title: Synthesis of a tetrasubstituted bicyclo [2.2.2] octane as a potential inhibitor of influenza virus sialidase.
abstract: A novel synthesis of the bicyclo [2.2.2] octane ring system has been achieved utilising a tandem Henry cyclisation as the key stage. This chemistry has been employed in the synthesis of a potential inhibitor of influenza virus sialidase.
authors: Department of Enzyme Medicinal Chemistry II, Glaxo Wellcome Medicines Research Centre, Stevenage, Herts UK. PS5776@GGR.CO.UK
authors: P W
authors: PW
authors: Smith
authors: N
authors: N
authors: Trivedi
authors: P D
authors: PD
authors: Howes
authors: S L
authors: SL
authors: Sollis
authors: G
authors: G
authors: Rahim
authors: R C
authors: RC
authors: Bethell
authors: S
authors: S
authors: Lynn
mesh_terms: D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009980:Influenza A virus / Q000201:enzymology*; D009981:Influenza B virus / Q000201:enzymology*; D009439:Neuraminidase / Q000037:antagonists & inhibitors*
chemical_list: C118935:4-acetylamino-3-hydroxy-5-n-propoxybicyclo(2.2.2)octane-1-carboxylic acid; D001643:Bridged Bicyclo Compounds; D002264:Carboxylic Acids; D004791:Enzyme Inhibitors; D009439:Neuraminidase