title: Serum levels of soluble Fas and disease activity in patients with IgA nephropathy.
abstract: Using a sandwich ELISA, we studied 48 patients with IgA nephropathy and 10 patients with diffuse mesangial proliferative glomerulonephritis without IgA deposition (non-IgA PGN) to determine if levels of serum soluble Fas (s-Fas) might reflect the disease activity. The levels of serum s-Fas in patients with the advanced stage of IgA nephropathy were significantly higher than those in patients with the mild stage of the disease, in non-IgA PGN or in healthy controls. The results showed that advanced stage IgA nephropathy patients who showed heavy proteinuria and the presence of urinary casts revealed high levels of serum s-Fas. It was thus suggested that the measurement of serum s-Fas is useful in evaluating the degree of renal injury in patients with IgA nephropathy.
authors: Division of Nephrology, Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan.
authors: I
authors: I
authors: Shou
authors: K
authors: K
authors: Tashiro
authors: A
authors: A
authors: Kurusu
authors: S
authors: S
authors: Kaneko
authors: T
authors: T
authors: Hayashi
authors: M
authors: M
authors: Fukui
authors: I
authors: I
authors: Shirato
authors: K
authors: K
authors: Kubota
authors: Y
authors: Y
authors: Tomino
mesh_terms: D000293:Adolescent; D000328:Adult; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005922:Glomerulonephritis, IGA / Q000097:blood* / Q000276:immunology / Q000473:pathology; D015432:Glomerulonephritis, Membranoproliferative / Q000097:blood / Q000276:immunology / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology; D008297:Male; D008875:Middle Aged; D019014:fas Receptor / Q000097:blood* / Q000276:immunology
chemical_list: D019014:fas Receptor; D003404:Creatinine