Preparation and properties of 2',5'-linked oligonucleotide analogues containing 3'-O,4'-C-methyleneribonucleosides.
Bicyclic nucleoside analogues, 3'-O,4'-C-methyleneuridine and -5-methyluridine, were successfully incorporated into oligonucleotides via connection with 2',5'-phosphodiester linkage, and hybridization behavior and nuclease stability of the modified oligonucleotides were investigated.
Obika
S
S
Graduate School of Pharmaceutical Sciences, Osaka University, Yamadaoka, Suita, Japan.
Morio
K
K
Hari
Y
Y
Imanishi
T
T
D001483:Base Sequence; D007700:Kinetics; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D012263:Ribonucleosides / Q000737:chemistry*
D009841:Oligonucleotides; D012263:Ribonucleosides