title: Synthesis and biological activity of KCB-328 and its analogues: novel class III antiarrhythmic agents with little reverse frequency dependence.
abstract: A series of 3,4-dimethoxyphenethylamine derivatives was prepared, and their prolongation effects on effective refractory period of contractile response (ERPc) and action potential duration (APD) in isolated guinea-pig papillary muscles at 1 Hz and 3 Hz were examined. SAR studies led to the identification of KCB-328 (51) which is a novel class III antiarrhythmic agent with little reverse frequency dependence.
authors.affiliation: C&C Research Laboratories, Kyunggi-do, Korea.
authors.forename: D I
authors.initials: DI
authors.lastname: Kim
authors.forename: H Y
authors.initials: HY
authors.lastname: Kim
authors.forename: L S
authors.initials: LS
authors.lastname: Kwon
authors.forename: S D
authors.initials: SD
authors.lastname: Park
authors.forename: G H
authors.initials: GH
authors.lastname: Jeon
authors.forename: K Y
authors.initials: KY
authors.lastname: Jung
authors.forename: J K
authors.initials: JK
authors.lastname: Min
authors.forename: W H
authors.initials: WH
authors.lastname: Nam
authors.forename: K
authors.initials: K
authors.lastname: Lee
authors.forename: Y S
authors.initials: YS
authors.lastname: Chung
authors.forename: S
authors.initials: S
authors.lastname: Tanabe
authors.forename: T
authors.initials: T
authors.lastname: Kozono
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D010210:Papillary Muscles / Q000187:drug effects; D010627:Phenethylamines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*