Strychnine-insensitive glycine/NMDA sites are altered in two stress models of depression.
Chronic severe stress (CSS) and chronic mild stress (CMS) affect the properties of [3H]5,7-dichlorokynurenic acid (5,7-DCKA) binding to strychnine-insensitive glycine/NMDA sites in the rat cerebral cortex. Specifically, CSS decreases, while CMS increases, the potency of glycine to displace [3H]5,7-DCKA binding to glycine/NMDA sites. Moreover, in both models, a reduction of the specific [3H]5,7-DCKA binding was observed. The present results demonstrate the involvement of the cortical NMDA receptor complex in the animal models of depression.
Nowak
G
G
Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Ossowska
G
G
Jopek
R
R
Papp
M
M
D000818:Animals; D001665:Binding Sites; D002540:Cerebral Cortex / Q000378:metabolism; D003863:Depression / Q000503:physiopathology; D018691:Excitatory Amino Acid Antagonists / Q000378:metabolism; D005998:Glycine / Q000378:metabolism*; D007736:Kynurenic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D008297:Male; D008954:Models, Biological; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D013312:Stress, Physiological / Q000378:metabolism*; D013331:Strychnine / Q000494:pharmacology*
D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D007736:Kynurenic Acid; D013331:Strychnine; C066192:5,7-dichlorokynurenic acid; D005998:Glycine