Extracorporeal granulocytapheresis for cancer and rheumatoid arthritis.
In cancer and rheumatoid arthritis, granulocytosis is often observed and indicates the progress of disease. We developed a granulocytapheresis system to permit granulocyte reduction. Cellulose acetate was found to be a selective and effective adsorbent. In an in vivo study using an acetate bead column, 9.2 x 10(8) leukocytes were collected. Initially, granulocytapheresis was applied to terminal patients or those with stage IV cancer. Pain, cough and bloody sputum were reduced in spite of no decrease in tumor size. Granulocytapheresis appears to prevent inflammatory damage in or around the tumor site. This granulocyte reduction technique was also applied to patients with rheumatoid arthritis. The Lansbury index markedly improved after treatment. As cytokines and adhesion molecules might contribute to symptoms, granulocytapheresis may be useful in improving the "Quality of Life" in these diseases.
Yonekawa
M
M
Department of Surgery, Sapporo Hokuyu Hospital Artificial Organ & Transplantation Hospital, Japan.
Kawamura
A
A
Komai
T
T
Agishi
T
T
Adachi
M
M
D000368:Aged; D000818:Animals; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000628:therapy*; D005260:Female; D006098:Granulocytes / Q000473:pathology; D006801:Humans; D007937:Leukapheresis; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000628:therapy*; D009374:Neoplasms, Experimental / Q000097:blood / Q000628:therapy*