title: Growth in the presence of salicylate increases fluoroquinolone resistance in Staphylococcus aureus.
abstract: Salicylate and acetylsalicylate slightly increased fluoroquinolone resistance in ciprofloxacin-susceptible and -resistant Staphylococcus aureus. Salicylate allowed a greater number of cells from ciprofloxacin-susceptible and -resistant strains to survive on high fluoroquinolone concentrations. Salicylate also increased the frequency with which a susceptible strain mutated to become more resistant to ciprofloxacin.
authors: Microbiology Group, School of Biomedical Sciences, Curtin University of Technology, Western Australia, Australia. tgustafs@alpha2.curtin.edu.au
authors: J E
authors: JE
authors: Gustafson
authors: P V
authors: PV
authors: Candelaria
authors: S A
authors: SA
authors: Fisher
authors: J P
authors: JP
authors: Goodridge
authors: T M
authors: TM
authors: Lichocik
authors: T M
authors: TM
authors: McWilliams
authors: C T
authors: CT
authors: Price
authors: F G
authors: FG
authors: O'Brien
authors: W B
authors: WB
authors: Grubb
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D004347:Drug Interactions; D004352:Drug Resistance, Microbial / Q000235:genetics / Q000502:physiology; D024841:Fluoroquinolones; D008826:Microbial Sensitivity Tests; D012459:Salicylates / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics
chemical_list: D000890:Anti-Infective Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D024841:Fluoroquinolones; D012459:Salicylates