title: Solution-phase simultaneous addition of functionalities (SPSAF) and chemical transformation to prepare N,N'-disubstituted piperazine libraries.
abstract: Several piperazine libraries were prepared using solution phase simultaneous addition of functionalities methodology as well as the "library from library" concept. The resulting piperazine libraries displayed antimicrobial activity against both gram-positive and gram-negative bacteria.
authors: Isis Pharmaceuticals, Inc., 2292 Faraday Avenue, Calsbad, California 92008, USA.
authors: P P
authors: PP
authors: Kung
authors: P D
authors: PD
authors: Cook
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis; D001894:Borohydrides / Q000737:chemistry; D004926:Escherichia coli / Q000187:drug effects; D013058:Mass Spectrometry; D019151:Peptide Library; D000077489:Piperazine; D010879:Piperazines / Q000737:chemistry* / Q000494:pharmacology; D013297:Streptococcus pyogenes / Q000187:drug effects; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D000900:Anti-Bacterial Agents; D001894:Borohydrides; D019151:Peptide Library; D010879:Piperazines; D000077489:Piperazine; C024731:diborane