title: A study of pharmacological vs. pathological autonomic nervous system blockade in humans, using heart rate chaotic dynamics.
abstract: Pathological blocking of the Autonomous Nervous System (ANS) is diagnosed for patients having Autonomic Neuropathy passing a well-defined set of criteria. In this work, It is shown that standard analysis can be complemented by a study of the chaotic dynamics of the Heart Rate (HR), over a period of 12 min in the resting position. It was found that patients who suffering from ANS blockade, typically exhibit a smaller degree of fractality and complexity of the chaotic attractor reconstructed from the time series of the HR signal. These dynamical measures are more evident in normal human subjects that have been subjected to pharmacological ANS blockade.
authors.affiliation: Department of Medical Physics, University of Patras, Greece.
authors.forename: P
authors.initials: P
authors.lastname: Polydoropoulos
authors.forename: T
authors.initials: T
authors.lastname: Bountis
authors.forename: J
authors.initials: J
authors.lastname: Christodoulou
authors.forename: D
authors.initials: D
authors.lastname: Alexopoulos
authors.forename: A
authors.initials: A
authors.lastname: Bezerianos
mesh_terms: D000465:Algorithms; D001285:Atropine / Q000494:pharmacology; D001342:Autonomic Nervous System Diseases / Q000175:diagnosis* / Q000503:physiopathology; D004562:Electrocardiography / Q000187:drug effects; D017709:Fractals; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D017711:Nonlinear Dynamics; D011433:Propranolol / Q000494:pharmacology; D012016:Reference Values; D012021:Reflex, Abnormal / Q000187:drug effects / Q000502:physiology; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted