[New approaches to antitumor therapy of various morphological variants of primary bone sarcoma].
The data of foreign literature and original findings on possible role of auto-, paracrine and endocrine mechanisms of bone sarcoma growth regulation are reviewed basing on observation in these tumors of receptors of the epidermal growth factor (REGF), EGF-like peptides, receptors of glucocorticoids, androgens and estrogens. Link of these indices with clinicomorphological characteristics of the disease and its prognosis is suggested. REGF in primary bone tumors may serve as targets for therapy with drugs influencing EGF-dependent mechanism of tumor growth stimulation. Groups of these drugs are considered in detail.
Kushlinskiĭ
N E
NE
N. N. Blokhin Cancer Research Centre, Moscow.
Solov'ev
Iu N
IuN
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D019898:Autocrine Communication; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000473:pathology; D004703:Endocrine System / Q000502:physiology; D004815:Epidermal Growth Factor / Q000502:physiology; D006801:Humans; D019899:Paracrine Communication; D012509:Sarcoma / Q000188:drug therapy* / Q000473:pathology
D000970:Antineoplastic Agents; D004815:Epidermal Growth Factor