Presurgical contribution of quantitative stereotactic positron emission tomography in temporo limbic epilepsy.
BACKGROUND
We quantified the interictal metabolic changes associated with temporal lobe epilepsy by using an accurate stereotactic method.


METHODS
We selected 16 patients who had proven unilateral focal or regional temporal onset defined by SEEG criteria. Each patient underwent stereotactic MRI and stereotactic [18 fluoro] fluorodeoxyglucose positron emission tomography (PET).


RESULTS
Asymmetries (mean, +/- SD) were found in mesio-temporal structures: amygdala (-0.033+/-0.027, p = 0.0002), hippocampus (-0.035+/-0.032, p = 0.0006), and superior temporal gyrus (-0.036+/-0.032, p = 0.0004). Four of the sixteen patients had previously had unlocalized qualitative nonstereotactic PET analysis.


CONCLUSIONS
The quantitative stereotactical PET method allows a higher resolution study of mesio-temporal structures.
Epilepsy and Brain Mapping Program, Cedars-Sinai Medical Office Towers, Los Angeles, California, USA.
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Parker
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Levesque
D000293:Adolescent; D000328:Adult; D001931:Brain Mapping / Q000379:methods*; D004828:Epilepsies, Partial / Q000000981:diagnostic imaging* / Q000601:surgery*; D004833:Epilepsy, Temporal Lobe / Q000000981:diagnostic imaging / Q000601:surgery; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008032:Limbic System / Q000000981:diagnostic imaging / Q000601:surgery; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D019275:Radiopharmaceuticals; D013238:Stereotaxic Techniques; D014055:Tomography, Emission-Computed / Q000379:methods; D016896:Treatment Outcome
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18