Rapid autologous marrow recovery and eradication of infectious mononucleosis despite severe immunosuppression following second transplantation for aplastic anemia.
A patient with aplastic anemia failed to respond to immunosuppressive therapy and first marrow transplantation (BMT). Recovery of autologous hematopoiesis was rapid following a second stem cell transplant with a non-myeloablative preparatory regimen. The autologous immune response to infectious mononucleosis (IM) 4 weeks post-transplant was normal despite recent and ongoing severe immunosuppression.
Rossbach
H C
HC
Division of Pediatric Hematology/Oncology and Bone Marrow Transplantation, All Children's Hospital, University of South Florida College of Medicine, St Petersburg, USA.
Hosler
K M
KM
Chamizo
W
W
Mueller
T
T
Grana
N H
NH
Lacson
A G
AG
Barbosa
J L
JL
D000741:Anemia, Aplastic / Q000628:therapy*; D016026:Bone Marrow Transplantation; D002648:Child; D018380:Hematopoietic Stem Cell Transplantation; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D007113:Immunity, Innate; D007165:Immunosuppression Therapy; D007244:Infectious Mononucleosis / Q000209:etiology / Q000276:immunology*; D008297:Male; D014182:Transplantation, Autologous