Molecular mechanisms of nonmuscle myosin-II regulation.
Myosin II, the conventional two-headed myosin that forms bipolar filaments, is directly involved in regulating cytokinesis, cell motility and cell morphology in nonmuscle cells. To understand the mechanisms by which nonmuscle myosin-II regulates these processes, investigators are now looking at the regulation of this molecule in vertebrate nonmuscle cells. The identification of multiple isoforms of nonmuscle myosin-II, whose activities and regulation differ from that of smooth muscle myosin-II, suggests that, in addition to regulatory light chain phosphorylation, other regulatory mechanisms control vertebrate nonmuscle myosin-II activity.
Department of Biochemistry Albert Einstein College of Medicine 1300 Morris Park Avenue Bronx NY 10461 USA. bresnick@aecom.yu.edu
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Bresnick
D000818:Animals; D001483:Base Sequence; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics; D006801:Humans; D019476:Insect Proteins / Q000378:metabolism; D007700:Kinetics; D008969:Molecular Sequence Data; D009218:Myosins / Q000737:chemistry / Q000378:metabolism*; D010766:Phosphorylation; D020033:Protein Isoforms; D011493:Protein Kinase C / Q000378:metabolism; D000071999:S100 Calcium-Binding Protein A4; D009418:S100 Proteins / Q000378:metabolism; D013329:Structure-Activity Relationship; D025521:Tumor Suppressor Proteins
D029721:Drosophila Proteins; D019476:Insect Proteins; D020033:Protein Isoforms; D000071999:S100 Calcium-Binding Protein A4; D009418:S100 Proteins; D025521:Tumor Suppressor Proteins; C081435:l(2)gl protein, Drosophila; C077591:S100A4 protein, human; D011493:Protein Kinase C; D009218:Myosins