Study of the antitumor effect of Ukrain: the role of macrophage secretion of alpha-1-proteinase inhibitor.
The positive antitumor effect of Ukrain was shown following i.m. injection of a mixture of this drug with Krebs-2 carcinoma cells to CBA mice. The protective effect was suggested to be a result of the influx of macrophages into the site of Ukrain injection. In contrast, contralateral administration of Ukrain had a negative effect, confirming our hypothesis that Ukrain attracts cytolytic macrophages. In the murine HA-1 hepatoma model treated by single or repeated Ukrain injections, a moderate positive effect of Ukrain was related to increased macrophage (alpha-1-proteinase inhibitor (PI) secretion. The role of tumor cells and macrophages in the secretion of PI (the main inhibitor of serine proteinases) during tumor development is discussed.
Korolenko
T A
TA
Institute of Physiology, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia.
Kaledin
V I
VI
Svechnikova
I G
IG
Li
X V
XV
Stashko
J F
JF
Ilnitskaya
S I
SI
Nikolin
V P
VP
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001600:Berberine Alkaloids; D008264:Macrophages / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010617:Phenanthridines; D000515:alpha 1-Antitrypsin / Q000502:physiology*
D000470:Alkaloids; D000970:Antineoplastic Agents; D001600:Berberine Alkaloids; D010617:Phenanthridines; D000515:alpha 1-Antitrypsin; C060921:ukrain