The pharmacology of apoptosis.
Apoptosis is an area of intense scientific interest, which encompasses the study of and triggers mechanisms involved in mediating the cell biology of programmed cell death. A number of low molecular weight compounds have been used to inhibit or enhance this fundamental cellular process and so apoptosis has now become amenable to pharmacological manipulation. In this review Ross Kinloch, Mark Treherne, Mike Furness and Iradj Hajimohamadreza will focus on the current literature describing the pharmacology of apoptosis, with particular reference to the therapeutic potential that could arise from the development of pro- and anti-apoptotic drugs. The pivotal role of apoptosis in such diverse pathological processes as tumour growth, the immune response and neurodegeneration suggests that an understanding of how apoptosis can be regulated by drugs will become increasingly important to the pharmaceutical industry.
Kinloch
R A
RA
Department of Discovery Biology, Pfizer Central Research, Sandwich, UK.
Treherne
J M
JM
Furness
L M
LM
Hajimohamadreza
I
I
D000818:Animals; D017209:Apoptosis / Q000187:drug effects* / Q000502:physiology; D006801:Humans