Effects of cyclosporin A on alveolar bone: an experimental study in the rat.
BACKGROUND
There have been several investigations on the role of cyclosporin A (CSA) in gingival hyperplasia in both animals and humans. However, less attention has been given to the drug's effect on alveolar bone. This study used light microscopy to histologically and histometrically evaluate the effects of CSA on alveolar bone in the rat.


METHODS
Sixty, 6-week-old Sprague-Dawley rats were separated into test and control groups. Animals in the test group received CSA in mineral oil (30 mg/kg body weight) daily by gastric feeding over the 6-week study. Control animals received only mineral oil. Ten animals from each group were sacrificed at weeks 2, 4, and 6. After histologic processing, the labial crest of the alveolar bone in the anterior mandible was evaluated by light microscopy.


RESULTS
A distinct pattern of increased osteoclasia and reduced bone formation was observed in the CSA-exposed animals compared to the controls. Increased osteoclasia was observed in periodontal sites and decreased bone formation was observed in symphyseal sites.


CONCLUSIONS
The results suggest that CSA has distinct effects on alveolar bone.
Fu
E
E
Department of Periodontology, School of Dentistry, National Defense Medical Center and Tri-Service General Hospital, Taipei, Taiwan, ROC.
Hsieh
Y D
YD
Nieh
S
S
Wikesjö
U M
UM
Liu
D
D
D016301:Alveolar Bone Loss / Q000139:chemically induced / Q000473:pathology; D000539:Alveolar Process / Q000187:drug effects* / Q000473:pathology; D000704:Analysis of Variance; D000818:Animals; D001846:Bone Development / Q000187:drug effects; D001857:Bone Matrix / Q000187:drug effects / Q000473:pathology; D002452:Cell Count / Q000187:drug effects; D016572:Cyclosporine / Q000494:pharmacology*; D004195:Disease Models, Animal; D005500:Follow-Up Studies; D005885:Gingival Hyperplasia / Q000139:chemically induced; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008297:Male; D008334:Mandible / Q000187:drug effects / Q000473:pathology; D010011:Osteocytes / Q000187:drug effects / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley
D007166:Immunosuppressive Agents; D016572:Cyclosporine