[Comparative study of propofol emulsions for anesthesia in varicose vein operations].
OBJECTIVE
It is commonly known that propofol-based anaesthesia is easily controlled and well tolerated. These advantages of propofol are partly offset by the comparably high costs of the anaesthetic. The present prospective randomised double-blind cross-over study compared two propofol emulsions with regard to their efficacy and drug safety.


METHODS
30 patients were included in this study. All patients underwent two propofol-based anaesthesias for leg vein surgery on both legs within 2-4 days. The patients were randomised in two treatment groups where Group A (n = 15) received the investigational drug for the 2nd anaesthesia and the control drug for the 1st anaesthesia. The order of drug application was reversed for Group B (n = 15). The propofol induction doses, the maintenance doses, and the side effect profiles were evaluated for the purpose of comparing the two propofol emulsions.


RESULTS
The study showed no differences in the efficacy of the two propofol emulsions. Furthermore, the side effect profiles were almost identical and did not reveal any unknown side effects of propofol.


CONCLUSIONS
The results clearly demonstrate that both propofol emulsions are comparably well suited for vascular surgery anaesthesia. This study demonstrates a methodological clinical approach to compare the same medication supplied by different manufacturers.
Stroschneider
E
E
Institut für Anästhesiologie, KH Natters.
Margreiter
J
J
Pfeiffer
K P
KP
Eggenreich
U
U
Balogh
D
D
D000328:Adult; D000771:Anesthesia, Intravenous; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000009:adverse effects; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004655:Emulsions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects; D014648:Varicose Veins / Q000601:surgery*
D018686:Anesthetics, Intravenous; D004655:Emulsions; D015742:Propofol