The biochemistry of Dupuytren's disease.
The molecular biochemical aspects of Dupuytren's disease have been studied for decades. This article summarizes biochemical influences on myofibroblast contractility, endogenous and exogenous chemical regulation, the influence of growth factors, and the biochemistry of collagen. A clear insight into the biochemistry of Dupuytren's disease may provide a foundation for future clinical interventions.
Department of Orthopaedics, Health Science Center, State University of New York at Stony Brook, USA.
M A
MA
Badalamente
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LC
Hurst
D003094:Collagen / Q000378:metabolism; D004387:Dupuytren Contracture / Q000378:metabolism* / Q000473:pathology; D005205:Fascia / Q000166:cytology / Q000378:metabolism; D005342:Fibrinolysis / Q000502:physiology; D005347:Fibroblasts / Q000502:physiology / Q000648:ultrastructure; D006801:Humans; D009119:Muscle Contraction / Q000502:physiology; D010982:Platelet-Derived Growth Factor / Q000378:metabolism
D010982:Platelet-Derived Growth Factor; D003094:Collagen