Systemic candidiasis with candida vasculitis due to Candida kruzei in a patient with acute myeloid leukaemia.
Candida kruzei-related systemic infections are increasing in frequency, particularly in patients receiving prophylaxis with antifungal triazoles. A Caucasian male with newly diagnosed acute myeloid leukaemia (AML M1) developed severe and persistent fever associated with a micropustular eruption scattered over the trunk and limbs during induction chemotherapy. Blood cultures grew Candida kruzei, and biopsies of the skin lesions revealed a candida vasculitis. He responded to high doses of liposomal amphotericin B and was discharged well from hospital.
Department Dermatology, Royal Marsden Hospital, Sutton, Surrey, UK.
R K
RK
Gregory
R L
RL
Powles
J G
JG
Treleaven
M L
ML
Smith
P S
PS
Mortimer
A
A
Wotherspoon
U
U
Riley
D000208:Acute Disease; D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D002177:Candidiasis / Q000188:drug therapy / Q000209:etiology*; D004337:Drug Carriers; D006801:Humans; D007951:Leukemia, Myeloid / Q000150:complications*; D008081:Liposomes; D008297:Male; D008875:Middle Aged; D014230:Triazoles / Q000627:therapeutic use; D014657:Vasculitis / Q000209:etiology / Q000378:metabolism
D000935:Antifungal Agents; D004337:Drug Carriers; D008081:Liposomes; D014230:Triazoles; D000666:Amphotericin B