Twenty-four hour ambulatory nasal pH monitoring.
The nasal delivery of drugs, both for systemic and local use, is an expanding field with many drugs being delivered by this route. It is known that changes in pH can affect drug absorption but there is no data regarding intranasal pH over time. We present the results of 24-h ambulatory nasal pH monitoring in four subjects, each of whom had monitoring on two separate occasions. The apparatus consisted of a pH monitor with two electrodes, thus enabling us to take readings from 1 and 4 cm behind the anterior end of the inferior turbinate. Measurements were recorded every 6 s by the posterior electrode and every 30 s by the anterior electrode. The recording apparatus was worn around the subjects waist. Analysis of the results showed that there was no diurnal variation and no significant differences between the subjects. The mean pH from the anterior electrode was higher than that from the posterior (7.1 versus 6.6). The pH did not fluctuate with daily activities such as eating, drinking or sleeping. The results are interesting and may be of importance with regard to the design of formulations for nasal drug delivery systems.
Hehar
S S
SS
Department of Otorhinolaryngology/Head and Neck Surgery, University Hospital, Nottingham, UK.
Mason
J D
JD
Stephen
A B
AB
Washington
N
N
Jones
N S
NS
Jackson
S J
SJ
Bush
D
D
D000203:Activities of Daily Living; D000281:Administration, Intranasal; D000328:Adult; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D018670:Monitoring, Ambulatory; D009296:Nasal Cavity; D009297:Nasal Mucosa / Q000378:metabolism*