title: Relationships of cerebral MRI findings to ultrasonographic carotid atherosclerosis in older adults : the Cardiovascular Health Study. CHS Collaborative Research Group.
abstract: Cerebral magnetic resonance imaging (MRI) has demonstrated a high prevalence of infarct-like lesions, white matter hyperintensities, and evidence of cerebral atrophy in older adults. While these findings are generally believed to be related to ischemia and atherosclerosis, their relationship to atherosclerosis in the carotid arteries remains to be explored. Study subjects were part of the multicenter Cardiovascular Health Study, a cross-sectional study of 3502 women and men >/=65 years of age undergoing cranial MRI and carotid ultrasonography. MRI infarcts were detected in 1068 participants (29.3%) and measurable carotid plaque in 2745 (75.3%). MRI infarcts, ventricular and sulcal widening, and white matter score were strongly associated with carotid intimal-medial thickness (IMT) and stenosis degree after adjustment for age and sex (all P<0. 01). Associations with plaque characteristics were less strong and less consistent; MRI infarcts were weakly associated only with surface irregularity, and ventricular size was weakly associated only with lesion density (both P<0.04). In contrast, sulcal widening was strongly related to plaque characteristics, with scores being higher in those with heterogeneous and irregular plaque (both P<0. 009). Adjustment for other risk factors, and for carotid IMT/stenosis, removed associations of MRI findings with plaque characteristics except for weak relationships remaining between MRI infarcts and surface irregularity and between sulcal score and heterogeneous plaque (both P<0.03). MRI abnormalities show strong and consistent relationships with increasing carotid IMT and stenosis degree but less strong associations with plaque characteristics, especially after adjusting for IMT and stenosis.
authors.affiliation: Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD20892-7934, USA. manolio@nih.go v
authors.forename: T A
authors.initials: TA
authors.lastname: Manolio
authors.forename: G L
authors.initials: GL
authors.lastname: Burke
authors.forename: D H
authors.initials: DH
authors.lastname: O'Leary
authors.forename: G
authors.initials: G
authors.lastname: Evans
authors.forename: N
authors.initials: N
authors.lastname: Beauchamp
authors.forename: L
authors.initials: L
authors.lastname: Knepper
authors.forename: B
authors.initials: B
authors.lastname: Ward
mesh_terms: D000368:Aged; D001161:Arteriosclerosis / Q000175:diagnosis*; D001921:Brain / Q000473:pathology*; D002319:Cardiovascular System / Q000503:physiopathology; D002340:Carotid Artery Diseases / Q000150:complications / Q000175:diagnosis*; D002544:Cerebral Infarction / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D004453:Echoencephalography; D005260:Female; D006304:Health Status; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D015995:Prevalence