title: The maternal, fetal and postnatal somatotrophic axes in intrauterine growth retardation.
abstract: Both the maternal and fetal somatotrophic axes are closely linked to fetal substrate supply. Nutritional insults at critical stages of fetal development may lead to permanent reprogramming of the relationships between these factors. The consequences of reprogramming during fetal life may be harmful to metabolic, endocrine and cardiovascular homoeostatic mechanisms in postnatal life. The exact mechanisms that lead to reprogramming during fetal life need thorough investigation before effective strategies to deal with this problem can be devised.
authors: Research Centre for Developmental Medicine and Biology, University of Auckland, New Zealand.
authors: M H
authors: MH
authors: Oliver
authors: F H
authors: FH
authors: Bloomfield
authors: J E
authors: JE
authors: Harding
authors: B H
authors: BH
authors: Breier
authors: N S
authors: NS
authors: Bassett
authors: P D
authors: PD
authors: Gluckman
mesh_terms: D000653:Amniotic Fluid / Q000502:physiology; D000818:Animals; D005314:Embryonic and Fetal Development / Q000502:physiology; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology* / Q000503:physiopathology*; D006133:Growth Substances / Q000502:physiology; D019382:Human Growth Hormone / Q000502:physiology*; D006801:Humans; D007231:Infant, Newborn; D007333:Insulin Resistance / Q000502:physiology; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D009747:Nutritional Physiological Phenomena; D011247:Pregnancy
chemical_list: D006133:Growth Substances; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I