Neonatal hyperinsulinism.
Hyperinsulinism is the most frequent cause of severe, persistent hypoglycemia in neonates and young infants. Timely diagnosis and aggressive treatment are necessary to prevent long-term neurologic sequelae. This article explores the latest advances in the understanding of the pathophysiology of this disorder at the molecular and cellular level. The clinical features, hallmarks for diagnosis, and various treatment options are discussed.
Schwitzgebel
V M
VM
Department of Pediatrics, University of California at San Francisco, USA.
Gitelman
S E
SE
D003937:Diagnosis, Differential; D005947:Glucose / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D006946:Hyperinsulinism / Q000151:congenital* / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism; D007003:Hypoglycemia / Q000151:congenital*; D007223:Infant; D007231:Infant, Newborn; D010179:Pancreas / Q000196:embryology / Q000254:growth & development; D016896:Treatment Outcome
D005947:Glucose