The use of fluconazole as a local irrigant for nephrostomy tubes.
OBJECTIVE
Few data exist concerning the combined use of fluconazole systemically and as an irrigant for nephrostomy tubes in a patient with renal candidiasis. The patient described here presented with renal fungal balls obstructing the drainage of urine from her nephrostomy tubes.


METHODS
Twelve months after chemoradiation for a stage IIB squamous cell carcinoma of the uterine cervix, a 35-year-old woman presented with renal obstruction necessitating insertion of ureteral stents. After 6 months of chemotherapy, the patient developed uremia. After nephrostomy tubes were placed, renal candidiasis was noted, and fluconazole was begun systemically. When the renal candidiasis failed to clear, nephrostomy tube irrigations were begun.


RESULTS
Fourteen days of therapy with fluconazole resulted in the resolution of the uremia. The patient died 6 months later with her nephrostomy tubes in situ and without evidence of candidiasis in her urinary tract.


CONCLUSIONS
The patient described was successfully treated without having to remove her nephrostomy tubes. Two other authors have reported the successful use of fluconazole irrigation to treat candidiasis in nephrostomy tubes that was unresponsive to systemic fluconazole. Before the appearance of these reports, the best results were obtained with removal of the catheter in renal candidiasis.
Clark
M A
MA
Wright State University School of Medicine, Department of Obstetrics and Gynecology, Dayton, OH 45409, USA.
Gaunt
T
T
Czachor
J S
JS
D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D002177:Candidiasis / Q000188:drug therapy* / Q000209:etiology; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D017809:Fatal Outcome; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use*; D016469:Fungemia / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007674:Kidney Diseases / Q000188:drug therapy* / Q000209:etiology; D009403:Nephrostomy, Percutaneous; D007507:Therapeutic Irrigation / Q000379:methods*; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy
D000935:Antifungal Agents; D015725:Fluconazole