The red cell storage lesion and its implication for transfusion.
Storage of red blood cells in preservative medium is associated with metabolic, biochemical and molecular changes to erythrocytes collectively referred to as the "storage lesion." In addition to corpuscular injury, bioreactive substances including cytokines and lipids accumulate in the medium during storage. We review evidence for those storage related changes and potential clinical implications for red blood cell transfusion.
Chin-Yee
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I
Department of Haematology, London Health Sciences Centre, University of Western Ontario, Canada. icyee@lhsc.on.ca
Arya
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N
d'Almeida
M S
MS
D001793:Blood Preservation; D001803:Blood Transfusion; D004912:Erythrocytes / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007962:Leukocytes / Q000502:physiology; D015227:Lipid Peroxidation / Q000502:physiology; D010100:Oxygen / Q000097:blood; D010743:Phospholipids / Q000097:blood