title: Mesalazine-induced eosinophilic pneumonia.
abstract: A 35-year-old woman with a 6-month history of ulcerative colitis and treatment with oral mesalazine (5-aminosalicylic acid) developed dry cough, low-grade fever and bilaterally wandering pulmonary infiltrates. Improvement in clinical symptoms and radiological abnormalities occurred spontaneously after discontinuation of mesalazine. The transbronchial lung biopsy demonstrated the organizing stage of eosinophilic pneumonia. Drug lymphocyte stimulation test was positive for mesalazine and negative for sulfasalazine and sulfapyridine. The present case indicates that although mesalazine-induced eosinophilic pneumonia is an extremely rare entity, its possibility should be fully considered in patients developing unexplained respiratory symptoms while on mesalazine therapy.
authors.affiliation: Department of Internal Medicine, Kohseikai Hospital, Nagasaki University School of Medicine, Nagasaki, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Tanigawa
authors.forename: K
authors.initials: K
authors.lastname: Sugiyama
authors.forename: H
authors.initials: H
authors.lastname: Matsuyama
authors.forename: H
authors.initials: H
authors.lastname: Nakao
authors.forename: K
authors.initials: K
authors.lastname: Kohno
authors.forename: Y
authors.initials: Y
authors.lastname: Komuro
authors.forename: Y
authors.initials: Y
authors.lastname: Iwanaga
authors.forename: K
authors.initials: K
authors.lastname: Eguchi
authors.forename: M
authors.initials: M
authors.lastname: Kitaichi
authors.forename: H
authors.initials: H
authors.lastname: Takagi
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D003093:Colitis, Ulcerative / Q000188:drug therapy; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation; D019804:Mesalamine / Q000009:adverse effects* / Q000627:therapeutic use; D011657:Pulmonary Eosinophilia / Q000139:chemically induced* / Q000175:diagnosis