Update on sequential isologous rat organ transplantation: pancreaticoduodenal and kidney transplantations.
This periodic report includes intermittent results of consecutive pancreaticoduodenal (Pd) and kidney (Kt) transplants in inbred rats and results on double kidney transplants that did not follow sequential transplant protocol. Eight 24-month-old Lewis pancreas, kidney, and aorta served histological controls showing normal histological architecture with no atherosclerosis developed in the aorta. Thirty-four month old pancreas and thirty-two month old kidneys, which resided in young hosts for at least three occasions, appeared as youthful Pd and Kt grafts. They show normal histological appearance for more than the expected life span of a Lewis rat. The fact that not only pancreases but also kidneys outlived their host leads to the study of other different organs' viability as aged valuable grafts. Nevertheless, the threats by the development of atherosclerosis in graft-associated aortas resulted in slow progression of the follow-ups.
Lee
S
S
San Diego Microsurgical Institute, Mercy Hospital Medical Center, California 92103, USA.
Wang
Y
Y
Mao
L
L
Cho
C
C
Kim
S
S
Tarin
T
T
Kim
D H
DH
Mazzoni
G
G
Fazi
M
M
Nozawa
M
M
Lee
D
D
Sileshi
B
B
Wei
W
W
Lentini
A
A
Yoo
C H
CH
Youngkin
T
T
Wolf
P
P
D'Silva
M
M
Gittes
R F
RF
D000818:Animals; D013505:Digestive System Surgical Procedures / Q000379:methods / Q000401:mortality; D004386:Duodenum / Q000473:pathology / Q000637:transplantation*; D005260:Female; D007668:Kidney / Q000473:pathology; D016030:Kidney Transplantation / Q000379:methods / Q000401:mortality / Q000473:pathology; D008297:Male; D008866:Microsurgery / Q000379:methods; D010179:Pancreas / Q000473:pathology; D016035:Pancreas Transplantation / Q000379:methods / Q000401:mortality / Q000473:pathology; D051381:Rats; D011917:Rats, Inbred Lew; D013997:Time Factors; D014185:Transplantation, Isogeneic