Treatment of homozygous familial hypercholesterolemia by plasma exchange and LDL-apheresis.
Two girls with familial hypercholesterolemia were treated for 7 years by plasma exchanges (PE) or LDL-apheresis (LA).  We compared different methods of treatment; PE with or without reuse of the plasma separator, LA of varying frequency, and LA with or without oral administration of simvastatin.  We assessed the long-term results by measuring the blood levels of the biochemical parameters before sessions, and determined the effectiveness of each session by the percentage of decrease in the blood levels between the beginning and the end of the sessions.  LA led to a more selective treatment (lowering of LDL cholesterol and maintenance of HDL cholesterol), but the blood levels of total cholesterol before sessions were the same as those obtained by PE.  IgG and haemoglobin levels decreased little with LA.  The rhythm of one session a week gave better results in LA.  Although reuse of the plasma separator represents a financial saving it produced poorer results.  The oral administration of simvastatin improved the results of LA.
Department of Paediatrics, Faculté de Médecine, Clermont-Ferrand, France.
J B
JB
Palcoux
M
M
Meyer
P
P
Jouanel
A
A
Tridon
P
P
Vanlieferinghen
H
H
Carla
G
G
Malpuech
D000293:Adolescent; D001810:Blood Volume; D008078:Cholesterol, LDL / Q000097:blood* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000628:therapy*; D008148:Lovastatin / Q000031:analogs & derivatives; D010951:Plasma Exchange / Q000379:methods; D010956:Plasmapheresis / Q000379:methods*