Examining the immune response in sentinel lymph nodes of mice and men.
Recently, it was recognized that an immune response develops along one of two major pathways. One leads to a destructive immune response (type 1), while the alternative leads to a nondestructive immune response (type 2). Our studies in animal models suggest that therapeutic vaccines induce a tumor-specific type 1 immune response while ineffective vaccines induce a type 2 response. These results have led us to examine the immune response in sentinel lymph nodes draining tumor vaccines of patients entered onto clinical trials for melanoma, breast and renal cell cancer.
Chu
Y
Y
Robert W. Franz Cancer Research Center, Earle A. Chiles Research Institute, Providence Poartland Medical Center, Portland, OR 97213, USA.
Hu
H M
HM
Winter
H
H
Wood
W J
WJ
Doran
T
T
Lashley
D
D
Bashey
J
J
Schuster
J
J
Wood
J
J
Lowe
B A
BA
Vetto
J T
JT
Weinberg
A D
AD
Puri
R
R
Smith
J W
JW
Urba
W J
WJ
Fox
B A
BA
D000818:Animals; D001943:Breast Neoplasms / Q000276:immunology* / Q000628:therapy; D019496:Cancer Vaccines; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000276:immunology* / Q000628:therapy; D008198:Lymph Nodes / Q000276:immunology*; D008207:Lymphatic Metastasis / Q000276:immunology*; D008297:Male; D008545:Melanoma / Q000276:immunology* / Q000628:therapy; D051379:Mice
D019496:Cancer Vaccines