Cytogenetic, ras, and p53: studies in cases of canine neoplasms (hemangiopericytoma, mastocytoma, histiocytoma, chloroma).
Four case reports of mesenchymal neoplasms showing chromosomal abnormalities are presented. In a case of hemangiopericytoma trisomy 2 and centric fusion 19;21 were present. In a mastocytoma a deleted chromosome 35 was seen. A homogeneously staining region (HSR) on chromosome 1 was detected in a histiocytoma. Trisomy 5 and monosomy 31 were observed in a case of granulocytic sarcoma (chloroma). The lack of mutations in exons 1 and 2 of oncogenes N-ras, K-ras, and H-ras and exons 5, 6, 7, and 8 of tumor suppressor gene p53 in these four patients and in a larger series of investigated dogs (25 hemangiopericytomas, 12 mastocytomas, and 8 histiocytomas) is highlighted.
Mayr
B
B
Institute for Animal Breeding and Genetics, Veterinary University, Vienna, Austria.
Reifinger
M
M
Brem
G
G
Feil
C
C
Schleger
W
W
D000818:Animals; D002869:Chromosome Aberrations / Q000662:veterinary; D025063:Chromosome Disorders; D004252:DNA Mutational Analysis / Q000662:veterinary; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D005260:Female; D006393:Hemangiopericytoma / Q000235:genetics / Q000662:veterinary*; D018219:Histiocytoma, Benign Fibrous / Q000235:genetics / Q000662:veterinary*; D007621:Karyotyping / Q000662:veterinary; D007951:Leukemia, Myeloid / Q000235:genetics / Q000662:veterinary*; D008297:Male; D012515:Mast-Cell Sarcoma / Q000235:genetics / Q000662:veterinary*; D014314:Trisomy; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*; D018631:ras Proteins / Q000235:genetics*