title: The inhibitory effects of the fluoroquinolone antimicrobials norfloxacin and enrofloxacin on hepatic microsomal cytochrome P-450 monooxygenases in broiler chickens.
abstract: The fluoroquinolone antimicrobials norfloxacin and enrofloxacin were found to inhibit hepatic microsomal cytochrome P-450 monooxygenases in the livers of broiler chickens using dosages as given in commercial flocks. Norfloxacin inhibited the process of N-demethylation of aminopyrine to a greater degree, while enrofloxacin more markedly inhibited hydroxylation of aniline.
authors.affiliation: Kimron Veterinary Institute, Bet Dagan, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Shlosberg
authors.forename: E
authors.initials: E
authors.lastname: Ershov
authors.forename: M
authors.initials: M
authors.lastname: Bellaiche
authors.forename: V
authors.initials: V
authors.lastname: Hanji
authors.forename: Y
authors.initials: Y
authors.lastname: Weisman
authors.forename: S
authors.initials: S
authors.lastname: Soback
mesh_terms: D000633:Aminopyrine N-Demethylase / Q000187:drug effects / Q000378:metabolism; D000815:Aniline Hydroxylase / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002645:Chickens / Q000378:metabolism*; D065607:Cytochrome P-450 Enzyme Inhibitors; D000077422:Enrofloxacin; D024841:Fluoroquinolones; D008099:Liver / Q000033:anatomy & histology; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D009643:Norfloxacin / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D015363:Quinolones / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D065607:Cytochrome P-450 Enzyme Inhibitors; D024841:Fluoroquinolones; D015363:Quinolones; D000077422:Enrofloxacin; D000815:Aniline Hydroxylase; D000633:Aminopyrine N-Demethylase; D009643:Norfloxacin