title: New lead compounds for brassinosteroid biosynthesis inhibitors.
abstract: The first brassinosteroid biosynthesis inhibitor is reported. Among newly synthesized triazole derivatives, 4-(4-chlorophenyl)-2-phenyl-3-(1,2,4-triazoyl)butan-2-ol (6) was found to inhibit the growth of cress seedlings, and this inhibition was recovered by the treatment of brassinolide, suggesting that compound 6 primarily inhibits brassinosteroid biosynthesis.
authors: The Institute of Physical and Chemical Research (RIKEN), Wako, Saitama, Japan.
authors: Y K
authors: YK
authors: Min
authors: T
authors: T
authors: Asami
authors: S
authors: S
authors: Fujioka
authors: N
authors: N
authors: Murofushi
authors: I
authors: I
authors: Yamaguchi
authors: S
authors: S
authors: Yoshida
mesh_terms: D000440:Butanols / Q000737:chemistry / Q000494:pharmacology*; D012275:Oryza / Q000187:drug effects / Q000254:growth & development; D010937:Plant Growth Regulators / Q000037:antagonists & inhibitors* / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology*; D013256:Steroids / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D014230:Triazoles / Q000737:chemistry / Q000494:pharmacology*
chemical_list: C118931:4-(4-chlorophenyl)-2-phenyl-3-(1,2,4-triazol-1-yl)butan-2-ol; D000440:Butanols; D010937:Plant Growth Regulators; D013256:Steroids; D014230:Triazoles