Intracranial leiomyosarcoma in a patient with AIDS.
We report an intracranial leiomyosarcoma in the pontine cistern of a 34-year-old woman infected with the human immunodeficiency virus (HIV). The clinical, radiological and pathological data are reviewed. The tumor was Epstein-Barr virus (EBV) positive by in situ hybridization. This case emphasizes that smooth muscle neoplasms arising in the setting of immunocompromise can occur intracranially, and corroborates a hypothesis that EBV coinfection may have a role in development of these tumors.
Brown
H G
HG
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.
Burger
P C
PC
Olivi
A
A
Sills
A K
AK
Barditch-Crovo
P A
PA
Lee
R R
RR
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D001932:Brain Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000473:pathology / Q000821:virology; D020031:Epstein-Barr Virus Infections / Q000150:complications; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D007890:Leiomyosarcoma / Q000150:complications* / Q000175:diagnosis / Q000473:pathology / Q000821:virology; D008279:Magnetic Resonance Imaging; D014057:Tomography, X-Ray Computed