Molecular genetics diagnostic applications in oncology.
The use of lineage and cytogenetic probes in diagnosis of oncologic disorders is reviewed. The presence of rearranged bands via Southern blot analysis may generate diagnostic support of hematopoietic malignancy in several instances.  DNA probes can be used to demonstrate clonality, reveal lineage characteristics, or identify specific chromosomal aberrations.  Lineage probes detect genetic events during normal lymphocyte differentiation, while cytogenetic probes detect a malignant characteristic. The number of translocations detectable using DNA probes will likely expand in the future.
Hirsch-Ginsberg
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The University of Texas M.D. Anderson Cancer Center, Hematopathology Program, Houston 77030.
deLeon
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D015139:Blotting, Southern; D015342:DNA Probes; D006402:Hematologic Diseases / Q000175:diagnosis; D006801:Humans; D015335:Molecular Probes; D009369:Neoplasms / Q000175:diagnosis*; D014178:Translocation, Genetic