Oxidative stress and the pathogenesis of heart failure.
There is strong evidence for an adverse role of oxidative stress in CHF in both animals and humans. Antioxidant supplement have been very effective in the treatment of animal paradigms; however, the data for the possible benefits of treatment for patients with CHF is either retrospective or inferential. Such information is important and should be the subject of prospective randomized trials.
Ball
A M
AM
Department of Medicine, University of Toronto, Ontario, Canada.
Sole
M J
MJ
D000818:Animals; D000975:Antioxidants; D006333:Heart Failure / Q000209:etiology*; D006801:Humans; D009206:Myocardium / Q000378:metabolism; D018384:Oxidative Stress; D017382:Reactive Oxygen Species
D000975:Antioxidants; D017382:Reactive Oxygen Species