title: The importance of cerebrospinal fluid lactate in the evaluation of congenital lactic acidosis.
abstract: In 27 of 28 children with congenital lactic acidosis, cerebrospinal fluid lactate was higher than venous blood lactate. The mean +/- SEM difference between these variables was 2.4 +/- 0.3 mmol/L (P =.0001). Girls or patients with pyruvate dehydrogenase deficiency had higher cerebrospinal fluid lactate concentrations than boys or patients with respiratory chain defects or mitochondrial DNA mutations.
authors.affiliation: Departments of Medicine (Division of Endocrinology and Metabolism), University of Florida, College of Medicine, Gainesville, USA.
authors.forename: P W
authors.initials: PW
authors.lastname: Stacpoole
authors.forename: S T
authors.initials: ST
authors.lastname: Bunch
authors.forename: R E
authors.initials: RE
authors.lastname: Neiberger
authors.forename: L A
authors.initials: LA
authors.lastname: Perkins
authors.forename: R
authors.initials: R
authors.lastname: Quisling
authors.forename: A D
authors.initials: AD
authors.lastname: Hutson
authors.forename: M
authors.initials: M
authors.lastname: Greer
mesh_terms: D000140:Acidosis, Lactic / Q000134:cerebrospinal fluid* / Q000151:congenital*; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004272:DNA, Mitochondrial / Q000235:genetics; D004579:Electron Transport; D005260:Female; D006801:Humans; D007223:Infant; D007773:Lactates / Q000097:blood / Q000134:cerebrospinal fluid*; D008297:Male; D009154:Mutation; D015325:Pyruvate Dehydrogenase Complex Deficiency Disease / Q000134:cerebrospinal fluid / Q000378:metabolism*
chemical_list: D004272:DNA, Mitochondrial; D007773:Lactates