Neoplastic transformation-associated stimulation of the in vitro resolution of concatemer junction fragments from minute virus of mice DNA.
Minute virus of mice (MVM) shows an oncotropic behavior reflected by its ability to amplify its genome more efficiently in a number of transformed versus normal cells. In vivo and in vitro studies revealed that the major effect of cell transformation on MVM DNA replication occurs at the level of double-stranded replicative-form amplification. In particular, resolution of MVM DNA concatemers into monomers was found to be highly sensitive to neoplastic transformation.
Kuntz-Simon
G
G
Deutsches Krebsforschungszentrum, Department of Applied Tumor Virology, Abt. F0100 and Formation INSERM U375, Heidelberg, Germany.
Bashir
T
T
Rommelaere
J
J
Willwand
K
K
D002471:Cell Transformation, Neoplastic; D004261:DNA Replication; D004279:DNA, Viral / Q000737:chemistry*; D005784:Gene Amplification; D006801:Humans; D008915:Minute Virus of Mice / Q000235:genetics*; D014779:Virus Replication