title: Coxsackievirus and adenovirus receptor cytoplasmic and transmembrane domains are not essential for coxsackievirus and adenovirus infection.
abstract: Coxsackievirus and adenovirus receptor (CAR) from which the cytoplasmic domain had been deleted and glycosylphosphatidylinositol (GPI)-anchored CAR lacking both transmembrane and cytoplasmic domains were both capable of facilitating adenovirus 5-mediated gene delivery and infection by coxsackievirus B3. These results indicate that the CAR extracellular domain is sufficient to permit virus attachment and entry and that the presence of a GPI anchor does not prevent infection.
authors.affiliation: Division of Immunologic and Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.forename: J M
authors.initials: JM
authors.lastname: Bergelson
mesh_terms: D000256:Adenoviridae / Q000502:physiology*; D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D003593:Cytoplasm / Q000737:chemistry; D004770:Enterovirus / Q000502:physiology*; D017261:Glycosylphosphatidylinositols / Q000502:physiology; D011991:Receptors, Virus / Q000502:physiology*; D014162:Transfection