Eye involvement in the spondyloarthropathies.
Eye inflammation, especially uveitis, is a prominent feature of spondyloarthropathies. Uveitis associated with ankylosing spondylitis and Reiter's syndrome usually is a unilateral acute anterior uveitis with a high tendency to recur sometimes in the contralateral eye. Uveitis associated with undifferentiated spondyloarthropathy, inflammatory bowel disease, and psoriasis may be less characteristic in its presentation, with a higher tendency to posterior pole involvement, bilaterality, and chronicity. Although acute anterior uveitis is grouped into the spectrum of human leukocyte antigen B27-related disease, other genetic and environmental factors including infections by gram-negative bacteria and gut inflammation can play a role in its pathogenesis. The prognosis of uveitis usually is excellent with topical treatment, and only those with posterior pole involvement or a high tendency to recur or to chronicity might benefit from immunosuppressive therapy.
Bañares
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A
Service of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain. chernandez@pulso.com
Hernández-García
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C
Fernández-Gutiérrez
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B
Jover
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JA
D015535:Arthritis, Psoriatic / Q000453:epidemiology; D016918:Arthritis, Reactive / Q000453:epidemiology; D015897:Comorbidity; D006801:Humans; D015994:Incidence; D013167:Spondylitis, Ankylosing / Q000453:epidemiology*; D014605:Uveitis / Q000453:epidemiology*