Dioxin is a systemic promoter blocker, II.
The author uses previously unpublished plant worker mortality data, which underlie the 1990 National Institute for Occupational Safety and Health (NIOSH) Report on Dioxin, to identify additional tissue/organ/system sites at which dioxin exposure causes or is associated with a reduction in mortality. These new observations in men include reductions in urinary organ cancers, including bladder cancers; multiple myeloma; respiratory diseases, including emphysema and pneumoconioses and other respiratory diseases; total disease other than cancer; and total disease. Explanations are provided for why some of these reductions, observed in the NIOSH internal plant comparisons, were not noted in Bertazzi and colleagues' R-region men, how men and women differ in their responses to dioxin exposure in common tissues, and how a dioxin complex might interact with the body's DNA to promote-block cancers in one tissue and to promote cancers in that tissue or another.
Kayajanian
G M
GM
1600 South Joyce Street, Suite 1411, Arlington, VA 22202, USA.
D016588:Anticarcinogenic Agents / Q000633:toxicity; D004147:Dioxins / Q000633:toxicity; D005260:Female; D006801:Humans; D008297:Male; D008962:Models, Theoretical; D009101:Multiple Myeloma / Q000401:mortality; D009314:National Institute for Occupational Safety and Health, U.S.; D009369:Neoplasms / Q000401:mortality*; D016273:Occupational Exposure / Q000009:adverse effects; D011401:Promoter Regions, Genetic; D012140:Respiratory Tract Diseases / Q000401:mortality; D014481:United States / Q000453:epidemiology; D014571:Urologic Neoplasms / Q000401:mortality
D016588:Anticarcinogenic Agents; D004147:Dioxins