title: Analytical techniques used to study the degradation of proteins and peptides: physical instability.
abstract: The physical instability of proteins and peptides as well as the various analytical techniques used to study the various aspects of physical instability have been reviewed. Physical instability of proteins and peptides involve changes in secondary, tertiary and quaternary structures of these compounds. After a general introduction of the subject the literature data of these changes and their analytical aspects have been summarized in a Table.
authors.affiliation: Department of Pharmaceutical Analysis, Faculty of Pharmacy, Utrecht University, The Netherlands.
authors.forename: J L
authors.initials: JL
authors.lastname: Reubsaet
authors.forename: J H
authors.initials: JH
authors.lastname: Beijnen
authors.forename: A
authors.initials: A
authors.lastname: Bult
authors.forename: R J
authors.initials: RJ
authors.lastname: van Maanen
authors.forename: J A
authors.initials: JA
authors.lastname: Marchal
authors.forename: W J
authors.initials: WJ
authors.lastname: Underberg
mesh_terms: D002623:Chemistry Techniques, Analytical / Q000379:methods*; D004355:Drug Stability; D010455:Peptides / Q000378:metabolism*; D011487:Protein Conformation; D011506:Proteins / Q000378:metabolism*
chemical_list: D010455:Peptides; D011506:Proteins