The volatile anesthetic enflurane activates capacitative Ca2+ channels in rat glioma C6 cells.
(1) The volatile anaesthetics halothane and enflurane released Ca2+ from thapsigargin sensitive stores in rat glioma C6 cells, but only enflurane induced a significant Ca2+ influx. (2) The reason for this can be explained by a different inhibitory effect of the anesthetics on the capacitative Ca2+ influx. (3) Halothane inhibited the capacitative Ca2+ influx with an IC50 of 1.9 vol.%, whereas enflurane only marginally affected the ion flux through the channel.
University of Würzburg, Department of Anaesthesiology, Germany.
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Roewer
D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D000818:Animals; D001932:Brain Neoplasms / Q000378:metabolism*; D002120:Calcium Channel Agonists / Q000494:pharmacology*; D015220:Calcium Channels / Q000187:drug effects*; D004737:Enflurane / Q000494:pharmacology*; D005456:Fluorescent Dyes; D016257:Fura-2; D005910:Glioma / Q000378:metabolism*; D006221:Halothane / Q000494:pharmacology; D051381:Rats; D014407:Tumor Cells, Cultured
D018685:Anesthetics, Inhalation; D002120:Calcium Channel Agonists; D015220:Calcium Channels; D005456:Fluorescent Dyes; D004737:Enflurane; D016257:Fura-2; D006221:Halothane