Activity-dependent Nurr1 and NGFI-B gene expression in adult mouse olfactory bulb.
Previous studies showed that Nurr1 is essential to development of the dopamine phenotype in midbrain, but not for dopaminergic neurons intrinsic to the olfactory bulb (OB). The current study investigated the distribution of Nurr1 and NGFI-B as well as a role for both of these related orphan receptors in tyrosine hydroxylase (TH) expression in OB. Both NGFI-B and Nurr1 mRNAs were found in the glomerular and granule cell layers of OB. In contrast, only Nurr1 occurred in midbrain dopamine neurons. Both receptors as well as TH exhibited down-regulation in OB in response to odor deprivation produced by unilateral naris closure. These data suggest that in OB, both Nurr1 and NGFI-B may participate in development and regulation of the dopamine phenotype.
Liu
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Laboratory of Molecular Neurobiology, Cornell University Medical College at The Burke Medical Research Institute, White Plains, NY 10605, USA.
Baker
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D000818:Animals; D004268:DNA-Binding Proteins / Q000096:biosynthesis*; D015870:Gene Expression / Q000502:physiology*; D017403:In Situ Hybridization; D008297:Male; D051379:Mice; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000502:physiology*; D057105:Nuclear Receptor Subfamily 4, Group A, Member 1; D057126:Nuclear Receptor Subfamily 4, Group A, Member 2; D009812:Odorants; D009830:Olfactory Bulb / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear; D011987:Receptors, Steroid; D012683:Sensory Deprivation / Q000502:physiology; D012903:Smell / Q000502:physiology; D014157:Transcription Factors / Q000096:biosynthesis* / Q000235:genetics* / Q000502:physiology*; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics / Q000378:metabolism
D004268:DNA-Binding Proteins; D009419:Nerve Tissue Proteins; C539818:Nr4a1 protein, mouse; C539883:Nr4a2 protein, mouse; D057105:Nuclear Receptor Subfamily 4, Group A, Member 1; D057126:Nuclear Receptor Subfamily 4, Group A, Member 2; D018160:Receptors, Cytoplasmic and Nuclear; D011987:Receptors, Steroid; D014157:Transcription Factors; D014446:Tyrosine 3-Monooxygenase