title: Pentoxifylline and skin inflammation.
abstract: Cyclic nucleotide phosphodiesterase inhibitors, such as pentoxifylline, have been shown to beneficially influence a large number of inflammatory skin diseases. The biological effects of pentoxifylline on the production of proinflammatory cytokines, leukocyte-endothelial cell adhesion, chemokines and leukocyte-keratinocyte adhesion in skin inflammation are discussed.
authors.affiliation: Department of Dermatology, Free University Hospital, Amsterdam, The Netherlands.
authors.forename: I
authors.initials: I
authors.lastname: Bruynzeel
authors.forename: T J
authors.initials: TJ
authors.lastname: Stoof
authors.forename: R
authors.initials: R
authors.lastname: Willemze
mesh_terms: D002448:Cell Adhesion / Q000187:drug effects; D016207:Cytokines / Q000096:biosynthesis; D003872:Dermatitis / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D010431:Pentoxifylline / Q000627:therapeutic use*; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use*
chemical_list: D016207:Cytokines; D010726:Phosphodiesterase Inhibitors; D010431:Pentoxifylline