title: Liver and spleen MRI findings in virus-associated hemophagocytic syndrome in a patient with acute lymphocytic leukemia.
abstract: Virus-associated hemophagocytic syndrome is characterized by the phagocytosis of erthythrocytes and other blood elements in multiple organ systems, especially the liver and spleen. Magnetic resonance imaging (MRI) can suggest this diagnosis in the proper clinical setting by demonstrating multiple, rounded signal voids in the spleen corresponding to hemosiderin deposition. We report a patient with virus-associated hemophagocytic syndrome during the course of acute lymphocytic leukemia and MRI findings that suggested the preoperative diagnosis.
authors.affiliation: Division of Pediatric Radiology, Schneider Children's Hospital, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA.
authors.forename: A
authors.initials: A
authors.lastname: Zilkha
authors.forename: V
authors.initials: V
authors.lastname: Madan
authors.forename: J C
authors.initials: JC
authors.lastname: Leonidas
authors.forename: E
authors.initials: E
authors.lastname: Valderrama
mesh_terms: D002675:Child, Preschool; D005260:Female; D015616:Histiocytosis, Non-Langerhans-Cell / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008099:Liver / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications*; D013154:Spleen / Q000473:pathology*; D014777:Virus Diseases / Q000150:complications*