title: Diminishing returns from mutation supply rate in asexual populations.
abstract: Mutator genotypes with increased mutation rates may be especially important in microbial evolution if genetic adaptation is generally limited by the supply of mutations. In experimental populations of the bacterium Escherichia coli, the rate of evolutionary adaptation was proportional to the mutation supply rate only in particular circumstances of small or initially well-adapted populations. These experiments also demonstrate a "speed limit" on adaptive evolution in asexual populations, one that is independent of the mutation supply rate.
authors.affiliation: Center for Microbial Ecology, Michigan State University, East Lansing, MI 48824, USA. arjan.devisser@algemeen.micr.wau.nl
authors.forename: J A
authors.initials: JA
authors.lastname: Arjan
authors.forename: M
authors.initials: M
authors.lastname: Visser
authors.forename: C W
authors.initials: CW
authors.lastname: Zeyl
authors.forename: P J
authors.initials: PJ
authors.lastname: Gerrish
authors.forename: J L
authors.initials: JL
authors.lastname: Blanchard
authors.forename: R E
authors.initials: RE
authors.lastname: Lenski
mesh_terms: D000222:Adaptation, Physiological; D005075:Biological Evolution; D004926:Escherichia coli / Q000235:genetics* / Q000502:physiology; D005828:Genetics, Population; D005838:Genotype; D016014:Linear Models; D008954:Models, Biological; D009154:Mutation