Functions of gelsolin: motility, signaling, apoptosis, cancer.
Several new members of the gelsolin family have been discovered in the past year. Determination of the structure of gelsolin and identification of lysophosphatidic acid as a negative regulator provide novel functional insights. Gelsolin is an obligate downstream effector of Rac for motility in dermal fibroblasts, regulates phosphoinositide signaling pathways and ion channel function in vivo, and acts as both a regulator and effector of apoptosis.
Genetics Laboratory Hematology Division Brigham and Women's Hospital 221 Longwood Avenue Boston MA 02115 USA. kwiatkowski@calvin.bwh.harvard.edu
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D000686:Amyloidosis / Q000378:metabolism; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D018260:Gelsolin / Q000737:chemistry* / Q000502:physiology*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D050356:Lipid Metabolism; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D008840:Microfilament Proteins / Q000378:metabolism
C114228:AVIL protein, human; D018260:Gelsolin; D007473:Ion Channels; D008565:Membrane Proteins; D008840:Microfilament Proteins; C109413:SVIL protein, human; C491615:Svil protein, mouse; C065395:scinderin