Streptococcal invasion.
The genus Streptococcus consists of large number of species many of which are pathogenic to humans and animals. Although streptococci have long been considered as extracellular pathogens, they are capable of causing serious invasive infections such as necrotizing fasciitis and meningitis. Streptococcal invasion, therefore, has been a focus of many studies in recent years. Streptococci are efficiently internalized by nonprofessional phagocytes and the current research interest has shifted to determine the role of this invasion in the natural infection process. Moreover, characterization of bacterial and eukaryotic components involved in the uptake process might be useful in developing new strategies for combating streptococcal infections.
Molinari
G
G
Department of Microbial Pathogenesis and Vaccine Research Technical University/GBF-National Research Centre for Biotechnology Spielmann Str 7 38106 Braunschweig Germany.
Chhatwal
G S
GS
D018829:Adhesins, Bacterial / Q000378:metabolism; D000818:Animals; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins / Q000378:metabolism; D001426:Bacterial Proteins / Q000378:metabolism*; D002237:Carbohydrate Dehydrogenases / Q000378:metabolism; D002352:Carrier Proteins; D002460:Cell Line; D064211:Connectin; D004268:DNA-Binding Proteins / Q000378:metabolism; D005098:Exotoxins / Q000378:metabolism; D019922:GAP-43 Protein / Q000378:metabolism; D006367:HeLa Cells; D006360:Heat-Shock Proteins / Q000378:metabolism; D006460:Hemolysin Proteins / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins; D009124:Muscle Proteins; D009194:Myeloma Proteins; D019158:N-Acetylneuraminic Acid / Q000378:metabolism; D013291:Streptococcus / Q000737:chemistry / Q000201:enzymology / Q000472:pathogenicity*; D014774:Virulence
D018829:Adhesins, Bacterial; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D002352:Carrier Proteins; C490083:CbpA protein, bacteria; D064211:Connectin; D004268:DNA-Binding Proteins; D005098:Exotoxins; D019922:GAP-43 Protein; D006360:Heat-Shock Proteins; D006460:Hemolysin Proteins; D008565:Membrane Proteins; D009124:Muscle Proteins; D009194:Myeloma Proteins; C117980:SpeA protein, Streptococcus pyogenes; C027951:erythrogenic toxin; C085016:multiple myeloma M-proteins; C014689:streptococcal M protein; D002237:Carbohydrate Dehydrogenases; C104557:sorbose dehydrogenase; D019158:N-Acetylneuraminic Acid