title: A new place conditioning paradigm to study tolerance to opiates in mice.
abstract: Tolerance to the rewarding properties of morphine was investigated in mice using a new conditioned place preference (CPP) procedure. Four pairings of morphine with specific environmental cues induced a significant CPP for the drug-paired cues. Further opiate conditioning trials in the presence of the same environmental cues revealed no change in the drug-induced CPP on repeated test sessions. Subsequent exposure of the same animals to conditioning trials by pairing morphine with a set of novel environmental cues showed that the opiate was still able to produce a CPP in mice treated with a total of 16 morphine injections. The present CPP paradigm may prove useful to investigate tolerance to the rewarding properties of drugs of abuse.
authors: Dipartimento di Farmacologia, Padova, Italy.
authors: A
authors: A
authors: Contarino
authors: F
authors: F
authors: Drago
authors: A
authors: A
authors: Zanotti
authors: F
authors: F
authors: Natolino
authors: T
authors: T
authors: Berti
authors: P
authors: P
authors: Giusti
mesh_terms: D000818:Animals; D002755:Choice Behavior / Q000502:physiology*; D003213:Conditioning, Psychological / Q000502:physiology*; D003463:Cues; D004361:Drug Tolerance; D004777:Environment; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009020:Morphine / Q000494:pharmacology*; D012201:Reward
chemical_list: D009020:Morphine