Technical and clinical experience with protein A immunoadsorption columns.
Protein A adsorption (Immunosorba, Excorim, Sweden) is a potent tool for the rapid removal of antibodies from the circulation. In comparison to conventional plasma exchange therapy, Protein A adsorption offers the advantage of processing large amounts of plasma, removing up to 87% of the initial level of IgG in one session without a clinically significant loss of fibrinogen. So far 61 treatments have been carried out in our department without serious side effects.
Belàk
M
M
Borberg
H
H
Jimenez
C
C
Oette
K
K
D001781:Blood Component Removal / Q000379:methods*; D002846:Chromatography, Affinity; D002850:Chromatography, Gel; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D007163:Immunosorbent Techniques; D010951:Plasma Exchange; D013205:Staphylococcal Protein A