[The mutagenic and antimutagenic effects of immunomodulators].
In animal experiments (albino rats), stimulating and suppressive effects were studied of immunomodulating agents on the processes of chemical mutagenesis. Combination of different immunodepressants hardly ever intensifies cyclophosphamide-induced chromosomal rearrangement in rat bone marrow cells, with heparin exerting an antimutagenic effect, while corticosterone, when being administered at an augmented dose, appeared to enhance cyclophosphamide's mutagenic action. One-stage administration of immunostimulants and cyclophosphamide tended to weaken antimutagenic defence of cell genetic apparatus.
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Sergeeva
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001854:Bone Marrow Cells / Q000187:drug effects; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D007166:Immunosuppressive Agents / Q000494:pharmacology; D007962:Leukocytes / Q000187:drug effects / Q000201:enzymology; D009153:Mutagens / Q000494:pharmacology*; D051381:Rats
D000276:Adjuvants, Immunologic; D016587:Antimutagenic Agents; D007166:Immunosuppressive Agents; D009153:Mutagens