Antidepressant effect of an ethanolic extract of the leaves of Cissampelos sympodialis in rats and mice.
An ethanolic extract of the leaves of Cissampelos sympodialis Eichl. (Menispermaceae) was found to potentiate the toxicity of pentylenetetrazol in mice. Similar to imipramine, the extract also reduced the immobility period in the forced swimming test in mice and reversed the degree of ptosis and catalepsy induced by reserpine in rats. These results suggest that the extract possesses antidepressant activity and the reported phosphodiesterase inhibitory activity of the plant may account for the observed antidepressant effect.
Almeida
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Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, João Pessoa, Brazil.
Navarro
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de Assis
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de Medeiros
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Thomas
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D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D001763:Blepharoptosis / Q000139:chemically induced; D002375:Catalepsy / Q000139:chemically induced; D004357:Drug Synergism; D000431:Ethanol; D007099:Imipramine / Q000494:pharmacology; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole / Q000633:toxicity; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012110:Reserpine / Q000633:toxicity; D012640:Seizures / Q000139:chemically induced; D012997:Solvents
D000928:Antidepressive Agents; D000929:Antidepressive Agents, Tricyclic; D010936:Plant Extracts; D012997:Solvents; D000431:Ethanol; D012110:Reserpine; D007099:Imipramine; D010433:Pentylenetetrazole