title: Trisomy 7 and trisomy 8 in dividing and non-dividing tumor cells in Dupuytren's disease.
abstract: Cytogenetic and molecular cytogenetic analysis is reported in a series of 40 tissue samples from 36 patients with Dupuytren's disease, presenting as palmar and/or finger nodules. No consistent structural chromosome changes could be found. Instead, recurrent clonal numerical abnormalities were demonstrated in 22 of 40 tissue nodules, involving trisomies of chromosome 7 or 8 and loss of the Y chromosome. In addition, we showed that trisomy 7 and trisomy 8 were also present in non-dividing cells.
authors.affiliation: Center for Human Genetics, University of Leuven, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Dal Cin
authors.forename: L
authors.initials: L
authors.lastname: De Smet
authors.forename: R
authors.initials: R
authors.lastname: Sciot
authors.forename: B
authors.initials: B
authors.lastname: Van Damme
authors.forename: H
authors.initials: H
authors.lastname: Van den Berghe
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002455:Cell Division; D002897:Chromosomes, Human, Pair 7; D002898:Chromosomes, Human, Pair 8; D004387:Dupuytren Contracture / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014314:Trisomy; D014407:Tumor Cells, Cultured