Protective effect of HD-03, a herbal formulation, against various hepatotoxic agents in rats.
HD-03 is a polyherbal formulation containing plant drugs which are known for their hepatoprotective properties in the Ayurvedic system of medicine. In the present study, the formulation was evaluated for its protective effect against diverse hepatotoxic agents viz., paracetamol, thioacetamide and isoniazid. Treatment with HD-03 led to significant amelioration of toxin-induced changes in the biochemical parameters. Since the protective effect of HD-03 was observed in all three types of intoxication, which are different in their primary mechanism of inducing hepatotoxicity, a protective mode of action of HD-03, not specific to the hepatotoxin, is suggested.
R&D Centre, The Himalaya Drug Company, Makali, Bangalore, India.
S K
SK
Mitra
M V
MV
Venkataranganna
R
R
Sundaram
S
S
Gopumadhavan
D000082:Acetaminophen / Q000633:toxicity; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000503:physiopathology / Q000517:prevention & control*; D005260:Female; D007538:Isoniazid / Q000633:toxicity; D008111:Liver Function Tests; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013853:Thioacetamide / Q000633:toxicity
C119007:HD 03 polyherbal; D010936:Plant Extracts; D013853:Thioacetamide; D000082:Acetaminophen; D007538:Isoniazid