[The effect of reversible ischemia of the rat liver on antipyrine metabolism and the isoenzyme activity of cytochrome P-450].
The character of changes in the metabolism of antipyrine, etoxy-, methoxy- and pentoxyresurphin after total reversible ischemia of the liver was studied in rats. In animals highly resistant to hypoxia the metabolism of xenobiotics specific to cytochromes P-450 IA1, IA2, and IIB1 was inhibited; in subjects with low resistance to hypoxia only P-450 and IA1 activity was suppressed while the activity of P-450 IIB1 and IA2 increased 2-3-fold.
Grek
O R
OR
Department of Pharmacology, Novosibirsk Medical Institute, Russia.
Eshkina
T A
TA
Sharapov
V I
VI
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics* / Q000652:urine; D000983:Antipyrine / Q000493:pharmacokinetics* / Q000652:urine; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D000860:Hypoxia / Q000201:enzymology; D007511:Ischemia / Q000201:enzymology*; D007527:Isoenzymes / Q000378:metabolism; D008099:Liver / Q000098:blood supply* / Q000201:enzymology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007527:Isoenzymes; D003577:Cytochrome P-450 Enzyme System; D000983:Antipyrine