Sarcoidosis with selective involvement of a second liver allograft: report of a case and review of the literature.
A case of sarcoidosis recurrent in a patient's second liver allograft is described. There was no granulomatous disease seen in the patient's first liver allograft. After the second orthotopic liver transplantation (OLT), the patient was successfully treated for acute rejection, aspergillus infection, and cytomegalovirus viremia. Approximately 2 months after the second OLT, the patient was treated with long-term interferon-alpha for recurrent hepatitis C. Five years after the operation, he experienced liver failure secondary to recurrent hepatitis and underwent a third OLT. This is only the second reported case of sarcoidosis recurrent in the liver parenchyma of a transplanted organ and the first in which interferon-alpha might have played a role.
Hunt
J
J
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA.
Gordon
F D
FD
Jenkins
R L
RL
Lewis
W D
WD
Khettry
U
U
D000038:Abscess / Q000150:complications; D001228:Aspergillosis / Q000150:complications; D003586:Cytomegalovirus Infections / Q000150:complications; D006084:Graft Rejection / Q000150:complications; D006099:Granuloma / Q000150:complications; D019698:Hepatitis C, Chronic / Q000150:complications / Q000628:therapy; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects / Q000627:therapeutic use; D008107:Liver Diseases / Q000150:complications* / Q000276:immunology* / Q000473:pathology; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012507:Sarcoidosis / Q000150:complications* / Q000276:immunology* / Q000473:pathology
D016898:Interferon-alpha