title: Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) encodes a homologue of the Epstein-Barr virus bZip protein EB1.
abstract: Analysis of the recently completed genomic sequence of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) revealed that ORF 50 encodes a protein with homology to the Epstein-Barr virus (EBV) transcription factor R. In this report, we show that ORF K8, contiguous to ORF 50, is interrupted by two introns and that the spliced RNA is translated into a bZip protein that has homology to the EBV transcription factor EB1. The newly characterized K8 protein forms homodimers but does not heterodimerize with other members of the bZip protein family.
authors: H
authors: H
authors: Gruffat
authors: S
authors: S
authors: Portes-Sentis
authors: A
authors: A
authors: Sergeant
authors: E
authors: E
authors: Manet
mesh_terms: D000595:Amino Acid Sequence; D050976:Basic-Leucine Zipper Transcription Factors; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D002460:Cell Line; D017931:DNA Primers; D004268:DNA-Binding Proteins / Q000096:biosynthesis / Q000737:chemistry* / Q000235:genetics; D019281:Dimerization; D004854:Herpesvirus 4, Human / Q000235:genetics*; D019288:Herpesvirus 8, Human / Q000235:genetics* / Q000254:growth & development; D006801:Humans; D007438:Introns / Q000235:genetics; D016350:Leucine Zippers; D008969:Molecular Sequence Data; D016366:Open Reading Frames / Q000235:genetics; D011233:Precipitin Tests; D011485:Protein Binding; D014176:Protein Biosynthesis; D012326:RNA Splicing / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011993:Recombinant Fusion Proteins / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D012097:Repressor Proteins; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017384:Sequence Deletion; D017386:Sequence Homology, Amino Acid; D015534:Trans-Activators / Q000096:biosynthesis / Q000737:chemistry* / Q000235:genetics; D014764:Viral Proteins / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism
chemical_list: C063676:BZLF1 protein, Herpesvirus 4, Human; D050976:Basic-Leucine Zipper Transcription Factors; D002352:Carrier Proteins; D017931:DNA Primers; D004268:DNA-Binding Proteins; C118265:K8 protein, Human herpesvirus 8; D012333:RNA, Messenger; D011993:Recombinant Fusion Proteins; D012097:Repressor Proteins; D015534:Trans-Activators; D014764:Viral Proteins