[Neurotoxicity of the environmental pollutants: tin (Sn2+) effects on currents induced by acetylcholine in the snail neurons].
In isolated single neurone or in whole ganglia preparation, SnCl2 caused a decrease in the acetylcholine-induced inward current in a dose-dependent way. Threshold concentration was 0.1 mkM and saturated at 5 mkM SnCl2. After 10-min. pre-treatment with SnCl2 the effect was more obvious (by 20%) than after 3-min pre-treatment. Sn(CH3)2 decreased the amplitude of Ach-induced current similarly to the inorganic Sn. The effect of Sn(CH3)2 was irreversible. The findings support earlier data that the agonist-activated channels are important targets for toxic metals. Direct action upon neuronal membrane seems to be an important event in modulation of synaptic transmission.
Salanki
J
J
Balaton Lymnological Research Institute of the Hungarian Acad. Sci., Tihany, Hungary.
Gyeri
J
J
Platokhin
A
A
Rozsa
K S
KS
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D004785:Environmental Pollutants / Q000009:adverse effects*; D017952:Ganglia, Invertebrate / Q000166:cytology / Q000187:drug effects; D066298:In Vitro Techniques; D008195:Lymnaea; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D009947:Organotin Compounds / Q000633:toxicity*; D017971:Tin Compounds / Q000633:toxicity*
D004785:Environmental Pollutants; D009947:Organotin Compounds; D017971:Tin Compounds; D000109:Acetylcholine