Serum levels of soluble Fas and disease activity in patients with IgA nephropathy.
Using a sandwich ELISA, we studied 48 patients with IgA nephropathy and 10 patients with diffuse mesangial proliferative glomerulonephritis without IgA deposition (non-IgA PGN) to determine if levels of serum soluble Fas (s-Fas) might reflect the disease activity. The levels of serum s-Fas in patients with the advanced stage of IgA nephropathy were significantly higher than those in patients with the mild stage of the disease, in non-IgA PGN or in healthy controls. The results showed that advanced stage IgA nephropathy patients who showed heavy proteinuria and the presence of urinary casts revealed high levels of serum s-Fas. It was thus suggested that the measurement of serum s-Fas is useful in evaluating the degree of renal injury in patients with IgA nephropathy.
Shou
I
I
Division of Nephrology, Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan.
Tashiro
K
K
Kurusu
A
A
Kaneko
S
S
Hayashi
T
T
Fukui
M
M
Shirato
I
I
Kubota
K
K
Tomino
Y
Y
D000293:Adolescent; D000328:Adult; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005922:Glomerulonephritis, IGA / Q000097:blood* / Q000276:immunology / Q000473:pathology; D015432:Glomerulonephritis, Membranoproliferative / Q000097:blood / Q000276:immunology / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology; D008297:Male; D008875:Middle Aged; D019014:fas Receptor / Q000097:blood* / Q000276:immunology
D019014:fas Receptor; D003404:Creatinine