title: Preproenkephalin mRNA and enkephalin levels in the adult Syrian hamster: the influence from glucocorticoids.
abstract: Proenkephalin (Penk) gene structure in hamsters and humans are similar but they differ from rats. In this study hamster Penk gene expression was examined after hypophysectomy+/-glucocorticoid receptor blockade with RU 486 (mifepristone). In contrast to rats, basal Penk gene expression in hamster adrenals did not change after treatments that reduced both the influence from glucocorticoids and phenylethanolamine-N-methyltransferase mRNA levels. Meanwhile, striatal preproenkephalin mRNA levels increased under these conditions.
authors: Department of Pharmacology, Cornell University Medical College, 1300 York Avenue, New York, NY 10021, USA.
authors: R
authors: R
authors: Jimenez
authors: B C
authors: BC
authors: Yoburn
authors: S E
authors: SE
authors: Calvano
authors: S O
authors: SO
authors: Franklin
mesh_terms: D000311:Adrenal Glands / Q000737:chemistry / Q000502:physiology; D000367:Age Factors; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects* / Q000235:genetics; D003342:Corpus Striatum / Q000737:chemistry / Q000502:physiology; D006224:Cricetinae; D004745:Enkephalins / Q000235:genetics*; D015870:Gene Expression / Q000187:drug effects / Q000502:physiology; D005938:Glucocorticoids / Q000494:pharmacology*; D006727:Hormone Antagonists / Q000494:pharmacology; D007016:Hypophysectomy; D008297:Male; D008647:Mesocricetus; D015735:Mifepristone / Q000494:pharmacology; D011498:Protein Precursors / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats
chemical_list: D004745:Enkephalins; D005938:Glucocorticoids; D006727:Hormone Antagonists; D011498:Protein Precursors; D012333:RNA, Messenger; D015735:Mifepristone; C033660:preproenkephalin