Effectiveness of 1,25-dihydroxyvitamin D supplementation on blood pressure reduction in a pseudohypoparathyroidism patient with high renin activity.
A 42-year-old man had biochemical and somatic abnormalities compatible with pseudohypoparathyroidism type I (PsHP) and also had high plasma renin activity (PRA). After 1,25-dihydroxyvitamin D (calcitriol) supplementation the systolic/diastolic blood pressure, assessed by 24-hour non-invasive ambulatory blood pressure monitoring, was reduced from 145/96 mm Hg to 128/85 mm Hg with normalization of the serum calcium level and its related hormones, as well as decreased PRA. Calcitriol supplementation successfully reduced the blood pressure in this patient with PsHP and a high PRA, suggesting that calcium-related hormones and/or the renin-angiotensin system were involved in lowering the blood pressure.
Second Department of Internal Medicine, Iwate Medical University, Morioka.
Y
Y
Kimura
M
M
Kawamura
M
M
Owada
T
T
Oshima
M
M
Murooka
T
T
Fujiwara
K
K
Hiramori
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D018660:Blood Pressure Monitoring, Ambulatory; D002118:Calcium / Q000097:blood; D019587:Dietary Supplements; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011547:Pseudohypoparathyroidism / Q000097:blood / Q000178:diet therapy* / Q000503:physiopathology; D012083:Renin / Q000097:blood*; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000627:therapeutic use
D014807:Vitamin D; C097949:1,25-dihydroxyvitamin D; D012083:Renin; D002118:Calcium