Chlorambucil-induced inappropriate antidiuresis in a man with chronic lymphocytic leukemia.
The syndrome of inappropriate antidiuretic hormone (SIADH) has been described in patients suffering from leukemia or lymphoma involving the central nervous system. Several alkylating agents have also been associated with this syndrome. We describe a patient with chronic lymphocytic leukemia, without evidence of central nervous system involvement, who suffered from SIADH presumably caused by small doses of chlorambucil.
Endocrinology Department, Hospital de Sant Pau, Barcelona, Spain.
A M
AM
Wägner
S
S
Brunet
J
J
Puig
E
E
Ortega
M
M
Subirà
M
M
Puig
D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects*; D002699:Chlorambucil / Q000009:adverse effects*; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000097:blood / Q000139:chemically induced*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012964:Sodium / Q000097:blood
D018906:Antineoplastic Agents, Alkylating; D002699:Chlorambucil; D012964:Sodium