Developmental regulation of immune system gene rearrangement.
Rearrangement of antigen receptors in the immune system is mediated through the action of complex enhancers which function in both a developmentally stage-specific and a cell-type-specific manner to demethylate DNA, open chromatin structure and tether the recombination machinery to one preferred allele at each locus.
Department of Cellular Biochemistry, The Hebrew University Hadassah Medical School, Jerusalem, Israel. cedar@md2.huji.ac.il.
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D000818:Animals; D018507:Gene Expression Regulation, Developmental; D015321:Gene Rearrangement / Q000235:genetics*; D005803:Genes, Immunoglobulin / Q000235:genetics*; D006801:Humans; D007107:Immune System / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*