Virilizing ovarian dermoid cyst with peripheral steroid cells. A case study with immunohistochemical study of steroidogenesis.
A case of virilizing ovarian dermoid cyst with peripheral steroid cells and virilization is reported in a 62-year-old woman. The level of testosterone dropped to normal after oophorectomy. The cyst wall was bordered by a discontinuous band of steroid cells focally accompanied by smooth muscle cells. Immunohistochemically, the steroid cells were enzymatically active and displayed a profile similar to the internal theca cells of ovarian follicles. These steroid cells were most probably modified stromal cells associated with smooth muscle metaplasia of the ovarian stroma.
Boman
F
F
Department of Pathology, University of Lille II, France.
Vantyghem
M C
MC
Querleu
D
D
Sasano
H
H
D004268:DNA-Binding Proteins / Q000378:metabolism; D003884:Dermoid Cyst / Q000097:blood / Q000150:complications* / Q000378:metabolism / Q000473:pathology*; D005260:Female; D051717:Fushi Tarazu Transcription Factors; D006628:Hirsutism / Q000097:blood / Q000209:etiology; D018398:Homeodomain Proteins; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000097:blood / Q000150:complications* / Q000378:metabolism / Q000473:pathology*; D010088:Oxidoreductases / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear; D054339:Steroidogenic Factor 1; D013739:Testosterone / Q000097:blood; D014157:Transcription Factors / Q000378:metabolism; D014770:Virilism / Q000097:blood / Q000209:etiology*
D004268:DNA-Binding Proteins; D051717:Fushi Tarazu Transcription Factors; D018398:Homeodomain Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D054339:Steroidogenic Factor 1; D014157:Transcription Factors; D013739:Testosterone; D010088:Oxidoreductases