[Role of GABA in the modulation of Na, K-pump activity in nerve cells after irradiation and experimental modification of membrane lipid component].
After irradiation acute (12 Gy, 600 mGy/min), single prolonged (0.25 Gy, 1.75 mG/min), chronic (0.01 Gy/day, 0.25 Gy, 0.50 Gy, 1.75 mGy/min), and experimental disturbances of cell membranes with phospholipases-A2, -D, and arachidonic acid administration the considerable changes in Na,K-pump function were found in rat brain cortex slices, with their reduction almost to the control level in presence of gamma-aminobutyric acid (0.1-10.0 mcM). It had been supposed existing of the GABA-ergic "homeostasis control" mechanism, which restores the intracellular potassium homeostasis via GABA-modulation of the Na,K-pump activity by principles of receptor-mediated structural-membrane regulation under extreme factor influence.
Anan'eva
T V
TV
Research Institute of Biology, Dnipropetrovsk University, Ukraine.
D000818:Animals; D016718:Arachidonic Acid / Q000494:pharmacology; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects*; D003627:Data Interpretation, Statistical; D019583:Dose Fractionation, Radiation; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D006706:Homeostasis; D066298:In Vitro Techniques; D008051:Lipid Bilayers / Q000378:metabolism; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism*; D010739:Phospholipase D / Q000494:pharmacology; D010741:Phospholipases A / Q000494:pharmacology; D011829:Radiation Dosage; D011839:Radiation, Ionizing; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013997:Time Factors; D014916:Whole-Body Irradiation; D005680:gamma-Aminobutyric Acid / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*
D005230:Fatty Acids, Nonesterified; D008051:Lipid Bilayers; D008563:Membrane Lipids; D016718:Arachidonic Acid; D005680:gamma-Aminobutyric Acid; D010741:Phospholipases A; D010739:Phospholipase D; D000254:Sodium-Potassium-Exchanging ATPase