title: Langerhans' cell histiocytosis and juvenile xanthogranuloma of the orbit. Clinicopathologic, CT, and MR imaging features.
abstract: The clinical, radiologic, and histopathologic features of two main disorders of the orbit are discussed. Group I, Langerhans cell histiocytosis (histiocytosis X, Class I), is caused by proliferation of X histiocytic Langerhans' cells. Group II is juvenile xanthogranuloma, and Class II is related to the proliferation of non-X histiocytic (monocyte-macrophage) cells. The two diseases are of unknown cause and differ in their clinical, radiologic, and histopathologic features.
authors.affiliation: Department of Ophthalmic Pathology, Armed Forces Institute of Pathology, Washington, DC, USA.
authors.forename: A A
authors.initials: AA
authors.lastname: Hidayat
authors.forename: M F
authors.initials: MF
authors.lastname: Mafee
authors.forename: N V
authors.initials: NV
authors.lastname: Laver
authors.forename: S
authors.initials: S
authors.lastname: Noujaim
mesh_terms: D002455:Cell Division; D006644:Histiocytes / Q000473:pathology; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008264:Macrophages / Q000473:pathology; D008279:Magnetic Resonance Imaging; D009000:Monocytes / Q000473:pathology; D009916:Orbital Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014972:Xanthogranuloma, Juvenile / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology