Genes regulating MHC class I processing of antigen.
The principal pathway of antigen processing that is associated with MHC class I involves three main steps: cytosolic peptide generation, peptide transport into the endoplasmic reticulum and peptide assembly with class I molecules. Recent advances suggest that additional cytosolic proteases complement the proteasome as a source of antigenic peptides. Peptide assembly involves several novel cofactors - including the proteins tapasin and ERp57, which may be important for stabilisation of empty class I molecules as well as quality control after peptide binding. Finally, genetic evidence suggests an important influence of an unidentified gene, in the MHC complex, on MHC class I processing.
INSERM U25 Hôpital Necker, Paris, France. vanendert@necker.fr.
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van Endert
D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters / Q000235:genetics / Q000276:immunology; D000818:Animals; D017951:Antigen Presentation; D017920:Antiporters / Q000235:genetics / Q000276:immunology; D002135:Calcium-Binding Proteins / Q000235:genetics / Q000276:immunology; D037282:Calreticulin; D003546:Cysteine Endopeptidases / Q000235:genetics / Q000276:immunology; D005796:Genes / Q000235:genetics / Q000276:immunology*; D006360:Heat-Shock Proteins / Q000235:genetics / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics / Q000276:immunology; D007535:Isomerases / Q000235:genetics / Q000276:immunology; D026901:Membrane Transport Proteins; D009097:Multienzyme Complexes / Q000235:genetics / Q000276:immunology; D046988:Proteasome Endopeptidase Complex; D019704:Protein Disulfide-Isomerases; D012261:Ribonucleoproteins / Q000235:genetics / Q000276:immunology
D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters; D017920:Antiporters; D002135:Calcium-Binding Proteins; D037282:Calreticulin; D006360:Heat-Shock Proteins; D015395:Histocompatibility Antigens Class I; D007136:Immunoglobulins; D026901:Membrane Transport Proteins; D009097:Multienzyme Complexes; D012261:Ribonucleoproteins; C107762:tapasin; C071692:TAP2 protein, human; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex; D007535:Isomerases; D019704:Protein Disulfide-Isomerases; C085868:PDIA3 protein, human