Antimalarial activity of 3-hydroxyalkyl-2-methylene-propionic acid derivatives.
Several Baylis-Hillman adducts and their derivatives were synthesized and evaluated as targeted potential anti-malarials. The compounds 4, 7 and 9 were found to have highest potency against P. falciparum in vitro. The in vivo test result of compound 4 and 9 against P. berghei demonstrated activity at 80 mg/Kg dose level.
Kundu
M K
MK
Department of Chemistry, Indian Institute of Technology, Powai, Bombay.
Kundu
M K
MK
Sundar
N
N
Kumar
S K
SK
Bhat
S V
SV
Biswas
S
S
Valecha
N
N
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004351:Drug Resistance; D010962:Plasmodium berghei / Q000187:drug effects*; D010963:Plasmodium falciparum / Q000187:drug effects*; D011422:Propionates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
D000962:Antimalarials; D011422:Propionates; D002738:Chloroquine