Nuclear import: a tale of two sites.
The recently determined crystal structure of a nuclear localization sequence receptor has revealed an exquisitely specific interaction between ligand and receptor, and explains how simple and complex nuclear localization signals can both be recognized specifically by the same molecule.
Dingwall
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Department of Pharmacology, State University of New York at Stony Brook, Stony Brook, New York 11794-8651, USA.
Laskey
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RA
D000818:Animals; D001665:Binding Sites / Q000502:physiology; D001692:Biological Transport / Q000502:physiology; D002467:Cell Nucleus / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D019913:Nuclear Localization Signals / Q000502:physiology*; D009687:Nuclear Proteins / Q000737:chemistry / Q000378:metabolism; D011485:Protein Binding / Q000502:physiology; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship; D028901:alpha Karyopherins
D019913:Nuclear Localization Signals; D009687:Nuclear Proteins; D028901:alpha Karyopherins