A sesquiterpene lactone glucoside from Ixeris denticulata f. pinnatipartita.
An extract from the entire Ixeris denticulata f. pinnatipartita plant afforded the guaianolide sesquiterpene lactone glucoside, 8 beta,15-dihydroxy-1(10),3,11(13)-guaiatrien-12,6-olide-15-O- glucopyranoside, along with the known flavonoids luteolin-7-O-glucoside and luteolin-7-O-glucuronide-6'-methyl ester; their structures were determined by spectroscopic methods. Ixerin Y inhibited the growth of human breast cancer MCF7 and MDA468 cell lines.
Ma
J Y
JY
Pharmanex Shanghai R&D Center, Shanghai Medical University, People's Republic China.
Wang
Z T
ZT
Xu
L S
LS
Xu
G J
GJ
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D001943:Breast Neoplasms; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification; D018515:Plant Leaves; D010946:Plants, Medicinal; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D005960:Glucosides; D007783:Lactones; D012717:Sesquiterpenes