[The use of cryopreserved hepatocytes in the combined treatment of patients with acute liver failure].
Shown in the paper is employment of one of the modern modalities of treatment of acute hepatic insufficiency (AHI)--that of "cell dialysis" involving the use of freeze-preserved hepatocytes. Hepatic insufficiency develops as a result of poisoning with hepatotrophic poisons (chlorinated hydrocarbons, poisonous mushrooms). The principle of commonly practised hemodialysis is the basis of "cell dialysis" but it was hepatocytes mixture in Hank's solution that was used as a dialysis solution. The time-related course was studied of clinical, laboratory findings. The inclusion of "cell dialysis" into the complex of active methods of detoxication was found to bring about an appreciable decline in mortality among AHI patients together with a reduction of their hospital stay.
Lebedeva
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Kebkalo
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D003131:Combined Modality Therapy; D015925:Cryopreservation; D005069:Evaluation Studies as Topic; D006501:Hepatic Encephalopathy / Q000097:blood / Q000209:etiology / Q000628:therapy; D006801:Humans; D008099:Liver / Q000166:cytology*; D017114:Liver Failure, Acute / Q000097:blood / Q000209:etiology / Q000628:therapy*; D011041:Poisoning / Q000097:blood / Q000150:complications / Q000628:therapy; D016060:Sorption Detoxification / Q000379:methods*; D013997:Time Factors; D014021:Tissue Preservation