Poor outcome of autologous stem cell transplantation for adult T cell leukemia/lymphoma: a case report and review of the literature.
A limited number of patients with adult T cell leukemia/lymphoma (ATL) who received autologous stem cell transplantation (ASCT) have been reported. We report here a case of fatal systemic Candida krusei infection in a female patient with ATL undergoing ASCT. All of the eight patients (including seven patients in the literature) with ATL who received ASCT developed relapse of ATL or death due to ASCT complication, irrespective of subtype or remission state of ATL, source or selection of SCT or conditioning regimen. At present, ASCT appears to provide little benefit for ATL in contrast to that for other types of aggressive non-Hodgkin's lymphoma.
Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine, Japan.
K
K
Tsukasaki
T
T
Maeda
K
K
Arimura
J
J
Taguchi
T
T
Fukushima
Y
Y
Miyazaki
Y
Y
Moriuchi
K
K
Kuriyama
Y
Y
Yamada
M
M
Tomonaga
D000328:Adult; D002177:Candidiasis / Q000209:etiology* / Q000503:physiopathology; D017809:Fatal Outcome; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D015458:Leukemia, T-Cell / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D016399:Lymphoma, T-Cell / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D012008:Recurrence; D014182:Transplantation, Autologous