Detection of cytotoxic effects of Clostridium novyi type A on bovine kidney cells.
The cytotoxic effects of a toxic preparation from Clostridium novyi type A were demonstrated on tissue-cultured bovine kidney cells. The cytotoxic response was dose-dependent and could be neutralized by homologous antiserum. Scanning electron microscopy revealed damaged kidney cell surfaces. These findings indicated that the cytotoxicity may contribute to the formation of the foci in bovine tissue during an infection with C. novyi.
Kanoe
M
M
Laboratory of Animal Health, Tokyo University of Agriculture, Japan.
Masui
Y
Y
Murakami
Y
Y
Yaguchi
Y
Y
D000818:Animals; D000918:Antibody Specificity; D001427:Bacterial Toxins / Q000494:pharmacology*; D002417:Cattle; D002478:Cells, Cultured / Q000187:drug effects; D003013:Clostridium / Q000737:chemistry* / Q000472:pathogenicity; D007668:Kidney / Q000166:cytology / Q000187:drug effects; D008855:Microscopy, Electron, Scanning; D009500:Neutralization Tests; D013997:Time Factors
D001427:Bacterial Toxins; C075216:Clostridium novyi alpha-toxin