Prolonged survival of a patient with sickle cell trait and metastatic renal medullary carcinoma.
OBJECTIVE
The treatment and outcome of a patient with sickle cell trait and metastatic renal medullary carcinoma is described.


METHODS
A 12-year-old boy with sickle cell trait had metastatic renal medullary carcinoma. After surgical resection of the primary tumor, he received chemotherapy with methotrexate, vinblastine, doxorubicin, and cisplatin. The carcinoma progressed after a 6-month period of stable disease. At that time, he received chemotherapy including ifosfamide, etoposide, carboplatin, and topotecan.


RESULTS
The patient died of progressive disease 15 months from diagnosis. The patient's tumor in this report showed no progression while he was receiving methotrexate, vinblastine, doxorubicin, and cisplatin, but eventually became refractory to these and other cytotoxic agents.


CONCLUSIONS
Renal medullary carcinoma is a highly chemotherapy-resistant tumor. Average survival after diagnosis is 15 weeks; the longest survival reported in the literature is 12 months from diagnosis. The patient in this report survived longer than the previously described patients before dying from progressive disease.
Pirich
L M
LM
Department of Pediatrics, Northwestern University Medical School, Children's Memorial Hospital, Chicago, Illinois, USA.
Chou
P
P
Walterhouse
D O
DO
D018276:Carcinoma, Medullary / Q000150:complications* / Q000473:pathology; D002648:Child; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D007680:Kidney Neoplasms / Q000150:complications* / Q000473:pathology; D008297:Male; D012805:Sickle Cell Trait / Q000150:complications* / Q000473:pathology