title: GC/MS analysis of m-hydroxybenzoylecgonine in urine. Forensic implication in cocaine use.
abstract: m-Hydroxybenzoylecgonine (m-OH-BE) and d3-m- hydroxybenzoylecgonine (d3-m-OH-BE) have been synthesized, and a GC/MS procedure with d3-m-OH-BE as internal standard has been developed. Among 24 human urine specimens that were positive for BE, all of them have shown detectable levels of m-OH-BE with 75% of the specimens exceeding the LoQ (5 ng/mL), compared with only 50% of the specimens containing detectable levels of EME. The presence of m-OH-BE in urine suggested that this metabolite may serve as a valuable marker of cocaine use in addition to BE and EME.
authors.affiliation: ElSohly Laboratories, Incorporated, Oxford, Mississippi, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: elSohly
authors.forename: W J
authors.initials: WJ
authors.lastname: Kopycki
authors.forename: S
authors.initials: S
authors.lastname: Feng
authors.forename: T P
authors.initials: TP
authors.lastname: Murphy
authors.forename: B J
authors.initials: BJ
authors.lastname: Lukey
mesh_terms: D003042:Cocaine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000493:pharmacokinetics / Q000652:urine; D019970:Cocaine-Related Disorders; D005554:Forensic Medicine; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006801:Humans
chemical_list: C085009:3-hydroxybenzoylecgonine; D003042:Cocaine