Sex- and age-related differences in ceramide dihexosides of primary human brain tumors.
Neutral glycolipids (NGL) are promising diagnostic markers of human gliomas, but differences in NGL with age and sex have not been examined. Previous work demonstrated that ceramide dihexosides (CDH) levels in mouse kidney are age- and sex-dependent, probably due to levels of sex hormones. We quantitated CDH in 181 human gliomas and found significant differences with sex and age, particularly menopause and male puberty. This emphasizes the importance of assessing results of studies on glycolipids in disease states with respect to age and sex in order to avoid erroneous conclusions concerning the relationship of glycolipid composition with diagnosis and pathogenesis.
Yates
A J
AJ
Department of Pathology, The Ohio State University, Columbus 43210, USA. yates.1@osu.edu
Franklin
T K
TK
Scheithauer
B W
BW
Burger
P C
PC
Pearl
D K
DK
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001254:Astrocytoma / Q000737:chemistry* / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000032:analysis*; D001932:Brain Neoplasms / Q000737:chemistry* / Q000378:metabolism; D002855:Chromatography, Thin Layer / Q000379:methods; D005260:Female; D006028:Glycosphingolipids / Q000032:analysis* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009837:Oligodendroglioma / Q000737:chemistry* / Q000378:metabolism; D012727:Sex Characteristics
D014408:Biomarkers, Tumor; D006028:Glycosphingolipids; C013869:ceramide dihexoside