title: Simultaneous assessment of cerebral hemodynamics and contrast agent uptake in lesions with disrupted blood-brain-barrier.
abstract: The purpose of this study was to develop a method that eliminates the influence of the T1 relaxation time upon the signal-time course in perfusion-weighted imaging of cerebral lesions with blood-brain-barrier (BBB) disruption. On a 1.5 T whole body clinical magnetic resonance (MR) imager, we implemented a dual-echo RF-spoiled FLASH sequence (TE=6/23.6 ms). We developed a postprocessing routine that allowed to calculate a signal-time course representing only the change in T2* and another one representing only the change in T1. Using this method, we examined 7 patients with various brain lesions showing evidence of BBB disruption. In the signal-time-curves obtained from the early echo we found a distinct signal drop due to the T2* effect. These effects could be eliminated by the correction algorithm yielding a 67% higher signal increase. Correction of the signal-time curve of the late echo yielded a more pronounced maximum signal drop and a decrease in postcontrast signal intensity. We found that without this correction the relative regional cerebral blood volume and the first moment of the concentration-time curve were underestimated by 72% and 22%, respectively. The dual echo-sequence combined with the postprocessing algorithm separates T1 and T2* effects and thus allows to assess cerebral hemodynamics and contrast agent kinetics simultaneously. This method may be a useful tool for characterizing, staging, and therapy monitoring of brain tumors.
authors.affiliation: Department of Neuroradiology, University of Heidelberg Medical School, Germany. Sabine_Heiland@ukl.uni-heidelberg.de
authors.forename: S
authors.initials: S
authors.lastname: Heiland
authors.forename: T
authors.initials: T
authors.lastname: Benner
authors.forename: J
authors.initials: J
authors.lastname: Debus
authors.forename: K
authors.initials: K
authors.lastname: Rempp
authors.forename: W
authors.initials: W
authors.lastname: Reith
authors.forename: K
authors.initials: K
authors.lastname: Sartor
mesh_terms: D000328:Adult; D000368:Aged; D001810:Blood Volume; D001812:Blood-Brain Barrier; D001921:Brain / Q000473:pathology; D001922:Brain Abscess / Q000503:physiopathology; D001932:Brain Neoplasms / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D003287:Contrast Media; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged
chemical_list: D003287:Contrast Media