[Inhibition of corneal neovascularization--the possibility of inhibition by drug administration].
OBJECTIVE
The anti-angiogenic activity of FR 118487, a new synthetic analog of Scolecobasidium arenarium products, was examined in Japanese white rabbit cornea.


METHODS
We studied both systemic and locally administered FR 118487 (ointment) in a keratoplasty model consisting of corneal neovascularization after implantation of a Wister rat cornea into a rabbit cornea.


RESULTS
Two weeks after the implantation, the maximum length of neovascularization was 3.4 +/- 0.3 mm in control corneas, 0.1 +/- 0.0 mm with systemic FR 118487 administration (10 mg/day) (p < 0.01), 0.1 +/- 0.1 mm with 10% FR118487 ointment (p < 0.001), 1.0 +/- 0.2 mm with 3% FR 118487 ointment (p < 0.001), and 0.9 +/- 0.9 mm with 1% FR 118487 ointment (p < 0.02).


CONCLUSIONS
FR 118487 had a significant effect on inhibition of corneal neovascularization.
Department of Ophthalmology, School of Medicine, Keio University, Tokyo, Japan.
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Mashima
D000818:Animals; D016510:Corneal Neovascularization / Q000517:prevention & control*; D005260:Female; D009824:Ointments; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D013141:Spiro Compounds / Q000008:administration & dosage / Q000494:pharmacology*
C096036:FR 118487; D009824:Ointments; D013141:Spiro Compounds