Detection of intermolecular chemical exchange through decorrelation of two-spin order.
An initial correlation between two spins is lost when they are separated by intermolecular chemical exchange. This effect, termed "decorrelation by chemical exchange," manifests itself in a decay of the corresponding two-spin modes. It can be used for monitoring intermolecular chemical exchange, as is demonstrated for l-tryptophan where the decay of 1H15N two-spin order provides information on the exchange of indole protons with solvent water.
Laboratorium für Physikalische Chemie, ETH Zentrum, Zürich, 8092, Switzerland.
N R
NR
Skrynnikov
R R
RR
Ernst
D000577:Amides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008962:Models, Theoretical; D015394:Molecular Structure; D009587:Nitrogen Isotopes / Q000032:analysis; D011506:Proteins / Q000737:chemistry; D011522:Protons; D013113:Spin Labels; D014364:Tryptophan / Q000737:chemistry*
D000577:Amides; D009587:Nitrogen Isotopes; D011506:Proteins; D011522:Protons; D013113:Spin Labels; D014364:Tryptophan