title: Intraosseous fibrous lesions of the jaws: a manifestation of tuberous sclerosis.
abstract: Four patients previously diagnosed with tuberous sclerosis are reported with intraosseous fibrous lesions of the jaws. Review of the literature revealed comparable pathosis occurring in extragnathic bones and several previous reports of similar lesions within the jaws. Therefore, these intraosseous fibrous proliferations are thought to represent an intraoral manifestation of tuberous sclerosis and not coincidental findings. In all 4 cases, the tumors demonstrated significant collagenization with numerous interspersed plump fibroblasts. Although histopathologically similar, the features of the lesions are not specific and also can be found in desmoplastic fibromas and simple odontogenic fibromas. The definitive diagnosis requires appropriate clinicopathologic correlation.
authors: University of Kentucky College of Dentistry, Lexington 40515-0297, USA.
authors: D D
authors: DD
authors: Damm
authors: C E
authors: CE
authors: Tomich
authors: D K
authors: DK
authors: White
authors: J F
authors: JF
authors: Drummond
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005355:Fibrosis / Q000209:etiology / Q000473:pathology; D006801:Humans; D007571:Jaw Diseases / Q000209:etiology* / Q000473:pathology; D008297:Male; D014402:Tuberous Sclerosis / Q000150:complications*