Simultaneous lactate editing and observation of other metabolites using a stimulated-echo-enhanced double-quantum filter.
Conventional double-quantum editing techniques recover only one metabolite at a time, and are thus inefficient for monitoring metabolic changes involving several metabolites. In this paper, a stimulated-echo-enhanced selective double-quantum coherence transfer (STE-SelDQC) sequence is described, which allows simultaneous observation of lactate and other metabolites in a single scan while leaving fat and water signals suppressed. A frequency selective double-quantum filter designed for lactate editing suppresses fat and water resonances and a stimulated-echo window of adjustable frequency and bandwidth is incorporated into the double-quantum filter for simultaneous observation of other metabolites. The performance of the sequence is demonstrated in phantoms and rat brain tissue.
Lei
H
H
Department of Chemistry, The University of Manitoba, Winnipeg, Manitoba, R3E 0W3, Canada.
Peeling
J
J
D000818:Animals; D001834:Body Water / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D017352:Echo-Planar Imaging / Q000379:methods*; D019344:Lactic Acid / Q000378:metabolism*; D008962:Models, Theoretical; D019047:Phantoms, Imaging; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D019344:Lactic Acid; D005680:gamma-Aminobutyric Acid; D003401:Creatine; D002794:Choline