Utilizing routine sonohysterography to detect intrauterine pathology before initiating hormone replacement therapy.
OBJECTIVE
To assess the utility of performing routine sonohysterography in conjunction with endometrial thickness measurement for detecting intrauterine pathology in asymptomatic postmenopausal women.


METHODS
Asymptomatic postmenopausal women (n = 60, mean age 52.7 +/- 4.5 years, amenorrhea > or = 6 months, follicle stimulating hormone > or = 40 mIU/mL) were evaluated with sonohysterography followed by endometrial biopsy before initiating hormone replacement therapy.


RESULTS
Hyperplasia was detected in 5 of 22 (22.7%) patients with endometrial thickness of > 5 mm and in 0 of 38 (0.0%) patients with endometrial thickness of < or = 5 mm. When sonohysterography was performed, intracavitary pathology was discovered in 14 of 38 (36.8%) patients with endometrial thickness of < or = 5 mm (10 polyps, three submucosal myomas, and one septate uterus) and 14 of 22 (63.6%) patients with endometrial thickness of > 5 mm (nine polyps, four submucosal myomas, and one Asherman's syndrome).


CONCLUSIONS
Endometrial thickness of < or = 5 mm excludes hyperplasia but does not eliminate other intrauterine pathology that may be discovered by sonohysterography.
Cohen
M A
MA
Department of Obstetrics and Gynecology, Columbia Presbyterian Medical Center, New York, New York 10032, USA.
Sauer
M V
MV
Keltz
M
M
Lindheim
S R
SR
D000368:Aged; D001707:Biopsy, Needle; D004717:Endometrium / Q000000981:diagnostic imaging / Q000473:pathology*; D019160:Endosonography / Q000706:statistics & numerical data*; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause / Q000502:physiology; D011237:Predictive Value of Tests; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D013997:Time Factors; D014591:Uterine Diseases / Q000000981:diagnostic imaging* / Q000473:pathology*