[Use of xenogenic lyophilized hepatocytes in the treatment of acute and chronic liver diseases].
Therapeutic effect of lyophilized xenogenic hepatocytes was demonstrated on 30 dogs with acute hepatic failure and on white mice. The major biochemical values were corrected and the yeast fermentation test showed biological activity of isolated hepatocytes. Clinically, lyophilized hepatocytes were used in the treatment of patients with acute hepatic failure: orally in 47 and for extracorporeal dialysis in 8. The therapeutic effect of lyophilized hepatocytes is based on active detoxication and hemostasis correction. Clinical, laboratory, and instrumental studies showed improvement of the clinical status, decreased encephalopathy, and accelerated repair processes in the liver. Addition of lyophilized hepatocytes to combined therapy decreased the mortality by 2.5 times.
S G
SG
Musselius
N V
NV
Vasina
L V
LV
Gladskikh
D000284:Administration, Oral; D000818:Animals; D017690:Cell Transplantation; D004285:Dogs; D005612:Freeze Drying; D006801:Humans; D008099:Liver / Q000166:cytology* / Q000378:metabolism; D017093:Liver Failure / Q000628:therapy*; D008115:Liver Regeneration; D051379:Mice; D006435:Renal Dialysis; D013552:Swine; D013997:Time Factors; D014183:Transplantation, Heterologous