Removal of strontium by the chelating agent acetylamino propylidene diphosphonic acid in rats.
Studies of the effects of the chelating agent, calcium acetylamino propylidene diphosphonic acid (Ca-APDA), on the removal of radioactive strontium with two administration modalities were carried out in rats. The parenteral (intraperitoneal) administration of 150, 300, or 600 mg kg(-1) Ca-APDA was carried out for 3 d, 10 min after exposure of the animals to the strontium injection. On the first day post-treatment, the retention of strontium in the whole body decreased to 90.1%, 83.9%, and 35.1% that of the control level, respectively. The strontium deposited in femur of 600 mg kg(-1) Ca-APDA group was lowered to 28.4% of the control value. A single oral dose of 600 mg kg(-1) Ca-APDA administered simultaneously with, or 10 min after, oral administration of strontium, radionuclide retention in the whole body was reduced after 1 d to 42.9% and 31.9% of the control, respectively; meanwhile the strontium deposited in the femur was reduced to 16.9% and 29.3% of the control. In conclusion, the results indicate the efficacy of the new agent, Ca-APDA, to remove radioactive strontium from the body, or to inhibit the strontium intestinal absorption, in radio-strontium contaminated individuals.
Fukuda
S
S
Division of Radiotoxicology and Protection, National Institute of Radiological Sciences, Chiba, Japan.
Iida
H
H
Yan
Y
Y
Xie
Y
Y
Chen
W
W
D000284:Administration, Oral; D000818:Animals; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism; D002614:Chelating Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D004164:Diphosphonates / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D005243:Feces / Q000737:chemistry; D007274:Injections, Intraperitoneal; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013324:Strontium / Q000378:metabolism* / Q000652:urine; D013326:Strontium Radioisotopes
D002614:Chelating Agents; D004164:Diphosphonates; D013326:Strontium Radioisotopes; C118445:acetylamino propylidene diphosphonic acid; D013324:Strontium