title: Effect of erythromycin on otitis media with effusion in experimental rat model.
abstract: To understand the mechanism of erythromycin (EM) on otitis media with effusion, we examined its effects on leukocyte accumulation and expression of adhesion molecules L-selectin and Mac-1, using a rat experimental model Administration of EM inhibited leukocyte (neutrophil) accumulation in the middle ear cavity after LPS stimulation. Moreover, EM downregulated L-selectin expression and inhibited interleukin (IL)-8-induced upregulation of Mac-1 on peripheral blood neutrophils. These finding suggests that EM may improve otitis media with effusion by inhibiting neutrophil accumulation in the middle ear cavity through modulating the expression of adhesion molecules L-selectin and Mac-1 on peripheral blood neutrophils.
authors: Department of Otorhinolaryngology, Juntendo University School of Medicine, Tokyo, Japan.
authors: F
authors: F
authors: Enomoto
authors: G
authors: G
authors: Ichikawa
authors: I
authors: I
authors: Nagaoka
authors: T
authors: T
authors: Yamashita
mesh_terms: D000818:Animals; D015536:Down-Regulation; D004432:Ear, Middle / Q000737:chemistry; D004917:Erythromycin / Q000494:pharmacology* / Q000627:therapeutic use; D019041:L-Selectin / Q000032:analysis / Q000187:drug effects*; D016177:Macrophage-1 Antigen / Q000032:analysis / Q000187:drug effects*; D009504:Neutrophils / Q000187:drug effects*; D010034:Otitis Media with Effusion / Q000188:drug therapy* / Q000473:pathology; D051381:Rats; D015854:Up-Regulation
chemical_list: D016177:Macrophage-1 Antigen; D019041:L-Selectin; D004917:Erythromycin