Prognostic assessment of the Durie and Salmon staging system in patients with multiple myeloma.
In a prospective study, covering a 10-year period, 109 patients with multiple myeloma (56 men and 53 women of mean age of 62) were followed. The patients were grouped according to the staging system of Durie & Salmon. They were treated uniformally with monochemotherapy with Cyclophosphamid, Melphalan and Glicocorticosteroids. The median survival for the different clinical stages was: I--53 months, II--31 and III--24 months. Significant difference between stages II and III with 98 patients (89.9%), was not found. Authentically, patients in II A compared to II B clinical stage had higher median survival of 40 and 26 months, respectively. So was IIIA compared to IIIB--38 and 18 months. It was found that the prognosis for the life expectancy of the patients depended to a greater degree on the extent of the renal function impairment at the time of diagnosis of the process, e.g., on the A and B substage (serum creatinin level > 160 mmol/l) than on the size of the tumour mass, respectively the clinical stage according to Durie & Salmon system.
Spasov
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E
Department of Haematology, Higher Medical Institute, Plovdiv, Bulgaria.
Goranova
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V
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000401:mortality / Q000473:pathology*; D009367:Neoplasm Staging / Q000379:methods*; D011379:Prognosis; D011446:Prospective Studies; D015996:Survival Rate