Bidirectional signaling between the cytoskeleton and integrins.
Clustering of integrins into focal adhesions and focal complexes is regulated by the actin cytoskeleton. In turn, actin dynamics are governed by Rho family GTPases. Integrin-mediated adhesion activates these GTPases, triggering assembly of filopodia, lamellipodia and stress fibers. In the past few years, signaling pathways have begun to be identified that promote focal adhesion disassembly and integrin dispersal. Many of these pathways result in decreased myosin-mediated cell contractility.
Schoenwaelder
S M
SM
The Department of Cell Biology and Anatomy, 108 Taylor Hall, CB#7090, University of North Carolina, Chapel Hill, NC 27599, USA. drsms@med.unc.edu
Burridge
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D000199:Actins / Q000502:physiology; D000818:Animals; D002448:Cell Adhesion; D018797:Cell Cycle Proteins / Q000502:physiology; D000242:Cyclic AMP / Q000502:physiology; D017868:Cyclic AMP-Dependent Protein Kinases / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology*; D016326:Extracellular Matrix Proteins / Q000502:physiology; D020558:GTP Phosphohydrolases / Q000502:physiology; D019204:GTP-Binding Proteins / Q000502:physiology; D006801:Humans; D016023:Integrins / Q000502:physiology*; D007382:Intermediate Filaments / Q000502:physiology; D008870:Microtubules / Q000502:physiology; D008954:Models, Biological; D015388:Organelles / Q000502:physiology / Q000648:ultrastructure; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D017027:Protein Tyrosine Phosphatases / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D020744:rac GTP-Binding Proteins; D020742:rhoA GTP-Binding Protein
D000199:Actins; D018797:Cell Cycle Proteins; D016326:Extracellular Matrix Proteins; D016023:Integrins; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases; D017027:Protein Tyrosine Phosphatases; D020558:GTP Phosphohydrolases; D019204:GTP-Binding Proteins; D020744:rac GTP-Binding Proteins; D020742:rhoA GTP-Binding Protein