title: Anti-inflammatory benzopyran-2-ones and their active oxygen species (aos) scavenging activity.
abstract: Benzopyrano derivatives were synthesized and evaluated for their anti-inflammatory, ulcerogenic activities and toxicity studies. The in-vitro studies comprised of anti-proteolytic activity, lipid peroxidation inhibitory and reducing activities against alpha, alpha-diphenyl-beta-picrylhydrazyl (DPPH). Two potent compounds were studied further for their inhibition of lipid peroxidation and effect on Superoxide dismutase (SOD) activity in-vivo. These compounds were found promising in all the parameters studied, thereby signifying inter-relationship between their anti-inflammatory activity and anti-oxidant properties.
authors.affiliation: Department of Biochemistry, University of Lucknow, India.
authors.forename: M
authors.initials: M
authors.lastname: Bhalla
authors.forename: S
authors.initials: S
authors.lastname: Shukla
authors.forename: V R
authors.initials: VR
authors.lastname: Gujrati
authors.forename: A K
authors.initials: AK
authors.lastname: Saxena
authors.forename: K C
authors.initials: KC
authors.lastname: Sanger
authors.forename: K
authors.initials: K
authors.lastname: Shanker
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000494:pharmacology*; D001578:Benzopyrans / Q000138:chemical synthesis / Q000494:pharmacology*; D005260:Female; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001578:Benzopyrans; D016166:Free Radical Scavengers; D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase