Lung air spaces: MR imaging evaluation with hyperpolarized 3He gas.
Thirty-two magnetic resonance imaging examinations of the lungs were performed in 16 subjects after inhalation of 1-2 L of helium 3 gas that was laser polarized to 10%-25%. The distribution of the gas was generally uniform, with visualization of the fissures in most cases. Ventilation defects were demonstrated in smokers and in a subject with allergies. The technique has potential for evaluating small airways disease.
de Lange
E E
EE
Department of Radiology, University of Virginia Health Sciences Center, Charlottesville 22908, USA.
Mugler
J P
JP
Brookeman
J R
JR
Knight-Scott
J
J
Truwit
J D
JD
Teates
C D
CD
Daniel
T M
TM
Bogorad
P L
PL
Cates
G D
GD
D000280:Administration, Inhalation; D000328:Adult; D000368:Aged; D001249:Asthma / Q000473:pathology; D005260:Female; D006371:Helium / Q000008:administration & dosage; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007554:Isotopes; D007834:Lasers; D008168:Lung / Q000473:pathology* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D010100:Oxygen / Q000097:blood; D011656:Pulmonary Emphysema / Q000473:pathology; D012119:Respiration; D006255:Rhinitis, Allergic, Seasonal / Q000473:pathology; D012907:Smoking / Q000473:pathology
D007554:Isotopes; D006371:Helium; D010100:Oxygen