Exploratory thoughts on clinical trials with utilities.
We consider problems of choice of sample size and allocation in the clinical trials context when utilities are explicitly taken into account. In particular, we consider utilities of benefits and side-effects (and their trade-offs), as well as utility functions that trade-off scientific and ethical concerns.
Tan
S B
SB
Department of Mathematics, Imperial College of Science, Technology & Medicine, London, U.K.
Smith
A F
AF
D001499:Bayes Theorem; D002986:Clinical Trials as Topic / Q000379:methods / Q000706:statistics & numerical data; D006801:Humans; D015233:Models, Statistical; D018401:Sample Size; D016008:Statistical Distributions