Telomerase-independent modulation of telomere lengths in mammalian chromatids.
The paper discusses modulation of telomere length by mechanisms that do not require telomerase. Although ultimately dependent upon the cell's mitotic potential, these mechanisms do not sufficiently discriminate between normal and malignant cells.
Matioli
G T
GT
USC Medical School, Los Angeles, CA 90033, USA.
D000818:Animals; D001482:Base Composition; D002842:Chromatids / Q000737:chemistry / Q000235:genetics / Q000648:ultrastructure; D004247:DNA / Q000235:genetics; D006801:Humans; D008322:Mammals; D008957:Models, Genetic; D009690:Nucleic Acid Conformation; D012854:Sister Chromatid Exchange; D019098:Telomerase / Q000378:metabolism; D016615:Telomere / Q000737:chemistry / Q000235:genetics* / Q000648:ultrastructure*
D004247:DNA; D019098:Telomerase