title: Biochemical markers of bone metabolism in draught and warmblood horses.
abstract: Concentrations of the cross-linked carboxyterminal telopeptide of type I collagen (ICTP) and osteocalcin (OC) have been determined in the serum of one hundred clinically healthy adult Draught or Warmblood horses. The correlation between these two markers has been evaluated and the influence of gender, age and type of horse described. No significant variations were observed between animals of different sex, but a significant inverse correlation (P < 0.0001) with age was observed for both measured parameters. After correction for age, serum levels of OC were found to be lower in Draught [adjusted least square mean (LSM) = 6.612 micrograms.L-1] than in Warmblood horses (adjusted LSM = 8.596 micrograms.L-1), whereas levels of ICTP were higher in Draughts (adjusted LSM = 8.035 micrograms.L-1) than in Warmbloods (adjusted LSM = 6.643 micrograms.L-1). A significant correlation (P < 0.0001) was observed between OC and ICTP. This correlation was stronger if the type of horse was taken into account in the statistical model. The ratio OC:ICTP was independent of gender and age. A higher OC:ICTP ratio in Warmbloods compared to the Draught horses might reflect a higher bone remodelling level of horses submitted to regular daily work. It was concluded that ICTP and OC are influenced by the type of horse, and probably reflect a physiological difference in bone remodelling between these animals.
authors.affiliation: Clinic for Farm Animals and Horses, School of Veterinary Medicine, University of Berne, Switzerland.
authors.forename: O M
authors.initials: OM
authors.lastname: Lepage
authors.forename: D J
authors.initials: DJ
authors.lastname: Hartmann
authors.forename: R
authors.initials: R
authors.lastname: Eicher
authors.forename: B
authors.initials: B
authors.lastname: Uebelhart
authors.forename: P
authors.initials: P
authors.lastname: Tschudi
authors.forename: D
authors.initials: D
authors.lastname: Uebelhart
mesh_terms: D000367:Age Factors; D000818:Animals; D015415:Biomarkers / Q000097:blood; D016723:Bone Remodeling; D001862:Bone Resorption / Q000097:blood; D003094:Collagen / Q000097:blood*; D024042:Collagen Type I; D005260:Female; D006736:Horses / Q000097:blood*; D008297:Male; D015675:Osteocalcin / Q000097:blood*; D010012:Osteogenesis; D010455:Peptides / Q000097:blood*; D012727:Sex Characteristics
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin; D003094:Collagen