[The successes and problems in the treatment of HIV infection: a biochemist's view].
The problems of the effectiveness of the treatment of HIV-infected patients with 11 medicinal preparations and their combinations are discussed. 5 preparations (AZT, zalcitabine, videx, stavudine and lamivudine) are the nucleoside inhibitors of the synthesis of provirus DNA, catalyzed by inverse transcriptases; 2 preparations (nevirapine and rescriptor) are the inhibitors of this enzyme, having nonnucleoside nature, and 4 preparations (saquinarin, ritonavir, indinavir and nelfinavir) are the inhibitors of the processing of virus RNA, catalyzed by HIV protease. The modern concepts of the mechanism of action of the above-mentioned preparations are presented and the problem of the search of new effective medicinal preparations is discussed.
Kraevskiĭ
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AA
Engelhardt Institute of Molecular Biology, Moscow, Russia.
D019380:Anti-HIV Agents / Q000037:antagonists & inhibitors / Q000627:therapeutic use; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000037:antagonists & inhibitors / Q000627:therapeutic use; D015497:HIV-1; D006801:Humans; D012074:Remission Induction; D017211:Treatment Failure
D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors