How do NK cells sense the expression of HLA-G class Ib molecules?
The nature of NK cell receptors involved in recognition of HLA-G1 has remained an unclear issue; we herein review this topic based on our experience. We found no evidence that well characterized p58 and p70 KIRs may interact with HLA-G1. By contrast, our data support that NK recognition of cells expressing HLA-G1 involves at least two non-overlapping receptor-ligand systems: (1) the direct engagement of the ILT2 (LIR1) receptor by HLA-G1; and (2) the interaction of CD94/NKG2A and CD94/NKG2C receptors with the non-classical class I molecule HLA-E, co-expressed on the surface upon binding to a nonamer (VMAPRTLFL) from the HLA-G leader sequence.
López-Botet
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Servicio de Inmunología, Hospital Universitario de la Princesa, Diego de León 62, Madrid, 28006, Spain.
Navarro
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Llano
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D015703:Antigens, CD / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D007132:Immunoglobulin Isotypes / Q000235:genetics / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology*; D037102:Lectins / Q000276:immunology; D037181:Lectins, C-Type; D008562:Membrane Glycoproteins / Q000276:immunology; D005810:Multigene Family; D051920:NK Cell Lectin-Like Receptor Subfamily D; D011975:Receptors, Mitogen / Q000276:immunology; D000097625:HLA-E Antigens
D015703:Antigens, CD; D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; D007132:Immunoglobulin Isotypes; D037102:Lectins; D037181:Lectins, C-Type; D008562:Membrane Glycoproteins; D051920:NK Cell Lectin-Like Receptor Subfamily D; D011975:Receptors, Mitogen; D000097625:HLA-E Antigens; C497869:KLRD1 protein, human