Salivary defence factor concentrations in relation to oral and general parameters in HIV positive patients.
The objective of this study was to determine the relationships between saliva protein concentrations, oral mucosal lesions, and systemic parameters in HIV positive patients and controls. Twenty-three control volunteers and 58 HIV-antibody positive patients received a complete oral examination and medical evaluation. In saliva and serum samples, protein concentrations were recorded by a nephelometric method. The systemic parameters assessed were CD4+ cell count, CDC stages and antiretroviral therapy. Oral mucosal lesion prevalence was higher among subjects with lower CD4+ counts. Considering the protein profile, correlations were recorded between saliva and serum protein concentration for IgA, haptoglobin and alpha1-proteinase inhibitor. Using assays of immune and non-immune saliva defence factors, we found that the evolution of cellular immuno-suppression during HIV infection was correlated to oral mucosal disease, showing a relationship between local and general systems.
Grimoud
A M
AM
Laboratory for Oro-Facial Biology, Faculty of Dentistry, Toulouse III University and Hôtel Dieu, University Hospital, France. doydenta@adm.ups-tlse.fr
Arnaud
C
C
Dellamonica
P
P
Lodter
J P
JP
D000328:Adult; D000418:Albumins / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis; D018791:CD4 Lymphocyte Count; D002180:Candidiasis, Oral / Q000097:blood / Q000150:complications / Q000276:immunology; D016022:Case-Control Studies; D003176:Complement C3 / Q000032:analysis; D005260:Female; D006679:HIV Seropositivity / Q000097:blood / Q000150:complications / Q000276:immunology*; D006242:Haptoglobins / Q000032:analysis; D006801:Humans; D007111:Immunity, Cellular; D018928:Immunity, Mucosal; D007132:Immunoglobulin Isotypes / Q000032:analysis / Q000097:blood; D017733:Leukoplakia, Hairy / Q000097:blood / Q000150:complications / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology; D009391:Nephelometry and Turbidimetry; D009961:Orosomucoid / Q000032:analysis; D010518:Periodontitis / Q000097:blood / Q000150:complications / Q000276:immunology; D012471:Salivary Proteins and Peptides / Q000032:analysis* / Q000276:immunology*; D018709:Statistics, Nonparametric; D014168:Transferrin / Q000032:analysis; D000515:alpha 1-Antitrypsin / Q000032:analysis; D000511:alpha-Macroglobulins / Q000032:analysis
D000418:Albumins; D001798:Blood Proteins; D003176:Complement C3; D006242:Haptoglobins; D007132:Immunoglobulin Isotypes; D009961:Orosomucoid; D012471:Salivary Proteins and Peptides; D014168:Transferrin; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins