Bilateral basal ganglial necrosis after allogeneic bone marrow transplantation in a child with Kostmann syndrome.
A 6-year-old girl underwent allogeneic BMT from a matched sibling donor for the treatment of Kostmann syndrome. She suddenly became drowsy on day 30 after BMT, and lost consciousness 2 days later. Cranial CT scan showed symmetrical lesions suggesting bilateral necrosis in the basal ganglia. Clinical and laboratory investigations failed to reveal any evidence of neurometabolic disease.
Suga
N
N
Section of Pediatrics, National Kyushu Cancer Center, Fukuoka, Japan.
Nagatoshi
Y
Y
Gondou
K
K
Kira
R
R
Ikuno
Y
Y
Okamura
J
J
D001479:Basal Ganglia / Q000473:pathology*; D001480:Basal Ganglia Diseases / Q000209:etiology / Q000473:pathology; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002648:Child; D005260:Female; D006801:Humans; D009336:Necrosis; D009503:Neutropenia / Q000151:congenital / Q000628:therapy*; D013577:Syndrome; D014184:Transplantation, Homologous