The distribution of renin in the segments of the renal arterial tree in cats: an immunohistochemical and ultrastructural study.
The intrarenal distribution of renin in the cat kidney was evaluated in a semi-quantitative immunocytochemical study using a cross-reacting antiserum directed against purified renin. In addition, the morphology of the juxtaglomerular apparatus was studied electron-microscopically. The majority of renin in the cat kidney was located in the distal portion of the afferent arteriole. The values for the juxtaglomerular index and the renin-positive portion of the afferent arteriole were 30.6 +/- 3.2% and 49.9 +/- 8.3 microns, respectively. In addition, scattered renin-positive cells were found far from the vascular pole and even in the interlobular artery. Also, some vasa efferentia contained renin-positive cells. In 70% of the cats studied, renin-positive cells were located in the glomerular mesangium. The majority of the renin-positive mesangial cells were located in the vicinity of the glomerular stalk, but in some cases the centrilobular mesangium also contained renin-positive cells.
Taugner
F
F
Department of Veterinary Pathology, Freie Universität Berlin, Germany.
Krefft
G
G
D000818:Animals; D001160:Arterioles / Q000166:cytology / Q000201:enzymology*; D002415:Cats; D005260:Female; D005920:Glomerular Mesangium / Q000098:blood supply; D007606:Juxtaglomerular Apparatus / Q000201:enzymology* / Q000648:ultrastructure*; D008297:Male; D012079:Renal Circulation; D012083:Renin / Q000032:analysis*
D012083:Renin