title: Antenatal and perinatal antecedents of moderate and severe spastic cerebral palsy.
abstract: Routinely collected perinatal morbidity data were abstracted for 204 cases of moderate and severe spastic cerebral palsy and 816 matched controls. Separate analyses were conducted for cases with birth-weight > or = 2,500 g and birth-weight < 2,500 g. The presence of a congenital abnormality was an important risk factor for cerebral palsy in both groups and further analyses were conducted after dividing the groups according to presence or absence of a congenital abnormality. In the < 2,500 g group, resuscitation needed was clearly identified as a risk factor for cerebral palsy in the group with no congenital abnormalities (adjusted OR=3.4; 95% CI=1.6-7.5) while in the group with congenital abnormalities, none of the risk factors were clearly associated with an increased risk of cerebral palsy. Among the cases with birth-weight > or = 2,500 g, intrauterine hypoxia/birth asphyxia was clearly associated with an increased risk of cerebral palsy (adjusted OR=18.1; 95% CI=1.8-186) in the group with no congenital abnormalities while in the group with congenital abnormalities, none of the factors were clearly associated with an increased risk of cerebral palsy.
authors.affiliation: Department of Child Development and Rehabilitation, Royal Children's Hospital, Melbourne, Victoria, Australia.
authors.forename: G S
authors.initials: GS
authors.lastname: Dite
authors.forename: R
authors.initials: R
authors.lastname: Bell
authors.forename: D S
authors.initials: DS
authors.lastname: Reddihough
authors.forename: C
authors.initials: C
authors.lastname: Bessell
authors.forename: S
authors.initials: S
authors.lastname: Brennecke
authors.forename: M
authors.initials: M
authors.lastname: Sheedy
mesh_terms: D001238:Asphyxia Neonatorum / Q000453:epidemiology; D016022:Case-Control Studies; D015984:Causality; D002547:Cerebral Palsy / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D012307:Risk Factors