title: Clinicopathological features of superficial depressed-type colorectal neoplastic lesions.
abstract: OBJECTIVE
  We performed this study to analyze the endoscopic findings, dissecting microscopic features, and p53 immunostaining in superficial depressed-type (depressed) colorectal neoplastic lesions.
  
  
  METHODS
  Dissecting stereomicroscopy was used to ascertain the size and pit pattern of lesions removed by endoscopic snare polypectomy. Immunohistochemical staining of p53 was performed with an antigen retrieval system using a monoclonal antibody to p53.
  
  
  RESULTS
  All depressed neoplastic lesions (submucosal carcinoma, n = 6; high-grade dysplasia, n = 14; and adenoma, n = 30) were small (< 1 cm in diameter) and were detected as a depression with or without a marginal elevation on colonoscopic examination. In the dissecting microscopic study, submucosal carcinomas and lesions of high-grade dysplasia almost exclusively showed irregular small pits, with the exception of four malignant lesions with moderate submucosal invasion in which the pit structure was absent. In contrast, adenomas had either regular small (29/30 lesions) or oval pits (1/30 lesions). Rates of p53 positivity were 100%, 64%, and 7% in depressed submucosal carcinomas, lesions of high-grade dysplasia, and adenomas, respectively, thus the prevalence of p53 positivity was significantly higher in the former two groups than in the adenoma group.
  
  
  CONCLUSIONS
  The high frequency of invasive carcinoma and high-grade dysplasia found in depressed colorectal neoplastic tumors, despite their small size, indicates that these lesions may be a subtype of colorectal tumor with more aggressive malignant potential at an earlier stage.
authors: Department of Gastroenterology, Meitetsu Hospital, Nagoya, Japan.
authors: M
authors: M
authors: Hayakawa
authors: K
authors: K
authors: Shimokawa
authors: K
authors: K
authors: Kusugami
authors: M
authors: M
authors: Sugihara
authors: Y
authors: Y
authors: Morooka
authors: T
authors: T
authors: Fujita
authors: M
authors: M
authors: Nakamura
authors: Y
authors: Y
authors: Nishio
authors: K
authors: K
authors: Maeda
authors: T
authors: T
authors: Ando
authors: R M
authors: RM
authors: Peek
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000473:pathology; D002277:Carcinoma / Q000175:diagnosis / Q000473:pathology; D003106:Colon / Q000473:pathology; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D012007:Rectum / Q000473:pathology; D012189:Retrospective Studies; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
chemical_list: D016159:Tumor Suppressor Protein p53