title: Endoluminal instillation of bisacodyl in patients with severe (slow transit type) constipation is useful to test residual colonic propulsive activity.
abstract: BACKGROUND
  Chronic constipation is a frequent symptom among the general population, and a minority of cases do not respond to any therapeutic measures, except surgery. The purpose of this study was to test the residual colonic motor propulsive activity with a pharmacologic stimulus in a series of patients referred for severe constipation.
  
  
  METHODS
  Twenty-five chronically constipated patients, slow transit type, age range 16-71 years, unresponsive to conventional medical treatment and referred for functional evaluation, entered the study.
  
  
  METHODS
  Colonic manometry by means of an endoscopically positioned probe was carried out in all patients. Following a basal recording period, a placebo solution followed by 10 mg bisacodyl solution was infused into the colon through the more proximal recording port.
  
  
  RESULTS
  After bisacodyl infusion, about 90% of patients showed a motor response characterized by the appearance (within on average 13 +/- 3 min) of one or more high-amplitude propagated contractions, the manometric equivalent of mass movements, and about 75% of these were followed (mean 18.5 +/- 4 min) by defecation.
  
  
  CONCLUSIONS
  Physiological and pharmacological testing of colonic motor activity may be important in severely constipated patients, especially in those labeled as 'intractable', in whom more in depth investigation planning may encourage further therapeutic efforts.
authors.affiliation: Laboratorio di Motilità Intestinale, Sezione di Gastroenterologia ed Endoscopia Digestiva, Dipartimento di Medicina, Clinica, Patologia e Farmacologia, Università di Perugia, Italia.
authors.forename: G
authors.initials: G
authors.lastname: Bassotti
authors.forename: G
authors.initials: G
authors.lastname: Chiarioni
authors.forename: U
authors.initials: U
authors.lastname: Germani
authors.forename: E
authors.initials: E
authors.lastname: Battaglia
authors.forename: I
authors.initials: I
authors.lastname: Vantini
authors.forename: A
authors.initials: A
authors.lastname: Morelli
mesh_terms: D000328:Adult; D001726:Bisacodyl / Q000008:administration & dosage*; D002400:Cathartics / Q000008:administration & dosage*; D002908:Chronic Disease; D003106:Colon / Q000503:physiopathology*; D003248:Constipation / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D005772:Gastrointestinal Transit / Q000502:physiology; D006801:Humans; D007322:Instillation, Drug; D008297:Male; D008365:Manometry
chemical_list: D002400:Cathartics; D001726:Bisacodyl