title: Comparative clinical studies of platelet concentrates: effects on clinical outcome and the use of healthcare resources. NBS Platelet Study Group.
abstract: The Platelet Study Group are developing proposals to conduct a prospective randomised trial of different platelet products in the transfusion support of patients with haematological malignancy. All patients will receive prestorage leucodepleted red cells and will be randomised to receive either multiple donor non-apheresis buffy coat platelets which are non-leucodepleted (BCP), single donor apheresis platelets non-leucocyte depleted (SDP) or single donor (LD-SDP). All leucocyte depleted products will contain fewer than 5 x 10(6) WBC/transfusion. The primary objective of the study is to compare clinical efficacy, the incidence of adverse reactions treatment outcome and the use of healthcare resources.
authors.affiliation: Bristol Institute of Transfusion Sciences, U.K.
authors.forename: D H
authors.initials: DH
authors.lastname: Pamphilon
mesh_terms: D000328:Adult; D001781:Blood Component Removal; D006801:Humans; D007938:Leukemia / Q000628:therapy*; D009101:Multiple Myeloma / Q000628:therapy*; D017713:Platelet Transfusion / Q000009:adverse effects / Q000379:methods; D016896:Treatment Outcome