High dose chemotherapeutic strategies in the treatment of epithelial ovarian carcinoma.
High dose chemotherapy with stem cell rescue has been used in an attempt to overcome chemotherapy resistance and increase survival in patients with poor prognosis epithelial ovarian cancer. Untreated patients with advanced stage disease and those with chemosensitive recurrent disease do better in terms of response rates as well as duration of response and overall survival. Newer strategies using multiple cycles of dose intense therapy may improve results although it will be difficult to document changes in the natural history of advanced ovarian cancer without the completion of randomized phase III trials.
Division of Hematology-Oncology, Massachusetts General Hospital, Boston, USA.
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McAfee
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Seiden
D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002277:Carcinoma / Q000628:therapy*; D017326:Clinical Trials, Phase III as Topic; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D010051:Ovarian Neoplasms / Q000628:therapy*; D016032:Randomized Controlled Trials as Topic
D000970:Antineoplastic Agents