title: Endogenous catecholamine synthesis, metabolism, storage and uptake in human neutrophils.
abstract: Evidence is presented that human neutrophils contain catecholamines and several of their metabolites. In vitro, incubation with alpha-methyl-p-tyrosine or pargyline affects intracellular dopamine, norepinephrine and their metabolites, suggesting catecholamine synthesis and degradation by these cells. Reserpine reduces intracellular dopamine and norepinephrine and desipramine reduces intracellular norepinephrine, suggesting the presence of storage and uptake mechanism. In view of the ability of catecholamines to affect neutrophil function, the present results support the hypothesis that autoregulatory adrenergic mechanisms may exist in these cells.
authors: Department of Internal Medicine and Therapeutics, University of Insubria, Varese, Italy.
authors: M
authors: M
authors: Cosentino
authors: F
authors: F
authors: Marino
authors: R
authors: R
authors: Bombelli
authors: M
authors: M
authors: Ferrari
authors: S
authors: S
authors: Lecchini
authors: G
authors: G
authors: Frigo
mesh_terms: D000328:Adult; D002395:Catecholamines / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D009504:Neutrophils / Q000378:metabolism*; D019805:alpha-Methyltyrosine / Q000494:pharmacology
chemical_list: D002395:Catecholamines; D019805:alpha-Methyltyrosine