Preferential injury of oligodendroblasts by a short hypoxic-ischemic insult.
One-week-old rat pups were subjected to an acute 10 min severe hypoxic-ischemic insult. Over the next 24 h, during the reperfusion period, O4 immunocytochemistry demonstrated that oligodendroblasts underwent degenerative changes that were coincident with induction of heme oxygenase. We suggest that the increased vulnerability of oligodendroblasts to oxidative stress following an hypoxic-ischemic insult may contribute to the pathogenesis of periventricular leukomalacia.
Jelinski
S E
SE
Department of Anatomy, College of Medicine, University of Saskatchewan, Saskatoon, Canada.
Yager
J Y
JY
Juurlink
B H
BH
D000818:Animals; D002545:Brain Ischemia / Q000503:physiopathology*; D002454:Cell Differentiation / Q000502:physiology; D015687:Cell Hypoxia / Q000502:physiology; D003337:Corpus Callosum / Q000166:cytology; D006360:Heat-Shock Proteins / Q000032:analysis; D006419:Heme Oxygenase (Decyclizing); D002534:Hypoxia, Brain / Q000503:physiopathology*; D016177:Macrophage-1 Antigen / Q000032:analysis; D009836:Oligodendroglia / Q000737:chemistry / Q000166:cytology* / Q000473:pathology; D018384:Oxidative Stress / Q000502:physiology; D010105:Oxygenases; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000503:physiopathology*