Prehepatic metabolism of drugs--a mechanism for low and variable oral bioavailability.
Hoppu
K
K
Children's Hospital, University of Helsinki, Finland. Kalle.Hoppu.@huch.fi
D000284:Administration, Oral; D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases; D001682:Biological Availability; D051544:Cytochrome P-450 CYP3A; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004347:Drug Interactions; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D010089:Oxidoreductases, N-Demethylating / Q000378:metabolism
D003577:Cytochrome P-450 Enzyme System; D001189:Aryl Hydrocarbon Hydroxylases; D051544:Cytochrome P-450 CYP3A; D010089:Oxidoreductases, N-Demethylating