[A case of hyalinizing spindle cell tumor with giant rosettes in the presacral region. Immunohistochemical and ultrastructural study].
Hyalinizing spindle cell tumor with giant rosettes is a slowly growing tumor with a risk of local recurrence in case of incomplete surgical excision that could be regarded as a distinctive type of low-grade fibroblastic tumor. We report a case involving the presacral area. This tumor was composed of areas of bland spindle cell proliferation with a fascicular pattern in a fibrous or myxoid stroma, intermixed with giant rosettes consisting of rounded cells surrounding a central collagen core. The tumor expressed vimentin, and, for cells comprising the rosettes, S-100 protein, NSE and CD-57. These latter cells exhibited ultrastructural features of Schwann cells, the tumoral cells of fascicular area exhibiting features of fibroblastic cells. Flow cytometry showed DNA-aneuploidy and a very low S-phase fraction. This tumor appeared to be composed of two cellular components, fibroblastic and Schwann cells, located, at the opposite of neurofibroma, in two distinct areas.
de Pinieux
G
G
Service d'Anatomie Pathologique, Groupe Hospitalier Cochin, Port-Royal, France.
Anract
P
P
le Charpentier
M
M
Carlioz
A
A
Coindre
J M
JM
Vielh
P
P
Tomeno
B
B
Forest
M
M
D000782:Aneuploidy; D018959:CD57 Antigens / Q000032:analysis; D004273:DNA, Neoplasm / Q000032:analysis; D005347:Fibroblasts / Q000473:pathology; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D012447:Sacrum; D012583:Schwann Cells / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000737:chemistry / Q000473:pathology*; D014746:Vimentin / Q000032:analysis
D018959:CD57 Antigens; D004273:DNA, Neoplasm; D009418:S100 Proteins; D014746:Vimentin; D010751:Phosphopyruvate Hydratase