Interaction of Salmonella with host cells through the centisome 63 type III secretion system.
Salmonella enterica engages host cells in a complex two-way biochemical interaction that results in a variety of responses from both the bacteria and the host cell. Central to this interaction is the function of a type III protein secretion system that delivers effector proteins into the host cell. During the past year we have seen major advances in our knowledge of both the bacterial determinants and the host-signal transduction pathways involved in these interactions. A coherent picture of the mechanisms by which Salmonella engages the host cell is now beginning to emerge.
Section of Microbial Pathogenesis Boyer Center for Molecular Medicine Yale School of Medicine New Haven CT 06536-0812 USA. jorge.galan@yale.edu.
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D018829:Adhesins, Bacterial; D001426:Bacterial Proteins / Q000378:metabolism / Q000648:ultrastructure*; D001483:Base Sequence; D002876:Chromosomes, Bacterial / Q000235:genetics*; D019779:Salmonella enterica / Q000472:pathogenicity*; D015398:Signal Transduction; D014774:Virulence
D018829:Adhesins, Bacterial; D001426:Bacterial Proteins; C079790:PrgH protein, Salmonella typhimurium; C053476:invasin, Yersinia