title: Neuroprotective effects of acetylsalicylic acid in an animal model of focal brain ischemia.
abstract: Recent studies have shown neuroprotective effects of acetylsalicylic acid (ASA) in cell cultures and hippocampal slices. The present study demonstrates similar effects in a whole-animal modal of focal ischemic stroke. Focal cortical ischemia was produced in Wistar rats by ligation of the common carotid and middle cerebral arteries. Subjects were sacrificed 8 days after ligation, and infarct volume was assessed via automated densitometry. Significant reductions in infarct volume were seen with i.p. ASA doses of 15 mg/kg and above. Reductions occurred when ASA was injected 2 h or 30 min before ligation, but not when it was injected 8 or 24 h before, or 30 min after ligation.
authors: Department of Pharmacology, University of Toronto, ON, Canada.
authors: N
authors: N
authors: Khayyam
authors: P
authors: P
authors: Thavendiranathan
authors: F J
authors: FJ
authors: Carmichael
authors: B
authors: B
authors: Kus
authors: V
authors: V
authors: Jay
authors: W M
authors: WM
authors: Burnham
mesh_terms: D000818:Animals; D001241:Aspirin / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects / Q000473:pathology; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology*; D002544:Cerebral Infarction / Q000473:pathology; D008297:Male; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D018696:Neuroprotective Agents; D001241:Aspirin