Histone H1o ribosomal RNA synthesis and cell differentiation.
It is proposed that histone H1o prevents binding of the rRNA transcription factor UBF to regulatory sequences of the rRNA gene. This has a role in reducing rRNA synthesis and inhibiting cell proliferation. This affords the opportunity for other mechanisms to promote cell differentiation.
Flickinger
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Department of Biological Sciences, State University of New York, Buffalo, NY 14260, USA.
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D002468:Cell Physiological Phenomena; D004268:DNA-Binding Proteins / Q000378:metabolism; D016179:Granulocyte Colony-Stimulating Factor / Q000378:metabolism; D006657:Histones / Q000378:metabolism*; D008954:Models, Biological; D035463:Pol1 Transcription Initiation Complex Proteins; D014176:Protein Biosynthesis; D012335:RNA, Ribosomal / Q000096:biosynthesis*; D014157:Transcription Factors / Q000378:metabolism; D014212:Tretinoin / Q000378:metabolism
D004268:DNA-Binding Proteins; D006657:Histones; D035463:Pol1 Transcription Initiation Complex Proteins; D012335:RNA, Ribosomal; D014157:Transcription Factors; C063844:transcription factor UBF; D016179:Granulocyte Colony-Stimulating Factor; D014212:Tretinoin