Dual inhibition of phosphodiesterase 4 and matrix metalloproteinases by an (arylsulfonyl)hydroxamic acid template.
Groneberg
R D
RD
Rhône-Poulenc Rorer, SW8, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA. robert.groneberg@rp-rorer.com
Burns
C J
CJ
Morrissette
M M
MM
Ullrich
J W
JW
Morris
R L
RL
Darnbrough
S
S
Djuric
S W
SW
Condon
S M
SM
McGeehan
G M
GM
Labaudiniere
R
R
Neuenschwander
K
K
Scotese
A C
AC
Kline
J A
JA
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000818:Animals; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D005347:Fibroblasts / Q000201:enzymology; D018093:Gelatinases / Q000037:antagonists & inhibitors; D006168:Guinea Pigs; D006877:Hydroxamic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D008264:Macrophages / Q000201:enzymology; D020781:Matrix Metalloproteinase 1; D020778:Matrix Metalloproteinase 2; D061965:Matrix Metalloproteinase Inhibitors; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors*; D010726:Phosphodiesterase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013450:Sulfones / Q000138:chemical synthesis* / Q000494:pharmacology
D006877:Hydroxamic Acids; D061965:Matrix Metalloproteinase Inhibitors; D010726:Phosphodiesterase Inhibitors; D011480:Protease Inhibitors; D013450:Sulfones; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D018093:Gelatinases; D008666:Metalloendopeptidases; D020778:Matrix Metalloproteinase 2; D020781:Matrix Metalloproteinase 1