Low-grade endometrial stromal sarcoma preoperative treatment with Depo-Lupron and Megace.
A 46-year-old women presented with an inoperable low-grade endometrial stromal sarcoma. Two doses of Depo-Lupron, 7.5 mg, and Megace, 160 mg/day, were given to control uterine bleeding and shrink the tumor mass. In 9 weeks, significant reduction in the tumor occurred allowing for surgical resection. Total abdominal hysterectomy with bilateral salpingo-oophorectomy is the mainstay for primary treatment. The role of chemotherapy, radiation therapy, and hormonal therapy is poorly defined. This is a case report of neoadjuvant hormonal therapy which may improve outcomes in patients with endometrial stromal sarcomas. Additional research is needed to define the exact role of these agents.
Scribner
D R
DR
Department of Gynecologic Oncology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, 73190, USA.
Walker
J L
JL
D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D016889:Endometrial Neoplasms / Q000188:drug therapy*; D005260:Female; D006801:Humans; D016729:Leuprolide / Q000627:therapeutic use*; D019290:Megestrol Acetate / Q000627:therapeutic use*; D008875:Middle Aged; D018203:Sarcoma, Endometrial Stromal / Q000188:drug therapy*
D018931:Antineoplastic Agents, Hormonal; D016729:Leuprolide; D019290:Megestrol Acetate