Trovafloxacin in combination with vancomycin against penicillin-resistant pneumococci in the rabbit meningitis model.
Trovafloxacin, a new fluoroquinolone, produced bactericidal activity (-0.33 +/- 0.13 delta log10 CFU/ml.h; intravenously [i.v.] administered dose, 15 mg/kg) comparable to that of vancomycin (-0.39 +/- 0.18 delta log10 CFU/ml.h; i.v. admininistered dose, 20 mg/kg) in the treatment of experimental meningitis in rabbits due to a pneumococcal strain highly resistant to penicillin (MIC of penicillin G, 4 micrograms/ml). The combination of both drugs significantly increased (P < 0.05) the killing rate (-0.60 +/- 0.23 delta log10 CFU/ml.h) compared to that produced by either monotherapy. These results were also confirmed in vitro.
Rodoni
D
D
Department of Internal Medicine, Inselspital, Berne, Switzerland.
Hänni
F
F
Gerber
C M
CM
Cottagnoud
M
M
Neftel
K
K
Täuber
M G
MG
Cottagnoud
P
P
D000818:Animals; D000900:Anti-Bacterial Agents / Q000134:cerebrospinal fluid / Q000494:pharmacology / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000134:cerebrospinal fluid / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D024841:Fluoroquinolones; D008586:Meningitis, Pneumococcal / Q000188:drug therapy* / Q000378:metabolism; D009287:Naphthyridines / Q000134:cerebrospinal fluid / Q000494:pharmacology / Q000627:therapeutic use*; D010403:Penicillin Resistance; D011817:Rabbits; D013296:Streptococcus pneumoniae / Q000187:drug effects; D013997:Time Factors; D014640:Vancomycin / Q000134:cerebrospinal fluid / Q000494:pharmacology / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; D014640:Vancomycin; C080163:trovafloxacin