title: Femoral arterial hemostasis using a collagen plug after coronary artery stent implantation.
abstract: We have investigated the safety and efficacy of sealing the femoral arterial puncture site using purified bovine collagen in the catheter laboratory immediately after coronary stent implantation.  Ten consecutive patients, mean age 64.6 years, pretreated with heparin, aspirin, and dextran underwent the insertion of a collagen plug immediately after coronary stent implantation.  The mean activated clotting time was 512 seconds (range 320-999).  Femoral arterial hemostasis was achieved before leaving the catheterization laboratory in nine of ten patients.  Seven of these patients received additional mild groin compression with an air cushion compression device after hemostasis was successful.  One of ten patients had persistent bleeding after delivery of the collagen plug and later required blood transfusion.  The collagen plug may be a useful adjunct to obtaining hemostasis following coronary stent implantation, but further trials are required to test its reliability in fully anticoagulated patients.
authors.affiliation: Royal Brompton National Heart & Lung Hospital, London, England.
authors.forename: J S
authors.initials: JS
authors.lastname: Gibbs
authors.forename: A K
authors.initials: AK
authors.lastname: Slade
authors.forename: J
authors.initials: J
authors.lastname: Blake
authors.forename: J E
authors.initials: JE
authors.lastname: Nordrehaug
authors.forename: A F
authors.initials: AF
authors.lastname: Rickards
authors.forename: N P
authors.initials: NP
authors.lastname: Buller
authors.forename: U
authors.initials: U
authors.lastname: Sigwart
mesh_terms: D000368:Aged; D000818:Animals; D002404:Catheterization / Q000009:adverse effects; D002417:Cattle; D003094:Collagen / Q000627:therapeutic use*; D003327:Coronary Disease / Q000628:therapy; D004869:Equipment Safety; D005069:Evaluation Studies as Topic; D005260:Female; D005263:Femoral Artery; D006488:Hemostasis, Surgical / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015607:Stents