Aldosterone directly induces Na, K-ATPase alpha 1-subunit mRNA in the renal cortex of rat.
The change of blood pressure and the induction of Na, K-ATPase alpha 1-subunit mRNA have been investigated in the renal cortex of aldosterone-treated hypertensive rat. The increase of blood pressure by aldosterone-treatment for 25 days was decreased by the treatment of amiloride or spironolactone. The level of Na, K-ATPase alpha 1-subunit mRNA of the renal cortex in aldosterone-treated rat was increased than that in the control, and its increase was repressed by treatment of spironolactone, but not altered by the treatment of amiloride. This result suggests that the increase of Na, K-ATPase alpha 1-subunit mRNA in the renal cortex of aldosterone-treated hypertensive rat may be related with the direct induction of Na, K-ATPase mRNA without the increase of Na-traffic through Na-channel.
Seok
J H
JH
Department of Pharmacology, College of Medicine, Chungnam National University, Taejon, Korea.
Hong
J H
JH
Jeon
J R
JR
Hur
G M
GM
Sung
J Y
JY
Lee
J H
JH
D000450:Aldosterone / Q000494:pharmacology*; D000584:Amiloride / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D006973:Hypertension / Q000139:chemically induced*; D007668:Kidney / Q000187:drug effects*; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D015222:Sodium Channels / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000737:chemistry / Q000235:genetics*; D013148:Spironolactone / Q000494:pharmacology; D013997:Time Factors
D012333:RNA, Messenger; D015222:Sodium Channels; D013148:Spironolactone; D000450:Aldosterone; D000584:Amiloride; D000254:Sodium-Potassium-Exchanging ATPase