Hematopoietic stem cell expansion.
This review addresses two issues: (1) cytokine-mediated expansion of functional end cells for the abrogation of short term neutropenia and thrombopenia following high dose chemotherapy and (2) cytokine-driven increase in absolute numbers of functional stem cells. The literature suggests that the short term exposure of CD34+ cells to cytokines produces mature progenitors which in turn give rise to functional neutrophils and platelets. The expansion of functional stem cells is a more complex issue, as primitive stem cells are quiescent and their growth requirements are less clearly defined.
Rice
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A
Bone Marrow Transplant Laboratory, Children's Cancer Institute Australia.
Ripoche
J
J
Reiers
J
J
D000818:Animals; D018952:Antigens, CD34; D001772:Blood Cell Count; D002454:Cell Differentiation / Q000187:drug effects; D016207:Cytokines / Q000494:pharmacology; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000187:drug effects; D006801:Humans