Primary biliary cirrhosis associated with membranous glomerulonephritis.
A 33-year-old woman was admitted to our department for evaluation of liver dysfunction and proteinuria. A liver biopsy specimen showed ductular proliferation and moderate portal fibrosis indicating stage II primary biliary cirrhosis. A renal biopsy specimen showed mild to moderate mesangial cell proliferation without crescent formation or interstitial nephritis. Immunofluorescent staining revealed deposition of immunoglobulin G (IgG), third component of complement (C3), and Clq on glomerular basement membranes. The findings indicated stage I membranous glomerulonephritis. Administration of ursodesoxycholic acid together with prednisolone, azathioprine, and dipyridamole decreased proteinuria and improved cholestatic liver dysfunction.
First Department of Internal Medicine, Akita University School of Medicine.
T
T
Goto
M
M
Komatsu
T
T
Fujii
S
S
Ohshima
K
K
Nakane
K
K
Yoneyama
T
T
Shibuya
X W
XW
Meng
O
O
Masamune
H
H
Imai
D000328:Adult; D001379:Azathioprine / Q000627:therapeutic use; D001706:Biopsy; D002756:Cholagogues and Choleretics / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004176:Dipyridamole / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D015433:Glomerulonephritis, Membranous / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007678:Kidney Glomerulus / Q000378:metabolism / Q000473:pathology; D008105:Liver Cirrhosis, Biliary / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use
D002756:Cholagogues and Choleretics; D005938:Glucocorticoids; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents; D010726:Phosphodiesterase Inhibitors; D004176:Dipyridamole; D014580:Ursodeoxycholic Acid; D011239:Prednisolone; D001379:Azathioprine