Oxygen enhanced MR ventilation imaging of the lung.
The current work is a continuation of a new MRI technique that was proposed for the non-invasive assessment of regional lung ventilation using inhaled molecular oxygen as a T1 contrast agent. Several improvements of this technique are described in this work. The signal-to-noise ratio in the ventilation-scan images was optimized using a centrically reordered single-shot RARE sequence with a short effective echo time and short inter-echo spacing. The contrast-to-noise ratio was improved using an optimized inversion delay time. The optimized MR-ventilation-scan was successfully performed in healthy volunteers and in an animal model with airway obstruction. The experimental results demonstrate the feasibility and clinical potential of the MR ventilation imaging technique for assessment of regional pulmonary function.
Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. qchen@bidmc.harvard.edu
Q
Q
Chen
P M
PM
Jakob
M A
MA
Griswold
D L
DL
Levin
H
H
Hatabu
R R
RR
Edelman
D000402:Airway Obstruction / Q000175:diagnosis; D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage*; D004195:Disease Models, Animal; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008168:Lung / Q000033:anatomy & histology* / Q000502:physiology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010100:Oxygen; D012123:Pulmonary Ventilation / Q000502:physiology*; D012680:Sensitivity and Specificity; D013552:Swine
D003287:Contrast Media; D010100:Oxygen