Mycosis fungoides--an underwriting prospective with emphasis on staging and risk selection.
Mycosis Fungoides is a T-cell lymphoma having a broad clinical spectrum ranging from localized cutaneous to rapidly fatal systemic disease.  Early clinical presentation is non specific, delaying correct diagnosis.  Compared to clinical, the insurable spectrum is narrow.  Staging for skin, lymph node and other organ manifestations is presented.  Factors which influence mortality within each stage are elucidated.  The survival curves of stages and stage groupings are illustrated and discussed to facilitate risk classification.  Cutaneous (T) and lymph node (LN) stages are the most important prognosticators.  Substages T1/T2, LN1/LN2 without associated palpable adenopathy, eosinophilia, visceral and blood positive findings are insurable.  It would be most appropriate to place them in a tumor class of mild/moderate risk after the initial excessive mortality period ends.  Higher T and LN substages, adenopathy and visceral disease have highly adverse mortality.  These ultimately reveal a flattening of survival curves at 8-10 years.  Although numerous treatment modalities have been used, none appear to consistently prolong life expectancy except in the earliest stage skin disease.
Iacovino
J R
JR
New York Life Insurance Company.
D000206:Actuarial Analysis; D006801:Humans; D007348:Insurance, Health; D009182:Mycosis Fungoides / Q000145:classification / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D009367:Neoplasm Staging / Q000379:methods*; D011446:Prospective Studies; D012878:Skin Neoplasms / Q000453:epidemiology*; D016019:Survival Analysis