The HIV-1 Rev protein.
The nuclear export of intron-containing HIV-1 RNA is critically dependent on the activity of Rev, a virally encoded sequence-specific RNA-binding protein. Rev shuttles between the nucleus and the cytoplasm and harbors both a nuclear localization signal and a nuclear export signal. These essential peptide motifs have now been shown to function by accessing cellular signal-mediated pathways for nuclear import and nuclear export. HIV-1 Rev therefore represents an excellent system with which to study aspects of transport across the nuclear envelope.
Pollard
V W
VW
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia 19104-6148, USA. pollard@hhmi.upenn.edu
Malim
M H
MH
D017398:Alternative Splicing; D000595:Amino Acid Sequence; D002352:Carrier Proteins / Q000032:analysis / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D002467:Cell Nucleus / Q000378:metabolism; D015967:Gene Expression Regulation, Viral; D015694:Gene Products, rev / Q000032:analysis / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D015658:HIV Infections / Q000628:therapy; D015497:HIV-1 / Q000737:chemistry*; D006801:Humans; D028884:Karyopherins; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000378:metabolism; D012367:RNA, Viral / Q000737:chemistry / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear; D015534:Trans-Activators; D054321:rev Gene Products, Human Immunodeficiency Virus; D000097606:Exportin 1 Protein
D002352:Carrier Proteins; D015694:Gene Products, rev; D028884:Karyopherins; D012333:RNA, Messenger; D012367:RNA, Viral; D018160:Receptors, Cytoplasmic and Nuclear; D015534:Trans-Activators; D054321:rev Gene Products, Human Immunodeficiency Virus; D000097606:Exportin 1 Protein