Effect of drugs influencing central serotonergic mechanisms on pentazocine-induced catalepsy in mice.
Cataleptic effect of pentazocine in mice was affected by pretreatment with dexfenfluramine, fluoxetine, buspirone, p-chlorophenylalanine, cyproheptadine, mianserin, cisapride, ondansetron, pindolol and propranolol. The results suggest that drugs which influence the activity of central serotonergic systems do modulate pentazocine-induced catalepsy in mice.
Umrani
D N
DN
Department of Pharmacology, College of Pharmacy, Nashik, India.
Kasture
S B
SB
Kasture
V S
VS
D000818:Animals; D002375:Catalepsy / Q000139:chemically induced / Q000378:metabolism*; D004347:Drug Interactions; D008297:Male; D051379:Mice; D010423:Pentazocine / Q000633:toxicity*; D012701:Serotonin / Q000378:metabolism*; D018490:Serotonin Agents / Q000494:pharmacology*
D018490:Serotonin Agents; D012701:Serotonin; D010423:Pentazocine