title: [Effect if 6-week nutritional intervention with enzymatic yeast cells and antioxidants on exercise stress and antioxidant status].
abstract: The aim of the present study was to investigate the influence of a yeast cell preparation rich in antioxidant vitamins, antioxidant enzymes, trace elements and minerals on the exercise-induced stress reaction and antioxidant status. The study was carried out in a non-blinded, controlled design. After a 6 week pre-ingestion period, 9 highly endurance-trained athletes took the preparation twice daily for another 6 weeks. After each phase venous blood samples were drawn in the resting state after an overnight fast followed by a strenuous 15 km cross country race. 1 h after the exercise venous blood sampling was repeated. Compared to the pre-ingestion period, the following significant alterations could be detected after 6 weeks of ingestion: 1) In the resting state, soluble interleukin-2 receptor (p < 0.05) and plasma fibrinogen (p < 0.01) were shown to be lower whereas plasma fibronectin was increased (p < 0.01). 2) 1 h after the race the significant difference in fibrinogen and fibronectin was confirmed. In addition myoglobin (p < 0.01) and CKMM3 (p < 0.05) as well as mangan superoxid dismutase (p < 0.05) were reduced. In conclusion, the 6-week ingestion-period resulted in an improvement of the systemic and muscular stress reaction. In addition, the decrease in mangan superoxide dismutase concentration can be interpreted as a sign of reduced free radical stress. However, these preliminary results have to be confirmed in larger trials in blinded designs. In addition, there seems to be a rationale for testing the effects of yeast-cell preparations in patients with chronic degenerative diseases as some of the investigated parameters are involved in the pathophysiology of such illnesses.
authors: Abteilung für Prävention, Rehabilitation und Sportmedizin, Medizinischen Universitätsklinik Freiburg, Deutschland. dani@msm1.ukl.uni-freiburg.de
authors: D
authors: D
authors: König
authors: J
authors: J
authors: Keul
authors: H
authors: H
authors: Northoff
authors: M
authors: M
authors: Halle
authors: A
authors: A
authors: Berg
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage* / Q000378:metabolism; D006801:Humans; D008297:Male; D010807:Physical Endurance / Q000187:drug effects / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012420:Running / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000201:enzymology*; D013312:Stress, Physiological / Q000503:physiopathology*; D016896:Treatment Outcome; D015002:Yeast, Dried / Q000008:administration & dosage*
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species