title: [Granulocyte colony-stimulating factor in the newborn neutropenic patient].
abstract: OBJECTIVE
  To assess the therapeutic effect of G-CSF in newborns with neutropenia.
  
  
  METHODS
  Newborn with evidence of both peripheral neutropenia and decreased granulocytic precursors in tibial bone marrow aspirate were included in the study. G-CSF was perfused intravenously over 2 hours at dose of 10 micrograms/kg/day, during 4-8 days. CBC were obtained immediately before each dose of G-CSF.
  
  
  RESULTS
  Neutropenia followed neonatal sepsis in four cases and maternal pre-eclampsia in three. Prior to treatment, peripheral blood granulocyte (PMNL) counts ranged from 420 to 1,073/mm3. Once G-CSF infusion was started, counts returned to normal within 24-48 hours. No adverse effects related to G-CSF administration were noticed.
  
  
  CONCLUSIONS
  G-CSF induces a significant increase in peripheral PMNL counts in newborn with neutropenia, in the absence of significant toxic effects. Our date suggest a potential role for G-CSF in the prophylaxis and treatment of sepsis in the neutropenic newborn, although widespread recommendation must await further, controlled studies.
authors.affiliation: Servicio de Neonatología, Hospital Universitario Materno-Infantil Valle Hebrón, Barcelona.
authors.forename: F
authors.initials: F
authors.lastname: Castillo Salinas
authors.forename: C
authors.initials: C
authors.lastname: Díaz de Heredia Rubio
authors.forename: S
authors.initials: S
authors.lastname: Salcedo Abizanda
authors.forename: A
authors.initials: A
authors.lastname: Ferrer Comalat
authors.forename: P
authors.initials: P
authors.lastname: Bastida Vila
authors.forename: J J
authors.initials: JJ
authors.lastname: Ortega Aramburu
authors.forename: G
authors.initials: G
authors.lastname: Peguero Monforte
mesh_terms: D003131:Combined Modality Therapy; D004341:Drug Evaluation; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D007958:Leukocyte Count / Q000187:drug effects; D009503:Neutropenia / Q000097:blood / Q000188:drug therapy*; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects; D011994:Recombinant Proteins; D013997:Time Factors