title: Characterization of Fe(III)-deferoxamine and Mn(II)-pectin as magnetic resonance imaging contrast agents.
abstract: To find new contrast agents for magnetic resonance imaging (MRI), the spin-lattice relaxation time (T1)-reducing activities of metal complexes of EDTA, N-hydroxyethyethylenediamine-N,N',N'-triacetic acid (HEDTA), diethylenetriamine-N,N,N',N'',N''-pentaacetic acid (DTPA), deferoxamine, mugineic acid, and pectin with Fe(III) or Mn(II) were investigated. Strong activity was found in Fe(III)-deferoxamine, Fe(III)-mugineic acid, or Mn(II)-pectin. In the actual MRI tomogram, Fe(III)-deferoxamine exhibited a contrast-enhancing effect comparable with that of Gd(III)-DTPA, and a much stronger effect was observed for Mn(II)-pectin. Fe(III)-deferoxamine and the Mn(II)-pectin appear to be candidates, respectively, as a new intravenous contrast agent and an oral gastrointestinal one.
authors.affiliation: Department of Pharmacognosy, Osaka University of Pharmaceutical Sciences, Takatsuki, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Mino
authors.forename: H
authors.initials: H
authors.lastname: Kitagaki
authors.forename: M
authors.initials: M
authors.lastname: Sasaki
authors.forename: K
authors.initials: K
authors.lastname: Ishii
authors.forename: T
authors.initials: T
authors.lastname: Mori
authors.forename: K
authors.initials: K
authors.lastname: Yamada
authors.forename: O
authors.initials: O
authors.lastname: Nagasawa
mesh_terms: D002614:Chelating Agents / Q000737:chemistry; D003287:Contrast Media / Q000737:chemistry*; D003676:Deferoxamine / Q000031:analogs & derivatives / Q000737:chemistry*; D004492:Edetic Acid / Q000031:analogs & derivatives / Q000737:chemistry; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010368:Pectins / Q000737:chemistry*; D004369:Pentetic Acid / Q000737:chemistry
chemical_list: D002614:Chelating Agents; D003287:Contrast Media; D004369:Pentetic Acid; D010368:Pectins; D004492:Edetic Acid; D003676:Deferoxamine; C026060:N-(hydroxyethyl)ethylenediaminetriacetic acid