An integrated model of sleep regulation.
We present a new model of sleep regulation which integrates the two process model and the limit cycle reciprocal interaction model. In the two process model the interaction of a homeostatic process (S signal) and of a circadian process determines the timing of sleep and waking. In the limit cycle model, the NREM-REM sleep cycle is generated by the reciprocal interaction of two coupled cell population. The present model integrates the two considered models introducing the trigger REM-NREM generated by the REM-ON signal and activated when REM-ON overcomes the S signal.
Ruggiero
C
C
DIST, Department of Communications Computer and System Sciences, University of Genova, Italy.
Giacomini
M
M
Schiavi
G
G
Nobili
L
L
Ferrillo
F
F
D002540:Cerebral Cortex / Q000503:physiopathology; D002940:Circadian Rhythm / Q000502:physiology*; D003198:Computer Simulation; D004569:Electroencephalography; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D009290:Narcolepsy / Q000175:diagnosis / Q000503:physiopathology; D017286:Polysomnography; D012016:Reference Values; D012815:Signal Processing, Computer-Assisted; D012894:Sleep Stages / Q000502:physiology*; D012895:Sleep, REM / Q000502:physiology*