title: Clinical and EEG findings in complex partial status epilepticus with tiagabine.
abstract: A case of complex partial status epilepticus (CPSE) with high dose treatment of tiagabine (TGB) is reported. Seizure aggravation and CPSE developed after stepwise increase of TGB to a dose of 60 mg per day as add-on treatment to carbamazepine (CBZ) 1200 mg/day and vigabatrine (VGB) 1000 mg/day. The EEG during CPSE showed bilateral rhythmic slow activity. Clinical symptoms of CPSE and the EEG normalized after i.v. treatment with clonazepam. The literature and the possible mechanism of this paradoxical phenomenon are discussed.
authors: Department of Neurology, Landesnervenklinik Salzburg, Ignaz, Austria.
authors: E
authors: E
authors: Trinka
authors: T
authors: T
authors: Moroder
authors: M
authors: M
authors: Nagler
authors: W
authors: W
authors: Staffen
authors: W
authors: W
authors: Löscher
authors: G
authors: G
authors: Ladurner
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D002220:Carbamazepine / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004569:Electroencephalography / Q000187:drug effects*; D017029:Epilepsy, Complex Partial / Q000175:diagnosis* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D009557:Nipecotic Acids / Q000627:therapeutic use*; D000078308:Tiagabine; D020888:Vigabatrin; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D009557:Nipecotic Acids; D002220:Carbamazepine; D005680:gamma-Aminobutyric Acid; D020888:Vigabatrin; D000078308:Tiagabine