title: Risk factors for rupture of chronic type B dissections.
abstract: OBJECTIVE
  This study was an attempt to determine risk factors for rupture and to improve management of patients with type B aortic dissection who survive the acute phase without operation.
  
  
  METHODS
  We studied 50 patients by means of serial computer-generated 3-dimensional computed tomographic scans. All patients who did not undergo operative treatment before the completion of at least 2 computed tomographic scans a minimum of 3 months apart after an acute type B dissection were included in the study. The median duration of follow-up was 40 months (range 0.9-112 months). Only 1 patient died of causes unrelated to the aneurysm during follow-up. Nine patients had fatal rupture (18%); 10 patients underwent elective aneurysm resection because of rapid expansion or development of symptoms, and 31 patients remained alive without operation or rupture. Possible risk factors for rupture in patients in the rupture, operative, and event-free groups were compared, as were dimensional data from first follow-up and last computed tomographic scans.
  
  
  RESULTS
  Older age, chronic obstructive pulmonary disease, and elevated mean blood pressures were unequivocally associated with rupture (rupture versus event-free survival, P <.05), and pain was marginally significantly associated. Analysis of dimensional factors contributing to rupture was complicated by the fact that patients who underwent elective operation had significantly larger aneurysms and faster expansion rates than did either of the other groups, leaving comparisons of aneurysmal diameter between groups with and without rupture showing only marginal statistical significance. The last median descending aortic diameter before rupture in the rupture group was 5.4 cm (range 3.2-6. 7 cm).
  
  
  CONCLUSIONS
  In an environment in which patients with large and rapidly expanding aneurysms are usually referred for surgical treatment, older patients with chronic type B dissections, especially if they have uncontrolled hypertension and a history of chronic obstructive pulmonary disease, are significantly more likely to have rupture than are younger, normotensive patients without lung disease. Neither the presence of a persistently patent false lumen nor a large abdominal aortic diameter appears to increase the risk of rupture. Overall, our nondimensional data strikingly resemble the natural history of patients with nondissecting aneurysms, suggesting that calculations derived from data on chronic descending thoracic and thoracoabdominal aneurysms would provide an overly conservative individual estimate of rupture risk for patients with chronic type B dissection, who tend toward earlier rupture of smaller aneurysms. A more aggressive surgical approach toward treatment of patients with chronic type B dissection seems warranted.
authors: Departments of Cardiothoracic Surgery and Biomathematics, Mount Sinai School of Medicine, New York, USA.
authors: T
authors: T
authors: Juvonen
authors: M A
authors: MA
authors: Ergin
authors: J D
authors: JD
authors: Galla
authors: S L
authors: SL
authors: Lansman
authors: J N
authors: JN
authors: McCullough
authors: K
authors: K
authors: Nguyen
authors: C A
authors: CA
authors: Bodian
authors: M P
authors: MP
authors: Ehrlich
authors: D
authors: D
authors: Spielvogel
authors: J J
authors: JJ
authors: Klein
authors: R B
authors: RB
authors: Griepp
mesh_terms: D000367:Age Factors; D000784:Aortic Dissection / Q000145:classification / Q000453:epidemiology* / Q000601:surgery; D017545:Aortic Aneurysm, Thoracic / Q000145:classification / Q000453:epidemiology* / Q000601:surgery; D001019:Aortic Rupture / Q000145:classification / Q000453:epidemiology* / Q000601:surgery; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D015996:Survival Rate; D013997:Time Factors; D014057:Tomography, X-Ray Computed