title: The assessment of left ventricular filling dynamics using an online automatic border detection algorithm: comparison with cineventriculography.
abstract: An echocardiographic system has been developed that performs automatic endocardial border detection and instantaneously calculates and displays a waveform of left ventricular cavity area versus time. The purpose of this study was to compare measurements of left ventricular filling dynamics from automatic border detection echocardiography with similar measurements from cineventriculography. Thirty-three patients undergoing cardiac catheterization had automatic border detection echocardiography performed within 45 minutes of cineventriculography. Ten patients had normal catheterization findings and 23 had cardiac disease. The automatic border detection waveforms generated from two echocardiographic views were measured to determine the fraction of filling occurring during the early diastolic rapid filling phase and during the filling phase resulting from atrial contraction. Similar fractions were derived from curves generated from frame-by-frame measurements of cineangiographic volumes. Results were analyzed by correlating echocardiographic and cineventriculographic results, and by a limits of agreement analysis (limits of agreement were +/- 2 standard deviations of the mean difference between echocardiography and cineventriculography). There were significant correlations between echocardiography and cineventriculography for each of the parameters studied. The best results were obtained for the apical four-chamber view (rapid filling fraction r = 0.72, P < 0.0001, atrial filling fraction r = 0.56, P < 0.001). Differences in filling patterns between normal and abnormal patient groups detected by cineventriculography were also detected by automatic border detection echocardiography. However, broad limits of agreement were observed, that may limit the ability of the automatic border detection system to reliably predict cineventriculographic results in an individual patient. Automatic border detection echocardiography can provide information about left ventricular filling dynamics that is similar to that obtained from frame-by-frame analysis of cineventriculograms. However, the variability in the results may limit the application of the technique in individual patients.
authors.affiliation: Division of Cardiology, University of Kentucky Medical Center, Lexington 40536, USA.
authors.forename: P M
authors.initials: PM
authors.lastname: Sapin
authors.forename: O L
authors.initials: OL
authors.lastname: Kwan
authors.forename: G Y
authors.initials: GY
authors.lastname: Xie
authors.forename: M D
authors.initials: MD
authors.lastname: Smith
authors.forename: A N
authors.initials: AN
authors.lastname: DeMaria
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D006328:Cardiac Catheterization; D002306:Cardiac Volume / Q000502:physiology*; D002637:Chest Pain / Q000000981:diagnostic imaging*; D002933:Cineradiography / Q000379:methods; D004452:Echocardiography / Q000379:methods; D005260:Female; D006439:Hemodynamics; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016277:Ventricular Function, Left / Q000502:physiology