[Individual resistance of the cardiovascular system to acute hemorrhage].
Monitoring by ultrasonic and laser Doppler flowmetry and biomicroscopy demonstrated that rats highly resistant to acute blood loss differ in principle from rats with low resistance by the life span, pattern of changes in arterial pressure, organ hemodynamics, and microcirculation. The pumping function of the heart is intact till the end of life in all highly resistant and in 65% poorly resistant rats. After arrest of massive hemorrhage, 35% poorly resistant animals develop low cardiac output syndrome. Poorly resistant rats with severe posthemorrhagic hypotension represent a risk group in need of special pathogenetic therapy.
Kovalenko
N Ia
NIa
Matsievskiĭ
D D
DD
Arkhipenko
Iu V
IuV
D000208:Acute Disease; D000818:Animals; D001794:Blood Pressure; D002303:Cardiac Output, Low / Q000209:etiology; D002319:Cardiovascular System / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006321:Heart / Q000503:physiopathology; D006439:Hemodynamics; D006470:Hemorrhage / Q000000981:diagnostic imaging / Q000503:physiopathology*; D007113:Immunity, Innate; D017078:Laser-Doppler Flowmetry; D008297:Male; D008833:Microcirculation; D008853:Microscopy; D008991:Monitoring, Physiologic; D051381:Rats; D014463:Ultrasonography