Ultrastructural changes in rat hepatocytes in acute intoxication with 2,4-dichlorophenoxyacetic acid (2,4-D).
The hepatotoxic effect of 2,4-dichlorophenoxyacetic acid (2,4-D) was investigated. Ultrastructural changes were evaluated in transmission electron microscope. The experiment used 60 male Wistar rats divided into two groups: I--control-18 animals and II--42 animals which received chemically pure 2,4-D acid by gastric gavage in a dose of 200 mg/kg b.w. The animals were sacrificed after 12, 24, 48 hours and 4, 10 and 30 days of the experiment. The results obtained indicate that the administration of 2,4-D acid to rats in a dose inducing acute intoxication leads to ultrastructural changes in the liver, which suggest nonspecific reversible adaptative-type damage to parenchymal cells. The changes observed indicate disorders in energetic processes in hepatocytes and are morphological exponents of detoxicative processes there.
Sulik
M
M
Department of Pathological Anatomy, Medical Academy of Białystok.
Kisielewski
W
W
Szynaka
B
B
Kemona
A
A
Sulkowska
M
M
Sulik
A
A
Baltaziak
M
M
D015084:2,4-Dichlorophenoxyacetic Acid / Q000633:toxicity*; D000208:Acute Disease; D000818:Animals; D002470:Cell Survival; D002478:Cells, Cultured; D004195:Disease Models, Animal; D006540:Herbicides / Q000633:toxicity*; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000648:ultrastructure*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values