Treatment of hyperinsulinaemic hypoglycaemia with nifedipine.
We report on two children with mild persistent hyperinsulinaemic hypoglycaemia. In both, oral nifedipine treatment (0.7 and 2.0 mg/kg per day respectively) had a significant clinical effect. In one case, nifedipine monotherapy prevented hypoglycaemia; in the second case, the dosage and the side-effects of other substances could be reduced, thus circumventing surgical therapy.


CONCLUSIONS
Nifedipine treatment has a favourable effect on the clinical course of patients with mild hyperinsulinism. It represents a valuable new substance for the treatment of this disorder.
Eichmann
D
D
University Children's Hospital, Kiel, Germany.
Hufnagel
M
M
Quick
P
P
Santer
R
R
D001786:Blood Glucose / Q000032:analysis; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000150:complications* / Q000188:drug therapy*; D007003:Hypoglycemia / Q000097:blood / Q000150:complications* / Q000188:drug therapy*; D007223:Infant; D009543:Nifedipine / Q000627:therapeutic use*
D001786:Blood Glucose; D002121:Calcium Channel Blockers; D009543:Nifedipine