Determination of an optimal dosing regimen for aspirin chemoprevention of 1,2-dimethylhydrazine-induced colon tumours in rats.
In order to establish an optimal timing and duration of aspirin treatment in the chemoprevention of 1,2-dimethylhydrazine (DMH)-induced colon cancer in rats, colon tumours were induced using an established protocol and aspirin was given in the diet at 500 p.p.m. during various stages of colon carcinogenesis. Results indicate that only aspirin treatment throughout the entire carcinogenic period significantly reduced tumour incidence and volume whereas intermittent aspirin dosing increased tumour number and/or volume, suggesting that aspirin must be used for an extended period in order to gain any chemopreventive benefit.
Barnes
C J
CJ
Department of Medicine, University of Texas Health Science Center, and Veterans Affairs Medical Center, San Antonio 78284, USA.
Lee
M
M
D019813:1,2-Dimethylhydrazine / Q000633:toxicity*; D000818:Animals; D001241:Aspirin / Q000627:therapeutic use*; D002273:Carcinogens / Q000633:toxicity*; D018890:Chemoprevention; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D009367:Neoplasm Staging; D051381:Rats; D017207:Rats, Sprague-Dawley
D002273:Carcinogens; D019813:1,2-Dimethylhydrazine; D001241:Aspirin