Effects of tropisetron, a 5-HT3 receptor antagonist, on proximal gastric motor and sensory function in nonulcer dyspepsia.
BACKGROUND
Visceral hypersensitivity is claimed to be involved in the pathogenesis of nonulcer dyspepsia (NUD). In a double-blind crossover study, we evaluated the effects of tropisetron, a 5-HT3 receptor antagonist, on gastric accommodation, reflex relaxation, and sensitivity in NUD patients.


METHODS
Eight patients and 10 healthy controls received placebo or 5 mg tropisetron on separate days. On each day, gastric accommodation and relaxation were investigated using a gastric barostat. The perception during gastric distension and relaxation was scored by a verbal perception score.


RESULTS
Under both medications, gastric accommodation and postprandial gastric reflex relaxation were not impaired in the NUD patients. The visceral perception was increased in the NUD patients and not substantially influenced by tropisetron.


CONCLUSIONS
Tropisetron does not influence gastric accommodation, reflex relaxation, or gastric sensitivity in NUD patients and healthy controls.
Klatt
S
S
Department of Internal Medicine I, University of Ulm, Germany.
Böck
W
W
Rentschler
J
J
Beckh
K
K
Adler
G
G
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004415:Dyspepsia / Q000503:physiopathology*; D017615:Enteric Nervous System / Q000187:drug effects; D005260:Female; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D010465:Perception; D011312:Pressure; D012018:Reflex / Q000187:drug effects; D012684:Sensory Thresholds; D012702:Serotonin Antagonists / Q000494:pharmacology*; D018709:Statistics, Nonparametric; D013270:Stomach / Q000187:drug effects* / Q000294:innervation / Q000503:physiopathology; D000077526:Tropisetron
D007211:Indoles; D012702:Serotonin Antagonists; D000077526:Tropisetron