1998 Curt P. Richter Award. Brain mechanisms in cytokine-induced anorexia.
Our research focuses on the mechanisms underlying cytokine action in the central nervous system (CNS) using an integrative and multidisciplinary strategy organized through supracellular (behavioral analysis by computerized monitoring systems), cellular (extracellular and intracellular neurophysiological recording), and molecular (patch-clamp recording, and DNA, RNA and protein analyses) approaches. An integrative strategy that combines computerized meal pattern analyses with cellular and molecular biology approaches allows the study of underlying brain mechanisms in cytokine- and disease-associated anorexia. This paper presents a comprehensive discussion of our laboratory's previously published data on brain mechanisms involved in cytokine-induced anorexia including the relevance of meal pattern analysis (meal size, meal duration, meal frequency, intermeal intervals), modulation of hypothalamic neuronal activity, molecular processes involving ionic conductances, cytokine-cytokine and cytokine-peptide interactions, and modulation of cytokine and peptide/neuropeptide system components (ligands, endogenous inhibitors, receptor subtypes, signal transduction molecules, intracellular mediators) and cytokine feedback systems.
Plata-Salamán
C R
CR
Division of Molecular Biology, School of Life and Health Sciences, University of Delaware, Newark 19716-2590, USA. crps@udel.edu
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D000855:Anorexia / Q000139:chemically induced / Q000503:physiopathology*; D001066:Appetite / Q000187:drug effects; D001363:Awards and Prizes; D001921:Brain / Q000187:drug effects / Q000503:physiopathology*; D015220:Calcium Channels / Q000187:drug effects / Q000502:physiology; D016207:Cytokines / Q000008:administration & dosage / Q000502:physiology* / Q000633:toxicity; D005247:Feeding Behavior / Q000187:drug effects; D019204:GTP-Binding Proteins / Q000502:physiology; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D007031:Hypothalamus / Q000187:drug effects / Q000503:physiopathology; D007276:Injections, Intraventricular; D007375:Interleukin-1 / Q000494:pharmacology / Q000502:physiology / Q000633:toxicity; D008070:Lipopolysaccharides / Q000494:pharmacology / Q000633:toxicity; D008967:Molecular Biology; D009419:Nerve Tissue Proteins / Q000502:physiology; D051381:Rats
D015220:Calcium Channels; D016207:Cytokines; D007375:Interleukin-1; D008070:Lipopolysaccharides; D009419:Nerve Tissue Proteins; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D019204:GTP-Binding Proteins