Can growth hormone counteract the effects of glucocorticoids on protein metabolism?
The size of the body's protein pool depends on the equilibrium between protein synthesis and breakdown. Glucocorticoids, the most potent catabolic hormones, act primarily by increasing protein breakdown, both in muscle and at the whole-body level. Growth hormone (GH) counteracts the catabolic effects of glucocorticoids by stimulating protein synthesis. Part of its effects are mediated via insulin-like growth factor I (IGF-I). The effects of combined GH-IGF-I treatment are discussed.
Beaufrère
B
B
Laboratory of Human Nutrition, Human Nutrition Research Centre, Clermont-Ferrand, France.
D000818:Animals; D002986:Clinical Trials as Topic; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D019382:Human Growth Hormone / Q000008:administration & dosage*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000008:administration & dosage*; D008297:Male; D011506:Proteins / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D016896:Treatment Outcome
D005938:Glucocorticoids; D011506:Proteins; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I