NMR screening in drug discovery.
NMR methods in drug discovery have traditionally been used to obtain structural information for drug targets or target-ligand complexes. Recently, it has been shown that NMR may be used as an alternative approach for identification of ligands that bind to protein drug targets, shifting the emphasis of many NMR laboratories towards screening and design of potential drug molecules, rather than structural characterization.
Vertex Pharmaceuticals Incorporated 130 Waverly Street Cambridge MA 02139-4242 USA. moore@vpharm.com
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Moore
D001709:Biotechnology / Q000379:methods*; D015195:Drug Design; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D010330:Patents as Topic; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D013329:Structure-Activity Relationship
D008024:Ligands; D004364:Pharmaceutical Preparations; D011506:Proteins