Characterization of Fe(III)-deferoxamine and Mn(II)-pectin as magnetic resonance imaging contrast agents.
To find new contrast agents for magnetic resonance imaging (MRI), the spin-lattice relaxation time (T1)-reducing activities of metal complexes of EDTA, N-hydroxyethyethylenediamine-N,N',N'-triacetic acid (HEDTA), diethylenetriamine-N,N,N',N'',N''-pentaacetic acid (DTPA), deferoxamine, mugineic acid, and pectin with Fe(III) or Mn(II) were investigated. Strong activity was found in Fe(III)-deferoxamine, Fe(III)-mugineic acid, or Mn(II)-pectin. In the actual MRI tomogram, Fe(III)-deferoxamine exhibited a contrast-enhancing effect comparable with that of Gd(III)-DTPA, and a much stronger effect was observed for Mn(II)-pectin. Fe(III)-deferoxamine and the Mn(II)-pectin appear to be candidates, respectively, as a new intravenous contrast agent and an oral gastrointestinal one.
Mino
Y
Y
Department of Pharmacognosy, Osaka University of Pharmaceutical Sciences, Takatsuki, Japan.
Kitagaki
H
H
Sasaki
M
M
Ishii
K
K
Mori
T
T
Yamada
K
K
Nagasawa
O
O
D002614:Chelating Agents / Q000737:chemistry; D003287:Contrast Media / Q000737:chemistry*; D003676:Deferoxamine / Q000031:analogs & derivatives / Q000737:chemistry*; D004492:Edetic Acid / Q000031:analogs & derivatives / Q000737:chemistry; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010368:Pectins / Q000737:chemistry*; D004369:Pentetic Acid / Q000737:chemistry
D002614:Chelating Agents; D003287:Contrast Media; D004369:Pentetic Acid; D010368:Pectins; D004492:Edetic Acid; D003676:Deferoxamine; C026060:N-(hydroxyethyl)ethylenediaminetriacetic acid