Effects of red blood cells on the coagulation of blood in normal and preeclamptic pregnancies.
OBJECTIVE
The objective of this study was to determine the cellular effects of whole blood, especially of red blood cells, on the hypercoagulability of blood from patients with preeclampsia.


METHODS
The time elapsed between mixing and the onset of coagulation was measured by means of a highly sensitive rheometer for whole blood, platelet-rich plasma (in which red blood cells had been removed from whole blood), and platelet-free plasma from 3 groups of subjects: 25 nonpregnant women, 25 women with normal pregnancies, and 10 patients with preeclampsia.


RESULTS
Time to coagulation for whole blood from patients with preeclampsia was significantly shorter than that for whole blood from women with normal pregnancies. However, there was no significant difference in time to coagulation for platelet-rich plasma between women with preeclampsia and those with normal pregnancies.


CONCLUSIONS
Hypercoagulability of blood in preeclampsia appears to be strongly related to red blood cell alterations.
Kaibara
M
M
Department of Obstetrics and Gynecology, Teikyo University School of Medicine, Japan.
Mitsuhashi
Y
Y
Watanabe
T
T
Tamiaki
F
F
Nishihira
M
M
Sadatsuki
M
M
Aisaka
K
K
D000328:Adult; D001777:Blood Coagulation; D001792:Blood Platelets / Q000502:physiology; D004912:Erythrocytes / Q000502:physiology*; D005260:Female; D006801:Humans; D010949:Plasma / Q000502:physiology; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D013997:Time Factors