title: [Interstitial lung disease induced by timolol eye solution].
abstract: Timolol maleate is a beta-blocker widely used in topical administration for open angle glaucoma. We report a case of interstitial pneumopathy which developed in a 58-year-old patient who was given timolol eyedrops (2 drops b.i.d. since 1986). The patient presented with cough and dyspnea and was found to have a restrictive disorder leading to hypoxemia (68 mmHg at rest and 51 mmHg during exercise). Bronchial lavage fluid had high lymphocyte (28%) and neutrophil (7%) counts. Transbronchial biopsies demonstrated moderate fibrous thickening of the interalveolar walls. Timolol eyedrops were stopped. Three months later, the patient was asymptomatic with normal lung function, chest x-ray and thoracic CT-scan.
authors: Service de Pneumologie et Immunoallergologie, Hôpital Calmette, CHU, Lille.
authors: L M
authors: LM
authors: Vandezande
authors: K
authors: K
authors: Gallouj
authors: C
authors: C
authors: Lamblin
authors: B
authors: B
authors: Fourquet
authors: E
authors: E
authors: Maillot
authors: B
authors: B
authors: Wallaert
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000009:adverse effects*; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D013999:Timolol / Q000009:adverse effects*
chemical_list: D000319:Adrenergic beta-Antagonists; D009883:Ophthalmic Solutions; D013999:Timolol