Amorphous no longer: the centrosome comes into focus.
Recent genetic and biochemical studies have provided new insights into the molecular basis of centrosome-mediated microtubule nucleation. In addition, molecules and mechanisms involved in microtubule severing and stabilization at the centrosome, assembly of proteins onto centrosomes and regulation of centrosome duplication and separation are being defined. Characterization of centrosome function, together with studies implicating centrosomes in tumorigenesis and demonstrating that centrosomes are highly organized, are beginning to bring into focus an organelle once viewed as an 'amorphous cloud'.
Zimmerman
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Program in Molecular Medicine 373 Plantation Street University of Massachusetts Medical Center Worcester MA 01605 USA.
Sparks
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CA
Doxsey
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SJ
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D018385:Centrosome / Q000502:physiology*; D008870:Microtubules / Q000502:physiology*; D008938:Mitosis / Q000502:physiology; D008954:Models, Biological; D009369:Neoplasms / Q000648:ultrastructure; D014404:Tubulin / Q000378:metabolism
D014404:Tubulin