title: Isolation and identification of dihydroartemisinic acid from artemisia annua and its possible role in the biosynthesis of artemisinin
abstract: Dihydroartemisinic acid (2) was isolated as a natural product from Artemisia annua in a 66% yield, and its structure was confirmed by 1H and 13C NMR spectroscopy. Compound 2 could be chemically converted to artemisinin (4) under conditions that may also be present in the living plant. The results suggest that the conversion of 2 into 4 in the living plant might be a nonenzymatic conversion.
authors: Department of Pharmaceutical Biology, University Centre for Pharmacy, Groningen Institute for Drug Studies, University of Groningen, A. Deusinglaan 1, NL-9713 AV Groningen, The Netherlands.
authors: TE
authors: Wallaart
authors: van Uden W
authors: HG
authors: Lubberink
authors: HJ
authors: Woerdenbag
authors: N
authors: Pras
authors: WJ
authors: Quax