title: Analysis of scintigraphical lung images before and after treatment of horses suffering from chronic pulmonary disease.
abstract: Scintigraphical analysis of the ratio of inhalation (I) to perfusion (Q) was designed to determine whether chronic pulmonary disease in horses induced mismatches in I/Q and to assess whether medical treatment would restore an I/Q distribution pattern identical to that of control horses. In addition, the results of the I/Q analysis were correlated with the alveolar-arterial PO2 difference (AaDO2). The I/Q matching found in a group of control horses was compared with the I/Q analysis of a group of diseased horses before and after their clinical signs had been treated. The analysis indicated that there was mismatching between I and Q before they were treated. The treatment improved the diseased horses, pulmonary function but there was still heterogeneity in the I/Q distribution after they had been treated. The I/Q analysis parameters were well correlated with the ratio of ventilation (VA) and pulmonary blood flow (Q), evaluated by the determination of AaDO2.
authors: Department of Physiology, Faculty of Veterinary Medicine, University of Liège, Belgium.
authors: D
authors: D
authors: Votion
authors: Y
authors: Y
authors: Ghafir
authors: S
authors: S
authors: Vandenput
authors: D H
authors: DH
authors: Duvivier
authors: T
authors: T
authors: Art
authors: P
authors: P
authors: Lekeux
mesh_terms: D000336:Aerosols; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D001784:Blood Gas Analysis; D002511:Cephalosporins / Q000008:administration & dosage; D006734:Horse Diseases / Q000000981:diagnostic imaging* / Q000188:drug therapy; D006736:Horses; D008173:Lung Diseases, Obstructive / Q000145:classification / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000662:veterinary*; D011239:Prednisolone / Q000008:administration & dosage; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012016:Reference Values; D012720:Severity of Illness Index; D013668:Technetium Tc 99m Aggregated Albumin; D014692:Ventilation-Perfusion Ratio
chemical_list: D000336:Aerosols; D000893:Anti-Inflammatory Agents; D002511:Cephalosporins; D019275:Radiopharmaceuticals; D013668:Technetium Tc 99m Aggregated Albumin; C053503:ceftiofur; D011239:Prednisolone