Parathyroid hormone-related protein (PTH-rP)-associated hypercalcemia in a patient with an atypical chronic lymphocytic leukemia.
We describe a patient with an atypical chronic lymphocytic leukemia (CLL) of the mixed cell type with a hypercalcemia due to parathyroid hormone-related protein production by the malignant B cells. On regard of the elevated serum calcium level without overt lytic bone lesions we found elevated serum levels of PTH-rP and demonstrated the presence of PTH-rP on the malignant lymphocytes. PTH-rP-related hypercalcemia in CLL is very rare. The role in PTH-rP in humoral hypercalcemia of malignancy is discussed.
Department of Internal Medicine, Diaconessenhuis, BM Eindhoven, The Netherlands.
L T
LT
Vlasveld
P
P
Pauwels
A A
AA
Ermens
W H
WH
Aarnoudse
H W
HW
Ooms
H R
HR
Haak
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000008:administration & dosage; D017809:Fatal Outcome; D006801:Humans; D006934:Hypercalcemia / Q000097:blood* / Q000209:etiology*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood*; D044162:Parathyroid Hormone-Related Protein; D010446:Peptide Fragments / Q000097:blood*; D011241:Prednisone / Q000008:administration & dosage; D011506:Proteins; D018805:Sepsis; D014750:Vincristine / Q000008:administration & dosage
C470121:PTHLH protein, human; D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein; D010446:Peptide Fragments; D011506:Proteins; C071784:parathyroid hormone-related protein (107-111); D014750:Vincristine; D003520:Cyclophosphamide; D011241:Prednisone