Syndecan proteoglycans and cell adhesion.
It is now becoming clear that a family of transmembrane proteoglycans, the syndecans, have important roles in cell adhesion. They participate through binding of matrix ligand to their glycosaminoglycan chains, clustering, and the induction of signaling cascades to modify the internal microfilament organization. Syndecans can modulate the type of adhesive responses induced by other matrix ligand-receptor interactions, such as those involving the integrins, and so contribute to the control of cell morphology, adhesion and migration.
Woods
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Department of Cell Biology and the Cell Adhesion and Matrix Research Center, University of Alabama at Birmingham, 35294-0019, USA.
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Couchman
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D000595:Amino Acid Sequence; D000818:Animals; D002448:Cell Adhesion / Q000502:physiology*; D002462:Cell Membrane / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D003599:Cytoskeleton / Q000378:metabolism; D006497:Heparan Sulfate / Q000502:physiology; D006801:Humans; D008562:Membrane Glycoproteins / Q000502:physiology*; D008969:Molecular Sequence Data; D011509:Proteoglycans / Q000502:physiology*; D053667:Syndecans
D006497:Heparan Sulfate; D008562:Membrane Glycoproteins; D011509:Proteoglycans; D053667:Syndecans