The radiobiology of radiosurgery.
Radiosurgery is the precise and complete destruction of a chosen target containing healthy or pathological cells, without significant concomitant or late radiation damage to adjacent cells. This article discusses briefly the many uses of radiobiology and considers variables in the treatment, such as dose rate, dose homogeneity, and the issue of possible pharmacological radioprotection for radiosurgery. Comparisons between radiosurgery and fractionation are also made.
Kondziolka
D
D
Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213-2582, USA.
Lunsford
L D
LD
Flickinger
J C
JC
D001921:Brain / Q000528:radiation effects*; D001927:Brain Diseases / Q000532:radiotherapy / Q000601:surgery*; D001932:Brain Neoplasms / Q000532:radiotherapy / Q000601:surgery; D002560:Cerebrovascular Circulation / Q000528:radiation effects; D019583:Dose Fractionation, Radiation; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000601:surgery; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000517:prevention & control; D011837:Radiation-Protective Agents / Q000627:therapeutic use; D016634:Radiosurgery / Q000009:adverse effects / Q000379:methods*
D011837:Radiation-Protective Agents