title: Phenolic aporphine-benzylisoquinoline alkaloids from Thalictrum faberi.
abstract: From the roots of Thalictrum faberi, six new phenolic aporphine-benzylisoquinoline alkaloids, 3-hydroxy-6'-desmethyl-9-O-methylthalifaboramine (1), 3-hydroxythalifaboramine (2), 6'-desmethylthalifaboramine (3); 3,5'-dihydroxythalifaboramine (4), 5'-hydroxythalifaboramine (5) and 3-hydroxy-6'-desmethylthalifaboramine (6) were isolated. Their structures were established through the use of one- and two-dimensional NMR techniques. All of the tested alkaloids showed potent cytotoxic and antimalarial activities.
authors: Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago 60612-7231, USA.
authors: L Z
authors: LZ
authors: Lin
authors: S F
authors: SF
authors: Hu
authors: M
authors: M
authors: Chu
authors: T M
authors: TM
authors: Chan
authors: H
authors: H
authors: Chai
authors: C K
authors: CK
authors: Angerhofer
authors: J M
authors: JM
authors: Pezzuto
authors: G A
authors: GA
authors: Cordell
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D000818:Animals; D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D000962:Antimalarials / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D001060:Aporphines / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D002681:China; D006801:Humans; D007546:Isoquinolines / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D007624:KB Cells; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D010946:Plants, Medicinal; D010963:Plasmodium falciparum / Q000187:drug effects; D018894:Reverse Transcriptase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D014407:Tumor Cells, Cultured
chemical_list: D000470:Alkaloids; D019380:Anti-HIV Agents; D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D001060:Aporphines; D007546:Isoquinolines; D010636:Phenols; D018894:Reverse Transcriptase Inhibitors; C081279:aporphine