Techniques for vascular access when venous entry is impossible. Route depends on urgency and the agent to be administered.
When a patient requires parenteral fluid or drug administration and venous cannulation cannot be performed, consider less typical routes. Intraosseus infusions are usually more effective in children than adults, but intraosseus cannulation failure may occur in as many as 20% of patients.  Intra-arterial infusions are possible if pump pressures are kept high.  Hypodermoclysis (infusion into the subcutaneous tissues) can correct moderate dehydration.  Administering resuscitative drugs endobronchially is usually safe and effective, although pulmonary function may be somewhat compromised.  A number of drugs may be given sublingually, either by injection or topical application.  Finally, the corpora cavernosa of the penis may be used for short-term, large-volume fluid administration.
Vyskocil
J J
JJ
Pulmonary/Critical Care Medicine, Wayne State University School of Medicine, Detroit.
Kruse
J A
JA
Wilson
R F
RF
D016638:Critical Illness; D004333:Drug Administration Routes; D005440:Fluid Therapy / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D010288:Parenteral Nutrition / Q000379:methods