Rational recognition of nucleic acid sequences.
Recent progress in synthetic and computational chemistry has made it possible to develop certain novel drug candidates. Drug candidates for genetic diseases, such as cancer, may also be designed on the basis of structural information obtained using X-ray analysis and NMR, as well as evidence from biological techniques applied to natural products - DNA (or RNA) complexes and conjugates. The resulting designed drug candidates exhibit promising performance based on the recognition on nucleic acid sequences.
Department of Chemistry University of Alberta Edmonton Alberta T6G2G2 Canada.
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D000477:Alkylating Agents / Q000737:chemistry / Q000378:metabolism; D001665:Binding Sites; D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D015195:Drug Design; D008958:Models, Molecular; D015335:Molecular Probes / Q000737:chemistry* / Q000378:metabolism; D020135:Peptide Nucleic Acids / Q000737:chemistry / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000378:metabolism*; D014961:X-Ray Diffraction
D000477:Alkylating Agents; D015335:Molecular Probes; D020135:Peptide Nucleic Acids; D004364:Pharmaceutical Preparations; D004247:DNA