Role of the systemic inflammatory response syndrome in the development of protein-calorie malnutrition in ESRD.
Chronic activation of the systemic inflammatory response is a common and unifying factor in many end-stage illnesses, particularly end-stage renal disease. Protein-calorie malnutrition and hypoalbuminemia, which are prominent features of end-stage renal disease, develop as a consequence of this syndrome. Recognition of this relationship can assist in the development of new approaches to the successful management of protein-calorie malnutrition developing in the course of end-stage renal disease.
Bistrian
B R
BR
Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. bbistria@west.bidmc.harvard.edu
D016207:Cytokines / Q000502:physiology; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology; D007676:Kidney Failure, Chronic / Q000150:complications*; D011502:Protein-Energy Malnutrition / Q000209:etiology* / Q000503:physiopathology; D012709:Serum Albumin / Q000172:deficiency; D018746:Systemic Inflammatory Response Syndrome / Q000150:complications* / Q000503:physiopathology
D016207:Cytokines; D018836:Inflammation Mediators; D012709:Serum Albumin