Clinical insights from the etiopathology of osteoporosis.
Bone resorption may be stimulated by increased parathyroid hormone secretion, certain cytokines, and other bone-resorbing mediators. Low serum calcium levels promote parathyroid hormone secretion, and estrogen deficiency is associated with a rise in cytokine production and activity. An abnormal proliferation of mast cells may also release cytokines, heparin, and other mediators of bone resorption.
Piper
B A
BA
Hospital for Special Surgery, New York City, USA.
Galsworthy
T D
TD
Bockman
R S
RS
D006801:Humans; D010024:Osteoporosis / Q000209:etiology / Q000503:physiopathology*