title: [Effects of argon gas embolism during pneumoperitoneum].
abstract: In a porcine model, ten animals with a mean body weight of 18.9 (15-24) kg were exposed either to intravenous boli of 10, 20, and 30 ml argon (n = 5) or CO2 gas (n = 5). Gas embolism with argon led to increased pulmonary artery pressure (P > 0.001) and induced a decrease in end tidal CO2 (P < 0.001) and reduced cardiac output (P < 0.001) with a consecutive decrease in mean arterial pressure (P < 0.05). One animal died in cardiac shock after a 20 ml argon gas embolism and another after a 30 ml argon bolus. A third animal recovered after resuscitation with noradrenaline after a 30 ml argon bolus. Animals in the CO2 group receiving 10, 20, or 30 ml bolus neither required resuscitation nor died. Hemodynamic parameters were not affected by a 10 to 30 ml bolus of CO2 gas. Thus, gases with a low solubility in blood like argon should not be used during procedures with an increased risk of gas embolism.
authors: Klinik für Allgemein-, Visceral-, Gefäss- und Thoraxchirurgie, Universitätsklinikum, Medizinische Fakultät der Humboldt-Universität zu Berlin.
authors: T
authors: T
authors: Junghans
authors: B
authors: B
authors: Böhm
authors: J
authors: J
authors: Neudecker
authors: U
authors: U
authors: Mansmann
authors: K
authors: K
authors: Gründel
mesh_terms: D000818:Animals; D001128:Argon; D004305:Dose-Response Relationship, Drug; D004618:Embolism, Air / Q000503:physiopathology*; D006439:Hemodynamics / Q000502:physiology; D007431:Intraoperative Complications / Q000503:physiopathology*; D011028:Pneumoperitoneum, Artificial; D011655:Pulmonary Embolism / Q000503:physiopathology*; D013552:Swine
chemical_list: D001128:Argon