Nutritional effects of a D-methionine-containing solution on AH109A hepatoma-bearing rats.
The effects of a D-methionine-containing solution (DMCS) on the nutritional status of AH109A hepatomabearing rats receiving total parenteral nutrition were studied. The DMCS solution inhibited the decrease of transferrin in the plasma of tumor-bearing rats when compared with the effect of an L-methionine-containing solution. The survival time was also significantly prolonged in the DMCS-treated rats. These results indicate that DMCS had a beneficial effect on the malnutrition induced in tumor-bearing rats and would be a useful amino acid solution for the nutritional support of cancer patients.
Sasamura
T
T
Infusion Research Department, Hoechst Marion Roussel Ltd., Saitama, Japan.
Matsuda
A
A
Kokuba
Y
Y
D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D001798:Blood Proteins / Q000032:analysis; D001835:Body Weight; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000378:metabolism*; D005526:Food, Formulated / Q000592:standards; D008114:Liver Neoplasms, Experimental / Q000150:complications / Q000378:metabolism*; D008297:Male; D008715:Methionine / Q000737:chemistry / Q000378:metabolism*; D009748:Nutrition Disorders / Q000517:prevention & control; D009752:Nutritional Status; D010289:Parenteral Nutrition, Total / Q000592:standards*; D051381:Rats; D012709:Serum Albumin / Q000032:analysis; D014168:Transferrin / Q000032:analysis