Current status of liquid ventilation.
Perfluorochemical liquid has been used experimentally to enhance mechanical ventilation for the past 30 years. Liquid ventilation is one of the most extensively studied revolutionary medical therapies being considered for use in practice. Since 1989, when the first human neonates were treated with perfluorochemical liquid, more than 500 human patients--neonate, pediatric, and adult--have been treated with liquid ventilation as part of clinical trials. However, most of the clinically relevant information known to the medical field about liquid ventilation still comes from the laboratory. This paper seeks to briefly present current information available from studies involving liquid ventilation, both laboratory-based and clinical trials, as well as to inform the reader on patient management. In addition, we attempt to elucidate future directions.
Weis
C M
CM
University of Pennsylvania School of Medicine, Pennsylvania Hospital, Philadelphia 19104, USA.
Fox
W W
WW
D000818:Animals; D000831:Animals, Newborn; D002986:Clinical Trials as Topic; D005069:Evaluation Studies as Topic; D005466:Fluorocarbons / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000628:therapy; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000628:therapy; D012120:Respiration Disorders / Q000628:therapy; D012121:Respiration, Artificial / Q000379:methods*
D005466:Fluorocarbons; C119237:perflubronperfluorocytlbromide