Feasibility of a low dosage dynamic powder dispenser for drug delivery to the lungs.
Inhalation of drugs offers the opportunity to treat diseases of the respiratory tract.  A manually operated prototype, called Dynamic Powder Dispenser (DPD), for dispensing a predetermined amount of powdered drug has been developed.  This device actively disperses powder from a chamber through a mouthpiece ready for inhalation.  The DPD is a multi-single dose device which delivers drugs actively and does not require breath actuation.  This DPD which insufflates dry powder into the respiratory tract can be considered as a counterpart to an MDI.  The respirable fraction was found in-vitro in the range of 10% and 25% for salbutamol and terbutaline, respectively.
Ing. E. Pfeiffer GmbH & Co. KG, Radolfzell, Germany.
R
R
Jäger-Waldau
H
H
Mehring
J D
JD
Wiggins
D000280:Administration, Inhalation; D000420:Albuterol; D005069:Evaluation Studies as Topic; D006801:Humans; D009330:Nebulizers and Vaporizers; D011208:Powders / Q000008:administration & dosage*; D013726:Terbutaline