title: Lupus-like syndrome caused by 5-aminosalicylic acid in patients with inflammatory bowel disease.
abstract: BACKGROUND
  Although 5-aminosalicylic acid (5-ASA) preparations used to treat inflammatory bowel disease are reported to have fewer side effects than sulphasalazine, increased clinical use of these compounds has resulted in increased reports of significant side effects.
  
  
  OBJECTIVE
  To report four patients with antinuclear antibody-positive migratory arthralgias and acute inflammation unrelated to the underlying inflammatory bowel disease, fulfilling the criteria of a drug-induced lupus-like syndrome.
  
  
  METHODS
  A university-affiliated teaching hospital.
  
  
  METHODS
  Cessation of treatment with 5-ASA compounds.
  
  
  RESULTS
  The cases described constitute a drug-induced lupus-like syndrome. All patients improved rapidly after discontinuation of 5-ASA compounds.
  
  
  CONCLUSIONS
  Reversible lupus-like syndrome appears to be a rare but significant side effect of 5-ASA compounds. Patients treated with 5-ASA compounds who experience acute inflammatory symptoms or clinical deterioration not related to their gastrointestinal disease should be screened to rule out a lupus-like reaction.
authors: Vancouver Hospital and Health Sciences Centre, Vancouver, Canada.
authors: A W
authors: AW
authors: Kirkpatrick
authors: A A
authors: AA
authors: Bookman
authors: F
authors: F
authors: Habal
mesh_terms: D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D000974:Antibodies, Antinuclear / Q000032:analysis; D003240:Connective Tissue Diseases / Q000139:chemically induced*; D003424:Crohn Disease / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced*; D008297:Male; D019804:Mesalamine / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000974:Antibodies, Antinuclear; D019804:Mesalamine