title: Central nervous system relapse of treated stage IV neuroblastoma.
abstract: Neuroblastoma is the most common extracranial solid tumor in pediatrics. The long-term survival of patients with advanced-stage neuroblastoma has remarkably improved secondary to aggressive treatment protocols including autologous bone marrow transplant (BMT). As a result, a different natural history of this disease is being reported with unusual, late manifestations. The central nervous system (CNS), once a rare site of disease, is being involved with increasing frequency. Appropriate neuroimaging in these patients is important. Two cases of patients with treated stage IV neuroblastoma who developed isolated CNS metastases are presented. The proposed pathogenesis and neuroradiologic manifestations of this complication are reviewed.
authors.affiliation: Department of Radiology, Division of Neuroradiology, Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.
authors.forename: S
authors.initials: S
authors.lastname: Palasis
authors.forename: J C
authors.initials: JC
authors.lastname: Egelhoff
authors.forename: J D
authors.initials: JD
authors.lastname: Morris
authors.forename: B L
authors.initials: BL
authors.lastname: Koch
authors.forename: W S
authors.initials: WS
authors.lastname: Ball
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000473:pathology / Q000628:therapy*; D016543:Central Nervous System Neoplasms / Q000175:diagnosis* / Q000556:secondary*; D006801:Humans; D007223:Infant; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000556:secondary; D009447:Neuroblastoma / Q000175:diagnosis* / Q000556:secondary* / Q000628:therapy