[Treatment of CMV retinitis with intravitreal foscarnet].
OBJECTIVE
To assess the tolerability and efficacy of intravitreal injections of foscarnet in cytomegalovirus (CMV) retinitis in acquired immunodeficiency syndrome (AIDS).


METHODS
Patients with CMV retinitis resistant and/or intolerant to intravenous foscarnet and ganciclovir and resistant to intravitreal ganciclovir were included. The induction therapy consisted of intravitreal injections of 2,400 micrograms of foscarnet twice a week. The assessment was performed by clinical examination and photographies of the fundus.


RESULTS
Three patients (four eyes) have been included. Three eyes were administered seven and one eye eight intravitreal injections. The tolerability was good, but the efficacy was mere: the retinal lesions became less edematous, but they still extended.


CONCLUSIONS
In these four eyes with CMV retinitis resistant to intravitreal ganciclovir, intravitreal injections of foscarnet were well tolerated but did not stop the progression of the retinitis.
Cochereau
I
I
Service d'Ophtalmologie, Hôpital Bichat-Claude Bernard, Paris.
Belayachi
N
N
Diraison
C
C
Matheron
S
S
Bouyer
I
I
Hoang-Xuan
T
T
Saimot
A G
AG
Coulaud
J P
JP
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy* / Q000473:pathology; D000998:Antiviral Agents / Q000008:administration & dosage*; D017726:Cytomegalovirus Retinitis / Q000188:drug therapy* / Q000473:pathology; D018450:Disease Progression; D004334:Drug Administration Schedule; D016903:Drug Monitoring; D005260:Female; D017245:Foscarnet / Q000008:administration & dosage*; D006801:Humans; D007267:Injections / Q000379:methods*; D008297:Male; D016896:Treatment Outcome; D014822:Vitreous Body
D000998:Antiviral Agents; D017245:Foscarnet