title: International economic analysis of primary prevention of cardiovascular disease with pravastatin in WOSCOPS. West of Scotland Coronary Prevention Study.
abstract: OBJECTIVE
  The results of the West of Scotland Coronary Prevention Study (WOSCOPS) demonstrated the clinical benefit of using pravastatin for the primary prevention of cardiovascular disease in hypercholesterolaemic men. To inform decision makers, who must also consider costs, this study assesses the economic efficiency of such an intervention in a broad range of countries.
  
  
  RESULTS
  A generalized model of cardiovascular disease prevention was used to estimate the cost-effectiveness of primary prevention with pravastatin compared to diet alone. This model follows a cohort of hypercholesterolaemic men over a given period quantifying the effect in terms of the avoidance of cardiovascular disease based on treatment-specific risks derived from WOSCOPS data and extensive record-linkage data on disease-specific survival. Country-specific costs are accounted for by expressing all such parameters in terms of the ratio of monthly treatment to that of managing a myocardial infarction. Over a broad range of inputs the cost-effectiveness ratios remain below $25,000 per life years gained, regardless of country. Subgroups with even better economic efficacy can be defined on the basis of higher baseline risk.
  
  
  CONCLUSIONS
  In contrast to some previous reports, this analysis based on trial data demonstrates that pravastatin provides not only an effective means of primary cardiovascular disease prevention, but also an efficient one.
authors: J
authors: J
authors: Caro
authors: W
authors: W
authors: Klittich
authors: A
authors: A
authors: McGuire
authors: I
authors: I
authors: Ford
authors: D
authors: D
authors: Pettitt
authors: J
authors: J
authors: Norrie
authors: J
authors: J
authors: Shepherd
mesh_terms: D000368:Aged; D000924:Anticholesteremic Agents / Q000008:administration & dosage / Q000191:economics*; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000191:economics* / Q000517:prevention & control*; D003365:Costs and Cost Analysis; D017048:Health Care Costs; D006801:Humans; D007391:International Cooperation; D008297:Male; D008875:Middle Aged; D018803:Models, Economic; D017035:Pravastatin / Q000008:administration & dosage / Q000191:economics*; D011322:Primary Prevention / Q000191:economics* / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D006113:United Kingdom
chemical_list: D000924:Anticholesteremic Agents; D017035:Pravastatin