Biologically modified PHEMA beads for hemoperfusion: preliminary studies.
Polyhydroxyethylmethacrylate (PHEMA) beads were prepared by phase separation polymerization.  Hydroxyl groups on PHEMA beads were activated with CNBr at alkaline pH.  Adsorption of heparin, blood proteins (i.e. albumin, fibrinogen and gamma-globulin), protein A, HIgG and DNA on these beads were studied.  Preparation and activation procedures are given here.  The preliminary results of these studies are also reported.
Chemical Engineering Department, Hacettepe University, Ankara, Turkey.
A
A
Denizli
A
A
Tuncel
M
M
Olcay
V
V
Sarnatskaya
V
V
Sergeev
V G
VG
Nikolaev
E
E
Piskin
D000327:Adsorption; D000974:Antibodies, Antinuclear; D001798:Blood Proteins / Q000008:administration & dosage / Q000627:therapeutic use; D004247:DNA / Q000302:isolation & purification; D006464:Hemoperfusion / Q000295:instrumentation* / Q000379:methods; D006493:Heparin / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007074:Immunoglobulin G; D011102:Polyhydroxyethyl Methacrylate / Q000138:chemical synthesis / Q000493:pharmacokinetics; D013205:Staphylococcal Protein A / Q000008:administration & dosage / Q000627:therapeutic use