[Comparative studies on immunogenicity of Chinese hamster ovary cell drived HB vaccine and plasma drived HB vaccine].
Chinese Hamster Ovary cell drived HB vaccine (CDV) and plasma drived HB vaccine (PDV) were separately given to two groups of 113 and 112 medical staff subjected, and the anti-HBs responses were observed for five years from the initial injection. The anti-HBs positive rate at 7 months was 96.9% (mean geometric anti-HBs concentration 588 IU/L) in CDV group and 77.8% (83 IU/L) in PDV group, and the positive rate and mean titer of anti-HBs were always higher for 5 years in CDV group. Those differences were remarkable in the subjects aged over 40 years. The decreasing curves of anti-HBs titer in the two groups were parallel from 7th. month to 60th. month. Thus, the protective efficacy was estimated to be far longer in CDV than PDV. Also, the rate of non-responder was less lower in CDV group (2.8%) than PDV group (15.2%). Above results show that CDV has a higher immunogenicity than PDV.
Department of Gastroenterology, Tokyo National Hospital.
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Yagura
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Kamitsukasa
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Harada
D000818:Animals; D006224:Cricetinae; D003412:Cricetulus; D005260:Female; D006509:Hepatitis B / Q000276:immunology*; D006510:Hepatitis B Antibodies / Q000032:analysis; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006801:Humans; D008297:Male; D010053:Ovary / Q000166:cytology; D010950:Plasma Cells; D014614:Vaccines, Synthetic / Q000276:immunology*
D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines; D014614:Vaccines, Synthetic