Laboratory evaluation of a new membrane oxygenator with a built-in hemoconcentrator.
In order to facilitate the handling of cardiopulmonary bypass (CPB) and simplify the circuit, we have developed a new membrane oxygenator with a hemofiltration function. The hollow fiber units for gas exchange and hemofiltration were combined in concentric circles in a cylindrical housing. The total priming volume was 190 ml. Because we used a silicon-coated hollow fiber membrane for gas exchange, this oxygenator was completely resistant to serum leakage. The gas exchange and hemofiltration sections both have a blood-outside flow configuration. All blood flows in a radial direction from around the central core to the surrounding hollow fiber units, first to the hemofiltration portion and then to the gas exchange section. Filtered fluid was easily collected through a stopcock mechanism. The oxygen transfer rate was 312 ml/min at a blood flow rate of 6 L/min, and the ultrafiltration rate was 3.5 L/hour at a blood flow rate of 4 L/min with 25% hematocrit and 200 mmHg transmembrane pressure in an in vitro study. The pressure drop was 62 mmHg at a blood flow rate of 4 L/min. We found no adverse effects in an in vivo study using a mongrel dog. In conclusion, this durable combined device could achieve excellent and simplified hemoconcentration by having all the blood in the unit flow through the hemofiltration portion, and may be useful not only in CPB during open heart surgery, but also in extracorporeal membrane oxygenation.
Nishida
H
H
Department of Cardiovascular Surgery and Cardiopulmonary Bypass, Heart Institute of Japan, Tokyo Women's Medical College, Japan.
Suzuki
S
S
Endo
M
M
Koyanagi
H
H
Kuwana
K
K
Nakanishi
H
H
Aoki
M
M
D000818:Animals; D001775:Blood Circulation; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass / Q000295:instrumentation*; D002417:Cattle; D004285:Dogs; D004867:Equipment Design; D004869:Equipment Safety; D005069:Evaluation Studies as Topic; D015199:Extracorporeal Membrane Oxygenation; D006400:Hematocrit; D006440:Hemofiltration / Q000295:instrumentation*; D018056:Hemorheology; D010100:Oxygen / Q000097:blood; D010107:Oxygenators, Membrane; D012825:Silicon; D013499:Surface Properties