title: Acquired factor VIII inhibitors--successful treatment with an oral outpatient regimen.
abstract: A rare cause of a spontaneous, life threatening coagulopathy in adults is the development of autoantibodies to factor VIII. We recently had the opportunity to treat seven patients with this disorder. After stabilization, they were given a regimen consisting of prednisone and oral cyclophosphamide. All patients had a complete response to treatment. The median time to response was three weeks. Durable remissions were achieved, making this oral regimen an acceptable treatment for this disorder.
authors.affiliation: Department of Medicine, North Shore University Hospital-New York University School of Medicine, Manhasset 11030, USA.
authors.forename: R L
authors.initials: RL
authors.lastname: Bayer
authors.forename: S M
authors.initials: SM
authors.lastname: Lichtman
authors.forename: S L
authors.initials: SL
authors.lastname: Allen
authors.forename: D R
authors.initials: DR
authors.lastname: Budman
authors.forename: A
authors.initials: A
authors.lastname: Buchbinder
authors.forename: J
authors.initials: J
authors.lastname: Fetten
authors.forename: J
authors.initials: J
authors.lastname: Kolitz
authors.forename: J
authors.initials: J
authors.lastname: Loscalzo
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000553:Ambulatory Care; D001323:Autoantibodies / Q000097:blood; D001327:Autoimmune Diseases / Q000188:drug therapy; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use; D004338:Drug Combinations; D005169:Factor VIII / Q000276:immunology*; D005260:Female; D006467:Hemophilia A / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use; D012074:Remission Induction
chemical_list: D001323:Autoantibodies; D004338:Drug Combinations; D003520:Cyclophosphamide; D005169:Factor VIII; D011241:Prednisone