Sjögren's syndrome with acute renal failure.
We experienced a 65-year-old woman with Sjögren's syndrome who presented with acute renal failure, hypergammaglobulinemia with monoclonal gammopathy, and hypocomplementemia. She improved with steroid pulse therapy (methylprednisolone 0.5 g/day for 3 days). This patient had also sensorineural hearing loss, symmetric sensory polyneuropathy of legs, and interstitial lung disease. Ten months after recovery from acute renal failure, low-dose oral prednisolone (0.1 mg/kg/day) was withdrawn. On the third month of steroid withdrawal, acute renal failure recurred with hypergammaglobulinemia, hyperamylasemia, and autoimmune cholangitis-like biochemical derangements, which also responded to steroid pulse therapy (methylprednisolone 0.3 g/day for 3 days). When we would withdraw steroid in a patient with visceral involvement of Sjögren's syndrome, we should consider multiple clinical and laboratorial variables, including erythrocyte sedimentation rate, serum levels of IgG, total protein, C3/C4, CRP, amylase, lipase, and alkaline phosphatase. We report this case which exhibited various unusual manifestations with a review of literature.
Kwon
Y J
YJ
Department of Internal Medicine, Korea University, Seoul. toitoi@hitel.net.
Park
J H
JH
Kim
S W
SW
Han
S Y
SY
Pyo
H J
HJ
Won
N H
NH
D058186:Acute Kidney Injury / Q000150:complications* / Q000473:pathology*; D000368:Aged; D005260:Female; D006801:Humans; D012859:Sjogren's Syndrome / Q000150:complications* / Q000473:pathology*