Suppressed apoptotic susceptibility in human endometrial epithelial cells pretreated with hepatocyte growth factor.
Hepatocyte growth factor (HGF) and its receptor are strongly expressed perimenstrually in human endometrial epithelium, but their functions remain unknown. In this study the effects of HGF on Fas-mediated apoptosis in the human endometrial epithelial cell line HHUA were investigated. It was found that HGF inhibited Fas-mediated growth suppression and DNA fragmentation in the cells without any increase in Fas antigen expression on the cells. This results suggests that HGF inhibits Fas-mediated apoptotic signals in the endometrium, and possibly plays a role in reshaping the endometrium during menstruation.
Tanaka
T
T
Department of Obstyetrics & Gynecology, Osaka City University Medical School, Japan.
Mizuno
K
K
Umesaki
N
N
Ogita
S
S
D000230:Adenocarcinoma / Q000473:pathology*; D017209:Apoptosis; D002455:Cell Division / Q000187:drug effects; D053938:DNA Fragmentation; D004305:Dose-Response Relationship, Drug; D016889:Endometrial Neoplasms / Q000473:pathology*; D004717:Endometrium / Q000166:cytology* / Q000187:drug effects; D004848:Epithelium / Q000473:pathology; D005260:Female; D005434:Flow Cytometry; D017228:Hepatocyte Growth Factor / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D008598:Menstruation / Q000378:metabolism; D019859:Proto-Oncogene Proteins c-met / Q000378:metabolism*; D014407:Tumor Cells, Cultured / Q000473:pathology; D019014:fas Receptor / Q000378:metabolism