title: The natural history of multiple sclerosis and its diagnosis.
abstract: The definition of multiple sclerosis (MS) provides a framework for the findings of the disease. This definition encompasses multiple lesions in the central nervous system which appear over time and emphasizes the spacial distribution of the lesions. Due to the significant degree of variability in the presentation of MS, the definition has evolved in terms of probability for the diagnosis given the findings.
authors.affiliation: Spinal Cord Injury and Neuro-Orthopedic Division, Gaylord Hospital, Wallingford, Connecticut, USA.
authors.forename: D
authors.initials: D
authors.lastname: Rosenblum
authors.forename: M
authors.initials: M
authors.lastname: Saffir
mesh_terms: D001927:Brain Diseases / Q000503:physiopathology; D003937:Diagnosis, Differential; D018450:Disease Progression; D005071:Evoked Potentials / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000145:classification / Q000175:diagnosis / Q000276:immunology / Q000503:physiopathology*; D011336:Probability; D014057:Tomography, X-Ray Computed