title: Hemolysin as a virulence factor for systemic infection with isolates of Mycobacterium avium complex.
abstract: Isolates of the Mycobacterium avium complex were examined for hemolysin expression. Only invasive isolates of M. avium were observed to be hemolytic (P < 0.001), with activity the greatest for isolates of serovars 4 and 8. Thus, M. avium hemolysin appears to represent a virulence factor necessary for invasive disease.
authors.affiliation: Infectious Diseases Section, Medical Service, VA Medical Center, and Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02130, USA. maslow.joel_n.md@boston.va.gov
authors.forename: J N
authors.initials: JN
authors.lastname: Maslow
authors.forename: D
authors.initials: D
authors.lastname: Dawson
authors.forename: E A
authors.initials: EA
authors.lastname: Carlin
authors.forename: S M
authors.initials: SM
authors.lastname: Holland
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000382:microbiology; D006460:Hemolysin Proteins / Q000096:biosynthesis*; D006461:Hemolysis; D006801:Humans; D015269:Mycobacterium avium Complex / Q000302:isolation & purification / Q000378:metabolism / Q000472:pathogenicity*; D015270:Mycobacterium avium-intracellulare Infection / Q000382:microbiology*; D014774:Virulence
chemical_list: D006460:Hemolysin Proteins