Effects of intraduodenal administration of tarazepide on pancreatic secretion and duodenal EMG in neonatal calves.
The influence of CCK-A receptor antagonism on pancreatic exocrine secretion and duodenal EMG, and the mechanism(s) involved in CCK-induced pancreatic secretion were studied in conscious calves. Seven 1-week-old calves were fitted with a pancreatic duct catheter, duodenal cannula and duodenal electrodes. Pancreatic exocrine secretion and duodenal EMG were studied following intraduodenal CCK-A receptor antagonist (Tarazepide), intravenous atropine, and intravenous or intraduodenal CCK-8 administrations. Tarazepide decreased duodenal electric activity, reduced interdigestive pancreatic secretion, especially protein; reduced cephalic and early postprandial (milk) induced secretion of bicarbonate and protein. Pancreatic protein secretion to intravenous CCK-8 was little affected by atropine, but was significantly reduced by Tarazepide+/-atropine; in contrast, protein secretion to intraduodenal CCK-8 was abolished by Tarazepide or atropine. We conclude that pre- and especially early postprandial pancreatic secretion are partly controlled via CCK-A (mainly mucosal) mediated mechanisms.
Zabielski
R
R
Department of Animal Physiology, Warsaw Agricultural University, Poland. romuald.zabielski@zoofys.lu.se
Leśniewska
V
V
Borlak
J
J
Gregory
P C
PC
Kiela
P
P
Pierzynowski
S G
SG
Barej
W
W
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001569:Benzodiazepines / Q000494:pharmacology*; D002417:Cattle; D004576:Electromyography / Q000187:drug effects; D004594:Electrophysiology; D005769:Gastrointestinal Motility / Q000187:drug effects; D008297:Male; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D010189:Pancreatic Juice / Q000187:drug effects; D043886:Receptor, Cholecystokinin A; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors*; D012844:Sincalide / Q000097:blood / Q000494:pharmacology
D043886:Receptor, Cholecystokinin A; D011949:Receptors, Cholecystokinin; D001569:Benzodiazepines; D001285:Atropine; D012844:Sincalide; C118031:tarazepide