A lower rate of preterm birth after clotrimazole therapy during pregnancy.
Topical or vaginal clotrimazole treatment during pregnancy was evaluated in the large population-based control data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-92. The database comprised 32,804 control non-malformed newborn infants, 7.7% of whom were born to mothers who had received clotrimazole treatment during pregnancy. An increase in mean gestational age among exposed vs. unexposed was found. It is postulated that the use of clotrimazole during pregnancy reduced significantly the proportion of preterm births because of the effective treatment of genital infections caused by candidiasis in pregnant women.
Czeizel
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Department of Human Genetics and Teratology, National Institute of Public Health-WHO Collaborating Centre for the Community Control of Hereditary Diseases, Budapest, Hungary.
Rockenbauer
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M
D000328:Adult; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001724:Birth Weight / Q000187:drug effects; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy*; D003022:Clotrimazole / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D007231:Infant, Newborn; D016015:Logistic Models; D007752:Obstetric Labor, Premature / Q000453:epidemiology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D012189:Retrospective Studies