Opposite effects of angiotensin II and IV in the lateral nucleus of the amygdala.
In this study the effects of angiotensin II and norleucine1-angiotensin IV have been studied in a horizontal in vitro slice preparation of female rat brains. Extracellular field potentials of the lateral nucleus of the basolateral amygdala were recorded. The results show that angiotensin II significantly increased the amplitude of field potentials induced by the electrical stimulation of the lateral nucleus, whereas norleucine1-angiotensin IV caused a significant decrease in the amplitude of field potentials. The angiotensin-induced effects could be blocked by specific angiotensin receptor antagonists. These opposite effects of angiotensin II and IV on electrophysiological parameters are in agreement with behavioral studies that have demonstrated that angiotensin II and IV produce opposite effects on the retention of an inhibitory shock-avoidance response and correlate with their different effects on the blood vessels.
von Bohlen und Halbach
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Institute of Physiology, Faculty of Medicine (Charité), Humboldt University, Berlin, Germany. oliver.von_bohlen@charite.de
Albrecht
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D000679:Amygdala / Q000187:drug effects*; D000804:Angiotensin II / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000818:Animals; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D066298:In Vitro Techniques; D051381:Rats; D017208:Rats, Wistar
D000804:Angiotensin II; C012877:angiotensin II, des-Asp(1)-des-Arg(2)-Ile(5)-