A new picornavirus isolated from bank voles (Clethrionomys glareolus).
A previously unknown picornavirus was isolated from bank voles (Clethrionomys glareolus). Electron microscopy images and sequence data of the prototype isolate, named Ljungan virus, showed that it is a picornavirus. The amino acid sequences of predicted Ljungan virus capsid proteins VP2 and VP3 were closely related to the human pathogen echovirus 22 (approximately 70% similarity). A partial 5' noncoding region sequence of Ljungan virus showed the highest degree of relatedness to cardioviruses. Two additional isolates were serologically and molecularly related to the prototype.
Niklasson
B
B
Swedish Institute for Infectious Disease Control, Solna, S-171 82, Sweden. bo.niklasson@smi.ki.se
Kinnunen
L
L
Hörnfeldt
B
B
Hörling
J
J
Benemar
C
C
Hedlund
K O
KO
Matskova
L
L
Hyypiä
T
T
Winberg
G
G
D000595:Amino Acid Sequence; D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D003411:Arvicolinae / Q000821:virology*; D001483:Base Sequence; D002213:Capsid / Q000235:genetics; D036022:Capsid Proteins; D017943:Cardiovirus / Q000276:immunology; D003429:Cross Reactions; D003588:Cytopathogenic Effect, Viral; D004279:DNA, Viral; D029822:Enterovirus B, Human / Q000276:immunology; D006801:Humans; D008969:Molecular Sequence Data; D010849:Picornaviridae / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification / Q000648:ultrastructure; D017386:Sequence Homology, Amino Acid; D014771:Virion / Q000648:ultrastructure
D000956:Antigens, Viral; D036022:Capsid Proteins; D004279:DNA, Viral; C442554:VP2 protein, Echovirus