title: Ileal short-chain fatty acids inhibit transpyloric flow in pigs.
abstract: BACKGROUND
  Short-chain fatty acids (SCFA) found in the ileum after caecoileal reflux might trigger a physiologic ileal brake similar that induced by ileal nutrient infusion. This study evaluates gastric emptying and motility after ileal administration of SCFA.
  
  
  METHODS
  In eight conscious pigs gastric emptying was evaluated by double dilution (liquids) and direct measurement of duodenal effluent (liquids and solids) during ileal infusions of SCFA and isotonic and hypertonic saline. Antropyloroduodenal manometry and flow were recorded concurrently.
  
  
  RESULTS
  Ileal SCFA significantly delayed gastric emptying of liquids and solids. During SCFA infusion the emptying pattern of liquids was less pulsatile, and flow pulses had a smaller stroke volume than during isotonic saline. The antroduodenal pressure gradient was decreased, whereas pyloric tone was increased. A reduced number of antral pressure waves occurred together with an increased frequency of isolated pyloric pressure waves.
  
  
  CONCLUSIONS
  Ileal SCFA infusion delays gastric emptying of liquid and solid as a consequence of a decreased antral and increased pyloric motility.
authors: Flux Digestifs et Métabolisme Protéique' Unit, Porcine Research Station, INRA, Saint Gilles, France.
authors: G
authors: G
authors: Cuche
authors: C H
authors: CH
authors: Malbert
mesh_terms: D000818:Animals; D005232:Fatty Acids, Volatile / Q000494:pharmacology; D005260:Female; D005746:Gastric Emptying; D005769:Gastrointestinal Motility; D007082:Ileum / Q000502:physiology*; D008365:Manometry; D011706:Pyloric Antrum / Q000502:physiology; D011708:Pylorus / Q000502:physiology*; D013552:Swine
chemical_list: D005232:Fatty Acids, Volatile