Effects of some sulfur-containing antioxidants on lead-exposed lenses.
Lead (Pb) is known to negatively affect glutathione (GSH) metabolism in the lens. The present study examined the effects of Captopril, Taurine, and alpha-Lipoic acid on the Pb-induced GSH depletion and lipid peroxide increase in the lenticular system. Captopril administration returned the GSH, cysteine (CYS), and malondialdehyde (MDA) levels to near normal. Following Taurine administration the GSH, CYS and MDA levels were intermediate between the control group and the Pb group levels. Alpha-Lipoic acid administration, however, only increased the CYS levels. No significant changes in oxidized glutathione (GSSG) levels were observed in any treatment group.
Neal
R
R
Department of Chemistry, University of Missouri-Rolla, 65409, USA.
Cooper
K
K
Kellogg
G
G
Gurer
H
H
Ercal
N
N
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D002216:Captopril / Q000494:pharmacology; D003545:Cysteine / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D019803:Glutathione Disulfide / Q000378:metabolism; D007854:Lead / Q000633:toxicity*; D007908:Lens, Crystalline / Q000187:drug effects* / Q000378:metabolism*; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D011916:Rats, Inbred F344; D017382:Reactive Oxygen Species / Q000378:metabolism; D013455:Sulfur / Q000737:chemistry; D013654:Taurine / Q000494:pharmacology; D008063:Thioctic Acid / Q000494:pharmacology
D000975:Antioxidants; D008054:Lipid Peroxides; D017382:Reactive Oxygen Species; D013654:Taurine; D007854:Lead; D008315:Malondialdehyde; D013455:Sulfur; D008063:Thioctic Acid; D002216:Captopril; D005978:Glutathione; D003545:Cysteine; D019803:Glutathione Disulfide