CD1d-restricted immunoglobulin G formation to GPI-anchored antigens mediated by NKT cells.
Immunoglobulin G (IgG) responses require major histocompatibility complex (MHC)-restricted recognition of peptide fragments by conventional CD4(+) helper T cells. Immunoglobulin G responses to glycosylphosphatidylinositol (GPI)- anchored protein antigens, however, were found to be regulated in part through CD1d-restricted recognition of the GPI moiety by thymus-dependent, interleukin-4-producing CD4(+), natural killer cell antigen 1.1 [(NK1.1)+] helper T cells. The CD1-NKT cell pathway regulated immunogobulin G responses to the GPI-anchored surface antigens of Plasmodium and Trypanosoma and may be a general mechanism for rapid, MHC-unrestricted antibody responses to diverse pathogens.
Schofield
L
L
Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia. schofield@wehi.edu.au
McConville
M J
MJ
Hansen
D
D
Campbell
A S
AS
Fraser-Reid
B
B
Grusby
M J
MJ
Tachado
S D
SD
D000818:Animals; D017951:Antigen Presentation; D000938:Antigen-Presenting Cells / Q000276:immunology; D000941:Antigens / Q000032:analysis; D018949:Antigens, CD1 / Q000276:immunology*; D000950:Antigens, Ly; D000953:Antigens, Protozoan / Q000276:immunology*; D000954:Antigens, Surface; D002478:Cells, Cultured; D017261:Glycosylphosphatidylinositols / Q000276:immunology*; D007074:Immunoglobulin G / Q000096:biosynthesis*; D015847:Interleukin-4 / Q000096:biosynthesis; D037181:Lectins, C-Type; D007894:Leishmania mexicana / Q000276:immunology; D008285:Major Histocompatibility Complex; D051379:Mice; D008815:Mice, Inbred Strains; D055651:NK Cell Lectin-Like Receptor Subfamily B; D010961:Plasmodium / Q000276:immunology; D011506:Proteins / Q000032:analysis; D015800:Protozoan Proteins / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D014346:Trypanosoma brucei brucei / Q000276:immunology; D014643:Variant Surface Glycoproteins, Trypanosoma / Q000276:immunology
D000941:Antigens; D018949:Antigens, CD1; D000950:Antigens, Ly; D000953:Antigens, Protozoan; D000954:Antigens, Surface; D017261:Glycosylphosphatidylinositols; D007074:Immunoglobulin G; C527211:Klrb1c protein, mouse; D037181:Lectins, C-Type; D055651:NK Cell Lectin-Like Receptor Subfamily B; D011506:Proteins; D015800:Protozoan Proteins; D014643:Variant Surface Glycoproteins, Trypanosoma; C041595:circumsporozoite protein, Protozoan; D015847:Interleukin-4