Constructing the human cerebral cortex during infancy and childhood: types and numbers of cortical columns and numbers of neurons in such columns at different age-points.
This study examines JL Conel's data on neuron numbers in 35 human cortical areas for eight age points from 0 (birth) to 72 months, to analyze cortical columns, the presumed functional units of the cortex. For each cortical area at each age point, cortical surface divided by the square root of the area's neuron number gives cross-sectional areas with radii ranging from 180 microns at birth to 250 microns at 72 months. For the prefrontal cortex at birth and 48 months, these radii are approximately 2.10 and 1.19 times the longest radial basal dendrites, suggesting similar dimensions between these two measures of column radius. The logarithm of neuron number per cortical area and age point was examined in relation to the Weber-Fechner law governing the relationship between stimulus intensity and perception. A mechanism for this law consistent with the cortical model of Douglas et al. illustrates the importance of local circuit neurons. The cross-sectional areas of hexagonal columns for prefrontal cortex, using as radius, the longest radial extent of layer 5 pyramidal neuron basal dendrites, ranging from 0.013 mm2 at birth to 0.064 mm2 at 48 months, suggests that functional cortical columns increase cross-sectional area during development. These cross-sectional areas are 55-100-fold larger at birth, and 229-277-fold larger at 48 months, than those computed from somal width in prefrontal, layer 5 pyramidal neurons. Comparison of radial extent of pyramidal basal dendrites to their soma-to-soma distances shows that layer 3 pyramidal basal dendrites reach 1.5 and 4.0 other pyramidal neurons at 15 and 60 months, respectively, while layer 5, extra-large pyramidal basal dendrites reach 1.14 and 1.72 other such neurons at birth and 48 months, respectively. If such a relationship holds for other cortical areas, then the Conel data can be used to estimate basal dendrite extent, for which there currently is a paucity of data.
Landing
B H
BH
Department of Pathology and of Pediatrics, University of Southern California School of Medicine, USA.
Shankle
W R
WR
Hara
J
J
D000375:Aging / Q000502:physiology*; D001931:Brain Mapping; D002452:Cell Count; D002540:Cerebral Cortex / Q000166:cytology / Q000254:growth & development*; D002648:Child; D002675:Child, Preschool; D003627:Data Interpretation, Statistical; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009474:Neurons / Q000166:cytology*; D009929:Organ Size