Synergistic effect of naphthoquinones on the mutagenicity of nitroarene.
Nitro reduction is a critical step in the mutagenic activation of nitroarene. Nitroarene and quinone are known to be reduced by common enzymes, and thus, naphthoquinone (NQ) was studied for its effects on the mutagenicity of nitroarene in the Ames test using Salmonella typhimurium TA98 without S9. The mutagenicity of 1,3-dinitropyrene in TA98 was found to increase 9- and 6-fold as much in the presence of 70 nmol/plate of 2-methyl-1,4-NQ and 2-hydroxy-1,4-NQ, respectively. Mutagenicity also became greater in 1,3,5-trinitronaphthalene, 1-nitropyrene and 3-nitrofluoranthene. Seventy nmol/plate of 2-methyl-1,4-NQ increased the mutagenicity of 1-nitropyrene by 10.5-fold as much.
Ohmori
K
K
Kanagawa Prefectural Health Laboratory, Yokohama, Japan.
Kishi
M
M
Nakaoka
T
T
Miyata
N
N
D004357:Drug Synergism; D005449:Fluorenes / Q000633:toxicity*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D009281:Naphthalenes / Q000633:toxicity*; D009285:Naphthoquinones / Q000633:toxicity*; D009574:Nitro Compounds / Q000633:toxicity*; D011721:Pyrenes / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics