Ethanol induced differences in medial prefrontal cortex dopamine asymmetry and in nucleus accumbens dopamine metabolism in left- and right-turning rats.
Ethanol (0.5 g/kg i.p.) 15 min prior to sacrifice increased homovanillic acid (HVA) levels in the left medial prefrontal cortex (mPFC) of left-turning rats and in the right mPFC of right-turning rats. In the nucleus accumbens (NAS), ethanol decreased dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), and HVA levels in rats that exhibited low levels of locomotor activity but not in rats that exhibited high levels of locomotor activity. This laboratory has previously shown that rats exhibiting differences in turning and locomotor activity behavior display different preferences for ethanol. The present results suggest that ethanol-induced differences in mPFC and NAS DA activity may be related to individual differences in the susceptibility to abuse ethanol.
Nielsen
D M
DM
Department of Pharmacology and Neuroscience, Mail Code 136, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA.
Crosley
K J
KJ
Keller
R W
RW
Glick
S D
SD
Carlson
J N
JN
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D000431:Ethanol / Q000494:pharmacology*; D007839:Functional Laterality / Q000502:physiology*; D006719:Homovanillic Acid / Q000378:metabolism; D008297:Male; D009714:Nucleus Accumbens / Q000378:metabolism*; D017397:Prefrontal Cortex / Q000378:metabolism*; D051381:Rats; D020318:Rats, Long-Evans; D013239:Stereotyped Behavior / Q000502:physiology*; D014018:Tissue Distribution
D015102:3,4-Dihydroxyphenylacetic Acid; D000431:Ethanol; D004298:Dopamine; D006719:Homovanillic Acid