title: Independent recovery of memory and language functioning during the Intracarotid Sodium Amytal Test.
abstract: Memory and language recovery during the Intracarotid Sodium Amytal Test (IAP) was investigated in 49 left-hemisphere-dominant patients with unilateral temporal epileptic seizure foci. Memory was assessed by presenting items (words, objects, and faces) immediately after injection, and testing for recognition memory 10 min after motoric recovery. To assess language the patients responded verbally to the same items during memory presentation. Memory for the individual items was found to be independent of their presentation order and language functioning was impaired only with the dominant-hemisphere injection, recovering during the presentation of the memory items. These results suggest that the encoding of material remains at a constant level throughout the initial active phase of the IAP, whereas language functioning recovers independently.
authors.affiliation: Department of Clinical Psychology, Institute of Psychiatry, London, UK. spjtrgm@iop.kcl.ac.uk
authors.forename: R G
authors.initials: RG
authors.lastname: Morris
authors.forename: C E
authors.initials: CE
authors.lastname: Polkey
authors.forename: T
authors.initials: T
authors.lastname: Cox
mesh_terms: D000328:Adult; D000654:Amobarbital / Q000008:administration & dosage; D002343:Carotid Artery, Internal; D003071:Cognition / Q000187:drug effects; D004569:Electroencephalography / Q000187:drug effects; D017029:Epilepsy, Complex Partial / Q000523:psychology; D005260:Female; D007839:Functional Laterality / Q000187:drug effects; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage; D007269:Injections, Intra-Arterial; D007802:Language; D008297:Male; D008568:Memory / Q000187:drug effects*; D010291:Paresis / Q000139:chemically induced
chemical_list: D006993:Hypnotics and Sedatives; D000654:Amobarbital