Cytoplasmic dynein and dynactin in cell division and intracellular transport.
Since the initial discovery of cytoplasmic dynein, it has become apparent that this microtubule-based motor is involved in several cellular functions including cell division and intracellular transport. Another multisubunit complex, dynactin, may be required for most, if not all, cytoplasmic dynein-driven activities and may provide clues to dynein's functional diversity. Recent genetic and biochemical findings have illuminated the cellular roles of dynein and dynactin and provided insight into the functional mechanism of this complex motor.
Karki
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University of Pennsylvania Department of Animal Biology 143 Rosenthal Building 3800 Spruce Street Philadelphia PA 19104-6046 USA. karkis@vet.upenn.edu
Holzbaur
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D000705:Anaphase; D000818:Animals; D001233:Aspergillus nidulans / Q000378:metabolism; D001692:Biological Transport; D002455:Cell Division / Q000502:physiology*; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism*; D000072159:Dynactin Complex; D004398:Dyneins / Q000378:metabolism*; D006056:Golgi Apparatus / Q000378:metabolism; D006801:Humans; D018386:Kinetochores / Q000378:metabolism; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D008941:Spindle Apparatus / Q000378:metabolism
D000072159:Dynactin Complex; D008869:Microtubule-Associated Proteins; D004398:Dyneins