14-3-3 protein eta chain gene (YWHAH) polymorphism and its genetic association with schizophrenia.
Recent genetic analyses have suggested a linkage between schizophrenia and the chromosomal region 22q12-q13. 14-3-3 protein, abundant in the brain, mediates interactions between diverse molecules of biological activities; its gene was recently mapped to chromosome 22q12.1-q13.1. We therefore investigated allele frequencies of a variable number of tandem repeat (VNTR) in the 5'-noncoding region of the 14-3-3 eta chain gene in controls and schizophrenics. The frequencies of the two-repeat allele were significantly higher (P < 0.05) in the schizophrenics, and particularly in those with onset before age 22 (early-onset schizophrenics, P < 0.02), than in the controls. The odds ratio was significantly increased in the early-onset schizophrenics homozygous for the two-repeat allele (OR = 3.3, 95% CI = 1.1-9.7). The 14-3-3 eta chain gene is a potential susceptibility gene for schizophrenia, and particularly for early-onset schizophrenia.
Toyooka
K
K
National Saigata Hospital, Ogata, Japan.
Muratake
T
T
Tanaka
T
T
Igarashi
S
S
Watanabe
H
H
Takeuchi
H
H
Hayashi
S
S
Maeda
M
M
Takahashi
M
M
Tsuji
S
S
Kumanishi
T
T
Takahashi
Y
Y
D048948:14-3-3 Proteins; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002892:Chromosomes, Human, Pair 22; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011506:Proteins / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D020080:Tandem Repeat Sequences; D014446:Tyrosine 3-Monooxygenase
D048948:14-3-3 Proteins; D005819:Genetic Markers; D011506:Proteins; C482984:YWHAH protein, human; D014446:Tyrosine 3-Monooxygenase