Multiple gamma c-dependent cytokines regulate T-cell development.
Mutations in the common gamma chain (gamma c) of cytokine receptors account for human X-linked severe combined immunodeficiency disease. gamma c contributes to ligand binding and signaling as a component of five cytokine receptors: interleukin-2-receptor (IL-2R), IL-4R, IL-7R, IL-9R and IL-15R. Here, Thomas Malek and colleagues discuss the contribution of individual gamma c-dependent cytokines in both conventional and intraepithelial T-cell development.
Malek
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Dept of Microbiology and Immunology, University of Miami School of Medicine, FL 33136, USA. tmalek@mednet.med.miami.edu
Porter
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D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology / Q000633:toxicity; D002454:Cell Differentiation; D006410:Hematopoiesis / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007378:Interleukins / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D018448:Models, Immunological; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis; D018121:Receptors, Cytokine / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D018123:Receptors, Interleukin / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D016511:Severe Combined Immunodeficiency / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000473:pathology; D013950:Thymus Gland / Q000473:pathology*; D014960:X Chromosome / Q000235:genetics
D000911:Antibodies, Monoclonal; D007378:Interleukins; D016692:Receptors, Antigen, T-Cell, gamma-delta; D018121:Receptors, Cytokine; D018123:Receptors, Interleukin