title: Chemical stability of adapalene and tretinoin when combined with benzoyl peroxide in presence and in absence of visible light and ultraviolet radiation.
abstract: Adapalene and tretinoin are molecules used in the topical treatment of acne vulgaris. Commercial formulations (adapalene 0.1% gel and tretinoin 0.025% gel) were mixed with equal volumes of commercially available benzoyl peroxide formulation (10% lotion) and subsequently exposed to light over 24 h. With and without exposition to light, adapalene exhibits a remarkable stability whereas tretinoin is very sensitive to light and oxidation. The combination of benzoyl peroxide and light results in more than 50% degradation of tretinoin in about 2 h and 95% in 24 h.
authors.affiliation: Galderma R & D, Valbonne, France.
authors.forename: B
authors.initials: B
authors.lastname: Martin
authors.forename: C
authors.initials: C
authors.lastname: Meunier
authors.forename: D
authors.initials: D
authors.lastname: Montels
authors.forename: O
authors.initials: O
authors.lastname: Watts
mesh_terms: D000068816:Adapalene; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000528:radiation effects*; D001585:Benzoyl Peroxide / Q000737:chemistry / Q000528:radiation effects*; D002851:Chromatography, High Pressure Liquid; D004338:Drug Combinations; D004355:Drug Stability; D005782:Gels; D007641:Keratolytic Agents / Q000737:chemistry / Q000528:radiation effects*; D008027:Light; D009281:Naphthalenes / Q000737:chemistry / Q000528:radiation effects*; D014212:Tretinoin / Q000737:chemistry / Q000528:radiation effects*; D014466:Ultraviolet Rays