Leptin resistance in a polygenic, hyperleptinemic animal model of obesity and NIDDM: Psammomys obesus.
OBJECTIVE
To investigate the effects of leptin administration to Psammomys obesus, a polygenic animal model of obesity and type 2 diabetes mellitus.


METHODS
Longitudinal intervention study utilising three separate leptin treatment protocols lasting 7-14 d.


METHODS
Body weight and food intake were measured daily, body fat and muscle content were estimated by carcass analysis on completion of the study. Blood glucose, plasma insulin, leptin, triglycerides and cholesterol were measured at baseline and twice each week during the study.


RESULTS
Relatively high doses of leptin were required to significantly reduce food intake and body fat content in lean Psammomys obesus, but had no discernible effect on their obese littermates.


CONCLUSIONS
As a species, Psammomys obesus appear to be relatively insensitive to the effects of leptin administration, compared with other rodents. Obese Psammomys obesus are leptin resistant relative to their lean littermates.
Walder
K
K
School of Nutrition and Public Health, Deakin University, Geelong, Victoria, Australia.
Lewandowski
P
P
Morton
G
G
Sanigorski
A
A
de Silva
A
A
Zimmet
P
P
Collier
G R
GR
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D003920:Diabetes Mellitus / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D004195:Disease Models, Animal; D004435:Eating / Q000187:drug effects; D002149:Energy Intake / Q000187:drug effects; D005849:Gerbillinae; D007328:Insulin / Q000097:blood; D020738:Leptin; D009765:Obesity; D011506:Proteins / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D007328:Insulin; D020738:Leptin; D011506:Proteins; D014280:Triglycerides; D002784:Cholesterol