Propionic acid production by extractive fermentation. I. Solvent considerations.
Solvent selection for extractive fermentation for propionic acid was conducted with three systems: Alamine 304-1 (trilaurylamine) in 2-octanol, 1-dodecanol, and Witcohol 85 NF (oleyl alcohol). Among them, the solvent containing 2-octanol exhibited the highest partition coefficient in acid extraction, but it was also toxic to propionibacteria. The most solvent-resistant strain among five strains of the microorganism was selected. Solvent toxicity was eliminated via two strategies: entrapment of dissolved toxic solvent in the culture growth medium with vegetable oils such as corn, olive, or soybean oils; or replacement of the toxic 2-octanol with nontoxic Witcohol 85 NF. The complete recovery of acids from the Alamine 304-1/Witcohol 85 NF was also realized with vacuum distillation.
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Department of Chemical Engineering, Iowa State University, Ames, Iowa 50011-2230, USA.
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D005285:Fermentation; D011422:Propionates / Q000138:chemical synthesis* / Q000737:chemistry; D011424:Propionibacterium / Q000187:drug effects / Q000378:metabolism; D012997:Solvents / Q000737:chemistry* / Q000633:toxicity; D013045:Species Specificity
D011422:Propionates; D012997:Solvents; C029658:propionic acid