Ibogaine blocked methamphetamine-induced hyperthermia and induction of heat shock protein in mice.
Body temperature changes and heat shock protein (HSP-72) induction in the caudate nucleus were studied in female C57BL/6N mice pretreated with ibogaine (50 mg/kg) and sacrificed 48 h. after a single dose of methamphetamine (20 mg/kg). Methamphetamine injection resulted in hyperthermia and induced HSP-72 expression, whereas treatment with ibogaine alone produced hypothermia. The ibogaine followed by methamphetamine injection showed no hyperthermia and decreased HSP-72 expression. These data indicate that pretreatment with ibogaine can completely block methamphetamine-induced hyperthermia and HSP-72 expression in the striatum.
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Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079-9205, USA.
Imam
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Newport
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GD
Slikker
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W
Ali
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SF
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002421:Caudate Nucleus / Q000187:drug effects / Q000378:metabolism; D005260:Female; D005334:Fever / Q000139:chemically induced* / Q000517:prevention & control*; D050884:HSP72 Heat-Shock Proteins; D006360:Heat-Shock Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D007050:Ibogaine / Q000494:pharmacology*; D008694:Methamphetamine; D051379:Mice; D008810:Mice, Inbred C57BL
D050884:HSP72 Heat-Shock Proteins; D006360:Heat-Shock Proteins; D007050:Ibogaine; D008694:Methamphetamine