[Co-infection of HBV with HCV and a possible role of HBV DNA in hepatocarcinogenesis].
HBV and HCV are two major etiologic agents of chronic hepatitis, which is closely related to the development of hepatocellular carcinoma (HCC). A possible involvement of HBV co-infection was investigated in ongoing HCV-related liver diseases in HCV-infected patients. A high prevalence of anti-HBC in anti-HCV-positive/HBsAg-negative chronic hepatitis patients was found and a low copy number of HBV DNA was detected in most of the liver biopsy samples of anti-HCV-positive/HBsAg-negative patients. The current data suggest that HBV co-infects frequently with HCV and may play an important role in the development of HCC in HCV-infected patients.
Koike
K
K
Department of Gene Research, Cancer Institute (JFCR).
D006528:Carcinoma, Hepatocellular / Q000209:etiology* / Q000821:virology; D004279:DNA, Viral / Q000235:genetics; D018628:Gene Dosage; D006508:Hepatitis Antibodies / Q000032:analysis; D006509:Hepatitis B / Q000150:complications* / Q000821:virology; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006515:Hepatitis B virus / Q000235:genetics; D006526:Hepatitis C / Q000150:complications* / Q000821:virology; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology* / Q000821:virology
D004279:DNA, Viral; D006508:Hepatitis Antibodies; D006514:Hepatitis B Surface Antigens