Mitochondrial dynamics in yeast.
Proteins that control mitochondrial dynamics in yeast are being identified at a rapid pace. These proteins include cytoskeletal elements that regulate organelle distribution and inheritance and several outer membrane proteins that are required to maintain the branched, mitochondrial reticulum. Interestingly, three of the high molecular weight GTPases encoded by the yeast genome are required for mitochondrial integrity and are potential regulators of mitochondrial branching, distribution, and membrane fusion. The recent finding that mtDNA mixing is restricted in the mitochondrial matrix has stimulated the hunt for the molecular machinery that anchors mitochondrial nucleoids in the organelle. Considering that many aspects of mitochondrial structure and behavior are strikingly similar in different cell types, the functional analyses of these yeast proteins should provide general insights into the mechanisms governing mitochondrial dynamics in all eukaryotes.
Hermann
G J
GJ
Department of Biology, University of Utah, Salt Lake City 84112, USA.
Shaw
J M
JM
D002453:Cell Cycle; D002467:Cell Nucleus / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology; D004271:DNA, Fungal / Q000235:genetics / Q000378:metabolism; D004272:DNA, Mitochondrial / Q000235:genetics / Q000378:metabolism; D020558:GTP Phosphohydrolases / Q000235:genetics / Q000378:metabolism; D016681:Genome, Fungal; D007425:Intracellular Membranes / Q000502:physiology; D008561:Membrane Fusion; D008928:Mitochondria / Q000235:genetics / Q000502:physiology* / Q000648:ultrastructure; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000502:physiology* / Q000648:ultrastructure
D004271:DNA, Fungal; D004272:DNA, Mitochondrial; D020558:GTP Phosphohydrolases