Genetic linkage analysis of multicase families with fibromyalgia syndrome.
OBJECTIVE
Based on the reports of familial aggregation of fibromyalgia (FM) syndrome, we investigated its possible genetic linkage to HLA by studying multicase families.


METHODS
Forty Caucasian multicase families with a diagnosis of FM (American College of Rheumatology criteria) in 2 or more first degree relatives were investigated. Eighty-five affected and 21 unaffected members of 41 sibships were studied. Depression symptomology was assessed by Zung Self-rating Depression Scale (SDS). HLA typing was performed for A, B, and DRB 1 alleles, and haplotypes were determined with no knowledge of the subject's diagnosis. We investigated genetic linkage to the HLA region by evaluating sibships in multicase families.


RESULTS
Sibship analysis showed significant genetic linkage of FM to the HLA region (p = 0.028). Subgroup analysis was also performed for 17 families where the proband was also noted to have depression (with an SDS index value > or =60). We found that the presence of depression did not influence the observed results (p = 0.22).


CONCLUSIONS
. Our study of 40 multicase families confirms existence of a possible gene for FM that is linked with the HLA region. Our results should be regarded as preliminary and their independent confirmation by other studies is warranted.
Yunus
M B
MB
Division of Rheumatology, University of Illinois College of Medicine at Peoria, 61656, USA. Yunus@uic.edu
Khan
M A
MA
Rawlings
K K
KK
Green
J R
JR
Olson
J M
JM
Shah
S
S
D000328:Adult; D000368:Aged; D000483:Alleles; D003863:Depression / Q000235:genetics; D005190:Family; D005260:Female; D005356:Fibromyalgia / Q000235:genetics*; D005787:Gene Frequency; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D008875:Middle Aged