title: Velcro in the nuclear envelope: LBR and LAPs.
abstract: The nuclear envelope is crucial for the functional organization of the nucleus. Lamin B receptor (LBR) and several lamina-associated proteins (LAPs), residing in the inner membrane, provide attachment sites for chromatin and the nuclear lamina. LAPs and LAP-related proteins are members of a growing family of proteins, whose genes are expressed in a tissue and development specific manner, opening the opportunity for a complex regulation of membrane-chromatin and membrane-lamina interactions. Post-translational modifications of LBR and LAPs are likely to modulate their binding to lamins and chromatin, interactions that need to be dynamic to accommodate nuclear growth in interphase and nuclear envelope disassembly in mitosis. Accumulation of proteins in the inner nuclear membrane is believed to depend on their retention mediated by the interaction with nuclear components such as chromatin and lamins.
authors.affiliation: Department of Physiology, Montreal, Que, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Chu
authors.forename: R
authors.initials: R
authors.lastname: Rassadi
authors.forename: U
authors.initials: U
authors.lastname: Stochaj
mesh_terms: D007797:Laminin / Q000378:metabolism*; D009685:Nuclear Envelope / Q000378:metabolism*; D010766:Phosphorylation; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D000097682:Lamin B Receptor
chemical_list: D007797:Laminin; D018160:Receptors, Cytoplasmic and Nuclear; D000097682:Lamin B Receptor