Hydroxyapatite-coated orthopaedic screws as infection resistant materials: in vitro study.
The authors evaluated in vitro the adherence of a Staphylococcus epidermidis strain to hydroxyapatite-coated stainless-steel screws-used in orthopaedic surgery for external fracture fixation-in comparison with the adherence to uncoated screws. Evaluations were also performed on analogous groups of screws immersed for 72 and 168 h in a solution at 37 degrees C, in order to simulate the interstitial fluid in a simplified way. Adherence values on coated prostheses resulted significantly lower compared with those observed on metal prostheses, both in basal conditions and after immersion in saline solution. Moreover, both on coated and on uncoated screws a significant reduction in bacterial adherence was noted related to the duration of the prosthesis permanence in saline solution.
Arciola
C R
CR
Laboratory for Biocompatibility Research on Implant Materials and 9th Orthopaedic Division of Instituto Ortopedico Rizzoli, Bologna, Italy.
Montanaro
L
L
Moroni
A
A
Giordano
M
M
Pizzoferrato
A
A
Donati
M E
ME
D001422:Bacterial Adhesion; D001863:Bone Screws; D002118:Calcium; D020099:Coated Materials, Biocompatible; D017886:Durapatite; D013193:Stainless Steel; D013203:Staphylococcal Infections / Q000517:prevention & control*; D013212:Staphylococcus epidermidis; D013997:Time Factors
D020099:Coated Materials, Biocompatible; D013193:Stainless Steel; D017886:Durapatite; D002118:Calcium