A new bioactive bone cement consisting of BIS-GMA resin and bioactive glass powder.
We have developed a bioactive bone cement consisting of silane-treated CaO-SiO 2-P 2O 5-CaF 2 glass powder as the filling particles and bisphenol-a-glycidyl methacrylate (BIS-GMA) diluted with triethylene-glycol dimethacrylate (TEGDMA) as the organic matrix.  Histological examination demonstrated direct bonding between the cement and bone along the circumference of the cement at 4 weeks after implantation in rat tibia.  The compressive strength and toughness of the cement were two and four times greater than those of polymethylmethacrylate (PMMA) cement, respectively.  The inflammatory reaction of the skin caused by the new cement was not as intense as that for PMMA 3 days after subcutaneous implantation.  This new cement may be applicable as a bioactive bone cement with high mechanical strength.
Department of Orthopedic Surgery, Faculty of Medicine, Kyoto University, Japan.
K
K
Kawanabe
J
J
Tamura
T
T
Yamamuro
T
T
Nakamura
T
T
Kokubo
S
S
Yoshihara
D000818:Animals; D017438:Bisphenol A-Glycidyl Methacrylate / Q000009:adverse effects; D001843:Bone Cements; D005069:Evaluation Studies as Topic; D005899:Glass Ionomer Cements; D008297:Male; D008422:Materials Testing; D008768:Methylmethacrylates / Q000009:adverse effects; D008855:Microscopy, Electron, Scanning; D016348:Osseointegration; D010784:Photomicrography; D011208:Powders; D051381:Rats; D017208:Rats, Wistar; D012821:Silanes; D013314:Stress, Mechanical; D013718:Tensile Strength