Nefazodone overdose: a case report.
Nefazodone (Serzone) is one of the newer medications developed to treat major depression. It is a phenylpiperazine derivative that inhibits the reuptake of both norepinephrine and serotonin and antagonizes the 5HT2 and alpha-one adrenergic receptors. It is well tolerated by patients, and is felt to have a much wider margin of safety than older antidepressants. We report the case of a woman who attempted suicide by ingesting a large amount of nefazodone and a smaller amount of verapamil. We review the literature regarding nefazodone side effects and previous cases of overdose, discuss the clinical complications of such an overdose and discuss treatment recommendation.
Department of Psychiatry, University of South Florida College of Medicine, Tampa, USA.
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Catalano
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Catalano
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Tumarkin
D000328:Adult; D000368:Aged; D018687:Antidepressive Agents, Second-Generation / Q000506:poisoning*; D003865:Major Depressive Disorder / Q000188:drug therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D010879:Piperazines; D014230:Triazoles / Q000506:poisoning*
D018687:Antidepressive Agents, Second-Generation; D010879:Piperazines; D014230:Triazoles; C051752:nefazodone