Arterial calcification as a marker for atherosclerosis in three Arctic populations.
Accumulation of calcification in the arterial wall in the course of the atherogenic process is considered to be a manifestation of advanced atherosclerosis. In this study of autopsy specimens from Alaska non-Natives, Alaska Natives, and Greenland Natives, comparisons were made of the prevalence and extent of arterial calcification with that of all raised (advanced) lesions in the thoracic aorta, abdominal aorta, right coronary artery, and left anterior descending coronary artery, to determine the degree to which calcified lesions track the development of advanced lesions. Calcification was determined quantitatively from radiograph images of the fixed specimens; advanced lesion data on these specimens were available from prior studies. Findings show that the prevalence and extent of calcified lesions closely follows the pattern of prevalence and extent of advanced lesions among the groups. We conclude that calcification is a good marker for comparisons of the prevalence and may also provide a good measure of the extent of atherosclerosis in these populations.
Troxclair
D
D
Department of Pathology, Louisiana State University Medical Center, New Orleans, USA.
Boudreau
D A
DA
Malcom
G T
GT
Pedersen
H S
HS
Mulvad
G
G
Newmann
W P
WP
Middaugh
J P
JP
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000413:Alaska / Q000453:epidemiology; D000792:Angiography; D001110:Arctic Regions / Q000453:epidemiology; D001158:Arteries / Q000473:pathology*; D001161:Arteriosclerosis / Q000453:epidemiology / Q000473:pathology*; D001344:Autopsy; D015415:Biomarkers / Q000032:analysis; D002114:Calcinosis / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology*; D002648:Child; D046508:Culture Techniques; D005006:Ethnicity / Q000706:statistics & numerical data; D005260:Female; D006116:Greenland / Q000453:epidemiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D017678:Sex Distribution
D015415:Biomarkers