title: Substituted furans as inhibitors of the PDE4 enzyme.
abstract: The synthesis and in vitro activity of a series of substituted furans as a novel structural class of PDE4 inhibitors is described. Comparison of emetic threshold with known PDE4 inhibitors is presented.
authors: Merck Frosst Centre for Therapeutic Research, Pointe Claire-Dorval, Québec, Canada.
authors: H
authors: H
authors: Perrier
authors: C
authors: C
authors: Bayly
authors: F
authors: F
authors: Laliberté
authors: Z
authors: Z
authors: Huang
authors: R
authors: R
authors: Rasori
authors: A
authors: A
authors: Robichaud
authors: Y
authors: Y
authors: Girard
authors: D
authors: D
authors: Macdonald
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000818:Animals; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D005289:Ferrets; D005663:Furans / Q000494:pharmacology*; D010726:Phosphodiesterase Inhibitors / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014839:Vomiting / Q000139:chemically induced
chemical_list: D005663:Furans; D010726:Phosphodiesterase Inhibitors; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4