title: Fibroin allergy. IgE mediated hypersensitivity to silk suture materials.
abstract: Delayed-type hypersensitivity with granulomatous lesions to silk sutures is rather rare. Yet, braided silk sutures often act as a non-immunologic foreign-body and cause a granulomatous inflammatory reaction years after surgery. We report here a case of recurrent granulomas with remarkable infiltration of eosinophils that may have resulted from an IgE-mediated hypersensitivity reaction to silk fibroin, a component of the braided silk suture. Under normal circumstances exposure to fibroin is rather rare. Therefore, the present patient may have developed this reaction to the silk sutures used in a previous surgery.
authors: Department of Otolaryngology, Nippon Medical School, Kanagawa, Japan.
authors: S
authors: S
authors: Kurosaki
authors: H
authors: H
authors: Otsuka
authors: M
authors: M
authors: Kunitomo
authors: M
authors: M
authors: Koyama
authors: R
authors: R
authors: Pawankar
authors: K
authors: K
authors: Matumoto
mesh_terms: D005349:Fibroins / Q000276:immunology*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000209:etiology* / Q000276:immunology; D007073:Immunoglobulin E / Q000032:analysis*; D019476:Insect Proteins / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D047011:Silk; D013537:Sutures / Q000009:adverse effects*
chemical_list: D019476:Insect Proteins; D047011:Silk; D007073:Immunoglobulin E; D005349:Fibroins