Regression of cholesterol induced venous plaques after cholesterol withdrawal in rabbits.
Rabbits receiving a dietary cholesterol supplement of 0.5% develop atheromatous plaques in the systemic arteries, the pulmonary artery, the pulmonary veins and the venous cavities of the plexus pampiniformis in the funiculus spermaticus. Six months after the withdrawal of the cholesterol supplement the arterial lesions are still present, and show a fibrous transformation. This study is the first report of the total regression of the lesions in the particular venous localizations of the lungs and the plexus pampiniformis. The level of intraluminal pressure is discussed as the possible mechanism responsible for the diverging vascular reactivity.
Department of Medicine, University of Antwerp - UIA, Wilrijk, Belgium.
N
N
Buyssens
M M
MM
Kockx
H
H
Bult
R
R
Van Den Bossche
L T
LT
Herman
A G
AG
Herman
D000199:Actins / Q000378:metabolism; D000818:Animals; D001158:Arteries / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D001161:Arteriosclerosis / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D002791:Cholesterol, Dietary / Q000009:adverse effects*; D004036:Diet, Atherogenic; D007150:Immunohistochemistry; D008055:Lipids / Q000097:blood; D008168:Lung / Q000098:blood supply / Q000473:pathology; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000378:metabolism / Q000473:pathology; D011817:Rabbits; D012075:Remission, Spontaneous; D013085:Spermatic Cord / Q000098:blood supply / Q000473:pathology; D013737:Testis / Q000098:blood supply / Q000473:pathology; D014680:Veins / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology
D000199:Actins; D002791:Cholesterol, Dietary; D008055:Lipids