title: Plexiform fibrohistiocytic tumor with a clonal cytogenetic anomaly.
abstract: Plexiform fibrohistiocytic tumors are rare lesions of proposed myofibroblastic origin occurring primarily in infants and children. There is a characteristic biphasic histology comprised of both fibroblastic and histiocyte-like components. These tumors tend to be locally aggressive with prognosis dependent on completeness of resection. A previous cytogenetic case report of this tumor described a stemline clone with a karyotype of 46,XY,-6,-8, del(4)(q25q31),del(20)(q11.2),+der(8)t(8;?) (p22;?),+mar. We report a different cytogenetic finding in another plexiform fibrohistiocytic tumor which demonstrated a simpler karyotype of 46,XY,t(4;15)(q21;q15). The implications of cytogenetic heterogeneity in fibroblastic tumors is briefly discussed.
authors.affiliation: Department of Pathology, University of New Mexico School of Medicine, Albuquerque 87131, USA.
authors.forename: G C
authors.initials: GC
authors.lastname: Redlich
authors.forename: K D
authors.initials: KD
authors.lastname: Montgomery
authors.forename: G A
authors.initials: GA
authors.lastname: Allgood
authors.forename: N E
authors.initials: NE
authors.lastname: Joste
mesh_terms: D002869:Chromosome Aberrations; D018219:Histiocytoma, Benign Fibrous / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007223:Infant; D007621:Karyotyping; D008297:Male; D019042:Muscle Neoplasms / Q000235:genetics* / Q000473:pathology