title: Modulation of multidrug resistance in tumor cells by taxinine derivatives.
abstract: Among a series of taxinine (1) and its designed derivatives (2-33), two taxoids (29 and 33) increased cellular accumulation of vincristine in multidrug-resistant tumor cells more potently than verapamil, while the activities of eight taxoids (11, 14-16, 22, and 30-32) were comparable with that of verapamil. These results reveal that some taxinine derivatives are good modifiers of multidrug resistance in tumor cells.
authors: Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
authors: H
authors: H
authors: Hosoyama
authors: H
authors: H
authors: Shigemori
authors: A
authors: A
authors: Tomida
authors: T
authors: T
authors: Tsuruo
authors: J
authors: J
authors: Kobayashi
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000493:pharmacokinetics; D001952:Bridged-Ring Compounds / Q000737:chemistry / Q000494:pharmacology*; D018432:Drug Resistance, Multiple; D004357:Drug Synergism; D006801:Humans; D051379:Mice; D014407:Tumor Cells, Cultured; D014750:Vincristine / Q000493:pharmacokinetics
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001952:Bridged-Ring Compounds; D014750:Vincristine