title: Liver assist systems: state of the art.
abstract: Attempts to develop liver support systems for the treatment of patients with liver failure have ranged from use of plasma exchange to utilization of charcoal columns and extracorporeal devices loaded with liver tissue. However, no system has achieved wide clinical use and - in the absence of liver transplantation - severe hepatic failure continues to be associated with significant morbidity and mortality. In this paper, the authors review the current status of liver assist systems and summarize their clinical experience with a xenogeneic cell based-bioartificial liver.
authors.affiliation: Department of Surgery, Cedars-Sinai Medical Center, UCLA School of Medicine, Los Angeles, California 90048, USA.
authors.forename: N
authors.initials: N
authors.lastname: Arkadopoulos
authors.forename: O
authors.initials: O
authors.lastname: Detry
authors.forename: J
authors.initials: J
authors.lastname: Rozga
authors.forename: A A
authors.initials: AA
authors.lastname: Demetriou
mesh_terms: D000818:Animals; D001698:Biomedical Engineering; D004867:Equipment Design; D006801:Humans; D008099:Liver / Q000166:cytology / Q000378:metabolism; D017114:Liver Failure, Acute / Q000503:physiopathology / Q000628:therapy*; D019164:Liver, Artificial