title: Dietary lipids influence intestinal adaptation after massive bowel resection.
abstract: BACKGROUND
  Certain lipids, primarily long chain fatty acids and especially long chain polyunsaturated fatty acids (LCPUFAs) from marine oils, stimulate gut adaptation after resection. The goal of this study was to define the degree of resection that provides an optimal model for adaptation and to determine if dietary LCPUFAs improve intestinal adaptation after resection.
  
  
  METHODS
  One hundred and fifty-g male Sprague-Dawley rats were divided into groups receiving 60%, 70%, and 80% bowel resection. After resection, each group was subdivided into two dietary groups and pair fed diets containing either safflower oil or docosahexaenoic acid (DHA) and arachidonic (AA).
  
  
  RESULTS
  After 2 weeks, mucosal mass, protein, DNA, and disaccharidase activity were measured in the remaining intestine. Rats receiving 80% resection responded with the highest level of intestinal adaptation. Within the 80% resection group, diet containing DHA and AA stimulated adaptation significantly more than safflower diet. A second study further evaluated the effect on LCPUFAs on intestinal adaptation. Diets included a control group 10% soy oil, and three diets differing in their AA-DHA fat blend ratio at 5% AA and 3.3% DHA, 15% AA and 10% DHA, and 45% AA and 30% DHA. The addition of LCPUFAs to diets enhanced intestinal adaptation in a linear, dose-dependent manner after an 80% small bowel resection. Rats fed a diet containing 30% DHA-45% AA had significantly enhanced mucosal mass compared to rats fed a diet containing 10% soy oil, and considerably higher compared to rats fed 3.3% DHA-5% AA.
  
  
  CONCLUSIONS
  These studies suggest that modification of dietary LCPUFAs may enhance intestinal adaptation in short bowel syndrome.
authors.affiliation: The Center for Human Nutrition, Omaha, Nebraska, USA.
authors.forename: K A
authors.initials: KA
authors.lastname: Kollman
authors.forename: E L
authors.initials: EL
authors.lastname: Lien
authors.forename: J A
authors.initials: JA
authors.lastname: Vanderhoof
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects*; D000818:Animals; D016718:Arachidonic Acid / Q000494:pharmacology; D004041:Dietary Fats / Q000494:pharmacology*; D004281:Docosahexaenoic Acids / Q000494:pharmacology; D007421:Intestine, Small / Q000187:drug effects* / Q000502:physiology / Q000601:surgery*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012450:Safflower Oil / Q000494:pharmacology; D012778:Short Bowel Syndrome / Q000178:diet therapy*
chemical_list: D004041:Dietary Fats; D004281:Docosahexaenoic Acids; D016718:Arachidonic Acid; D012450:Safflower Oil