Structural Change in Dextran: Mechanism of Insolubilization by Adsorption on the Air-Liquid Interface.
To clarify the insolubilization mechanism of water-soluble dextran, the association of dextran in water was studied by dynamic light scattering measurements and a surface chemical approach. Dynamic light scattering measurements indicated that insolubilization of dextran is accompanied by a structural change in dextran. Surface tension data for dextran molecules revealed a structural change in dextran molecules at the air-liquid interface. These results suggest that insolubilization of dextran molecules occurred through an adsorption process at the air-liquid interface. Insolubilization of dextran molecules can be reduced by inhibition of this structural change in dextran molecules. The presence of boron as an impurity was found to trigger precipitation based on inductively coupled plasma mass spectrometry measurements and precipitation tests. Copyright 1999 Academic Press.
Hirata
Y
Formulation Research Institute, Otsuka Pharmaceutical Factory, Inc., Kuguhara 115, Tateiwa, Muya-cho, Naruto, Tokushima, Japan
Sano
Y
Aoki
M
Kobatake
H
Kato
S
Yamamoto
H