[Phenotypic variability in gag-myc transgenic mice].
The study of neoplastic growth capacity in gag-myc F3-F4 transgenic mice showed that they retain the capacity to develop hyperplasia and benign and malignant tumors same as F0-F2 transgenic mice do. However, the histological spectrum of tumors was much narrower, chiefly, due to the absence of rare patterns. The tumors in F3-F4 transgenic mice were mainly lymphomas and epithelial tumors of endocrine or exocrine glands. The incorporation of gag-myc in the genome of F3-F4 transgenic mice failed to tell on the variation of such quantitative polygenic characteristics as body mass and growth.
Ginkul
L B
LB
Institute of Cytology, Russian Academy of Sciences.
Ermilov
A N
AN
Mikulinskaia
S M
SM
Shvemberger
I N
IN
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D015992:Body Mass Index; D015750:Genes, gag; D016259:Genes, myc; D014644:Genetic Variation; D006128:Growth; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D020412:Multifactorial Inheritance; D009374:Neoplasms, Experimental / Q000235:genetics*; D013539:Simian virus 40 / Q000235:genetics; D019076:Transgenes