A new bioactive bone cement: its histological and mechanical characterization.
We have developed a bioactive bone cement using CaO-SiO 2-P 2O 5-CaF 2 glass powders and ammonium phosphate solution, and investigated its histological and mechanical characteristics in vivo. A bone defect was drilled in proximal metaphysis of the rat tibia and filled with the bioactive bone cement in paste form or polymethylmethacrylate (PMMA) bone cement in the dough state.  The cements were allowed to harden in situ.  Histological examination demonstrated direct bonding between the new cement and bone by 4 weeks.  The bioactive bone cement did not degrade up to 24 weeks postimplantation.  The inflammatory reaction to the bioactive bone cement was less intense than the reaction induced by PMMA.  Changes in the mechanical properties of the cement in vivo were studied by implanting hardened cylindrical specimens of both types of cement into the hindlimb muscles of rats for 12 weeks.  The compressive strength of the bioactive cement increased significantly after implantation, and reached 68 MPa in 1 week and 73 MPa in 4 weeks.  These values were comparable to those of PMMA, and were maintained up to 12 weeks after implantation.  This bioactive bone cement hardens in situ within a few minutes with negligible rise of temperature and can be easily handled as a paste for filling bone cavities of different shapes.  In addition, this cement has good osteoconductive and bone bonding potential and fairly high mechanical strength.  Therefore, this new cement could be used both as a bioactive bone cement and bone defect filler.
Department of Orthopedic Surgery, Kyoto University, Japan.
N
N
Nishimura
T
T
Yamamuro
Y
Y
Taguchi
M
M
Ikenaga
T
T
Nakamura
T
T
Kokubo
S
S
Yoshihara
D000818:Animals; D001843:Bone Cements / Q000737:chemistry; D001842:Bone and Bones / Q000033:anatomy & histology; D005898:Glass; D008297:Male; D008422:Materials Testing; D008768:Methylmethacrylates; D016348:Osseointegration; D010710:Phosphates; D051381:Rats; D011919:Rats, Inbred Strains; D013314:Stress, Mechanical; D013718:Tensile Strength