Graft T-cell depletion as a prerequisite for the modulation of alloreactivity after haematopoietic stem cell transplantation.
The T-lymphocytes present in the graft, HLA compatibility, and the cytokine environment at the time of transplantation play a major role in alloreactivity. Increased knowledge of the on-going immunological interactions as well as the development of cellular therapy are required to permit further expansion of post-transplantation alloreactivity as an important immunotherapy tool. By allowing successful GvHD prevention and various post-transplantation immunological interventions, T-cell depletion of the graft can be the starting point for a multistage "progressive" procedure transplantation process adapted to recipient disease, HLA compatibility, desired anti-tumour effects and observed alloreactivity.
Tiberghien
P
P
Immuno-Molecular Therapeutics Laboratory, ETS Franche-Comté, Besançon, France.
Hervé
P
P
Cahn
J Y
JY
D000818:Animals; D006084:Graft Rejection / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation; D006650:Histocompatibility Testing; D006801:Humans; D008212:Lymphocyte Depletion; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology; D014184:Transplantation, Homologous