title: [Autoantibodies to the thrombocytes and erythrocytes in HIV-infected patients].
abstract: In 48 patients with HIV infection were tested for the presence of autologous and allogenic antibodies to red blood cells with the use of Coombs' direct and indirect tests. 18 HIV-infected patients had IgG antibodies to thrombocytes, circulating in the blood (detected by the method of EIA) and bound to thrombocytes (detected by the method of RIA). In 5 out of 48 patients Coombs' direct test yielded positive results with red blood cells. 6 out of 18 examined patients had an elevated content of thrombocyte-bound antibodies. The presence of cross reactions between gp120 of human immunodeficiency virus and gp3a thrombocytes led to the formation of antithrombocyte antibodies and, consequently, to a decrease in the number of thrombocytes.
authors: Central Research Institute of Epidemiology, Hematological Research Center, Moscow, Russia.
authors: A V
authors: AV
authors: Kravchenko
authors: A M
authors: AM
authors: Poliakova
authors: S G
authors: SG
authors: Khasbekova
authors: S I
authors: SI
authors: Donskov
authors: O S
authors: OS
authors: Astrina
authors: V V
authors: VV
authors: Maleev
mesh_terms: D001323:Autoantibodies / Q000097:blood*; D001792:Blood Platelets / Q000276:immunology*; D004906:Erythrocyte Count; D004912:Erythrocytes / Q000276:immunology*; D015658:HIV Infections / Q000097:blood*; D015497:HIV-1; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D010976:Platelet Count
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G