Effectors for the Rho GTPases.
The Rho GTPases are simple enzymes with complex roles in regulating cell morphology, gene transcription, cell cycle progression, apoptosis and tumour progression. The picture has been further complicated by the steady rise in the number of known Rho GTPases as well as in the number of known regulators and target proteins of these GTPases. Recent implications of Rho effectors in human disease, however, might give important clues to how specificity is achieved in cell signalling pathways employing Rho GTPases.
Ludwig Institute for Cancer Research Box 595 Biomedical Center S-752 24 Uppsala Sweden. pontus.aspenstrom@LICR.uu.se
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Aspenström
D000199:Actins / Q000378:metabolism; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000378:metabolism; D003599:Cytoskeleton / Q000502:physiology; D020558:GTP Phosphohydrolases / Q000378:metabolism*; D006801:Humans; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D015398:Signal Transduction; D054462:p21-Activated Kinases
D000199:Actins; D018129:Phosphatidylinositol Phosphates; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases; D054462:p21-Activated Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D020558:GTP Phosphohydrolases