Cobalt proteins.
In the form of vitamin B12, cobalt plays a number of crucial roles in many biological functions. However, recent studies have provided information on the biochemistry and bioinorganic chemistry of several proteins containing cobalt in a form other than that in the corrin ring of vitamin B12. To date, eight noncorrin-cobalt-containing enzymes (methionine aminopeptidase, prolidase, nitrile hydratase, glucose isomerase, methylmalonyl-CoA carboxytransferase, aldehyde decarbonylase, lysine-2,3-aminomutase, and bromoperoxidase) have been isolated and characterized. A cobalt transporter is involved in the metallocenter biosynthesis of the host cobalt-containing enzyme, nitrile hydratase. Understanding the differences between cobalt and nickel transporters might lead to drug development for gastritis and peptic ulceration.
Kobayashi
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M
Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Japan.
Shimizu
S
S
D019747:Aldose-Ketose Isomerases / Q000737:chemistry; D000595:Amino Acid Sequence; D000626:Aminopeptidases / Q000737:chemistry; D000818:Animals; D001426:Bacterial Proteins; D001665:Binding Sites / Q000235:genetics; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics; D027682:Cation Transport Proteins; D003035:Cobalt / Q000737:chemistry*; D004150:Dipeptidases / Q000737:chemistry; D004926:Escherichia coli / Q000201:enzymology; D006801:Humans; D006836:Hydro-Lyases / Q000737:chemistry / Q000235:genetics; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics; D063208:Methionyl Aminopeptidases; D008958:Models, Molecular; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry*; D017386:Sequence Homology, Amino Acid
D001426:Bacterial Proteins; D002352:Carrier Proteins; D027682:Cation Transport Proteins; D008565:Membrane Proteins; C103702:NhlF protein, Rhodococcus rhodochrous; D011506:Proteins; D003035:Cobalt; D000626:Aminopeptidases; D063208:Methionyl Aminopeptidases; D004150:Dipeptidases; C022449:proline dipeptidase; D006836:Hydro-Lyases; C048831:nitrile hydratase; D019747:Aldose-Ketose Isomerases; C023298:xylose isomerase