title: Fine-needle aspiration cytology of a mediastinal seminoma associated with multilocular thymic cyst.
abstract: Multiloculated thymic cysts are uncommon lesions that can be either acquired or associated with malignancies. This report describes the fine-needle aspiration (FNA) cytology of a mediastinal seminoma with prominent cystic change, confirmed by surgical pathology examination and ancillary studies performed on both the cytology and tissue specimens. The FNA cytology revealed clusters of malignant oval-to-polygonal-shaped cells with large oval nuclei possessing prominent nucleoli set in a pale-to-eosinophilic cytoplasm. These cells were surrounded by a dense lymphoid infiltrate along with a few noncaseating granulomas. The large malignant seminoma cells stained positive for placental alkaline phosphatase (PLAP) and negative for both low molecular and broad-spectrum cytokeratin. The differential diagnosis of malignancies associated with thymic cysts is presented. To the best of our knowledge, this is the first report of aspiration cytology of a mediastinal seminoma associated with a multilocular cyst.
authors: Department of Pathology, Allegheny University of the Health Sciences, Allegheny University Hospital, Pittsburgh, PA 15212-4772, USA. JSilverm@aherf.edu
authors: J F
authors: JF
authors: Silverman
authors: P R
authors: PR
authors: Olson
authors: D J
authors: DJ
authors: Dabbs
authors: R
authors: R
authors: Landreneau
mesh_terms: D001707:Biopsy, Needle; D006801:Humans; D008476:Mediastinal Cyst / Q000150:complications* / Q000473:pathology*; D008479:Mediastinal Neoplasms / Q000150:complications* / Q000473:pathology*; D018239:Seminoma / Q000150:complications* / Q000473:pathology*