The effect of naltrexone on taste detection and recognition threshold.
Eighteen healthy female volunteers were administered 50 mg naltrexone in a double-blind, placebo control study. Relative taste detection and recognition thresholds for sweet, salty, sour and bitter taste and liking for and perception of sucrose solutions were determined at baseline and 1 hour after administration of naltrexone. Naltrexone did not alter relative taste detection and recognition thresholds for any of the four tastes or perception of sweetness. However, a significant, but slight, decrease in liking for sucrose solutions occurred after naltrexone administration. These findings suggest that opioid-dependent intake is independent of changes in taste perception in humans.
Arbisi
P A
PA
Psychology Service and Department of Psychology, University of Minnesota, Minneapolis, USA.
Billington
C J
CJ
Levine
A S
AS
D000328:Adult; D000704:Analysis of Variance; D004311:Double-Blind Method; D005260:Female; D005502:Food; D006801:Humans; D008568:Memory / Q000187:drug effects*; D008875:Middle Aged; D009271:Naltrexone / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000494:pharmacology*; D010465:Perception / Q000187:drug effects*; D012016:Reference Values; D013652:Taste Threshold / Q000187:drug effects*
D009292:Narcotic Antagonists; D009271:Naltrexone