title: Evaluating cervical neoplasia. LEEP as an alternative to cold knife conization.
abstract: OBJECTIVE
  To determine how the loop electrosurgical excision procedure (LEEP) compares to cold knife conization in providing an adequate diagnostic specimen.
  
  
  METHODS
  Between 1991 and 1995, 95 patients underwent either diagnostic LEEP or cold knife conization at Allegheny University Hospitals. The indications for the procedure were a cytologic/histologic discrepancy, unsatisfactory colposcopic evaluation, positive endocervical curettage or exclusion of invasion.
  
  
  RESULTS
  Severe thermal artifact rendered the LEEP specimens uninterpretable in 4.4% of cases. A median number of two passes were required for LEEP excision of the transformation zone. The number of passes correlated with the amount of thermal artifact detected (P = .034). Regarding recurrence patterns, normal follow-up cervical cytology was similar for both groups: 96.7% in the LEEP group vs. 100% in the cold knife conization group.
  
  
  CONCLUSIONS
  We conclude that LEEP is an acceptable diagnostic alternative to traditional cold knife conization. Thermal artifact remains a disadvantage that can be minimized by limiting the number of passes required to obtain a complete specimen.
authors.affiliation: Department of Obstetrics and Gynecology, Medical College of Pennsylvania-Hahnemann School of Medicine, Allegheny University of the Health Sciences, Philadelphia, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Simmons
authors.forename: L
authors.initials: L
authors.lastname: Anderson
authors.forename: E
authors.initials: E
authors.lastname: Hernandez
authors.forename: P B
authors.initials: PB
authors.lastname: Heller
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D019092:Conization / Q000379:methods*; D004598:Electrosurgery / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007431:Intraoperative Complications; D008499:Medical Records; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D012189:Retrospective Studies; D013048:Specimen Handling; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000473:pathology