title: Frontosubcortical neuroanatomy and the continuous performance test in mania.
abstract: OBJECTIVE
  The authors examined whether Continuous Performance Test scores correlate with frontosubcortical volumes in bipolar disorder.
  
  
  METHODS
  The subjects were 17 patients hospitalized for an acute manic episode and 12 group-matched comparison subjects. They underwent magnetic resonance imaging and completed the Continuous Performance Test.
  
  
  RESULTS
  The patients performed worse on the Continuous Performance Test and had smaller prefrontal cortical volumes than the comparison subjects. Within the patient group, Continuous Performance Test performance significantly correlated with prefrontal and hippocampal volumes.
  
  
  CONCLUSIONS
  These results suggest that certain neuroanatomic structures may be associated with attentional dysfunction in mania.
authors.affiliation: Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267-0559, USA. saxkw@email.uc.edu
authors.forename: K W
authors.initials: KW
authors.lastname: Sax
authors.forename: S M
authors.initials: SM
authors.lastname: Strakowski
authors.forename: M E
authors.initials: ME
authors.lastname: Zimmerman
authors.forename: M P
authors.initials: MP
authors.lastname: DelBello
authors.forename: P E
authors.initials: PE
authors.lastname: Keck
authors.forename: J M
authors.initials: JM
authors.lastname: Hawkins
mesh_terms: D000293:Adolescent; D000328:Adult; D001288:Attention / Q000502:physiology; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000503:physiopathology; D001921:Brain / Q000033:anatomy & histology* / Q000503:physiopathology; D002421:Caudate Nucleus / Q000033:anatomy & histology / Q000503:physiopathology; D006624:Hippocampus / Q000033:anatomy & histology / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D017397:Prefrontal Cortex / Q000033:anatomy & histology* / Q000503:physiopathology; D013788:Thalamus / Q000033:anatomy & histology / Q000503:physiopathology