title: Worsening of levodopa-induced dyskinesias by motor and mental tasks.
abstract: Ten patients who had Parkinson's disease with disabling dyskinesia were included in this study to evaluate the role of mental (mental calculation) and motor (flexion/extension of right fingers, flexion/extension of left fingers, flexion/extension of the neck, speaking aloud) tasks on the worsening of peak-dose dyskinesia following administration of an effective single dose of apomorphine. Compared with the score at rest (1.3+/-0.3), a significant aggravation of the dyskinesia score was observed during speaking aloud (5.2+/-1.1, p<0.05), movements of right (4.5+/-1.0, p<0.05) and left (3.7+/-0.8, p<0.05) fingers, movements of the neck (5.1+/-1.0, p<0.05), and mental calculation (3.1+/-1.0, p<0.05). These results suggest that activation tasks such as "speaking aloud" could be used for objective assessment of dyskinesia severity.
authors: Department of Neurology, Fédération de Neurologie, CHU Clermont-Ferrand, France.
authors: F
authors: F
authors: Durif
authors: M
authors: M
authors: Vidailhet
authors: B
authors: B
authors: Debilly
authors: Y
authors: Y
authors: Agid
mesh_terms: D000704:Analysis of Variance; D000978:Antiparkinson Agents / Q000009:adverse effects*; D001058:Apomorphine; D004409:Dyskinesia, Drug-Induced / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007980:Levodopa / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology*; D011340:Problem Solving / Q000502:physiology; D012720:Severity of Illness Index; D013060:Speech / Q000502:physiology; D014836:Volition / Q000502:physiology
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa; D001058:Apomorphine