title: Human cytochrome P450s: selectivity and measurement in vivo.
authors.affiliation: Department of Drug Metabolism, Pfizer Central Research, Sandwich, UK.
authors.forename: D A
authors.initials: DA
authors.lastname: Smith
authors.forename: S M
authors.initials: SM
authors.lastname: Abel
authors.forename: R
authors.initials: R
authors.lastname: Hyland
authors.forename: B C
authors.initials: BC
authors.lastname: Jones
mesh_terms: D001189:Aryl Hydrocarbon Hydroxylases; D002753:Chlorzoxazone / Q000378:metabolism / Q000494:pharmacology; D019388:Cytochrome P-450 CYP1A2 / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D019389:Cytochrome P-450 CYP2D6 / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D019392:Cytochrome P-450 CYP2E1 / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D051544:Cytochrome P-450 CYP3A; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D007527:Isoenzymes; D006899:Mixed Function Oxygenases / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D010672:Phenytoin / Q000378:metabolism / Q000494:pharmacology; D039181:Steroid 16-alpha-Hydroxylase; D013250:Steroid Hydroxylases / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D013329:Structure-Activity Relationship; D014044:Tolbutamide / Q000378:metabolism / Q000494:pharmacology
chemical_list: D065607:Cytochrome P-450 Enzyme Inhibitors; D004791:Enzyme Inhibitors; D007527:Isoenzymes; D010672:Phenytoin; D003577:Cytochrome P-450 Enzyme System; D014044:Tolbutamide; D006899:Mixed Function Oxygenases; D013250:Steroid Hydroxylases; D019392:Cytochrome P-450 CYP2E1; D001189:Aryl Hydrocarbon Hydroxylases; C504573:CYP1A2 protein, human; C104464:CYP3A protein, human; D019388:Cytochrome P-450 CYP1A2; D019389:Cytochrome P-450 CYP2D6; D051544:Cytochrome P-450 CYP3A; D039181:Steroid 16-alpha-Hydroxylase; D002753:Chlorzoxazone