title: Labial salivary gland biopsy for diagnosis of amyloid polyneuropathy.
abstract: Biopsies of peroneal nerve and labial salivary gland (LSG) were performed in 32 patients with polyneuropathy of unknown origin. Amyloid deposits were detected in 7 LSG (transthyretin=5; amyloid, light chain derived=2) and 6 nerve biopsies. Familial amyloid and light chain amyloid polyneuropathies were subsequently confirmed by relevant tests. We propose that LSG biopsy, a minimally invasive test that may document both sicca syndrome and amyloidosis, should be systematically performed in the investigation of patients with axonal polyneuropathies.
authors.affiliation: Département de Pathologie, Hôpital Henri Mondor, Créteil, France.
authors.forename: E
authors.initials: E
authors.lastname: Lechapt-Zalcman
authors.forename: F J
authors.initials: FJ
authors.lastname: Authier
authors.forename: A
authors.initials: A
authors.lastname: Creange
authors.forename: M C
authors.initials: MC
authors.lastname: Voisin
authors.forename: R K
authors.initials: RK
authors.lastname: Gherardi
mesh_terms: D000682:Amyloid / Q000032:analysis; D017772:Amyloid Neuropathies / Q000473:pathology*; D001706:Biopsy; D006801:Humans; D007150:Immunohistochemistry; D008046:Lip; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000473:pathology; D010543:Peroneal Nerve / Q000473:pathology; D011237:Predictive Value of Tests; D012470:Salivary Glands, Minor / Q000737:chemistry / Q000473:pathology*; D012680:Sensitivity and Specificity
chemical_list: D000682:Amyloid