Lipid peroxidation in experimental ischemia of the brain.
Lipid peroxidation was studied in the brain of Mongolian gerbils under conditions of complete ischemia followed by recirculation in the left hemisphere without recirculation in the right hemisphere. Thiobarbituric acid reactive products and the intensity of Fe2+-induced chemiluminescence were determined. The content of lipid peroxidation products in the brain tissue was increased not only under conditions of recirculation, but also at the ischemia stage during the limited access of oxygen. Thus, the destructive effect of free radicals may occur even during the early stage of ischemic injury of the brain.
Fedorova
T N
TN
Institute of Neurology, Russian Academy of Medical Sciences, Moscow, 123367, Russia. aab@bio.inevro.msk.ru
Boldyrev
A A
AA
Gannushkina
I V
IV
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001921:Brain / Q000378:metabolism*; D002545:Brain Ischemia / Q000378:metabolism*; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D004195:Disease Models, Animal; D005260:Female; D005849:Gerbillinae; D015227:Lipid Peroxidation / Q000502:physiology*; D008163:Luminescent Measurements; D008297:Male; D015424:Reperfusion; D013858:Thiobarbiturates / Q000378:metabolism