Influence of baseline values. I: Effects on plasma total cholesterol and triglyceride levels during doxazosin treatment for hypertension.
Forty-six African patients with essential hypertension aged 40 to 65 years had plasma total cholesterol and triglyceride levels determined at four different periods during a 12-month treatment with doxazosin. The patients were classified according to their pretreatment (baseline) values into 'low', 'medium' and 'high' baseline value groups. The mean total cholesterol levels significantly decreased in the three baseline groups while mean triglyceride levels reduced only in the patients that belonged to the medium and high baseline value groups. The baseline values of total cholesterol did not influence the beneficial cholesterol changes in all the patients, while the lack of significant favorable triglyceride changes was influenced by the low baseline values of triglyceride of the patients during doxazosin treatment. A similar study involving lipoprotein fractions and sub-fractions is also in progress.
Ahaneku
J E
JE
Department of Chemical Pathology, College of Health Sciences, Nnamdi Azikiwe University, Nigeria. ahanekuj@hama-med.ac.jp
Taylor
G O
GO
Agbedana
E O
EO
Walker
O
O
Salako
L A
LA
D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood*; D017292:Doxazosin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood*
D000959:Antihypertensive Agents; D014280:Triglycerides; D002784:Cholesterol; D017292:Doxazosin