title: [Successful management for chemorefractory testicular cancer with brain and lung metastases. A case report].
abstract: This is a report of successful management for a far advanced, chemorefractory testicular cancer patient. A 29-year-old male was referred to our hospital for the treatment of progressive lung metastases with elevated hCG level, which had recurred after complete remission following 3 courses of BEP chemotherapy and progressed after transient partial regression following 2 courses of intensified EP chemotherapy. In addition, a 3 cm in diameter, solitary brain metastasis was detected on CT. First, we performed wedge resection of bilateral pulmonary lower lobe for chemorefractory pulmonary metastases. Histological examination revealed viable embryonal carcinoma identical to the primary one. Thereafter, whole brain irradiation in combination with VIP chemotherapy (etoposide 100 mg/m2, cisplatin 20 mg/m2 and ifosfamide 1200 mg/m2 daily for 5 consecutive days) was carried out to treat brain metastasis. By 2 cycles of VIP therapy and irradiation (36 Gy), partial tumor regression and normalization of hCG level were achieved, leading to salvage surgery of the brain metastasis which histologically proved to be necrosis. Following an additional cycle of VIP therapy, the patient has been free of recurrence 24 months after completion of the treatment.
authors.affiliation: Department of Neurosurgery, Sasa Hospital.
authors.forename: Y
authors.initials: Y
authors.lastname: Maeda
authors.forename: H
authors.initials: H
authors.lastname: Oyama
authors.forename: T
authors.initials: T
authors.lastname: Shishido
authors.forename: T
authors.initials: T
authors.lastname: Kin
authors.forename: T
authors.initials: T
authors.lastname: Izutani
authors.forename: J
authors.initials: J
authors.lastname: Yonese
authors.forename: I
authors.initials: I
authors.lastname: Fukui
authors.forename: K
authors.initials: K
authors.lastname: Nakagawa
authors.forename: S
authors.initials: S
authors.lastname: Okumura
authors.forename: H
authors.initials: H
authors.lastname: Hiratsuka
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001921:Brain / Q000601:surgery; D001932:Brain Neoplasms / Q000556:secondary*; D018236:Carcinoma, Embryonal / Q000556:secondary* / Q000628:therapy*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D019008:Drug Resistance, Neoplasm; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008175:Lung Neoplasms / Q000556:secondary*; D008297:Male; D016879:Salvage Therapy; D013736:Testicular Neoplasms / Q000473:pathology* / Q000628:therapy*