[A case of hyalinizing spindle cell tumor with giant rosettes in the presacral region. Immunohistochemical and ultrastructural study].
Hyalinizing spindle cell tumor with giant rosettes is a slowly growing tumor with a risk of local recurrence in case of incomplete surgical excision that could be regarded as a distinctive type of low-grade fibroblastic tumor. We report a case involving the presacral area. This tumor was composed of areas of bland spindle cell proliferation with a fascicular pattern in a fibrous or myxoid stroma, intermixed with giant rosettes consisting of rounded cells surrounding a central collagen core. The tumor expressed vimentin, and, for cells comprising the rosettes, S-100 protein, NSE and CD-57. These latter cells exhibited ultrastructural features of Schwann cells, the tumoral cells of fascicular area exhibiting features of fibroblastic cells. Flow cytometry showed DNA-aneuploidy and a very low S-phase fraction. This tumor appeared to be composed of two cellular components, fibroblastic and Schwann cells, located, at the opposite of neurofibroma, in two distinct areas.
Service d'Anatomie Pathologique, Groupe Hospitalier Cochin, Port-Royal, France.
G
G
de Pinieux
P
P
Anract
M
M
le Charpentier
A
A
Carlioz
J M
JM
Coindre
P
P
Vielh
B
B
Tomeno
M
M
Forest
D000782:Aneuploidy; D018959:CD57 Antigens / Q000032:analysis; D004273:DNA, Neoplasm / Q000032:analysis; D005347:Fibroblasts / Q000473:pathology; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D012447:Sacrum; D012583:Schwann Cells / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000737:chemistry / Q000473:pathology*; D014746:Vimentin / Q000032:analysis
D018959:CD57 Antigens; D004273:DNA, Neoplasm; D009418:S100 Proteins; D014746:Vimentin; D010751:Phosphopyruvate Hydratase