title: Effects of pentachlorophenol, pentylenetetrazol and carnitine on mitochondria.
abstract: Pentachlorophenol (PCP) increased oxygen consumption and lowered the respiratory control ratio (RCR) in mitochondria from rat liver. These effects of PCP were lessened by 1 mM L-carnitine but not by D-carnitine. In contrast, up to 150 mM of pentylenetetrazol (PTZ) added at state 4 of respiration did not accelerate oxygen consumption. When mitochondria were incubated with 3.3 mM of PTZ, oxygen consumption, RCR and ADP/O ratio were all decreased. Moreover, these could not be suppressed even by high concentrations (-20 mM) of L-carnitine. Thus, while L-carnitine could suppress effects of PCP, it could not counteract PTZ in mitochondria. It appears that anticonvulsive effects of carnitine in PTZ-induced seizures may not be due to mitochondrial protection.
authors.affiliation: Department of Environmental Toxicology, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors.forename: Z
authors.initials: Z
authors.lastname: Yu
authors.forename: Y
authors.initials: Y
authors.lastname: Iryo
authors.forename: M
authors.initials: M
authors.lastname: Matsuoka
authors.forename: H
authors.initials: H
authors.lastname: Igisu
mesh_terms: D000818:Animals; D002331:Carnitine / Q000494:pharmacology*; D003292:Convulsants / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D010416:Pentachlorophenol / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D010433:Pentylenetetrazole / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D003292:Convulsants; D010416:Pentachlorophenol; D002331:Carnitine; D010433:Pentylenetetrazole