Designed membrane channels and pores.
Advances in the synthesis and assembly of designed membrane channels and pores include addressable template-assisted synthetic protein (TASP) syntheses of helix bundles, the production of a new class of nanotubes and the ability to purify hetero-oligomeric pores. Channels and pores with altered functional properties and with built-in triggers and switches have been prepared. Progress in applications has been greatest in sensor technology, where sensor elements based on ligand activation, channel selectivity and channel block have been made. Structural information about natural membrane proteins is emerging to inspire new designs.
Department of Medical Biochemistry and Genetics Texas A&M Health Science Center College Station TX 77843-1114 USA. bayley@medicine.tamu.edu
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D001692:Biological Transport; D015374:Biosensing Techniques; D015195:Drug Design; D005544:Forecasting; D007473:Ion Channels / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D008051:Lipid Bilayers; D015202:Protein Engineering; D011994:Recombinant Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
D007473:Ion Channels; D008051:Lipid Bilayers; D011994:Recombinant Proteins