title: Direct-to-vial use of the AutoCyte PREP liquid-based preparation for cervical-vaginal specimens in three European laboratories.
abstract: OBJECTIVE
  To compare the AutoCyte PREP direct-to-vial procedure to the conventional Pap smear in two large and similar patient groups compiled from the testing experience of three cytology laboratories in Switzerland and France.
  
  
  METHODS
  Randomly selected, large patient groups were evaluated using either the conventional Pap smear or the AutoCyte PREP direct-to-vial liquid-based preparation. Results were then compared statistically as to disease detection and sample adequacy.
  
  
  RESULTS
  Specimen adequacy was greatly improved in the group tested with the AutoCyte PREP. PREP also demonstrated a significant reduction in ASCUS and ASCUS:LSIL+ ratios. The three laboratories participating in this review found significantly improved detection of both low and high grade SIL. Routine use of AutoCyte PREP for cervical cytology screening offers substantial improvements in adequacy and disease detection.
authors.affiliation: Center for Cytology and Clinical Pathology, University Hospital, Geneva, Switzerland. vassilakos@cytopath.int.ch
authors.forename: P
authors.initials: P
authors.lastname: Vassilakos
authors.forename: J
authors.initials: J
authors.lastname: Saurel
authors.forename: R
authors.initials: R
authors.lastname: Rondez
mesh_terms: D003584:Cytological Techniques; D005060:Europe; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation / Q000379:methods / Q000592:standards; D007755:Laboratories, Hospital / Q000592:standards*; D008403:Mass Screening / Q000295:instrumentation / Q000379:methods / Q000592:standards; D065006:Papanicolaou Test; D010338:Pathology, Clinical / Q000295:instrumentation / Q000379:methods* / Q000592:standards*; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000473:pathology; D014626:Vaginal Smears / Q000295:instrumentation / Q000379:methods* / Q000592:standards*