title: Frequency of invasive cancer in surgically excised vulvar lesions with intraepithelial neoplasia (VIN 3).
abstract: OBJECTIVE
  The aim of this study was to determine the frequency of invasive cancer found from specimens removed by surgical excision on patients with diagnosis of VIN 3.
  
  
  METHODS
  Seventy-eight patients with biopsy-proven vulvar intraepithelial neoplasia 3 (VIN 3) were treated by surgical excision.
  
  
  RESULTS
  Sixteen patients (20.5%) were found to have invasion in the excised surgical specimen. Superficial invasion was seen in 7 patients (9%), 9 were noted to have >1 mm invasion (11.5%), and 1 patient had in situ Paget's disease (1.3%).
  
  
  CONCLUSIONS
  Surgical excision should be considered a preferable method in management of patients with VIN 3.
authors: Division of Gynecologic Oncology, University of Cincinnati College of Medicine, Cincinnati, Ohio, 45267-0526, USA.
authors: N
authors: N
authors: Husseinzadeh
authors: C
authors: C
authors: Recinto
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002278:Carcinoma in Situ / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D014846:Vulvar Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery