title: Toxicity and allergy to local anesthesia.
abstract: Considering the amount of local anesthetic administered on a daily basis, dental professionals must be familiar with the factors that influence the dose and type of local anesthetic that induces a toxic or allergic reaction. In addition to the route and rate of administration, the patient's physical condition and health may also influence the dose of local anesthetic that could be safely administered. This article reviews the different causes of local anesthesia toxicity and allergy. With prevention and early recognition of the warning signs, poor prognosis can be avoided.
authors.affiliation: University of Southern California School of Dentistry, Department of Anesthesiology and Medicine, USA.
authors.forename: A H
authors.initials: AH
authors.lastname: Chen
mesh_terms: D000367:Age Factors; D000707:Anaphylaxis / Q000175:diagnosis; D000766:Anesthesia, Dental / Q000009:adverse effects*; D000779:Anesthetics, Local / Q000009:adverse effects*; D002319:Cardiovascular System / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects; D002648:Child; D004305:Dose-Response Relationship, Drug; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D011247:Pregnancy
chemical_list: D000779:Anesthetics, Local