[The contribution of the mu- and delta-opiate receptors to the realization of the vagotropic action of met-enkephalin].
In cat experiments the effect of methenkephalin on the heart rate, on the chronotropic effect of the vagus and its components--tonic and synchronizing was compared with the influence of the selective agonists and antagonists mu- and delta-opiate receptors. The influence of methenkephalin on the initial heart rate and the synchronizing component of the vagal chronotropic effect was found to be realized through excitation of the delta-opiate receptors. The modulating effect of methenkephalin on the expression of the inhibiting tonic action of the vagus was mediated both by the mu- and delta-opiate receptors.
Osadchiĭ
O E
OE
Department of Normal Physiology, Kuban Medical Academy, Krasnodar, Russia.
Pokrovskiĭ
V M
VM
D000818:Animals; D002415:Cats; D004562:Electrocardiography / Q000187:drug effects / Q000379:methods; D004744:Enkephalin, Methionine / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D017465:Receptors, Opioid, delta / Q000819:agonists / Q000037:antagonists & inhibitors / Q000187:drug effects / Q000502:physiology*; D017450:Receptors, Opioid, mu / Q000819:agonists / Q000037:antagonists & inhibitors / Q000187:drug effects / Q000502:physiology*; D013268:Stimulation, Chemical; D013997:Time Factors; D014630:Vagus Nerve / Q000187:drug effects* / Q000502:physiology
D017465:Receptors, Opioid, delta; D017450:Receptors, Opioid, mu; D004744:Enkephalin, Methionine