[The biochemical marker dynamics of the maternal serum in different chromosomal disorders of the fetus].
The reasons for false-positive results of Down syndrome screening have been analysed. It has been found that the family pericentric inversions of chromosome 9 in fetus are accompanied by AFP and HCG changes equal to Down syndrome pregnancies. The average marker's levels in cases of per inv (9) were: AFp-0.51 MoM, HCG-3.71 MoM. The dynamics of markers in amniotic fluid has been studied. Clinical significance of per inv (9) in medicogenetic consultation were discussed.
Arbuzova
S B
SB
Nikolenko
M I
MI
Khlevnaia
L A
LA
Fedotova
O O
OO
Solov'eva
V D
VD
Malova
S A
SA
Krasnov
A V
AV
D000653:Amniotic Fluid / Q000737:chemistry; D015415:Biomarkers / Q000097:blood; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000032:analysis; D002869:Chromosome Aberrations / Q000097:blood* / Q000235:genetics; D025063:Chromosome Disorders; D007446:Chromosome Inversion; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics; D005260:Female; D006801:Humans; D007621:Karyotyping; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D014455:Ukraine; D000509:alpha-Fetoproteins / Q000032:analysis
D015415:Biomarkers; D018997:Chorionic Gonadotropin, beta Subunit, Human; D000509:alpha-Fetoproteins