Trisomy 7 and trisomy 8 in dividing and non-dividing tumor cells in Dupuytren's disease.
Cytogenetic and molecular cytogenetic analysis is reported in a series of 40 tissue samples from 36 patients with Dupuytren's disease, presenting as palmar and/or finger nodules. No consistent structural chromosome changes could be found. Instead, recurrent clonal numerical abnormalities were demonstrated in 22 of 40 tissue nodules, involving trisomies of chromosome 7 or 8 and loss of the Y chromosome. In addition, we showed that trisomy 7 and trisomy 8 were also present in non-dividing cells.
Dal Cin
P
P
Center for Human Genetics, University of Leuven, Belgium.
De Smet
L
L
Sciot
R
R
Van Damme
B
B
Van den Berghe
H
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002455:Cell Division; D002897:Chromosomes, Human, Pair 7; D002898:Chromosomes, Human, Pair 8; D004387:Dupuytren Contracture / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014314:Trisomy; D014407:Tumor Cells, Cultured