[Duchenne muscular dystrophy. Effects of vitamin E administration on urinary luminescence].
BACKGROUND
Urinary luminescence is increased in patients with Duchenne muscular dystrophy, probably due to the higher oxidative stress present in this disease.


OBJECTIVE
To assess the effects of vitamin E supplementation on urinary luminescence in children with Duchenne muscular dystrophy.


METHODS
Eighteen children with muscular dystrophy aged 12.2 years old and nine control children aged 10 years old, received 400 IU/day of vitamin E during one month. Prior to supplementation and twice a week thereafter, spot urine samples were obtained to measure urinary luminescence in a scintillation counter.


RESULTS
There was a wide variability in urinary luminescence within and between children. Mean values decreased after vitamin E supplementation in six of nine controls and in 12 of 18 children with muscular dystrophy.


CONCLUSIONS
Vitamin E supplementation significantly decreases urinary luminescence in healthy children and in patients with Duchenne muscular dystrophy. Therefore, it could be useful for the treatment of this disease.
Pizarro
M
M
Departamento de Química, Facultad de Química y Biología, Universidad de Santiago de Chile.
Lissi
E
E
Reyes
J
J
Holmgren
J
J
D000293:Adolescent; D015415:Biomarkers / Q000652:urine; D002648:Child; D003404:Creatinine / Q000652:urine; D006801:Humans; D008163:Luminescent Measurements; D008297:Male; D009136:Muscular Dystrophies / Q000188:drug therapy / Q000503:physiopathology / Q000652:urine*; D018384:Oxidative Stress; D014810:Vitamin E / Q000008:administration & dosage*
D015415:Biomarkers; D014810:Vitamin E; D003404:Creatinine