Molecular and cellular biology of pneumococcal infection.
The complete pneumococcal genome sequence was released in November, 1997. This advance has been combined with new understanding of physiology and pathogenesis including characterization of a family of surface proteins adducted to choline, regulation of virulence, and the regulon for natural DNA transformation. These developments in our understanding of molecular and cellular biology of pneumococcal infection will allow the development of new vaccines and antibiotics against this community acquired pathogen.
Tuomanen
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Department of Infectious Diseases St Jude Children's Research Hospital 332 N Lauderdale Rd Memphis TN 38105 USA. elaine.tuomanen@stjude.org
D000818:Animals; D000942:Antigens, Bacterial / Q000235:genetics / Q000276:immunology; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D002794:Choline / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D051379:Mice; D009238:N-Acetylmuramoyl-L-alanine Amidase / Q000235:genetics; D010641:Phenotype; D011008:Pneumococcal Infections / Q000453:epidemiology / Q000382:microbiology*; D013296:Streptococcus pneumoniae / Q000737:chemistry / Q000472:pathogenicity / Q000502:physiology*; D013301:Streptolysins / Q000235:genetics; D014774:Virulence
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C490083:CbpA protein, bacteria; D004268:DNA-Binding Proteins; D006360:Heat-Shock Proteins; D013301:Streptolysins; C032290:plY protein, Streptococcus pneumoniae; C051592:pneumococcal surface protein A; C076332:EJL amidase; D009238:N-Acetylmuramoyl-L-alanine Amidase; D002794:Choline