Intraductal carcinoma (carcinoma in situ) of the pancreas with microinvasion.
We report a case of predominantly intraductal carcinoma of the pancreas with microscopic foci of invasive carcinoma in a patient with chronic pancreatitis. In this article, we discuss the pathologic and prognostic features of pancreatic carcinoma in situ. This entity is probably overlooked due to a number of reasons, including the fact that, in most cases, pancreatic ductal carcinomas are extensively infiltrative at the time of surgical removal; the atypical epithelial changes in the intraductal carcinoma had been overlooked in the presence or absence of an invasive component; epithelial changes may be missed due to insufficient sampling; and last, the differentiation with atypical epithelial hyperplasia is a subjective matter. Intraductal carcinoma of the pancreas is a distinct pathological entity with characteristic morphologic changes restricted to the ductal epithelium, bearing important prognostic implications.
Castellano-Sanchez
A A
AA
Department of Laboratory Medicine, Mount Sinai Medical Center of Greater Miami, Miami, FL 33145, USA.
Perez
M T
MT
Cabello-Inchausti
B
B
Willis
I H
IH
Pelaez
B
B
Davila
E
E
D000368:Aged; D000818:Animals; D002278:Carcinoma in Situ / Q000150:complications / Q000473:pathology*; D002760:Cholangiopancreatography, Endoscopic Retrograde; D002908:Chronic Disease; D018450:Disease Progression; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D009361:Neoplasm Invasiveness; D010183:Pancreatic Ducts / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000150:complications / Q000473:pathology*; D010195:Pancreatitis / Q000150:complications