Mapping of the MYCL2 processed gene to Xq22-23 and identification of an additional L MYC-related sequence in Xq27.2.
We report here the identification of a human genomic sequence from the q27.2 region of the X chromosome which shows a high homology to the L-MYC proto-oncogene. This sequence is not the MYCL2 homology, previously mapped to the long arm of the X chromosome at q22-qter by Morton et al., as we located the MYCL2-processed gene in Xq22-23, using a panel containing a combination of hybrid DNA carrying different portions of the human X chromosome. Based on computer analysis, the MYC-like sequence (MYCL3) is 98.2% identical to a portion of exon 3 of the MYCL1 gene and maps to the Xq27.2 region, between the DXS312 and DXS292 loci.
Redolfi
E
E
Istituto di Tecnologie Biomediche Avanzate, CNR, Segrate, Italy.
Pizzuti
A
A
Di Bacco
A
A
Susani
L
L
Labella
T
T
Affer
M
M
Montagna
C
C
Reinbold
R
R
Mumm
S
S
Vezzoni
P
P
Zucchi
I
I
D002874:Chromosome Mapping; D018076:DNA, Complementary; D006801:Humans; D009693:Nucleic Acid Hybridization; D000090063:Proto-Oncogene Mas; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics*; D017422:Sequence Analysis, DNA; D014960:X Chromosome
D018076:DNA, Complementary; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D016271:Proto-Oncogene Proteins c-myc