Neutron capture therapy with a new boron-porphyrin compound in the rat 9L glioma model.
Neutron capture therapy with a new boron-porphyrin compound was tested in a rat brain tumor model. Although the concentration of boron in the tumor was too low to elicit a therapeutic effect, prominent histopathologic changes, such as necrosis, congestion and bleeding were observed in the tumors of the rats which were administered the boron neutron capture therapy.
Shibata
Y
Y
Dept. of Neurosurgery, University of Tsukuba, Toyo Hakka Co. Ltd., Ibaraki, Japan.
Matsumura
A
A
Yamamoto
T
T
Nakagawa
K
K
Yoshii
Y
Y
Nose
T
T
Sakata
I
I
Nakajima
S
S
Hayakawa
Y
Y
Ono
K
K
D000818:Animals; D016754:Boron Neutron Capture Therapy; D001932:Brain Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D018316:Gliosarcoma / Q000473:pathology / Q000532:radiotherapy*; D008665:Metalloporphyrins / Q000494:pharmacology*; D009336:Necrosis; D011879:Radiotherapy Dosage; D051381:Rats; D011916:Rats, Inbred F344; D016019:Survival Analysis
D008665:Metalloporphyrins; C117848:STA BX900