Carbamazepine-induced sensorineural hearing loss.
Carbamazepine is a commonly prescribed anticonvulsant medication that affects various levels of the nervous system. We report a case of temporary sensorineural hearing loss in a patient after overdosing with 36 g of carbamazepine. Six days after the overdose, the patient complained of bilateral hearing loss and tinnitus. Audiograms revealed a 30- to 40-dB sensorineural hearing loss bilaterally. Another audiogram 2 weeks later showed a complete recovery in both ears accompanied by a clinical resolution in audiovestibular symptoms. Carbamazepine is used to treat partial and generalized seizures, trigeminal neuralgia, and bipolar illness. Adverse effects are not common but most frequently include dizziness, drowziness, nausea, and skin rashes; rare complications are agranulocytosis, bradycardia, and heart block. Documented hearing loss as a side effect of carbamazepine has not been reported, to our knowledge.
de la Cruz
M
M
Department of Otolaryngology, Dalhousie University, Faculty of Medicine, Halifax, Nova Scotia, Canada.
Bance
M
M
D000328:Adult; D000927:Anticonvulsants / Q000506:poisoning*; D002220:Carbamazepine / Q000506:poisoning*; D062787:Drug Overdose / Q000175:diagnosis*; D005260:Female; D006312:Hearing Loss, Bilateral / Q000139:chemically induced* / Q000175:diagnosis; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D008575:Meniere Disease / Q000139:chemically induced / Q000175:diagnosis; D013069:Speech Reception Threshold Test; D013406:Suicide, Attempted
D000927:Anticonvulsants; D002220:Carbamazepine