Cytotoxic effects of NSL-1406, a new thienopyrimidine derivative, on leukocytes and osteoclasts.
We synthesized a series of thienopyrimidine derivatives and examined their cytotoxic effects on several cell lines. One of the derivatives, NSL-1406, was shown to exert potent cytotoxic effects on leukemia cell line including P388 cells and J774 cells. It was also inhibitory on mouse osteoclasts and suppressed the in vitro bone resorption by osteoclasts at nanomolar concentrations.
Katada
J
J
Life Science Research Center, Advanced Technology Research Laboratories, Nippon Steel Corporation, Kawasaki, Japan.
Iijima
K
K
Muramatsu
M
M
Takami
M
M
Yasuda
E
E
Hayashi
M
M
Hattori
M
M
Hayashi
Y
Y
D000818:Animals; D002452:Cell Count; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D020128:Inhibitory Concentration 50; D007941:Leukemia P388 / Q000188:drug therapy; D007962:Leukocytes / Q000187:drug effects*; D051379:Mice; D008956:Models, Chemical; D010010:Osteoclasts / Q000187:drug effects*; D011743:Pyrimidines / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
C119443:NSL 1406; D011743:Pyrimidines