First hydroxamate inhibitors for carboxypeptidase A. N-acyl-N-hydroxy-beta-phenylalanines.
A series of N-acyl-N-hydroxy-beta-Phe were designed, synthesized, and shown to have potent inhibitory activity for carboxypeptidase A (CPA). They are the first examples of CPA inhibitors having a hydroxamate functionality.
Kim
D H
DH
Center for Biofunctional Molecules and Department of Chemistry, Pohang University of Science and Technology, Korea.
Jin
Y
Y
D001407:Bacillus / Q000201:enzymology; D002268:Carboxypeptidases / Q000037:antagonists & inhibitors* / Q000737:chemistry; D043422:Carboxypeptidases A; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D010649:Phenylalanine / Q000138:chemical synthesis* / Q000494:pharmacology; D011487:Protein Conformation; D013329:Structure-Activity Relationship; D013820:Thermolysin / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism
D004791:Enzyme Inhibitors; D010649:Phenylalanine; D002268:Carboxypeptidases; D043422:Carboxypeptidases A; D013820:Thermolysin