title: Effect of radiotherapy on brain glucose metabolism in patients operated on for low grade astrocytoma.
abstract: OBJECTIVE
  To assess the effect of postoperative radiotherapy on brain glucose metabolism (CMRGlu) of operated patients with low grade astrocytomas.
  
  
  METHODS
  PET and 18F-fluorodeoxyglucose was used to measure absolute CMRGlu in patients with fibrillary astrocytoma (WHO II) of the frontal lobe, who did (n=7) or did not (n=12) receive radiotherapy subsequent to first debulking tumour resection. In addition, statistical parametric mapping (SPM95) was applied to assess the pattern of relative CMRGlu associated with the frontal tumour. Data were compared with 12 healthy controls.
  
  
  RESULTS
  A global reduction of absolute CMRGlu was found when either patients with or without radiotherapy were compared with controls (ROI analysis). Brain areas of relative CMRGlu reduction were found in the brain ipsilateral and contralateral to the tumour, comparing both patient groups with controls by SPM ("tumour diaschisis effect"). Superimposed, absolute CMRGlu in the contralateral frontal, parietal, occipital cortex as well as in the white matter was on average 17% lower in patients receiving radiotherapy than in patients who did not.
  
  
  CONCLUSIONS
  The data discriminate a tumour effect from a radiotherapy effect, and support the view of adverse effects of radiotherapy on brain not directly involved by tumour.
authors: PET Program, Paul Scherrer Institute, CH-5232 Villigen, Switzerland. Matthias.Bruehlmeier@psi.ch
authors: M
authors: M
authors: Bruehlmeier
authors: U
authors: U
authors: Roelcke
authors: B
authors: B
authors: Amsler
authors: K H
authors: KH
authors: Schubert
authors: O
authors: O
authors: Hausmann
authors: K
authors: K
authors: von Ammon
authors: E W
authors: EW
authors: Radü
authors: O
authors: O
authors: Gratzl
authors: C
authors: C
authors: Landmann
authors: K L
authors: KL
authors: Leenders
mesh_terms: D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000378:metabolism* / Q000503:physiopathology / Q000532:radiotherapy*; D001786:Blood Glucose / Q000378:metabolism*; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D001931:Brain Mapping; D001932:Brain Neoplasms / Q000378:metabolism* / Q000503:physiopathology / Q000532:radiotherapy*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D014055:Tomography, Emission-Computed
chemical_list: D001786:Blood Glucose; D019788:Fluorodeoxyglucose F18