Successful treatment of HIV-related vasculitis with peripheral neuropathy with short-term steroids followed by the association of zidovudine and plasmapheresis.
OBJECTIVE
treatment of HIV-related vasculitis, avoiding prolonged immunosuppressive therapy.


METHODS
prospective pilot study of HIV-related neurological vasculitis.


METHODS
two HIV-infected patients with histologically proven vasculitis.


METHODS
short-term corticosteroid followed by zidovudine combined with plasmapheresis.


METHODS
clinical, biological, immunological and electromyographic evaluation.


RESULTS
complete neurological recovery.


CONCLUSIONS
excellent tolerance and efficacy of combined zidovudine and plasmapheresis therapy in peripheral neurological HIV-related vasculitis.
Department of Internal Medicine, Université Paris Nord, Bobigny, France.
P
P
Cohen
L
L
Guillevin
M
M
Gayraud
F
F
Lhote
B
B
Jarrousse
A
A
Leon
R
R
Gherardi
D017088:AIDS-Related Opportunistic Infections / Q000628:therapy*; D000328:Adult; D003131:Combined Modality Therapy; D006679:HIV Seropositivity; D006801:Humans; D008297:Male; D010523:Peripheral Nervous System Diseases / Q000628:therapy; D010956:Plasmapheresis; D011241:Prednisone / Q000627:therapeutic use*; D011446:Prospective Studies; D014657:Vasculitis / Q000628:therapy*; D015215:Zidovudine / Q000627:therapeutic use*