title: Exploratory thoughts on clinical trials with utilities.
abstract: We consider problems of choice of sample size and allocation in the clinical trials context when utilities are explicitly taken into account. In particular, we consider utilities of benefits and side-effects (and their trade-offs), as well as utility functions that trade-off scientific and ethical concerns.
authors.affiliation: Department of Mathematics, Imperial College of Science, Technology & Medicine, London, U.K.
authors.forename: S B
authors.initials: SB
authors.lastname: Tan
authors.forename: A F
authors.initials: AF
authors.lastname: Smith
mesh_terms: D001499:Bayes Theorem; D002986:Clinical Trials as Topic / Q000379:methods / Q000706:statistics & numerical data; D006801:Humans; D015233:Models, Statistical; D018401:Sample Size; D016008:Statistical Distributions