ATP synthase: two motors, two fuels.
FoF1 ATPase is the universal protein responsible for ATP synthesis. The enzyme comprises two reversible rotary motors: Fo is either an ion 'turbine' or an ion pump, and F1 is either a hydrolysis motor or an ATP synthesizer. Recent biophysical and biochemical studies have helped to elucidate the operating principles for both motors.
Oster
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Departments of Molecular & Cellular Biology, College of Natural Resources, University of California, Berkeley, California 94720-3112, USA. goster@nature.berkeley.edu
Wang
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H
D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000818:Animals; D001665:Binding Sites; D004734:Energy Metabolism; D005057:Eukaryotic Cells / Q000201:enzymology; D006868:Hydrolysis; D017136:Ion Transport; D046911:Macromolecular Substances; D008958:Models, Molecular; D020409:Molecular Motor Proteins; D011485:Protein Binding; D011487:Protein Conformation; D006180:Proton-Translocating ATPases / Q000737:chemistry*; D012399:Rotation; D013269:Stochastic Processes; D013329:Structure-Activity Relationship
D046911:Macromolecular Substances; D020409:Molecular Motor Proteins; D000255:Adenosine Triphosphate; D006180:Proton-Translocating ATPases