title: Positive margins of breast biopsy: is reexcision always necessary?
abstract: OBJECTIVE
  Breast-conserving surgery requires excision of all gross tumor and subsequent radiation therapy. It is generally accepted that the presence of microscopically positive margins requires reexcision. The goal of this study was to identify characteristics that distinguish breast biopsy specimens with positive margins that when reexcised are free from residual tumor. This population of patients may benefit from breast irradiation only, without the need for another surgical procedure.
  
  
  METHODS
  One hundred and fifteen of 395 cancer-proven biopsies had positive surgical margins and were treated with reexcision or mastectomy. Sixty-seven of these were negative for residual tumor and 48 were positive for residual tumor. Evaluation for tumor type, tumor size, grade, presence of vascular invasion, volume of the biopsy specimen, true positivity and the number of positive margins, multifocality of the tumor, and type of anesthesia was done by univariate and multivariate analysis.
  
  
  RESULTS
  Univariate and multivariate analysis revealed that factors associated with a positive reexcision included margin status, method of detection, histologic appearance, and type of anesthesia used.
  
  
  CONCLUSIONS
  These results suggest that small, clinically detectable unifocal tumors could be treated without the need for a further excision. Eradication of microscopic residual tumor could be done by irradiation only, sparing the patient an additional surgical procedure.
authors: Department of Surgery and Surgical Oncology, Chaim Sheba Medical Center, Tel Aviv University Sackler Medical School, Tel Hashomer, Israel.
authors: M Z
authors: MZ
authors: Papa
authors: D
authors: D
authors: Zippel
authors: M
authors: M
authors: Koller
authors: E
authors: E
authors: Klein
authors: A
authors: A
authors: Chetrit
authors: G B
authors: GB
authors: Ari
mesh_terms: D000368:Aged; D001706:Biopsy; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D012086:Reoperation