Leiomyosarcoma presenting as a mandibular gingival swelling: a case report.
We report a case of primary low-grade leiomyosarcoma of the mandible in an otherwise healthy young woman. The neoplasm presented as a painful, pericoronal gingival swelling that mimicked an acute periodontal infection. It was managed accordingly, with curettage, debridement, and antibiotics. When the lesion failed to respond to this treatment approach, a biopsy was performed. Microscopy revealed a malignant mesenchymal neoplasm which, on immunohistochemistry analysis, demonstrated reactivity for smooth muscle actin (SMA) and vimentin. This established the diagnosis of leiomyosarcoma; subsequently, an en bloc resection of mandibular bone and overlying soft tissue was performed. Close follow-up for over 10 years has revealed no evidence of recurrent or metastatic disease. Since the patient was taking oral contraceptives prior to the onset of the lesion, a possible link between estrogen and smooth muscle tumors is considered.
School of Dental Medicine, University of Connecticut, Farmington, USA.
P R
PR
Goldschmidt
J D
JD
Goldschmidt
S E
SE
Lieblich
E
E
Eisenberg
D000328:Adult; D003276:Contraceptives, Oral / Q000009:adverse effects; D004967:Estrogens / Q000009:adverse effects; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007890:Leiomyosarcoma / Q000737:chemistry / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D008339:Mandibular Neoplasms / Q000737:chemistry / Q000209:etiology / Q000473:pathology* / Q000601:surgery
D003276:Contraceptives, Oral; D004967:Estrogens