The protective effect of Ginkgo biloba extract on CCl4-induced hepatic damage.
The aim of this study was to evaluate the protective effect of Ginkgo biloba extract on CCl4-induced hepatic damage in rats. Hepatic malondialdehyde, glutathione and hydroxyproline levels and histopathologic alterations in liver specimens were assessed. 200 mg/kg/day Ginkgo biloba extract were given orally to the animals for 10 days, then a single dose of 2 ml/kg b.w. carbon tetrachloride was, administered intraperitoneally. Ginkgo biloba extract treatment reduced hepatic malondialdehyde levels significantly (p < 0.05), but did not alter glutathione (p > 0.05) and hydroxyproline levels (p > 0.05). The light and electron microscopic findings showed that Ginkgo biloba extract limited the CCl4-induced hepatocyte necrosis and atrophy. These results suggest that this extract may protect the hepatocytes from carbon tetrachloride-induced liver injury.
Ozenirler
S
S
Department of Gastroenterology, Gazi University Faculty of Medicine, Beşevler, Ankara, Turkey.
Dinçer
S
S
Akyol
G
G
Ozoğul
C
C
Oz
E
E
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001284:Atrophy; D002251:Carbon Tetrachloride / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D020441:Ginkgo biloba; D005978:Glutathione / Q000378:metabolism; D006909:Hydroxyproline / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000293:injuries* / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008854:Microscopy, Electron; D009336:Necrosis; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D010936:Plant Extracts; D008315:Malondialdehyde; D002251:Carbon Tetrachloride; D005978:Glutathione; D006909:Hydroxyproline