title: Potentiation of isoniazid activity against Mycobacterium tuberculosis by melatonin.
abstract: The limited number of effective antituberculosis drugs available necessitates optimizing current treatments. We show that melatonin, which is synthesized in the pineal gland, can cause at least a threefold increase in the efficacy of isoniazid. This suggests that tuberculosis chemotherapy can be improved by innate molecules such as melatonin.
authors: MRC Centre For Molecular and Cellular Biology, Department of Medical Biochemistry, University of Stellenbosch Medical School, Tygerberg, South Africa.
authors: I
authors: I
authors: Wiid
authors: E
authors: E
authors: Hoal-van Helden
authors: D
authors: D
authors: Hon
authors: C
authors: C
authors: Lombard
authors: P
authors: P
authors: van Helden
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000494:pharmacology*; D018432:Drug Resistance, Multiple; D004357:Drug Synergism; D006801:Humans; D007538:Isoniazid / Q000494:pharmacology*; D008550:Melatonin / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000166:cytology / Q000187:drug effects*
chemical_list: D000975:Antioxidants; D000995:Antitubercular Agents; D008550:Melatonin; D007538:Isoniazid