title: Expression of GABA transaminase immunoreactivity in interneurons of the rat neostriatum.
abstract: Immunoreactivity for gamma-aminobutyric acid transaminase (GABA-T), a degradation enzyme for GABA, was localized by immunocytochemistry in the rat neostriatum and the globus pallidus using a monoclonal antibody. Immunoreactivity for GABA-T was found primarily in interneurons and in the neuropilar elements in the neostriatum. Many of GABA-T-immunoreactive neurons were found to display parvalbumin immunoreactivity. This indicates many of the GABA-T-immunoreactive neurons are striatal GABAergic interneurons. Occasionally, GABA-T-immunoreactive glial cells were found. In the globus pallidus, many pallidal neurons also displayed GABA-T immunoreactivity and many of the immunoreactive neurons were seen to express parvalbumin immunoreactivity. Immunoreactivity for GABA-T was also detected in the neuropil of the globus pallidus. The present results indicate the GABAergic interneurons in the neostriatum and a subpopulation of pallidal neurons play an important role in metabolic degradation of GABA in the basal ganglia.
authors: Department of Biology, Hong Kong Baptist University, Kowloon Tong. kklyung@hkbu.edu.hk
authors: K K
authors: KK
authors: Yung
authors: K H
authors: KH
authors: Kwok
authors: Z G
authors: ZG
authors: Gao
authors: S Y
authors: SY
authors: Choi
authors: F S
authors: FS
authors: Kwok
mesh_terms: D000612:4-Aminobutyrate Transaminase / Q000378:metabolism*; D000818:Animals; D005455:Fluorescent Antibody Technique; D007395:Interneurons / Q000201:enzymology*; D017072:Neostriatum / Q000166:cytology / Q000201:enzymology*; D051381:Rats
chemical_list: D000612:4-Aminobutyrate Transaminase