Interaction between food components and drugs. Part 6: Influence of starch degradation products on propranolol transport.
Interactions between different starch degradation products and propranolol (P) were studies using permeation experiments and affinity capillary electrophoresis (ACE). In the presence of maltooligosaccharides (MO), the transport of P across artificial lipid membranes was retarded. The most intensive interaction with the drug was found in the presence of the not-debranched MO from maize starch. The electrophoretic mobility mu of the drug was decreased in dependence of the MO concentration. However calculation of equilibrium binding constants from the ACE experiments was not possible because of the relatively weak influence of starch degradation products on the electrophoretic behaviour of the drug. With both methods the same tendency in strength of interactions between the different MO and P was found. Molecular parameters of the MO and their viscosity play a role in the interactions and in the decreased permeation of the drug.
Dongowski
G
G
German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany.
Neubert
R H
RH
Plätzer
M
M
Schwarz
M A
MA
Schnorrenberger
B
B
Anger
H
H
D001692:Biological Transport / Q000187:drug effects; D019075:Electrophoresis, Capillary; D018565:Food-Drug Interactions; D008823:Micelles; D010539:Permeability; D011134:Polysaccharides / Q000494:pharmacology*; D011433:Propranolol / Q000378:metabolism*; D013213:Starch / Q000378:metabolism*
D008823:Micelles; D011134:Polysaccharides; C008315:maltodextrin; D013213:Starch; D011433:Propranolol