The fundamentals of protein folding: bringing together theory and experiment.
Experimental and theoretical studies together are providing insights into the mechanism by which proteins fold. Our present knowledge of the essential aspects of the folding reaction is outlined and some approaches, both theoretical and experimental, that are being developed to obtain a more detailed understanding of this complex process are described.
Dobson
C M
CM
Oxford Centre for Molecular Sciences, New Chemistry Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QT, UK. chris.dobson@chem.ox.ac.uk
Karplus
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M
D008958:Models, Molecular; D017510:Protein Folding; D013499:Surface Properties; D013816:Thermodynamics