Treatment of infected left ventricular assist device using antibiotic-impregnated beads.
There is no well-established therapy for treating infections of heart-assist or artificial heart devices, a serious problem with life-threatening consequences. We used a promising new approach in which antibiotic-impregnated polymethylmethacrylate beads were placed around an implanted left ventricular assist device to control an external blood pump infection in a bridge-to-transplant patient. In this case report, we describe the potential of antimicrobial-impregnated polymethylmethacrylate beads for in situ control of infections involving external surfaces of cardiovascular devices.
McKellar
S H
SH
Department of Cardiothoracic and Orthopedic Surgery, LDS Hospital, Salt Lake City, Utah 84103, USA.
Allred
B D
BD
Marks
J D
JD
Cowley
C G
CG
Classen
D C
DC
Gardner
S C
SC
Long
J W
JW
D003131:Combined Modality Therapy; D004343:Drug Implants; D004359:Drug Therapy, Combination / Q000008:administration & dosage; D016027:Heart Transplantation; D006353:Heart-Assist Devices; D006801:Humans; D008297:Male; D008875:Middle Aged; D019904:Polymethyl Methacrylate; D016459:Prosthesis-Related Infections / Q000601:surgery*; D012086:Reoperation; D013203:Staphylococcal Infections / Q000601:surgery*; D013212:Staphylococcus epidermidis; D014031:Tobramycin / Q000008:administration & dosage*; D014640:Vancomycin / Q000008:administration & dosage*
D004343:Drug Implants; D014640:Vancomycin; D019904:Polymethyl Methacrylate; D014031:Tobramycin