Does the addition of pindolol accelerate or enhance the response to selective serotonin reuptake inhibitor antidepressants?
Although in the last few years new antidepressants have become available in the United States, responses in many patients differ, from none, to partial, to delayed therapeutic response to the agents. If the antidepressant properties of these drugs could be enhanced or accelerated, it might be possible to improve patient functioning and quality of life. Pindolol, a serotonin 1A autoreceptor antagonist, accelerates and augments the therapeutic effects of antidepressants, especially selective serotonin reuptake inhibitors.
Department of Psychiatry, San Francisco General Hospital, California 94110, USA.
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Puzantian
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Kawase
D000928:Antidepressive Agents / Q000494:pharmacology*; D004357:Drug Synergism; D006801:Humans; D010865:Pilot Projects; D010869:Pindolol / Q000494:pharmacology*; D016032:Randomized Controlled Trials as Topic; D011985:Receptors, Serotonin / Q000502:physiology; D044263:Receptors, Serotonin, 5-HT1; D012702:Serotonin Antagonists / Q000494:pharmacology*; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*
D000928:Antidepressive Agents; D010869:Pindolol; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D012702:Serotonin Antagonists; D017367:Selective Serotonin Reuptake Inhibitors