[Hypertrophic cardiomyopathy during adrenocorticotrophic hormone administration in infants: a case report].
We report a 2-month-old child with infantile myoclonic seizures, who developed congestive heart failure secondary to hypertrophic cardiomyopathy while receiving adrenocorticotropic hormone (ACTH) therapy. Treatment with propranolol and withdrawal of ACTH led to the resolution of cardiac hypertrophy as determined by two-dimensional echocardiography. Possible links between ACTH therapy and the development of hypertrophic cardiomyopathy are examined. Our report confirms that a careful monitoring is required to detect cardiac abnormalities during ACTH administration.
Pala
M
M
Istituto di Clinica Medica Generale e Terapia Medica, Università degli Studi, Sassari.
Cassisa
L
L
Di Girolamo
G
G
Mameli
P
P
Malavasi
A
A
Realdi
G
G
D000324:Adrenocorticotropic Hormone / Q000009:adverse effects* / Q000627:therapeutic use; D002312:Cardiomyopathy, Hypertrophic / Q000188:drug therapy / Q000209:etiology*; D004831:Epilepsies, Myoclonic / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007223:Infant; D011433:Propranolol / Q000627:therapeutic use; D013565:Sympatholytics / Q000627:therapeutic use