Compliance of an apatitic calcium phosphate cement with the short-term clinical requirements in bone surgery, orthopaedics and dentistry.
An apatitic calcium phosphate cement was developed containing a nucleator in its powder and an accelerator in the liquid and having an initial setting time of 7.5 min and a final setting time of 12.5 min according to testing with Gillmore needles at room temperature. At body temperature the initial setting time is 6 min, after which the wound can be closed. The dough time (during which it can be deformed without damaging its microstructure) is 4 min. Therefore, the time lost during an operation with this material is 2 min. The product does not shrink or expand during setting, neither is there a thermal effect; it does not swell or disintegrate upon exposure to aqueous fluids after initial setting. Upon soaking in Ringer's solution the product obtains a final compressive strength of 40 MPa and 65% of that strength is reached within 6 h at body temperature. Cytotoxicity is absent. Applications are envisaged in bone surgery, orthopaedics and dentistry, a.o. for acceleration of the osseointegration of metal endoprostheses.
Department of Materials Science and Metallurgy, Universitat Politècnica de Catalunya, Barcelona, Spain.
M P
MP
Ginebra
E
E
Fernández
M G
MG
Boltong
O
O
Bermúdez
J A
JA
Planell
F C
FC
Driessens
D001672:Biocompatible Materials; D001843:Bone Cements / Q000737:chemistry / Q000592:standards; D001842:Bone and Bones / Q000601:surgery; D002130:Calcium Phosphates; D003738:Dental Cements / Q000737:chemistry / Q000592:standards; D006801:Humans; D009985:Orthopedics; D013997:Time Factors