The role of calcium in apoptosis.
In this chapter various aspects of apoptosis or programmed cell death (PCD) influenced by calcium as a mediator of signal transduction have been reviewed. Attention has been focused on recently described calcium-binding proteins such as ALG-2 or on a new calcium/calmodulin-dependent kinase, the death associated protein kinase or DAP-kinase. Both play a central role in apoptotic processes. Calcineurin, which normally is involved in the regulation of T-cell proliferation, is reported to interact with the apoptosis protection protein bcl-2. Its possible involvement in the decision process whether T-cell activation leads to proliferation or apoptosis is discussed.
Krebs
J
J
Institute of Biochemistry, Swiss Federal Institute of Technology, Zurich, Switzerland. krebs@bc.biol.ethz.ch
D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D051017:Apoptosis Regulatory Proteins; D002118:Calcium / Q000502:physiology*; D002135:Calcium-Binding Proteins / Q000737:chemistry* / Q000378:metabolism*; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000378:metabolism; D064550:Death-Associated Protein Kinases; D005938:Glucocorticoids / Q000502:physiology; D006801:Humans; D008213:Lymphocyte Activation; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction / Q000502:physiology; D013601:T-Lymphocytes / Q000502:physiology
D051017:Apoptosis Regulatory Proteins; D002135:Calcium-Binding Proteins; D005938:Glucocorticoids; C097753:PDCD6 protein, human; D064550:Death-Associated Protein Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D002118:Calcium