title: Tenoxicam does not alter renal function during anaesthesia in normal individuals.
abstract: BACKGROUND
  Anaesthesia and surgery alter renal function. Inhibition of prostaglandin synthesis by non-steroidal anti-inflammatory drugs (NSAIDs) administered with anaesthesia may further compromise renal function.
  
  
  OBJECTIVE
  To study the effects of tenoxicam (NSAID) administered immediately prior to anaesthesia on renal function in normal individuals undergoing routine surgery.
  
  
  METHODS
  A randomised single blind placebo controlled study comparing tenoxicam (40 mg intravenously) with placebo was carried out in 20 healthy (ASA I) patients undergoing lower spinal surgery. Glomerular filtration rate (GFR) was determined by creatinine clearance and renal tubular function measured as osmolar and free water clearance.
  
  
  RESULTS
  GFR fell by 60% at the end of surgery but returned to pre-operative values by six hours post-operatively. There was no difference between placebo or tenoxicam with regard to changes in GFR. Tubular function was not altered by tenoxicam.
  
  
  CONCLUSIONS
  Current clinical practice of using NSAIDs for post-operative analgesia in low risk individuals appears to have no adverse effects on renal function.
authors.affiliation: Department of Anaesthesia and Intensive Care, Dunedin School of Medicine, New Zealand.
authors.forename: G M
authors.initials: GM
authors.lastname: Slaven
authors.forename: R J
authors.initials: RJ
authors.lastname: Walker
authors.forename: M
authors.initials: M
authors.lastname: Zacharias
authors.forename: J P
authors.initials: JP
authors.lastname: Fawcett
authors.forename: B F
authors.initials: BF
authors.lastname: Hodgson
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D018686:Anesthetics, Intravenous / Q000009:adverse effects*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007431:Intraoperative Complications / Q000209:etiology; D007668:Kidney / Q000187:drug effects*; D007674:Kidney Diseases / Q000139:chemically induced*; D007796:Laminectomy; D008297:Male; D010149:Postoperative Pain / Q000517:prevention & control; D010894:Piroxicam / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D011183:Postoperative Complications / Q000209:etiology; D011292:Premedication; D016037:Single-Blind Method; D014563:Urodynamics / Q000187:drug effects