Thyrotropin stimulating hormone response to thyrotropin releasing hormone in patients with panic disorder.
OBJECTIVE
The aim of this study is to assess thyrotropin stimulating hormone (TSH) response to thyrotropin releasing hormone (TRH) in patients with panic disorder (PD).


METHODS
The effects of TRH administration on the release of TSH were examined in 15 patients who met DSM-III-R criteria for PD and compared their test results with those of 15 normal control subjects. Blood samples were taken before TRH administration (baseline values) and at 15, 30 and 60 min.


RESULTS
delta max TSH values were lower in the panic disorder patients than in the control subjects. Using the criterion of delta max TSH < or = 7 mlU/l, nine of the 15 panic disorder patients and four of the 15 control subjects had a blunted TSH response to TRH.


CONCLUSIONS
These results confirm the findings from earlier reports that patients with PD show blunted TSH response to TRH which is similar to that seen in depressed patients.
Tükel
R
R
Department of Psychiatry, Istanbul Faculty of Medicine, Istanbul University, Turkey.
Kora
K
K
Hekim
N
N
Oğuz
H
H
Alagöl
F
F
D000328:Adult; D003866:Depressive Disorder / Q000503:physiopathology; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D016584:Panic Disorder / Q000097:blood / Q000503:physiopathology*; D013972:Thyrotropin / Q000097:blood*; D013973:Thyrotropin-Releasing Hormone
D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin