title: Anti-epiligrin cicatricial pemphigoid with IgG autoantibodies to the beta and gamma subunits of laminin 5.
abstract: Anti-epiligrin cicatricial pemphigoid is an autoimmune subepithelial blistering disorder of mucous membranes and skin. By immunoblot analyses, sera of most patients with antiepiligrin cicatricial pemphigoid have been shown to react specifically with the alpha3 chain of laminin 5. We describe the first patient with anti-epiligrin cicatricial pemphigoid in whom circulating IgG autoantibodies directed against the beta3 and gamma2-chains of laminin 5 were detected. Treatment with oral prednisolone was beneficial in controlling the disease.
authors: Department of Dermatology, Okayama University Medical School, Japan.
authors: W
authors: W
authors: Fujimoto
authors: Y
authors: Y
authors: Toi
authors: F
authors: F
authors: Okazaki
authors: Z
authors: Z
authors: Lazarova
authors: K B
authors: KB
authors: Yancey
authors: J
authors: J
authors: Arata
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D015815:Cell Adhesion Molecules / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008297:Male; D016253:Microscopy, Immunoelectron; D010390:Pemphigoid, Benign Mucous Membrane / Q000175:diagnosis / Q000276:immunology*; D000097794:Kalinin
chemical_list: D001323:Autoantibodies; D015815:Cell Adhesion Molecules; D007074:Immunoglobulin G; D000097794:Kalinin