title: Safety and efficacy of sub-antimicrobial-dose doxycycline therapy in patients with adult periodontitis.
abstract: The objectives of the studies presented here were to assess the safety and efficacy of the adjunctive administration of sub-antimicrobial-dose doxycycline (SDD) for the treatment of adult periodontitis and to confirm the optimal dosing regimen. The studies summarized included four double-blind, placebo-controlled, randomized clinical trials, conducted over a period of 9 to 12 months. Analysis of efficacy data demonstrated that adjunctive SDD treatment resulted in: (1) increases in clinical attachment levels; (2) decreases in probing pocket depths; and (3) reductions in bleeding on probing in patients with adult periodontitis. There were no significant adverse events or unwanted long-term antimicrobial effects associated with orally administered SDD. The results of these clinical trials indicate that the adjunctive use of SDD 20 mg BID is an effective and well-tolerated regimen which can significantly improve several indices of periodontal health.
authors.affiliation: Department of Periodontology, School of Dental Medicine, State University of New York at Buffalo 14214, USA.
authors.forename: S
authors.initials: S
authors.lastname: Ciancio
authors.forename: R
authors.initials: R
authors.lastname: Ashley
mesh_terms: D000328:Adult; D016301:Alveolar Bone Loss / Q000188:drug therapy / Q000473:pathology; D000704:Analysis of Variance; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D018450:Disease Progression; D004311:Double-Blind Method; D004318:Doxycycline / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D016018:Least-Squares Analysis; D017622:Periodontal Attachment Loss / Q000188:drug therapy / Q000473:pathology; D010512:Periodontal Index; D010518:Periodontitis / Q000188:drug therapy* / Q000628:therapy