[Single-chamber atrial pacing is better than single chamber ventricular pacing in patients with sick sinus syndrome. Results of long-term follow up in a prospective randomized study].
In a study of 225 patients with sick sinus syndrome randomized to single chamber atrial pacing (n = 110) or ventricular pacing (n = 115), atrial pacing was associated with less atrial fibrillation and thromboembolism after 3.3 years follow-up. To determine whether this beneficial effect of atrial pacing is maintained at long-term, follow-up was extended. Follow-up visits were at 3 months, 12 months, and then once every year, and included physical examination, ECG, and pacemaker check-up. After 5.5 years follow-up, all-cause mortality, cardiovascular deaths, atrial fibrillation, thromboembolism, and heart failure were significantly less in the atrial group. AV block occurred in four patients in the atrial group. The beneficial effect of atrial pacing observed previously is enhanced substantially after extended follow-up. Patients with sick sinus syndrome should be treated with an atrial pacing system.
Nielsen
J C
JC
Arhus Universitetshospital, Skejby Sygehus, hjertemedicinsk afdeling B.
Mortensen
P T
PT
Thuesen
L
L
Nielsen
T V
TV
Thomsen
P E
PE
Pedersen
A K
AK
Andersen
H R
HR
D000368:Aged; D001281:Atrial Fibrillation / Q000175:diagnosis / Q000209:etiology; D002304:Cardiac Pacing, Artificial / Q000379:methods* / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D008297:Male; D010138:Pacemaker, Artificial; D011379:Prognosis; D011446:Prospective Studies; D012804:Sick Sinus Syndrome / Q000150:complications / Q000628:therapy*; D013923:Thromboembolism / Q000175:diagnosis / Q000209:etiology