Vaginal stenosis following allogeneic bone marrow transplantation for acute myeloid leukaemia.
We report the unusual complication of vaginal stenosis occurring after allogeneic bone marrow transplantation (BMT) for leukaemia. This was in all likelihood a manifestation of chronic graft-versus-host disease (cGVHD), although the patient has no other stigmata of this and suffered little acute graft-versus-host disease (aGVHD) after BMT. Other risk factors for vaginal stenosis were considered and appear to be absent in this patient, although the total body irradiation used as part of her conditioning therapy may play a role. We suggest that vaginal stenosis may be under-reported, since female patients suffer a number of gynaecological complications after BMT, and that regular questioning and examination may aid in making an earlier diagnosis, allowing speedier instigation of therapy and thus improving quality of life.
DeLord
C
C
Department of Haematology, The Royal Marsden NHS Trust, Sutton, UK.
Treleaven
J
J
Shepherd
J
J
Saso
R
R
Powles
R L
RL
D000208:Acute Disease; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D005260:Female; D006399:Hematocolpos / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D007951:Leukemia, Myeloid / Q000628:therapy*; D014184:Transplantation, Homologous; D014623:Vaginal Diseases / Q000209:etiology* / Q000503:physiopathology