Retinotopic mapping of lateral geniculate nucleus in humans using functional magnetic resonance imaging.
Subcortical nuclei in the thalamus, which play an important role in many functions of the human brain, provide challenging targets for functional mapping with neuroimaging techniques because of their small sizes and deep locations. In this study, we explore the capability of high-resolution functional magnetic resonance imaging at 4 Tesla for mapping the retinotopic organization in the lateral geniculate nucleus (LGN). Our results show that the hemifield visual stimulation only activates LGN in the contralateral hemisphere, and the lower-field and upper-field visual stimulations activate the superior and inferior portion of LGN, respectively. These results reveal a similar retinotopic organization between the human and nonhuman primate LGN and between LGN and the primary visual cortex. We conclude that high-resolution functional magnetic resonance imaging is capable of functional mapping of suborganizations in small nuclei together with cortical activation. This will have an impact for studying the thalamocortical networks in the human brain.
Center for Magnetic Resonance Research, Radiology Department, University of Minnesota School of Medicine, 2021 Sixth Street SE, Minneapolis, MN 55455, USA. wei@cmrr.umn.edu
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Chen
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Zhu
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Thulborn
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Ugurbil
D000328:Adult; D000818:Animals; D001931:Brain Mapping; D003118:Color Perception / Q000502:physiology*; D007839:Functional Laterality; D005829:Geniculate Bodies / Q000033:anatomy & histology / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D010775:Photic Stimulation; D011323:Primates; D012160:Retina / Q000502:physiology*; D014793:Visual Cortex / Q000502:physiology*; D014794:Visual Fields; D014795:Visual Pathways / Q000502:physiology*