Clinical models of chemoprevention for cervical cancer.
Cervical carcinoma creates a worldwide, significant population burden that potentially could be reduced by new preventive strategies for cervical cancer such as chemoprevention. Given the vast array of clinical and molecular information available relating to cervical cancer and the precursor lesions along with a growing number of new molecular techniques, a model is needed to guide further investigation. Such a model would facilitate research design, guide hypothesis development and testing, and focus the use of molecular data collection and analysis. This article reviews the clinical and molecular data of cervical cancer and the precursor lesions in order to develop a model for chemoprevention research in cervical cancer.
Ruffin
M T
MT
Department of Family Practice, University of Michigan Medical School, Ann Arbor, USA.
Lancaster
W D
WD
D018890:Chemoprevention; D005260:Female; D006801:Humans; D002583:Uterine Cervical Neoplasms / Q000503:physiopathology / Q000517:prevention & control*