[Multiple role of hedgehog genes in vertebrates: data from analysis of mutations].
Hedgehog (hh) gene has been discovered in Drosophila as result of the now famous screen for embryonic mutants in Drosophila performed by Dr. Christianne Nusslein-Volhard and her Ph.D. student Eric Wieschaus in 1980 in Tubingen, Germany (Nusslein-Volhard and Wieschaus, 1980). Due to recognition of the impact of these mutants onto contemporary developmental biology these scientists obtained a Nobel Prize in 1995. By that time it become obvious that the history of hh studies represents one of the most interesting chapters of developmental biology.
Korzh
V P
VP
Institute of Molecular Agrobiology, Singapore.
D000818:Animals; D005075:Biological Evolution; D019521:Body Patterning / Q000235:genetics*; D004330:Drosophila / Q000196:embryology / Q000235:genetics*; D004627:Embryonic Induction / Q000235:genetics; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D017344:Genes, Insect; D005804:Genes, Lethal; D009154:Mutation; D014714:Vertebrates / Q000196:embryology / Q000235:genetics*