Host cell interactions and signalling with Neisseria gonorrhoeae.
Neisseria gonorrhoeae is a highly adapted human pathogen that utilises multiple adhesins to interact with a variety of host cell receptors. Recently, substantial progress has been made in unravelling the signalling events induced by N. gonorrhoae that can lead to cytoskeletal reorganisation, invasion or phagocytic uptake, intraphagosomal accommodation, nuclear signalling, cytokine/chemokine release and apoptosis.
Max-Planck-Institut für Infektionsbiologie Abteilung Molekulare Biologie Monbijou Str 2 10117 Berlin Germany.
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Naumann
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Rudel
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Meyer
D000818:Animals; D000942:Antigens, Bacterial / Q000378:metabolism; D015703:Antigens, CD / Q000378:metabolism; D000943:Antigens, Differentiation / Q000378:metabolism; D017209:Apoptosis; D001426:Bacterial Proteins / Q000378:metabolism; D016466:CHO Cells; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002460:Cell Line; D006224:Cricetinae; D016207:Cytokines / Q000096:biosynthesis; D004847:Epithelial Cells / Q000382:microbiology / Q000502:physiology*; D036781:Fimbriae Proteins; D006367:HeLa Cells; D019812:Heparan Sulfate Proteoglycans / Q000378:metabolism; D006801:Humans; D009092:Mucous Membrane / Q000382:microbiology / Q000502:physiology; D016328:NF-kappa B / Q000378:metabolism; D009344:Neisseria gonorrhoeae / Q000737:chemistry / Q000472:pathogenicity*; D018272:Porins / Q000378:metabolism; D015398:Signal Transduction; D013045:Species Specificity; D018808:Transcription Factor AP-1 / Q000378:metabolism; D014774:Virulence
D000942:Antigens, Bacterial; D015703:Antigens, CD; D000943:Antigens, Differentiation; D001426:Bacterial Proteins; C069847:CD66 antigens; D015815:Cell Adhesion Molecules; D016207:Cytokines; D019812:Heparan Sulfate Proteoglycans; D016328:NF-kappa B; D018272:Porins; D018808:Transcription Factor AP-1; C050308:opacity proteins; C079208:pilC protein, Neisseria gonorrhoeae; D036781:Fimbriae Proteins