The porcine hormone-sensitive lipase gene: sequence, structure, polymorphisms and linkage mapping.
The porcine hormone-sensitive lipase gene and its cDNA have been isolated and sequenced. Several putative regulatory sequences have been detected in the promotor region. The deduced amino acid sequence is 85% identical to the corresponding human, mouse and rat sequence. A search for polymorphisms revealed one intronic and one exonic polymorphism, the latter resulting in a conservative amino acid substitution. Linkage mapping located the LIPE gene close to the calcium release channel (CRC) locus on chromosome 6.
Department of Biochemistry, Physiology and Nutrition, Norwegian School of Veterinary Science, Oslo, Norway.
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Harbitz
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Langset
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Ege
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Høyheim
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Davies
D000595:Amino Acid Sequence; D000818:Animals; D002874:Chromosome Mapping / Q000662:veterinary*; D018076:DNA, Complementary / Q000737:chemistry / Q000302:isolation & purification; D015971:Gene Expression Regulation, Enzymologic; D015723:Gene Library; D014644:Genetic Variation; D006801:Humans; D007438:Introns; D051379:Mice; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D051381:Rats; D015183:Restriction Mapping / Q000662:veterinary; D016415:Sequence Alignment / Q000662:veterinary; D002787:Sterol Esterase / Q000235:genetics*; D013552:Swine
D018076:DNA, Complementary; D002787:Sterol Esterase