[Effect of gentamycin on persistence of tick-borne encephalitis].
Effect of gentamicin, an aminoglycoside antibiotic, on the persistence of tick-borne encephalitis (TBE) virus in Syrian hamsters and Macaca iris in remote periods (70-434 days) after inoculation is studied. Attempts at virus isolation from animals treated with gentamicin failed. Unlike other aminoglycosides, e.g. streptomycin, gentamicin exerted no immunodepressive effect; moreover, immunocorrection was observed in some experiments on monkeys and hamsters. None of the 10 previously tested antibiotics elicited such an effect or inhibited the persisting TBE virus. Morphological study of the central nervous system in hamsters and monkeys showed that injection of gentamicin did not cause an exacerbation of chronic encephalitis. The mechanism of immunocorrecting effect of gentamicin is to be further investigated.
Pogodina
V V
VV
Malenko
G V
GV
Karmysheva
V Ia
VIa
Frolova
M P
MP
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002490:Central Nervous System / Q000473:pathology; D006224:Cricetinae; D004669:Encephalitis Viruses, Tick-Borne / Q000187:drug effects / Q000302:isolation & purification*; D004675:Encephalitis, Tick-Borne / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D005839:Gentamicins / Q000494:pharmacology / Q000627:therapeutic use*; D008251:Macaca; D008647:Mesocricetus
D000900:Anti-Bacterial Agents; D005839:Gentamicins