Relationship between glycosylated hemoglobin and the prevalence of proteinuria in Japanese men.
A total of 5,174 Japanese men were included in a cross-sectional study to examine the relationship between the glycated hemoglobin (HbA1C) level and the prevalence of proteinuria as determined using a reagent strip. The prevalence of proteinuria rose significantly at HbA1C levels above 5.9%, whereas no relationship was observed at HbA1C levels below 5.9%. Multiple logistic regression analysis showed that blood pressure and a family history of diabetes were independent factors associated with proteinuria in subjects with a HbA1C below 5.9% who were not under medication for diabetes. In contrast, HbA1C, obesity and smoking were associated with proteinuria in subjects who were under medication for diabetes and/or have a HbA1C above 5.9%. These findings suggest that maintaining a HbA1C level below 5.9%, non-smoking and a standard body weight may reduce the prevalence of proteinuria in Japanese men. Healthy life-style and standard body weight are especially important for subjects with a family history of diabetes.
Department of Clinical Laboratory Medicine, Faculty of Medicine, University of Tokyo.
Y
Y
Hashimoto
A
A
Futamura
N
N
Watanabe
M
M
Togo
H
H
Sato
M
M
Hara
K
K
Tsukamoto
S
S
Kimura
K
K
Nakahara
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood / Q000652:urine; D001835:Body Weight; D003430:Cross-Sectional Studies; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000097:blood / Q000652:urine; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications / Q000652:urine; D015995:Prevalence; D011507:Proteinuria / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D012189:Retrospective Studies; D012307:Risk Factors; D012907:Smoking / Q000097:blood / Q000652:urine
D015415:Biomarkers; D006442:Glycated Hemoglobin