Effect of nondigestible oligosaccharides on large-bowel functions, blood lipid concentrations and glucose absorption in young healthy male subjects.
OBJECTIVE
To study the effect of the intake of 15 g nondigestible oligosaccharides per day on various parameters of large-bowel function, as well as on blood lipid concentrations and glucose absorption in man.


METHODS
Latin square, randomized, double-blind, diet-controlled.


METHODS
Metabolic research unit.


METHODS
Twelve apparently healthy men (mean age 23 years), recruited from the Institute's pool of volunteers, no drop-outs.


METHODS
Four treatment periods of 3 weeks: inulin, fructo-oligosaccharides (FOS), galacto-oligosaccharides (GOS) and control; analyses of stool weight, intestinal transit, faecal pH, short-chain fatty acids, bile acids, faecal enzymes, blood lipids and glucose absorption.


RESULTS
As compared to the control treatment: higher concentration of faecal acetate (inulin and GOS, P < 0.05) and valerate (inulin, P < 0.05), significantly lower concentration of faecal deoxycholic acid (inulin and FOS, P < 0.05 and P< 0.02, respectively) and beta-glucuronidase activity (inulin and GOS, P < 0.05 and P < 0.02 respectively). Other changes of faecal parameters and those of blood lipids and glucose absorption were statistically not significant.


CONCLUSIONS
RESULTS indicate that nondigestible oligosaccharides are (partly) fermented in the human colon, but in healthy young men the effects are limited. Also the consumption of 15 g nondigestible oligosaccharides does not seem to alter blood lipid concentrations and glucose absorption in our young healthy adults.
van Dokkum
W
W
TNO Nutrition and Food Research Institute, Zeist, The Netherlands.
Wezendonk
B
B
Srikumar
T S
TS
van den Heuvel
E G
EG
D000328:Adult; D001774:Blood Chemical Analysis; D004043:Dietary Fiber / Q000008:administration & dosage / Q000378:metabolism*; D004311:Double-Blind Method; D004435:Eating; D005243:Feces / Q000737:chemistry / Q000201:enzymology; D005947:Glucose / Q000493:pharmacokinetics*; D005951:Glucose Tolerance Test; D005966:Glucuronidase / Q000032:analysis; D006801:Humans; D007408:Intestinal Absorption; D007420:Intestine, Large / Q000502:physiology*; D008055:Lipids / Q000097:blood*; D008297:Male; D009844:Oligosaccharides / Q000008:administration & dosage / Q000378:metabolism*; D011795:Surveys and Questionnaires; D014368:Tryptophanase / Q000032:analysis; D014510:Urease / Q000032:analysis; D001617:beta-Glucosidase / Q000032:analysis
D004043:Dietary Fiber; D008055:Lipids; D009844:Oligosaccharides; D001617:beta-Glucosidase; D005966:Glucuronidase; D014510:Urease; D014368:Tryptophanase; D005947:Glucose