Influence of stimulation of the olivocerebellar pathway by harmaline on spatial learning in the rat.
Administration of harmaline to the rat, which activates synchronously and rhythmically the olivary neurons and the olivocerebellar pathway, elicits visuo-motor, spatial learning and spatial memory deficiencies which are dose-dependent. Since activation and lesion of the olivocerebellar pathway have similar effects, it is concluded that normal functioning of this pathway is required for spatial learning achievement.
Meignin
C
C
UPRES PSY.CO 1780, Faculté des Sciences, Laboratoire de Neurobiologie de l'Apprentissage, Université de Rouen, 76821 Mont-Saint-Aignan Cedex, France.
Hilber
P
P
Caston
J
J
D000704:Analysis of Variance; D000818:Animals; D002531:Cerebellum / Q000187:drug effects*; D003463:Cues; D006246:Harmaline / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D008568:Memory / Q000187:drug effects*; D011939:Mental Recall / Q000187:drug effects; D009434:Neural Pathways / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D009847:Olivary Nucleus / Q000166:cytology / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical
D006246:Harmaline