[The role of prostaglandin E2 and its receptors in the regulation of osmotic permeability of the frog bladder epithelium].
Arginine-vasotocin-induced enhancement of osmotic water flow was inhibited by PGE2, sulprostone, M&B 28767 and 17-phenyl-omega-trinor PGE2. The inhibitory action of these agents except M&B 28767 was more obvious when the osmotic water flow was activated by dibutyryl-cAMP. The findings suggest that, in the frog urinary bladder, the inhibitory effect of the PGE2 on arginine-vasotocin-induced water flow appears to be mediated via two receptor subtypes coupled with different secondary messengers. The inhibition-sensitive targets are localised both on pre- and post-cAMP steps of the hormonal signal transduction pathway.
Lavrova
E A
EA
I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Acad. Sci., St. Petersburg, Russia.
Parnova
R G
RG
D000818:Animals; D015232:Dinoprostone / Q000502:physiology*; D009995:Osmosis; D009997:Osmotic Pressure; D011896:Rana temporaria; D018078:Receptors, Prostaglandin E / Q000502:physiology*; D058307:Receptors, Prostaglandin E, EP2 Subtype; D001743:Urinary Bladder / Q000378:metabolism*; D019459:Urothelium / Q000378:metabolism; D014668:Vasotocin / Q000037:antagonists & inhibitors / Q000494:pharmacology; D014867:Water / Q000378:metabolism
D018078:Receptors, Prostaglandin E; D058307:Receptors, Prostaglandin E, EP2 Subtype; D014867:Water; D015232:Dinoprostone; D014668:Vasotocin