Effect of methotrexate on tubal epithelium. A report of three cases.
BACKGROUND
Tubal effects of methotrexate injections have been poorly reported.


METHODS
Three fallopian tubes were examined with light microscopy 9-13 months after tubal methotrexate injection (one case) and intramuscular methotrexate injection (two cases) given for the treatment of unruptured ectopic pregnancies. No evidence of tubal damage was found.


CONCLUSIONS
These three cases confirm previous experimental and clinical data showing the absence of a direct adverse effect of methotrexate on the fallopian tubes in the treatment of ectopic pregnancy.
Lécuru
F
F
Gynecologic and Obstetric Service, Boucicaut Hospital, Paris, France. fabrice.lecuru@bcc.ap-hop-paris.fr
Robin
F
F
Taurelle
R
R
Bernard
J P
JP
Vildé
F
F
D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000328:Adult; D004848:Epithelium / Q000187:drug effects; D005187:Fallopian Tubes / Q000187:drug effects* / Q000473:pathology; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D010535:Laparoscopy; D008727:Methotrexate / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011247:Pregnancy; D011274:Pregnancy, Tubal / Q000188:drug therapy*