[Molecular biology and clinical diabetology].
Recent advancement of molecular biology highlighted three areas of basic research which may be important for clinical diabetology. One is the understanding of mechanisms of differentiation in pancreatic beta-cells and adipocytes. The second is the development of methods of tissue-specific knock-out mouse. This approach revealed that muscle may not be important for insulin-dependent glucose disposal in vivo. The third is the advancement of genetics which enabled to clone a major susceptibililly gene for type 2 diabetes mellitus (NIDDM1). These progress may bring new therapies for clinical diabetology.
Kasuga
M
M
Second Department of Internal Medicine, Kobe University Medical School.
D000818:Animals; D017209:Apoptosis; D003921:Diabetes Mellitus, Experimental / Q000209:etiology; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005821:Genetic Techniques; D007333:Insulin Resistance; D007515:Islets of Langerhans / Q000166:cytology; D051379:Mice; D018345:Mice, Knockout