Ethosuximide inducted changes in the gastro-intestinal tract.
Ethosuximide is an alternative medicament that is used for coupling of petit mal, especially in childhood. Some clinical observations show that it has secondary effects on the gastro intestinal tract (GIT). The present research tries to define the characteristics of Ethosuximide--the inducted secondary effects on the GIT, and to explain some of the possible mechanisms that cause them. The changes that occur in the GIT of patients cured with Ethosuximide are registered roentgenologically. The main change is the atony of the stomach and intestines and the reduced peristaltic activity. The influence of Ethosuximide is examined on smooth muscular samples of human stomach, taken in vitro using stomach resection. The medicament authoritatively reduce the spontaneous bioelectrical activity of the smooth muscular tissue, influences mainly it's components that have Ca+ nature. Together with that is indicated relaxation of the smooth muscular samples. In that research is expressed the thesis that this Ethosuximide reduction of the Ca(+)-influx in the smooth muscular cells and the related relaxation probably are one of the main reasons of the secondary effects on the GIT.
Zagorchev
P
P
Department of Radiology, Medical Faculty, Higher Medical Institute, Plovdiv, Bulgaria.
Sirakov
V
V
Uchikov
A
A
Sirakov
N
N
D000293:Adolescent; D000927:Anticonvulsants / Q000009:adverse effects*; D004064:Digestive System / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000503:physiopathology; D004832:Epilepsy, Absence / Q000188:drug therapy / Q000503:physiopathology; D005013:Ethosuximide / Q000009:adverse effects*; D006801:Humans; D066298:In Vitro Techniques; D009130:Muscle, Smooth / Q000187:drug effects / Q000503:physiopathology; D011859:Radiography
D000927:Anticonvulsants; D005013:Ethosuximide