Extranodal follicular dendritic cell sarcoma of the palate.
Follicular dendritic cell tumors are uncommon and usually occur in lymph nodes. We report the case of a follicular dendritic cell tumor that occurred in the palate of a 14-year-old boy and manifested itself as a nodular mass. Histologically, the neoplasm consisted of spindle-shaped or oval-shaped cells with eosinophilic cytoplasms and nuclei with delicate, dispersed chromatin. The lesional cells were principally arranged in diffuse, fascicular patterns with vaguely whorled or storiform areas. Focal multinucleate tumor giant cells and lymphocytes were observed throughout the neoplasm. Immunohistochemically, tumor cells were positive for the follicular dendritic cell markers CD21, CD35, and CD23 and for S-100 protein, CD68, and muscle-specific actin. Tumor cells were negative for LCA, CD20, EMA, CK (AE1/AE3), HMB45, and CD34. Lymphocytes were positive for LCA and CD45RO. Although follicular dendritic cell sarcoma is a very uncommon tumor, it should be included in the differential diagnosis of tumors in this location.
Department of Oral Pathology, School of Dentistry, University of São Paulo, SP, Brazil.
V C
VC
Araújo
M T
MT
Martins
F S
FS
Salmen
N S
NS
Araújo
D000293:Adolescent; D000951:Antigens, Neoplasm / Q000032:analysis; D014408:Biomarkers, Tumor; D003713:Dendritic Cells / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D010157:Palatal Neoplasms / Q000737:chemistry / Q000473:pathology*; D012509:Sarcoma / Q000737:chemistry / Q000473:pathology*
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor