IC202A, a new siderophore with immunosuppressive activity produced by Streptoalloteichus sp. 1454-19. I. Taxonomy, fermentation, isolation and biological activity.
IC202A, a new immunosuppressive compound, was isolated from the culture filtrate of Streptoalloteichus sp. 1454-19. It showed a suppressive effect on mixed lymphocyte culture reaction with an IC50 value of 3.6 microg/ml and mitogen induced lymphocyte blastogenesis in vitro.
Iijima
M
M
Institute for Chemotherapy, MCRF, Shizuoka, Japan.
Someno
T
T
Imada
C
C
Okami
Y
Y
Ishizuka
M
M
Takeuchi
T
T
D000192:Actinomycetales / Q000145:classification / Q000378:metabolism*; D000577:Amides / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002712:Chlorides; D003676:Deferoxamine / Q000494:pharmacology; D005285:Fermentation; D005290:Ferric Compounds / Q000494:pharmacology; D006877:Hydroxamic Acids / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000302:isolation & purification / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008809:Mice, Inbred C3H; D008934:Mitogens / Q000494:pharmacology; D017262:Siderophores / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology*
D000577:Amides; D002712:Chlorides; D005290:Ferric Compounds; D006877:Hydroxamic Acids; C118260:IC 202A; D007166:Immunosuppressive Agents; D008934:Mitogens; D017262:Siderophores; D003676:Deferoxamine; C024555:ferric chloride