A clinical evaluation of the effect of calf blood dialysate on the course of acute myocardial infarction.
The effect of daily intravenous treatment for 3 weeks with a calf blood dialysate presumed to improve disturbed oxidative metabolism was compared with placebo in a randomized double-blind study of 60 subjects with a first acute transmural myocardial infarction.  Overall clinical evaluation of initial severity and clinical course suggested a better response of borderline significance in the dialysate-treated group. Blood enzyme elevations were statistically significantly less for that group on day 4 post-infarction for creatine kinase (CK) and aspartate aminotransferase (AspAT) but not for lactate dehydrogenase (LDH). ST segment elevations in the 36 lead ECG developing after admission were fewer in the verum treated than in the placebo group.  Results by each of three criteria (clinical evaluation, enzyme elevations, and electrocardiographic changes) suggest a more favorable response to treatment with the calf blood dialysate as compared to placebo.
Department of Cardiology, Institute of Cardiology, Medical Academy, Kraków, Poland.
K W
KW
Moczurad
M
M
Weiner
W
W
Król
D000183:Actihaemyl / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000818:Animals; D002417:Cattle; D004311:Double-Blind Method; D004562:Electrocardiography / Q000187:drug effects*; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy*