title: Immune regulatory loops determine productive interactions within human T lymphocyte-dendritic cell clusters.
abstract: Help for the induction of cytolytic T lymphocytes is mediated by dendritic cells (DC) that are conditioned by CD40 signaling. We identified tumor necrosis factor family member CD27L/CD70, which is expressed by cytolytic T lymphocytes on interaction with DC to control CD154 (CD40L) up-regulation on CD45RA+ helper T cells for subsequent DC stimulation. The results show that the initiation of a cytolytic immune response is determined by regulatory circuits, requiring simultaneous activation and differentiation of all cells involved in T lymphocyte-DC cluster formation.
authors.affiliation: University of Tübingen, Medical Clinic II, Otfried-Müller Strasse 10, 72076 Tübingen, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Stuhler
authors.forename: A
authors.initials: A
authors.lastname: Zobywalski
authors.forename: F
authors.initials: F
authors.lastname: Grünebach
authors.forename: P
authors.initials: P
authors.lastname: Brossart
authors.forename: V L
authors.initials: VL
authors.lastname: Reichardt
authors.forename: H
authors.initials: H
authors.lastname: Barth
authors.forename: S
authors.initials: S
authors.lastname: Stevanovic
authors.forename: W
authors.initials: W
authors.lastname: Brugger
authors.forename: L
authors.initials: L
authors.lastname: Kanz
authors.forename: S F
authors.initials: SF
authors.lastname: Schlossman
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D053282:CD27 Ligand; D019013:CD40 Antigens / Q000276:immunology*; D002478:Cells, Cultured; D003713:Dendritic Cells / Q000276:immunology*; D015789:HLA-A2 Antigen / Q000276:immunology; D006801:Humans; D018189:Immunomagnetic Separation; D017493:Leukocyte Common Antigens / Q000276:immunology; D008024:Ligands; D008565:Membrane Proteins / Q000276:immunology*; D051379:Mice; D011971:Receptors, Immunologic / Q000276:immunology; D011994:Recombinant Proteins / Q000096:biosynthesis; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014162:Transfection