title: [New requirements in the primary treatment of arterial hypertension: why do we need fixed low-dose combination therapy?].
abstract: The latest results of studies and therapeutic trials have shown the following: Present therapeutic strategies for arterial hypertension have a certain efficacy, but appear to have reached a plateau. Arterial hypertension essentially affects older subjects who can benefit from the advantages of antihypertensive treatment as much as, if not more than, younger subjects. A better evaluation of the cardiovascular risk of the patient is essential: This should include all the components of arterial hypertension (diastolic and systolic blood pressures and pulse pressure), risk factors, associated pathologies, and target-organ damage. Such an evaluation will help fix therapeutic objectives tailored to individual patientsí needs. The limitations of monotherapy in achieving this objective: They are demonstrated in clinical practise, as well as in large-scale trials. In this context, new strategies based on the first-line use of fixed very-low-dose combination therapies appear to be both useful and promising, as well as being in line with the latest recommendations.
authors: CHU La Timone, Marseille.
authors: B
authors: B
authors: Vaïsse
authors: F
authors: F
authors: Silhol
authors: K
authors: K
authors: Bouchlagen
authors: H
authors: H
authors: Gallois
authors: L
authors: L
authors: Poggi
mesh_terms: D000959:Antihypertensive Agents / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*
chemical_list: D000959:Antihypertensive Agents