[Autoantibodies to the thrombocytes and erythrocytes in HIV-infected patients].
In 48 patients with HIV infection were tested for the presence of autologous and allogenic antibodies to red blood cells with the use of Coombs' direct and indirect tests. 18 HIV-infected patients had IgG antibodies to thrombocytes, circulating in the blood (detected by the method of EIA) and bound to thrombocytes (detected by the method of RIA). In 5 out of 48 patients Coombs' direct test yielded positive results with red blood cells. 6 out of 18 examined patients had an elevated content of thrombocyte-bound antibodies. The presence of cross reactions between gp120 of human immunodeficiency virus and gp3a thrombocytes led to the formation of antithrombocyte antibodies and, consequently, to a decrease in the number of thrombocytes.
Kravchenko
A V
AV
Central Research Institute of Epidemiology, Hematological Research Center, Moscow, Russia.
Poliakova
A M
AM
Khasbekova
S G
SG
Donskov
S I
SI
Astrina
O S
OS
Maleev
V V
VV
D001323:Autoantibodies / Q000097:blood*; D001792:Blood Platelets / Q000276:immunology*; D004906:Erythrocyte Count; D004912:Erythrocytes / Q000276:immunology*; D015658:HIV Infections / Q000097:blood*; D015497:HIV-1; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D010976:Platelet Count
D001323:Autoantibodies; D007074:Immunoglobulin G