MDIs: physics of aerosol formation.
The aerosol clouds produced by metered dose inhalers are very dynamic and dramatic changes in both droplet size and velocity take place within the first few centimeters of the spray plume. It is the interaction of this dynamic cloud with the geometry of the mouth and oropharynx that controls the extent of oral deposition and hence the ability of the MDI to deliver a respiratory therapeutic to the lung. Oral deposition is controlled by inertial mechanisms and in order to develop meaningful in-vitro test methods consideration must be given to both the velocity and droplet size distribution of the cloud. The correct design of the inlet ports used to convey MDI clouds in aerosol sizing instruments is therefore crucial to the development of successful in-vitro methodologies. The use of large sampling chambers or the characterization of residual aerosol droplets is unlikely to produce meaning product comparisons or satisfactory product control data.
Clark
A R
AR
Genentech, Inc, South San Francisco, CA 94080, USA.
D000280:Administration, Inhalation; D000336:Aerosols; D004867:Equipment Design; D006801:Humans; D009330:Nebulizers and Vaporizers; D010316:Particle Size