Viral vectors for veterinary vaccines.
Whatever strategy is adopted for the development of viral vectors for delivery of veterinary vaccines there are several key points to consider: (1) Will the vectored vaccine give a delivery advantage compared to what's already available? (2) Will the vectored vaccine give a manufacturing advantage compared to what's already available? (3) Will the vectored vaccine provide improved safety compared to what's already available? (5) Will the vectored vaccine increase the duration of immunity compared to what's already available? (6) Will the vectored vaccine be more convenient to store compared to what's already available? (7) Is the vectored vaccine compatible with other vaccines? If there is no other alternative available then the answer to these questions is easy. However, if there are alternative vaccines available then the answers to these questions become very important because the answers will determine whether a vectored vaccine is merely a good laboratory idea or a successful vaccine.
Sheppard
M
M
Animal Health Biological Discovery, Pfizer Central Research, Groton, Connecticut 06340, USA.
D000818:Animals; D017353:Gene Deletion; D005814:Genes, Viral; D005822:Genetic Vectors; D014611:Vaccination / Q000662:veterinary*; D014765:Viral Vaccines; D014777:Virus Diseases / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D014779:Virus Replication; D014780:Viruses / Q000235:genetics*
D014765:Viral Vaccines