Inhibition of the emergence of ciprofloxacin resistance in Streptococcus pneumoniae by the multidrug efflux inhibitor reserpine.
Recent evidence supports the contribution of a multidrug efflux mechanism to fluoroquinolone resistance in Streptococcus pneumoniae. In this paper I show that reserpine, an inhibitor of multidrug transporters in gram-positive bacteria, dramatically suppresses the in vitro emergence of ciprofloxacin-resistant variants of S. pneumoniae, suggesting that the combination of a fluoroquinolone with an inhibitor of multidrug transport may help preserve the efficacy of this class of antibiotics.
Markham
P N
PN
Influx, Inc., Chicago, Illinois 60612, USA. pmarkham@uic.edu
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000037:antagonists & inhibitors*; D000890:Anti-Infective Agents / Q000494:pharmacology; D002939:Ciprofloxacin / Q000494:pharmacology*; D004347:Drug Interactions; D004352:Drug Resistance, Microbial / Q000502:physiology; D008826:Microbial Sensitivity Tests; D012110:Reserpine / Q000494:pharmacology*; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000502:physiology
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000890:Anti-Infective Agents; D002939:Ciprofloxacin; D012110:Reserpine