[Exacerbation of tics by prednisolone].
Tics-disorders are hyperkinetic movement disorders which manifest in childhood or early adolescence and ameliorate in later adulthood. We report on two patients with a basically subclinical tic-disorder (age of 53 and 68 years). During the therapy of polymyalgia rheumatica and endocrine orbitopathy in Graves disease with prednisolone the tics exacerbated and were therefore diagnosed and treated for the first time. Possible causes for the exacerbation of the tics during the therapy with glucocorticosteroids are discussed in the context of the dopamine hypothesis of tics.
Dietl
T
T
Max-P anck-Institut für Psychiatrie, München.
Kümpfel
T
T
Hinze-Selch
D
D
Trenkwalder
C
C
Lechner
C
C
D000368:Aged; D017109:Akathisia, Drug-Induced / Q000175:diagnosis; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006111:Graves Disease / Q000188:drug therapy*; D006801:Humans; D008875:Middle Aged; D011111:Polymyalgia Rheumatica / Q000188:drug therapy*; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects*; D013981:Tic Disorders / Q000139:chemically induced* / Q000175:diagnosis; D005879:Tourette Syndrome / Q000139:chemically induced* / Q000175:diagnosis
D000893:Anti-Inflammatory Agents; D011239:Prednisolone