Effect of clofibrate, a peroxisome proliferator, in sea bass (Dicentrarchus labrax), a marine fish.
The effects of 35 or 70 mg/kg clofibrate on some peroxisomal, mitochondrial, and microsomal enzymes (markers of peroxisome proliferation) in liver, gill, and kidney of sea bass following 2 weeks i.p. treatment have been studied. Induction of lauric acid hydroxylase, UDP-glucuronyl transferase, palmitoyl-CoA oxidase, carnitine-palmitoyl-transferase, p-nitrophenylacetate hydrolase, and benzaldehyde and propionaldehyde dehydrogenase activities was not observed in any case. The clofibrate administration at the dose of 70 mg/kg induced in the liver the glutathione S-tranferase and reduced epoxide hydrolase activities. These results demonstrate that a marine fish species, such as sea bass, is refractory to peroxisome proliferation.
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Dipartimento di Patologia Animale, Profilassi ed Igiene degli Alimenti, V.le delle Piagge 2, Pisa, 56124, Italy.
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Gervasi
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D000818:Animals; D001492:Bass / Q000378:metabolism*; D002994:Clofibrate / Q000494:pharmacology*; D004851:Epoxide Hydrolases / Q000037:antagonists & inhibitors; D005982:Glutathione Transferase / Q000096:biosynthesis; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008830:Microbodies / Q000187:drug effects / Q000201:enzymology; D008861:Microsomes / Q000187:drug effects / Q000201:enzymology; D008928:Mitochondria / Q000187:drug effects / Q000201:enzymology; D020025:Peroxisome Proliferators / Q000494:pharmacology*
D020025:Peroxisome Proliferators; D005982:Glutathione Transferase; D004851:Epoxide Hydrolases; D002994:Clofibrate