Lung surfactant proteins involved in innate immunity.
The two lung surfactant collectins, surfactant protein (SP)-A and SP-D, are involved in host defence against infectious and allergenic agents via enhancement of killing and clearance by macrophages and neutrophils. Recent gene-knockout, protein engineering and physiological studies have emphasised the roles that SP-A and SP-D play in acute inflammatory responses.
MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, UK. eggleton@bioch.ox.ac.uk.
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D000818:Animals; D006023:Glycoproteins / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D008168:Lung / Q000737:chemistry / Q000276:immunology; D011510:Proteolipids / Q000276:immunology; D037662:Pulmonary Surfactant-Associated Protein A; D037663:Pulmonary Surfactant-Associated Protein D; D037661:Pulmonary Surfactant-Associated Proteins; D011663:Pulmonary Surfactants / Q000276:immunology*
D006023:Glycoproteins; D011510:Proteolipids; D037662:Pulmonary Surfactant-Associated Protein A; D037663:Pulmonary Surfactant-Associated Protein D; D037661:Pulmonary Surfactant-Associated Proteins; D011663:Pulmonary Surfactants