title: Functional impairment in instrumental activities of daily living: an early clinical sign of dementia?
abstract: OBJECTIVE
  To estimate the predictive value of four IADLs on 3- and 5-year incident dementia.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  A community survey in 37 randomly selected parishes.
  
  
  METHODS
  A random sample of French community dwellers aged 65 and older included in the PAQUID study followed-up at 3 (1582 subjects) and 5 years (1283 subjects).
  
  
  METHODS
  Incidence of dementia at 3 and 5 years, diagnosed by two-step screening: (1) MMS and DSM-III-R; (2) diagnosis of dementia confirmed by a neurologist.
  
  
  RESULTS
  A score summing up the number of dependencies at baseline on four IADLs is a predictor of 3-year but not of 5-year incident dementia. Increase in the level of dependence between baseline and 3-year follow-up is associated with an increased risk of incident dementia at 5-year follow-up.
  
  
  CONCLUSIONS
  These four IADLs can help to identify older subjects at high risk of dementia who should then undergo neuropsychological testing.
authors: INSERM U330, Université Victor Segalen Bordeaux2, France.
authors: P
authors: P
authors: Barberger-Gateau
authors: C
authors: C
authors: Fabrigoule
authors: C
authors: C
authors: Helmer
authors: I
authors: I
authors: Rouch
authors: J F
authors: JF
authors: Dartigues
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D003704:Dementia / Q000209:etiology*; D015577:Geriatric Assessment; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008403:Mass Screening; D008609:Mental Status Schedule; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D011446:Prospective Studies; D015203:Reproducibility of Results; D012307:Risk Factors; D011795:Surveys and Questionnaires