Combinatorial gene regulation by eukaryotic transcription factors.
Recent structure determinations of high order complexes of eukaryotic transcription factors bound to DNA have revealed that residues from their DNA-binding domains are involved in protein-protein interactions between distinct factors. Protein-protein interactions between transactivation domains and coactivators have also been characterized in a number of recently determined structures. These studies support the combinatorial mechanism of transcription regulation in eukaryotic cells and multicellular organisms.
Chen
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Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO 80309-0215, USA. lchen@xtal200.harvard.edu
D001665:Binding Sites; D004247:DNA / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D005057:Eukaryotic Cells; D005786:Gene Expression Regulation; D046911:Macromolecular Substances; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D011487:Protein Conformation; D015534:Trans-Activators / Q000737:chemistry / Q000378:metabolism; D014157:Transcription Factors / Q000737:chemistry* / Q000378:metabolism*
D046911:Macromolecular Substances; D015534:Trans-Activators; D014157:Transcription Factors; D004247:DNA