title: Potent and selective bicyclic lactam inhibitors of thrombin: Part 3: P1' modifications.
abstract: The synthesis and antithrombotic activity of a series of nonpeptide bicyclic thrombin inhibitors are described. We have explored the SAR around the P1' site. Modification of the P1' site has been found to affect potency and selectivity.
authors: Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, MI 48105, USA.
authors: J S
authors: JS
authors: Plummer
authors: K A
authors: KA
authors: Berryman
authors: C
authors: C
authors: Cai
authors: W L
authors: WL
authors: Cody
authors: J
authors: J
authors: DiMaio
authors: A M
authors: AM
authors: Doherty
authors: S
authors: S
authors: Eaton
authors: J J
authors: JJ
authors: Edmunds
authors: D R
authors: DR
authors: Holland
authors: D
authors: D
authors: Lafleur
authors: S
authors: S
authors: Levesque
authors: L S
authors: LS
authors: Narasimhan
authors: J R
authors: JR
authors: Rubin
authors: S T
authors: ST
authors: Rapundalo
authors: M A
authors: MA
authors: Siddiqui
authors: A
authors: A
authors: Susser
authors: Y
authors: Y
authors: St-Denis
authors: P
authors: P
authors: Winocour
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006571:Heterocyclic Compounds / Q000737:chemistry; D020128:Inhibitory Concentration 50; D007700:Kinetics; D007769:Lactams / Q000494:pharmacology*; D008956:Models, Chemical; D008958:Models, Molecular; D051381:Rats; D013917:Thrombin / Q000037:antagonists & inhibitors*; D013927:Thrombosis / Q000188:drug therapy
chemical_list: D006571:Heterocyclic Compounds; D007769:Lactams; D013917:Thrombin