[Polymorphism of CYP1A1 and CYP2D6 genes in tundra nentses and European populations of western Siberia].
Data on the first examination of the CYP1A1 and CYP2D6 genes' polymorphism in the populations of Tundra Nentsis (Yamalo-Nenetskii Autonomous District) and migrant population of Western Siberia (Novosibirsk oblast and Altaiskii krai) are presented. The frequency of the 2D6*4 mutant allele in Tundra Nentsis, characterized by a two-component Caucasoid and Mongoloid origin, was shown to be intermediate in Caucasoid and Mongoloid populations. The frequencies of the 2D6*4 and 1A1Val* mutant alleles across migrant inhabitants of Western Siberia (Caucasoid populations) were similar to that reported for the Caucasoid populations overall. Distribution of the CYP1A1 genotypes (Ile/Ile, Ile/Val*, and Val*/Val*) in Tundra Nentsis was similar to that found in Mongoloid groups. However, the frequency of the 1A1Val* allele in Tundra Nentsis was 1.5 times higher than that in the Southern Mongoloid populations (Chinese, Koreans, and Japanese).
Duzhak
T G
TG
Institute of Molecular Pathology and Ecological Biochemistry, Russian Academy of Medical Sciences, Novosibirsk, Russia.
Gutkina
N I
NI
Mitrofanov
D V
DV
Afanas'eva
O A
OA
Posukh
O L
OL
Kriukov
Iu A
IuA
Osipova
L P
LP
Liakhovich
V V
VV
D044466:Asian People / Q000235:genetics*; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic; D012800:Siberia; D044465:White People / Q000235:genetics*
D019363:Cytochrome P-450 CYP1A1; D019389:Cytochrome P-450 CYP2D6