The role of inherited thrombotic disorders in the etiology of Legg-Calvé-Perthes disease.
Inherited thrombophilia has been suggested as a cause of Legg-Calvé-Perthes disease in up to 75% of patients. This prevalence seems high compared to the prevalence of inherited thrombophilia in other thrombotic disorders (average, 30%). Therefore, we investigated 44 patients with Legg-Calvé-Perthes disease for antithrombin-III, protein-C, and protein-S deficiency and activated protein C (APC) resistance. Three (6.8%) of our patients were positive for APC resistance, and one patient (2.2%) showed deficiency of protein-C activity. Our results suggest that inherited thrombophilia is not associated with avascular necrosis of the femoral head (Legg-Calvé-Perthes disease).
Gallistl
S
S
Department of Pediatrics, University of Graz, Austria. Siegfried.gallistl@kfunigraz.ac.at
Reitinger
T
T
Linhart
W
W
Muntean
W
W
D020016:Activated Protein C Resistance / Q000150:complications; D000293:Adolescent; D000328:Adult; D000990:Antithrombin III / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007873:Legg-Calve-Perthes Disease / Q000097:blood / Q000209:etiology*; D008297:Male; D018455:Protein S Deficiency / Q000150:complications; D019851:Thrombophilia / Q000150:complications*
D000990:Antithrombin III