title: Surface modification of polyurethane heart valves: effects on fatigue life and calcification.
abstract: Polyurethane heart valves can be functionally durable with minimal calcification, in vitro. In vivo, these characteristics will depend on the resistance of the polyurethane to thrombogenesis and biodegradation. Surface modification may improve the polyurethane in these respects, but may adversely affect calcification and durability. This study investigates the effects of surface modifications of two polyurethane heart valves (PEU and PEUE) on their in vitro fatigue and calcification behaviour. Modifications included heparin, taurine, 3-aminopropyltriethoxysilane and polyethylene oxide (PEO). Neither hydrodynamic function nor leaflet thickness distribution was significantly altered by surface modification. PEO-modification was detrimental to valve fatigue durability and calcification. Heparin, taurine or aminosilane modifications of PEU valves increased durability. Aminosilane modification of PEUE valves increased durability compared with PEO modification. Appropriate surface modification may be useful to improve blood compatibility of implantable polyurethanes, and may also be advantageous as regards fatigue durability of flexing materials in longterm applications.
authors.affiliation: University Department of Cardiac Surgery, Glasgow Royal Infirmary University NHS Trust, Scotland - UK.
authors.forename: G M
authors.initials: GM
authors.lastname: Bernacca
authors.forename: D J
authors.initials: DJ
authors.lastname: Wheatley
mesh_terms: D000704:Analysis of Variance; D001672:Biocompatible Materials / Q000737:chemistry*; D002114:Calcinosis / Q000209:etiology; D006350:Heart Valve Prosthesis; D006801:Humans; D008422:Materials Testing; D011140:Polyurethanes / Q000737:chemistry*; D011475:Prosthesis Failure; D013499:Surface Properties