title: Changes in postprandial lipoproteins of low and high density caused by moderate alcohol consumption with dinner.
abstract: We measured the effects of consumption of moderate amounts of beer, wine or spirits with evening dinner on plasma LDL and HDL levels as well as composition in 11 healthy middle-aged men. Forty grams of alcohol were consumed daily with dinner for a period of 3 weeks. Mineral water was used as a negative control. Dinner was served at 6 pm and blood samples were obtained at 1 h before and 3, 5, 9, and 13 h after the start of the meal. No differences were detected between the effects of the different alcohol-containing beverages. Plasma levels of triglycerides (TG), measured 1 h before dinner were very variable and higher than fasting values (means of 2.2 and 1.5 mM, respectively). Daily consumption of 40 g of alcohol with dinner resulted in increased postprandial plasma TG levels and decreased low density lipoprotein (LDL) cholesterol concentrations. These effects were transient and observed at 11 pm (TG) and 9 pm and 11 pm (LDL). In contrast, high density lipoproteins (HDL) were raised by alcohol intake at all time points analysed. HDL composition was changed by alcohol consumption, resulting in a raised HDL-cholesterol/apo A-I ratio at 5 pm and 9 pm. The observed alcohol-dependent effects on plasma HDL and LDL during the postprandial phase are considered anti-atherogenic and may contribute to the observed protection against coronary heart disease by moderate alcohol consumption.
authors.affiliation: Department of Biochemistry, Cardiovascular Research Institute COEUR, Faculty of Medicine and Health Sciences, Erasmus University Rotterdam, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: van Tol
authors.forename: M S
authors.initials: MS
authors.lastname: van der Gaag
authors.forename: L M
authors.initials: LM
authors.lastname: Scheek
authors.forename: T
authors.initials: T
authors.lastname: van Gent
authors.forename: H F
authors.initials: HF
authors.lastname: Hendriks
mesh_terms: D000328:Adult; D000428:Alcohol Drinking; D001161:Arteriosclerosis / Q000517:prevention & control; D000431:Ethanol / Q000494:pharmacology; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period
chemical_list: D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D000431:Ethanol