Synthesis and methemoglobin toxicity of the amides of 6/7 mono or disubstituted quinolone.
A series of 6/7-mono and disubstituted quinolone-3-carboxamide derivatives (1-12) were synthesized and their in vitro methemoglobin producing capacity have been delineated. The compounds 5, 6, 9 and 10 showed minimum methemoglobin toxicity.
Srivastava
S
S
Division of Biochemistry, Central Drug Research Institute, Lucknow, India.
Srivastava
S K
SK
Shukla
A
A
Chauhan
P M
PM
Puri
S K
SK
Bhaduri
A P
AP
Pandey
V C
VC
D000577:Amides / Q000737:chemistry; D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology; D042966:Cytochrome-B(5) Reductase / Q000187:drug effects / Q000378:metabolism; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D008706:Methemoglobin / Q000032:analysis / Q000187:drug effects*; D008708:Methemoglobinemia / Q000139:chemically induced; D009643:Norfloxacin / Q000494:pharmacology; D015242:Ofloxacin / Q000494:pharmacology; D015363:Quinolones / Q000138:chemical synthesis* / Q000633:toxicity*; D013329:Structure-Activity Relationship