Cytochrome P450 in parasitic protozoa and helminths.
Cytochrome P450 has been demonstrated in flagellate and sporozoan Protozoa. In Plasmodium there is a correlation between chloroquine resistance and cytochrome P450 mono-oxygenase activity, but there is no evidence that the malarial parasite metabolises chloroquine by an oxidative mechanism. There is no evidence for cytochrome P450 in adult helminths (nematodes and platyhelminths) based on P450 content and mono-oxygenase activity with classical substrates, although low activities may be present in free-living larval stages.
Barrett
J
J
Institute of Biological Sciences, University of Wales, Aberystwyth, Ceredigion, UK.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D056890:Eukaryota / Q000201:enzymology*; D006376:Helminths / Q000201:enzymology*