title: Gene/longevity association studies at four autosomal loci (REN, THO, PARP, SOD2).
abstract: The possibility that four loci (REN, THO, PARP, SOD2) are associated with longevity was explored by comparing the genotypic pools of subjects older than 100 years with those of younger subjects matched for sex and geographic area (northern and southern Italy). The markers (all located within the respective gene) were HUMREN4; HUMTHO1; HUMPARP (gt)845nt; SOD2(C/T)401nt. In order to reduce the number of genotypes, multiallelic polymorphisms were recoded as diallelic according to allele size and frequency patterns (small: S, and large: L, alleles). A significant loss of LL homozygous genotypes was found at the THO locus in male but not in female centenarians with respect to matched controls. On the other hand no significant difference was found between case/control genotypic frequencies at REN, PARP, SOD2 loci. The latter loci therefore do not affect inter-individual variability in life expectancy (at least in terms of qualitative variants associated with the tested markers). However, the data is consistent with an association between the THO locus and longevity.
authors.affiliation: Cell Biology Department, University of Calabria, Italy. g.debenedictis@unical.it
authors.forename: G
authors.initials: G
authors.lastname: De Benedictis
authors.forename: L
authors.initials: L
authors.lastname: Carotenuto
authors.forename: G
authors.initials: G
authors.lastname: Carrieri
authors.forename: M
authors.initials: M
authors.lastname: De Luca
authors.forename: E
authors.initials: E
authors.lastname: Falcone
authors.forename: G
authors.initials: G
authors.lastname: Rose
authors.forename: S
authors.initials: S
authors.lastname: Cavalcanti
authors.forename: F
authors.initials: F
authors.lastname: Corsonello
authors.forename: E
authors.initials: E
authors.lastname: Feraco
authors.forename: G
authors.initials: G
authors.lastname: Baggio
authors.forename: S
authors.initials: S
authors.lastname: Bertolini
authors.forename: D
authors.initials: D
authors.lastname: Mari
authors.forename: R
authors.initials: R
authors.lastname: Mattace
authors.forename: A I
authors.initials: AI
authors.lastname: Yashin
authors.forename: M
authors.initials: M
authors.lastname: Bonafè
authors.forename: C
authors.initials: C
authors.lastname: Franceschi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002874:Chromosome Mapping; D005260:Female; D006801:Humans; D008136:Longevity / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011065:Poly(ADP-ribose) Polymerases / Q000235:genetics*; D012083:Renin / Q000235:genetics*; D013482:Superoxide Dismutase / Q000235:genetics*; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics*
chemical_list: D014446:Tyrosine 3-Monooxygenase; D013482:Superoxide Dismutase; D011065:Poly(ADP-ribose) Polymerases; D012083:Renin