title: S phase and differential DNA replication during Drosophila oogenesis.
abstract: A modified cell cycle, the endo cycle, produces the polyploid or polytene cells that are present in some tissues of most organisms. In the endo cycle, the S phase alternates with a gap phase, but mitosis does not occur. Genes needed to inhibit mitosis during the endo cycle and to promote the onset of S phase have been identified in Drosophila. Genomic intervals are differentially replicated during the endo cycle S phase such that some regions are under-replicated, while others can be amplified. Cyclin E and E2F are needed for this differential DNA replication during Drosophila oogenesis.
authors: Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
authors: I
authors: I
authors: Royzman
authors: T L
authors: TL
authors: Orr-Weaver
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000235:genetics; D002843:Chromatin / Q000235:genetics; D019926:Cyclin B / Q000235:genetics / Q000378:metabolism; D004261:DNA Replication; D004330:Drosophila / Q000502:physiology*; D029721:Drosophila Proteins; D005260:Female; D007247:Infertility, Female / Q000235:genetics; D008938:Mitosis; D009866:Oogenesis / Q000502:physiology*; D010053:Ovary / Q000502:physiology; D011123:Polyploidy; D016196:S Phase / Q000235:genetics*
chemical_list: D002843:Chromatin; C503698:CycB protein, Drosophila; D019926:Cyclin B; D029721:Drosophila Proteins