title: [Benign proximal esophageal stenosis--mostly a complication of gastroesophageal reflux disease].
abstract: OBJECTIVE
  Benign stenoses can occur anywhere in the oesophagus, but are most common in its distal part as a result of gastro-oesophageal reflux (GOR). It was the aim of this study to evaluate retrospectively the causes and incidence of benign stenosis of the proximal oesophagus (SPR) as well as its endoscopic and drug treatment.
  
  
  METHODS
  Between December 1989 and December 1997 a total of 17,413 patients were referred to the authors' hospital for oesophago-gastroduodenoscopy, 1024 of them (6%) for clarification of heartburn, regurgitation and/or dysphagia. 53 of these patients (5%) were found to have benign stenosis of the oesophagus requiring bougie dilatation, located in the lower third in 29 (55%), in the middle third in six (11%) and in the upper third in 18 (34%) patients. Causes of stenosis in the upper third were peptic stricture in nine (50%), heterotopic gastric mucosa in three (17%), caustic corrosion in three (17%), post-radiation in two (11%), and the result of web formation in one (6%). Endoscopic bougie dilatation was performed in all these patients, those with GOR additionally receiving 40 mg omeprazole daily.
  
  
  RESULTS
  In those patients with nonpeptic benign stenosis/stricture lasting improvement of symptoms was achieved with one to three dilatation. But those with GOR needed a mean of 13 dilatations during a follow-up period averaging 61 months. Barrett's oesophagus (replacement of squamous by columnar epithelium) was found in five patients. No case of dysplasia was discovered. Laparoscopic fundoplication was performed in one woman in whom bougie dilatation had failed. Remission was maintained, as needed, by bougie and omeprazole in eight patients.
  
  
  CONCLUSIONS
  In benign stenosis of the upper oesophagus endoscopic dilatation is the treatment of choice. In cases of peptic aetiology the administration of proton pump inhibitors is the optimal adjuvant method.
authors: Medizinische Klinik II, Städtisches Klinikum Fulda.
authors: D
authors: D
authors: Jaspersen
authors: K L
authors: KL
authors: Diehl
authors: P
authors: P
authors: Geyer
authors: E
authors: E
authors: Martens
authors: H
authors: H
authors: Arps
mesh_terms: D000897:Anti-Ulcer Agents / Q000008:administration & dosage; D003937:Diagnosis, Differential; D004106:Dilatation; D016145:Endoscopy, Digestive System / Q000706:statistics & numerical data; D004940:Esophageal Stenosis / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008297:Male; D009853:Omeprazole / Q000008:administration & dosage; D011446:Prospective Studies; D012189:Retrospective Studies; D018709:Statistics, Nonparametric
chemical_list: D000897:Anti-Ulcer Agents; D009853:Omeprazole