Clinical and economic evaluation of benzodiazepines: a value analysis.
Benzodiazepines are one of the most frequently prescribed classes of medications in the world.  Thought to relieve the symptoms of anxiety, insomnia, epilepsy, and some less common conditions, these medications are supported by a body of clinical trials demonstrating efficacy.  However, there is also literature that suggests problems of abuse and dependence, along with some serious adverse effects.  The present article utilises a value-analysis strategy to outline the clinical efficacy and economic efficiency of benzodiazepines from a variety of perspectives including those of the patient, physician and manufacturer.  Results of this analysis suggest that these medications are effective when used appropriately, but that implementation of appropriate use is difficult. Remedies to this situation are discussed.
Northwestern University Medical School, Chicago, Illinois.
J S
JS
Lyons
D B
DB
Larson
J
J
Hromco
D001569:Benzodiazepines / Q000191:economics* / Q000627:therapeutic use*; D003362:Cost-Benefit Analysis; D006801:Humans; D011787:Quality of Health Care