Regional and cellular localization of calcitonin gene-related peptide-receptor component protein mRNA in the guinea-pig central nervous system.
Recent cloning studies have isolated proteins which confer responsiveness to calcitonin gene-related peptide (CGRP). In this study, we have determined the central nervous system (CNS) distribution of the mRNA of one such protein, termed CGRP-receptor component protein (RCP), by in situ hybridization. CGRP-RCP mRNA was widely expressed in the guinea-pig CNS, being particularly abundant in cerebellum and hippocampus. These data should assist in the determination of the potential physiological function(s) of this protein in the CNS.
Oliver
K R
KR
Merck, Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terling's Park, Harlow, Essex CM20 2QR, UK. kevin_oliver@merck.com
Wainwright
A
A
Kinsey
A M
AM
Heavens
R P
RP
Sirinathsinghji
D J
DJ
Hill
R G
RG
D000818:Animals; D001923:Brain Chemistry / Q000235:genetics*; D002490:Central Nervous System / Q000737:chemistry / Q000502:physiology; D015870:Gene Expression / Q000502:physiology; D006168:Guinea Pigs; D017403:In Situ Hybridization; D007457:Iodine Radioisotopes; D008297:Male; D015345:Oligonucleotide Probes; D012333:RNA, Messenger / Q000032:analysis; D018015:Receptors, Calcitonin Gene-Related Peptide / Q000235:genetics*
D007457:Iodine Radioisotopes; D015345:Oligonucleotide Probes; D012333:RNA, Messenger; D018015:Receptors, Calcitonin Gene-Related Peptide