Pure red cell aplasia associated to clonal CD8+ T-cell large granular lymphocytosis: dependence on cyclosporin A therapy.
This case report details a single patient with pure red cell aplasia (PRCA) associated with clonal CD3+, TCRalphabeta+, TCR-Vbeta8+, CD8+, CD57+ large granular lymphocytosis whose anaemia did not respond to conventional immunosuppressive therapy but did respond to cyclosporin A (CsA). The patient has become dependent on CsA for 7 years in order to control anaemia due to associated PRCA.
Coutinho
J
J
Service of Clinical Haematology, St. Antonio's Hospital, Porto, Portugal.
Lima
M
M
dos Anjos Teixeira
M
M
Cabeda
J M
JM
Leite
F
F
Justiça
B
B
D000368:Aged; D018414:CD8-Positive T-Lymphocytes / Q000473:pathology*; D048429:Cell Size; D002999:Clone Cells; D016572:Cyclosporine / Q000627:therapeutic use; D003594:Cytoplasmic Granules; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008218:Lymphocytosis / Q000150:complications* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012010:Red-Cell Aplasia, Pure / Q000150:complications* / Q000188:drug therapy; D019966:Substance-Related Disorders / Q000097:blood