title: Gross pathologic types of hepatocellular carcinoma in Italy.
abstract: The prevalence and independent predictors of the different macroscopic types of hepatocellular carcinoma (HCC) were assessed in 1,073 unselected patients of 14 hospitals in Italy from May 1996 to May 1997. Solitary HCC was the most common cancer type (44.6%), followed by multinodular (44.2%), diffuse (8.4%) and massive (2.8%) types. After adjustment for the influence of confounders by multiple logistic regression analysis, Child-Pugh grades B and C were found to be independent predictors of multinodular (odds ratio, OR, 2.0; 95% confidence interval (CI) = 1.5-2.6) and diffuse (OR 2.6; 95% CI = 1.6-4.4) HCC types. These findings indicate that the majority of HCC cases are not detected at a potentially treatable stage. Delayed detection of HCC is associated with a higher likelihood of the multinodular or diffuse gross pathologic type.
authors: Laboratorio di Epidemiologia, ISS, Roma, Rome, Italy.
authors: T
authors: T
authors: Stroffolini
authors: P
authors: P
authors: Andreone
authors: A
authors: A
authors: Andriulli
authors: A
authors: A
authors: Ascione
authors: A
authors: A
authors: Craxì
authors: M
authors: M
authors: Chiaramonte
authors: D
authors: D
authors: Galante
authors: O G
authors: OG
authors: Manghisi
authors: R
authors: R
authors: Mazzanti
authors: C
authors: C
authors: Medaglia
authors: G
authors: G
authors: Pilleri
authors: G L
authors: GL
authors: Rapaccini
authors: M
authors: M
authors: Albanese
authors: G
authors: G
authors: Taliani
authors: M E
authors: ME
authors: Tosti
authors: E
authors: E
authors: Villa
authors: G
authors: G
authors: Gasbarrini
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000453:epidemiology / Q000473:pathology* / Q000821:virology; D005260:Female; D006508:Hepatitis Antibodies / Q000097:blood; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008113:Liver Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000821:virology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015995:Prevalence
chemical_list: D006508:Hepatitis Antibodies