title: Thermotherapy: feasibility study using a single focussed ultrasound transducer.
abstract: Feasibility studies on tissue lesioning using high intensity focussed ultrasound (HIFU) thermotherapy were carried out. A single strongly focussed transducer was used. The transducer has a diameter of 50 mm, a centre resonance frequency of 1 MHz and a focal distance of 50mm. Experiments were carried out both in vitro on pig muscle samples and in vivo on a pig (exposures on the thigh and on the liver). Different types of burst pulse signals were used, the best results were obtained with 1-2 s burst pulses, with a repetition period of 10s. The risk for skin damage increases for longer burst pulses. Lesions at the focus were obtained both in the experiments in vitro as well as in vivo. The size and the shape of the lesions in vivo resemble those obtained in vitro. The results of the experiments show that tissue lesions can be obtained at deep locations (4.5 cm in the tissue) with the transducer. The lesions were well discriminated from the surrounding tissue and were ellipsoid- or drop-shaped. The lesion size can be controlled by the choice of time parameters of the burst pulse signal, power and treatment time. Temperatures of about 80 degrees C were measured in the tissue at the ultrasound focus in vitro. These results show that elevated temperatures can be induced rapidly at the focus, thus reducing the effect of heat dissipation through blood perfusion.
authors: Department of Biomedical Engineering MT-K, Lund University, University Hospital, Sweden.
authors: C A
authors: CA
authors: Barkman
authors: L O
authors: LO
authors: Almquist
authors: T
authors: T
authors: Kirkhorn
authors: N G
authors: NG
authors: Holmer
mesh_terms: D000818:Animals; D005240:Feasibility Studies; D006979:Hyperthermia, Induced / Q000379:methods*; D013552:Swine; D014465:Ultrasonics