title: Complexity in biological signaling systems.
abstract: Biological signaling pathways interact with one another to form complex networks. Complexity arises from the large number of components, many with isoforms that have partially overlapping functions; from the connections among components; and from the spatial relationship between components. The origins of the complex behavior of signaling networks and analytical approaches to deal with the emergent complexity are discussed here.
authors: Department of Pharmacology, Mount Sinai School of Medicine, New York, NY 10029, USA.
authors: G
authors: G
authors: Weng
authors: U S
authors: US
authors: Bhalla
authors: R
authors: R
authors: Iyengar
mesh_terms: D000818:Animals; D002451:Cell Compartmentation; D002462:Cell Membrane / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D003198:Computer Simulation; D003599:Cytoskeleton / Q000502:physiology; D016208:Databases, Factual; D019204:GTP-Binding Proteins / Q000378:metabolism; D005796:Genes; D006801:Humans; D008954:Models, Biological; D016571:Neural Networks, Computer; D009474:Neurons / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D019204:GTP-Binding Proteins