title: [Nitric oxide in the rat cerebral cortex in seizure models: potential ways of pharmacological modulation].
abstract: Seizures induced with Thiosemicarbaside, Pentylenetetrasole, N-methyl-D,L-aspartate were used as models. The NO content increased 4-5-fold in the brain cortex at the peak of seizures. The increase could be prevented by pre-treatment with N-nitro-L-arginine and the seizures were weakened. Anticonvulsant drugs reduced the seizure manifestations and partially prevented the NO generation enhancement. The latter seems to be involved in pathophysiological mechanisms underlying the seizures.
authors: Institute of Pharmacology, Russian Acad. Med. Sci., Russia, Moscow.
authors: K S
authors: KS
authors: Raevskiĭ
authors: V G
authors: VG
authors: Bashkatova
authors: V B
authors: VB
authors: Narkevich
authors: G Iu
authors: GIu
authors: Vitskova
authors: V D
authors: VD
authors: Mikoian
authors: A F
authors: AF
authors: Vanin
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001120:Arginine / Q000494:pharmacology; D003292:Convulsants / Q000633:toxicity; D016291:Dizocilpine Maleate / Q000494:pharmacology; D004578:Electron Spin Resonance Spectroscopy; D004597:Electroshock; D018690:Excitatory Amino Acid Agonists / Q000633:toxicity; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D008297:Male; D016202:N-Methylaspartate / Q000633:toxicity; D009569:Nitric Oxide / Q000378:metabolism*; D019335:Nitroarginine / Q000494:pharmacology; D010433:Pentylenetetrazole / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects; D012640:Seizures / Q000209:etiology / Q000378:metabolism* / Q000517:prevention & control; D012663:Semicarbazides / Q000633:toxicity
chemical_list: D000927:Anticonvulsants; D003292:Convulsants; D018690:Excitatory Amino Acid Agonists; D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D012663:Semicarbazides; D019335:Nitroarginine; D009569:Nitric Oxide; C005151:thiosemicarbazide; D016202:N-Methylaspartate; D016291:Dizocilpine Maleate; D001120:Arginine; D010433:Pentylenetetrazole