title: Force-current relationships in intraneural stimulation: role of extraneural medium and motor fibre clustering.
abstract: Animal experiments and model simulations of monopolar, intrafascicular nerve stimulation are presented to study force-current relationships (recruitment curves). The conductivity of the extraneural medium is of prime importance to the resulting recruitment cures: an insulating extraneural medium generally leads to steeper curves with lower threshold currents than a well-conducting extraneural medium. Extensive statistical comparison of experimental and model results suggests the occurrence of clustering of alpha-motoneurons within the fascicle, manifesting itself mainly by an increased spread in threshold currents, as opposed to the situation where the fibres are distributed uniformly throughout the entire fascicle.
authors: Department of Electrical Engineering, University of Twente, Enschede, The Netherlands.
authors: T A
authors: TA
authors: Frieswijk
authors: J P
authors: JP
authors: Smit
authors: W L
authors: WL
authors: Rutten
authors: H B
authors: HB
authors: Boom
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D008959:Models, Neurological; D009412:Nerve Fibers / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D011999:Recruitment, Neurophysiological / Q000502:physiology*