title: Clinicopathologic variables affecting survival of distal colorectal cancer patients with macroscopic invasion into the adjacent organs.
abstract: A total of 506 distal colorectal cancer patients were classified into two groups, to clarify the variables affecting survival of the patients with macroscopic invasion into the adjacent organs: 47 cases showed invasion (invasive group) while the other did not show invasion (noninvasive group). Differences between the invasive and noninvasive groups were found in eight variables; female, large tumor size, gross types 3 and 4, moderately or poorly differentiated adenocarcinomas and signet-ring cell or mucinous carcinomas, deep cancer invasion, lymphatic invasion, peritoneal and liver metastases, and curability B-C were found significantly more frequently in the invasive group. The survival curve of the former was significantly (P < 0.05) lower than that of the latter. However, no significant difference was found between the survival curves of the patients with curability A (no residual tumors) in both groups. A multivariate analysis in the invasive groups revealed six variables to be significantly related to a good prognosis including a young age, females, a location above the peritoneal reflection, well differentiated adenocarcinoma, negative lymphatic invasion, and curability A. Surgery with curability A should be performed to improve the survival in distal colorectal cancer patients with macroscopic invasion into the adjacent organs.
authors: First Department of Surgery, Kobe University School of Medicine, Japan.
authors: T
authors: T
authors: Nakamura
authors: H
authors: H
authors: Yoshioka
authors: M
authors: M
authors: Ohno
authors: T
authors: T
authors: Kuniyasu
authors: Y
authors: Y
authors: Tabuchi
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality; D002288:Adenocarcinoma, Mucinous / Q000401:mortality; D000367:Age Factors; D018279:Carcinoma, Signet Ring Cell / Q000401:mortality; D015179:Colorectal Neoplasms / Q000401:mortality* / Q000473:pathology*; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology; D008208:Lymphatic System / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D010537:Peritoneum / Q000473:pathology; D011379:Prognosis; D012737:Sex Factors; D015996:Survival Rate