No association between a polymorphic CAG repeat in the human potassium channel gene hKCa3 and bipolar disorder.
A recent case-control study suggested that modest enlargements of a CAG repeat in the hKCa3 potassium channel may be associated with bipolar disorder. We tried to replicate this result in a UK Caucasian sample of 203 DSM-IV bipolar I disorder patients and 206 controls group-matched for age and sex. Using the same model of analysis as the earlier study, bipolar probands did not have a higher frequency of alleles with greater than 19 repeats than controls (chi2 = 1.44, 1 df, P = 0.23). Similarly, comparison of the distributions of repeat sizes between probands and controls did not approach statistical significance (Mann-Whitney U test, P = 0.35). We conclude that our data provide no support for the hypothesis that variation at the hKCa3 gene contributes to susceptibility to bipolar disorder.
Guy
C A
CA
Division of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK.
Bowen
T
T
Williams
N
N
Jones
I R
IR
McCandless
F
F
McGuffin
P
P
Owen
M J
MJ
Craddock
N
N
O'Donovan
M C
MC
D000328:Adult; D000483:Alleles; D001714:Bipolar Disorder / Q000209:etiology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D015221:Potassium Channels / Q000235:genetics*; D024681:Potassium Channels, Calcium-Activated; D051640:Small-Conductance Calcium-Activated Potassium Channels; D018911:Trinucleotide Repeats / Q000235:genetics*
C406328:KCNN3 protein, human; D015221:Potassium Channels; D024681:Potassium Channels, Calcium-Activated; D051640:Small-Conductance Calcium-Activated Potassium Channels