[Intestinal complications of thrombotic microangiopathy in the adult. 4 cases and review of the literature].
We report four cases of adult thrombotic microangiopathy associating diarrhea with severe ischemic colitis. In one case, the intestinal complications was severe and diffuse ischemic colitis, in two cases an inaugural colonic perforation requiring colectomy and in the last case a massive mesenteric infarct. In three cases, histologic examination showed vessel occlusion with microthrombi. Despite treatment with plasma exchange and plasma infusion, death ensued in two cases. Principally described in childhood thrombotic microangiopathy, intestinal complications occur exceptionally in adult thrombotic microangiopathy and are associated with a poor prognosis. Inaugural ischemic colitis revealing an adult thrombotic microangiopathy is also uncommon and thrombotic microangiopathy could be evoked in all patients presenting acute ischemic colitis.
Klisnick
A
A
Service de Néphrologie et de Réanimation Médicale Polyvalente, Hôpital Gabriel-Montpied, Clermont-Ferrand.
Levannier
M
M
Soriano
C
C
Gazuy
N
N
Fourcade
J
J
Forestier
C
C
Souweine
B
B
Baguet
J C
JC
D058186:Acute Kidney Injury / Q000150:complications*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000743:Anemia, Hemolytic / Q000150:complications*; D017091:Colitis, Ischemic / Q000209:etiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D013921:Thrombocytopenia / Q000150:complications*