Applications of telomerase research in the fight against cancer.
Telomerase, an enzyme that confers immortality upon cells and that is active in the majority of human tumors, has emerged as a powerful new marker and potential prognostic indicator and therapeutic target for cancer. Furthermore, investigations into the biology of telomerase have revealed important clues into the causes of cell death and have made progress toward answering one of the most important questions of cancer research - what gives a tumor cell an advantage over normal cells? In this article, we present the current state of telomerase research and critically assess both its potential and the pitfalls of its application in cancer diagnosis and treatment.
McKenzie
K E
KE
Breast Cancer Research Program, University of California, Oakland, CA, USA.
Umbricht
C B
CB
Sukumar
S
S
D004789:Enzyme Activation; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis / Q000201:enzymology* / Q000628:therapy; D012106:Research; D019098:Telomerase / Q000378:metabolism* / Q000627:therapeutic use; D016615:Telomere / Q000378:metabolism
D019098:Telomerase