Development and evaluation of a pulsed nebulizer with predictable dosing characteristics.
A metered dose nebulizer assembly with the capability for repeatable doses is described, comprising a commercial disposable nebulizer and a timing circuit to control the duration of air supply. Data on performance of the nebulizer apparatus under typical operating conditions are presented, using cromolyn sodium as a model compound. Repeat doses from the apparatus typically show less than 10% relative standard deviation.
Miller
N C
NC
Inhalation Technology Laboratory, 3M Pharmaceuticals, St. Paul, MN 55144, USA.
Morken
M A
MA
Schultz
R K
RK
D000336:Aerosols; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004205:Cromolyn Sodium / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004209:Disposable Equipment; D004867:Equipment Design; D006801:Humans; D008422:Materials Testing; D009330:Nebulizers and Vaporizers / Q000145:classification / Q000592:standards* / Q000600:supply & distribution; D011673:Pulsatile Flow; D013997:Time Factors