Envisioning the molecular choreography of DNA base excision repair.
Recent breakthroughs integrate individual DNA repair enzyme structures, biochemistry and biology to outline the structural cell biology of the DNA base excision repair pathways that are essential to genome integrity. Thus, we are starting to envision how the actions, movements, steps, partners and timing of DNA repair enzymes, which together define their molecular choreography, are elegantly controlled by both the nature of the DNA damage and the structural chemistry of the participating enzymes and the DNA double helix.
Parikh
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The Skaggs Institute for Chemical Biology, The Scripps Research Institute, Molecular Biology MB4, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
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Hosfield
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D020137:Base Pair Mismatch; D019757:Carbon-Oxygen Lyases / Q000737:chemistry / Q000378:metabolism; D045647:DNA Glycosylases; D011088:DNA Ligases / Q000737:chemistry* / Q000378:metabolism*; D019951:DNA Polymerase beta / Q000737:chemistry / Q000378:metabolism; D004260:DNA Repair / Q000502:physiology*; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase; D043223:Deoxyribonuclease IV (Phage T4-Induced); D004706:Endodeoxyribonucleases / Q000737:chemistry / Q000378:metabolism; D045585:Flap Endonucleases; D006801:Humans; D008958:Models, Molecular; D009699:N-Glycosyl Hydrolases / Q000737:chemistry / Q000378:metabolism; D011487:Protein Conformation; D044502:Thymine DNA Glycosylase; D051981:Uracil-DNA Glycosidase
D019951:DNA Polymerase beta; D004706:Endodeoxyribonucleases; D045585:Flap Endonucleases; C468317:FEN1 protein, human; D043223:Deoxyribonuclease IV (Phage T4-Induced); D045647:DNA Glycosylases; D009699:N-Glycosyl Hydrolases; D044502:Thymine DNA Glycosylase; D051981:Uracil-DNA Glycosidase; C113921:mismatch-specific thymine uracil-DNA glycosylase; C061738:mutY adenine glycosylase; D019757:Carbon-Oxygen Lyases; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase; D011088:DNA Ligases