title: Incidental non-Hodgkin's lymphoma in patients with localized prostate cancer.
abstract: OBJECTIVE
  To determine the outcome of patients with clinically organ-confined prostate cancer undergoing radical retropubic prostatectomy for cure and incidentally discovered concurrent low-grade non-Hodgkin's lymphoma at time of surgery.
  
  
  METHODS
  From September 1986 to September 1997, 4319 patients underwent radical retropubic prostatectomy at our institution. The records of 10 patients incidentally diagnosed to have low-grade non-Hodgkin's lymphoma at the time of radical prostatectomy were retrospectively reviewed.
  
  
  RESULTS
  Of 4319 patients requiring radical prostatectomy, 10 (0.2%) were found to have low-grade non-Hodgkin's lymphoma. All 10 men had an uneventful postoperative course. Two patients subsequently developed progression of lymphoma, one of whom required treatment. One patient died of sepsis associated with his lymphoma and 1 patient died of an unrelated malignancy (lung cancer), both 7 years following surgery. Two patients developed biochemical prostate-specific antigen recurrence. The remainder of men were free of prostate cancer recurrence and experienced no progression of lymphoma at an average of 45 months (range 12 to 142).
  
  
  CONCLUSIONS
  Patients with organ-confined prostate cancer, who are candidates for radical prostatectomy, experience long-term prostate cancer-free survival in the face of incidentally diagnosed low-grade lymphoma. Because the management of most incidentally discovered low-grade lymphomas is expectant, patients discovered at surgery to have this clinical entity should not be denied radical prostatectomy.
authors.affiliation: The James Buchanan Brady Urological Institute and The Johns Hopkins Oncology Center, The Johns Hopkins University Medical Institutions, Baltimore, Maryland, USA.
authors.forename: C F
authors.initials: CF
authors.lastname: Eisenberger
authors.forename: P C
authors.initials: PC
authors.lastname: Walsh
authors.forename: M A
authors.initials: MA
authors.lastname: Eisenberger
authors.forename: N H
authors.initials: NH
authors.lastname: Chow
authors.forename: A W
authors.initials: AW
authors.lastname: Partin
authors.forename: J L
authors.initials: JL
authors.lastname: Mostwin
authors.forename: F F
authors.initials: FF
authors.lastname: Marshall
authors.forename: J I
authors.initials: JI
authors.lastname: Epstein
authors.forename: M
authors.initials: M
authors.lastname: Schoenberg
mesh_terms: D000368:Aged; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000601:surgery*; D012189:Retrospective Studies