Effects of gender and region on proton MRS of normal human brain.
Localized, in vivo 1H magnetic resonance spectroscopy has been performed in a number of brain regions of neuropsychiatric interest in male and female control subjects to determine if gender and region affect the measured metabolite ratios. In contrast to some previous reports, no significant differences were seen in any region for any metabolite ratio between males and females. As expected, significant variations with brain region were seen for metabolite ratios for the total group of subjects.
Komoroski
R A
RA
Department of Psychiatry, University of Arkansas for Medical Sciences, Little Rock, USA. komoroskiricharda@exchange.uams.edu
Heimberg
C
C
Cardwell
D
D
Karson
C N
CN
D000328:Adult; D000368:Aged; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D001921:Brain / Q000033:anatomy & histology*; D001931:Brain Mapping; D002794:Choline / Q000378:metabolism*; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D006801:Humans; D007294:Inositol / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012737:Sex Factors
D001224:Aspartic Acid; D007294:Inositol; C000179:N-acetylaspartate; D002794:Choline