title: Neuroinvasion by human herpesvirus type 7 in a case of exanthem subitum with severe neurologic manifestations.
abstract: A 19-month-old girl presented with severe neurologic symptoms associated with exanthem subitum. Human herpesvirus type 7 (HHV-7) DNA was detected in the CSF and serum, and supported by serologic studies. The patient was diagnosed with encephalopathy due to an acute HHV-7 infection. Neuron-specific enolase in the CSF was strongly elevated during the acute stage of infection, suggesting that the encephalopathy was due to viral invasion of the brain.
authors: Department of Child Neurology, University Hospital Nijmegen, The Netherlands.
authors: J S
authors: JS
authors: van den Berg
authors: J H
authors: JH
authors: van Zeijl
authors: J J
authors: JJ
authors: Rotteveel
authors: W J
authors: WJ
authors: Melchers
authors: F J
authors: FJ
authors: Gabreëls
authors: J M
authors: JM
authors: Galama
mesh_terms: D001927:Brain Diseases / Q000209:etiology / Q000821:virology*; D004279:DNA, Viral / Q000134:cerebrospinal fluid; D005260:Female; D006566:Herpesviridae Infections / Q000134:cerebrospinal fluid* / Q000150:complications; D016199:Herpesvirus 7, Human; D006801:Humans; D007223:Infant; D010751:Phosphopyruvate Hydratase / Q000134:cerebrospinal fluid; D016133:Polymerase Chain Reaction
chemical_list: D004279:DNA, Viral; D010751:Phosphopyruvate Hydratase