Monoacetyldiglycerides as new Ca2+ mobilizing agents in rat pancreatic acinar cells.
Several monoacetyldiglycerides were synthesized from glycerol in search for new Ca2+ mobilizing agent in vitro. All monoacetyldiglycerides except linolenoyl and phenlycyclopropylcarbonyl derivatives showed activity toward Ca2+ release in pancreatic acinar cells. Linoleoyl and docosahexaenoyl derivatives were chosen for further test and exhibited unique activity.
Han
S Y
SY
Department of Chemistry, Ewha Womans University, Seoul, Korea. syhan@mm.ewha.ac.kr
Cho
S H
SH
Kim
S Y
SY
Seo
J T
JT
Moon
S J
SJ
Jhon
G J
GJ
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000187:drug effects; D004075:Diglycerides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D010179:Pancreas / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D013329:Structure-Activity Relationship