title: Synthetic [5,5] trans-fused indane lactones as inhibitors of thrombin.
abstract: Synthesis of trans-fused lactones containing the indane nucleus has resulted in a series of potent acylating inhibitors of thrombin. As an example compound 11e has an apparent second order rate constant of 11 x 10(6) M(-1)sec(-1) for the inhibition of thrombin. The anticoagulant activity of these compounds is discussed.
authors: Glaxo Wellcome Research and Development, Stevenage, Herts, United Kingdom. mp8073@glaxowellcome.co.uk
authors: M
authors: M
authors: Pass
authors: R E
authors: RE
authors: Bolton
authors: S J
authors: SJ
authors: Coote
authors: H
authors: H
authors: Finch
authors: S
authors: S
authors: Hindley
authors: A
authors: A
authors: Lowdon
authors: E
authors: E
authors: McDonald
authors: J
authors: J
authors: McLaren
authors: M
authors: M
authors: Owen
authors: N A
authors: NA
authors: Pegg
authors: C J
authors: CJ
authors: Mooney
authors: C M
authors: CM
authors: Tang
authors: S
authors: S
authors: Parry
authors: C
authors: C
authors: Patel
mesh_terms: D000925:Anticoagulants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000991:Antithrombins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D007189:Indans / Q000737:chemistry*; D007700:Kinetics; D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010314:Partial Thromboplastin Time
chemical_list: D000925:Anticoagulants; D000991:Antithrombins; D007189:Indans; D007783:Lactones