Assessment of myocardial response to pharmacologic interventions using an improved MR imaging technique to estimate T2 values.
OBJECTIVE
Our objective was to improve a previously developed MR imaging sequence for the in vivo estimation of the myocardial T2* value and to evaluate, in healthy human subjects, the response of myocardial T2* value to two different pharmacologic interventions.


CONCLUSIONS
The modified technique improved the quality of the images obtained and increased the reliability of myocardial T2* measurements. Using the modified technique, the myocardial T2* value increased significantly over baseline values after the administration of dipyridamole but did not significantly change after the administration of dobutamine. These observations are consistent with the expected response of myocardial venous blood oxygen saturation levels to the infusion of the two pharmacologic agents.
Li
D
D
Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Oellerich
W F
WF
Beck
G
G
Gropler
R J
RJ
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects; D004176:Dipyridamole / Q000494:pharmacology*; D004280:Dobutamine / Q000494:pharmacology*; D005260:Female; D006321:Heart / Q000033:anatomy & histology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010100:Oxygen / Q000097:blood
D004280:Dobutamine; D004176:Dipyridamole; D010100:Oxygen