The presentation and management of post-partum choriocarcinoma.
Post-partum choriocarcinoma is a rare complication of pregnancy. We have analysed a series of nine consecutive patients presenting with choriocarcinoma after a full-term non-molar pregnancy. All patients were managed at the Supraregional Trophoblastic Disease Screening and Treatment Centre at Weston Park Hospital, Sheffield between 1987 and 1996. All presented with persistent primary or secondary post-partum haemorrhage. Treatment with multiagent chemotherapy (initially methotrexate, dactinomycin and etoposide) was successful in all cases. Early diagnosis is important because this rare condition is potentially curable with appropriate chemotherapy.
Dobson
L S
LS
Trophoblastic Disease Screening and Treatment Centre, YCR Section of Clinical Oncology, Weston Park Hospital, Sheffield, UK.
Gillespie
A M
AM
Coleman
R E
RE
Hancock
B W
BW
D000328:Adult; D000931:Antidotes / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D002822:Choriocarcinoma / Q000150:complications / Q000188:drug therapy* / Q000556:secondary; D003520:Cyclophosphamide / Q000008:administration & dosage; D003609:Dactinomycin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008727:Methotrexate / Q000008:administration & dosage; D006473:Postpartum Hemorrhage / Q000209:etiology; D049590:Postpartum Period; D011247:Pregnancy; D012189:Retrospective Studies; D014594:Uterine Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D014750:Vincristine / Q000008:administration & dosage
D000931:Antidotes; D003609:Dactinomycin; D014750:Vincristine; D005047:Etoposide; D003520:Cyclophosphamide; D016190:Carboplatin; D002955:Leucovorin; D008727:Methotrexate