Fungal endocarditis in bone marrow transplantation: case report and review of literature.
We report a case of fungal endocarditis due to Aspergillus terreus in a leukaemia patient who received a bone marrow allograft from a matched unrelated donor. He presented with persistent fever. microangiopathic haemolytic anaemia but there was no cardiac signs and symptoms. He died despite intravenous amphotericin B. Review of the English literature showed five other patients with fungal endocarditis in the setting of bone marrow transplantation and revealed the same features of difficult diagnosis and poor outcome.
Chim
C S
CS
Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong.
Ho
P L
PL
Yuen
S T
ST
Yuen
K Y
KY
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000150:complications* / Q000188:drug therapy; D001230:Aspergillus / Q000187:drug effects / Q000254:growth & development; D016026:Bone Marrow Transplantation; D004696:Endocarditis / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000382:microbiology
D000935:Antifungal Agents; D000666:Amphotericin B