Molecular mechanisms of the copper dependent oxidation of low-density lipoprotein.
There is little doubt that oxidative modification of low-density lipoprotein (LDL) is an important process during atherogenesis. This conclusion has been derived in a relatively short period of time since the initial descriptions of LDL oxidation with a significant contribution from Professor Esterbauer and colleagues. In this short overview, we have described the mechanisms by which copper promotes LDL oxidation focussing on the importance of lipid hydroperoxides in this process. These mechanisms are discussed in the context of the ongoing debate as to relevance of metal dependent LDL oxidation in vivo and as a model reaction for assessing antioxidants.
Patel
R P
RP
Center for Free Radical Biology, Department of Pathology, University of Alabama at Birmingham, 35294-0019, USA.
Darley-Usmar
V M
VM
D000975:Antioxidants / Q000378:metabolism; D001161:Arteriosclerosis / Q000209:etiology / Q000378:metabolism; D003300:Copper / Q000378:metabolism*; D006801:Humans; D008054:Lipid Peroxides / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000378:metabolism*; D010084:Oxidation-Reduction
D000975:Antioxidants; D008054:Lipid Peroxides; D008077:Lipoproteins, LDL; D003300:Copper