title: In search of novel water soluble forskolin analogues for positive inotropic activity.
abstract: Using the novel lead from hydroxy acetyl substituted forskolin analogues, such as 7 beta-hydroxyacetyl-7 beta-deacetyl forskolin or 6 beta-hydroxyacetyl forskolin, a number of water soluble omega-amino acyl derivatives were synthesized. Two such compounds 6 and 18 showed better in vitro activity but failed to show in vivo activity.
authors.affiliation: Department of Chemistry, Hoechst Marion Roussel Limited, Mumbai, India. bansilal@hoechstres.rpgms.ems.vsnl.net.in
authors.forename: B
authors.initials: B
authors.lastname: Lal
authors.forename: A K
authors.initials: AK
authors.lastname: Gangopadhyay
authors.forename: R M
authors.initials: RM
authors.lastname: Gidwani
authors.forename: M
authors.initials: M
authors.lastname: Fernandes
authors.forename: R
authors.initials: R
authors.lastname: Rajagopalan
authors.forename: A V
authors.initials: AV
authors.lastname: Ghate
mesh_terms: D000107:Acetylation; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002415:Cats; D005576:Colforsin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects / Q000502:physiology; D006325:Heart Atria; D006900:Hydroxylation; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology; D012995:Solubility; D013329:Structure-Activity Relationship; D014867:Water
chemical_list: D007202:Indicators and Reagents; D014867:Water; D005576:Colforsin