Influenza virus overcomes apoptosis by rapid multiplication.
The kinetics of apoptotic fragmentation of the chromosomal DNA was determined in the influenza virus-infected MDCK, HeLa and KB cells, respectively. Comparison of these kinetics with the kinetics of virus multiplication revealed that the multiplication of influenza virus was observed only when apoptosis was induced after the production of progeny virus in the infected cells. The extent of apoptotic response was reversely correlated with the permissiveness of the cells.
Kurokawa
M
M
Department of Nursing, School of Medical Sciences, The University of Tokushima, Tokushima 770-8503, Japan.
Koyama
A H
AH
Yasuoka
S
S
Adachi
A
A
D000818:Animals; D017209:Apoptosis; D002460:Cell Line; D053938:DNA Fragmentation; D004285:Dogs; D006801:Humans; D009980:Influenza A virus / Q000472:pathogenicity* / Q000502:physiology*; D007700:Kinetics; D014774:Virulence; D014779:Virus Replication