title: Chromatin disruption and modification.
abstract: Chromatin disruption and modification are associated with transcriptional regulation by diverse coactivators and corepressors. Here we discuss the possible structural basis and functional consequences of the observed alterations in chromatin associated with transcriptional activation and repression. Recent advances in defining the roles of individual histones and their domains in the assembly and maintenance of regulatory architectures provide a framework for understanding how chromatin remodelling machines, histone acetyltransferases and deacetylases function.
authors.affiliation: Laboratory of Molecular Embryology, Natational Institute of Child Health and Human Development, NIH, Building 18T, Room 106, Bethesda, MD 20892-5431, USA. awlme@helix.nih.gov
authors.forename: A P
authors.initials: AP
authors.lastname: Wolffe
authors.forename: J J
authors.initials: JJ
authors.lastname: Hayes
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002843:Chromatin / Q000502:physiology*; D006657:Histones / Q000235:genetics / Q000502:physiology; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009707:Nucleosomes / Q000502:physiology; D013329:Structure-Activity Relationship; D015533:Transcriptional Activation
chemical_list: D002843:Chromatin; D006657:Histones; D009707:Nucleosomes