title: Myringosclerosis develops within 9h of myringotomy.
abstract: The aim of the present experimental study was to elucidate the temporal development of myringosclerosis. Twenty-four Sprague-Dawley rats were myringotomized bilaterally. At 3, 6, 9, 12, 18, 24, 30, 36, 48, 60, 72 and 84 h after the myringotomy, 2 animals at each time were examined otomicroscopically and thereafter sacrificed. The pars flaccida and pars tensa were excised and prepared for light- and electron-microscopic studies. Otomicroscopically, myringosclerosis was visible in the pars tensa 24 h after myringotomy, whereas no sclerotic lesions were noted in the pars flaccida. Histologically, sclerotic lesions were present in the pars tensa and pars flaccida 9 and 12 h, respectively, after myringotomy. The pars flaccida responds promptly with an inflammatory reaction characterized by abundant macrophages. Myringosclerosis develops promptly after myringotomy and its establishment is related to an inflammatory reaction.
authors.affiliation: Department of Otorhinolaryngology, University Hospital of Umeâ, Sweden. cecilia.mattsson@ent.umu.se
authors.forename: C
authors.initials: C
authors.lastname: Mattsson
authors.forename: C
authors.initials: C
authors.lastname: Johansson
authors.forename: S
authors.initials: S
authors.lastname: Hellström
mesh_terms: D000818:Animals; D003238:Connective Tissue / Q000473:pathology; D004195:Disease Models, Animal; D004848:Epithelium / Q000473:pathology; D005500:Follow-Up Studies; D008214:Lymphocytes / Q000473:pathology; D008264:Macrophages / Q000473:pathology; D008297:Male; D008307:Malleus / Q000473:pathology; D008854:Microscopy, Electron; D009504:Neutrophils / Q000473:pathology; D010033:Otitis Media / Q000209:etiology / Q000473:pathology; D010040:Otosclerosis / Q000209:etiology* / Q000473:pathology; D011183:Postoperative Complications; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014432:Tympanic Membrane / Q000473:pathology* / Q000601:surgery