Evaluation of leg perfusion during exercise using technetium 99m sestamibi.  A new test for peripheral vascular disease.
Thirty patients with occlusive peripheral vascular disease underwent clinical examination, segmental blood pressure determinations, intra-arterial digital subtraction angiography, and treadmill stress testing with injection of technetium 99m sestamibi at peak exercise. Radionuclide images of the thighs, calves, and feet showed clear delineation of major muscle groups.  Diminished radiotracer distribution was closely correlated with the presence of occlusive vascular disease on angiography and with the presence of claudication and reduced segmental blood pressure.  A quantitative scheme based on pixel intensity was developed to compare areas of regional perfusion.
Milwaukee Heart and Vascular Clinic, The University of Wisconsin-Madison, and St. Luke's Medical Center 53215.
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LS
Wann
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Hellman
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Dorros
D001161:Arteriosclerosis / Q000000981:diagnostic imaging*; D005080:Exercise Test; D006801:Humans; D007866:Leg / Q000098:blood supply* / Q000000981:diagnostic imaging; D016491:Peripheral Vascular Diseases / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D017256:Technetium Tc 99m Sestamibi