title: Relative radiosensitivity of bone tumor induction among beagles as a function of age at injection of 239Pu or 226Ra.
abstract: A comparison was made of the response to induction of skeletal malignancy from exposure of beagles to monomeric 239Pu or to 226Ra as juveniles (3 mo of age), young adults (1.5 y of age), or mature adults (5 y of age). This indicated that of these age groups, animals injected as young adults are most sensitive per Gy of average skeletal dose evaluated at 1 y before death. Dogs exposed either as juveniles or as mature adults appeared to be less sensitive. Relative radiosensitivities (RRS) of juvenile and mature beagles ranged between about 0.3 and 0.7 that of dogs injected as young adults. Mean values of RRS for both radionuclides were about 0.5, but RRS values derived from dogs given monomeric 239Pu appeared to be most reliable and were 0.27+/-0.09 for dogs injected as juveniles and 0.41+/-0.13 for animals exposed as mature adults.
authors.affiliation: University of Utah, Radiobiology Laboratory, Salt Lake City 84112-5860, USA.
authors.forename: R D
authors.initials: RD
authors.lastname: Lloyd
authors.forename: G N
authors.initials: GN
authors.lastname: Taylor
authors.forename: W S
authors.initials: WS
authors.lastname: Jee
authors.forename: S C
authors.initials: SC
authors.lastname: Miller
mesh_terms: D000367:Age Factors; D000818:Animals; D001859:Bone Neoplasms / Q000209:etiology / Q000503:physiopathology*; D004285:Dogs; D004307:Dose-Response Relationship, Radiation; D009381:Neoplasms, Radiation-Induced / Q000503:physiopathology*; D011005:Plutonium; D011883:Radium
chemical_list: D011005:Plutonium; D011883:Radium