[Reagin sensitizations and date of birth. Differences in function according to family history].
BACKGROUND
Atopy remains a hazy concept, as research in genetic markers is still not sufficiently elaborated due to multiple physiopathological mechanisms and mixing of patients. The aim of this work was to demonstrate this hypothesis by comparing birthdates according to family history and serum IgE to house dust mite and/or timothy grass pollen.


METHODS
Rasts d1 and g6 were measured in the serum of 5,468 subjects, 2 to 18 years of age. The quotient of sensitizations to Dermatophagoides pteronyssinus and timothy grass pollen was established, month by month, according to family history. Representative curves were smoothed by computer.


RESULTS
The circannual rhythm of quotients was remarkably similar within both groups of subjects with or without family history, with a time lag of 2 to 3 months. Subjects without family history were born 2 to 3 months before subjects with family history, i.e., they were 2 to 3 months older at the time of antigenic stimulation.


CONCLUSIONS
Mechanisms by which subjects have been sensitized, still unknown, happen in different times according to family history. These findings suggest several genetic factors.
de Montis
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Service de pédiatrie générale, hôpital Saint-Vincent-de-Paul, Paris, France.
D000293:Adolescent; D000367:Age Factors; D000818:Animals; D002648:Child; D002675:Child, Preschool; D004391:Dust / Q000009:adverse effects; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000097:blood / Q000235:genetics* / Q000276:immunology*; D007073:Immunoglobulin E / Q000097:blood* / Q000276:immunology; D007743:Labor, Obstetric; D008487:Medical History Taking; D008925:Mites; D010375:Pedigree; D006109:Poaceae; D011058:Pollen / Q000009:adverse effects; D011247:Pregnancy; D011935:Reagins / Q000097:blood* / Q000276:immunology; D012189:Retrospective Studies; D012307:Risk Factors; D012621:Seasons; D013997:Time Factors
D004391:Dust; D011935:Reagins; D007073:Immunoglobulin E