title: Neuronal subpopulations of developing rat hippocampus containing different calcium-binding proteins behave distinctively in trimethyltin-induced neurodegeneration.
abstract: The present study investigates, by immunocytochemistry, the behavior of different neuronal subpopulations of the developing rat hippocampus, selectively labeled by the calcium-binding proteins calbindin D28-k (CB), parvalbumin (PV), and calretinin (CR), in neurodegenerative processes induced by the neurotoxicant trimethyltin (TMT). Previous studies on adult rats indicated that CB-immunoreactive (IR) neurons were affected by TMT, while PV- and CR-IR neurons were selectively spared. The present findings show that only CR-IR neurons are spared in developing rats, and in addition the number of CR-IR neurons are significantly higher in the DG of treated animals. On the contrary, PV-IR neurons, spared in adult rats, were affected by TMT during development. CB-IR neurons were affected also in developing rats, as in adults. The different postnatal time-courses of calcium-binding protein expression in relationship to the time of TMT administration (presence of CR but absence of PV) could have a role in the different behavior of CR- and PV-IR cells in developing rats.
authors.affiliation: Institute of Histology, Catholic University, Rome, 00168, Italy.
authors.forename: M C
authors.initials: MC
authors.lastname: Geloso
authors.forename: P
authors.initials: P
authors.lastname: Vinesi
authors.forename: F
authors.initials: F
authors.lastname: Michetti
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001923:Brain Chemistry / Q000502:physiology; D064032:Calbindin 2; D064026:Calbindins; D006624:Hippocampus / Q000166:cytology* / Q000254:growth & development; D009410:Nerve Degeneration / Q000139:chemically induced / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000032:analysis; D009474:Neurons / Q000737:chemistry / Q000166:cytology* / Q000378:metabolism; D010320:Parvalbumins / Q000032:analysis*; D051381:Rats; D064030:S100 Calcium Binding Protein G / Q000032:analysis*; D014298:Trimethyltin Compounds
chemical_list: C576512:Calb2 protein, rat; D064032:Calbindin 2; D064026:Calbindins; D009419:Nerve Tissue Proteins; D010320:Parvalbumins; D064030:S100 Calcium Binding Protein G; D014298:Trimethyltin Compounds; C046488:trimethyltin