A proposal for analysing the acid-base balance at steady state in vivo.
[H+] in plasma in vivo is composed of a PCO2-dependent component [H+]* and a PCO2-independent component delta [H+]. The correct equation for the calculation of [H+]* was found by referring to the slope of the regression line between the venous-arterial difference of delta [H+] and that of PCO2. Using [H+]*, the buffer value in vivo and the base excess were calculated. Since the base excess was hyperbolic against delta [H+] and dependent on PCO2, we concluded that it was better to use delta [H+] rather than the base excess to evaluate the metabolic change of [H+] in plasma.
Mochizuki
M
M
Geriatric Respiratory Research Center, Nishimaruyama Hospital, Sapporo, Japan.
D000136:Acid-Base Equilibrium; D000368:Aged; D000369:Aged, 80 and over; D001639:Bicarbonates / Q000097:blood; D001774:Blood Chemical Analysis / Q000379:methods*; D002245:Carbon Dioxide / Q000097:blood*; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure
D001639:Bicarbonates; D006454:Hemoglobins; D002245:Carbon Dioxide; D010100:Oxygen