title: Sequential construction of multiple-objective optimal designs.
abstract: We propose a sequential approach for constructing multiple-objective locally optimal designs for nonlinear models. The technique used here is a general one and we demonstrate the added benefits of using a multiple-objective design over a single-objective design with examples from biomedical studies.
authors.affiliation: University of California at Los Angeles 90095, USA.
authors.forename: Y C
authors.initials: YC
authors.lastname: Huang
authors.forename: W K
authors.initials: WK
authors.lastname: Wong
mesh_terms: D001699:Biometry / Q000379:methods*; D015233:Models, Statistical; D017711:Nonlinear Dynamics