Tissue transglutaminase: apoptosis versus autoimmunity.
Autoimmune diseases are characterized by multiple autoantibodies and/or autoreactive T cells that recognize a large number of antigens. Many of these antigens undergo extensive post-translational modifications during apoptosis and act as substrates for the proapoptotic cystein proteases. Here, Mauro Piacentini and Vittorio Colizzi discuss the effects on autoimmunity produced by post-translational modifications of proteins catalysed by the proapoptotic enzyme tissue transglutaminase.
Piacentini
M
M
Dept of Biology, University of Rome Tor Vergata, Italy. mauro.piacentini@UniRoma2.it
Colizzi
V
V
D000818:Animals; D017209:Apoptosis / Q000276:immunology / Q000502:physiology*; D001323:Autoantibodies / Q000032:analysis; D015551:Autoimmunity; D002477:Cells / Q000201:enzymology / Q000378:metabolism; D006801:Humans; D011499:Protein Processing, Post-Translational; D011503:Transglutaminases / Q000276:immunology*
D001323:Autoantibodies; D011503:Transglutaminases