title: Pharmacokinetics of oral zidovudine entrapped in biodegradable nanospheres in rabbits.
abstract: The pharmacokinetic profile of oral zidovudine entrapped in a 50:50 polyactide-coglycolide matrix (nanospheres) was compared to those of standard oral and parenteral zidovudine formulations in rabbits. The bioavailability of zidovudine nanospheres at 50 mg/kg of body weight was 76%, and this dose achieved prolonged exposure to zidovudine compared to standard formulations without an increase in the drug's peak concentration.
authors: Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA.
authors: D P
authors: DP
authors: Callender
authors: N
authors: N
authors: Jayaprakash
authors: A
authors: A
authors: Bell
authors: V
authors: V
authors: Petraitis
authors: R
authors: R
authors: Petraitiene
authors: M
authors: M
authors: Candelario
authors: R
authors: R
authors: Schaufele
authors: J M
authors: JM
authors: Dunn
authors: S
authors: S
authors: Sei
authors: T J
authors: TJ
authors: Walsh
authors: F M
authors: FM
authors: Balis
authors: R
authors: R
authors: Petratienes
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D019540:Area Under Curve; D001673:Biodegradation, Environmental; D001835:Body Weight; D004337:Drug Carriers; D008863:Microspheres; D011817:Rabbits; D015215:Zidovudine / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D019380:Anti-HIV Agents; D004337:Drug Carriers; D015215:Zidovudine