Lack of effect of apolipoprotein E E4 allele on neuropsychiatric manifestations in Alzheimer's disease.
The association between the apolipoprotein E epsilon 4 (APOE E4) allele and a wide spectrum of behavioral symptoms of Alzheimer's disease (AD) was investigated. Neither the severity nor the presence of any behavioral changes was associated with the number of APOE E4 alleles, even after controlling for the effects of age at onset, sex, education level, duration of illness, and severity of dementia. The findings do not support the hypothesis that neuropsychiatric manifestations of AD are different in patients with the APOE E4 allele.
Hirono
N
N
Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan. hirono@hiabcd.go.jp
Mori
E
E
Yasuda
M
M
Imamura
T
T
Shimomura
T
T
Hashimoto
M
M
Tanimukai
S
S
Kazui
H
H
Yamashita
H
H
D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D001526:Behavioral Symptoms / Q000235:genetics*; D016001:Confidence Intervals; D005260:Female; D018628:Gene Dosage; D006801:Humans; D007564:Japan; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D010641:Phenotype; D016133:Polymerase Chain Reaction; D011569:Psychiatric Status Rating Scales