Anxiolytic effect of motilin and reversal with GM-109, a motilin antagonist, in mice.
There have been few reports on the effects of the brain-gut peptide motilin on the central nervous system (CNS). We administered motilin intracerebroventricularly to mice and investigated the effect of motilin on anxiety using an elevated plus-maze. Motilin produced a significant decrease in anxiety with an inverted U-shaped dose response. To determine whether the anxiolytic effect of motilin was mediated via motilin receptors in the brain, the effect of GM-109, a novel motilin receptor antagonist, was investigated. GM-109 showed a significant and dose-dependent antagonism on the motilin-induced anxiolytic effect. GM-109 administered alone had no effect on anxiety. These results suggest that motilin receptors are present in the brain and may have a role in anxiety and emotion.
Momose
K
K
Second Department of Internal Medicine, Kobe University School of Medicine, Japan.
Inui
A
A
Asakawa
A
A
Ueno
N
N
Nakajima
M
M
Kasuga
M
M
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001007:Anxiety / Q000378:metabolism; D001923:Brain Chemistry; D004305:Dose-Response Relationship, Drug; D006727:Hormone Antagonists / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D009037:Motilin / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D010456:Peptides, Cyclic / Q000008:administration & dosage / Q000494:pharmacology*
D014151:Anti-Anxiety Agents; C093574:GM 109; D006727:Hormone Antagonists; D010456:Peptides, Cyclic; D009037:Motilin