Publication bias in clinical trials and economic analyses.
Publication bias is an established notion in the clinical literature; essentially, large studies or positive results are more likely to find their way into the public domain than small studies or negative results. Meta-analysis presents a focus for the problems of publication bias, seeking to summarise the evidence in a particular therapeutic area by retrieving and analysing all available clinical studies. Economic analyses are also vulnerable to publication bias, and at 3 levels: first, in the health-outcomes data available for modelling (resulting from publication bias in the clinical literature); second, in the motivations for conducting an economic analysis; and third, in repeating the process of seeking publication.
Freemantle
N
N
Centre for Health Economics, University of York, England. nf2@york.ac.uk
Mason
J
J
D002986:Clinical Trials as Topic; D003362:Cost-Benefit Analysis; D004656:Enalapril / Q000009:adverse effects; D017594:Publication Bias