title: Interleukin-4 receptor signalling mechanisms and their biological significance.
abstract: These studies describe key elements of the means through which the IL-4 receptor transduces functions of IL-4 and show relationships between these biochemical events and the major biological consequences of IL-4 action. In large measure, the control of IL-4-mediated growth and gene activation are segregated to different regions of the cytosolic domain of the receptor. These regions function by interacting with specific signaling molecules, leading to the activation of these molecules and the intracellular signaling pathways that result in the observed biological effects of IL-4.
authors.affiliation: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
authors.forename: K
authors.initials: K
authors.lastname: Nelms
authors.forename: H
authors.initials: H
authors.lastname: Huang
authors.forename: J
authors.initials: J
authors.lastname: Ryan
authors.forename: A
authors.initials: A
authors.lastname: Keegan
authors.forename: W E
authors.initials: WE
authors.lastname: Paul
mesh_terms: D000818:Animals; D006801:Humans; D015847:Interleukin-4 / Q000276:immunology; D008213:Lymphocyte Activation; D019948:Receptors, Interleukin-4 / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D019948:Receptors, Interleukin-4; D015847:Interleukin-4