Prevention of febrile convulsions with dipropylacetate (Depakine).
In 47 children followed for 1 year after the first "simple" febrile convulsion, dipropylacetate (Depakine, 20 mg/kg) was as effective in preventing new febrile convulsions (a single recurrence in 4% of 47 children) as was phenobarbital (5 mg/kg) or primidone (25 mg/kg) (a single recurrence in 4% of 47 children), and there were no side effects. Of 47 untreated children followed for 1 year, 55% had 1 to 4 new febrile convulsions. All medications were given in divided doses morning and evening.
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Clinica Pediatrica dell'Universita di Modena, 41100 Modena, Italy.
D000927:Anticonvulsants / Q000627:therapeutic use*; D002675:Child, Preschool; D006801:Humans; D010634:Phenobarbital / Q000627:therapeutic use; D011324:Primidone / Q000627:therapeutic use; D003294:Seizures, Febrile / Q000517:prevention & control*; D014635:Valproic Acid / Q000627:therapeutic use*
D000927:Anticonvulsants; D011324:Primidone; D014635:Valproic Acid; D010634:Phenobarbital