Down-weighting of multiple affected sib pairs leads to biased likelihood-ratio tests, under the assumption of no linkage.
Greenwood
C M
CM
Bull
S B
SB
D015982:Bias; D002874:Chromosome Mapping / Q000379:methods / Q000706:statistics & numerical data*; D005787:Gene Frequency / Q000235:genetics; D008040:Genetic Linkage / Q000235:genetics*; D006801:Humans; D016013:Likelihood Functions; D016555:Matched-Pair Analysis; D008957:Models, Genetic; D009679:Nuclear Family; D016008:Statistical Distributions