Anti-inflammatory benzopyran-2-ones and their active oxygen species (aos) scavenging activity.
Benzopyrano derivatives were synthesized and evaluated for their anti-inflammatory, ulcerogenic activities and toxicity studies. The in-vitro studies comprised of anti-proteolytic activity, lipid peroxidation inhibitory and reducing activities against alpha, alpha-diphenyl-beta-picrylhydrazyl (DPPH). Two potent compounds were studied further for their inhibition of lipid peroxidation and effect on Superoxide dismutase (SOD) activity in-vivo. These compounds were found promising in all the parameters studied, thereby signifying inter-relationship between their anti-inflammatory activity and anti-oxidant properties.
Bhalla
M
M
Department of Biochemistry, University of Lucknow, India.
Shukla
S
S
Gujrati
V R
VR
Saxena
A K
AK
Sanger
K C
KC
Shanker
K
K
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000494:pharmacology*; D001578:Benzopyrans / Q000138:chemical synthesis / Q000494:pharmacology*; D005260:Female; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001578:Benzopyrans; D016166:Free Radical Scavengers; D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase