title: Sequence specificity of DNA cleavage by bisnetropsin-linked hydroxamic acid-metal complexes: highly specific cleavage by ferrous complexes.
abstract: Bisnetropsin-linked hydroxamic acids (BNHA) were shown to cleave DNA stands at a single residue with a preferred binding orientation in the presence of ferrous ion. In contrast, the corresponding cerium (III) complexes cleaved DNA with low sequence specificity.
authors.affiliation: Department of Biological Science and Technology, Science University of Tokyo, Noda, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Hashimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
mesh_terms: D001483:Base Sequence; D004269:DNA, Bacterial / Q000737:chemistry / Q000187:drug effects*; D005296:Ferrous Compounds / Q000737:chemistry / Q000494:pharmacology*; D006868:Hydrolysis; D006877:Hydroxamic Acids / Q000737:chemistry / Q000494:pharmacology*; D009429:Netropsin / Q000737:chemistry / Q000494:pharmacology*; D010957:Plasmids
chemical_list: D004269:DNA, Bacterial; D005296:Ferrous Compounds; D006877:Hydroxamic Acids; D009429:Netropsin