title: Cytogenetic and morphologic characteristics of gastrointestinal stromal tumors. Recurrent rearrangement of chromosome 1 and losses of chromosomes 14 and 22 as common anomalies.
abstract: We present cytogenetic findings in five gastrointestinal stromal tumors (GISTs). Three of these five cases had abnormal karyotypes with clonal chromosomal aberrations. The most common karyotypic pattern was a combined loss of chromosomes 14 and 22 in a total of three cases. Among these cases, additional recurrent chromosomal abnormalities were loss of 1p and/or 9, detected in two cases each. Another karyotypic feature consisted of polyploidisation, leading to hypotetraploid chromosome numbers in one case. These cytogenetic results provide evidence for a characteristic karyotypic pattern consisting of -14 and -22 in a subset of GISTs.
authors: Institute of Pathology, Rheinisch-Westfälische Technische Hochschule Aachen.
authors: F
authors: F
authors: Bergmann
authors: B
authors: B
authors: Gunawan
authors: B
authors: B
authors: Hermanns
authors: J
authors: J
authors: Höer
authors: V
authors: V
authors: Schumpelick
authors: L
authors: L
authors: Füzesi
mesh_terms: D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D002883:Chromosomes, Human, Pair 14; D002892:Chromosomes, Human, Pair 22; D005770:Gastrointestinal Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007621:Karyotyping; D019656:Loss of Heterozygosity; D011003:Ploidies; D012983:Soft Tissue Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery