Control of anesthetic response in C. elegans.
We describe the use of the animal model C. elegans to understand how the volatile anesthetics work at the molecular level. Mutations in several different genes can profoundly change the behavior of this animal under volatile anesthetics. Protein products of two of these genes are discussed. One gene is an integral membrane protein thought to regulate ion channels. The other is a subunit of the first protein complex of the electron transport chain.
University Hospitals of Cleveland, Case Western Reserve University, OH 44106-5007, USA.
B
B
Kayser
S
S
Rajaram
S
S
Thomas
P G
PG
Morgan
M M
MM
Sedensky
D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D017173:Caenorhabditis elegans / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D008957:Models, Genetic
D018685:Anesthetics, Inhalation; D008565:Membrane Proteins