Correlation of fasting serum C-peptide and insulin with markers of metabolic syndrome-X in a homogenous Chinese population with normal glucose tolerance.
We surveyed 1447 men and 1800 women aged 30 years (mean 46.7 years) with normal glucose tolerance in Kin-Chen, Kinmen. Correlations of fasting serum insulin and C-peptide with various clinical and biochemical parameters were analyzed by multiple linear regression analysis. Women had significantly higher levels of insulin than men (98+/-43 vs. 91+/-43 pM, p<0.0001), yet they also had a more favorable cardiovascular risk profile. Insulin was positively associated with the female sex, height, body mass index, waist-to-hip ratio, serum triglyceride, total cholesterol, uric acid, and fasting plasma glucose, and was negatively associated with age, smoking, and high-density lipoprotein cholesterol. Independent correlates for C-peptide were similar to those of insulin, except for the addition of mean blood pressure and the exclusion of age and total cholesterol. Significant interaction of sex-body mass index (coefficient = -0.0051, p = 0.0232) was detected for C-peptide only. In conclusion, both fasting serum insulin and C-peptide are quantitatively associated with cardiovascular risk factors in this homogeneous Chinese population with normal glucose tolerance. The female sex is independently associated with higher insulin and C-peptide levels, and the strength of the positive association between the female sex and C-peptide reduces when the body mass index increases.
Chen
C H
CH
Department of Social Medicine, National Yang-Ming University, Veterans General Hospital-Taipei, Taipei, Taiwan. chench@vghtpe.gov.tw
Tsai
S T
ST
Chou
P
P
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D002096:C-Peptide / Q000097:blood*; D002681:China / Q000208:ethnology; D005215:Fasting / Q000097:blood*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D008297:Male; D017566:Microvascular Angina / Q000097:blood* / Q000208:ethnology; D008875:Middle Aged; D012189:Retrospective Studies; D012727:Sex Characteristics; D011795:Surveys and Questionnaires
D015415:Biomarkers; D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin