Hormonal replacement therapy in menopausal women with a history of hyperprolactinemia.
Hyperprolactinemia is involved in almost 30% of infertility problems. At the onset of menopause, prolactin levels often decrease; however, no data are available regarding the course of hyperprolactinemia after menopause with hormonal replacement therapy (HRT). A retrospective study was undertaken in our department to evaluate the potential role of estrogens in women with a history of hyperprolactinemia. Twenty-two patients, with hyperprolactinemia before menopause, were followed-up. Group I included 11 patients who withdrew bromocriptine treatment when menopause was confirmed. These patients were placed on HRT with no other medication administered. HRT was a combination of percutaneous estradiol gel and an oral progestin. Group II included 7 women treated by bromocriptine before menopause and after menopause concomitantly with HRT. Group III included 4 patients who did not receive HRT or other treatments once menopause was diagnosed. The mean serum prolactin level was unchanged in Group I (22.8+/-21.7 before and 22.8+/-16.1 ng/ml after HRT) while it increased but not significantly from 8.1+/-5.2 to 16.0+/-11.7 ng/ml in Group II. The mean duration of HRT was 42.8+/-23.8 (7-81) and 37.3+/-31.0 (6-99) months in Group I and II respectively. In Group III patients, PRL levels decreased spontaneously from 61.2+/-39.8 to 33.0+/-34.7 ng/ml. In conclusion, in this population of menopausal patients with a history of moderate hyperprolactinemia, HRT did not seem to affect plasma prolactin levels.
Touraine
P
P
Department of Endocrinology and Reproductive Medicine, Hôpital Necker, Paris, France.
Deneux
C
C
Plu-Bureau
G
G
Mauvais-Jarvis
P
P
Kuttenn
F
F
D000236:Adenoma / Q000000981:diagnostic imaging; D000328:Adult; D001971:Bromocriptine / Q000627:therapeutic use; D004958:Estradiol / Q000008:administration & dosage; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood* / Q000188:drug therapy; D008593:Menopause; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000000981:diagnostic imaging; D011372:Progestins / Q000008:administration & dosage; D011388:Prolactin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone; D014057:Tomography, X-Ray Computed