Role of bone marrow and thymus secretory protein in maintaining immune homeostasis and haemopoiesis in control and malnourished mice.
Injection of Salmonella typhi 'H' antigen was observed to produce a differential effect on bone marrow and thymus secretory profile depending upon the nutritional status of the host. The paracrine effect of Thy F1 (thymus fraction 1) was more significant (P < 0.01) than the autocrine effect of BIM (Bone marrow immunomodulator) in malnourished mice. BIM moreover, also had a paracrine effect on thymus irrespective of the nutritional status of the host. An improvement in neutrophil population (P < 0.01) and phagocytic myeloperoxidase activity (P < 0.01) was observed in BIM treated malnourished immuno-suppressed mice, whereas no appreciable change was observed by Thy F1. However, Thy F1 irrespective of the nutritional status of the host improved large lymphocyte population in circulation (P < 0.01). These findings indicate that both bone marrow and thymus play a major role in haemopoietic microenvironment of BDF (basal diet fed) control and malnourished mice.
Datta
S
S
Department of Chemistry, Bose Institute, Calcutta, India.
Bhattacharyya
P
P
D000818:Animals; D001854:Bone Marrow Cells / Q000502:physiology*; D002478:Cells, Cultured; D006410:Hematopoiesis / Q000502:physiology; D006706:Homeostasis / Q000502:physiology; D007107:Immune System / Q000502:physiology; D008297:Male; D051379:Mice; D009504:Neutrophils / Q000276:immunology; D009748:Nutrition Disorders / Q000276:immunology*; D010587:Phagocytosis / Q000502:physiology; D011506:Proteins / Q000502:physiology*; D013950:Thymus Gland / Q000166:cytology / Q000502:physiology*
D011506:Proteins