Induction of adhesion molecule expression on blood vessels and keratinocytes in recurrent oral ulceration.
Adhesion molecules are known to play a crucial role in the recruitment of inflammatory cells to sites of inflammation. In this study endothelial cell and keratinocyte adhesion molecule expression in recurrent oral ulcers (ROU) (n = 13) was compared with that found in normal oral mucosa (NOM) (n = 11) and experimentally induced ulcers (EIU) (n = 5) by using immunohistochemistry. Significantly greater expression of both vascular cell adhesion molecule- (VCAM-1) and E-selectin was demonstrated on vasculature in ROU compared with that found in both NOM and EIU. Induction of keratinocyte intercellular adhesion molecule-1 (ICAM-1) was also a prominent feature of ROU. The expression of VCAM-1 and E-selectin on blood vessels in ROU is likely to be important in the accumulation of lymphocytes that characterise early aphthous lesions. The induction of keratinocyte ICAM-1 may facilitate lymphocyte invasion of the epithelium in ROU, which may ultimately result in ulcer formation.
Healy
C M
CM
The Department of Oral Medicine and Periodontology, St. Bartholomew's and The Royal London School of Medicine and Dentistry, London, UK.
Thornhill
M H
MH
D000328:Adult; D000911:Antibodies, Monoclonal; D001808:Blood Vessels / Q000378:metabolism; D019040:E-Selectin / Q000032:analysis / Q000235:genetics*; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007150:Immunohistochemistry; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis / Q000235:genetics*; D015603:Keratinocytes / Q000378:metabolism*; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000098:blood supply* / Q000473:pathology; D013281:Stomatitis, Aphthous / Q000235:genetics / Q000378:metabolism*; D019010:Vascular Cell Adhesion Molecule-1 / Q000032:analysis / Q000235:genetics*; D014841:von Willebrand Factor / Q000032:analysis / Q000235:genetics
D000911:Antibodies, Monoclonal; D019040:E-Selectin; D019010:Vascular Cell Adhesion Molecule-1; D014841:von Willebrand Factor; D018799:Intercellular Adhesion Molecule-1