Functional design in the actin cytoskeleton.
Changes in cell shape, anchorage and motility are all associated with the dynamic reorganisation of the architectural arrays of actin filaments that make up the actin cytoskeleton. The relative expression of these functionally different actin filament arrays is intimately linked to the pattern of contacts that a cell develops with its extracellular substrate. Cell polarity is acquired by the development of an asymmetric pattern of substrate contacts, effected in a specific, site-directed manner by the delivery of adhesion-site modulators along microtubules.
Small
J V
JV
Institute of Molecular Biology Austrian Academy of Sciences Billrothstrasse 11 A-5020 Salzburg Austria. jvsmall@imb.oeaw.ac.at
Rottner
K
K
Kaverina
I
I
D000199:Actins / Q000737:chemistry*; D000818:Animals; D001692:Biological Transport; D002448:Cell Adhesion; D002460:Cell Line; D002465:Cell Movement; D016764:Cell Polarity; D048429:Cell Size; D003599:Cytoskeleton / Q000737:chemistry*; D004398:Dyneins / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000378:metabolism; D016547:Kinesins / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism; D008954:Models, Biological; D009218:Myosins / Q000378:metabolism; D020744:rac GTP-Binding Proteins; D020743:rhoB GTP-Binding Protein
D000199:Actins; D008565:Membrane Proteins; D019204:GTP-Binding Proteins; D009218:Myosins; D004398:Dyneins; D016547:Kinesins; D020744:rac GTP-Binding Proteins; D020743:rhoB GTP-Binding Protein