Transcatheter stenting of the ductus arteriosus:  evaluation as an alternative to surgical shunts.
Implantation of 3.5 mm Gianturco-Roubin coronary artery stents into the ductus arteriosus was evaluated as an alternative to surgical systemic to pulmonary arterial shunts in 3 weanling piglets.  Thrombosis of the ductus occurred in all 3 animals (95% confidence limits 29-100%) within 1 hour, despite pretreatment with heparin.  In each case, thrombus filled the ductus arteriosus but did not extend to any extraductal portion of the stents.  Rapid, heparin-resistant thrombus formation precludes use of this stent procedure as an alternative to surgical shunts.
Steele Memorial Children's Research Center, The University of Arizona, Tucson.
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TR
Lloyd
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MA
Markowitz
D000818:Animals; D001166:Arteriovenous Shunt, Surgical; D004373:Ductus Arteriosus / Q000033:anatomy & histology / Q000473:pathology; D006330:Heart Defects, Congenital / Q000628:therapy; D015607:Stents; D013552:Swine