Influence of renal failure on intestinal clearance of ciprofloxacin in rats.
Following intravenous doses, ciprofloxacin pharmacokinetics in control and nephrectomized rats were studied. There were no differences between control and nephrectomized rats for area under the concentration-time curve in plasma or biliary clearance. The intestinal clearance of ciprofloxacin was increased in nephrectomized rats. Intestinal elimination seems to compensate partially for the decrease in urinary excretion of ciprofloxacin in nephrectomized rats.
Service de Pharmacie Clinique et des Biomatériaux, G. H. Bichat-C. Bernard, Paris, France.
S
S
Dautrey
L
L
Rabbaa
D
D
Laouari
B
B
Lacour
C
C
Carbon
R
R
Farinotti
D000818:Animals; D000890:Anti-Infective Agents / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001646:Bile / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D002939:Ciprofloxacin / Q000493:pharmacokinetics*; D003404:Creatinine / Q000097:blood; D007413:Intestinal Mucosa / Q000378:metabolism*; D008297:Male; D009392:Nephrectomy; D010477:Perfusion; D051381:Rats; D017207:Rats, Sprague-Dawley; D051437:Renal Insufficiency / Q000378:metabolism*
D000890:Anti-Infective Agents; D002939:Ciprofloxacin; D003404:Creatinine