Functional pulmonary surfactant deficiency and neonatal respiratory disorders.
The pathophysiology of functional deficiency of pulmonary surfactant in the neonatal respiratory disorders represented by MAS, hemorrhagic lung edema and ARDS was discussed. The removal of inhibitor(s) is the cardinal procedure for MAS and the lavage with surfactant solution seems to be promising. In case of replacement therapy, we should consider using a different dose compared to the one used in RDS due to lung immaturity, in order to optimize results.
Ogawa
Y
Y
Department of Pediatrics Saitama Medical Center, Saitama Medical School, Kawagoe, Japan. yjogawa@saitama-med.ac.jp
Shimizu
H
H
Itakura
Y
Y
Ohama
Y
Y
Arakawa
H
H
Amizuka
T
T
Obata
M
M
Kakinuma
R
R
D006801:Humans; D007231:Infant, Newborn; D008171:Lung Diseases / Q000209:etiology*; D008471:Meconium Aspiration Syndrome / Q000209:etiology*; D011663:Pulmonary Surfactants / Q000172:deficiency*; D012127:Respiratory Distress Syndrome, Newborn / Q000209:etiology*; D012140:Respiratory Tract Diseases / Q000209:etiology*
D011663:Pulmonary Surfactants