Antiperinuclear factor and antibodies to the stratum corneum of rat esophagus in juvenile idiopathic arthritis.
We analyzed the frequency and clinical correlates of antiperinuclear factor (APF) and antibodies to the stratum corneum of rat esophagus in 86 children with juvenile idiopathic arthritis (JIA), 32 children with juvenile systemic lupus erythematosus, and 52 healthy children. Forty-two patients with JIA (49%) were positive for APF. No association was observed between APF and current age, sex, JIA subtype, age at disease onset, or disease duration. APF was found in one patient with juvenile systemic lupus erythematosus and in no healthy child. Antibodies to the stratum corneum of rat esophagus were detected in 3 patients with polyarticular JIA. APF may be a valuable tool in the differential diagnosis of JIA.
Serra
C R
CR
Division of Rheumatology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Rodrigues
S H
SH
Sztajnbok
F R
FR
Silva
N P
NP
Andrade
L E
LE
D000818:Animals; D000906:Antibodies / Q000097:blood*; D000974:Antibodies, Antinuclear / Q000097:blood*; D001171:Arthritis, Juvenile / Q000097:blood*; D002675:Child, Preschool; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007633:Keratins / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000097:blood; D008297:Male; D051381:Rats; D012016:Reference Values; D012217:Rheumatoid Factor / Q000097:blood
D000906:Antibodies; D000974:Antibodies, Antinuclear; C030902:antiperinuclear factor; D007633:Keratins; D012217:Rheumatoid Factor