Multi-organ procurement utilizing cardiopulmonary bypass and profound hypothermic circulatory arrest.
Despite advances in preservation solutions, hypothermia remains a critical component of organ preservation for transplantation.  Many surgeons involved in multi-organ procurement procedures have expressed concern about the possible detrimental effects of cardiopulmonary bypass and profound hypothermic circulatory arrest on non-thoracic transplant organ function.  In order to assess the validity of these concerns, a review of 20 multi-organ harvest procedures performed utilizing cardiopulmonary bypass and profound hypothermic circulatory arrest was undertaken.  In all instances this technique was combined with organ flushing utilizing cold preservation solution.  Adequate data was available to assess post-transplant organ function of all organs recovered in 16 procedures.  Indication for the use of this technique was procurement of a heart-lung bloc in 16 instances and donor instability (hypotension) refractory to volume loading and inotropic agents in 4 instances.  Organs obtained, including all organs from unstable donors which would otherwise have been lost, functioned, acceptably.  Additionally, blood drained into the pump was used for recipient transfusion in 8 instances.  This report documents that cardiopulmonary bypass and profound hypothermic circulatory arrest may be easily combined with traditional procurement flushing techniques and it provides excellent organ preservation for subsequent transplantation.  This approach can optimize organ recovery from hemodynamically unstable donors, increasing the number available for transplantation.
Department of Surgery and The Multi-Organ Transplant Center, Baylor College of Medicine/The Methodist Hospital, Houston, Texas.
M E
ME
Sekela
J B
JB
Young
H D
HD
Short
H H
HH
Whisennand
G P
GP
Noon
D002315:Cardiopulmonary Bypass / Q000379:methods; D006324:Heart Arrest, Induced / Q000379:methods; D006801:Humans; D009926:Organ Preservation / Q000379:methods*; D016377:Organ Transplantation / Q000379:methods*; D012189:Retrospective Studies; D009927:Tissue and Organ Procurement / Q000379:methods*