title: [Interventional trial for cancer prevention].
abstract: In cancer prevention studies, the methodology of the observational study (case-control study, cohort study) and interventional study were introduced. We established a protocol for an interventional randomized controlled trial for prevention of colorectal cancer. The subjects were 200 patients with multiple colorectal tumors (adenoma and/or early cancer). Two regimens were formulated for prevention of colorectal cancer. One was dietary guidance alone (Regimen I), and the other was dietary guidance plus the eating of wheat bran biscuits (Regimen II). The main end point of the trial is recurrence of colorectal tumors after 2 and 4 years. During the 4 years, 115 patients were recruited for Regimen I and 116 patients for Regimen II who agreed to participate in this trial.
authors.affiliation: Dept. of Cancer Epidemiology, Osaka Medical Center for Cancer and Cardiovascular Diseases.
authors.forename: H
authors.initials: H
authors.lastname: Ishikawa
mesh_terms: D016022:Case-Control Studies; D018890:Chemoprevention / Q000379:methods*; D015331:Cohort Studies; D003110:Colonic Neoplasms / Q000517:prevention & control; D004032:Diet; D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000517:prevention & control*