title: Psychotic illness after prenatal exposure to the 1953 Dutch Flood Disaster.
abstract: We tested the hypothesis that maternal stress during pregnancy increases the risk of non-affective psychosis for the child. The concept of non-affective psychosis includes the ICD categories schizophrenic disorder, paranoid state and other non-organic psychosis. Data from the Dutch Psychiatric Registry were examined for an effect of the Flood Disaster of 1 February 1953. On this day, a gale caused a flood in the South-west of The Netherlands and 1835 people perished. Our study concerned the 19 villages where mortality exceeded 0.25%. The risk of non-affective psychosis for the cohort born in the period February-October 1953 was compared to the risks for the cohorts born in the corresponding periods of the previous and subsequent 2 years. The relative risk of non-affective psychosis for those exposed during gestation was 1.8 [95% Confidence Interval (CI): 0.9-3.5]. Thus, our study failed to demonstrate a significant association between prenatal exposure to maternal stress and risk of non-affective psychosis. The possible explanations for this finding are discussed.
authors: Department of Psychiatry, University of Utrecht, The Netherlands.
authors: J P
authors: JP
authors: Selten
authors: Y
authors: Y
authors: van der Graaf
authors: R
authors: R
authors: van Duursen
authors: C C
authors: CC
authors: Gispen-de Wied
authors: R S
authors: RS
authors: Kahn
mesh_terms: D015331:Cohort Studies; D004190:Disasters; D005260:Female; D006801:Humans; D008297:Male; D018811:Maternal Exposure; D009426:Netherlands / Q000453:epidemiology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011618:Psychotic Disorders / Q000453:epidemiology*; D012042:Registries; D012559:Schizophrenia / Q000453:epidemiology*; D013315:Stress, Psychological / Q000523:psychology