title: Epidermal growth factor and its receptor as prognostic indicators in Chinese patients with pancreatic cancer.
abstract: The expression of epidermal growth factor (EGF) and its receptor (EGFR) was studied immunohistochemically in fifty-seven Chinese patients with primary invasive ductal carcinoma (IDC) of the pancreas. The frequency of expression of EGF and EGFR was 73.7% and 68.4%, respectively. The frequency of their co-expression was 61.4%. No significant relationships were seen between the expression of EGF and its receptor and the patients' age, gender, site of the tumor, stage, and grade. Positive co-expression of EGF and EGFR was significantly associated with the poor prognosis. The median survival of the EGF(-)EGFR(-) group for 17.2 months was longer than that of the EGF(+)EGFR(+) group for 9.7 months (p = 0.02), as well as that of the other groups of EGR(+)EGFR(-), EGF(-)EGFR(+), and EGF(+)EGFR(+) for 9.9 month (p = 0.03). These results suggested that EGF and EGFR were frequently expressed in Chinese patients with IDC of the pancreas. Their co-expression may be a useful prognostic indicator for pancreatic cancer.
authors.affiliation: First Department of Surgery, Shimane Medical University, Izumo, Japan. fsurgry@shimane-med.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Dong
authors.forename: Y
authors.initials: Y
authors.lastname: Nio
authors.forename: K J
authors.initials: KJ
authors.lastname: Guo
authors.forename: K
authors.initials: K
authors.lastname: Tamura
authors.forename: Y L
authors.initials: YL
authors.lastname: Tian
authors.forename: Y T
authors.initials: YT
authors.lastname: Dong
mesh_terms: D000328:Adult; D000368:Aged; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D002681:China; D004815:Epidermal Growth Factor / Q000032:analysis*; D066246:ErbB Receptors / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D011379:Prognosis; D016019:Survival Analysis; D013997:Time Factors
chemical_list: D004815:Epidermal Growth Factor; D066246:ErbB Receptors