[A case of mononeuropathy multiplex associated with anti-GM1 and -SGLPG antibodies in a patient with ongoing Hashimoto disease].
We reported a case of mononeuropathy multiplex associated with anti-GM1 and -SGLPG antibodies in a patient with ongoing Hashimoto disease. A 56-year-old woman was admitted with asymmetrical patchy sensory and motor disturbance in the extremities. Muscle atrophy and weakness in the left palm and bilateral tibialis anterior muscles were also noted. Deep tendon reflexes were normal in all the extremities. Superficial and deep sensations were reduced in the hands and feet bilaterally, and the distribution of sensory loss was irregular. Her serum was positive for antinuclear antibody, rheumatoid factor, anti-RNP antibody, and anti-SS-A antibody. Serial electrophysiological studies suggested that the predominant process was axonal degeneration of the sensorimotor nerves. On sural nerve biopsy, there were no findings of vasculitis but severe axonal degeneration was observed. Thin-layer chromatography with immunostaining revealed anti-GM1 and -SGLPG antibodies. Treatment with corticosteroids was successful. In this case, the anti-GM1 antibody may have played a role in the pathogenesis of mononeuropathy multiplex associated with autoimmune disease.
Nishihara
T
T
Department of Internal Medicine, Takamatsu Red Cross Hospital.
Hashiguchi
S
S
Ogasawara
N
N
Shirabe
T
T
Yoshino
H
H
D001323:Autoantibodies / Q000097:blood*; D005260:Female; D005677:G(M1) Ganglioside / Q000276:immunology*; D005915:Globosides / Q000276:immunology*; D006801:Humans; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000276:immunology*; D013967:Thyroiditis, Autoimmune / Q000276:immunology*
D001323:Autoantibodies; D005915:Globosides; C064938:3-sulfoglucuronyl-lactosaminyl-paragloboside; D005677:G(M1) Ganglioside