Remangilones A-C, new cytotoxic triterpenes from Physena madagascariensis.
Three new 24,28-dinorolean-3-one derivatives, the remangilones A-C (1-3), were isolated from the dried leaves of Physena madagascariensis using a human mammary carcinoma cell line to guide the isolation. The structures of 1-3 were deduced primarily from NMR studies. Compounds 1 and 3, remangilones A and C, respectively, were found to be cytotoxic against two human breast cancer cell lines and induced apoptosis at concentrations of 2.3 microM.
Deng
Y
Y
Department of Chemistry, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA.
Jiang
T Y
TY
Sheng
S
S
Tianasoa-Ramamonjy
M
M
Snyder
J K
JK
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000473:pathology; D004354:Drug Screening Assays, Antitumor; D004847:Epithelial Cells / Q000187:drug effects; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; C119159:remangilone A; C119161:remangilone B; C119162:remangilone C