A new hypothesis of tumorigenesis induced by biomaterials: inhibitory potentials of intercellular communication play an important role on the tumor-promotion stage.
A possible mechanism of tumorigenesis induced by the polyetherurethanes (PEUs) is clarified as follows: the tumor-promoting activities of the PEUs were stronger than the initiating activities; the promotion was facilitated by the polyether soft segment moiety such as poly (tetramethylene oxide) (PTMO), resulting in the inhibition of the gap-junctional intercellular communication; this inhibition was caused by leachable oligomers, degradation, and direct cell/material interaction. On the basis of our recent studies, we also propose a new hypothesis that inhibitory potentials of the intercellular communication play an important role on the tumor-promoting stage in various biomaterials.
Tsuchiya
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T
Division of Medical Devices, National Institute of Health Sciences, Tokyo, Japan.
Nakamura
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A
D001672:Biocompatible Materials / Q000009:adverse effects* / Q000378:metabolism*; D002450:Cell Communication; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced* / Q000378:metabolism; D002478:Cells, Cultured; D006801:Humans; D007365:Intercellular Junctions / Q000378:metabolism*; D011140:Polyurethanes / Q000009:adverse effects* / Q000378:metabolism