Near-haploidy in a malignant sacrococcygeal teratoma.
Cytogenetic analysis of a malignant sacrococcygeal teratoma in an adult patient revealed near-haploid (77%), near-diploid (19%), and polyploid (4%) cells. The near-haploid cells had a karyotype of 25,XX,der(5)t(5;7)(p15;p13),+7,der(9)t(6;9)(p21;q34),r(17)(p13q25) . In the near-diploid and polyploid cells identical copies of the structural chromosomal changes were found. Although some of the anomalies observed appear unique to this case, a common breakpoint in chromosome 6 was previously reported as specific in a subgroup of extragonadal germ cell tumors of adults.
Noguera
R
R
Department of Pathology, Medical School, University of Valencia, Spain.
Navarro
S
S
Carda
C
C
Peydró-Olaya
A
A
Llombart-Bosch
A
A
D000368:Aged; D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5; D002896:Chromosomes, Human, Pair 6; D002897:Chromosomes, Human, Pair 7; D002899:Chromosomes, Human, Pair 9; D003050:Coccyx; D004171:Diploidy; D017809:Fatal Outcome; D005260:Female; D006238:Haploidy; D006801:Humans; D007621:Karyotyping; D011003:Ploidies; D011123:Polyploidy; D012447:Sacrum; D013125:Spinal Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D013724:Teratoma / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D014057:Tomography, X-Ray Computed; D014178:Translocation, Genetic