title: IS990, a new species-specific insertion-sequence-related element of the Mycobacterium tuberculosis complex.
abstract: The structure and distribution of 1S990, a new Mycobacterium tuberculosis DNA sequence with homology to characterized insertion sequences (ISs), were investigated. IS990 was related to IS elements of the IS3 family and was present as a single copy in all 21 investigated M. tuberculosis strains, two Mycobacterium bovis strains and two M. bovis BCG strains. The sequence appears to be specific for the M. tuberculosis complex. The element carries two frameshift mutations and appears to be defective.
authors.affiliation: Centre for Microbiology and Virology, Polish Academy of Sciences, Lodowa 106, 93-232 Ldz, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Dziadek
authors.affiliation: Department of Genetics of Microorganisms, University of Ldz, Banacha 12/16, 93237 Ldz, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Sajduda
authors.affiliation: Molecular Microbiology Group, School of Biological Sciences, University of Surrey, Guildford GU2 5XH, UK.
authors.forename: J W
authors.initials: JW
authors.lastname: Dale
authors.affiliation: Molecular Microbiology Group, School of Biological Sciences, University of Surrey, Guildford GU2 5XH, UK.
authors.forename: J J
authors.initials: JJ
authors.lastname: McFadden
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D004251:DNA Transposable Elements / Q000235:genetics*; D004269:DNA, Bacterial / Q000032:analysis; D018628:Gene Dosage; D008969:Molecular Sequence Data; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity
chemical_list: D004251:DNA Transposable Elements; D004269:DNA, Bacterial