Alkyl cyanoacrylates as space filling bone adhesives.
Higher chained alkyl cyanoacrylates have potential to function efficiently as space filling, hydrophobic, viscoelastic, biocompatible, and rapidly polymerizing bone adhesives.  Hence they may be useful in applications where a void has to be filled, such as replacement of the intervertebral disc.  To assess their applicability as space filling material in such an application, three alkyl cyanoacrylates; methoxyethyl cyanoacrylate, isobutyl cyanoacrylate, and isoamyl cyanoacrylate have been evaluated in this study.  The bonding strength of these cyanoacrylates to bone in a space filling situation have been measured.  The results indicate the bond strength of isoamyl cyanoacrylate (0.13 MPa) to be significantly (p less than 0.05) lower compared with methoxyethyl cyanoacrylate (0.33 MPa) and isobutyl cyanoacrylate (0.37 MPa).  There was no significant difference in the bond strengths of isobutyl cyanoacrylate and methoxyethyl cyanoacrylate.
Bhat
S
S
Department of Biomedical Engineering, University of Akron, OH 44325.
Askew
M J
MJ
Njus
G
G
Smith
D J
DJ
D000818:Animals; D001843:Bone Cements; D002417:Cattle; D003487:Cyanoacrylates / Q000737:chemistry / Q000627:therapeutic use*; D005069:Evaluation Studies as Topic; D008422:Materials Testing; D013314:Stress, Mechanical; D013718:Tensile Strength