The benefits and risks of n-3 polyunsaturated fatty acids.
There is a growing number of animal models and clinical trials of n-3 polyunsaturated fatty acid (PUFAs) supplementation in disease. Epidemiologic and biochemical studies have suggested beneficial effects of n-3 PUFAs. But also, the use of n-3 PUFAs has some potential toxicological risks that can be circumvented by careless processing, storing, and preserving the PUFAs. The use of n-3 PUFAs is safe if appropriate preparations and dosages are selected. Much research is needed to clarify their use under different disease conditions. The newly established clinical and nutritional facts on n-3 PUFAs will induce industry to develop food products based on this knowledge.
Takahata
K
K
Faculty of Agriculture, Okayama University, Japan. baiyou-1@cc.okayama-u.ac.jp
Monobe
K
K
Tada
M
M
Weber
P C
PC
D002318:Cardiovascular Diseases / Q000517:prevention & control; D002986:Clinical Trials as Topic; D019587:Dietary Supplements; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use*; D005544:Forecasting; D006306:Health Surveys; D006801:Humans; D012016:Reference Values; D018570:Risk Assessment