Superior cervical ganglionectomy-induced lowering of intraocular pressure in rabbits: role of prostaglandins and neuropeptide Y.
At 22-24 h after unilateral ganglionectomy (SX), intraocular pressure (IOP) was significantly (p < 0.001) reduced in SX eyes compared either with the contralateral, normally innervated eyes or with baseline measurements. SX raised prostaglandin E2 (PGE2), PGF2alpha, and neuropeptide Y (NPY) concentrations in the aqueous humor but reduced these levels in the iris-ciliary body. At 22-24 h after bilateral SX, flurbiprofen (0.03%) significantly (p < 0.001) inhibited the reduction of IOP and the elevation of PGE2 and PGF2alpha levels in the aqueous humor. We conclude that PGs mediate the reduction of IOP at 22-24 h after SX.
Zhan
G L
GL
Department of Ophthalmology, University of Nebraska Medical Center, Omaha, USA.
Ohia
S E
SE
Camras
C B
CB
Ohia
E O
EO
Wang
Y L
YL
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D005260:Female; D005480:Flurbiprofen / Q000494:pharmacology; D015171:Ganglionectomy / Q000009:adverse effects*; D007429:Intraocular Pressure; D009478:Neuropeptide Y / Q000378:metabolism*; D011453:Prostaglandins / Q000378:metabolism*; D011817:Rabbits; D017783:Superior Cervical Ganglion / Q000187:drug effects / Q000601:surgery
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009478:Neuropeptide Y; D011453:Prostaglandins; D005480:Flurbiprofen