Membrane protein folding.
Investigating the in vitro refolding of proteins that naturally reside in biological membranes is a notoriously difficult task. Biophysical studies on model systems are beginning to provide a sound physical basis for membrane protein folding that should help to alleviate this problem. Highlights of these studies include insights into the interaction of transmembrane alpha helices, as well as into the important role that membrane lipids play in folding.
Department of Biochemistry, Imperial College of Science, Technology andMedicine, South Kensington, London SW7 2AY, UK. p.j.booth@ic.ac.uk
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D001436:Bacteriorhodopsins / Q000737:chemistry; D055592:Biophysical Phenomena; D001703:Biophysics; D002352:Carrier Proteins / Q000737:chemistry; D066298:In Vitro Techniques; D007473:Ion Channels / Q000737:chemistry; D008563:Membrane Lipids / Q000737:chemistry; D008565:Membrane Proteins / Q000737:chemistry*; D008958:Models, Molecular; D017510:Protein Folding; D017433:Protein Structure, Secondary; D011956:Receptors, Cell Surface / Q000737:chemistry
D002352:Carrier Proteins; D007473:Ion Channels; D008563:Membrane Lipids; D008565:Membrane Proteins; D011956:Receptors, Cell Surface; D001436:Bacteriorhodopsins