Increased serum concentrations of carbohydrate-deficient transferrin (CDT) in patients with cystic fibrosis.
Carbohydrate-deficient transferrin (CDT) has been reported to be one of the best laboratory markers in serum (S) for detection of alcohol abuse. We have studied S-CDT values in cystic fibrosis (CF) patients and show that CF patients have increased S-CDT values without high alcohol consumption. CF patients have abnormalities in their protein glycosylation and sialylation, which may explain the increased S-CDT values.
Department of Clinical Chemistry, University Hospital, Uppsala, Sweden.
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A
Larsson
M
M
Flodin
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H
Kollberg
D000293:Adolescent; D000328:Adult; D002648:Child; D002852:Chromatography, Ion Exchange; D003550:Cystic Fibrosis / Q000097:blood / Q000201:enzymology*; D005260:Female; D006801:Humans; D007118:Immunoassay; D007527:Isoenzymes / Q000097:blood; D008297:Male; D014168:Transferrin / Q000031:analogs & derivatives* / Q000032:analysis
D007527:Isoenzymes; D014168:Transferrin; C056759:carbohydrate-deficient transferrin