Neuroinvasion by human herpesvirus type 7 in a case of exanthem subitum with severe neurologic manifestations.
A 19-month-old girl presented with severe neurologic symptoms associated with exanthem subitum. Human herpesvirus type 7 (HHV-7) DNA was detected in the CSF and serum, and supported by serologic studies. The patient was diagnosed with encephalopathy due to an acute HHV-7 infection. Neuron-specific enolase in the CSF was strongly elevated during the acute stage of infection, suggesting that the encephalopathy was due to viral invasion of the brain.
van den Berg
J S
JS
Department of Child Neurology, University Hospital Nijmegen, The Netherlands.
van Zeijl
J H
JH
Rotteveel
J J
JJ
Melchers
W J
WJ
Gabreëls
F J
FJ
Galama
J M
JM
D001927:Brain Diseases / Q000209:etiology / Q000821:virology*; D004279:DNA, Viral / Q000134:cerebrospinal fluid; D005260:Female; D006566:Herpesviridae Infections / Q000134:cerebrospinal fluid* / Q000150:complications; D016199:Herpesvirus 7, Human; D006801:Humans; D007223:Infant; D010751:Phosphopyruvate Hydratase / Q000134:cerebrospinal fluid; D016133:Polymerase Chain Reaction
D004279:DNA, Viral; D010751:Phosphopyruvate Hydratase