[Cholinergic receptors in early (pre-nervous) sea urchin embryos].
Agonists of nicotinic acetylcholine receptors (nAChR) nicotine and 1-acetyl-4-methylpiperazine do not act on the early sea urchin embryogenesis but evoke calcium shock in both oocytes and early embryos under certain conditions. Many nAChR ligands protect both oocytes and embryos against this shock. There seem to exist putative nAChR on the cell surface of the early sea urchin oocytes and early embryos. Pre-nervous acetylcholine seems to be functionally coupled via these receptors with the second messengers, endogenous activators of the protein kinase C.
Buznikov
G A
GA
N. K. Kol'tsov Institute of Developmental Biology of the Russian Acad. Sci., Moscow, Russia.
Rakic
L
L
D000109:Acetylcholine / Q000502:physiology; D000818:Animals; D004625:Embryo, Nonmammalian / Q000502:physiology*; D004789:Enzyme Activation; D005260:Female; D066298:In Vitro Techniques; D009538:Nicotine / Q000494:pharmacology; D018722:Nicotinic Agonists / Q000494:pharmacology; D009865:Oocytes; D011493:Protein Kinase C / Q000378:metabolism; D011978:Receptors, Nicotinic / Q000187:drug effects / Q000502:physiology*; D012617:Sea Urchins; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D018722:Nicotinic Agonists; D011978:Receptors, Nicotinic; D009538:Nicotine; D011493:Protein Kinase C; D000109:Acetylcholine; D013755:Tetradecanoylphorbol Acetate