title: Sperm creatine kinase activity in normospermic and oligozospermic Hungarian men.
abstract: OBJECTIVE
  Our purpose was to measure sperm creatine phosphokinase (CK) activity, which reflects cytoplasmic retention in immature spermatozoa, in normospermic and oligozospermic Hungarian men.
  
  
  METHODS
  A study of 109 randomly selected men in a university-based andrology laboratory was done.
  
  
  RESULTS
  CK activity differed between normospermic and oligozospermic men (0.21 +/- 0.02 vs. 1.19 +/- 0.15 CK IU/10(8) sperm; n = 56 and n = 53; mean +/- standard error of the mean, respectively). There was an inverse correlation between sperm concentration and CK activity (r = -0.70; n = 109). However, 28% of men in the range with less than 10 million sperm/ml had normal sperm CK activity (below the mean + 2 standard deviations of the group with greater than 30 x 10(6) sperm/ml), whereas 36% of men in the group with 20-30 million sperm/ml and 5% in the group with greater than 30 million sperm/ml had elevated CK activities, indicating that the incidence of mature and immature spermatozoa in specimens is independent from the sperm concentrations.
  
  
  CONCLUSIONS
  The improved facility of sperm CK activity measurements, compared with sperm concentrations, in the assessment of sperm maturity was confirmed in a Hungarian population. The CK measurements aid the selection of the most efficient treatment for couples with male-factor or unexplained infertility, particularly when considering the options of intrauterine insemination, varicocelectomy followed by a waiting period, or ovulation workup/induction in wives of men who are oligozospermic but may have fertile sperm.
authors.affiliation: Department of Obstetrics and Gynecology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
authors.forename: A
authors.initials: A
authors.lastname: Gergely
authors.forename: J
authors.initials: J
authors.lastname: Szöllösi
authors.forename: G
authors.initials: G
authors.lastname: Falkai
authors.forename: B
authors.initials: B
authors.lastname: Resch
authors.forename: L
authors.initials: L
authors.lastname: Kovacs
authors.forename: G
authors.initials: G
authors.lastname: Huszar
mesh_terms: D015415:Biomarkers; D003402:Creatine Kinase / Q000378:metabolism*; D006801:Humans; D006814:Hungary; D008297:Male; D009845:Oligospermia / Q000201:enzymology*; D012661:Semen / Q000166:cytology; D013076:Sperm Count; D013094:Spermatozoa / Q000201:enzymology*