Topical timolol therapy in pregnancy: is it safe for the fetus?
At 21 weeks of gestation, a 37-year-old woman was referred to our hospital. The fetus showed bradycardia and arrhythmia. Because of glaucoma the woman had previously been treated with timolol eye drops. In this paper a possible association between the timolol eye drops and the fetal cardiac arrhythmia is discussed.
Wagenvoort
A M
AM
Department of Obstetrics and Gynecology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands.
van Vugt
J M
JM
Sobotka
M
M
van Geijn
H P
HP
D000328:Adult; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D001919:Bradycardia / Q000139:chemically induced*; D004562:Electrocardiography; D005260:Female; D005315:Fetal Diseases / Q000139:chemically induced*; D005901:Glaucoma / Q000188:drug therapy*; D006801:Humans; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D013999:Timolol / Q000009:adverse effects*
D013999:Timolol