Association of FXIII Val34Leu with decreased risk of myocardial infarction in Finnish males.
Factor XIII is a transglutaminase that crosslinks fibrin in the last steps of the coagulation process. A few polymorphic sites have been identified in this gene, one of them being a point mutation (FXIII Val34Leu), leading to an amino acid change of valine to leucine. Recently, in British patients, FXIII 34Leu allele was suggested to be associated with a decreased incidence of myocardial infarction (MI). PAI-1 4G/4G genotype seemed to lessen the beneficial effect of FXIII 34Leu allele. The aim of our study was to further investigate the possible protective role of the FXIII 34Leu allele against MI and its suggested interaction with the PAI-1 4G/5G polymorphism. We carried out genotype analyses for FXIII Val34Leu using solid-phase minisequencing in two independent Finnish study groups. In our study, the FXIII 34Leu allele was associated with a lower risk of MI (P = 0.009), however, the PAI-1 4G allele showed no interaction with this polymorphism. To establish the population frequency of the FXIII 34Leu allele and to study the possible variations in Finland four DNA pools from different geographical areas of Finland were genotyped. No significant differences in the allele frequencies were observed (21-28%) except in the Eastern Kainuu area (13%), an area with an increased risk of mortality from coronary artery disease (CAD), supporting the results presented above. The association of FXIII 34Leu variant with a lower incidence of myocardial infarction suggests a new role for FXIII in a polygenic thrombotic disease.
Department of Clinical Chemistry and Biomedicine, Helsinki University Central Hospital, Finland.
U
U
Wartiovaara
M
M
Perola
H
H
Mikkola
K
K
Tötterman
V
V
Savolainen
A
A
Penttilä
P J
PJ
Grant
M J
MJ
Tikkanen
E
E
Vartiainen
P J
PJ
Karhunen
L
L
Peltonen
A
A
Palotie
D000483:Alleles; D004247:DNA / Q000032:analysis; D017931:DNA Primers / Q000737:chemistry; D005176:Factor XIII / Q000235:genetics*; D005342:Fibrinolysis / Q000235:genetics*; D005387:Finland / Q000453:epidemiology; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology* / Q000235:genetics*; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics; D011110:Polymorphism, Genetic; D015995:Prevalence; D012307:Risk Factors
D017931:DNA Primers; D005819:Genetic Markers; D017395:Plasminogen Activator Inhibitor 1; D004247:DNA; D005176:Factor XIII