Antiinflammatory activity of some extracts from plants used in the traditional medicine of north-African countries (II).
Aqueous, ethanol and chloroform extracts from Corrigiliola telephiifolia, Echinops spinosus, Kundmannia sicula, Tamarindus indica and Zygophyllum gaetulum were evaluated for antiinflammatory properties in mice (ear oedema induced by arachidonic acid) and rats (subplantar oedema induced by carrageenan) after topical or i.p. administration, respectively. Our results showed that all the plants exhibit antiinflammatory activity, since at least one extract from each plant was active in one of the experimental models. Whereas all the extracts of Corrigiliola telephiifolia and Echinops spinosus were highly active on all the experimental models assayed (values of inflammation inhibition well above 50%), poorer activity profiles were recorded in Kundmannia sicula, Tamarindus indica and Zygophyllum gaetulum. These results support the traditional uses for these plants but indicate that the active principles in the chloroform extracts are probably more active and/or are contained in larger concentrations than the principles in the polar extracts used in the traditional medicine of North-African countries.
Rimbau
V
V
Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Universitat de Barcelona, Spain.
Cerdan
C
C
Vila
R
R
Iglesias
J
J
D000279:Administration, Cutaneous; D000352:Africa, Northern; D000704:Analysis of Variance; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D016718:Arachidonic Acid; D002351:Carrageenan; D004195:Disease Models, Animal; D004431:Ear, External; D004487:Edema / Q000139:chemically induced / Q000628:therapy; D005260:Female; D005528:Foot; D008297:Male; D016488:Medicine, African Traditional; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects*
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D016718:Arachidonic Acid; D002351:Carrageenan