title: Effect of methotrexate on tubal epithelium. A report of three cases.
abstract: BACKGROUND
  Tubal effects of methotrexate injections have been poorly reported.
  
  
  METHODS
  Three fallopian tubes were examined with light microscopy 9-13 months after tubal methotrexate injection (one case) and intramuscular methotrexate injection (two cases) given for the treatment of unruptured ectopic pregnancies. No evidence of tubal damage was found.
  
  
  CONCLUSIONS
  These three cases confirm previous experimental and clinical data showing the absence of a direct adverse effect of methotrexate on the fallopian tubes in the treatment of ectopic pregnancy.
authors.affiliation: Gynecologic and Obstetric Service, Boucicaut Hospital, Paris, France. fabrice.lecuru@bcc.ap-hop-paris.fr
authors.forename: F
authors.initials: F
authors.lastname: Lécuru
authors.forename: F
authors.initials: F
authors.lastname: Robin
authors.forename: R
authors.initials: R
authors.lastname: Taurelle
authors.forename: J P
authors.initials: JP
authors.lastname: Bernard
authors.forename: F
authors.initials: F
authors.lastname: Vildé
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000328:Adult; D004848:Epithelium / Q000187:drug effects; D005187:Fallopian Tubes / Q000187:drug effects* / Q000473:pathology; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D010535:Laparoscopy; D008727:Methotrexate / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011247:Pregnancy; D011274:Pregnancy, Tubal / Q000188:drug therapy*