Abnormal myocardial adrenergic nerve function in orthostatic hypotension.
A 70-year-old man had frequent syncope and faintness when in an upright position. A diagnosis of primary orthostatic hypotension was obtained by a head-up tilt test and various autonomic nerve function tests. No abnormalities were seen on myocardium scintigraphy using 201Tl. However, 123I-metaiodobenzyl-guanidine did not accumulate in the heart. This suggests that globally denervated myocardium may impair a prompt increase in cardiac contractility and fail to maintain cerebral blood flow, thereby contributing to postural hypotension in this disorder.
Nakamura
M
M
Second Department of Internal Medicine, Iwate Medical University, Morioka, Japan. nkmrmoto@iwate-med.ac.jp
Yamazaki
T
T
Hiramori
K
K
D019797:3-Iodobenzylguanidine; D000320:Adrenergic Fibers; D000368:Aged; D001794:Blood Pressure; D002560:Cerebrovascular Circulation; D006321:Heart / Q000000981:diagnostic imaging / Q000294:innervation*; D006801:Humans; D007024:Hypotension, Orthostatic / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D011187:Posture; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013564:Sympathetic Nervous System / Q000503:physiopathology*; D013575:Syncope / Q000150:complications / Q000503:physiopathology
D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine