title: The pattern of changes in ovarian stromal and uterine artery blood flow velocities during in vitro fertilization treatment and its relationship with outcome of the cycle.
abstract: OBJECTIVE
  To assess the effect of short-term (2-3 weeks) pituitary suppression and controlled ovarian stimulation on ovarian and uterine artery Doppler measurements during the in vitro fertilization (IVF) treatment cycle and to compare the pattern of these changes between conception and non-conception cycles as well as between patients with normal and those with polycystic ovaries.
  
  
  METHODS
  Prospective observational study of women undergoing IVF treatment.
  
  
  METHODS
  Women using the long-treatment buserelin protocol who did not have uterine fibroids, ovarian cysts or endometrioma.
  
  
  METHODS
  Serial transvaginal color and pulsed Doppler measurements of ovarian stromal and uterine artery blood flow velocity were carried out in the early follicular phase of the menstrual cycle, on the day of pituitary suppression and on the day of administration of human chorionic gonadotropin (hCG). The main outcome measures were the ovarian stromal and uterine artery blood flow peak systolic velocity (PSV) and pulsatility index (PI).
  
  
  RESULTS
  A total of 105 patients were recruited but six patients were excluded from the analysis because they had only one stage of the measurements performed. There was a significant decline in mean ovarian stromal artery PSV after 2-3 weeks of gonadotropin releasing hormone (GnRH) agonist therapy but no effect on ovarian stromal artery PI. The mean uterine artery PSV or PI did not change significantly after 2-3 weeks of GnRH agonist therapy. There was a significantly higher mean ovarian stromal artery PSV in conception cycles compared to non-conception cycles in the early follicular phase and on the day of pituitary suppression, but not on the day of hCG administration. There were no differences between conception and non-conception cycles in the mean uterine artery PSV or PI. Women with polycystic ovaries had a higher mean ovarian artery PSV on all the three occasions of measurement.
  
  
  CONCLUSIONS
  These data suggest that assessment of ovarian blood flow before commencement of gonadotropin stimulation may play a role in assessing cycles likely to result in pregnancy.
authors: London Women's Clinic, UK.
authors: L
authors: L
authors: Engmann
authors: P
authors: P
authors: Sladkevicius
authors: R
authors: R
authors: Agrawal
authors: J
authors: J
authors: Bekir
authors: S
authors: S
authors: Campbell
authors: S L
authors: SL
authors: Tan
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity; D002064:Buserelin / Q000627:therapeutic use; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D019160:Endosonography; D005260:Female; D005307:Fertilization in Vitro; D005498:Follicular Phase; D005500:Follow-Up Studies; D006801:Humans; D007083:Iliac Artery / Q000000981:diagnostic imaging*; D007247:Infertility, Female / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D010053:Ovary / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000187:drug effects; D011085:Polycystic Ovary Syndrome / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000503:physiopathology; D011247:Pregnancy; D011446:Prospective Studies; D011673:Pulsatile Flow; D016896:Treatment Outcome; D018615:Ultrasonography, Doppler, Color; D014599:Uterus / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000187:drug effects; D014621:Vagina / Q000000981:diagnostic imaging
chemical_list: D006063:Chorionic Gonadotropin; D002064:Buserelin