The subapical compartment: a novel sorting centre?
Establishment of plasma membrane polarity involves numerous intracellular sorting events. In the past few years, it has become apparent that there is a subapical, non-Golgi compartment located in the hub of the sorting pathways involved. This 'subapical compartment', which probably consists of a heterogeneous subset of functionally distinct domains related to endosomes, contains some well-characterized components involved in polarity-dependent sorting and targeting of proteins and lipids. This article discusses the evidence supporting the existence of such a compartment, its biogenesis and its role in cell polarity.
van IJzendoorn
S C
SC
Dept of Physiological Chemistry, Faculty of Medical Sciences, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands.
Hoekstra
D
D
D000818:Animals; D001692:Biological Transport / Q000502:physiology*; D002451:Cell Compartmentation; D002460:Cell Line; D016764:Cell Polarity; D004285:Dogs; D004705:Endocytosis; D011992:Endosomes / Q000502:physiology* / Q000648:ultrastructure; D006056:Golgi Apparatus / Q000502:physiology; D008563:Membrane Lipids / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D008870:Microtubules / Q000502:physiology; D008954:Models, Biological
D008563:Membrane Lipids; D008565:Membrane Proteins