title: Suppressed apoptotic susceptibility in human endometrial epithelial cells pretreated with hepatocyte growth factor.
abstract: Hepatocyte growth factor (HGF) and its receptor are strongly expressed perimenstrually in human endometrial epithelium, but their functions remain unknown. In this study the effects of HGF on Fas-mediated apoptosis in the human endometrial epithelial cell line HHUA were investigated. It was found that HGF inhibited Fas-mediated growth suppression and DNA fragmentation in the cells without any increase in Fas antigen expression on the cells. This results suggests that HGF inhibits Fas-mediated apoptotic signals in the endometrium, and possibly plays a role in reshaping the endometrium during menstruation.
authors.affiliation: Department of Obstyetrics & Gynecology, Osaka City University Medical School, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
authors.forename: K
authors.initials: K
authors.lastname: Mizuno
authors.forename: N
authors.initials: N
authors.lastname: Umesaki
authors.forename: S
authors.initials: S
authors.lastname: Ogita
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D017209:Apoptosis; D002455:Cell Division / Q000187:drug effects; D053938:DNA Fragmentation; D004305:Dose-Response Relationship, Drug; D016889:Endometrial Neoplasms / Q000473:pathology*; D004717:Endometrium / Q000166:cytology* / Q000187:drug effects; D004848:Epithelium / Q000473:pathology; D005260:Female; D005434:Flow Cytometry; D017228:Hepatocyte Growth Factor / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D008598:Menstruation / Q000378:metabolism; D019859:Proto-Oncogene Proteins c-met / Q000378:metabolism*; D014407:Tumor Cells, Cultured / Q000473:pathology; D019014:fas Receptor / Q000378:metabolism