Preliminary experience with interactive guided brain biopsies using a vertically opened 0.5-T MR system.
The purpose of our study was to evaluate the feasibility and accuracy of brain biopsies performed within a vertically opened MR system. We worked with the interventional 0.5-T MR "SIGNA SP" (General Electric Medical Systems, Milwaukee, Wis.) with an integrated tracking device "Flashpoint Position Encoder" (Image Guided Technologies, USA). As a holding device for this instrument we constructed a special frame. The whole system allows an exact adjustment of an optimum biopsy direction and guidance of the biopsy in a non-stereotactic, interactive mode in near real-time. As biopsy tools we used MR-compatible aspiration and specially made side-cut needles (Daum, Germany; E-Z-EM, USA). We performed a prospective diagnostic brain biopsy study in 18 patients. Guidance of the needle was carried out using gradient-echo single-slice technique. The sample was taken after controlling the exact position of the needle tip on spin-echo images. In 12 cases an exact neuropathological diagnosis was possible. In 6 cases of negative biopsy (4 aspiration biopsies) the samples were not representative. Our results demonstrate the feasibility of interactive MR-guided minimally invasive brain biopsies in an open MR system. The best results were achieved using cut needles for biopsies of contrast-enhancing lesions visible on T1-weighted gradient-echo guidance sequence.
Schneider
J P
JP
Department of Diagnostic Radiology, University of Leipzig, Germany.
Dietrich
J
J
Lieberenz
S
S
Schmidt
F
F
Sorge
O
O
Trantakis
C
C
Seifert
V
V
Kellermann
S
S
Schober
R
R
Franke
P
P
D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000473:pathology; D001707:Biopsy, Needle / Q000379:methods*; D001921:Brain / Q000473:pathology*; D001922:Brain Abscess / Q000473:pathology*; D001932:Brain Neoplasms / Q000473:pathology*; D003937:Diagnosis, Differential; D005240:Feasibility Studies; D005260:Female; D005909:Glioblastoma / Q000473:pathology; D006801:Humans; D007089:Image Enhancement; D008223:Lymphoma / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results