An evaluation of a chemical cautery agent and an anti-inflammatory ointment for the treatment of recurrent aphthous stomatitis: a pilot study.
OBJECTIVE
Recurrent aphthous stomatitis is a very common condition, currently treated with anti-inflammatory agents, which palliate the symptoms. The purpose of this clinical trial was to compare a medication commonly used to treat recurrent aphthous stomatitis, Kenalog-in-Orabase, and a newer agent, Debacterol.


METHODS
Sixty patients diagnosed with recurrent aphthous stomatitis were enrolled in the study. Twenty patients were assigned to each of the two treatment groups, and 20 age- and sex-matched patients were assigned to the control group, which received no treatment. After the diagnosis was made, clinical examinations and ulcer measurements were performed, and a subjective evaluation of symptoms (100-mm visual analog scale) was completed by each subject. The subjects did not use any other medications. Both agents were applied topically (the frequency varied depending on the group of subjects) at specified intervals. Ulcer measurements and subjective evaluations were made at days 0, 3, 6, and 10 for all subjects.


RESULTS
In both treatment groups, by day 10, 100% of the ulcers had clinically healed and were no longer causing pain. Patients in the Debacterol group reported a significantly greater decrease in pain at 3 days (> 70%) than did subjects in the other groups (< 20%), although the size of the ulcer did not differ significantly in any of the groups. After day 6, 80% of the ulcers in the Debacterol group had clinically disappeared and no longer caused symptoms, as compared to about 30% in the other groups.


CONCLUSIONS
Patients subjectively reported significantly greater relief from symptoms with Debacterol than with Kenalog-in-Orabase or no treatment. The relief of symptoms associated with recurrent aphthous stomatitis may or may not correspond to clinical improvement, and these two topical medications may affect signs and symptoms of the lesions differently.
Rhodus
N L
NL
Division of Oral Medicine, University of Minnesota, School of Dentistry, Minneapolis 55455, USA. rhodu001@maroon.tc.umn.edu
Bereuter
J
J
D000287:Administration, Topical; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002266:Carboxymethylcellulose Sodium / Q000031:analogs & derivatives / Q000627:therapeutic use; D002424:Caustics / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D005938:Glucocorticoids; D006801:Humans; D008297:Male; D010147:Pain Measurement; D010636:Phenols; D010865:Pilot Projects; D012008:Recurrence; D013281:Stomatitis, Aphthous / Q000188:drug therapy*; D013464:Sulfuric Acids; D014222:Triamcinolone Acetonide / Q000627:therapeutic use*
D000893:Anti-Inflammatory Agents; D002424:Caustics; D004338:Drug Combinations; D005938:Glucocorticoids; D010636:Phenols; D013464:Sulfuric Acids; C118367:sufuric acid, sulfonated phenol drug combination; C056627:Orabase; D014222:Triamcinolone Acetonide; D002266:Carboxymethylcellulose Sodium