Making PVC more biocompatible.
Poly(vinyl chloride) (PVC) is used extensively for disposable medical devices. However, it produces adverse reactions when in contact with body tissues and fluids, and can lead to thrombus formation. This article proposes coating material surfaces with synthetic phosphorylcholine-containing polymers to mimic the outer surface of the natural cell membrane. Experimental evidence is provided to support the use of this approach to enhancing the biocompatibility of PVC and other materials.
Yianni
J P
JP
Cardiovascular Division of Biocompatibles Ltd., Uxbridge, UK.
D001672:Biocompatible Materials / Q000009:adverse effects* / Q000737:chemistry; D001777:Blood Coagulation; D002462:Cell Membrane; D004864:Equipment and Supplies / Q000600:supply & distribution; D006801:Humans; D008422:Materials Testing; D010767:Phosphorylcholine / Q000737:chemistry; D011143:Polyvinyl Chloride / Q000009:adverse effects* / Q000737:chemistry; D013499:Surface Properties