Reduction in tumor formation on polyethylene by collagen immobilization.
After surface modification with collagen immobilization through covalent binding, porous polyethylene pieces were implanted subcutaneously into the back of rats for 1 year and the tumorigenesis-reducing effect was examined. In the virgin pieces without collagen immobilization, tumors were observed in 11 out of 24 pieces implanted (45.8%). On the other hand, in the collagen immobilized pieces a tumor was found only in one of 24 implanted pieces (4.2%). These results suggest that immobilization of collagen on the surface of an artificial material through covalent binding is very effective for a reduction of tumor formation.
Kinoshita
Y
Y
Second Department of Oral and Maxillofacial Surgery, Kanagawa Dental College, Yokosuka, Japan.
Kuzuhara
T
T
Kobayashi
M
M
Ikada
Y
Y
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced* / Q000473:pathology; D003094:Collagen / Q000378:metabolism; D005549:Foreign-Body Reaction / Q000139:chemically induced* / Q000503:physiopathology; D008297:Male; D011095:Polyethylenes / Q000008:administration & dosage / Q000009:adverse effects* / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors