New reciprocal translocation t(5;10)(q33;q22) associated with atypical chronic myeloid leukemia.
We report a new chromosomal reciprocal translocation t(5;10)(q33;q22) in a 49-year-old man with atypical chronic myeloid leukemia (a-CML) and history of occupational exposure to petroleum products including benzene and other hydrocarbons. The t(5;10) (q33;q22) was found in 94% and 84% of metaphases in peripheral blood and bone marrow cells, respectively. Cytogenetic analysis of single colonies derived from granulocyte-macrophage (CFU-GM), and erythroid (BFU-E) hematopoietic progenitors showed that 88% and 40% of CFU-GM and BFU-E, respectively, had the t(5;10)(q33;q22). In contrast, peripheral blood T-lymphocytes, and cutaneous fibroblasts had normal 46,XY karyotype. Molecular analysis of the t(5;10)(q33;q22) translocation breakpoint is currently underway in order to identify genes located in this region which might provide insights into the pathogenesis of atypical myeloproliferative disorders.
Siena
S
S
Divisione Oncologia Medica Falck, Piazza Ospedale Maggiore 3, 20162 Milan, Italy. salsiena@tin.it
Sammarelli
G
G
Grimoldi
M G
MG
Schiavo
R
R
Nozza
A
A
Roncalli
M
M
Mecucci
C
C
Santoro
A
A
Carlo-Stella
C
C
D002879:Chromosomes, Human, Pair 10; D002895:Chromosomes, Human, Pair 5; D006801:Humans; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic