Effect of glucose on the plasma concentration and urinary excretion of uridine and purine bases.
To examine whether glucose increases the plasma concentration of purine bases and uridine, 75 g glucose was administered orally to eight healthy subjects and two patients with hyperuricemia. The plasma concentration of uridine increased by 21%, 25%, and 20% 30, 60, and 90 minutes after administration of glucose, respectively. However, urinary excretion of uridine was not affected, nor were the plasma concentrations and urinary excretion of purine bases (hypoxanthine, xanthine, and uric acid). These results suggest that the glucose-induced increase in plasma uridine was not concomitant with adenosine triphosphate (ATP) consumption-induced purine degradation, but instead was ascribable to a uridine diphosphate (UDP)-glucose consumption-induced pyrimidine degradation (UDP-glucose-->UDP-->uridine monophosphate [UMP]-->uridine).
Yamamoto
T
T
Third Department of Internal Medicine, Hyogo College of Medicine, Japan.
Moriwaki
Y
Y
Takahashi
S
S
Tsutsumi
Z
Z
Yamakita
J
J
Nakano
T
T
Higashino
K
K
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D005934:Glucagon / Q000097:blood; D005947:Glucose / Q000494:pharmacology*; D006801:Humans; D007328:Insulin / Q000097:blood; D019344:Lactic Acid / Q000097:blood; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000097:blood; D011687:Purines / Q000097:blood* / Q000652:urine*; D019289:Pyruvic Acid / Q000097:blood; D014529:Uridine / Q000097:blood* / Q000652:urine*
D001786:Blood Glucose; D007328:Insulin; D010710:Phosphates; D011687:Purines; D019344:Lactic Acid; D019289:Pyruvic Acid; D005934:Glucagon; D005947:Glucose; D014529:Uridine