title: Cytokines and mycoses.
abstract: Cell-mediated immunity (CMI) has been shown, over many decades of clinical observation and bench research, to be central to the outcome of invasive fungal infections. In recent years, understanding the role of messenger molecules (cytokines), in coordinating and augmenting cellular immunity has been ascendant. These studies have made it possible to consider using cytokines, now available in abundant quantities via recombinant DNA technologies, to treat fungal infections. In this symposium, the most important fungal pathogens that cause infections in humans, particularly in immunocompromised patients, are considered, with emphasis on how recent experimental work may lead to a better understanding of the role of cytokines and their use in therapy.
authors.affiliation: Santa Clara Valley Medical Center and Stanford University Medical School, San Jose, CA 95128-2699, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Stevens
authors.forename: T J
authors.initials: TJ
authors.lastname: Walsh
authors.forename: F
authors.initials: F
authors.lastname: Bistoni
authors.forename: E
authors.initials: E
authors.lastname: Cenci
authors.forename: K V
authors.initials: KV
authors.lastname: Clemons
authors.forename: G
authors.initials: G
authors.lastname: Del Sero
authors.forename: C
authors.initials: C
authors.lastname: Fè d'Ostiani
authors.forename: B J
authors.initials: BJ
authors.lastname: Kullberg
authors.forename: A
authors.initials: A
authors.lastname: Mencacci
authors.forename: E
authors.initials: E
authors.lastname: Roilides
authors.forename: L
authors.initials: L
authors.lastname: Romani
mesh_terms: D000818:Animals; D016207:Cytokines / Q000096:biosynthesis / Q000276:immunology* / Q000627:therapeutic use; D005658:Fungi / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007167:Immunotherapy; D051379:Mice; D008807:Mice, Inbred BALB C; D009181:Mycoses / Q000276:immunology* / Q000628:therapy