title: Substance dependence and personality disorders: comorbidity and treatment outcome in an inpatient treatment population.
abstract: OBJECTIVE
  Personality disorders (PDs) are common among patients with substance dependence, and antisocial PD in particular has been found to have a significant impact on treatment outcomes. Relatively little is known about other comorbid PDs, however. This study was designed to clarify the distribution of PDs among substance dependent patients and assess their role in treatment outcome.
  
  
  METHODS
  PDs and substance use disorders were diagnosed for 252 (181 male) consecutively admitted substance dependent inpatients using structured clinical interviews. A subsample of these (n = 104) were also followed for 1 year to monitor treatment outcome and relapse.
  
  
  RESULTS
  Fifty percent of the patients were diagnosed with one or more personality disorders, but no consistent relationships between drug of choice and PDs were found. The likelihood of relapse, however, increased significantly with the diagnosis of a PD. Only 6% of the patients who received more than one PD diagnosis were maintaining sobriety at the end of 1 year compared with 44% of those with no PD diagnoses. A preference for cocaine was also a significant predictor of relapse.
  
  
  CONCLUSIONS
  The low participation rate for the treatment outcome study and other methodological limitations render the study results tentative. Nevertheless, the findings suggest that more attention should be given to Axis II disorders in substance dependence research and treatment.
authors: Department of Psychology, Texas Tech University, Lubbock 79409-2051, USA.
authors: V H
authors: VH
authors: Thomas
authors: T P
authors: TP
authors: Melchert
authors: J A
authors: JA
authors: Banken
mesh_terms: D000328:Adult; D016009:Chi-Square Distribution; D015897:Comorbidity; D017831:Diagnosis, Dual (Psychiatry); D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010554:Personality Disorders / Q000145:classification / Q000453:epidemiology*; D015995:Prevalence; D011446:Prospective Studies; D012008:Recurrence; D012114:Residential Treatment; D012737:Sex Factors; D019966:Substance-Related Disorders / Q000453:epidemiology* / Q000628:therapy*; D013695:Temperance; D013781:Texas / Q000453:epidemiology; D016896:Treatment Outcome