An in vitro study on the toxic effects of nonylphenols (NP) in mitochondria.
This paper is focused on alkylphenols, compounds which are formed by the biodegradation of polyethoxilatedalkylphenols detergents. Our experiments show that alkylphenols act not only as detergents, but also as uncouplers of the oxidative phosphorylation. This effect, can be observed at very low doses, thus suggesting that the preferential target of nonylphenols in living organisms are mitochondria.
Bragadin
M
M
Dipartimento di Scienze Ambientali, Università di Venezia, Italy. aleiero@unive.it
Perin
G
G
Iero
A
A
Manente
S
S
Rizzoli
V
V
Scutari
G
G
D000818:Animals; D001673:Biodegradation, Environmental; D003902:Detergents / Q000493:pharmacokinetics / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D010636:Phenols / Q000493:pharmacokinetics / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D014475:Uncoupling Agents / Q000378:metabolism
D003902:Detergents; D010636:Phenols; D014475:Uncoupling Agents