HIV: The deadly passenger in dendritic cells.
A picture is emerging of how HIV subverts a normal immunological surveillance mechanism to establish primary infection. This involves the infection of dendritic cells at mucosal surfaces: as these cells then mature, they transport the virus to lymphoid tissue, where viral replication begins and infection of CD4(+) T cells occurs.
Rowland-Jones
S L
SL
Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK.
D003713:Dendritic Cells / Q000821:virology; D006678:HIV; D015658:HIV Infections / Q000635:transmission / Q000821:virology*; D006801:Humans