[The use of ketamine in an experimental model of generalized cerebral ischemia].
Thus far, a sufficiently effective cerebroprotective substances has not been discovered. Glutamate overproduction plays a key role in ischemic brain lesion. Ketamine is assigned to the group of commonly used clinical anesthetics, being also familiar as NMDA antagonist. Sodium fluoride-induced cerebral ischemia in mice is used as a model of circulatory ischemic lesion. As shown by the experimental data, simultaneous administration of NaF + ketamine has no effect whatsoever on the survivorship of animals, as compared to that in the control group treated with NaF alone. Beforehand treatment of mice with 150 mg/kg ketamine brings about considerable prolongation of the survival term (15 per cent of the animals survive for more than 2 hours). The inference is reached that ketamine is endowed with cerebroprotective activity largely attributable to glutamate antagonism at the level of ischemia involved neurons.
Vasilev
D
D
Konstantinov
S
S
Konstantinova
Zh
Zh
Nachkov
Ia
Ia
Karaivanova
M
M
Stamenova
P
P
D000818:Animals; D002545:Brain Ischemia / Q000139:chemically induced / Q000188:drug therapy* / Q000401:mortality; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D018691:Excitatory Amino Acid Antagonists / Q000627:therapeutic use*; D005260:Female; D007649:Ketamine / Q000627:therapeutic use*; D051379:Mice; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D012969:Sodium Fluoride; D018709:Statistics, Nonparametric; D013997:Time Factors