[The effect of selective serotonin administration into different portions of the coronary vascular bed on the retrograde (collateral) coronary blood flow in myocardial ischemia in dogs].
The purpose of the present investigation was to determine the action of intra-coronary infusion of serotonin on collateral blood flow in dog heart. Intra-coronary injection of serotonin elicited a cardiogenic hypertensive chemoreflex and transient but marked reductions of collateral blood flow. The cardiac and circulatory effects of the hypertensive cardiogenic chemoreflex and reductions of collateral blood flow abolished by sectioning of the cervical vagi. These data indicate that serotonin act on blood flow in collateral-dependent tissue of ischemic dog heart.
Azarov
V I
VI
A. A. Bogomoletz Institute of Physiology, NAS, Ukraine.
Hrabovs'kyĭ
L O
LO
Moĭbenko
O O
OO
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002406:Catheterization, Peripheral; D003097:Collateral Circulation / Q000187:drug effects* / Q000502:physiology; D003326:Coronary Circulation / Q000187:drug effects* / Q000502:physiology; D003331:Coronary Vessels / Q000187:drug effects* / Q000503:physiopathology; D004285:Dogs; D007269:Injections, Intra-Arterial; D017202:Myocardial Ischemia / Q000503:physiopathology*; D012701:Serotonin / Q000008:administration & dosage*; D013997:Time Factors
D012701:Serotonin