Frequency of invasive cancer in surgically excised vulvar lesions with intraepithelial neoplasia (VIN 3).
OBJECTIVE
The aim of this study was to determine the frequency of invasive cancer found from specimens removed by surgical excision on patients with diagnosis of VIN 3.


METHODS
Seventy-eight patients with biopsy-proven vulvar intraepithelial neoplasia 3 (VIN 3) were treated by surgical excision.


RESULTS
Sixteen patients (20.5%) were found to have invasion in the excised surgical specimen. Superficial invasion was seen in 7 patients (9%), 9 were noted to have >1 mm invasion (11.5%), and 1 patient had in situ Paget's disease (1.3%).


CONCLUSIONS
Surgical excision should be considered a preferable method in management of patients with VIN 3.
Husseinzadeh
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Division of Gynecologic Oncology, University of Cincinnati College of Medicine, Cincinnati, Ohio, 45267-0526, USA.
Recinto
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C
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002278:Carcinoma in Situ / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D014846:Vulvar Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery