Experimental studies (in vitro) on polyene macrolide antibiotics with special reference to hamycin against Malassezia ovale.
Hamycin activity (in vitro) against Malassezia ovale was studied and compared with old and newly discovered polyene antifungal antibiotics. Hamycin showed a marked anti-M. ovale activity which was enhanced in the presence of divalent cations like Cu++ and Zn++. Furthermore, the absorption of hamycin onto the cell membrane or cell surface of M. ovale was also increased in the presence of divalent cations. It is suggested that hamycin alone or along with metal ions, specifically Cu++ may be useful clinically in the treatment of dandruff or seborrheic dermatitis.
Gupte
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TE
Laboratory of Industrial Microbiology and Fermentation, Antibiotics Research Centre, Hindustan Antibiotics Limited, Pimpri, Pune, India.
Gaikwad
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UV
Naik
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SR
D000666:Amphotericin B / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use; D019327:Copper Sulfate / Q000494:pharmacology; D012628:Dermatitis, Seborrheic / Q000188:drug therapy; D003881:Dermatomycoses / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D018942:Macrolides; D008290:Malassezia / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D009761:Nystatin / Q000494:pharmacology; D011090:Polyenes / Q000494:pharmacology* / Q000627:therapeutic use; D019287:Zinc Sulfate / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D018942:Macrolides; D011090:Polyenes; C000877:dermostatin; D009761:Nystatin; C100114:hamycin; D019287:Zinc Sulfate; D000666:Amphotericin B; C034048:aureofungin; C033147:JA 20; D019327:Copper Sulfate