The mathematical modelling of cell kinetics in corneal epithelial wound healing.
This paper considers the comparison of experimental spatial and temporal data of mitotic rates measured during corneal epithelial wound healing (CEWH) of a rat model with the predictions of a computer modelling framework. We begin by briefly showing that previous models, used in the study of corneal epithelial wound healing speeds, are inadequate for the study of cell kinetics. We proceed to formulate a new modelling framework more suited to such a study. This framework is simulated in its simplest form, and the results from this motivate a new realisation of the modelling framework, including a caricature of age structuring. Finally, a model with a simple representation of juxtacrine signalling is considered. The final model captures many, though not all, of the trends of the experimental data. This paper thus lays a foundation for the modelling of the cell kinetics of corneal epithelial wound healing, and yields valuable insight regarding the important mechanisms a model should consider in order to reproduce the observed experimental trends.
Gaffney
E A
EA
Centre for Mathematical Biology, Mathematical Institute, 24-29 St. Giles, Oxford OX1 3LB, UK. gaffney@maths.ox.ac.uk
Maini
P K
PK
Sherratt
J A
JA
Tuft
S
S
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D003198:Computer Simulation; D019573:Epithelium, Corneal / Q000293:injuries* / Q000473:pathology; D008938:Mitosis / Q000502:physiology; D008954:Models, Biological; D051381:Rats; D014945:Wound Healing / Q000502:physiology*