title: Glucose metabolism and insulin sensitivity in inactive inflammatory bowel disease.
abstract: BACKGROUND
  Inflammatory mediator concentration was found to be increased in active inflammatory bowel disease, and this could be related to an insulin-resistant state. Moreover, glucocorticoids, which are widely used in the treatment of inflammatory bowel disease, are notoriously related to insulin resistance.
  
  
  OBJECTIVE
  To measure body composition, whole body glucose uptake and oxidation in Crohn's disease and ulcerative colitis patients with inactive disease.
  
  
  METHODS
  All patients had clinical, ultrasound and biochemical assessment. Body composition was determined by isotopic dilution technique; basal metabolic rate and substrate oxidation were measured by indirect calorimetry. Insulin sensitivity was assessed by the euglycaemic hyperinsulinaemic clamp. Ten patients with inactive Crohn's disease (five males, aged 31.1 +/- 7.0 years) and 10 patients with inactive ulcerative colitis (five males, aged 33.4 +/- 8.8 years) participated in the study. Forty healthy subjects, matched for age and height were used as a control group.
  
  
  RESULTS
  Crohn's disease patients showed lower BMI (P < 0.001), fat mass (P < 0.05) and respiratory quotient (P < 0.001) values compared to both ulcerative colitis and control subjects. No difference in peripheral glucose uptake (micromol/kg/min) was found between groups (respectively 42.5 +/- 6.78 in Crohn's disease, 40.2 +/- 8.00 in ulcerative colitis and 41.4 +/- 10.8 in control subjects). Glucose storage and oxidation did not differ between groups.
  
  
  CONCLUSIONS
  Our data showed that inflammatory bowel disease patients in a remission phase of the disease activity had a whole body glucose uptake and oxidation similar to those of control subjects, probably due to fat-free mass preservation and low blood and tissue cytokine concentration.
authors: Department of Internal Medicine, Metabolism Unit. Università Cattolica S. Cuore, Rome, Italy.
authors: E
authors: E
authors: Capristo
authors: G
authors: G
authors: Mingrone
authors: G
authors: G
authors: Addolorato
authors: A V
authors: AV
authors: Greco
authors: G
authors: G
authors: Gasbarrini
mesh_terms: D000293:Adolescent; D000328:Adult; D001823:Body Composition; D002151:Calorimetry; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000378:metabolism*; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction
chemical_list: D005947:Glucose