Detection of residual quadrupolar interaction in the human breast in vivo using sodium-23 multiple quantum spectroscopy.
Sodium multiple quantum (MQ) spectroscopy of the human breast in vivo was performed. Double quantum (DQ) filtered spectra were used to demonstrate the existence of a non-vanishing (residual) quadrupolar interaction in the tissue. Triple quantum (TQ) filtered spectra were used to measure the two time constants associated with the biexponential transverse relaxation times of sodium in biological tissues. The two time constants were found to be 0.64 and 26.57 msec. The potential applications of this finding are discussed.
Duvvuri
U
U
Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia 19104-6100, USA.
Leigh
J S
JS
Reddy
R
R
D016880:Anisotropy; D014408:Biomarkers, Tumor / Q000032:analysis*; D001940:Breast / Q000737:chemistry* / Q000473:pathology; D004867:Equipment Design; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods*; D012680:Sensitivity and Specificity; D012964:Sodium / Q000032:analysis*
D014408:Biomarkers, Tumor; D012964:Sodium