title: Platelet glycoprotein IIb/IIIa receptor antagonists derived from isoxazolidines.
abstract: A series of isoxazolidines has been synthesized as mimetics of the RGD sequence and was evaluated as antagonists of the platelet glycoprotein IIb/IIIa receptor. These compounds were shown to be highly potent GPIIb/IIIa antagonists, exhibiting submicromolar potencies.
authors.affiliation: DuPont Pharmaceuticals Company, DuPont Experimental Station, Wilmington, DE 19880-0336, USA.
authors.forename: P N
authors.initials: PN
authors.lastname: Confalone
authors.forename: F
authors.initials: F
authors.lastname: Jin
authors.forename: S A
authors.initials: SA
authors.lastname: Mousa
mesh_terms: D000818:Animals; D004285:Dogs; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D006801:Humans; D007555:Isoxazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*