The association between laser Doppler reactive hyperaemia curves and the distribution of peripheral arterial disease.
OBJECTIVE
To determine whether postocclusive laser Doppler fluxmetry (LDF) curves can be related to the arteriographic distribution of disease.


METHODS
Prospective study.


METHODS
Sixty-nine patients with symptomatic peripheral ischaemia and 15 healthy subjects.


METHODS
Laser Doppler fluxmetry (LDF) was monitored on the dorsum of the symptomatic foot following 2 min of arterial occlusion at the ankle. During reperfusion three patterns of LDF were identified (types I-III). All patients subsequently underwent arteriography which was reported independent of LDF results. The distribution of disease, particularly patency of below-knee vessels, was related to the type of LDF curve observed during reactive hyperaemia.


RESULTS
Type I curves were observed in all healthy subjects and 75% of patients with a single arterial lesion. Type II curves were found in 78% of patients with multiple lesions above the knee. The presence of either a type I or II curve was associated with a continuous vessel from knee to ankle (positive predictive value 83%, p < 0.01), whilst type III curve was associated with discontinuous infrapopliteal run-off (positive predictive value 86%, p < 0.01).


CONCLUSIONS
This pilot study suggests that post-occlusive LDF curves may identify the distribution of arterial disease and may be useful in the non-invasive management of peripheral ischaemia.
Ray
S A
SA
Department of Vascular Surgery and Interventional Radiology, St. George's Hospital Medical School, Tooting, London, U.K.
Buckenham
T M
TM
Belli
A M
AM
Taylor
R S
RS
Dormandy
J A
JA
D016009:Chi-Square Distribution; D006801:Humans; D006940:Hyperemia / Q000175:diagnosis*; D007511:Ischemia / Q000175:diagnosis; D017078:Laser-Doppler Flowmetry / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D007866:Leg / Q000098:blood supply*; D016491:Peripheral Vascular Diseases / Q000175:diagnosis*; D010865:Pilot Projects; D011446:Prospective Studies; D013997:Time Factors