title: Radial basis function neural networks for the characterization of heart rate variability dynamics.
abstract: This study introduces new neural network based methods for the assessment of the dynamics of the heart rate variability (HRV) signal. The heart rate regulation is assessed as a dynamical system operating in chaotic regimes. Radial-basis function (RBF) networks are applied as a tool for learning and predicting the HRV dynamics. HRV signals are analyzed from normal subjects before and after pharmacological autonomic nervous system (ANS) blockade and from diabetic patients with dysfunctional ANS. The heart rate of normal subjects presents notable predictability. The prediction error is minimized, in fewer degrees of freedom, in the case of diabetic patients. However, for the case of pharmacological ANS blockade, although correlation dimension approaches indicate significant reduction in complexity, the RBF networks fail to reconstruct adequately the underlying dynamics. The transient attributes of the HRV dynamics under the pharmacological disturbance is elucidated as the explanation for the prediction inability.
authors: Department of Medical Physics, School of Medicine, University of Patras, Greece. bezer@patreas.upatras.gr
authors: A
authors: A
authors: Bezerianos
authors: S
authors: S
authors: Papadimitriou
authors: D
authors: D
authors: Alexopoulos
mesh_terms: D001285:Atropine / Q000494:pharmacology; D001342:Autonomic Nervous System Diseases / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000503:physiopathology; D004562:Electrocardiography; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D016571:Neural Networks, Computer; D010276:Parasympatholytics / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D013565:Sympatholytics / Q000494:pharmacology
chemical_list: D010276:Parasympatholytics; D013565:Sympatholytics; D001285:Atropine; D011433:Propranolol