Comparison of the early healing course of porous titanium with hydroxyapatite-coated porous titanium hip implants:  clinical considerations for the use of hydroxyapatite coating in total hip replacement.
The role of hydroxyapatite (HA) coating in the fixation of human total joint prostheses remains to be established.  Results of animal studies have been favorable, showing very rapid bone formation with a corresponding increase in bone-implant bond strength.  In addition, the quantity of bone may be increased.  This study compared identical porous titanium primary total hip implants with and without HA in similar patient populations.  All of these patients were healthy and reliable, and had optimal bone geometry and bone quality for cementless fixation.  The purpose of the study was to contrast the sequence of events, in the first year after surgery, between the two implant groups to identify the contribution of HA to early patient function and early radiographic appearance of the prosthesis.  No significant clinical difference could be demonstrated between the two groups at 1 year from surgery.  However, the HA group progressed more rapidly when comparing clinical scores at 6 months (P = .0058), and appeared to demonstrate more rapid bone remodeling at 6 months on the femoral side, although this observation did not quite make statistical significance (P = .0618).  There was no difference between the acetabular components during the course of this study.
Department of Orthopedic Surgery, Southwestern Medical School, Dallas, TX.
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D005260:Female; D005500:Follow-Up Studies; D006622:Hip Prosthesis / Q000295:instrumentation*; D006801:Humans; D006882:Hydroxyapatites; D008297:Male; D008875:Middle Aged; D011474:Prosthesis Design; D014025:Titanium; D014945:Wound Healing