Pre-emptive glycopyrrolate 0.2 mg and bradycardia during gynaecological laparoscopy with mivacurium.
In a prospective, randomized, double-blind, placebo-controlled trial, the effect of pre-emptive glycopyrrolate 0.2 mg given intravenously on the incidence of bradycardia in patients undergoing elective gynaecological laparoscopy with mivacurium neuromuscular blockade was investigated. Seven out of 32 (21.6%) control patients developed bradycardia (heart rate < 50 min-1), compared with 3 of 31 (9.6%) patients receiving glycopyrrolate (P = 0.4). Glycopyrrolate 0.2 mg, given immediately before induction in gynaecological laparoscopy with mivacurium, did not significantly reduce the incidence of intraoperative bradycardia.
Ambrose
C
C
Department of Anaesthesia, Coombe Women's Hospital, Dublin, Ireland, UK.
Buggy
D
D
Farragher
R
R
Troy
A
A
McNulty
C
C
Carey
M
M
D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage*; D001919:Bradycardia / Q000209:etiology / Q000517:prevention & control*; D004311:Double-Blind Method; D005260:Female; D006024:Glycopyrrolate / Q000008:administration & dosage*; D013509:Gynecologic Surgical Procedures; D006801:Humans; D007431:Intraoperative Complications / Q000517:prevention & control*; D007546:Isoquinolines / Q000009:adverse effects; D010535:Laparoscopy; D000077590:Mivacurium; D018727:Muscarinic Antagonists / Q000008:administration & dosage*; D003473:Neuromuscular Nondepolarizing Agents / Q000009:adverse effects; D011446:Prospective Studies
D000889:Anti-Arrhythmia Agents; D007546:Isoquinolines; D018727:Muscarinic Antagonists; D003473:Neuromuscular Nondepolarizing Agents; D000077590:Mivacurium; D006024:Glycopyrrolate