title: Double-lumen inferior vena cava catheters for peripheral stem cell apheresis and transplantations.
abstract: No previously published studies have described double-lumen hemodialysis/apheresis catheters for use with continuous-flow apheresis collection of peripheral stem cell (PSC). We prospectively evaluated experiences with these catheters during both PSC collection and transplantation. Because of previously-described successful experiences with single-lumen apheresis catheters placed in the inferior vena cava, all catheters evaluated in this study were placed in this anatomic location. Our experience demonstrated high rates of thrombotic occlusion (65%) and catheter-related infections (15%). This method of access should not be considered optimal in its present state of use. Further investigation into preferred catheter design, anatomic location, and thrombosis prophylaxis during continuous-flow apheresis is warranted.
authors.affiliation: Department of Internal Medicine, University of Nebraska Medical Center, Omaha 68198-1210, USA.
authors.forename: W D
authors.initials: WD
authors.lastname: Haire
authors.forename: L C
authors.initials: LC
authors.lastname: Stephens
authors.forename: G D
authors.initials: GD
authors.lastname: Kotulak
authors.forename: K
authors.initials: K
authors.lastname: Schmit-Pokorny
authors.forename: A
authors.initials: A
authors.lastname: Kessinger
mesh_terms: D000328:Adult; D000368:Aged; D001241:Aspirin / Q000627:therapeutic use; D016470:Bacteremia / Q000209:etiology; D002405:Catheterization, Central Venous / Q000009:adverse effects / Q000295:instrumentation*; D004867:Equipment Design; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000295:instrumentation*; D006412:Hematopoietic Stem Cells; D006801:Humans; D007937:Leukapheresis / Q000295:instrumentation*; D015993:Life Tables; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood / Q000628:therapy; D013927:Thrombosis / Q000209:etiology / Q000517:prevention & control; D016896:Treatment Outcome; D014682:Vena Cava, Inferior