The pattern of antiganglioside antibody reactivities producing myelinated nerve conduction block in vitro.
We studied the pattern of human antiganglioside antibody reactivities causing an acute conduction block in rat myelinated nerve fibers, using an in vitro preparation of the sciatic-tibial nerve. With the aid of complements, IgM antibodies reacting with the terminal disaccharide of galactose (beta1-3)N-acetylgalactosamine produced the block. These findings may help us to understand the mechanism in which the conduction block occurs in neuropathies associated with antiganglioside antibodies.
Arasaki
K
K
Department of Neurology, NTT Kanto Teishin Hospital, Tokyo, Japan. arasaki@kth.ntt.co.jp
Kusunoki
S
S
Kudo
N
N
Tamaki
M
M
D000200:Action Potentials / Q000502:physiology; D000293:Adolescent; D000328:Adult; D000818:Animals; D000937:Antigen-Antibody Reactions; D003711:Demyelinating Diseases / Q000276:immunology*; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009407:Nerve Block; D009413:Nerve Fibers, Myelinated / Q000276:immunology*; D009431:Neural Conduction / Q000276:immunology*; D011843:Radiculopathy / Q000276:immunology*; D051381:Rats; D017208:Rats, Wistar
D005732:Gangliosides