A locus for radiation-induced gastroschisis on mouse Chromosome 7.
Gastroschisis (abdominal wall defects) occurs with a high frequency in the mouse inbred strain HLG compared with C57BL/6J mice. The risk of gastroschisis increases significantly after exposure to irradiation with X-rays during preimplantation development and follows a recessive mode of inheritance for the HLG susceptibility alleles. We have used a backcross strategy and genome-wide microsatellite typing to chromosomally map this trait. A suggestive linkage for a locus responsible for radiation-induced gastroschisis (Rigs1) was found in a region of mouse Chromosome 7.
Hillebrandt
S
S
Institut für Medizinische Strahlenbiologie, Universitätsklinikum Essen, Hufelandstr.55, 45122 Essen, Germany.
Streffer
C
C
Montagutelli
X
X
Balling
R
R
D000009:Abdominal Muscles / Q000002:abnormalities / Q000196:embryology / Q000528:radiation effects; D000016:Abnormalities, Radiation-Induced / Q000235:genetics*; D000818:Animals; D002874:Chromosome Mapping; D002875:Chromosomes / Q000235:genetics*; D003433:Crosses, Genetic; D005260:Female; D005333:Fetus / Q000187:drug effects / Q000378:metabolism; D020139:Gastroschisis / Q000235:genetics*; D005819:Genetic Markers; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D011247:Pregnancy; D014965:X-Rays
D005819:Genetic Markers