title: Spatial memory impairment in ventral subicular lesioned rats.
abstract: The present study examined the effects of ibotenic acid lesions of the ventral subiculum (SUB) on the ability of rats to memorize a rewarded alternation test in a T-maze. Results indicated that rats with ibotenic acid lesions (IL) of the ventral subiculum were impaired in postoperative acquisition of the spatial discrimination task, making more errors than the vehicle treated and normal control rats. In addition, all rats, including the IL group of rats, were able to memorize an acquired spatial behaviour. These findings suggest that the SUB play an important role in spatial information processing in rats.
authors.affiliation: Department of Neurophysiology, National Institute of Mental Health and Neurosciences, P.B. 2900, Hosur Road, Bangalore-560 029, Karnataka, India.
authors.forename: T R
authors.initials: TR
authors.lastname: Laxmi
authors.forename: P N
authors.initials: PN
authors.lastname: Bindu
authors.forename: T R
authors.initials: TR
authors.lastname: Raju
authors.forename: B L
authors.initials: BL
authors.lastname: Meti
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D003216:Conditioning, Operant / Q000502:physiology; D006624:Hippocampus / Q000502:physiology*; D007051:Ibotenic Acid / Q000008:administration & dosage; D008297:Male; D018782:Maze Learning / Q000502:physiology; D008568:Memory / Q000502:physiology*; D008569:Memory Disorders / Q000139:chemically induced*; D008845:Microinjections; D051381:Rats; D017208:Rats, Wistar; D012153:Retention, Psychology / Q000502:physiology; D013037:Spatial Behavior / Q000502:physiology*; D014851:Wakefulness
chemical_list: D007051:Ibotenic Acid