title: Increased karyotype precision using fluorescence in situ hybridization and spectral karyotyping in patients with myeloid malignancies.
abstract: We studied seven patients with various malignant hematologic disorders using fluorescence in situ hybridization (FISH) and one of these patients with spectral karyotyping (SKY). With appropriate probes, the t(8;21) and inv(16) were confirmed in two patients and the karyotypic precision was increased in five others using FISH and SKY. Two of three patients with 12p rearrangements had a deletion of one TEL allele. Thus, these newer techniques are an important adjunct to accurate chromosome analysis in malignancy.
authors.affiliation: Cancer Research Center, Moscow, Russia.
authors.forename: E W
authors.initials: EW
authors.lastname: Fleischman
authors.forename: S
authors.initials: S
authors.lastname: Reshmi
authors.forename: O I
authors.initials: OI
authors.lastname: Sokova
authors.forename: O P
authors.initials: OP
authors.lastname: Kirichenko
authors.forename: L N
authors.initials: LN
authors.lastname: Konstantinova
authors.forename: O E
authors.initials: OE
authors.lastname: Kulagina
authors.forename: M A
authors.initials: MA
authors.lastname: Frenkel
authors.forename: J D
authors.initials: JD
authors.lastname: Rowley
mesh_terms: D000293:Adolescent; D000328:Adult; D002871:Chromosome Banding; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000592:standards*; D007621:Karyotyping / Q000379:methods*; D007951:Leukemia, Myeloid / Q000235:genetics*; D008297:Male; D008875:Middle Aged