Methoxybutropate microencapsulation by gelatin-acacia complex coacervation.
Microcapsules of methoxybutropate solid particles or of an oily saturated solution of the same drug were prepared by complex coacervation between gelatin and acacia and dried with three different methods: isopropanol addition, spray-drying, and freeze-drying. Successively, microparticles were analyzed by infrared thermobalance, ultraviolet (UV) spectroscopy, optical and scanning electron microscopy, and sieves to find out parameters such as yield, moisture content, encapsulation percentage, morphology of solid particles, and particle size. Results highlighted that the most appropriate drying method for industrial purposes was spray-drying, particularly for oil-containing microcapsule formulations.
Palmieri
G F
GF
Dipartimento di Scienze Chimiche, Università di Camerino, Italy.
Lauri
D
D
Martelli
S
S
Wehrle
P
P
D019840:2-Propanol / Q000737:chemistry; D000045:Acacia / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods*; D005612:Freeze Drying / Q000379:methods; D005780:Gelatin / Q000737:chemistry*; D006139:Guaiacol / Q000031:analogs & derivatives; D007052:Ibuprofen / Q000031:analogs & derivatives* / Q000737:chemistry; D007526:Isoelectric Point; D008854:Microscopy, Electron; D010316:Particle Size; D014466:Ultraviolet Rays; D014867:Water / Q000032:analysis
D000894:Anti-Inflammatory Agents, Non-Steroidal; D014867:Water; C020176:metoxibutropate; D006139:Guaiacol; D005780:Gelatin; D019840:2-Propanol; D007052:Ibuprofen