Control of cell proliferation by Myc family genes.
The c-myc proto-oncogene was discovered as the cellular homologue of the transforming oncogene of several chicken retroviruses. It has become clear that c-myc is a member of a small gene family; members of this family encode transcription factors of the Helix-loop-Helix family of transcription factors that can both activate and repress transcription. In vivo, these genes control both proliferation and apoptosis. This review will focus on recent progress in understanding how the encoded proteins exert their biological functions.
Eilers
M
M
Institute for Molecular Biology and Tumour Research, University of Marburg, Germany. eilers@imt.uni-marburg.de
D000818:Animals; D002455:Cell Division / Q000187:drug effects / Q000235:genetics*; D016259:Genes, myc / Q000502:physiology*; D006133:Growth Substances / Q000235:genetics* / Q000502:physiology*; D006801:Humans; D000090063:Proto-Oncogene Mas; D016271:Proto-Oncogene Proteins c-myc / Q000502:physiology
D006133:Growth Substances; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D016271:Proto-Oncogene Proteins c-myc