title: Tissue oxygen distribution in head and neck cancer patients.
abstract: BACKGROUND
  The importance of hypoxia in limiting the sensitivity of tumor cells to ionizing radiation has long been known.
  
  
  METHODS
  We evaluated the tissue oxygenation status with a polarographic needle electrode system in 37 patients with malignancies of the head and neck and correlated the pO2 of 25 patients with treatment outcome.
  
  
  RESULTS
  Sixteen tumors contained areas of severe hypoxia, defined by pO2 values below 2.5 mm Hg. Tumor oxygenation parameters were not correlated with hemoglobin, age, and history of tobacco use. There were no subcutaneous PO2 values below 10 mm Hg (ie, no areas of moderate or severe hypoxia), whereas this degree of hypoxia was commonly found in the tumors. Though not statistically significant, hypoxic tumors showed trends for poorer treatment outcome.
  
  
  CONCLUSIONS
  Our data demonstrate a great interindividual variability in the oxygenation of head and neck cancers and appears unassociated with clinical parameters. The method is capable of identifying patients with poorly oxygenated tumors, thereby providing important information for selecting patients who might need customized therapy designed to kill hypoxic tumor cells. Hypoxic tumors show a consistent trend for poor treatment outcome.
authors: Department of Radiation Oncology/Division of Radiation Biology, Stanford University Medical School, California, USA.
authors: M F
authors: MF
authors: Adam
authors: E C
authors: EC
authors: Gabalski
authors: D A
authors: DA
authors: Bloch
authors: J W
authors: JW
authors: Oehlert
authors: J M
authors: JM
authors: Brown
authors: A A
authors: AA
authors: Elsaid
authors: H A
authors: HA
authors: Pinto
authors: D J
authors: DJ
authors: Terris
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000378:metabolism* / Q000401:mortality / Q000628:therapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000097:blood / Q000378:metabolism* / Q000401:mortality / Q000628:therapy; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008198:Lymph Nodes / Q000378:metabolism; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009333:Neck; D010100:Oxygen / Q000032:analysis*; D011048:Polarography; D015996:Survival Rate
chemical_list: D006454:Hemoglobins; D010100:Oxygen