title: Single-shot echo-planar imaging of multiple sclerosis: effects of varying echo time.
abstract: Our aim was to determine the relative merits of short and long echo times (TE) with single-shot echo-planar imaging for imaging cerebral lesions such as multiple sclerosis. We examined seven patients with clinically definite multiple sclerosis were imaged at 1.5 T. Patients were scanned with spinecho, single-shot echo-planar imaging, using TEs of 45, 75, 105, and 135 ms. Region of interest (ROI) measurements were performed on 36 lesions at or above the level of the corona radiata. The mean image contrast (IC) was highest (231.1) for a TE of 45 ms, followed by 75 ms (218.9), 105 ms (217.9), and 135 ms (191.6). When mean contrast-to-noise ratios (C/N) were compared, the value was again highest (29.7) for TE 45 ms, followed by 75 ms (28.9), 105 ms (28.5), and 135 ms (26.3). In a lesion-by-lesion comparison, TE 45 ms had the highest IC and C/N in the largest number of cases (50 % and 47.2 %, respectively). IC and C/N for TE 45 ms were superior to those of 75 ms in 64% and 58%, respectively. These results support the use of relatively short TEs for single-shot echo-planar imaging in the setting of cerebral lesions such as multiple sclerosis.
authors: Department of Radiology, New Jersey Medical School/University of Medicine and Dentistry of New Jersey, Newark 07103, USA. LWolansky@aol.com
authors: L J
authors: LJ
authors: Wolansky
authors: S
authors: S
authors: Chong
authors: W C
authors: WC
authors: Liu
authors: E
authors: E
authors: Kang
authors: S W
authors: SW
authors: Simpson
authors: S
authors: S
authors: Karimi
authors: H
authors: H
authors: Akbari
mesh_terms: D002540:Cerebral Cortex / Q000473:pathology; D017352:Echo-Planar Imaging / Q000379:methods / Q000592:standards; D006801:Humans; D007089:Image Enhancement; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000473:pathology; D012016:Reference Values