Correlation of activity regulation and substrate recognition of the ADP-ribosyltransferase that regulates nitrogenase activity in Rhodospirillum rubrum.
In Rhodospirillum rubrum, nitrogenase activity is regulated posttranslationally through the ADP-ribosylation of dinitrogenase reductase by dinitrogenase reductase ADP-ribosyltransferase (DRAT). Several DRAT variants that are altered both in the posttranslational regulation of DRAT activity and in the ability to recognize variants of dinitrogenase reductase have been found. This correlation suggests that these two properties are biochemically connected.
Department of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
K
K
Kim
Y
Y
Zhang
G P
GP
Roberts
D036002:ADP Ribose Transferases / Q000235:genetics* / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D015971:Gene Expression Regulation, Enzymologic; D014644:Genetic Variation; D005838:Genotype; D007700:Kinetics; D009591:Nitrogenase / Q000235:genetics / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D012247:Rhodospirillum rubrum / Q000201:enzymology* / Q000235:genetics; D013379:Substrate Specificity
D009591:Nitrogenase; D036002:ADP Ribose Transferases; C057637:dinitrogenase reductase ADP-ribosyltransferase