[Study of combined chronic effects of gamma radiation and lead on the occurrence and repair of DNA injury in mice].
It has been shown that neither exposure of mice to lead in the drinking water (20 mg/l) for 50 days nor chronic gamma-irradiation of animals (1.5 Gy, 1.3 mGy/h, 50 days) induces single-stranded DNA breaks in thymocytes. Acute gamma-irradiation (1 and 4 Gy) of lead-pretreated mice resulted in an inhibiting of repair of radiation-degraded DNA in thymocytes and in an increasing of the level of DNA lesions detected in erythroblasts of bone marrow by the micronuclear test method. Inhibition of ssDNA break repair in thymocytes caused by lead was not seen upon exposure of mice to combined chronic action of gamma-irradiation and lead. Chronic irradiation did not affect the micronuclei rate increase revealing after acute irradiation of lead-treated mice.
Chernikov
A V
AV
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino.
Fomenko
L A
LA
Revina
G I
GI
Medvedev
A I
AI
D000367:Age Factors; D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects / Q000528:radiation effects; D002478:Cells, Cultured; D004247:DNA / Q000187:drug effects* / Q000528:radiation effects*; D004249:DNA Damage; D004260:DNA Repair / Q000187:drug effects* / Q000528:radiation effects*; D004277:DNA, Single-Stranded; D005720:Gamma Rays; D007854:Lead / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D011829:Radiation Dosage; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects; D013997:Time Factors; D014881:Water Supply
D004277:DNA, Single-Stranded; D007854:Lead; D004247:DNA