Steroidal saponins from the aerial parts of Dracaena draco and their cytostatic activity on HL-60 cells.
Chemical examination of the aerial parts of Dracaena draco has led to the isolation of a total of nine steroidal saponins, including five new ones. The structures of the new saponins were determined by spectral data and a few chemical transformations to be (23S,24S)-spirosta-5,25(27)-diene-1 beta,3 beta,23,24-tetrol 1-O-{O-(2,3,4-tri-O-acetyl-alpha-L-rhamnopyranosyl)-(1-->2)-alpha-L -arabinopyranosyl} 24-O-beta-D-fucopyranoside, (23S,24S)-spirosta-5,25(27)-diene-1 beta,3 beta, 23,24-tetrol 1-O-{O-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L -arabinopyranoside}, (23S,24S)-spirosta-5,25(27)-diene-1 beta,3 beta,23,24-tetrol 1-O-{O-(4-O- acetyl-alpha-L-rhamnopyranosyl)-(1-->2)-alpha-L-arabinopyransoide} , (23S)-spirosta-5,25(27)-diene-1 beta,3 beta,23-triol 1-O-{O-alpha-L- rhamnopyranosyl)-(1-->2)-alpha-L-arabinopyranoside} and (23S,24S)-spirosta-5,25(27)-diene-1 beta,3 beta,23-triol 1-O-{O-(4-O-acetyl-alpha-L-rhamnopyranosyl)-(1-->2)-alpha-L- arabinopyranoside}. The isolated saponins were evaluated for their cytostatic activity on leukemia HL-60 cells.
Mimaki
Y
Y
School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan. mimakiy@ps.toyaku.ac.jp
Kuroda
M
M
Ide
A
A
Kameyama
A
A
Yokosuka
A
A
Sashida
Y
Y
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D018922:HL-60 Cells / Q000187:drug effects*; D006801:Humans; D008968:Molecular Conformation; D015394:Molecular Structure; D010946:Plants, Medicinal; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D013150:Spirostans / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity
D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D013150:Spirostans