Multiple positive and negative regulators of signaling by the EGF-receptor.
Signaling via the epidermal growth factor (EGF)-receptor family is subject to regulation and modulation by multiple ligands, effectors and negative regulators, as well as regulation by heterodimerization between family members and crosstalk between heterologous signaling pathways. Besides serving as a paradigm for receptor tyrosine kinases in general, this family is crucial for development and is often mutated or amplified in human tumors.
Moghal
N
N
Howard Hughes Medical Institute, Division of Biology, 156-29 Caltech, 391 South Holliston Avenue, Pasadena, CA 91125, USA.
Sternberg
P W
PW
D000818:Animals; D001692:Biological Transport; D017173:Caenorhabditis elegans / Q000378:metabolism; D029742:Caenorhabditis elegans Proteins; D015815:Cell Adhesion Molecules / Q000502:physiology; D002462:Cell Membrane / Q000378:metabolism; D019281:Dimerization; D004815:Epidermal Growth Factor / Q000502:physiology*; D066246:ErbB Receptors / Q000737:chemistry / Q000502:physiology*; D005246:Feedback; D015801:Helminth Proteins / Q000502:physiology; D006801:Humans; D008024:Ligands; D008954:Models, Biological; D009363:Neoplasm Proteins / Q000502:physiology; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology; D010766:Phosphorylation; D055503:Protein Multimerization; D011499:Protein Processing, Post-Translational; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
D029742:Caenorhabditis elegans Proteins; D015815:Cell Adhesion Molecules; D015801:Helminth Proteins; D008024:Ligands; D009363:Neoplasm Proteins; D004815:Epidermal Growth Factor; D019869:Phosphatidylinositol 3-Kinases; D066246:ErbB Receptors; C085873:let-23 protein, C elegans; D017027:Protein Tyrosine Phosphatases