Massive splenomegaly and Epstein-Barr virus-associated infectious mononucleosis in a patient with Gaucher disease.
OBJECTIVE
Gaucher disease should be considered in the differential diagnosis of a patient with Epstein-Barr virus (EBV) infection who has unexplained or disproportionate splenomegaly.


METHODS
A previously asymptomatic adolescent with EBV-associated infectious mononucleosis and massive splenomegaly is described. He was found to have Gaucher disease on bone marrow biopsy, which was performed to exclude a hematologic malignancy. The diagnosis was confirmed by assay of beta-glucosidase enzyme activity.


RESULTS
Regression of splenomegaly and improving hematologic indices.


CONCLUSIONS
Patients with infectious mononucleosis and disproportionate organomegaly should be investigated to exclude a hematologic malignancy or an underlying storage disorder such as Gaucher disease.
Eapen
M
M
Department of Hematology/Oncology, University of Minnesota, Minneapolis, USA.
Hostetter
M
M
Neglia
J P
JP
D000293:Adolescent; D005776:Gaucher Disease / Q000150:complications*; D004854:Herpesvirus 4, Human; D006801:Humans; D007244:Infectious Mononucleosis / Q000150:complications* / Q000821:virology; D008297:Male; D013163:Splenomegaly / Q000209:etiology* / Q000821:virology