title: Multinuclear solid-state three-dimensional MRI of bone and synthetic calcium phosphates.
abstract: Multinuclear three-dimensional solid-state MRI of bone, tooth, and synthetic calcium phosphates is demonstrated in vitro and in vivo with a projection reconstruction technique based on acquisition of free induction decays in the presence of fixed amplitude magnetic field gradients. Phosphorus-31 solid-state MRI provides direct images of the calcium phosphate constituents of bone substance and is a quantitative measurement of the true volumetric bone mineral density of the bone. Proton solid-state MRI shows the density of bone matrix including its organic constituents, which consist principally of collagen. These solid-state MRI methods promise to yield a biological picture of bone richer in information concerning the bone composition and short range-crystalline order than the fluid-state images provided by conventional proton MRI or the density images produced by radiologic imaging techniques. Three-dimensional solid-state projection reconstruction MRI should be readily adaptable to both human clinical use and nonmedical applications for a variety of solids in materials science.
authors.affiliation: Biomaterials Laboratory, NMR Center, Room 2301, Department of Radiology, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Wu
authors.forename: D A
authors.initials: DA
authors.lastname: Chesler
authors.forename: M J
authors.initials: MJ
authors.lastname: Glimcher
authors.forename: L
authors.initials: L
authors.lastname: Garrido
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: H J
authors.initials: HJ
authors.lastname: Jiang
authors.forename: J L
authors.initials: JL
authors.lastname: Ackerman
mesh_terms: D001842:Bone and Bones / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry*; D006801:Humans; D006859:Hydrogen; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008963:Molar / Q000737:chemistry; D010758:Phosphorus; D012680:Sensitivity and Specificity; D014070:Tooth / Q000737:chemistry*