The new antidepressants. Selective serotonin reuptake inhibitors.
This article provides a resource for choosing among available SSRIs to treat pediatric patients. SSRIs are addressed according to five areas of interest: treatment efficacy data, untoward effects profile, pharmacokinetic characteristics, potential drug-drug interactions, and cost. Strategies for SSRI dosing and pretreatment work-up are also discussed. Included in the article is a reference table for SSRI dosing, available preparations, and cost per dose. Also included is an abbreviated reference table of important cytochrome P-450 isoenzymes, isoenzyme inhibition by SSRIs, and selected psychotropic and somatic medication substrates.
Labellarte
M J
MJ
Division of Child and Adolescent Psychiatry, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
Walkup
J T
JT
Riddle
M A
MA
D000293:Adolescent; D001008:Anxiety Disorders / Q000188:drug therapy*; D002648:Child; D003866:Depressive Disorder / Q000188:drug therapy*; D016527:Drug Costs; D004347:Drug Interactions; D006801:Humans; D017367:Selective Serotonin Reuptake Inhibitors / Q000145:classification / Q000191:economics / Q000494:pharmacology / Q000627:therapeutic use*
D017367:Selective Serotonin Reuptake Inhibitors