title: Osteoconduction of bioceramics in normal and osteopenic rats: comparison between bioactive and bioinert ceramics.
abstract: Rats with experimental osteopenia, which was induced by resecting both ovaries and sciatic nerves (OVX + NX), were used to evaluate osteoconduction of an apatite and wollastonite-containing glass-ceramic (designated A-W.GC) and an alumina ceramic.  The bone mineral densities (BMDs) of the femurs were measured by dural energy X-ray absorptiometry (DEXA) and determination of the ash weight.  Twelve weeks after the first operation, when the BMDs in the OVX + NX groups were about 20% less than that in the sham-treated groups (Sham), the bioceramics were implanted into the proximal tibiae.  The bone mineral masses around the implants in the proximal tibiae were evaluated by histological examination of undecalcified specimens and DEXA.  Both types of implants in the OVX + NX groups showed less reactive bone than those in the Sham groups.  However, a histomorphological study revealed that the direct contact area between bone and implant was larger with bioactive ceramic A-W.GC than with the bioinert alumina ceramic even under osteopenic conditions while two types of ceramic made no difference on the bone at distance from the implant.  The direct contact area with A-W.GC did not show any difference between the Sham and the osteopenic OVX + NX groups.  The bioactive ceramic A-W.GC appears to have good osteoconductivity solely on its surface even under osteopenic conditions.
authors.affiliation: Department of Orthopaedic Surgery, Faculty of Medicine, Kyoto University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Iwashita
authors.forename: T
authors.initials: T
authors.lastname: Yamamuro
authors.forename: R
authors.initials: R
authors.lastname: Kasai
authors.forename: T
authors.initials: T
authors.lastname: Kitsugi
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: H
authors.initials: H
authors.lastname: Okumura
authors.forename: T
authors.initials: T
authors.lastname: Kokubo
mesh_terms: D000537:Aluminum Oxide; D000818:Animals; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000601:surgery*; D002516:Ceramics; D005260:Female; D005269:Femur / Q000601:surgery; D005898:Glass; D008422:Materials Testing; D019736:Prostheses and Implants; D051381:Rats; D017208:Rats, Wistar; D012824:Silicic Acid