[Synthesis, antimicrobial effects and adverse effects of new structures of urea, hydrogen peroxide and tensides].
A substantial extension of the applicability of hydrogen peroxide will be reached by using occlusion compounds of anionic, amphoteric (dipolar ionic), cationic, nonionic, or polyfunctional tensides with hydrogen peroxide in urea. Occlusion compounds with 3 as well as with 4 components containing natural equivalent and antimicrobial effective tensides were synthesized and tested. By synthesis in an anhydrous system the content of active substances as well as the mixture ratio of the components may be adapted to the conditions necessary according to the appropriate purpose. Occlusion compounds are characterized by a broad and well-balanced spectrum of antimicrobial effectivity. Concentrations in the range of 0.1 to 0.4% are practicable to preserve pharmaceutical preparations or technical products, respectively. Several compounds show a sporicidal activity in concentrations between 0.3 and 0.6% and, with an appropriate action time (> 24 h) also a moderate effectivity against polioviruses. In the conventional cell culture, in the perfusion cell culture, and in the phytotoxicity test using cress seed, respectively, low biological activity of the occlusion compounds was found.
Jülich
W D
WD
Landeshygieneinstitut Mecklenburg-Vorpommern, Greifswald, Germany.
Ohme
R
R
Alhitari
N
N
Adrian
V
V
von Woedtke
T
T
Kramer
A
A
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D006540:Herbicides / Q000138:chemical synthesis / Q000494:pharmacology; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D017955:Poliovirus / Q000187:drug effects; D013171:Spores, Bacterial / Q000187:drug effects; D013501:Surface-Active Agents / Q000494:pharmacology*; D014508:Urea / Q000031:analogs & derivatives* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000998:Antiviral Agents; D006540:Herbicides; D013501:Surface-Active Agents; D014508:Urea; D006861:Hydrogen Peroxide