title: Synthesis of tetrasubstituted bicyclo[3.2.1]octenes as potential inhibitors of influenza virus sialidase.
abstract: Several racemic bicyclo[3.2.1]octene derivatives have been synthesised and evaluated as inhibitors of influenza virus sialidases. The 5-acetamido-bicyclo[3.2.1]octenol 4 showed modest activity against influenza A and B virus sialidases.
authors: Department of Enzyme Medicinal Chemistry II, Glaxo Wellcome Medicines Research Centre, Stevenage, Herts UK. PSJ3049@GlaxoWellcome.co.uk
authors: P S
authors: PS
authors: Jones
authors: P W
authors: PW
authors: Smith
authors: G W
authors: GW
authors: Hardy
authors: P D
authors: PD
authors: Howes
authors: R J
authors: RJ
authors: Upton
authors: R C
authors: RC
authors: Bethell
mesh_terms: D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D009980:Influenza A virus / Q000201:enzymology*; D009981:Influenza B virus / Q000201:enzymology*; D009439:Neuraminidase / Q000037:antagonists & inhibitors*
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D004791:Enzyme Inhibitors; D009439:Neuraminidase