Low-dose cyclosporin A therapy in children with refractory immune thrombocytopenic purpura.
Although splenectomy is the most effective treatment for chronic idiopathic thrombocytopenic purpura (ITP), many post-splenectomy patients have recurrent thrombocytopenia refractory to multiple medical therapies. Three consecutive patients with relapsed ITP after splenectomy and who were refractory to multiple medical therapies were treated with low dose cyclosporin A (CsA). In all 3 patients, the platelet count increased dramatically within 1 month from the onset of CsA therapy. The only detectable toxicity was hypomagnesemia and mild hypertension in 1 patient. CsA may be efficacious in treating patients with chronic ITP, which is refractory to all medical and surgical therapies currently being used.
Moskowitz
I P
IP
Department of Pediatrics, University of Wisconsin Children's Hospital, Madison, USA.
Gaynon
P S
PS
Shahidi
N T
NT
Cripe
T P
TP
D000293:Adolescent; D016572:Cyclosporine / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D010976:Platelet Count; D011696:Purpura, Thrombocytopenic / Q000188:drug therapy* / Q000276:immunology*
D007166:Immunosuppressive Agents; D016572:Cyclosporine