title: Effect of immune priming on Borna disease.
abstract: Borna disease virus (BDV) is a neurotropic virus with a broad host and geographic range. Lewis rats were immunized against BDV with a recombinant vaccinia virus expressing the BDV nucleoprotein and were later infected with BDV to evaluate protection against Borna disease (BD). Relative to animals that were not immunized, immunized animals had a decreased viral burden after challenge with infectious virus, more marked inflammation, and aggravated clinical disease. These data suggest that a more robust immune response in Borna disease can reduce viral load at the expense of increased morbidity.
authors.affiliation: Department of Neurology, University of California, Irvine, California 92697-4292, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Lewis
authors.forename: J L
authors.initials: JL
authors.lastname: Whitton
authors.forename: C G
authors.initials: CG
authors.lastname: Hatalski
authors.forename: H
authors.initials: H
authors.lastname: Weissenböck
authors.forename: W I
authors.initials: WI
authors.lastname: Lipkin
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D001890:Borna Disease / Q000276:immunology*; D006367:HeLa Cells; D006801:Humans; D007114:Immunization; D008297:Male; D009698:Nucleoproteins / Q000276:immunology; D012367:RNA, Viral / Q000032:analysis; D051381:Rats; D011917:Rats, Inbred Lew; D014765:Viral Vaccines / Q000276:immunology*