Ca2+ and synaptic plasticity.
A major effort in neuroscience is directed towards understanding the roles of Ca2+ signalling in the induction of synaptic plasticity. Here, we summarize the evidence concerning Ca2+ signalling, paying particular attention to CA1 excitatory synapses, and its relationship to the induction of long-term potentiation and long-term depression. We discuss the ways in which synaptic activation can elevate Ca2+ postsynaptically and how dendritic spines may act as a Ca2+ compartment which can both isolate and integrate Ca2+ signals.
Chittajallu
R
R
Department of Anatomy, Medical School, University of Bristol, UK. r.chittajallu@bris.ac.uk
Alford
S
S
Collingridge
G L
GL
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D006624:Hippocampus / Q000502:physiology; D017774:Long-Term Potentiation; D009473:Neuronal Plasticity / Q000502:physiology*
D002118:Calcium