title: [Value of detection of carcinoma in situ in conservative surgery of germ cell tumors of the testis].
abstract: OBJECTIVE
  It is currently proposed to perform tumour enucleation in mono-orchid patients presenting with a small germ cell tumour, in order to preserve physiological endocrine function. However, this conservative surgery must be accompanied by treatment of any carcinoma in situ lesions present in the remaining testicular parenchyma.
  
  
  METHODS
  The presence of carcinoma in situ was investigated in 35 patients with germ cell tumour of the testis on samples obtained from the presumably healthy pulp of the orchidectomy specimen, adjacent to and away from the tumour. Samples away from the tumour were performed according to principle of surgical testicular biopsy. Histological examination also concerned the tissue situated in contact with the tumour.
  
  
  RESULTS
  25 patients (74.22%) presented intratubular germ cell dysplasia in the testicular parenchyma presumed to be healthy. These lesions were always concomitantly observed on samples performed adjacent to and away from the tumour. It was observed more frequently in seminomas, but was also observed in other histological forms.
  
  
  CONCLUSIONS
  Because of the diffuse nature of carcinoma in situ in germ cell tumours of the testis, pulp samples adjacent to the tumour are sufficient to ensure the diagnosis during conservative surgery. Carcinoma in situ is currently treated by local radiotherapy.
authors.affiliation: Clinique d'Urologie, Hôpital d'Instruction des Armées du Val de Grâce, Paris.
authors.forename: A
authors.initials: A
authors.lastname: Houlgatte
authors.forename: R
authors.initials: R
authors.lastname: Fournier
authors.forename: P
authors.initials: P
authors.lastname: Camparo
authors.forename: A
authors.initials: A
authors.lastname: de la Taille
authors.forename: P
authors.initials: P
authors.lastname: Berlizot
authors.forename: P
authors.initials: P
authors.lastname: Houdelette
mesh_terms: D000293:Adolescent; D000328:Adult; D002278:Carcinoma in Situ / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D018237:Germinoma / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009919:Orchiectomy; D011879:Radiotherapy Dosage; D018239:Seminoma / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D013736:Testicular Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D013737:Testis / Q000473:pathology