title: A case of chronic neutrophilic leukemia with deletion (11)(q23).
abstract: We report a case of chronic neutrophilic leukemia (CNL) in a 68-year-old man. Karyotype showed a clonal abnormality, never described before in CNL: 46,XY,del(11)(q23). Southern blot analysis of the MLL gene did not reveal any rearrangement, and reverse transcriptase polymerase chain reaction (RT-PCR) analysis did not show any fusion of BCR-ABL. Treatment with hydroxyurea and cytosine arabisonide was ineffective.
authors: Laboratoire de Cytogénétique, Hôpital André Mignot, Le Chesnay, France.
authors: C
authors: C
authors: Terré
authors: I
authors: I
authors: Garcia
authors: J N
authors: JN
authors: Bastie
authors: D
authors: D
authors: Mayeur
authors: L
authors: L
authors: Decombe
authors: P
authors: P
authors: Gruyer
authors: R
authors: R
authors: Berger
authors: S
authors: S
authors: Castaigne
mesh_terms: D000368:Aged; D002872:Chromosome Deletion; D002880:Chromosomes, Human, Pair 11; D006801:Humans; D015467:Leukemia, Neutrophilic, Chronic / Q000235:genetics*; D008297:Male