Linkage disequilibrium mapping of complex disease: fantasy or reality?
In the past year, data about the level and nature of linkage disequilibrium between alleles of tightly linked SNPs have started to become available. Furthermore, increasing evidence of allelic heterogeneity at the loci predisposing to complex disease has been observed, which has lead to initial attempts to develop methods of linkage disequilibrium detection allowing for this difficulty. It has also become more obvious that we will need to think carefully about the types of populations we need to analyze in an attempt to identify these elusive genes, and it is becoming clear that we need to carefully re-evaluate the prognosis of the current paradigm with regard to its robustness to the types of problems that are likely to exist.
Terwilliger
J D
JD
Columbia University Department of Psychiatry Columbia and Genome Center 60, Haven Avenue #15-C New York NY 10032 USA. joseph. terwilliger@columbia.edu.
Weiss
K M
KM
D002874:Chromosome Mapping; D030342:Genetic Diseases, Inborn / Q000453:epidemiology / Q000235:genetics*; D005819:Genetic Markers; D005828:Genetics, Population; D006801:Humans; D015810:Linkage Disequilibrium; D008957:Models, Genetic
D005819:Genetic Markers