title: Tamm-Horsfall protein excretion and its relation to citrate in urine of stone-forming patients.
abstract: OBJECTIVE
  To evaluate the relation of Tamm-Horsfall protein (THP) and citrate, both potent actors in the urinary stone forming process.
  
  
  METHODS
  Quantitative determination of THP in calcium oxalate (CaOx) stone-forming patients and healthy subjects was carried out according to the enzyme-linked immunosorbent assay method.
  
  
  RESULTS
  THP excretion in 24-hour urine samples of CaOx stone-forming patients was significantly reduced compared with healthy subjects. A significant correlation exists between the concentration of THP and citrate in the stone-forming group, as well as in the group of healthy subjects, and for the 24-hour excretion, this correlation persists in the group of CaOx stone-forming patients.
  
  
  CONCLUSIONS
  Decreased THP and citrate excretions were found in CaOx stone-forming patients. They indicate a tubular dysfunction of the distal section.
authors: Department of Urology, University of Bonn, Germany.
authors: K
authors: K
authors: Ganter
authors: D
authors: D
authors: Bongartz
authors: A
authors: A
authors: Hesse
mesh_terms: D000328:Adult; D019343:Citric Acid / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009088:Mucoproteins / Q000652:urine*; D014545:Urinary Calculi / Q000652:urine*; D058949:Uromodulin
chemical_list: D009088:Mucoproteins; C548612:UMOD protein, human; D058949:Uromodulin; D019343:Citric Acid