fMLP-OMe analogs substituted at the methionine residue: an insight into the receptor properties.
In order to obtain an insight into the mode of binding at the for-Met-Leu-Phe-OH (fMLP) receptor, three fMLP-OMe analogs (1-3) were synthesized in which the Met residue was substituted by Gln 1, Asn 2, and Ser 3. We evaluated the influence of the charge variation and/or the shift of its position on neutrophil biological responses.
Cavicchioni
G
G
Department of Pharmaceutical Sciences, University of Ferrara, Italy.
Monesi
L G
LG
Ferretti
M E
ME
Fabbri
E
E
Rizzuti
O
O
Spisani
S
S
D002630:Chemotactic Factors / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects; D044042:Receptors, Formyl Peptide; D011971:Receptors, Immunologic / Q000187:drug effects* / Q000378:metabolism; D018000:Receptors, Peptide / Q000187:drug effects* / Q000378:metabolism; D013329:Structure-Activity Relationship
D002630:Chemotactic Factors; D044042:Receptors, Formyl Peptide; D011971:Receptors, Immunologic; D018000:Receptors, Peptide; D009240:N-Formylmethionine Leucyl-Phenylalanine