Successful treatment of pustulosis palmaris et plantaris with granulocyte colony stimulating factor in a patient with hereditary neutropenia.
A 26-year-old female with hereditary neutropenia had Pustulosis Palmaris et Plantaris. Drug administration did not improve her symptoms. Following administration of granulocyte colony stimulating factor (G-CSF; filgrastim), her neutrophil count increased from 300 to 58,000/microliters, and her dermatosis improved. Pustulosis Palmaris et Plantaris has been described as a representative second lesion of focal infection. Neutropenia may be one cause of Pustulosis Palmaris et Plantaris due to refractory focal infection. In the present case, increase in neutrophils with G-CSF may have improved focal infection, resulting in improvement in refractory Pustulosis Palmaris et Plantaris.
Hino
M
M
Department of Clinical Hematology, Osaka City University Medical School, Japan.
Yamane
T
T
Kuwaki
T
T
Kono
T
T
Kitagawa
S
S
Tatsumi
N
N
D000328:Adult; D005192:Family Health; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D009503:Neutropenia / Q000150:complications* / Q000235:genetics; D011565:Psoriasis / Q000188:drug therapy* / Q000209:etiology*
D016179:Granulocyte Colony-Stimulating Factor