Amendment to Clinical Research Project. Project 90-C-195. April 1, 1993. Treatment of severe combined immunodeficiency disease (SCID) due to adenosine deaminase deficiency with autologous lymphocytes transduced with a human ADA gene.
Childrens Hospital Los Angeles, U.S.C. School of Medicine, CA 90027, USA.
C
C
Dunbar
L
L
Chang
C
C
Mullen
W J
WJ
Ramsey
C
C
Carter
D
D
Kohn
R
R
Parkman
C
C
Lenarsky
K
K
Weinberg
D
D
Wara
K W
KW
Culver
W F
WF
Anderson
S
S
Leitman
T
T
Fleisher
H
H
Klein
G
G
Shearer
M
M
Clerici
G
G
McGarrity
J
J
Bastian
M S
MS
Hershfield
D000243:Adenosine Deaminase / Q000172:deficiency* / Q000235:genetics*; D018952:Antigens, CD34 / Q000032:analysis; D015139:Blotting, Southern; D001854:Bone Marrow Cells / Q000378:metabolism; D002985:Clinical Protocols; D015316:Genetic Therapy; D006412:Hematopoietic Stem Cells / Q000378:metabolism; D006801:Humans; D007258:Informed Consent; D008214:Lymphocytes / Q000378:metabolism*; D016133:Polymerase Chain Reaction; D011296:Prenatal Diagnosis; D012190:Retroviridae / Q000378:metabolism; D016511:Severe Combined Immunodeficiency / Q000628:therapy*; D014161:Transduction, Genetic; D014182:Transplantation, Autologous
D018952:Antigens, CD34; D000243:Adenosine Deaminase