Application of chiral chromatographic parameters in quantitative structure-activity relationship analysis of homologous malathion derivatives.
The conditions of the chiral resolution of the racemic malathion O,O-di-n-alkyl derivatives on cellulose tris(3,5-dimethylphenylcarbamate) are described. Quantitative relationships between chromatographic parameters obtained on chiral and achiral stationary phases and acute toxicity of the compounds towards house fly are derived and discussed.
Chilmonczyk
Z
Z
Pharmaceutical Research Institute, Warsaw, Poland.
Ksycińska
H
H
Poleć
I
I
D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D007306:Insecticides / Q000737:chemistry*; D008294:Malathion / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D007306:Insecticides; D008294:Malathion