title: Annexin V, a new marker of platelet storage lesion: correlation with dMPV.
abstract: Released annexin V, an intracellular platelets glycoprotein, was used to determine the cellular injury which occurred during storage of platelet concentrates. Twenty-eight units of leuco-reduced apheresis platelet concentrates, obtained without leucocyte filtration, were analysed. Released annexin V showed a significant correlation with EDTA-induced shape changes of platelet (r = 0.62, P < 0.01) while poor correlation was found between released annexin V and pH or MPV. The combination of released annexin V with dMPV provides excellent markers of the platelet storage lesion for quality monitoring, based on morphological/functional integrities and cellular injury, which are of direct relevance to clinical efficacy of platelet concentrates.
authors.affiliation: National Blood Service-North London, UK.
authors.forename: P
authors.initials: P
authors.lastname: Krailadsiri
authors.forename: J
authors.initials: J
authors.lastname: Seghatchian
authors.forename: J
authors.initials: J
authors.lastname: Amiral
authors.forename: A M
authors.initials: AM
authors.lastname: Vissac
authors.forename: M
authors.initials: M
authors.lastname: Contreras
mesh_terms: D017304:Annexin A5; D015415:Biomarkers; D001792:Blood Platelets / Q000502:physiology*; D001793:Blood Preservation; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010976:Platelet Count; D017713:Platelet Transfusion