General anesthetic effects on protein kinase C.
(1) Protein kinase C is a family of phospholipid-dependent protein kinases which are involved in the regulation of diverse cellular functions. (2) Evidence is emerging that certain general anesthetics can stimulate the activity of protein kinase C by interacting with the regulatory domain of the enzyme, possibly with the diacylglycerol binding sites. Anesthetics also potentiate activation-dependent down-regulation of the enzyme. (3) A role for PKC in the mediation and or modulation of the cellular effects of general anesthetics is a potential molecular target for anesthetic action.
Hemmings
H C
HC
Department of Anesthesiology, Cornell University Medical College, New York, NY 10021, USA. hchemmi@mail.med.cornell.edu
D018681:Anesthetics, General / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D011493:Protein Kinase C / Q000378:metabolism*; D051381:Rats; D013574:Synaptosomes / Q000187:drug effects / Q000201:enzymology
D018681:Anesthetics, General; D011493:Protein Kinase C