Buprenorphine dose self-selection: effects of an alternative reinforcer, behavioral economic analysis of demand, and examination of subjective drug effects.
Buprenorphine (BUP)-maintained patients were first exposed to various BUP doses and then chose between BUP doses and money. In the choice phase, they had 10 units exchangeable for units of BUP (constant at 3 mg/unit) or money (varied from $0.30 to $20/unit). They chose BUP exclusively (30 mg) when the money alternative was low. As available money increased, they selected lower daily BUP doses (down to 3 mg). An economic analysis indicated demand for BUP was inelastic; changes in drug intake were proportionally lower than changes in price. Subjective reports of agonist and withdrawal effects increased > 200% when high and low BUP doses, respectively, were given during the exposure phase. In the choice phase, subjective drug effects were constant regardless of the BUP dose selected. Thus, BUP dose selection varies with the magnitude of alternative reinforcers, and subjective drug effects depend on whether doses are self- or experimenter-selected.
Petry
N M
NM
Department of Psychiatry, University of Vermont, USA. petry@psychiatry.uchc.edu
Bickel
W K
WK
D000328:Adult; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000191:economics* / Q000494:pharmacology*; D001519:Behavior / Q000187:drug effects*; D002047:Buprenorphine / Q000008:administration & dosage / Q000191:economics* / Q000494:pharmacology*; D006801:Humans; D008297:Male; D009293:Opioid-Related Disorders / Q000523:psychology* / Q000652:urine; D012054:Reinforcement, Psychology; D012646:Self Administration; D013375:Substance Withdrawal Syndrome / Q000523:psychology
D000701:Analgesics, Opioid; D002047:Buprenorphine