[A clinical study of respiratory infection isolating non-pathogenic Neisseria by transtracheal aspiration].
Neisseria species other than N. meningitidis and N. gonorrhoeae are generally regarded as commensal bacterial flora of the oropharynx, and little is known regarding cases of these non-pathogenic Neisseria species in the lower respiratory tract. We clinically examined respiratory tract infections from which non-pathogenic Neisseria species were isolated by transtracheal aspiration (TTA). The incidence of non-pathogenic Neisseria isolated was 54 (15.7%) out of 344 episodes of respiratory tract infections with isolated microorganisms from TTA, and was 17.6%, 15.8%, 14.3% for pneumonia, acute bronchitis, and chronic lower respiratory tract infection, respectively. All 54 episodes were isolated with other microorganisms such as alpha-Streptococcus spp. (75.9%), Haemophilus influenzae (25.9%) and anaerobics (22.2%). The isolation ratio according to the age group increased at 45 years of age or more, but did not increase with the advance of age. Predisposing factors were identified such as overt aspiration, iatrogenic procedure and heavy smoking. Cases without overt aspiration that had fevers of 38 degrees C or more or hypoxemia of less than PaO2 70 torr when detecting non-pathogenic Neisseria were observed more frequently in the aged than the non-aged. The findings suggest the detection of non-pathogenic Neisseria by TTA is influenced by the host state that the fall of microorganisms from the upper to lower respiratory tract cannot be defended or excluded by mucociliary transportation disorder due to underlying disease and smoking, or deterioration of physical status other than overt or silent aspiration.
Maeda
K
K
Second Department of Internal Medicine, Nara Medical University.
Konishi
M
M
Mikasa
K
K
Majima
T
T
Ueda
K
K
Yoshimoto
E
E
Sakamoto
M
M
Hamada
K
K
Sawaki
M
M
Sano
R
R
Masutani
T
T
Narita
N
N
D000367:Age Factors; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009079:Mucociliary Clearance; D009343:Neisseria / Q000302:isolation & purification*; D011015:Pneumonia, Aspiration; D012137:Respiratory System / Q000382:microbiology / Q000503:physiopathology; D012141:Respiratory Tract Infections / Q000382:microbiology*; D012907:Smoking / Q000009:adverse effects