The economic effects of introducing vigabatrin, a new antiepileptic medication.
Epilepsy is a common disorder, the prevalence of which is estimated at between 0.1 and 1% of the population. Although there are a number of medications available for treating the disorder, 20 to 35% of affected individuals are resistant to standard treatments. Many of these patients could benefit from a new anti-epileptic, vigabatrin. Because the current indication for vigabatrin is as an adjunct in a specific subgroup of epileptic patients, which implies an increased cost of drug therapy, an ex ante economic appraisal of the expected consequences of its introduction in the treatment of epilepsy is valuable. This would provide decision makers with information to complement standard clinical data. Using administrative records of healthcare services utilisation by epileptic patients, we performed a simulation of the expected economic repercussions of vigabatrin use on direct costs related to disease management. The results show that whether or not the introduction of vigabatrin results in an increase or a reduction in costs to the healthcare system depends largely on 3 factors: (i) the administered dosage of vigabatrin; (ii) the effect that vigabatrin has on hospital admissions; and (iii) the proportion of epileptic patients who take the drug. Moreover, this study underlines the usefulness of administrative data in forecasting the economic impact of new health technologies.
Reinharz
D
D
Groupe de Recherche Interdisciplinaire en Santé, Université de Montréal, Québec, Canada.
Kennedy
W
W
Contandriopoulos
A P
AP
Tessier
G
G
Champagne
F
F
D000927:Anticonvulsants / Q000191:economics* / Q000627:therapeutic use; D004827:Epilepsy / Q000188:drug therapy* / Q000191:economics*; D017048:Health Care Costs; D006801:Humans; D018803:Models, Economic; D011792:Quebec; D020888:Vigabatrin; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000191:economics / Q000627:therapeutic use