title: [Factors related with compliance with tuberculosis chemoprophylaxis].
abstract: OBJECTIVE
  To determine therapeutic tolerance and compliance level with antituberculous chemoprophylaxis.
  
  
  METHODS
  587 patients were proposed for antituberculous chemoprophylaxis with isoniazid from January 1995 to June 1996 in Murcia (Spain).
  
  
  RESULTS
  3.6% of the patients gave up treatment because of hepatic intolerance and 73% completed the prophylaxis. Non-compliance related factors were: social risk factors (odds ratio [OR] = 9.31), previous history of allergies (OR = 2.87), previous personal history of tuberculosis-related events (OR = 0.49) and interaction between sex and age.
  
  
  CONCLUSIONS
  Support and intervention measures directed to risk groups of a social origin deem to be needed. Control measures and information provided to middle-aged males, with particular emphasis to the first weeks of prophylaxis, should also be implemented.
authors.affiliation: Centro de Prevención y Control de la Tuberculosis, Consejería de Sanidad y Política Social de Murcia.
authors.forename: F
authors.initials: F
authors.lastname: Galvañ Olivares
authors.forename: C
authors.initials: C
authors.lastname: Santiuste de Pablos
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000995:Antitubercular Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance / Q000706:statistics & numerical data*; D017678:Sex Distribution; D014376:Tuberculosis / Q000517:prevention & control*
chemical_list: D000995:Antitubercular Agents