title: Toxoplasma gondii antibody in pregnant women with and without HIV infection.
abstract: One thousand two hundred pregnant women were examined for Toxoplasma gondii antibody with the objective of identifying the prevalence and risk factors of the disease. By using Sabin-Feldman Dye test, the prevalence of IgG to Toxoplasma gondii was 13.2%. In this study 19 cases (1.6%) were anti-HIV seropositive. Between HIV-seropositive and HIV-seronegative pregnant women, antibody rates to T. gondii were 21.1% and 13.1% respectively, however, the statistical comparison could not be done due to the very few subjects in the former group (n=4). Concerning the risk factors, among those who had no cat in their house, the prevalence of T. gondii antibody were significantly different between under-cooked and properly-cooked meat consumers (19.5%; and 9.6%; odds ratio=2.28, 95% confidence interval). And when under-cooked meat consumers were excluded, the antibody to T. gondii between two groups (having and not-having cat in the house) were also found the significantly different (31.8% and 19.3%; odd ratio=1.96, 95% confidence interval). In conclusion, consuming under-cooked meat and having a cat in the house, both are risk factors of transmission of toxoplasmosis. Further study with more subjects in HIV-infected pregnant women who had antibody to T. gondii, will be helpful for confirmation of the difference with respect to the non HIV-infected group.
authors.affiliation: Department of Protozoology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
authors.forename: T
authors.initials: T
authors.lastname: Chintana
authors.forename: Y
authors.initials: Y
authors.lastname: Sukthana
authors.forename: B
authors.initials: B
authors.lastname: Bunyakai
authors.forename: A
authors.initials: A
authors.lastname: Lekkla
mesh_terms: D000328:Adult; D017677:Age Distribution; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood*; D002415:Cats; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008460:Meat; D016017:Odds Ratio; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D015597:Pregnancy Complications, Parasitic / Q000453:epidemiology / Q000276:immunology*; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D013785:Thailand / Q000453:epidemiology; D014122:Toxoplasma / Q000276:immunology*; D014123:Toxoplasmosis / Q000453:epidemiology / Q000276:immunology*
chemical_list: D000913:Antibodies, Protozoan