Acquired factor VIII inhibitors--successful treatment with an oral outpatient regimen.
A rare cause of a spontaneous, life threatening coagulopathy in adults is the development of autoantibodies to factor VIII. We recently had the opportunity to treat seven patients with this disorder. After stabilization, they were given a regimen consisting of prednisone and oral cyclophosphamide. All patients had a complete response to treatment. The median time to response was three weeks. Durable remissions were achieved, making this oral regimen an acceptable treatment for this disorder.
Bayer
R L
RL
Department of Medicine, North Shore University Hospital-New York University School of Medicine, Manhasset 11030, USA.
Lichtman
S M
SM
Allen
S L
SL
Budman
D R
DR
Buchbinder
A
A
Fetten
J
J
Kolitz
J
J
Loscalzo
J
J
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000553:Ambulatory Care; D001323:Autoantibodies / Q000097:blood; D001327:Autoimmune Diseases / Q000188:drug therapy; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use; D004338:Drug Combinations; D005169:Factor VIII / Q000276:immunology*; D005260:Female; D006467:Hemophilia A / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use; D012074:Remission Induction
D001323:Autoantibodies; D004338:Drug Combinations; D003520:Cyclophosphamide; D005169:Factor VIII; D011241:Prednisone