[Kimura's disease of the lymph node. Histology, immunohistochemistry, and differential diagnosis].
Kimura's disease, a chronic inflammatory condition of unknown cause, occurs predominantly in young Asian adult men. The disease involves subcutaneous tissues and lymph nodes in the head and neck region. We report a new case occurring in a young woman. The diagnosis was made late on a retroauricular lymph node examination. Immunohistochemical study showed that B lymphoid area remained, located in the germinal center showing some fibrosis involvement, and in the subcortex. T lymphoid zones were observed in the paracortex. Strong IgE positivity was noted in germinal centers. Vessels were positive with CD31, CD34, factor VIII and smooth muscle actin antibodies. Warthin-Finkeldey cells were negative for lymphoid and macrophagic markers used in this study. Differential diagnosis is discussed.
Battaglione
V
V
Service d'Anatomie Pathologique, Hôpital Pasteur, Nice.
le Tourneau
A
A
Soler
C
C
Deville
A
A
Michiels
J F
JF
Hofman
P
P
D000199:Actins / Q000032:analysis; D000328:Adult; D000796:Angiolymphoid Hyperplasia with Eosinophilia / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D018952:Antigens, CD34 / Q000032:analysis; D001402:B-Lymphocytes / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology; D003937:Diagnosis, Differential; D005169:Factor VIII / Q000032:analysis; D005260:Female; D005355:Fibrosis; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008526:Medulla Oblongata / Q000473:pathology; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000032:analysis
D000199:Actins; D018952:Antigens, CD34; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D005169:Factor VIII