Drug-induced heart failure.
Heart failure is a clinical syndrome that is predominantly caused by cardiovascular disorders such as coronary heart disease and hypertension. However, several classes of drugs may induce heart failure in patients without concurrent cardiovascular disease or may precipitate the occurrence of heart failure in patients with preexisting left ventricular impairment. We reviewed the literature on drug-induced heart failure, using the MEDLINE database and lateral references. Successively, we discuss the potential role in the occurrence of heart failure of cytostatics, immunomodulating drugs, antidepressants, calcium channel blocking agents, nonsteroidal anti-inflammatory drugs, antiarrhythmics, beta-adrenoceptor blocking agents, anesthetics and some miscellaneous agents. Drug-induced heart failure may play a role in only a minority of the patients presenting with heart failure. Nevertheless, drug-induced heart failure should be regarded as a potentially preventable cause of heart failure, although sometimes other priorities do not offer therapeutic alternatives (e.g., anthracycline-induced cardiomyopathy). The awareness of clinicians of potential adverse effects on cardiac performance by several classes of drugs, particularly in patients with preexisting ventricular dysfunction, may contribute to timely diagnosis and prevention of drug-induced heart failure.
Feenstra
J
J
Inspectorate for Health Care, Drug Safety Unit, The Hague, The Netherlands.
Grobbee
D E
DE
Remme
W J
WJ
Stricker
B H
BH
D000276:Adjuvants, Immunologic / Q000009:adverse effects*; D000777:Anesthetics / Q000009:adverse effects*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000928:Antidepressive Agents / Q000009:adverse effects*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002317:Cardiovascular Agents / Q000009:adverse effects*; D016757:Death, Sudden, Cardiac / Q000453:epidemiology; D006333:Heart Failure / Q000139:chemically induced* / Q000175:diagnosis / Q000401:mortality; D006801:Humans; D015996:Survival Rate
D000276:Adjuvants, Immunologic; D000777:Anesthetics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000928:Antidepressive Agents; D000970:Antineoplastic Agents; D002317:Cardiovascular Agents