title: No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease.
abstract: Recent reports have suggested that variability in the alpha2-macroglobulin gene is a genetic risk factor for Alzheimer's disease. Here we have both tested a common polymorphism in the gene (I1000V) for association with the disease in a four-site case control study design, and tested the locus for linkage in a large series of sibpairs afflicted with late onset disease. Our results fail to show an association between this polymorphism and disease.
authors: Mayo Clinic Jacksonville, FL 32084, USA.
authors: F
authors: F
authors: Wavrant-DeVrièze
authors: V
authors: V
authors: Rudrasingham
authors: J C
authors: JC
authors: Lambert
authors: S
authors: S
authors: Chakraverty
authors: P
authors: P
authors: Kehoe
authors: R
authors: R
authors: Crook
authors: P
authors: P
authors: Amouyel
authors: W
authors: W
authors: Wu
authors: P
authors: P
authors: Holmans
authors: F
authors: F
authors: Rice
authors: J
authors: J
authors: Pérez-Tur
authors: B
authors: B
authors: Frigard
authors: J C
authors: JC
authors: Morris
authors: S
authors: S
authors: Carty
authors: D
authors: D
authors: Cottel
authors: N
authors: N
authors: Tunstall
authors: S
authors: S
authors: Lovestone
authors: R C
authors: RC
authors: Petersen
authors: M C
authors: MC
authors: Chartier-Harlin
authors: A
authors: A
authors: Goate
authors: M J
authors: MJ
authors: Owen
authors: J
authors: J
authors: Williams
authors: J
authors: J
authors: Hardy
mesh_terms: D017668:Age of Onset; D000483:Alleles; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D016022:Case-Control Studies; D005787:Gene Frequency; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008875:Middle Aged; D009679:Nuclear Family; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D000511:alpha-Macroglobulins / Q000235:genetics*
chemical_list: D001057:Apolipoproteins E; D000511:alpha-Macroglobulins