title: Liquid phase combinatorial synthesis of benzylpiperazines.
abstract: A novel method for soluble, inexpensive polymer-supported synthesis of piperazine and piperidine libraries on the basis of nucleophilic benzylic substitution and N-acylation is reported. Disubstituted piperazine and piperidine derivatives, that are potential drug candidates, can be isolated in high yields and excellent purity by simple precipitation and washing. This liquid phase method proves to be a useful tool for constructing combinatorial libraries containing diamine moieties.
authors: Institute of Chemistry, National Dong Hwa University, Shou-Feng, Hualien, Taiwan.
authors: J Y
authors: JY
authors: Shey
authors: C M
authors: CM
authors: Sun
mesh_terms: D000215:Acylation; D010879:Piperazines / Q000138:chemical synthesis*; D013057:Spectrum Analysis
chemical_list: D010879:Piperazines