The characteristics of extended-spectrum beta-lactamases in Korean isolates of Enterobacteriaceae.
Extended-spectrum beta-lactamases (ESBLs) in gram-negative organisms have been implicated as the enzymes responsible for resistance to oxyimino-cephalosporins. The incidence of ESBL-producers in Korean isolates of Escherichia coli and Klebsiella pneumoniae were in the range of 4.8-7.5% and 22.5-22.8%, respectively. The ESBL-producing isolates revealed variable levels of resistance to cefotaxime, ceftazidime and aztreonam. They also showed the elevated MIC values of non-beta-lactam antibiotics. SHV-12 and SHV-2a were the enzymes most frequently found in K. pneumoniae strains, but TEM-52 was the most prevalent in E. coli isolates. About 15% of ESBL-producing isolates of Enterobacteriaceae produced CMY-1 enzyme, which conferred resistance to cephamycins such as cefoxitin as well as oxyimino-cephalosporins. Thus, the most common types of ESBLs in Korea are TEM-52, SHV-12 SHV-2a, and CMY-1.
Pai
H
H
Department of Internal Medicine, College of Medicine, Dankook University, Chonan, Korea. paihj@unitel.co.kr
D004352:Drug Resistance, Microbial / Q000502:physiology; D004755:Enterobacteriaceae / Q000737:chemistry* / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000382:microbiology; D006801:Humans; D007723:Korea; D001618:beta-Lactamases / Q000032:analysis*
D001618:beta-Lactamases