Nucleomimetic strategy for the inhibition of HIV-1 nucleocapsid protein NCp7 activities.
We report the synthesis and biological properties of three modified dinucleotides T*G, G*T and T*T in which the natural phosphodiester linkage has been replaced by a methylene carboxamide unit. They have been designed to act as nucleomimetics of a sequence recognized by the HIV-1 nucleocapsid protein NCp7 and to inhibit this interaction.
Druillennec
S
S
Département de Pharmacochimie Moléculaire et Structurale INSERM U266-CNRS UMR 8600 UFR des Sciences Pharmaceutiques et Biologiques, Paris, France.
Meudal
H
H
Roques
B P
BP
Fournié-Zaluski
M C
MC
D002213:Capsid / Q000037:antagonists & inhibitors*; D036022:Capsid Proteins; D019281:Dimerization; D015683:Gene Products, gag / Q000037:antagonists & inhibitors*; D006860:Hydrogen Bonding; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D018716:Molecular Mimicry; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014764:Viral Proteins; D054301:gag Gene Products, Human Immunodeficiency Virus
D036022:Capsid Proteins; D015683:Gene Products, gag; C071884:NCP7 protein, Human immunodeficiency virus 1; D009841:Oligonucleotides; D014764:Viral Proteins; D054301:gag Gene Products, Human Immunodeficiency Virus