Tricalcium phosphate as a bone graft substitute.
A clinical trial is reported that was conducted in an attempt to establish a timeframe for replacement of tricalcium phosphate by bone. In 20 cases, an 8.5mm by 3mm disc of tricalcium phosphate was implanted into the cut surface of the tibia at the time of total knee replacement.  When followed radiographically, the disc of tricalcium phosphate generally could not be identified at six months.  At two years, no untoward effects have occurred and no vestigial shadows remain, indicating that the block has fully incorporated and largely been absorbed and replaced by host bone.  The experience in this series of cases indicates that tricalcium phosphate is a useful resorbable bone filler material.
Cameron
H U
HU
Department of Surgery, University of Toronto, Ontario, Canada.
D000368:Aged; D001861:Bone Regeneration / Q000502:physiology; D002130:Calcium Phosphates / Q000627:therapeutic use*; D005260:Female; D006085:Graft Survival; D006801:Humans; D007720:Knee Prosthesis / Q000295:instrumentation / Q000379:methods; D008297:Male; D008422:Materials Testing; D019736:Prostheses and Implants; D013977:Tibia / Q000254:growth & development / Q000601:surgery; D013997:Time Factors