Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo.
Cytotoxic T lymphocytes and natural killer cells are essential effectors of anti-tumor immune responses in vivo. Dendritic cells (DC) 'prime' tumor antigen-specific cytotoxic T lymphocytes; thus, we investigated whether DC might also trigger the innate, NK cell-mediated anti-tumor immunity. In mice with MHC class I-negative tumors, adoptively transferred- or Flt3 ligand-expanded DC promoted NK cell-dependent anti-tumor effects. In vitro studies demonstrated a cell-to-cell contact between DC and resting NK cells that resulted in a substantial increase in both NK cell cytolytic activity and IFN-gamma production. Thus, DC are involved in the interaction between innate and adaptive immune responses.
Fernandez
N C
NC
Département de Biologie Clinique, Institut Gustave Roussy, Villejuif, France.
Lozier
A
A
Flament
C
C
Ricciardi-Castagnoli
P
P
Bellet
D
D
Suter
M
M
Perricaudet
M
M
Tursz
T
T
Maraskovsky
E
E
Zitvogel
L
L
D019264:Adoptive Transfer; D000818:Animals; D002450:Cell Communication; D018920:Coculture Techniques; D003602:Cytotoxicity, Immunologic; D004268:DNA-Binding Proteins; D003713:Dendritic Cells / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology*; D008024:Ligands; D008213:Lymphocyte Activation; D008285:Major Histocompatibility Complex / Q000276:immunology; D008565:Membrane Proteins / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D008817:Mice, Mutant Strains; D009374:Neoplasms, Experimental / Q000145:classification / Q000276:immunology*
D004268:DNA-Binding Proteins; D008024:Ligands; D008565:Membrane Proteins; C499308:Rag2 protein, mouse; C064655:V(D)J recombination activating protein 2; C084881:flt3 ligand protein