Screening of Korean forest plants for rat lens aldose reductase inhibition.
Naturally occurring substances which can prevent and treat diabetic complications were sought by examining ethanol extracts prepared from Korean forest plants for their inhibitory effects on rat lens aldose reductase activity in vitro. Among the plants examined, Acer ginnala, Illicium religiosum and Cornus macrophylla exerted the most strong inhibitory activity on aldose reductase.
Kim
H Y
HY
Department of Food Chemistry and Biotechnology, Korea Food Research Institute.
Oh
J H
JH
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D003920:Diabetes Mellitus / Q000188:drug therapy; D004353:Drug Evaluation, Preclinical; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007723:Korea; D007908:Lens, Crystalline / Q000201:enzymology*; D019684:Magnoliopsida; D008297:Male; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D014197:Trees
D004791:Enzyme Inhibitors; D010936:Plant Extracts; D000449:Aldehyde Reductase