[Use of neoton and finoptin to correct metabolic disorders of the brain in craniocerebral injuries].
Experiments on 55 outbred adult white rats narcotized with calipsol (50 mg/kg intraperitoneally) showed that separate infusions of a synthetic creatine phosphate analog neoton (100 mg/kg) and calcium antagonist finoptin (0.1 mg/kg) into the carotid artery directly after infliction of dosed craniocerebral injury improve energy metabolism and limit the intensity of lipid peroxidation in the brain during the first hour of the posttraumatic period.
Dolgikh
V T
VT
Zakharov
I V
IV
Ivanov
S R
SR
D000818:Animals; D001921:Brain / Q000378:metabolism*; D001930:Brain Injuries / Q000188:drug therapy / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000627:therapeutic use*; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002339:Carotid Arteries; D004734:Energy Metabolism; D006801:Humans; D007261:Infusions, Intra-Arterial; D015227:Lipid Peroxidation; D010725:Phosphocreatine / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D013997:Time Factors; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D014700:Verapamil / Q000008:administration & dosage / Q000627:therapeutic use*
D002121:Calcium Channel Blockers; D002316:Cardiotonic Agents; D014665:Vasodilator Agents; D010725:Phosphocreatine; D014700:Verapamil