Embryonic asymmetry: the left side gets all the best genes.
The origin of left-right developmental asymmetry is a continuing puzzle, but some recent results provide new insights into the steps leading to organ asymmetry - implicating the homeobox protein Pitz-2 in one key step - and others support a model of symmetry-breaking that involves the chirality of microtubules.
King
T
T
Department of Anatomy and Developmental Biology, St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK.
Brown
N A
NA
D000818:Animals; D019521:Body Patterning / Q000235:genetics* / Q000502:physiology; D004625:Embryo, Nonmammalian; D018398:Homeodomain Proteins / Q000235:genetics* / Q000502:physiology; D008870:Microtubules / Q000502:physiology*; D009687:Nuclear Proteins; D051761:Paired Box Transcription Factors; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics; D000097577:Homeobox Protein PITX2
D018398:Homeodomain Proteins; D009687:Nuclear Proteins; D051761:Paired Box Transcription Factors; D014157:Transcription Factors; D000097577:Homeobox Protein PITX2; C101485:homeobox protein PITX1; C433629:homeobox protein PITX3