title: Transcription initiation in Archaea: facts, factors and future aspects.
abstract: The basal apparatus for transcription initiation in Archaea is more closely related to the eukaryal than to the bacterial counterpart. The understanding of archaeal transcription initiation has been deepened by recent advances, which include genome sequencing, biochemical approaches and the structure determination of a protein DNA complex. Archaeal promoter elements, transcription factors, RNA polymerase and their interactions are discussed and compared with the eukaryal situation. It is emerging that transcription initiation is not uniform in Archaea. A minimal set of promoter elements and transcription factors is conserved, but the relative importance for transcription initiation can vary. Furthermore, additional basal transcription factors and promoter elements seem to be crucial in subgroups of Archaea. Finally, some aspects of global as well as gene-specific transcriptional regulation are discussed.
authors: Universität Frankfurt, Biozentrum Niederursel, Institut für Mikrobiologie, Germany. soppa@em.uni-frankfurt.de
authors: J
authors: J
authors: Soppa
mesh_terms: D001105:Archaea / Q000235:genetics* / Q000502:physiology*; D019843:Archaeal Proteins; D001419:Bacteria / Q000235:genetics; D012321:DNA-Directed RNA Polymerases / Q000502:physiology; D005057:Eukaryotic Cells; D005809:Genes, Regulator / Q000502:physiology; D008957:Models, Genetic; D009687:Nuclear Proteins / Q000502:physiology; D011401:Promoter Regions, Genetic; D016385:TATA Box / Q000502:physiology; D035581:Transcription Factor TFIIB; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic / Q000502:physiology*
chemical_list: D019843:Archaeal Proteins; D009687:Nuclear Proteins; D035581:Transcription Factor TFIIB; D014157:Transcription Factors; C106466:transcription factor B, Archaea; D012321:DNA-Directed RNA Polymerases