title: Synthetic inhibitors of DNA topoisomerase I and II.
abstract: A new type of synthetic inhibitor of DNA topoisomerase I and II was examined and several of these derivatives exhibited strong dual activity against these enzymes. This series of compounds showed high cytotoxic activities against cancer cells, but only a limited number of compounds showed any noticeable activity in an in vivo test against murine P388. Non-specific toxicity was observed in the in vivo tests.
authors.affiliation: Niigata College of Pharmacy, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Katayama
authors.forename: Y
authors.initials: Y
authors.lastname: Kawada
authors.forename: K
authors.initials: K
authors.lastname: Kaneko
authors.forename: T
authors.initials: T
authors.lastname: Oshiyama
authors.forename: N
authors.initials: N
authors.lastname: Takatsu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004278:DNA, Superhelical / Q000737:chemistry / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D007211:Indoles / Q000138:chemical synthesis / Q000494:pharmacology; D007941:Leukemia P388 / Q000188:drug therapy / Q000201:enzymology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D019906:Nuclear Magnetic Resonance, Biomolecular; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors