Selective expression of purinoceptor cP2Y1 suggests a role for nucleotide signalling in development of the chick embryo.
Responses to extracellular nucleotides (e.g., ATP, ADP, etc.) have been demonstrated in a number of embryonic cell types suggesting they may be important signalling molecules during embryonic development. Here the authors describe for the first time the expression of a G-protein-coupled receptor for extracellular ATP, chick P2Y1 (cP2Y1), during embryonic development of the chick. During the first 10 days of embryonic development, cP2Y1 is expressed in a developmentally regulated manner in the limb buds, mesonephros, brain, somites, and facial primordia, suggesting that this receptor may have a role in the development of each of these systems.
Department of Anatomy and Developmental Biology, University College London, England. ucgampm@ucl.ac.uk
M P
MP
Meyer
J D
JD
Clarke
K
K
Patel
A
A
Townsend-Nicholson
G
G
Burnstock
D000818:Animals; D015152:Blotting, Northern; D001934:Branchial Region / Q000033:anatomy & histology; D002490:Central Nervous System / Q000033:anatomy & histology; D002642:Chick Embryo / Q000033:anatomy & histology / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D017403:In Situ Hybridization; D018878:Limb Buds / Q000033:anatomy & histology; D008650:Mesonephros / Q000033:anatomy & histology; D011983:Receptors, Purinergic / Q000235:genetics* / Q000502:physiology*; D018048:Receptors, Purinergic P2 / Q000235:genetics*; D058472:Receptors, Purinergic P2Y1; D019170:Somites / Q000502:physiology; D013997:Time Factors; D014018:Tissue Distribution
D011983:Receptors, Purinergic; D018048:Receptors, Purinergic P2; D058472:Receptors, Purinergic P2Y1