Potentiation of isoniazid activity against Mycobacterium tuberculosis by melatonin.
The limited number of effective antituberculosis drugs available necessitates optimizing current treatments. We show that melatonin, which is synthesized in the pineal gland, can cause at least a threefold increase in the efficacy of isoniazid. This suggests that tuberculosis chemotherapy can be improved by innate molecules such as melatonin.
Wiid
I
I
MRC Centre For Molecular and Cellular Biology, Department of Medical Biochemistry, University of Stellenbosch Medical School, Tygerberg, South Africa.
Hoal-van Helden
E
E
Hon
D
D
Lombard
C
C
van Helden
P
P
D000975:Antioxidants / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000494:pharmacology*; D018432:Drug Resistance, Multiple; D004357:Drug Synergism; D006801:Humans; D007538:Isoniazid / Q000494:pharmacology*; D008550:Melatonin / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000166:cytology / Q000187:drug effects*
D000975:Antioxidants; D000995:Antitubercular Agents; D008550:Melatonin; D007538:Isoniazid