title: The discovery and validation of new drug targets in cancer.
abstract: Advances in our understanding of the signal transduction pathways involved in cellular growth control have provided several new strategies for cancer therapy. Recent advances now make it possible to develop selective inhibitors targeting genomic instability, the growth, survival, and invasion of the tumor, and its nourishment through the growth of new blood vessels.
authors.affiliation: SUGEN Inc. 230 East Grand Avenue South San Francisco CA 94080 USA. sara-courteneidge@sugen.com.
authors.forename: S A
authors.initials: SA
authors.lastname: Courtneidge
authors.forename: G D
authors.initials: GD
authors.lastname: Plowman
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D017209:Apoptosis; D002455:Cell Division; D002470:Cell Survival; D015195:Drug Design; D006801:Humans; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000098:blood supply / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D009389:Neovascularization, Pathologic
chemical_list: D000970:Antineoplastic Agents