An overlap syndrome with features of atypical Cogan syndrome and Wegener's granulomatosis.
A 48 year old women developed serous otitis, scleritis, myalgia, vertigo, polyneuropathy, crescentic glomerulonephritis, general cerebral dysrythmia, hilar adenopathy, and retroorbital granulomatous inflammation. Pulmonary manifestations were absent and antibodies against neutrophilic cytoplasmic antigens (ANCA) could not be detected. The clinical picture was classified as an overlap syndrome with features of both atypical Cogan syndrome and Wegener's granulomatosis. The patient responded to treatment with high dose corticosteroids and pulse cyclophosphamide.
Gran
J T
JT
Department of Rheumatology, University Hospital of Tromsø, Norway.
Nordvåg
B Y
BY
Storesund
B
B
D003520:Cyclophosphamide / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D003639:Hearing Loss, Sudden / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D015423:Scleritis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D013577:Syndrome; D016896:Treatment Outcome
D005938:Glucocorticoids; D003520:Cyclophosphamide