High-throughput screening of historic collections: observations on file size, biological targets, and file diversity.
At Pfizer Central Research, high-throughput screening has been an important source of new leads for drug discovery for a decade. Our experience with over 150 high-throughput screens can address questions about necessary file size, how well particular biological targets fare (with particular reference to protein-protein interactions), and what file diversity means in practice.
Spencer
R W
RW
Pfizer Central Research, Pfizer Inc., Groton, Connecticut 06340, USA.
D016208:Databases, Factual; D015195:Drug Design; D019151:Peptide Library; D011487:Protein Conformation; D012984:Software; D013373:Substance P / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods
D019151:Peptide Library; D013373:Substance P