title: Multiple cutaneous metastases as the first sign of lung cancer in a patient with well-differentiated papillary transitional cell carcinoma of the urinary bladder.
abstract: A case of multiple, cutaneous metastases as the first sign of lung cancer in a patient with well-differentiated, papillary, transitional cell carcinoma of the urinary bladder is presented. In the left clavicular region were two, sharply demarcated, dark red tumors measuring 3 and 2 cm in diameter with a history of rapid growth and intermittent spontaneous bleeding. Thorough examination of the patient revealed 16 additional skin lesions, which were dark red macules and papules, 2-3 mm in diameter, situated on the left side of the chest. The skin biopsy material (tumors, macular and papular lesions) was studied using histological and immunohistochemical techniques and showed intact epidermis and massive dermal and subcutaneous metastatic involvement by a small cell carcinoma with neuroendocrine differentiation most likely originating in the lung.
authors.affiliation: St. Martin's University Hospital, Jessenius Faculty of Medicine, Comenius University, Kollarova 2, 036 59 Martin, SK - Slovak Republic.
authors.forename: J
authors.initials: J
authors.lastname: Pec
authors.forename: L
authors.initials: L
authors.lastname: Plank
authors.forename: J
authors.initials: J
authors.lastname: Kliment
authors.forename: J
authors.initials: J
authors.lastname: Luptak
authors.forename: E
authors.initials: E
authors.lastname: Hajtmanova
authors.forename: M
authors.initials: M
authors.lastname: Pec
mesh_terms: D000368:Aged; D001707:Biopsy, Needle; D018288:Carcinoma, Small Cell / Q000175:diagnosis* / Q000556:secondary*; D002295:Carcinoma, Transitional Cell / Q000473:pathology / Q000601:surgery; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000175:diagnosis*; D008297:Male; D009378:Neoplasms, Multiple Primary; D012878:Skin Neoplasms / Q000175:diagnosis / Q000556:secondary*; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000601:surgery