Covariation of activity in visual and prefrontal cortex associated with subjective visual perception.
Visual areas of the occipitotemporal pathway are thought to be essential for the conscious perception of objects, but the contribution of other cortical regions and the neural mechanisms leading to the awareness of a visual stimulus remain unclear. By using functional MRI in humans exposed to bistable viewing conditions, subjective visual perception was related to covariation of activity in multiple extrastriate ventral, parietal, and prefrontal cortical areas. The coordination of activity among these regions was not linked to external sensory or motor events; rather, it reflected internal changes in perception and varied in strength with the frequency of perceptual events, suggesting that functional interactions between visual and prefrontal cortex may contribute to conscious vision. Because similar cortical systems have been implicated in short-term memory and motor planning, the results also imply that related neural processes may underlie visual awareness and the organization of voluntary behavior contingent on sensory cues.
Lumer
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Wellcome Department of Cognitive Neurology, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, United Kingdom. elumer@fil.ion.ucl.ac.uk
Rees
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D000328:Adult; D001931:Brain Mapping; D003118:Color Perception; D003463:Cues; D005133:Eye Movements; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D010296:Parietal Lobe / Q000502:physiology; D010364:Pattern Recognition, Visual; D017397:Prefrontal Cortex / Q000033:anatomy & histology / Q000502:physiology*; D014793:Visual Cortex / Q000033:anatomy & histology / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology*