title: Biostable polyurethane elastomers.
abstract: The generic term polyurethane represents the most versatile family of synthetic polymers.  The unsurpassed physical and chemical properties of polyurethanes, coupled with their biocompatibility, have led to their use in a wide range of biomedical applications.  Although polyurethanes have been shown to be stable in vitro for many years, they can undergo rapid microcracking when implanted.  These microcracks not only weaken the polymer but also serve as nucleation sites for thrombus formation and lead to catastrophic failure.  In this article, the authors report on the development and testing of a new ether-free polyurethane that does not exhibit surface microcracking under accelerated in vivo condition.
authors.affiliation: PolyMedica Industries, Inc., Woburn, Massachusetts 01801.
authors.forename: M
authors.initials: M
authors.lastname: Szycher
authors.forename: A M
authors.initials: AM
authors.lastname: Reed
mesh_terms: D000818:Animals; D001673:Biodegradation, Environmental; D005260:Female; D006801:Humans; D008422:Materials Testing; D011140:Polyurethanes / Q000009:adverse effects / Q000737:chemistry*; D019736:Prostheses and Implants / Q000009:adverse effects; D011817:Rabbits; D012408:Rubber; D013314:Stress, Mechanical; D013718:Tensile Strength