Analysis of the VIQ scores of families of three or more Orkney brothers.
Classification of the boys in 48 families of three or more brothers according to their Moray House Test (VIQ) scores awarded at age 11 +/- 1 1/2 years in 1947-75 confirms the postulated existence of a total of nine male phenotypes for this X-linked trait in the score range < 70 to 140 points. The phenotypic means lie close to the sequence 69(8)133. Recombination is shown to occur. An additive effect of three alleles at each of two X-chromosome loci is the most likely simple scheme. An iterative approach matching the observed mixtures of proposed genotypes in the families with probabilities for variable levels of homozygosity, non-crossover/crossover heterozygosity, and maternal meiotic recombination yields a best goodness of fit where this last is 20%.
Goodman
J D
JD
Anderton
R B
RB
D015982:Bias; D002648:Child; D003434:Crossing Over, Genetic; D008040:Genetic Linkage / Q000235:genetics*; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007360:Intelligence / Q000235:genetics*; D008297:Male; D005810:Multigene Family / Q000235:genetics; D010641:Phenotype; D011995:Recombination, Genetic / Q000235:genetics; D012606:Scotland; D012727:Sex Characteristics; D014705:Verbal Behavior; D014960:X Chromosome / Q000235:genetics*