Ebola hemorrhagic fever, Democratic Republic of the Congo, 1995: determinants of survival.
In May 1995, an international team characterized and contained an outbreak of Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo. This study reports the descriptive features of this outbreak along with a statistical analysis of the outbreak data. Proportional hazards analysis was used to examine the effect of age, phase of the outbreak, and sex on the risk of death, and a conditional probability analysis was used to examine the effectiveness of whole blood transfusion from convalescent patients on survival. Two hundred fifty case-patients (80.7%) died. The main predictor of survival in the proportional hazards model was age. No statistical evidence of a survival benefit of transfusion of blood from convalescent patients was evident after adjusting for age, sex, and the days since onset of symptoms (P = .1713).
Sadek
R F
RF
Special Pathogens Branch, Centers for Disease Control and Prevention, USA. RFSADEK@MKG.COM
Khan
A S
AS
Stevens
G
G
Peters
C J
CJ
Ksiazek
T G
TG
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001803:Blood Transfusion; D002648:Child; D002675:Child, Preschool; D015023:Democratic Republic of the Congo / Q000453:epidemiology; D004196:Disease Outbreaks; D005260:Female; D019142:Hemorrhagic Fever, Ebola / Q000276:immunology / Q000401:mortality* / Q000628:therapy; D006801:Humans; D007116:Immunization, Passive; D007223:Infant; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012307:Risk Factors; D016019:Survival Analysis; D013997:Time Factors