Evaluation of possible mechanism of anti-ulcerogenic activity of UL-409, a herbal preparation.
UL-409, a herbal preparation was investigated for its anti-ulcerogenic activity and possible mechanism of action in different experimental models. Oral administration of UL-409 at a dose of 600 mg/kg significantly reduced the volume of gastric secretion, total acidity and free acidity in aspirin + pylorus-ligated rats. The drug appeared to strengthen the gastric mucosal defense mechanism by significantly increasing the total carbohydrate:protein ratio in aspirin + pylorus-ligated rats. The major mechanism involved appears to be due to promotion of mucosal protection by augmenting gastric mucin activity. Pre-treatment with UL-409 showed inhibition of alcohol-induced contraction of isolated rat fundus preparation which was reversed by indomethacin suggesting a possible involvement of the cyclo-oxygenase system.
Venkataranganna
M V
MV
R&D Centre, The Himalaya Drug Company Bangalore, India.
Gopumadhavan
S
S
Sundaram
R
R
Mitra
S K
SK
D000284:Administration, Oral; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001241:Aspirin; D002241:Carbohydrates / Q000032:analysis; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D005744:Gastric Acid / Q000737:chemistry / Q000378:metabolism; D005752:Gastric Mucins / Q000032:analysis; D005753:Gastric Mucosa / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008026:Ligation; D008297:Male; D008515:Medicine, Ayurvedic; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D011506:Proteins / Q000032:analysis; D011708:Pylorus; D051381:Rats; D017208:Rats, Wistar
D000897:Anti-Ulcer Agents; D002241:Carbohydrates; D016861:Cyclooxygenase Inhibitors; D005752:Gastric Mucins; D010936:Plant Extracts; D011506:Proteins; C104084:UL 409; D000431:Ethanol; D001241:Aspirin; D007213:Indomethacin