Does the 'mystery of the extra glucose' during CNS activation reflect glutamate synthesis?
The hypothesis is proposed that the repeatedly demonstrated rise in local cerebral blood flow and glucose utilisation during neuronal activation, without a corresponding increase in oxygen utilisation, may reflect glutamine formation from glucose, followed by complete oxidative degradation of glutamate along complex and extended, but well described pathways, known to operate in the brain. The former process requires large amounts of glucose but little oxygen. The latter utilises oxygen but no additional glucose, is a prolonged process and so at any one time involves only a small increase in the rate of oxygen utilisation which is difficult to demonstrate experimentally.
Hertz
L
L
Department of Pharmacology, University of Saskatchewan, Saskatoon, Canada.
Fillenz
M
M
D001921:Brain / Q000098:blood supply / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D018698:Glutamic Acid / Q000096:biosynthesis*; D006801:Humans; D007700:Kinetics; D009474:Neurons / Q000378:metabolism; D010084:Oxidation-Reduction; D010101:Oxygen Consumption
D018698:Glutamic Acid; D005947:Glucose