Grape polyphenols protect neurodegenerative changes induced by chronic ethanol administration.
Increased oxidative stress in the brain due to chronic ethanol consumption is known to result in a number of neurodegenerative changes. This study was designed to test whether dietary supplementation of grape polyphenols (GP) can offer protection to the neurodegenerative changes resulting from chronic ethanol consumption. Sprague-Dawley rats were fed a Leiber-DeCarli liquid diet with ethanol or isocaloric amount of maltose, and with or without GP for 2 months. Chronic ethanol caused significant decreases in synaptosomal Na,K-ATPase (20.5%) and dopamine uptake (22.8%) activities compared with pair-fed controls. Although GP alone did not alter activities of these membrane-bound proteins, GP supplementation was able to completely protect the decrease in synaptic protein function elicited by chronic ethanol consumption.
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Department of Biochemistry, University of Missouri, Columbia 65212, USA.
Xia
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Draczynska-Lusiak
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B
Simonyi
A
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Sun
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D000437:Alcoholism / Q000150:complications*; D000704:Analysis of Variance; D000818:Animals; D005419:Flavonoids; D008297:Male; D008565:Membrane Proteins / Q000187:drug effects; D009410:Nerve Degeneration / Q000517:prevention & control*; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D010636:Phenols / Q000627:therapeutic use*; D011108:Polymers / Q000627:therapeutic use*; D059808:Polyphenols; D051381:Rats; D017207:Rats, Sprague-Dawley; D013570:Synaptic Membranes / Q000187:drug effects
D005419:Flavonoids; D008565:Membrane Proteins; D018696:Neuroprotective Agents; D010636:Phenols; D011108:Polymers; D059808:Polyphenols