[Peak pulse blood volume and topical antiglaucoma drugs in rhesus monkeys with experimental open angle glaucoma].
BACKGROUND
The present study was designed to investigate the effect of topical antiglaucoma drugs on Peak Pulse Blood Volume (PPBV; German abbreviation: PGBV) in cynomolgus monkey eyes without (CMNG; German abbreviation: RA-KTL) and with lasersurgically induced glaucoma (CMG; German abbreviation: RA-LHDG).


METHODS
CMG unilaterally received 2-3 laser treatments so as to develop the lasered-eye glaucoma model. Intraocular pressure (IOP; German abbreviation: IOD) and Ocular Pulse Amplitude were measured and PPBV was determined until the glaucoma model had stabilized. Consecutively topical antiglaucoma drugs (epinephrine, paraaminoclonidine, pilocarpine, timolol) were investigated in 4-8 animals in CMNG and CMG eyes.


RESULTS
IOP and PPBV were not significantly altered in CMNG. In the CMG eyes epinephrine and paraaminoclonidine did not significantly alter IOP or PPBV, whereas pilocarpine and timolol sig. (p < 0.01) reduced IOP and significantly (p < 0.05) increased PPBV.


CONCLUSIONS
With respect to improved PPBV in the CMG eye the rank order of drug effectiveness is timolol > pilocarpine > paraaminoclonidine > epinephrine.
Schmidt
K G
KG
Univ.-Augenklinik, Giessen.
von Rückmann
A
A
Eisenmann
D
D
Stegman
D Y
DY
Mittag
T W
TW
D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D001810:Blood Volume / Q000187:drug effects*; D004195:Disease Models, Animal; D005123:Eye / Q000098:blood supply*; D005902:Glaucoma, Open-Angle / Q000188:drug therapy* / Q000209:etiology; D007429:Intraocular Pressure / Q000187:drug effects*; D008252:Macaca fascicularis; D008253:Macaca mulatta; D009883:Ophthalmic Solutions; D011674:Pulse
D000959:Antihypertensive Agents; D009883:Ophthalmic Solutions