[Trimetazidine effects on exercise tolerance and left ventricular diastolic function in patients with coronary heart disease].
OBJECTIVE
Trial of trimetasidine effects on exercise tolerance (ET) and left ventricular diastolic function (LVDF) in patients with coronary heart disease (CHD).


METHODS
The study group included 40 CHD patients. Of them 10, 18 and 12 had myocardial infarction, unstable angina pectoris and stable angina, respectively. 38 CHD patients of the control group had these disorders, respectively, in 5, 15 and 18 cases. 2-3-month therapy with nitrates, beta-blockers (BB) and inhibitors of angiotensin-converting enzyme (ACE) was given to both groups with adjuvant trimetasidine (60 mg/d) given to patients of the study group. The effects were judged by the results of cycle exercise tests and echo-CG including the loading one.


RESULTS
Adjuvant use of trimetasidine improved exercise tolerance, mean threshold capacity, LVDF. When added to BB treatment, trimetasidine reduced damage to LVDF under dipiridamol test.


CONCLUSIONS
Trimetasidine addition to combined treatment of CHD raises exercise tolerance and improves LVDF.
Kuimov
A D
AD
Maianskaia
S D
SD
Luksha
E B
EB
Volkova
I I
II
Barbarich
V B
VB
Shliakhov
S O
SO
Iakovlev
A V
AV
Poliakova
A M
AM
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D003971:Diastole / Q000187:drug effects; D004176:Dipyridamole; D004359:Drug Therapy, Combination; D004452:Echocardiography; D004562:Electrocardiography; D017079:Exercise Tolerance / Q000187:drug effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000627:therapeutic use; D014292:Trimetazidine / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000627:therapeutic use*; D016277:Ventricular Function, Left / Q000187:drug effects* / Q000502:physiology
D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D009566:Nitrates; D014665:Vasodilator Agents; D004176:Dipyridamole; D014292:Trimetazidine