Primary pulmonary collision tumor including squamous cell carcinoma and T-cell lymphoma.
We report a very rare occurrence of a primary collision tumor in the lung consisting of squamous cell carcinoma and T-cell lymphoma. A squamous cell carcinoma was diagnosed histologically following a transbronchial lung biopsy in a 71-year-old woman, but the other component was diagnosed histologically and immunohistochemically only on examination of the resection specimen. The malignant lymphoma was stained by the monoclonal antibody UCHL-1 (anti-D45RO) against T-lymphocytes but was not stained by the L26 (anti-CD20) antibody against B-lymphocytes. Immunostaining for CD3 was positive, confirming a T-cell lineage. Despite systemic chemotherapy, the patient died 7 months after operation, from progression of the lymphoma. Our case, which illustrates interesting attributes of collision tumors, consisted of an ordinary squamous cell carcinoma and a rare T-cell lymphoma arising in the lung, with the latter part of the combination dictating subsequent treatment and outcome.
Kawashima
O
O
Department of Surgery, National Sanatorium Nishigunma Hospital, Gumma, Japan.
Sakata
S
S
Kamiyoshihara
M
M
Maeshima
A
A
Ishikawa
S
S
Morishita
Y
Y
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor; D001706:Biopsy; D001999:Bronchoscopy; D017252:CD3 Complex / Q000276:immunology; D002294:Carcinoma, Squamous Cell / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008175:Lung Neoplasms / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D016399:Lymphoma, T-Cell / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D009378:Neoplasms, Multiple Primary / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D011013:Pneumonectomy; D013601:T-Lymphocytes / Q000276:immunology
D014408:Biomarkers, Tumor; D017252:CD3 Complex