title: Stimulation of interleukin-1 and -6 production in alveolar macrophages by the neotropical liana, Uncaria tomentosa (uña de gato)
abstract: Two extracts of different collections of the traditional medicine uña de gato (Uncaria tomentosa) from Peru were characterized by High Pressure Liquid Chromatography as containing approximately 6 mg/g total oxindole content prior to studies with alveolar macrophages. The plant preparations greatly stimulated IL-1 and IL-6 production by rat macrophages in a dose dependent manner in the range of 0.025-0.1 mg/ml. They were also able to enhance IL-1 and -6 in lipopolysaccharide-stimulated macrophages. The results suggest a strong immunostimulant action of this plant.
authors: Department of Cellular and Molecular Medicine, University of Ottawa, Ont., Canada.
authors: I
authors: I
authors: Lemaire
authors: V
authors: V
authors: Assinewe
authors: P
authors: P
authors: Cano
authors: D V
authors: DV
authors: Awang
authors: J T
authors: JT
authors: Arnason
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D007375:Interleukin-1 / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism*; D016676:Macrophages, Alveolar / Q000187:drug effects* / Q000378:metabolism; D010568:Peru; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D051381:Rats; D019666:Rubiaceae / Q000737:chemistry*
chemical_list: D007375:Interleukin-1; D015850:Interleukin-6; D010936:Plant Extracts