title: Secretoneurin in carcinoids of the appendix-immunohistochemical comparison with chromogranins A,B and secretogranin II.
abstract: BACKGROUND
  The aim of the present study was to investigate immunohistochemically the distribution of secretoneurin, a novel 33 amino acid peptide, in comparison to chromogranin A, chromogranin B, and secretogranin II in carcinoids of the appendix.
  
  
  METHODS
  Paraffin-embedded tissues from 47 carcinoids were incubated with antibodies specific for chromogranin A, chromogranin B, the secretogranin II derived peptide LF- 19, and secretoneurin.
  
  
  RESULTS
  44 tumors (94%) were positive for secretoneurin, whereas only 39 tumors (83%) were immunoreactive for chromogranin A. There was no significant correlation between neuropeptide expression and type of carcinoid, tumor size, vascular infiltration, serosal involvement or mesoappendiceal infiltration.
  
  
  CONCLUSIONS
  Our investigations revealed that secretoneurin is detected more frequently than chromogranin A in carcinoids of the appendix. This supports the theory that tumor cells of appendiceal carcinoids are of a different origin than other midgut carcinoids. No special tumor entity with a characteristic secretoneurin-chromogranin pattern could be identified.
authors.affiliation: Department of Surgery, University of Innsbruck, Austria. Rupert.Prommegger@uibk.ac.at
authors.forename: R
authors.initials: R
authors.lastname: Prommegger
authors.forename: P
authors.initials: P
authors.lastname: Obrist
authors.forename: C
authors.initials: C
authors.lastname: Ensinger
authors.forename: H G
authors.initials: HG
authors.lastname: Schwelberger
authors.forename: C
authors.initials: C
authors.lastname: Wolf
authors.forename: R
authors.initials: R
authors.lastname: Fischer-Colbrie
authors.forename: G
authors.initials: G
authors.lastname: Mikuz
authors.forename: E
authors.initials: E
authors.lastname: Bodner
mesh_terms: D015703:Antigens, CD; D001063:Appendiceal Neoplasms / Q000473:pathology*; D002276:Carcinoid Tumor / Q000473:pathology*; D053379:Chromogranin A; D002864:Chromogranins / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D009479:Neuropeptides / Q000032:analysis*; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000032:analysis; D011506:Proteins / Q000032:analysis*; D012189:Retrospective Studies; D053381:Secretogranin II
chemical_list: D015703:Antigens, CD; D053379:Chromogranin A; D002864:Chromogranins; D009479:Neuropeptides; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D011506:Proteins; D053381:Secretogranin II; C081159:secretoneurin