Immunohistochemical examination of NOS and SOD in nasal mucosa.
An immunohistochemical examination was performed to detect the localization of neural-type nitric oxide synthase (nNOS), endothelial-type NOS (eNOS) and inducible-type NOS (iNOS) in the human and mouse nasal mucosa. nNOS-immunoreactive nerve fibers were found in the subepithelial layer and around the seromucous glands of mice. In these fibers, immunodouble staining revealed co-localization of nNOS and superoxide dismutase (SOD). In the human nasal mucosa of normal subjects, strong eNOS immunoreactivity and weak iNOS immunoreactivity were found in the columnar epithelium.
Sawada
T
T
Department of Otolaryngology, Fujita Health University, Second Affiliated Hospital Nagoya, Aichi, Japan.
Nishimura
T
T
Saki
M
M
Nagatsu
I
I
D000818:Animals; D006801:Humans; D007124:Immunoenzyme Techniques; D051379:Mice; D009297:Nasal Mucosa / Q000201:enzymology*; D019001:Nitric Oxide Synthase / Q000032:analysis*; D013482:Superoxide Dismutase / Q000032:analysis*
D019001:Nitric Oxide Synthase; D013482:Superoxide Dismutase