title: Proinflammatory mediator response in coronary bypass surgery using a centrifugal or a roller pump.
abstract: Major surgery, trauma, and infection induce a proinflammatory mediator response which, if excessive, may cause tissue injury. The response was measured during elective coronary bypass surgery when a centrifugal pump or a roller pump, differing in their basic working principles, was used for extracorporeal circulation (ECC). Eight patients were perfused with a centrifugal pump and eight patients with a roller pump during ECC. Plasma interleukin-1 beta (IL-1 beta), IL-2, IL-6, tumor necrosis factor alpha (TNF alpha), group II phospholipase A2, (PLA2), endotoxin, fibronectin and serum C-reactive protein (CRP) concentrations were measured. The operation increased plasma IL-6, group II PLA2, and serum CRP concentration and decreased plasma fibronectin concentrations. IL-1 beta and TNF alpha concentrations did not change. IL-2 occurred only occasionally, and endotoxin did not occur in any patient. No differences were seen between the group using a centrifugal pump and the group using the roller pump. Cardiac surgery with a perfusion time of less than two hours thus caused a proinflammatory mediator response which was similar whether a centrifugal or a roller pump was used for ECC.
authors.affiliation: Department of Anaesthesiology, University of Turku, Finland.
authors.forename: M
authors.initials: M
authors.lastname: Sao
authors.forename: J
authors.initials: J
authors.lastname: Perttilä
authors.forename: K
authors.initials: K
authors.lastname: Pulkki
authors.forename: J
authors.initials: J
authors.lastname: Grönroos
authors.forename: J
authors.initials: J
authors.lastname: Mertsola
authors.forename: O
authors.initials: O
authors.lastname: Peltola
authors.forename: T
authors.initials: T
authors.lastname: Nevalainen
mesh_terms: D002315:Cardiopulmonary Bypass / Q000009:adverse effects* / Q000295:instrumentation*; D001026:Coronary Artery Bypass; D016207:Cytokines / Q000097:blood*; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D010741:Phospholipases A / Q000097:blood; D054467:Phospholipases A2; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism