A light-diffusing device for intraoperative photodynamic therapy in the peritoneal or pleural cavity.
Light delivery to anatomic areas involved by tumor is critical for effective photodynamic therapy.  The authors provide a detailed overview of a light-diffusing device which they have used for intraoperative illumination of the peritoneal and pleural cavities in patients with tumors involving the surfaces of these cavities.  Their device represents an inexpensive modification of widely available endotracheal tubes.  It has been used to deliver intraoperative photodynamic therapy in over 50 patients without episodes of device failure.  When combined with a lipid-based, light-diffusing medium and on-line power/energy density monitoring, it allows homogeneous illumination of these complex surfaces.
Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
T F
TF
DeLaney
P D
PD
Smith
G F
GF
Thomas
Z A
ZA
Tochner
W F
WF
Sindelar
H I
HI
Pass
F S
FS
Harrington
R F
RF
Bonner
J B
JB
Mitchell
D003131:Combined Modality Therapy; D004867:Equipment Design; D005336:Fiber Optic Technology; D006414:Hematoporphyrin Photoradiation / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D007432:Intraoperative Period; D010534:Peritoneal Neoplasms / Q000188:drug therapy* / Q000601:surgery; D010997:Pleural Neoplasms / Q000188:drug therapy* / Q000601:surgery