[Do flame retardants increase the risk of non-Hodgkin lymphoma? The levels of polybrominated diphenyl ethers are increasing in the environment].
Adipose tissue levels of tetra-BDE (2,2',4,4' tetra-brominated diphenyl ether) were measured in 42 male or female cancer patients [19 with non-Hodgkin's lymphoma (NHL), 23 with malignant melanoma (MM)], and in 27 controls without a diagnosis of cancer. As compared with tetra-BDE concentrations in controls, those in the MM subgroup did not differ, but those in the NHL subgroup were higher. Subgrouping of the cancer patients by occupational categories showed professional car, bus and truck drivers (at possible risk of exposure to PBDEs used as flame retardants in vehicle manufacture) to have higher tetra-BDE levels than controls, but not computer operators (at possible risk of exposure to PBDEs used in VDUs). Due to the small size of the series, however, the results may solely be regarded as hypothesis-generating, and further studies are needed.
Hardell
L
L
Onkologiska kliniken, Regionsjukhuset, Orebro.
Lindström
G
G
van Bavel
B
B
Wingfors
H
H
Sundelin
E
E
Liljegren
G
G
Lindholm
P
P
D000328:Adult; D000368:Aged; D005260:Female; D005411:Flame Retardants / Q000009:adverse effects* / Q000032:analysis; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects; D011075:Polybrominated Biphenyls / Q000009:adverse effects* / Q000032:analysis; D012307:Risk Factors
D005411:Flame Retardants; D011075:Polybrominated Biphenyls