Mast cells as sentinels of innate immunity.
Mast cells are widely regarded as important effector cells in immune responses associated with Th2 cells and IgE. Recent work shows that they can also contribute significantly to the expression of innate immunity; furthermore, survival in a model of acute bacterial infection that is dependent on complement and mast cells can be greatly enhanced by long-term treatment of mice with the kit ligand (stem cell factor) at least in part because of the effects of such treatment on mast cell numbers and/or function. These findings not only indicate that mast cells can represent a critical component of host defense in natural immunity but also suggest that mast cell function in this setting can be manipulated for therapeutic ends.
Department of Pathology/Division of Experimental Pathology, Research North Building, Beth Israel Deaconess Medical Center-East, Boston, MA 02215, USA. sgalli@bidmc.harvard.edu.
S J
SJ
Galli
M
M
Maurer
C S
CS
Lantz
D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D008407:Mast Cells / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D014409:Tumor Necrosis Factor-alpha