[The characteristics of the course of Leishmania and Pneumocystis opportunistic infections in immunosuppressed laboratory animals].
Specific features of the course of Leishmania and Pneumocystis infections were studied on experimental models. Laboratory animals were subjected to medicinal suppression with Tricort-40. Leishmania infection in naturally susceptible animals was considerably aggravated (in comparison with the controls) in the presence of even short-term immunosuppression. Pneumocystis infection developed in experimental animals under the effect of double suppression. The process of the reactivation of Pneumocystis infection was influenced by Leishmania infection, rapidly developing in the presence of prolonged immunodeficiency. The results thus obtained make it possible to regard Leishmania infection in animals with reactivated Pneumocystis infection as co-infection having the properties of a biological, immunosuppressant. Such situation may be extrapolated on HIV/visceral leishmaniasis co-infection.
Lysenko
A Ia
AIa
Medical Academy of Post-Graduate Education, Moscow, Russia.
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis*; D000818:Animals; D006224:Cricetinae; D015497:HIV-1; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000494:pharmacology; D018314:Leishmania infantum; D007898:Leishmaniasis, Visceral / Q000175:diagnosis*; D008647:Mesocricetus; D016720:Pneumocystis Infections / Q000175:diagnosis*; D051381:Rats; D017208:Rats, Wistar; D016205:Sigmodontinae; D014222:Triamcinolone Acetonide / Q000494:pharmacology
D007166:Immunosuppressive Agents; D014222:Triamcinolone Acetonide