Primary thrombophilia in Mexico: a prospective study.
A group of 102 Mexican Mestizo patients with appropriate clinical features suggestive of primary thrombophilia was prospectively studied. Thirty-nine percent of them had activated protein C resistance, but only four patients displayed the factor V Leiden mutation. Five percent of the individuals were found to be protein C deficient, whereas 2% had protein S deficiency. No cases of abnormalities in antithrombin III, plasminogen, tissue-type plasminogen activator or plasminogen activator inhibitor were found. The low prevalence of the activated protein C resistance genotype, probably stemming from the genetic admixture of the Mexican Mestizo group is noteworthy.
Ruiz-Argüelles
G J
GJ
Centro de Hematología y Medicina Interna de Puebla, Mexico.
González-Estrada
S
S
Garcés-Eisele
J
J
Ruiz-Argüelles
A
A
D020016:Activated Protein C Resistance / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D006801:Humans; D007198:Indians, North American / Q000235:genetics; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D010641:Phenotype; D015995:Prevalence; D011446:Prospective Studies; D020151:Protein C Deficiency / Q000453:epidemiology / Q000208:ethnology; D018455:Protein S Deficiency / Q000453:epidemiology / Q000208:ethnology; D013927:Thrombosis / Q000453:epidemiology* / Q000208:ethnology / Q000235:genetics; D044465:White People / Q000235:genetics*