[A recombinant HIV-1 strain causing an epidemic among injection drug addicts in Kaliningrad].
The analysis of the genetic structure of HIV causing the epidemic in Kaliningrad Province. A new recombinant virus of subtype A/B was detected with the use of the polymerase chain reaction, the cloning of amplified fragments, sequencing and the phylogenetic analysis of the obtained data. The results thus obtained indicate that the epidemic in Kaliningrad was caused by a recombinant strain, and not due to co-infection caused by two HIV strains of different subtypes. The study of HIV-1 DNA revealed the divergence between the samples was extremely low, which was characteristic of epidemics connected with the transmission of the virus in the process of the intravenous use of narcotic drugs.
Korovina
G I
GI
North-West Regional Center for Prophylaxis and Control of AIDS, Pasteur Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia.
Smol'skaia
T T
TT
Tashkinova
I P
IP
Momot
O F
OF
Kevlova
N A
NA
Liitsola
K
K
Leinikki
P
P
Salminen
M
M
D001483:Base Sequence; D004196:Disease Outbreaks; D016679:Genome, Viral; D015658:HIV Infections / Q000453:epidemiology / Q000821:virology*; D015497:HIV-1 / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D006801:Humans; D008097:Lithuania; D009293:Opioid-Related Disorders / Q000821:virology*; D010802:Phylogeny; D016865:Reassortant Viruses / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D012426:Russia / Q000453:epidemiology; D015819:Substance Abuse, Intravenous / Q000821:virology*; D014455:Ukraine