Dysfunctions of the epididymis as a result of primary carnitine deficiency in juvenile visceral steatosis mice.
The juvenile visceral steatosis mutant mice serve as an animal model of primary carnitine deficiency, classified as the sudden infant death syndrome. The defect in carnitine uptake was recently found to be due to a defect in the carnitine transporter gene. We herein report, for the first time, the characteristics of epididymal dysfunction in juvenile visceral steatosis mice. At 8-9 weeks of age, the epididymis was deformed and weight was significantly increased. Histologically, the duct of the proximal epididymis was dilated due to the accumulation of an unusually high level of spermatozoa. Spermatozoa were extravasated from the epididymal duct into the stroma. In contrast, the duct of the distal epididymis was constricted and contained no spermatozoa. Thus, the epididymal disorder causes obstructive azoospermia, leading to infertility.
Toshimori
K
K
Department of Anatomy and Reproductive Cell Biology, Miyazaki Medical College, Japan. ktoshi@post.miyazaki-med.ac.jp
Kuwajima
M
M
Yoshinaga
K
K
Wakayama
T
T
Shima
K
K
D000015:Abnormalities, Multiple; D000818:Animals; D002331:Carnitine / Q000172:deficiency*; D004195:Disease Models, Animal; D004822:Epididymis / Q000473:pathology*; D005298:Fertility; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009929:Organ Size
D002331:Carnitine