The influence of bacterial contaminations on the biodegradation of PLA implants.
Metal implants employed in orthopaedic surgery have certain disadvantages.  Intensive research work is therefore being done in the field of biodegradable implants, the behavior of which in the case of possible contamination or infection at the operation site has not yet been studied.  In-vitro experiments on PLA-test bodies were performed to clarify the influence of bacteria on the polymer degradation. The investigated parameters were germ growth, course of the pH-value of the culture media, bending stiffness of the PLA-test bodies and the decrease in their molecular weight.  The experiments performed did not demonstrate an accelerated degradation of PLA specimen in vitro incubated in different bacterial contaminated media.  Therefore bacterial contamination may possibly not lead to a premature collapse of the PLA used in connection with fracture treatment by biodegradable osteosynthesis implants.
Chirurgische Klinik und Poliklinik der Ludwig-Maximilians-Universität München, Unfallchirurgie, FRG.
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Hofmann
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Liedtke
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Ruckdeschel
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Lob
D001424:Bacterial Infections / Q000150:complications*; D001673:Biodegradation, Environmental; D004866:Equipment Contamination; D005593:Fracture Fixation, Internal / Q000295:instrumentation; D006801:Humans; D006863:Hydrogen-Ion Concentration; D016268:Internal Fixators; D007773:Lactates / Q000737:chemistry / Q000378:metabolism; D008422:Materials Testing; D008970:Molecular Weight; D011108:Polymers / Q000737:chemistry / Q000378:metabolism; D013718:Tensile Strength