Effect of the IMPase inhibitor L690,330 on sea urchin development.
A variety of concentrations of the IMPase inhibitor L690,330 were added to sea urchin embryos. Immediate arrest of development was obtained for concentrations from 7.5 mm on. Concentrations lower than 3.5 mm permitted gastrulation but inhibited skeletogenesis and disturbed elongation along the animal-vegetal axis. The latter results are similar to those obtained by counteracting lithium effect with myoinositol, which are suggested to be due to partial relief of IMPase inhibition.
Sconzo
G
G
Dipartimento di Biologia Cellulare e dello Sviluppo, Viale delle Scienze, Palermo, Italy.
Cascino
D
D
Amore
G
G
Geraci
F
F
Giudice
G
G
D015720:5'-Nucleotidase / Q000037:antagonists & inhibitors* / Q000502:physiology; D000014:Abnormalities, Drug-Induced / Q000196:embryology / Q000201:enzymology / Q000209:etiology*; D000818:Animals; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000037:antagonists & inhibitors / Q000502:physiology; D004164:Diphosphonates / Q000494:pharmacology / Q000633:toxicity*; D004625:Embryo, Nonmammalian / Q000002:abnormalities / Q000187:drug effects / Q000648:ultrastructure; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000633:toxicity*; D038362:Glycogen Synthase Kinase 3; D007294:Inositol / Q000494:pharmacology; D018021:Lithium Chloride / Q000494:pharmacology / Q000633:toxicity; D009024:Morphogenesis / Q000187:drug effects; D009028:Morula / Q000187:drug effects / Q000648:ultrastructure; D012617:Sea Urchins / Q000187:drug effects* / Q000196:embryology
D004164:Diphosphonates; D004791:Enzyme Inhibitors; C079103:L 690330; D007294:Inositol; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D038362:Glycogen Synthase Kinase 3; D015720:5'-Nucleotidase; D018021:Lithium Chloride