Detection of thromboxane A2 receptor mRNA in the nasal mucosa of patients with allergic rhinitis.
Previous reports suggest that thromboxane (TX) A2 plays an important role in bronchial asthma, especially in the development of airway hypersensitivity. Similarly to asthmatic subjects, the nasal mucosa in patients with allergic rhinitis is hypersensitive to non-specific stimuli. Allergic rhinitis is mediated by chemical mediators released from inflammatory cells. However, the involvement of TXA2 in allergic rhinitis has been studied very little. Recently, TXA2 receptors from humans and mice have been characterized at the molecular level. We performed RT-PCR to examine whether TXA2 receptor mRNA expression is elevated higher in allergic rhinitis than in chronic sinusitis. We found that TXA2 receptor mRNA was expressed both in the nasal inferior turbinates with allergic rhinitis and in the maxillary sinus mucosa with chronic inflammation at a similar level. This result suggests that TXA2 receptor mRNA expression is not enhanced in allergic rhinitis.
Maesako
K
K
Preclinical Research Department, Bayer Yakuhin, Ltd., Osaka, Japan.
Takeuchi
K
K
Yuta
A
A
Ukai
K
K
Sakakura
Y
Y
D000293:Adolescent; D000328:Adult; D000818:Animals; D015139:Blotting, Southern; D002908:Chronic Disease; D004391:Dust; D005260:Female; D006801:Humans; D008297:Male; D015523:Maxillary Sinusitis / Q000276:immunology; D008875:Middle Aged; D008925:Mites / Q000276:immunology; D009297:Nasal Mucosa / Q000737:chemistry / Q000276:immunology*; D012333:RNA, Messenger / Q000032:analysis; D017482:Receptors, Thromboxane / Q000032:analysis*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology*
D004391:Dust; D012333:RNA, Messenger; D017482:Receptors, Thromboxane