title: ThinPrep Pap Test. Accuracy for glandular disease.
abstract: OBJECTIVE
  Although the ThinPrep Pap Test is replacing conventional Pap smears in many clinical practices, experience with the identification of glandular lesions is limited. In this study, ThinPrep cytology of glandular lesions was evaluated in a large, inner city teaching hospital with high rates of glandular abnormality.
  
  
  METHODS
  Six months of ThinPrep diagnoses in 1998, following nearly 100% conversion of the laboratory to the ThinPrep Pap Test, were compared to January-December 1997 conventional smear diagnoses for glandular disease. Biopsy confirmation was evaluated for these cases. Findings on all biopsy-confirmed glandular cases were also compared to findings on cytology.
  
  
  RESULTS
  Similar overall rates of glandular cytology were found. For conventional smears (12 months), 46 cases were diagnosed out of 43,289 smears (0.11%). For ThinPrep cytology (six months), 36 cases were diagnosed out of 25,783 slides (0.14%, P = NS). In the year 1997, 9 biopsy-confirmed conventional smear diagnoses of adenocarcinoma in situ (AIS) or adenocarcinoma were noted versus 10 for six months of 1998 for the ThinPrep method. A statistically significant reduction in the number of miscellaneous nonglandular (squamous) biopsy diagnoses were found with ThinPrep glandular cytology (14 vs. 4 cases, P < .05). For known biopsy-confirmed glandular cases of AIS or adenocarcinoma, a statistically significant reduction in the cytology false negative rate was noted with the ThinPrep method (17 vs. 4 cases, P < .02).
  
  
  CONCLUSIONS
  The ThinPrep method provides more accurate diagnoses of glandular disease, with an increase in both sensitivity and specificity for glandular lesions.
authors.affiliation: Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235-9073, USA.
authors.forename: R
authors.initials: R
authors.lastname: Ashfaq
authors.forename: D
authors.initials: D
authors.lastname: Gibbons
authors.forename: C
authors.initials: C
authors.lastname: Vela
authors.forename: M H
authors.initials: MH
authors.lastname: Saboorian
authors.forename: F
authors.initials: F
authors.lastname: Iliya
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000473:pathology*; D001706:Biopsy; D002278:Carcinoma in Situ / Q000175:diagnosis / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000473:pathology; D005260:Female; D006786:Hospitals, Urban / Q000592:standards; D006801:Humans; D007755:Laboratories, Hospital / Q000592:standards; D008403:Mass Screening / Q000379:methods / Q000592:standards; D065006:Papanicolaou Test; D010338:Pathology, Clinical / Q000379:methods / Q000592:standards; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000473:pathology*; D014626:Vaginal Smears / Q000379:methods* / Q000592:standards*