title: Synthesis, characterization, and biodistribution of oxo complexes of technetium-99m with biguanide and N1-substituted ligands.
abstract: We report the synthesis, characterization, and biodistribution of 99mTc-complexes with the bidentate-N,N chelate biguanide (Big) and the N1-substituted ligands dimethyl (DMBig), phenyl (PBig), and phenethyl (PEBig). Dynamic gamma-camera studies with 99mTc-Big and 99mTc-DMSA in rabbits indicated distinct renal and urinary excretion profiles. 99mTc-Big was cleared more quickly than 99mTc-DMSA, and for the same acquisition times, the contrast in whole-body images favored 99mTc-Big. Also, the estimated radiation absorbed doses by kidneys and blood for 99mTc-DMSA were significantly higher than for 99mTc-Big. These preliminary studies show that 99mTc-Big has favourable practical and dosimetric features for renal imaging as an alternative to 99mTc-DMSA.
authors: Departamento de Química, Instituto Tecnológico e Nuclear, Sacavém, Portugal. mneves@itn1.itn.pt
authors: M
authors: M
authors: Neves
authors: L
authors: L
authors: Gano
authors: M J
authors: MJ
authors: Ribeiro
authors: A C
authors: AC
authors: Santos
authors: A
authors: A
authors: Marchi
authors: C
authors: C
authors: Sawas-Dimopolou
authors: J J
authors: JJ
authors: Pedroso de Lima
mesh_terms: D000818:Animals; D001645:Biguanides / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D005260:Female; D007668:Kidney / Q000000981:diagnostic imaging*; D051379:Mice; D015609:Organotechnetium Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D011485:Protein Binding; D011817:Rabbits; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar; D019783:Technetium Tc 99m Dimercaptosuccinic Acid / Q000493:pharmacokinetics; D014915:Whole-Body Counting
chemical_list: D001645:Biguanides; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D019783:Technetium Tc 99m Dimercaptosuccinic Acid