title: (3-substituted benzyl)thiazolidine-2,4-diones as structurally new antihyperglycemic agents.
abstract: A series of 3-[(2,4-dioxothiazolidin-5-yl)methyl]benzamide derivatives was prepared as part of a search for antidiabetic agents. A structure-activity relationship study of these compounds led to the identification of 5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[4-(trifluorome thyl)-phenyl]methyl]benzamide (KRP-297) as a candidate drug for the treatment of diabetes mellitus.
authors: Central Research Laboratories, Kyorin Pharmaceutical Co., Ltd., Tochigi, Japan.
authors: M
authors: M
authors: Nomura
authors: S
authors: S
authors: Kinoshita
authors: H
authors: H
authors: Satoh
authors: T
authors: T
authors: Maeda
authors: K
authors: K
authors: Murakami
authors: M
authors: M
authors: Tsunoda
authors: H
authors: H
authors: Miyachi
authors: K
authors: K
authors: Awano
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D051379:Mice; D008820:Mice, Obese; D000077205:Pioglitazone; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000737:chemistry* / Q000494:pharmacology*; D045162:Thiazolidinediones; D053778:Thiazolidines; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D013844:Thiazoles; D045162:Thiazolidinediones; D053778:Thiazolidines; D014280:Triglycerides; C116017:5-((2,4-dioxo-5-thiazolidinyl)methyl)-2-methoxy-N-((4-(trifluoromethyl)phenyl)methyl)benzamide; D000077205:Pioglitazone