Role of duplex imaging and fine needle aspiration cytology of renal allografts in monitoring response to anti-rejection therapy.
The role of duplex imaging and fine-needle aspiration cytology (FNAC) in monitoring the response to anti-rejection therapy was investigated in 14 of the 22 rejection episodes which occurred in 30 renal allografts recipients.  In 9 of these 14 episodes of rejection, with good resolution, both resistive (RI) and pulsatility (PI) indices decreased by significant proportions (p less than 0.05).  The FNAC scores also fell significantly with anti-rejection therapy.  In 5 other episodes of rejection where the graft continued to deteriorate there was no significant fall of RI and PI (p greater than or equal to 0.2).  In a small group of patients, both FNAC and Doppler predicted rejection.  In conclusion, both duplex imaging and FNAC have a role in selection and optimal modulation of drugs in the treatment of acute renal allograft rejection.
University Department of Surgery and Department of Radiology, St. James's University Hospital, Leeds, U.K.
M R
MR
Rajasekar
J P
JP
Lodge
H C
HC
Irving
G R
GR
Giles
D000293:Adolescent; D000328:Adult; D001707:Biopsy, Needle; D005260:Female; D006084:Graft Rejection / Q000175:diagnosis* / Q000473:pathology / Q000517:prevention & control; D006801:Humans; D007165:Immunosuppression Therapy; D007668:Kidney / Q000000981:diagnostic imaging* / Q000473:pathology; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D014463:Ultrasonography