Selected animal models: vaginal candidosis, Pneumocystis pneumonia, dermatophytosis and trichosporosis.
A clear understanding of the pathogenesis of fungal disease remains elusive. While technological advances in molecular biology and microbial genetics have provided scientists with major new insights into both microbial virulence factors as well as host susceptibility to infection, there is currently no substitute for animal models in elucidating microbe-host interactions. Animal models are also essential for the evaluation of new antimicrobial agents, including studies of efficacy, adverse reactions and pharmacokinetics. The single most important advance in animal models in the last decade, has been the availability of genetically unique strains of animals as alternative to animals treated with immunosuppressive drugs for use in studies on microbial virulence and host defence mechanisms. These unique strains of test animals also enhance our understanding of the modes of action of antifungal drugs and their metabolism. Some of these advances will be discussed in this symposium.
Sobel
J D
JD
Division of Infectious Diseases, Wayne State University, Detroit, MI, USA.
Hasegawa
A
A
Debernardis
F
F
Adriani
D
D
Pellegrini
G
G
Cassone
A
A
Fidel
P L
PL
Haidaris
C G
CG
Gigliotti
F
F
Harmsen
A G
AG
Fujita
S
S
Yamamoto
K
K
Makimura
K
K
Shibuya
K
K
Uchida
K
K
Yamaguchi
H
H
D000818:Animals; D002181:Candidiasis, Vulvovaginal / Q000276:immunology / Q000382:microbiology; D003881:Dermatomycoses / Q000276:immunology / Q000382:microbiology; D004195:Disease Models, Animal; D005260:Female; D005658:Fungi / Q000472:pathogenicity; D006801:Humans; D009181:Mycoses / Q000276:immunology / Q000382:microbiology; D011020:Pneumonia, Pneumocystis / Q000276:immunology / Q000382:microbiology; D014008:Tinea Pedis / Q000382:microbiology; D014250:Trichosporon / Q000472:pathogenicity; D014774:Virulence