Ochratoxicosis: prevention of developmental toxicity by L-methionine in rats.
L-Methionine was found to inhibit the developmental toxicity induced by ochratoxin A (OA) in pregnant female rats. The fetuses had significantly lower weights. Dams and fetuses treated with OA had visceral and skeletal anomalies, while combined treatment with L-methionine and OA showed no significant changes when compared to the control. Histopathological examinations revealed that OA caused alterations in liver, kidney and vagina of pregnant rats, whereas methionine supplementation provided partial protection for renal and liver tissue.
Abdel-Wahhab
M A
MA
Mycotoxins Laboratory, National Research Center, Dokki, Cairo, Egypt.
Nada
S A
SA
Arbid
M S
MS
D000014:Abnormalities, Drug-Induced / Q000517:prevention & control*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001842:Bone and Bones / Q000002:abnormalities; D004347:Drug Interactions; D005260:Female; D005333:Fetus / Q000187:drug effects*; D008297:Male; D008715:Methionine / Q000494:pharmacology*; D009793:Ochratoxins / Q000633:toxicity*; D011247:Pregnancy; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013723:Teratogens / Q000633:toxicity*; D014781:Viscera / Q000002:abnormalities