Virulence gene regulation by peptides in staphylococci and other Gram-positive bacteria.
In staphylococci, autoinducing peptides activate agr. a global regulator of the expression of genes encoding virulence factors and other exoproteins. During the past year, there have been major advances in the structure-function analysis of these peptides and the regulation of a virulence factor by an autoinducing peptide in pneumococci has been demonstrated.
Novick
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Skirball Institute of Biomolecular Medicine New York University School of Medicine 540 First Ave 2nd floor New York NY 10016 USA. novick@saturn.med.nyu.edu
Muir
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TW
D000595:Amino Acid Sequence; D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism*; D004265:DNA Helicases / Q000494:pharmacology; D004268:DNA-Binding Proteins; D004195:Disease Models, Animal; D015964:Gene Expression Regulation, Bacterial; D051379:Mice; D009154:Mutation; D010456:Peptides, Cyclic; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction; D015534:Trans-Activators / Q000494:pharmacology
C414532:AgrD protein, Staphylococcus; D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D010456:Peptides, Cyclic; D015534:Trans-Activators; C110354:rap protein, bacteria; C045264:replication initiator protein; D004265:DNA Helicases