Lactic acid polymers as biodegradable carriers of fluoroquinolones: an in vitro study.
A biodegradable polymer of DL-dilactide that facilitates release of ciprofloxacin or pefloxacin at levels exceeding MICs for the causative microorganisms of chronic osteomyelitis is described. Duration and peak of release were found to depend on the molecular weight of the polymer. Its characteristics make it promising for treating chronic bone infections.
Fourth Department of Internal Medicine, Athens Medical School, Sismanoglion General Hospital, Greece.
K
K
Kanellakopoulou
M
M
Kolia
A
A
Anastassiadis
T
T
Korakis
E J
EJ
Giamarellos-Bourboulis
A
A
Andreopoulos
E
E
Dounis
H
H
Giamarellou
D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000737:chemistry*; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000737:chemistry; D004146:Dioxanes / Q000737:chemistry; D004337:Drug Carriers; D019344:Lactic Acid / Q000737:chemistry; D008970:Molecular Weight; D015366:Pefloxacin / Q000008:administration & dosage / Q000737:chemistry; D011091:Polyesters; D011108:Polymers / Q000737:chemistry; D012995:Solubility
D000890:Anti-Infective Agents; D004146:Dioxanes; D004337:Drug Carriers; D011091:Polyesters; D011108:Polymers; D015366:Pefloxacin; D019344:Lactic Acid; C033616:poly(lactide); D002939:Ciprofloxacin; C091880:dilactide