Salinomycin-induced polyneuropathy in cats: morphologic and epidemiologic data.
In April 1996, an outbreak of toxic polyneuropathy in cats occurred in the Netherlands. All cats had been fed one of two brands of dry cat food from one manufacturer. Chemical analyses of these foods, stomach contents, and liver and kidney of affected cats revealed contamination with the ionophor salinomycin. Epidemiologic and clinical data were collected from 823 cats, or about 1% of the cats at risk. In 21 affected cats, postmortem examination was performed. The affected cats had acute onset of lameness and paralysis of the hindlimbs followed by the forelimbs. Clinical and pathologic examination indicated a distal polyneuropathy involving both the sensory and motor nerves.
van der Linde-Sipman
J S
JS
Department of Pathology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands. thi@dgk.ruu.nl
van den Ingh
T S
TS
van nes
J J
JJ
Verhagen
H
H
Kersten
J G
JG
Beynen
A C
AC
Plekkringa
R
R
D000821:Animal Feed / Q000633:toxicity*; D000818:Animals; D002371:Cat Diseases / Q000139:chemically induced* / Q000453:epidemiology / Q000473:pathology; D002415:Cats; D003049:Coccidiostats / Q000506:poisoning*; D004196:Disease Outbreaks / Q000662:veterinary*; D005260:Female; D005506:Food Contamination; D005552:Forelimb; D006614:Hindlimb; D007476:Ionophores / Q000506:poisoning; D007794:Lameness, Animal / Q000209:etiology; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D010525:Peripheral Nerves / Q000473:pathology; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D011714:Pyrans / Q000506:poisoning*; D000095662:Polyether Polyketides
D003049:Coccidiostats; D007476:Ionophores; D011714:Pyrans; C010327:salinomycin; D000095662:Polyether Polyketides