Structure-activity relationship homology (SARAH): a conceptual framework for drug discovery in the genomic era.
Extension of the traditional pharmacological approach of protein target classification to whole target systems has the potential to relate elements of protein sequence to the structure-activity relationship (SAR) of small molecules that can modulate protein action. Grouping potential drug discovery targets into families based on the relatedness of their SAR provides a means to translate the information from genome-sequencing efforts into knowledge that will aid in the discovery of drugs.
Frye
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Division of Chemistry Glaxo Wellcome Inc., 3.4134 5 Moore Drive Research Triangle Park NC 27709 USA. svf3511@glaxowellcome.com
D002626:Chemistry, Pharmaceutical; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D011494:Protein Kinases / Q000737:chemistry; D011506:Proteins / Q000737:chemistry* / Q000145:classification; D017386:Sequence Homology, Amino Acid; D013329:Structure-Activity Relationship
D011506:Proteins; D011494:Protein Kinases