Apoprotein assays: radial immunodiffusion versus an immunoturbidometric technique.
The measurement of apolipoprotein using radial immunodiffusion (RID) and Cobas-Bio immunoturbidometric assays is compared. Samples were obtained from 100 patients in a fiber-diet study.  RID assays were performed using plates, standards, and diluent from Tago Inc.  The immunonephelometric assays were performed on a Cobas-Bio with DENS program centrifugal analyzer. The correlation coefficient for the apolipoprotein Al was 0.90 and for apolipoprotein B was 0.91.  The bias of the RID was to report higher values. The Cobas-Bio system affords the clinical laboratory with a reliable and cost-effective means for assessing these apolipoproteins.
Department of Clinical Sciences, University of Kentucky, Lexington  40517.
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Gorman
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Adkins
D001053:Apolipoproteins / Q000032:analysis*; D003362:Cost-Benefit Analysis; D004043:Dietary Fiber; D006801:Humans; D005779:Immunodiffusion / Q000191:economics / Q000379:methods*; D009391:Nephelometry and Turbidimetry / Q000191:economics / Q000379:methods*