title: Application of chiral chromatographic parameters in quantitative structure-activity relationship analysis of homologous malathion derivatives.
abstract: The conditions of the chiral resolution of the racemic malathion O,O-di-n-alkyl derivatives on cellulose tris(3,5-dimethylphenylcarbamate) are described. Quantitative relationships between chromatographic parameters obtained on chiral and achiral stationary phases and acute toxicity of the compounds towards house fly are derived and discussed.
authors.affiliation: Pharmaceutical Research Institute, Warsaw, Poland.
authors.forename: Z
authors.initials: Z
authors.lastname: Chilmonczyk
authors.forename: H
authors.initials: H
authors.lastname: Ksycińska
authors.forename: I
authors.initials: I
authors.lastname: Poleć
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D007306:Insecticides / Q000737:chemistry*; D008294:Malathion / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D007306:Insecticides; D008294:Malathion