Molecular genetic approaches to understanding the actin cytoskeleton.
New tools in molecular genetics, such as genetic interaction screens and conditional gene targeting, have advanced the study of actin dynamics in a number of model systems. Yeast, Dictyostelium, Caenorhabditis elegans, Drosophila, and mice have contributed much in recent years to a better understanding of both the numerous functions and modes of regulation of the actin cytoskeleton.
European Molecular Biology Laboratory Mouse Biology Programme via Ramarini 32 00016 Monterotondo Italy. sutherland@embl-monterotondo.it
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D000199:Actins / Q000502:physiology*; D000818:Animals; D017173:Caenorhabditis elegans; D002455:Cell Division / Q000502:physiology; D003285:Contractile Proteins; D003599:Cytoskeleton / Q000502:physiology*; D004023:Dictyostelium; D029721:Drosophila Proteins; D004331:Drosophila melanogaster; D004705:Endocytosis / Q000502:physiology; D018260:Gelsolin / Q000378:metabolism; D005821:Genetic Techniques; D051379:Mice; D008840:Microfilament Proteins / Q000378:metabolism; D009218:Myosins / Q000378:metabolism; D051304:Profilins; D015398:Signal Transduction
D000199:Actins; D003285:Contractile Proteins; D029721:Drosophila Proteins; D018260:Gelsolin; D008840:Microfilament Proteins; D051304:Profilins; C495737:chic protein, Drosophila; D009218:Myosins