[The effect of the zinc-containing preparation Oxyrich in the treatment of chronic saturnism (preliminary results)].
Under indoor conditions the effect of the Bulgarian zinc-containing preparation Oxyrich was studied in the treatment of 12 workers (males) with chronic saturnism. The preparation was orally administered in a dose of 150 mg (0.45 mmol Zn++) daily for 10 days in three equal receivings, after which three day antidotal therapy with CaNa2 EDTA was carried out according to the classic schedule. The complex investigation of the workers besides the clinical exmination included some key indices of the porphirine metabolism (5-ALK-D, 5-ALK, free protoporphirine in the red bolld cells), as well as the content of zinc and lead in the blood and their excretion with the urine prior and post the administration of Oxyrich and CaNa2 EDTA. The results of the carried out study revealed that the therapy with Oxyrich demonstrated a tendency to normalization of the activity of 5-ALK-D and decrease of the elimination of 5-ALK. This gave grounds for further study with higher doses of Oxyrich, as well as enlargement of the spectrum of the indices of the porphirine metabolism.
Pavlova
S
S
Petkova
V
V
Nachev
Ch
Ch
Georgieva
D
D
Kerimova
M
M
Khadzhieva
I
I
D000328:Adult; D000931:Antidotes / Q000627:therapeutic use*; D002614:Chelating Agents / Q000627:therapeutic use; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D004492:Edetic Acid / Q000627:therapeutic use; D006801:Humans; D007854:Lead; D007855:Lead Poisoning / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D013997:Time Factors; D015032:Zinc / Q000627:therapeutic use*
D000931:Antidotes; D002614:Chelating Agents; D007854:Lead; D004492:Edetic Acid; D015032:Zinc