Effect of interferon beta on human myelin basic protein-specific T-cell lines: comparison of IFNbeta-1a and IFNbeta-1b.
The effect of interferon (IFN)beta-1a and IFNbeta-1b on human myelin basic protein-reactive T-cell lines was investigated. Both drugs inhibited proliferation and production of lymphotoxin (LT), whereas the production of interleukin-4 was not altered and interleukin-10 was induced. Comparing equal numbers of units IFNbeta-1a and -1b showed almost identical results. These in vitro data indicate that the immunomodulatory capacity of both interferons with respect to T cells paralleled their antiviral effect.
Weber
F
F
Department of Neurology, Georg-August-University of Göttingen, Germany.
Janovskaja
J
J
Polak
T
T
Poser
S
S
Rieckmann
P
P
D000704:Analysis of Variance; D002460:Cell Line / Q000187:drug effects / Q000276:immunology; D016207:Cytokines / Q000096:biosynthesis; D006801:Humans; D000068556:Interferon beta-1a; D000068576:Interferon beta-1b; D016899:Interferon-beta / Q000276:immunology* / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000276:immunology; D018448:Models, Immunological; D004676:Myelin Basic Protein / Q000187:drug effects*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
D016207:Cytokines; D004676:Myelin Basic Protein; D000068576:Interferon beta-1b; D016899:Interferon-beta; D000068556:Interferon beta-1a