title: Detection of autonomic sympathetic dysfunction in diabetic patients. A study using laser Doppler imaging.
abstract: OBJECTIVE
  To study signs of the disturbed reflex autonomic sympathetic nerve function in type 1 and type 2 diabetic patients.
  
  
  METHODS
  Measurements were made on 15 type 1 (duration 13-32 years) and on 50 recently diagnosed type 2 diabetic patients (duration 3-4 years). The vasoconstrictor responses in the distal phalanx of the middle finger (locally heated to 40 degrees C) to the cooling of the contralateral arm were measured using Laser Doppler Imaging (LDI). A vasoconstriction index (VAC) was calculated taking age into account and was compared with reference values obtained in 80 control subjects. The diabetic patients were also studied with deep-breathing tests (i.e., the heart-rate variation expressed as the expiration-to-inspiration [E/I] ratio, a test of parasympathetic nerve function).
  
  
  RESULTS
  The vasoconstrictor responses to indirect cooling (VAC) were significantly reduced in the fingers of the diabetic patients, both type 2 (0.77 +/- 0.02 V; P < 0.01) and type 1 (0.83 +/- 0.04 V; P < 0.001), compared with the healthy control subjects (0.65 +/- 0.01); the age-corrected VAC (VACz) was slightly more impaired in type 1 than in type 2 diabetic patients. The frequency of an abnormal VACz corresponded well to the frequency of an abnormal E/I ratio in type 1 diabetic patients (approximately 50%), whereas the frequency of an abnormal VACz was significantly higher than an abnormal E/I ratio among type 2 diabetic patients (11/50 vs. 4/50; P < 0.05).
  
  
  CONCLUSIONS
  Both type 1 and type 2 diabetic patients have impaired cutaneous blood flow regulation. The VAC index seems to be a promising tool for detection of subclinical changes in autonomic sympathetic function.
authors: Department of Clinical Physiology, Malmo University Hospital, Sweden. siv.bornmyr@klinfys.mas.lu.se
authors: S
authors: S
authors: Bornmyr
authors: J
authors: J
authors: Castenfors
authors: H
authors: H
authors: Svensson
authors: M
authors: M
authors: Wroblewski
authors: G
authors: G
authors: Sundkvist
authors: P
authors: P
authors: Wollmer
mesh_terms: D000293:Adolescent; D000328:Adult; D001341:Autonomic Nervous System / Q000000981:diagnostic imaging* / Q000503:physiopathology; D003080:Cold Temperature; D003922:Diabetes Mellitus, Type 1 / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005260:Female; D006339:Heart Rate; D006801:Humans; D017078:Laser-Doppler Flowmetry; D008297:Male; D012039:Regional Blood Flow; D012867:Skin / Q000098:blood supply; D014463:Ultrasonography; D014661:Vasoconstriction