The effect of topical diltiazem on ocular hypertension induced by water loading in rabbits.
The aim of this work was to assess the effect of topical diltiazem on the ocular hypertension induced by water loading in rabbits. The effect of three different concentrations of diltiazem on the intraocular pressure rise produced by oral administration of tap water (60 ml/kg) was tested in groups of nine or ten rabbits each. When applied at the lowest concentration studied, topical diltiazem was found to enhance the intraocular pressure rise after water loading. In contrast, when applied at the highest concentration, diltiazem counteracted the ocular hypertension caused by water loading. Although diltiazem, and probably other calcium channel blockers, may be useful in the management of ocular hypertension, the data obtained suggest that these drugs may have complex actions on aqueous humor dynamics; therefore further studies in animal models for glaucoma should be carried out before their clinical evaluation in humans.
Santafé
J
J
Departamento de Farmacología, Facultad de Farmacia, Universidad del País Vasco, Vitoria, Spain.
Martínez de Ibarreta
M J
MJ
Segarra
J
J
Melena
J
J
D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D004110:Diltiazem / Q000627:therapeutic use*; D004195:Disease Models, Animal; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D009798:Ocular Hypertension / Q000139:chemically induced / Q000188:drug therapy*; D011817:Rabbits; D014867:Water / Q000494:pharmacology
D000959:Antihypertensive Agents; D014867:Water; D004110:Diltiazem