title: Spectra of spontaneous growth-dependent and adaptive mutations at ebgR.
abstract: A comparison of the spectra of spontaneous growth-dependent and adaptive mutations in ebgR shows that both spectra are dominated by insertion sequence (IS)-mediated mutations. The difference between growth-dependent mutations (61% IS mediated) and adaptive mutations (80% IS mediated) is highly significant (P < 0.0001). In contrast, the spectra of growth-dependent and adaptive non-IS-mediated mutations do not differ from each other and therefore do not provide support for the hypothesis that adaptive and growth-dependent mutations arise by substantially different mechanisms.
authors.affiliation: University of Rochester, Rochester, New York. drbh@uhura.cc.rochester.edu
authors.forename: B G
authors.initials: BG
authors.lastname: Hall
mesh_terms: D000220:Adaptation, Biological / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics* / Q000254:growth & development; D029968:Escherichia coli Proteins; D008957:Models, Genetic; D016296:Mutagenesis / Q000235:genetics*; D016254:Mutagenesis, Insertional / Q000235:genetics; D016133:Polymerase Chain Reaction; D012097:Repressor Proteins / Q000235:genetics*; D017422:Sequence Analysis, DNA; D001616:beta-Galactosidase / Q000096:biosynthesis / Q000235:genetics