Deletion 7q in B-cell low-grade lymphoid malignancies: a cytogenetic/fluorescence in situ hybridization and immunopathologic study.
Ten cases presenting a simple karyotype and del(7q) as a primary event were selected out of 353 patients referred as B-cell low-grade malignant lymphoproliferative disorders. Chromosome 7-specific painting probes confirmed the deletion that was tentatively assigned to bands q31q35. Chromosome 7 was involved in an interstitial deletion in seven cases, in an unbalanced translocation in two cases, and in a ring chromosome in one case. Common clinical/hematological features included advanced age, marked splenomegaly, and peripheral blood monoclonal IgM(D) lymphocytosis. Regardless of morphologic entity, most cases shared lymphoplasmacytoid features. Deletion 7q may delineate a variety of low-grade B-cell lymphoid disorders characterized by a common clinical history and immunopathologic similarities. The cytogenetic pattern and the ongoing work on molecular mapping of this deletion suggest that the loss of a putative tumor-supressor gene at 7q31q32 may constitute an early event in their pathogenesis.
Dascalescu
C M
CM
Research Group on Lymphomas, Institut Albert Bonniot, Université Joseph Fourier, Grenoble, France.
Péoc'h
M
M
Callanan
M
M
Jacob
M C
MC
Sotto
M F
MF
Gressin
R
R
Sotto
J J
JJ
Leroux
D
D
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D020223:Chromosome Painting; D002897:Chromosomes, Human, Pair 7; D003582:Cytogenetics / Q000379:methods; D005260:Female; D006801:Humans; D007072:Immunoglobulin D / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D017404:In Situ Hybridization, Fluorescence / Q000379:methods; D008207:Lymphatic Metastasis; D016393:Lymphoma, B-Cell / Q000235:genetics* / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012303:Ring Chromosomes; D013163:Splenomegaly; D014178:Translocation, Genetic