[Activation of the immune system in colorectal carcinoma and its assessment].
The immune system of the patients with colorectal cancer is activated. Urinary neopterin is an index of this systemic immune activation, reflecting the circulating activity of interferon-gamma. We have measured urinary neopterin excretion in 34 patients with colorectal cancer. This excretion was significantly higher in our patients compared to reference group (325 +/- 267 vs 169 +/- 62 mumol/mol creatinine, neopterin concentrations were considerably higher in Dukes' stage D disease compared with Dukes' stage B and C disease/561 +/- 372 vs 188 +/- 47 and 250 +/- 142 mu/mol creatinine. Increased neopterin detected the presence of metastatic disease with 90% sensitivity and 87.5% specificity. Authors conclude that urinary neopterin measurement may be useful in the staging of colorectal cancer.
Jandík
P
P
Chirurgická klinika LF UK a FN v Hradci Králové.
Melichar
B
B
Mergancová
J
J
Solichová
D
D
Bures
J
J
Voboril
Z
Z
Lukes
J
J
D014408:Biomarkers, Tumor / Q000652:urine*; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D003404:Creatinine / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D019798:Neopterin / Q000652:urine*; D012680:Sensitivity and Specificity
D014408:Biomarkers, Tumor; D019798:Neopterin; D003404:Creatinine