title: Inhibition of herpes proteases and antiviral activity of 2-substituted thieno[2,3-d]oxazinones.
abstract: Cinnamyl derivatives of thieno[2,3-d]oxazinones are mechanism-based inhibitors of the HSV-2, VZV and CMV herpes proteases which demonstrate nanomolar potency. Compounds 5 and 28 inhibit protease processing in HSV-2 infected cells with a selectivity index of at least 30.
authors: SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Harlow, Essex, UK. Richard_L_Jarvest@sbphrd.com
authors: R L
authors: RL
authors: Jarvest
authors: I L
authors: IL
authors: Pinto
authors: S M
authors: SM
authors: Ashman
authors: C E
authors: CE
authors: Dabrowski
authors: A V
authors: AV
authors: Fernandez
authors: L J
authors: LJ
authors: Jennings
authors: P
authors: P
authors: Lavery
authors: D G
authors: DG
authors: Tew
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D006564:Herpesviridae / Q000201:enzymology*; D010078:Oxazines / Q000737:chemistry / Q000494:pharmacology*; D011480:Protease Inhibitors / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D010078:Oxazines; D011480:Protease Inhibitors