Lymphomatoid granulomatosis of the lung: a clinico-pathological study.
Lymphomatoid granulomatosis is the only form of pulmonary angiitis histologically characterized by a necrotizing angiocentric and angiodestructive lymphoid infiltrate, with an admixed T-cell reaction. We evaluated three patients with a single lung nodule not diagnosed by routine radiological and endoscopic assays. Our investigations showed a prevalence of T-cells in areas of diffuse infiltration, which were actively replacing reactive follicular areas of B-cells, similarly to T-cell lymphomas. Further pathologic assays suggested the histologic diagnosis of grade I lymphomatoid granulomatosis for all three evaluated specimens. After two years, patients treated with a combination of surgical resection and chemotherapy were disease free, supporting the efficacy of aggressive therapy in the management of this often mistreated group of lymphoid proliferations.
Baldi
A
A
Università Campus Bio-Medico, Roma, Italy.
Groeger
A M
AM
Esposito
V
V
Di Lieto
E
E
Di Marino
M P
MP
Santini
D
D
Baldi
F
F
D015703:Antigens, CD / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000627:therapeutic use; D018572:Disease-Free Survival; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology / Q000473:pathology; D008230:Lymphomatoid Granulomatosis / Q000188:drug therapy / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology; D013997:Time Factors
D015703:Antigens, CD; D002945:Cisplatin