Leukemic phase of mantle cell lymphoma, blastoid variant.
Six patients with mantle cell lymphoma, blastoid variant, involving the blood are described. The circulating blast-like cells suggested the possibility of acute leukemias, chronic lymphoproliferative disorders or peripheralized lymphomas. The WBC counts ranged from 3,700 to 249,000/microL (3.7-249.0 x 10(9)/L) and the absolute lymphocyte counts from 1,000 to more than 200,000/microL (1.0 to > 200.0 x 10(9)/L). The peripheral blood smears showed a spectrum of cells, from small mature lymphocytes with irregular nuclei to medium-sized lymphocytes with blast-like chromatin. However, the morphologic features in a lymph node biopsy specimen and the immunophenotype confirmed a diagnosis of mantle cell lymphoma, blastoid variant. By flow cytometry the lymphoma cells expressed B-cell-associated antigens (CD19, CD20 and CD22), coexpressed CD5, lacked CD23, and expressed moderate intensity monoclonal surface immunoglobulin and CD20. Cytogenetic analysis showed the characteristic t(11;14) in 2 of 4 analyzed specimens. Mantle cell lymphoma, blastoid variant, is part of the differential diagnosis for blast-like cells.
Singleton
T P
TP
Department of Pathology, University of Michigan Medical Center, Ann Arbor, USA.
Anderson
M M
MM
Ross
C W
CW
Schnitzer
B
B
D000368:Aged; D000911:Antibodies, Monoclonal / Q000032:analysis; D000944:Antigens, Differentiation, B-Lymphocyte / Q000032:analysis; D001854:Bone Marrow Cells / Q000473:pathology; D002467:Cell Nucleus / Q000473:pathology; D002843:Chromatin / Q000473:pathology; D005260:Female; D005434:Flow Cytometry; D006529:Hepatomegaly; D006801:Humans; D016130:Immunophenotyping; D007958:Leukocyte Count; D008198:Lymph Nodes / Q000473:pathology; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000473:pathology / Q000648:ultrastructure; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D013163:Splenomegaly
D000911:Antibodies, Monoclonal; D000944:Antigens, Differentiation, B-Lymphocyte; D002843:Chromatin