Charcot-Marie-Tooth disease type 2 with restless legs syndrome.
In a series of 44 consecutive patients with Charcot-Marie-Tooth disease (CMT), we found restless legs syndrome (RLS) in 10 of 27 CMT type 2 (CMT2) patients (37%) and in none of 17 CMT type 1 patients (p = 0.004). In the CMT2 patients, RLS was associated with positive sensory symptoms (10/10 versus 10/17; p = 0.026). This finding supports the view that a disorder of sensory input plays a role in the pathogenesis of RLS. Symptomatic treatment may benefit these patients.
Gemignani
F
F
Institute of Neurology, University of Parma, Italy.
Marbini
A
A
Di Giovanni
G
G
Salih
S
S
Terzano
M G
MG
D000368:Aged; D002607:Charcot-Marie-Tooth Disease / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D012148:Restless Legs Syndrome / Q000150:complications* / Q000503:physiopathology*; D013497:Sural Nerve / Q000473:pathology / Q000648:ultrastructure; D013577:Syndrome