[Immune responses of tuberculosis patients].
Immunity to tuberculosis (TB) required a Th1 pattern of cytokine release. In experimental models even a minor Th2 component abrogates immunity, and leads to an immunopathology that mimics the human disease. There to determine if Th2 cells are present in a peripheral blood, we analyzed the intracellular IL-4 using a flow cytometer. IL-4 producing cells were founded in CD4+ and CD4- Tells. Moreover, we studied about gamma delta (gamma delta) T cells in TB patients. V gamma 9-expressing gamma delta T cells were decreased in patients. However, the proliferative response to PPD by V gamma 9-expressing gamma delta T cells from some patients were higher levels compared with controls. The roles of gamma delta T cells of TB were not yet revealed completely.
Honda
J
J
Oizumi
K
K
D006801:Humans; D018664:Interleukin-12 / Q000096:biosynthesis; D008264:Macrophages / Q000276:immunology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology; D014376:Tuberculosis / Q000276:immunology*
D016692:Receptors, Antigen, T-Cell, gamma-delta; D018664:Interleukin-12