title: [Severe Legionella micdadei pneumonia effectively treated with hemofiltration therapy].
abstract: A 42-year-old man was admitted because of fever, productive cough, and progressive dyspnea. Chest x-ray films and computed tomographic scans disclosed dense consolidation in the left and right lung fields. No pathogenic agent was found despite extensive bacteriological examinations. Based on serological findings, the patient was given a diagnosis of acute pneumonia caused by Legionella micdadei. It has been reported that Legionnaire's disease is easily complicated by fatal systemic illnesses such as disseminated intravascular coagulation (DIC) and multiple organ failure. In fact, the patient suffered from severe hypotension and DIC on admission. Treatments against systemic complications were started together with intravenous administration of antibiotics including erythromycin. Continuous intravenous cathecolamin, however, failed to alleviate the patient's shock. We therefore applied endotoxin eliminating therapy using a polymyxin-B-column (PMX) and continuous hemofiltration (CHF). The patient recovered from critical shock immediately after the start of PMX, which together with CHF, alleviated his systemic complications. Although the factors responsible for fatal systemic complications in Legionnare's disease are not well-documented, our findings suggested that some substances removable by PMX and CHF play an important role in pathogenesis.
authors.affiliation: Department of Medicine, Saga Medical School, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Matsubara
authors.forename: S
authors.initials: S
authors.lastname: Akashi
authors.forename: K
authors.initials: K
authors.lastname: Naitoh
authors.forename: Y
authors.initials: Y
authors.lastname: Nakahara
authors.forename: S
authors.initials: S
authors.lastname: Hayashi
mesh_terms: D004359:Drug Therapy, Combination / Q000008:administration & dosage; D004917:Erythromycin / Q000008:administration & dosage; D006440:Hemofiltration / Q000379:methods; D006801:Humans; D007875:Legionella / Q000302:isolation & purification*; D007876:Legionellosis; D008297:Male; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000382:microbiology / Q000628:therapy*; D011112:Polymyxin B / Q000008:administration & dosage
chemical_list: D004917:Erythromycin; D011112:Polymyxin B