Antiphospholipids and pregnancy--a review.
The presence of antiphospholipid antibodies is associated with a clinical syndrome characterised by thrombocytopenia, recurrent arterial and venous thromboses and recurrent fetal loss. The etiology is unknown but leads to an abnormal autoimmune response. Platelet aggregation and thrombosis follow. The mainstay of treatment is low dose aspirin, heparin and corticosteroids.
Yap
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Department of Obstetrics & Gynaecology, Singapore General Hospital, Singapore.
Yeoh
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Viegas
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OA
D000026:Abortion, Habitual / Q000209:etiology / Q000517:prevention & control; D017152:Antibodies, Antiphospholipid / Q000032:analysis; D000925:Anticoagulants / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis*; D013921:Thrombocytopenia / Q000209:etiology / Q000517:prevention & control; D013927:Thrombosis / Q000209:etiology / Q000517:prevention & control
D017152:Antibodies, Antiphospholipid; D000925:Anticoagulants