Fosfomycin alters lipopolysaccharide-induced inflammatory cytokine production in mice.
To determine the mechanisms of immunomodulating action of fosfomycin (FOF), we examined its effect on the production of inflammatory cytokines in mice injected with lipopolysaccharide (LPS). Treatment with FOF significantly lowered the peak serum levels of tumor necrosis factor alpha and interleukin-1 beta, indicating that FOF alters inflammatory cytokine production after LPS stimulation.
Matsumoto
T
T
Department of Microbiology, Toho University School of Medicine, Tokyo, Japan. tetsu@med.toho-u.ac.jp
Tateda
K
K
Miyazaki
S
S
Furuya
N
N
Ohno
A
A
Ishii
Y
Y
Hirakata
Y
Y
Yamaguchi
K
K
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016207:Cytokines / Q000096:biosynthesis* / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004731:Endotoxins / Q000633:toxicity*; D004926:Escherichia coli; D005578:Fosfomycin / Q000494:pharmacology*; D007249:Inflammation / Q000139:chemically induced / Q000378:metabolism*; D007375:Interleukin-1 / Q000096:biosynthesis / Q000097:blood; D008070:Lipopolysaccharides / Q000633:toxicity*; D008297:Male; D051379:Mice; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D000900:Anti-Bacterial Agents; D016207:Cytokines; D004731:Endotoxins; D007375:Interleukin-1; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; D005578:Fosfomycin; C044101:endotoxin, Escherichia coli