title: RTS, a computer program for the experimental set-up and interpretation of ruggedness tests.
abstract: A computer program is described for the experimental set-up and interpretation of ruggedness tests. The implemented strategy was based on a number of case studies and contains both recommended designs and minimal designs. The minimal designs reduce the number of experiments, but they cannot be statistically interpreted based on the interaction or dummy factor effects. The use of randomization tests as an alternative statistical interpretation method for the significance of the effects was examined. Some of the minimal designs are expandable to designs with characteristics similar to those of the recommended designs. The program is designed to facilitate the selection of the designs and the interpretation of the results and to prevent or detect problems such as drifting of responses.
authors: ChemoAC, Pharmaceutical Institute, Vrije Unversiteit Brussel, Brussels, Belgium.
authors: F
authors: F
authors: Questier
authors: Y
authors: Y
authors: Vander Heyden
authors: D L
authors: DL
authors: Massart
mesh_terms: D002623:Chemistry Techniques, Analytical / Q000379:methods*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D011897:Random Allocation; D015203:Reproducibility of Results; D012107:Research Design; D012984:Software; D013752:Tetracycline / Q000032:analysis*
chemical_list: D013752:Tetracycline