Potential tissue selectivity of dietary phytoestrogens and estrogens.
The recent discovery of a second estrogen receptor subtype, estrogen receptor-beta, may significantly advance our understanding of tissue specific effects of estrogenic compounds, both natural and synthetic. Although specific effects mediated by estrogen receptor beta in vivo remain to be elucidated, hypothetically the existence of two estrogen receptor subtypes (differing in both tissue distribution and biological activity) may help to explain the curious pharmacological behaviour of many estrogenic and antiestrogenic compounds, including the naturally occurring dietary phytoestrogens.
Cassidy
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Centre for Nutrition and Food Safety, School of Biological Sciences, University of Surrey, Guildford, UK.
D000818:Animals; D004032:Diet; D047629:Estrogen Receptor beta; D004967:Estrogens / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics*; D004968:Estrogens, Non-Steroidal / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics*; D006801:Humans; D007529:Isoflavones; D015394:Molecular Structure; D048789:Phytoestrogens; D028321:Plant Preparations; D011960:Receptors, Estrogen / Q000378:metabolism
D047629:Estrogen Receptor beta; D004967:Estrogens; D004968:Estrogens, Non-Steroidal; D007529:Isoflavones; D048789:Phytoestrogens; D028321:Plant Preparations; D011960:Receptors, Estrogen