title: Profiles of plasma serpins in patients with advanced malignant melanoma, gastric cancer and breast cancer.
abstract: Blood coagulation and fibrinolysis are activated systemically in patients with malignancy. The precarious balance between coagulation and fibrinolysis is modulated by serine proteinase inhibitors (serpins). Levels of selected serpins (alpha1-antichymotrypsin, alpha1-antitrypsin, alpha2-macroglobulin, antithrombin III, C1 inhibitor, alpha2-antiplasmin), substrates (factor XIIIa, fibrinogen, fibronectin) and endproducts (fibrin/fibrinogen degradation products) of coagulation reactions were measured in the plasma of 61 patients with common malignancies associated with a tendency to thrombosis (i.e. malignant melanoma, gastric cancer and breast cancer). The data revealed a heterogeneity in plasma levels of serpins between tumor types. The most profound differences between cancer and healthy subject groups were found in breast cancer patients. Levels of alpha1-antitrypsin were significantly higher and levels of alpha2-antiplasmin were significantly lower in all cancer groups, whereas there were no differences in antithrombin III levels.
authors.affiliation: Department of Oncology, Medical Academy, Bialystok, Poland.
authors.forename: M Z
authors.initials: MZ
authors.lastname: Wojtukiewicz
authors.forename: M
authors.initials: M
authors.lastname: Ruciñska
authors.forename: J
authors.initials: J
authors.lastname: Kloczko
authors.forename: A
authors.initials: A
authors.lastname: Dib
authors.forename: M
authors.initials: M
authors.lastname: Galar
mesh_terms: D000368:Aged; D001780:Blood Coagulation Tests; D001943:Breast Neoplasms / Q000097:blood*; D018270:Carcinoma, Ductal, Breast / Q000097:blood; D018275:Carcinoma, Lobular / Q000097:blood; D005260:Female; D006801:Humans; D007414:Intestinal Neoplasms / Q000097:blood; D008545:Melanoma / Q000097:blood*; D008875:Middle Aged; D015842:Serine Proteinase Inhibitors / Q000097:blood*; D015843:Serpins / Q000097:blood*; D013274:Stomach Neoplasms / Q000097:blood*
chemical_list: D015842:Serine Proteinase Inhibitors; D015843:Serpins