Photopolymerizable degradable polyanhydrides with osteocompatibility.
We have developed a new family of photopolymerizable, methacrylated anhydride monomers and oligomers that combine high strength, controlled degradation, and photoprocessibility in a singular system. Networks with degradation times ranging from 1 week to nearly 1 year and that retain up to 90% of their tensile modulus at 40% mass loss are attainable. In vivo studies in rats have shown that these networks possess excellent osteocompatibility. These combined properties could offer many advantages in medical applications ranging from dentistry to orthopedics.
Department of Chemical Engineering, University of Colorado, Boulder 80309, USA.
K S
KS
Anseth
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Shastri
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R
Langer
D000812:Anhydrides / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials; D001842:Bone and Bones; D006868:Hydrolysis; D010777:Photochemistry; D011108:Polymers; D051381:Rats; D017207:Rats, Sprague-Dawley; D013055:Spectrophotometry, Infrared / Q000379:methods
D000812:Anhydrides; D001672:Biocompatible Materials; D011108:Polymers