Mechanism of Shigella entry into epithelial cells.
Shigella, the causative agent of bacillary dysentery, invades epithelial cells by reorganizing the cell cytoskeleton during bacterial entry. This entry process requires the Shigella Ipa proteins that are secreted by a type III secretion apparatus and that act in concert to fine tune cell responses. Actin polymerization at the site of entry is dependent on the IpaB and IpaC proteins, whereas IpaA further modulates cytoskeletal rearrangements by binding to vinculin.
Unité de Pathogénie Microbienne Moléculaire INSERM U389 Institut Pasteur 28 rue du Dr. Roux 75724 Paris Cedex 15 France. gtranvan@pasteur.fr
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D000818:Animals; D000942:Antigens, Bacterial / Q000378:metabolism*; D017209:Apoptosis; D001426:Bacterial Proteins / Q000378:metabolism*; D016466:CHO Cells; D006224:Cricetinae; D003599:Cytoskeleton / Q000502:physiology; D004847:Epithelial Cells / Q000166:cytology / Q000382:microbiology*; D020558:GTP Phosphohydrolases / Q000378:metabolism; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism; D016023:Integrins / Q000378:metabolism; D012760:Shigella / Q000472:pathogenicity / Q000502:physiology*; D016596:Vinculin / Q000378:metabolism; D014774:Virulence
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D018960:Hyaluronan Receptors; D016023:Integrins; C063664:IpaA protein, Shigella flexneri; D016596:Vinculin; C087447:ipaB protein, Shigella; C092342:IpaC protein, Shigella; D020558:GTP Phosphohydrolases