title: Long-term performance and wear of ultrahigh-molecular-weight polyethylene in total joint replacement prostheses: a brief overview and perspective.
abstract: Ultrahigh-molecular-weight polyethylene (UHMWPE) is used extensively in total joint replacements, particularly in hip and knee joints. At present, there is extensive concern with the long-term consequences of wear of this material, specifically osteolytic reactions to wear debris. The relationship of wear behavior to polymer morphology is almost completely unknown. Information on the effects of radiation sterilization on crystallinity is available, but gross conflicts exist. A central problem is the release, over long time periods, of huge numbers of submicron particles by wear. It has not been generally recognized that short-term, severe wear and long-term wear of UHMWPE in total joint replacements are very different in character and results. When the long-term wear regime is correctly defined, it is clear that knowledge of the influence of structure and properties on this specific phenomenon is almost completely absent.
authors.affiliation: Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge 02139, USA.
authors.forename: J
authors.initials: J
authors.lastname: Gunther
authors.forename: R M
authors.initials: RM
authors.lastname: Rose
mesh_terms: D006801:Humans; D007595:Joint Prosthesis / Q000009:adverse effects / Q000592:standards; D008422:Materials Testing; D008970:Molecular Weight; D010014:Osteolysis; D011095:Polyethylenes / Q000009:adverse effects / Q000737:chemistry; D011475:Prosthesis Failure; D013997:Time Factors