Influence of caesarean delivery and maternal factors on fat-soluble vitamins in blood from cord and neonates.
We measured plasma and erythrocyte vitamin E (VE) and plasma vitamin A (VA) profiles in 48 full-term and 8 preterm pairs of neonates and their mothers at birth and we determined whether there is any relationship between maternal and umbilical cord for the nutrients measured. At the same time, we assessed the influence of the delivery type and neonate anthropometric measurements on maternal and cord blood VA and VE levels. We measured vitamin levels in vein and arterial blood in order to establish differences due to fetal metabolism. To determine the influence of pregnancy on vitamin levels, we compared the maternal results with data from a group of 13 non-pregnant women. Cord blood had lower plasma VE (arterial 275.8+/-71.7 microg/dl and vein 282.89+/-64.4 microg/dl values), erythrocyte VE (arterial 256.96+/-50.41 microg/dl packet cells and vein 257.41+/-44.35 microg/dl values), and VA levels (arterial 26.72+/-11.83 microg/dl and 27.15+/-10.05 microg/dl values) and a lower vitamin E/total lipids ratio (VE/LT) (arterial 1.60+/-0.4 and vein 1.62+/-0.3 values) than maternal blood (1474.62+/-424.51 microg/dl, 305.94+/-54.75 microg/dl packet cells, 41.03+/-18.83 microg/dl, 2.34+/-0.5, respectively). VA levels were higher in preterm than full-term neonates (P<0.05). Plasma and erythrocyte VE levels were not correlated in maternal blood but were correlated in neonates and infants (r>0.40; P<0.01). We found a good correlation between erythrocyte tocopherol of maternal and cord blood (r>0.40; P<0.01), although there was no correlation with plasma VE values. Cord vein plasma VE levels were higher than cord arterial blood measurements (P<0.01). The plasma VE and VE/LT of the mother and cord following vaginal delivery were higher than measurements from caesarean delivery (P<0.05), although erythrocyte levels were similar. The plasma VE level was higher in mothers at delivery than non-pregnant women.
González-Corbella
M J
MJ
Food Sciences and Nutrition Unit - CERTA, Faculty of Pharmacy, University of Barcelona, Spain. mjgonzal@farmacia.far.ub.es
López-Sabater
M C
MC
Castellote-Bargalló
A I
AI
Campoy-Folgoso
C
C
Rivero-Urgell
M
M
D000328:Adult; D002585:Cesarean Section; D004912:Erythrocytes / Q000737:chemistry; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006400:Hematocrit; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D008297:Male; D008423:Maternal Age; D010298:Parity; D011247:Pregnancy; D012727:Sex Characteristics; D014801:Vitamin A / Q000097:blood*; D014810:Vitamin E / Q000097:blood*
D014801:Vitamin A; D014810:Vitamin E