Protective effect of dietary tomato against endothelial dysfunction in hypercholesterolemic mice.
The effects of dietary ingestion of tomato were studied in mice that had been made hypercholesterolemic by feeding atherogenic diets. Mice which had been fed on the atherogenic diet without tomato for 4 months had significantly increased plasma lipid peroxide, and the vaso-relaxing activity in the aorta induced by acetylcholine (ACh) was harmed when compared with mice fed on a common commercial diet. On the other hand, mice which had been fed on the atherogenic diet containing 20% (w/w) lyophilized powder of tomato showed less increase in the plasma lipid peroxide level, and ACh-induced vaso-relaxation was maintained at the same level as that in normal mice. These results indicate that tomato has a preventive effect on atherosclerosis by protecting plasma lipids from oxidation.
Research Institute, Kagome Co. Ltd., Tochigi, Japan. Hiroyuki_Suganuma@kagome.co.jp
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D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001013:Aorta, Thoracic / Q000187:drug effects / Q000503:physiopathology; D001161:Arteriosclerosis / Q000517:prevention & control*; D002338:Carotenoids / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood; D004032:Diet; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology*; D006937:Hypercholesterolemia / Q000150:complications / Q000178:diet therapy* / Q000503:physiopathology*; D066298:In Vitro Techniques; D008054:Lipid Peroxides / Q000097:blood; D000077276:Lycopene; D018551:Solanum lycopersicum; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009638:Norepinephrine / Q000494:pharmacology; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014661:Vasoconstriction / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects
D000975:Antioxidants; D008054:Lipid Peroxides; D017392:Thiobarbituric Acid Reactive Substances; D002338:Carotenoids; D002784:Cholesterol; D000109:Acetylcholine; D000077276:Lycopene; D009638:Norepinephrine