Determination of bezafibrate concentration by high performance liquid-chromatography in serum of rats treated with lead nitrate.
In the present study, the bezafibrate levels were measured in serum of rats treated with lead nitrate using a high performance liquid chromatography (HPLC) method. The results have shown that the peak corresponding to bezafibrate in the chromatogram is reduced in serum of rats treated with bezafibrate plus lead, indicating that lead treatment accelerates the metabolism of bezafibrate in rats.
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Dipartimento Farmaco Chimico Tecnologico, Facoltà di Farmacia, Cagliari, Italy.
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D000284:Administration, Oral; D000818:Animals; D001629:Bezafibrate / Q000097:blood* / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D004347:Drug Interactions; D000960:Hypolipidemic Agents / Q000097:blood* / Q000378:metabolism; D007275:Injections, Intravenous; D007854:Lead / Q000494:pharmacology*; D008297:Male; D008934:Mitogens / Q000494:pharmacology*; D009566:Nitrates / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000960:Hypolipidemic Agents; D008934:Mitogens; D009566:Nitrates; D007854:Lead; C017461:lead nitrate; D001629:Bezafibrate