title: Oxidative stress in newborn infants with and without asphyxia as measured by plasma antioxidants and free fatty acids.
abstract: A rapid perfusion of oxygen in infants at birth may cause an increase of oxidative stress. To assess this possibility, we measured levels of blood plasma antioxidants and free fatty acids in 20 normal infants at 0, 1, 3, and 5 days after birth. Plasma levels of the most reactive antioxidant, ascorbic acid, decreased daily to equilibrium values at days 3 and 5. Percentages of oxidized form of coenzyme Q-10 (%CoQ-10) in total coenzyme Q, another good marker of oxidative stress, in infants (25-31%) were significantly higher than those in healthy young adults (4.5%). Plasma levels of total free fatty acids (FFA) in normal infants were highest at day 1 and decreased rapidly thereafter. The content of polyunsaturated fatty acids (PUFA) in total FFA was lowest at day 1 and then increased. Since PUFA are susceptible to oxidation, these changes in FFA composition suggest that oxidative stress is most evident at the initial day of neonatal life. Furthermore, it appears that mono-unsaturated fatty acids such as oleic and palmitoleic acids increase in response to the oxidative loss of PUFA. Similar changes in plasma antioxidants, FFA levels, and FFA compositions were observed in 9 infants with asphyxia. Values of %CoQ-10 in infants with asphyxia were significantly greater than those in normal infants, suggesting that infants with asphyxia have elevated oxidative stress.
authors: Department of Pediatrics, Oita Medical University, 1-1 Idaigaoka, Hasama, Oita, 879-5593, Japan.
authors: K
authors: K
authors: Hara
authors: S
authors: S
authors: Yamashita
authors: A
authors: A
authors: Fujisawa
authors: S
authors: S
authors: Ishiwa
authors: T
authors: T
authors: Ogawa
authors: Y
authors: Y
authors: Yamamoto
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D001205:Ascorbic Acid / Q000097:blood; D001238:Asphyxia Neonatorum / Q000097:blood*; D001663:Bilirubin / Q000097:blood; D003067:Coenzymes; D005227:Fatty Acids / Q000097:blood* / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000097:blood; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D013997:Time Factors; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism; D014527:Uric Acid / Q000097:blood; D014810:Vitamin E / Q000097:blood
chemical_list: D000975:Antioxidants; D003067:Coenzymes; D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D014451:Ubiquinone; D014810:Vitamin E; D014527:Uric Acid; C026663:ubiquinol-10; C024989:coenzyme Q10; D001205:Ascorbic Acid; D001663:Bilirubin