Chronic inflammatory demyelinating polyradiculoneuropathy: superiority of protein A immunoadsorption over plasma exchange treatment.
We present a patient with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) who was treated regularly with plasma exchanges (PE) because response to other therapies including i.v. immunoglobulins was not adequate. To reduce nonspecific protein losses due to repeated PE and increase IgG-removal, immunoadsorption (i.a.)-therapy using sepharose-bound protein A was initiated. Retrospective analysis of clinical data including muscle strength and walking distance shows that IA led to more rapid and greater functional improvement than PE in this patient with no relevant side effects. After 3 years of therapy lymphoma was diagnosed and treated. The patient had no relapses of CIDP for 17 months, when his functional status deteriorated again necessitating further IA-therapy. It is concluded that IgG removal by IA in CIDP is more effective and has fewer complications than PE. Due to the chronic course of CIDP requiring repeated interventions IA is also not more expensive than PE.
Ullrich
H
H
Department of Clinical Chemistry, University Hospital of Regensburg, Germany.
Mansouri-Taleghani
B
B
Lackner
K J
KJ
Schalke
B
B
Bogdahn
U
U
Schmitz
G
G
D002908:Chronic Disease; D003711:Demyelinating Diseases / Q000150:complications / Q000628:therapy*; D006801:Humans; D007163:Immunosorbent Techniques; D008297:Male; D010951:Plasma Exchange; D011115:Polyneuropathies / Q000150:complications / Q000628:therapy*; D013205:Staphylococcal Protein A