title: Marchiafava-Bignami disease with widespread extracallosal lesions and favourable course.
abstract: We report a 61-year-old alcoholic man who presented with subacute physical deterioration and severe dysarthria. MRI, suggestive of corpus callosum demyelination with associated white matter involvement in both cerebral hemispheres, indicated the diagnosis of Marchiafava-Bignami disease. During his stay in hospital the patient showed remarkable improvement, and was discharged 22 days after admission. On MRI 2 months later, the extracallosal lesions had disappeared. This case raises questions about some previous ideas on this disease, such as the prognosis of its acute forms and the significance of the extracallosal lesions seen on neuroimaging.
authors.affiliation: Department of Neurology, Hospital Ntra. Sra. de Aránzazu, San Sebastián, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Ruiz-Martínez
authors.forename: A
authors.initials: A
authors.lastname: Martínez Pérez-Balsa
authors.forename: M
authors.initials: M
authors.lastname: Ruibal
authors.forename: M
authors.initials: M
authors.lastname: Urtasun
authors.forename: J
authors.initials: J
authors.lastname: Villanua
authors.forename: J F
authors.initials: JF
authors.lastname: Martí Massó
mesh_terms: D000437:Alcoholism / Q000150:complications*; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D001927:Brain Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology*; D003337:Corpus Callosum / Q000000981:diagnostic imaging / Q000473:pathology; D003711:Demyelinating Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D014057:Tomography, X-Ray Computed