title: [The pharmacogenetic concept of the anxio-selective effect].
abstract: Hereditary variations in the effects of benzodiazepine tranquilizers depending on the phenotype of an emotional stress reaction (ESR) are described. The membrane-receptor relationship showed differences between C57B1/6 with an "active" ESR phenotype and Balb/c with a "passive" ESR at the GABA benzodiazepine receptor complex level. The pharmacological results evidenced the selective anxiolytic properties of the novel drug aphobazole (2-[2-morpholyno)ethylthio]-5-ethoxybenzimidazole dihydrochloride) which produced an activating anxiolytic action in Balb/c mice whereas no behavioral changes were observed in C57B1/6 mice.
authors.forename: S B
authors.initials: SB
authors.lastname: Seredenin
authors.forename: T A
authors.initials: TA
authors.lastname: Voronina
authors.forename: G G
authors.initials: GG
authors.lastname: Neznamov
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Blednov
authors.forename: B A
authors.initials: BA
authors.lastname: Badyshtov
authors.forename: I V
authors.initials: IV
authors.lastname: Viglinskaia
authors.forename: M M
authors.initials: MM
authors.lastname: Kozlovskaia
authors.forename: N V
authors.initials: NV
authors.lastname: Kolotilinskaia
authors.forename: M A
authors.initials: MA
authors.lastname: Iarkova
authors.forename: V L
authors.initials: VL
authors.lastname: Savel'ev
authors.forename: T L
authors.initials: TL
authors.lastname: Garibova
authors.forename: E A
authors.initials: EA
authors.lastname: Val'dman
mesh_terms: D000328:Adult; D000818:Animals; D014151:Anti-Anxiety Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D001569:Benzodiazepines; D003433:Crosses, Genetic; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects; D010597:Pharmacogenetics; D010641:Phenotype; D011600:Psychopharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D018709:Statistics, Nonparametric; D013315:Stress, Psychological / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology
chemical_list: D014151:Anti-Anxiety Agents; D001569:Benzodiazepines