Effect of thyroxine on the contractile responses of the vas deferens to prostaglandin E2.
The effects of prostaglandin E2 (PGE2) on the contractile activity of thyroidectomized and thyroxine-treated albino rats were studied in vitro. Thyroidectomy totally inhibited the contractile response of the vas deferens to PGE2. Thyroxine treatment, on the other hand, significantly (P < .001) potentiated the response of vasa deferentia to PGE2, when compared to controls. It is suggested that thyroid hormones play a role in the contractile response of the vas deferens to PGE2.
Amadi
K
K
Department of Human Physiology, Faculty of Medical Sciences, University of Jos, Nigeria.
Nwana
E J
EJ
Otubu
J A
JA
D000818:Animals; D015232:Dinoprostone / Q000378:metabolism* / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013974:Thyroxine / Q000378:metabolism* / Q000494:pharmacology; D014649:Vas Deferens / Q000187:drug effects / Q000502:physiology*
D015232:Dinoprostone; D013974:Thyroxine