title: Patterns of change in growth function of distortion product otoacoustic emissions in Menière's disease.
abstract: The patterns of change in the growth function of distortion product otoacoustic emissions (DPOAEs) associated with hearing improvement in six patients with Menière's disease were investigated. The growth functions of 2F1-F2 DPOAEs at F2 frequencies of 1001, 2002 and 4004 Hz (DP-1, DP-2 and DP-4, respectively) were measured with F2 intensities ranging from 70 to 37 dBSPL in 3-dB steps. The F1 intensity was maintained 10 dB higher than the F2 intensity. The growth function was paired with the hearing threshold at the corresponding F2 frequency, and the relationships between changes in DP-1, DP-2 and DP-4 and those in hearing thresholds at 1, 2 and 4 kHz, respectively, were also investigated. The patterns of change in the growth function associated with hearing improvement could be classified into five types. In the first type, the DPOAE growth function became detectable, while the remaining four types were distinguished by combinations of changes in DPOAE amplitudes for lower and higher primary intensities. Multiple parameters, such as maximum amplitude and detection threshold of the growth function, appeared to be required for simple detection and discrimination of these patterns of change. It was also found that the DPOAE growth functions clearly changed in some cases even though the hearing thresholds did not change significantly at the corresponding F2 frequencies. This finding suggests that DPOAE growth function measurement can detect small changes in cochlear function which do not lead to changes in hearing threshold, and has higher sensitivity than pure tone audiometry in monitoring of cochlear function. In conclusion, our findings suggest that measurement of the DPOAE growth function is useful for monitoring cochlear function, and that information on its patterns of change is clinically important and useful.
authors.affiliation: Department of Otolaryngology, Osaka City University Medical School, Japan. sakashitat@med.osaka-cu.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Sakashita
authors.forename: T
authors.initials: T
authors.lastname: Kubo
authors.forename: M
authors.initials: M
authors.lastname: Kusuki
authors.forename: K
authors.initials: K
authors.lastname: Kyunai
authors.forename: K
authors.initials: K
authors.lastname: Ueno
authors.forename: C
authors.initials: C
authors.lastname: Hikawa
authors.forename: T
authors.initials: T
authors.lastname: Wada
authors.forename: T
authors.initials: T
authors.lastname: Shibata
authors.forename: Y
authors.initials: Y
authors.lastname: Nakai
mesh_terms: D000328:Adult; D001301:Audiometry, Pure-Tone; D001309:Auditory Threshold; D003051:Cochlea / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000503:physiopathology*; D008875:Middle Aged; D017084:Otoacoustic Emissions, Spontaneous