Stereoselective synthesis of novel cyclopropyl analogues of known cysteine protease inhibitors.
Efficient synthesis of two novel analogues of some known protease inhibitors, via the isosteric replacement of oxirane/aziridine moiety of the parent compounds by cyclopropane ring, is described.
Kumar
J S
JS
Organic III, Indian Institute of Chemical Technology, Hyderabad.
Roy
S
S
Datta
A
A
D001388:Aziridines / Q000737:chemistry; D015853:Cysteine Proteinase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry*; D005027:Ethylene Oxide / Q000737:chemistry; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D001388:Aziridines; D015853:Cysteine Proteinase Inhibitors; C033132:aziridine; D005027:Ethylene Oxide