title: Thrombotic thrombocytopenic purpura complicating chronic myelogenous leukemia treated with interferon-alpha. A report of two successfully treated patients.
abstract: Two patients with chronic myelogenous leukemia are described in whom thrombotic thrombocytopenic purpura (TTP) developed following treatment by interferon-alpha. In one of the patients, a lymphoblastic transformation was diagnosed concomitantly. Prompt institution of plasmapheresis, steroids and vincristine resulted in complete resolution. In the hitherto reported case of TTP complicating interferon-alpha treated chronic myelogenous leukemia, the course was fatal.
authors.affiliation: Department of Medicine D, Meir Hospital, Kfar-Saba, Israel. ritam@netvision.net.il
authors.forename: R
authors.initials: R
authors.lastname: Rachmani
authors.forename: A
authors.initials: A
authors.lastname: Avigdor
authors.forename: M
authors.initials: M
authors.lastname: Youkla
authors.forename: P
authors.initials: P
authors.lastname: Raanani
authors.forename: M
authors.initials: M
authors.lastname: Zilber
authors.forename: M
authors.initials: M
authors.lastname: Ravid
authors.forename: I
authors.initials: I
authors.lastname: Ben-Bassat
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects* / Q000627:therapeutic use; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000188:drug therapy*; D008875:Middle Aged; D011697:Purpura, Thrombotic Thrombocytopenic / Q000209:etiology* / Q000628:therapy; D016896:Treatment Outcome