[The use of a method for the quantitative determination of HIV-1 RNA for assessing the severity and prognosis of the development of the disease].
The informatory role of a new marker of HIV infection, characterizing the content of HIV-1 RNA in the biological fluids of the patient's body, is evaluated. The quantitative determination of HIV-1 RNA, carried out in a single assay, was made in the blood of 25 HIV-infected patients. These studies confirmed that the determination of the level of RNA in the plasma (viral load) was a reliable criterion indicating the severity and progress of the disease. The viral load of more than 100,000 copies/ml was a sign prognosticating the future pronounced progress of the disease in spite of moderate clinical manifestations and relatively high values of CD4 cells in the patient's blood at the moment of testing.
Smol'skaia
T T
TT
Pasteur Research Institute of Epidemiology and Microbiology, City Center for Prophylaxis and Control of AIDS, St. Petersburg, Russia.
Sizova
N V
NV
Korovina
G I
GI
Maslov
V P
VP
Kevlova
N A
NA
Novikova
V A
VA
Bogoiavlenskiĭ
G V
GV
D015415:Biomarkers / Q000097:blood; D018450:Disease Progression; D015658:HIV Infections / Q000097:blood* / Q000175:diagnosis; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D011379:Prognosis; D012367:RNA, Viral / Q000097:blood*; D012720:Severity of Illness Index; D019562:Viral Load / Q000379:methods* / Q000706:statistics & numerical data
D015415:Biomarkers; D012367:RNA, Viral