title: Sialidase inhibitors related to zanamivir: synthesis and biological evaluation of 4H-pyran 6-ether and ketone.
abstract: Synthesis of 5R-Acetamido-4S-amino-4H-pyran-6R-O-( -ethyl)propyl and 6R-(1-oxo-2-ethyl)butyl 2-carboxylic acids (4 and 5) and their evaluation as inhibitors of influenza virus sialidase is described. Both compounds showed good inhibitory activity with marked selectivity for influenza A sialidase.
authors: Department of Medicinal Chemistry, GlaxoWellcome Medicines Research Centre, Stevenage, Herts UK. PS5776@GGR.CO.UK
authors: P W
authors: PW
authors: Smith
authors: J E
authors: JE
authors: Robinson
authors: D N
authors: DN
authors: Evans
authors: S L
authors: SL
authors: Sollis
authors: P D
authors: PD
authors: Howes
authors: N
authors: N
authors: Trivedi
authors: R C
authors: RC
authors: Bethell
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006146:Guanidines; D007659:Ketones / Q000737:chemistry / Q000494:pharmacology*; D009439:Neuraminidase / Q000037:antagonists & inhibitors*; D011714:Pyrans / Q000737:chemistry / Q000494:pharmacology*; D012794:Sialic Acids / Q000737:chemistry / Q000494:pharmacology*; D053243:Zanamivir
chemical_list: D004791:Enzyme Inhibitors; D006146:Guanidines; D007659:Ketones; D011714:Pyrans; D012794:Sialic Acids; D009439:Neuraminidase; D053243:Zanamivir