Age estimates of two common mutations causing factor XI deficiency: recent genetic drift is not necessary for elevated disease incidence among Ashkenazi Jews.
The type II and type III mutations at the FXI locus, which cause coagulation factor XI deficiency, have high frequencies in Jewish populations. The type III mutation is largely restricted to Ashkenazi Jews, but the type II mutation is observed at high frequency in both Ashkenazi and Iraqi Jews, suggesting the possibility that the mutation appeared before the separation of these communities. Here we report estimates of the ages of the type II and type III mutations, based on the observed distribution of allelic variants at a flanking microsatellite marker (D4S171). The results are consistent with a recent origin for the type III mutation but suggest that the type II mutation appeared >120 generations ago. This finding demonstrates that the high frequency of the type II mutation among Jews is independent of the demographic upheavals among Ashkenazi Jews in the 16th and 17th centuries.
Goldstein
D B
DB
Galton Laboratory, Department of Biology, University College London, Wolfson House, London NW1 2HE, United Kingdom. d.goldstein@ucl.ac.uk
Reich
D E
DE
Bradman
N
N
Usher
S
S
Seligsohn
U
U
Peretz
H
H
D000483:Alleles; D002877:Chromosomes, Human / Q000235:genetics; D005173:Factor XI Deficiency / Q000453:epidemiology* / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics; D006801:Humans; D015994:Incidence; D007493:Iraq; D007585:Jews / Q000235:genetics*; D015810:Linkage Disequilibrium / Q000235:genetics; D008390:Markov Chains; D018895:Microsatellite Repeats / Q000235:genetics; D008957:Models, Genetic; D009154:Mutation / Q000235:genetics*; D011995:Recombination, Genetic / Q000235:genetics; D013997:Time Factors