title: Hierridin B and 2,4-dimethoxy-6-heptadecyl-phenol, secondary metabolites from the cyanobacterium Phormidium ectocarpi with antiplasmodial activity.
abstract: Bioassay guided fractionation of the lipophilic extract of the marine cyanobacterium Phormidium ectocarpi yielded a new natural product hierridin B and the previously described compound 2,4-dimethoxy-6-heptadecyl-phenol. Both structures were secured by extensive spectroscopic analysis (1D and 2D NMR, MS, GC-MS, IR). The isolate (mixture) showed antiplasmodial activity towards Plasmodium falciparum.
authors.affiliation: Institute for Pharmaceutical Biology, Technical University of Braunschweig, Germany.
authors.forename: O
authors.initials: O
authors.lastname: Papendorf
authors.forename: G M
authors.initials: GM
authors.lastname: König
authors.forename: A D
authors.initials: AD
authors.lastname: Wright
mesh_terms: D000473:Alkanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000840:Anisoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000962:Antimalarials / Q000302:isolation & purification* / Q000494:pharmacology; D000458:Cyanobacteria / Q000737:chemistry*; D015394:Molecular Structure; D019800:Phenol / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013057:Spectrum Analysis
chemical_list: C113325:2,4-dimethoxy-6-heptadecylphenol; D000473:Alkanes; D000840:Anisoles; D000962:Antimalarials; C116944:hierridin B; D019800:Phenol