Sickle cell-like crisis and bone marrow necrosis associated with parvovirus B19 infection and heterozygosity for haemoglobins S and E.
In the literature, heterozygosity for haemoglobins S and E is known as a clinically benign condition. Nevertheless, we present a case of double heterozygosity manifesting as an infarctive sickle cell-like crisis with acute chest syndrome and reversible bone marrow necrosis. Importantly, these complications were associated with serologically documented parvovirus B19 infection. Reviewing the literature, this case emphasizes a specific role of parvovirus B19 as a precipitating cause. Furthermore, it demonstrates how important the consideration of haemoglobin disorders can be even outside of the historically known areas.
Eichhorn
R F
RF
Department of Medicine, Westeinde Hospital, The Hague, The Netherlands.
Buurke
E J
EJ
Blok
P
P
Berends
M J
MJ
Jansen
C L
CL
D000328:Adult; D000755:Anemia, Sickle Cell / Q000209:etiology* / Q000235:genetics / Q000821:virology; D001853:Bone Marrow / Q000473:pathology* / Q000821:virology; D005260:Female; D006446:Hemoglobin E / Q000235:genetics*; D006451:Hemoglobin, Sickle / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D009336:Necrosis; D010322:Parvoviridae Infections / Q000150:complications*; D016732:Parvovirus B19, Human
D006451:Hemoglobin, Sickle; D006446:Hemoglobin E