New methods for surface modification and covalent attachment of heparin.
Research is continually under way to improve biocompatibility performance in biomaterials. This article discusses a technique for the covalent attachment of heparin and other drugs onto a variety of polymer and metal surfaces. It offers the potential to improve haemocompatibility and lubricity in a number of medical device applications as well as new drug-delivery systems.
al-Lamee
K
K
PolyBioMed Ltd., Sheffield, UK.
Taktak
Y
Y
D000327:Adsorption; D000925:Anticoagulants / Q000008:administration & dosage / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry*; D001769:Blood; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D016503:Drug Delivery Systems; D004867:Equipment Design; D018056:Hemorheology; D006493:Heparin / Q000008:administration & dosage / Q000737:chemistry*; D006801:Humans; D008153:Lubrication; D008670:Metals / Q000737:chemistry; D010314:Partial Thromboplastin Time; D011108:Polymers / Q000737:chemistry; D013499:Surface Properties; D017155:Wettability; D014914:Whole Blood Coagulation Time