title: [Hepatobiliary clearance of glycocholic acid in Gilbert's disease].
abstract: OBJECTIVE
  To research the behaviour of one biliary acid (glyco-cholic) i.v. injected in patients with Gilbert's disease and in healthy controls, so that contribute to the knowledge of the pathophysiological correlate between bilirubin and biliary acids.
  
  
  METHODS
  We include 15 patients with Gilbert's disease and 7 healthy voluntary ones. We injected i.v. glycocholic acid and obtained the clearance curve (CG-RIA Abbot method). We evaluated the possible biostatistically significant differences between the obtained values of both groups though the non-parametric method of Mann-Whitney.
  
  
  RESULTS
  The clearance curve of both groups had a similar profile; biostatisticaly there are not significant differences between the serum values of glyco-cholic acid in both groups.
  
  
  CONCLUSIONS
  The clearance of the glyco-cholic acid in patients with Gilbert's disease had a similar behaviour as in healthy controls, without biostatisticaly significant differences between both groups.
authors.affiliation: Servicio de Medicina Interna (Grupo de Estudio Hepatobiliar), Hospital Clínico y Facultad de Medicina, Universitat de València.
authors.forename: I
authors.initials: I
authors.lastname: Serna Miquel
authors.forename: R
authors.initials: R
authors.lastname: Bataller Sifré
authors.forename: R
authors.initials: R
authors.lastname: Bataller Alberola
authors.forename: J L
authors.initials: JL
authors.lastname: Moreno Frígols
mesh_terms: D001646:Bile / Q000378:metabolism; D002756:Cholagogues and Choleretics / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005878:Gilbert Disease / Q000378:metabolism*; D006000:Glycocholic Acid / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007275:Injections, Intravenous; D008099:Liver / Q000378:metabolism
chemical_list: D002756:Cholagogues and Choleretics; D006000:Glycocholic Acid