[Clinical use of leuprolide acetate depot in a group of gynecologic patients in the preoperative period].
BACKGROUND
The authors examined 33 patients with symptomatic uterine leiomyomas due to undergo total hysterectomy in order to evaluate the effects of treatment with GnRH analogues on leiomyoma and estrogen and progesterone receptors.


METHODS
The patients were divided into two groups: one group was treated with leuprolide acetate (Group A) and the other did not receive treatment (Group B).


RESULTS
A significant reduction in the volume of leiomyomas and estrogen and progesterone receptors was noted in patients in Group A.


CONCLUSIONS
Treatment with GnRH analogues therefore represents a valid aid for patients with uterine leiomyomas and sideropenic anemia awaiting surgery.
Russo
P
P
I Istituto di Ostetricia e Ginecologia, Università degli Studi di Roma, La Sapienza.
Ciolli
P
P
Atlante
M
M
Carico
E
E
Mancini
R
R
Russo
R
R
Vecchione
A
A
D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007889:Leiomyoma / Q000601:surgery*; D016729:Leuprolide / Q000008:administration & dosage* / Q000494:pharmacology; D008875:Middle Aged; D011229:Preanesthetic Medication; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000601:surgery*
D018931:Antineoplastic Agents, Hormonal; D016729:Leuprolide