Left ventricular mass regression with amlodipine in elderly hypertensives.
We evaluated effect of amlodipine therapy on left ventricular (LV) mass and function indices in 34 elderly hypertensives having echocardiographic evidence of left ventricular hypertrophy (LVH). LV mass and LV function indices were evaluated before and after 4 months of effective amlodipine therapy. Fourteen patients completed the study. Blood pressure was effectively controlled in all the patients; dose requirement of amlodipine being 5 mg/day in 8 and 10 mg/day in 6 patients. We found significant regression of LV mass indices such as thickness of interventricular septum (IVS) and left ventricular posterior wall (LVPW), and LV mass index after 4 months of amlodipine therapy. However, LV function indices did not alter following treatment. In conclusion, amlodipine therapy besides effectively controlling BP in elderly hypertensives, produced significant regression of LV mass indices without affecting the LV function.
Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
N K
NK
Singh
S K
SK
Gupta
B V
BV
Agrawal
D000368:Aged; D000369:Aged, 80 and over; D017311:Amlodipine / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006339:Heart Rate / Q000187:drug effects; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D013318:Stroke Volume / Q000187:drug effects; D016896:Treatment Outcome
D002121:Calcium Channel Blockers; D017311:Amlodipine