Modulation of multidrug resistance in tumor cells by taxinine derivatives.
Among a series of taxinine (1) and its designed derivatives (2-33), two taxoids (29 and 33) increased cellular accumulation of vincristine in multidrug-resistant tumor cells more potently than verapamil, while the activities of eight taxoids (11, 14-16, 22, and 30-32) were comparable with that of verapamil. These results reveal that some taxinine derivatives are good modifiers of multidrug resistance in tumor cells.
Hosoyama
H
H
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Shigemori
H
H
Tomida
A
A
Tsuruo
T
T
Kobayashi
J
J
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000493:pharmacokinetics; D001952:Bridged-Ring Compounds / Q000737:chemistry / Q000494:pharmacology*; D018432:Drug Resistance, Multiple; D004357:Drug Synergism; D006801:Humans; D051379:Mice; D014407:Tumor Cells, Cultured; D014750:Vincristine / Q000493:pharmacokinetics
D000972:Antineoplastic Agents, Phytogenic; D001952:Bridged-Ring Compounds; D014750:Vincristine