title: Sex chromosomes: evolving dosage compensation.
abstract: Dosage compensation of some X-linked genes varies among mammals. Inactivation of an X-linked copy of a gene in females appears to correlate with lack of an active homologue on the Y chromosome, implying that dosage compensation evolves in response to the loss of function of genes on the Y.
authors.affiliation: Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, Edinburgh EH9 2BR, UK. Brian.Charlesworth@ed.ac.uk
authors.forename: B
authors.initials: B
authors.lastname: Charlesworth
mesh_terms: D000074063:ATP Binding Cassette Transporter, Subfamily D, Member 1; D018528:ATP-Binding Cassette Transporters / Q000235:genetics; D000818:Animals; D002874:Chromosome Mapping; D004268:DNA-Binding Proteins / Q000235:genetics; D004303:Dosage Compensation, Genetic; D019143:Evolution, Molecular; D018507:Gene Expression Regulation, Developmental; D008040:Genetic Linkage; D006801:Humans; D051741:Kruppel-Like Transcription Factors; D008565:Membrane Proteins / Q000235:genetics; D012730:Sex Chromosomes / Q000235:genetics*; D014157:Transcription Factors; D014960:X Chromosome / Q000235:genetics; D014998:Y Chromosome / Q000235:genetics
chemical_list: C115572:ABCD1 protein, human; D000074063:ATP Binding Cassette Transporter, Subfamily D, Member 1; D018528:ATP-Binding Cassette Transporters; D004268:DNA-Binding Proteins; D051741:Kruppel-Like Transcription Factors; D008565:Membrane Proteins; D014157:Transcription Factors; C054430:ZFY protein, human; C062076:zinc finger protein, X-linked