Specific skin lesions occurring in a patient with Hodgkin's lymphoma.
A 47-year-old man presented with a several month history of non-specific acquired ichthyosis, an unknown period of generalized lymphadenopathy and a short history of erythematous papules and nodules affecting the cutaneous drainage area of his right axillary lymph nodes. Histology confirmed these lesions to be specific lesions of Hodgkin's lymphoma; that is, metastatic retrograde lymphatic spread from his axillary lymph nodes of CD30+, CD15+, Reed-Sternberg cells as well as mononuclear Hodgkin's cells. This is the most common site and mode of spread of Hodgkin's disease to the skin. As is typical of advanced Hodgkin's disease, as evidenced by specific cutaneous involvement, this patient died shortly after definitive diagnosis was made.
Pagliaro
J A
JA
Department of Dermatology, Clatterbridge Hospital, Bebington, Wirral, Merseyside, United Kingdom.
White
S I
SI
D001707:Biopsy, Needle; D017809:Fatal Outcome; D006689:Hodgkin Disease / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D007057:Ichthyosis / Q000175:diagnosis / Q000473:pathology*; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D016539:Reed-Sternberg Cells / Q000473:pathology*; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology*