Oxygen depletion-induced dormancy in Mycobacterium bovis BCG.
Gradual depletion of oxygen causes the shift-down of aerobic growing Mycobacterium bovis BCG to an anaerobic synchronized state of nonreplicating persistence. The persistent culture shows induction of glycine dehydrogenase and alpha-crystallin-like protein and is sensitive to metronidazole.
Lim
A
A
Institute of Molecular and Cell Biology, Singapore 117609, Republic of Singapore.
Eleuterio
M
M
Hutter
B
B
Murugasu-Oei
B
B
Dick
T
T
D000594:Amino Acid Oxidoreductases / Q000096:biosynthesis; D000693:Anaerobiosis; D003459:Crystallins / Q000096:biosynthesis; D004790:Enzyme Induction; D050789:Glycine Dehydrogenase; D008795:Metronidazole; D009163:Mycobacterium bovis / Q000254:growth & development* / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism*
D003459:Crystallins; D008795:Metronidazole; D000594:Amino Acid Oxidoreductases; D050789:Glycine Dehydrogenase; D010100:Oxygen