title: Heterogeneity of cadherin-8 expression in the neonatal rat striatum: comparison with striatal compartments.
abstract: Mechanisms of organization of the striatal compartments are poorly understood, although involvement of cell adhesion molecules in the compartmentalization has been suggested. Cadherin-8 distribution in the neonatal rat striatum was immunohistochemically studied using a rabbit anti-cadherin-8 antiserum. Intensity of cadherin-8 immunolabeling in the striatum was heterogeneous from postnatal day 0 to postnatal day 7. At postnatal day 9, cadherin-8 immunoreactivity was so weak that heterogeneity was no longer clearly seen. Cadherin-8 immunoreactivity was not detectable at postnatal day 14. Cadherin-8-rich and cadherin-8-poor areas were identical to calbindin-rich areas and tyrosine hydroxylase-rich patches, respectively, in allocation, indicating that cadherin-8 was predominantly expressed in the striatal matrix. These results suggest that cadherin-8 is involved in formation of the striatal compartmentalized structures during brain development.
authors.affiliation: Department of Neurosurgery, Kumamoto University Medical School, Kumamoto, 860, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Korematsu
authors.forename: S
authors.initials: S
authors.lastname: Goto
authors.forename: A
authors.initials: A
authors.lastname: Okamura
authors.forename: Y
authors.initials: Y
authors.lastname: Ushio
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000906:Antibodies; D001923:Brain Chemistry / Q000235:genetics; D015820:Cadherins / Q000032:analysis / Q000235:genetics* / Q000276:immunology; D064026:Calbindins; D003342:Corpus Striatum / Q000737:chemistry* / Q000166:cytology / Q000254:growth & development*; D018507:Gene Expression Regulation, Developmental; D018740:Genetic Heterogeneity; D051379:Mice; D008807:Mice, Inbred BALB C; D009474:Neurons / Q000737:chemistry / Q000201:enzymology; D051381:Rats; D017208:Rats, Wistar; D064030:S100 Calcium Binding Protein G / Q000235:genetics; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis / Q000276:immunology
chemical_list: D000906:Antibodies; D015820:Cadherins; D064026:Calbindins; C504541:Cdh8 protein, mouse; C504540:Cdh8 protein, rat; D064030:S100 Calcium Binding Protein G; D014446:Tyrosine 3-Monooxygenase