Amendment to Clinical Research Project. Project 90-C-195. April 1, 1993. Treatment of severe combined immunodeficiency disease (SCID) due to adenosine deaminase deficiency with autologous lymphocytes transduced with a human ADA gene.
Dunbar
C
C
Childrens Hospital Los Angeles, U.S.C. School of Medicine, CA 90027, USA.
Chang
L
L
Mullen
C
C
Ramsey
W J
WJ
Carter
C
C
Kohn
D
D
Parkman
R
R
Lenarsky
C
C
Weinberg
K
K
Wara
D
D
Culver
K W
KW
Anderson
W F
WF
Leitman
S
S
Fleisher
T
T
Klein
H
H
Shearer
G
G
Clerici
M
M
McGarrity
G
G
Bastian
J
J
Hershfield
M S
MS
D000243:Adenosine Deaminase / Q000172:deficiency* / Q000235:genetics*; D018952:Antigens, CD34 / Q000032:analysis; D015139:Blotting, Southern; D001854:Bone Marrow Cells / Q000378:metabolism; D002985:Clinical Protocols; D015316:Genetic Therapy; D006412:Hematopoietic Stem Cells / Q000378:metabolism; D006801:Humans; D007258:Informed Consent; D008214:Lymphocytes / Q000378:metabolism*; D016133:Polymerase Chain Reaction; D011296:Prenatal Diagnosis; D012190:Retroviridae / Q000378:metabolism; D016511:Severe Combined Immunodeficiency / Q000628:therapy*; D014161:Transduction, Genetic; D014182:Transplantation, Autologous
D018952:Antigens, CD34; D000243:Adenosine Deaminase