title: [Genetic linkage of polymorphisms of type I angiotensin II receptor gene to Chinese Han hypertension].
abstract: OBJECTIVE
  To observe the CA repeat polymorphism of the type I angiotensin II receptor gene on Chinese Han people, and evaluate the genetic linking to hypertension.
  
  
  METHODS
  The CA repeat polymorphism at 3'-flanking region of AT1R gene was studied by amplified fragment length polymorphism (Amp-FLP ) in Chinese Han people from Shandong and Xi'an.
  
  
  RESULTS
  There were 9 alleles ranging from 130bp to 146bp in all subjects. The allele frequencies were 0.01 to 0.38, and allele A4 was more frequent in the control. The heterozygosity of CA repeat locus was 0.789, the polymorphic information content, 0.746. There was no significant difference in distribution of CA repeat polymorphism genotype between different regions in same ethnic (P>0. 05), but the allele frequency of CA repeat polymorphism in hypertensive group was significantly different from that of control (P<0.05). There was no detectable distortion from Hardy-Weinberg equilibrium in both groups.
  
  
  CONCLUSIONS
  The results suggest that CA repeat polymorphism of AT1R gene be associated with Chinese Han hypertensive people.
authors: Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 100037, P. R. China. aihuacn@hot.mail.com
authors: A
authors: A
authors: Hu
authors: X
authors: X
authors: Zhou
authors: X
authors: X
authors: Ren
authors: Z
authors: Z
authors: Cui
authors: R
authors: R
authors: Hui
authors: L
authors: L
authors: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D002681:China / Q000208:ethnology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D044140:Receptor, Angiotensin, Type 1; D044139:Receptor, Angiotensin, Type 2; D011945:Receptors, Angiotensin / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid
chemical_list: D044140:Receptor, Angiotensin, Type 1; D044139:Receptor, Angiotensin, Type 2; D011945:Receptors, Angiotensin