Chromosomal mapping of five mouse G protein gamma subunits.
Heterotrimeric G proteins, composed of alpha, beta, and gamma subunits, transduce signals from transmembrane receptors to a wide range of intracellular effectors. The G protein gamma subunits, which play an indispensible role in this communication, constitute a large and diverse multigene family. Using an interspecific backcross panel, we have determined the mouse chromosomal locations of five gamma subunit genes: gamma2, gamma8, gamma10, gamma12, and gammaCone. Combined with previous mapping studies, these data indicate that, with the possible exception of gamma1 and gamma11, the G protein gamma subunit genes are well dispersed within the mouse and human genomes.
Downes
G B
GB
Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, 63110, USA.
Gilbert
D J
DJ
Copeland
N G
NG
Gautam
N
N
Jenkins
N A
NA
D000818:Animals; D002874:Chromosome Mapping; D019204:GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D007178:Inbreeding; D051379:Mice; D008957:Models, Genetic; D008969:Molecular Sequence Data; D012150:Polymorphism, Restriction Fragment Length
D019204:GTP-Binding Proteins