title: Synthesis and methemoglobin toxicity of the amides of 6/7 mono or disubstituted quinolone.
abstract: A series of 6/7-mono and disubstituted quinolone-3-carboxamide derivatives (1-12) were synthesized and their in vitro methemoglobin producing capacity have been delineated. The compounds 5, 6, 9 and 10 showed minimum methemoglobin toxicity.
authors.affiliation: Division of Biochemistry, Central Drug Research Institute, Lucknow, India.
authors.forename: S
authors.initials: S
authors.lastname: Srivastava
authors.forename: S K
authors.initials: SK
authors.lastname: Srivastava
authors.forename: A
authors.initials: A
authors.lastname: Shukla
authors.forename: P M
authors.initials: PM
authors.lastname: Chauhan
authors.forename: S K
authors.initials: SK
authors.lastname: Puri
authors.forename: A P
authors.initials: AP
authors.lastname: Bhaduri
authors.forename: V C
authors.initials: VC
authors.lastname: Pandey
mesh_terms: D000577:Amides / Q000737:chemistry; D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology; D042966:Cytochrome-B(5) Reductase / Q000187:drug effects / Q000378:metabolism; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D008706:Methemoglobin / Q000032:analysis / Q000187:drug effects*; D008708:Methemoglobinemia / Q000139:chemically induced; D009643:Norfloxacin / Q000494:pharmacology; D015242:Ofloxacin / Q000494:pharmacology; D015363:Quinolones / Q000138:chemical synthesis* / Q000633:toxicity*; D013329:Structure-Activity Relationship