[The blood-simulating properties of a recombinant colony-stimulating factor and glycyram during cytostatic myelosuppression].
The hemostimulating activity of the drug glycyrram and the recombinant granulocytic-macrophagic colony-stimulating factor (CSF) was compared on models of myelosuppression induced by injection of an alkylating agent cyclophospane (CF) or the antimetabolite 5-fluorouracil (5-FU). It was found that glycerram stimulated hematopoiesis more effectively after 5-FU injection but to a lesser extent (in relation to CSF) in CF injection.
Dygaĭ
A M
AM
Institute of Pharmacology, Tomsk Research Center, Russian Academy of Medical Sciences, Russia.
Zhdanov
V V
VV
Masycheva
V I
VI
Minakova
M Iu
MIu
Romanov
V P
VP
Pustoshilova
N M
NM
Simanina
E V
EV
Agafonov
V I
VI
Gol'dberg
E D
ED
D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology*; D018906:Antineoplastic Agents, Alkylating / Q000494:pharmacology; D001853:Bone Marrow / Q000187:drug effects*; D003114:Colony-Forming Units Assay / Q000706:statistics & numerical data; D003520:Cyclophosphamide / Q000494:pharmacology; D003864:Depression, Chemical; D005472:Fluorouracil / Q000494:pharmacology; D006034:Glycyrrhetinic Acid / Q000494:pharmacology*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology*; D006410:Hematopoiesis / Q000187:drug effects*; D051379:Mice; D008808:Mice, Inbred CBA; D011994:Recombinant Proteins; D013268:Stimulation, Chemical; D013997:Time Factors
D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D018906:Antineoplastic Agents, Alkylating; D011994:Recombinant Proteins; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D003520:Cyclophosphamide; D006034:Glycyrrhetinic Acid; D005472:Fluorouracil