The sequential analysis of trisomy 12 in B-cell chronic lymphocytic leukaemia.
In this longitudinal study we evaluated the clinical significance of screening for trisomy 12 by fluorescence in situ hybridization (FISH) and correlated these findings with survival, disease progression and need for treatment. Interphase FISH was performed on 85 patients in 1993/94 and repeated on 41 patients in 1996/97. Over the 4-year period there was no significant change in the percentage of trisomic cells, even in patients with disease progression. Overall survival and requirement for treatment were similar for patients with and without FISH-defined trisomy 12.
Auer
R L
RL
Department of Haematology, Birmingham Heartlands Hospital, Bordesley Green East.
Bienz
N
N
Neilson
J
J
Cai
M
M
Waters
J J
JJ
Milligan
D W
DW
Fegan
C D
CD
D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D005500:Follow-Up Studies; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D008137:Longitudinal Studies; D014314:Trisomy