Synthesis of tetrasubstituted bicyclo[3.2.1]octenes as potential inhibitors of influenza virus sialidase.
Several racemic bicyclo[3.2.1]octene derivatives have been synthesised and evaluated as inhibitors of influenza virus sialidases. The 5-acetamido-bicyclo[3.2.1]octenol 4 showed modest activity against influenza A and B virus sialidases.
Jones
P S
PS
Department of Enzyme Medicinal Chemistry II, Glaxo Wellcome Medicines Research Centre, Stevenage, Herts UK. PSJ3049@GlaxoWellcome.co.uk
Smith
P W
PW
Hardy
G W
GW
Howes
P D
PD
Upton
R J
RJ
Bethell
R C
RC
D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D009980:Influenza A virus / Q000201:enzymology*; D009981:Influenza B virus / Q000201:enzymology*; D009439:Neuraminidase / Q000037:antagonists & inhibitors*
D019086:Bridged Bicyclo Compounds, Heterocyclic; D004791:Enzyme Inhibitors; D009439:Neuraminidase