title: Synthesis and antituberculosis activity of new 2-quinoxalinecarbonitrile 1,4-di-N-oxides.
abstract: With the advent of multidrug-resistant Mycobacterium tuberculosis strains, new and effective therapies are rapidly needed to combat infections caused by these strains. Some new 2-quinoxalinecarbonitrile 1,4-di-N-oxides have been synthesized and tested as antituberculosis agents and interesting results have been obtained from the first screening.
authors.affiliation: Centro de Investigación en Farmacobiología Aplicada, Universidad de Navarra, España.
authors.forename: M A
authors.initials: MA
authors.lastname: Ortega
authors.forename: Y
authors.initials: Y
authors.lastname: Sainz
authors.forename: M E
authors.initials: ME
authors.lastname: Montoya
authors.forename: A
authors.initials: A
authors.lastname: López De Ceráin
authors.forename: A
authors.initials: A
authors.lastname: Monge
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D012293:Rifampin / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship