title: Subfertile men with constitutive chromosome abnormalities do not necessarily refrain from intracytoplasmic sperm injection treatment: a follow-up study on 75 Dutch patients.
abstract: A follow-up study was performed to investigate the impact of the detection of a chromosome abnormality in infertile men who are candidates for intracytoplasmic sperm injection (ICSI) treatment. In this collaborative study between clinical genetics centres and fertility clinics in the Netherlands, 75 ICSI couples of which the male partners had a chromosome abnormality were included. All couples were extensively counselled on the risk of having a chromosomally unbalanced child. Forty-two out of 75 couples chose to proceed with the ICSI treatment. So far, treatment has resulted in a pregnancy in 11 cases. Four of them opted to have invasive prenatal diagnosis. Despite the genetic risks related to a chromosome abnormality in infertile men, a small majority (56%) of the couples did not refrain from the ICSI treatment.
authors: Clinical Genetics Center, Utrecht, The Netherlands.
authors: J C
authors: JC
authors: Giltay
authors: P M
authors: PM
authors: Kastrop
authors: J H
authors: JH
authors: Tuerlings
authors: J A
authors: JA
authors: Kremer
authors: C H
authors: CH
authors: Tiemessen
authors: K B
authors: KB
authors: Gerssen-Schoorl
authors: F
authors: F
authors: van der Veen
authors: J
authors: J
authors: de Vries
authors: R
authors: R
authors: Hordijk
authors: G J
authors: GJ
authors: Hamers
authors: K
authors: K
authors: Hansson
authors: M
authors: M
authors: van der Blij-Philipsen
authors: L C
authors: LC
authors: Govaerts
authors: M H
authors: MH
authors: Pieters
authors: K
authors: K
authors: Madan
authors: J M
authors: JM
authors: Scheres
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations / Q000175:diagnosis / Q000503:physiopathology; D025063:Chromosome Disorders; D003593:Cytoplasm / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D007621:Karyotyping; D008297:Male; D008846:Micromanipulation; D011247:Pregnancy; D018873:Pregnancy Rate; D011296:Prenatal Diagnosis; D012016:Reference Values; D013094:Spermatozoa / Q000502:physiology*