Total serum bile acid concentrations in dairy cows with fatty liver and liver failure.
In forty-five Holstein Frisian dairy cows (1-6 weeks post partum; mean age: 5.1 +/- 1.2 years) the serum total bile acid concentrations (SBA) were measured enzymatically. In all cows a left sided abomasal displacement was corrected surgically by right side laparotomy and omentopexy three days before investigation. The liver fat content was determined in all cows histologically. Liver failure was assumed if typical clinical signs (ataxia, general depression, recumbency or coma), an increased venous plasma ammonia level (> 35 mumol/l) and a decreased plasma amino acid index (< 4.0) were found. Cows without liver failure (N = 29) were grouped according to the liver fat content as cows with mild (N = 5), moderate (N = 19) or severe hepatosteatosis (N = 5). Histological examination of liver biopsies in cows with liver failure (N = 16) revealed in twelve cases a severe fatty liver and in four cases a hydropic degeneration of the liver tissue. Although in cows without liver failure mean SBA concentrations were higher in the group with moderate (47.3 +/- 30.9 mumol/l) or severe fatty liver (32.9 +/- 21.7 mumol/l) than in that with mild lipidosis (18.0 (16.8 mumol/l), differences were not significant. The mean SBA concentration in cows with liver failure (70.5 +/- 49.5 mumol/l) was only significantly (p < 0.05) increased compared to cows with uncomplicated mild hepatic lipidosis. In conclusion, the determination of SBA concentrations is of little value in the recognition of fatty liver or even liver failure due to the considerable variance of SBA concentrations in dairy cows.
Rehage
J
J
Clinic for Diseases of Cattle, Hanover School of Veterinary Medicine, Germany.
Qualmann
K
K
Meier
C
C
Stockhofe-Zurwieden
N
N
Hoeltershinken
M
M
Pohlenz
J
J
D000018:Abomasum / Q000002:abnormalities / Q000601:surgery; D000818:Animals; D001647:Bile Acids and Salts / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002417:Cattle / Q000002:abnormalities; D002418:Cattle Diseases / Q000097:blood* / Q000503:physiopathology; D005234:Fatty Liver / Q000097:blood / Q000503:physiopathology / Q000662:veterinary*; D017093:Liver Failure / Q000097:blood / Q000503:physiopathology / Q000662:veterinary*
D001647:Bile Acids and Salts; D015415:Biomarkers