Molecular epidemiology of respiratory syncytial virus in The Gambia.
Respiratory syncytial virus (RSV) infection in The Gambia occurs seasonally in association with the rainy season. This study examined the genetic variability of RSV isolates from four consecutive epidemics from 1993-6. Each epidemic was made up of a number of variants which were replaced in subsequent epidemics. Analysis of attachment (G) protein gene sequences showed that isolates were closely related to those observed in the rest of the world. However, many isolates from 1993 and 1994 were unlike other isolates observed in the developed world during this period and were more similar to isolates from 1984 in Europe. In addition, the most commonly observed genotype in the UK in the 1990s was not detected in The Gambia during this period.
Cane
P A
PA
Division of Immunity and Infection, University of Birmingham Medical School, UK.
Weber
M
M
Sanneh
M
M
Dackour
R
R
Pringle
C R
CR
Whittle
H
H
D000595:Amino Acid Sequence; D001483:Base Sequence; D004279:DNA, Viral / Q000235:genetics*; D003906:Developing Countries; D005714:Gambia / Q000453:epidemiology; D014644:Genetic Variation / Q000235:genetics; D005838:Genotype; D006801:Humans; D015994:Incidence; D007223:Infant; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D010802:Phylogeny; D011159:Population Surveillance; D018357:Respiratory Syncytial Virus Infections / Q000453:epidemiology* / Q000821:virology*; D018113:Respiratory Syncytial Virus, Human / Q000145:classification / Q000235:genetics*; D015183:Restriction Mapping; D012621:Seasons; D012703:Serotyping
D004279:DNA, Viral