title: Effects of controlled hypotension with sevoflurane anaesthesia on hepatic function of surgical patients.
abstract: The effects of controlled hypotension induced with trimethaphan (TMP), nitroglycerin (TNG) or prostaglandin E1 (PGE1) during sevoflurane anaesthesia on hepatic function were studied in 28 patients undergoing spinal fusion surgery. Patients were randomly divided into three groups to receive TMP (group A, n = 10), TNG (group B, n = 10) or PGE1 (group C, n = 8). Anaesthesia was maintained with N2O and sevoflurane. The mean arterial blood pressure was maintained at 60 mmHg for 90 min. Measurements included arterial ketone body ratio (AKBR-acetoacetate/3-hydroxybutyrate), SGOT, SGPT, LDH, blood glucose and blood gases were made. Measurements were taken before hypotension, 60 min and 90 min after starting hypotension, 60 min after recovery from hypotension and on the post-operative day. AKBR showed no significant change. SGOT, SGPT and LDH were within normal limits. Controlled hypotension induced with TMP, TNG or PGE1 under sevoflurane anaesthesia in surgical patients did not cause hepatocellular damage.
authors: Department of Anaesthesia, Nagasaki Rosai Hospital, Japan.
authors: M
authors: M
authors: Fukusaki
authors: M
authors: M
authors: Miyako
authors: T
authors: T
authors: Hara
authors: T
authors: T
authors: Maekawa
authors: K
authors: K
authors: Yamaguchi
authors: K
authors: K
authors: Sumikawa
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000527:Alprostadil; D000769:Anesthesia, Inhalation; D018685:Anesthetics, Inhalation; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007023:Hypotension, Controlled; D007657:Ketone Bodies / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008099:Liver / Q000201:enzymology*; D008297:Male; D008738:Methyl Ethers; D008875:Middle Aged; D005996:Nitroglycerin; D000077149:Sevoflurane; D013123:Spinal Fusion; D014294:Trimethaphan
chemical_list: D018685:Anesthetics, Inhalation; D001786:Blood Glucose; D007657:Ketone Bodies; D008738:Methyl Ethers; D000077149:Sevoflurane; D014294:Trimethaphan; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000527:Alprostadil; D005996:Nitroglycerin