title: Intracranial pressure during liver transplantation for fulminant hepatic failure.
abstract: During orthotopic liver transplantation (OLT) for fulminant hepatic failure (FHF), some patients develop cerebral injury secondary to intracranial hypertension. We monitored intracranial pressure (ICP) and cerebral perfusion pressure (CPP) before and during OLT in 12 FHF patients undergoing transplantation. All four patients who had normal ICP preoperatively maintained normal ICP/CPP throughout OLT. During OLT, four of the eight patients with pretransplant intracranial hypertension had six episodes of ICP increase. These episodes of intracranial hypertension occurred during failing liver dissection (n=3) and graft reperfusion (n=3). At the end of the anhepatic phase, the ICP was lower than the preoperative ICP in all patients, and was below 15 mmHg in all but one patient. These data suggest that in FHF patients who develop intracranial hypertension before OLT, dissection of the native liver and graft reperfusion are associated with a risk of brain injury resulting from intracranial hypertension and cerebral hypoperfusion.
authors: Department of Surgery, Cedars Sinai Medical Center UCLA School of Medicine, Los Angeles, California 90048, USA.
authors: O
authors: O
authors: Detry
authors: N
authors: N
authors: Arkadopoulos
authors: P
authors: P
authors: Ting
authors: E
authors: E
authors: Kahaku
authors: J
authors: J
authors: Margulies
authors: W
authors: W
authors: Arnaout
authors: S D
authors: SD
authors: Colquhoun
authors: J
authors: J
authors: Rozga
authors: A A
authors: AA
authors: Demetriou
mesh_terms: D000328:Adult; D001929:Brain Edema / Q000209:etiology; D002648:Child; D005260:Female; D006501:Hepatic Encephalopathy / Q000628:therapy*; D006801:Humans; D019586:Intracranial Hypertension / Q000209:etiology*; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged