Flurbiprofen-loaded nanospheres: analysis of the matrix structure by thermal methods.
We report the preparation and evaluation of flurbiprofen loaded-poly-epsilon-caprolactone nanospheres obtained by solvent displacement method. Characterization by thermal methods, infrared spectroscopy and X-ray diffraction analysis can reveal the dispersion state of the drug inside the nanospheres. Such information predicts the stability of the particles and the drug release behaviour. The study has indicated the presence of a molecular dispersed system. In addition, construction of a phase diagram has allowed us to determine the drug/polymer ratios at which flurbiprofen has the highest entrapment efficiency.
Physicochemical Unit, Department of Pharmacy, Faculty of Pharmacy, Avda Juan XXIII s/n, 08028, Barcelona, Spain.
F
F
Gamisans
F
F
Lacoulonche
A
A
Chauvet
M
M
Espina
M L
ML
García
M A
MA
Egea
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000032:analysis; D003692:Delayed-Action Preparations; D004055:Differential Thermal Analysis; D005480:Flurbiprofen / Q000008:administration & dosage* / Q000032:analysis; D008863:Microspheres; D020442:Poloxamer; D011091:Polyesters; D012997:Solvents; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry; D014961:X-Ray Diffraction
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D011091:Polyesters; D012997:Solvents; D020442:Poloxamer; C016240:polycaprolactone; D005480:Flurbiprofen