title: Lower urinary tract dysfunction and disability status in patients with multiple sclerosis.
abstract: OBJECTIVE
  To investigate the correlation between neurologic and urologic status in patients with multiple sclerosis (MS).
  
  
  METHODS
  Between January 1993 and December 1995, 116 patients with MS symptoms were fully assessed neurologically and urologically with urodynamic studies.
  
  
  RESULTS
  Urodynamic abnormalities were detected in 104 patients (89.6%). Several significant relationships between urinary tract findings and neurologic dysfunction were: (1) the relation between voiding disorder as the presenting symptom of the disease and a higher severity of bladder dysfunction; (2) the relation between reduced bladder sensation and longer duration of voiding disorders, lower detrusor uninhibited contractions threshold, and lower bladder capacity; and (3) the relation between voiding disorders and cerebellar system score. Finally, a significant inverse relationship was found between detrusor hypocontractility and neurologic status (from the Expanded Disability Status Scale, pyramidal system score, and Barthel Index).
  
  
  CONCLUSIONS
  In this series a high incidence of patients reported voiding disorder as the presenting symptom of MS. These patients also showed a higher severity of urodynamic disorders. They should be rigorously followed up. Furthermore, our data suggest that although the most common cause of altered bladder control in MS is spinal cord pathology, involvement of cortical centers and/or peripheral neuronal lesions may occur.
authors: S. Lucia IRCCS Rehabilitation Hospital, Rome, Italy.
authors: A
authors: A
authors: Giannantoni
authors: G
authors: G
authors: Scivoletto
authors: S M
authors: SM
authors: Di Stasi
authors: M G
authors: MG
authors: Grasso
authors: E
authors: E
authors: Finazzi Agrò
authors: G
authors: G
authors: Collura
authors: G
authors: G
authors: Vespasiani
mesh_terms: D000328:Adult; D000368:Aged; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000503:physiopathology / Q000534:rehabilitation; D009460:Neurologic Examination; D011379:Prognosis; D001750:Urinary Bladder, Neurogenic / Q000175:diagnosis* / Q000503:physiopathology / Q000534:rehabilitation; D014563:Urodynamics / Q000502:physiology