Penetration of meropenem in lung, bronchial mucosa, and pleural tissues.
Lung, bronchial mucosa, and pleural tissue samples were obtained from 14 patients undergoing lung surgery 1 to 5 h after administration of 1 g of meropenem. The mean (range) peak concentrations of meropenem were 3.9 (0.2 to 8.2), 6.6 (3.0 to 13.3), and 2.8 (0.6 to 7.8) mg/kg of tissue, respectively, exceeding the MICs at which 90% of isolates are inhibited for most respiratory pathogens.
Infectious Diseases Clinic, Erasme Hospital, Université Libre de Bruxelles, Belgium. baudouin.byl@ulb.ac.be
B
B
Byl
F
F
Jacobs
I
I
Roucloux
P
P
de Franquen
M
M
Cappello
J P
JP
Thys
D000328:Adult; D000368:Aged; D001980:Bronchi / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D008168:Lung / Q000378:metabolism*; D000077731:Meropenem; D008875:Middle Aged; D009092:Mucous Membrane / Q000378:metabolism; D010994:Pleura / Q000378:metabolism*; D013845:Thienamycins / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D013845:Thienamycins; D000077731:Meropenem