title: Standard serum concentrations and normal fluctuations of CEA, CA 50 and CA 242 during twelve months in men and women aged 60-64 years without malignant disease.
abstract: OBJECTIVE
  To establish standard serum concentrations of carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 50 and CA 242 in cancer-free subjects in the age group during which cancers are likely to develop.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  University hospital, Sweden.
  
  
  METHODS
  Blood samples obtained by venepuncture on four occasions during one year.
  
  
  METHODS
  Consultation with the Regional Cancer Registry to exclude those who had previously had malignant disease diagnosed or developed cancer during and up to two years after the end of the clinical part of the study. Serum concentrations of CEA, CA 50, and CA 242.
  
  
  RESULTS
  The 90th centile was 5.6 ng/ml for CEA, 30.1 U/ml for CA 50, and 24.5 U/ml for CA 242. The mean (SD) serum concentrations were 2.6 ng/ml (2.2) for CEA, 13.2 U/ml (11.4) for CA 50, and 10.6 U/ml (9.6) for CA 242. Serum concentrations of CEA were significantly higher (p < 0.001) among smokers. The intraindividual fluctuations were 16%, 16%, and 14%, respectively.
  
  
  CONCLUSIONS
  Serum concentrations of CEA, CA 50, and CA 242 were higher in this study than previously reported, probably because the subjects were older than in other reports. The fluctuations were small. Serum concentrations of CEA were higher in smokers than in non-smokers.
authors: Department of Surgery, Sahlgrenska University Hospital, Göteborg, Sweden.
authors: B
authors: B
authors: Engarås
authors: L
authors: L
authors: Hafström
authors: J
authors: J
authors: Kewenter
authors: O
authors: O
authors: Nilsson
authors: H
authors: H
authors: Wedel
mesh_terms: D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood*; D002272:Carcinoembryonic Antigen / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012016:Reference Values
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; C074601:CA 242 antigen; C082699:CA-50 antigen; D002272:Carcinoembryonic Antigen