[Quantitative analysis of ligand-receptor interactions in physiological experiments].
In isolated smooth muscles of the sea cucumber, the rat intestine, vas deferens and portal vein, and in chick embryonic amnion, contractile responses of smooth muscles to transmitters and their agonists were described with two equations: p = (Pm.A(n))/(EC50n + A(n)) [7] or p = [(Pm1.An1)/(EC50(1)n1 + An1)] + [(Pm2.An2)/(EC50(2)n2 + An2)] [8]. The findings reveal a possibility of ligand-receptor interaction according to several models: a single receptor pool with n = 1 or n not equal to 1; two receptor pools in the same effector system with n1 = n2 or n1 not equal to n2.
Manukhin
B N
BN
N. K. Kol'tsov Institute of Developmental Biology of the Russian Acad. Sci., Moscow, Russia.
Berdysheva
L V
LV
Boĭko
O V
OV
Kichikulova
T P
TP
Nesterova
L A
LA
D000109:Acetylcholine / Q000494:pharmacology; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000650:Amnion / Q000502:physiology; D000818:Animals; D002642:Chick Embryo; D066298:In Vitro Techniques; D007421:Intestine, Small / Q000502:physiology; D007545:Isoproterenol / Q000494:pharmacology; D008024:Ligands; D008297:Male; D008954:Models, Biological; D009119:Muscle Contraction / Q000502:physiology; D009130:Muscle, Smooth / Q000502:physiology*; D009131:Muscle, Smooth, Vascular / Q000502:physiology; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D012082:Renal Veins / Q000502:physiology; D012616:Sea Cucumbers; D014649:Vas Deferens / Q000502:physiology
D000318:Adrenergic beta-Agonists; D008024:Ligands; D011941:Receptors, Adrenergic; D011950:Receptors, Cholinergic; D007545:Isoproterenol; D000109:Acetylcholine; D009638:Norepinephrine