The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene.
E-cadherin-mediated cell-cell adhesion is lost during the development of most epithelial cancers. Recent evidence indicates that the loss of E-cadherin function, besides causing loss of cell-cell adhesion, might also convey signals that actively induce tumour-cell invasion and metastasis.
Christofori
G
G
Research Institute of Molecular Pathology, Vienna, Austria. christofori@nt.imp.univie.ac.at
Semb
H
H
D000818:Animals; D015820:Cadherins / Q000235:genetics* / Q000502:physiology; D002448:Cell Adhesion / Q000235:genetics; D016147:Genes, Tumor Suppressor; D006706:Homeostasis; D006801:Humans; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000209:etiology / Q000235:genetics / Q000503:physiopathology; D015398:Signal Transduction
D015820:Cadherins