Drug-Cyclodextrin Association Constants Determined by Surface Tension and Surface Pressure Measurements.
The complexation reaction between the amphiphilic peptide antibiotic polymyxin B and naturally occurring cyclodextrins, used as potential drug carriers, was quantitatively evaluated from surface tension measurements at various drug concentrations. The association constant, Ka, of polymyxin B:beta-cyclodextrin inclusion complex formation of 1:1 stoichiometry was determined from the change in the drug interfacial activity upon the addition of beta-cyclodextrin at the excess solution concentration (10(-3) M). The obtained Ka value is discussed in terms of molecular matching of the host cyclodextrin cavity and the guest drug molecule. Copyright 1999 Academic Press.
Angelova
A
URA CNRS 1218, Centre d'Etudes Pharmaceutiques, Université Paris-Sud, 5 rue J. B. Clément, Châtenay-Malabry, 92296, France
Ringard-Lefebvre
C
Baszkin
A