Conversion of chylomicrons into remnants.
The turnover of chylomicrons in the blood is the sum of several processes. The native chylomicron is synthesized in the intestine out of available substrates. When the chylomicron enters the circulation exchanges of apolipoproteins with other lipoproteins, it also binds to the vascular endothelium where the chylomicron is lipolyzed by lipoprotein lipase. After a short period in the circulation the chylomicron/chylomicron remnant appears to be available for receptor mediated uptake. In this paper several of the processes involved in generation and clearance of chylomicron remnants are discussed.
Hultin
M
M
Department of Medical Biochemistry and Biophysics, Umeå University, Sweden. magnus.hultin@medchem.umu.se
Olivecrona
T
T
D000818:Animals; D001161:Arteriosclerosis / Q000378:metabolism; D002914:Chylomicrons / Q000097:blood*; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D008066:Lipolysis; D018110:Receptors, Lipoprotein / Q000378:metabolism*
D002914:Chylomicrons; D018110:Receptors, Lipoprotein; C028203:chylomicron receptor