Applicability of a scale-up methodology for wet granulation processes in Collette Gral high shear mixer-granulators.
This study investigates the extension of a scale-up methodology based on dimensionless power relationships, to a series of vertical mixer-granulators in which the bowl is removable, i.e. both impeller and chopper blades are mounted on top-driven vertical shafts positioned through the lid. Granulation runs were carried out in several bowl sizes belonging to the series of Collette Gral mixer-granulators, ranging from 8 to 600 l capacities. It was shown that under certain conditions a common scale-up master curve could be drawn from the data gathered for each bowl, thus permitting the use of such a curve for the determination of mixer-granulator power consumption at a defined granulation end-point. The results also helped to clarify the concept of similitude, both geometrical and dynamic, which is implied in the methodology. The importance of wall slippage (as promoted by the insertion of a PTFE lining into the bowls) and batch size are illustrated.
Faure
A
A
Drug Delivery Group, Postgraduate Studies in Pharmaceutical Technology, School of Pharmacy, University of Bradford, Bradford, UK.
Grimsey
I M
IM
Rowe
R C
RC
York
P
P
Cliff
M J
MJ
D000465:Algorithms; D004339:Drug Compounding / Q000295:instrumentation*; D004345:Drug Industry / Q000295:instrumentation*; D011138:Polytetrafluoroethylene; D011208:Powders
D011208:Powders; D011138:Polytetrafluoroethylene