Simultaneous lactate editing and observation of other metabolites using a stimulated-echo-enhanced double-quantum filter.
Conventional double-quantum editing techniques recover only one metabolite at a time, and are thus inefficient for monitoring metabolic changes involving several metabolites. In this paper, a stimulated-echo-enhanced selective double-quantum coherence transfer (STE-SelDQC) sequence is described, which allows simultaneous observation of lactate and other metabolites in a single scan while leaving fat and water signals suppressed. A frequency selective double-quantum filter designed for lactate editing suppresses fat and water resonances and a stimulated-echo window of adjustable frequency and bandwidth is incorporated into the double-quantum filter for simultaneous observation of other metabolites. The performance of the sequence is demonstrated in phantoms and rat brain tissue.
Department of Chemistry, The University of Manitoba, Winnipeg, Manitoba, R3E 0W3, Canada.
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D000818:Animals; D001834:Body Water / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D017352:Echo-Planar Imaging / Q000379:methods*; D019344:Lactic Acid / Q000378:metabolism*; D008962:Models, Theoretical; D019047:Phantoms, Imaging; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D019344:Lactic Acid; D005680:gamma-Aminobutyric Acid; D003401:Creatine; D002794:Choline