Structural parameters involved in the permeation of propranolol HCl by iontophoresis and enhancers.
The purpose of this work was to study the effect of iontophoretic transport of Propranolol hydrochloride on the lipidic organization of the stratum corneum pretreated under passive or iontophoretic conditions by two model penetration enhancers, sodium lauryl sulfate and hexadecyl trimethylammonium bromide. Characterization of human stratum corneum was performed by X-ray diffraction, attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy and differential scanning calorimetry (DSC). The structural properties were compared with the iontophoretic permeability of propranolol hydrochloride on human stratum corneum. The iontophoretic fluxes of propranolol hydrochloride were effectively increased by two-fold in stratum corneum pretreated with sodium lauryl sulfate. In contrast, they were halved in stratum corneum pretreated with hexadecyl trimethylammonium bromide. These results could be related to changes in the electrical and structural properties of the stratum corneum after incorporation of these enhancers.
URA CNRS 1218, Laboratoire de Pharmacotechnie et Biopharmacie, Université Paris Sud, Châtenay-Malabry, France. chesnoy@phypha.u-psud.fr
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Chesnoy
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Durand
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Doucet
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Couarraze
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000328:Adult; D002152:Calorimetry, Differential Scanning; D005079:Excipients; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007478:Iontophoresis; D011433:Propranolol / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012869:Skin Absorption; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
D000319:Adrenergic beta-Antagonists; D005079:Excipients; D011433:Propranolol