[The effect of compounds with antioxidant properties on thrombocyte functional activity].
The effect of antioxidant compounds ionol and mexidol and the new phenol derivative N9-imidazo-(1,2 alpha)-benzymidazol (PY-185) on the functional activity of blood platelets was studied. All the compounds under study effectively inhibited blood platelet aggregation both in vitro and in administration into rats, a result of which the blood thrombogenic potential reduced.
Spasov
A A
AA
Department of Pharmacology, Volgograd Medical Academy, Russia.
Ostrovskiĭ
O V
OV
Ivakhnenko
I V
IV
Kosolapov
V A
VA
Anisimova
V A
VA
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology; D010847:Picolines / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D010976:Platelet Count / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D013916:Thrombelastography
D000975:Antioxidants; D001562:Benzimidazoles; D007093:Imidazoles; C118555:N(9)-imidazo-(1,2)-benzimidazol; D010847:Picolines; D010975:Platelet Aggregation Inhibitors; D002084:Butylated Hydroxytoluene; C070020:emoxypine succinate