Calcitonin decreases lithium plasma levels in man. Preliminary report.
Lithium kinetics were studied in four manic-depressive women treated with calcitonin for post-menopausal osteoporosis. During calcitonin therapy all patients showed a significant decrease of lithium blood levels, and an increase in lithium renal clearance was observed in two out of two patients. According to these data, lithium therapy needs to be adjusted in patients undergoing concomitant treatment with calcitonin.
Department of Medical Sciences, University of Cagliari, Italy.
G
G
Passiu
A
A
Bocchetta
V
V
Martinelli
P
P
Garau
M
M
Del Zompo
A
A
Mathieu
D000368:Aged; D001714:Bipolar Disorder / Q000188:drug therapy; D002116:Calcitonin / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008094:Lithium / Q000097:blood*; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy
D002116:Calcitonin; D008094:Lithium