[Concept of control of galenic properties in oral administration of drugs].
The pharmaceutical and biopharmaceutical development of drug preparations comprehends the transformation of a drug in an applicable drug preparation with optimal efficacy, safety and acceptance. Thus, a drug delivery system has to be developed that controls the onset, the duration and the intensity of the expected effect. Depending on the specific drug properties and to the special objectives different controlling principles have to be selected. These are for example delayed release (salivaresistance, gastroresistance), slow release, release in distinct regions of the gastrointestinal tract and accelerated release.
Lippold
B C
BC
Institut für Pharmazeutische Technologie, Heinrich-Heine-Universität Düsseldorf. lippold@uni-duesseldorf.de
D000284:Administration, Oral; D001711:Biotransformation; D004339:Drug Compounding; D016503:Drug Delivery Systems; D006801:Humans; D010599:Pharmacokinetics