Expression of norepinephrine and serotonin transporter mRNAs in the rat superior cervical ganglion.
We investigated the gene expression of three monoamine transporters (norepinephrine transporter, NET; serotonin transporter, SERT; and dopamine transporter, DAT) in the rat superior cervical ganglion (SCG). Most of principal ganglion neurons abundantly expressed NET mRNA. In addition, about 30% of principal ganglion neurons also expressed SERT mRNA. However, DAT mRNA expression was not observed there. These results suggest that serotonin as well as norepinephrine works as a neurotransmitter in a subset of principal ganglion neurons.
Nishimura
M
M
Department of Anesthesiology, Osaka University Medical School, 2-2, Yamadaoka Suita, Osaka 565, Japan.
Sato
K
K
Shimada
S
S
Tohyama
M
M
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics*; D050483:Dopamine Plasma Membrane Transport Proteins; D015870:Gene Expression / Q000502:physiology; D017403:In Situ Hybridization; D008125:Locus Coeruleus / Q000737:chemistry / Q000502:physiology; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins / Q000235:genetics; D050484:Norepinephrine Plasma Membrane Transport Proteins; D015345:Oligonucleotide Probes; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D050486:Serotonin Plasma Membrane Transport Proteins; D017783:Superior Cervical Ganglion / Q000737:chemistry* / Q000502:physiology; D027981:Symporters
D002352:Carrier Proteins; D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D050484:Norepinephrine Plasma Membrane Transport Proteins; D015345:Oligonucleotide Probes; D012333:RNA, Messenger; D050486:Serotonin Plasma Membrane Transport Proteins; C493226:Slc6a2 protein, rat; C493216:Slc6a3 protein, rat; C493232:Slc6a4 protein, rat; D027981:Symporters