Absence of catch-down growth in Russell-Silver syndrome after short-term growth hormone treatment.
We describe 3 children with Russell-Silver syndrome without growth hormone insufficiency who were treated with growth hormone for 2, 3. 7 and 6 years, showing a rapid growth acceleration. After cessation of growth hormone treatment, they grew at a normal rate without 'catch-down' growth. It may be possible that short intra-uterine growth retardation (IUGR) children with dysmorphic features respond to growth hormone therapy differently from non-dysmorphic IUGR short children. Short-term growth hormone treatment for children with Russell-Silver syndrome may avoid side effects and diminish costs.
Azcona
C
C
Department of Endocrinology, Great Ormond Street Hospital for Children, London, UK.c.azcona@ich.ucl.ac.uk
Stanhope
R
R
D000365:Age Determination by Skeleton; D001827:Body Height; D002675:Child, Preschool; D004392:Dwarfism / Q000188:drug therapy* / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D006128:Growth / Q000187:drug effects / Q000502:physiology*; D019382:Human Growth Hormone / Q000172:deficiency* / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011627:Puberty; D012016:Reference Values
D019382:Human Growth Hormone