title: [Study of NAIP gene in spinal muscular atrophy].
abstract: OBJECTIVE
  Investigating the correlation between the genotype and spinal muscular atrophy(SMA) clinical phenotype.
  
  
  METHODS
  Neuronal apoptosis inhibitory protein(NAIP) gene analysis was performed by PCR amplification of exon 5 in 13 unrelated SMA patients with deletions of SMN gene.
  
  
  RESULTS
  Two Type-I patients(2 M5, 40%) lacked the NAIP exon 5.
  
  
  CONCLUSIONS
  The results suggest a possible correlation between NAIP gene deletion and the disease severity of SMA.
authors: The Second Hospital, China Medical University, Shenyang, 110003, P. R. China. cmu2hosp@iris.cmu.edu.cn
authors: H
authors: H
authors: Ma
authors: Y
authors: Y
authors: Wang
authors: Z
authors: Z
authors: Mi
authors: Y
authors: Y
authors: Wu
authors: P
authors: P
authors: Zhao
authors: S
authors: S
authors: Zhao
authors: M
authors: M
authors: Jiang
authors: Y
authors: Y
authors: Li
mesh_terms: D002648:Child; D017353:Gene Deletion; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics*; D051616:Neuronal Apoptosis-Inhibitory Protein; D016133:Polymerase Chain Reaction; D014897:Spinal Muscular Atrophies of Childhood / Q000235:genetics*
chemical_list: C496800:NAIP protein, human; D009419:Nerve Tissue Proteins; D051616:Neuronal Apoptosis-Inhibitory Protein