The low-density lipoprotein receptor gene family: multiple roles in lipid metabolism.
The low-density lipoprotein receptor gene family encompasses a class of endocytic receptors that exhibit structural similarities to the low-density lipoprotein receptor. Members of this gene family are present in both vertebrate and nonvertebrate species. The identification of naturally occurring mutations and the application of gene targeting to inactivate receptor genes enabled us to develop animal models to investigate the consequences of individual receptor defects in vivo. Analysis of these animal models revealed exciting new functions of lipoprotein receptors not only in systemic clearance of lipoproteins but also in other important biological processes including reproduction, brain development. and adipositas.
Willnow
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Max-Delbrück-Center, Berlin, Germany. willnow@mdc-berlin.de
D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics; D002645:Chickens / Q000235:genetics; D002914:Chylomicrons / Q000378:metabolism; D004331:Drosophila melanogaster / Q000235:genetics; D004527:Egg Proteins; D004815:Epidermal Growth Factor / Q000378:metabolism; D005260:Female; D006056:Golgi Apparatus / Q000378:metabolism; D026541:Heymann Nephritis Antigenic Complex; D006801:Humans; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D008431:Maternal-Fetal Exchange; D008562:Membrane Glycoproteins / Q000378:metabolism; D051379:Mice; D008954:Models, Biological; D005810:Multigene Family; D011247:Pregnancy; D011817:Rabbits; D011956:Receptors, Cell Surface / Q000378:metabolism; D011973:Receptors, LDL / Q000235:genetics* / Q000378:metabolism / Q000502:physiology
D002914:Chylomicrons; D004527:Egg Proteins; D026541:Heymann Nephritis Antigenic Complex; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D011973:Receptors, LDL; C036053:VLDL receptor; C030474:vitellogenin receptor; D004815:Epidermal Growth Factor