Genetic epidemiology of prostate cancer.
A family history of prostate cancer is a consistent risk factor for prostate cancer, and can also be used to predict the presence of prostate cancer among asymptomatic men who undergo PSA screening. Approximately 5% of cases of prostate cancer have a familial component. The genetic epidemiology of prostate cancer is complex, and genes on chromosome 1 and X chromosome contribute to familial aggregation. Neither of these prostate cancer susceptibility genes have been identified, but are the subject of an active search. Hereditary prostate cancer resembles non-hereditary cancer in terms of age of onset, pathologic appearance and grade.
Narod
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Department of Medicine, Women's College Hospital, Toronto, Ont., Canada. narod@ftn.net
D017668:Age of Onset; D016022:Case-Control Studies; D015331:Cohort Studies; D004200:Diseases in Twins / Q000235:genetics; D005006:Ethnicity; D005190:Family; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000032:analysis; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D012306:Risk; D018433:Twin Studies as Topic