Indinavir-induced nephropathy.
We report the case of a 38-year-old male who developed renal insufficiency while on the protease inhibitor, indinavir. This patient had an increase in serum creatinine over a period of approximately one year, along with persistently abnormal urinalysis. A renal biopsy was performed and showed marked tubular crystal deposition. The indinavir was discontinued, and after two months the patient's serum creatinine and urinalysis returned to normal. To our knowledge this is the second case of indinavir associated nephropathy.
Grabe
D W
DW
Albany College of Pharmacy, N.Y., USA.
Eisele
G
G
Miller
C
C
Singh
J
J
Stein
D
D
D000328:Adult; D001706:Biopsy; D017321:Clinical Trials, Phase I as Topic; D003404:Creatinine / Q000097:blood; D015658:HIV Infections / Q000188:drug therapy; D017320:HIV Protease Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D019469:Indinavir / Q000009:adverse effects* / Q000627:therapeutic use; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D051437:Renal Insufficiency / Q000139:chemically induced* / Q000473:pathology
D017320:HIV Protease Inhibitors; D019469:Indinavir; D003404:Creatinine