title: Gamma interferon is a major suppressive factor produced by activated human peripheral blood lymphocytes that is able to inhibit foamy virus-induced cytopathic effects.
abstract: The activation of human peripheral blood lymphocytes by mitogens or by triggering the T-cell receptor with anti-CD3 antibodies leads to the production of a potent soluble inhibitory activity against foamy virus-induced cytopathic effects in vitro. The inhibitory activity acts in a species-specific manner. As a consequence, the isolation of foamy viruses from blood lymphocytes of infected humans is accelerated in a heterologous coculture system. Antibodies against gamma interferon (IFN-gamma) are able to suppress most of the inhibitory activity, suggesting that IFN-gamma is the dominant component.
authors.affiliation: Abteilung Virologie, Institut für Medizinische Mikrobiologie und Hygiene, Universität Freiburg, D-79104 Freiburg, Germany.
authors.forename: V
authors.initials: V
authors.lastname: Falcone
authors.forename: M
authors.initials: M
authors.lastname: Schweizer
authors.forename: A
authors.initials: A
authors.lastname: Toniolo
authors.forename: D
authors.initials: D
authors.lastname: Neumann-Haefelin
authors.forename: A
authors.initials: A
authors.lastname: Meyerhans
mesh_terms: D016475:3T3 Cells; D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D003588:Cytopathogenic Effect, Viral; D000882:Haplorhini; D006801:Humans; D007371:Interferon-gamma / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D016092:Spumavirus / Q000276:immunology* / Q000502:physiology
chemical_list: D007371:Interferon-gamma