title: A psychiatric 12-year follow-up of adult patients with neurofibromatosis type 1.
abstract: The impact of neurofibromatosis type 1 (NF1) on psychiatric symptoms and diagnoses, personality variables and self evaluation was studied in a 12 year-follow-up of patients with NF 1 in the city of Göteborg, Sweden. 48 living adult patients with NF1 were re-evaluated in 1990 in a 12 year long time follow up study. The patients were diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders. The following scales were used; the Comprehensive Psychopathological Rating Scale (CPRS), the Karolinska Scales of Personality inventory (KSP) and the Self-Evaluation Scale (SES). A significant psychopathology was found in the NFI patients, p <0.001. One third of the patients were affected by a psychiatric disease, 21% by dysthymia. There was no significant progress in psychiatric symptoms in the follow up period. The personality profile disclosed a heightened self-esteem. The chronic stigmatizing character of NF1 may be the reason for the increased psychopathology found.
authors: Department of Clinical Neuroscience, Göteborg University, Sweden. madeleine.zoller@ms.se
authors: M E
authors: ME
authors: Zöller
authors: B
authors: B
authors: Rembeck
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis* / Q000209:etiology* / Q000523:psychology; D008875:Middle Aged; D009456:Neurofibromatosis 1 / Q000175:diagnosis* / Q000523:psychology*; D010554:Personality Disorders / Q000175:diagnosis* / Q000209:etiology* / Q000523:psychology; D010555:Personality Inventory; D011569:Psychiatric Status Rating Scales; D012647:Self-Assessment; D012720:Severity of Illness Index; D013997:Time Factors