Embryonic induction: is the Nieuwkoop centre a useful concept?
Regionalisation of the amphibian embryo is classically thought to involve induction by the Spemann organiser, itself induced by the Nieuwkoop centre. This model has now been extended to teleosts, with the identification of a gene that appears to define the zebrafish equivalent of the Nieuwkoop centre.
Kodjabachian
L
L
NIH, NICHD, Laboratory of Molecular Genetics, 9000 Rockville Pike, Bethesda, Maryland 20892, USA. kodja@nih.gov
Lemaire
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P
D000818:Animals; D019521:Body Patterning; D003598:Cytoskeletal Proteins / Q000502:physiology; D004627:Embryonic Induction; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D006801:Humans; D012333:RNA, Messenger / Q000502:physiology; D015534:Trans-Activators; D029867:Xenopus Proteins; D014982:Xenopus laevis; D015027:Zebrafish; D029961:Zebrafish Proteins; D051176:beta Catenin
C495266:CTNNB1 protein, Xenopus; C495270:CTNNB1 protein, human; D003598:Cytoskeletal Proteins; D018398:Homeodomain Proteins; D012333:RNA, Messenger; C093133:SIA1 protein, Xenopus; D015534:Trans-Activators; D029867:Xenopus Proteins; D029961:Zebrafish Proteins; D051176:beta Catenin; C495269:ctnnb1 protein, zebrafish; C113874:dharma protein, zebrafish