A comparative study of root-end induction using osteogenic protein-1, calcium hydroxide, and mineral trioxide aggregate in dogs.
Calcium hydroxide has been the material of choice for apexification. The purpose of this study was to compare the efficacy of osteogenic protein-1 and mineral trioxide aggregate with that of calcium hydroxide in the formation of hard tissue in immature roots of dogs. Sixty-four roots of premolars were used. After induction of periradicular lesions, the canals were debrided and filled with calcium hydroxide for 1 wk. After the removal of calcium hydroxide, the root canals received one of the treatment materials in a balanced design. The animals were euthanized 12 wk later. The degree of hard tissue formation and amount of inflammation were evaluated histomorphically. Data were statistically evaluated using ANOVA, chi 2, and Kruskal-Wallis. Mineral trioxide aggregate produced apical hard tissue formation with significantly greater consistency. The difference in the amount of hard tissue produced among the three test materials was not statistically significant. Furthermore, the degree of inflammation was not significantly different between the various test groups.
Shabahang
S
S
Department of Endodontics, School of Dentistry, Loma Linda University, CA 92350, USA.
Torabinejad
M
M
Boyne
P P
PP
Abedi
H
H
McMillan
P
P
D017607:Aluminum Compounds / Q000494:pharmacology; D000704:Analysis of Variance; D000818:Animals; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins / Q000494:pharmacology; D017610:Calcium Compounds / Q000494:pharmacology; D002126:Calcium Hydroxide / Q000494:pharmacology; D016009:Chi-Square Distribution; D003094:Collagen; D003809:Dentin, Secondary / Q000254:growth & development*; D004285:Dogs; D004338:Drug Combinations; D005069:Evaluation Studies as Topic; D010087:Oxides / Q000494:pharmacology; D017640:Silicates / Q000494:pharmacology; D018709:Statistics, Nonparametric; D019227:Tooth Apex / Q000187:drug effects* / Q000254:growth & development*; D016212:Transforming Growth Factor beta
D017607:Aluminum Compounds; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D017610:Calcium Compounds; D004338:Drug Combinations; D010087:Oxides; D017640:Silicates; D016212:Transforming Growth Factor beta; C086631:mineral trioxide aggregate; D003094:Collagen; D002126:Calcium Hydroxide