[Multi-systemic toxicity of colchicine and renal failure: apropos of a case].
The use of colchicine can produce various side effects, but multiorgan toxicity is rare. We report the first Swiss case of multiorgan toxicity involving typical neuromuscular lesions. Muscular biopsy is a valuable tool in confirming the diagnosis. Renal insufficiency and hepatobiliary diseases are predisposing factors for such complications. Colchicine pharmacology in the case of renal insufficiency is discussed.
Rosset
L
L
Clinique de médecine interne, Hôpital cantonal, Fribourg.
Descombes
E
E
Fellay
G
G
Regamey
C
C
D000368:Aged; D003078:Colchicine / Q000008:administration & dosage / Q000009:adverse effects*; D006073:Gout / Q000188:drug therapy* / Q000473:pathology; D006074:Gout Suppressants / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000473:pathology; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects / Q000473:pathology; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000473:pathology
D006074:Gout Suppressants; D003078:Colchicine