title: Morphometrical and immunopathological dissection of the hepatic Schistosoma haematobium granuloma in the murine host.
abstract: This paper presents the results of a study aimed at identifying the immunopathological and morphometrical characteristics of liver granulomas induced by the parasite Schistosoma haematobium. The OF1 mouse is a susceptible host for experimental infection with the Egyptian NAMRU-3 strain of S. haematobium. Formation of liver granulomas started after 13-14 weeks of infection. These hepatic granulomas reached a maximum volume after 20 weeks of infection (MGV: 1.82 +/- 0.15 x 10(7) micron 3) and regressed thereafter (1.55 +/- 0.16 x 10(7) micron 3 after 24 weeks). Strong cellular upregulation of the adhesion molecules ICAM-1, LFA-1, syndecan-1, VLA-4, but not VLA-6 is seen, both in acute and chronic granulomas. Finally, pathological differences exist between hepatic S. mansoni and S. haematobium granulomas particularly at the level of extracellular matrix deposition. S. haematobium induced peri-ovular deposition of mainly fibronectin and to a lesser extent type I and IV collagen.
authors.affiliation: Department of Pathology, University of Antwerp (UIA), Belgium.
authors.forename: W
authors.initials: W
authors.lastname: Jacobs
authors.forename: K
authors.initials: K
authors.lastname: Van de Vijver
authors.forename: A
authors.initials: A
authors.lastname: Deelder
authors.forename: E
authors.initials: E
authors.lastname: Van Marck
mesh_terms: D000818:Animals; D015815:Cell Adhesion Molecules / Q000032:analysis; D004195:Disease Models, Animal; D016326:Extracellular Matrix Proteins / Q000032:analysis; D006099:Granuloma / Q000276:immunology / Q000473:pathology*; D007150:Immunohistochemistry; D008099:Liver / Q000737:chemistry / Q000469:parasitology / Q000473:pathology; D008109:Liver Diseases, Parasitic / Q000276:immunology / Q000473:pathology*; D008297:Male; D051379:Mice; D012548:Schistosoma haematobium / Q000276:immunology*; D012553:Schistosomiasis haematobia / Q000276:immunology / Q000473:pathology*; D015854:Up-Regulation
chemical_list: D015815:Cell Adhesion Molecules; D016326:Extracellular Matrix Proteins