A study of novel antiallergic agents with eosinophilic infiltration inhibiting action.
The antiallergic action of a series of novel mono-O-substituted trimethylhydroquinones was investigated. Among this series of the compounds, 4-[4-[4-(diphenylmethyl)-1-piperazinyl]butoxy]-2,3,6- trimethylphenol (compound 3) showed a potent antihistaminic action (pA2 = 7.11) and an antiasthmatic action (100 mg/kg. p.o) on sensitized guinea pigs. Moreover, this compound exhibited a strong eosinophilic infiltration inhibiting action on sensitized mice (100 mg/kg p.o.).
Kawasaki
N
N
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
Miyataka
H
H
Matsumoto
H
H
Yamashita
N
N
Sakane
T
T
Mizushima
Y
Y
Satoh
T
T
D000418:Albumins / Q000276:immunology; D000818:Animals; D018926:Anti-Allergic Agents / Q000737:chemistry / Q000494:pharmacology*; D018927:Anti-Asthmatic Agents / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004804:Eosinophils / Q000187:drug effects*; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000737:chemistry / Q000494:pharmacology; D007082:Ileum / Q000187:drug effects; D016859:Lipoxygenase Inhibitors; D008168:Lung / Q000473:pathology; D051379:Mice; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology*; D010879:Piperazines / Q000737:chemistry / Q000494:pharmacology*; D011738:Pyrilamine / Q000494:pharmacology; D051381:Rats; D012119:Respiration / Q000187:drug effects; D012137:Respiratory System / Q000187:drug effects