Selected coagulation disorders associated with cancer.
The association between cancer and the increased tendency for bleeding and clotting is well established. Many investigators have reported on the interaction between tumor-related and plasma-related factors that may be responsible for this predisposition in cancer patients. The precise role of any of these factors in thrombosis or bleeding remains speculative. A good understanding of the course of the underlying malignancy, mechanisms of actions of the agents used for treatment, and a high degree of clinical suspicion are required to direct practicing physicians towards an objective and timely diagnosis of these complications. The goal of this article is to provide a broad overview of a few important hemostatic problems encountered in cancer patients.
Sallah
S
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East Carolina University, Division of Hematology/Oncology, Greenville, NC 27858-4354, USA.
D001778:Blood Coagulation Disorders / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D001779:Blood Coagulation Factors / Q000037:antagonists & inhibitors; D004211:Disseminated Intravascular Coagulation / Q000150:complications / Q000503:physiopathology; D005342:Fibrinolysis / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000150:complications* / Q000503:physiopathology; D019851:Thrombophilia / Q000150:complications / Q000503:physiopathology
D001779:Blood Coagulation Factors