title: [The use of ketamine in an experimental model of generalized cerebral ischemia].
abstract: Thus far, a sufficiently effective cerebroprotective substances has not been discovered. Glutamate overproduction plays a key role in ischemic brain lesion. Ketamine is assigned to the group of commonly used clinical anesthetics, being also familiar as NMDA antagonist. Sodium fluoride-induced cerebral ischemia in mice is used as a model of circulatory ischemic lesion. As shown by the experimental data, simultaneous administration of NaF + ketamine has no effect whatsoever on the survivorship of animals, as compared to that in the control group treated with NaF alone. Beforehand treatment of mice with 150 mg/kg ketamine brings about considerable prolongation of the survival term (15 per cent of the animals survive for more than 2 hours). The inference is reached that ketamine is endowed with cerebroprotective activity largely attributable to glutamate antagonism at the level of ischemia involved neurons.
authors.forename: D
authors.initials: D
authors.lastname: Vasilev
authors.forename: S
authors.initials: S
authors.lastname: Konstantinov
authors.forename: Zh
authors.initials: Zh
authors.lastname: Konstantinova
authors.forename: Ia
authors.initials: Ia
authors.lastname: Nachkov
authors.forename: M
authors.initials: M
authors.lastname: Karaivanova
authors.forename: P
authors.initials: P
authors.lastname: Stamenova
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000139:chemically induced / Q000188:drug therapy* / Q000401:mortality; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D018691:Excitatory Amino Acid Antagonists / Q000627:therapeutic use*; D005260:Female; D007649:Ketamine / Q000627:therapeutic use*; D051379:Mice; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D012969:Sodium Fluoride; D018709:Statistics, Nonparametric; D013997:Time Factors