title: Treatment of cystic ovarian disease in dairy cows with gonadotrophin-releasing hormone: a field study.
abstract: In a field trial in the Netherlands 765 dairy cows were treated during 869 lactations with 500 micrograms gonadotrophin-releasing hormone (gonadorelin i.m.) for cystic ovarian disease (COD) between June 1987 and April 1996. COD was defined as the presence of a large follicle (> 2.5 cm) on one or both of the ovaries in the absence of a corpus luteum. Two treatment groups were formed, based on the interval from parturition to first treatment, with day 60 being the cut-off between groups 1 and 2. The aim of this study is to examine whether there is a relationship between the moment of diagnosis and treatment (before or after day 60 post partum) and its result. In group 1 90.0% of first treatments were effective and in group 2 93.3% (p = 0.08). This was reflected by the slightly higher number of treatments needed for animals in group 1 (1.11 versus 1.07, p = 0.08). The efficacy rate after one treatment did not significantly differ between the groups (1.63 versus 1.69, p = 0.40) and nor did the interval between 1st insemination after treatment and conception (p < 0.63). In conclusion, it can be stated that gonadorelin is effective as therapy irrespective of the timing of diagnosis and treatment.
authors.affiliation: Wageningen Agricultural University, Wageningen Institute of Animal Science. hooijer@xs4all.nl
authors.forename: G A
authors.initials: GA
authors.lastname: Hooijer
authors.forename: K
authors.initials: K
authors.lastname: Frankena
authors.forename: M M
authors.initials: MM
authors.lastname: Valks
authors.forename: M
authors.initials: M
authors.lastname: Schuring
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005298:Fertility / Q000187:drug effects*; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000627:therapeutic use*; D010048:Ovarian Cysts / Q000188:drug therapy / Q000662:veterinary*; D006080:Ovarian Follicle / Q000187:drug effects / Q000473:pathology; D016896:Treatment Outcome