title: Potential effect of the administration of substance P and allergen therapy on immunoglobulin E-mediated allergic reactions in human subjects.
abstract: Previously we observed and reported that immunoglobulin E-mediated (IgE-mediated) allergy in rhesus monkeys was decreased by the administration of substance P (SP) and an allergen. We extended these studies to human subjects, giving SP and 1 allergen to subjects with reactivity to more than 1 allergen, using reactivity to a second allergen as a control. SP and an allergen were initially given by aerosol delivery but subsequently were given by injection. The administration of SP and 1 allergen by aerosol delivery or injection resulted in decreased IgE-mediated reactivity to the allergen administered and also to the control allergen. This result occurred in 7 of 8 human subjects. The 2 initial subjects receiving 8 SP and allergen injections had a sharp reduction in their symptoms of ragweed hay fever lasting for 3 years to date. No significant reactions to the injection of SP occurred. Further controlled human research is necessary on the administration of SP and allergen and the mechanisms of action. Unexpected and serendipitous results first observed in rhesus monkeys and reproduced in allergic human subjects provide a new and potential mechanism for control and perhaps obliteration of common IgE-mediated allergies and even more-serious allergic problems.
authors.affiliation: Ernest S. Bazley Asthma and Allergic Diseases Center of the Department of Medicine of Northwestern Memorial Hospital and Northwestern University Medical School, Chicago, Illinois, USA.
authors.forename: R
authors.initials: R
authors.lastname: Patterson
authors.forename: K E
authors.initials: KE
authors.lastname: Harris
authors.forename: L C
authors.initials: LC
authors.lastname: Grammer
authors.forename: P A
authors.initials: PA
authors.lastname: Greenberger
authors.forename: A M
authors.initials: AM
authors.lastname: Ditto
authors.forename: M A
authors.initials: MA
authors.lastname: Shaughnessy
mesh_terms: D000336:Aerosols; D000485:Allergens / Q000008:administration & dosage*; D001985:Bronchial Provocation Tests; D004359:Drug Therapy, Combination; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D007167:Immunotherapy; D008297:Male; D011058:Pollen; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology / Q000628:therapy*; D012882:Skin Tests; D013373:Substance P / Q000008:administration & dosage*