title: Xenopus brain factor-2 controls mesoderm, forebrain and neural crest development.
abstract: The forkhead type Brain Factor 2 from mouse and chicken help pattern the forebrain, optic vesicle and kidney. We have isolated a Xenopus homolog (Xbf2) and found that during gastrulation it is expressed in the dorsolateral mesoderm, where it helps specify this territory by downregulating BMP-4 and its downstream genes. Indeed, Xbf2 overexpression caused partial axis duplication. Interference with BMP-4 signaling also occurs in isolated animal caps, since Xbf2 induces neural tissue. Within the neurula forebrain, Xbf2 and the related Xbf1 gene are expressed in the contiguous diencephalic and telencephalic territories, respectively, and each gene represses the other. Finally, Xbf2 seems to participate in the control of neural crest migration. Our data suggest that XBF2 interferes with BMP-4 signaling, both in mesoderm and ectoderm.
authors: Laboratorio de Biología del Desarrollo, Facultad de Ciencias, Universidad de Chile, Santiago, Chile.
authors: J L
authors: JL
authors: Gómez-Skarmeta
authors: E
authors: E
authors: de la Calle-Mustienes
authors: J
authors: J
authors: Modolell
authors: R
authors: R
authors: Mayor
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins / Q000378:metabolism / Q000502:physiology*; D004627:Embryonic Induction; D051858:Forkhead Transcription Factors; D005697:Galactosides / Q000378:metabolism; D015870:Gene Expression; D017403:In Situ Hybridization; D007211:Indoles / Q000378:metabolism; D008648:Mesoderm / Q000502:physiology*; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000502:physiology*; D009432:Neural Crest / Q000502:physiology*; D016548:Prosencephalon / Q000196:embryology*; D013997:Time Factors; D051879:Twist-Related Protein 1; D014981:Xenopus / Q000196:embryology* / Q000378:metabolism*; D029867:Xenopus Proteins
chemical_list: D004268:DNA-Binding Proteins; D051858:Forkhead Transcription Factors; C489562:Foxd1 protein, mouse; D005697:Galactosides; D007211:Indoles; D009419:Nerve Tissue Proteins; D051879:Twist-Related Protein 1; D029867:Xenopus Proteins; C581761:twist basic helix-loop-helix transcription factor 1, Xenopus; C044888:5-bromo-4-chloro-3-indolyl beta-galactoside