Comparison of the standard roller pump and a pulsatile centrifugal pump for extracorporeal circulation during routine coronary artery bypass grafting.
The present prospective study compared the standard nonpulsatile twin roller pump with the Sarns centrifugal pump, in the pulsatile mode, as arterial pumps for extracorporeal circulation during coronary artery bypass grafting (CABG).  The study was conducted in two consecutive groups of 25 patients receiving a standard anaesthetic and surgical protocol.  The investigated parameters included haemodynamic profiles, oxygen exchange, blood gas and acid-base homeostasis, haematology, coagulation and complement consumption.  With comparable settings for pump flow, gas flow and delivered oxygen concentrations, there was no difference between the groups in the main haemodynamic parameters during cardiopulmonary bypass (CPB).  However, a tenfold lower dose of sodium nitroprusside was required to keep systemic vascular resistance within physiologic limits during CPB in the centrifugal group (C group) compared with the roller group (R group).  During rewarming oxygen extraction was higher in the C group than in the R group.  During the first eight hours after CPB no differences in haemodynamics, oxygenation parameters and pulmonary shunt between the groups were observed.  During, as well as after, CPB there was no significant difference in blood gas and acid-base homeostasis between either group. Average postoperative blood loss via chest tubes, total transfusions of blood products, haemoglobin and coagulation did not differ between the two groups.  However, the white blood cell count, corrected for changes in haematocrit, decreased during the early phase of CPB in the R group, but not in the C group.(ABSTRACT TRUNCATED AT 250 WORDS)
Driessen
J J
JJ
Department of Anaesthesiology, St. Jan's Hospital, Brugge, Belgium.
Fransen
G
G
Rondelez
L
L
Schelstraete
E
E
Gevaert
L
L
D000368:Aged; D001158:Arteries / Q000637:transplantation; D001774:Blood Chemical Analysis; D001784:Blood Gas Analysis / Q000706:statistics & numerical data; D002315:Cardiopulmonary Bypass / Q000379:methods; D002498:Centrifugation; D001026:Coronary Artery Bypass; D005112:Extracorporeal Circulation / Q000379:methods; D005260:Female; D006355:Heart-Lung Machine; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009599:Nitroprusside / Q000008:administration & dosage; D011446:Prospective Studies