title: The effects of lactic acid on PGE2 production by macrophages and human synovial fibroblasts: a possible explanation for problems associated with the degradation of poly(lactide) implants?
abstract: The aim of this study was to investigate the effects of lactic acid on cells found at the bone-implant interface in order to try to discover more about the effects of degradation of implants manufactured from poly(lactide). This study shows that human synovial fibroblasts and murine macrophages release prostaglandin E2 (PGE2) a bone resorbing and inflammatory mediator, into the surrounding medium when exposed to lactic acid. The production of PGE2 in response to lactate may help to explain isolated cases of inflammation and discomfort seen some time after fracture fixation with poly(lactide) implants.
authors.affiliation: University of Cambridge Orthopaedic Research Unit, Addenbrookes Hospital, UK.
authors.forename: E
authors.initials: E
authors.lastname: Dawes
authors.forename: N
authors.initials: N
authors.lastname: Rushton
mesh_terms: D000818:Animals; D015232:Dinoprostone / Q000096:biosynthesis*; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D007773:Lactates / Q000493:pharmacokinetics*; D019344:Lactic Acid; D008264:Macrophages / Q000378:metabolism*; D051379:Mice; D011091:Polyesters; D011108:Polymers; D019736:Prostheses and Implants; D013583:Synovial Membrane / Q000378:metabolism*