title: Dermorphin and deltorphin glycosylated analogues: synthesis and antinociceptive activity after systemic administration.
abstract: In the present paper we describe the synthesis of some dermorphin and deltorphin analogues beta-O- and alpha-C-glycosylated on the C-terminal amino acid residue and report their opioid receptor affinity and selectivity as well as their analgesic potency after subcutaneous injection in mice.
authors.affiliation: Institute of Medical Pharmacology, University "La Sapienza" of Rome, P.le Aldo Moro, 5, I-00185 Rome, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Negri
authors.forename: R
authors.initials: R
authors.lastname: Lattanzi
authors.forename: F
authors.initials: F
authors.lastname: Tabacco
authors.forename: L
authors.initials: L
authors.lastname: Orrù
authors.forename: C
authors.initials: C
authors.lastname: Severini
authors.forename: B
authors.initials: B
authors.lastname: Scolaro
authors.forename: R
authors.initials: R
authors.lastname: Rocchi
mesh_terms: D000595:Amino Acid Sequence; D000701:Analgesics, Opioid / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D006031:Glycosylation; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D009130:Muscle, Smooth / Q000187:drug effects; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018847:Opioid Peptides; D011957:Receptors, Opioid / Q000187:drug effects