Stability of captopril in invert sugar solution.
OBJECTIVE
To assess the stability of captopril in different concentrations of invert sugar solution and to verify the hypothesis that the antioxidant effect of invert sugar can inhibit captopril's oxidative degradation.


METHODS
Captopril 1 mg/ml formulations were prepared in 0% (Milli-Q water), 1%, 10%, 30% and 85% w/v of invert sugar and stored at 5 C. The formulations were sampled at intervals up to 30 days for assay of captopril using a stability-indicating high-performance liquid chromatographic method.


RESULTS
Captopril in formulations containing low concentrations (1%, 10%, 30% w/v) of invert sugar was significantly less stable than in the control formulation (captopril 1 mg/ml in Milli-Q water). In contrast, captopril in a formulation containing 85% w/v invert sugar was substantially more stable than in the control.


CONCLUSIONS
Captopril formulated in a solution of 85% w/v invert sugar is stable for at least 2 weeks when stored at 5 degrees C.
Sam
W J
WJ
Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore.
Ho
P C
PC
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000737:chemistry; D002216:Captopril / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004355:Drug Stability; D005632:Fructose / Q000737:chemistry*; D005947:Glucose / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D019216:Metals, Heavy / Q000737:chemistry
D000806:Angiotensin-Converting Enzyme Inhibitors; D019216:Metals, Heavy; D005632:Fructose; D002216:Captopril; C008133:invert sugar; D005947:Glucose