Correlation of tumor suppressor P53 RNA expression with human immunodeficiency virus disease in rapid and slow progressors.
OBJECTIVE
To determine the relation between P53 tumor suppressor RNA expression and human immunodeficiency virus (HIV) disease progression.


METHODS
A quantitative assay of P53 RNA expression was used to analyze a cohort of HIV-negative persons. The assay was then used in longitudinal and cross-sectional studies of HIV slow and rapid progressors.


RESULTS
We demonstrate first that P53 expression in peripheral blood mononuclear cells from HIV-1-seronegative persons is minimal. Longitudinal studies in a small cohort of HIV-1-infected slow and rapid progressors reveal that rapid progressors seem to have greater P53 RNA expression over time. This was validated in a cohort of 26 HIV-1-infected persons in whom the expression of P53 RNA was significantly greater in persons with rapid progression of HIV-1 disease.


CONCLUSIONS
These data suggest that P53 RNA expression may play a role in the pathogenesis of HIV-1 disease, though the mechanism of this interaction remains unknown.
McLinden
R J
RJ
Department of Medicine, University of Maryland, Baltimore, USA.
Lewis
B
B
Michael
N L
NL
Redfield
R R
RR
Birx
D L
DL
Kim
J H
JH
D000818:Animals; D018791:CD4 Lymphocyte Count; D016466:CHO Cells; D002453:Cell Cycle; D006224:Cricetinae; D018450:Disease Progression; D015870:Gene Expression; D016147:Genes, Tumor Suppressor; D015658:HIV Infections / Q000097:blood / Q000235:genetics* / Q000276:immunology / Q000821:virology; D018023:HIV Seronegativity; D015497:HIV-1 / Q000502:physiology; D006801:Humans; D012333:RNA, Messenger / Q000032:analysis; D016159:Tumor Suppressor Protein p53 / Q000032:analysis / Q000097:blood / Q000235:genetics*; D019562:Viral Load
D012333:RNA, Messenger; D016159:Tumor Suppressor Protein p53