Endometrial evaluation is not predictive for in vitro fertilization treatment.
OBJECTIVE
The main purpose of this study was to evaluate ovarian function by clomiphene citrate (CC) challenge test in a group of tubal infertile women and to study endometrial morphological maturation in the early luteal phase of CC-stimulated cycles as compared to in vitro fertilization (IVF) treatment outcome.


RESULTS
Four women presented with strongly retarded, proliferative endometrium in the luteal phase. Of these, three presented with impaired ovarian function, high basal follicle-stimulating hormone, and high follicle-stimulating hormone levels after clomiphene stimulation on cycle day 10. In the remaining 30 women, showing an in-phase endometrium after CC stimulation, a comparison of six morphological characteristics did not reveal any significant differences between the 14 women who did become pregnant and the 16 who did not. No significant differences in endometrial thickness were observed between the groups. Significant differences were found when comparing estradiol and progesterone area under the curve during the luteal phase (P < 0.001 and P < 0.01, respectively) between those who did and those who did not become pregnant.


CONCLUSIONS
Luteal endometrium morphology was not a sharp instrument to detect differences between women who did and women who did not become pregnant following IVF treatment, while ovarian function, as measured by hormonal markers, seemed to be a more reliable prognostic factor for IVF treatment outcome.
Csemiczky
G
G
Department of Woman and Child Health, Karolinska Hospital, Stockholm, Sweden.
Wramsby
H
H
Johannisson
E
E
Landgren
B M
BM
D019540:Area Under Curve; D002996:Clomiphene; D004717:Endometrium / Q000502:physiology*; D004958:Estradiol / Q000097:blood; D005260:Female; D005300:Fertility Agents, Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007118:Immunoassay; D007247:Infertility, Female / Q000503:physiopathology*; D008163:Luminescent Measurements; D008183:Luteal Phase / Q000502:physiology; D007986:Luteinizing Hormone / Q000097:blood / Q000652:urine; D008297:Male; D010053:Ovary / Q000503:physiopathology*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D016896:Treatment Outcome
D005300:Fertility Agents, Female; D002996:Clomiphene; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone