title: MUC1 expression in intramucosal colorectal neoplasms. Possible involvement in histogenesis and progression.
abstract: OBJECTIVE
  The mucin core peptide MUC1 often is detectable in colorectal carcinoma (CRC) tissue and cell lines. However, whether MUC1 in CRC correlates with tumor histogenesis and progression is unclear. We studied the relationship between MUC1 expression in intramucosal CRC and clinicopathologic features, expression of Ki-67, and p53 protein, and apoptosis.
  
  
  METHODS
  The intramucosal CRC we studied included 140 endoscopically or surgically resected lesions, including 106 low-grade carcinomas and 34 high-grade carcinomas. De novo carcinoma, defined as carcinoma with no adenomatous component, represented 9 of 140 tumors. Three macroscopic types were identified: 57 lesions were polypoid, 55 were superficial and flat, and 28 were granular-type laterally spreading tumors (G-LST). MUC1, Ki-67, and p53 expression were examined immunohistochemically. Apoptotic cells were identified by in situ DNA nick end labeling.
  
  
  RESULTS
  MUC1 expression in high-grade carcinomas was significantly more frequent (p < 0.01) than in low-grade carcinomas; expression in adenomas was almost nil. MUC1 expression in polypoid carcinomas was significantly more frequent (p < 0.05) than in superficial carcinomas or G-LST. MUC1 expression in carcinomas with p53 expression was significantly more frequent (p < 0.01) than in carcinomas not expressing p53. No significant correlation was found between expression of MUC1 and Ki-67 labeling index. MUC1 was expressed more frequently in carcinomas with relatively high apoptotic index (p < 0.01). MUC1 expression did not differ between de novo carcinomas and those developing from adenomas.
  
  
  CONCLUSIONS
  The results suggest that MUC1 is likely to be expressed in the course of colorectal carcinoma development when p53 protein is overexpressed and apoptosis is prominent.
authors: First Department of Internal Medicine, Hiroshima University School of Medicine, Hiroshima, Japan. tatsuro@ue.ipe.hiroshima-u.ac.jp
authors: T
authors: T
authors: Tanimoto
authors: S
authors: S
authors: Tanaka
authors: K
authors: K
authors: Haruma
authors: M
authors: M
authors: Yoshihara
authors: K
authors: K
authors: Sumii
authors: G
authors: G
authors: Kajiyama
authors: F
authors: F
authors: Shimamoto
authors: N
authors: N
authors: Kohno
mesh_terms: D017209:Apoptosis; D015179:Colorectal Neoplasms / Q000737:chemistry* / Q000473:pathology*; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007413:Intestinal Mucosa / Q000737:chemistry / Q000473:pathology; D019394:Ki-67 Antigen / Q000032:analysis / Q000276:immunology; D018396:Mucin-1 / Q000032:analysis* / Q000276:immunology; D016159:Tumor Suppressor Protein p53 / Q000032:analysis / Q000276:immunology; D015854:Up-Regulation
chemical_list: D019394:Ki-67 Antigen; D018396:Mucin-1; D016159:Tumor Suppressor Protein p53