Dietary fat and breast cancer: a brief update on current knowledge.
Descriptive epidemiologic data suggest a relationship between consumption of high fat diets and breast cancer; although these data can be potentially confounded by other causative exposures. Results of published case-control and cohort studies are inconclusive. Nevertheless, dietary fat significantly affects mammary tumorigenesis in mice and rats in laboratory experiments. We will review current epidemiologic and animal studies, explain the possible mechanisms of how dietary fat may affect breast cancer, and provide preliminary dietary recommendations.
Santiago
E
E
Department of Human Development, Graduate School of Public Health, University of Puerto Rico, San Juan, PR 00936-5067.
González
M J
MJ
Matos
M I
MI
Pérez
C M
CM
D000328:Adult; D000367:Age Factors; D000818:Animals; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000378:metabolism / Q000517:prevention & control; D016022:Case-Control Studies; D015331:Cohort Studies; D003627:Data Interpretation, Statistical; D004041:Dietary Fats / Q000009:adverse effects*; D002149:Energy Intake; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D051379:Mice; D008875:Middle Aged; D017698:Postmenopause; D017697:Premenopause; D011453:Prostaglandins / Q000096:biosynthesis; D051381:Rats; D012307:Risk Factors
D004041:Dietary Fats; D011453:Prostaglandins