Relation between aerobic fitness level and stress induced alterations in neuroendocrine and immune function.
Alterations in neuroendocrine and immune function were examined in sedentary (n=15) (VO2peak; 31.4+/-0.7 ml x kg(-1) x min(-1); 24.4+/-1.2yr), moderately active (n=15) (VO2peak; 45.4+/-1.1 ml x kg(-1) x min(-1); 24.2+/-1.1 yr) and aerobically trained (n=15) (VO2peak; 58.8+/-0.9 ml x kg(-1) x min(-1); 24.3+/-1.0 yr) men following exposure to an acute mild psychological stressor. Subjects had 2 min to prepare, and 3 min to deliver a speech in front of 3 observers. Blood samples were drawn from an indwelling catheter before, during and 30 min following the speech task (ST). Self-reported measures of anxiety were obtained prior to and immediately following the stressor. The ST resulted in significant alterations in the number and function of immune cells, and in self-reported anxiety scores. Plasma levels of norepinephrine increased during the speech task. The neuroendocrine and immune response to the chosen stressor were independent of subject aerobic fitness level.
Moyna
N M
NM
Department of Pathology, University of Pittsburgh, USA. NMoyna@Harthosp.org
Bodnar
J D
JD
Goldberg
H R
HR
Shurin
M S
MS
Robertson
R J
RJ
Rabin
B S
BS
D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007111:Immunity, Cellular; D016130:Immunophenotyping; D007694:Killer Cells, Natural; D007958:Leukocyte Count; D008297:Male; D009638:Norepinephrine / Q000097:blood*; D010809:Physical Fitness; D013312:Stress, Physiological / Q000097:blood*
D006854:Hydrocortisone; D009638:Norepinephrine