Association between cytosolic low molecular weight phosphotyrosine-phosphatase and malaria--a possible mechanism.
Cytosolic low molecular weight phosphotyrosine-phosphatase shows dephosphorylating activity of the band 3 protein. Increased phosphorylation of this protein increases membrane rigidity and resistance to invasion of red blood cells by malarial parasites. This observation may explain the negative association previously reported by our group between the high activity *C allele of cytosolic low molecular weight phosphotyrosine-phosphatase and past malarial morbidity.
Bottini
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University of Rome Tor Vergata, School of Medicine, Roma, Italy. bottini@med.uniroma2.it
D000293:Adolescent; D000483:Alleles; D001457:Anion Exchange Protein 1, Erythrocyte / Q000378:metabolism*; D002462:Cell Membrane / Q000502:physiology; D002648:Child; D003600:Cytosol; D004912:Erythrocytes / Q000502:physiology; D005260:Female; D006790:Host-Parasite Interactions; D006801:Humans; D007113:Immunity, Innate; D008288:Malaria / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D008297:Male; D017027:Protein Tyrosine Phosphatases / Q000235:genetics / Q000378:metabolism*