Evaluation of the fungitest kit by using strains from human immunodeficiency virus-infected patients: study of azole drug susceptibility.
One hundred eighteen Candida clinical isolates from human immunodeficiency virus-infected patients were tested for their susceptibilities to fluconazole and itraconazole by Fungitest and the National Committee for Clinical Laboratory Standards MIC method. Fungitest results depended on both yeast species and antifungal agents. This test is able to detect sensitive strains (97% agreement with results of the MIC method in tests with fluconazole and 84% agreement in tests with itraconazole) but has a poor capacity to detect resistant strains (26% agreement in tests with fluconazole and 5% agreement in tests with itraconazole).
Witthuhn
F
F
Laboratoire de Parasitologie-Mycologie, Equipe 4 INSERM U 314, EA 2070, IFR 53, Centre Hospitalier Universitaire de Reims, France.
Toubas
D
D
Béguinot
I
I
Aubert
D
D
Rouger
C
C
Remy
G
G
Pinon
J M
JM
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002175:Candida / Q000145:classification* / Q000187:drug effects / Q000302:isolation & purification; D002176:Candida albicans / Q000187:drug effects; D002177:Candidiasis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D015725:Fluconazole / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D017964:Itraconazole / Q000494:pharmacology* / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests; D009172:Mycology / Q000379:methods; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity