title: Antibody and/or cell-mediated immunity, protective mechanisms in fungal disease: an ongoing dilemma or an unnecessary dispute?
abstract: Historically there has been controversy on the relative importance of antibody- and cell-mediated immune responses in the protection against fungal pathogens. The controversy was fuelled by the difficulties encountered in obtaining consistent results with polyclonal antibody experiments and I inducing long-lasting immune protection by vaccinations with induce stron cell-mediated responses. Recent studies indicate that both antibody- and cell-mediated immune responses can contribute to host protection against Candida albicans and C. neoformans. At the present time the major issue is not the relative importance of antibody- and cell-mediated immune responses but rather, the mechanisms by which the two arms of the immune system function and cooperate.
authors.affiliation: Albert Einstein College of Medicine, Bronx, New York, USA.
authors.forename: A
authors.initials: A
authors.lastname: Casadevall
authors.forename: A
authors.initials: A
authors.lastname: Cassone
authors.forename: F
authors.initials: F
authors.lastname: Bistoni
authors.forename: J E
authors.initials: JE
authors.lastname: Cutler
authors.forename: W
authors.initials: W
authors.lastname: Magliani
authors.forename: J W
authors.initials: JW
authors.lastname: Murphy
authors.forename: L
authors.initials: L
authors.lastname: Polonelli
authors.forename: L
authors.initials: L
authors.lastname: Romani
mesh_terms: D000818:Animals; D000908:Antibodies, Fungal / Q000097:blood / Q000276:immunology; D002176:Candida albicans / Q000276:immunology; D002177:Candidiasis / Q000276:immunology*; D003453:Cryptococcosis / Q000276:immunology*; D003455:Cryptococcus neoformans / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D051379:Mice