title: [Precocious puberty secondary to an intramedullary germinoma].
abstract: BACKGROUND
  hCG secreting tumors are responsible for 21% of precocious puberties in boys. Usual localizations are hepatic, cerebral, mediastinal and gonadic.
  
  
  METHODS
  A 4-year-old boy developed precocious puberty with rapid evolution. Serum beta hCG suggested germinal etiology, but radiological procedures failed to find any usual localization. Further occurrence of pain in the legs led to carry out a lumbar puncture. The high cerebrospinal fluid/blood gradient of beta hCG suggested the presence of an intramedullar tumor. Medullar magnetic resonance imaging found a large tumor facing L1 and L2.
  
  
  CONCLUSIONS
  To our knowledge, this localization is described for only the second time.
authors.affiliation: Service de pédiatrie multidisciplinaire, hôpital des enfants de la Timone, Marseille, France.
authors.forename: J V
authors.initials: JV
authors.lastname: de Monléon
authors.forename: G
authors.initials: G
authors.lastname: Simonin
authors.forename: O
authors.initials: O
authors.lastname: Pincemaille
authors.forename: C
authors.initials: C
authors.lastname: Buttin
authors.forename: J
authors.initials: J
authors.lastname: Sarles
mesh_terms: D002555:Cerebrospinal Fluid / Q000737:chemistry; D002675:Child, Preschool; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000032:analysis / Q000097:blood; D018237:Germinoma / Q000097:blood / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011629:Puberty, Precocious / Q000097:blood / Q000209:etiology*; D013120:Spinal Cord Neoplasms / Q000097:blood / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D013129:Spinal Puncture; D013739:Testosterone / Q000097:blood