[New approaches to the chemotherapy of HIV infection].
The preclinical analysis of the effectiveness of AZT and new compounds (sulphatized derivate of chitosan (Sch) and adamantileted Sch, contents 10 and 18% of adamantine) prepared on the basis of chitosan (Ch), carried out with the use of the experimental clinical test system (the in vitro model of peripheral blood mononuclears of a concrete patient) developed in laboratory, is presented. Both combinations in concentration 0.01 mkg/ml are decreased HIV antigens till 6.4 and 8.6% accordingly, while whilst initial Sch hare caused less effect in 4-5 fold.
Karamova
E V
EV
Ivanovsky Research Institute of Virology, Moscow, Russia.
Sakhuriia
I B
IB
Shelkanov
M Iu
MIu
Burunova
V V
VV
Iaroslavtseva
N G
NG
Pavlova
T V
TV
Kornilaeva
G V
GV
D019380:Anti-HIV Agents / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000627:therapeutic use*; D015497:HIV-1; D006801:Humans; D015215:Zidovudine / Q000037:antagonists & inhibitors / Q000627:therapeutic use
D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors; D015215:Zidovudine