title: Identification of a novel HLA-C allele, Cw*0406, in a Singapore Malay.
abstract: A novel allele, C*0406, has been identified and is characterised by a single nucleotide substitution at position 196 of exon 3 when compared with its closest related allele, C*0403. The latter is found in 4/69 Chinese and 7/80 Malays while Cw*0406 was found in only one Malay individual within the study populations. The data suggest that Cw*0406 may have arisen as a relatively recent genetic event either by gene conversion or as a simple point mutation variant of Cw*0403.
authors: Department of Microbiology and W.H.O. Collaborating Center for Immunology, National University of Singapore, Singapore.
authors: E C
authors: EC
authors: Ren
authors: F
authors: F
authors: Haniff
authors: M T
authors: MT
authors: Loh
authors: S H
authors: SH
authors: Chan
authors: E
authors: E
authors: Petersdorf
authors: J
authors: J
authors: Hansen
mesh_terms: D000483:Alleles; D001483:Base Sequence; D018076:DNA, Complementary; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D012689:Sequence Homology, Nucleic Acid; D012846:Singapore
chemical_list: D018076:DNA, Complementary; D015236:HLA-C Antigens; C119147:HLA-C*04:06 antigen