An integrated map of chromosome 18 CAG trinucleotide repeat loci.
Expansions of trinucleotide CAG repeats have been demonstrated in at least eight neurodegenerative disorders, and suggested to occur in several others, including bipolar disorder and schizophrenia. Chromosome 18 loci have been implicated in bipolar disorder pedigrees by linkage analysis. To address this putative link between chromosome 18 CAG trinucleotide repeats and neuropsychiatric illness, we have screened a chromosome 18 cosmid library (LL18NCO2" AD") and identified 14 novel candidate loci. Characterisation of these loci involved repeat flank sequencing, estimation of polymorphism frequency and mapping using FISH as well as radiation hybrid panels. These mapped trinucleotide loci will be useful in the investigation of chromosome 18 in neurodegenerative or psychiatric conditions, and will serve to integrate physical and radiation hybrid maps of chromosome 18.
Grierson
A J
AJ
Department of Neurology, University of Amsterdam, Academic Medical Center, The Netherlands.
van Groenigen
M
M
Groot
N P
NP
Lindblad
K
K
Hoovers
J M
JM
Schalling
M
M
de Belleroche
J
J
Baas
F
F
D001483:Base Sequence; D002874:Chromosome Mapping; D002887:Chromosomes, Human, Pair 18; D017931:DNA Primers; D006801:Humans; D006822:Hybrid Cells; D001523:Mental Disorders / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid; D016324:Sequence Tagged Sites; D018911:Trinucleotide Repeats
D017931:DNA Primers