Differential apoptotic susceptibility to anti-Fas IgM and anticancer drugs in a human endometrial adenocarcinoma cell line HHUA on laminin and type I collagen.
Apoptotic susceptibility of epithelial cells is known to be regulated by cell adhesions to basement membranes. In this study differences in anticancer drug-sensitivities of early and advanced endometrial adenocarcinomas were examined by using highly-differentiated human endometrial adenocarcinoma cell line, HHUA, whose apoptotic susceptibility was hypothesized to be modulated by extracellular matrices. The cells express high levels of laminin receptors and laminin suppressed Fas-mediated apoptosis of the cells. However laminin did not show any effect on apoptotic susceptibility to 4 anticancer drugs. These results suggest that there is little variation in drug-sensitivity associated with disruption of endometrial stromal tissue, and that pathological staging of endometrial carcinoma is not likely to have any relation to drug sensitivity.
Chang
L
L
Department of Obstetrics & Gynecology, Osaka City University, Medical School, Japan.
Tanaka
T
T
Umesaki
N
N
Ogita
S
S
D000230:Adenocarcinoma / Q000473:pathology / Q000503:physiopathology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D003094:Collagen / Q000494:pharmacology; D004351:Drug Resistance; D016889:Endometrial Neoplasms / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology / Q000494:pharmacology*; D007797:Laminin / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D019014:fas Receptor / Q000276:immunology*
D000970:Antineoplastic Agents; D007075:Immunoglobulin M; D007797:Laminin; D019014:fas Receptor; D003094:Collagen