Increased tumor growth in mice exposed to inhaled isobutyl nitrite.
Epidemiological studies have correlated the incidence of Kaposi's sarcoma (KS) in AIDS with a history of abuse of nitrite inhalants. To determine if exposure to nitrite inhalants could alter tumor growth, syngeneic PYB6 tumor cells were injected into groups of mice. Exposure of these mice to inhaled isobutyl nitrite increased both the tumor incidence and the tumor growth rate by almost 4-fold. Following only five daily exposures to the inhalant, the induction of specific T cell mediated cytotoxicity was inhibited by 36%. Similar inhalation exposures inhibited the tumoricidal activity of activated macrophages by 86%. The data suggest that exposure to abuser levels of a nitrite inhalant compromised tumor surveillance mechanisms.
Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock 72205, USA. Soderberglees@exchange.uams.edu
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D000280:Administration, Inhalation; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D013287:Illicit Drugs / Q000009:adverse effects*; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D009573:Nitrites / Q000008:administration & dosage / Q000633:toxicity*; D012513:Sarcoma, Experimental / Q000473:pathology*; D013268:Stimulation, Chemical; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects; D014407:Tumor Cells, Cultured
D013287:Illicit Drugs; D009573:Nitrites; C018086:isobutyl nitrite