Experimental studies in distal urinary acidification: bringing the bedside to the bench.
The renal tubular acidosis syndromes are nonuremic defects of urinary acidification. They are characterized by a normal anion gap and hyperchloremic metabolic acidosis; plasma potassium may be normal, low, or high, depending on the syndrome present. As new technologies have been applied to biology, we now better understand the basic lesions of these important syndromes.
Sabatini
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Department of Physiology, Texas Tech University Health Sciences Center, Lubbock, USA.
D000141:Acidosis, Renal Tubular / Q000503:physiopathology; D000818:Animals; D017506:H(+)-K(+)-Exchanging ATPase / Q000378:metabolism; D006801:Humans; D007686:Kidney Tubules, Distal / Q000503:physiopathology; D011188:Potassium / Q000097:blood; D017494:Proton Pumps / Q000378:metabolism; D006180:Proton-Translocating ATPases / Q000378:metabolism
D017494:Proton Pumps; D017506:H(+)-K(+)-Exchanging ATPase; D006180:Proton-Translocating ATPases; D011188:Potassium