title: Evidence for an ancient chromosomal duplication in Arabidopsis thaliana by sequencing and analyzing a 400-kb contig at the APETALA2 locus on chromosome 4.
abstract: As part of the European Scientists Sequencing Arabidopsis program, a contiguous region (396607 bp) located on chromosome 4 around the APETALA2 gene was sequenced. Analysis of the sequence and comparison to public databases predicts 103 genes in this area, which represents a gene density of one gene per 3.85 kb. Almost half of the genes show no significant homology to known database entries. In addition, the first 45 kb of the contig, which covers 11 genes, is similar to a region on chromosome 2, as far as coding sequences are concerned. This observation indicates that ancient duplications of large pieces of DNA have occurred in Arabidopsis.
authors: Departement Genetica, Vlaams Interuniversitair Instituut voor Biotechnologie (VIB), Universiteit Gent, Ghent, Belgium.
authors: N
authors: N
authors: Terryn
authors: L
authors: L
authors: Heijnen
authors: A
authors: A
authors: De Keyser
authors: M
authors: M
authors: Van Asseldonck
authors: R
authors: R
authors: De Clercq
authors: H
authors: H
authors: Verbakel
authors: J
authors: J
authors: Gielen
authors: M
authors: M
authors: Zabeau
authors: R
authors: R
authors: Villarroel
authors: T
authors: T
authors: Jesse
authors: P
authors: P
authors: Neyt
authors: R
authors: R
authors: Hogers
authors: H
authors: H
authors: Van Den Daele
authors: W
authors: W
authors: Ardiles
authors: C
authors: C
authors: Schueller
authors: K
authors: K
authors: Mayer
authors: P
authors: P
authors: Déhais
authors: S
authors: S
authors: Rombauts
authors: M
authors: M
authors: Van Montagu
authors: P
authors: P
authors: Rouzé
authors: P
authors: P
authors: Vos
mesh_terms: D017360:Arabidopsis / Q000235:genetics; D029681:Arabidopsis Proteins; D001483:Base Sequence; D002874:Chromosome Mapping; D020451:Contig Mapping; D018744:DNA, Plant; D020440:Gene Duplication; D017343:Genes, Plant; D018745:Genome, Plant; D018398:Homeodomain Proteins / Q000235:genetics*; D007438:Introns; D008432:Mathematical Computing; D008969:Molecular Sequence Data; D005810:Multigene Family; D009687:Nuclear Proteins / Q000235:genetics*; D010940:Plant Proteins / Q000235:genetics*
chemical_list: C499534:APETALA2 protein, Arabidopsis; D029681:Arabidopsis Proteins; D018744:DNA, Plant; D018398:Homeodomain Proteins; D009687:Nuclear Proteins; D010940:Plant Proteins