The role of neisserial Opa proteins in interactions with host cells.
Pathogenic Neisseria spp. possess a repertoire of phase-variable Opa proteins that mediate various pathogen--host cell interactions, including bacterial engulfment by epithelial cells and opsonin-independent phagocytosis by professional phagocytes. Recent studies have identified cellular targets recognized by defined Opa proteins and have begun to reveal host signalling events involved in mediating these Opa-dependent cellular processes.
Dept Infektionsbiologie, Max-Planck-Institut für Biologie, Tübingen, Germany.
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D000818:Animals; D000942:Antigens, Bacterial / Q000502:physiology*; D015703:Antigens, CD / Q000378:metabolism; D000943:Antigens, Differentiation / Q000378:metabolism; D015815:Cell Adhesion Molecules; D004847:Epithelial Cells / Q000382:microbiology; D019812:Heparan Sulfate Proteoglycans / Q000378:metabolism; D006801:Humans; D009344:Neisseria gonorrhoeae / Q000502:physiology*; D009345:Neisseria meningitidis / Q000502:physiology*
D000942:Antigens, Bacterial; D015703:Antigens, CD; D000943:Antigens, Differentiation; C069847:CD66 antigens; D015815:Cell Adhesion Molecules; D019812:Heparan Sulfate Proteoglycans; C050308:opacity proteins