title: Hepatocellular carcinoma with fibrolamellar pattern in a patient with autoimmune cholangitis.
abstract: A 75-year-old woman with a 15-year history of autoimmune cholangitis underwent orthotopic liver transplantation because of progressive liver decompensation. A clinically unsuspected hepatocellular carcinoma was found. A portion of the tumor showed fibrolamellar differentiation. Hepatocellular carcinoma, either with the usual pattern or with a fibrolamellar pattern, is rare in the setting of primary biliary cirrhosis, but has been seen in the setting of autoimmune hepatitis. Autoimmune cholangitis is a relatively recently recognized form of autoimmune liver disease whose association with hepatocellular carcinoma has yet to be determined.
authors: Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
authors: R C
authors: RC
authors: Singson
authors: M
authors: M
authors: Fraiman
authors: S A
authors: SA
authors: Geller
mesh_terms: D000368:Aged; D001327:Autoimmune Diseases / Q000150:complications* / Q000601:surgery; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000473:pathology; D002761:Cholangitis / Q000150:complications* / Q000276:immunology / Q000601:surgery; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications* / Q000473:pathology; D016031:Liver Transplantation