Dietary curcumin with cisplatin administration modulates tumour marker indices in experimental fibrosarcoma.
Curcumin, the active constituent of Curcuma longa, which itself possesses antitumour activity against experimental tumours, enhances the antitumour effect of the widely used anticancer drug cisplatin, when used in combination against fibrosarcoma. Tumour marker enzymes such as aminotransferases, lactate dehydrogenase, gamma-glutamyl transpeptidase, alkaline phosphatase, 5'-nucleotidase were analysed in liver and kidney homogenates of experimental rats. All these enzyme activities were markedly increased in tumour bearing animals. On cisplatin administration, the enzyme levels were decreased but not to near normal values. Curcumin, when treated along with cisplatin brought back the enzyme levels to near the control values. Thus curcumin and cisplatin combination may be worth trying against tumours like fibrosarcoma.
Navis
I
I
Departmant of Madical Biochemistry, University of Madras, Taramani Campus, Chennai, 600 113, India.
Sriganth
P
P
Premalatha
B
B
D000704:Analysis of Variance; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002945:Cisplatin / Q000008:administration & dosage; D003474:Curcumin / Q000008:administration & dosage / Q000627:therapeutic use*; D004032:Diet; D004354:Drug Screening Assays, Antitumor; D005354:Fibrosarcoma / Q000139:chemically induced / Q000188:drug therapy* / Q000201:enzymology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012680:Sensitivity and Specificity
D014408:Biomarkers, Tumor; D003474:Curcumin; D002945:Cisplatin