Y chromosome and male infertility.
Recent genome analysis of the Y chromosome has increased the number of genes found on this chromosome markedly. Many of these genes in the part of the Y chromosome that does not undergo recombination with the X chromosome are members of gene families. Evolutionary considerations imply that genes on the Y chromosome will degenerate unless they have male advantageous or female deleterious functions. Spermatogenesis is an example of a male advantageous function and genes in three regions of the human Y chromosome have been promoted as candidate male fertility factors.
Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh, UK.
H J
HJ
Cooke
D000818:Animals; D002874:Chromosome Mapping; D000075364:Deleted in Azoospermia 1 Protein; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D051379:Mice; D009687:Nuclear Proteins; D016601:RNA-Binding Proteins / Q000235:genetics; D011995:Recombination, Genetic / Q000235:genetics; D013091:Spermatogenesis / Q000235:genetics* / Q000502:physiology; D014998:Y Chromosome / Q000235:genetics*
C095668:DAZ1 protein, human; D000075364:Deleted in Azoospermia 1 Protein; D009687:Nuclear Proteins; C501499:RBMY1A1 protein, human; D016601:RNA-Binding Proteins; C501500:Rbmy protein, mouse