title: A comparison of peripheral blood stem cell apheresis using the Fenwal CS3000 Plus and COBE Spectra.
abstract: We have compared the leukapheresis products collected on the Fenwal CS3000 Plus and COBE Spectra in a well-controlled patient population. While statistically significant differences were found, i.e. in product hematocrit, volume, number of granulocytes and platelets collected, these are not felt to be physiologically important. Similar efficiency in collecting mononuclear cells and colony forming unit assay results indicate that each instrument is capable of harvesting hematopoietic progenitor cells from peripheral blood.
authors.affiliation: Department of Pathology, Wayne State University Medical School, Detroit, MI 48201, USA.
authors.forename: J S
authors.initials: JS
authors.lastname: Dzieczkowski
authors.forename: M
authors.initials: M
authors.lastname: McGonigal
authors.forename: J
authors.initials: J
authors.lastname: Cook
authors.forename: M
authors.initials: M
authors.lastname: Sugrue
authors.forename: J
authors.initials: J
authors.lastname: Andersen
authors.forename: K C
authors.initials: KC
authors.lastname: Anderson
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001772:Blood Cell Count; D001943:Breast Neoplasms / Q000097:blood / Q000628:therapy; D016190:Carboplatin / Q000008:administration & dosage; D003114:Colony-Forming Units Assay; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use; D006400:Hematocrit / Q000295:instrumentation* / Q000379:methods; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells; D006801:Humans; D007937:Leukapheresis / Q000295:instrumentation* / Q000379:methods; D008408:Mastectomy; D008875:Middle Aged; D013852:Thiotepa / Q000008:administration & dosage