Immune-mediated peripheral neuropathies and voltage-gated sodiums channels.
Antibodies to GM1 ganglioside are found in some patients with the Guillain-Barré syndrome and multifocal motor neuropathy, and may alter neuronal excitability. We measured voltage-gated sodium channel (VGSC) function by 22Na+ influx in a motor neuronal cell line (NSC19) in which we demonstrated GM1 ganglioside and tetrodotoxin-sensitive VGSC function. We were unable to detect any effect of peripheral neuropathy plasmas, with or without complement, on VGSC function in NSC19 cells.
Benatar
M
M
Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom.
Willison
H J
HJ
Vincent
A
A
D000818:Animals; D001323:Autoantibodies / Q000494:pharmacology; D002460:Cell Line; D005455:Fluorescent Antibody Technique; D005677:G(M1) Ganglioside / Q000378:metabolism; D006801:Humans; D051379:Mice; D019846:Miller Fisher Syndrome / Q000276:immunology; D009046:Motor Neurons / Q000187:drug effects / Q000378:metabolism*; D009157:Myasthenia Gravis / Q000276:immunology; D010523:Peripheral Nervous System Diseases / Q000276:immunology; D011129:Polyradiculoneuropathy / Q000276:immunology; D012964:Sodium / Q000378:metabolism; D015222:Sodium Channels / Q000187:drug effects / Q000378:metabolism*
D001323:Autoantibodies; D015222:Sodium Channels; D005677:G(M1) Ganglioside; D012964:Sodium