title: Algorithm for the surgical treatment of malignant lesions of the proximal tibia.
abstract: Complications are common among patients treated for malignant lesions of the proximal tibia and can be difficult to manage. This investigation was a retrospective review of 40 patients treated with total knee replacements after proximal tibial resections. Various reconstructive methods were used to fix the prosthetic stems, reestablish the extensor mechanism, and provide soft tissue coverage. Thirty-one patients had adequate followup to allow for review of prosthetic outcome (means, 78 months; range, 25-193 months). Seven patients died with less than 2 years followup, and two patients had postoperative acute infections treated by early amputation to allow chemotherapy to resume promptly. The overall 5-, 8-, and 12-year event free prostheses survival rates were 62%, 33%, and 16%, respectively. Prognostic factors for prosthetic survival were analyzed (age, gender, type of excision, type of prosthesis, type of fixation, and percent of bone resected). None were statistically significant. Patients with less than 40% of the tibia resected had better prosthetic survival at 5 years. The durability of uncemented stem fixation exceeded that of cemented stems. Expected survival of prostheses after revision was 52% at 8 years. The major cause of limb loss was infection. Failure to reconstruct soft tissues satisfactorily caused most failures. Aggressive multistage management of infection is needed. Prosthetic knee replacement is most suitable for patients with cancers that require chemotherapy and for those patients who have short potential survival.
authors.affiliation: Department of Orthopaedic Surgery, Korea Cancer Center Hospital, Seoul, Korea.
authors.forename: D G
authors.initials: DG
authors.lastname: Jeon
authors.forename: A
authors.initials: A
authors.lastname: Kawai
authors.forename: P
authors.initials: P
authors.lastname: Boland
authors.forename: J H
authors.initials: JH
authors.lastname: Healey
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000465:Algorithms; D019645:Arthroplasty, Replacement, Knee; D001859:Bone Neoplasms / Q000401:mortality / Q000601:surgery*; D002648:Child; D006801:Humans; D008875:Middle Aged; D011183:Postoperative Complications; D011475:Prosthesis Failure; D012189:Retrospective Studies; D016019:Survival Analysis; D013977:Tibia; D016896:Treatment Outcome