Frequency of CD43 expression in non-Hodgkin lymphoma. A survey of 742 cases and further characterization of rare CD43+ follicular lymphomas.
CD43 expression on B cells is an immunophenotypic feature suggestive of malignancy. In the light of its diagnostic importance, we performed a comprehensive survey of CD43 expression in various types of non-Hodgkin lymphoma (NHL) and determined the frequency of its expression in routinely fixed paraffin-embedded tissues. Tissue sections in 742 cases of NHL, pretreated by the heat-induced epitope retrieval technique, were immunostained using an anti-CD43 antibody. Three categories of CD43 positivity were found: (1) more than 90% of T-cell lymphoma, mantle cell lymphoma, B-cell small lymphocytic lymphoma, and Burkitt lymphoma cases were positive; (2) 20% to 40% of nodal and extranodal marginal zone lymphoma (MZL), diffuse large B-cell lymphoma, Burkitt-like B-cell lymphoma, and lymphoplasmacytoid lymphoma cases were positive; and (3) 0% to 6% of primary splenic MZL and various types of follicular lymphoma cases were positive. Most CD43+ follicular lymphomas were predominantly large cell type with focally diffuse areas; their follicular center cell origin in 4 of 8 cases was supported by the presence of CD10 immunoreactivity and/or t(14;18) fusion gene product. CD43 is frequently detectable in a subset of B-NHL, and, thus, it seems to be a highly sensitive marker for these tumors. CD43 also may be a useful marker for classifying B-cell NHLs by virtue of its differential expression in these tumors.
Lai
R
R
Division of Pathology, City of Hope National Medical Center, Duarte, California 91010, USA.
Weiss
L M
LM
Chang
K L
KL
Arber
D A
DA
D000328:Adult; D015703:Antigens, CD; D001402:B-Lymphocytes / Q000276:immunology*; D014408:Biomarkers, Tumor / Q000032:analysis; D002051:Burkitt Lymphoma / Q000276:immunology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology; D051917:Leukosialin; D016393:Lymphoma, B-Cell / Q000276:immunology; D008224:Lymphoma, Follicular / Q000276:immunology*; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology*; D016399:Lymphoma, T-Cell / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012795:Sialoglycoproteins / Q000032:analysis*; D016610:Tissue Embedding
D015703:Antigens, CD; D014408:Biomarkers, Tumor; D051917:Leukosialin; C465014:SPN protein, human; D012795:Sialoglycoproteins