[Study of mast cell, eosinophil and fibroblast activation in bronchoalveolar lavage fluid in patients with lung cancer].
To assess the role of some pro-inflammatory cells in inflammatory processes in lung cancer by measuring their respective activation markers in different portions of bronchoalveolar lavage (BAL) fluid. Prospective study in a university hospital. We studied 52 BAL samples, 37 from patients with lung cancer and 15 from a control group, using a radioimmunoassay technique to analyze for tryptase (T), hyaluronic acid (HA) and eosinophil cationic protein (ECP) in separate bronchial and bronchoalveolar samples from BAL fluid. Statistical analysis was performed using the R-SIGMA program. Patients with tumors had significantly higher T and HA levels in BAL fluid than did control patients, in both bronchial and bronchoalveolar portions. Lung cancer patients had higher T and ECP levels in bronchoalveolar portions. Mast cells and fibroblasts, at least, play a part in lung cancer, mainly in the distal portions of the bronchial tree.
Márquez Pérez
F L
FL
Sección de Neumología, Hospital Universitario Infanta Cristina, Badajoz.
Blasco Ferrándiz
R
R
Callol Sánchez
L
L
Chivato Pérez
T
T
Villegas Fernández
F
F
Gómez de Terreros Sánchez
F J
FJ
D000230:Adenocarcinoma / Q000175:diagnosis*; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor; D001798:Blood Proteins / Q000032:analysis; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D018287:Carcinoma, Large Cell / Q000175:diagnosis*; D018288:Carcinoma, Small Cell / Q000175:diagnosis*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis*; D053818:Chymases; D047091:Eosinophil Granule Proteins; D004804:Eosinophils; D005260:Female; D005347:Fibroblasts; D006801:Humans; D006820:Hyaluronic Acid / Q000032:analysis; D018836:Inflammation Mediators; D008175:Lung Neoplasms / Q000175:diagnosis*; D008297:Male; D008407:Mast Cells; D008875:Middle Aged; D011446:Prospective Studies; D011863:Radioimmunoassay; D012260:Ribonucleases; D012697:Serine Endopeptidases / Q000032:analysis; D053802:Tryptases
D014408:Biomarkers, Tumor; D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D018836:Inflammation Mediators; D006820:Hyaluronic Acid; D012260:Ribonucleases; D012697:Serine Endopeptidases; C083294:chymase 2; D053818:Chymases; D053802:Tryptases