Protective role of DL-alpha-lipoic acid against mercury-induced neural lipid peroxidation.
Experimental neurotoxicity in rat models was induced by an intramuscular injection of mercuric chloride. dl-alpha-lipoic acid was administered as an antidote in three protocols of experimental design. Two protocols of short-term exposure of mercury was designed, one with prophylactic therapy and the other with curative therapy of lipoic acid. The third protocol was with prophylactic therapy of lipoic acid on long-term exposure of mercury. Enhanced lipid peroxidation, depleted non-enzymic and perturbed enzymic antioxidant status were observed in cerebral cortex, cerebellum and sciatic nerves of the toxic groups. The ameliorating effect of lipoic acid and its therapeutic efficacy during various modes of therapy, on the antioxidant status was established in the nervous tissues.
Department of Medical Biochemistry, Dr AL Mudaliar Post Graduate Institute of Basic Medical Sciences, Madras University, Taramani, Madras, 600 113, India.
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B
Anuradha
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Varalakshmi
D000818:Animals; D002531:Cerebellum / Q000737:chemistry / Q000187:drug effects; D002540:Cerebral Cortex / Q000737:chemistry / Q000187:drug effects; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects*; D008628:Mercury / Q000633:toxicity*; D009422:Nervous System Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control*; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000737:chemistry / Q000187:drug effects; D008063:Thioctic Acid / Q000494:pharmacology* / Q000627:therapeutic use; D013997:Time Factors
D008063:Thioctic Acid; D008628:Mercury