Late-presenting acute acetaminophen toxicity and the role of N-acetylcysteine.
NAC is an effective antidote for APAP toxicity. NAC has been shown to be effective for early toxicity and is gaining acceptance for late toxicity. As the knowledge of APAP toxicity advances, the duration and route of NAC administration may be clarified.
Tucker
J R
JR
University of Connecticut School of Medicine, Department of Pediatrics, Hartford, USA.
D000082:Acetaminophen / Q000506:poisoning*; D000111:Acetylcysteine / Q000627:therapeutic use*; D000208:Acute Disease; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000506:poisoning*; D000931:Antidotes / Q000627:therapeutic use*; D056486:Chemical and Drug Induced Liver Injury; D002648:Child; D002985:Clinical Protocols; D062787:Drug Overdose / Q000150:complications / Q000188:drug therapy; D006801:Humans; D008107:Liver Diseases / Q000517:prevention & control; D012307:Risk Factors; D013997:Time Factors
D018712:Analgesics, Non-Narcotic; D000931:Antidotes; D000082:Acetaminophen; D000111:Acetylcysteine