Extractable free monomers from self-cured dental sealants resulting from dispensing errors.
High performance liquid chromatography (HPLC) experiments were performed on a series of commercially available self-curing dental sealant materials that were deliberately mismixed. The goal of the experiments was to measure the amount of extractable sealant under conditions of nonideal processing as might happen clinically. The stoichiometry of the two component resins ranged from a 2/1 to a 1/2 catalyst to base mixture using a commercially available self-cure sealant that was to be mixed 1/1 based on the manufacturer's recommendations. Following fabrication the samples were immersed in an ethanol/water mixture as an extraction fluid that was then analyzed using HPLC. Values other than the 1-1 stoichiometry led to a statistically larger extractable content of bis-glycidyl methacrylate relative to the control. The extractable fraction of triethylene glycol dimethacrylate also increased with mismixing, although statistical differences varied somewhat more. Given the increased concerns about the effects of extractable monomers on the endocrine system, there may be an increased need to maintain proper stoichiometry in a clinical setting.
Department of Materials Science and Engineering, Center for Adhesive and Sealant Science, Virginia Polytechnic Institute and State University, Blacksburg, USA.
V M
VM
Vaubert
P C
PC
Moon
B J
BJ
Love
D017438:Bisphenol A-Glycidyl Methacrylate / Q000032:analysis* / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006801:Humans; D010895:Pit and Fissure Sealants / Q000737:chemistry* / Q000493:pharmacokinetics; D012116:Resins, Plant / Q000737:chemistry* / Q000493:pharmacokinetics; D012651:Self Medication
D010895:Pit and Fissure Sealants; D012116:Resins, Plant; D017438:Bisphenol A-Glycidyl Methacrylate