In vitro activities of ketolides HMR 3647 [correction of HRM 3647] and HMR 3004 [correction of HRM 3004], levofloxacin, and other quinolones and macrolides against Neisseria spp. and Moraxella catarrhalis.
In vitro activities of the ketolides HMR 3647 [corrected] and HMR 3004 [corrected] against pathogenic Neisseria gonorrhoeae and N. meningitidis, saprophytic Neisseria isolates, and Moraxella catarrhalis were determined. The comparison of ketolide activities with those of the other macrolides shows a much better activity in the majority of species, with macrolide MICs at which 90% of the isolates are inhibited between 8- and 10-fold higher.
Sáez-Nieto
J A
JA
Servicio de Bacteriología, Instituto de Salud Carlos III, Madrid, Spain. jasaez@isciii.es
Vázquez
J A
JA
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006801:Humans; D048628:Ketolides; D064704:Levofloxacin; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D001936:Moraxella catarrhalis / Q000187:drug effects*; D009343:Neisseria / Q000187:drug effects*; D015242:Ofloxacin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D048628:Ketolides; D018942:Macrolides; C105420:RU 64004; D064704:Levofloxacin; D015242:Ofloxacin; C106791:telithromycin