title: Formulation and evaluation of controlled release Eudragit buccal patches.
abstract: Controlled release buccal patches were fabricated using Eudragit NE40D and studied. Various bioadhesive polymers, namely hydroxypropylmethyl cellulose, sodium carboxymethyl cellulose and Carbopol of different grades, were incorporated into the patches, to modify their bioadhesive properties as well as the rate of drug release, using metoprolol tartrate as the model drug. The in-vitro drug release was determined using the USP 23 dissolution test apparatus 5 with slight modification, while the bioadhesive properties were evaluated using texture analyzer equipment with chicken pouch as the model tissue. The incorporation of hydrophilic polymers was found to affect the drug release as well as enhance the bioadhesiveness. Although high viscosity polymers can enhance the bioadhesiveness of the patches, they also tend to cause non-homogeneous distribution of the polymers and drug, resulting in non-predictable drug-release rates. Of the various bioadhesive polymers studied, Cekol 700 appeared to be most satisfactory in terms of modifying the drug release and enhancement of the bioadhesive properties.
authors: Department of Pharmaceutics, School of Pharmaceutical Sciences, University of Science Malaysia, Penang, Malaysia.
authors: C F
authors: CF
authors: Wong
authors: K H
authors: KH
authors: Yuen
authors: K K
authors: KK
authors: Peh
mesh_terms: D000180:Acrylic Resins; D000268:Adhesiveness; D000287:Administration, Topical; D000818:Animals; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry; D002645:Chickens; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics*; D016503:Drug Delivery Systems; D015195:Drug Design; D066298:In Vitro Techniques; D007785:Lactose / Q000031:analogs & derivatives / Q000737:chemistry; D008747:Methylcellulose / Q000031:analogs & derivatives / Q000737:chemistry; D008954:Models, Biological; D009061:Mouth Mucosa / Q000378:metabolism*; D010078:Oxazines; D011108:Polymers / Q000737:chemistry*; D011145:Polyvinyls / Q000737:chemistry; D012995:Solubility; D014783:Viscosity
chemical_list: D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D010078:Oxazines; D011108:Polymers; D011145:Polyvinyls; C006912:carboxypolymethylene; D008747:Methylcellulose; C071191:MK 458; D007785:Lactose; D002266:Carboxymethylcellulose Sodium