Virulence gene regulation by peptides in staphylococci and other Gram-positive bacteria.
In staphylococci, autoinducing peptides activate agr. a global regulator of the expression of genes encoding virulence factors and other exoproteins. During the past year, there have been major advances in the structure-function analysis of these peptides and the regulation of a virulence factor by an autoinducing peptide in pneumococci has been demonstrated.
Skirball Institute of Biomolecular Medicine New York University School of Medicine 540 First Ave 2nd floor New York NY 10016 USA. novick@saturn.med.nyu.edu
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D000595:Amino Acid Sequence; D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism*; D004265:DNA Helicases / Q000494:pharmacology; D004268:DNA-Binding Proteins; D004195:Disease Models, Animal; D015964:Gene Expression Regulation, Bacterial; D051379:Mice; D009154:Mutation; D010456:Peptides, Cyclic; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction; D015534:Trans-Activators / Q000494:pharmacology
C414532:AgrD protein, Staphylococcus; D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D010456:Peptides, Cyclic; D015534:Trans-Activators; C110354:rap protein, bacteria; C045264:replication initiator protein; D004265:DNA Helicases