[Reactive restructuring of smooth muscle tissue in response to large fraction irradiation of rectal cancer].
Rectum smooth muscles of 19 patients were studied after presurgical irradiation. A comparative analysis of isolated smooth myocytes from various areas of resected intestine was performed morphometrically and cytophotometrically. Suppression of proliferative activity and protein synthesis, elimination of large myocytes were observed in the foci of intensive irradiation. Smooth myocytes in the margin zones retain structure, proliferative potential and cytoplasmatic protein content this allowing to consider smooth muscles of these zones to be able for complete reparative regeneration. Electron microscopy confirmed the structural alteration observed.
Zashikhin
A L
AL
Arkhangelsk State Medical Academy, Sweden.
Selin
Ia
Ia
Agafonov
Iu V
IuV
Pakhtusova
N V
NV
Zolotkov
A T
AT
D002455:Cell Division / Q000502:physiology; D019583:Dose Fractionation, Radiation; D006801:Humans; D008854:Microscopy, Electron; D009124:Muscle Proteins / Q000096:biosynthesis; D009130:Muscle, Smooth / Q000473:pathology / Q000528:radiation effects*; D011300:Preoperative Care / Q000379:methods*; D012004:Rectal Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D012038:Regeneration
D009124:Muscle Proteins