[Discordant lymphoma: a report of 2 new cases and a review of the literature].
The simultaneous occurrence of two different histologic types of lymphoma in one location ("composite" lymphoma) or in different anatomical locations ("discordant" lymphoma) is uncommon, particularly the association of Hodgkin's disease (HD) and non-Hodgkin's disease (NHD). Therefore, both conditions have long been considered well differentiated entities, and its association qualified as a chance event. Two cases of "discordant" lymphoma are reported. In both cases the histologic type was HD with mixed cellularity, associated with immunoblastic B lymphoma in case 1 and CLL-B in case 2. Some recent series seem to indicate that this phenomenon occurs more commonly than what could be reasonably attributed to chance alone, suggesting the analysis of cases associating HD and NHD with CLL-B a possible clonal relationship between these conditions. The Reed-Sternberg cell might thus originate from an altered B-lymphocyte.
Azaceta Reinares
G
G
Servicio de Hematología, Hospital Clínico Universitario, Zaragoza.
Domingo Morera
J M
JM
Rabasa Baraibar
P
P
Palomera Bernal
L
L
D000368:Aged; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D005260:Female; D006689:Hodgkin Disease / Q000473:pathology* / Q000628:therapy; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000473:pathology* / Q000628:therapy; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology* / Q000628:therapy; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000628:therapy; D012008:Recurrence; D009626:Terminology as Topic