MHC multimerization, antigen expression and the induction of APC amnesia in the developing immune response.
Class II multimer formation is an important event in immune recognition. Not only is multimerization a prerequisite for T cell activation, but it is a signal to APC. In the present article, we propose that multimerization can result in the specific removal of ligand complexes from the cell surface of the APC, an event which may influence the overall pattern of T cell reactivity.
Lake
R A
RA
University Department of Medicine, Queen Elizabeth II Medical School, Nedlands, Perth, Australia. rlake@cyllene.uwa.edu.au
Robinson
B W
BW
Hayball
J D
JD
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008024:Ligands; D008954:Models, Biological; D011487:Protein Conformation; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D017634:Self Tolerance; D013601:T-Lymphocytes / Q000276:immunology
D000949:Histocompatibility Antigens Class II; D008024:Ligands; D011948:Receptors, Antigen, T-Cell