Sesquiterpene esters of aristolochic acid from the root and stem of Aristolochia heterophylla.
Three novel sesquiterpene esters of aristolochic acid, aristoloterpenate-II (2), -III (3), and-IV (4), together with known aristoloterpenate-I (1), were isolated and characterized from the root and stem of Aristolochia heterophylla. Their structures were elucidated by spectroscopic methods. The absolute configuration of these compounds at C-4' was determined as R by circular dichroic studies. These compounds showed cytotoxicity against hepatoma G2, 2, 2, 15 cells.
Wu
T S
TS
Department of Chemistry, National Cheng Kung University, Tainan, Taiwan 701, Republic of China. tswu@mail.ncku.edu.tw
Chan
Y Y
YY
Leu
Y L
YL
Chen
Z T
ZT
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D034341:Aristolochic Acids; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D008114:Liver Neoplasms, Experimental / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010616:Phenanthrenes / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D034341:Aristolochic Acids; D004365:Drugs, Chinese Herbal; D010616:Phenanthrenes; D012717:Sesquiterpenes; C000228:aristolochic acid I