Possible mechanisms underlying the cholesterol-raising effect of the coffee diterpene cafestol.
Cafestol, a coffee diterpene present in unfiltered coffee brews, potently raises serum lipids in humans. The mechanism through which this dietary compound influences liporotein metabolism is largely unknown. Unravelling the mechanism of action might lead to new insights into the regulation of serum cholesterol levels in humans. This review summaries ways in which cafestol may act on serum lipids.
de Roos
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Division of Human Nutrition and Epidemiology, Wageningen Centre for Food Sciences, The Netherlands.
Katan
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MB
D022762:CCAAT-Enhancer-Binding Proteins; D002352:Carrier Proteins / Q000378:metabolism; D002784:Cholesterol / Q000097:blood*; D053480:Cholesterol Ester Transfer Proteins; D003069:Coffee / Q000737:chemistry*; D004268:DNA-Binding Proteins / Q000378:metabolism; D004224:Diterpenes / Q000494:pharmacology*; D006023:Glycoproteins; D006801:Humans; D009687:Nuclear Proteins / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D051780:Sterol Regulatory Element Binding Protein 1; D014157:Transcription Factors / Q000378:metabolism
D022762:CCAAT-Enhancer-Binding Proteins; C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D003069:Coffee; D004268:DNA-Binding Proteins; D004224:Diterpenes; D006023:Glycoproteins; D009687:Nuclear Proteins; D018160:Receptors, Cytoplasmic and Nuclear; C497387:SREBF1 protein, human; D051780:Sterol Regulatory Element Binding Protein 1; D014157:Transcription Factors; D002784:Cholesterol; C053400:cafestol