Homoisofagomines: chemical-enzymatic synthesis and evaluation as alpha- and beta-glucosidase inhibitors.
Methyl- and hydroxymethyl derivatives of the highly potent glycosidase inhibitor isofagomine are accessible via aldolase-catalyzed C-C bond formation and competitively inhibit beta-glucosidase at low micromolar concentrations.
Schuster
M
M
Institut für Organische Chemie, Technische Universität Berlin, Germany. paul@wap0105.chem.tu-berlin.de
D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D065089:Glycoside Hydrolase Inhibitors; D015394:Molecular Structure; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001617:beta-Glucosidase / Q000037:antagonists & inhibitors*
D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D010880:Piperidines; D001617:beta-Glucosidase