title: The impact of propylthiouracil therapy on lipid peroxidation and antioxidant status parameters in hyperthyroid patients.
abstract: This study was performed on 17 hyperthyroid patients and 15 healthy controls. The patients were under propylthiouracil (PTU) therapy at a dosage of 3 x 100 mg/day for one month. Blood samples, taken at the beginning and on the 30th day of therapy, were analyzed for hormonal parameters (T3, T4, TSH), lipid peroxidation endproduct [thiobarbituric acid reactive substances (TBARS)] and antioxidant status parameters: glutathione (GSH), glutathione peroxidase (GSH-Px) and CuZn superoxide dismutase (CuZn SOD). Hyperthyroid patients were observed to have significantly higher TBARS, GSH and CuZn SOD levels than controls (P < 0.05, P < 0.001, P < 0.001, respectively). PTU therapy caused a relief in oxidative stress as reflected by significantly decreased TBARS levels (P < 0.001) and a selective modification in the antioxidant status parameters: significant decreases in GSH and CuZn SOD levels (P < 0.001) and a significant increase in GSH Px (P < 0.01) activity. Our findings suggest a selective modification of the antioxidative profile in hyperthyroidism. PTU should also be considered as an in vivo antioxidant, in addition to its antithyroid action.
authors: Department of Biochemistry, Cerrahpasa Medical Faculty, Istanbul University, Turkey.
authors: A
authors: A
authors: Seven
authors: E
authors: E
authors: Tasan
authors: H
authors: H
authors: Hatemi
authors: G
authors: G
authors: Burcak
mesh_terms: D000328:Adult; D013956:Antithyroid Agents / Q000627:therapeutic use*; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D005978:Glutathione / Q000097:blood*; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy* / Q000378:metabolism*; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010088:Oxidoreductases / Q000097:blood*; D011441:Propylthiouracil / Q000627:therapeutic use*; D012016:Reference Values; D013482:Superoxide Dismutase / Q000097:blood; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D013956:Antithyroid Agents; D008054:Lipid Peroxides; D017392:Thiobarbituric Acid Reactive Substances; D011441:Propylthiouracil; D010088:Oxidoreductases; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione