Medication monitoring in the elderly.
OBJECTIVE
To review changes associated with aging that affect medication use and to outline medication-monitoring guidelines.


METHODS
Recent medical literature including journals and texts.


METHODS
Determined by the author.


METHODS
By the author.


RESULTS
There are many changes that occur in the aging individual that may affect medication use. Alterations in organ function, especially that of the liver and kidneys, may potentiate drug effects. Appropriate use of serum-drug concentrations, used in conjunction with standard clinical observations, is an effective means of monitoring the patient. Medications with a high risk of toxicity in the elderly, such as phenytoin, theophylline, and digoxin, may be used with a much higher degree of safety if serum concentrations are obtained. Blood samples must be obtained at appropriate times to ensure accurate interpretation of the drug concentration.


CONCLUSIONS
When performed appropriately, serum-concentration monitoring of medications is a valuable method of reducing toxicity in the elderly.
Fowler
J B
JB
Department of Veterans Affairs Medical Center, Lexington, Kentucky 40511, USA.
D000367:Age Factors; D000368:Aged; D000375:Aging / Q000502:physiology*; D016903:Drug Monitoring / Q000379:methods*; D005853:Geriatrics; D006801:Humans; D010599:Pharmacokinetics; D017410:Practice Guidelines as Topic