title: Expression and regulation of collagenase-3 (MMP-13) in human malignant tumors.
abstract: Human collagenase-3 (MMP-13) is a matrix metalloproteinase originally identified in breast carcinomas. Recent studies have revealed that this enzyme is also produced by a variety of malignant tumors including head and neck carcinomas, chondrosarcomas and basal cell carcinomas of the skin. In all cases, the expression of collagenase-3 is associated with aggressive tumors. Different cytokines, growth factors and tumor promoters are able to up-regulate collagenase-3 expression in tumor cells or in stromal cells surrounding epithelial tumor cells. Functional analysis of the collagenase-3 gene promoter has allowed the identification of AP-1 and OSE-2 elements mediating, at least in part, its expression in both normal and pathological conditions.
authors: Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Oviedo, Spain.
authors: M
authors: M
authors: Balbín
authors: A M
authors: AM
authors: Pendás
authors: J A
authors: JA
authors: Uría
authors: M G
authors: MG
authors: Jiménez
authors: J P
authors: JP
authors: Freije
authors: C
authors: C
authors: López-Otín
mesh_terms: D001943:Breast Neoplasms / Q000201:enzymology; D002357:Cartilage Diseases / Q000201:enzymology; D017364:Collagenases / Q000235:genetics*; D015971:Gene Expression Regulation, Enzymologic; D006258:Head and Neck Neoplasms / Q000201:enzymology; D006801:Humans; D053509:Matrix Metalloproteinase 13; D009369:Neoplasms / Q000201:enzymology*
chemical_list: D017364:Collagenases; C507079:MMP13 protein, human; D053509:Matrix Metalloproteinase 13