[Heparin-piracetam complex and its effect on blood and blood circulation].
High-molecular-weight heparin-piracetam complex (1:1 w/w ratio) was obtained in vitro. The complex, its components, or physiological solution were introduced intraperitoneally in rats (0.3 ml, 0.1%). Piracetam had no effect on homeostasis. The heparin-piracetam complex had a more pronounced anticoagulant and fibrinolytic activities than the individual components. In addition, this complex accelerated blood flow in the brain. In conditions of acute hypoxia (a 12,000-m altitude chamber), heparin protected animals from hypoxia more effectively than other substances.
Kondashevskaia
M V
MV
Moscow State University, Faculty of Biology, Moscow, Russia.
Liapina
L A
LA
D000208:Acute Disease; D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D006487:Hemostasis; D006493:Heparin / Q000494:pharmacology*; D000860:Hypoxia / Q000517:prevention & control; D010889:Piracetam / Q000494:pharmacology*; D051381:Rats
D000925:Anticoagulants; C117412:heparin-piracetam complex; D006493:Heparin; D010889:Piracetam