Hydroxylamine blocks adenosine A1 receptor-mediated inhibition of synaptic transmission in rat hippocampus.
The nitric oxide donor hydroxylamine (NH2OH) induced a transient depression of the evoked synaptic potential recorded in the rat hippocampal CA1 region. This depression was abolished with an adenosine A1 antagonist, 8-cyclopentyltheophylline. In addition, hydroxylamine reversed adenosine A1 receptor-mediated inhibition of the evoked population spike, the fEPSP and the intracellularly recorded EPSP. The inhibitory modulation of adenosine A1 receptor activation by hydroxylamine suggests the presence of a potent endogenous regulatory site.
Fowler
J C
JC
Department of Physiology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.phyjcf@ttuhsc.edu
Partridge
L D
LD
Gervitz
L
L
D000818:Animals; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D019811:Hydroxylamine / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009433:Neural Inhibition / Q000187:drug effects*; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology; D018408:Patch-Clamp Techniques; D058915:Purinergic P1 Receptor Antagonists; D051381:Rats; D017207:Rats, Sprague-Dawley; D018047:Receptors, Purinergic P1 / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects*
D058915:Purinergic P1 Receptor Antagonists; D018047:Receptors, Purinergic P1; D019811:Hydroxylamine