[mu-Opiate receptor activation and increase in heart resistance to ischemic and reperfusion injury].
Stimulation of mu-opioid receptors was found to contribute to prevention of myocardial contractile dysfunction and ventricular arrhythmias in ischemia and reperfusion of the rat isolated heart. Endogenous agonists of the mu-opioid receptors were not involved in tonic regulation of the heart resistance against reperfusion disturbances of the rhythm and contractility. On the other hand, mu-opioid receptors are important for development of postischemic contracture.
Lishmanov
Iu B
IuB
Research Institute of Cardiology, Russian Acad. Med. Sci., Siberian Branch, Tomsk, Russia.
Maslov
L N
LN
Naumova
A V
AV
Bogomaz
S A
SA
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004562:Electrocardiography; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D004745:Enkephalins / Q000494:pharmacology; D066298:In Vitro Techniques; D008024:Ligands; D017202:Myocardial Ischemia / Q000503:physiopathology*; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology*; D009292:Narcotic Antagonists / Q000494:pharmacology; D009842:Oligopeptides / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017450:Receptors, Opioid, mu / Q000819:agonists* / Q000037:antagonists & inhibitors
D004745:Enkephalins; D008024:Ligands; D009292:Narcotic Antagonists; D009842:Oligopeptides; D010455:Peptides; D017450:Receptors, Opioid, mu; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; C063076:tyrosyl-arginyl-phenylalanyl-lysinamide; C009862:connective tissue-activating peptide