title: Neoplastic transformation-associated stimulation of the in vitro resolution of concatemer junction fragments from minute virus of mice DNA.
abstract: Minute virus of mice (MVM) shows an oncotropic behavior reflected by its ability to amplify its genome more efficiently in a number of transformed versus normal cells. In vivo and in vitro studies revealed that the major effect of cell transformation on MVM DNA replication occurs at the level of double-stranded replicative-form amplification. In particular, resolution of MVM DNA concatemers into monomers was found to be highly sensitive to neoplastic transformation.
authors.affiliation: Deutsches Krebsforschungszentrum, Department of Applied Tumor Virology, Abt. F0100 and Formation INSERM U375, Heidelberg, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Kuntz-Simon
authors.forename: T
authors.initials: T
authors.lastname: Bashir
authors.forename: J
authors.initials: J
authors.lastname: Rommelaere
authors.forename: K
authors.initials: K
authors.lastname: Willwand
mesh_terms: D002471:Cell Transformation, Neoplastic; D004261:DNA Replication; D004279:DNA, Viral / Q000737:chemistry*; D005784:Gene Amplification; D006801:Humans; D008915:Minute Virus of Mice / Q000235:genetics*; D014779:Virus Replication