[Vaccination against type 1 diabetes at the clinical trial stage].
The occurrence of type I diabetes is associated with autoimmunity against insulin, glutamate decarboxylase (GAD65) and the transmembrane protein IA-2. Experiments in the spontaneously diabetic NOD mouse and the BB rat have shown early autoantigen treatment to confer protection from diabetes. The question remains of whether human type I diabetes can be prevented by autoantigen 'vaccination'.
Lernmark
A
A
University of Washington, Seattle, USA. ake@u.washington.edu
D000818:Animals; D001324:Autoantigens / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology / Q000517:prevention & control*; D006801:Humans; D051379:Mice; D051381:Rats; D012106:Research
D001324:Autoantigens