[Non-Hodgkin lymphoma in adults. Protein profile of CSF and serum in 25 patients].
Twenty-five non-Hodgkin's adult patients of a cohort studied for detection of neurologic involvement were evaluated on the cerebrospinal fluid (CSF) protein profile. CSF and serum were collected in the same occasion. Blood-brain barrier and local synthesis of IgG were studied. There was an incidence of neurologic signs and symptoms in 48% of all patients. Samples analysis showed: increase of total protein in CSF in 52%; local synthesis of IgG in one HIV seropositive patient; IgG concentration increase in the CSF in the absence of malignant cells in the CSF in two patients that clinically improved after chemotherapy; oligoclonal bands only in the CSF in one HTLV-I seropositive patient. These data show that the study of CSF protein profile can contribute in the characterization of CNS involvement in non-Hodgkin lymphoma.
Centro de Investigações em Neurologia (LIM 15), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC/FMUSP), Brasil.
S R
SR
Mielli
B
B
Beitler
C
C
Galperin
V B
VB
Palou
J A
JA
Livramento
L dos R
Ldos R
Machado
H R
HR
Gomes
D000328:Adult; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000134:cerebrospinal fluid* / Q000150:complications; D009391:Nephelometry and Turbidimetry; D012709:Serum Albumin / Q000032:analysis*
D002556:Cerebrospinal Fluid Proteins; D007074:Immunoglobulin G; D012709:Serum Albumin