Contribution of nitric oxide and sensory transmitters to non-adrenergic, non-cholinergic innervation of nasal blood vessels.
The possible contribution of a non-adrenergic, non-cholinergic (NANC) vasodilator mechanism in human nasal mucosa was studied using an in vitro muscle tension measuring technique. Strips of the nasal mucosa were suspended in a Magnus tube filled with Krebs solution and aerated with 95% O2. Isometric changes in tension were detected on administration of various drugs under electric stimulation and recorded with a transducer. The relaxing reaction under electrical train pulse stimulation with pretreatment of blockers of the autonomic nerves was suppressed by nitric oxide synthase inhibitor (L-NAME) and antagonists to the receptors of sensory nerve transmitters (Spantide, hCGRP8-37). This result suggests that nitric oxide, substance P and CGRP may be mediators in the NANC inhibitory nerve system.
Okita
W
W
Department of Otorhinolaryngology, National Tosei Hospital, Shizuoka, Japan.
Ichimura
K
K
D000465:Algorithms; D015777:Eicosanoids / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000294:innervation*; D009297:Nasal Mucosa / Q000098:blood supply* / Q000378:metabolism; D009569:Nitric Oxide / Q000502:physiology*; D013373:Substance P / Q000378:metabolism; D009435:Synaptic Transmission; D014664:Vasodilation / Q000187:drug effects
D015777:Eicosanoids; D009569:Nitric Oxide; D013373:Substance P