[Effects of hypertonic lactated Ringer's solution on hepatic ATP and L/P ratio in rats subjected to acute hemorrhage].
This study aimed to clarify the difference in the effects of hypertonic lactated Ringer's solution (HLS) on hepatic ATP level and L/P ratio during acute hemorrhage in rats. The hepatic ATP level in HLS 230 group was lower, and L/P ratio in HLS 300 group was higher than those in the control group. There was no significant difference in glycogen among 4 groups. However, pH and the base excess in HLS 230 and HLS 300 group were significantly higher than those in the C group. Heart rate in HLS 300 group was significantly lower than that in the C group. These results suggest that HLS may not be useful with regard to the hepatic energy metabolism, although it improves the metabolic acidosis during acute hemorrhage.
Ikeya
K
K
Department of Anesthesia, Suwa Central Hospital, Nagano.
Kashimoto
S
S
Kume
M
M
Kumazawa
T
T
D000208:Acute Disease; D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D004734:Energy Metabolism / Q000187:drug effects; D006003:Glycogen / Q000378:metabolism; D006470:Hemorrhage / Q000378:metabolism*; D006982:Hypertonic Solutions; D007552:Isotonic Solutions / Q000494:pharmacology*; D019344:Lactic Acid / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D019289:Pyruvic Acid / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D000077325:Ringer's Lactate