The effectiveness of single and multiple applications of triple dye on umbilical cord separation time.
The effectiveness of single and multiple applications of triple dye for umbilical cord care in the umbilical cord separation time (UCST) was evaluated in 180 neonates. Seven neonates were excluded, three where the cord stump separation time was uncertain and four to whom contact was lost. The participating neonates were randomly assigned to two groups. Group 1, 101 neonates, were treated with a regimen of a single application of triple dye. Group 2, 79 neonates, were treated with multiple applications of triple dye. Complete information was obtained from 97 neonates (96.2%) in group 1 and 76 (96%) in group 2. The UCST was 12.6 +/- 0.45 (mean +/- SE) days in group 1 and 16.68 +/- 0.65 days in group 2 (P < 0.0001) and showed no significant association with infants' gender, mode of delivery, gravidity, gestational age, birth weight, or hospital stay.


CONCLUSIONS
A single application of triple dye may be a more favourable regimen with a similarly antimicrobial effect, a shorter UCST and may be more cost effective than multiple applications of triple dye in umbilical cord care.
Department of Pediatrics, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.
C F
CF
Hsu
C C
CC
Wang
Y S
YS
Yuh
Y H
YH
Chen
M L
ML
Chu
D000890:Anti-Infective Agents / Q000008:administration & dosage*; D016009:Chi-Square Distribution; D004338:Drug Combinations; D005260:Female; D005840:Gentian Violet / Q000008:administration & dosage*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011370:Proflavine / Q000008:administration & dosage*; D011446:Prospective Studies; D000644:Quaternary Ammonium Compounds / Q000008:administration & dosage*; D013997:Time Factors; D014470:Umbilical Cord / Q000187:drug effects* / Q000382:microbiology
D000890:Anti-Infective Agents; D004338:Drug Combinations; D000644:Quaternary Ammonium Compounds; C014234:Triple Dye; D011370:Proflavine; D005840:Gentian Violet