Truncated growth hormone receptor isoforms.
Truncated forms of the growth hormone receptor (GHR) that lack the majority of the cytoplasmic domain have been identified in a number of human tissues. In vitro, these truncated receptors act as dominant-negative inhibitors of the growth hormone (GH) signal and also generate large amounts of growth hormone binding protein (GHBP). Mutations that lead to high levels of expression of the truncated GHR are associated with short stature and GH insensitivity. Thus, truncated GHRs may be important as a physiological regulator of GH signalling in addition to providing a mechanism for the production of GHBP.
Ross
R J
RJ
Division of Clinical Sciences, University of Sheffield, Northern General Hospital, UK.
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics*; D046508:Culture Techniques; D006801:Humans; D008103:Liver Cirrhosis / Q000235:genetics; D009154:Mutation / Q000235:genetics*; D016133:Polymerase Chain Reaction; D020033:Protein Isoforms / Q000235:genetics; D011986:Receptors, Somatotropin / Q000235:genetics*; D013045:Species Specificity
D002352:Carrier Proteins; D020033:Protein Isoforms; D011986:Receptors, Somatotropin; C051815:somatotropin-binding protein