[Rapidly progressive irradiated cervical cancer that metastasized to the liver during therapy for idiopathic thrombocytopenic purpura].
A 37-year-old woman was given a diagnosis of cervical cancer in August 1994. Because of severe thrombocytopenia, she was given radiation therapy at 50 Gy with great effectiveness. The thrombocytopenia was diagnosed as idiopathic thrombocytopenic purpura. Because the patient refused to undergo a splenectomy operation, she was treated with prednisolone, gamma-globulin, and danazol with no effect. In January 1995 she began receiving azathioprine and her platelet count gradually increased. In March, she complained of severe left abdominal pain but abdominal computed tomography (CT) scans showed no abnormal findings. Nonetheless, the patient's lumbago persisted and her liver dysfunction was progressive. Abdominal CT scans performed on April 18 disclosed multiple liver tumors. The patient died on April 28. Autopsy revealed that the cervical cancer was the primary origin of the liver tumors. We concluded that extra precautions should be taken when administering immunosuppressive therapy to patients with a history of malignant diseases.
Yoshimura
T
T
First Department of Internal Medicine, Hirosaki University School of Medicine.
Tamai
Y
Y
Takami
H
H
Kariya
K
K
Nakahata
R
R
Tsushima
K
K
Munakata
A
A
Kawamura
S
S
D000328:Adult; D001379:Azathioprine / Q000009:adverse effects*; D002294:Carcinoma, Squamous Cell / Q000556:secondary*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008113:Liver Neoplasms / Q000556:secondary*; D008207:Lymphatic Metastasis; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000188:drug therapy*; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000532:radiotherapy
D007166:Immunosuppressive Agents; D001379:Azathioprine