Multiple intracranial hemorrhages at the time of a transiently prolonged activated partial thromboplastin time in an infant with congenital factor VII deficiency.
Factor VII (FVII) deficiency is a rare autosomal recessive hereditary disorder characterized by a normal partial thromboplastin time and a prolonged prothrombin time. For definitive diagnosis, the specific FVII level should be investigated. We report on a 7-month-old boy with congenital FVII deficiency suffering from convulsions and intracerebral hemorrhage. Hematologic tests revealed prolonged prothrombin time associated with a decreased FVII level of 1.7%. Computerized tomography of the brain revealed multifocal hemorrhagic lesions. To our knowledge, multifocal intracranial hemorrhages at the time of a transiently prolonged partial thromboplastin time of unknown origin in a child with congenital FVII deficiency of about 2% has not been reported so far.
Erduran
E
E
Department of Pediatrics, Karadeniz Technical University, School of Medicine, Trabzon, Turkey.
Mocan
H
H
Aslan
Y
Y
Sari
A
A
D002543:Cerebral Hemorrhage / Q000097:blood / Q000209:etiology*; D005168:Factor VII Deficiency / Q000097:blood* / Q000151:congenital / Q000235:genetics*; D006801:Humans; D007223:Infant; D008297:Male; D010314:Partial Thromboplastin Time; D013997:Time Factors