Chemokine receptors and HIV-1: the fusion of two major research fields.
Chemokines mediate their effects by binding to cell-surface receptors that belong to the seven-transmembrane-domain superfamily of proteins. Chemokine receptors have been subject to intense scrutiny following the recent discovery that several of them are co-receptors for HIV-1. Here, Richard Horuk reviews the latest developments in chemokine receptor research with a particular focus on their role as HIV-1 co-receptors.
Horuk
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Dept of Immunology, Berlex Biosciences, Richmond, CA 94804, USA.
D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D000818:Animals; D015704:CD4 Antigens / Q000235:genetics / Q000502:physiology; D015496:CD4-Positive T-Lymphocytes / Q000821:virology; D018925:Chemokines / Q000502:physiology; D018450:Disease Progression; D005786:Gene Expression Regulation; D015699:HIV Envelope Protein gp120 / Q000378:metabolism; D015658:HIV Infections / Q000378:metabolism / Q000628:therapy / Q000821:virology; D015497:HIV-1 / Q000145:classification / Q000502:physiology*; D008253:Macaca mulatta; D046911:Macromolecular Substances; D008264:Macrophages / Q000821:virology; D008969:Molecular Sequence Data; D011820:Rabies virus; D054390:Receptors, CCR2; D019713:Receptors, CCR5 / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D019718:Receptors, CXCR4 / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D019707:Receptors, Chemokine / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D018121:Receptors, Cytokine / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D013329:Structure-Activity Relationship; D014721:Vesicular stomatitis Indiana virus
D015704:CD4 Antigens; D018925:Chemokines; D015699:HIV Envelope Protein gp120; D046911:Macromolecular Substances; D054390:Receptors, CCR2; D019713:Receptors, CCR5; D019718:Receptors, CXCR4; D019707:Receptors, Chemokine; D018121:Receptors, Cytokine; D011993:Recombinant Fusion Proteins