Mycobacterium tuberculosis phagosome.
The arrest of Mycobacterium tuberculosis phagosome maturation in infected macrophages is a phenomenon of dual significance both for the pathogenesis of tuberculosis and as a model system to study interference of microbes with membrane trafficking and organelle biogenesis in host cells. Among other factors, compartment-specialized regulators of vesicular trafficking and other parts of membrane fusion machinery are likely to play a role in these processes. Here we summarize the emerging view of mycobacterial phagosome maturation arrest in the context of the dynamic processes of intracellular membrane trafficking.
Deretic
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Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor 48109-0620, USA. Deretic@umich.edu
Fratti
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RA
D002352:Carrier Proteins / Q000502:physiology; D027682:Cation Transport Proteins; D002478:Cells, Cultured; D016207:Cytokines / Q000502:physiology; D019204:GTP-Binding Proteins / Q000378:metabolism; D008565:Membrane Proteins / Q000502:physiology; D018613:Microscopy, Confocal; D008954:Models, Biological; D009163:Mycobacterium bovis / Q000378:metabolism; D009169:Mycobacterium tuberculosis / Q000502:physiology*; D010587:Phagocytosis / Q000502:physiology; D010588:Phagosomes / Q000378:metabolism*; D020691:rab GTP-Binding Proteins; D020696:rab5 GTP-Binding Proteins; D000090802:rab7 GTP-Binding Proteins; D000099173:Natural Resistance-associated Macrophage Protein 1
D002352:Carrier Proteins; D027682:Cation Transport Proteins; D016207:Cytokines; D019204:GTP-Binding Proteins; D008565:Membrane Proteins; D020691:rab GTP-Binding Proteins; D020696:rab5 GTP-Binding Proteins; D000090802:rab7 GTP-Binding Proteins; D000099173:Natural Resistance-associated Macrophage Protein 1