The inhibitory effects of the fluoroquinolone antimicrobials norfloxacin and enrofloxacin on hepatic microsomal cytochrome P-450 monooxygenases in broiler chickens.
The fluoroquinolone antimicrobials norfloxacin and enrofloxacin were found to inhibit hepatic microsomal cytochrome P-450 monooxygenases in the livers of broiler chickens using dosages as given in commercial flocks. Norfloxacin inhibited the process of N-demethylation of aminopyrine to a greater degree, while enrofloxacin more markedly inhibited hydroxylation of aniline.
Shlosberg
A
A
Kimron Veterinary Institute, Bet Dagan, Israel.
Ershov
E
E
Bellaiche
M
M
Hanji
V
V
Weisman
Y
Y
Soback
S
S
D000633:Aminopyrine N-Demethylase / Q000187:drug effects / Q000378:metabolism; D000815:Aniline Hydroxylase / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002645:Chickens / Q000378:metabolism*; D065607:Cytochrome P-450 Enzyme Inhibitors; D000077422:Enrofloxacin; D024841:Fluoroquinolones; D008099:Liver / Q000033:anatomy & histology; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D009643:Norfloxacin / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D015363:Quinolones / Q000494:pharmacology*
D000890:Anti-Infective Agents; D065607:Cytochrome P-450 Enzyme Inhibitors; D024841:Fluoroquinolones; D015363:Quinolones; D000077422:Enrofloxacin; D000815:Aniline Hydroxylase; D000633:Aminopyrine N-Demethylase; D009643:Norfloxacin