Molecular cloning of human GABABR1 and its tissue distribution.
GABABR1 clones were isolated from a human cerebellum library. The human sequence is very similar to rat GABABR1 with the cDNAs sharing 91.3% sequence identity and the receptors sharing 98.6% amino acid sequence identity. Northern blotting has shown that the receptor is brain-specific with a widespread distribution throughout the brain but none detected in the spinal cord.
Makoff
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Departments of Psychological Medicine and Neuroscience, Institute of Psychiatry, Denmark Hill, London, SE7 8AF, UK. a.makoff@iop.bpmf.ac.uk
D017398:Alternative Splicing / Q000502:physiology; D000595:Amino Acid Sequence; D001483:Base Sequence; D015152:Blotting, Northern; D001923:Brain Chemistry / Q000502:physiology*; D003001:Cloning, Molecular; D018076:DNA, Complementary; D006801:Humans; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000032:analysis; D018080:Receptors, GABA-B / Q000235:genetics*; D013116:Spinal Cord / Q000737:chemistry
D018076:DNA, Complementary; D012333:RNA, Messenger; D018080:Receptors, GABA-B