[Bone and hormones. Effects of growth hormone on bone tissue in adults].
GROWTH HORMONE INSUFFICIENCY: Bone mass is reduced and bone remodeling diminished in case of growth hormone insufficiency. ACROMEGALY: In acromegaly, cortical bone mass increases due to excessive growth hormone. The effect on trabecular bone is less well established. ON THE CELLULAR LEVEL: Growth hormone stimulates the bone formation action of osteoblasts and their synthesis of insulin-like growth factor I. EFFECTS OF TREATMENT: Contradictory results have been obtained in adults treated with growth hormone for insufficiency. Generally, markers of bone remodeling are increased, but the effect on bone density is less clear. Long-term studies are needed. EFFICACY OF GROWTH HORMONE TREATMENT ON OSTEOPOROSIS: Growth hormone has been found to have an effect. Several randomized trials have demonstrated moderate increases in bone density.
Chapurlat
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Service de Rhumatologie et de Pathologie Osseuse, Hôpital Edouard Herriot, Lyon.
Delmas
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D000172:Acromegaly / Q000503:physiopathology; D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology; D000818:Animals; D015519:Bone Density; D016723:Bone Remodeling; D001842:Bone and Bones / Q000187:drug effects* / Q000502:physiology; D002648:Child; D004285:Dogs; D005260:Female; D013006:Growth Hormone / Q000172:deficiency / Q000494:pharmacology* / Q000502:physiology* / Q000627:therapeutic use; D006801:Humans; D008253:Macaca mulatta; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D016032:Randomized Controlled Trials as Topic
D013006:Growth Hormone