A case of clofazimine enteropathy.
A case of clofazimine enteropathy is described. A young male received clofazimine 200 mg daily for four years. He was admitted in a pigmented, emaciated state with abdominal pain, diarrhoea and weight loss. At laparotomy his abdominal organs were stained with dark brown-black pigment due to heavy infiltration with clofazimine crystals. Despite withdrawal of clofazimine his symptoms failed to settle. He developed oedema and hypoalbuminaemia. He died following a cerebral infarction.
Hameed
A
A
Yeovil District Hospital, Somerset, UK.
Beach
F X
FX
Kennedy
R H
RH
Barry
R E
RE
D000293:Adolescent; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D002991:Clofazimine / Q000009:adverse effects*; D017809:Fatal Outcome; D006801:Humans; D007410:Intestinal Diseases / Q000139:chemically induced* / Q000473:pathology; D007422:Intestines / Q000473:pathology; D008297:Male; D010859:Pigmentation Disorders / Q000139:chemically induced*; D012883:Skin Ulcer / Q000188:drug therapy
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002991:Clofazimine