title: Bone mineralization status measured by dual energy radiographic densitometry in preterm infants fed commercial formulas.
abstract: We have studied the effect of two preterm commercial infant formulas with different calcium and phosphorus contents on the mineral balance and bone mineralization of 30 preterm infants at 1 month of age. Bone mineralization was measured by dual energy X-ray densitometry. The formula supplying a higher content of calcium and phosphorus promoted higher mineral retention (P<0.01) as well as higher bone mineral content (1.556 vs. 1.073 g, P<0.01) and bone mineral density (0.458 vs. 0.424 g/cm2, P<0.05), approaching values of the control group, which comprised a cohort of 15 preterm newborns whose gestational age was 4 weeks older than the subjects selected to be fed with the formulas. The intake of calcium correlated with retention (r=0.69); the phosphorus intake also correlated with phosphorus retention (r=0.95). Intakes of calcium and phosphorus correlated with the bone mineral content (r=0.65) and with bone mineral density (r=0.49). We conclude that formulas for preterm infants should not have a calcium content lower than 120 mg/100 kcal and should have a calcium/phosphorus ratio of about 2 to promote adequate bone mineralization.
authors: Department of Pediatrics, School of Medicine, University of Granada, Spain.
authors: E
authors: E
authors: Narbona
authors: J
authors: J
authors: Maldonado
authors: E
authors: E
authors: Ocete
authors: A
authors: A
authors: Gil
authors: J A
authors: JA
authors: Molina
mesh_terms: D015502:Absorptiometry, Photon; D001827:Body Height; D002113:Calcification, Physiologic; D002118:Calcium / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007225:Infant Food; D007231:Infant, Newborn; D007234:Infant, Premature / Q000254:growth & development; D008297:Male; D010758:Phosphorus / Q000008:administration & dosage; D015430:Weight Gain
chemical_list: D010758:Phosphorus; D002118:Calcium