title: A sesquiterpene lactone glucoside from Ixeris denticulata f. pinnatipartita.
abstract: An extract from the entire Ixeris denticulata f. pinnatipartita plant afforded the guaianolide sesquiterpene lactone glucoside, 8 beta,15-dihydroxy-1(10),3,11(13)-guaiatrien-12,6-olide-15-O- glucopyranoside, along with the known flavonoids luteolin-7-O-glucoside and luteolin-7-O-glucuronide-6'-methyl ester; their structures were determined by spectroscopic methods. Ixerin Y inhibited the growth of human breast cancer MCF7 and MDA468 cell lines.
authors.affiliation: Pharmanex Shanghai R&D Center, Shanghai Medical University, People's Republic China.
authors.forename: J Y
authors.initials: JY
authors.lastname: Ma
authors.forename: Z T
authors.initials: ZT
authors.lastname: Wang
authors.forename: L S
authors.initials: LS
authors.lastname: Xu
authors.forename: G J
authors.initials: GJ
authors.lastname: Xu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D001943:Breast Neoplasms; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification; D018515:Plant Leaves; D010946:Plants, Medicinal; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D005960:Glucosides; D007783:Lactones; D012717:Sesquiterpenes