Anxiolytic- and antidepressant-like effects of an antagonist at glycineB receptors.
L-701,324 [7-chloro-4-hydroxy-3-(3-phenoxy)phenyl-2-(1H)-quinolone], a selective antagonist at glycineB receptors, was studied in behavioral tests used to predict a potential anxiolytic (conflict drinking test in rats, four-plate test in mice) and antidepressant (forced swimming test in rats and mice) activity. In the conflict drinking test in rats, L-701,324 (0.5 mg/kg, but not 0.25 and 1 mg/kg) increased the number of punished licks in a statistically significant manner. In the four-plate test in mice, L-701,324 (2 mg/kg, but no lower doses) significantly increased the number of punished crossings. In the forced swimming test in rats, L-701,324 (0.5 mg/kg) slightly, but statistically significantly, reduced the immobility time; the drug was inactive in doses of 0.25 and 1 mg/kg. In mice, L-701,324 administered only in the highest dose used (2 mg/kg) significantly shortened the immobility time. L-701,324 (given in doses higher then 2 mg/kg) induced motor impairment in animals. The above findings indicate that L-701,324 shows weak anxiolytic- and antidepressant-like activities in the animal models used.
Przegaliński
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Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Tatarczyńska
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Chojnacka-Wójcik
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D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D000927:Anticonvulsants / Q000494:pharmacology; D000928:Antidepressive Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D015363:Quinolones / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D018009:Receptors, Glycine / Q000037:antagonists & inhibitors*; D013550:Swimming / Q000502:physiology; D013997:Time Factors
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D000928:Antidepressive Agents; D015363:Quinolones; D018009:Receptors, Glycine; C094635:L 701324