New intraoperative cardioprotective strategies for myocardial protection.
Three clinical techniques providing significant changes in the approach to myocardial protection have been reported recently. These techniques deviate from conventional practice, and they infer that normothermia is superior to hypothermia, retrograde cardioplegia is more advantageous than antegrade administration, and continuous cardioplegic delivery is preferable to intermittent dosage. Encouraging preliminary clinical results with warm-blood cardioplegia are reported, but rigid clinical and experimental testing against conventional methods is not yet available for evaluation.  The ideal cardioprotective strategy has yet to be determined, but these preliminary data suggest strongly that incorporation of these techniques with conventional methods will improve intraoperative myocardial protection and provide the cardiac surgeon with an augmented arsenal of strategies that can be employed to provide increased flexibility.
University of California-Los Angeles Medical Center.
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Kato
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Buckberg
D000818:Animals; D003327:Coronary Disease / Q000601:surgery*; D003331:Coronary Vessels / Q000601:surgery*; D004285:Dogs; D006324:Heart Arrest, Induced / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D007430:Intraoperative Care / Q000379:methods; D013552:Swine