NMR tools for biotechnology.
Recent developments in NMR spectroscopy verify that NMR continues to be an exciting area of research. These advances can be placed into three general categories: new hardware; new techniques; and novel applications. The hardware developments include many advances in the area of flow NMR and some new probe designs. The new techniques include several ways to edit the NMR spectra of mixtures without using chromatographic separation. These new NMR tools are now allowing us to analyze complex mixtures, combinatorial-chemistry libraries, bound drugs, unstable compounds, very small samples, and heterogeneous samples.
Keifer
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Varian NMR Instruments 3120 Hansen Way D-298 Palo Alto CA 94304-1030 USA. paul.keifer@nmr.varian.com
D001709:Biotechnology / Q000379:methods / Q000639:trends*; D002851:Chromatography, High Pressure Liquid; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods*; D012116:Resins, Plant / Q000138:chemical synthesis / Q000737:chemistry; D013329:Structure-Activity Relationship
D008024:Ligands; D012116:Resins, Plant