NMR and molecular dynamics studies of tachykinins: conformation of substance P fragment 4-11.
The conformation of the C-terminal octapeptide fragment of Substance P (SP4-11, Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2) has been investigated by 2D-NMR and MD methods. The octapeptide exists in a blend of conformations. The molecule seems to shuttle between conformations with gamma-bends either at Phe5 or Gly6 or Gln3 or Leu7 and between a nearly extended structure.
Bombay College of Pharmacy, Kalina, Mumbai, India.
E
E
Coutinho
S
S
Kamath
A
A
Saran
S
S
Srivastava
D000818:Animals; D003198:Computer Simulation; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D013373:Substance P / Q000737:chemistry*; D015320:Tachykinins / Q000737:chemistry*; D013696:Temperature
D015320:Tachykinins; D013373:Substance P