title: Episodic memory and learning in patients with chronic schizophrenia.
abstract: This study explored the pattern of memory functioning in 58 patients with chronic schizophrenia and compared their performance with 53 normal controls. Multiple domains of memory were assessed, including verbal and non-verbal memory span, verbal and non-verbal paired associate learning, verbal and visual long-term memory, spatial and non-spatial conditional associative learning, recognition memory and memory for temporal order. Consistent with previous studies, substantial deficits in long-term memory were observed, with relative preservation of memory span. Memory for temporal order and recognition memory was intact, although significant deficits were observed on the conditional associative learning tasks. There was no evidence of lateralized memory impairment. In these respects, the pattern of memory impairment in schizophrenia is more similar in nature to that found in patients with memory dysfunction following mesiotemporal lobe lesions, rather than that associated with focal frontal lobe damage.
authors.affiliation: Department of Psychological Medicine, Institute of Psychiatry, London, UK.
authors.forename: T M
authors.initials: TM
authors.lastname: Rushe
authors.forename: P W
authors.initials: PW
authors.lastname: Woodruff
authors.forename: R M
authors.initials: RM
authors.lastname: Murray
authors.forename: R G
authors.initials: RG
authors.lastname: Morris
mesh_terms: D000328:Adult; D002908:Chronic Disease; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D007859:Learning Disabilities / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D008569:Memory Disorders / Q000209:etiology*; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D013702:Temporal Lobe / Q000503:physiopathology