title: Cyclic nucleotide-gated cation channel expression in embryonic chick brain.
abstract: Cyclic nucleotide-gated cation channels mediate sensory transduction in vertebrate photoreceptors and olfactory epithelium. These channels are also present in some non-sensory cells, but little is known of their physiological roles outside sensory systems. Using in situ hybridization we found that cyclic nucleotide channel mRNA is expressed specifically in the embryonic chicken forebrain, thalamus, optic tectum, basal midbrain and hindbrain, as well as in the branchial arches, limb buds and skin. Cyclic nucleotide gated channels may thus contribute to development or to cellular differentiation in the brain and in other tissues.
authors: Section of Cardiology, San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA. lct@itsa.ucsf.edu
authors: L C
authors: LC
authors: Timpe
authors: K L
authors: KL
authors: Jin
authors: L
authors: L
authors: Puelles
authors: J L
authors: JL
authors: Rubenstein
mesh_terms: D000818:Animals; D001923:Brain Chemistry / Q000235:genetics*; D002642:Chick Embryo; D006152:Cyclic GMP / Q000494:pharmacology*; D018507:Gene Expression Regulation, Developmental; D017403:In Situ Hybridization; D015640:Ion Channel Gating / Q000187:drug effects / Q000502:physiology*; D007473:Ion Channels / Q000235:genetics* / Q000378:metabolism; D009833:Olfactory Pathways / Q000737:chemistry / Q000196:embryology / Q000502:physiology; D016548:Prosencephalon / Q000737:chemistry / Q000196:embryology / Q000502:physiology; D012333:RNA, Messenger / Q000032:analysis; D012249:Rhombencephalon / Q000737:chemistry / Q000196:embryology / Q000502:physiology; D013477:Superior Colliculi / Q000737:chemistry / Q000196:embryology / Q000502:physiology; D013788:Thalamus / Q000737:chemistry / Q000196:embryology / Q000502:physiology
chemical_list: D007473:Ion Channels; D012333:RNA, Messenger; D006152:Cyclic GMP