title: Metal release and excretion from cementless titanium alloy total knee replacements.
abstract: Concentrations of titanium, aluminum, and vanadium were measured in the serum and urine of patients with titanium alloy cementless primary total knee arthroplasty components. Patients were categorized in one of five groups. In Group 1, the patellar and tibial articulating surfaces were made of carbon fiber reinforced ultrahigh molecular weight polyethylene. In Group 2, the patellar and tibial surfaces were made of ultrahigh molecular weight polyethylene. In Group 3, the femoral titanium alloy articulating surface was nitrogen ion implanted with ultrahigh molecular weight polyethylene patellar and tibial articulating surfaces. Patients in Group 4 had failed patellar components, and Group 5 was comprised of age and gender matched control subjects without implants. Serum concentrations of titanium were approximately 50 times greater in patients with failed patellar components (Group 4) and approximately 10 times greater in patients with carbon fiber reinforced polyethylene bearing surfaces (Group 1) when compared with Groups 2 and 3 and the control subjects (Group 5). For aluminum and vanadium, no detectable differences were observed among any of the groups. In addition, analysis of 24-hour urine samples showed no significant differences in titanium, aluminum, or vanadium concentrations among any of the groups. Elevated serum titanium levels may serve as a marker of patellar component failure or accelerated femoral component wear in total knee replacements with titanium alloy bearings. The toxicologic ramifications of these findings are unknown.
authors.affiliation: Department of Orthopedic Surgery, Rush Arthritis and Orthopedics Institute, Rush Medical College, Chicago, IL 60612, USA.
authors.forename: J J
authors.initials: JJ
authors.lastname: Jacobs
authors.forename: C
authors.initials: C
authors.lastname: Silverton
authors.forename: N J
authors.initials: NJ
authors.lastname: Hallab
authors.forename: A K
authors.initials: AK
authors.lastname: Skipor
authors.forename: L
authors.initials: L
authors.lastname: Patterson
authors.forename: J
authors.initials: J
authors.lastname: Black
authors.forename: J O
authors.initials: JO
authors.lastname: Galante
mesh_terms: D000368:Aged; D000535:Aluminum / Q000378:metabolism*; D005260:Female; D006801:Humans; D007720:Knee Prosthesis; D008297:Male; D008875:Middle Aged; D011095:Polyethylenes; D011474:Prosthesis Design; D012189:Retrospective Studies; D014025:Titanium / Q000378:metabolism*; D014639:Vanadium / Q000378:metabolism*