title: Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle.
abstract: A role for oxidative damage in normal aging is supported by studies in experimental animals, but there is limited evidence in man. We examined markers of oxidative damage to DNA, lipids, and proteins in 66 muscle biopsy specimens from humans aged 25 to 93 years. There were age-dependent increases in 8-hydroxy-2-deoxyguanosine (OH8dG), a marker of oxidative damage to DNA, in malondialdehyde (MDA), a marker of lipid peroxidation, and to a lesser extent in protein carbonyl groups, a marker of protein oxidation. The increases in OH8dG were significantly correlated with increases in MDA. These results provide evidence for a role of oxidative damage in human aging which may contribute to age-dependent losses of muscle strength and stamina.
authors.affiliation: Istituto di Gerontologia e Geriatria, Universitá di Perugia, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Mecocci
authors.forename: G
authors.initials: G
authors.lastname: Fanó
authors.forename: S
authors.initials: S
authors.lastname: Fulle
authors.forename: U
authors.initials: U
authors.lastname: MacGarvey
authors.forename: L
authors.initials: L
authors.lastname: Shinobu
authors.forename: M C
authors.initials: MC
authors.lastname: Polidori
authors.forename: A
authors.initials: A
authors.lastname: Cherubini
authors.forename: J
authors.initials: J
authors.lastname: Vecchiet
authors.forename: U
authors.initials: U
authors.lastname: Senin
authors.forename: M F
authors.initials: MF
authors.lastname: Beal
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D004249:DNA Damage; D005260:Female; D006801:Humans; D016014:Linear Models; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D009124:Muscle Proteins / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology*
chemical_list: D009124:Muscle Proteins