Cytologic features of secretory meningioma.
OBJECTIVE
To describe the cytologic features of secretory meningioma on crush preparations.


METHODS
In five cases, the diagnosis of secretory meningioma was made and crush preparations were available. In each case, crush preparations were made at the time of intraoperative consultation from an open biopsy specimen or stereotactic biopsy.


RESULTS
Hematoxylin and eosin-stained crushes showed the presence of clusters of cohesive cells containing variable numbers of inclusions among less cohesive typical meningothelial cells. In two cases, the inclusions were especially prominent. Inclusions varied in size from 3 to 40 microns, had a well-defined rim and contained finely granular or hyaline material and a central core.


CONCLUSIONS
Secretory meningiomas demonstrate distinct cytologic features on crush preparations. Recognition of these inclusions is important since their prominence in some stereotactic smear preparations may lead to diagnostic problems.
Hinton
D R
DR
Department of Pathology, USC/University Hospital, Los Angeles County/USC Medical Center, University of Southern California School of Medicine 90033, USA.
Kovacs
K
K
Chandrasoma
P T
PT
D000368:Aged; D010131:Aminosalicylic Acid; D001706:Biopsy; D005260:Female; D006801:Humans; D006818:Hyalin; D007124:Immunoenzyme Techniques; D002479:Inclusion Bodies / Q000737:chemistry / Q000473:pathology; D007633:Keratins / Q000032:analysis; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D008579:Meningioma / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D013238:Stereotaxic Techniques
D010131:Aminosalicylic Acid; D007633:Keratins