Effects of fluoxetine administration on mu-opoid receptor immunostaining in the rat forebrain.
Fluoxetine is a selective serotonin reuptake inhibitor. Analysis of mu-opioid receptor immunostaining after chronic fluoxetine administration in rats revealed an increase in the density of cells expressing mu-opioid receptors in the caudatus-putamen, the dentate gyrus, the lateral septum and the frontal, parietal and piriform cortices. These data suggest that mu-opioid receptor expression in the rat forebrain is altered by in vivo chronic fluoxetine treatment.
de Gandarias
J M
JM
Department of Physiology, School of Medicine, University of the Basque Country, PO Box 699, Bilbao, Spain.
Echevarría
E
E
Acebes
I
I
Abecia
L C
LC
Casis
O
O
Casis
L
L
D000818:Animals; D005473:Fluoxetine / Q000494:pharmacology*; D007150:Immunohistochemistry; D008297:Male; D016548:Prosencephalon / Q000737:chemistry / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017450:Receptors, Opioid, mu / Q000032:analysis*; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*
D005473:Fluoxetine; D017450:Receptors, Opioid, mu; D017367:Selective Serotonin Reuptake Inhibitors