Pharmacokinetics of oral zidovudine entrapped in biodegradable nanospheres in rabbits.
The pharmacokinetic profile of oral zidovudine entrapped in a 50:50 polyactide-coglycolide matrix (nanospheres) was compared to those of standard oral and parenteral zidovudine formulations in rabbits. The bioavailability of zidovudine nanospheres at 50 mg/kg of body weight was 76%, and this dose achieved prolonged exposure to zidovudine compared to standard formulations without an increase in the drug's peak concentration.
Callender
D P
DP
Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA.
Jayaprakash
N
N
Bell
A
A
Petraitis
V
V
Petraitiene
R
R
Candelario
M
M
Schaufele
R
R
Dunn
J M
JM
Sei
S
S
Walsh
T J
TJ
Balis
F M
FM
Petratienes
R
R
D000818:Animals; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D019540:Area Under Curve; D001673:Biodegradation, Environmental; D001835:Body Weight; D004337:Drug Carriers; D008863:Microspheres; D011817:Rabbits; D015215:Zidovudine / Q000008:administration & dosage / Q000493:pharmacokinetics*
D019380:Anti-HIV Agents; D004337:Drug Carriers; D015215:Zidovudine