title: Single donor platelets: can we afford to use them? Can we afford not to use them?
abstract: One of the strategies to reduce the risk of harming a patient by transfusion therapy is to limit the overall risk of transfusion-transmitted disease. Central to this approach is minimizing the number of allogeneic blood products with which a patient is transfused. The usual dose of platelets for an adult patient is either six to 10 random donor platelets vs. one unit of platelets, pheresis (so-called single donor apheresis platelets). Consequently, the transfusion services at the University of Southern California Health Sciences Campus (USC University Hospital, the Norris Cancer Hospital, and Los Angeles County + USC Medical Center) routinely use single donor apheresis platelets (SDPs) rather than random donor platelets (RDPs) in an effort to minimize allogeneic platelet transfusions, and thereby reduce risk of transfusion-transmitted infection. Although there are other compelling medical, technical, and medical-legal reasons to use SDPs instead of RDPs, the authors believe that a decrease in allogeneic donor exposures alone is sufficient reason to make SDPs the platelet component of choice at their institutions.
authors.affiliation: Transfusion Service, University of Southern California (USC) University Hospital, USA.
authors.forename: G
authors.initials: G
authors.lastname: Zeger
authors.forename: C T
authors.initials: CT
authors.lastname: Williams
authors.forename: I A
authors.initials: IA
authors.lastname: Shulman
mesh_terms: D001782:Blood Donors; D003363:Cost Control; D018562:Disease Transmission, Infectious / Q000517:prevention & control*; D006801:Humans; D010983:Plateletpheresis / Q000009:adverse effects / Q000191:economics* / Q000379:methods; D012307:Risk Factors