title: Micronucleus frequency in Gomel (Belarus) children affected and not affected by thyroid cancer.
abstract: Cytogenetic monitoring was carried out on a group of children from Gomel (Belarus), one of the areas most severely affected by radioactive contamination following the accident at the Chernobyl nuclear power plant, in 1986. We performed the micronucleus test (MN) in binucleated lymphocytes of 42 children (mean age: 11+/-2.34 years), 16 of whom were affected by thyroid gland tumor. Thirty healthy children living in Pisa (mean age: 14.96+/-2.17 years) were enrolled in the study as controls. Thyroid tumor affected children living in Gomel showed a statistically significant increase in the frequency of micronucleated cells as compared with the healthy children from Pisa. Moreover, a significant correlation was found between MN frequency and both the presence of tumor and higher 137Cs contamination. In addition, higher 137Cs contamination was more frequently observed in tumor affected children. These results suggest that the increased MN frequency is attributable more to 137Cs contamination rather than to the presence of the tumor itself.
authors: Dipartimento di Scienze dell'Uomo e dell'Ambiente, Via S. Giuseppe, 22 56100, University of Pisa, Pisa, Italy.
authors: L
authors: L
authors: Zotti-Martelli
authors: L
authors: L
authors: Migliore
authors: G
authors: G
authors: Panasiuk
authors: R
authors: R
authors: Barale
mesh_terms: D000293:Adolescent; D002648:Child; D002869:Chromosome Aberrations; D004273:DNA, Neoplasm / Q000528:radiation effects*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects*; D008297:Male; D048629:Micronuclei, Chromosome-Defective / Q000528:radiation effects*; D015162:Micronucleus Tests; D009381:Neoplasms, Radiation-Induced / Q000097:blood* / Q000235:genetics; D011210:Power Plants; D011839:Radiation, Ionizing; D011847:Radioactive Fallout; D018788:Radioactive Hazard Release; D002094:Republic of Belarus; D013964:Thyroid Neoplasms / Q000097:blood* / Q000235:genetics; D014455:Ukraine
chemical_list: D004273:DNA, Neoplasm; D011847:Radioactive Fallout