Cell lineage tracing in heart development.
Photolysis-based lineage determination is especially useful in addressing late-stage lineage definitions. Although we have focused on the heart lineage, this technique is readily applicable to any region of the embryo. Furthermore, the concomitant analysis of gene expression and lineage restriction within the same embryo will help define the signaling cascades that direct normal cell fate and the regulative changes that mark vertebrate organ development.
Serluca
F C
FC
Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA.
Fishman
M C
MC
D000818:Animals; D019070:Cell Lineage / Q000502:physiology*; D006321:Heart / Q000196:embryology*; D009206:Myocardium / Q000166:cytology*; D015027:Zebrafish / Q000196:embryology*