[Treatment and prognosis of nontuberculous mycobacterial pulmonary infection].
In performing NTM chemotherapy, particularly to mycobacterium avium-intracellulare complex (MAC) infection, we find difficulty in planning a rational protocol, and thus depend on previous experiences. We have studied retrospectively the effects of previous combination chemo-therapy cases of pulmonary MAC infections at National Tokyo Hospital. We selected 135 cases which had received the same chemotherapy continuously over six months. Having set a mean CFU of 3 times sputum culture before treatment as 100%, we calculated a six-months sequential bacillary response to a regimen and plotted the bacillary response curves. The response curves of various regimens of multidrug chemotherapy indicate that combinations of more than 3 drugs including aminoglycoside and clarithromycin are effective. The survival curve of 104 cases which could be observed over 10 years showed that median survival time is about 10 years.
Kurashima
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A
Department of Respiratory Medicine, National Tokyo Hospital.
D006801:Humans; D009165:Mycobacterium Infections, Nontuberculous / Q000188:drug therapy*; D015270:Mycobacterium avium-intracellulare Infection / Q000188:drug therapy; D011379:Prognosis; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*