title: Craniofacial resection for malignant neoplasms of the skull base: an overview.
abstract: Advances in combined transcranial and transfacial (craniofacial) approaches for malignant tumors involving the anterior skull base have demonstrated improved survival. The technique allows adequate assessment of the intracranial extent of the tumor through an appropriate craniotomy. Vital structures, such as the dura, brain, and blood vessels, can be protected or resected and reconstructed safely. An en bloc excision can be accomplished. Dural defects and/or tears are satisfactorily repaired under direct vision, ensuring a watertight closure. Finally, adequate closure of the soft tissue defect is obtained, thus segregating the cranial cavity from the potentially infected nasal cavity and the nasopharynx with a resultant decrease in morbidity. Operative mortality is low, although complication rates are high. The technique is safe and continues to be improved to reduce morbidity. To evaluate the true impact of this surgical procedure on improvement in survival as well as quality of life, a multiinstitutional registry with uniform indications is indicated. With increasing experience and well-defined indications, improvement in survival (from 50% to 60%) and reduction in morbidity (from 30% to 40%) can be demonstrated through multiinstitutional, cooperative efforts.
authors.affiliation: Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
authors.forename: J O
authors.initials: JO
authors.lastname: Boyle
authors.forename: K C
authors.initials: KC
authors.lastname: Shah
authors.forename: J P
authors.initials: JP
authors.lastname: Shah
mesh_terms: D003399:Craniotomy / Q000379:methods*; D005147:Facial Bones / Q000601:surgery*; D006801:Humans; D011183:Postoperative Complications / Q000453:epidemiology; D011379:Prognosis; D019651:Plastic Surgery Procedures / Q000379:methods; D019291:Skull Base / Q000033:anatomy & histology; D019292:Skull Base Neoplasms / Q000401:mortality / Q000601:surgery*; D016019:Survival Analysis; D016896:Treatment Outcome