title: Lung volume reduction surgery for severe emphysema.
abstract: BACKGROUND
  We report mid-term results after 25 consecutive lung volume reduction operations (LVRS) for the treatment of severe dyspnea due to advanced emphysema.
  
  
  METHODS
  
  
  
  METHODS
  patients were studied prospectively up to 12 months after surgery.
  
  
  METHODS
  preoperative evaluation, surgery and postoperative care took place in our university hospital.
  
  
  METHODS
  patient selection was based on severe dyspnea and airway obstruction despite optimal medical treatment, lung overinflation and completed rehabilitation programme. PATIENTS with severe hypercarbia (PCO2>50 mmHg) were excluded. Nineteen rehabilitated patients who fulfilled our inclusion criteria but postponed or denied LVRS were followed up clinically.
  
  
  METHODS
  LVRS was performed bilaterally in 22 patients (median sternotomy) and unilaterally in 3 patients (limited thoracotomy).
  
  
  METHODS
  Outcome was measured by dyspnea evaluation, 6-minute-walking distance and pulmonary function tests.
  
  
  RESULTS
  Twelve months postoperatively dyspnea and mobility improved significantly (MRC score from 3.3+/-0.7 to 2.12+/-0.8, 6-min-walk from 251+/-190 to 477+/-189 m). These results were superior compared to the results of the conservatively treated patients. Significant improvement could also be documented in airway obstruction (FEV1 from 960+/-369 to 1438+/-610 ml) and overinflation (TLC from 133+/-14 to 118+/-21% predicted and RV from 280+/-56 to 186+/-59% predicted).
  
  
  CONCLUSIONS
  LVRS is an effective and promising treatment option for selected patients with end-stage emphysema and could be offered as an alternative and / or bridge to lung transplantation.
authors.affiliation: Department of Thoracic & Cardiovascular Surgery, University Hospital Homburg/Saar, Saarland University, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Demertzis
authors.forename: H
authors.initials: H
authors.lastname: Wilkens
authors.forename: M
authors.initials: M
authors.lastname: Lindenmeir
authors.forename: T
authors.initials: T
authors.lastname: Graeter
authors.forename: H J
authors.initials: HJ
authors.lastname: Schäfers
mesh_terms: D004417:Dyspnea / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy / Q000379:methods; D011446:Prospective Studies; D011656:Pulmonary Emphysema / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D012129:Respiratory Function Tests; D016896:Treatment Outcome