Eicosatrienoic acid (20:3 n-9) inhibits the expression of E-cadherin and desmoglein in human squamous cell carcinoma in vitro.
Eicosatrienoic acid (ETA 5,8,11, n-9) is abnormally increased by essential fatty acid deficiency (EFAD), a condition associated with alterations of cell proliferation and differentiation. In comparison to certain EFAs, addition of ETA at a low concentration resulted in a reduction in the expression of the cell-cell adhesion molecule, E-cadherin, and to a lesser degree, of desmoglein, along with increased invasion of Matrigel by human squamous cell carcinoma (SCC) cells in vitro. At higher concentrations, ETA stimulated the growth of SCC cells. As previously shown, n-6 EFAs (mainly 18:3 n-6, GLA), up-regulated the expression of E-cadherin and desmoglein. This is the first report showing that the abnormal 20:3 n-9 (Mead's acid) is a down regulator of antimetastatic E-cadherin and desmoglein expression.
Eynard
A R
AR
Instituto de Biologia Celular, Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, Argentina. aeynard@cmefcm.uncor.edu
Jiang
W G
WG
Mansel
R E
RE
D015126:8,11,14-Eicosatrienoic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D006690:Bisbenzimidazole / Q000378:metabolism; D015153:Blotting, Western; D015820:Cadherins / Q000276:immunology / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D015815:Cell Adhesion Molecules; D002455:Cell Division; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D051182:Desmogleins; D051180:Desmoplakins; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007150:Immunohistochemistry; D014407:Tumor Cells, Cultured; D017965:gamma-Linolenic Acid / Q000378:metabolism
D015820:Cadherins; D015815:Cell Adhesion Molecules; D003598:Cytoskeletal Proteins; D051182:Desmogleins; D051180:Desmoplakins; D017965:gamma-Linolenic Acid; D015126:8,11,14-Eicosatrienoic Acid; C010944:mead acid; D006690:Bisbenzimidazole