Four new DP alleles identified in a study of 500 unrelated bone marrow donor-recipient pairs.
HLA-DP genotyping of 500 donor recipient pairs in a retrospective analysis sponsored by the National Marrow Donor Program (NMDP) identified four new DP alleles, two DPB1 and two DPA1. DNA sequencing confirmed that DPB1*8001 and *8101, each found in a single individual, are novel combinations of previously described sequence motifs in the six variable regions of DPB1. DPA1*02014, found in two individuals, is identical to DPA1*02011 except for a novel silent substitution, a G to A transition at the third position of codon 14. DPA1*01032, found in one individual, is identical to DPB1*01031 except for a silent G to A transition at the third position of codon 20. The identification of these novel alleles brings the total number of reported DPB1 alleles to 85 and DPA1 alleles to 15.
Steiner
L L
LL
Department of Human Genetics, Roche Molecular Systems, Alameda, California 94501, USA.
Wu
J
J
Noreen
H J
HJ
Moehlenkamp
C
C
Cavalli
A
A
Davidson
M
M
Johnson
S
S
Winden
T
T
Segall
M
M
Begovich
A B
AB
Williams
T M
TM
D000483:Alleles; D000595:Amino Acid Sequence; D001483:Base Sequence; D001782:Blood Donors; D001853:Bone Marrow; D018076:DNA, Complementary; D005838:Genotype; D006682:HLA-DP Antigens / Q000145:classification / Q000235:genetics*; D059867:HLA-DP alpha-Chains; D059868:HLA-DP beta-Chains; D006801:Humans; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid
D018076:DNA, Complementary; D006682:HLA-DP Antigens; D059867:HLA-DP alpha-Chains; D059868:HLA-DP beta-Chains; C071172:HLA-DPA1 antigen; C071170:HLA-DPB1 antigen