Endometrial cancer in polyps associated with tamoxifen use.
We report 5 cases of carcinoma arising within tamoxifen-associated endometrial polyps. In 4 of 5 cases there were no other changes within the endometrium. Given these findings, the sonohysterographic differentiation between a polypoid structure and thickened endometrium does not eliminate the need for histologic sampling of the uterine cavity.
Ramondetta
L M
LM
Department of Obstetrics and Gynecology and the Department of Pathology, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Sherwood
J B
JB
Dunton
C J
CJ
Palazzo
J P
JP
D000368:Aged; D001706:Biopsy; D016889:Endometrial Neoplasms / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D004965:Estrogen Antagonists / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D011127:Polyps / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D013629:Tamoxifen / Q000009:adverse effects*; D014592:Uterine Hemorrhage