Motor activation by single-photon emission computed tomography.  A comparison of xenon-133 and technetium-99m HM-PAO "split-dose" methods.
Single-photon emission computed tomography (SPECT) was used to investigate the feasibility of the technetium 99m-hexamethylpropyleneamineoxime ( 99mTc HM-PAO) split-dose method to evidence changes in regional cerebral blood flow during a motor activation task, in comparison with a quantitative method using the inhalatory xenon-133.  Four subjects were studied twice with both methods, at rest and during finger opposition movements.  On the activated cerebral hemisphere, a significant increase in regional cerebral blood flow was observed over the motor cortical areas.  The average increases were +28.1 +/- 5.6% for the xenon-133 method and +12.3 +/- 5.2% for the  99mTc HM-PAO method.  By using the linearization algorithm for the  99mTc HM-PAO method, a mean increase of +22.5 +/- 8.9% was calculated.  This study demonstrated that the split-dose method allows the motor activation SPECT studies with  99mTc HM-PAO to be done in a single session.
Dipartimento di Scienze Neurologiche, Università di Roma "La Sapienza," Italy.
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D000704:Analysis of Variance; D001783:Blood Flow Velocity / Q000502:physiology; D001921:Brain / Q000000981:diagnostic imaging; D005069:Evaluation Studies as Topic; D005385:Fingers; D006801:Humans; D009043:Motor Activity / Q000502:physiology; D015609:Organotechnetium Compounds / Q000008:administration & dosage*; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods* / Q000706:statistics & numerical data; D014980:Xenon Radioisotopes / Q000008:administration & dosage