title: The protective role of plasmalogens in iron-induced lipid peroxidation.
abstract: The role of plasmalogens in iron-induced lipid peroxidation was investigated in two liposomal systems. The first consisted of total brain phospholipids with and without plasmalogens, and the second of phosphatidylethanolamine/phosphatidylcholine liposomes with either diacyl- or alkenylacyl-phosphatidylethanolamine. By measuring thiobarbituric acid reactive substances, oxygen consumption, fatty acids and aldehydes, we show that plasmalogens effectively protect polyunsaturated fatty acids from oxidative damage, and that the vinyl ether function of plasmalogens is consumed simultaneously. Furthermore, the lack of lag phase, the increased antioxidant efficiency with time, and the experiments with lipid- and water-soluble azo compounds, indicate that plasmalogens probably interfere with the propagation rather than the initiation of lipid peroxidation, and that the antioxidative effect cannot be related to iron chelation.
authors.affiliation: Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
authors.forename: P J
authors.initials: PJ
authors.lastname: Sindelar
authors.forename: Z
authors.initials: Z
authors.lastname: Guan
authors.forename: G
authors.initials: G
authors.lastname: Dallner
authors.forename: L
authors.initials: L
authors.lastname: Ernster
mesh_terms: D001391:Azo Compounds / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000502:physiology*; D008081:Liposomes; D010101:Oxygen Consumption / Q000502:physiology; D010713:Phosphatidylcholines / Q000378:metabolism; D010714:Phosphatidylethanolamines / Q000378:metabolism; D010955:Plasmalogens / Q000502:physiology*
chemical_list: D001391:Azo Compounds; D008081:Liposomes; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010955:Plasmalogens; D007501:Iron