Mutations in XPD helicase prevent its interaction and regulation by p44, another subunit of TFIIH, resulting in Xeroderma pigmentosum (XP) and trichothiodystrophy (TTD) phenotypes.
Coin
F
F
Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Illkirch, France.
Marinoni
J C
JC
Egly
J M
JM
D004265:DNA Helicases / Q000235:genetics*; D004260:DNA Repair; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D009154:Mutation; D051758:Transcription Factor TFIIH; D014157:Transcription Factors / Q000494:pharmacology*; D019473:Transcription Factors, TFII; D014983:Xeroderma Pigmentosum / Q000201:enzymology / Q000235:genetics*
D014157:Transcription Factors; D019473:Transcription Factors, TFII; D051758:Transcription Factor TFIIH; D004265:DNA Helicases