title: Hyalinizing trabecular adenoma of the thyroid gland: recognition and characterization of its cytoplasmic yellow body.
abstract: Many round, pale yellow, cytoplasmic inclusion bodies were found in hematoxylin and eosin-stained sections of a hyalinizing trabecular adenoma of the thyroid. The bodies were refractile and frequently had a microvacuolated or granular substructure. They were usually located close to the nucleus, often indented it, and rarely occurred within it. Histochemically, they showed a glycosaminoglycan, proteoglycan, and lipid content, displayed autofluorescence on exposure to ultraviolet light, and were unreactive with a variety of immunostains. Ultrastructurally, the inclusions were consistent with giant lysosomes, showing parallel whorled and arrayed membranes ("fingerprint" bodies) as a component of their substructure. Review of sections of 75 hyalinizing trabecular adenomas in our files revealed that the cytoplasmic bodies were present in all cases (100%), indicating that these inclusions most likely are a universal feature of the neoplasm.
authors.affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.
authors.forename: H J
authors.initials: HJ
authors.lastname: Rothenberg
authors.forename: J R
authors.initials: JR
authors.lastname: Goellner
authors.forename: J A
authors.initials: JA
authors.lastname: Carney
mesh_terms: D000236:Adenoma / Q000378:metabolism / Q000473:pathology*; D000328:Adult; D001707:Biopsy, Needle; D004396:Coloring Agents; D005260:Female; D006801:Humans; D006818:Hyalin / Q000378:metabolism; D007124:Immunoenzyme Techniques; D002479:Inclusion Bodies / Q000378:metabolism / Q000473:pathology*; D008062:Lipofuscin / Q000378:metabolism; D015388:Organelles / Q000648:ultrastructure; D013194:Staining and Labeling; D013964:Thyroid Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D004396:Coloring Agents; D008062:Lipofuscin