The application of strong cation exchange high-performance liquid chromatography to drug analysis.
The application of strong cation exchange (SCX) HPLC to the analysis of drugs in plasma, tissue and rodent feed is presented. This approach is shown to give useful separations allowing the separation of physiochemically diverse compounds in a simple isocratic system. The SCX columns are not as robust as standard reversed-phase materials and to ensure maximum column lifetimes the use of a guard column is recommended.
Law
B
B
Zeneca Pharmaceuticals, Macclesfield, Cheshire, UK. brian.law@alderley.zeneca.com
Appleby
J R
JR
D000821:Animal Feed / Q000032:analysis; D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000032:analysis*; D051381:Rats
D004364:Pharmaceutical Preparations