title: Defibrillation efficacy of different electrode placements in a human thorax model.
abstract: The objective of this study was to measure the defibrillation threshold (DFT) associated with different electrode placements using a three-dimensional anatomically realistic finite element model of the human thorax. Coil electrodes (Endotak DSP, model 125, Guidant/CPI) were placed in the RV apex along the lateral wall (RV), withdrawn 10 mm away from the RV apex along the lateral wall (RVprox), in the RV apex along the anterior septum (RVseptal), and in the SVC. An active pulse generator (can) was placed in the subcutaneous prepectoral space. Five electrode configurations were studied: RV-->SVC, RVprox-->SVC, RVSEPTAL-->SVC, RV-->Can, and RV-->SVC + Can. DFTs are defined as the energy required to produce a potential gradient of at least 5 V/cm in 95% of the ventricular myocardium. DFTs for RV-->SVC, RVprox-->SVC, RVseptal-->SVC, RV-->Can, and RV-->SVC + Can were 10, 16, 7, 9, and 6 J, respectively. The DFTs measured at each configuration fell within one standard deviation of the mean DFTs reported in clinical studies using the Endotak leads. The relative changes in DFT among electrode configurations also compared favorably. This computer model allows measurements of DFT or other defibrillation parameters with several different electrode configurations saving time and cost of clinical studies.
authors.affiliation: Department of Biomedical Engineering, University of Memphis, Tennessee 38152-6582, USA.
authors.forename: A L
authors.initials: AL
authors.lastname: de Jongh
authors.forename: E G
authors.initials: EG
authors.lastname: Entcheva
authors.forename: J A
authors.initials: JA
authors.lastname: Replogle
authors.forename: R S
authors.initials: RS
authors.lastname: Booker
authors.forename: B H
authors.initials: BH
authors.lastname: Kenknight
authors.forename: F J
authors.initials: FJ
authors.lastname: Claydon
mesh_terms: D003198:Computer Simulation; D017147:Defibrillators, Implantable; D004554:Electric Countershock / Q000295:instrumentation*; D006325:Heart Atria / Q000033:anatomy & histology; D006329:Heart Conduction System / Q000033:anatomy & histology; D006352:Heart Ventricles / Q000033:anatomy & histology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008955:Models, Cardiovascular; D012016:Reference Values; D017180:Tachycardia, Ventricular / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D013909:Thorax / Q000033:anatomy & histology*