Efficacy of a new quarternary ammonium compound against TB.
Ten of 12 strains of Mycobacteria (11 M. tuberculosis, 1 M. bovis) including 7 resistant strains were found to be sensitive to tetradecyl-dimethyl-benzyl-ammonium fluoride (TDBAF) at a concentration of 15-7.75 micrograms/ml (end point 10 micrograms/ml). A single multi-resistant strain of M. tuberculosis and a culture of M. bovis were also sensitive but at a slightly higher level.
Byrne
C
C
Department of Microbiology, Peamount Hospital, Newcastle, Co., Dublin.
Healy
T M
TM
D000995:Antitubercular Agents / Q000494:pharmacology*; D001548:Benzalkonium Compounds / Q000494:pharmacology*; D018432:Drug Resistance, Multiple; D006801:Humans; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000187:drug effects*; D012680:Sensitivity and Specificity; D013045:Species Specificity; D014376:Tuberculosis / Q000188:drug therapy
D000995:Antitubercular Agents; D001548:Benzalkonium Compounds; C005883:zephiramine