title: Effects of X-ray irradiation on genomic DNA methylation levels in mouse tissues.
abstract: Effects of ionizing radiation on the level of genomic DNA methylation in liver, brain and spleen of mouse as well as in two kinds of cultured cells were examined by high-performance liquid chromatography. Ten Gy of whole body X-radiation reduced the 5-methyldeoxycytidine contents by about 40% within 8 hours after irradiation in liver. Similar effects were observed at 4 or 7 Gy of X-ray irradiation. However, no such change was detected in brain, spleen and cultured cells. The data indicate that radiation-induced alteration in genomic DNA methylation is not ubiquitous among different tissues and cells.
authors: Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, Japan.
authors: R
authors: R
authors: Tawa
authors: Y
authors: Y
authors: Kimura
authors: J
authors: J
authors: Komura
authors: Y
authors: Y
authors: Miyamura
authors: A
authors: A
authors: Kurishita
authors: M S
authors: MS
authors: Sasaki
authors: H
authors: H
authors: Sakurai
authors: T
authors: T
authors: Ono
mesh_terms: D000818:Animals; D001921:Brain / Q000528:radiation effects; D001923:Brain Chemistry; D002478:Cells, Cultured; D002851:Chromatography, High Pressure Liquid; D019175:DNA Methylation / Q000528:radiation effects*; D016678:Genome; D008099:Liver / Q000737:chemistry / Q000528:radiation effects; D051379:Mice; D013154:Spleen / Q000737:chemistry / Q000528:radiation effects