Neuropeptide Y: a key molecule in anorexia and cachexia in wasting disorders?
Anorexia and body weight loss are characteristic of many diseases, including cancer and AIDS. Recent studies indicate that inflammatory cytokines, such as interleukin 1, the interleukin 6 subfamily and tumor necrosis factor, induce anorexia and cachexia by inhibiting the normal adaptive feeding response to energy deficits. Here, I discuss the evidence for and against a central role for neuropeptide Y and leptin in anorexia and cachexia.
Inui
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Second Dept of Internal Medicine, Kobe University School of Medicine, Japan. inui@med.kobe-u.ac.jp
D000818:Animals; D000855:Anorexia / Q000209:etiology*; D001066:Appetite; D002100:Cachexia / Q000209:etiology*; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism; D009478:Neuropeptide Y / Q000502:physiology*; D013577:Syndrome; D019282:Wasting Syndrome / Q000209:etiology*
D016207:Cytokines; D009478:Neuropeptide Y