An epidemic of occupational contact dermatitis from an immersion oil for microscopy in laboratory personnel.
Since November 1997, 14 successive cases of occupational contact dermatitis were observed in 13 laboratory technicians and 1 physician, working in a genetics laboratory in Leuven (Belgium) in 3 laboratories of bacteriology in Strasbourg, Montbeliard and Angers, and in the laboratory of hematology in Bordeaux (France). The dermatitis, located on the hands, forearms and face, relapsed after each exposure to an immersion oil for microscopy. Patch tests performed in 10 patients were positive to epoxy resin (ER) in the European standard series (10/10 patients) and to newly formulated Leica immersion oil (7/7), 1 patient testing negatively with the former oil. A breakdown performed in 2 patients with the oil's ingredients confirmed sensitization to liquid modified ER components, contained at >80% concentration in the oil. The presence of DGEBA was demonstrated by HPLC analysis at a +/-30% rate. Although the safety data sheet indicated a revision of the formula, nobody was alerted to the risk of sensitization and the need for skin protection. ERs, as a source of occupational allergy, can provoke epidemics of contact dermatitis in industry. This report of epidemic contact dermatitis from ERs, used for their optical properties in an immersion oil for microscopy, emphasizes the need for perpetual vigilance in occupational medicine and the usefulness of multicentre contacts in dermato-allergology.
Le Coz
C J
CJ
Consultation de Dermato-Allergie, Clinique Dermatologique des Hôpitaux Universitaires de Strasbourg, France.
Coninx
D
D
Van Rengen
A
A
El Aboubi
S
S
Ducombs
G
G
Benz
M H
MH
Boursier
S
S
Avenel-Audran
M
M
Verret
J L
JL
Erikstam
U
U
Bruze
M
M
Goossens
A
A
D000328:Adult; D001530:Belgium / Q000453:epidemiology; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D017449:Dermatitis, Allergic Contact / Q000453:epidemiology / Q000209:etiology*; D009783:Dermatitis, Occupational / Q000453:epidemiology / Q000209:etiology*; D004853:Epoxy Resins / Q000009:adverse effects*; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D017056:Medical Laboratory Personnel; D008853:Microscopy; D008875:Middle Aged; D009821:Oils / Q000737:chemistry; D010328:Patch Tests
D004853:Epoxy Resins; D009821:Oils