title: Using physiologic end points to assess innovations in mechanical ventilation.
abstract: It is our view that new ventilatory methods should be withheld from clinical practice until there has been adequate evaluation of their effect on physiologic variables and the link to long-term outcomes has been established. In the past, premature and over-enthusiastic acceptance of ventilatory strategies may have resulted in patient discomfort and even harm, and this can be minimized by a more careful evaluation of the physiologic effects of such innovations before their acceptance into clinical practice.
authors.affiliation: Stritch School of Medicine of Loyola University of Chicago, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Tobin
authors.forename: A
authors.initials: A
authors.lastname: Jubran
authors.forename: F
authors.initials: F
authors.lastname: Laghi
authors.forename: R
authors.initials: R
authors.lastname: Dhand
mesh_terms: D004059:Diffusion of Innovation; D004417:Dyspnea / Q000503:physiopathology; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000453:epidemiology / Q000503:physiopathology* / Q000628:therapy; D018763:Muscle Fatigue / Q000502:physiology; D017063:Outcome Assessment, Health Care; D011175:Positive-Pressure Respiration; D011659:Pulmonary Gas Exchange / Q000502:physiology; D012119:Respiration / Q000502:physiology; D012121:Respiration, Artificial / Q000639:trends; D012132:Respiratory Muscles / Q000503:physiopathology; D013673:Technology Assessment, Biomedical / Q000379:methods*; D014481:United States / Q000453:epidemiology; D012122:Ventilators, Mechanical / Q000592:standards*