Strong expression of glutathione S-transferase placental form in early preneoplastic lesions and decrease with progression in hamster buccal pouch carcinogenesis.
The objective of this work was to investigate the expression of glutathione S-transferase placental form (GST-P) in 9,10-dimethyl-1,2-benzanthracene (DMBA)-induced hamster buccal pouch carcinogenesis. Lesions were classified histopathologically into four categories, simple hyperplasia, papillary and nodular (PN) hyperplasia, papilloma and squamous cell carcinoma (SCC). Respective mean percentage GST-P positive areas were 81.6 +/- 7.3%, 76.1 +/- 7.3%, 25.8 +/- 4.9% and 1.9 +/- 1.2%, with significant (P < 0.001) differences confirmed between each of the lesions. These results indicate that GST-P is a useful positive marker for neoplastic lesions and that a decreased expression occurs with progression so that it may be predictive of future development of malignancy.
Iida
K
K
Aichi Cancer Center Research Institute, The First Department of Oral and Maxillofacial Surgery, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan.
Yamamoto
M
M
Kato
M
M
Yoshida
K
K
Kurita
K
K
Tatematsu
M
M
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002273:Carcinogens; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000201:enzymology / Q000473:pathology; D002455:Cell Division; D002610:Cheek; D006224:Cricetinae; D018450:Disease Progression; D005982:Glutathione Transferase / Q000378:metabolism*; D006965:Hyperplasia / Q000139:chemically induced / Q000201:enzymology / Q000473:pathology; D008297:Male; D008647:Mesocricetus; D009061:Mouth Mucosa / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D009062:Mouth Neoplasms / Q000139:chemically induced / Q000201:enzymology* / Q000473:pathology; D010212:Papilloma / Q000139:chemically induced / Q000201:enzymology / Q000473:pathology; D011230:Precancerous Conditions / Q000139:chemically induced / Q000201:enzymology* / Q000473:pathology
D014408:Biomarkers, Tumor; D002273:Carcinogens; D015127:9,10-Dimethyl-1,2-benzanthracene; D005982:Glutathione Transferase