Single-administration vaccines: controlled-release technology to mimic repeated immunizations.
The most effective mechanism for the elimination of disease from society is the use of vaccinations, but these often require repeated administration. However, single-administration vaccine formulations provide the repeated administrations automatically. One approach is the development of injectable controlled-release microsphere formulations containing the vaccine antigen that is released as a pulse 1-6 months after injection. The time of the pulse is dependent upon the rate of polymer degradation, which is dictated by the polymer's composition and molecular weight. This controlled-release technology may provide complete protection against disease after a single administration.
Cleland
J L
JL
Pharmaceutical R&D, Genentech, South San Francisco, CA 94080, USA. cleland@gene.com
D003187:Compliance; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D015699:HIV Envelope Protein gp120 / Q000276:immunology; D007114:Immunization; D008863:Microspheres; D011100:Polyglycolic Acid / Q000494:pharmacology; D013997:Time Factors; D014612:Vaccines / Q000008:administration & dosage*
D003692:Delayed-Action Preparations; D015699:HIV Envelope Protein gp120; D014612:Vaccines; D011100:Polyglycolic Acid