Protection by short-chain fatty acids against 1-beta-D-arabinofuranosylcytosine-induced intestinal lesions in germfree mice.
In germfree mice, the administration of short-chain fatty acids (SCFA) protected the intestinal mucosa from damage produced by 1-beta-D-arabinofuranosylcytosine (Ara-C). Animals receiving SCFA and Ara-C had intestinal morphologies closer to normal than the control animals, which had severe intestinal lesions. We concluded that orally administrated SCFA reduce intestinal lesions, improving the mucosa pattern of the small intestine and colon.
Ramos
M G
MG
Departamento de Bioquímica e Imunologia, ICB-UFMG, Belo Horizonte, MG, Brazil.
Bambirra
E A
EA
Nicoli
J R
JR
Cara
D C
DC
Vieira
E C
EC
Alvarez-Leite
J
J
D000284:Administration, Oral; D000818:Animals; D003561:Cytarabine / Q000009:adverse effects*; D004195:Disease Models, Animal; D005232:Fatty Acids, Volatile / Q000009:adverse effects / Q000627:therapeutic use*; D005234:Fatty Liver / Q000139:chemically induced; D007410:Intestinal Diseases / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology; D051379:Mice; D020011:Protective Agents / Q000009:adverse effects / Q000627:therapeutic use*
D005232:Fatty Acids, Volatile; D020011:Protective Agents; D003561:Cytarabine