Synthesis and biological evaluation of 1alpha,24-dihydroxy-25-nitrovitamin D3.
1Alpha,24(R)Dihydroxy-25-nitrovitamin D3 1 and 1alpha,24(S)-dihydroxy-25-nitrovitamin D3 2 were synthesized using the palladium-catalyzed alkylative enyne cyclization reaction. Their biological properties were studied based on VDR binding affinity and HL-60 cell differentiation activity.
Oshida
J
J
Iwakuni Pharmaceutical Factory, Teijin, Ltd., Iwakuni, Yamaguchi, Japan.
Okamoto
M
M
Ishizuka
S
S
Azuma
S
S
D000818:Animals; D002117:Calcitriol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects; D002645:Chickens; D018922:HL-60 Cells; D006801:Humans; D009574:Nitro Compounds / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D010165:Palladium / Q000737:chemistry; D011485:Protein Binding; D018167:Receptors, Calcitriol / Q000378:metabolism
C118930:1,24-dihydroxy-25-nitrovitamin D3; D009574:Nitro Compounds; D018167:Receptors, Calcitriol; D010165:Palladium; D002117:Calcitriol