Inhibitory effect of green and black tea on tumor growth.
The administration of green tea, black tea, or (-)-epigallocatechin gallate inhibited the growth of established nonmalignant and malignant tumors in tumor-bearing mice. In experiments with black tea, we found that its oral administration inhibited DNA synthesis and enhanced apoptosis in both nonmalignant and malignant tumors in tumor-bearing mice.
Conney
A H
AH
Laboratory for Cancer Research, Department of Chemical Biology, College of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854-8020, USA.
Lu
Y
Y
Lou
Y
Y
Xie
J
J
Huang
M
M
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002392:Catechin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004261:DNA Replication / Q000187:drug effects; D004273:DNA, Neoplasm / Q000187:drug effects; D051379:Mice; D009374:Neoplasms, Experimental / Q000473:pathology / Q000517:prevention & control*; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D013662:Tea / Q000627:therapeutic use*
D004273:DNA, Neoplasm; D010936:Plant Extracts; D013662:Tea; D002392:Catechin; C045651:epigallocatechin gallate