title: Level of chronic life stress predicts clinical outcome in irritable bowel syndrome.
abstract: BACKGROUND
  Life stress contributes to symptom onset and exacerbation in the majority of patients with irritable bowel syndrome (IBS) and functional dyspepsia (FD); research evidence is conflicting, however, as to the strength of these effects.
  
  
  OBJECTIVE
  To test prospectively the relation of chronic life stress threat to subsequent symptom intensity over time.
  
  
  METHODS
  One hundred and seventeen consecutive outpatients satisfying the modified Rome criteria for IBS (66% with one or more concurrent FD syndromes) participated.
  
  
  METHODS
  The life stress and symptom intensity measures were determined from interview data collected independently at entry, and at six and 16 months; these measures assessed the potency of chronic life stress threat during the prior six months or more, and the severity and frequency of IBS and FD symptoms during the following two weeks.
  
  
  RESULTS
  Chronic life stress threat was a powerful predictor of subsequent symptom intensity, explaining 97% of the variance on this measure over 16 months. No patient exposed to even one chronic highly threatening stressor improved clinically (by 50%) over the 16 months; all patients who improved did so in the absence of such a stressor.
  
  
  CONCLUSIONS
  The level of chronic life stress threat predicts the clinical outcome in most patients with IBS/FD.
authors: Department of Gastroenterology, Royal North Shore Hospital, Sydney, Australia.
authors: E J
authors: EJ
authors: Bennett
authors: C C
authors: CC
authors: Tennant
authors: C
authors: C
authors: Piesse
authors: C A
authors: CA
authors: Badcock
authors: J E
authors: JE
authors: Kellow
mesh_terms: D000328:Adult; D017677:Age Distribution; D002908:Chronic Disease; D003109:Colonic Diseases, Functional / Q000523:psychology*; D004644:Emotions; D005260:Female; D006801:Humans; D008297:Male; D010551:Personality; D011379:Prognosis; D011446:Prospective Studies; D017678:Sex Distribution; D013315:Stress, Psychological / Q000150:complications*; D013997:Time Factors