Mapping susceptibility genes for asthma and allergy.
Using family data, linkage analysis has been performed to determine the location in the genome of susceptibility genes for allergy and asthma. It has now become clear that there are multiple regions of the genome that contain susceptibility genes for allergy and asthma. The results from two genome screen studies will be reviewed and compared with results from candidate gene approaches. Results from several studies show evidence for linkage to chromosomes 5, 6, 11, 12, 13 and 14 for atopy, asthma or a related phenotype such as total serum IgE levels. Many of these regions contain candidate genes involved in regulating processes that may be involved in the development or progression of allergy and asthma. Some susceptibility genes may affect the expression of these disorders while others may affect response to therapy. Susceptibility to developing allergy or asthma appears to be due to the interaction of multiple genes with the environment.
Bleecker
E R
ER
Center for the Genetics of Asthma and Complex Diseases, University of Maryland, Baltimore 21201, USA.
D001249:Asthma / Q000235:genetics*; D002874:Chromosome Mapping; D002877:Chromosomes, Human; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics*; D020412:Multifactorial Inheritance