title: The relationship between cerebral infarction and angiographic characteristics in childhood moyamoya disease.
abstract: OBJECTIVE
  In childhood-onset moyamoya disease, the angiographic disease process of stenoocclusive lesions is progressive, and cerebral infarctions often develop as a result of ischemia. Our purpose was to determine how the severity of stenoocclusive lesions in the anterior and posterior circulations affects the distribution of cerebral infarction in patients with childhood-onset moyamoya disease.
  
  
  METHODS
  In 69 patients with childhood-onset moyamoya disease, angiograms were reviewed for stenoocclusive lesions, and CT scans, MR images, or both were reviewed for the sites and extent of cerebral infarction. The relationship between the angiographic and CT/MR findings was examined.
  
  
  RESULTS
  The prevalence and degree of stenoocclusive lesions of the posterior cerebral artery (PCA) significantly correlated with the extent of lesions around the terminal portion of the internal carotid artery (ICA). The prevalence of infarction significantly correlated with the degree of stenoocclusive changes of both the ICA and PCA. Infarctions tended to be distributed in the anterior borderzone in less-advanced cases, while in more advanced cases lesions were additionally found posteriorly in the territory of the middle cerebral artery, the posterior borderzone, and the PCA territory.
  
  
  CONCLUSIONS
  Our results indicate that progressive changes of the anterior and posterior circulations are associated with the distribution of cerebral infarction, culminating in a patchily disseminated or honeycomb pattern of infarction on CT and MR studies in late stages of the disease.
authors: Department of Radiology, Tohoku University School of Medicine, Sendai, Japan.
authors: S
authors: S
authors: Mugikura
authors: S
authors: S
authors: Takahashi
authors: S
authors: S
authors: Higano
authors: R
authors: R
authors: Shirane
authors: N
authors: N
authors: Kurihara
authors: S
authors: S
authors: Furuta
authors: M
authors: M
authors: Ezura
authors: A
authors: A
authors: Takahashi
mesh_terms: D000293:Adolescent; D000328:Adult; D002343:Carotid Artery, Internal / Q000000981:diagnostic imaging / Q000473:pathology; D002533:Cerebral Angiography; D002536:Cerebral Arteries / Q000000981:diagnostic imaging / Q000473:pathology; D002544:Cerebral Infarction / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging*; D002648:Child; D002675:Child, Preschool; D003097:Collateral Circulation; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D009072:Moyamoya Disease / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed