Growth in the presence of salicylate increases fluoroquinolone resistance in Staphylococcus aureus.
Salicylate and acetylsalicylate slightly increased fluoroquinolone resistance in ciprofloxacin-susceptible and -resistant Staphylococcus aureus. Salicylate allowed a greater number of cells from ciprofloxacin-susceptible and -resistant strains to survive on high fluoroquinolone concentrations. Salicylate also increased the frequency with which a susceptible strain mutated to become more resistant to ciprofloxacin.
Gustafson
J E
JE
Microbiology Group, School of Biomedical Sciences, Curtin University of Technology, Western Australia, Australia. tgustafs@alpha2.curtin.edu.au
Candelaria
P V
PV
Fisher
S A
SA
Goodridge
J P
JP
Lichocik
T M
TM
McWilliams
T M
TM
Price
C T
CT
O'Brien
F G
FG
Grubb
W B
WB
D000890:Anti-Infective Agents / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D004347:Drug Interactions; D004352:Drug Resistance, Microbial / Q000235:genetics / Q000502:physiology; D024841:Fluoroquinolones; D008826:Microbial Sensitivity Tests; D012459:Salicylates / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics
D000890:Anti-Infective Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D024841:Fluoroquinolones; D012459:Salicylates