title: [Obstructive sleep apnea syndrome caused by occupational exposure to solvents].
abstract: METHODS
  A 52-year-old man working in a chemical laboratory was referred with the possible diagnosis of toxic encephalopathy. For 17 years he had been exposed to high concentrations of perchlorethylene and n-butanol vapours which every day had caused acute symptoms of organic solvent intoxication. Current complaints were autonomic nervous system symptoms, loss of concentration and memory, and fatigue in the second half of the day. The patient was obese but in good general condition.
  
  
  METHODS
  Neuropsychiatric examination confirmed the reported loss of concentration and planning ability at work. The polysomnogram indicated an increased number of largely obstructive apnoea attacks.
  
  
  METHODS
  As the patients had an obstructive type of sleep apnoea treatment consisted of positive pressure ventilation at night and weight reduction. The occupational exposure to organic solvents was the likely cause.
  
  
  CONCLUSIONS
  As the symptoms of encephalopathy and sleep apnoea syndrome overlap, the latter should be considered before an encephalopathy is diagnosed. Because a rare cause of the sleep apnoea syndrome is prolonged and marked occupational exposure to organic solvents this should be asked about in taking the history. If indeed there has been occupational exposure, it should cease at once and be reported.
authors: Institut für Arbeits-, Sozial- und Umweltmedizin, Johannes Gutenberg-Universität Mainz.
authors: A
authors: A
authors: Muttray
authors: W
authors: W
authors: Randerath
authors: K H
authors: KH
authors: Rühle
authors: H
authors: H
authors: Gajsar
authors: P
authors: P
authors: Gerhardt
authors: W
authors: W
authors: Greulich
authors: J
authors: J
authors: Konietzko
mesh_terms: D020001:1-Butanol / Q000009:adverse effects*; D001927:Brain Diseases / Q000139:chemically induced / Q000175:diagnosis; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D016273:Occupational Exposure; D017286:Polysomnography; D011175:Positive-Pressure Respiration; D011581:Psychological Tests; D012891:Sleep Apnea Syndromes / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D012997:Solvents / Q000009:adverse effects*; D013750:Tetrachloroethylene / Q000009:adverse effects*; D013997:Time Factors; D015431:Weight Loss
chemical_list: D012997:Solvents; D020001:1-Butanol; D013750:Tetrachloroethylene