[Chronic inflammatory bowel disease and pregnancy. Case control study].
OBJECTIVE
To evaluate the influence of inflammatory bowel disease on pregnancy and fetal outcome.


METHODS
One hundred and fifty pregnancies in 72 women (28 with ulcerative colitis and 44 with Crohn's disease) were compared with those of 150 control subjects.


RESULTS
Among 150 pregnancies, 108 (group I) began before and 42 (group II) at the same time or after the diagnosis of inflammatory bowel disease. In ulcerative colitis patients, age at first pregnancy, mean birth weight and preterm birth rates were not different between groups I and II; rate of underweight offsprings was significantly higher (P < 0.05) in group II than in group I and controls. In Crohn's disease, compared to group I, mean age of first pregnancy was higher (P < 0.0001), mean birth weight was lower (P < 0.005) and preterm birth rate was higher (P = 0.001) than in group II.


CONCLUSIONS
These results suggest that both ulcerative colitis and Crohn's disease induce deleterious effects on pregnancy and fetal outcome.
Service d'Hépato-Gastroentérologie et Nutrition Artificielle, Hôpital Jean-Bernard, CHU, Poitiers.
I
I
Larzilliere
P
P
Beau
D000328:Adult; D001724:Birth Weight; D016022:Case-Control Studies; D002908:Chronic Disease; D003093:Colitis, Ulcerative / Q000150:complications* / Q000628:therapy; D000013:Congenital Abnormalities / Q000209:etiology; D003424:Crohn Disease / Q000150:complications* / Q000628:therapy; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology; D006760:Hospitalization; D006801:Humans; D008423:Maternal Age; D007752:Obstetric Labor, Premature / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000628:therapy; D011256:Pregnancy Outcome