[Studies on development and improvement of toxicity guidelines conducted at the Biological Safety Research Center].
From FY 1990, studies aimed at development and improvement of toxicity guidelines have been conducted at the Biological Safety Research Center, in collaboration with the Environmental Health Bureau. To date, researches have focused on acute toxicity, antigenicity, reproductive toxicity, immunotoxicity, etc. In this report, brief summary of studies on cytotoxicity, toxicokinetics, neurotoxicity, genetic toxicity and structure-activity relationship performed during FY 1995-97, is presented.
Inoue
T
T
Ohno
Y
Y
Takahshi
M
M
Sofuni
T
T
Nakadate
M
M
Korokawa
Y
Y
D000818:Animals; D001562:Benzimidazoles / Q000633:toxicity*; D001973:Bromodeoxyuridine / Q000633:toxicity*; D002478:Cells, Cultured; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D008223:Lymphoma / Q000473:pathology; D051379:Mice; D009154:Mutation; D009420:Nervous System / Q000187:drug effects / Q000473:pathology; D051381:Rats; D013329:Structure-Activity Relationship; D013937:Thymidine Kinase / Q000235:genetics; D018675:Toxicity Tests / Q000379:methods*; D014466:Ultraviolet Rays
D001562:Benzimidazoles; C030698:2-mercaptobenzimidazole; D013937:Thymidine Kinase; D001973:Bromodeoxyuridine