Molecular correlates of the murine Xce locus.
The murine Xce locus, first identified by Bruce Cattanach, influences the primary choice of the X chromosome to be inactivated. Methylation of a GC-rich region (DXPas34) that includes multiple 34 bp repeats and lies some 15 kb 3' to Xist has been shown to vary with Xce haplotype. The degree of methylation on the active X chromosome at this locus represents one of the few molecular correlates of Xce action currently available. Data relating to the specificity and other characteristics of this association are presented.
Unité de Génétique Moléculaire Murine, Institut Pasteur, Paris, France. pavner@pasteur.fr
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Avner
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Prissette
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Arnaud
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Courtier
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Cecchi
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Heard
D000818:Animals; D002460:Cell Line; D003001:Cloning, Molecular; D019175:DNA Methylation; D004303:Dosage Compensation, Genetic; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D018895:Microsatellite Repeats / Q000235:genetics; D016133:Polymerase Chain Reaction; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D017422:Sequence Analysis, DNA; D014157:Transcription Factors / Q000235:genetics; D014960:X Chromosome / Q000235:genetics*
D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D014157:Transcription Factors; C077885:XIST non-coding RNA