title: Effects of irradiation on facial development in mouse embryos.
abstract: The purpose of this study was to observe the effects of irradiation on the craniofacial development of NMRI mouse embryos. Two populations of pregnant mice were irradiated with a single dose of 2 Gray on day 8 of gestation for the first population (Po. 1) and on day 9 of gestation for the second population (Po. 2). On gestational days 9 to 17, embryos were submitted to histological and scanning electron microscope examinations. The two populations of embryos presented a high percentage of centro-facial hypoplasia (74.7% for Po. 1 and 75% for Po. 2) which was more pronounced in the latter one. Ocular anomalies were present in 16% of the first population. Cases of anencephaly, cleft palate and anomalies of the central nervous system were found in both populations.
authors: Laboratoire d'Anatomie et d'Embryologie humaines, Université Libre de Bruxelles, Brussels, Belgium.
authors: R
authors: R
authors: Glineur
authors: S
authors: S
authors: Louryan
authors: C
authors: C
authors: Philippson
authors: L
authors: L
authors: Evrard
authors: L
authors: L
authors: de Vos
mesh_terms: D000016:Abnormalities, Radiation-Induced / Q000473:pathology*; D000757:Anencephaly / Q000209:etiology; D000818:Animals; D016923:Cell Death / Q000502:physiology; D002490:Central Nervous System / Q000002:abnormalities; D002972:Cleft Palate / Q000209:etiology; D004622:Embryo, Mammalian / Q000502:physiology / Q000528:radiation effects; D005124:Eye Abnormalities / Q000209:etiology; D005145:Face / Q000196:embryology* / Q000528:radiation effects*; D005865:Gestational Age; D051379:Mice / Q000196:embryology*; D008815:Mice, Inbred Strains; D008855:Microscopy, Electron, Scanning