Diabetic nephropathy: pathogenetic basis for treatment.
For maximal effectiveness, interventions to prevent diabetic nephropathy are initiated prior to clinically detectable proteinuria--during the microalbuminuria stage. Effects of therapy in relation to pathologic processes are described.
Division of Endocrinology and Metabolism, University of Texas Health Science Center, San Antonio, USA.
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Reasner
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DeFronzo
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D003928:Diabetic Nephropathies / Q000503:physiopathology / Q000517:prevention & control* / Q000628:therapy; D018753:Diet, Protein-Restricted; D004232:Diuretics / Q000627:therapeutic use; D006801:Humans; D006977:Hypertension, Renal / Q000188:drug therapy / Q000503:physiopathology; D011507:Proteinuria / Q000209:etiology / Q000503:physiopathology