title: Mitral valve replacement in patients younger than 6 years of age.
abstract: We present our experience in mitral valve replacement (including left-sided tricuspid valve in corrected transposition) in patients younger than 6 years of age. The long term results were examined with special focus on re-replacement of the valve. Between 1974 and 1995, we performed mitral valve replacement in 14 patients younger than 6 years of age, with no operative mortality. There were 3 late deaths, caused by endocarditis, valve thrombosis, and congestive heart failure, respectively. The five-year-survival rate after primary replacement was 85%, and the ten-year-survival rate was 75%, using Kaplan-Meier analysis. Ten patients (11 occasions) required repeated mitral valve replacements at 2 months to 17 years after the original replacement. The indication for the second or third mitral valve replacement was paravalvular leakage (2 patients), valve thrombosis (1 patient), degeneration in the porcine prosthesis (3 patients), and patient outgrowth of the original small prosthesis (5 patients). Again there was no operative mortality. One patient who suffered from multiple occasions of valve thrombosis died at two years after the second replacement. All patients who had outgrown the prosthetic valve received larger prosthesis at the second replacement than at the primary replacement. The actuarial percentage of freedom from valve-related events at 3 years, 5 years, and at 10 years, was 50%, 37%, and 8%, respectively.
  
  
  CONCLUSIONS
  Mitral valve replacement in patients younger than 6 years of age can be performed relatively safely, but meticulous follow-up and appropriate decision making for re-replacement is mandatory for the long-term survival of these patients.
authors: Department of Surgery, School of Medicine, Keio University, Tokyo, Japan.
authors: T
authors: T
authors: Katogi
authors: R
authors: R
authors: Aeba
authors: Y
authors: Y
authors: Cho
authors: Y
authors: Y
authors: Inoue
authors: A
authors: A
authors: Mitsumaru
authors: S
authors: S
authors: Takeuchi
authors: S
authors: S
authors: Kawada
mesh_terms: D002648:Child; D002675:Child, Preschool; D005500:Follow-Up Studies; D019918:Heart Valve Prosthesis Implantation / Q000401:mortality; D006801:Humans; D007223:Infant; D008943:Mitral Valve / Q000601:surgery*; D012086:Reoperation; D016896:Treatment Outcome