[Prophylaxis of recurrence in superficial bladder carcinoma by intravesical chemotherapy--comparative study between instillation of combined double anticancer agents and single anticancer agent].
We performed a study to compare the usefulness of double or single anticancer agents in the prophylactic treatment after the transurethral resection (TUR) of superficial bladder cancer. We experienced 127 superficial bladder cancer cases. Of these cases, 42 were treated with intravesical adriamycin (ADR) and peplomycin (PEP), 56 with ADR, PEP, epirubicin (epi-ADR) or pirarubicin (THP) only, and the remaining 29 with TUR only. Nonrecurrence rates were significantly higher in the intravesical treated cases than in the cases with TUR only, and also significantly higher in the cases treated with ADR and PEP than the other treated cases. We concluded that intravesical chemotherapy with combined agents was more effective than with a single agent.
Ikeda
R
R
Dept. of Urology, Kanazawa Medical University.
Chikazawa
I
I
Kobayashi
Y
Y
Shiroma
K
K
Nakade
T
T
Suga
K
K
Shiba
N
N
Nakajima
C
C
Moriyama
M
M
Kawamura
K
K
Miyazawa
K
K
Tanaka
T
T
Tsugawa
R
R
Suzuki
K
K
Sato
H
H
Kikuyama
A
A
D000283:Administration, Intravesical; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D004317:Doxorubicin / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D017663:Peplomycin / Q000008:administration & dosage*; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy*
D000903:Antibiotics, Antineoplastic; D017663:Peplomycin; D004317:Doxorubicin