Technetium-99m complexes of polydentate amine-pyrrole and amine-thiophene ligands.
Novel polydentate amine-pyrrole and amine-thiophene ligands were synthesized and characterized by 1H and 13C NMR spectroscopy. Radiochemical studies with 99mTc were carried out at 0.1-100 microM of technetium. Complexation yields were estimated from thin layer chromatography (TLC), paper electrophoresis, and solvent extraction studies. The 99mTc complexes formed were found to be neutral and lipophilic. Complexes with the corresponding imine-ligands were formed in lower yields. Biodistribution studies of the 99mTc complexes of these ligands showed no significant uptake in brain or heart, and the clearance was mainly through the hepatobiliary system.
Pillai
M R
MR
Radiopharmaceuticals Section, Isotope Division, Bhabha Atomic Research Centre, Mumbai, India. ambi@magnum.barc.ernet.in
Samuel
G
G
Banerjee
S
S
Mathew
B
B
Sarma
H D
HD
Jurisson
S
S
D000818:Animals; D002855:Chromatography, Thin Layer; D004355:Drug Stability; D004590:Electrophoresis, Paper; D005029:Ethylenediamines / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000378:metabolism; D006860:Hydrogen Bonding; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015609:Organotechnetium Compounds / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000378:metabolism; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000378:metabolism; D014018:Tissue Distribution
D005029:Ethylenediamines; D008024:Ligands; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C120322:technetium Tc 99m tris((2-((pyrrol-2-yl)methylamino)ethyl)amino)amine; C120321:technetium Tc 99m tris((2-((thiophen-2-yl)methylamino)ethyl)amino)amine