[Importance of realistic tests for drug allergy: apropos of a clinical case].
Drug allergy is the most difficult area in Allergology because: Clinical polymorphism and specially physiopathology (IgE-dependent hypersensibility reaction, cyclo-oxygenase inhibitor, etc.). Feeble specificity and sensitivity in the basic immunoallergic investigation (Skin tests, specific IgE). Very frequently his necessitates recourse to REALISTIC TESTS of drug re-introduction under clinical and biological surveillance (HSI mediators: histamine/tryptase/urinary methyl histamine) to produce a diagnosis.
Hassoun
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Laboratoire d'Immuno-Allergologie-CHU, Angers.
D000328:Adult; D000485:Allergens / Q000009:adverse effects* / Q000276:immunology; D000658:Amoxicillin / Q000009:adverse effects* / Q000276:immunology; D000707:Anaphylaxis / Q000139:chemically induced*; D015549:Basophil Degranulation Test; D053818:Chymases; D019818:Clavulanic Acid; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000209:etiology; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D008761:Methylhistamines / Q000652:urine; D010038:Otorhinolaryngologic Diseases / Q000188:drug therapy; D012697:Serine Endopeptidases / Q000097:blood; D012882:Skin Tests; D053802:Tryptases; D014839:Vomiting / Q000139:chemically induced
D000485:Allergens; D008761:Methylhistamines; D019818:Clavulanic Acid; D007073:Immunoglobulin E; C031205:3-methylhistamine; D000658:Amoxicillin; D012697:Serine Endopeptidases; C083294:chymase 2; D053818:Chymases; D053802:Tryptases