The prevention and treatment of cutaneous injury secondary to chemical warfare agents. Application of these finding to other dermatologic conditions and wound healing.
Chemical warfare agents are easily and inexpensively produced and are therefore potentially accessible to even underdeveloped nations and are a threat to civilian populations as well as advancing troops. Sulfur mustard is by far the most significant chemical warfare agent that produces cutaneous injury. Significant advances over the past few years have been made in understanding the pathophysiology of the lesions produced by sulfur mustard, as well as development of barrier creams and pre and post exposure therapies to moderate the damage and accelerate healing. Not only have these advances improved our understanding of the sulfur mustard injury and the care of the patients, these are potentially numerous applications for these findings in other dermatologic conditions including the treatment of chronic wounds.
Smith
K J
KJ
Department of Dermatology, National Naval Medical Center, Bethesda, Maryland, USA.
D002057:Burns, Chemical / Q000517:prevention & control / Q000628:therapy; D002619:Chemical Warfare Agents / Q000009:adverse effects*; D006801:Humans; D008889:Military Personnel; D009784:Occupational Diseases / Q000139:chemically induced* / Q000517:prevention & control / Q000628:therapy*; D016273:Occupational Exposure / Q000009:adverse effects*; D012867:Skin / Q000293:injuries*; D012871:Skin Diseases / Q000139:chemically induced* / Q000503:physiopathology; D014481:United States; D014945:Wound Healing