Protein A immunoadsorption (i.a.) in renal transplantation patients with vascular rejection.
Vascular rejection after renal transplantation is connected with a higher frequency of allograft dysfunction or graft loss. Plasmapheresis as an adjunctive therapy in the treatment of humoral mediated acute graft rejection was compared with protein A immunoadsorption. Eleven patients with acute graft rejection and high titers of cytotoxic HLA-Ab and/or signs of vascular rejection at graft biopsy (performed in 9 patients) have been treated. Six of them have a stable graft function, the longest graft survival until now is 41 months, four are back on haemodialysis and one patient died from CMV-pneumonia with a stable graft function 9 months after transplantation. We conclude that IA is a useful adjunctive therapy in the treatment of vascular rejection after renal transplantation. Further investigations are necessary to optimize criteria for inclusion.
Hickstein
H
H
Department of Nephrology, University of Rostock, Germany.
Korten
G
G
Bast
R
R
Barz
D
D
Templin
R
R
Schneidewind
J M
JM
Kittner
C
C
Nizze
H
H
Schmidt
R
R
D004730:Endothelium, Vascular / Q000276:immunology*; D005260:Female; D006084:Graft Rejection / Q000276:immunology*; D006801:Humans; D007163:Immunosorbent Techniques; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D013205:Staphylococcal Protein A