Phencyclidine- and diazepam-like discriminative stimulus effects of inhalants in mice.
It has been shown that abused solvents, such as 1,1,1-trichloroethane (TCE) and toluene, share certain pharmacological properties with central nervous system depressants, such as alcohol and anesthetic vapors. Several vapors were tested for diazepam (DZ)- and phencyclidine (PCP)-like discriminative stimulus effects to further explore their pharmacological specificity. In DZ-trained mice, methoxyflurane fully substituted, and TCE produced partial substitution. Fluorothyl and toluene produced no appreciable DZ-lever responding at any concentration tested. On the other hand, toluene produced concentration-related partial substitution for PCP, whereas methoxyflurane, TCE, and fluorothyl did not substitute. The substitution of some these vapors for DZ or PCP suggests that, like ethanol, the discriminative stimulus effects of abused solvents partially overlap those of N-methyl-D-aspartate antagonists as well as those of gamma amino butyric acid agonists.
Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA. sbowen@sun.science.wayne.edu
S E
SE
Bowen
J L
JL
Wiley
H E
HE
Jones
R L
RL
Balster
D000818:Animals; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects; D003975:Diazepam / Q000627:therapeutic use*; D004192:Discrimination, Psychological / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D018691:Excitatory Amino Acid Antagonists / Q000627:therapeutic use*; D018755:GABA Agonists / Q000494:pharmacology; D005793:Generalization, Psychological / Q000187:drug effects; D019570:Inhalation Exposure; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D016202:N-Methylaspartate / Q000037:antagonists & inhibitors; D010622:Phencyclidine / Q000627:therapeutic use*; D012997:Solvents / Q000008:administration & dosage; D019966:Substance-Related Disorders / Q000523:psychology*
D014151:Anti-Anxiety Agents; D018691:Excitatory Amino Acid Antagonists; D018755:GABA Agonists; D012997:Solvents; D016202:N-Methylaspartate; D010622:Phencyclidine; D003975:Diazepam