title: Elevated levels of human salivary epidermal growth factor after oral and juxtaoral surgery.
abstract: OBJECTIVE
  Saliva provides a natural reservoir of growth factors whose purposes have remained elusive. Animal studies suggest that saliva-derived growth factors play a role in systemic and oral wound healing. In the current study, salivary concentrations of epidermal growth factor (EGF) were monitored in patients before and after oral and juxtaoral surgery.
  
  
  METHODS
  Whole resting saliva was collected from a group of patients with parotid gland tumors requiring surgical resection. Another group of patients a history of periodontal disease requiring surgical intervention also provided whole salivary samples. Healthy age- and sex-matched persons served as controls.
  
  
  RESULTS
  Salivary EGF levels were elevated in both groups of patients within 24 hours after surgery. In the periodontitis patients, a second smaller peak was assayed noted between 36 and 48 hours. After this, EGF concentrations returned to levels comparable to healthy controls in both experimental groups.
  
  
  CONCLUSIONS
  Although the local cells have the ability to synthesize and secrete growth factors at a site of injury, these results suggest that surgery stimulates increased synthesis and secretion of growth factors in the saliva as well. This increased level of saliva-derived growth factor may also aid in promoting wound healing.
authors.affiliation: Department of Periodontology, University of Florida, Gainesville 32610-0434, USA.
authors.forename: G E
authors.initials: GE
authors.lastname: Oxford
authors.forename: R
authors.initials: R
authors.lastname: Jonsson
authors.forename: J
authors.initials: J
authors.lastname: Olofsson
authors.forename: T
authors.initials: T
authors.lastname: Zelles
authors.forename: M G
authors.initials: MG
authors.lastname: Humphreys-Beher
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D016022:Case-Control Studies; D004815:Epidermal Growth Factor / Q000032:analysis* / Q000096:biosynthesis / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010307:Parotid Neoplasms / Q000601:surgery*; D010518:Periodontitis / Q000601:surgery*; D012463:Saliva / Q000737:chemistry* / Q000378:metabolism; D013053:Spectrophotometry; D014945:Wound Healing