The role of oxidized low-density lipoprotein in the activation of peroxisome proliferator-activated receptor gamma: implications for atherosclerosis.
A molecular mechanism has been discovered that helps explain the formation of foam cells, which are components of atherosclerotic plaque. It involves the stimulation by oxidized low-density lipoprotein of its own uptake into macrophages through activation of the peroxisome proliferator-activated receptor gamma.
Wolf
G
G
Department of Nutritional Sciences, University of California, Berkeley 94720-3104, USA.
D001161:Arteriosclerosis / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism / Q000494:pharmacology*; D008264:Macrophages / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000378:metabolism*; D020218:Response Elements; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
D008077:Lipoproteins, LDL; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; C099252:oxidized low density lipoprotein