Dietary effect of EPA-rich and DHA-rich fish oils on the immune function of Sprague-Dawley rats.
The dietary effect of fish oils (FOs) rich in eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) on the immune function of Sprague-Dawley rats was compared with that of safflower oil. After 3 weeks of feeding at the 10% level of a dietary fat, the IgG and IgM production by splenocytes and IgG production by mesenteric lymph node (MLN) lymphocytes were significantly higher in the FO-fed rats, while no significant difference was found in IgA or IgE productivity by both the spleen and MLN lymphocytes. In the FO-fed rats, peritoneal exudate cells released a lower amount of LTB4, reflecting their lower arachidonic acid level, and a higher amount of LTB5, reflecting their higher EPA level in phospholipids. On these EPA-rich FO exerted a stronger effect than DHA-rich FO immune functions.
Laboratory of Food Science, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.
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Hung
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Kaku
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Yunoki
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Ohkura
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Gu
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Ikeda
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Sugano
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Yazawa
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Yamada
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D004281:Docosahexaenoic Acids / Q000032:analysis / Q000494:pharmacology*; D015118:Eicosapentaenoic Acid / Q000031:analogs & derivatives / Q000032:analysis / Q000096:biosynthesis / Q000494:pharmacology*; D005395:Fish Oils / Q000737:chemistry / Q000494:pharmacology*; D007109:Immunity / Q000187:drug effects*; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D007975:Leukotriene B4 / Q000031:analogs & derivatives / Q000096:biosynthesis; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012450:Safflower Oil / Q000494:pharmacology; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D000276:Adjuvants, Immunologic; D005395:Fish Oils; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D017392:Thiobarbituric Acid Reactive Substances; D007975:Leukotriene B4; D004281:Docosahexaenoic Acids; D012450:Safflower Oil; C040212:leukotriene B5; D015118:Eicosapentaenoic Acid