Sequence specificity of DNA cleavage by bisnetropsin-linked hydroxamic acid-metal complexes: highly specific cleavage by ferrous complexes.
Bisnetropsin-linked hydroxamic acids (BNHA) were shown to cleave DNA stands at a single residue with a preferred binding orientation in the presence of ferrous ion. In contrast, the corresponding cerium (III) complexes cleaved DNA with low sequence specificity.
Hashimoto
S
S
Department of Biological Science and Technology, Science University of Tokyo, Noda, Japan.
Nakamura
Y
Y
D001483:Base Sequence; D004269:DNA, Bacterial / Q000737:chemistry / Q000187:drug effects*; D005296:Ferrous Compounds / Q000737:chemistry / Q000494:pharmacology*; D006868:Hydrolysis; D006877:Hydroxamic Acids / Q000737:chemistry / Q000494:pharmacology*; D009429:Netropsin / Q000737:chemistry / Q000494:pharmacology*; D010957:Plasmids
D004269:DNA, Bacterial; D005296:Ferrous Compounds; D006877:Hydroxamic Acids; D009429:Netropsin