Skin eruption with gabapentin in a patient with repeated AED-induced Stevens-Johnson's syndrome.
Skin eruptions have been reported with the use of all antiepileptic drugs and there is a significant risk of cross-reactivity between these agents in causing serious eruptions such as Stevens-Johnson's syndrome. Gabepentin is usually considered a safe agent for patients with a previous history of drug allergies and there have been no cases of skin eruption reported to the gabapentin post marketing surveillance. We report a patient who had severe Stevens-Johnson's syndrome induced by phenytoin and later by carbamazepine. Subsequent use of gabapentin also resulted in a skin eruption which was limited to the lower extremities but without systemic or mucosal involvement. This case suggests that patients with a strong history of drug-induced idiosyncratic reactions may experience such reactions to gabapentin as well.
Department of Neurology, University of Miami, Florida 33136, USA.
J C
JC
DeToledo
A
A
Minagar
M R
MR
Lowe
R E
RE
Ramsay
D000085:Acetates / Q000009:adverse effects*; D000328:Adult; D000588:Amines; D000927:Anticonvulsants / Q000009:adverse effects*; D003509:Cyclohexanecarboxylic Acids; D004342:Drug Hypersensitivity; D005260:Female; D000077206:Gabapentin; D006801:Humans; D012871:Skin Diseases / Q000139:chemically induced*; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced*; D005680:gamma-Aminobutyric Acid
D000085:Acetates; D000588:Amines; D000927:Anticonvulsants; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin