title: Benfluorex: what use? A second look. Poor assessment file.
abstract: The clinical file on the value of benfluorex for hypertriglyceridaemia is highly inadequate.  No clinical trials have been done with morbidity or mortality as end points.  Available placebo-controlled trials are small, methodologically weak in most cases, and their results regarding triglyceride levels are contradictory.  None of the three trials comparing benfluorex with a fibrate is interpretable, because of methodological problems.
mesh_terms: D000144:Acids, Acyclic / Q000627:therapeutic use; D001067:Appetite Depressants / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D005277:Fenfluramine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005602:France; D006801:Humans; D015228:Hypertriglyceridemia / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D010919:Placebos; D016896:Treatment Outcome; D014481:United States
chemical_list: D000144:Acids, Acyclic; D001067:Appetite Depressants; D000960:Hypolipidemic Agents; D010919:Placebos; D005277:Fenfluramine