title: Longitudinal multicentric study of plasma and red blood cell fatty acids and lipids in preterm newborns fed human milk.
abstract: The present multicentric study (three centers) deals with the values of plasma and red blood cell fatty acids obtained in a group of 18 preterm newborns after 2 days (D2), 15 days (D15) and 5 weeks (37th week postconception: 37th wk) of human milk feeding. Analytical methods were randomized between the three centers and quality control was evaluated by repeated analysis of reference samples. 20:4 n-6 varied from 10.71 +/- 1.58% to 9.51 +/- 1.65 and 10.10 +/- 1.42% in plasma phospholipids and from 16.59 +/- 3.30% to 14.68 +/- 3.14 and 18.24 +/- 4.09% in red blood cell phosphatidylethanolamine (RBC-PE) at D2, D15 and 37th wk, respectively, contrasting with the important rise of the precursor (18:2 n-6) in all the fractions studied. In RBC-PE, 22:6 n-3 significantly declined from 3.52 +/- 1. 03% at D2 to 2.56 +/- 0.83% at D15 (p < 0.02) and recovered its initial level at 37th wk (4.08 +/- 1.94%). The recovery of long chain polyunsaturated fatty acid homeostasis at that time was also confirmed by the decline of 16:1 n-7 in cholesterol esters (10.69 +/- 3.92 to 4.32 +/- 2.38%).
authors: Laboratoire de Biologie et Biochimie des Lipides, Université, Montpellier I, France.
authors: F
authors: F
authors: Babin
authors: P
authors: P
authors: Sarda
authors: D
authors: D
authors: Bouglé
authors: C
authors: C
authors: Billeaud
authors: S
authors: S
authors: Mazette
authors: N
authors: N
authors: Combe
authors: A
authors: A
authors: Nouvelot
authors: B
authors: B
authors: Descomps
authors: B
authors: B
authors: Entressangles
authors: A
authors: A
authors: Crastes de Paulet
authors: F
authors: F
authors: Mendy
mesh_terms: D002784:Cholesterol / Q000097:blood; D004912:Erythrocytes / Q000378:metabolism*; D005227:Fatty Acids / Q000097:blood*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008137:Longitudinal Studies; D008895:Milk, Human; D010714:Phosphatidylethanolamines / Q000097:blood; D011786:Quality Control; D012016:Reference Values; D014280:Triglycerides / Q000097:blood
chemical_list: D005227:Fatty Acids; D008055:Lipids; D010714:Phosphatidylethanolamines; D014280:Triglycerides; D002784:Cholesterol