Non-invasive magnetic resonance imaging of the soft tissue response to a biomaterial.
Magnetic resonance imaging (MRI) has been employed to visualize the tissue response to hydrogel implants in rats.  High contrast MR images of the implant site were obtained.  Distinct tissue variations in the MR images have been observed.  These can be attributed to either the surgical procedure or the application of a tissue irritant to produce inflammation and have been verified histologically.  This study demonstrates that MRI is potentially a useful tool for the non-invasive in-vivo evaluation of biomaterials.
Khor
E
E
Department of Clinical Engineering, University of Liverpool, UK.
Hunt
J A
JA
Martin
P A
PA
Doherty
P J
PJ
Williams
R L
RL
Williams
D F
DF
D000818:Animals; D003238:Connective Tissue / Q000276:immunology / Q000503:physiopathology*; D005069:Evaluation Studies as Topic; D005549:Foreign-Body Reaction / Q000175:diagnosis; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008422:Materials Testing; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000493:pharmacokinetics / Q000627:therapeutic use; D019736:Prostheses and Implants; D011919:Rats, Inbred Strains