title: Phosphorylcholine Coating of Iron Oxide Nanoparticles.
abstract: In order to develop thin-walled superparamagnetic nanoparticle suspensions as a contrast agent for magnetic resonance imaging, phosphorylcholine PC was used to coat iron oxide cores of 5 nm. Weak stable positively charged suspensions can be obtained at concentration greater than 3 mmol.l-1 (corresponding to about 3.2 molecules per nm2), while the addition of phosphorylglycerol PG decreases the electrophoretic mobility. Raising the pH over 6 leads to flocculation: the binding of PC on iron oxides as a function of pH appears to be reversible. By Langmuir analysis, two adsorption domains may be observed with a maximal density of 3.48 and 6.55 mol.nm-2, interpreted as a multilayer formation. Copyright 1999 Academic Press.
authors.affiliation: UPRESEA 2169 Vectorisation Particulaire, 1 rue Haute de Reculée, Angers, F 49045, France
authors.initials: B
authors.lastname: Denizot
authors.initials: G
authors.lastname: Tanguy
authors.initials: F
authors.lastname: Hindre
authors.initials: E
authors.lastname: Rump
authors.lastname: Jacques Le Jeune J
authors.initials: P
authors.lastname: Jallet