Multiple endometrial stromal nodules with sparse cysts and glands in the lung--a nodular variation of endometriosis that may mimic metastases of sarcoma.
We report an unusual case of a nodular variation of pulmonary endometriosis. To our knowledge, there is no previous report on a morphological investigation of this entity. The etiology of this rare condition is still a matter of discussion. The well-circumscribed nodular mass is composed of cells identical to, or closely resembling, those of endometrial stroma containing sparse cysts and glands. Immunohistochemically, the cells showed an extensive co-expression of cytokeratin AE1/AE3 and vimentin and were highly positive for progesterone receptor (PRICA) and estrogen receptor (ERICA). Cells lining the cysts and glands as a monolayer were reactive for Ber-Ep4, cytokeratin Pan and cytokeratin AE1/AE3 and negative to all other markers used including PRICA and ERICA. The differential diagnosis of this entity included fibrous tumor of the pleura and metastatic low-grade-endometrial-stromal-sarcoma. The morphological findings are correlated with immunohistochemical studies and results of cell image analysis. This study details the clinicopathological features of the nodular variation of pulmonary endometriosis.
Huber
M
M
Institute of Pathology and Bacteriology, Vienna, Austria. hum@pkb.magwien.gv.at
Wierrani
F
F
Böhm
G
G
Hauck
H
H
Lintner
F
F
Grünberger
W
W
D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D003560:Cysts / Q000473:pathology; D004247:DNA / Q000032:analysis; D003937:Diagnosis, Differential; D016889:Endometrial Neoplasms / Q000473:pathology*; D004715:Endometriosis / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005350:Fibroma / Q000473:pathology; D006801:Humans; D019044:Image Cytometry; D007091:Image Processing, Computer-Assisted; D007124:Immunoenzyme Techniques; D008171:Lung Diseases / Q000378:metabolism / Q000473:pathology*; D010997:Pleural Neoplasms / Q000473:pathology; D011003:Ploidies; D018203:Sarcoma, Endometrial Stromal / Q000556:secondary*; D017154:Stromal Cells / Q000378:metabolism / Q000473:pathology; D014057:Tomography, X-Ray Computed
D014408:Biomarkers, Tumor; D004247:DNA