title: Monoacetyldiglycerides as new Ca2+ mobilizing agents in rat pancreatic acinar cells.
abstract: Several monoacetyldiglycerides were synthesized from glycerol in search for new Ca2+ mobilizing agent in vitro. All monoacetyldiglycerides except linolenoyl and phenlycyclopropylcarbonyl derivatives showed activity toward Ca2+ release in pancreatic acinar cells. Linoleoyl and docosahexaenoyl derivatives were chosen for further test and exhibited unique activity.
authors.affiliation: Department of Chemistry, Ewha Womans University, Seoul, Korea. syhan@mm.ewha.ac.kr
authors.forename: S Y
authors.initials: SY
authors.lastname: Han
authors.forename: S H
authors.initials: SH
authors.lastname: Cho
authors.forename: S Y
authors.initials: SY
authors.lastname: Kim
authors.forename: J T
authors.initials: JT
authors.lastname: Seo
authors.forename: S J
authors.initials: SJ
authors.lastname: Moon
authors.forename: G J
authors.initials: GJ
authors.lastname: Jhon
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000187:drug effects; D004075:Diglycerides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D010179:Pancreas / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D013329:Structure-Activity Relationship