title: An in vitro study on the toxic effects of nonylphenols (NP) in mitochondria.
abstract: This paper is focused on alkylphenols, compounds which are formed by the biodegradation of polyethoxilatedalkylphenols detergents. Our experiments show that alkylphenols act not only as detergents, but also as uncouplers of the oxidative phosphorylation. This effect, can be observed at very low doses, thus suggesting that the preferential target of nonylphenols in living organisms are mitochondria.
authors: Dipartimento di Scienze Ambientali, Università di Venezia, Italy. aleiero@unive.it
authors: M
authors: M
authors: Bragadin
authors: G
authors: G
authors: Perin
authors: A
authors: A
authors: Iero
authors: S
authors: S
authors: Manente
authors: V
authors: V
authors: Rizzoli
authors: G
authors: G
authors: Scutari
mesh_terms: D000818:Animals; D001673:Biodegradation, Environmental; D003902:Detergents / Q000493:pharmacokinetics / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D010636:Phenols / Q000493:pharmacokinetics / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D014475:Uncoupling Agents / Q000378:metabolism
chemical_list: D003902:Detergents; D010636:Phenols; D014475:Uncoupling Agents