title: Effect of a single bout of acute exercise on plasma human immunodeficiency virus RNA levels.
abstract: Acute exercise is known to activate the immune system and thus could lead to increased human immunodeficiency virus (HIV) replication. We sought to determine whether a single acute bout of exercise, similar to what people experience when starting an intensive exercise program, has a detrimental effect on plasma HIV RNA levels. Twenty-five patients with HIV infection performed one 15-min bout of acute exercise. Absolute neutrophil counts, serum creatine phosphokinase, and 72-h urinary 3-methylhistidine (a marker of muscle protein breakdown) were measured before and after the exercise, along with plasma HIV RNA levels. There were increases in neutrophil counts (P < 0.06), serum creatine phosphokinase (P < 0. 01), and urinary 3-methylhistidine (P < 0.01) in response to exercise, indicating a mild acute-phase response with muscle proteolysis. However, mean HIV RNA, which was elevated at baseline in 22 of the 25 subjects (mean of 4 x 10(5) +/- 0.7 x 10(5) copies/ml), did not increase during the week after exercise (P = 0. 12). Small changes in RNA were seen in the three subjects with initially undetectable HIV RNA, but the significance of these changes is unclear. Acute exercise does not have a deleterious effect on HIV replication in adults with high viral loads. Because regular exercise training has not been shown to activate the acute-phase response, the lack of increased viral loads in response to an acute exercise intervention suggests that exercise training is safe in people with HIV infection.
authors: Department of Community Health, Department of Medicine, Tufts University School of Medicine, Boston 02111, Boston, Massachusetts 02111, USA. roubenoff@hnrc.tufts.edu
authors: R
authors: R
authors: Roubenoff
authors: P R
authors: PR
authors: Skolnik
authors: A
authors: A
authors: Shevitz
authors: L
authors: L
authors: Snydman
authors: A
authors: A
authors: Wang
authors: S
authors: S
authors: Melanson
authors: S
authors: S
authors: Gorbach
mesh_terms: D000328:Adult; D003402:Creatine Kinase / Q000097:blood; D015444:Exercise / Q000502:physiology*; D005260:Female; D006678:HIV / Q000302:isolation & purification* / Q000502:physiology; D015658:HIV Infections / Q000097:blood* / Q000503:physiopathology / Q000821:virology; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008762:Methylhistidines / Q000652:urine; D008875:Middle Aged; D009504:Neutrophils / Q000502:physiology; D005082:Physical Exertion / Q000502:physiology*; D012367:RNA, Viral / Q000097:blood*; D014779:Virus Replication
chemical_list: D008762:Methylhistidines; D012367:RNA, Viral; D003402:Creatine Kinase; C028118:3-methylhistidine