Interaction between Ukrain and Naltrexone in the writhing syndrome test in mice.
The interaction between Ukrain and Naltrexone, a nonselective opioid receptor antagonist, was studied in the 'writhing syndrome' test in mice. Naltrexone (1 mg/kg s.c.) was administered i.p. 30 min before Ukrain (2.375, 4.75, 9.5 and 19 mg/kg). In addition, the antinociceptive properties of Ukrain and Naltrexone in 10-day treatment in mice were studied. The results show that the antinociceptive effect of both single dose and prolonged administration of Ukrain is completely antagonized by Naltrexone.
Jagiello-Wójtowicz
E
E
Department of Pharmacology, Medical University School, Lublin, Poland.
Kleinrok
Z
Z
Gustaw
K
K
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001600:Berberine Alkaloids; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D009271:Naltrexone / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000494:pharmacology*; D010617:Phenanthridines
D000470:Alkaloids; D000970:Antineoplastic Agents; D001600:Berberine Alkaloids; D009292:Narcotic Antagonists; D010617:Phenanthridines; D009271:Naltrexone; C060921:ukrain