title: Reversal of P-glycoprotein mediated multidrug resistance by novel anthranilamide derivatives.
abstract: We have synthesised and evaluated a series of anthranilamide based modulators of P-glycoprotein. These studies have identified XR9576(2), a potent inhibitor of P-glycoprotein in vitro and in vivo. The general synthesis and the SAR of these compounds are described.
authors: Xenova Ltd., Slough, England.
authors: M
authors: M
authors: Roe
authors: A
authors: A
authors: Folkes
authors: P
authors: P
authors: Ashworth
authors: J
authors: J
authors: Brumwell
authors: L
authors: L
authors: Chima
authors: S
authors: S
authors: Hunjan
authors: I
authors: I
authors: Pretswell
authors: W
authors: W
authors: Dangerfield
authors: H
authors: H
authors: Ryder
authors: P
authors: P
authors: Charlton
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism*; D004317:Doxorubicin / Q000494:pharmacology; D018432:Drug Resistance, Multiple; D004357:Drug Synergism; D006801:Humans; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured; D062367:ortho-Aminobenzoates / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D062367:ortho-Aminobenzoates; D004317:Doxorubicin; C000219:anthranilamide