How do tetracyclines work?
This paper is a summary of a panel discussion by the following panelists: L. Golub, J. te Koppele, G. Nieman, M. Nelson, R. Ashley, T. Sorsa, and S. Simon. The panel discussed the mechanisms by which the tetracyclines and their non-antimicrobial counterparts may provide therapeutic efficacy in a variety of chronic and acute diseases.
Ryan
M E
ME
State University of New York, Stony Brook, Department of Oral Biology & Pathology, School of Dental Medicine, Health Sciences Center, Stony Brook 11794-8702, USA.
Ashley
R A
RA
D000328:Adult; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D004357:Drug Synergism; D006801:Humans; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors; D010010:Osteoclasts / Q000187:drug effects; D011480:Protease Inhibitors / Q000494:pharmacology*; D012128:Respiratory Distress Syndrome / Q000188:drug therapy; D013754:Tetracyclines / Q000494:pharmacology* / Q000627:therapeutic use