title: Cerebral lateralization of language in normal left-handed people studied by functional MRI.
abstract: OBJECTIVE
  To use functional MRI (fMRI) to further define the occurrence of left-hemisphere, bilateral, and right-hemisphere language in a normal left-handed population.
  
  
  METHODS
  A total of 100 healthy volunteers, consisting of 50 left-handed subjects and a reference group of 50 right-handed subjects, were studied by fMRI of the frontal cortex during silent word generation.
  
  
  RESULTS
  Ninety-six percent of right-handed subjects showed fMRI changes lateralized to the left hemisphere, whereas 4% showed a bilateral activation pattern. In contrast, left-hemisphere lateralization occurred in 76% of left-handers, bilateral activation in 14%, and right-hemisphere lateralization in the remaining 10%. The predominance of right-hemisphere activation, however, was weak in these cases; only a single left-handed subject (2%) showed complete right-hemisphere lateralization.
  
  
  CONCLUSIONS
  Silent word generation lateralizes to the left cerebral hemisphere in both handedness groups, but right-hemisphere participation is frequent in normal left-handed subjects. Exclusive right-hemisphere activation rarely occurred in the frontal lobe region studied.
authors: Magnetic Resonance Center of Pedralbes, Spain.
authors: J
authors: J
authors: Pujol
authors: J
authors: J
authors: Deus
authors: J M
authors: JM
authors: Losilla
authors: A
authors: A
authors: Capdevila
mesh_terms: D000328:Adult; D005260:Female; D005625:Frontal Lobe / Q000033:anatomy & histology* / Q000502:physiology; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007802:Language; D008279:Magnetic Resonance Imaging; D008297:Male; D013647:Task Performance and Analysis