Studies on the biological activity of the dermal regeneration template.
In mammals, the skin normally responds to injury by the processes of wound contraction and scar formation. However, if a unique acellular dermal regeneration template is placed into the wound, wound contraction is strongly inhibited, and the skin undergoes a regenerative-type healing. It is proposed that these phenomena result from the disruption of a "mechanically coherent" organization of myofibroblasts within the wound. Evidence suggests that the dermal regeneration template prevents the formation of cell-extracellular matrix interactions (fibronexi), which foster the assemblage of a mechanically coherent wound bed. Additional studies support a similar mechanism for the enhanced regenerative-like response to peripheral nerves when extracellular matrix tubes are used to facilitate healing.
Yannas
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Departments of Mechanical Engineering and Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Mass 02139-4307, USA.
D000328:Adult; D000818:Animals; D002921:Cicatrix / Q000503:physiopathology / Q000517:prevention & control*; D003286:Contracture / Q000503:physiopathology / Q000517:prevention & control*; D005109:Extracellular Matrix / Q000502:physiology; D005347:Fibroblasts / Q000502:physiology*; D006801:Humans; D009416:Nerve Regeneration / Q000502:physiology*; D012879:Skin Physiological Phenomena; D013698:Templates, Genetic; D014945:Wound Healing / Q000502:physiology*