Evidence for a second genetic locus in Carney complex.
Carney complex (MIM no. 160980) is an autosomal dominant condition of lentiginosis, cutaneous and cardiac myxomas and multiple endocrine neoplasia. A locus for Carney complex has recently been mapped to chromosome 2p16. We have studied two Northern Irish families with this disorder. Linkage analysis was performed on the families using five highly informative dinucleotide repeat markers covering this area. Negative logarithm of the odds scores were obtained for all markers at all recombination fractions. We conclude that Carney complex is genetically as well as clinically heterogeneous.
Irvine
A D
AD
Department of Medical Genetics, Queen's University Belfast, Belfast City Hospital, Lisburn Road, Belfast BT9 7AB, U.K. airvine.newtbred@dnet.co.uk
Armstrong
D K
DK
Bingham
E A
EA
Hadden
D R
DR
Nevin
N C
NC
Hughes
A E
AE
D001943:Breast Neoplasms / Q000235:genetics*; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D002874:Chromosome Mapping; D004247:DNA; D005260:Female; D006338:Heart Neoplasms / Q000235:genetics*; D006801:Humans; D007911:Lentigo / Q000235:genetics*; D009377:Multiple Endocrine Neoplasia / Q000235:genetics*; D009232:Myxoma / Q000235:genetics*; D010375:Pedigree; D012878:Skin Neoplasms / Q000235:genetics*; D013577:Syndrome
D004247:DNA