Lymphocytic autoimmune hidradenitis, cutaneous leucocytoclastic vasculitis and primary Sjögren's syndrome.
We describe a 60-year-old woman with primary Sjögren's syndrome, mixed cryoglobulinaemia and cutaneous leucocytoclastic vasculitis who developed generalized hypohidrosis with a markedly decreased sweating response to pilocarpine chloride. Skin biopsies demonstrated dense peri-eccrine lymphocytic infiltrates in the lower reticular dermis, with glandular atrophy. From previous studies it is evident that although patients with Sjögren's syndrome commonly have skin dryness, a lymphocytic hidradenitis has been documented only in a few cases. The histological findings in this case support the role of autoimmune hidradenitis in the development of hypohidrosis in Sjögren's syndrome.
Sais
G
G
Department of Dermatology, Consorci Sanitari de Mataró, Barcelona, Spain.
Admella
C
C
Fantova
M J
MJ
Montero
J C
JC
D001327:Autoimmune Diseases / Q000209:etiology* / Q000473:pathology; D001707:Biopsy, Needle; D005260:Female; D016575:Hidradenitis / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D012859:Sjogren's Syndrome / Q000150:complications* / Q000473:pathology; D012867:Skin / Q000098:blood supply; D014657:Vasculitis / Q000209:etiology* / Q000473:pathology