[Method of medicamentous saturation of lymphatic system].
Data of experimental study in 18 mongrel dogs followed by clinical trial in 96 patients are represented, which concerns a method of indirect medicamentous saturation of lymphatic system, consisted in creation of medicamentous subcutaneous infiltration in the thighs followed by pneumocompression. Gentamycin contents in blood lymphatics and organs of experimental animals was studied in various periods of time. The obtained data have determined identity of the effect with the method of introduction of the antibiotics together with the media, which possess hyaluronidaze-like action, and followed by 2 hours duration phlebohypertension (by V.M.Buyanov, 1991). It promotes reduction of time for the procedure more than 3 times and gives possibility to avoid introduction of additional preparations, which are unnecessary load to the procedure. Gentamycin contents in blood serum of patients in various time intervals are demonstrated.
Iarema
I V
IV
Merzhvinskiĭ
I A
IA
Shishlo
V I
VI
Vazilo
V E
VE
Pavlov
V V
VV
D000328:Adult; D000368:Aged; D000818:Animals; D004285:Dogs; D016503:Drug Delivery Systems; D005500:Follow-Up Studies; D005839:Gentamicins / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D007279:Injections, Subcutaneous; D008196:Lymph / Q000378:metabolism; D008208:Lymphatic System / Q000187:drug effects* / Q000378:metabolism; D008214:Lymphocytes / Q000378:metabolism; D008875:Middle Aged; D009779:Occlusive Dressings; D013848:Thigh
D005839:Gentamicins