[Methods of sleep induction for EEG recordings: comparison between three hypnotics and natural sleep].
We compared the effects of three oral hypnotics, monosodium trichloroethyl phosphate (MTP), chloral hydrate (CH), and pentobarbital calcium (PTB), to those of non-medication on wake-sleep states and sleep activation of epileptic seizure discharges. The subjects consisted of 410 epileptics and 171 non-epileptic outpatients (mean age: 12.5 years) of the Department of Pediatrics, Nagoya City University Hospital. Complete EEG records including awake and sleep states were obtained in 230/241 (95%) of patients with MTP, 20/22 (91%) of those with CH, 72/85 (85%) of those with PTB, and 225/233 (97%) of those without any hypnotics. There were no statistically significant differences in the effect of sleep induction among the four groups. Sleep activation effects were observed in 25% of patients with natural sleep and 35% of those with induced sleep. There was no statistical difference (p > 0.05). These results suggested MTP, CH, and PTB are useful hypnotics for sleep EEG recordings.
Takasaka
Y
Y
Department of Central Clinical Laboratories, Nagoya City University Hospital.
Ishikawa
T
T
Mizuno
K
K
Nakamura
C
C
Yamaguchi
A
A
Furuyama
M
M
Imanishi
R
R
Shibata
M
M
Fujimoto
S
S
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography / Q000187:drug effects; D004827:Epilepsy / Q000503:physiopathology; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D007223:Infant; D012890:Sleep / Q000502:physiology*; D012894:Sleep Stages / Q000502:physiology
D006993:Hypnotics and Sedatives