Changes in urinary taurine and hypotaurine excretion after two-thirds hepatectomy in the rat.
This study followed the time course of urinary taurine and hypotaurine excretion after two-thirds hepatectomy in rats. The excretion of both taurine and hypotaurine was elevated during 18 h following the hepatectomy, with maximal excretion during the first 6 h. Twelve and 24 h after partial hepatectomy, the hepatic hypotaurine concentration was increased but liver taurine did not differ significantly from controls. No changes were observed in hypotaurine and taurine concentrations of heart, kidney, lung, muscle tissue and spleen. We postulate that partial hepatectomy induces a rapid increase of hepatic (hypo)taurine synthesis from precursor amino acids. The increased (hypo)taurine concentrations spill over into urine.
Brand
H S
HS
Department of Oral Biochemistry, ACTA, Amsterdam, The Netherlands. HS.Brand.obc.acta@med.vu.nl
Jörning
G G
GG
Chamuleau
R A
RA
D000818:Animals; D006498:Hepatectomy; D008099:Liver / Q000502:physiology*; D008297:Male; D008715:Methionine / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D013654:Taurine / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood / Q000652:urine*; D013997:Time Factors; D014018:Tissue Distribution
D013654:Taurine; C003949:hypotaurine; D008715:Methionine