title: [99mTc pertechnetate scintigraphy and premedication for the search for ectopic gastric mucosa in Meckel's diverticulum].
abstract: BACKGROUND
  Meckel's diverticulum (MD) is the most common anomaly of the large intestinal tract (1-3%) and is more frequent in children (62% < 2 years) and in males (66%). It often involves ectopic gastric mucosa which manifests through gastrointestinal bleeding in 50% of cases. 99m-Technetium scintigraphy (99mTcO4) is one of the procedures available for the non-invasive diagnosis of ectopic gastric mucosa.
  
  
  METHODS
  Twenty-eight patients (11 females, 17 males), including 16 children and 12 adults, aged 8 months-80 years old, were included in the study. The patients were admitted to hospital for hematochezia and melena (22) associated with abdominal pain (5): 3 patients repeatedly presented occult blood in their stools. Two patients only suffered from abdominal cramps and one only anemia. Patients were studied using plain abdominal radiographs and ultrasound; 10 underwent gastroscopy and colonoscopy; radiological contrast studies were performed in 5 patients. All tests were inconclusive. All the patients were premedicated with oral cimetidine (20 mg/kg in pediatric patients and 300 mg q.i.d. for adults, 48 hours before the test) or with ranitidine i.v. (1 mg/kg, max 50 mg, in 20 minutes, one hour before the test); barium meals and colonoscopy were deferred for 2-3 days after examination. An intravenous injection of 37-180 Mbq of 99mTcO4 was given followed by a dynamic study of the abdomen in anterior projection. Images were acquired for one hour or until the visualisation of abnormal foci of intake: in this case, lateral and oblique images were acquired for a better localisation of the suspicious area. Some patients were administered furosemide i.v. (0.75 mg/kg). All underwent a follow-up period of 12 months.
  
  
  RESULTS
  Pertechnetate scintigraphy was positive in 10 cases and the presence of ectopic gastric mucosa was confirmed by surgery. The study was negative in 18 cases: 3 of them were discharged with a diagnosis of Salmonella infection, polyp of the small bowel or ulcer of the large bowel respectively; the other 15 patients did not show symptoms of onset during follow-up.
  
  
  CONCLUSIONS
  These results confirm the high diagnostic accuracy of pertechnetate scintigraphy to detect ectopic gastric mucosa if associated with H2-receptor-blocking agent premedication.
authors.affiliation: Azienda Ospedaliera, Servizio di Medicina Nucleare I, Università degli Studi, Padova.
authors.forename: L
authors.initials: L
authors.lastname: Rampin
authors.forename: D
authors.initials: D
authors.lastname: Donner
authors.forename: P
authors.initials: P
authors.lastname: Zucchetta
authors.forename: M
authors.initials: M
authors.lastname: Zuffante
authors.forename: P
authors.initials: P
authors.lastname: Faggin
authors.forename: F
authors.initials: F
authors.lastname: Bui
authors.forename: M
authors.initials: M
authors.lastname: Gregianin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D002828:Choristoma / Q000000981:diagnostic imaging*; D002927:Cimetidine / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D005260:Female; D005753:Gastric Mucosa; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D007077:Ileal Diseases / Q000000981:diagnostic imaging*; D007223:Infant; D008297:Male; D008467:Meckel Diverticulum / Q000000981:diagnostic imaging*; D008875:Middle Aged; D011292:Premedication; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D011899:Ranitidine / Q000627:therapeutic use*; D012189:Retrospective Studies; D013670:Sodium Pertechnetate Tc 99m