In search of novel water soluble forskolin analogues for positive inotropic activity.
Using the novel lead from hydroxy acetyl substituted forskolin analogues, such as 7 beta-hydroxyacetyl-7 beta-deacetyl forskolin or 6 beta-hydroxyacetyl forskolin, a number of water soluble omega-amino acyl derivatives were synthesized. Two such compounds 6 and 18 showed better in vitro activity but failed to show in vivo activity.
Lal
B
B
Department of Chemistry, Hoechst Marion Roussel Limited, Mumbai, India. bansilal@hoechstres.rpgms.ems.vsnl.net.in
Gangopadhyay
A K
AK
Gidwani
R M
RM
Fernandes
M
M
Rajagopalan
R
R
Ghate
A V
AV
D000107:Acetylation; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002415:Cats; D005576:Colforsin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects / Q000502:physiology; D006325:Heart Atria; D006900:Hydroxylation; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology; D012995:Solubility; D013329:Structure-Activity Relationship; D014867:Water
D007202:Indicators and Reagents; D014867:Water; D005576:Colforsin