Effects of experimental osteoporosis on alveolar bone loss in rats.
A study was conducted to investigate the relationship between osteoporosis and alveolar bone loss. Alveolar bone loss was evaluated by radiographic and visual inspection of rats with experimental osteoporosis. Twenty 4-week-old female Sprague-Dawley rats were divided into the following groups: Group A-ovariectomized and given a standard solid diet; Group B-ovariectomized and given a calcium-deficient diet; Group C-sham-ovariectomized and given a standard solid diet; and Group D-sham-ovariectomized and given a calcium-deficient diet. After 4 weeks, the rat were euthanatized. The maxillae, mandibles, femurs, and tibias were removed carefully and fixed in 10% neutral buffered formalin. The bone mineral density of each bone and the alveolar bone loss were measured. The bone mineral densities of the maxillae, mandibles, femurs and tibias in Group C were significantly higher than those in Groups B and D, but not higher than those in Group A. However, there were no significant differences between any of the groups with regard to alveolar bone loss from the cemento-enamel junction to the molar bone crest. Therefore, it was concluded that osteoporosis itself may not be capable of causing periodontal destruction, and thus may not be a major factor in periodontal disease.
Department of Periodontology, Nihon University School of Dentistry, Tokyo, Japan.
Y
Y
Moriya
K
K
Ito
S
S
Murai
D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging* / Q000209:etiology; D000818:Animals; D015519:Bone Density; D002136:Calcium, Dietary / Q000008:administration & dosage; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging; D008334:Mandible / Q000000981:diagnostic imaging; D008336:Mandibular Diseases / Q000000981:diagnostic imaging* / Q000209:etiology; D008437:Maxilla / Q000000981:diagnostic imaging; D008439:Maxillary Diseases / Q000000981:diagnostic imaging* / Q000209:etiology; D010024:Osteoporosis / Q000000981:diagnostic imaging* / Q000209:etiology; D010052:Ovariectomy; D011859:Radiography; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013977:Tibia / Q000000981:diagnostic imaging
D002136:Calcium, Dietary