title: Advances in approaches to DNA-based diagnostics.
abstract: The most tangible advances in DNA diagnostics during the past year have been in enhancing existing techniques to simplify their use and improve throughput. This has led to simplified genotyping methods using homogeneous analysis coupled with spectral data output. Miniaturisation and increased throughput have also been achieved through improvements in DNA chip technology.
authors.affiliation: Zeneca Diagnostics Gadbrook Park Northwich Cheshire CW9 7RA UK. david.whitcombe@diagnostics.zeneca.com.
authors.forename: D
authors.initials: D
authors.lastname: Whitcombe
authors.forename: C R
authors.initials: CR
authors.lastname: Newton
authors.forename: S
authors.initials: S
authors.lastname: Little
mesh_terms: D001709:Biotechnology / Q000379:methods; D004247:DNA / Q000235:genetics* / Q000302:isolation & purification; D019937:Diagnostic Techniques and Procedures; D006801:Humans; D009154:Mutation; D016133:Polymerase Chain Reaction / Q000379:methods*
chemical_list: D004247:DNA