title: Prevalence of IgG antibodies to Ebola virus in individuals during an Ebola outbreak, Democratic Republic of the Congo, 1995.
abstract: During the 1995 outbreak of Ebola (EBO) hemorrhagic fever in Kikwit, Democratic Republic of Congo, two surveys using a new ELISA for EBO (subtype Zaire) virus antigen were conducted to assess the prevalence of EBO IgG antibodies among residents of Kikwit and the surrounding area. The first study determined the proportion of antibody-positive individuals who were self-identified forest and city workers from the Kikwit area. Serum samples from 9 (2.2%) of 414 workers had IgG EBO antibodies. The second study determined the proportion of EBO antibody-positive individuals who lived in villages surrounding Kikwit. The prevalence of IgG EBO antibodies in this population was 9.3% (151161). The difference in the overall prevalence of EBO antibodies may indicate that villagers have a greater chance of exposure to EBO virus compared with those living in and in close proximity to cities.
authors.affiliation: Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
authors.forename: K M
authors.initials: KM
authors.lastname: Busico
authors.forename: K L
authors.initials: KL
authors.lastname: Marshall
authors.forename: T G
authors.initials: TG
authors.lastname: Ksiazek
authors.forename: T H
authors.initials: TH
authors.lastname: Roels
authors.forename: Y
authors.initials: Y
authors.lastname: Fleerackers
authors.forename: H
authors.initials: H
authors.lastname: Feldmann
authors.forename: A S
authors.initials: AS
authors.lastname: Khan
authors.forename: C J
authors.initials: CJ
authors.lastname: Peters
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D015023:Democratic Republic of the Congo / Q000453:epidemiology; D004196:Disease Outbreaks; D029043:Ebolavirus / Q000276:immunology*; D005260:Female; D016468:Forestry; D019142:Hemorrhagic Fever, Ebola / Q000453:epidemiology* / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D009790:Occupations; D012424:Rural Population; D014505:Urban Population