[The EAA-ergic modulation of the brain dopaminergic system as a basis for creating new nootropic agents with stress-protective activity].
The paper provides theoretical evidence for and practical confirmation of the possible use of three lipophilic derivatives of N-acetyl-aspartic acid (EAA-AKF-94; AKF-92-10, and PIR-87-6-0). These compounds were shown to display pronounced nootropic activity to correct behavioral, memory, and cognitive disorders in rats exposed to emotional stress. Evidence is provided for the fact that modulation of monoaminergic brain activity mediated by heterosynaptic activation of EAA receptors.
Petrov
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Grigor'ev
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D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D001923:Brain Chemistry / Q000187:drug effects / Q000502:physiology; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D004353:Drug Evaluation, Preclinical; D018697:Nootropic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000502:physiology; D017470:Receptors, Glutamate / Q000187:drug effects* / Q000502:physiology; D013239:Stereotyped Behavior / Q000187:drug effects / Q000502:physiology; D013315:Stress, Psychological / Q000503:physiopathology / Q000517:prevention & control*
C117099:AKF 92-10; C117098:AKF 94; D000928:Antidepressive Agents; C103877:N-acetylaspartic acid di(3-dimethoxyphosphorylpropyl) ester; D018697:Nootropic Agents; D011954:Receptors, Dopamine; D017470:Receptors, Glutamate; D001224:Aspartic Acid