Involvement of MLL gene in a t(10;11)(q22;q23) and a t(8;11)(q24;q23) identified by fluorescence in situ hybridization.
We describe two cases of acute myeloblastic leukemia, classified as M4 and M5 in the French-American-British nomenclature, with an 11q23 rearrangement at karyotypic analysis. The involvement of the MLL gene with two new partner loci on chromosome 10q22 and 8q24, respectively, was demonstrated by fluorescence in situ hybridization using a YAC clone B22B2L.
Aventín
A
A
Institute of Hematology, University of Perugia, Italy.
La Starza
R
R
Martínez
C
C
Wlodarska
I
I
Boogaerts
M
M
Van den Berghe
H
H
Mecucci
C
C
D000328:Adult; D001752:Blast Crisis; D001853:Bone Marrow / Q000473:pathology; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10; D002880:Chromosomes, Human, Pair 11; D002898:Chromosomes, Human, Pair 8; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D007948:Leukemia, Monocytic, Acute / Q000097:blood / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D015479:Leukemia, Myelomonocytic, Acute / Q000097:blood / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D051788:Myeloid-Lymphoid Leukemia Protein; D011519:Proto-Oncogenes; D014157:Transcription Factors; D014178:Translocation, Genetic; D016335:Zinc Fingers