A comparison of duplex Doppler ultrasonography and intrarenal manometry in the diagnosis of acute renal transplant rejection.
Renal transplant rejection is frequently difficult to differentiate from other causes of renal dysfunction.  This study examined the use of duplex Doppler ultrasound and intrarenal manometry in a consecutive series of 73 patients who underwent renal transplantation.  Altogether 327 duplex scans were analyzed and, for each, a resistive index (RI) was calculated.  A raised RI predicted rejection in patients with grafts that functioned immediately, but not in those that had delayed function.  A rise in intrarenal pressure ( greater than or equal to 40 mmHg) indicated the presence of rejection in both groups.  However, neither test had a sensitivity of more than 71% and this was not improved by combining the results of the two tests for each patient.  Although both tests have a place in transplantation, renal biopsies may still be required to confirm rejection.
Renal Transplant Unit, Royal Infirmary, Cardiff, Wales, U.K.
H
H
Krishnan
D
D
Cochlin
R
R
Moore
P
P
Griffin
J R
JR
Salaman
D000293:Adolescent; D000328:Adult; D000368:Aged; D003404:Creatinine / Q000097:blood; D005260:Female; D006084:Graft Rejection / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects / Q000502:physiology; D008297:Male; D008365:Manometry / Q000295:instrumentation / Q000379:methods*; D008875:Middle Aged; D012079:Renal Circulation / Q000502:physiology; D012680:Sensitivity and Specificity; D014463:Ultrasonography / Q000295:instrumentation / Q000379:methods*