title: [Spread of spinal anesthesia with 3 different hyperbaric solutions used in Japan].
abstract: We studied the spread of spinal anesthesia with 3 different hyperbaric solutions commercially available in Japan. Percamin-S [0.3% dibucaine in 5% hyperbaric saline] (P), Neo-Percamin.S [0.24% dibucaine with 0.12% T-caine in 9.5% glucose] (N) and 0.5% Tetcaine [tetracaine] in 10% glucose (T) were studied. Two ml of each solution was administered intrathecally using a 25 gauge Quincke needle. Patients (n = 90) were allocated to one of 9 groups receiving 2 ml of P, N or T at L 2-3, L 3-4 or L 4-5 interspace. Both N and T produced significantly higher spread of analgesia than P at any of L 3-4 and L 4-5 interspaces. P and N have the same specific gravity, even though significant differences were found in spread of segmental analgesia. Local anesthesic agents and solvent solutions themselves are considered to influence the spread of spinal anesthesia as the specific gravity of hyperbaric solution does.
authors.affiliation: Department of Anesthesiology, Chiba-Hokusoh Hospital, Nippon Medical School.
authors.forename: R
authors.initials: R
authors.lastname: Masuda
authors.forename: K
authors.initials: K
authors.lastname: Yokoyama
authors.forename: T
authors.initials: T
authors.lastname: Inoue
mesh_terms: D000328:Adult; D000368:Aged; D000775:Anesthesia, Spinal; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000493:pharmacokinetics*; D003992:Dibucaine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D005947:Glucose; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D008875:Middle Aged; D012965:Sodium Chloride; D012996:Solutions; D013046:Specific Gravity; D013748:Tetracaine / Q000008:administration & dosage / Q000493:pharmacokinetics*