title: Coating titanium implants with bioglass and with hydroxyapatite. A comparative study in sheep.
abstract: This study compares the osteointegration of titanium implants coated with bioglass (Biovetro GSB formula) and with hydroxyapatite (HAP). Twenty-four bioglass-coated and 24 HAP-coated cylinders were implanted in the femoral diaphyses of sheep, and examined after 2, 4, 6, 8, 12, and 16 weeks. The HAP coating gave a stronger and earlier fixation to the bone than did bioglass. Bioglass formed a tissue interface which showed a macrophage reaction with little new bone formation activity. In contrast, HPA, showed intense new bone formation, with highly mineralised osseous trabeculae in the neighbourhood of the interface.
authors: Department of Orthopaedics Surgery, Complejo Hospitalario de León, Spain.
authors: S
authors: S
authors: Lopez-Sastre
authors: J M
authors: JM
authors: Gonzalo-Orden
authors: J A
authors: JA
authors: Altónaga
authors: J R
authors: JR
authors: Altónaga
authors: M A
authors: MA
authors: Orden
mesh_terms: D000818:Animals; D018786:Bone Substitutes / Q000737:chemistry / Q000627:therapeutic use*; D002516:Ceramics / Q000737:chemistry / Q000627:therapeutic use*; D020099:Coated Materials, Biocompatible / Q000627:therapeutic use*; D019245:Compressive Strength; D004353:Drug Evaluation, Preclinical; D017886:Durapatite / Q000737:chemistry / Q000627:therapeutic use*; D006622:Hip Prosthesis; D008264:Macrophages / Q000276:immunology; D016348:Osseointegration; D016062:Porosity; D012756:Sheep; D013718:Tensile Strength; D013997:Time Factors; D014025:Titanium / Q000627:therapeutic use*
chemical_list: C022107:Bioglass; D018786:Bone Substitutes; D020099:Coated Materials, Biocompatible; D017886:Durapatite; D014025:Titanium