No association between a polymorphic CAG repeat in the human potassium channel gene hKCa3 and bipolar disorder.
A recent case-control study suggested that modest enlargements of a CAG repeat in the hKCa3 potassium channel may be associated with bipolar disorder. We tried to replicate this result in a UK Caucasian sample of 203 DSM-IV bipolar I disorder patients and 206 controls group-matched for age and sex. Using the same model of analysis as the earlier study, bipolar probands did not have a higher frequency of alleles with greater than 19 repeats than controls (chi2 = 1.44, 1 df, P = 0.23). Similarly, comparison of the distributions of repeat sizes between probands and controls did not approach statistical significance (Mann-Whitney U test, P = 0.35). We conclude that our data provide no support for the hypothesis that variation at the hKCa3 gene contributes to susceptibility to bipolar disorder.
Division of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK.
C A
CA
Guy
T
T
Bowen
N
N
Williams
I R
IR
Jones
F
F
McCandless
P
P
McGuffin
M J
MJ
Owen
N
N
Craddock
M C
MC
O'Donovan
D000328:Adult; D000483:Alleles; D001714:Bipolar Disorder / Q000209:etiology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D015221:Potassium Channels / Q000235:genetics*; D024681:Potassium Channels, Calcium-Activated; D051640:Small-Conductance Calcium-Activated Potassium Channels; D018911:Trinucleotide Repeats / Q000235:genetics*
C406328:KCNN3 protein, human; D015221:Potassium Channels; D024681:Potassium Channels, Calcium-Activated; D051640:Small-Conductance Calcium-Activated Potassium Channels