Transient acute myopia induced by antilymphocyte globulins.
Acute onset of transient myopia may be induced by several drugs, different mechanisms having been described. We report the occurrence of such an event after intravenous administration of equine antilymphocyte globulins in a patient treated for aplastic anemia. Clinical ocular examination revealed no other abnormality, and ultrasonography disclosed no swelling of the ciliary body. The drug-induced myopia resolved completely after instillation of topical cyclopentolate, suggesting that its mechanism was the occurrence of a ciliary spasm. Acute myopia is a rare event and, to the authors' knowledge, this represents the first case described as being induced by antilymphocyte globulins.
Milea
D
D
Clinique Ophtalmologique Universitaire, Hôpital Edouard-Herriot, Lyon, France.
Zech
C
C
Dumontet
C
C
Coiffier
B
B
Trepsat
C
C
D000208:Acute Disease; D000328:Adult; D000741:Anemia, Aplastic / Q000628:therapy; D000961:Antilymphocyte Serum / Q000009:adverse effects*; D002924:Ciliary Body / Q000187:drug effects / Q000503:physiopathology; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D009216:Myopia / Q000139:chemically induced* / Q000188:drug therapy; D013035:Spasm / Q000139:chemically induced / Q000188:drug therapy
D000961:Antilymphocyte Serum; D005938:Glucocorticoids; D007166:Immunosuppressive Agents