title: Fibrinolysis inhibitors.
abstract: The fibrinolytic system involves a series of enzymatic reactions that results in the conversion of the proenzyme, plasminogen, into the trypsin-like lytic enzyme, plasmin. The major physiologic target of plasmin is fibrin. Free plasmin in plasma is a nonspecific lytic enzyme that will degrade other proteins such as fibrinogen and coagulation factors V and VIII. Plasmin and activators of plasminogen also play a role in ovulation, embryo implantation, tissue remodeling, and inflammation.
authors.affiliation: Medical Technology Program, Michigan State University, East Lansing 48823, USA.
authors.forename: G L
authors.initials: GL
authors.lastname: Davis
mesh_terms: D005260:Female; D005341:Fibrinolysin / Q000037:antagonists & inhibitors; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D010960:Plasminogen Activators; D015849:Plasminogen Inactivators; D011247:Pregnancy / Q000502:physiology; D015843:Serpins / Q000502:physiology*; D013927:Thrombosis / Q000503:physiopathology