Antibodies prepared to neuronal glutamate receptor subunit3 bind IFNalpha-receptors: implications for an autoimmune process.
Anti-glutamate receptor (GluR) agonist-like antibodies prepared in rabbits that are similar to autoantibodies found in Rasmussen's encephalitis (RE) were found to exhibit greater immunoreactivity towards human interferon alpha receptor (IFNAR-1) than to GluR3. Since antibodies prepared to a defined region of GluR3 can react preferentially to an unrelated sequence in the human IFNAR-1, we propose that the IFNAR-1 may be an heteroclitic antigen of GluR3. These results suggest that differential reactivity toward heteroclitic antigens may contribute to variable clinical characteristics of certain autoimmune diseases.
Gahring
L C
LC
Salt Lake City Veteran's Administration Geriatrics Research, Education and Clinical Center (GRECC) and University of Utah School of Medicine, Salt Lake City 84112, USA.
Carlson
N G
NG
Rogers
S W
SW
D000595:Amino Acid Sequence; D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D015551:Autoimmunity / Q000276:immunology; D002417:Cattle; D004660:Encephalitis / Q000097:blood / Q000276:immunology; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D009474:Neurons / Q000276:immunology*; D011817:Rabbits; D053633:Receptor, Interferon alpha-beta; D017470:Receptors, Glutamate / Q000276:immunology*; D017471:Receptors, Interferon / Q000235:genetics / Q000276:immunology*
D001323:Autoantibodies; D017470:Receptors, Glutamate; D017471:Receptors, Interferon; D053633:Receptor, Interferon alpha-beta