Workshop on irradiated larval vaccines.
The development of anthelmintic resistance in gastrointestinal parasites of sheep and goats has meant that there is an urgent need for non-chemical control of these parasites. In order to investigate a potential alternative method of control, a workshop on irradiated larval vaccines (ILV) was held in conjunction with the Second International Conference on Novel Approaches to the Control of Helminth Parasites of Livestock. The objectives of the workshop were to: (1) Review knowledge of irradiated helminth vaccines through the presentation of invited and contributed papers. (2) Identify opportunities for an ILV and in which host/parasite/production systems. (3) Determine what are the gaps in knowledge required to produce and apply an ILV. The workshop concluded that ILVs could be useful as research tools in the further definition of immune responses to parasites and in stimulating the immune response in young sheep and goats to facilitate the estimating of heritability of faecal egg counts. Although the workshop identified some problems associated with a live attenuated vaccine, an ILV could be a useful control measure in the production systems identified by the workshop. Before an ILV could be used on farms, additional research is required into the period of protection afforded by an ILV especially under field conditions. The efficacy of an ILV could be improved by interaction between host genotype and nutritional status and is deserving of further investigation.
CSIRO Division of Animal Production, Pastoral Research Laboratory, Armidale, NSW, Australia. llejambr@ram.chiswick.anprod.csiro.au
L F
LF
Le Jambre
G D
GD
Gray
T R
TR
Klei
D000818:Animals; D015511:Goat Diseases / Q000517:prevention & control*; D006041:Goats; D007814:Larva / Q000276:immunology / Q000528:radiation effects; D012756:Sheep; D012757:Sheep Diseases / Q000517:prevention & control*; D014251:Trichostrongyloidea / Q000254:growth & development / Q000276:immunology*; D014252:Trichostrongyloidiasis / Q000517:prevention & control / Q000662:veterinary*; D014613:Vaccines, Attenuated
D014613:Vaccines, Attenuated