title: Scientific assay methods as the basis for glove selection.
abstract: Allergies to latex proteins and glove chemicals are increasing in the clinical practice setting. Inasmuch as latex is ubiquitous in the health environment, individuals may be exposed to latex antigens by a number of different routes, including compromised skin, mucous membranes of the respiratory and urogenital tracts, and internally during surgery. As demonstrated by numerous research articles, the key factors that appear to play a role in acquired latex hypersensitivity are chemicals used in the manufacture of products; the level of residual latex proteins, and the presence of glove powder, which binds latex protein. Currently, devices and materials containing latex are not labeled, although this may be rectified by the FDA in the near future. Until products are labeled, it is important for physicians to familiarize themselves with the routes of sensitization, variations in assay methods, and the type and amount of allergen in products in order to select the safest product for patient use and personal protection.
authors.affiliation: Guthrie Foundation for Medical Research, Sayre, PA 18840-1692, USA.
authors.forename: D H
authors.initials: DH
authors.lastname: Beezhold
authors.forename: M F
authors.initials: MF
authors.lastname: Fay
authors.forename: G L
authors.initials: GL
authors.lastname: Sussman
mesh_terms: D000595:Amino Acid Sequence; D003257:Consumer Product Safety; D017575:Gloves, Protective / Q000009:adverse effects* / Q000592:standards* / Q000600:supply & distribution; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology / Q000517:prevention & control*; D007840:Latex / Q000009:adverse effects*; D008422:Materials Testing / Q000379:methods*; D008969:Molecular Sequence Data; D011852:Radioallergosorbent Test; D014481:United States; D014486:United States Food and Drug Administration