title: Impact of irritable bowel syndrome on quality of life and resource use in the United States and United Kingdom.
abstract: BACKGROUND
  Although irritable bowel syndrome (IBS) is not a life-threatening condition, it can have a serious impact on a patient's daily activities and quality of life. This effect on quality of life has not been compared previously across different cultures.
  
  
  METHODS
  We compared measures of health-related quality of life and health care resource utilization using a cross-sectional point-in-time postal survey of a random sample of 500 members of the International Foundation for Functional Gastrointestinal Disorders in the US and 500 members of the IBS Network support group in the UK. The analysis was limited to persons who reported that a physician had told them they had IBS. A general health status questionnaire, the SF-36, and a disease-specific questionnaire, the Irritable Bowel Syndrome Quality of Life questionnaire (IBSQOL), were self-administered as part of the survey to measure health-related quality of life. Results on the SF-36 were compared with published normative data for adults in the US and UK with and without chronic diseases.
  
  
  RESULTS
  The UK group (n = 343) reported significantly poorer quality of life on the SF-36 and on four parameters of the IBSQOL than did the US group (n = 287). The general health status of persons with IBS in either country was much poorer compared with that of general populations in the respective countries. Health care resource utilization (i.e. emergency room, doctor and hospital outpatient visits) of persons with IBS was similar in the two countries, as was the direct effect of IBS on employment. Nearly one third of those surveyed missed at least 1 day of work due to IBS in the previous 4 weeks, and a greater percentage cut back in their work or activities due to IBS. Taken together, average time lost or cut back amounted to nearly 5 days or 1 work-week.
  
  
  CONCLUSIONS
  IBS has a significant impact on quality of life and resource use in both the US and UK. The effect on quality of life, however, appears to be greater in the UK than in the US.
authors.affiliation: Glaxo Wellcome plc, Research Triangle Park, NC 27709-3398, USA.
authors.forename: B A
authors.initials: BA
authors.lastname: Hahn
authors.forename: S
authors.initials: S
authors.lastname: Yan
authors.forename: S
authors.initials: S
authors.lastname: Strassels
mesh_terms: D000041:Absenteeism; D000293:Adolescent; D000328:Adult; D000368:Aged; D003109:Colonic Diseases, Functional / Q000453:epidemiology* / Q000523:psychology; D003430:Cross-Sectional Studies; D004651:Employment / Q000706:statistics & numerical data; D005260:Female; D006295:Health Resources / Q000706:statistics & numerical data*; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012494:Sampling Studies; D011795:Surveys and Questionnaires; D006113:United Kingdom / Q000453:epidemiology; D014481:United States / Q000453:epidemiology