title: Synthesis and hybridization property of an oligonucleotide containing a 3-thioformacetal linked pentathymidylate.
abstract: A pentathymidylate fully substituted with 3'-thioformacetal intemucleotidic linkages was synthesized and subsequently incorporated into an oligonucleotide (ON) 15mer. Tm analysis was performed on the resulting ON hybridized with its complementary RNA. This duplex demonstrated slightly improved binding affinity relative to the control phosphate diester ON/RNA hybrid.
authors: Gilead Sciences, Inc., Foster City CA 94404, USA.
authors: J
authors: J
authors: Zhang
authors: J T
authors: JT
authors: Shaw
authors: M D
authors: MD
authors: Matteucci
mesh_terms: D000080:Acetals / Q000737:chemistry*; D001483:Base Sequence; D009693:Nucleic Acid Hybridization; D012313:RNA / Q000378:metabolism; D013440:Sulfides / Q000737:chemistry*; D013942:Thymine Nucleotides / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism
chemical_list: D000080:Acetals; D013440:Sulfides; D013942:Thymine Nucleotides; D012313:RNA