Long-term follow-up of renal transplantation for Wegener's disease.
Eight patients with end-stage renal failure due to Wegener's granulomatosis underwent renal transplantation at the University of Minnesota.  Seven patients were alive with a functioning graft 40 to 128 months posttransplant (mean follow-up:  91 months).  One patient died 126 months posttransplant with a well-functioning graft. Posttransplant immunosuppression controlled primary disease in all but 1 patient, who presented with perisinusitis.  Recurrent disease was not noted in any of the transplanted organs.  We conclude that transplantation is an excellent treatment for renal failure secondary to Wegener's disease.
Department of Surgery, University of Minnesota, Minneapolis.
P J
PJ
Tzardis
R W
RW
Gruessner
A J
AJ
Matas
W D
WD
Payne
D L
DL
Dunn
D E
DE
Sutherland
J S
JS
Najarian
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D014890:Granulomatosis with Polyangiitis / Q000150:complications / Q000601:surgery*; D006680:HLA Antigens; D006801:Humans; D007165:Immunosuppression Therapy; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care