title: Isolated case of Ebola hemorrhagic fever with mucormycosis complications, Kinshasa, Democratic Republic of the Congo.
abstract: A patient with undiagnosed Ebola (EBO) hemorrhagic fever (EHF) was transferred from Kikwit to a private clinic in Kinshasa, Democratic Republic of the Congo. A diagnosis of EHF was suspected on clinical grounds and was confirmed by detection of EBO virus-specific IgM and IgG in serum of the patient. During the course of the disease, although she had no known predisposing factors, the patient developed a periorbital mucormycosis abscess on eyelid tissue that was biopsied during surgical drainage; the abscess was histologically confirmed. Presence of EBO antigen was also detected by specific immunohistochemistry on the biopsied tissue. The patient survived the EBO infection but had severe sequelae associated with the mucormycosis. Standard barrier-nursing precautions were taken upon admission and upgraded when EHF was suspected; there was no secondary transmission of the disease.
authors.affiliation: Médecine Interne, Clinique Bondeko, Kinshasa-Limete, Democratic Republic of the Congo.
authors.forename: Y
authors.initials: Y
authors.lastname: Kalongi
authors.forename: K
authors.initials: K
authors.lastname: Mwanza
authors.forename: M
authors.initials: M
authors.lastname: Tshisuaka
authors.forename: N
authors.initials: N
authors.lastname: Lusiama
authors.forename: E
authors.initials: E
authors.lastname: Ntando
authors.forename: L
authors.initials: L
authors.lastname: Kanzake
authors.forename: W J
authors.initials: WJ
authors.lastname: Shieh
authors.forename: S R
authors.initials: SR
authors.lastname: Zaki
authors.forename: E S
authors.initials: ES
authors.lastname: Lloyd
authors.forename: T G
authors.initials: TG
authors.lastname: Ksiazek
authors.forename: P E
authors.initials: PE
authors.lastname: Rollin
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D000956:Antigens, Viral / Q000378:metabolism; D001766:Blindness / Q000209:etiology; D015023:Democratic Republic of the Congo; D029043:Ebolavirus / Q000276:immunology / Q000302:isolation & purification; D005141:Eyelid Diseases / Q000150:complications / Q000382:microbiology / Q000821:virology; D005260:Female; D019142:Hemorrhagic Fever, Ebola / Q000150:complications* / Q000175:diagnosis / Q000821:virology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D009091:Mucormycosis / Q000150:complications* / Q000382:microbiology / Q000821:virology; D009894:Opportunistic Infections / Q000150:complications / Q000382:microbiology / Q000821:virology