[Hepatobiliary clearance of glycocholic acid in Gilbert's disease].
OBJECTIVE
To research the behaviour of one biliary acid (glyco-cholic) i.v. injected in patients with Gilbert's disease and in healthy controls, so that contribute to the knowledge of the pathophysiological correlate between bilirubin and biliary acids.


METHODS
We include 15 patients with Gilbert's disease and 7 healthy voluntary ones. We injected i.v. glycocholic acid and obtained the clearance curve (CG-RIA Abbot method). We evaluated the possible biostatistically significant differences between the obtained values of both groups though the non-parametric method of Mann-Whitney.


RESULTS
The clearance curve of both groups had a similar profile; biostatisticaly there are not significant differences between the serum values of glyco-cholic acid in both groups.


CONCLUSIONS
The clearance of the glyco-cholic acid in patients with Gilbert's disease had a similar behaviour as in healthy controls, without biostatisticaly significant differences between both groups.
Serna Miquel
I
I
Servicio de Medicina Interna (Grupo de Estudio Hepatobiliar), Hospital Clínico y Facultad de Medicina, Universitat de València.
Bataller Sifré
R
R
Bataller Alberola
R
R
Moreno Frígols
J L
JL
D001646:Bile / Q000378:metabolism; D002756:Cholagogues and Choleretics / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005878:Gilbert Disease / Q000378:metabolism*; D006000:Glycocholic Acid / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007275:Injections, Intravenous; D008099:Liver / Q000378:metabolism
D002756:Cholagogues and Choleretics; D006000:Glycocholic Acid