A multiple drug interaction study of stavudine with agents for opportunistic infections in human immunodeficiency virus-infected patients.
The effects of multiple opportunistic infection medications on stavudine pharmacokinetics were evaluated. Ten patients with CD4 counts of less than 200 cells/mm3 received stavudine (40 mg twice daily) in combination with one to three other drugs used to treat opportunistic infections. Serial blood samples for stavudine concentrations were collected after 1 week of therapy on each regimen and assayed for stavudine by using a validated high-pressure liquid chromatography method. Although the maximum concentration of drug in serum was significantly decreased when the drug was given in combination with three opportunistic infection medications, the area under the concentration-time curve did not significantly differ across various treatment regimens. Stavudine exposure was not significantly altered by multiple concomitant medications. Side effects were minor throughout the 3-month study period. The tolerability of stavudine, combined with its lack of drug interactions, makes it an attractive agent for use as part of a combination regimen.
Department of Pharmacy, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-1196, USA. spisc@nih.gov
S C
SC
Piscitelli
G
G
Kelly
R E
RE
Walker
J
J
Kovacs
J
J
Falloon
R T
RT
Davey
S
S
Raje
H
H
Masur
M A
MA
Polis
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy*; D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D019540:Area Under Curve; D004347:Drug Interactions; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008297:Male; D010349:Patient Compliance; D018119:Stavudine / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use
D019380:Anti-HIV Agents; D000890:Anti-Infective Agents; D018119:Stavudine