Successful treatment of pemphigus vegetans by addition of etretinate to systemic steroids.
Pemphigus vegetans is a rare variant of pemphigus vulgaris and is characterized by flaccid bullae, which become eroded and form vegetations or papillomatous proliferations, especially in the intertriginous areas. Oral administration of corticosteroids alone does not always induce disease remission in pemphigus vegetans. We report a 44-year-old Japanese man with pemphigus vegetans. Although corticosteroid therapy resulted in healing of the oral ulcers and skin bullae, verrucous vegetations continued to develop. In contrast, by combining corticosteroid with etretinate, verrucous vegetations improved. Thus we propose that the combination therapy of steroid and etretinate might be an effective adjunct in the therapy of pemphigus vegetans.
Ichimiya
M
M
Department of Dermatology, Yamaguchi University School of Medicine, Ube, Japan.
Yamamoto
K
K
Muto
M
M
D000328:Adult; D004359:Drug Therapy, Combination; D005050:Etretinate / Q000627:therapeutic use*; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007641:Keratolytic Agents / Q000627:therapeutic use*; D008297:Male; D010392:Pemphigus / Q000188:drug therapy* / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use*
D005938:Glucocorticoids; D007641:Keratolytic Agents; D005050:Etretinate; D011239:Prednisolone