title: Severe exacerbation of liver disease during pregnancy in a thalassemic GBV-C/HGV-positive patient and neonatal hepatitis in offspring.
abstract: The case of a young woman with GB virus C/hepatitis G virus (GBV-C/HGV) infection and with a severe exacerbation of chronic hepatitis of unknown etiology during pregnancy is described. In the offspring, severe neonatal hepatitis with subsequent mild chronic liver disease of at least 16-month duration was followed by the development of antibodies to the envelope protein (E2) of GBV-C/HGV, suggesting that the child was recovering from GBV-C/HGV infection. There was an improvement in clinical and biochemical parameters in the mother following delivery and alpha-interferon therapy was associated with a transient biochemical response.
authors.affiliation: Department of Gastroenterology, Cliniques Universitaires Saint Luc, Louvain Medical School, Brussels, Belgium.
authors.forename: Y
authors.initials: Y
authors.lastname: Horsmans
authors.forename: P
authors.initials: P
authors.lastname: Karayiannis
authors.forename: J L
authors.initials: JL
authors.lastname: Christophe
authors.forename: J M
authors.initials: JM
authors.lastname: Pickering
authors.forename: C
authors.initials: C
authors.lastname: Debauche
authors.forename: C
authors.initials: C
authors.lastname: Cornu
authors.forename: J
authors.initials: J
authors.lastname: Rahier
authors.forename: G
authors.initials: G
authors.lastname: Hess
authors.forename: H C
authors.initials: HC
authors.lastname: Thomas
authors.forename: A P
authors.initials: AP
authors.lastname: Geubel
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D001707:Biopsy, Needle; D005260:Female; D018067:Flaviviridae / Q000276:immunology / Q000302:isolation & purification*; D006525:Hepatitis, Viral, Human / Q000097:blood / Q000150:complications* / Q000276:immunology / Q000473:pathology / Q000628:therapy; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D016898:Interferon-alpha / Q000627:therapeutic use; D008111:Liver Function Tests; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology*; D012367:RNA, Viral / Q000097:blood; D017086:beta-Thalassemia / Q000150:complications*
chemical_list: D000914:Antibodies, Viral; D016898:Interferon-alpha; D012367:RNA, Viral