The influence of epsilon-aminocaproic acid derivatives on the anticoagulant activity of heparin.
Derivatives of epsilon-aminocaproic acid with antifibrinolytic activity, at low concentration, do not influence the anticoagulant activity of heparin under the heparin-thrombin test conditions. At concentrations higher than 0.002 M tested compounds slightly enhance the anticoagulant action of heparin.
Midura-Nowaczek
K
K
Institute of Chemistry, University of Bialystok, Poland.
Bruzgo
I
I
Worowski
K
K
Roszkowska-Jakimiec
W
W
D000614:Aminocaproates / Q000494:pharmacology*; D000925:Anticoagulants / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006493:Heparin / Q000494:pharmacology*; D006801:Humans