title: Hydrostatic pulmonary edema: evaluation with thin-section CT in dogs.
abstract: OBJECTIVE
  To identify the hemodynamic determinants of ground-glass opacification on thin-section computed tomographic (CT) scans of hydrostatic pulmonary edema and to compare attenuation and subjective assessments of ground-glass opacification with extravascular lung water.
  
  
  METHODS
  Left atrial pressure, pulmonary arterial pressure, effective pulmonary capillary pressure, and extravascular lung water were measured in six dogs before and during progressive increase of effective pulmonary capillary pressure. A thin-section CT scan was obtained at each step. Lung attenuation and subjective assessments of ground-glass opacification were compared with hemodynamic variables and extravascular lung water.
  
  
  RESULTS
  Ground-glass opacification was identified when effective pulmonary capillary pressure equaled critical pulmonary capillary pressure. Extravascular lung water increased, and the distribution curve of lung attenuation coefficients shifted to higher attenuation from the second measurement at an effective pulmonary capillary pressure greater than the critical pulmonary capillary pressure. Attenuation was highly correlated (r = 0.98, P < .001) with extravascular lung water; ground-glass opacification was detected before a significant (P = .615, analysis of variance) increase in extravascular lung water.
  
  
  CONCLUSIONS
  Thin-section CT depicts ground-glass opacification when effective pulmonary capillary pressure equals critical pulmonary capillary pressure and before a detectable increase in extravascular lung water. Attenuation reflects extravascular lung water.
authors: Department of Radiology, Erasme University Hospital, Brussels, Belgium.
authors: P
authors: P
authors: Scillia
authors: M
authors: M
authors: Delcroix
authors: P
authors: P
authors: Lejeune
authors: C
authors: C
authors: Mélot
authors: J
authors: J
authors: Struyven
authors: R
authors: R
authors: Naeije
authors: P A
authors: PA
authors: Gevenois
mesh_terms: D000818:Animals; D004285:Dogs; D015633:Extravascular Lung Water / Q000000981:diagnostic imaging; D011652:Pulmonary Circulation / Q000502:physiology; D011654:Pulmonary Edema / Q000000981:diagnostic imaging* / Q000503:physiopathology; D014057:Tomography, X-Ray Computed / Q000379:methods*