title: Studies of human immunodeficiency virus type 1 mucosal viral shedding and transmission in Kenya.
abstract: If human immunodeficiency virus type 1 (HIV-1) vaccines are to be highly effective, it is essential to understand the virologic factors that contribute to HIV-1 transmission. It is likely that transmission is determined, in part, by the genotype or phenotype (or both) of infectious virus present in the index case, which in turn will influence the quantity of virus that may be exchanged during sexual contact. Transmission may also depend on the fitness of the virus for replication in the exposed individual, which may be influenced by whether a virus encounters a target cell that is susceptible to infection by that specific variant. Of interest, our data suggest that the complexity of the virus that is transmitted may be different in female and male sexual exposures.
authors: Program in Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA. joverbau@fhcrc.org. joverbau@fhcrc.org
authors: J
authors: J
authors: Overbaugh
authors: J
authors: J
authors: Kreiss
authors: M
authors: M
authors: Poss
authors: P
authors: P
authors: Lewis
authors: S
authors: S
authors: Mostad
authors: G
authors: G
authors: John
authors: R
authors: R
authors: Nduati
authors: D
authors: D
authors: Mbori-Ngacha
authors: H
authors: H
authors: Martin
authors: B
authors: B
authors: Richardson
authors: S
authors: S
authors: Jackson
authors: J
authors: J
authors: Neilson
authors: E M
authors: EM
authors: Long
authors: D
authors: D
authors: Panteleeff
authors: M
authors: M
authors: Welch
authors: J
authors: J
authors: Rakwar
authors: D
authors: D
authors: Jackson
authors: B
authors: B
authors: Chohan
authors: L
authors: L
authors: Lavreys
authors: K
authors: K
authors: Mandaliya
authors: J
authors: J
authors: Ndinya-Achola
authors: J
authors: J
authors: Bwayo
mesh_terms: D000328:Adult; D001942:Breast Feeding; D004196:Disease Outbreaks; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000453:epidemiology / Q000235:genetics / Q000635:transmission* / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000235:genetics; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D007630:Kenya / Q000453:epidemiology; D008297:Male; D017201:Virus Shedding