title: Patchy fur, a mouse coat mutation associated with X-Y nondisjunction, maps to the pseudoautosomal boundary region.
abstract: Patchy fur is a semidominant X-linked mutation in the mouse, resulting in a sparse coat. The Paf mutation also alters the normal segregation of the X and the Y chromosomes during male meiosis by causing nondisjunction at anaphase I. Analysis of 1139 female meioses from an intersubspecific backcross using 15 PCR-based markers localizes Paf to an approximately 0.2-cM interval that includes the pseudoautosomal boundary. The meiotic nondisjunction phenotype may result from a chromosomal rearrangement that includes pseudoautosomal sequences and affects XY pairing.
authors.affiliation: Molecular Biology Program, University of Southern California, Los Angeles, California, 90089-1340, USA.
authors.forename: O
authors.initials: O
authors.lastname: Korobova
authors.forename: P W
authors.initials: PW
authors.lastname: Lane
authors.forename: J
authors.initials: J
authors.lastname: Perry
authors.forename: S
authors.initials: S
authors.lastname: Palmer
authors.forename: A
authors.initials: A
authors.lastname: Ashworth
authors.forename: M T
authors.initials: MT
authors.lastname: Davisson
authors.forename: N
authors.initials: N
authors.lastname: Arnheim
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D018244:Chromosomes, Artificial, Yeast; D020451:Contig Mapping; D003433:Crosses, Genetic; D017931:DNA Primers; D005260:Female; D005819:Genetic Markers; D006197:Hair / Q000473:pathology / Q000502:physiology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008817:Mice, Mutant Strains; D009154:Mutation; D011110:Polymorphism, Genetic; D014960:X Chromosome
chemical_list: D017931:DNA Primers; D005819:Genetic Markers