title: Risk factors for tuberculosis in patients with AIDS in London: a case-control study.
abstract: OBJECTIVE
  To identify risk factors for the acquired immune-deficiency syndrome (AIDS) associated with tuberculosis, in patients with AIDS attending 11 of the largest human immunodeficiency virus (HIV)/AIDS Units in London.
  
  
  METHODS
  Case-control study nested in a retrospective cohort of 2048 HIV-1 positive patients. Cases were defined as patients with a definitive diagnosis of tuberculosis, and controls as patients with AIDS and without tuberculosis during follow-up.
  
  
  RESULTS
  Of 627 patients diagnosed with AIDS, 121 had a definitive diagnosis of tuberculosis. Significant risk factors for tuberculosis in the univariate analysis were sex, ethnicity, age, HIV exposure category and hospital attended, and in the multiple regression analysis ethnicity, age and hospital attended. African ethnicity was the strongest risk factor for tuberculosis (adjusted odds ratio [AOR] 5.9, 95% confidence interval 3.4-10.2). The risk of tuberculosis was higher in the younger age groups (test for trend P < 0.001). The hospital-associated risk of tuberculosis was more heterogeneous in the non-African group, and non-Africans attending Hospital 1 had an increased risk of tuberculosis which was statistically significant.
  
  
  CONCLUSIONS
  The risk factors for AIDS-associated tuberculosis in London are sub-Saharan African origin, younger age group, and, among the non-Africans only, attending one hospital in east London. Different transmission patterns and mechanisms for the development of tuberculosis may operate in different settings depending on the background risk of tuberculous infection. Screening for tuberculosis infection and disease among HIV-positive individuals in London is important for the provision of preventive or curative therapy, and prophylaxis policies need to be designed in accordance with the transmission patterns and mechanisms of disease.
authors: MRC UK Centre for Co-ordinating Epidemiological Studies of HIV and AIDS, Department of STD, Mortimer Market Centre, London, UK. jdelamo@isciii.es
authors: J
authors: J
authors: Del Amo
authors: A
authors: A
authors: Petruckevitch
authors: A N
authors: AN
authors: Phillips
authors: K M
authors: KM
authors: De Cock
authors: J
authors: J
authors: Stephenson
authors: N
authors: N
authors: Desmond
authors: T
authors: T
authors: Hanscheid
authors: N
authors: N
authors: Low
authors: A
authors: A
authors: Newell
authors: A
authors: A
authors: Obasi
authors: K
authors: K
authors: Paine
authors: A
authors: A
authors: Pym
authors: C
authors: C
authors: Theodore
authors: A M
authors: AM
authors: Johnson
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology*; D000349:Africa / Q000208:ethnology; D016022:Case-Control Studies; D006801:Humans; D008131:London / Q000453:epidemiology; D016017:Odds Ratio; D012307:Risk Factors; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology*