Treatment of functional dyspepsia.
Many functional dyspepsia treatment trials have until recently suffered from important weaknesses in study design. A major problem has been the low number of studies that have used validated outcome measures. Fortunately, progress has been made in this area. The evidence for the efficacy of antacids, H2-receptor antagonists, omeprazole, domperidone, cisapride and anti-Helicobacter therapy is reviewed. Although several of these have shown benefit, it is unclear whether this may be a result of the inclusion of patients with unrecognized gastro-oesophageal reflux disease. The data on anti-Helicobacter therapy are conflicting.
Veldhuyzen van Zanten
S J
SJ
Department of Medicine, Dalhousie University, QEII, Victoria General Hospital Site, Dr. R. C. Dickson Centre, Halifax, N.S., Canada.
D004415:Dyspepsia / Q000188:drug therapy*; D016481:Helicobacter Infections / Q000188:drug therapy; D016480:Helicobacter pylori; D006801:Humans; D016896:Treatment Outcome