Identification of coumarin as the sensitizer in a patient sensitive to her own perfume but negative to the fragrance mix.
The aim of this study was to identify the chemicals responsible for the sensitivity of a 44-year-old woman to her own perfume, but showing negative patch test results to the fragrance mix. For this purpose, the perfume concentrate from the eau de toilette was chemically fractionated. Each fraction obtained was afterwards tested on the patient using a ROAT and/or a patch test. Only 1 fraction gave a positive ROAT result. This fraction was analyzed and found to contain coumarin and ethyl vanillin. Coumarin, one of the most widely used fragrance compounds that is not present in the fragrance mix, was confirmed as being the sensitizer.
Mutterer
V
V
Laboratoire de Dermatochimie, Université Louis Pasteur, Strasbourg, France.
Giménez Arnau
E
E
Lepoittevin
J P
JP
Johansen
J D
JD
Frosch
P J
PJ
Menné
T
T
Andersen
K E
KE
Bruze
M
M
Rastogi
S C
SC
White
I R
IR
D000328:Adult; D003358:Cosmetics / Q000008:administration & dosage* / Q000737:chemistry; D003374:Coumarins / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D010328:Patch Tests; D010476:Perfume / Q000009:adverse effects* / Q000737:chemistry
D003358:Cosmetics; D003374:Coumarins; D010476:Perfume; C030123:coumarin