Clinical and immunologic aspects of storage mite allergy.
Exposure to storage (nonpyroglyphid) mites has been increasingly recognized as a cause of asthma and rhinitis. Several species have been identified in Europe; e.g., Lepidoglyphus destructor, Acarus farris/siro, Tyrophagus spp., Glycyphagus domesticus, and Blomia tjibodas. Blomia tropicalis, on the other hand, predominates in subtropical and tropical areas. Studies from several countries have shown that IgE-mediated allergy in rural populations is of considerable importance and that storage mites are major allergens. Since these mites are found in homes, especially in regions with damp housing conditions, urban populations are at risk of becoming sensitized. Therefore, sensitization is not restricted only to those with occupational exposure. Several major allergens from storage mites have been identified and characterized. There seems to be a limited allergenic cross-reactivity between storage- and house dust mites. Molecular cloning has demonstrated that the Group 2 allergens from storage mites (Lep d 2 and Tyr p 2) show more than 40% sequence identity with the Group 2 allergens from Dermatophagoides spp. The availability of a large number of recombinant dust mite allergens will make it possible to investigate their homology and the number of allergens required for the diagnosis and treatment of storage mite allergy.
van Hage-Hamsten
M
M
Department of Clinical Immunology, Karolinska Hospital, Stockholm, Sweden. marianne.van.hage-hamsten@mb.ks.se
Johansson
E
E
D000485:Allergens / Q000032:analysis / Q000276:immunology*; D000818:Animals; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology* / Q000473:pathology; D007073:Immunoglobulin E / Q000276:immunology; D008925:Mites / Q000276:immunology*; D012423:Rural Health; D014504:Urban Health
D000485:Allergens; D007073:Immunoglobulin E