Predictive value of Doppler ultrasonography in renal transplantation.
During a 17-month period, 268 Doppler sonography studies were performed on 46 consecutive renal transplant patients.  There were 35 episodes of acute rejection in 10 patients, 8 episodes of delayed function and 47 episodes of high cyclosporine levels (greater than 800 ng/dl by TDX method) in 21 patients.  Defining an abnormal resistive index (RI) as greater than 0.8 or a 20% increase above baseline, the test has a specificity of 99% and a sensitivity of 94% in the 1st month post-transplant and had an overall predictive value of 99%.  Episodes of high cyclosporine levels ranging from 800 to 1650 ng/dl did not correlate with a high RI except in one circumstance with concurrent acute rejection.  Within the 1st month post-transplant, only 1 false-negative study occurred.  An additional 8 false-negative studies occurred beyond 1 month post-transplant.  Patients with delayed function are separated into three groups based on the Doppler ultrasounds:  Group I, patients with an accelerated acute rejection with high RI (N = 2); Group II, patients with true ischemic acute tubular necrosis with normal RI (N = 2); and Group III, patients with possible immunologically-mediated delayed function with intermediate RI between 0.6 and 0.8 (N = 4).  Doppler ultrasound is a useful ancillary test to confirm the clinical suspicion of acute rejection.  Since high cyclosporine levels do not cause an increase in RI, Doppler ultrasound may help to avoid confusion between acute rejection and cyclosporine toxicity.  Additionally, this test may offer insight into the cause of early post-transplant renal dysfunction.
Department of Medicine, Baystate Medical Center, Tufts University, School of Medicine, Springfield, MA.
M J
MJ
Germain
G S
GS
Lipkowitz
J
J
Patel
F
F
Hampf
D016572:Cyclosporine / Q000009:adverse effects / Q000627:therapeutic use*; D006084:Graft Rejection / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000517:prevention & control; D006801:Humans; D007165:Immunosuppression Therapy; D007668:Kidney / Q000000981:diagnostic imaging* / Q000187:drug effects; D007674:Kidney Diseases / Q000139:chemically induced / Q000000981:diagnostic imaging*; D016030:Kidney Transplantation / Q000009:adverse effects*; D012680:Sensitivity and Specificity; D014463:Ultrasonography