title: Ambulatory blood pressure nondipping status in salt-sensitive and salt-resistant black adolescents.
abstract: This study examined the relationship between salt sensitivity and ambulatory blood pressure in 53 healthy black adolescents. Salt sensitivity was defined as an increase in mean blood pressure greater than or exceeding 5 mm Hg from a 5-day low-salt diet (50 mmol/24 h) to a 10-day high-salt diet (150 mmol/24 h NaCl supplement). Sixteen subjects were salt sensitive and 37 subjects were salt resistant (showed < 5 mm Hg increase in mean blood pressure). Subjects were classified as dippers (> or =10% decrease in blood pressure from awake to asleep) based on their 24-h ambulatory blood pressure values. Nondippers showed higher systolic, diastolic, and mean asleep blood pressures than dippers (P < .05 for all). Salt-sensitive subjects showed greater daytime diastolic and mean blood pressures than salt-resistant subjects (P < .05 for both). A significantly greater percentage of nondippers were salt sensitive, compared with salt resistant for diastolic blood pressure (P < .001) and mean blood pressure (P < .05). For both of these blood pressure measures, 50% of the salt-sensitive subjects had a nondipping status, compared with only 5.4% of the salt-resistant subjects for diastolic blood pressure, and 18.9% of the salt-resistant subjects for mean blood pressure. These results are the first to indicate that salt sensitivity is associated with nondipper blood pressure status in a black normotensive adolescent population.
authors: Department of Medicine, Medical College of Virginia/Virginia Commonwealth University, Richmond 23298-0160, USA.
authors: D K
authors: DK
authors: Wilson
authors: D A
authors: DA
authors: Sica
authors: S B
authors: SB
authors: Miller
mesh_terms: D000293:Adolescent; D044383:Black People; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory; D002940:Circadian Rhythm / Q000502:physiology*; D004198:Disease Susceptibility / Q000209:etiology / Q000503:physiopathology / Q000652:urine; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology / Q000652:urine; D008297:Male; D012016:Reference Values; D012307:Risk Factors; D012964:Sodium / Q000652:urine; D012982:Sodium, Dietary / Q000494:pharmacology*
chemical_list: D012982:Sodium, Dietary; D012964:Sodium