Linkage of the nuclear hormone receptor genes NR1D2, THRB, and RARB: evidence for an ancient, large-scale duplication.
The THRA gene encoding thyroid hormone receptor alpha shares an unusual partial overlap with the NR1D1 gene encoding the orphan receptor Rev-ErbAalpha. Though THRA and NR1D1 have close relatives in THRB and NR1D2, which encode TRbeta and Rev-ErbAbeta, these beta isoforms do not share an analogous overlap. Here we report that the human THRB and NR1D2 genes are separated by approximately 1 Mb on chromosome 3 and that these two genes are also linked to the RARB gene, which encodes retinoic acid receptor beta. Since previous results indicate that the THRA/NR1D1 locus is also linked to the RARA gene, these results suggest that the two receptor gene clusters were generated by a single large-scale duplication.
Koh
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Department of Cell Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.
Moore
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D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D020451:Contig Mapping; D004268:DNA-Binding Proteins / Q000235:genetics; D020440:Gene Duplication; D008040:Genetic Linkage; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics*; D018168:Receptors, Retinoic Acid / Q000235:genetics; D011988:Receptors, Thyroid Hormone / Q000235:genetics
D004268:DNA-Binding Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D018168:Receptors, Retinoic Acid; D011988:Receptors, Thyroid Hormone