Pre-eclampsia associated with increased lipid peroxidation and decreased serum vitamin E levels.
OBJECTIVE
To evaluate lipid peroxidation and the serum levels of the antioxidant vitamin E in pre-eclampsia according to the disease severity.


METHODS
Serum malondialdehyde (MDA) and vitamin E levels were measured in 18 pre-eclamptic, 15 eclamptic and 25 normotensive pregnant women in Ondokuz Mayis University Hospital. The correlation of these levels with the factors indicating disease severity was tested. Mann-Whitney U-test and correlation coefficients were used for the statistical analysis.


RESULTS
Both the pre-eclamptic and the eclamptic patients had higher MDA and lower vitamin E levels compared with control (P < 0.05); but these values were not significantly different from each other (P > 0.05). MDA levels were significantly correlated with the systolic and diastolic blood pressure (BP) and with serum uric acid levels. There was significant but negative correlation with the vitamin E levels.


CONCLUSIONS
There is an imbalance between lipid peroxidation and serum vitamin E levels in pre-eclampsia and eclampsia. Increased lipid peroxidation is well correlated with the increase in systolic and diastolic BP measurements and serum uric acid levels.
Yanik
F F
FF
Department of Obstetrics and Gynecology, Medical Faculty of Ondokuz Mayis University, Samsun, Turkey.
Amanvermez
R
R
Yanik
A
A
Celik
C
C
Kökçü
A
A
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D004461:Eclampsia / Q000097:blood* / Q000209:etiology; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000097:blood; D011225:Pre-Eclampsia / Q000097:blood* / Q000209:etiology; D011247:Pregnancy; D011446:Prospective Studies; D012720:Severity of Illness Index; D014810:Vitamin E / Q000097:blood*; D014811:Vitamin E Deficiency / Q000150:complications
D014810:Vitamin E; D008315:Malondialdehyde