[The effect of platinum-containing cytostatic preparations on the immune and hematopoietic systems].
Experiments on male CBA/CA Lac mice [correction of rats] showed that a maximum tolerance dose of platidiam suppresses the primary humoral immune response stimulated by the thymus-dependent antigen in the late period (30 days), and has practically no immunosuppressive effect at the early stages (4 days) after injection of the cytostatic drug; it raises the phagocytizing activity of the peritoneal macrophages and increases the number of monocytes in the peripheral blood.
Masnaia
N V
NV
Institute of Pharmacology, Tomsk Research Center, Siberian Branch, Russian Academy of Medical Sciences, Russia.
Ratner
G M
GM
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002945:Cisplatin / Q000494:pharmacology*; D006413:Hematopoietic System / Q000187:drug effects* / Q000502:physiology; D007107:Immune System / Q000187:drug effects* / Q000276:immunology; D007111:Immunity, Cellular / Q000187:drug effects; D007114:Immunization / Q000379:methods; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010587:Phagocytosis / Q000187:drug effects; D013997:Time Factors
D000970:Antineoplastic Agents; D002945:Cisplatin