Dexamethasone-induced hepatomegaly in three children.
High-dose treatment with dexamethasone led to reversible hepatomegaly with disturbance of liver function in three children. After withdrawal of dexamethasone, liver size and function returned to normal. These observations were compared with previously published data. The authors conclude that if this condition occurs, dexamethasone should be discontinued.
Verrips
A
A
Department of Paediatric Neurology, University Hospital Nijmegen, The Netherlands.
Rotteveel
J J
JJ
Lippens
R
R
D002648:Child; D002675:Child, Preschool; D003907:Dexamethasone / Q000009:adverse effects*; D005260:Female; D006529:Hepatomegaly / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D007223:Infant; D008297:Male; D013163:Splenomegaly / Q000139:chemically induced / Q000188:drug therapy; D016896:Treatment Outcome
D003907:Dexamethasone