[Improvement of the selective perception and learning with the analog of C-terminal fragment of vasopressin in rats].
New analogue of the AVP(6-9), the D-MPRG was administered intranasally in different doses. The administration improved the process of conditioning. The most efficient dose turned out to be 0/01 mcg/kg. Tetrapeptide administered 1 hour before each learning session and immediately after it accelerated the avoidance conditioning. The peptide effect was more obvious in conditioning with a negative reinforcement. The data obtained suggest that the D-MPRG mostly affects the perception of experimental environment as well as improves the consolidation of memory traces. The peptide was also shown to delay extinction of previously learned skills.
Ponomareva
N S
NS
Moscow State University, Russia.
Voskresenskaia
O G
OG
Kanenskiĭ
A A
AA
Golubovich
V P
VP
Ashmarin
I P
IP
D000281:Administration, Intranasal; D000818:Animals; D001127:Arginine Vasopressin / Q000008:administration & dosage / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D007858:Learning / Q000187:drug effects* / Q000502:physiology; D008568:Memory / Q000187:drug effects / Q000502:physiology; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
D010446:Peptide Fragments; C112795:acetylmethionyl-prolyl-arginyl-glycinamide; D001127:Arginine Vasopressin