title: Distinct recognition of non-clade B human immunodeficiency virus type 1 epitopes by cytotoxic T lymphocytes generated from donors infected in Africa.
abstract: We present detailed studies of human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte (CTL) responses to clade A or C HIV type 1 in three donors infected in East Africa. We define several novel non-clade B CTL epitopes, including some restricted by HLA alleles common in Africans. Although cross-clade CTL recognition of these epitopes does occur, recognition can also be highly clade specific.
authors.affiliation: Molecular Immunology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom.
authors.forename: L
authors.initials: L
authors.lastname: Dorrell
authors.forename: T
authors.initials: T
authors.lastname: Dong
authors.forename: G S
authors.initials: GS
authors.lastname: Ogg
authors.forename: S
authors.initials: S
authors.lastname: Lister
authors.forename: S
authors.initials: S
authors.lastname: McAdam
authors.forename: T
authors.initials: T
authors.lastname: Rostron
authors.forename: C
authors.initials: C
authors.lastname: Conlon
authors.forename: A J
authors.initials: AJ
authors.lastname: McMichael
authors.forename: S L
authors.initials: SL
authors.lastname: Rowland-Jones
mesh_terms: D000351:Africa, Eastern; D000595:Amino Acid Sequence; D002478:Cells, Cultured; D018984:Epitopes, T-Lymphocyte / Q000276:immunology*; D005260:Female; D015658:HIV Infections / Q000276:immunology / Q000821:virology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
chemical_list: D018984:Epitopes, T-Lymphocyte