title: Logistic regression analysis of low grade spindle cell lesions. A cytologic study.
abstract: OBJECTIVE
  To identify key diagnostic cytologic criteria for various low grade spindle cell lesions.
  
  
  METHODS
  We reviewed 20 synovial sarcomas, 18 benign neural tumors, 10 reparative lesions, 24 other benign and 27 additional malignant low grade spindle cell lesions. All specimens were coded as to the presence or absence of the following variables: high cellularity, tissue fragments, tissue culture appearance, epithelial fragments, vessel fragments, vascular arcades, fibrillar ground substance, myxoid background, microcystic areas, parallel arrangement of nuclei, naked nuclei, single cells, binucleate cells, multinucleate cells, long filamentous cells, short spindle cells, stellate cells, lipoblasts, nuclear pleomorphism, nuclei with pointed ends, comma/fishhook nuclei, cigar-shaped nuclei, ovoid/round nuclei, small nucleoli, large nucleoli, mitotic figures, intranuclear vacuoles and background histiocytes. A logistic regression analysis was performed to identify the variables predictive of malignant lesions, specifically synovial sarcomas, benign neural tumors and reparative lesions.
  
  
  RESULTS
  Statistical analysis selected high cellularity, short spindle cells, small nucleoli and absence of tissue culture appearance as the main criteria for malignant neoplasms. Tissue fragments and high cellularity were selected as the primary criteria and absence of long filamentous cells and of myxoid background as the secondary criteria for synovial sarcomas. It selected fibrillar ground substance and absence of ovoid/round nuclei as the key criteria for benign neural tumors. The presence of a tissue culture appearance was the major criterion for reparative lesions.
  
  
  CONCLUSIONS
  There are many previously described cytologic criteria, but we found that when subjected to statistical analysis, only a few features were significant in the evaluation of low grade spindle cell lesions.
authors: Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA.
authors: K
authors: K
authors: Liu
authors: R K
authors: RK
authors: Dodge
authors: L G
authors: LG
authors: Dodd
authors: L J
authors: LJ
authors: Layfield
mesh_terms: D001706:Biopsy / Q000592:standards; D002277:Carcinoma / Q000473:pathology*; D002466:Cell Nucleolus / Q000473:pathology; D005350:Fibroma / Q000473:pathology; D006391:Hemangioma / Q000473:pathology; D006801:Humans; D016015:Logistic Models; D008938:Mitosis; D009380:Neoplasms, Nerve Tissue / Q000473:pathology*; D009442:Neurilemmoma / Q000473:pathology*; D012509:Sarcoma / Q000473:pathology; D013584:Sarcoma, Synovial / Q000473:pathology*; D012680:Sensitivity and Specificity