Developmental regulation of immune system gene rearrangement.
Rearrangement of antigen receptors in the immune system is mediated through the action of complex enhancers which function in both a developmentally stage-specific and a cell-type-specific manner to demethylate DNA, open chromatin structure and tether the recombination machinery to one preferred allele at each locus.
Cedar
H
H
Department of Cellular Biochemistry, The Hebrew University Hadassah Medical School, Jerusalem, Israel. cedar@md2.huji.ac.il.
Bergman
Y
Y
D000818:Animals; D018507:Gene Expression Regulation, Developmental; D015321:Gene Rearrangement / Q000235:genetics*; D005803:Genes, Immunoglobulin / Q000235:genetics*; D006801:Humans; D007107:Immune System / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*