title: Infantile botulism: pitfalls in electrodiagnosis.
abstract: Botulism in infants, unless recognized early, is associated with high mortality and morbidity. The diagnosis is suspected when infants present with sudden onset of weakness, respiratory failure, and constipation and is confirmed by demonstration of botulinum toxin in stool several weeks later. Electrodiagnosis allows quick and reliable confirmation of botulism. Low-amplitude compound muscle action potentials, tetanic or post-tetanic facilitation, and the absence of post-tetanic exhaustion support the diagnosis. Two infants with confirmed botulism did not exhibit the characteristic electrodiagnostic features, demonstrating the pitfalls in electrodiagnosis of infantile botulism.
authors: Department of Neurology, University of Wisconsin, Madison 53792-5132, USA. sheth@neurology.wisc.edu
authors: R D
authors: RD
authors: Sheth
authors: B P
authors: BP
authors: Lotz
authors: K E
authors: KE
authors: Hecox
authors: A J
authors: AJ
authors: Waclawik
mesh_terms: D001706:Biopsy; D001906:Botulism / Q000175:diagnosis*; D003014:Clostridium botulinum / Q000302:isolation & purification; D003951:Diagnostic Errors; D004568:Electrodiagnosis / Q000379:methods*; D005243:Feces / Q000382:microbiology; D005260:Female; D006801:Humans; D007223:Infant; D009132:Muscles / Q000473:pathology