Structure-based and combinatorial search for new RNA-binding drugs.
The discovery by structure-based and combinatorial methods of new RNA-binding drugs presents great opportunities for pharmacological development against drug-resistant bacterial and viral pathogens. A handful of recent RNA structures and more numerous studies of the interaction of combinatorial libraries and oligomeric RNA-binding compounds are providing the foundation for effective RNA-targeted drug discovery programs.
Ribotargets Ltd Kett House Station Road Cambridge CB2 2JX UK.
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Afshar
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Prescott
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Varani
D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D008958:Models, Molecular; D016376:Oligonucleotides, Antisense / Q000737:chemistry / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000378:metabolism*; D012313:RNA / Q000737:chemistry* / Q000378:metabolism*; D013329:Structure-Activity Relationship
D016376:Oligonucleotides, Antisense; D004364:Pharmaceutical Preparations; D012313:RNA