The porcine hormone-sensitive lipase gene: sequence, structure, polymorphisms and linkage mapping.
The porcine hormone-sensitive lipase gene and its cDNA have been isolated and sequenced. Several putative regulatory sequences have been detected in the promotor region. The deduced amino acid sequence is 85% identical to the corresponding human, mouse and rat sequence. A search for polymorphisms revealed one intronic and one exonic polymorphism, the latter resulting in a conservative amino acid substitution. Linkage mapping located the LIPE gene close to the calcium release channel (CRC) locus on chromosome 6.
Harbitz
I
I
Department of Biochemistry, Physiology and Nutrition, Norwegian School of Veterinary Science, Oslo, Norway.
Langset
M
M
Ege
A G
AG
Høyheim
B
B
Davies
W
W
D000595:Amino Acid Sequence; D000818:Animals; D002874:Chromosome Mapping / Q000662:veterinary*; D018076:DNA, Complementary / Q000737:chemistry / Q000302:isolation & purification; D015971:Gene Expression Regulation, Enzymologic; D015723:Gene Library; D014644:Genetic Variation; D006801:Humans; D007438:Introns; D051379:Mice; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D051381:Rats; D015183:Restriction Mapping / Q000662:veterinary; D016415:Sequence Alignment / Q000662:veterinary; D002787:Sterol Esterase / Q000235:genetics*; D013552:Swine
D018076:DNA, Complementary; D002787:Sterol Esterase