Increase in interleukin-6 and fibrinogen in peripheral blood after swine dust inhalation.
OBJECTIVE
The inhalation of dust from swine confinement buildings causes inflammatory responses in the airways with a rise of interleukin-6 (IL-6). The purpose of this study was to confirm the increase in serum IL-6 after inhalation of swine dust and investigate a possible increase in plasma fibrinogen.


METHODS
Eight healthy nonsmoking volunteers inhaled dust for 4 hours inside a swine confinement building. Inhalable dust and endotoxin were sampled. The concentrations of IL-6 and fibrinogen were determined in serum and plasma.


RESULTS
The study showed a clear increase in the concentrations of IL-6 and fibrinogen after exposure.


CONCLUSIONS
As fibrinogen is an important risk factor for ischemic heart disease, the increased concentration of fibrinogen among persons exposed to swine dust may increase the risk for this disease.
Sjörgren
B
B
Department for Work and Health, Swedish National Institute for Working Life, Solna. Bengt.Sjogren@niwl.se
Wang
Z
Z
Larsson
B M
BM
Larsson
K
K
Larsson
P H
PH
Westerholm
P
P
D000328:Adult; D000818:Animals; D004391:Dust / Q000009:adverse effects*; D004731:Endotoxins / Q000009:adverse effects*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D019570:Inhalation Exposure / Q000009:adverse effects; D015850:Interleukin-6 / Q000097:blood*; D016014:Linear Models; D008297:Male; D013552:Swine
D004391:Dust; D004731:Endotoxins; D015850:Interleukin-6; D005340:Fibrinogen