Identification of a pharmacologically active metabolite of mycophenolic acid in plasma of transplant recipients treated with mycophenolate mofetil.
Schütz
E
E
Abteilung Klinische Chemie, Zentrum Innere Medizin, Georg-August-Universität, Robert Koch Strasse 40, D-37075 Göttingen, Germany. eschuetz@med.uni-goettingen.de
Shipkova
M
M
Armstrong
V W
VW
Wieland
E
E
Oellerich
M
M
D002851:Chromatography, High Pressure Liquid; D004926:Escherichia coli / Q000378:metabolism; D006801:Humans; D007168:IMP Dehydrogenase / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D007166:Immunosuppressive Agents / Q000378:metabolism* / Q000627:therapeutic use; D016031:Liver Transplantation; D009173:Mycophenolic Acid / Q000031:analogs & derivatives* / Q000097:blood* / Q000378:metabolism / Q000627:therapeutic use; D011355:Prodrugs / Q000378:metabolism* / Q000627:therapeutic use; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors / Q000096:biosynthesis
D007166:Immunosuppressive Agents; D011355:Prodrugs; D011994:Recombinant Proteins; D007168:IMP Dehydrogenase; D009173:Mycophenolic Acid