Multifocal fibrosclerosis presenting as Grave's orbitopathy. Bilateral exophthalmos associated with retroperitoneal and sellar fibrosis.
BACKGROUND
Multifocal fibrosclerosis (MF) is a rare disease that may be misdiagnosed as Graves' orbitopathy. The combination of localisations of MF presented here has not been reported before.


METHODS
A 44-year-old man was referred with progressive bilateral exophthalmos. CT of his chest and abdomen revealed an intrathoracic and retroperitoneal peri-aortal soft-tissue process with hydronephrosis. Histological examination of orbital masses showed a fibrous process with low inflammatory activity. Later the sella was found to be involved as well. A diagnosis of MF was made.


CONCLUSIONS
MF should be considered in the differential diagnosis of bilateral exophthalmos.
van der Pol
R
R
Department of Ophthalmology, University Hospital Utrecht, The Netherlands.
Nieuwenhuis
M G
MG
Mourits
M P
MP
D000328:Adult; D001927:Brain Diseases / Q000150:complications / Q000175:diagnosis*; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D005094:Exophthalmos / Q000150:complications / Q000175:diagnosis*; D005500:Follow-Up Studies; D006111:Graves Disease / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009915:Orbit / Q000000981:diagnostic imaging / Q000473:pathology; D012185:Retroperitoneal Fibrosis / Q000150:complications / Q000175:diagnosis*; D012658:Sella Turcica / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed