L-cone pigment genes expressed in normal colour vision.
To directly test the hypothesis that only two pigment genes are expressed from the X-chromosome array, we examined expressed M and L pigment gene sequences from > 100 male eye donors. In this sample, there were eight men who expressed high levels of more than one L pigment gene in addition to M pigment genes. The fact that these eyes expressed both L and M pigment genes at significant levels suggests they were from men with normal colour vision. We reject the hypothesis that only two pigment genes from one X-chromosome array can be expressed.
Sjoberg
S A
SA
Department of Cellular Biology and Anatomy, Medical College of Wisconsin, Milwaukee 53226-0509, USA.
Neitz
M
M
Balding
S D
SD
Neitz
J
J
D000595:Amino Acid Sequence; D001483:Base Sequence; D002874:Chromosome Mapping; D003118:Color Perception / Q000502:physiology*; D018076:DNA, Complementary / Q000032:analysis; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D017949:Retinal Cone Photoreceptor Cells / Q000502:physiology*; D012168:Retinal Pigments / Q000235:genetics*; D014960:X Chromosome
D018076:DNA, Complementary; D012168:Retinal Pigments