Treatment of the transplantable FANFT induced bladder tumors with the purpurin SnET2 and red light emitted by a pulsed frequency doubled Nd:YAG laser.
Photodynamic therapy of transplantable N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide-induced tumors engrafted onto Fischer CDF (F-344)/CrlBR rats that had been sensitized with the photosensitizer tin (ll) etiopurpurin dichloride was performed in combination with visible light (approximately equal to 660 nm) emitted by either a continuous wave argon-dye laser or a pulsed, frequency-doubled Nd:Yag laser.  Tumor control was assessed either by tumor dry-weight 12 days after treatment or by the palpatory absence of tumor at 60 days after treatment.  Both laser sources were effective in creating the desired photodynamic effect.  This study demonstrates the potential for the use of a solid-state pulsed laser for photodynamic therapy when used in combination with the tumor sensitizer tin (ll) etiopurpurin dichloride.
Department of Surgery (Urology), Medical College of Ohio.
S H
SH
Selman
D L
DL
Fitkin
R W
RW
Keck
A R
AR
Morgan
D R
DR
Doiron
D000818:Animals; D005200:FANFT; D006414:Hematoporphyrin Photoradiation / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D053685:Laser Therapy; D009368:Neoplasm Transplantation; D011166:Porphyrins / Q000627:therapeutic use*; D011838:Radiation-Sensitizing Agents; D051381:Rats; D011916:Rats, Inbred F344; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000188:drug therapy*