Estrogens and postprandial lipid metabolism.
Women with angiographically proven coronary heart disease (CAD) had higher postprandial concentrations of small chylomicron-remnants, measured as IDL apo B48, than women without CAD. Fasting TG concentrations were not different and within the normal range. Thus, the postprandial concentration of small chylomicron-remnants could identify women at high CAD risk within a normolipidemic population. Replacement therapy with 17beta-estradiol improved the clearance of chylomicron-remnants by 41% and attenuated the postprandial reduction in HDL-cholesterol by 66%. This improvement in postprandial lipid metabolism can explain part of the protective effect of estrogens against CAD.
Westerveld
H E
HE
Department of Internal Medicine, Academic Hospital Utrecht, The Netherlands. h.e.westerveld@digd.azu.nl
D000328:Adult; D002914:Chylomicrons / Q000097:blood*; D003327:Coronary Disease / Q000097:blood* / Q000503:physiopathology; D004958:Estradiol / Q000008:administration & dosage*; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D050356:Lipid Metabolism; D008875:Middle Aged; D017698:Postmenopause; D019518:Postprandial Period
D002914:Chylomicrons; D004958:Estradiol