[The importance of angiogenesis in tumor growth dynamics].
The interactions between tumor cells and cellular compartments of direct environment, including soluble ECM factors, in the mechanisms of cancer progressive growth are discussed. Experimental data showing the role of increased apoptotic index even with unchanged proliferation rate in achieving the tumor "dormant state" are presented. The role of various molecules and factors involved in the process of tumor angiogenesis and their value as diagnostic and prognostic markers in cancer patients is discussed. The new antitumor therapeutical strategies based on an antiangiogenic activity of new potential agents are reviewed.
Radzikowski
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Zakład Immunologii Nowotworów, Instytutu Immunologii i Terapii Doświadczalnej im. L. Hirszfelda PAN, Wrocławiu.
Opolski
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Wietrzyk
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D000818:Animals; D017209:Apoptosis / Q000502:physiology; D014408:Biomarkers, Tumor / Q000032:analysis; D015815:Cell Adhesion Molecules / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D010447:Peptide Hydrolases / Q000032:analysis
D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules; D016207:Cytokines; D010447:Peptide Hydrolases