Mucinous vacuolar change of porcine urothelium induced by regional embolism or cryoablation.
Porcine urinary tract epithelium responds to systemic infections with an increase in mucin secretion that has been called "mucinous degeneration." Here we describe similar changes in calyceal, pelvic, and ureteric urothelium in pig renal tracts 14 days after local embolism and cryoablation (four kidneys) or cryoablation alone (six kidneys). Large mucin-filled vacuoles surrounded by smaller cytoplasmic vesicles were present in the affected urothelium but were rare in calyceal urothelium of normal kidneys. These mucinous vacuolar changes were proportional to the extent of renal necrosis and could be important in the pathologic responses of xenotransplanted pig kidneys.
Warner
T F
TF
Surgical Pathology, University of Wisconsin Hospital and Clinics, Madison 53792, USA.
Nakada
S Y
SY
Lee
F T
FT
Salisbury
S
S
Chosy
S G
SG
Moon
T D
TD
D000818:Animals; D003452:Cryosurgery / Q000009:adverse effects / Q000662:veterinary*; D004621:Embolization, Therapeutic / Q000009:adverse effects / Q000662:veterinary*; D006651:Histocytochemistry; D007668:Kidney / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D008854:Microscopy, Electron / Q000662:veterinary; D009077:Mucins / Q000378:metabolism; D013552:Swine; D013553:Swine Diseases / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D014513:Ureter / Q000473:pathology* / Q000648:ultrastructure; D019459:Urothelium / Q000473:pathology; D014617:Vacuoles / Q000473:pathology
D009077:Mucins