[Hormones and auto-paracrine tumor growth regulators in osteogenic sarcoma].
The paper analyzes the data of long-term studies made in the N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences. The study dealt with androgen exchange, the baseline levels of serum sexual steroid hormones and their receptors in the tumor, the blood concentrations of the sexual steroids conjugated globulin and pituitary hormone, the metabolism of arachidonic acid, the expression of epidermal growth factor and its ligands, the amount of calmodulin, cAMP in the osteogenic sarcoma in 300 patients aged 14-56 years. Analyzing the findings suggests that there are some directions in studies, development, and practical introduction of new pathogenetic therapies of osteosarcoma, which are associated with the regulation of androgen exchange, the correction of the cyclooxygenase pathway of arachidonic acid, expression of receptors of epidermal growth factor and its ligands in the tumor.
Kushlinskiĭ
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D000293:Adolescent; D000328:Adult; D000818:Animals; D014408:Biomarkers, Tumor; D001859:Bone Neoplasms / Q000378:metabolism* / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000378:metabolism* / Q000473:pathology; D019899:Paracrine Communication; D011379:Prognosis; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism