title: It's a noisy business! Genetic regulation at the nanomolar scale.
abstract: Many molecules that control genetic regulatory circuits act at extremely low intracellular concentrations. Resultant fluctuations (noise) in reaction rates cause large random variation in rates of development, morphology and the instantaneous concentration of each molecular species in each cell. To achieve regulatory reliability in spite of this noise, cells use redundancy in genes as well as redundancy and extensive feedback in regulatory pathways. However, some regulatory mechanisms exploit this noise to randomize outcomes where variability is advantageous.
authors: Department of Developmental Biology, School of Medicine, Stanford University, CA 94305, USA. mcadams@cmgm.stanford.edu
authors: H H
authors: HH
authors: McAdams
authors: A
authors: A
authors: Arkin
mesh_terms: D018407:Bacterial Physiological Phenomena; D002468:Cell Physiological Phenomena; D005057:Eukaryotic Cells / Q000502:physiology; D005658:Fungi / Q000502:physiology; D005786:Gene Expression Regulation / Q000502:physiology*; D007700:Kinetics; D046911:Macromolecular Substances; D008832:Microchemistry; D008954:Models, Biological; D009994:Osmolar Concentration; D010641:Phenotype; D011897:Random Allocation; D013269:Stochastic Processes
chemical_list: D046911:Macromolecular Substances