Skin replacement using collagen extracted from bovine hide.
This paper reviews the use of biological sponge-shape matrices as dermal replacements in order to orient newly formed wound tissue. Sponge-shape matrices consist of a scaffold made of cross-linked collagen extracted from bovine hide.  Other molecules with specific activities on wound tissue ingrowth are bound to collagen.  The lamination of sponge with a synthetic material allows this device to be implanted as a temporary skin substitute.  For the epidermal cell layer replacement, a biological film-shape matrix can be used in order to cultivate autologous cells during the period that biological sponge-shape matrices are invaded by wound tissue.
Doillon
C J
CJ
Department of Surgery, Laval University and Saint-François d'Assise's Hospital, Québec, Canada.
D000818:Animals; D001684:Biological Dressings; D002417:Cattle; D003094:Collagen / Q000494:pharmacology*; D003432:Cross-Linking Reagents / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D012038:Regeneration / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects