title: HIV-1 (p24)-positive multinucleated giant cells in HIV-associated lymphoepithelial lesion of the parotid gland. A report of two cases.
abstract: BACKGROUND
  Cystic benign lymphoepithelial lesion (CBLL) is a well-recognized parotid disorder the diagnosis of which can be made on the basis of clinical findings, human immunodeficiency virus (HIV) testing, image studies and fine needle aspiration (FNA). Most aspirations are cystic, and the lesion can be recognized if the triad of foamy macrophages, lymphoid and epithelial (squamous) cells is observed.
  
  
  METHODS
  The authors recently observed FNA cytologic features of two HIV-associated cases that exhibited numerous multinucleated giant cells (MGCs) but failed to show the epithelial component. A subsequent surgical resection was performed in one patient. Similarly to what has been described for nasopharyngeal (adenoid and tonsil) lymphoid tissue of HIV-positive patients, intense immunoexpression of S-100 and p24 (HIV-1) protein was present in MGC.
  
  
  CONCLUSIONS
  The diagnosis of HIV-associated CBLL should always be considered if a parotid cystic lesion presents with numerous MGCs. Immunocytochemical detection of p24 (HIV-1) protein in MGC becomes a very useful diagnostic aid and extends to parotid CBLL many of those pathogenic features of HIV-1 infection already noted in other HIV-1-infected, lymphoid oropharyngeal lesions.
authors: Department of Pathology, La Paz University Hospital, Madrid, Spain.
authors: B
authors: B
authors: Vicandi
authors: J A
authors: JA
authors: Jiménez-Heffernan
authors: P
authors: P
authors: López-Ferrer
authors: M
authors: M
authors: Patrón
authors: C
authors: C
authors: Gamallo
authors: C
authors: C
authors: Colmenero
authors: J M
authors: JM
authors: Viguer
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D002467:Cell Nucleus / Q000473:pathology / Q000821:virology; D003560:Cysts / Q000473:pathology / Q000821:virology*; D015726:Giant Cells / Q000473:pathology / Q000821:virology*; D016655:HIV Core Protein p24 / Q000032:analysis*; D015658:HIV Infections / Q000473:pathology*; D015497:HIV-1; D006801:Humans; D008297:Male; D008875:Middle Aged; D010305:Parotid Diseases / Q000473:pathology / Q000821:virology*
chemical_list: D016655:HIV Core Protein p24