Pill-induced esophagitis caused by oral rifampin.
OBJECTIVE
To report a case of pill-induced esophagitis caused by oral rifampin.


METHODS
English-language references identified via a MEDLINE search from January 1966 to May 1998 and a bibliographic review of pertinent articles.


RESULTS
A large number of oral medications have been reported to cause pill-induced esophagitis. This case represents the second report attributed to rifampin. A 70-year-old white man receiving vancomycin, gentamicin, and oral rifampin for treatment of Staphylococcus epidermidis prosthetic valve endocarditis reported dysphagia immediately after swallowing a rifampin capsule on the fourth day of therapy. The following day, fiberoptic laryngoscopy and esophagoscopy demonstrated a red capsule partially embedded in the neopharynx. A day later, upper esophageal obstruction consistent with edema related to pill-induced esophagitis was identified by barium swallow. Following the procedure, the patient was placed on total parenteral nutrition and took nothing by mouth. Sixteen days after first reporting dysphagia, he was placed on a full liquid diet. Several factors may have increased the patient's risk for pill-induced esophagitis, including age, bedridden state, gastroesophageal reflux disease, simultaneous administration of several medications, and neopharyngeal stricture.


CONCLUSIONS
Oral rifampin may cause esophagitis. Healthcare providers should be alert to the possibility of pill-induced esophagitis in susceptible patients. Patients with predisposing factors for the development of pill-induced esophagitis should be educated about proper swallowing of oral medications.
Smith
S J
SJ
School of Pharmacy, University of the Pacific, Stockton, CA, USA.
Lee
A J
AJ
Maddix
D S
DS
Chow
A W
AW
D000284:Administration, Oral; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D004697:Endocarditis, Bacterial / Q000188:drug therapy / Q000209:etiology; D004941:Esophagitis / Q000139:chemically induced*; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D016239:MEDLINE; D008297:Male; D008943:Mitral Valve; D011183:Postoperative Complications / Q000188:drug therapy; D012293:Rifampin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000209:etiology; D013212:Staphylococcus epidermidis; D013607:Tablets