Patchy fur, a mouse coat mutation associated with X-Y nondisjunction, maps to the pseudoautosomal boundary region.
Patchy fur is a semidominant X-linked mutation in the mouse, resulting in a sparse coat. The Paf mutation also alters the normal segregation of the X and the Y chromosomes during male meiosis by causing nondisjunction at anaphase I. Analysis of 1139 female meioses from an intersubspecific backcross using 15 PCR-based markers localizes Paf to an approximately 0.2-cM interval that includes the pseudoautosomal boundary. The meiotic nondisjunction phenotype may result from a chromosomal rearrangement that includes pseudoautosomal sequences and affects XY pairing.
Korobova
O
O
Molecular Biology Program, University of Southern California, Los Angeles, California, 90089-1340, USA.
Lane
P W
PW
Perry
J
J
Palmer
S
S
Ashworth
A
A
Davisson
M T
MT
Arnheim
N
N
D000818:Animals; D002874:Chromosome Mapping; D018244:Chromosomes, Artificial, Yeast; D020451:Contig Mapping; D003433:Crosses, Genetic; D017931:DNA Primers; D005260:Female; D005819:Genetic Markers; D006197:Hair / Q000473:pathology / Q000502:physiology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008817:Mice, Mutant Strains; D009154:Mutation; D011110:Polymorphism, Genetic; D014960:X Chromosome
D017931:DNA Primers; D005819:Genetic Markers