title: Oxygen depletion-induced dormancy in Mycobacterium bovis BCG.
abstract: Gradual depletion of oxygen causes the shift-down of aerobic growing Mycobacterium bovis BCG to an anaerobic synchronized state of nonreplicating persistence. The persistent culture shows induction of glycine dehydrogenase and alpha-crystallin-like protein and is sensitive to metronidazole.
authors: Institute of Molecular and Cell Biology, Singapore 117609, Republic of Singapore.
authors: A
authors: A
authors: Lim
authors: M
authors: M
authors: Eleuterio
authors: B
authors: B
authors: Hutter
authors: B
authors: B
authors: Murugasu-Oei
authors: T
authors: T
authors: Dick
mesh_terms: D000594:Amino Acid Oxidoreductases / Q000096:biosynthesis; D000693:Anaerobiosis; D003459:Crystallins / Q000096:biosynthesis; D004790:Enzyme Induction; D050789:Glycine Dehydrogenase; D008795:Metronidazole; D009163:Mycobacterium bovis / Q000254:growth & development* / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism*
chemical_list: D003459:Crystallins; D008795:Metronidazole; D000594:Amino Acid Oxidoreductases; D050789:Glycine Dehydrogenase; D010100:Oxygen