[Atherosclerosis--a chronic infectious disease caused by Chlamydia pneumoniae].
Recent investigations allow a controversial but convincing interpretation of the pathogenesis of atherosclerosis (arteriosclerosis). Atherosclerosis can be apparently the result of ultrachronic persistent infection by Chlamydia pneumoniae and not the result of heterogenous risk factors. The main arguments for the chlamydial genesis are: Correlation of coronary heart disease and other atherosclerotic diseases and antibodies against Chlamydia pneumoniae. Chlamydia pneumoniae could be detected with different techniques (PCR, ICC, immunohistology, electromicroscopy, culture) in a high percentage in atheromas from different sites. Three successful international studies with macrolides in coronary heart disease. Target cells of atherosclerosis (endothelia, macrophages, muscle cells) can be infected by Chlamydia pneumoniae in vitro. Provocation of an arteriitis in animal experiments. The reduction of incidence of atherosclerotic diseases since the 1960s, probably due to advanced antibiotic therapy. Elevated acute-phase proteins and other inflammatory signs (CRP, WBC count, fibrinogen) briefly before occurrence of myocardial infarction. There are good arguments for intervention studies in coronary heart disease and other manifestations of atherosclerosis. The relevant antibiotics are licensed for chlamydial infections, cheap and safe. Meticulous records and long-term observation of patients need to be developed, sometimes contrary to interests of the pharmaceutical industry.
Stille
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Zentrum der Inneren Medizin/Infektiologie der Johann Wolfgang Goethe-Universität, Frankfurt/M.
Stephen
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D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology / Q000382:microbiology*; D002690:Chlamydia Infections / Q000150:complications / Q000382:microbiology*; D016993:Chlamydophila pneumoniae / Q000472:pathogenicity*; D002908:Chronic Disease; D006801:Humans