Sensitivity to CCK-4 in women with and without premenstrual dysphoric disorder (PMDD) during their follicular and luteal phases.
The authors determined whether women with premenstrual dysphoric disorder (PMDD) exhibit a heightened sensitivity to the panicogenic effects of CCK-4 administration and whether this enhanced sensitivity to CCK-4 would vary with the phase of the menstrual cycle at the time of CCK-4 injection. Twenty-one normal controls and 18 PMDD women were randomly assigned to receive the first and second CCK-4 injection during the follicular phase and the luteal phase or vice versa. PMDD women showed a greater anxiety and panic response to CCK-4. These preliminary results suggest that the CCK-B system may play a role in the pathophysiology of PMDD.
Le Mellédo
J M
JM
Clarke Institute of Psychiatry, University of Montreal, Quebec, Canada.
Merani
S
S
Koszycki
D
D
Bellavance
F
F
Palmour
R
R
Gutkowska
J
J
Steinberg
S
S
Bichet
D G
DG
Bradwejn
J
J
D000328:Adult; D001007:Anxiety / Q000139:chemically induced; D018592:Cross-Over Studies; D005260:Female; D005498:Follicular Phase; D006728:Hormones / Q000378:metabolism; D006801:Humans; D008183:Luteal Phase; D010200:Panic; D011293:Premenstrual Syndrome / Q000503:physiopathology*; D013758:Tetragastrin / Q000009:adverse effects / Q000494:pharmacology*
D006728:Hormones; D013758:Tetragastrin