[Possible pathophysiologic, diagnostic and therapeutic implications of new findings on leptin secretion within the scope of anorexia nervosa].
OBJECTIVE
Leptin is a hormone synthesized in adipocytes and secreted into the bloodstream. It plays an important role in the regulation of body weight, the adaptation to semi-starvation and in reproductive function. Hence, clinical studies pertaining to anorexia nervosa can serve to further elucidate the functions of this hormone in light of the unique features of this disorder.


METHODS
Circulating concentrations of leptin are exceedingly low during the acute stage of anorexia nervosa. Which symptoms result from these diminished concentrations must be clarified. Furthermore, research is required to evaluate whether or not a too rapid weight gain might induce a physiological counter-regulation which would predispose to renewed loss of weight.


RESULTS
This review summarizes findings to date pertaining to leptin secretion in patients with anorexia nervosa. In addition, possible diagnostic, pathophysiological and therapeutic implications are discussed.
Wewetzer
C
C
Klinik für Psychiatrie und Psychotherapie des Kindes- und Jugendalters, Universität Würzburg.
Mauer-Mucke
K
K
Ballauff
A
A
Remschmidt
H
H
Hebebrand
J
J
D000273:Adipose Tissue / Q000503:physiopathology; D000293:Adolescent; D000818:Animals; D000856:Anorexia Nervosa / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D001835:Body Weight / Q000502:physiology; D002648:Child; D005260:Female; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D020738:Leptin; D051379:Mice; D008820:Mice, Obese; D011506:Proteins / Q000502:physiology*
D020738:Leptin; D011506:Proteins