[History of the treatment of Helicobacter pylori and clinical efficacy].
The combination of a proton pump inhibitor with antibiotics has been accepted as an effective treatment for the eradication of Helicobacter pylori and the most rational regimen to cure peptic ulcers. Triple therapies including two antibiotics and a proton pump inhibitor achieves constant and high eradication rate. The one-week, low-dose triple regimen including metronidazole has been accepted in European countries, but the new triple therapy with proton pump inhibitor, amoxicillin and clarithromycin is recommended for treatment of H. pylori infection in Japan. Quadruple therapy with two antibiotics, bismuth and a proton pump inhibitor is a second-line therapy. Triple therapy with ranitidine bismuth and two antibiotics may be promising.
Yamamoto Clinic, Hyogo College of Medicine.
I
I
Yamamoto
Y
Y
Fukuda
T
T
Shimoyama
D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D001729:Bismuth / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D009853:Omeprazole / Q000627:therapeutic use; D010437:Peptic Ulcer / Q000188:drug therapy / Q000382:microbiology; D017410:Practice Guidelines as Topic; D054328:Proton Pump Inhibitors
D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D054328:Proton Pump Inhibitors; D009853:Omeprazole; D001729:Bismuth