title: Clinical analysis of the prognostic value of ultrastructural abnormalities of plasma cells in patients with multiple myeloma.
abstract: The prognostic value of ultrastructural abnormalities of plasma, cells was analyzed in 61 patients with multiple myeloma treated in our hospitals from 1985 to 1996. The survival curves demonstrated significant differences by stratification of ultrastructural abnormalities, such as irregular contour of the nuclear membrane, nuclear body, budding, disarrangement of organelles, fibrillar formation, intramitochondrial granules, multilamellar body, single-sac loop-like structure, and vacuole. However, categorizing by nuclear inclusion body, cytoplasmic inclusion body and dense body showed no significant difference in survival curves. Abnormalities, as well as maturity, may be useful in predicting the prognosis of myeloma patients.
authors.affiliation: Department of Medicine, Kusatsu Branch Hospital, Gunma University Hospital, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kurabayashi
authors.forename: K
authors.initials: K
authors.lastname: Kubota
authors.forename: J
authors.initials: J
authors.lastname: Tamura
authors.forename: T
authors.initials: T
authors.lastname: Naruse
authors.forename: H
authors.initials: H
authors.lastname: Murakami
authors.forename: J
authors.initials: J
authors.lastname: Tsuchiya
mesh_terms: D001854:Bone Marrow Cells / Q000648:ultrastructure; D002467:Cell Nucleus / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009101:Multiple Myeloma / Q000401:mortality / Q000473:pathology*; D015388:Organelles / Q000648:ultrastructure; D010950:Plasma Cells / Q000648:ultrastructure*; D011379:Prognosis; D015996:Survival Rate