Effective treatment of autoimmune diseases with extremely low dose cyclosporine.
The dosage of cyclosporine administered in the treatment of autoimmune diseases has generally been comparable to those required in cases of transplantation. Here we report on the successful treatment using an extremely low dose cyclosporine (1 mg/kg/day) on four patients, involving thrombocytopenia with systemic lupus erythematosus, and interstitial pneumonitis with Sjögren's syndrome, and discuss the optimal dose of cyclosporine for autoimmune-mediated manifestations.
Sugiyama
M
M
Department of Medicine, Juntendo Izu-Nagaoka Hospital.
Sekigawa
I
I
Tokano
Y
Y
Iida
N
N
Hashimoto
H
H
Hirose
S
S
D000328:Adult; D001327:Autoimmune Diseases / Q000188:drug therapy*; D016572:Cyclosporine / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D017563:Lung Diseases, Interstitial / Q000188:drug therapy; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D012859:Sjogren's Syndrome / Q000188:drug therapy; D013921:Thrombocytopenia / Q000188:drug therapy
D007166:Immunosuppressive Agents; D016572:Cyclosporine