Spontaneous neoplastic lesions in Harlan Sprague-Dawley rats.
In a 24-months study, the spontaneous tumour spectrum of the Hsd:Sprague-Dawley stock was examined. Pituitary gland tumours were found in 20% of the males and 39% of the females. This relatively low incidence, compared to other SPRD stocks, had little effect on the survival of females (50%), due to the high incidence (76%) of mammary gland tumours (predominantly fibroadenomas) that resulted in unscheduled sacrifices of many females. Other common neoplasms in Hsd:Sprague-Dawley rats were benign medullary tumours (27% in males, 11% in females), C-cell adenomas (23% in males, 28% in females), and endometrial stromal polyps (22% in females).
Bristol-Myers Squibb, Department of Toxicology, Regensburg, Germany.
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J
Kaspareit
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S
Rittinghausen
D000818:Animals; D001835:Body Weight; D005260:Female; D008297:Male; D009369:Neoplasms / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley