Preproenkephalin mRNA and enkephalin levels in the adult Syrian hamster: the influence from glucocorticoids.
Proenkephalin (Penk) gene structure in hamsters and humans are similar but they differ from rats. In this study hamster Penk gene expression was examined after hypophysectomy+/-glucocorticoid receptor blockade with RU 486 (mifepristone). In contrast to rats, basal Penk gene expression in hamster adrenals did not change after treatments that reduced both the influence from glucocorticoids and phenylethanolamine-N-methyltransferase mRNA levels. Meanwhile, striatal preproenkephalin mRNA levels increased under these conditions.
Jimenez
R
R
Department of Pharmacology, Cornell University Medical College, 1300 York Avenue, New York, NY 10021, USA.
Yoburn
B C
BC
Calvano
S E
SE
Franklin
S O
SO
D000311:Adrenal Glands / Q000737:chemistry / Q000502:physiology; D000367:Age Factors; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects* / Q000235:genetics; D003342:Corpus Striatum / Q000737:chemistry / Q000502:physiology; D006224:Cricetinae; D004745:Enkephalins / Q000235:genetics*; D015870:Gene Expression / Q000187:drug effects / Q000502:physiology; D005938:Glucocorticoids / Q000494:pharmacology*; D006727:Hormone Antagonists / Q000494:pharmacology; D007016:Hypophysectomy; D008297:Male; D008647:Mesocricetus; D015735:Mifepristone / Q000494:pharmacology; D011498:Protein Precursors / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats
D004745:Enkephalins; D005938:Glucocorticoids; D006727:Hormone Antagonists; D011498:Protein Precursors; D012333:RNA, Messenger; D015735:Mifepristone; C033660:preproenkephalin