Dosing guidelines for foscarnet and trimetrexate.
The P & T Committee at Trinity Lutheran Hospital, a 320-bed, community/teaching hospital in Kansas City, MO, has developed dosing and monitoring guidelines for foscarnet sodium (Foscavir) and trimetrexate glucuronate (Neutrexin)--two drugs used to treat patients with opportunistic infections associated with the human immunodeficiency virus (HIV). Presented in this Experience Brief is a short discussion of these drugs, the rationale for guideline development, and the actual dosing and monitoring protocols devised.
Trinity Lutheran Hospital, Kansas City, MO, USA.
J M
JM
Wooten
K
K
Chase
M C
MC
O'Connor
R B
RB
Henry
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy*; D002985:Clinical Protocols; D004305:Dose-Response Relationship, Drug; D017245:Foscarnet / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D006745:Hospital Bed Capacity, 300 to 499; D006801:Humans; D008923:Missouri; D008991:Monitoring, Physiologic; D010606:Pharmacy and Therapeutics Committee; D016597:Trimetrexate / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use