Treatment of combined renal failure and lactic acidosis by haemofiltration.
Twelve patients with renal failure and type A lactic acidosis were treated with haemofiltration during a 30-month period.  The first three patients received only lactate-buffered replacement fluid and rapidly succumbed despite the infusion of large quantities of sodium bicarbonate.  Bicarbonate-buffered replacement fluid was used for the remaining nine patients, of whom three survived.  Haemofiltration with bicarbonate-buffered replacement fluid is an effective method of replacing renal function for this group of critically-ill patients.
Department of Renal Medicine, St. Thomas' Hospital, Lambeth Palace Road, London, UK.
I K
IK
Barton
P J
PJ
Hilton
D F
DF
Treacher
R D
RD
Bradley
D000140:Acidosis, Lactic / Q000378:metabolism / Q000401:mortality / Q000628:therapy*; D058186:Acute Kidney Injury / Q000209:etiology / Q000378:metabolism / Q000628:therapy*; D000293:Adolescent; D000328:Adult; D000368:Aged; D001639:Bicarbonates / Q000627:therapeutic use; D002648:Child; D005069:Evaluation Studies as Topic; D005440:Fluid Therapy / Q000379:methods; D006440:Hemofiltration / Q000379:methods* / Q000401:mortality; D006801:Humans; D008875:Middle Aged