Genus specific neutralization of Bungarus snake venoms by Thai Red Cross banded krait antivenom.
Thai commercial antivenom raised to Bungarus fasciatus venom neutralized the lethal activity of all Thai Bungarus venoms tested in in vitro neutralization experiments. The neutralizing capacities against B. fasciatus and B. candidus venoms were almost the same, but that against B. flaviceps venom was significantly greater. The efficacy of the antivenom was confirmed in in vivo neutralization experiments also. Results of immunochemical analyses supported results of the animal experiments suggesting the presence of genus specific neutralization.
Chanhome
L
L
Queen Saovabha Memorial Institute, Thai Red Cross Society, Bangkok, Thailand.
Wongtongkam
N
N
Khow
O
O
Pakmanee
N
N
Omori-Satoh
T
T
Sitprija
V
V
D000818:Animals; D000997:Antivenins / Q000737:chemistry*; D002038:Bungarotoxins / Q000737:chemistry / Q000633:toxicity*; D017838:Bungarus / Q000235:genetics* / Q000502:physiology*; D004347:Drug Interactions; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D015151:Immunoblotting; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D012910:Snake Venoms / Q000737:chemistry* / Q000633:toxicity; D013045:Species Specificity
D000997:Antivenins; D002038:Bungarotoxins; D012910:Snake Venoms