KR025, a new cytotoxic compound from Myxococcus fulvus.
A new bithiazole, KR-025 (1), was isolated from Myxococcus fulvus. Its structure was elucidated by spectroscopic analysis. In addition to 1, the strain produced relatively large quantities of a second, closely related antibiotic, myxothiazol. These compounds demonstrated potent cytotoxicity against human tumor cells.
Ahn
J W
JW
Korea Research Institute of Chemical Technology, P.O. Box 107, Taejon 305-600, Korea. jwahn@pado.krict.re.kr
Woo
S H
SH
Lee
C O
CO
Cho
K Y
KY
Kim
B S
BS
D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D016940:Myxococcus / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013844:Thiazoles / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000903:Antibiotics, Antineoplastic; C119163:KR 025; D013844:Thiazoles