Clomiphene citrate challenge test: cycle to cycle variability of cycle day 10 follicle stimulating hormone level.
The clomiphene citrate challenge test (CCCT), a means of assessing ovarian reserve, was shown by several studies to have an excellent predictive value for achieving conception in natural cycles, during ovulation induction and in-vitro fertilization cycles. Accordingly we elected to study the cycle to cycle variability of CCCT so as to determine the reliability of a single CCCT result. Two groups of patients were studied, the first (n = 40) were those patients who were performing the test because it was indicated, and the second (n = 24) were those who were receiving clomiphene citrate for ovulation induction. In both groups CCCT intercycle variability was significant in 75% of the cases, but this variability altered the prognostic values of the test in only 40% of the first group. In conclusion, our study showed a high percentage of intercycle variability of CCCT but further studies are needed to evaluate the influence of this variability on potential conception.
Hannoun
A
A
Department of Obstetrics and Gynecology, American University of Beirut, Medical Centre, Lebanon.
Abu Musa
A
A
Awwad
J
J
Kaspar
H
H
Khalil
A
A
D000328:Adult; D002996:Clomiphene; D005260:Female; D005300:Fertility Agents, Female; D005306:Fertilization; D015200:Fluoroimmunoassay; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D008597:Menstrual Cycle / Q000378:metabolism*; D010050:Ovarian Function Tests; D011237:Predictive Value of Tests