title: The pattern of antiganglioside antibody reactivities producing myelinated nerve conduction block in vitro.
abstract: We studied the pattern of human antiganglioside antibody reactivities causing an acute conduction block in rat myelinated nerve fibers, using an in vitro preparation of the sciatic-tibial nerve. With the aid of complements, IgM antibodies reacting with the terminal disaccharide of galactose (beta1-3)N-acetylgalactosamine produced the block. These findings may help us to understand the mechanism in which the conduction block occurs in neuropathies associated with antiganglioside antibodies.
authors.affiliation: Department of Neurology, NTT Kanto Teishin Hospital, Tokyo, Japan. arasaki@kth.ntt.co.jp
authors.forename: K
authors.initials: K
authors.lastname: Arasaki
authors.forename: S
authors.initials: S
authors.lastname: Kusunoki
authors.forename: N
authors.initials: N
authors.lastname: Kudo
authors.forename: M
authors.initials: M
authors.lastname: Tamaki
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000293:Adolescent; D000328:Adult; D000818:Animals; D000937:Antigen-Antibody Reactions; D003711:Demyelinating Diseases / Q000276:immunology*; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009407:Nerve Block; D009413:Nerve Fibers, Myelinated / Q000276:immunology*; D009431:Neural Conduction / Q000276:immunology*; D011843:Radiculopathy / Q000276:immunology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D005732:Gangliosides