Peripheral blood stem cell transplantation for breast cancer patients with bone marrow metastases using GM-CSF priming.
Twenty-seven patients with metastastic breast cancer to the bone marrow underwent successful collection of peripheral blood progenitor cells (PBPC) following GM-CSF cytokine priming and were engrafted following courses of high-dose chemotherapy.  Myeloid engraftment was observed in a median of 12 days, with a range of 8-29 days.  The cell dose infused correlated, although weakly, with days to engraftment, although assays of CFU-GM and CD34+ cells did not, suggesting refinement in such assays is needed.  The failure to observe complete remission of the tumor suggests alternative chemotherapy regimens should be investigated.
Department of Hematology, Division of Medicine, University of Texas, M.D. Anderson Cancer Center, Houston 77030.
J P
JP
Hester
R O
RO
Wallerstein
D000328:Adult; D016913:Blood Component Transfusion / Q000379:methods*; D001853:Bone Marrow; D001943:Breast Neoplasms / Q000628:therapy*; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis; D014182:Transplantation, Autologous