Formulation of triamcinolone acetonide pellets suitable for coating and colon targeting.
Spherical pellets containing 5% of triamcinolone acetonide (TA) were formed by extrusion/spheronization following formulation with microcrystalline cellulose (MCC) and/or a hydrophilic excipient (lactose, sodium carboxymethylcellulose or beta-cyclodextrin, beta-CD). Their suitability for coating, with a view to colonic drug delivery, was assessed in terms of their size, sphericity and dissolution test response. Best results were afforded by 5:90:5 MCC-beta-CD-TA pellets obtained by complexation of TA with beta-CD prior to addition of MCC, extrusion and spheronization.
Villar-López
M E
ME
Departamento Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela, Spain.
Nieto-Reyes
L
L
Anguiano-Igea
S
S
Otero-Espinar
F J
FJ
Blanco-Méndez
J
J
D002626:Chemistry, Pharmaceutical; D003106:Colon / Q000378:metabolism*; D003505:Cyclodextrins / Q000008:administration & dosage; D005938:Glucocorticoids / Q000008:administration & dosage*; D012995:Solubility; D014222:Triamcinolone Acetonide / Q000008:administration & dosage* / Q000378:metabolism; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D005938:Glucocorticoids; D047392:beta-Cyclodextrins; D014222:Triamcinolone Acetonide; C031215:betadex