Clinical considerations in GERD (gastroesophageal reflux disease) therapy: focus on cisapride.
Heartburn, the major symptom of gastrointestinal reflux disease (GERD), is a common condition that is usually self-treated with over-the-counter products. For patients with severe or recurrent symptoms of GERD, pharmacologic therapy includes acid suppression with H2-receptor antagonists and proton pump inhibitors, and, alternatively, the use of prokinetic agents. While all of these are efficacious, given its high efficacy in nonerosive and mild-to-moderate erosive esophagitis, the prokinetic agent cisapride deserves significant consideration in this patient population.
Snape
W J
WJ
D020117:Cisapride; D019468:Disease Management; D005764:Gastroesophageal Reflux / Q000188:drug therapy* / Q000453:epidemiology* / Q000503:physiopathology; D005765:Gastrointestinal Agents / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008019:Life Style; D008329:Managed Care Programs; D010880:Piperidines / Q000009:adverse effects / Q000627:therapeutic use*; D011788:Quality of Life; D014481:United States
D005765:Gastrointestinal Agents; D010880:Piperidines; D020117:Cisapride