Cell biology of Legionella pneumophila.
Legionella pneumophila is the causative agent of a potentially fatal form of pneumonia named Legionnaires' disease. L. pneumophila survives and replicates inside macrophages by preventing phagosome-lysosome fusion. A large number of L. pneumophila genes, called dot or icm, have been identified that are required for intracellular growth. It has recently been shown that the dot/icm genes code for a putative large membrane complex that forms a type IV secretion system used to alter the endocytic pathway.
Department of Molecular Microbiology Washington University School of Medicine 660 S. Euclid Avenue St. Louis MO 63110, USA. jvogel_bpg@opal.tufts.edu
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Vogel
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Isberg
D000656:Amoeba / Q000382:microbiology; D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics; D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins / Q000235:genetics; D003470:Culture Media; D003603:Cytotoxins / Q000096:biosynthesis; D029968:Escherichia coli Proteins; D005798:Genes, Bacterial / Q000235:genetics; D006801:Humans; D016952:Legionella pneumophila / Q000235:genetics / Q000254:growth & development / Q000472:pathogenicity / Q000502:physiology*; D008264:Macrophages / Q000382:microbiology; D008869:Microtubule-Associated Proteins / Q000235:genetics; D033903:Periplasmic Proteins; D012097:Repressor Proteins / Q000235:genetics; D012965:Sodium Chloride; D020298:U937 Cells; D014774:Virulence; D037521:Virulence Factors
D001426:Bacterial Proteins; D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; D003470:Culture Media; D003603:Cytotoxins; D029968:Escherichia coli Proteins; D008869:Microtubule-Associated Proteins; C100857:PTL-1 protein, C elegans; D033903:Periplasmic Proteins; D012097:Repressor Proteins; D037521:Virulence Factors; C076244:trbA protein, E coli; D012965:Sodium Chloride