Effects of brimonidine 0.2% on blue-yellow perimetry of glaucomatous patients.
A cross-over double-blind study was performed to evaluate the effect of acute administration of brimonidine on the blue-yellow perimetry. Thirty patients with primary open-angle glaucoma were admitted. After brimonidine administration, IOP and pupil diameter showed a significant reduction (p < 0.01) without modification in systolic and diastolic blood pressure. Blue-on-yellow perimetry showed a significant reduction in CPSD from 3.81 +/- 1.60 to 2.71 +/- 1.92 (p < 0.05). This result suggests that brimonidine improves ocular perfusion via a reduction of IOP.
Mastropasqua
L
L
Institute of Ophthalmology, Gabriele D'Annunzio University, Chieti.
Ciancaglini
M
M
Carpineto
P
P
Zuppardi
E
E
Falconio
G
G
Gallenga
P E
PE
D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage / Q000627:therapeutic use*; D001082:Aqueous Humor / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D000068438:Brimonidine Tartrate; D015350:Contrast Sensitivity / Q000187:drug effects; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D009883:Ophthalmic Solutions / Q000008:administration & dosage / Q000627:therapeutic use; D011680:Pupil / Q000187:drug effects; D011810:Quinoxalines / Q000008:administration & dosage / Q000627:therapeutic use*; D058609:Visual Field Tests; D014794:Visual Fields / Q000187:drug effects*