No linkage of the lipoprotein lipase locus to hypertension in Caucasians.
OBJECTIVE
A previous study has shown significant linkage of five markers near the lipoprotein lipase locus to systolic blood pressure, but not to diastolic blood pressure, in nondiabetic members of 48 Taiwanese families selected for noninsulin-dependent diabetes. However, lipoprotein lipase markers did not appear strongly linked to systolic blood pressure in a study of Mexican-Americans using a variety of selection schemes. The objective of the current study was to test whether markers near the lipoprotein lipase gene were linked to hypertension in Caucasians.


METHODS
To test for linkage of genetic markers in or near the lipoprotein lipase gene to hypertension in Caucasians, two sets of Caucasian hypertensive sibships were genotyped. The samples included 261 sibships (431 effective sibpairs) from four field centers of the National Heart, Lung and Blood Institute Family Heart Study and 211 sibships (282 effective sibpairs) from the Health Family Tree database in Utah.


RESULTS
Two highly polymorphic markers in or near the lipoprotein lipase gene showed no evidence of excess allele sharing in either set of hypertensive sibships. Combining the two datasets resulted in 653 and 713 effective sibpairs for the two markers, sharing 0.495 +/- 0.30 and 0.486 +/- 0.28 alleles identical by descent compared to an expected sharing of 0.50. Multipoint analysis of the two loci also did not show linkage (P = 0.95).


CONCLUSIONS
We conclude that the lipoprotein lipase locus and nearby regions do not appear to be linked to hypertension in Caucasians.
Hunt
S C
SC
Department of Internal Medicine, University of Utah, Salt Lake City, USA. steve@ucvg.med.utah.edu
Province
M A
MA
Atwood
L D
LD
Sholinsky
P
P
Lalouel
J M
JM
Rao
D C
DC
Williams
R R
RR
Leppert
M F
MF
D000483:Alleles; D001794:Blood Pressure; D004247:DNA / Q000032:analysis; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000201:enzymology* / Q000235:genetics; D008071:Lipoprotein Lipase / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009679:Nuclear Family; D016133:Polymerase Chain Reaction; D014589:Utah; D044465:White People / Q000235:genetics*
D005819:Genetic Markers; D004247:DNA; D008071:Lipoprotein Lipase