[Experimentally inoculated human echinococcosis in piglets and a trial of the therapeutic preparation SK-1].
Experiments were made on 26-month-old piglets divided into 4 groups: Groups 1 and 4 included 5 piglets and Groups 2 and 3 comprised 8 animals. The piglets from Groups 1, 2, and 3 were peritoneally inoculated with 5000 protoscolices and acephalocysts of Echinococcus from patients with echinococcosis who had been operated on. On postinoculation day 60, Group 1 piglets were killed to measure the baseline weight of parasitic larvocysts (PL) developed by that time. On postinoculation day 61, Group 3 piglets continuously received feed in combination with CK-1 within 3 weeks. The mean daily doses of the agent were 0.05, 0.10, 0.25 g/kg, respectively. On day 91 following inoculation, all the animals were killed and dissected. The studies were made by using the procedures and formulas [9]. The growth suppression index for PL was 94.50, 92.39, and 96 for Groups 1, 2, and 3, respectively. Significant destruction of embryonic elements was revealed in 75-85% of PL in each treated animals. There was a tendency for blood indices to become normal in the treated animals. The acute toxicity of CK-1 was examined in outbred white mice, albino rats, chickens, piglets. The maximum non-lethal dose of CK-1 was 19 g/kg for white mice. The agent showed a low toxicity.
Streliaeva
A V
AV
Chebyshev
N V
NV
Sadykov
V M
VM
Pogosov
A G
AG
D000818:Animals; D000923:Anticestodal Agents / Q000627:therapeutic use* / Q000633:toxicity; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004443:Echinococcosis / Q000188:drug therapy* / Q000635:transmission; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000627:therapeutic use / Q000633:toxicity; D051381:Rats; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy* / Q000635:transmission; D013997:Time Factors
D000923:Anticestodal Agents; D010936:Plant Extracts