Heterogeneity of phenotypic and genotypic traits including organic-acid resistance in Escherichia coli O157 isolates.
We undertook an epidemiologic study for the sensitivity of both Shiga-like toxin (Slt)-producing Escherichia coli (STEC) O157 and non-STEC O157 strains isolated from different patients with diarrhea to hydrochloric acid (HCl) and organic acids such as acetate, propionate, butyrate and lactate, and other pathogenic factors. The E. coli O157 isolates examined showed a wide variety of organic-acid susceptibility patterns. E. coli O157 isolates resistant to HCl or acetate were found more frequently than those resistant to other organic acids. These isolates also showed diverse pathogenicity patterns for the presence of the virulence genes, antibiotic susceptibility and plasmid profile.
Department of Bacteriology, Nagoya University School of Medicine, Aichi, Japan.
T
T
Horii
S
S
Barua
T
T
Kimura
S
S
Kasugai
K
K
Sato
K
K
Shibayama
S
S
Ichiyama
M
M
Ohta
D000144:Acids, Acyclic / Q000494:pharmacology*; D003967:Diarrhea / Q000382:microbiology*; D004352:Drug Resistance, Microbial / Q000235:genetics; D019453:Escherichia coli O157 / Q000187:drug effects* / Q000235:genetics; D018740:Genetic Heterogeneity; D005838:Genotype; D006801:Humans; D006851:Hydrochloric Acid / Q000494:pharmacology*; D007773:Lactates / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010641:Phenotype
D000144:Acids, Acyclic; D007773:Lactates; D006851:Hydrochloric Acid