[Determining the genetic component of common diseases].
The etiology of many human common diseases is complex and involves a combination of genetic and environmental factors. Genetic factors in most cases are common polymorphisms. Genetic epidemiology, which aim is to identify these factors addresses three sequential questions: Do diseases cluster in families. Is familial clustering related to genetic factors. How is genetic susceptibility inherited. In searching for disease genes, two strategies are possible: Association and/or linkage studies to candidate genes. Whole genome scans.
Feingold
J
J
Unité de Recherches d'Epidémiologie Génétique, INSERM U.155, Université Paris VII, France.
D016000:Cluster Analysis; D004813:Epidemiology; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans