Biliary calculi fragmentation by a 308 nm excimer laser: a preliminary study.
The use of a 308-nm XeCl excimer laser for biliary stone fragmentation is reported.  The 130-nsec laser pulses are delivered via UV grade fused silica fibers to the target stones immersed in normal saline solution and placed in direct contact with the fiber.  Sixty biliary calculi, 20 cholesterol and 40 pigment, were fragmented in vitro.  The energy delivered per unit mass of the stone is kept constant at 50 mJ/mg.  The effect of laser repetition rate, energy fluence, and fiber core size on stone fragmentation was studied.  Fragmentation thresholds for a variety of biliary calculi of known composition were measured.  It was found that higher fragmentation efficiency was obtained with larger fluence, lower repetition rate, and fiber of larger core.  Our study indicates that the 308-nm excimer laser may be effective as a laser lithotriptor with low threshold and good efficiency for biliary stone fragmentation.
Laser Research Center, Cedars-Sinai Medical Center, Los Angeles, CA.
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Daykhovsky
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D005069:Evaluation Studies as Topic; D042882:Gallstones / Q000737:chemistry / Q000628:therapy*; D006801:Humans; D053685:Laser Therapy; D008096:Lithotripsy / Q000379:methods*; D017602:Lithotripsy, Laser