Central vasopressin is modulated by chronic blockade of the renin-angiotensin system in experimental left ventricular hypertrophy.
We studied the interaction of the central renin-angiotensin system (RAS) and vasopressin system in rats with left ventricular hypertrophy (LVH) due to aortic banding. In these animals plasma vasopressin is elevated and vasopressin content is increased in specific brain areas. Chronic blockade of the RAS by angiotensin-converting enzyme (ACE) inhibition (ramipril) and AT1 receptor antagonism (losartan) significantly attenuated circulating and central vasopressin in rats with LVH. Given the antidiuretic, vasoconstrictive, and growth-promoting effects, vasopressin may participate in the cardiovascular alterations in LVH. Blockade of the RAS strongly ameliorates central and peripheral-vasopressin. Therefore, central modulatory effects on vasopressin might contribute to the therapeutic efficacy of ACE inhibitors and AT1 antagonists.
Muders
F
F
Klinik und Poliklinik für Innere Medizin II, University of Regensburg, Germany.
Elsner
D
D
Schunkert
H
H
Riegger
G A
GA
Palkovits
M
M
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure; D001923:Brain Chemistry / Q000187:drug effects; D017379:Hypertrophy, Left Ventricular / Q000378:metabolism / Q000503:physiopathology*; D019808:Losartan / Q000494:pharmacology; D017257:Ramipril / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012084:Renin-Angiotensin System / Q000187:drug effects; D014667:Vasopressins / Q000097:blood*
D000806:Angiotensin-Converting Enzyme Inhibitors; D014667:Vasopressins; D019808:Losartan; D017257:Ramipril