Expression of cyclin E in gynecologic malignancies.
OBJECTIVE
This study investigated the patterns of expression of cyclin E in clear cell carcinoma and other gynecological cancers.


METHODS
Immunohistochemistry was performed on paraffin-embedded archival specimens of ovarian, endometrial, cervical, and renal carcinomas.


RESULTS
Expression of cyclin E was evident in epithelial ovarian carcinomas utilizing immunohistochemistry. Immunohistochemistry revealed a high level of expression of cyclin E in a subset of gynecologic carcinomas, namely clear cell carcinomas, but not in clear cell carcinomas of renal origin.


CONCLUSIONS
These data suggest that an elevated level of immunohistochemical activity of cyclin E is a property of clear cell carcinomas of Müllerian origin. Immunohistochemistry with anti-cyclin E antibodies may serve as a useful method for diagnosing gynecologic clear cell carcinomas. Future studies are needed to confirm a possible increased activity of cyclin E in clear cell tumors.
Session
D R
DR
Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, New York, 10032, USA.
Lee
G S
GS
Choi
J
J
Wolgemuth
D J
DJ
D018262:Adenocarcinoma, Clear Cell / Q000378:metabolism*; D019927:Cyclin E / Q000096:biosynthesis*; D018844:Cyclin-Dependent Kinases / Q000096:biosynthesis; D016889:Endometrial Neoplasms / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D010051:Ovarian Neoplasms / Q000378:metabolism*; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis; D002583:Uterine Cervical Neoplasms / Q000378:metabolism
D019927:Cyclin E; D018809:Proliferating Cell Nuclear Antigen; D018844:Cyclin-Dependent Kinases