Lipidic matrix of albendazole sulphoxide: is it an alternative for systemic infections?
As albendazole sulphoxide (ABZS) shows better dissolution properties than albendazole (ABZ), a lipidic matrix with this drug was formulated in order to evaluate if its absorption and so systemic infection chemotherapy could be improved. A cross-over, randomised study in 8 healthy volunteers was carried out, after single administration of 1 g of albendazole or albendazole sulphoxide in lipidic matrix of Gelucire 44/14 (ABZLM and ABZSLM). Absorption was followed performing albendazole sulphoxide dosage in urine samples by high pressure liquid chromatography analysis, during 48 hours. Significant differences were found (p = 0.02) between the urinary recoveries (% E48), being 1.74% and 0.19% the percentage of dose recovered when ABZSLM or of ABZLM were respectively administered. In a previous study of our group similar values were obtained of urinary recovery percentages after albendazole sulphoxide powder administered to another group of healthy volunteers. Lipidic matrix does not improve the physicochemical properties of albendazole sulphoxide powder.
Domínguez
L
L
Laboratory of Pharmacology and Biopharmaceutics, Faculty of Chemistry, Montevideo, Uruguay.
Savio
E
E
Saldaña
J
J
Malanga
A
A
Quevedo
D
D
Camarote
C
C
Ochoa
A
A
Fagiolino
P
P
D000328:Adult; D015766:Albendazole / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D000871:Anthelmintics / Q000008:administration & dosage / Q000493:pharmacokinetics*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D006801:Humans
D000871:Anthelmintics; D015766:Albendazole; C027186:albendazole sulfoxide