Model for the regulation of energy balance and adiposity by the central nervous system.
In 1995, we described a new model for adiposity regulation. Since then, data regarding the biology of body weight regulation has accumulated at a remarkable rate and has both modified and strengthened our understanding of this homeostatic system. In this review we integrate new information into a revised model for further understanding this important regulatory process. Our model of energy homeostasis proposes that long-term adiposity-related signals such as insulin and leptin influence the neuronal activity of central effector pathways that serve as controllers of energy balance.
Schwartz
M W
MW
Department of Medicine, University of Washington, Harborview-Medical Center and the VA Puget Sound Health Care System, Seattle 98108, USA. mschwart@u.washington.edu
Baskin
D G
DG
Kaiyala
K J
KJ
Woods
S C
SC
D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D019167:Appetite Stimulants; D001835:Body Weight; D004734:Energy Metabolism; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007031:Hypothalamus / Q000502:physiology; D008954:Models, Biological; D009478:Neuropeptide Y / Q000502:physiology
D019167:Appetite Stimulants; D009478:Neuropeptide Y