[Brain damage caused by hypotensive anesthesia? Both the anesthetic technique and the anesthetic agent must be chosen with care].
During the fifty years since hypotensive anaesthesia, induced hypotension to minimise intraoperative blood loss, became an established routine, there have been few reports of associated cerebral complications. However, evidence of disturbed cerebral function among patients undergoing orthognathic surgery under induced hypotension was obtained in a recent study where the level of adenylate kinase activity in cerebrospinal fluid was used as a highly sensitive biochemical marker of brain cell injury. Moreover, psychometric tests revealed persistent postoperative mental deterioration. The underlying cause of brain cell injury seems to be complex, and as in all likelihood it is not hypotension per se that is responsible, the effect of the anaesthetic agents used (isoflurane and propofol) has to be considered. It was also noted that hypotension did not improve the clinical outcome of orthognathic surgery, as compared with comparable operations performed under normotension.
Frithz
G
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Medicinska kliniken, Mälarsjukhuset, Eskilstuna.
D000263:Adenylate Kinase / Q000134:cerebrospinal fluid; D000768:Anesthesia, General / Q000009:adverse effects* / Q000379:methods; D018681:Anesthetics, General / Q000009:adverse effects*; D015415:Biomarkers / Q000032:analysis; D001921:Brain / Q000187:drug effects / Q000201:enzymology / Q000503:physiopathology*; D001925:Brain Damage, Chronic / Q000139:chemically induced / Q000201:enzymology / Q000209:etiology*; D006801:Humans; D007023:Hypotension, Controlled
D018681:Anesthetics, General; D015415:Biomarkers; D000263:Adenylate Kinase