title: Anatomy of intervertebral disc and pathophysiology of herniated disc disease.
abstract: This discussion reviews developments in normal and abnormal disc biology over the past decade. The anatomic and biochemical structure of the disc is reviewed. Emphasis is placed on recent neurochemical changes identified in disc degeneration and disc herniation. Biomechanical considerations for the normal disc are presented. Influence of mechanical factors on disc nutrition, disc degeneration and disc herniation is reviewed. Biologic events underlying the diagnostic methods used in evaluating disorders of the intervertebral disc are presented. The biologic consequences of iatrogenic disc injury in discectomy are also discussed.
authors.affiliation: Department of Orthopaedic Surgery, Harvard Medical School, Beth Israel Hospital, Boston, MA 02215, USA.
authors.forename: S K
authors.initials: SK
authors.lastname: Mirza
authors.forename: A A
authors.initials: AA
authors.lastname: White
mesh_terms: D000293:Adolescent; D000368:Aged; D002648:Child; D006801:Humans; D007403:Intervertebral Disc / Q000033:anatomy & histology*; D007405:Intervertebral Disc Displacement / Q000503:physiopathology*