A silver-sulfadiazine-impregnated synthetic wound dressing composed of poly-L-leucine spongy matrix: an evaluation of clinical cases.
The management of severe burns requires the suppression of bacterial growth, particularly when eschar and damaged tissue are present.  For such cases, silver sulfadiazine (AgSD) cream has been traditionally applied.  This antibacterial cream, however, cannot be used in conjunction with a temporary wound dressing that is needed to promote healing.  The authors developed a synthetic wound dressing with drug delivery capability for clinical use by impregnating a poly-L-leucine spongy matrix with AgSD, which is released in a controlled, sustained fashion.  In general, the dressing adhered firmly to the wound in the case of superficial second-degree burns, and during the healing process it separated spontaneously from the re-epithelialized surface.  In the management of deep second-degree burns where eschar and damaged tissue were present, the dressing had to be changed at intervals of 3 to 5 days until it adhered firmly to the wound.  Once the dressing had firmly attached to the wound, it was left in place until it separated spontaneously from the re-epithelialized surface.  Dressing changes were fewer than with other treatments and the pain was effectively reduced. Cleansed wounds were effectively protected from bacterial contamination. Of 52 cases treated with this wound dressing, 93% (14/15) of superficial second-degree burns, 75% (3/4) of deep second-degree burns, 85% (6/7) of superficial and deep second-degree burns, and 75% (12/16) of split-thickness skin donor sites were evaluated as achieving good or excellent results.
Department of Biomedical Engineering and Department of Plastic Reconstructive Surgery, School of Medicine, Kitasato University, Sagamihara, Kanagawa, Japan.
Y
Y
Kuroyanagi
E
E
Kim
M
M
Kenmochi
K
K
Ui
H
H
Kageyama
M
M
Nakamura
A
A
Takeda
N
N
Shioya
D000328:Adult; D001424:Bacterial Infections / Q000188:drug therapy; D002056:Burns / Q000188:drug therapy*; D002675:Child, Preschool; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009779:Occlusive Dressings; D010455:Peptides / Q000627:therapeutic use*; D012837:Silver Sulfadiazine / Q000627:therapeutic use*; D012883:Skin Ulcer / Q000188:drug therapy*; D014945:Wound Healing / Q000187:drug effects*