The effects of the initial lung deposit on uranium biokinetics after administration as UF4 and UO4.
This study was designed to assess the effect of the initial lung deposit (ILD) on uranium biokinetics in rats after intracheal instillation of biologically soluble uranium compounds. Rats received various doses of either UO4 or UF4 dust. The uranium content was determined in the kidneys, lungs, remaining carcass, urine and faeces at intervals of up to 30 days. The percentages of uranium absorbed into blood, transferred to tissues, and excreted in urine were independent of the uranium lung deposit for the two compounds. The K/K + U ratio 24 h after installation (K is the per cent of uranium retained in the kidneys and U the per cent excreted in urine) which can be used to evaluate kidney function, was essentially constant in the range from 0.02 to 12.5 microg U g(-1) kidneys.
Houpert
P
P
Institut de Protection et de Sûreté Nucléaire, Département de Protection de la santé de l'Homme et de Dosimétrie, Pierrelatte, France.
Chazel
V
V
Paquet
F
F
Henge-Napoli
M H
MH
Ansoborlo
E
E
D000818:Animals; D004305:Dose-Response Relationship, Drug; D008168:Lung / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D015203:Reproducibility of Results; D014018:Tissue Distribution; D014501:Uranium / Q000493:pharmacokinetics* / Q000652:urine; D017974:Uranium Compounds / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000652:urine
D017974:Uranium Compounds; C114698:uranium peroxide; D014501:Uranium; C045394:uranium tetrafluoride