Cellulose materials modified by antiseptics and their antimicrobial properties.
Adsorption properties of dressing cellulose materials with respect to surfactant antiseptics were studied. These antiseptics are a complex of the copolymer of N-vinylpyrrolidone and crotonic acid with dimethylbenzylalkylammonium chloride (a synthetic polymer with a wide spectrum of antimicrobial effect) and its low molecular weight analogue (dimethylbenzylalkylammonium chloride). It was established that cellulose materials reversibly adsorb mentioned surfactant antiseptics depending on their concentration in the initial solutions. Maximum release of surfactant antiseptics is achieved at solutions at pH = 7.0. Microbiological tests of cellulose materials modified by antiseptics have shown that they exhibit antimicrobial activity. These results can be used in medical practice in clinics for imparting antimicrobial properties to dressing materials.
Kotelnikova
N E
NE
Institute of Macromolecular Compounds, Russian Academy of Sciences, St. Petersburg, Russia.
Panarin
E F
EF
Zaikina
N A
NA
Kudina
N P
NP
Yongfa
H
H
Su
L S
LS
Bobasheva
A S
AS
Lavrentiev
V V
VV
D000327:Adsorption; D000891:Anti-Infective Agents, Local / Q000737:chemistry*; D001458:Bandages; D001558:Benzethonium / Q000031:analogs & derivatives* / Q000737:chemistry; D001672:Biocompatible Materials; D002482:Cellulose / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008970:Molecular Weight; D011095:Polyethylenes / Q000737:chemistry*; D011760:Pyrrolidinones / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013501:Surface-Active Agents / Q000737:chemistry; D014961:X-Ray Diffraction
D000891:Anti-Infective Agents, Local; D001672:Biocompatible Materials; D011095:Polyethylenes; D011760:Pyrrolidinones; D013501:Surface-Active Agents; C118363:poly(N-vinylpyrrolidone-crotonic acid); D001558:Benzethonium; C042670:N-vinyl-2-pyrrolidinone; D002482:Cellulose; C005106:methylbenzethonium chloride