[Dysfunction of cadherin cell adhesion system in cancer invasion and metastasis].
Dysfunction of the cadherin-mediated cell adhesion system involved in cancer metastasis occurs by several mechanisms: alterations of E-cadherin, alpha- and beta-catenin genes, CpG methylation of the promoter region of E-cadherin, and aberrant tyrosine phosphorylation of beta-catenin. In addition to the cell adhesion function, beta-catenin, which is an intracytoplasmic cadherin binding molecule and thought to be a regulator of cadherin-mediated cell adhesion function, has been proven to associate with both the growth factor receptors, including c-erbB-2, EGF receptor and k-sam and APC tumor suppressor gene product. These data indicate that the cadherin-mediated cell adhesion system plays important roles not only in cancer metastasis but in carcinogenesis.
Ochiai
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Pathology Division, National Cancer Center Research Institute East.
D000230:Adenocarcinoma / Q000737:chemistry / Q000556:secondary; D015820:Cadherins / Q000502:physiology*; D002448:Cell Adhesion / Q000502:physiology; D003598:Cytoskeletal Proteins / Q000235:genetics; D006801:Humans; D009361:Neoplasm Invasiveness / Q000473:pathology*; D009362:Neoplasm Metastasis / Q000473:pathology*; D015398:Signal Transduction; D013274:Stomach Neoplasms / Q000737:chemistry / Q000473:pathology; D015534:Trans-Activators; D051178:alpha Catenin; D051176:beta Catenin
C495273:CTNNA1 protein, human; C495270:CTNNB1 protein, human; D015820:Cadherins; D003598:Cytoskeletal Proteins; D015534:Trans-Activators; D051178:alpha Catenin; D051176:beta Catenin