The effects of oligomers content and surface morphology on foreign-body tumorigenesis with polyetherurethanes: two years subcutaneous implantation study in rats.
Three polyurethane materials were prepared by removing and adding the leachable oligomers from and to the same polyetherurethane (PEU). The three PEU materials were dissolved in tetrahydrofuran (THF) and dimethyformamide (DMF) and the solutions were cast on a glass plate to make films of smooth and foamed surfaces, respectively. These six materials and polydimethylsioxane (silicone) were implanted into subcutaneous pocket of rats for 2 years to evaluate the long-term effects around the implant. Among the smooth surface implants, PEU materials induced a higher incidence of tissue responses, including tumor formation than silicone. However, no relationship between the oligomer content and the tissue responses was found. Changing surface morphology from a smooth to a foamed one prolonged the latent period of tumor development and decreased the total tumor incidence.
Nakamura
A
A
National Institute of Health Sciences, Tokyo, Japan.
Kojima
S
S
Isama
K
K
Umemura
T
T
Kawasaki
Y
Y
Takada
K
K
Tsuda
M
M
Kurokawa
Y
Y
D000704:Analysis of Variance; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced* / Q000473:pathology; D016009:Chi-Square Distribution; D005549:Foreign-Body Reaction / Q000209:etiology* / Q000473:pathology; D008297:Male; D011140:Polyurethanes / Q000008:administration & dosage / Q000009:adverse effects* / Q000737:chemistry; D019736:Prostheses and Implants / Q000009:adverse effects; D051381:Rats; D017208:Rats, Wistar; D012828:Silicones / Q000008:administration & dosage / Q000009:adverse effects* / Q000737:chemistry; D013997:Time Factors