Application of chemically modified tetracyclines (CMTs) in experimental models of cancer and arthritis.
Seftor
E A
EA
Department of Anatomy and Cell Biology, University of Iowa College of Medicine, Iowa City, USA.
Seftor
R E
RE
Nieva
D R
DR
Hendrix
M J
MJ
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000201:enzymology*; D002358:Cartilage, Articular / Q000502:physiology; D017077:Culture Media, Conditioned; D004305:Dose-Response Relationship, Drug; D004318:Doxycycline / Q000494:pharmacology; D005260:Female; D005347:Fibroblasts / Q000187:drug effects; D018093:Gelatinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000556:secondary*; D008545:Melanoma / Q000188:drug therapy* / Q000201:enzymology* / Q000473:pathology; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors; D051379:Mice; D016513:Mice, SCID; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D011480:Protease Inhibitors / Q000494:pharmacology*; D013583:Synovial Membrane / Q000166:cytology / Q000187:drug effects / Q000201:enzymology; D013754:Tetracyclines / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D014407:Tumor Cells, Cultured / Q000187:drug effects