title: Exposure or absorption and the crucial question of limits for mercury.
abstract: Health Canada recently lowered the recommended maximum daily exposure of mercury from all sources for women of child-bearing age and for children less than 10 years. This new exposure guideline does not seem to be based on any new scientific finding of human toxicity. The average daily intake of methylmercury (mainly from fish) that may cause demonstrable health effects in the most sensitive individual is 300 micrograms/day, or 4.3 micrograms Hg/day/kg body weight. The new, lower Health Canada limit is 95% below the level that may cause health effects. A number of studies have looked at methylmercury in human breast milk (where maternal consumption of fish is high), but no strong evidence of toxicity has been reported. The amount of mercury released from dental amalgam is minimal; a person would have to have 490 amalgam surfaces for there to be enough mercury vapour and ionic mercury given off from amalgam fillings to meet the maximum exposure guidelines. The uptake of food-related organic mercury is six times higher than the uptake of mercury from amalgam; moreover, food-related mercury is significantly more toxic. Many studies of amalgam-related mercury are flawed by confusion between exposure and absorption for the various forms of mercury, a limited selection of data, the ignoring of confounding variables or the misclassification of data.
authors.affiliation: Dalhousie University, Halifax.
authors.forename: D W
authors.initials: DW
authors.lastname: Jones
mesh_terms: D000042:Absorption; D000328:Adult; D000368:Aged; D000818:Animals; D001711:Biotransformation; D002170:Canada; D002648:Child; D015986:Confounding Factors, Epidemiologic; D003723:Dental Amalgam / Q000737:chemistry; D004781:Environmental Exposure; D005260:Female; D005399:Fishes; D005506:Food Contamination; D017408:Guidelines as Topic; D006801:Humans; D008297:Male; D008628:Mercury / Q000009:adverse effects* / Q000032:analysis / Q000737:chemistry / Q000493:pharmacokinetics; D008630:Mercury Poisoning / Q000517:prevention & control*; D008767:Methylmercury Compounds / Q000008:administration & dosage / Q000009:adverse effects; D008875:Middle Aged; D008895:Milk, Human / Q000737:chemistry; D012307:Risk Factors