Anesthesia, consciousness and hydrophobic pockets--a unitary quantum hypothesis of anesthetic action.
1. A consensus view holds that anesthetics act by van der Waals forces in hydrophobic pockets of select brain proteins to ablate consciousness. 2. What is consciousness? Enigmatic features of consciousness (e.g. 'qualia', binding, non-computability, pre-conscious-->conscious transition, nondeterministic free will) may be explained by the occurrence of quantum coherent states in the brain. 3. Van der Waals electron pair couplings (London forces) in hydrophobic pockets in non-anesthetic (conscious) conditions are a particular type of quantum capable of supporting macroscopic quantum coherence. 4. The mechanism of anesthetics may be to inhibit electron mobility and London forces necessary for quantum states and consciousness in hydrophobic pockets of select brain proteins.
Department of Anesthesiology, The University of Arizona, Tucson, USA. hameroff@u.arizona.edu
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D000758:Anesthesia; D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects / Q000502:physiology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003243:Consciousness / Q000187:drug effects*; D006801:Humans; D011789:Quantum Theory
D000777:Anesthetics