Immunocytochemical detection of insulin-like growth factor II (IGF-II) in choroid plexus papilloma: a possible marker for differential diagnosis.
BACKGROUND
Insulin-like growth factor II (IGF-II) has been detected in the choroid plexus of animals by means of immunohistochemistry and in situ hybridization, and this factor is thought to play an important role in the central nervous system (CNS). Little is known, however, about the presence and localization of this substance in the choroid plexus and in choroid plexus papilloma in humans.


METHODS
5 normal choroid plexus and 10 choroid plexus papillomas were examined for IGF-II by immunocytochemistry. IGF-II was not detected in normal human choroid plexus, whereas it was found in choroid plexus papilloma. Furthermore, to assess the possibility that IGF-II could serve as an immunohistological marker of choroid plexus papilloma, we used the same technique to examine paraffin-embedded samples from various kinds of brain tumors.


CONCLUSIONS
Our results suggest that IGF-II may be a useful marker for choroid plexus papilloma in differential diagnosis.
Kubo
S
S
Department of Neurosurgery, Sakai Municipal Hospital, Osaka, Japan.
Ogino
S
S
Fukushima
T
T
Maruno
M
M
Yoshimine
T
T
Hasegawa
H
H
D000293:Adolescent; D000328:Adult; D014408:Biomarkers, Tumor; D016022:Case-Control Studies; D016545:Choroid Plexus Neoplasms / Q000737:chemistry / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D005910:Glioma / Q000737:chemistry / Q000175:diagnosis*; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D007335:Insulin-Like Growth Factor II / Q000032:analysis*; D008297:Male; D008875:Middle Aged
D014408:Biomarkers, Tumor; D007335:Insulin-Like Growth Factor II