Multiple signals converging on NF-kappaB.
The recent identification of molecular components of the signal transduction pathway regulating activation of nuclear factor-kappaB (NF-kappaB) in response to cytokines such as tumor necrosis factor alpha and interleukin-1beta allows the evaluation of how other diverse stimuli impinge on the NF-kappaB activation pathway. These studies suggest a basis for specificity in activation of specific Rel-related family members and the genetic responses they promote.
Mercurio
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F
Signal Pharmaceuticals Inc, 5555 Oberlin Drive, San Diego, CA 92121, USA. fmercuri@signalpharm.com
Manning
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AM
D000595:Amino Acid Sequence; D000818:Animals; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000502:physiology; D004268:DNA-Binding Proteins / Q000502:physiology; D005314:Embryonic and Fetal Development; D005121:Extremities / Q000196:embryology; D005786:Gene Expression Regulation / Q000502:physiology*; D020672:I-kappa B Proteins; D007249:Inflammation / Q000503:physiopathology; D051379:Mice; D008817:Mice, Mutant Strains; D008954:Models, Biological; D008969:Molecular Sequence Data; D009024:Morphogenesis; D016328:NF-kappa B / Q000502:physiology*; D010010:Osteoclasts / Q000166:cytology; D011494:Protein Kinases / Q000502:physiology; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction / Q000502:physiology*; D013312:Stress, Physiological / Q000503:physiopathology; D014158:Transcription, Genetic / Q000502:physiology*
D004268:DNA-Binding Proteins; D020672:I-kappa B Proteins; D016328:NF-kappa B; D011494:Protein Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases