title: Influence of human immunodeficiency virus infection on chronic hepatitis B in homosexual men.
abstract: The aim of this study was to assess the influence of human immunodeficiency virus (HIV) infection on chronic hepatitis B. In a series of 132 (65 anti-HIV positive) homosexual non-drug addicted men with chronic hepatitis B, the liver function was assessed with biochemical tests; the degree of hepatitis B virus (HBV) replication was assessed with serum HBV DNA level and with immunoperoxidase staining of hepatitis B core (HBc) antigen on liver specimens; and the severity of liver lesions was assessed with an histology activity index. Anti-HIV-positive and anti-HIV-negative patients were not different for serum aspartate transaminase activity, bilirubin, prothrombin, and histology activity index. Anti-HIV-positive patients had lower serum alanine transaminase activity levels (P =.0001), lower serum albumin levels (P =.0009), and higher serum HBV DNA levels (P =.01). There was a higher prevalence of cirrhosis in anti-HIV-positive patients (P =.04). In homosexual men with chronic hepatitis B, HIV infection is associated with a higher level of HBV replication and a higher risk for cirrhosis without increased liver necrotico-inflammatory process.
authors: Service d'Hépatologie, Centre de Recherche Claude Bernard sur les Hépatites Virales and INSERM U481, Clichy, France.
authors: J F
authors: JF
authors: Colin
authors: D
authors: D
authors: Cazals-Hatem
authors: M A
authors: MA
authors: Loriot
authors: M
authors: M
authors: Martinot-Peignoux
authors: B N
authors: BN
authors: Pham
authors: A
authors: A
authors: Auperin
authors: C
authors: C
authors: Degott
authors: J P
authors: JP
authors: Benhamou
authors: S
authors: S
authors: Erlinger
authors: D
authors: D
authors: Valla
authors: P
authors: P
authors: Marcellin
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D001706:Biopsy; D004279:DNA, Viral / Q000097:blood; D015658:HIV Infections / Q000097:blood / Q000150:complications*; D006513:Hepatitis B e Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000254:growth & development / Q000378:metabolism; D019694:Hepatitis B, Chronic / Q000097:blood / Q000150:complications* / Q000378:metabolism; D018451:Homosexuality, Male; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000378:metabolism / Q000821:virology; D008111:Liver Function Tests; D008297:Male; D012307:Risk Factors; D012709:Serum Albumin / Q000378:metabolism
chemical_list: D004279:DNA, Viral; D006513:Hepatitis B e Antigens; D012709:Serum Albumin; D000410:Alanine Transaminase