title: Characteristics and prognosis of KI-1 positive anaplastic large cell lymphoma in Asians.
abstract: BACKGROUND
  Ki-1 positive anaplastic large cell lymphoma is a rare type of non-Hodgkin's lymphoma (NHL), and has not been extensively described in Asian patients.
  
  
  OBJECTIVE
  To evaluate the clinical characteristics, prognostic factors and treatment outcome of Ki-1 positive lymphoma in an Asian community.
  
  
  METHODS
  A retrospective analysis of all patients with CD30 antigen positive anaplastic large cell lymphoma from 1987 to 1996 in a single institution.
  
  
  RESULTS
  Of 218 patients with NHL, ten (5%) were identified with Ki-1 positive anaplastic large cell lymphoma. Eight were Chinese, two Indians. The male:female ratio was 1.5:1, and the median age was 32 years. Seven patients presented with B-symptoms, and five had stage III/IV disease. The majority (seven of ten) was low- or low-intermediate risk according to the International Prognostic Index (IPI). Four out of five cases immunophenotyped showed a T-cell origin. Five out of eight patients who received first-line combination chemotherapy achieved a complete remission. Two relapsed, with one being re-induced into a durable second remission. One patient with recurrent cutaneous lymphoma received solely radiotherapy and was disease-free at 20+ years from diagnosis. At analysis, two patients had died, five were disease-free at four, 27, 78, 89 months and 20 years respectively, and three were alive with disease. The IPI appears to have prognostic significance.
  
  
  CONCLUSIONS
  Incidence and clinical characteristics in our Asian patients were similar to those described in Western populations. The IPI appears to have prognostic relevance. In approximately one-third of patients, long term survival can be achieved with standard treatment.
authors.affiliation: Department of Medical Oncology, National University Hospital, Singapore.
authors.forename: S C
authors.initials: SC
authors.lastname: Lee
authors.forename: Y K
authors.initials: YK
authors.lastname: Kueh
authors.forename: M
authors.initials: M
authors.lastname: Lehnert
authors.forename: S M
authors.initials: SM
authors.lastname: Chong
authors.forename: Y O
authors.initials: YO
authors.lastname: Tan
authors.forename: J
authors.initials: J
authors.lastname: Wong
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002681:China / Q000208:ethnology; D018572:Disease-Free Survival; D005006:Ethnicity / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D015994:Incidence; D007194:India / Q000208:ethnology; D017728:Lymphoma, Large-Cell, Anaplastic / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies