Ki-1+ large-cell anaplastic lymphoma after Ewing sarcoma.
OBJECTIVE
A large cell anaplastic lymphoma that developed after treatment of a Ewing sarcoma (ES) is described.


METHODS
An 11-year-old girl with a pelvic ES developed a large cell, Ki-1+, anaplastic lymphoma in the same anatomic location 10 months after multimodal therapy.


RESULTS
ES recurred in the primary site 16 months after allogeneic marrow transplantation and 3.5 years after initial diagnosis, but the patient remains in remission from her lymphoma.


CONCLUSIONS
The occurrence of lymphoma and ES in a short time interval in the same patient is very unusual. Whether etiologic factors other than chemoradiotherapy, including genetic disposition, play a role remains to be elucidated.
Division of Pediatric Hematology/Oncology, All Children's Hospital, St. Petersburg, Florida, USA.
H C
HC
Rossbach
W
W
Chamizo
A K
AK
Walling
N H
NH
Grana
K
K
Washington
J L
JL
Barbosa
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D002648:Child; D005260:Female; D006801:Humans; D017728:Lymphoma, Large-Cell, Anaplastic / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000473:pathology*; D012512:Sarcoma, Ewing / Q000150:complications / Q000188:drug therapy / Q000473:pathology*