title: A prospective study of maternal serum insulin-like growth factor-I in pregnancies with appropriately grown or growth restricted fetuses.
abstract: OBJECTIVE
  To determine whether there is a relationship between maternal serum insulin-like growth factor-I and fetal growth, consistent with the hypothesis that insulin-like growth factor-I influences maternal constraint upon fetal growth by controlling placental transfer.
  
  
  METHODS
  A prospective, observational study.
  
  
  METHODS
  Fetal medicine unit and antenatal clinic of a large teaching hospital.
  
  
  METHODS
  One hundred and forty-one pregnant women identified as having small or normally grown fetuses.
  
  
  METHODS
  Fetuses were scanned every two weeks with maternal venesection at each visit. Cases (birthweight < 5th centile) were assigned to two groups: fetal growth restriction due to placental dysfunction (umbilical artery Doppler, growth velocity pulsatility index > +2 SD; n = 25) and normal small-for-gestational-age (normal Doppler, growth velocity and amniotic fluid; n = 27). Eighty-nine controls had birthweights between the 5th and the 95th centiles, normal Doppler, growth velocity and amniotic fluid. Insulin-like growth factor-I was measured by radioimmunoassay, and its relationship to gestational age and birthweight was assessed by regression analysis. Comparisons between case groups were made by Student's t test or analysis of covariance to allow for the effect of birthweight.
  
  
  METHODS
  The last insulin-like growth factor-I level before delivery within the different subgroups.
  
  
  RESULTS
  In controls, maternal insulin-like growth factor-I increased with gestational age (r = 0.40; P = 0.0001) but did not correlate with birthweight. Insulin-like growth factor-I was low in the mothers of growth restricted fetuses (-1.56 SD; P = 0.0001), but not in those with small-for-gestational age fetuses.
  
  
  CONCLUSIONS
  The control and small-for-gestational-age data suggest that maternal insulin-like growth factor-I is not associated with endocrine control of normal placental function. Low insulin-like growth factor-I relates to poor placental transfer, as indicated by Doppler, rather than to low birthweight. Whether this is a regulatory mechanism, a cause or a consequence of placental dysfunction needs further study.
authors.affiliation: Fetal Medicine Research Unit, University of Bristol, St Michael's Hospital, UK.
authors.forename: R P
authors.initials: RP
authors.lastname: Holmes
authors.forename: J M
authors.initials: JM
authors.lastname: Holly
authors.forename: P W
authors.initials: PW
authors.lastname: Soothill
mesh_terms: D015415:Biomarkers / Q000097:blood; D001724:Birth Weight; D005314:Embryonic and Fetal Development / Q000502:physiology*; D005260:Female; D005317:Fetal Growth Retardation / Q000378:metabolism*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D011247:Pregnancy; D011446:Prospective Studies
chemical_list: D015415:Biomarkers; D007334:Insulin-Like Growth Factor I