[The effect of contrast agents on latex phagocytosis by mouse neutrophils].
The authors studied the effect of radiopaque agents (ROA):triombrast, omnipak, and ultravist and that of magnetoresonant contrast agents: omniscan and magnevist in concentration ranges (10(-4)-10(-2) M) on the phagocytizing activity of mouse neutrophils. All contrast agents inhibitors absorption of latex fragments by the neutrophils. A strong correlation was revealed between the osmotic activity of the radiopaque agents under study and the degree of suppression of neutrophil phagocytizing activity.
Temnov
A A
AA
Department of Molecular Pharmacology and Radiobiology MBF, Russian State Medical University, Moscow, Russia.
Shimanovskiĭ
N L
NL
D000818:Animals; D002478:Cells, Cultured; D003287:Contrast Media / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D008863:Microspheres; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology; D010529:Peritoneal Cavity / Q000166:cytology; D010587:Phagocytosis / Q000187:drug effects*
D003287:Contrast Media