Peripheral blood stem cell transplantation for non-Hodgkin's lymphoma in complete remission.
High-dose chemotherapy with PBSCT as consolidation therapy was administered to 15 patients with non-Hodgkin's lymphoma admitted to our department between November 1991 and March 1998. The average number of CD34-positive cells harvested was 3.1 x 10(6)/kg and the median time to a granulocyte count above 500/microliter was 12.8 days. Of the patients, one died from cytomegalovirus pneumomonia after WBC count recovered, 2 relapsed, and 12 patients are still alive and disease-free. The average disease-free survival period was 50.0 months. Stem cell harvesting is relatively simple and hematopoietic recovery is mory rapid with PBSCT than with ABMT. Our findings suggest that PBSCT can be used for consolidation therapy in NHL patients who have achieved complete remission with standard chemotherapy.
Yamane
T
T
Department of Clinical Hematology, Osaka City University of Medical School, Japan. yamane@msic.med.osaka-cu.ac.jp
Hino
M
M
Ohta
K
K
Nakao
T
T
Nakamae
H
H
Yamamura
R
R
Takubo
T
T
Tatsumi
N
N
D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012074:Remission Induction