[Influence of prostatilen on smooth muscle organs functional activity in surgical patients (clinical and experimental study)].
The action of prostatilen on contractile activity of smooth muscles of isolated line slices of urine bladder of Wistar rats (myography) and arterial vessels of cat kidneys (resistography) was studied. On the basis of clinical cases effectiveness of prostatilen was analysed as a treatment restorting urine bladder function in acute reflex urinary retention after operations in the area of rectal sphincter, as well as in treatment of patients with chronic prostatitis. It is shown, that prostatilen produces contractile action on smooth muscles of renal blood vessels in cats and urine bladder walls in rats and it raises contractile activity of smooth muscles of human urine bladder. The results of experimental and clinical investigations make it possible to recommend the application of this bioregulating preparation for treatment and prophylaxis of disturbances in urination.
Al'-Shukri
S Kh
SKh
Aĭvazian
A I
AI
Barabanov
S V
SV
Barabanova
V V
VV
Bobkov
Iu A
IuA
Gorbachev
A G
AG
Parastaeva
M M
MM
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000818:Animals; D002415:Cats; D002908:Chronic Disease; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000503:physiopathology*; D010455:Peptides / Q000627:therapeutic use*; D011469:Prostatic Diseases / Q000150:complications / Q000188:drug therapy / Q000601:surgery; D051381:Rats; D017208:Rats, Wistar; D001743:Urinary Bladder / Q000187:drug effects / Q000503:physiopathology*; D016055:Urinary Retention / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*
D000276:Adjuvants, Immunologic; D010455:Peptides; C069549:prostatilen