Synthesis and thromboxane A2 antagonistic activity activity of indane derivatives.
A new series of indane derivatives were prepared and evaluated for their thromboxane A2 (TXA2, 1) antagonistic activity. Among these compounds, 24a (Z-335) was found to be a potent TXA2 antagonist in oral administration.
Shinozaki
K
K
Central Research Laboratories, Zeria Pharmaceutical Co., Ltd., Ohsatogun, Saitama, Japan.
Sato
H
H
Iwakuma
T
T
Sato
R
R
Kurimoto
T
T
Yoshida
K
K
D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000502:physiology; D007189:Indans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D013928:Thromboxane A2 / Q000037:antagonists & inhibitors*
D007189:Indans; D010975:Platelet Aggregation Inhibitors; D013928:Thromboxane A2