[Nitric oxide in dengue pathology].
Nitric oxide (NO) is a multifunctional molecule that is involved in citotoxic as well as citoprotective processes, it's synthesis is highly regulated by the cell because an alteration in NO production is associated with a variety of pathologies, such as Septic, Anaphylactic and Hemorrhagic Shock. The clinical feature of dengue virus infection has a spectrum that goes from mild, dengue fever, to a severe disease, dengue hemorrhagic fever/dengue shock. Here, some evidences are discussed that links NO with the pathology of the severe disease cause by dengue virus.
Facultad de Medicina, Instituto de Biomedicina, U.C.V. Providencia a San Nicolás, San José, Caracas, Venezuela. mrodri@telcel.net.ve
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Rodriguez-Ortega
D003715:Dengue / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D009569:Nitric Oxide / Q000096:biosynthesis / Q000378:metabolism*; D019595:Severe Dengue / Q000378:metabolism / Q000503:physiopathology
D009569:Nitric Oxide