[Aristolochic acids in herbal medicines].
Aristolochic acids are nitrophenanthrenes with a carboxylic acid fanction which have been found only among the Aristolochiaceae. In 1993, rapidly progressive interstitial renal fibrosis has been reported in women have been on a slimming regimen including Chinese herbal medicines in Belgium. In Japan, at the Kansai district, several cases of Chinese herbs nephropathy have been reported quite recently. In both cases, aristolochic acids was detected in the Chinese herbal medicines taken by the patients. We have Asiasarum Root, a species of Aristolochiaceae, in Japanese Pharmacopoeia. Therefore, we quantitatively analysed aristolochic acids in these herbal medicines and related plants.
Sekita
S
S
sekita@nihs.go.jp
Kamakura
H
H
Yasuda
I
I
Hamano
T
T
Satake
M
M
D000970:Antineoplastic Agents / Q000032:analysis* / Q000633:toxicity; D034341:Aristolochic Acids; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D005260:Female; D006801:Humans; D009395:Nephritis, Interstitial / Q000139:chemically induced; D010616:Phenanthrenes / Q000032:analysis* / Q000633:toxicity; D010946:Plants, Medicinal / Q000737:chemistry*
D000970:Antineoplastic Agents; D034341:Aristolochic Acids; D004365:Drugs, Chinese Herbal; D010616:Phenanthrenes; C000228:aristolochic acid I