title: Sibutramine produces dose-related weight loss.
abstract: OBJECTIVE
  Sibutramine is a weight control drug that inhibits the reuptake of both serotonin and norepinephrine. In animals, it reduces food intake and increases thermogenesis and preliminary data in human beings showed weight loss. This paper reports a 24-week dose-ranging study to determine the effect of sibutramine on body weight of patients with obesity.
  
  
  METHODS
  Seven clinical centers screened 1463 patients with obesity and randomized 1047 to 24 weeks of treatment with 1 of 6 doses of sibutramine (1, 5, 10, 15, 20, or 30 mg) or placebo once daily. Six hundred eighty-three patients completed the study. A two-week placebo run-in period was used to initiate a standardized program of diet, physical activity, and lifestyle changes.
  
  
  RESULTS
  Weight loss was dose-related and statistically significant vs. placebo (p<0.05) across all time-points for a 5 mg/day to 30 mg/day dosage of sibutramine. At week 24, percent weight loss from baseline for completers was: placebo, 1.2%; 1 mg, 2.7%; 5 mg, 3.9%; 10 mg, 6.1%; 15 mg, 7.4%; 20 mg, 8.8%; and 30 mg, 9.4%. Weight loss achieved at week 4 was predictive of weight loss achieved at week 24. Patients losing weight demonstrated an increase in serum high density lipoprotein cholesterol and reductions in serum triglycerides, total cholesterol, low density lipoprotein cholesterol, and uric acid. Small mean increases in blood pressure and pulse rate (with considerable individual variability) were observed in patients treated with sibutramine. The most frequent adverse events were dry mouth, anorexia, and insomnia.
  
  
  CONCLUSIONS
  Sibutramine administered once daily for 24 weeks in the weight loss phase of treatment for uncomplicated obesity produced dose-related weight loss and was well tolerated. Improvements in serum lipids and uric acid accompany sibutramine-induced weight loss. Most of the adverse events observed on sibutramine are related to its pharmacology, including small mean increases in blood pressure and heart rate.
authors: Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA. brayga@mhs.pbrc.edu
authors: G A
authors: GA
authors: Bray
authors: G L
authors: GL
authors: Blackburn
authors: J M
authors: JM
authors: Ferguson
authors: F L
authors: FL
authors: Greenway
authors: A K
authors: AK
authors: Jain
authors: C M
authors: CM
authors: Mendel
authors: J
authors: J
authors: Mendels
authors: D H
authors: DH
authors: Ryan
authors: S L
authors: SL
authors: Schwartz
authors: M L
authors: ML
authors: Scheinbaum
authors: T B
authors: TB
authors: Seaton
mesh_terms: D000328:Adult; D001067:Appetite Depressants / Q000008:administration & dosage / Q000627:therapeutic use*; D001794:Blood Pressure; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003503:Cyclobutanes / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000188:drug therapy*; D010919:Placebos; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D015431:Weight Loss
chemical_list: D001067:Appetite Depressants; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D003503:Cyclobutanes; D010919:Placebos; D014280:Triglycerides; D002784:Cholesterol; C058254:sibutramine