An alcohol model of impaired inhibitory control and its treatment in humans.
This study developed a model of impaired inhibitory control in humans to test the efficacy of treatments for this deficit. Male social drinkers (N = 35) practiced a "go-stop" task that measured response inhibition. They then were assigned to 1 of 5 groups (n = 7) that performed the task under a different treatment. The model of impaired inhibitory control was provided by administering 0.62 g/kg alcohol to 1 group (A), whose response inhibition was compared with a placebo group (P). The other 3 groups received 0.62 g/kg alcohol plus a treatment designed to ameliorate alcohol impairment of inhibitory control: behavioral reinforcement (B), or 4.4 mg/kg caffeine (C), or a combination of both (B + C). Alcohol impaired inhibitory control, and all 3 treatments (B, C, and B + C) counteracted the impairment. The findings indicate that alcohol impairment of response inhibition may provide a useful human model to test conditions that may ameliorate or exacerbate deficits in behavioral control induced by drugs or other factors.
Fillmore
M T
MT
Department of Psychology, University of Waterloo, Ontario, Canada. mfillmor@watarts.uwaterloo.ca
Vogel-Sprott
M
M
D000328:Adult; D000428:Alcohol Drinking / Q000523:psychology*; D000434:Alcoholic Beverages; D002492:Central Nervous System Depressants / Q000097:blood / Q000494:pharmacology*; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D008960:Models, Psychological; D011930:Reaction Time / Q000187:drug effects
D002492:Central Nervous System Depressants; D000431:Ethanol