Tyrosine phosphorylated proteins in synovial cells of rheumatoid arthritis.
Two of the key events in the pathogenesis of rheumatoid arthritis are the synovial cell proliferation and lymphocyte infiltration into the synovium. The resulting synovitis is longlasting and leads to destructive arthritis, which is a hallmark of rheumatoid arthritis. Accumulating evidence suggests that one of the key biochemical events in the altered cell function of RA is phosphorylation of the tyrosine residues of proteins. In this paper we review the cellular components participating in the chronic inflammation of RA joints. We present the results of analyzing tyrosine phosphorylated proteins of synovial cells from RA patients and discuss a possible pathogenic role of non-receptor tyrosine kinase in RA.
Second Department of Internal Medicine, Saitama Medical Center, Saitama Medical School, Japan. tsutake@saitama-med.ac.jp
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Takeuchi
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Abe
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000502:physiology; D016207:Cytokines / Q000276:immunology; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; D006133:Growth Substances / Q000276:immunology; D006801:Humans; D016023:Integrins / Q000276:immunology; D008024:Ligands; D010766:Phosphorylation; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D011506:Proteins / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction / Q000276:immunology; D013583:Synovial Membrane / Q000166:cytology; D014443:Tyrosine / Q000378:metabolism*
D015815:Cell Adhesion Molecules; D016207:Cytokines; D006133:Growth Substances; D016023:Integrins; D008024:Ligands; D011506:Proteins; D014443:Tyrosine; D011505:Protein-Tyrosine Kinases; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; C496050:PTK2 protein, human