Dioxin and dibenzofuran concentrations in adipose tissue of a general population from Tarragona, Spain.
Polychlorinated dibenzo-p-dioxin (PCDD) and polychlorinated dibenzofuran (PCDF) levels were determined in adipose tissue of 15 autopsied subjects who at the time of death had lived in the city of Tarragona (Catalonia, Spain) and surroundings during at least the last 10 years. PCDD/F concentrations ranged between 13.37 and 69.37 ng I-TEQ/kg fat, with mean and median values of 30.98 and 26.30 ng I-TEQ/kg fat, respectively. PCDD/F concentrations were higher (p < 0.01) in women (mean value: 44.95 ng I-TEQ/kg fat) than in men (mean value: 24.00 ng I-TEQ/kg fat). Although individuals living in industrial areas showed higher PCDD/F levels than those living Tarragona downtown the difference was not statistically significant. When Principal Component Analysis was applied to the concentrations of PCDD/Fs found in the 15 adipose tissue samples together with those found in 20 blood samples collected in a previous study, a single two-dimensional model was obtained, which would explain 62.9% of the variance in the data. The PCDD/F concentrations in adipose tissue found in the current study are of the same order of magnitude than those reported for most industrialized countries.
Schuhmacher
M
M
Environmental Engineering Laboratory, Rovira i Virgili University, Tarragona, Spain.
Domingo
J L
JL
Llobet
J M
JM
Lindström
G
G
Wingfors
H
H
D000273:Adipose Tissue / Q000737:chemistry*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001572:Benzofurans / Q000032:analysis*; D000072338:Dibenzofurans, Polychlorinated; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007220:Industrial Waste; D008297:Male; D008875:Middle Aged; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives* / Q000032:analysis; D013030:Spain
D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D007220:Industrial Waste; D000072317:Polychlorinated Dibenzodioxins