[The effect of phenazepam on the pancreatic excretory function in thermal stress].
The excretory function of the pancreas was studied on albino rats during thermal stress and ACTH (corticotropine) administration. Stress inhibited the enzyme-synthesizing and enzyme-secreting functions of the gland. The tranquilizer phenazepam influencing the GABA-ergic brain systems exerted a protective effect on pancreatic exosecretion in stress and its strength depended on the administration regimen of the drug. Experiments with corticotropine have shown that the antistress effect of phenazepam, to a certain extent is related to its action on the level of ACTH production in the hypophysis.
Zakirov
E U
EU
Department of Pathological Physiology, 2nd Tashkent Medical Institute, Uzbekistan Republic.
Karimov
Kh Ia
KhIa
Rianskaia
O M
OM
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001569:Benzodiazepines; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D018882:Heat Stress Disorders / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D008297:Male; D010179:Pancreas / Q000187:drug effects* / Q000503:physiopathology; D051381:Rats; D018079:Receptors, GABA / Q000187:drug effects / Q000502:physiology; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D013997:Time Factors
D014151:Anti-Anxiety Agents; D018079:Receptors, GABA; D001569:Benzodiazepines; C017928:phenazepam; D000324:Adrenocorticotropic Hormone