A case of idiopathic myelofibrosis with alloimmunization to HLA-identical platelet transfusions not responsive to antibody absorption over protein-A columns.
A case of idiopathic myelofibrosis has been treated with HLA-identical platelet apheresis concentrates. After a short period the patient also developed refractoriness to the haploidentical siblings. Protein A columns were used to absorb the platelet antibodies with no result. Now two apheresis platelet concentrates are used every month, crossmatched negative products produce good results maintaining cell counts between 20 and 30 x 10(9)/L. The immune mechanism involved is difficult to understand.
Menicucci
A
A
Servizio Immunoematologia e Trasfusione, Ospedale Careggi, Firenze, Italy.
Di Pietro
G
G
Venturini
S
S
Avanzi
G
G
D000328:Adult; D016824:Antigens, Human Platelet / Q000276:immunology*; D006680:HLA Antigens / Q000097:blood*; D006801:Humans; D007163:Immunosorbent Techniques; D017713:Platelet Transfusion / Q000009:adverse effects*; D055728:Primary Myelofibrosis / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D013205:Staphylococcal Protein A