Epstein-Barr virus-associated leiomyosarcoma of the thyroid in a child with congenital immunodeficiency: a case report.
We report an unusual case of multifocal leiomyosarcoma involving the thyroid gland, liver, and right lung in a child with congenital immunodeficiency disease. The smooth muscle nature of these neoplasms was confirmed by immunohistochemistry and electron microscopic studies. In situ hybridization showed large amounts of Epstein-Barr virus messenger RNA within the tumor cells. Although Epstein-Barr virus-associated smooth muscle tumors have been reported in children with AIDS and after organ transplantation, we are unaware of any case report in congenital immunodeficiency disease.
Tulbah
A
A
Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Al-Dayel
F
F
Fawaz
I
I
Rosai
J
J
D002675:Child, Preschool; D006566:Herpesviridae Infections / Q000473:pathology / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D016867:Immunocompromised Host; D007153:Immunologic Deficiency Syndromes / Q000151:congenital*; D017403:In Situ Hybridization; D007890:Leiomyosarcoma / Q000276:immunology / Q000556:secondary / Q000601:surgery / Q000821:virology*; D008113:Liver Neoplasms / Q000821:virology; D008175:Lung Neoplasms / Q000821:virology; D008297:Male; D012367:RNA, Viral / Q000032:analysis; D013601:T-Lymphocytes / Q000473:pathology; D013964:Thyroid Neoplasms / Q000276:immunology / Q000473:pathology / Q000601:surgery / Q000821:virology*; D014412:Tumor Virus Infections / Q000473:pathology / Q000821:virology*
D012367:RNA, Viral