Identification of the major urinary and fecal metabolites of 3,5-dinitrobenzamide in chickens and rats.
Colostomized chickens given oral doses of 3,5-dinitrobenzamide (nitromide) cleared nitromide predominantly through the urine (58% of dose) and feces (21% of dose). Rats cleared 52% of nitromide via urinary excretion and 44% via feces. Major urinary metabolites for both chickens and rats include: 3-amino-5-nitrobenzamide, 3-acetamido-5-nitrobenzamide, 3-acetamide-5-aminobenzamide, and 3,5-diacetamidobenzamide. The major fecal metabolite in chickens was 3-acetamido-5-nitrobenzamide (67% of fecal 14C) and 3-acetamido-5-aminobenzamide in rats (approximately 50%).
Shappell
N W
NW
U.S. Department of Agriculture, Agricultural Research Service, Biosciences Research Laboratory, Fargo, ND 58105, USA.
Larsen
G L
GL
Bakke
J E
JE
D000284:Administration, Oral; D000821:Animal Feed; D000818:Animals; D000981:Antiprotozoal Agents / Q000378:metabolism / Q000493:pharmacokinetics* / Q000652:urine; D001549:Benzamides / Q000378:metabolism / Q000493:pharmacokinetics* / Q000652:urine; D002645:Chickens; D003125:Colostomy / Q000662:veterinary; D005243:Feces / Q000737:chemistry; D005503:Food Additives; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D000981:Antiprotozoal Agents; D001549:Benzamides; D005503:Food Additives; C008599:nitromide