title: Histological and histomorphometrical evaluation of the bone reaction to three different titanium alloy and hydroxyapatite coated implants.
abstract: The aim of this study was to investigate the bone response to three different types of titanium (Ti) alloys and hydroxyapatite (HA) coated titanium alloy by histological and histomorphometrical analysis. Therefore, implants made of these materials were inserted into the tibia of rabbits.  Implantation times were 6 and 16 weeks.  The histological evaluation included measurement of the amount of bone apposition and analysis of the bone reaction and interface characteristics around the implants.  The results demonstrated no marked differences in bony reaction to the different implant materials.  In addition, the HA coatings showed loss of thickness.
authors.affiliation: Department of Oral Function and Prosthetic Dentistry, Dental School, University of Nijmegen, The Netherlands.
authors.forename: J A
authors.initials: JA
authors.lastname: Jansen
authors.forename: J P
authors.initials: JP
authors.lastname: van der Waerden
authors.forename: J G
authors.initials: JG
authors.lastname: Wolke
mesh_terms: D016723:Bone Remodeling; D006801:Humans; D006882:Hydroxyapatites / Q000009:adverse effects; D008422:Materials Testing / Q000379:methods; D019736:Prostheses and Implants; D013499:Surface Properties; D013977:Tibia / Q000033:anatomy & histology; D014025:Titanium / Q000009:adverse effects; D014961:X-Ray Diffraction