Inhibition of 4-hydroxyphenylpyruvate dioxygenase by sethoxydim, a potent inhibitor of acetyl-coenzyme A carboxylase.
Sethoxydim, a commercially available cyclohexanedione class herbicide by targeting the enzymatic activity of acetyl-coenzyme A carboxylase, has been found to moderately inhibit the activity of 4-hydroxyphenylpyruvate dioxygenase, a key enzyme in the biosynthesis of plastoquinones and tocopherols in plants.
Lin
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Department of Chemistry, Tunghai Christian University, Taiwan, ROC.
Yang
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D
D015111:4-Hydroxyphenylpyruvate Dioxygenase / Q000037:antagonists & inhibitors*; D000103:Acetyl-CoA Carboxylase / Q000037:antagonists & inhibitors*; D000818:Animals; D003512:Cyclohexanones / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006540:Herbicides / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D013552:Swine
D003512:Cyclohexanones; D004791:Enzyme Inhibitors; D006540:Herbicides; C049437:sethoxydim; D015111:4-Hydroxyphenylpyruvate Dioxygenase; D000103:Acetyl-CoA Carboxylase