title: Ultrastructural interactions in the microvasculature of human endometrial adenocarcinoma.
abstract: OBJECTIVE
  Our purpose was to study the ultrastructural morphology of the microvasculature of human endometrial adenocarcinoma and to determine the effect of this malignancy on cell-to-cell communication between the components of the microvasculature and with the other tissue compartments of human endometrium. Methods. Multiple cases of human endometrial adenocarcinoma were studied and graded by light microscopy. Six cases of Grade I and six cases of Grade II were selected. Two blocks per case were studied ultrastructurally.
  
  
  RESULTS
  In contrast to our expectation that the ultrastructure of tumor vessels would suggest a great deal of proliferation and new vessel formation, we found that tumor vessels displayed a high degree of cellular differentiation, in the form of numerous and varied cell-to-cell contacts, and large amounts of protein production.
  
  
  CONCLUSIONS
  The morphology of the microvasculature of endometrial adenocarcinoma suggests an active rather than passive role in tumor vessels.
authors: Department of Obstetrics and Gynecology, University of Kansas School of Medicine-Wichita, Wichita, Kansas, 62714, USA.
authors: D V
authors: DV
authors: Horbelt
authors: D K
authors: DK
authors: Roberts
authors: T H
authors: TH
authors: Parmley
authors: J E
authors: JE
authors: Delmore
authors: N J
authors: NJ
authors: Walker-Bupp
mesh_terms: D000230:Adenocarcinoma / Q000098:blood supply* / Q000648:ultrastructure*; D002450:Cell Communication; D016889:Endometrial Neoplasms / Q000098:blood supply* / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D008833:Microcirculation