title: Anterior rhinomanometry in nasal allergen challenges.
abstract: Even simple and relatively safe provocation procedures like nasal allergen challenges, should aim to allow detection of positivity with the less possible discomfort to the patient. The objective of this work was to evaluate if the use of rhinomanometric measurements during nasal provocation procedures could allow a decrease in the total administered allergen dose, causing less symptoms to the patients but without increasing the number of false-negatives, comparatively to clinical scores or nasal peak-flow measurements. Our results showed that performing rhinomanometric measurements during nasal HDM challenge procedures can lead in many patients to a reduction in the total dose of allergen administered during the challenge, without loss of sensitivity or specificity. This allergen dose reduction translates in less time consumed during the provocation and less patients' discomfort.
authors.affiliation: Immunoallergology Unit, Hospital Santa Maria, Lisbon, Portugal.
authors.forename: M B
authors.initials: MB
authors.lastname: Ferreira
authors.forename: A G
authors.initials: AG
authors.lastname: Carlos
mesh_terms: D000328:Adult; D000403:Airway Resistance; D000485:Allergens / Q000008:administration & dosage; D004306:Dose-Response Relationship, Immunologic; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry / Q000379:methods*; D009296:Nasal Cavity / Q000503:physiopathology*; D009299:Nasal Provocation Tests / Q000379:methods*; D010366:Peak Expiratory Flow Rate; D012221:Rhinitis, Allergic, Perennial / Q000175:diagnosis* / Q000503:physiopathology; D006255:Rhinitis, Allergic, Seasonal / Q000175:diagnosis* / Q000503:physiopathology; D012680:Sensitivity and Specificity
chemical_list: D000485:Allergens