Diabetic alteration of cardiac vago-sympathetic modulation assessed with tone-entropy analysis.
No clear evidence of diabetic alteration of cardiac sympatho-vagal balance has been reported to date. We assessed heart rate variability of diabetic patients with the tone-entropy analysis that has been published elsewhere (Oida et al. 1997). Tone reflects the cardiac vago-sympathetic balance and entropy the total autonomic efferent activity. Diabetic influence on tone and entropy was examined in two groups of patients (38-52 years and 60-69 year, total 106) stratified according to the occurrence of impaired glucose tolerance or diabetes mellitus. Ten healthy middle-aged volunteers were also examined as a reference. Electrocardiographic data were collected at rest for 10 min. Tone increased and entropy decreased significantly with severity of diabetic disorders. The alterations were depicted as a curvi-linear relation in tone-entropy space, which superimposed adequately on the standard tone-entropy values obtained in a pharmacological experiment. The results demonstrate that the vago-sympathetic balance is altered with diabetic disorders: vagal predominance is impaired significantly in proportion to a withdrawal of total autonomic efferent activity.
Oida
E
E
Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto University, Japan.
Kannagi
T
T
Moritani
T
T
Yamori
Y
Y
D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology; D001285:Atropine; D001786:Blood Glucose / Q000378:metabolism; D002940:Circadian Rhythm; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000503:physiopathology*; D004562:Electrocardiography; D019277:Entropy; D005951:Glucose Tolerance Test; D006321:Heart / Q000294:innervation / Q000503:physiopathology*; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010276:Parasympatholytics; D011433:Propranolol; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000503:physiopathology*; D013565:Sympatholytics; D014630:Vagus Nerve / Q000187:drug effects / Q000503:physiopathology*
D001786:Blood Glucose; D010276:Parasympatholytics; D013565:Sympatholytics; D001285:Atropine; D011433:Propranolol