title: The effect of tea consumption on oxidative stress in smokers and nonsmokers.
abstract: While the anticarcinogenic effects of tea in animal models have been reported by several groups, human epidemiological studies examining tea consumption and cancer prevention have produced equivocal results. The beneficial properties of tea to human health may be related to the antioxidant properties of tea components. However, little evidence has been provided that tea consumption can either increase the antioxidant capacity or decrease oxidative stress in humans. In the present study, the effects of tea treatment (green tea) on biomarkers of oxidative stress were investigated in smokers and nonsmokers in two volunteer study groups (one in China and the other in United States). Green tea consumption in both study groups decreased oxidative DNA damage (8-OHdG in white blood cells and urine), lipid peroxidation (MDA in urine), and free radical generation (2, 3-DHBA in urine) in smokers. Nonsmokers (US study group) also exhibited a decrease in overall oxidative stress.
authors: Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
authors: J E
authors: JE
authors: Klaunig
authors: Y
authors: Y
authors: Xu
authors: C
authors: C
authors: Han
authors: L M
authors: LM
authors: Kamendulis
authors: J
authors: J
authors: Chen
authors: C
authors: C
authors: Heiser
authors: M S
authors: MS
authors: Gordon
authors: E R
authors: ER
authors: Mohler
mesh_terms: D015104:3,4-Methylenedioxyamphetamine / Q000097:blood / Q000652:urine; D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D000975:Antioxidants / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine; D005260:Female; D006801:Humans; D062385:Hydroxybenzoates / Q000652:urine; D007962:Leukocytes / Q000737:chemistry; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D012907:Smoking / Q000097:blood / Q000652:urine; D013662:Tea
chemical_list: D000975:Antioxidants; D062385:Hydroxybenzoates; D010936:Plant Extracts; D013662:Tea; D015104:3,4-Methylenedioxyamphetamine; C009135:2,3-dihydroxybenzoic acid; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine