title: Allergic colitis: a mimic of Hirschsprung disease.
abstract: BACKGROUND
  Allergy to cow milk protein is a common cause of gastrointestinal symptoms in infancy. Milk allergy is usually a clinical diagnosis, and thus there have been few reports of the radiographic findings.
  
  
  OBJECTIVE
  To describe the barium enema findings of allergic colitis and differentiate them from Hirschsprung disease. Materials and methods. Four infants (age range 7 days-5 weeks) with constipation underwent barium enema to exclude Hirschsprung disease. Radiographic findings were correlated with the pathologic specimens from suction rectal biopsy.
  
  
  RESULTS
  All enemas revealed irregular narrowing of the rectum and a transition zone. Rectal biopsies in each case demonstrated ganglion cells and evidence of an allergic colitis, with inflammatory infiltrates in the lamina propria. A diagnosis of milk allergy colitis was made and symptoms resolved after removal of milk from the diet.
  
  
  CONCLUSIONS
  Milk allergy is common in infancy. The rectum is a primary target organ, with allergic colitis often diagnosed on clinical grounds alone. However, a child with allergic colitis may be referred to radiology for barium enema, especially if constipation is present. The radiologist should be aware of the unique imaging findings of allergic colitis, so as to avoid confusion with Hirschsprung disease and perhaps an unnecessary rectal biopsy.
authors.affiliation: Department of Radiology, Children's Radiological Institute, Columbus Children's Hospital, 700 Children's Drive, Columbus OH 43205-2696, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Bloom
authors.forename: C
authors.initials: C
authors.lastname: Buonomo
authors.forename: S J
authors.initials: SJ
authors.lastname: Fishman
authors.forename: G
authors.initials: G
authors.lastname: Furuta
authors.forename: S
authors.initials: S
authors.lastname: Nurko
mesh_terms: D000818:Animals; D001466:Barium Sulfate / Q000008:administration & dosage; D001706:Biopsy; D003092:Colitis / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology; D003287:Contrast Media / Q000008:administration & dosage; D003937:Diagnosis, Differential; D004733:Enema; D005260:Female; D005500:Follow-Up Studies; D006627:Hirschsprung Disease / Q000150:complications / Q000000981:diagnostic imaging*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008892:Milk / Q000009:adverse effects / Q000276:immunology; D016269:Milk Hypersensitivity / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology; D011859:Radiography; D012007:Rectum / Q000000981:diagnostic imaging / Q000473:pathology; D012189:Retrospective Studies
chemical_list: D003287:Contrast Media; D001466:Barium Sulfate