The use of some hydrophobic substances in tablet technology.
The objective of this work is to continue in a study of utilization of synthetic triacylglycerides of higher aliphatic acids as additives improving the flow properties of granulates and reducing die friction in the tabletting press. These effects are not supposed to interfere with the drug liberation velocity. We have evaluated the effects of the synthetic triacylglycerides in theophylline containing model tablets using magnesium stearate as the reference standard. Magnesium stearate is the lubricant of choice in the production, found in up to 80% of all industrially produced tablets.
Vitková
M
M
Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic.
Chalabala
M
M
D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D008153:Lubrication; D012995:Solubility; D013213:Starch; D013607:Tablets; D013806:Theophylline; D014280:Triglycerides / Q000737:chemistry*