Paralytic poliomyelitis associated with live oral poliomyelitis vaccine in child with HIV infection in Zimbabwe: case report.
OBJECTIVE
To describe a complication of oral vaccination with live, attenuated poliomyelitis virus in a child infected with HIV.


METHODS
Case report.


METHODS
Teaching hospital in Harare, Zimbabwe.


METHODS
A boy of 41/2 years and his mother.


METHODS
Results of clinical and laboratory investigations.


RESULTS
Two weeks after receiving the second dose of oral poliomyelitis vaccine during national immunisation days the child developed paralysis of the right leg. He had a high titre of antibodies against poliovirus type 2, as well as antibodies against HIV-1, a low CD4 count, a ratio of CD4 to CD8 count of 0.47, and hypergammaglobulinaemia. He did not have any antibodies against diphtheria, tetanus, or poliovirus types 1 and 3, although he had been given diphtheria, tetanus, and pertussis and oral polio vaccines during his first year and a booster of the diphtheria, tetanus, and pertussis vaccine at 24 months. He had no clinical symptoms of AIDS, but his mother had AIDS and tuberculosis.


CONCLUSIONS
Paralytic poliomyelitis in this child with HIV infection was caused by poliovirus type 2 after oral poliomyelitis vaccine.
Chitsike
I
I
Departments of Paediatrics and Immunology, Medical School of the University of Zimbabwe, PO Box A 178, Harare, Zimbabwe.
van Furth
R
R
D017088:AIDS-Related Opportunistic Infections / Q000150:complications*; D000284:Administration, Oral; D002675:Child, Preschool; D006801:Humans; D008297:Male; D011051:Poliomyelitis / Q000209:etiology*; D011054:Poliovirus Vaccine, Inactivated / Q000009:adverse effects*; D015030:Zimbabwe
D011054:Poliovirus Vaccine, Inactivated