Erythropoietin levels can be used to determine tissue oxygenation in critically ill patients.
Critically ill patients often require pharmacological support to maintain blood pressure and cardiac output, and mechanical ventilation to ensure adequate oxygenation. Current methods of measurement of oxygen delivery do not necessarily reflect tissue oxygenation. Levels of circulating erythropoietin reliably reflect the adequacy of renal oxygen supply under physiological and many pathological conditions. It is proposed that the measurement of circulating erythropoietin can be used as a measure of tissue oxygenation in critically ill patients.
Padayatty
S J
SJ
Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
D000818:Animals; D016638:Critical Illness; D004921:Erythropoietin / Q000097:blood* / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption
D004921:Erythropoietin; D010100:Oxygen