Knee and/or hip joint destruction in rheumatoid arthritis is associated with HLA-DRB1*0405 in Japanese patients.
To determine the prognostic factors for knee and/or hip joint destruction in rheumatoid arthritis (RA) patients, we typed 379 RA patients for HLA-DRB alleles and analysed the antigen frequencies. The DRB1*0405 antigen frequency in RA patients who underwent total knee replacement and/or total hip replacement was significantly higher than in those who did not have replacements, which meant that DRB1*0405 was associated with knee and/or hip joint destruction. This finding may be of value for predicting knee and/or hip joint destruction in RA.
Wakitani
S
S
Department of Orthopaedic Surgery, Osaka-Minami National Hospital, Kawachinagano, Japan.
Kuwata
K
K
Imoto
K
K
Murata
N
N
Oonishi
H
H
Ochi
T
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000276:immunology / Q000601:surgery; D019644:Arthroplasty, Replacement, Hip; D019645:Arthroplasty, Replacement, Knee; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006684:HLA-DR Antigens / Q000235:genetics / Q000276:immunology*; D059811:HLA-DRB1 Chains; D006621:Hip Joint / Q000276:immunology / Q000473:pathology; D006801:Humans; D007564:Japan; D007719:Knee Joint / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000150:complications* / Q000276:immunology / Q000601:surgery; D020370:Osteoarthritis, Knee / Q000150:complications* / Q000276:immunology / Q000601:surgery; D011379:Prognosis
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains