title: Attitudes toward colon cancer gene testing: factors predicting test uptake.
abstract: OBJECTIVE
  Genetic discoveries in hereditary nonpolyposis colorectal cancer (HNPCC) have made possible genetic testing to determine susceptibility to this form of colorectal cancer (CRC). This study measured the uptake of genetic testing for HNPCC among first-degree relatives of CRC patients and conducted a preliminary analysis of the predictors of test uptake.
  
  
  METHODS
  We compared 77 test acceptors and 181 decliners on demographic, medical history, and psychological characteristics, controlling for distance from the testing center. The psychological factors studied were risk perception for CRC, frequency of cancer thoughts, and perceived ability to cope with unfavorable genetic information.
  
  
  RESULTS
  In the final regression model, after accounting for all variables, the significant predictors of test uptake were increased risk perception, greater perceived confidence in ability to cope with unfavorable genetic information, more frequent cancer thoughts, and having had at least one colonoscopy. The association between risk perception and uptake was dependent on frequency of cancer thoughts. Among those who thought about getting CRC more often, the probability of testing increased as perceived risk increased to approximately 50% likelihood of getting CRC and then leveled off. In contrast, among those who never or rarely thought about getting CRC, risk perception was unrelated to testing decision.
  
  
  CONCLUSIONS
  Our findings are consistent with the associations reported between psychological factors and other cancer screening behaviors.
authors: Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21287-7218, USA. acodori@welchlink.welch.jhu.edu
authors: A M
authors: AM
authors: Codori
authors: G M
authors: GM
authors: Petersen
authors: D L
authors: DL
authors: Miglioretti
authors: E K
authors: EK
authors: Larkin
authors: M T
authors: MT
authors: Bushey
authors: C
authors: C
authors: Young
authors: J D
authors: JD
authors: Brensinger
authors: K
authors: K
authors: Johnson
authors: J A
authors: JA
authors: Bacon
authors: S V
authors: SV
authors: Booker
mesh_terms: D000223:Adaptation, Psychological; D000368:Aged; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000517:prevention & control* / Q000523:psychology*; D005190:Family / Q000523:psychology*; D005260:Female; D005817:Genetic Counseling / Q000523:psychology* / Q000706:statistics & numerical data*; D005820:Genetic Testing / Q000523:psychology* / Q000706:statistics & numerical data*; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010342:Patient Acceptance of Health Care / Q000523:psychology*; D012042:Registries; D012044:Regression Analysis; D012307:Risk Factors; D011795:Surveys and Questionnaires