Integron-mediated rifampin resistance in Pseudomonas aeruginosa.
A new rifampin resistance gene, arr-2, has been found in Pseudomonas aeruginosa. The ARR-2 protein shows 54% amino acid identity to the rifampin ADP-ribosylating transferase encoded by the arr gene from Mycobacterium smegmatis. This arr-2 gene is located on a gene cassette within a class I integron.
Tribuddharat
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Department of Microbiology and Immunology, Finch University of the Health Sciences, Chicago Medical School, Illinois 60064, USA.
Fennewald
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D000595:Amino Acid Sequence; D000904:Antibiotics, Antitubercular / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics*; D001483:Base Sequence; D004269:DNA, Bacterial / Q000032:analysis; D004352:Drug Resistance, Microbial / Q000235:genetics; D006801:Humans; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D020102:Mycobacterium smegmatis / Q000235:genetics; D011550:Pseudomonas aeruginosa / Q000235:genetics*; D012293:Rifampin / Q000494:pharmacology; D017386:Sequence Homology, Amino Acid
C119094:ARR-2 protein, Bacteria; C492263:ARR-2 protein, Pseudomonas aeruginosa; D000904:Antibiotics, Antitubercular; D001426:Bacterial Proteins; D004269:DNA, Bacterial; D012293:Rifampin