title: Expression of the neural cell adhesion molecule in mouse taste buds after denervation.
abstract: Expression of the neural cell adhesion molecule (NCAM) was studied by use of an immunocytochemical technique in the taste buds of mouse circumvallate papillae after bilateral transection of the glossopharyngeal nerves. In untreated mice, innervated type-III cells reacted with anti-NCAM antibody. After denervation the taste buds gradually decreased in number and size, and were practically absent within 11 days. In parallel, NCAM-reactive cells decreased at 3 and 8 days after surgery and at 11 days they were no longer found. Three days after denervation, synaptic contacts between type-III cells and nerve fibres were not found because of the disappearance of nerve fibres. However, remaining type-III cells, characterized with dense-cored vesicles, still maintained NCAM expression on their plasma membrane until day 8.
authors: Department of Anatomy, School of Dentistry, Health Sciences University of Hokkaido, Japan.
authors: M
authors: M
authors: Takeda
authors: Y
authors: Y
authors: Suzuki
authors: N
authors: N
authors: Obara
authors: W
authors: W
authors: Breipohl
mesh_terms: D000818:Animals; D003714:Denervation; D007150:Immunohistochemistry; D051379:Mice; D016253:Microscopy, Immunoelectron; D019006:Neural Cell Adhesion Molecules / Q000302:isolation & purification*; D013650:Taste Buds / Q000502:physiology* / Q000648:ultrastructure
chemical_list: D019006:Neural Cell Adhesion Molecules