title: Neuropeptide Y: a key molecule in anorexia and cachexia in wasting disorders?
abstract: Anorexia and body weight loss are characteristic of many diseases, including cancer and AIDS. Recent studies indicate that inflammatory cytokines, such as interleukin 1, the interleukin 6 subfamily and tumor necrosis factor, induce anorexia and cachexia by inhibiting the normal adaptive feeding response to energy deficits. Here, I discuss the evidence for and against a central role for neuropeptide Y and leptin in anorexia and cachexia.
authors: Second Dept of Internal Medicine, Kobe University School of Medicine, Japan. inui@med.kobe-u.ac.jp
authors: A
authors: A
authors: Inui
mesh_terms: D000818:Animals; D000855:Anorexia / Q000209:etiology*; D001066:Appetite; D002100:Cachexia / Q000209:etiology*; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism; D009478:Neuropeptide Y / Q000502:physiology*; D013577:Syndrome; D019282:Wasting Syndrome / Q000209:etiology*
chemical_list: D016207:Cytokines; D009478:Neuropeptide Y