The PABA story.
The qualities of para-aminobenzoic acid (PABA) are discussed and an account is given of how it came to be the favourite sunscreen of the post World War II era. Slowly, however, dermatologists became aware that it was a fairly common sensitizer and that it tended to cross-sensitize with compounds of similar chemical structure both in contact with the skin and given as systemic drugs. Furthermore, continued exposure to chemicals of this type could lead to autoimmune responses especially systemic lupus erythematosus and dermatomyositis. Discussion of these complications from the use of PABA took place at two meetings of the Dermatological Association of Australia in 1964 and 1965, and played a part in the slow withdrawal of PABA from sunscreens.
Mackie
B S
BS
Prince Henry Hospital, Sydney, Australia.
Mackie
L E
LE
D010129:4-Aminobenzoic Acid / Q000009:adverse effects / Q000266:history*; D001315:Australia; D003875:Drug Eruptions / Q000209:etiology / Q000266:history; D049673:History, 20th Century; D006801:Humans; D013473:Sunscreening Agents / Q000009:adverse effects / Q000266:history*
D013473:Sunscreening Agents; D010129:4-Aminobenzoic Acid