Combinatorial gene regulation by eukaryotic transcription factors.
Recent structure determinations of high order complexes of eukaryotic transcription factors bound to DNA have revealed that residues from their DNA-binding domains are involved in protein-protein interactions between distinct factors. Protein-protein interactions between transactivation domains and coactivators have also been characterized in a number of recently determined structures. These studies support the combinatorial mechanism of transcription regulation in eukaryotic cells and multicellular organisms.
Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO 80309-0215, USA. lchen@xtal200.harvard.edu
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D001665:Binding Sites; D004247:DNA / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D005057:Eukaryotic Cells; D005786:Gene Expression Regulation; D046911:Macromolecular Substances; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D011487:Protein Conformation; D015534:Trans-Activators / Q000737:chemistry / Q000378:metabolism; D014157:Transcription Factors / Q000737:chemistry* / Q000378:metabolism*
D046911:Macromolecular Substances; D015534:Trans-Activators; D014157:Transcription Factors; D004247:DNA