title: MRI abnormalities associated with partial status epilepticus.
abstract: OBJECTIVE
  To report neuroimaging findings in patients with complex partial status epilepticus.
  
  
  BACKGROUND
  During status epilepticus, neuroimaging may be used to exclude other neurologic conditions. Therefore, it is important to identify the neuroimaging features that are associated with status epilepticus. In addition, MRI characteristics may provide insight into the pathophysiologic changes during status epilepticus.
  
  
  METHODS
  The history and neuroimaging examination results of three patients with complex partial status epilepticus were reviewed. Studies obtained during status epilepticus included diffusion-weighted MRI (DWI), MR angiography (MRA), postcontrast T1-weighted MRI, T2-weighted MRI, and CT. Follow-up MRI was obtained in two patients, and autopsy results were available for the third.
  
  
  RESULTS
  Some of the MRI and CT findings during partial status epilepticus mimicked those of acute ischemic stroke: DWI and T2-weighted MRI showed cortical hyperintensity with a corresponding low apparent diffusion coefficient, and CT showed an area of decreased attenuation with effacement of sulci and loss of gray-white differentiation. However, the lesions did not respect vascular territories, there was increased signal of the ipsilateral middle cerebral artery on MRA, and leptomeningeal enhancement appeared on postcontrast MRI. On follow-up imaging, the abnormalities had resolved, but some cerebral atrophy was present.
  
  
  CONCLUSIONS
  The radiologic characteristics of status epilepticus resemble those of ischemic stroke but can be differentiated based on lesion location and findings on MRA and postcontrast MRI. The MRI abnormalities indicated the presence of cytotoxic and vasogenic edema, hyperperfusion of the epileptic region, and alteration of the leptomeningeal blood-brain barrier. These changes reversed, but they resulted in some regional brain atrophy.
authors: Stanford Stroke Center, UCSF Stanford Health Care, Palo Alto, CA 94304-1705, USA.
authors: M G
authors: MG
authors: Lansberg
authors: M W
authors: MW
authors: O'Brien
authors: A M
authors: AM
authors: Norbash
authors: M E
authors: ME
authors: Moseley
authors: M
authors: M
authors: Morrell
authors: G W
authors: GW
authors: Albers
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D013226:Status Epilepticus / Q000473:pathology*