Epidermal growth factor receptors: critical mediators of multiple receptor pathways.
Recently, the receptor for epidermal growth factor (EGF) was identified as a downstream element in different signaling pathways. This expanded its classical function as a receptor for EGF-like ligands to a role as mediator of diverse signaling systems and as a switch point of a cellular communication network. In addition, several downstream targets, (e.g. Smad proteins and STATs) into which signals from synergistic and antagonistic signaling pathways converge, were identified.
Hackel
P O
PO
Department of Molecular Biology, Max Planck Institut für Biochemie, AmKlopferspitz 18A, 82152 Martinsried, Germany.
Zwick
E
E
Prenzel
N
N
Ullrich
A
A
D000818:Animals; D017209:Apoptosis; D019281:Dimerization; D004789:Enzyme Activation; D004815:Epidermal Growth Factor / Q000502:physiology*; D066246:ErbB Receptors / Q000737:chemistry / Q000502:physiology*; D008954:Models, Biological; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D017027:Protein Tyrosine Phosphatases / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D004815:Epidermal Growth Factor; D066246:ErbB Receptors; D017027:Protein Tyrosine Phosphatases