Ganciclovir-associated hypercalcemia in a renal transplant patient.
We describe a renal transplant patient who developed hypercalcemia during treatment with ganciclovir for cytomegaloviral (CMV) infection. To our knowledge such an association has not previously been reported. Hypercalcemia was associated with low levels of serum parathormone (PTH) and an increase in 1,25 dihydroxy vitamin D concentrations. The mechanism(s) of ganciclovir-associated hypercalcemia remains unclear.
Georgiev
O P
OP
Department of Internal Medicine, University of Missouri Health Sciences Center Columbia, 65212, USA.
Lal
S M
SM
Gupta
N
N
Ross
G
G
D000998:Antiviral Agents / Q000009:adverse effects*; D003586:Cytomegalovirus Infections / Q000188:drug therapy; D015774:Ganciclovir / Q000009:adverse effects*; D006801:Humans; D006934:Hypercalcemia / Q000097:blood / Q000139:chemically induced*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood
D000998:Antiviral Agents; D010281:Parathyroid Hormone; D014807:Vitamin D; C097949:1,25-dihydroxyvitamin D; D015774:Ganciclovir