Somatostatin receptor scintigraphy and somatostatin therapy in the evaluation and treatment of malignant thymoma.
OBJECTIVE
This report illustrates the potential diagnostic and therapeutic utility of somatostatin receptor scintigraphy and therapy with somatostatin.


METHODS
In-111 pentetreotide (In-111 octreotide), a somatostatin analog, was used to define the receptor status and the extent of disease in a case of malignant thymoma.


RESULTS
Subsequent treatment with nonradioactive somatostatin inhibited tumor growth.


CONCLUSIONS
In-111 octreotide may be useful to define tumor receptor status and may provide prognostic information useful in determining subsequent therapy.
Lin
K
K
Department of Radiology and Radiological Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA.
Nguyen
B D
BD
Ettinger
D S
DS
Chin
B B
BB
D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006727:Hormone Antagonists / Q000627:therapeutic use*; D006801:Humans; D007205:Indium Radioisotopes; D008479:Mediastinal Neoplasms / Q000556:secondary; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009367:Neoplasm Staging; D015282:Octreotide / Q000031:analogs & derivatives; D010997:Pleural Neoplasms / Q000556:secondary; D011379:Prognosis; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D017481:Receptors, Somatostatin / Q000032:analysis*; D013004:Somatostatin / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D013945:Thymoma / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology / Q000556:secondary; D013953:Thymus Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology
D006727:Hormone Antagonists; D007205:Indium Radioisotopes; D019275:Radiopharmaceuticals; D017481:Receptors, Somatostatin; C094279:indium-111-octreotide; D013004:Somatostatin; C081788:pentetreotide; D015282:Octreotide