[Endothelial damage and blood coagulation activation in preeclampsia].
BACKGROUND
The aim of this study was the evaluation of the endothelial cell damage and of the likely activation of coagulative cascade in preeclampsia.


METHODS
Forty-seven pregnant women of gestational age from 30 to 34 weeks of gestation were studied: 30 normal pregnancies (N) and 17 women suffering from preeclampsia (P). The plasma factors studied were the following: 1) plasma fibronectin and thrombomodulin as markers of endothelial cell damage; 2) beta-thromboglobulin as platelet activity markers; 3) VIII:C factor and fibrinopeptide A as coagulation activity markers; 4) coagulation inhibitors such as protein C and protein S activity; 5) tissue plasminogen activator (t-PA), plasminogen level and plasminogen activator inhibitors (PAI) as fibrinolytic activity markers. All hypertensive patients didn't use heparin. Data are presented as mean +/- 1SD. Mann-Whitney "U" -test was used for statistical analysis. A p value of < or = 0.05 was regarded as statistically significant.


RESULTS
In preeclampsia the plasma fibronectin is increased (P: 115 +/- 64 ng/ml, N: 73 +/- 47 ng/ml; p = 0.023) as well as VIII:C factor activity (P: 151 +/- 13.5%, N: 117.2 +/- 23%; p = 0.0005).


CONCLUSIONS
Endothelial cell damage (increase of plasma fibronectin) and a slight thrombin generation (increase of VIII:C factor activity) are to be found in preeclampsia. We can't say which event starts the process. Intravascular coagulative cascade activation with platelet consumption, fibrin production and fibrinolytic activation occurs only in a restricted number of preeclamptic patients, in a late and worsening stage of illness, as a consequence of massive endothelial damage at placental and systemic level.
Stella
A
A
Istituto di Ginecologia ed Ostetricia, Università degli Studi, Padova.
Babbo
G L
GL
Grella
P V
PV
D000328:Adult; D001777:Blood Coagulation; D004727:Endothelium / Q000098:blood supply / Q000473:pathology*; D005260:Female; D005353:Fibronectins / Q000097:blood; D005865:Gestational Age; D006801:Humans; D010960:Plasminogen Activators / Q000097:blood; D015849:Plasminogen Inactivators / Q000097:blood; D011225:Pre-Eclampsia / Q000097:blood / Q000503:physiopathology*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third
D005353:Fibronectins; D015849:Plasminogen Inactivators; D010960:Plasminogen Activators