title: Structure-activity relationship homology (SARAH): a conceptual framework for drug discovery in the genomic era.
abstract: Extension of the traditional pharmacological approach of protein target classification to whole target systems has the potential to relate elements of protein sequence to the structure-activity relationship (SAR) of small molecules that can modulate protein action. Grouping potential drug discovery targets into families based on the relatedness of their SAR provides a means to translate the information from genome-sequencing efforts into knowledge that will aid in the discovery of drugs.
authors.affiliation: Division of Chemistry Glaxo Wellcome Inc., 3.4134 5 Moore Drive Research Triangle Park NC 27709 USA. svf3511@glaxowellcome.com
authors.forename: S V
authors.initials: SV
authors.lastname: Frye
mesh_terms: D002626:Chemistry, Pharmaceutical; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D011494:Protein Kinases / Q000737:chemistry; D011506:Proteins / Q000737:chemistry* / Q000145:classification; D017386:Sequence Homology, Amino Acid; D013329:Structure-Activity Relationship
chemical_list: D011506:Proteins; D011494:Protein Kinases