What the actions of anaesthetics on fast synaptic transmission reveal about the molecular mechanism of anaesthesia.
1. Synapses with the brain are important components of the networks responsible for higher nervous function and current evidence suggests that general anaesthetics modulate synaptic transmission in the brain. 2. Analysis of anaesthetic action on these synapses not only defines the cellular mechanisms involved in anaesthesia but also reveals much about the molecular targets of anaesthetic action. 3. It appears that while anaesthetics affect a wide variety of processes, the most sensitive are those which are directly linked to the activity of ligand-gated ion channels. Moreover, both single channel patch clamp studies and the molecular biological investigations of the sub-unit specificity of the sensitivity to anaesthetics indicate that anaesthetics interact directly with these functional proteins.
Department of Physiology, Royal Free Hospital School of Medicine, London, UK. richards@rfhsm.ac.uk
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Richards
D000768:Anesthesia, General; D018681:Anesthetics, General / Q000494:pharmacology*; D000818:Animals; D006801:Humans; D009435:Synaptic Transmission / Q000187:drug effects*
D018681:Anesthetics, General