Chemical ligation to obtain proteins comprising helices with individual amino acid sequences.
Development of the strategies for assembling multiple kinds of peptide segments would give new possibilities for the de novo design of functional proteins. We will introduce our approach for the selective assembly of helical peptide segments on a peptide template to give four-helix-bundle proteins comprising individual helices.
Futaki
S
S
Institute for Medicinal Resources, The University of Tokushima, Japan. futaki@scl.kyoto-u.ac.jp
Aoki
M
M
Ishikawa
T
T
Kondo
F
F
Asahara
T
T
Niwa
M
M
Nakaya
Y
Y
Yagami
T
T
Kitagawa
K
K
D000595:Amino Acid Sequence; D000818:Animals; D002942:Circular Dichroism; D004593:Electrophorus / Q000378:metabolism; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry*; D017433:Protein Structure, Secondary; D011506:Proteins / Q000138:chemical synthesis* / Q000737:chemistry; D015222:Sodium Channels / Q000737:chemistry
D010455:Peptides; D011506:Proteins; D015222:Sodium Channels