[Dyslipidemias and autoimmune diseases].
The paper summarizes the results of over 30-year studies dealt with dyslipidemias and autoimmune diseases. The teaching of the antiphospholipid syndrome (APS) has aroused interest in the problem. The experience gained shows changes in the blood cholesterol transport system. Patients with systemic lupus erythematosus (SLE) have higher levels of low density lipoprotein cholesterol and lower concentrations of high density lipoprotein (HDL) cholesterol, apolipoprotein A than the controls. The quantitative and qualitative changes in particles result in decreased acceptance of cholesterol from the membrane of a cell and tissues, which promotes the development of vascular diseases. Lipoprotein (a) may be an additional risk factor for thrombosis chiefly of coronary arteries, in patients with SLE and APS. Increased levels of oxidized low density proteins having atherogenic activity were found mainly in patients with SLE. The use of corticosteroids causes the changes in the spectrum of blood lipids, which together with other factors (thrombosis, vasculopathy, thrombocytopenia, etc.) create good conditions for the development of atherosclerosis, which determines the necessity of correcting the parameters of blood lipid transport not only to prevent vascular disorders but to improve the general life prognosis in SLE patients.
Alekberova
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Nasonova
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D001327:Autoimmune Diseases / Q000097:blood / Q000150:complications* / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000209:etiology* / Q000276:immunology; D015227:Lipid Peroxidation; D008074:Lipoproteins / Q000097:blood; D011379:Prognosis; D012307:Risk Factors