title: Protein A immunoadsorption (i.a.) in renal transplantation patients with vascular rejection.
abstract: Vascular rejection after renal transplantation is connected with a higher frequency of allograft dysfunction or graft loss. Plasmapheresis as an adjunctive therapy in the treatment of humoral mediated acute graft rejection was compared with protein A immunoadsorption. Eleven patients with acute graft rejection and high titers of cytotoxic HLA-Ab and/or signs of vascular rejection at graft biopsy (performed in 9 patients) have been treated. Six of them have a stable graft function, the longest graft survival until now is 41 months, four are back on haemodialysis and one patient died from CMV-pneumonia with a stable graft function 9 months after transplantation. We conclude that IA is a useful adjunctive therapy in the treatment of vascular rejection after renal transplantation. Further investigations are necessary to optimize criteria for inclusion.
authors.affiliation: Department of Nephrology, University of Rostock, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Hickstein
authors.forename: G
authors.initials: G
authors.lastname: Korten
authors.forename: R
authors.initials: R
authors.lastname: Bast
authors.forename: D
authors.initials: D
authors.lastname: Barz
authors.forename: R
authors.initials: R
authors.lastname: Templin
authors.forename: J M
authors.initials: JM
authors.lastname: Schneidewind
authors.forename: C
authors.initials: C
authors.lastname: Kittner
authors.forename: H
authors.initials: H
authors.lastname: Nizze
authors.forename: R
authors.initials: R
authors.lastname: Schmidt
mesh_terms: D004730:Endothelium, Vascular / Q000276:immunology*; D005260:Female; D006084:Graft Rejection / Q000276:immunology*; D006801:Humans; D007163:Immunosorbent Techniques; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D013205:Staphylococcal Protein A