title: Intravascular ultrasound (IVUS) examination reverses therapeutic decision from percutaneous intervention to a surgical approach in patients with alterations of the left main stem.
abstract: Intravascular ultrasound (IVUS) represents a new method to assess vessel lumen and wall morphology. To prospectively evaluate the usefulness of IVUS for further therapeutic decisions in left main stem (LM) lesions with unclear angiographic definition, this study was launched. We studied 56 patients with significant stenosis of the LAD and/or LCX arteries and questionable LM morphology. 30-MHz IVUS catheters with 2.9 or 3.2 F outer diameters were used. A significant luminal reduction of the left main stem was defined as an area stenosis greater than 50% or a minimal luminal diameter smaller than 3 mm as determined by IVUS. 36 of 56 patients (61%) fulfilled these criteria. Additionally, 12 patients showed a ruptured plaque within the LM. 30 of these 36 patients were originally thought to be candidates for angioplasty. After positive IVUS 34 of these 36 patients were sent to surgery. No perioperative ischemic complications occurred. In angiographically unclear left main stem findings. IVUS establishes a definitive diagnosis. After IVUS confirmation of significant left main stem pathology operative management should be the preferred approach as compared to transluminal coronary interventions. However, prospective randomized studies are needed to define the most efficient approach.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, University of Essen Medical School, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Wolfhard
authors.forename: G
authors.initials: G
authors.lastname: Görge
authors.forename: T
authors.initials: T
authors.lastname: Konorza
authors.forename: M
authors.initials: M
authors.lastname: Haude
authors.forename: J
authors.initials: J
authors.lastname: Ge
authors.forename: J A
authors.initials: JA
authors.lastname: Piotrowski
authors.forename: F H
authors.initials: FH
authors.lastname: Splittgerber
authors.forename: V
authors.initials: V
authors.lastname: Sadony
authors.forename: R
authors.initials: R
authors.lastname: Erbel
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D017023:Coronary Angiography; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000601:surgery / Q000628:therapy*; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D011446:Prospective Studies; D018084:Ultrasonography, Interventional