[Clinical evaluation of the effectiveness of radiotherapy in vaginal metastases of uterine cancer].
The data on 132 patients with metastases of endometrial carcinoma into the vagina (MECV) were analysed. Among the modalities used were complex (remote + contact) and contact radiotherapy with low-, medium- and high dosage. The following radiobiological models were employed to assess tissue response: time-dose-fractionation factor, cumulative radiation effect and linear-quadratic dose effect equation ("extrapolated dose of response"). There was a correlation between five-year survival in radiation-treated patients and metastasis size. Stage of disease proved a major prognostic factor in MECV treatment. Complex radiotherapy was of crucial importance in MECV treatment whatever the size of disseminated tumor. There was no correlation between efficacy of MECV treatment and therapy used to treat primary endometrial carcinoma (surgery, combined or radiotherapy).
Kanaev
S V
SV
Prof. N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Turkevich
V G
VG
D001918:Brachytherapy; D003131:Combined Modality Therapy; D003627:Data Interpretation, Statistical; D019583:Dose Fractionation, Radiation; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D011879:Radiotherapy Dosage; D013997:Time Factors; D014594:Uterine Neoplasms / Q000401:mortality; D014625:Vaginal Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000556:secondary / Q000601:surgery