[Study of offsprings of survivors of childhood malignant diseases].
Anthropometric, dysmorphologic, and cytogenetic investigations of 21 children of 20 survivors of childhood malignancy revealed no signs of congenital anomalies in any of the subjects examined. No increase of mild errors of morphogenesis (minor anomalies) was observed in the well-developing children; no latent chromosome instability was found in their Bleomycin-treated lymphocyte cultures either. The suggestion that previous oncological therapy does not lead to an increased risk of congenital disorders in the offspring was confirmed by the present findings obtained with various, in part new methods.
Méhes
K
K
Pésci Orvostudományi Egyetem, Gyermekklinika.
Szücs
R
R
Khezri
S
S
Kajtár
P
P
Bajnóczky
K
K
Kosztolányi
G
G
D000886:Anthropometry; D001761:Bleomycin / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D003582:Cytogenetics; D005260:Female; D006801:Humans; D007223:Infant; D007959:Lymphocyte Culture Test, Mixed / Q000379:methods; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D009024:Morphogenesis; D009369:Neoplasms / Q000151:congenital / Q000235:genetics*; D017741:Survivors
D001761:Bleomycin