Periodic limb movement disorder and restless legs syndrome in children with attention-deficit hyperactivity disorder.
Sleep disruption can lead to symptoms of attention-deficit hyperactivity disorder (ADHD) in children. Since periodic limb movement disorder and/or restless legs syndrome can cause sleep disruption, we assessed whether these two specific sleep disorders are likely to occur in children with ADHD. We asked a series of 69 consecutive parents of children with ADHD questions about the symptoms of periodic limb movement disorder. Based on a positive response to these periodic limb movement disorder queries, 27 children underwent all-night polysomnography. Eighteen children (aged 2 to 15 years) of the 27 (26% of the 69 children with ADHD) had 5 or more periodic leg movements in sleep per hour of sleep and had complaints of sleep disruption, thus fulfilling the criteria for periodic limb movement disorder. A comparably age- and sex-matched group of children referred to a sleep laboratory for sleep complaints but without ADHD showed only a 5% prevalence (2 of 38 subjects) of periodic leg movements in sleep (P=.017). Eight of the 18 children with ADHD and periodic limb movement disorder and one of the two control patients with periodic limb movement disorder had both a personal and parental history of restless legs syndrome symptomatology. This study further documents the occurrence of periodic limb movement disorder and restless legs syndrome in children and is the first large-scale study establishing a possible comorbidity between ADHD and periodic limb movement disorder. We propose that the sleep disruption associated with periodic limb movement disorder and restless legs syndrome and the motor restlessness of restless legs syndrome while awake could contribute to the inattention and hyperactivity seen in a subgroup of ADHD-diagnosed children.
Picchietti
D L
DL
Pediatric Neurology Department, Carle Clinic and University of Illinois at Urbana-Champaign, USA.
England
S J
SJ
Walters
A S
AS
Willis
K
K
Verrico
T
T
D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000209:etiology* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D004576:Electromyography; D005121:Extremities / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D009069:Movement Disorders / Q000150:complications / Q000503:physiopathology*; D012148:Restless Legs Syndrome / Q000150:complications / Q000503:physiopathology*; D012893:Sleep Wake Disorders / Q000150:complications / Q000503:physiopathology*