Diversity and complexity of ceramide signalling in apoptosis.
Sphingolipid ceramide has emerged as a lipid messenger of cell functions including differentiation and apoptosis. Diverse kinds of stresses (ultraviolet, irradiation, heat shock and hypoxia) and biological factors (TNF-alpha, IFN-gamma and Fas antibody) require ceramide generation to execute apoptosis. The review summarises the diversity and complexity of up- and downstream of ceramide signalling in apoptosis and clinical implications of ceramide-induced apoptosis.
Okazaki
T
T
Department of Hematology/Oncology, Graduate School of Medicine, Kyoto University, Japan. toshiroo@kuhp.kyoto-u.ac.jp
Kondo
T
T
Kitano
T
T
Tashima
M
M
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002518:Ceramides / Q000502:physiology*; D006801:Humans; D015290:Second Messenger Systems / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D013107:Sphingolipids / Q000502:physiology
D002518:Ceramides; D013107:Sphingolipids