title: Ebola (subtype Reston) virus among quarantined nonhuman primates recently imported from the Philippines to the United States.
abstract: In April 1996, laboratory testing of imported nonhuman primates (as mandated by quarantine regulations) identified 2 cynomolgus macaques (Macaca fascicularis) infected with Ebola (subtype Reston) virus in a US-registered quarantine facility. The animals were part of a shipment of 100 nonhuman primates recently imported from the Philippines. Two additional infected animals, who were thought to be in the incubation phase, were identified among the remaining 48 animals in the affected quarantine room. The other 50 macaques, who had been held in a separate isolation room, remained asymptomatic, and none of these animals seroconverted during an extended quarantine period. Due to the rigorous routine safety precautions, the facility personnel had no unprotected exposures and remained asymptomatic, and no one seroconverted. The mandatory quarantine and laboratory testing requirements, put in place after the original Reston outbreak in 1989-1990, were effective for detecting and containing Ebola virus infection in newly imported nonhuman primates and minimizing potential human transmission.
authors.affiliation: Special Pathogens Branch and Molecular Pathology and Ultrastructure Activity, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. PYR3@CDC.GOV
authors.forename: P E
authors.initials: PE
authors.lastname: Rollin
authors.forename: R J
authors.initials: RJ
authors.lastname: Williams
authors.forename: D S
authors.initials: DS
authors.lastname: Bressler
authors.forename: S
authors.initials: S
authors.lastname: Pearson
authors.forename: M
authors.initials: M
authors.lastname: Cottingham
authors.forename: G
authors.initials: G
authors.lastname: Pucak
authors.forename: A
authors.initials: A
authors.lastname: Sanchez
authors.forename: S G
authors.initials: SG
authors.lastname: Trappier
authors.forename: R L
authors.initials: RL
authors.lastname: Peters
authors.forename: P W
authors.initials: PW
authors.lastname: Greer
authors.forename: S
authors.initials: S
authors.lastname: Zaki
authors.forename: T
authors.initials: T
authors.lastname: Demarcus
authors.forename: K
authors.initials: K
authors.lastname: Hendricks
authors.forename: M
authors.initials: M
authors.lastname: Kelley
authors.forename: D
authors.initials: D
authors.lastname: Simpson
authors.forename: T W
authors.initials: TW
authors.lastname: Geisbert
authors.forename: P B
authors.initials: PB
authors.lastname: Jahrling
authors.forename: C J
authors.initials: CJ
authors.lastname: Peters
authors.forename: T G
authors.initials: TG
authors.lastname: Ksiazek
mesh_terms: D000818:Animals; D000830:Animals, Laboratory / Q000821:virology*; D000914:Antibodies, Viral / Q000097:blood; D000956:Antigens, Viral / Q000097:blood; D004196:Disease Outbreaks / Q000662:veterinary; D029043:Ebolavirus / Q000145:classification / Q000276:immunology / Q000302:isolation & purification*; D019142:Hemorrhagic Fever, Ebola / Q000453:epidemiology / Q000635:transmission / Q000662:veterinary; D006801:Humans; D008252:Macaca fascicularis / Q000821:virology*; D017056:Medical Laboratory Personnel; D008992:Monkey Diseases / Q000453:epidemiology / Q000635:transmission / Q000821:virology; D010679:Philippines; D011790:Quarantine / Q000662:veterinary; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014481:United States