The pharmacokinetics of promethazine after intravenous administration in camels.
The pharmacokinetics of promethazine were determined in seven camels (Camelus dromedarius) after an intravenous dose of 0.5 mg kg body weight.-1 The data obtained (median and range) were as follows: the elimination half-life (t1/2 beta) was 5.62 (2.84-6.51) h; the steady state volume of distribution (Vdss) was 8.90 (7.10-12.00) L kg-1, total body clearance (CT) was 24.5 (17.22-33.65) ml kg-1 min-1 and renal clearance (Clr) was 4.81 (1.97-5.48) ml kg-1 min-1.
Wasfi
I A
IA
Camelracing Laboratory, Forensic Science Laboratory, P O Box 253, Abu Dhabi, United Arab Emirates. iawasfi@emirates.net.ae
Barezaiq
I M
IM
Alkatheeri
N
N
Hadi
A A
AA
Boni
N S
NS
Almuhrami
A M
AM
Elghazali
M
M
D000818:Animals; D002162:Camelus; D006207:Half-Life; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D007275:Injections, Intravenous; D008297:Male; D008657:Metabolic Clearance Rate; D011398:Promethazine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D006634:Histamine H1 Antagonists; D011398:Promethazine