title: [Outline of tumor invasion and metastasis].
abstract: Analysis of cancer genes and studies of cell growth, apoptosis and immortalization have shed light on how normal cells transform into malignant cancer cells. In addition, our knowledge of the molecular mechanisms by which cancer cells invade and traverse tissues and form distant metastases has been improved greatly. Several new therapeutic methods have been developed based on these new findings, and they are expected to provide patients with better choices.
authors.affiliation: Dept. of Cancer Cell Research, Institute of Medical Science, University of Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Seiki
mesh_terms: D017209:Apoptosis; D002455:Cell Division; D002471:Cell Transformation, Neoplastic; D006801:Humans; D009361:Neoplasm Invasiveness / Q000235:genetics; D009362:Neoplasm Metastasis / Q000235:genetics; D009369:Neoplasms / Q000235:genetics / Q000473:pathology*