Qualitative reasoning for AIDS treatment.
We present a qualitative model of the interaction between HIV-1 virus and human cell, based on qualitative process theory. This model can be regarded as a first step for setting up a comprehensive model of the HIV 1 infection treatment in which the possible points where a drug can attack the virus are evidentiated. The first simulation trials indicate that the model reproduces the major features of the real behavior of the virus inside and outside the human cell.
Department of Communication, Computer and System Sciences, University of Genova, Italy.
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M
Giacomini
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C
Ruggiero
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S
Gaglio
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy / Q000517:prevention & control*; D002455:Cell Division / Q000502:physiology*; D003198:Computer Simulation; D015195:Drug Design; D005103:Expert Systems; D015497:HIV-1 / Q000187:drug effects* / Q000254:growth & development*; D006801:Humans; D007558:Italy; D008954:Models, Biological; D012194:RNA-Directed DNA Polymerase