Steroidogenic effect of peptide histidine-isoleucine (PHI) in vitro: comparison with VIP.
VIP and PHI originate from the same precursor, and the two peptides share considerable sequence homology. Present studies, however, revealed notable differences in their steroidogenic effect on isolated rat adrenocortical cells. VIP seems to act through the VIP and/or PACAP receptor while PHI acts, directly or by sensitivity increase, through the ACTH receptor.
Nowak
K W
KW
Department of Animal Physiology and Biochemistry, Poznan University of Agriculture, Poland. kwnowak@owl.au.poznan.pl
Malendowicz
L K
LK
D000302:Adrenal Cortex / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D000450:Aldosterone / Q000096:biosynthesis*; D000818:Animals; D003345:Corticosterone / Q000096:biosynthesis*; D005260:Female; D010451:Peptide PHI / Q000494:pharmacology*; D011863:Radioimmunoassay; D051381:Rats; D017208:Rats, Wistar; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology*
D010451:Peptide PHI; D014660:Vasoactive Intestinal Peptide; D000450:Aldosterone; D003345:Corticosterone