[Changes in the oxygen-binding properties of the blood in white rats under the influence of hypoxia and its pharmacological correction].
It was shown that acute (7% of oxygen in nitrogen, 30-60 min) and chronic hypoxic hypoxia (adaptation to the conditions of the middle mountains 2100 m above sea level) increased hemoglobin contents and organic phosphates--2,3-DPG and ATP in Wistar rats. Preliminary administration of taurine, taurile, ionole in normal and hypoxic conditions had no essential effect on the oxygen blood capacity where as the content of 2,3-DPG and glucoso-6-phosphate dehydrogenase activity increased. Taurin was more effective, than tauril.
Dudariev
V P
VP
Kiev Research Institute of Haematology and Blood Transfusion.
Lanovenko
I I
II
D000208:Acute Disease; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D002084:Butylated Hydroxytoluene / Q000627:therapeutic use; D002908:Chronic Disease; D004353:Drug Evaluation, Preclinical; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D006454:Hemoglobins / Q000032:analysis / Q000187:drug effects; D000860:Hypoxia / Q000097:blood* / Q000188:drug therapy*; D008297:Male; D010100:Oxygen / Q000097:blood*; D051381:Rats; D017208:Rats, Wistar; D013654:Taurine / Q000627:therapeutic use
D000975:Antioxidants; D006454:Hemoglobins; D013654:Taurine; D002084:Butylated Hydroxytoluene; D010100:Oxygen