title: Nasal secretion analysis in allergic rhinitis, cystic fibrosis, and nonallergic fibromyalgia/chronic fatigue syndrome subjects.
abstract: Rhinitis symptoms are present in approximately 70% of subjects with fibromyalgia and chronic fatigue syndrome (FM/CFS). Because only 35% to 50% have positive allergy skin tests, nonallergic mechanisms may also play a role. To better understand the mechanisms of nonallergic rhinitis in FM/CFS, nasal lavages were performed, and markers of vascular permeability, glandular secretion, and neutrophil and eosinophil infiltration measured in 27 nonallergic FM/CFS, 7 allergic rhinitis, 7 cystic fibrosis, and 9 normal subjects. Allergic rhinitis subjects had significantly increased vascular permeability (IgG) and ECP levels. Cystic fibrosis subjects had significantly higher elastase and total protein levels. There were no significant differences between FM/CFS and normal lavage fluids. Analysis of the constituents of nasal mucus provides information about ongoing secretory processes in rhinitis. There were no differences in the basal secretion of these markers of vascular permeability, submucosal gland serous cell secretion, eosinophil and neutrophil degranulation in nonallergic FM/CFS subjects. This suggests that constitutively active secretory processes that regulate continuous production of nasal secretions are not altered in FM/CFS. Future studies should examine alternative mechanisms such as inducible, irritant-activated, or reflex-mediated effects.
authors.affiliation: Division of Rheumatology and Immunology and Allergy, Georgetown University, Washington, D.C. 20007-2197, USA.
authors.forename: J N
authors.initials: JN
authors.lastname: Baraniuk
authors.forename: D
authors.initials: D
authors.lastname: Clauw
authors.forename: A
authors.initials: A
authors.lastname: Yuta
authors.forename: M
authors.initials: M
authors.lastname: Ali
authors.forename: E
authors.initials: E
authors.lastname: Gaumond
authors.forename: N
authors.initials: N
authors.lastname: Upadhyayula
authors.forename: K
authors.initials: K
authors.lastname: Fujita
authors.forename: T
authors.initials: T
authors.lastname: Shimizu
mesh_terms: D000328:Adult; D001798:Blood Proteins / Q000032:analysis; D002199:Capillary Permeability; D003550:Cystic Fibrosis / Q000378:metabolism* / Q000503:physiopathology; D047091:Eosinophil Granule Proteins; D015673:Fatigue Syndrome, Chronic / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D005356:Fibromyalgia / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D018836:Inflammation Mediators / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009113:Muramidase / Q000032:analysis; D017817:Nasal Lavage Fluid / Q000737:chemistry*; D009297:Nasal Mucosa / Q000098:blood supply / Q000378:metabolism; D010196:Pancreatic Elastase / Q000032:analysis; D011506:Proteins / Q000032:analysis; D012221:Rhinitis, Allergic, Perennial / Q000378:metabolism* / Q000503:physiopathology; D006255:Rhinitis, Allergic, Seasonal / Q000378:metabolism* / Q000503:physiopathology; D012260:Ribonucleases
chemical_list: D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D007074:Immunoglobulin G; D018836:Inflammation Mediators; D011506:Proteins; D012260:Ribonucleases; D009113:Muramidase; D010196:Pancreatic Elastase