title: Meiotic abnormalities and spermatogenic parameters in severe oligoasthenozoospermia.
abstract: The incidence of meiotic abnormalities and their relationship with different spermatogenic parameters was assessed in 103 male patients with presumably idiopathic severe oligoasthenozoospermia (motile sperm concentration < or = 1.5 x 10(6)/ml). Meiosis on testicular biopsies was independently evaluated by two observers. Meiotic patterns included normal meiosis and two meiotic abnormalities, i.e. severe arrest and synaptic anomalies. A normal pattern was found in 64 (62.1%), severe arrest in 21 (20.4%) and synaptic anomalies in 18 (17.5%). The overall rate of meiotic abnormalities was 37.9%. Most (66.7%) meiotic abnormalities occurred in patients with a sperm concentration < or = 1 x 10(6)/ml. In this group, total meiotic abnormalities were found in 57.8% of the patients; of these, 26.7% had synaptic anomalies. When the sperm concentration was < or = 0.5 x 10(6)/ml, synaptic anomalies were detected in 40% of the patients. In patients with increased follicle stimulating hormone (FSH) concentrations, total meiotic abnormalities occurred in 54.8% (synaptic anomalies in 22.6%). There were statistically significant differences among the three meiotic patterns in relation to sperm concentration (P < 0.001) and serum FSH concentration (P < 0.05). In the multivariate analysis, sperm concentration < or = 1 x 10(6)/ml and/or FSH concentration > 10 IU/l were the only predictors of meiotic abnormalities.
authors: Department of Obstetrics and Gynaecology, Institut Universitari Dexeus, Universitat Autònoma de Barcelona, Spain.
authors: J M
authors: JM
authors: Vendrell
authors: F
authors: F
authors: García
authors: A
authors: A
authors: Veiga
authors: G
authors: G
authors: Calderón
authors: S
authors: S
authors: Egozcue
authors: J
authors: J
authors: Egozcue
authors: P N
authors: PN
authors: Barri
mesh_terms: D000328:Adult; D001706:Biopsy; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007621:Karyotyping; D008297:Male; D008540:Meiosis / Q000502:physiology*; D009845:Oligospermia / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology*; D011237:Predictive Value of Tests; D013076:Sperm Count; D013091:Spermatogenesis / Q000502:physiology*; D013569:Synapses / Q000502:physiology; D013737:Testis / Q000473:pathology
chemical_list: D005640:Follicle Stimulating Hormone