
EA
D000328:Adult; D000818:Animals; D014151:Anti-Anxiety Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D001569:Benzodiazepines; D003433:Crosses, Genetic; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects; D010597:Pharmacogenetics; D010641:Phenotype; D011600:Psychopharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D018709:Statistics, Nonparametric; D013315:Stress, Psychological / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines