Improvement of blood compatibility on cellulose hemodialysis membrane: IV. Phospholipid polymer bonded to the membrane surface.
To improve the surface blood compatibility on a cellulose hemodialysis membrane, 2-methacryloyloxyethyl phosphorylcholine (MPC) polymers with a phospholipid polar group were immobilized on the surface through covalent bonding. The MPC polymers had a carboxylic group, which can react with hydroxyl groups on the cellulose membrane, and were synthesized by conventional radical polymerization. The reaction between the MPC polymers and the cellulose membrane was carried out in a heterogeneous system using a condensation reagent. Surface analysis of the modified membrane by X-ray photoelectron spectroscopy revealed the immobilization of the MPC polymer on the surface. The mechanical strength and permeability for a solute of the membrane did not change even after the modification. The modified cellulose membrane was blood-compatible, as determined by the prevention of adhesion, deformation, and aggregation of platelets after contact with platelet-rich plasma. Based on these results, it is concluded that the MPC polymers may be a useful material for improving the blood compatibility of cellulose hemodialysis membranes.
Ishihara
K
K
Institute for Medical and Dental Engineering, Tokyo Medical and Dental University, Japan.
Shinozuka
T
T
Hanazaki
Y
Y
Iwasaki
Y
Y
Nakabayashi
N
N
D000327:Adsorption; D000818:Animals; D001672:Biocompatible Materials; D001798:Blood Proteins / Q000737:chemistry; D002482:Cellulose / Q000737:chemistry; D003165:Complement System Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D006801:Humans; D008422:Materials Testing; D008567:Membranes, Artificial; D008689:Methacrylates / Q000737:chemistry*; D010539:Permeability; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000737:chemistry; D010973:Platelet Adhesiveness; D011109:Polymethacrylic Acids; D011817:Rabbits; D006435:Renal Dialysis / Q000295:instrumentation*; D013499:Surface Properties
D001672:Biocompatible Materials; D001798:Blood Proteins; D008567:Membranes, Artificial; D008689:Methacrylates; D011109:Polymethacrylic Acids; C115766:poly(2-methacryloyloxyethyl-phosphorylcholine); D010767:Phosphorylcholine; D002482:Cellulose; D003165:Complement System Proteins