Growth factors: biological and clinical aspects.
OBJECTIVE
The purpose of this meeting summary is to provide an overview of cytokine research and its role in radiation oncology.


METHODS
The sixth annual Radiation Workshop was held at the International Festival Institute at Round Top, TX.


RESULTS
Presentations of seventeen speakers provided the framework for discussions on the biological and clinical aspects of cytokine research.


CONCLUSIONS
Orchestration of coordinated cellular responses over the time course of radiation effects requires the interaction of many growth factors with their receptors as well as cell-cell and cell-matrix interactions. Cytokine networks and integrated systems are important in tumor development, cancer treatment, and normal and tumor response to cancer treatment.
Ruifrok
A C
AC
M. D. Anderson Cancer Center, Department of Biomathematics, Houston, TX 77030, USA.
McBride
W H
WH
D000818:Animals; D002450:Cell Communication; D002455:Cell Division; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D005355:Fibrosis; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D051379:Mice; D011832:Radiation Injuries / Q000378:metabolism* / Q000503:physiopathology; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D017978:Receptors, Growth Factor / Q000502:physiology*; D012106:Research; D016212:Transforming Growth Factor beta / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology; D014945:Wound Healing
D016326:Extracellular Matrix Proteins; D006133:Growth Substances; D018719:Erb-b2 Receptor Tyrosine Kinases; D017978:Receptors, Growth Factor; D016212:Transforming Growth Factor beta; D014409:Tumor Necrosis Factor-alpha