title: Absorption and retention of nickel from drinking water in relation to food intake and nickel sensitivity.
abstract: Two studies were performed to examine the influence of fasting and food intake on the absorption and retention of nickel added to drinking water and to determine if nickel sensitization played any role in this regard. First, eight nonallergic male volunteers fasted overnight before being given nickel in drinking water (12 micrograms Ni/kg) and, at different time intervals, standardized 1400-kJ portions of scrambled eggs. When nickel was ingested in water 30 min or 1 h prior to the meal, peak nickel concentrations in serum occurred 1 h after the water intake, and the peak was 13-fold higher than the one seen 1 h after simultaneous intake of nickel-containing water and scrambled eggs. In the latter case, a smaller, delayed peak occurred 3 h after the meal. Median urinary nickel excretion half-times varied between 19.9 and 26.7 h. Within 3 days, the amount of nickel excreted corresponded to 2.5% of the nickel ingested when it was mixed into the scrambled eggs. Increasing amounts were excreted as the interval between the water and the meal increased, with 25.8% of the administered dose being excreted when the eggs were served 4 h prior to the nickel-containing drinking water. In the second experiment, a stable nickel isotope, 61Ni, was given in drinking water to 20 nickel-sensitized women and 20 age-matched controls, both groups having vesicular hand eczema of the pompholyx type. Nine of 20 nickel allergic eczema patients experienced aggravation of hand eczema after nickel administration, and three also developed a maculopapular exanthema. No exacerbation was seen in the control group. The course of nickel absorption and excretion in the allergic groups did not differ and was similar to the pattern seen in the first study, although the absorption in the women was less. A sex-related difference in gastric emptying rates may play a role. Thus, food intake and gastric emptying are of substantial significance for the bioavailability of nickel from aqueous solutions.
authors.affiliation: Department of Environmental Medicine, Odense University, Odense, 5000, Denmark.
authors.forename: G D
authors.initials: GD
authors.lastname: Nielsen
authors.forename: U
authors.initials: U
authors.lastname: Søderberg
authors.forename: P J
authors.initials: PJ
authors.lastname: Jørgensen
authors.forename: D M
authors.initials: DM
authors.lastname: Templeton
authors.forename: S N
authors.initials: SN
authors.lastname: Rasmussen
authors.forename: K E
authors.initials: KE
authors.lastname: Andersen
authors.forename: P
authors.initials: P
authors.lastname: Grandjean
mesh_terms: D000042:Absorption; D000328:Adult; D017449:Dermatitis, Allergic Contact / Q000378:metabolism*; D004435:Eating; D004485:Eczema / Q000209:etiology; D004531:Eggs; D005215:Fasting; D005260:Female; D005746:Gastric Emptying; D006801:Humans; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D009532:Nickel / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012727:Sex Characteristics; D014867:Water
chemical_list: D014867:Water; D009532:Nickel