Nonsteroidal anti-inflammatory drugs for prevention of heterotopic ossification after total hip arthroplasty.
Nonsteroidal anti-inflammatory drugs (NSAID) have been proven highly effective as prophylaxis for periarticular heterotopic ossification (HO) following total hip arthroplasty (THA) both when given to patients considered to be at risk for this complication, and in consecutive double-blind studies.  Treatment with a standard dosage for 10 days starting on the day of surgery seems to be adequate for the prophylactic effect.  Furthermore, NSAID are effective in preventing recurrence of HO after resection.
Nilsson
O S
OS
Department of Orthopaedics, Uppsala University Hospital, Sweden.
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000009:adverse effects; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D009999:Ossification, Heterotopic / Q000188:drug therapy / Q000517:prevention & control*; D011182:Postoperative Care / Q000379:methods; D011183:Postoperative Complications / Q000188:drug therapy / Q000517:prevention & control*; D012008:Recurrence; D012307:Risk Factors