[Fulminant hepatic failure related to immunosuppressive therapy in an asymptomatic HBsAg carrier with idiopathic interstitial pneumonia].
A 72-year-old woman who was an asymptomatic HBsAg carrier was admitted because of productive cough and dyspnea on exertion. After close examination, she was given a diagnosis of idiopathic interstitial pneumonia (IIP), and treated with glucocorticoids and cyclophosphamide. However, fulminant hepatitis type B developed and the patient died of respiratory complications stemming from the acute exacerbation of IIP. To avoid such outcomes, extra caution should be taken when planning immunosuppressive therapy for HBsAg carriers.
Takagi
S
S
First Department of Internal Medicine, Yokohama City University School of Medicine, Japan.
Nishikawa
M
M
Suzuki
M
M
Miyashita
A
A
Hashizume
T
T
Kakemizu
N
N
Ikeda
H
H
Suzuki
S
S
Okubo
T
T
D000368:Aged; D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D002353:Carrier State; D003520:Cyclophosphamide / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D006509:Hepatitis B / Q000209:etiology*; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D017093:Liver Failure / Q000209:etiology; D017563:Lung Diseases, Interstitial / Q000150:complications / Q000188:drug therapy*; D011239:Prednisolone / Q000009:adverse effects; D012131:Respiratory Insufficiency / Q000209:etiology
D000893:Anti-Inflammatory Agents; D006514:Hepatitis B Surface Antigens; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D011239:Prednisolone