title: Two domains of the Borna disease virus p40 protein are required for interaction with the p23 protein.
abstract: Borna disease virus (BDV) has five major open reading frames, which encode the proteins p40, p23, gp18, p57 and p190. By analogy with other negative-strand RNA viruses, p40 is a putative nucleoprotein and p23 is a putative phosphoprotein. These proteins are known to form complexes with each other and with the polymerase protein in other viruses. In this paper, it is shown that BDV p40 and p23 can form complexes with each other in infected cells. Furthermore, the amino acids of p40 that are necessary for formation of this complex have been mapped.
authors.affiliation: Department of Veterinary Microbiology, Swedish University of Agricultural Sciences, Uppsala. Mikael.Berg@bmc.uu.se
authors.forename: M
authors.initials: M
authors.lastname: Berg
authors.forename: C
authors.initials: C
authors.lastname: Ehrenborg
authors.forename: J
authors.initials: J
authors.lastname: Blomberg
authors.forename: R
authors.initials: R
authors.lastname: Pipkorn
authors.forename: A L
authors.initials: AL
authors.lastname: Berg
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D001890:Borna Disease / Q000473:pathology / Q000821:virology; D001891:Borna disease virus / Q000378:metabolism*; D002460:Cell Line; D006736:Horses; D008969:Molecular Sequence Data; D010449:Peptide Mapping; D010750:Phosphoproteins / Q000235:genetics / Q000378:metabolism*; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D010750:Phosphoproteins; D011993:Recombinant Fusion Proteins; D014764:Viral Proteins; C084757:p24 protein, Borna disease virus; C077347:p40 protein, Borna disease virus