Synthetic inhibitors of DNA topoisomerase I and II.
A new type of synthetic inhibitor of DNA topoisomerase I and II was examined and several of these derivatives exhibited strong dual activity against these enzymes. This series of compounds showed high cytotoxic activities against cancer cells, but only a limited number of compounds showed any noticeable activity in an in vivo test against murine P388. Non-specific toxicity was observed in the in vivo tests.
Katayama
H
H
Niigata College of Pharmacy, Japan.
Kawada
Y
Y
Kaneko
K
K
Oshiyama
T
T
Takatsu
N
N
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004278:DNA, Superhelical / Q000737:chemistry / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D007211:Indoles / Q000138:chemical synthesis / Q000494:pharmacology; D007941:Leukemia P388 / Q000188:drug therapy / Q000201:enzymology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D019906:Nuclear Magnetic Resonance, Biomolecular; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors