[Specific drug therapy of acute poisoning].
Antidote therapy is an important component of urgent treatment of acute poisonings. However, due to high specificity of the antidote action they can be effectively and safely used only under certain conditions. According to Ye. A. Luzhnikov's classification, 4 main groups of antidotes are distinguished: toxicotropic, toxicokinetic, symptomatic, and antitoxic immunopreparations. The use of individual antidotes, mainly symptomatic and some toxicotropic and toxicokinetic, is determined by the presence of typical clinical signs of poisoning and the anamnesis. In the rest cases the diagnosis is to be confirmed by laboratory findings, which is particularly important in poisoning with alcohol substitutes and metal compounds. Antidotes can cause side effects and complications, and therefore cannot be used in some cases.
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Ostapenko
D000208:Acute Disease; D000931:Antidotes / Q000009:adverse effects / Q000145:classification; D002614:Chelating Agents / Q000627:therapeutic use; D004492:Edetic Acid / Q000627:therapeutic use; D004630:Emergencies; D019855:Ethylene Glycol / Q000506:poisoning; D000075322:Heavy Metal Poisoning; D006801:Humans; D006931:Hyperbaric Oxygenation; D000432:Methanol / Q000506:poisoning; D011041:Poisoning / Q000175:diagnosis / Q000188:drug therapy*; D011736:Pyridoxine / Q000627:therapeutic use
D000931:Antidotes; D002614:Chelating Agents; D004492:Edetic Acid; D019855:Ethylene Glycol; D011736:Pyridoxine; D000432:Methanol