Nefazodone overdose: a case report.
Nefazodone (Serzone) is one of the newer medications developed to treat major depression. It is a phenylpiperazine derivative that inhibits the reuptake of both norepinephrine and serotonin and antagonizes the 5HT2 and alpha-one adrenergic receptors. It is well tolerated by patients, and is felt to have a much wider margin of safety than older antidepressants. We report the case of a woman who attempted suicide by ingesting a large amount of nefazodone and a smaller amount of verapamil. We review the literature regarding nefazodone side effects and previous cases of overdose, discuss the clinical complications of such an overdose and discuss treatment recommendation.
Catalano
G
G
Department of Psychiatry, University of South Florida College of Medicine, Tampa, USA.
Catalano
M C
MC
Tumarkin
N B
NB
D000328:Adult; D000368:Aged; D018687:Antidepressive Agents, Second-Generation / Q000506:poisoning*; D003865:Major Depressive Disorder / Q000188:drug therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D010879:Piperazines; D014230:Triazoles / Q000506:poisoning*
D018687:Antidepressive Agents, Second-Generation; D010879:Piperazines; D014230:Triazoles; C051752:nefazodone