[Autoimmune hypothyroidism].
Most of the acquired hypothyroidisms are related to chronic lymphocytic thyroiditis which reduce the functional thyroid parenchyma, determine acquired organification disorders or rarely generation of blocking anti-TSH receptor antibodies. In subjects with genetic predisposition, autoimmunization against the thyroid involves recognition of thyroid antigens, cooperation between B and T lymphocytes and production of cytokines. Biologic markers of antithyroid autoimmune disorders are now widely available. Nevertheless therapeutic approach of autoimmune hypothyroidisms is still symptomatic: thyroid hormone is able to correct hypothyroidism, to reduce the volume of goiter if present and also to lower the biological evidence of thyroid autoimmunity.
Wémeau
J L
JL
Clinique endocrinologique, Marc Linquette-USN A, Hôpital Roger-Salengro, CHRU 59037 Lille.
d'Herbomez-Boidein
M
M
D006042:Goiter / Q000188:drug therapy; D006801:Humans; D007037:Hypothyroidism / Q000188:drug therapy / Q000276:immunology* / Q000503:physiopathology; D013963:Thyroid Hormones / Q000627:therapeutic use; D013967:Thyroiditis, Autoimmune / Q000503:physiopathology*
D013963:Thyroid Hormones