Multiple vs. single betamethasone therapy. Neonatal and maternal effects.
OBJECTIVE
To identify potential neonatal benefits and possible neonatal and maternal complications associated with repeated use of antenatal corticosteroids.


METHODS
A retrospective chart review was done on all gravidas < 34 weeks who were hospitalized and received antenatal betamethasone at our institution between January 1, 1992 and April 30, 1996. Regression analysis was performed to investigate the relationship between single vs. multiple course of betamethasone and multiple variables.


RESULTS
After controlling for significant covariates, multiple courses of betamethasone were associated with a decrease in oxygen use (P < .01). A nonsignificant decline in respiratory distress syndrome and assisted ventilation was noted. No effect on birth weight or maternal or neonatal infection was seen.


CONCLUSIONS
Repeated use of betamethasone is associated with a significant decrease in oxygen use in the preterm neonate. No significant maternal or neonatal complications were found. A prospective, randomized trial is necessary.
Pratt
L
L
Department of Obstetrics and Gynecology, University of Wisconsin, Madison, USA. prattl@hsm13.hsmnet.com
Waschbusch
L
L
Ladd
W
W
Gangnon
R
R
Hendricks
S K
SK
D000328:Adult; D000704:Analysis of Variance; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001623:Betamethasone / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D005325:Fetal Organ Maturity / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D008168:Lung / Q000187:drug effects / Q000196:embryology*; D008297:Male; D008499:Medical Records; D007752:Obstetric Labor, Premature; D010101:Oxygen Consumption / Q000187:drug effects; D011247:Pregnancy; D011295:Prenatal Care; D012127:Respiratory Distress Syndrome, Newborn / Q000517:prevention & control*; D012129:Respiratory Function Tests; D012189:Retrospective Studies
D000893:Anti-Inflammatory Agents; D001623:Betamethasone