Pentoxifylline and skin inflammation.
Cyclic nucleotide phosphodiesterase inhibitors, such as pentoxifylline, have been shown to beneficially influence a large number of inflammatory skin diseases. The biological effects of pentoxifylline on the production of proinflammatory cytokines, leukocyte-endothelial cell adhesion, chemokines and leukocyte-keratinocyte adhesion in skin inflammation are discussed.
Bruynzeel
I
I
Department of Dermatology, Free University Hospital, Amsterdam, The Netherlands.
Stoof
T J
TJ
Willemze
R
R
D002448:Cell Adhesion / Q000187:drug effects; D016207:Cytokines / Q000096:biosynthesis; D003872:Dermatitis / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D010431:Pentoxifylline / Q000627:therapeutic use*; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use*
D016207:Cytokines; D010726:Phosphodiesterase Inhibitors; D010431:Pentoxifylline