title: Characterization of a new HLA-B39 allele, B*3913, in a Brazilian Caucasian.
abstract: A panel of samples, previously typed by serology, was retyped using a line probe assay. One sample from a Brazilian Caucasian individual was serologically typed as B52/B39, but showed an aberrant HLA-B pattern on the diagnostic strip and was typed as B*52012/B*39new. Further analysis by allele-specific amplification and subsequent sequencing of exons 2 and 3 revealed a G(B*3908)-to-T nucleotide substitution at position 467 (codon 156) resulting in an Arg (B*3908)-to-Leu substitution. Furthermore, the sequence revealed a silent mutation at position 174 (codon 58): a G(B*3908)-to-A nucleotide switch. The sequence has been sent to the EMBL databank and the HLA Nomenclature Committee, and the allele was named B*3913.
authors.affiliation: Innogenetics N.V., Ghent, Belgium.
authors.forename: R
authors.initials: R
authors.lastname: Maertens
authors.forename: I
authors.initials: I
authors.lastname: De Canck
authors.forename: M E
authors.initials: ME
authors.lastname: Moraes
authors.forename: N
authors.initials: N
authors.lastname: Vande Casteele
authors.forename: G
authors.initials: G
authors.lastname: Van Reybroeck
authors.forename: B
authors.initials: B
authors.lastname: Vanderborght
authors.forename: J R
authors.initials: JR
authors.lastname: Moraes
authors.forename: R
authors.initials: R
authors.lastname: Rossau
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D001483:Base Sequence; D001938:Brazil; D018076:DNA, Complementary; D015235:HLA-B Antigens / Q000235:genetics*; D059946:HLA-B39 Antigen; D006801:Humans; D008969:Molecular Sequence Data; D044465:White People / Q000235:genetics*
chemical_list: D018076:DNA, Complementary; D015235:HLA-B Antigens; D059946:HLA-B39 Antigen