title: The "spotted" locus maps to bovine chromosome 6 in a Hereford-Cross population.
abstract: The spotted locus is responsible for several phenotypically distinguishable piebald patterns in cattle, including Hereford, or white face (SH), lineback (SP), and recessive spotting (s), in addition to nonspotted (S+). In a backcross mapping population, the S locus has been mapped by genetic linkage to bovine chromosome 6, between microsatellite markers BM4528 and EL03. This region corresponds comparatively to a region on mouse chromosome 5 which houses several coat color mutations, among which homology is possible with Hardy-Zuckerman 4 feline sarcoma viral oncogene homologue (Kit), patch (Ph), and rump white (Rw). Mutations at these loci resemble mutations at the bovine S locus in both phenotype and mode of inheritance. Data are presented which show genetic linkage between the bovine S locus and microsatellite markers on chromosome 6. Candidate genes for the bovine S locus are discussed.
authors.affiliation: USDA-ARS, Fort Keogh Livestock and Range Research Laboratory, Miles City, MT 59301, USA.
authors.forename: M D
authors.initials: MD
authors.lastname: Grosz
authors.forename: M D
authors.initials: MD
authors.lastname: MacNeil
mesh_terms: D000818:Animals; D002417:Cattle / Q000235:genetics*; D002874:Chromosome Mapping / Q000662:veterinary*; D002875:Chromosomes; D003433:Crosses, Genetic; D005260:Female; D008040:Genetic Linkage; D006200:Hair Color / Q000235:genetics*; D008297:Male; D051379:Mice; D018895:Microsatellite Repeats; D010641:Phenotype; D019655:Quantitative Trait, Heritable; D012689:Sequence Homology, Nucleic Acid; D012880:Skin Pigmentation / Q000235:genetics*