In vivo evaluation of 2-cyanoacrylates as surgical adhesives.
To evaluate 2-cyanoacrylates as surgical adhesives, the bond strength in vivo as well as the tissue reaction was investigated using methyl-, ethyl-, isobutyl-, and ethoxyethyl-2-cyanoacrylate.  In addition, their set time and spreading on blood were studied.  When the 2-cyanoacrylates were applied to an incised site of rabbit skin, they could maintain the skin closure without suturing during the first week and the bond strength increased during the second week.  Significant inflammatory response was observed around the subcutaneous tissue glued with methyl- and ethoxyethyl-2-cyanoacrylate and persisted for approximately one week. All the 2-cyanoacrylate polymers were absorbed and the tissues treated were healed two weeks after the operation.  There was a mild inflammatory reaction in the tissue treated with ethyl- and isobutyl-2-cyanoacrylate, and their polymers still remained at the wound site at the second week postoperatively.  The disappearance rate of the 2-cyanoacrylate polymers was roughly in proportion to the inflammatory tissue response.  Ethoxyethyl-2-cyanoacrylate spread more broadly on tissues than the other 2-cyanoacrylates, while its set time was shorter than that of methyl- and ethyl-2-cyanoacrylates.
Research Center for Medical Polymers and Biomaterials, Kyoto University, Japan.
Y C
YC
Tseng
S H
SH
Hyon
Y
Y
Ikada
Y
Y
Shimizu
K
K
Tamura
S
S
Hitomi
D000818:Animals; D003487:Cyanoacrylates; D062109:Dermatologic Surgical Procedures; D005069:Evaluation Studies as Topic; D005260:Female; D008422:Materials Testing; D011817:Rabbits; D012867:Skin / Q000473:pathology; D013536:Suture Techniques; D013718:Tensile Strength; D013997:Time Factors; D014014:Tissue Adhesives