Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2-(dimethylamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray structure complexed to d(CG(5-BrU)ACG)2 at 1.3-A resolution.
Chemistry Department, University of Reading, Whiteknights, Reading RG6 6AD, U.K.
A K
AK
Todd
A
A
Adams
J H
JH
Thorpe
W A
WA
Denny
L P
LP
Wakelin
C J
CJ
Cardin
D000166:Acridines / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004264:DNA Topoisomerases, Type I / Q000737:chemistry*; D004250:DNA Topoisomerases, Type II / Q000737:chemistry*; D006860:Hydrogen Bonding; D007364:Intercalating Agents / Q000737:chemistry*; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors
D000166:Acridines; D000970:Antineoplastic Agents; D007364:Intercalating Agents; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors; C058332:N-(2'-(dimethylamino)ethyl)acridine-4-carboxamide; D004264:DNA Topoisomerases, Type I; D004250:DNA Topoisomerases, Type II