Orthotopic liver transplantation for hepatitis C infection: the best Christmas present?
We report the case of a 60-year-old man with mild Christmas disease, Factor IX 10% of normal, who developed chronic hepatitis C infection after receiving coagulation factor concentrates. Subsequently he developed encephalopathy and liver failure and was referred for liver transplantation. Following transplantation, Factor IX levels rapidly normalised and have remained so, representing a phenotypic cure of his Christmas disease.
Johnston
S D
SD
Department of Medicine, Royal Victoria Hospital, Belfast.
McNulty
O
O
Mayne
E
E
Callender
M E
ME
D001779:Blood Coagulation Factors / Q000008:administration & dosage; D005164:Factor IX / Q000378:metabolism; D002836:Hemophilia B / Q000097:blood / Q000150:complications* / Q000628:therapy; D019698:Hepatitis C, Chronic / Q000097:blood / Q000150:complications* / Q000601:surgery; D006801:Humans; D017093:Liver Failure / Q000097:blood / Q000209:etiology* / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged
D001779:Blood Coagulation Factors; D005164:Factor IX