Successful treatment of candidal osteomyelitis with fluconazole following failure with liposomal amphotericin B.
A case of multiple relapses of Candida albicans infection of deep tissues is described. Treatment was complicated by renal impairment, but therapy with a liposomal amphotericin product failed to eradicate the third recurrence which subsequently resolved after protracted exposure to oral fluconazole.
Turner
D L
DL
Department of Haematological Medicine, Taunton & Somerset NHS Trust, UK.
Johnson
S A
SA
Rule
S A
SA
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use; D002176:Candida albicans / Q000187:drug effects; D002177:Candidiasis / Q000150:complications / Q000188:drug therapy*; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use*; D006801:Humans; D008081:Liposomes / Q000627:therapeutic use; D010019:Osteomyelitis / Q000188:drug therapy* / Q000209:etiology; D012008:Recurrence
D000935:Antifungal Agents; D008081:Liposomes; C068538:liposomal amphotericin B; D000666:Amphotericin B; D015725:Fluconazole