The application of capillary gas chromatography-selective ion mass spectrometry for the separation, identification and quantification of phenolic bupivacaine metabolites from human urine.
A capillary gas chromatographic method has been developed and validated for the separation of phenolic metabolites from human urine following the intravenous infusion of racemic bupivacaine, with subsequent formal identification and quantification by on-line mass spectrometry.
Zhang
A Q
AQ
Division of Biomedical Sciences, Imperial College School of Medicine, London, UK.
Mitchell
S C
SC
Caldwell
J
J
D002045:Bupivacaine / Q000031:analogs & derivatives / Q000032:analysis / Q000378:metabolism* / Q000652:urine; D002623:Chemistry Techniques, Analytical / Q000379:methods*; D019075:Electrophoresis, Capillary; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D017736:Ion-Selective Electrodes; D008297:Male; D010636:Phenols / Q000032:analysis*
D010636:Phenols; C051879:4'-hydroxybupivacaine; D002045:Bupivacaine