DNA-protein cross-links in different organs of mice induced by the combined action of zinc and gamma-irradiation.
Fractional whole-body gamma-irradiation of mice at total doses of 0. 5-1.5 Gy induces increased DNA-protein cross-links (DPCs) in thymus, spleen, and brain, whereas in liver no DPCs are detected. Chronic administration of zinc ions in drinking water at concentration 10 mg/liter for 20-30 days increased DPCs in thymus, spleen, brain, and liver of mice. The combined action of zinc ions and gamma-radiation produced a significantly lower amount of DPCs than was induced by the separate action of these agents.
Osipov
A N
AN
Moscow State Enterprise "United Ecological Technological Research Center on Neutralization of Radioactive Waste and Environmental Protection" (Radon), Moscow, 119121, Russia.
Sypin
V D
VD
Kolomijtseva
G Y
GY
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D004247:DNA / Q000187:drug effects* / Q000528:radiation effects*; D004249:DNA Damage; D005720:Gamma Rays; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011506:Proteins / Q000187:drug effects* / Q000528:radiation effects*; D013154:Spleen / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D013950:Thymus Gland / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D015032:Zinc / Q000494:pharmacology*
D011506:Proteins; D004247:DNA; D015032:Zinc