[Expression of receptors for human alpha- and gamma-interferons on the surface of peripheral blood mononuclear cells in viral infections].
Expression of receptors on peripheral blood mononuclears of donors and patients with viral infections during therapy was studied using FITC-labeled monoclonal antiidiotypical antibodies with the "internal image" of human alpha- and gamma-interferons and monoclonal antibodies to these interferons. Activation of the immune system caused by infection modifies the expression of interferon receptors and leads to appearance of membrane-bound interferons, mainly gamma-interferon.
Barkova
E P
EP
Nagieva
F G
FG
Kuznetsov
V P
VP
Beliaev
D L
DL
Nikulina
V G
VG
Babaiants
A A
AA
Krel'
P E
PE
Andzhaparidze
O G
OG
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D000911:Antibodies, Monoclonal / Q000276:immunology; D002522:Chlorocebus aethiops; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D053633:Receptor, Interferon alpha-beta; D017471:Receptors, Interferon / Q000276:immunology*; D014709:Vero Cells; D014777:Virus Diseases / Q000276:immunology*; D000096743:Interferon gamma Receptor
D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D053633:Receptor, Interferon alpha-beta; D017471:Receptors, Interferon; D000096743:Interferon gamma Receptor