Update on androgenicity.
The development of a new generation of progestins deemed less androgenic than their earlier counterparts has led to a number of misconceptions regarding their possible benefits in combination oral contraceptives. All combination oral contraceptives are beneficial for treating such androgenic conditions as acne and hirsutism. The only expressed androgenic effect of some first- and second-generation combined oral contraceptives are changes in plasma lipid and lipoprotein levels. However, the overall effect of today's low-dose oral contraceptives is largely lipid neutral, and human and monkey studies have shown that oral contraceptive use is associated with reduced, not increased, atherosclerosis rates. Myocardial infarction rates are not increased among oral contraceptive users, except among those who are heavy smokers.
Thorneycroft
I H
IH
Department of Obstetrics and Gynecology, University of South Alabama, Mobile 36617, USA.
D000152:Acne Vulgaris / Q000188:drug therapy; D000728:Androgens / Q000009:adverse effects*; D002318:Cardiovascular Diseases / Q000139:chemically induced; D003271:Contraceptive Agents, Female; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004967:Estrogens / Q000627:therapeutic use; D005260:Female; D006801:Humans; D011372:Progestins / Q000009:adverse effects*; D012307:Risk Factors