On the use of primary reference grade polydimethylsiloxane.
There has been an increase in the use of primary reference material as a standard for identifying the cellular response to biomaterials.  One such material is NHLBI-DTB polydimethylsiloxane (PDMS).  The PDMS was developed for blood contacting studies and is composed of PDMS backed on one side with mylar.  The results of implantation studies of two different publications are discussed in light of the different materials and different surface topographies of each of the materials.  The appropriateness of in vivo studies using this reference material is questioned.
Schmidt
J A
JA
Department of Bioengineering, Clemson University, South Carolina 29634.
von Recum
A F
AF
D004129:Dimethylpolysiloxanes / Q000592:standards*; D006801:Humans; D007111:Immunity, Cellular; D008422:Materials Testing; D008857:Microscopy, Interference; D011093:Polyethylene Terephthalates / Q000592:standards*; D019736:Prostheses and Implants / Q000592:standards; D012015:Reference Standards; D013499:Surface Properties; D014481:United States