[Pulmonary lymphangioleiomyomatosis (LAM). Diagnostic usefulness of immunohistochemical markers].
Lymphangioleiomyomatosis (LAM) is a rare disease of unknown cause affecting the lungs of female patients. Although clinical and radiological findings may suggest LAM, a firm diagnosis is usually made after lung biopsy. Cases of LAM (histochemical diagnosis) or "suggestive of LAM" at the "12 of October" Hospital are reviewed. We applied a battery of immunohistochemical tests not used to date--involving estrogen, progesterone, desmin and HMB45 receptors--that allowed us to classify specimens as having either LAM lesions or lesions with non-LAM muscle proliferation. Smooth muscle proliferation in LAM is a distinct phenotype, such that diagnosis is facilitated by analyzing for immunohistochemical markers such as HMB45. This marker can be detected on formalin-fixed paraffin-embedded sheets in specimens obtained by either open lung or transbronchial biopsy.
Serrano Pardo
R
R
Departamento de Anatomía Patológica, Hospital Universitario 12 de Octubre, Madrid.
Sotelo Rodríguez
M T
MT
Alvarez Martínez
C
C
Ballestin Carcavilla
C
C
Larrú Cabrero
E
E
D000328:Adult; D015415:Biomarkers; D001706:Biopsy; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008168:Lung / Q000473:pathology; D008171:Lung Diseases / Q000175:diagnosis* / Q000473:pathology; D018192:Lymphangioleiomyomatosis / Q000175:diagnosis* / Q000473:pathology; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed
D015415:Biomarkers