Chemical stress relaxation of polyglycolic acid suture.
Chemical stress relaxation methods are employed to study chemical and mechanical factors influencing the degradation of uncoated polyglycolic (PG) sutures.  Specially constructed instrumentation is used to study the kinetics of the load bearing capability of PG (Dexon¿) 3-0 sutures in hydrolytic solution.  The effects of pH, temperature, strain rate, and initial load on the rate of chemical stress relaxation are presented.  Data show how mechanical factors such as the rate of loading (related to the speed of knot tying), as well as the final tension, are related to the rate of structural degradation.  Maximum stability is observed at approximately 40 degrees C, with slower degradation both above and below this point.  Results show that the slower and tighter the suture is pulled, the greater its ability to sustain tensile loads during hydrolysis.
Columbia Laboratories, Inc., Buffalo, New York 14214.
M J
MJ
Hayes
M D
MD
Lauren
D001673:Biodegradation, Environmental; D006801:Humans; D008422:Materials Testing; D011100:Polyglycolic Acid / Q000737:chemistry*; D013314:Stress, Mechanical; D013537:Sutures; D013718:Tensile Strength; D016474:Weight-Bearing