A second Candida albicans resistance gene (Carg2) regulates tissue damage, but not fungal clearance, in sub-lethal murine systemic infection.
The severity of systemic infection with the yeast Candida albicans has been shown to be under complex genetic control. C57/L mice carry an allele that is associated with an increase in tissue destruction when compared with C57Bl/6 mice; however, the gene affects only the severity of tissue lesions, and does not influence the magnitude of the fungal burden in either kidney or brain. Studies in [C57/LxC57Bl/6]F1 hybrid mice, and [C57/LxC57Bl/6]F1xC57/L backcross mice, demonstrated that the gene behaves as a simple Mendelian co-dominant.
Ashman
R B
RB
School of Dentistry, University of Queensland, Brisbane, Qld., Australia.
Fulurija
A
A
Papadimitriou
J M
JM
D000483:Alleles; D000818:Animals; D001927:Brain Diseases / Q000235:genetics / Q000382:microbiology / Q000473:pathology; D002176:Candida albicans / Q000235:genetics* / Q000472:pathogenicity; D002177:Candidiasis / Q000235:genetics* / Q000382:microbiology / Q000473:pathology; D005800:Genes, Fungal / Q000235:genetics*; D007674:Kidney Diseases / Q000235:genetics / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D012680:Sensitivity and Specificity