title: A comparative histological study of wound healing following Nd:YAG laser with different energy parameters and conventional surgical incision in rat skin.
abstract: Wound healing following the use of Nd:YAG laser with different frequencies and energy parameters (20 pps and 1.75 W/30 pps and 3.0 W), and the conventional scalpel incision were studied over a period of 4, 7, 14, 21, and 28 days in the rat skin. The low-energy laser wounds could not be significantly differentiated from the conventional incisions although less damage and inflammatory reaction, increased matrix production, and only a little wound contraction could be demonstrated. In the high-energy lased tissues extensive damage and an increased inflammatory reaction were present. The low-energy Nd:YAG and scalpel incisions established a normal wound healing without scar tissue formation compared to the high-energy Nd:YAG, where the necrosis was higher.
authors.affiliation: Department of Prosthodontics, Albert-Ludwigs-University, School of Dentistry, Freiburg, Germany.
authors.forename: G E
authors.initials: GE
authors.lastname: Romanos
authors.forename: S
authors.initials: S
authors.lastname: Pelekanos
authors.forename: J R
authors.initials: JR
authors.lastname: Strub
mesh_terms: D000818:Animals; D062109:Dermatologic Surgical Procedures; D053685:Laser Therapy; D008297:Male; D009354:Neodymium; D051381:Rats; D012867:Skin / Q000473:pathology*; D014945:Wound Healing / Q000502:physiology / Q000528:radiation effects*