title: Genotoxic potential of cyclosporin A in patients with renal transplantation.
abstract: We analyzed the induction of sister chromatid exchange (SCE) by cyclosporin A (CsA) as a marker of genotoxic potential. In 30 patients undergoing renal transplantation, SCE induction was tested before the introduction of CsA and 3 months later. We found that SCE frequency increased significantly at the end of 3 months. To our knowledge, this is the first study demonstrating in vivo induction of SCE by CsA in humans. We conclude that CsA has a genotoxic potential on human lymphocytes.
authors: Istanbul Faculty of Medicine, Department of Internal Medicine, Branch of Medical Genetics, Turkey.
authors: S
authors: S
authors: Palanduz
authors: M S
authors: MS
authors: Sever
authors: S
authors: S
authors: Oztürk
authors: C
authors: C
authors: Taşçioğlu
authors: M A
authors: MA
authors: Karan
authors: G
authors: G
authors: Sönmez
authors: K
authors: K
authors: Cefle
authors: K
authors: K
authors: Güler
mesh_terms: D000293:Adolescent; D000328:Adult; D002478:Cells, Cultured; D016572:Cyclosporine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D012854:Sister Chromatid Exchange / Q000187:drug effects*
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine