title: Dose selection in stereotactic radiosurgery.
abstract: Selection of the prescription dose for radiosurgery is the final step in treatment planning. Dose selection should take into account the expectation of treatment success (i.e., tumor control, arteriovenous malformation [AVM] obliteration, and so forth) and complication risks at various doses. Accurately predicting complication risks for individual patients is a complex process that is highly dependent on the radiosurgery treatment volume, the target location, and the nature of the target tissue. Dose-response data for desired outcomes of radiosurgery are sparse and difficult to interpret for most indications, with perhaps the exception of AVM obliteration. This article reviews the principles governing dose-selection and the evolving body of data guiding dose selection in radiosurgery.
authors: Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
authors: J C
authors: JC
authors: Flickinger
authors: D
authors: D
authors: Kondziolka
authors: L D
authors: LD
authors: Lunsford
mesh_terms: D001921:Brain / Q000528:radiation effects / Q000601:surgery; D001927:Brain Diseases / Q000601:surgery*; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008959:Models, Neurological; D010347:Patient Care Planning; D017410:Practice Guidelines as Topic; D011829:Radiation Dosage; D016634:Radiosurgery / Q000379:methods* / Q000592:standards