Mercury-binding capacity of organic and inorganic selenium in rat blood and liver.
The mercury-binding capacity of seleno-DL-methionine and selenium dioxide was assessed in male Wistar rats. Mercury was supplied as fish loaves made of northern pike or rainbow trout. We used a selenium concentration of 3.4 mg/kg fish, about sixfold compared to the equivalent quantity of mercury. Seleno-DL-methionine had a tendency to increase both methyl mercury and total mercury in blood, although it also seemed to reduce the proportion of methyl mercury of total mercury. Selenium dioxide lowered mercury levels by 24-29% both in the blood and in the liver of rats that were fed with northern pike.
Seppänen
K
K
Department of Chemistry, University of Kuopio, Finland.
Laatikainen
R
R
Salonen
J T
JT
Kantola
M
M
Lötjönen
S
S
Harri
M
M
Nurminen
L
L
Kaikkonen
J
J
Nyyssönen
K
K
D000818:Animals; D002149:Energy Intake; D005399:Fishes; D008658:Inactivation, Metabolic; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008628:Mercury / Q000097:blood / Q000378:metabolism* / Q000493:pharmacokinetics*; D008767:Methylmercury Compounds / Q000032:analysis / Q000097:blood / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology*
D008767:Methylmercury Compounds; D008628:Mercury; D012643:Selenium