title: Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types.
abstract: MALT B cell lymphomas with t(1;14)(p22;q32) showed a recurrent breakpoint upstream of the promoter of a novel gene, Bcl10. Bcl10 is a cellular homolog of the equine herpesvirus-2 E10 gene: both contain an amino-terminal caspase recruitment domain (CARD) homologous to that found in several apoptotic molecules. Bcl10 and E10 activated NF-kappaB but caused apoptosis of 293 cells. Bcl10 expressed in a MALT lymphoma exhibited a frameshift mutation resulting in truncation distal to the CARD. Truncated Bcl10 activated NF-kappaB but did not induce apoptosis. Wild-type Bcl10 suppressed transformation, whereas mutant forms had lost this activity and displayed gain-of-function transforming activity. Similar mutations were detected in other tumor types, indicating that Bcl10 may be commonly involved in the pathogenesis of human malignancy.
authors.affiliation: Academic Department of Haematology and Cytogenetics, Institute of Cancer Research, Sutton, Surrey, United Kingdom.
authors.forename: T G
authors.initials: TG
authors.lastname: Willis
authors.forename: D M
authors.initials: DM
authors.lastname: Jadayel
authors.forename: M Q
authors.initials: MQ
authors.lastname: Du
authors.forename: H
authors.initials: H
authors.lastname: Peng
authors.forename: A R
authors.initials: AR
authors.lastname: Perry
authors.forename: M
authors.initials: M
authors.lastname: Abdul-Rauf
authors.forename: H
authors.initials: H
authors.lastname: Price
authors.forename: L
authors.initials: L
authors.lastname: Karran
authors.forename: O
authors.initials: O
authors.lastname: Majekodunmi
authors.forename: I
authors.initials: I
authors.lastname: Wlodarska
authors.forename: L
authors.initials: L
authors.lastname: Pan
authors.forename: T
authors.initials: T
authors.lastname: Crook
authors.forename: R
authors.initials: R
authors.lastname: Hamoudi
authors.forename: P G
authors.initials: PG
authors.lastname: Isaacson
authors.forename: M J
authors.initials: MJ
authors.lastname: Dyer
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis; D000074018:B-Cell CLL-Lymphoma 10 Protein; D001483:Base Sequence; D019556:COS Cells; D002461:Cell Line, Transformed; D002471:Cell Transformation, Neoplastic; D002878:Chromosomes, Human, Pair 1; D002883:Chromosomes, Human, Pair 14; D003001:Cloning, Molecular; D015870:Gene Expression; D006367:HeLa Cells; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D009154:Mutation; D016328:NF-kappa B / Q000378:metabolism; D009363:Neoplasm Proteins / Q000235:genetics* / Q000502:physiology; D009369:Neoplasms / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D014178:Translocation, Genetic