Phenolic aporphine-benzylisoquinoline alkaloids from Thalictrum faberi.
From the roots of Thalictrum faberi, six new phenolic aporphine-benzylisoquinoline alkaloids, 3-hydroxy-6'-desmethyl-9-O-methylthalifaboramine (1), 3-hydroxythalifaboramine (2), 6'-desmethylthalifaboramine (3); 3,5'-dihydroxythalifaboramine (4), 5'-hydroxythalifaboramine (5) and 3-hydroxy-6'-desmethylthalifaboramine (6) were isolated. Their structures were established through the use of one- and two-dimensional NMR techniques. All of the tested alkaloids showed potent cytotoxic and antimalarial activities.
Lin
L Z
LZ
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago 60612-7231, USA.
Hu
S F
SF
Chu
M
M
Chan
T M
TM
Chai
H
H
Angerhofer
C K
CK
Pezzuto
J M
JM
Cordell
G A
GA
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D000818:Animals; D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D000962:Antimalarials / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D001060:Aporphines / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D002681:China; D006801:Humans; D007546:Isoquinolines / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D007624:KB Cells; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D010946:Plants, Medicinal; D010963:Plasmodium falciparum / Q000187:drug effects; D018894:Reverse Transcriptase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D014407:Tumor Cells, Cultured
D000470:Alkaloids; D019380:Anti-HIV Agents; D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D001060:Aporphines; D007546:Isoquinolines; D010636:Phenols; D018894:Reverse Transcriptase Inhibitors; C081279:aporphine