title: Patterns of uterine enhancement with helical CT.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the enhancement characteristics of the normal uterine body and cervix using dynamic contrast-enhanced helical CT.
  
  
  METHODS
  Thirty-eight women scheduled for pelvic CT for non-gynecologic malignancies underwent dynamic contrast-enhanced helical CT of the pelvis. Data acquisition was during the arterial phase (30-45 s after the start of injection), the parenchymal phase (90-120 s after the start of injection), and delayed phase (3-9 min after the start of injection). The images were evaluated by four radiologists for the pattern of myometrial and cervical enhancement. Correlation was made with the age and menstrual status of the patients.
  
  
  RESULTS
  In the uterine body, three types of enhancement were observed. Type 1 enhancement, seen in 16 patients (42%), was characterized by the visualization of a subendometrial zone of enhancement, 30-120 s after the start of injection. Eight of these patients also showed an enhancing zone in the outer myometrium. Both zones were transitory, and in all cases, the uterus became homogeneous in the delayed phase. This pattern was seen predominantly in premenopausal women with a mean age of 34 years. Type 2 enhancement, seen in 17 cases (45%), was defined by the absence of subendometrial enhancement in the early phase. Enhancement was either diffuse from the outset or originated in the outer myometrium. This pattern was seen nearly equally in premenopausal and postmenopausal women with a mean age of 40 years. Type 3 enhancement was seen in five postmenopausal patients (13%) with a mean age of 53 years and was characterized by faint diffuse enhancement. In the cervix, a zonal pattern of enhancement defining inner and outer stroma was seen in 23 patients (61%). Fifteen patients were premenopausal and eight were postmenopausal.
  
  
  CONCLUSIONS
  In this study, we have shown a transitory zonal distribution of the contrast in the myometrium and cervix using dynamic contrast-enhanced helical CT. The demonstration of these patterns is not constant and depends on individual variables. Of these, the menopausal status and/or age of the patient appear to be most important. While CT is not the primary imaging modality to evaluate the uterus, knowledge of these normal findings might help when confronted with unusual uterine enhancement during routine studies obtained with spiral CT.
authors.affiliation: Department of Diagnostic Radiology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
authors.forename: H
authors.initials: H
authors.lastname: Kaur
authors.forename: E M
authors.initials: EM
authors.lastname: Loyer
authors.forename: M
authors.initials: M
authors.lastname: Minami
authors.forename: C
authors.initials: C
authors.lastname: Charnsangavej
mesh_terms: D000328:Adult; D000368:Aged; D002584:Cervix Uteri / Q000000981:diagnostic imaging; D003287:Contrast Media; D005260:Female; D006801:Humans; D007047:Hysterosalpingography / Q000379:methods*; D007472:Iohexol; D008875:Middle Aged; D009215:Myometrium / Q000000981:diagnostic imaging; D017698:Postmenopause; D017697:Premenopause; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014599:Uterus / Q000033:anatomy & histology
chemical_list: D003287:Contrast Media; D007472:Iohexol