[Use of laser-doppler perfusion for evaluation of microcirculation in patients with diabetes type I].
The purpose of this study was to investigate the foot skin microcirculation in type 1-diabetic patients. The study group comprised 67 patients divided into four subgroups: 13 women and 11 men healthy and had no family history of diabetes; 19 women and 24 men had type 1-diabetes. The studied measurements included 7 parameters determined during rest and post occlusive hyperaemia. They were performed with laser Doppler fluxmetry using surface probe localised in distal part of the lower limbs. The most significant data localised the probe in thumb. The maximum of hyperaemic response (MAX) was significantly lower in the diabetic patients as compared to the healthy subjects (p < 0.01). The time of peak flow (TM) was higher (p < 0.01) in diabetic patients as compared to the control subjects. The half time of hyperaemia (TH) was significant longer (p < 0.05) for diabetic groups.


CONCLUSIONS
The laser Doppler method is helpful to identify patients with risk development diabetic complications. The most valuable data is MAX, TM and TH, the best localisation of the probe seems to be the most distal point of thumb.
Jasik
M
M
Katedra i Klinika Gastroeneterologii i Chorób Przemiany Materii A.M. w Warszawie.
Liebert
A
A
Juskowa
J
J
Karnafel
W
W
Maniewski
R
R
D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D017719:Diabetic Foot / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D005528:Foot / Q000098:blood supply; D006801:Humans; D006940:Hyperemia / Q000175:diagnosis / Q000503:physiopathology; D017078:Laser-Doppler Flowmetry; D008297:Male; D008833:Microcirculation; D012039:Regional Blood Flow; D012867:Skin / Q000098:blood supply*; D013933:Thumb / Q000098:blood supply