title: Effect of zinc sulfate on sensorineural olfactory disorder.
abstract: We administered zinc sulfate to patients with sensorineural (post-viral, post-traumatic, or unknown aetiology) olfactory disorder and examined its effects. The patients were divided into three groups by method of treatment: zinc sulfate only, combination of zinc sulfate and the usual therapy, or the usual therapy. For disorders of post-viral and unknown aetiologies, there were no significant differences in improvement among the three groups. However, for post-traumatic olfactory disorder, the zinc sulfate groups had significantly higher improvement rates than did the group that received the usual therapy. The difference between post-traumatic and post-viral olfactory disorders in the effect of zinc sulfate therapy appeared to depend on the pathology of the associated lesions. In cases of post-traumatic olfactory disorder, regenerative capacity is retained in the olfactory epithelium because the blast cells of olfactory receptor cells remain intact. However, for post-viral olfactory disorder, the lack of olfactory receptor cells and blast cells due to viral infection results in loss of regenerative capacity. We also determined pre-treatment serum zinc concentrations in those patients who planned to be treated with zinc sulfate. Pre-treatment serum zinc concentration was not significantly related to improvement rates.
authors.affiliation: Department of Otolaryngology, Osaka City University, Japan. aibaol@msic.med.osaka-cu.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Aiba
authors.forename: M
authors.initials: M
authors.lastname: Sugiura
authors.forename: J
authors.initials: J
authors.lastname: Mori
authors.forename: K
authors.initials: K
authors.lastname: Matsumoto
authors.forename: K
authors.initials: K
authors.lastname: Tomiyama
authors.forename: F
authors.initials: F
authors.lastname: Okuda
authors.forename: Y
authors.initials: Y
authors.lastname: Nakai
mesh_terms: D006259:Craniocerebral Trauma / Q000150:complications; D006801:Humans; D000857:Olfaction Disorders / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D018035:Receptors, Odorant / Q000502:physiology; D016896:Treatment Outcome; D014777:Virus Diseases / Q000150:complications; D019287:Zinc Sulfate / Q000627:therapeutic use*
chemical_list: D018035:Receptors, Odorant; D019287:Zinc Sulfate