Identification of a novel HLA-C allele, Cw*0406, in a Singapore Malay.
A novel allele, C*0406, has been identified and is characterised by a single nucleotide substitution at position 196 of exon 3 when compared with its closest related allele, C*0403. The latter is found in 4/69 Chinese and 7/80 Malays while Cw*0406 was found in only one Malay individual within the study populations. The data suggest that Cw*0406 may have arisen as a relatively recent genetic event either by gene conversion or as a simple point mutation variant of Cw*0403.
Ren
E C
EC
Department of Microbiology and W.H.O. Collaborating Center for Immunology, National University of Singapore, Singapore.
Haniff
F
F
Loh
M T
MT
Chan
S H
SH
Petersdorf
E
E
Hansen
J
J
D000483:Alleles; D001483:Base Sequence; D018076:DNA, Complementary; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D012689:Sequence Homology, Nucleic Acid; D012846:Singapore
D018076:DNA, Complementary; D015236:HLA-C Antigens; C119147:HLA-C*04:06 antigen