title: Synthesis of bisquinolines and their in vitro ability to produce methemoglobin in canine hemolysate.
abstract: Synthesis of a number of derivatives of bisquinolines (3-9) have been reported here. Effect of these compounds on in vitro methemoglobin formation and methemoglobin reductase activity has resulted in the identification of two potential compounds (5 & 7), showing negligible methemoglobin toxicity.
authors: Division of Biochemistry, Central Drug Research Institute, Lucknow, India.
authors: S
authors: S
authors: Srivastava
authors: S
authors: S
authors: Tewari
authors: P M
authors: PM
authors: Chauhan
authors: S K
authors: SK
authors: Puri
authors: A P
authors: AP
authors: Bhaduri
authors: V C
authors: VC
authors: Pandey
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology; D002738:Chloroquine / Q000494:pharmacology; D042966:Cytochrome-B(5) Reductase / Q000037:antagonists & inhibitors*; D004285:Dogs; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008706:Methemoglobin / Q000378:metabolism* / Q000494:pharmacology; D011319:Primaquine / Q000494:pharmacology; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000962:Antimalarials; D004791:Enzyme Inhibitors; D011804:Quinolines; D002738:Chloroquine; D008706:Methemoglobin; D042966:Cytochrome-B(5) Reductase; D011319:Primaquine