A high-Mr glycoprotein fraction from cow's milk potent in inhibiting replication of human rotavirus in vitro.
Rotavirus is the major cause of infectious diarrhea in infants and young children all over the world. We have found that a high-M(r) glycoprotein fraction from cow's milk is potent in inhibiting replication of human rotaviruses in vitro. Since the activity seems to be unique and specific, this fraction may be useful as a novel agent for treatment or prevention of rotavirus diarrhea.
Kanamaru
Y
Y
Department of Food Science, Faculty of Agriculture, Gifu University, Japan. kanamaru@cc.gifu-u.ac.jp
Etoh
M
M
Song
X G
XG
Mikogami
T
T
Hayasawa
H
H
Ebina
T
T
Minamoto
N
N
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002417:Cattle; D002675:Child, Preschool; D003967:Diarrhea / Q000517:prevention & control; D006023:Glycoproteins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007223:Infant; D008892:Milk / Q000737:chemistry; D008894:Milk Proteins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008970:Molecular Weight; D012401:Rotavirus / Q000187:drug effects* / Q000472:pathogenicity / Q000502:physiology*; D012400:Rotavirus Infections / Q000517:prevention & control; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D006023:Glycoproteins; D008894:Milk Proteins