title: The relationship of the platelet 5-HT-induced calcium response to clinical symptoms in eating disorders.
abstract: Clinical observations indicate that persons with eating disorders exhibit many psychopathologic symptoms such as difficulty with impulse control and depressed mood associated with impaired regulation of serotonin (5-HT) synaptic function in the central nervous system. In this study, we focused on the relationship between the 5-HT-induced calcium response in platelets and the clinical symptoms. While age, body weight, and severity of depressive symptoms were not correlated with 5-HT-induced response, there was an enhanced response in patients with bulimic symptoms or other impulsive behaviors. Moreover, patients with multi-impulsive behaviors had a significantly higher maximal increase than patients with uni-impulsive behavior, i.e., those who had only bulimic symptoms, as well as non-impulsive patients, and controls. Considering these results, the 5-HT-induced response may be related to difficulty with impulse control in general rather than bulimic eating attitudes specifically.
authors: Department of Psychiatry and Neurosciences, Hiroshima University School of Medicine, Japan.
authors: Y
authors: Y
authors: Okamoto
authors: Y
authors: Y
authors: Okamoto
authors: A
authors: A
authors: Kagaya
authors: J
authors: J
authors: Horiguchi
authors: S
authors: S
authors: Yamawaki
mesh_terms: D000328:Adult; D000367:Age Factors; D001792:Blood Platelets / Q000378:metabolism*; D001835:Body Weight; D002118:Calcium / Q000378:metabolism*; D003863:Depression / Q000150:complications / Q000378:metabolism; D005247:Feeding Behavior; D001068:Feeding and Eating Disorders / Q000150:complications / Q000378:metabolism* / Q000523:psychology; D005260:Female; D006801:Humans; D007175:Impulsive Behavior; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000502:physiology*; D012621:Seasons
chemical_list: D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin; D002118:Calcium