HLA-G and HLA-C at the feto-maternal interface: lessons learned from pathogenic viruses.
Immunoevasive viruses which effect antigen presentation by class I major histocompatibility complex (MHC) molecules have helped to broaden our understanding of the intracellular transport and processing of HLA-G and HLA-C in the placenta. Cellular infection with herpes simplex virus (HSV) and human cytomegalovirus (HCMV) are each associated with the downregulation of surface expression of HLA-A and -B, albeit by remarkably distinct mechanisms. Investigations on the effects of HSV and HCMV infection on HLA-G and HLA-C in the trophoblast have revealed both hypothesized similarities and surprising differences between trophoblast and classical class I products.
Schust
D J
DJ
Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Building D2, Room 137, Boston, MA 02115, USA.
Tortorella
D
D
Ploegh
H L
HL
D017951:Antigen Presentation; D003587:Cytomegalovirus / Q000472:pathogenicity*; D015536:Down-Regulation; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D015236:HLA-C Antigens / Q000276:immunology*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D008431:Maternal-Fetal Exchange / Q000276:immunology*; D011247:Pregnancy; D018139:Simplexvirus / Q000472:pathogenicity*
D006680:HLA Antigens; D015236:HLA-C Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I