Effects of long term feeding of raw soya bean flour on virus-induced pancreatic carcinogenesis in guinea fowl.
The effects of a diet enriched with 25% raw soya bean flour (RSF) on the pancreas and on the avian retrovirus Pts 56-induced pancreatic carcinogenesis in guinea fowl were studied. It has been shown that prolonged RSF feeding of new-hatched virus-infected and uninfected guinea fowl-poults induced enlargement of the pancreas, which was less pronounced when administration of the RSF supplemented diet started at the age of 75 days. Time-dependent multifocal inter- and intralobular hyperplasia of pleomorphic ducts lined by mucin-producing epithelium in the exocrine pancreas of virus-infected guinea fowls fed a RSF supplemented diet was regularly observed. Enlargement of virus-induced ductular neoplasms has been shown only after simultaneous RSF and virus administration.
Kirev
T
T
Institute of Experimental Pathology and Parasitology, Bulgarian Academy of Sciences, Sofia.
Woutersen
R A
RA
Kiril
A
A
D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight; D015197:Carcinogenicity Tests; D003043:Cocarcinogenesis; D005260:Female; D005433:Flour / Q000009:adverse effects*; D006965:Hyperplasia / Q000209:etiology / Q000821:virology; D008297:Male; D010179:Pancreas / Q000473:pathology; D010183:Pancreatic Ducts / Q000473:pathology / Q000821:virology; D010190:Pancreatic Neoplasms / Q000209:etiology* / Q000473:pathology / Q000821:virology; D011200:Poultry; D011897:Random Allocation; D012190:Retroviridae; D012192:Retroviridae Infections / Q000150:complications*; D013025:Glycine max; D014412:Tumor Virus Infections / Q000150:complications*