Inflammatory response to cardiopulmonary bypass using two different types of heparin-coated extracorporeal circuits.
Previous reports have highlighted the disparity in biocompatibility of two differently engineered heparin coatings during the cardiopulmonary bypass (CPB) procedure. The aim of this prospective study was to evaluate the impact of the difference in haemocompatibility provided by either the Duraflo II equipment or the Carmeda equipment in the terminal inflammatory response observed after coronary artery surgery. Thirty patients were randomly allocated to two groups to be operated on using either Duraflo II equipment (group I) or Carmeda equipment (group 2) for extracorporeal circulation (ECC). Initial inflammatory response was assessed by terminal complement complex activation (SC5b-9). The late inflammatory response observed in the postoperative period was assessed by measuring cytokine production (tumour factor necrosis (TNF alpha), interleukin IL-6, interleukin IL-8) and circulating concentrations of adhesion molecules (ELAM-1, ICAM-1). The release of SC5b-9 after CPB and after protamine administration was lower in group 2 than in group 1 (p = 0.0002 and p = 0.006, respectively). A significant production of cytokines was detected in both groups with peak values observed within the time range of 4-6 h after the start of CPB.
Baufreton
C
C
Department of Thoracic and Cardiovascular Surgery, Hôpital Henri Mondor, Créteil. ChBaufreton@chu-angers.fr
Moczar
M
M
Intrator
L
L
Jansen
P G
PG
te Velthuis
H
H
Le Besnerais
P
P
Farcet
J P
JP
Wildevuur
C R
CR
Loisance
D Y
DY
D000368:Aged; D000925:Anticoagulants / Q000494:pharmacology*; D002315:Cardiopulmonary Bypass / Q000009:adverse effects / Q000295:instrumentation*; D003167:Complement Activation; D016207:Cytokines / Q000096:biosynthesis; D019040:E-Selectin / Q000097:blood; D005260:Female; D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D007249:Inflammation / Q000209:etiology*; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
D000925:Anticoagulants; D016207:Cytokines; D019040:E-Selectin; D018799:Intercellular Adhesion Molecule-1; D006493:Heparin