In vivo performance of wax matrix granules prepared by a twin-screw compounding extruder.
The in vivo performance of wax matrix granules (WMGs) prepared by a twin-screw compounding extruder was evaluated in fasted beagle dogs. In vitro dissolution behavior of the model drug, diclofenac sodium (DS), from WMGs was strongly influenced by pH in a dissolution medium due to its solubility (DS is soluble in pH 6.8 and insoluble in pH 1.2 and 4.0) and was independent of paddle rotation rate (50, 100, and 200 rpm) of the dissolution apparatus. Pharmacokinetics parameters such as mean residence time (MRT) showed a sustained action of WMGs in beagle dogs; however, the transit time of WMGs in the small intestine is found to control total drug absorption. Furthermore, the values of the area under the curve (AUC) of the plasma concentration-time curve and the maximum concentration Cmax significantly decreased with decreases in hydroxypropylcellulose (HPC) content in WMGs. Good correlation between one in vitro dissolution parameter (mean dissolution time, MDT) and two in vivo parameters (AUC12 and MRT) suggested that it would be possible to design WMGs with a desired in vivo performance by controlling HPC content.
Miyagawa
Y
Y
Central Research Laboratories, Zeria Pharmaceutical Company, Ltd., Osato-gun, Japan.
Sato
H
H
Okabe
T
T
Nishiyama
T
T
Miyajima
M
M
Sunada
H
H
D000818:Animals; D001682:Biological Availability; D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D004008:Diclofenac / Q000097:blood*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004339:Drug Compounding; D004347:Drug Interactions; D005772:Gastrointestinal Transit / Q000502:physiology*; D006863:Hydrogen-Ion Concentration; D008297:Male; D012995:Solubility; D014885:Waxes / Q000378:metabolism*
D014885:Waxes; D004008:Diclofenac; D002482:Cellulose; C008079:hydroxypropylcellulose