Novel substrates of yeast alcohol dehydrogenase--4. Allyl alcohol and ethylene glycol.
In the present work, we have determined the steady-state kinetic constants for yeast alcohol dehydrogenase-catalyzed oxidation of allyl alcohol (H2C = CH.CH2OH) and ethylene glycol (HOCH2.CH2OH) with NAD+, at pH 8.0; also, a kinetic mechanism for the former reaction was determined at the same pH. In addition, it was found that acrolein is a potent inhibitor of yeast alcohol dehydrogenase.
Trivić
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Leskovac
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D000171:Acrolein / Q000737:chemistry; D000426:Alcohol Dehydrogenase / Q000737:chemistry*; D019855:Ethylene Glycol / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D009243:NAD / Q000737:chemistry; D020005:Propanols / Q000737:chemistry*
D020005:Propanols; D009243:NAD; C006463:allyl alcohol; D000171:Acrolein; D000426:Alcohol Dehydrogenase; D019855:Ethylene Glycol