Association study of the 5-HT6 receptor gene in schizophrenia.
Serotonergic (5-hydroxytryptamine; 5-HT) transmission may play an important role in the treatment and/or pathogenesis of schizophrenia. Previous studies reported that several atypical antipsychotic agents have high affinities for the 5-HT6 receptor. The 5-HT6 receptor gene polymorphism might contribute to the genetic background of this disorder. One hundred and fifty unrelated patients with schizophrenia and 150 unrelated healthy controls were genotyped for a biallelic polymorphism (267C/T) at the 5-HT6 receptor gene. No significant positive association between the 5-HT6 receptor genotype and schizophrenia was observed. Our results suggests that the 267C/T polymorphism of the 5-HT6 receptor gene may not be involved in the susceptibility to schizophrenia.
Shinkai
T
T
Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan. shinkai@med.uoeh-u.ac.jp
Ohmori
O
O
Kojima
H
H
Terao
T
T
Suzuki
T
T
Abe
K
K
D000328:Adult; D000368:Aged; D000483:Alleles; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D011985:Receptors, Serotonin / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
D011985:Receptors, Serotonin