The toxicology of mitomycin C on the ciliary body.
Over the past few years, the use of mitomycin C (MMC) to reduce surgical failures following filtering procedures has largely increased. After topical application, significant amounts of MMC can be detected intraocularly. In both rabbit and human eyes, a reduction of the normal and elevated intraocular pressures could be achieved with subconjunctival injections of MMC without filtering procedures. Histopathologic examination of the ciliary body in a human eye shortly after surgery with MMC revealed moderate, diffuse toxic changes of the two layers of the ciliary epithelium. By fluorophotometry, eyes after trabeculectomy with MMC had a decreased production of aqueous humor compared with eyes that underwent trabeculectomies without antimetabolites. Independent studies suggest that the toxicity of MMC for the ciliary epithelium may be a significant factor contributing to postoperative hypotony.
Mietz
H
H
Department of Ophthalmology, University of Cologne, Germany.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D001082:Aqueous Humor / Q000378:metabolism; D002924:Ciliary Body / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D003228:Conjunctiva / Q000187:drug effects / Q000473:pathology; D018463:Filtering Surgery; D005901:Glaucoma / Q000473:pathology / Q000601:surgery; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D016685:Mitomycin / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity*; D011817:Rabbits; D012590:Sclera / Q000187:drug effects / Q000473:pathology