Effect of immune priming on Borna disease.
Borna disease virus (BDV) is a neurotropic virus with a broad host and geographic range. Lewis rats were immunized against BDV with a recombinant vaccinia virus expressing the BDV nucleoprotein and were later infected with BDV to evaluate protection against Borna disease (BD). Relative to animals that were not immunized, immunized animals had a decreased viral burden after challenge with infectious virus, more marked inflammation, and aggravated clinical disease. These data suggest that a more robust immune response in Borna disease can reduce viral load at the expense of increased morbidity.
Lewis
A J
AJ
Department of Neurology, University of California, Irvine, California 92697-4292, USA.
Whitton
J L
JL
Hatalski
C G
CG
Weissenböck
H
H
Lipkin
W I
WI
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D001890:Borna Disease / Q000276:immunology*; D006367:HeLa Cells; D006801:Humans; D007114:Immunization; D008297:Male; D009698:Nucleoproteins / Q000276:immunology; D012367:RNA, Viral / Q000032:analysis; D051381:Rats; D011917:Rats, Inbred Lew; D014765:Viral Vaccines / Q000276:immunology*