Inhibition of anaesthetic-induced emesis by a NK1 or 5-HT3 receptor antagonist in the house musk shrew, Suncus murinus.
The effects of a NK1 antagonist, GR205171, and a 5-HT3 antagonist, ondansetron, in a novel model of post-anaesthesia-induced emesis in Suncus murinus is described. GR205171 (1 and 3 mg k(-1) s.c) and ondansetron (3 mg kg(-1) s.c.) each significantly inhibited emesis. This model may be useful for studying drugs to treat post-operative nausea and vomiting in man.
Gardner
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Systems Biology Department, GlaxoWellcome Research and Development, Medicines Research Centre, Stevenage, Herts, UK. cjg0872@glaxowellcome.co.uk
Perren
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D000758:Anesthesia / Q000009:adverse effects*; D000818:Animals; D006221:Halothane; D006801:Humans; D008297:Male; D009325:Nausea / Q000209:etiology / Q000517:prevention & control*; D064729:Neurokinin-1 Receptor Antagonists; D017294:Ondansetron / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology*; D011985:Receptors, Serotonin / Q000502:physiology*; D044406:Receptors, Serotonin, 5-HT3; D012702:Serotonin Antagonists / Q000494:pharmacology*; D012788:Shrews; D013777:Tetrazoles / Q000494:pharmacology*; D014839:Vomiting / Q000209:etiology / Q000517:prevention & control*
D064729:Neurokinin-1 Receptor Antagonists; D010880:Piperidines; D011985:Receptors, Serotonin; D044406:Receptors, Serotonin, 5-HT3; D012702:Serotonin Antagonists; D013777:Tetrazoles; D017294:Ondansetron; C103207:vofopitant; D006221:Halothane