title: Lymphomatoid granulomatosis of the lung: a clinico-pathological study.
abstract: Lymphomatoid granulomatosis is the only form of pulmonary angiitis histologically characterized by a necrotizing angiocentric and angiodestructive lymphoid infiltrate, with an admixed T-cell reaction. We evaluated three patients with a single lung nodule not diagnosed by routine radiological and endoscopic assays. Our investigations showed a prevalence of T-cells in areas of diffuse infiltration, which were actively replacing reactive follicular areas of B-cells, similarly to T-cell lymphomas. Further pathologic assays suggested the histologic diagnosis of grade I lymphomatoid granulomatosis for all three evaluated specimens. After two years, patients treated with a combination of surgical resection and chemotherapy were disease free, supporting the efficacy of aggressive therapy in the management of this often mistreated group of lymphoid proliferations.
authors.affiliation: Università Campus Bio-Medico, Roma, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Baldi
authors.forename: A M
authors.initials: AM
authors.lastname: Groeger
authors.forename: V
authors.initials: V
authors.lastname: Esposito
authors.forename: E
authors.initials: E
authors.lastname: Di Lieto
authors.forename: M P
authors.initials: MP
authors.lastname: Di Marino
authors.forename: D
authors.initials: D
authors.lastname: Santini
authors.forename: F
authors.initials: F
authors.lastname: Baldi
mesh_terms: D015703:Antigens, CD / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000627:therapeutic use; D018572:Disease-Free Survival; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology / Q000473:pathology; D008230:Lymphomatoid Granulomatosis / Q000188:drug therapy / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology; D013997:Time Factors
chemical_list: D015703:Antigens, CD; D002945:Cisplatin