title: [Role of surgical interventions in the treatment of patients with trophoblastic tumor resistant to chemotherapy].
abstract: A retrospective evaluation of 85 case histories of chemotherapy-resistant trophoblastic disease treated at the Center's clinic (1975-1996) was carried out. Both therapy efficacy and survival rates were lower in patients operated on prior to chemotherapy and during medication. However, excision of resistant foci of trophoblastic tumor contributed to the effectiveness of chemotherapy.
authors.affiliation: N.N. Blokhin Center for Cancer Research, Russian Academy of Medical Sciences, Moscow.
authors.forename: L A
authors.initials: LA
authors.lastname: Meshcheriakova
authors.forename: V P
authors.initials: VP
authors.lastname: Kozachenko
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003627:Data Interpretation, Statistical; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007044:Hysterectomy; D009362:Neoplasm Metastasis; D011247:Pregnancy; D012189:Retrospective Studies; D013997:Time Factors; D014328:Trophoblastic Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery*; D014594:Uterine Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery*
chemical_list: D000970:Antineoplastic Agents