Cytomimetic biomaterials. 3. Preparation and transport studies of an alginate/amphiphilic copolymer/polymerized phospholipid film.
The significance of molecular design methodologies based upon membrane-mimetic systems lies in the ability to engineer robust materials of varying geometry with a high degree of reproducibility and molecular control over surface order and chemistry. However, non-covalently associated assemblies, in and of themselves, are often insufficiently robust for many applications. We have previously reported the in situ polymerization of a single phospholipid monolayer on a self-assembled film of octadecyltrichrolosilane (OTS) on glass, as well as the polymerization of phospholipids on an amphiphilic, dialkyl-containing terpolymer bound to a gold-coated silicon wafer. We now report the polymerization of a phospholipid monolayer assembly onto an alkylated hydrogel substrate with significant alteration in both surface chemistry and mass transport properties at the hydrogel-water interface. A general platform is thereby created for enhancing the control of either the local delivery of specific macromolecules or the immunoisolation barrier for many cell based therapies.
Chon
J H
JH
Department of Surgery, Emory University School of Medicine, Atlanta, GA 30322, USA.
Marra
K G
KG
Chaikof
E L
EL
D000464:Alginates / Q000737:chemistry*; D001672:Biocompatible Materials; D001692:Biological Transport; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D016503:Drug Delivery Systems; D020100:Hydrogels; D007457:Iodine Radioisotopes; D008051:Lipid Bilayers / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D010713:Phosphatidylcholines / Q000737:chemistry; D010743:Phospholipids / Q000138:chemical synthesis* / Q000737:chemistry; D011108:Polymers; D013499:Surface Properties
D000464:Alginates; D001672:Biocompatible Materials; D020100:Hydrogels; D007457:Iodine Radioisotopes; D008051:Lipid Bilayers; D010713:Phosphatidylcholines; D010743:Phospholipids; D011108:Polymers