title: Synthesis and evaluation of potent and selective c-GMP phosphodiesterase inhibitors.
abstract: Syntheses and structure-activity relationships (SAR) of cGMP selective phosphodiesterase inhibitors are discussed. Potent and selective inhibitors are produced when the C-2 position of tetracyclic guanine 1 is substituted with alkyl chains containing six carbon atoms.
authors.affiliation: Schering-Plough Research Institute, Kenilworth, NJ 07033, USA.
authors.forename: G D
authors.initials: GD
authors.lastname: Ho
authors.forename: L
authors.initials: L
authors.lastname: Silverman
authors.forename: A
authors.initials: A
authors.lastname: Bercovici
authors.forename: C
authors.initials: C
authors.lastname: Puchalski
authors.forename: D
authors.initials: D
authors.lastname: Tulshian
authors.forename: Y
authors.initials: Y
authors.lastname: Xia
authors.forename: M
authors.initials: M
authors.lastname: Czarniecki
authors.forename: M
authors.initials: M
authors.lastname: Green
authors.forename: R
authors.initials: R
authors.lastname: Cleven
authors.forename: H
authors.initials: H
authors.lastname: Zhang
authors.forename: A
authors.initials: A
authors.lastname: Fawzi
mesh_terms: D015106:3',5'-Cyclic-GMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D004353:Drug Evaluation, Preclinical; D006147:Guanine / Q000737:chemistry; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D007527:Isoenzymes; D010726:Phosphodiesterase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D011687:Purines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship