C1q-binding proteins and C1q receptors.
Aggregated or immobilized complement C1q induces cellular responses in many different cell types. C1q-induced cellular responses may be involved in host defense and in protection against autoimmunity because C1q-deficient humans have infectious complications and a very high incidence of autoimmune disease. The search for the C1q receptor(s), which has been ongoing for 25 years, has led recently to the recognition that proteins identified as binding to C1q may be divided into two groups: C1q-binding molecules that are normally intracellular; and cell surface C1q receptors.
Division of Allergy, Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. anichols@bidmc.harvard.edu.
A
A
Nicholson-Weller
L B
LB
Klickstein
D002352:Carrier Proteins; D015922:Complement C1q / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D018960:Hyaluronan Receptors; D007113:Immunity, Innate; D008562:Membrane Glycoproteins; D024101:Mitochondrial Proteins; D011506:Proteins / Q000276:immunology* / Q000378:metabolism; D011951:Receptors, Complement / Q000276:immunology* / Q000378:metabolism
C087299:C1QBP protein, human; D002352:Carrier Proteins; D018960:Hyaluronan Receptors; D008562:Membrane Glycoproteins; D024101:Mitochondrial Proteins; D011506:Proteins; D011951:Receptors, Complement; C007105:c1q-binding proteins; C032402:complement 1q receptor; D015922:Complement C1q