title: Trichinella spiralis: the infectivity of synchronous newborn larvae of different ages inoculated intraocularly.
abstract: Trichinella spiralis infection results in the transformation of muscle cells into a new, non-muscular cell called the nurse cell, and the nurse cell-muscle larva complex is finally created. To investigate whether T. spiralis infectivity is NBL age-dependent, five groups of synchronous newborn larvae (sNBL) were obtained at 1, 9, 24, 48, and 72 h of age and were inoculated into mice by intravenous injection into the retro-orbital venous plexus. When both "young" groups of sNBL (1 and 9 h old) were injected, the highest number of larvae were capable of infecting the muscle cells. The highest infectivity of 80.0 % was observed for 9-h-old sNBL. In older sNBL the infectivity gradually decreased; thus, for 72-h-old sNBL the lowest level - 0.1% - was detected. Therefore, an "age limit" for NBL infectivity in the present study was precisely determined.
authors: W. Stefański Institute of Parasitology, Polish Academy of Sciences, Warsaw. wraniczm@twarda.pan.pl
authors: M J
authors: MJ
authors: Wranicz
authors: W
authors: W
authors: Cabaj
authors: B
authors: B
authors: Moskwa
mesh_terms: D000818:Animals; D005123:Eye / Q000469:parasitology*; D007814:Larva / Q000254:growth & development / Q000472:pathogenicity; D008297:Male; D051379:Mice; D018482:Muscle, Skeletal / Q000469:parasitology* / Q000473:pathology; D017160:Trichinella spiralis / Q000254:growth & development / Q000472:pathogenicity*; D014235:Trichinellosis / Q000469:parasitology* / Q000473:pathology