Transplantation with peripheral blood stem cells, manipulated or unmanipulated, for the treatment of high-risk childhood leukemia.
Collection of peripheral blood stem cells (PBSC) does not require anesthesia or multiple marrow aspirations, and hence, is far less invasive than bone marrow collection. Most importantly, PBSC can be collected from the body's entire pool of HSC to provide more stem cells than marrow aspiration performed at localized iliac bones. This leads to the faster recovery of hematopoiesis after PBSC transplantation (PBSCT) than after bone marrow transplantation and makes 'cell component therapy' far more effective with PBSC. This review will present our pediatric experience of transplants with PBSC, purified or unmanipulated.
Takaue
Y
Y
Department of Medical Oncology, Hematopoietic Stem Cell Transplant Unit, National Cancer Center Hospital, Tokyo, Japan.
Kawano
Y
Y
Watanabe
T
T
Watanabe
A
A
D002648:Child; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D012306:Risk