Rat Chromosome 2: assignment of the genes encoding cyclin B1, interleukin 6 signal transducer, and proprotein convertase 1 to the Mcs1-containing region and identification of new microsatellite markers.
The rat Chromosome (Chr) 2 harbors several genes controlling tumor growth or development, blood pressure, and non-insulin-dependent diabetes mellitus. We report that the region (2q1) containing the mammary susceptibility cancer gene Mcs1 also harbors the genes encoding cyclin B1, interleukin 6 signal transducer (gp130), and proprotein convertase 1. We also generated 13 new anonymous microsatellite markers from Chr 2-sorted DNA. These markers, as well as a microsatellite marker in the cyclin B1 gene, were genetically mapped in combination with known markers. A cyclin B1-related gene was also cytogenetically assigned to rat Chr 11q22-q23.
Szpirer
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Département de Biologie Moléculaire, Université Libre de Bruxelles, Rue des Chevaux, 67; B-1640 Rhode-Saint-Genèse, Belgium.
Tissir
F
F
Rivière
M
M
Van Vooren
P
P
Kela
J
J
Lallemand
F
F
Gabant
P
P
Hoebee
B
B
Klinga-Levan
K
K
Levan
G
G
Szpirer
J
J
D000818:Animals; D015703:Antigens, CD / Q000235:genetics*; D002874:Chromosome Mapping; D019926:Cyclin B / Q000235:genetics*; D056744:Cyclin B1; D050822:Cytokine Receptor gp130; D008040:Genetic Linkage; D017404:In Situ Hybridization, Fluorescence; D008562:Membrane Glycoproteins / Q000235:genetics*; D018895:Microsatellite Repeats; D043484:Proprotein Convertases; D051381:Rats; D029701:Saccharomyces cerevisiae Proteins; D013381:Subtilisins / Q000235:genetics*
D015703:Antigens, CD; C534701:Ccnb1 protein, rat; D019926:Cyclin B; D056744:Cyclin B1; C494201:Il6st protein, rat; D008562:Membrane Glycoproteins; D029701:Saccharomyces cerevisiae Proteins; D050822:Cytokine Receptor gp130; D043484:Proprotein Convertases; D013381:Subtilisins; C058751:KEX2 protein, S cerevisiae