Developmental neurobiology: Alternative ends for a familiar story?
Somatic DNA recombination is essential for production of functional antigen receptor genes of T and B lymphocytes, but it is thought to be unique to the immune system. Recent studies have now shown that recombination-related genes are also necessary for normal neuronal development.
Chun
J
J
Department of Pharmacology, Neurosciences Program, Biomedical Sciences Program, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0636, USA. jchun@ucsd.edu
Schatz
D G
DG
D000818:Animals; D002490:Central Nervous System / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D000072481:DNA Ligase ATP; D011088:DNA Ligases / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D015321:Gene Rearrangement / Q000235:genetics; D018398:Homeodomain Proteins / Q000235:genetics; D007107:Immune System / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D016131:Lymphocyte Subsets / Q000166:cytology / Q000378:metabolism; D009474:Neurons / Q000166:cytology / Q000378:metabolism
D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; C101467:XRCC4 protein, human; C064658:RAG-1 protein; D011088:DNA Ligases; D000072481:DNA Ligase ATP