Phagocytosis and development: back to the future.
Removal of apoptotic cells and micro-organisms is mediated via phagocytosis. Phagocytes express pattern-recognition receptors (PRRs) that recognize apoptotic-cell-associated membrane patterns (ACAMPs). Similar ACAMPs and PRRs are used by mammals, Caenorhabditis elegans and Drosophila melanogaster. Some PRRs recognize apoptotic cells and micro-organisms, suggesting overlap between these functions.
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Laboratory of Developmental Immunology and Cutaneous Biology Research Center, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
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Ezekowitz
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D000818:Animals; D017173:Caenorhabditis elegans / Q000276:immunology; D004331:Drosophila melanogaster / Q000276:immunology; D006801:Humans; D008264:Macrophages / Q000276:immunology / Q000378:metabolism; D008322:Mammals / Q000254:growth & development / Q000276:immunology; D010587:Phagocytosis / Q000276:immunology*; D011971:Receptors, Immunologic
D011971:Receptors, Immunologic