Excavatolides F-M, new briarane diterpenes from the gorgonian Briareum excavatum.
Eight new briarane-type diterpenes, excavatolides F-M (1-8), have been isolated from the gorgonian Briareum excavatum. The structures and relative stereochemistry of these compounds were established by spectral analysis and chemical methods. The cytotoxicity of these compounds toward various cancer cell lines has also been determined.
Sung
P J
PJ
Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung, Taiwan 804, Republic of China.
Su
J H
JH
Wang
G H
GH
Lin
S F
SF
Duh
C Y
CY
Sheu
J H
JH
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification*; D003063:Cnidaria / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006801:Humans; D007624:KB Cells; D007941:Leukemia P388 / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D009580:Nitroblue Tetrazolium; D013055:Spectrophotometry, Infrared; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D004224:Diterpenes; D009580:Nitroblue Tetrazolium