title: Combined heart and kidney transplantation using a single donor: a single center's experience with nine cases.
abstract: BACKGROUND
  Simultaneous double-organ transplants comprising various organ combinations have become frequent. The purpose of this article is to report on a single center's experience of simultaneous heart and kidney transplantation (HNTX) with particular emphasis on selection criteria and patient outcome.
  
  
  METHODS
  From September 1990 to January 1997, nine patients underwent HNTX, receiving both grafts from a single donor selected on ABO blood group compatibility and a negative lymphocytotoxic crossmatch, but without regard to HLA-antigen matching.
  
  
  RESULTS
  One patient died of acute humoral rejection of the cardiac graft shortly after surgery. Eight patients are alive and well and have normal cardiac and renal function at a mean follow-up of 44+/-28 months.
  
  
  CONCLUSIONS
  HNTX offers a compelling therapeutic solution in the treatment of advanced cardiac and renal failure in carefully selected patients. Because the heart and kidney rejection episodes were independent of each other, rejection surveillance should be carried out separately for each transplanted organ.
authors.affiliation: Department of Surgery, University of Vienna, Vienna General Hospital, Austria.
authors.forename: A A
authors.initials: AA
authors.lastname: Kocher
authors.forename: B
authors.initials: B
authors.lastname: Schlechta
authors.forename: C W
authors.initials: CW
authors.lastname: Kopp
authors.forename: M
authors.initials: M
authors.lastname: Ehrlich
authors.forename: J
authors.initials: J
authors.lastname: Ankersmit
authors.forename: P
authors.initials: P
authors.lastname: Ofner
authors.forename: F
authors.initials: F
authors.lastname: Langer
authors.forename: G A
authors.initials: GA
authors.lastname: Berlakovich
authors.forename: M
authors.initials: M
authors.lastname: Grimm
authors.forename: E
authors.initials: E
authors.lastname: Wolner
authors.forename: G
authors.initials: G
authors.lastname: Laufer
mesh_terms: D000328:Adult; D005260:Female; D006084:Graft Rejection; D016027:Heart Transplantation / Q000009:adverse effects / Q000401:mortality; D006650:Histocompatibility Testing; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects / Q000401:mortality; D008297:Male; D008875:Middle Aged; D014019:Tissue Donors