Complexity in biological signaling systems.
Biological signaling pathways interact with one another to form complex networks. Complexity arises from the large number of components, many with isoforms that have partially overlapping functions; from the connections among components; and from the spatial relationship between components. The origins of the complex behavior of signaling networks and analytical approaches to deal with the emergent complexity are discussed here.
Weng
G
G
Department of Pharmacology, Mount Sinai School of Medicine, New York, NY 10029, USA.
Bhalla
U S
US
Iyengar
R
R
D000818:Animals; D002451:Cell Compartmentation; D002462:Cell Membrane / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D003198:Computer Simulation; D003599:Cytoskeleton / Q000502:physiology; D016208:Databases, Factual; D019204:GTP-Binding Proteins / Q000378:metabolism; D005796:Genes; D006801:Humans; D008954:Models, Biological; D016571:Neural Networks, Computer; D009474:Neurons / Q000378:metabolism; D015398:Signal Transduction
D019204:GTP-Binding Proteins