title: [Acne in the male resistant to isotretinoin and responsibility of androgens: 9 cases, therapeutic implications].
abstract: BACKGROUND
  Treatment failures with isotretinoin in female patients are frequently related to endocrinological dysfunctions. Such a concept has never been discussed in male patients.
  
  
  METHODS
  An extensive endocrinological work-up has been performed in nine male patients who presented with an acne refractory to conventional treatment and to isotretinoin. Adrenal dysfunction was found in four patients and isolated 5-alpha reductase hyperactivity in 2 cases. Three work-ups were normal. A suppressive treatment in three patients with adrenal dysfunction provided immediate efficacy.
  
  
  CONCLUSIONS
  These results would provide insight into the mechanism of refractory acne in men.
authors: Service d'Endocrinologie, Hôpital Saint-Louis, Paris.
authors: C
authors: C
authors: Chaspoux
authors: D
authors: D
authors: Lehucher-Ceyrac
authors: P
authors: P
authors: Morel
authors: H
authors: H
authors: Lefrancq
authors: P
authors: P
authors: Boudou
authors: J
authors: J
authors: Fiet
authors: P
authors: P
authors: Vexiau
mesh_terms: D000152:Acne Vulgaris / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D000293:Adolescent; D000328:Adult; D000728:Androgens / Q000097:blood; D003937:Diagnosis, Differential; D004351:Drug Resistance; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D015474:Isotretinoin / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D017211:Treatment Failure
chemical_list: D000728:Androgens; D015474:Isotretinoin