Effects of 4 hours magnesium sulfate infusion on fetal heart rate variability and reactivity in a goat model.
Effects of magnesium sulfate were investigated on fetal heart rate (FHR) baseline, variability, and reactivity in goats. Six chronically catheterized fetuses of Japanese Saanen goat at 125 to 130 days' gestation (term = 147 days) were used. Magnesium sulfate was directly infused to the fetuses. Short-term variability and long-term variability were obtained according to Huey et al. The baseline, reactivity, short-term variability and long-term variability of the FHR were compared between those receiving magnesium sulfate infusions and those receiving vehicle infusions without magnesium sulfate for 4 hr. Two-way analysis of variance (ANOVA) and Duncan's multiple range test was applied for statistical significance. Four hours magnesium sulfate infusion significantly increased fetal plasma concentration of magnesium from 2.4-6.6 mg/dL, without significant changes in fetal respiratory gases and pH values. The baseline FHR was significantly decreased by magnesium infusion compared with that receiving vehicle infusion. The incidence of acceleration, short-term variability, and long-term variability during the fourth hour of magnesium infusion was also significantly decreased compared to a controlled infusion. The time spent by high amplitude phase of short-term variability and that of long-term variability were also significantly reduced. Significant correlation was obtained between the magnesium concentration and incidence of acceleration at fourth hour of magnesium infusion. Four hours infusion of magnesium sulfate significantly decreases baseline FHR, short-term variability, long-term variability, and reactivity in fetal goats at 0.85 gestation.
Sameshima
H
H
Perinatal Center and Department of Obstetrics and Gynecology, Miyazaki Medical College, Kiyotake, Japan.
Ikenoue
T
T
Kamitomo
M
M
Sakamoto
H
H
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage* / Q000494:pharmacology; D002245:Carbon Dioxide / Q000097:blood; D004562:Electrocardiography; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D006041:Goats; D006340:Heart Rate, Fetal / Q000187:drug effects*; D008274:Magnesium / Q000097:blood; D008278:Magnesium Sulfate / Q000008:administration & dosage* / Q000494:pharmacology; D010100:Oxygen / Q000097:blood; D011247:Pregnancy
D000889:Anti-Arrhythmia Agents; D002245:Carbon Dioxide; D008278:Magnesium Sulfate; D008274:Magnesium; D010100:Oxygen