N-ethylmaliemide (NEM)-stimulated passive potassium transport in camel erythrocytes: inhibitory effects of age, furosemide, sodium fluoride and okadaic acid.
The effects of age, and the inhibitory effects of furosemide, sodium fluoride, and okadaic acid on N-ethylmaliemide (NEM)-stimulated, ouabain-resistant potassium influx were investigated in camel erythrocytes. The NEM-stimulated influx which declined with the age of erythrocytes, was partially inhibited by 2 mmol/L furosemide, 20 mmol/L sodium fluoride, and completely inhibited by 150 nM okadaic acid. The effect of all chemical inhibitors was significant if added before the NEM pretreatment.
Department of Physiology & Biochemistry, Jordan University of Science and Technology, Irbid, Jordan.
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Gharaibeh
D000375:Aging; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002162:Camelus / Q000097:blood*; D002352:Carrier Proteins / Q000378:metabolism; D004905:Erythrocyte Aging; D004912:Erythrocytes / Q000378:metabolism*; D005033:Ethylmaleimide / Q000494:pharmacology*; D005260:Female; D005665:Furosemide / Q000494:pharmacology; D019319:Okadaic Acid / Q000494:pharmacology; D011188:Potassium / Q000097:blood*; D012969:Sodium Fluoride / Q000494:pharmacology; D027981:Symporters; D000096922:K Cl- Cotransporters
D002352:Carrier Proteins; D005033:Ethylmaleimide; D005665:Furosemide; D019319:Okadaic Acid; D011188:Potassium; D012969:Sodium Fluoride; D027981:Symporters; D000096922:K Cl- Cotransporters