Clinical insights from the etiopathology of osteoporosis.
Bone resorption may be stimulated by increased parathyroid hormone secretion, certain cytokines, and other bone-resorbing mediators. Low serum calcium levels promote parathyroid hormone secretion, and estrogen deficiency is associated with a rise in cytokine production and activity. An abnormal proliferation of mast cells may also release cytokines, heparin, and other mediators of bone resorption.
Hospital for Special Surgery, New York City, USA.
B A
BA
Piper
T D
TD
Galsworthy
R S
RS
Bockman
D006801:Humans; D010024:Osteoporosis / Q000209:etiology / Q000503:physiopathology*