Antihepatotoxic activity of Swertia chirata on carbon tetrachloride induced hepatotoxicity in rats.
The methanol extract of Swertia chirata was evaluated for antihepatotoxic activity against carbon tetrachloride induced liver toxicity in experimental rats. The extract was found to be active and on fractionation into butanol soluble and chloroform soluble fractions, the activity was traced and found more profound in the chloroform soluble fraction. The butanol soluble bitter rich fraction showed marginal activity. The results based on biochemical estimations have been expressed statistically and are additionally supported by histopathological examination of the liver of experimental rats and pentobarbitone induced sleep time studies in mice.
Karan
M
M
University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
Vasisht
K
K
Handa
S S
SS
D000818:Animals; D000440:Butanols; D002252:Carbon Tetrachloride Poisoning / Q000473:pathology / Q000517:prevention & control*; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology / Q000517:prevention & control*; D002725:Chloroform; D005260:Female; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007194:India; D008099:Liver / Q000473:pathology / Q000503:physiopathology; D008111:Liver Function Tests; D008297:Male; D000432:Methanol; D051379:Mice; D008815:Mice, Inbred Strains; D010424:Pentobarbital / Q000494:pharmacology; D010936:Plant Extracts / Q000627:therapeutic use*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D012890:Sleep / Q000187:drug effects; D012997:Solvents
D000440:Butanols; D006993:Hypnotics and Sedatives; D010936:Plant Extracts; D012997:Solvents; D002725:Chloroform; D010424:Pentobarbital; D000432:Methanol