Small molecule cytokine mimetics.
A number of reports describe small peptides, and even bona fide small organic molecules, that activate homodimeric cytokine receptors and show cytokine-like activity in vitro and in vivo. These cases can be examined in light of the mechanistic and thermodynamic principles that govern cytokine-receptor activation.
Whitty
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Protein Engineering Department, Biogen, Inc., 14 Cambridge Center, Cambridge, MA 02142, USA. Adrian_Whitty@Biogen.com
Borysenko
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CW
D016207:Cytokines / Q000737:chemistry / Q000378:metabolism*; D019281:Dimerization; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006801:Humans; D018716:Molecular Mimicry; D010455:Peptides / Q000494:pharmacology; D018121:Receptors, Cytokine / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*
D016207:Cytokines; D010455:Peptides; D018121:Receptors, Cytokine