title: Toxicity and osmoprotective activities of analogues of glycine betaine obtained by solid phase organic synthesis towards Sinorhizobium meliloti.
abstract: Seven analogues of the bacterial osmoprotectant glycine betaine (GB, trimethylammonioacetate), in which the methyl groups of the Me3N+ moiety are replaced by various substituents, were obtained by SPOS using Wang resin. Their biological activities (osmoprotection vs toxicity), appeared closely related to their uptake efficiency and their catabolism in the betaine-demethylating model bacterium Sinorhizobium meliloti.
authors.affiliation: Université de Rennes 1, Groupe Membranes et Osmorégulation, UPRES-A CNRS 6026, Rennes-France.
authors.forename: A
authors.initials: A
authors.lastname: Cosquer
authors.forename: V
authors.initials: V
authors.lastname: Pichereau
authors.forename: D
authors.initials: D
authors.lastname: Le Mée
authors.forename: M
authors.initials: M
authors.lastname: Le Roch
authors.forename: J
authors.initials: J
authors.lastname: Renault
authors.forename: B
authors.initials: B
authors.lastname: Carboni
authors.forename: P
authors.initials: P
authors.lastname: Uriac
authors.forename: T
authors.initials: T
authors.lastname: Bernard
mesh_terms: D001622:Betaine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D002455:Cell Division; D002625:Chemistry, Organic / Q000379:methods*; D004926:Escherichia coli / Q000187:drug effects / Q000502:physiology; D009997:Osmotic Pressure / Q000187:drug effects*; D016962:Sinorhizobium meliloti / Q000187:drug effects* / Q000502:physiology; D004113:Succimer / Q000493:pharmacokinetics / Q000494:pharmacology