GLUT4 trafficking in insulin-sensitive cells. A morphological review.
In recent years, there have been major advances in the understanding of both the cell biology of vesicle trafficking between intracellular compartments and the molecular targeting signals intrinsic to the trafficking proteins themselves. One system to which these advances have been profitably applied is the regulation of the trafficking of a glucose transporter, GLUT4, from intracellular compartment(s) to the cell surface in response to insulin. The unique nature of the trafficking of GLUT4 and its expression in highly differentiated cells makes this a question of considerable interest to cell biologists. Unraveling the tangled web of molecular events coordinating GLUT4 trafficking will eventually lead to a greater understanding of mammalian glucose metabolism, as well as fundamental cell biological principles related to organelle biogenesis and protein trafficking.
Martin
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Centre for Molecular and Cellular Biology, University of Queensland, Brisbane, Australia.
Slot
J W
JW
James
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D016475:3T3 Cells; D002001:Adipose Tissue, Brown / Q000378:metabolism; D000818:Animals; D002478:Cells, Cultured; D004705:Endocytosis; D005089:Exocytosis; D051275:Glucose Transporter Type 4; D007150:Immunohistochemistry; D007328:Insulin / Q000378:metabolism*; D007700:Kinetics; D051379:Mice; D008954:Models, Biological; D009004:Monosaccharide Transport Proteins / Q000378:metabolism*; D009124:Muscle Proteins; D018482:Muscle, Skeletal / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D011990:Receptors, Transferrin / Q000378:metabolism; D015398:Signal Transduction
D051275:Glucose Transporter Type 4; D007328:Insulin; D009004:Monosaccharide Transport Proteins; D009124:Muscle Proteins; D011990:Receptors, Transferrin; C495693:Slc2a4 protein, mouse