Ginkgo biloba extract (EGb 761) protects Na,K-ATPase activity during cerebral ischemia in mice.
Neuroprotective drugs such as Ginkgo biloba extract (EGb 761) could prevent the ischemia-induced impairment of the Na,K-ATPase activity. In this study, Na,K-ATPase activity and expression, contents in fatty acids and malondialdehyde, an index of lipoperoxidation, were compared in the ipsilateral (ischemic) and the contralateral (unlesioned) cortices after 1 h of unilateral focal cortices cerebral ischemia in the mouse. EGb 761 (110 mg/kg) was administered daily to half of the animals for 10 days before ischemia. Ischemia significantly reduced Na,K-ATPase activity by about 40% and increased malondialdehyde content; EGb 761 pretreatment abolished these effects. The free radical scavenger properties of EGb 761 are a potential mechanism by which Na,K-ATPase injury and lipoperoxidation are prevented.
Pierre
S
S
Laboratoire de Recherche Cardiologique, Université de la Méditerranée, Faculté de Médecine, I.F.R. Jean Roche, Marseille, France.
Jamme
I
I
Droy-Lefaix
M T
MT
Nouvelot
A
A
Maixent
J M
JM
D000818:Animals; D005227:Fatty Acids / Q000378:metabolism; D005419:Flavonoids / Q000627:therapeutic use*; D016166:Free Radical Scavengers / Q000627:therapeutic use; D020441:Ginkgo biloba; D002546:Ischemic Attack, Transient / Q000188:drug therapy*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D010936:Plant Extracts / Q000627:therapeutic use*; D010946:Plants, Medicinal; D000254:Sodium-Potassium-Exchanging ATPase / Q000187:drug effects*; D000096983:Ginkgo Extract
D005227:Fatty Acids; D005419:Flavonoids; D016166:Free Radical Scavengers; D008315:Malondialdehyde; D018696:Neuroprotective Agents; D010936:Plant Extracts; D000254:Sodium-Potassium-Exchanging ATPase; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract