title: Evidence for a polyclonal etiology of palmar fibromatosis.
abstract: X chromosome inactivation patterns at the androgen receptor locus were evaluated to determine clonality in microdissected lesional tissue and in leukocytes from 2 women with Dupuytren's disease. The tissue from both patients generated a polyclonal pattern of X chromosome inactivation of the human androgen receptor gene. This finding supports a polyclonal reactive process as the underlying etiology for palmar fibromatosis.
authors: Department of Orthopaedics, University of Washington School of Medicine, Seattle, USA.
authors: H A
authors: HA
authors: Chansky
authors: T E
authors: TE
authors: Trumble
authors: E U
authors: EU
authors: Conrad
authors: J F
authors: JF
authors: Wolff
authors: L W
authors: LW
authors: Murray
authors: W H
authors: WH
authors: Raskind
mesh_terms: D004303:Dosage Compensation, Genetic; D004387:Dupuytren Contracture / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D007962:Leukocytes; D008875:Middle Aged; D011944:Receptors, Androgen / Q000235:genetics*; D015183:Restriction Mapping
chemical_list: D011944:Receptors, Androgen