title: Development of CD4+ effector T cells and susceptibility to infectious diseases.
abstract: The mechanisms by which naive helper T cells differentiate into potent cytokine-expressing effectors remain critical to understanding both successful and aberrant immune responses. Studies using Leishmania major infection of mice have revealed genetic contributions to factors that influence this differentiative process. Further, antigen recognition at the level of the T cell repertoire can also profoundly affect the outcome of disease and the appearance of discrete T cell subsets. It is likely that such mechanisms also underpin genetic susceptibility to diverse other infectious and autoimmune diseases.
authors.affiliation: Department of Medicine, University of California, San Francisco 94143-0654, USA. rich_locksley@quickmail.ucsf.edu
authors.forename: R M
authors.initials: RM
authors.lastname: Locksley
authors.forename: D J
authors.initials: DJ
authors.lastname: Fowell
authors.forename: K
authors.initials: K
authors.lastname: Shinkai
authors.forename: A E
authors.initials: AE
authors.lastname: Wakil
authors.forename: D
authors.initials: D
authors.lastname: Lacy
authors.forename: M
authors.initials: M
authors.lastname: Bix
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D003141:Communicable Diseases / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D004198:Disease Susceptibility / Q000276:immunology; D051379:Mice