title: 9-cis retinoic acid induces the expression of the uncoupling protein-2 gene in brown adipocytes.
abstract: The expression of uncoupling protein-2 (UCP2) mRNA is up-regulated during the differentiation of brown adipocytes in primary culture. When differentiation of brown adipocytes is impaired, UCP2 mRNA expression is down-regulated. 9-cis Retinoic acid causes a dose-dependent induction of UCP2 mRNA levels in brown adipocytes, whereas all-trans retinoic acid has no effect. Specific agonists of retinoid X receptors (RXR) induce UCP2 mRNA expression, whereas specific activators of retinoic acid receptors do not. 9-cis Retinoic acid, acting through RXR receptors, is identified as a major regulator of the expression of the UCP2 gene in the brown fat cell.
authors.affiliation: Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Spain.
authors.forename: M C
authors.initials: MC
authors.lastname: Carmona
authors.forename: A
authors.initials: A
authors.lastname: Valmaseda
authors.forename: R
authors.initials: R
authors.lastname: Iglesias
authors.forename: T
authors.initials: T
authors.lastname: Mampel
authors.forename: O
authors.initials: O
authors.lastname: Viñas
authors.forename: M
authors.initials: M
authors.lastname: Giralt
authors.forename: F
authors.initials: F
authors.lastname: Villarroya
mesh_terms: D017667:Adipocytes / Q000187:drug effects* / Q000378:metabolism; D002001:Adipose Tissue, Brown / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D000077556:Alitretinoin; D000818:Animals; D005786:Gene Expression Regulation / Q000187:drug effects*; D006728:Hormones / Q000819:agonists; D007473:Ion Channels; D026901:Membrane Transport Proteins; D051379:Mice; D024101:Mitochondrial Proteins; D011506:Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000187:drug effects / Q000378:metabolism; D014212:Tretinoin / Q000494:pharmacology*; D000071246:Uncoupling Protein 2
chemical_list: D006728:Hormones; D007473:Ion Channels; D026901:Membrane Transport Proteins; D024101:Mitochondrial Proteins; D011506:Proteins; D012333:RNA, Messenger; C000604390:Ucp2 protein, mouse; D000071246:Uncoupling Protein 2; D000077556:Alitretinoin; D014212:Tretinoin