title: Fever as presenting symptom of multiple myeloma.
abstract: We describe a 68-year-old patient presenting with recurrent fever, who eventually turned out to suffer from multiple myeloma. He was treated with Vincristine, Doxorubicin and Dexamethasone combination chemotherapy and intermediate dose Melphalan (70 mg/m2), respectively. Apart from periods of fever due to sepsis following chemotherapy, the recurrent fever disappeared after response, but recurred synchronously with progression of the disease. Recurrent fever in this case should be considered as a symptom of active multiple myeloma. This form of presentation of multiple myeloma has been described in literature only a few times.
authors.affiliation: Department of Internal Medicine, Diakonessenhuis Utrecht, The Netherlands.
authors.forename: C C
authors.initials: CC
authors.lastname: Pitz
authors.forename: H M
authors.initials: HM
authors.lastname: Lokhorst
authors.forename: J B
authors.initials: JB
authors.lastname: Hoekstra
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003907:Dexamethasone / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004317:Doxorubicin / Q000627:therapeutic use; D005334:Fever / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009101:Multiple Myeloma / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D012008:Recurrence; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D003907:Dexamethasone; D004317:Doxorubicin