Incidence of electrocardiographic changes during cytapheresis using an intermittent flow centrifuge, haemonetics V50 and a continuous flow centrifuge, AS104.
Electrocardiographic (ECG) monitoring was performed during cytapheresis and the incidence of ECG changes was compared between methods of intermittent flow centrifugation using the Haemonetics V50 with apheresis donors and continuous flow centrifugation with the AS104 for peripheral blood stem cell (PBSC) collection from patients. ST depression, inverted T wave and other ECG changes were found in 49 (14.3%) of the 342 cytaphereses carried out by the intermittent flow centrifugation method and in 8 (4.7%) of the 169 PBSC collections by the continuous flow centrifugation method. This difference was significant (P < 0.05). The hemodynamic changes in the procedure with the AS104 seem to be small. This is considered to be important for prevention of serious ST and T wave changes.
Komatsu
F
F
Blood Transfusion Service, School of Medicine, Tokyo Medical and Dental University, Japan.
Kajiwara
M
M
D001781:Blood Component Removal / Q000009:adverse effects* / Q000379:methods*; D002498:Centrifugation / Q000295:instrumentation / Q000379:methods; D004562:Electrocardiography; D006321:Heart / Q000502:physiology; D006801:Humans