Value of  111indium leukocyte scanning in febrile organ transplant patients.
Immunosuppressed febrile organ transplant patients present a diagnostic and therapeutic dilemma since symptomatology is often altered by immunosuppression, which also masks the location of infection.  Fifty 111indium leukocyte ( 111In WBC) scans were performed to determine their usefulness in the organ transplant patient.  The results were compared with computerized tomography (CT) and gallium 67-citrate (Ga) scanning.  Eleven patients received both 111In WBC and Ga scans; 22 received both  111In WBC and CT scans.  Ten  111In WBC scans had subtraction of 99m Tc sulfur or albumin colloid for liver evaluation and four 111In WBC scans had subtraction of 99m Tc DMSA for kidney evaluation.  The overall sensitivity and specificity for 111In WBC scans was 90% and 90%, respectively.  Lung uptake was sensitive (89%) and specific (97%) for pulmonary infections, including bacterial, fungal and cytomegalovirus pneumonias.  Renal graft uptake occurred in 15 cases (41%), all except 2 being due to rejection, pyelonephritis, urinary tract infections, or cytomegalovirus infections.  Pyelonephritis and renal abscesses were diagnosed in 3 cases with 99m Tc DMSA subtraction.  Perihepatic abscesses (2), and infected liver cysts (4) were diagnosed with 99m Tc sulfur or albumin colloid subtraction.  There were five false-negative CT scans and three false-negative Ga scans.  Therefore, when compared with 111In: sensitivity = 88% vs 64% (CT), specificity = 80% vs 86% (CT); and sensitivity = 111In 90% vs 67% (Ga), specificity = 100% for both  111In WBC and Ga scans.(ABSTRACT TRUNCATED AT 250 WORDS)
Transplantation Service, Department of Surgery, Hartford Hospital, University of Connecticut School of Medicine, Farmington.
A E
AE
Alsina
L
L
Krisiunas
R J
RJ
Rosenberg
J J
JJ
Sziklas
R T
RT
Schweizer
D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000000981:diagnostic imaging*; D005260:Female; D005334:Fever / Q000209:etiology*; D005710:Gallium Radioisotopes; D006801:Humans; D007205:Indium Radioisotopes; D007962:Leukocytes / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D016377:Organ Transplantation / Q000009:adverse effects*; D011859:Radiography; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013530:Surgical Wound Infection / Q000000981:diagnostic imaging*