Multiple endometrial stromal nodules with sparse cysts and glands in the lung--a nodular variation of endometriosis that may mimic metastases of sarcoma.
We report an unusual case of a nodular variation of pulmonary endometriosis. To our knowledge, there is no previous report on a morphological investigation of this entity. The etiology of this rare condition is still a matter of discussion. The well-circumscribed nodular mass is composed of cells identical to, or closely resembling, those of endometrial stroma containing sparse cysts and glands. Immunohistochemically, the cells showed an extensive co-expression of cytokeratin AE1/AE3 and vimentin and were highly positive for progesterone receptor (PRICA) and estrogen receptor (ERICA). Cells lining the cysts and glands as a monolayer were reactive for Ber-Ep4, cytokeratin Pan and cytokeratin AE1/AE3 and negative to all other markers used including PRICA and ERICA. The differential diagnosis of this entity included fibrous tumor of the pleura and metastatic low-grade-endometrial-stromal-sarcoma. The morphological findings are correlated with immunohistochemical studies and results of cell image analysis. This study details the clinicopathological features of the nodular variation of pulmonary endometriosis.
Institute of Pathology and Bacteriology, Vienna, Austria. hum@pkb.magwien.gv.at
M
M
Huber
F
F
Wierrani
G
G
Böhm
H
H
Hauck
F
F
Lintner
W
W
Grünberger
D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D003560:Cysts / Q000473:pathology; D004247:DNA / Q000032:analysis; D003937:Diagnosis, Differential; D016889:Endometrial Neoplasms / Q000473:pathology*; D004715:Endometriosis / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005350:Fibroma / Q000473:pathology; D006801:Humans; D019044:Image Cytometry; D007091:Image Processing, Computer-Assisted; D007124:Immunoenzyme Techniques; D008171:Lung Diseases / Q000378:metabolism / Q000473:pathology*; D010997:Pleural Neoplasms / Q000473:pathology; D011003:Ploidies; D018203:Sarcoma, Endometrial Stromal / Q000556:secondary*; D017154:Stromal Cells / Q000378:metabolism / Q000473:pathology; D014057:Tomography, X-Ray Computed
D014408:Biomarkers, Tumor; D004247:DNA