Membrane transport: Take your fusion partners.
Recent studies of how vesicles are targeted to fuse with specific membranes inside cells highlight a role for extended coiled-coil proteins in tethering partner membranes prior to formation of the 'SNARE complex' that mediates the fusion reaction. The tethering protein is recruited to membranes by a Rab family GTPase
Clague
M J
MJ
Physiological Laboratory, University of Liverpool, Crown Street, Liverpool, L69 3BX, UK. clague@liv.ac.uk
D000818:Animals; D001692:Biological Transport; D011992:Endosomes / Q000502:physiology; D006160:Guanosine Triphosphate / Q000378:metabolism; D007425:Intracellular Membranes / Q000502:physiology*; D008565:Membrane Proteins / Q000378:metabolism; D015388:Organelles / Q000502:physiology; D050600:SNARE Proteins; D012441:Saccharomyces cerevisiae; D033921:Vesicular Transport Proteins
D008565:Membrane Proteins; D050600:SNARE Proteins; D033921:Vesicular Transport Proteins; D006160:Guanosine Triphosphate