title: Age-related shift in brain region activity during successful memory performance.
abstract: Coregistered positron emission tomography (PET)/magnetic resonance imaging (MRI) was used to characterize brain function in 70 volunteers, aged 20-87 years, during a verbal memory task. Frontal activity showed an age-related decline that remained significant after statistical control for sulcal atrophy. Analyses of young and old subgroups matched for memory scores revealed that young good performers activated frontal regions, whereas old good performers relied on occipital regions. Although activating different cortical regions, good performers of all ages used the same cognitive strategy semantic clustering. Age-related functional change may reflect dynamic re-allocation in a network of brain areas, not merely anatomically fixed neuronal loss or diminished capacity to perform.
authors.affiliation: Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029-6574, USA. hazlett@msvax.mssm.edu
authors.forename: E A
authors.initials: EA
authors.lastname: Hazlett
authors.forename: M S
authors.initials: MS
authors.lastname: Buchsbaum
authors.forename: R C
authors.initials: RC
authors.lastname: Mohs
authors.forename: J
authors.initials: J
authors.lastname: Spiegel-Cohen
authors.forename: T C
authors.initials: TC
authors.lastname: Wei
authors.forename: R
authors.initials: R
authors.lastname: Azueta
authors.forename: M M
authors.initials: MM
authors.lastname: Haznedar
authors.forename: M B
authors.initials: MB
authors.lastname: Singer
authors.forename: L
authors.initials: L
authors.lastname: Shihabuddin
authors.forename: C
authors.initials: C
authors.lastname: Luu-Hsia
authors.forename: P D
authors.initials: PD
authors.lastname: Harvey
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000378:metabolism; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D008875:Middle Aged; D014055:Tomography, Emission-Computed; D014706:Verbal Learning / Q000502:physiology
chemical_list: D005947:Glucose