title: Rat Chromosome 2: assignment of the genes encoding cyclin B1, interleukin 6 signal transducer, and proprotein convertase 1 to the Mcs1-containing region and identification of new microsatellite markers.
abstract: The rat Chromosome (Chr) 2 harbors several genes controlling tumor growth or development, blood pressure, and non-insulin-dependent diabetes mellitus. We report that the region (2q1) containing the mammary susceptibility cancer gene Mcs1 also harbors the genes encoding cyclin B1, interleukin 6 signal transducer (gp130), and proprotein convertase 1. We also generated 13 new anonymous microsatellite markers from Chr 2-sorted DNA. These markers, as well as a microsatellite marker in the cyclin B1 gene, were genetically mapped in combination with known markers. A cyclin B1-related gene was also cytogenetically assigned to rat Chr 11q22-q23.
authors.affiliation: Département de Biologie Moléculaire, Université Libre de Bruxelles, Rue des Chevaux, 67; B-1640 Rhode-Saint-Genèse, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Szpirer
authors.forename: F
authors.initials: F
authors.lastname: Tissir
authors.forename: M
authors.initials: M
authors.lastname: Rivière
authors.forename: P
authors.initials: P
authors.lastname: Van Vooren
authors.forename: J
authors.initials: J
authors.lastname: Kela
authors.forename: F
authors.initials: F
authors.lastname: Lallemand
authors.forename: P
authors.initials: P
authors.lastname: Gabant
authors.forename: B
authors.initials: B
authors.lastname: Hoebee
authors.forename: K
authors.initials: K
authors.lastname: Klinga-Levan
authors.forename: G
authors.initials: G
authors.lastname: Levan
authors.forename: J
authors.initials: J
authors.lastname: Szpirer
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000235:genetics*; D002874:Chromosome Mapping; D019926:Cyclin B / Q000235:genetics*; D056744:Cyclin B1; D050822:Cytokine Receptor gp130; D008040:Genetic Linkage; D017404:In Situ Hybridization, Fluorescence; D008562:Membrane Glycoproteins / Q000235:genetics*; D018895:Microsatellite Repeats; D043484:Proprotein Convertases; D051381:Rats; D029701:Saccharomyces cerevisiae Proteins; D013381:Subtilisins / Q000235:genetics*
chemical_list: D015703:Antigens, CD; C534701:Ccnb1 protein, rat; D019926:Cyclin B; D056744:Cyclin B1; C494201:Il6st protein, rat; D008562:Membrane Glycoproteins; D029701:Saccharomyces cerevisiae Proteins; D050822:Cytokine Receptor gp130; D043484:Proprotein Convertases; D013381:Subtilisins; C058751:KEX2 protein, S cerevisiae