Viability of platelets collected by apheresis versus the platelet-rich plasma technique: a direct comparison.
Different platelet preparation techniques have not previously been compared directly and simultaneously with respect to in vivo platelet viability.  Using a dual-label technique with 111-In and 114m-In, platelet apheresis was compared with the platelet-rich plasma (PRP) procedure with respect to platelet recovery and survival (n=4).  Furthermore, a continuous flow cell separator (Cobe 2997) and an intermittent apheresis system (Haemonetics V50) were compared with each other (n=4).  No differences in platelet viability were found between the PRP-platelets and the apheresis-platelets.  Also no differences were found between the two apheresis systems.  Although different platelet preparation methods result in a varying degree of platelet activation, no difference in platelet viability has been observed.
Hospital Gelderse Vallei, Department of Internal Medicine, Bennekom, The Netherlands.
R A
RA
de Vries
M
M
de Bruin
J J
JJ
Marx
H C
HC
Hart
A
A
Van de Wiel
D000328:Adult; D001792:Blood Platelets / Q000502:physiology*; D001800:Blood Specimen Collection / Q000379:methods*; D002469:Cell Separation; D002470:Cell Survival; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D008297:Male; D010983:Plateletpheresis / Q000379:methods*