title: Calcium transients and neurotransmitter release at an identified synapse.
abstract: It is widely accepted that the modulation of the presynaptic Ca2+ influx is one of the main mechanisms by which neurotransmitter release can be controlled. The well-identified cholinergic synapse in the buccal ganglion of Aplysia has been used to study the modulations that affect presynaptic Ca2+ transients and to relate this to quantal evoked neurotransmitter release. Three types of Ca2+ channel (L, N and P) are present in the presynaptic neurone at this synapse. Influxes of Ca2+ through N- and P-type channels trigger the release of ACh with only N-type Ca2+ channels being regulated by presynaptic neuromodulator receptors. In addition, presynaptic Ca2+ stores, via complex mechanisms of Ca2+ uptake and Ca2+ release, control the Ca2+ concentration that triggers this evoked ACh release.
authors: Laboratoire de Neurobiologie cellulaire et moléculaire C.N.R.S., 91198 Gif sur Yvette cedex, France.
authors: P
authors: P
authors: Fossier
authors: L
authors: L
authors: Tauc
authors: G
authors: G
authors: Baux
mesh_terms: D000109:Acetylcholine / Q000378:metabolism*; D000246:Adenosine Diphosphate Ribose / Q000031:analogs & derivatives / Q000502:physiology; D000818:Animals; D001048:Aplysia / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000145:classification / Q000502:physiology; D020013:Calcium Signaling / Q000502:physiology*; D036563:Cyclic ADP-Ribose; D017952:Ganglia, Invertebrate / Q000502:physiology*; D017136:Ion Transport; D008959:Models, Neurological; D009419:Nerve Tissue Proteins / Q000502:physiology; D015388:Organelles / Q000378:metabolism; D017729:Presynaptic Terminals / Q000502:physiology*
chemical_list: D015220:Calcium Channels; D009419:Nerve Tissue Proteins; D036563:Cyclic ADP-Ribose; D000246:Adenosine Diphosphate Ribose; D000109:Acetylcholine; D002118:Calcium