[Molecular biology of dengue virus].
In Venezuela the problem of Dengue infection has become worst during the last decade, turning the country into an hyperendemic region where three of the four serotypes co-circulate. The Dengue has become a problem of Public Health, so the knowledge of the virus, its life cycle and characteristics, as well as the different aspects related with its biology are extremely important to fight the virus and for the develop of a vaccine. In a general way, the present work describes different aspects related to the molecular biology of the Dengue virus and its life cycle: the structure, composition, production of structural and non structural protein and its relation to the replication cycle of the virus. Some aspects related with the assembly and release of particles from infected cells are also discussed. With this a general view of the molecular biology of the Dengue virus and its replication in the host cell is shown.
Instituto de Medicina Experimental, Facultad de Medicina, Universidad Central de Venezuela, Caracas, Venezuela. arojas@reacciun.ve
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Rojas Mazzei
D000818:Animals; D003715:Dengue / Q000453:epidemiology / Q000235:genetics; D003716:Dengue Virus / Q000235:genetics*; D004199:Disease Vectors; D005416:Flavivirus / Q000235:genetics; D012367:RNA, Viral; D014764:Viral Proteins; D014774:Virulence / Q000235:genetics; D014779:Virus Replication / Q000235:genetics*
D012367:RNA, Viral; D014764:Viral Proteins