title: Subacute measles encephalitis in a young man immunosuppressed for ankylosing spondylitis.
abstract: Subacute measles encephalitis occurred 1 month after measles onset in a 26-year-old HIV-negative man undergoing immunosuppressive treatment for ankylosing spondylitis. He had seizures, a decline in mental status, and progressive impairment of consciousness, with a fatal outcome. Despite severely deficient cellular immunity, the elevated antimeasles antibody titers and CSF findings indicated that humoral immunity was not impaired. Histologic, electron microscopic, and immunocytochemical studies revealed the typical intranuclear inclusions of paramyxovirus nucleocapsids, and measles virus antigen in neurons and oligodendrocytes.
authors: Department of Neurological Sciences and Rehabilitation, University of Genoa, Italy.
authors: P
authors: P
authors: Gazzola
authors: L
authors: L
authors: Cocito
authors: E
authors: E
authors: Capello
authors: L
authors: L
authors: Roccatagliata
authors: M
authors: M
authors: Canepa
authors: G L
authors: GL
authors: Mancardi
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology; D018792:Encephalitis, Viral / Q000150:complications* / Q000473:pathology; D006801:Humans; D007165:Immunosuppression Therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D008457:Measles / Q000150:complications*; D013167:Spondylitis, Ankylosing / Q000150:complications*