Biliary bacterial infection decreased the secretion of bile acids and bilirubin into bile.
BACKGROUND
Bacterial cholangitis is frequently associated with serious complications.


METHODS
The plasma disappearance rates and the biliary output of bile acids and bilirubin after percutaneous transhepatic biliary drainage (PTBD) were examined in 29 patients with extrahepatic biliary obstruction.


RESULTS
Twenty-nine patients were divided into the bacteria-minus (n = 17) and bacteria-plus (n = 12) groups. Decreases in the plasma bile acid and bilirubin levels of the bacteria-minus group (t1/2 = 0.38 and 3.8 days for bile acids and bilirubin, respectively) were faster than those of the bacteria-plus group (t1/2 = 1.7 and 7.5 days). The bile flow rate was significantly increased in the bacteria-plus group compared with the bacteria-minus group. The calculated values of bilirubin and bile acid in the bile were higher in the bacteria-minus group than in the bacteria-plus group.


CONCLUSIONS
Bacterial colonization in the bile stimulates bile duct cells to increase bile volume and inhibits the hepatocyte transport activity of bile acids and bilirubin.
First Department of Surgery, Osaka University Medical School, Osaka Police Hospital, Suita, Japan.
T
T
Nishida
M
M
Nakahara
K
K
Nakao
H
H
Matsuda
D000368:Aged; D001424:Bacterial Infections / Q000097:blood / Q000175:diagnosis* / Q000628:therapy; D001646:Bile / Q000378:metabolism* / Q000382:microbiology; D001647:Bile Acids and Salts / Q000097:blood*; D001663:Bilirubin / Q000097:blood*; D002761:Cholangitis / Q000097:blood / Q000175:diagnosis* / Q000628:therapy; D001651:Cholestasis, Extrahepatic / Q000097:blood / Q000175:diagnosis / Q000628:therapy; D004322:Drainage; D005260:Female; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged
D001647:Bile Acids and Salts; D001663:Bilirubin