Accessory protein regulation of microtubule dynamics throughout the cell cycle.
A number of accessory proteins capable of stabilizing or destabilizing microtubule polymers in dividing cells have been identified recently. Many of these accessory proteins are modified and regulated by cell-cycle-dependent phosphorylation. Through this regulation, microtubule dynamics are modified to generate rapid microtubule turnover during mitosis. In general, although some microtubule-stabilizing proteins are inactivated at entry into mitosis, a critical balance between microtubule stabilizers and destabilizers is necessary for assembly of the mitotic spindle.
Cassimeris
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Department of Biological Sciences 111 Research Drive Lehigh University Bethlehem PA 18015 USA. lc07@lehigh.edu
D000818:Animals; D017173:Caenorhabditis elegans; D002453:Cell Cycle / Q000502:physiology*; D008869:Microtubule-Associated Proteins / Q000502:physiology*; D008870:Microtubules / Q000737:chemistry / Q000502:physiology*; D008938:Mitosis / Q000502:physiology; D010766:Phosphorylation; D013997:Time Factors; D014981:Xenopus
D008869:Microtubule-Associated Proteins