Effects of Corylus avellana in acetaminophen and CCl4 induced toxicosis.
Our study investigated the effects of Corylus avellana extract on acetaminophen and carbon tetrachloride intoxicated liver of young rats. Hepatocytolysis was determined by measuring the level of serum transaminases (GPT and GOT), steatosis by Sudan black staining, histological structures by hamatoxylineosin staining and the activity of enzymes such as SDH, GtDH, G-6-Pase and ATPase. Comparatively, the most serious lesions appeared in CCl4 intoxication. Corylus avellana extract had some beneficial effects in CCl4 toxicosis: it reduced hepatocytolysis as well as histological lesions and returned the activity of some enzymes to normal values.
Rusu
M A
MA
Biological Research Institute, Cluj-Napoca, Romania.
Bucur
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N
Puică
C
C
Tămaş
M
M
D000082:Acetaminophen / Q000633:toxicity*; D018712:Analgesics, Non-Narcotic / Q000633:toxicity*; D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury; D004195:Disease Models, Animal; D008107:Liver Diseases / Q000201:enzymology / Q000517:prevention & control*; D008111:Liver Function Tests; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D018712:Analgesics, Non-Narcotic; D010936:Plant Extracts; D000082:Acetaminophen; D002251:Carbon Tetrachloride