The role of dual energy x-ray absorptiometry in aiding the diagnosis of pediatric osteogenesis imperfecta.
The role of dual energy x-ray absorptiometry (DEXA) in the evaluation of the pediatric patient with multiple fractures has not been well established. We retrospectively examined the medical records of 45 patients who had presented to our institution with multiple fractures of unknown cause, who were not known to have osteogenesis imperfecta, and who had obtained DEXA as part of their evaluation. Of these, 26 patients had sufficient clinical data for inclusion in this study. Patients underwent DEXA of the anteroposterior spine and whole body. A z score was calculated to normalize the DEXA values for age. The diagnosis of osteogenesis imperfecta was correlated with the outcome of each DEXA scan to assess the validity of DEXA as a diagnostic tool. The DEXA of the anteroposterior spine had the highest sensitivity at 91.7%, while DEXA of the whole body had the highest specificity at 100.0%. Decreased bone mineral density may be associated with osteogenesis imperfecta, and DEXA is helpful in detecting low bone mineral density that may be missed on plain radiographs of children with milder forms of osteogenesis imperfecta.
Moore
M S
MS
Walter Reed Army Medical Center, Washington, DC, USA.
Minch
C M
CM
Kruse
R W
RW
Harcke
H T
HT
Jacobson
L
L
Taylor
A
A
D015502:Absorptiometry, Photon; D000293:Adolescent; D015519:Bone Density / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D050723:Fractures, Bone / Q000150:complications*; D006801:Humans; D008297:Male; D009104:Multiple Trauma / Q000150:complications*; D010013:Osteogenesis Imperfecta / Q000175:diagnosis* / Q000209:etiology; D012016:Reference Values; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012984:Software