A randomized, double-blind, placebo-controlled study of moclobemide and amitriptyline in the treatment of fibromyalgia in females without psychiatric disorder.
OBJECTIVE
To study the usefulness of moclobemide and amitriptyline in the treatment of fibromyalgia (FM) in females without psychiatric disorder.


METHODS
In the present four centre, 12 week study, 130 female FM patients not suffering from psychiatric disorders were randomized to receive amitriptyline (AMI; 25 37.5 mg), moclobemide (MOCLO; 450-600 mg) or identical placebo.


RESULTS
Seventy-four, 54 and 49 per cent of patients on AMI, MOCLO and placebo, respectively, were judged as responders. The patients on AMI also managed best regarding the respective improvements during the trial in general health, pain, sleep quality and quantity, and fatigue on visual analogue scales (VAS), the areas of the Nottingham Health Profile (NHP), as well as in the three Sheehan's functional disability scales. In the within-group comparisons, MOCLO also improved pain assessed both on VAS and on the NHP pain dimension, but the improvement was invalidated by the poor success of the drug with regard to sleep. The tolerabilities of all three drugs were comparable.


CONCLUSIONS
The study indicates that MOCLO may not be helpful in FM patients free from clinically meaningful psychiatric problems.
Hannonen
P
P
Department of Medicine, Central Hospital, Jyväskylä, Finland.
Malminiemi
K
K
Yli-Kerttula
U
U
Isomeri
R
R
Roponen
P
P
D000293:Adolescent; D000328:Adult; D000368:Aged; D000639:Amitriptyline / Q000008:administration & dosage* / Q000009:adverse effects; D000700:Analgesics / Q000008:administration & dosage* / Q000009:adverse effects; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage*; D001549:Benzamides / Q000008:administration & dosage* / Q000009:adverse effects; D004185:Disability Evaluation; D004311:Double-Blind Method; D005260:Female; D005356:Fibromyalgia / Q000188:drug therapy* / Q000523:psychology / Q000534:rehabilitation; D006801:Humans; D001523:Mental Disorders; D008875:Middle Aged; D020912:Moclobemide; D010349:Patient Compliance; D010919:Placebos; D011788:Quality of Life