Dietary and genetic interactions in the regulation of plasma lipoprotein(a).
Lipoprotein(a) is a plasma particle which is considered to be a risk factor for the development of coronary heart disease. Plasma levels of lipoprotein(a) are affected by different types of dietary fat and steroid hormones. Two regions upstream of the apolipoprotein(a) promoter have been isolated which could be the site of regulation of apolipoprotein(a) gene transcription.
Puckey
L
L
Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, UK.
Knight
B
B
D003327:Coronary Disease / Q000097:blood; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood* / Q000235:genetics; D010958:Plasminogen / Q000235:genetics; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D012307:Risk Factors
D004042:Dietary Fats, Unsaturated; D017270:Lipoprotein(a); D010958:Plasminogen