title: Natural defenses and autoprotection: naturotherapy, an old concept of healing in a new perspective.
abstract: Recent molecular-biological and molecular-genetic research has shown that important cellular-based autoprotective mechanisms are mediated by heat-shock proteins (HSPs) or stress-response proteins, also called 'chaperones'. This can happen because cells react to extracellular stimuli by activating signal transduction pathways which result in activating the genetic program. Molecular biologists and cardiologists are tempted to evaluate these phenomena in respect to their potential meaning for a better understanding of the complex notions of health and disease. When molecular geneticists or cardiologists talk about autoprotective or natural defense mechanisms, and physicians talk about salutogenesis, they all mean something very specific. The phenomenon seen here belongs to the body's own defense mechanisms which make it capable of reacting to harmful influences and allow it to stabilize a structure and/or function of the body for a certain period. Here we see a connecting link to the historically grounded term self-healing forces, which has challenged medical doctors in the different historical periods of medical science. They tried to explain these effects based on the current model of the organism. Their understanding of this phenomenon played a role in defining the concept of health and disease. Thus, it seems very fitting to look back into history, since the phenomena discussed here as well as the insights into autoprotective mechanisms will continue to influence medical understanding of health and disease.
authors.affiliation: Abteilung Medizingeschichte, Ethik und Theoriebildung in der Medizin, Medizinische Hochschule Hannover, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Lohff
authors.forename: J
authors.initials: J
authors.lastname: Schaefer
authors.forename: K H
authors.initials: KH
authors.lastname: Nierhaus
authors.forename: T
authors.initials: T
authors.lastname: Peters
authors.forename: T
authors.initials: T
authors.lastname: Schaefer
authors.forename: R
authors.initials: R
authors.lastname: Vos
mesh_terms: D000818:Animals; D004194:Disease; D005826:Genetics, Medical; D006262:Health; D006360:Heat-Shock Proteins / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D018832:Molecular Chaperones / Q000502:physiology*; D009324:Naturopathy; D015398:Signal Transduction
chemical_list: D006360:Heat-Shock Proteins; D018832:Molecular Chaperones