title: Intracellular magnesium predicts functional capacity in patients with coronary artery disease.
abstract: To determine whether increased intracellular levels of magnesium ([Mg]i) are associated with enhanced functional capacity, we performed symptom-limited exercise treadmill testing on 42 stable coronary artery disease (CAD) patients (37 men, 5 women, mean age 68 +/- 9 years). [Mg]i was found to be an independent and significant predictor of exercise duration (R = 0.31, p = 0.02) in a multivariate stepwise regression model. Patients with > normal [Mg]i of 1.23 microg/mg protein (n = 13) had a significantly greater mean functional capacity, measured in higher achieved metabolic equivalents (10.6 +/- 2.5 vs. 8.9 +/- 2.3, p < 0.05) and exercise duration (9.4 +/- 2.3 vs. 7.9 +/- 2.2 min, p < 0.05) compared to patients with [Mg]i </= the normal (n = 29). Thus, functional capacity is greater in stable CAD patients with higher [Mg]i, suggesting that magnesium may play a role in CAD pathophysiology, possibly via ventricular unloading.
authors.affiliation: Division of Cardiology, Department of Medicine, Preventive and Rehabilitative Cardiac Center, Cedars-Sinai Medical Center and UCLA School of Medicine, Los Angeles, Calif., USA.shechterm@csmc.edu
authors.forename: M
authors.initials: M
authors.lastname: Shechter
authors.forename: M J
authors.initials: MJ
authors.lastname: Paul-Labrador
authors.forename: R K
authors.initials: RK
authors.lastname: Rude
authors.forename: C N
authors.initials: CN
authors.lastname: Bairey Merz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003327:Coronary Disease / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology*; D005080:Exercise Test; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007424:Intracellular Fluid / Q000378:metabolism*; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008274:Magnesium / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011379:Prognosis; D011446:Prospective Studies; D014938:Work Capacity Evaluation
chemical_list: D008274:Magnesium