title: Pure red cell aplasia associated to clonal CD8+ T-cell large granular lymphocytosis: dependence on cyclosporin A therapy.
abstract: This case report details a single patient with pure red cell aplasia (PRCA) associated with clonal CD3+, TCRalphabeta+, TCR-Vbeta8+, CD8+, CD57+ large granular lymphocytosis whose anaemia did not respond to conventional immunosuppressive therapy but did respond to cyclosporin A (CsA). The patient has become dependent on CsA for 7 years in order to control anaemia due to associated PRCA.
authors.affiliation: Service of Clinical Haematology, St. Antonio's Hospital, Porto, Portugal.
authors.forename: J
authors.initials: J
authors.lastname: Coutinho
authors.forename: M
authors.initials: M
authors.lastname: Lima
authors.forename: M
authors.initials: M
authors.lastname: dos Anjos Teixeira
authors.forename: J M
authors.initials: JM
authors.lastname: Cabeda
authors.forename: F
authors.initials: F
authors.lastname: Leite
authors.forename: B
authors.initials: B
authors.lastname: Justiça
mesh_terms: D000368:Aged; D018414:CD8-Positive T-Lymphocytes / Q000473:pathology*; D048429:Cell Size; D002999:Clone Cells; D016572:Cyclosporine / Q000627:therapeutic use; D003594:Cytoplasmic Granules; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008218:Lymphocytosis / Q000150:complications* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012010:Red-Cell Aplasia, Pure / Q000150:complications* / Q000188:drug therapy; D019966:Substance-Related Disorders / Q000097:blood