[The influence of RS-Timolol in comparison with R-Timolol and S-Timolol on the intraocular pressure in water-loaded rabbits].
OBJECTIVE
It is assumed that S-timolol can produce more severe systemic adverse reactions than R-timolol. The aim of this study was to estimate the intraocular pressure-lowering effect of RS-timolol in comparison to R-timolol and S-timolol in water-loaded rabbits.


METHODS
Ocular hypertension was provoked in rabbits by orogastric water loading. Topical administration of one of three timolol solutions: 0.85%, RS-timolol, or 3% R-timolol, or 0.5% S-timolol was performed to the right eyes 40 min before starting the water loading procedure. Left eyes served as a control group. Intraocular pressure was measured before and 30, 60, 90, 120 min after the water loading.


RESULTS
Intraocular pressure-lowering effect of all three timolol solutions was comparable.


CONCLUSIONS
RS-timolol can be effective for lowering intraocular pressure in rabbits.
Czechowicz-Janicka
K
K
Kliniki Okulistyki Centrum Medycznego Kształcenia Podyplomowego w Warszawie.
Kamińska
E
E
Staszkiewicz
J
J
Terelak-Borys
B
B
Oledzka
K
K
Danysz
A
A
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D007429:Intraocular Pressure / Q000187:drug effects*; D011817:Rabbits; D013997:Time Factors; D013999:Timolol / Q000494:pharmacology*
D000319:Adrenergic beta-Antagonists; D013999:Timolol