[Characteristics of anti-microbial agents and its clinical choice for H. pylori treatment].
Eradication of Helicobacter pylori (H. pylori) is now established as main treatment of upper-gastrointestinal diseases. Resistance to H. pylori and acid condition in the stomach were important factors which influenced H. pylori eradication. Recolonized H. pylori strains will be easily resistant to metronidazole and clarithromycin, whereas almost all of H. pylori strains are sensitive to amoxicillin. On the other hand, amoxicillin targets cell wall biosynthesis and clarithromycin inhibits protein synthesis of Helicobacter pylori mainly in the growth phase which induced high intragastric pH condition, however, metronidazole targets DNA and, therefore, is independent of the stationary or growth phase distribution. To established a optimal regimen for Helicobacter pylori treatment, several factors included them should be account according to the parmacokinetical standings.
Department of Endoscopy, Kobe University School of Medicine.
N
N
Aoyama
D
D
Shirasaka
T
T
Sakai
K
K
Shirakawa
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001729:Bismuth / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination; D005744:Gastric Acid; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009593:Nitroimidazoles / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D009593:Nitroimidazoles; D001729:Bismuth