title: Tissue engineering: the first decade and beyond.
abstract: This article reviews the important developments in the field of tissue engineering over the last 10 years. Research in the area of biomaterials is examined from the perspective of providing the foundation for the development of tissue engineering. Early efforts combining cells with biocompatible materials are described and applications of this technology presented, with particular focus on uses in orthopaedics and maxillofacial surgery. The basic principles of tissue engineering and state-of-the-art technology in cell biology and materials science as used currently in the field are presented. Finally, futures challenges are outlined from the perspective of integrating technologies from medicine, biology, and engineering, in hopes of translating tissue engineering to clinical applications.
authors.affiliation: Department of Anesthesiology, University of Massachusetts Medical School, Worcester 01655, USA. lawrence.bonassar@ummed.edu
authors.forename: L J
authors.initials: LJ
authors.lastname: Bonassar
authors.forename: C A
authors.initials: CA
authors.lastname: Vacanti
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use; D001698:Biomedical Engineering / Q000379:methods* / Q000639:trends*; D006801:Humans
chemical_list: D001672:Biocompatible Materials