[Antitumor activity of cold-adapted strains of influenza virus in a model transformed murine tumor cells].
Influenza virus suppressed tumor growth after injection to tumor zone in a dose of 7-8 lg EID50, as was shown for two continuous mouse tumor cell strains, Ehrlich's carcinoma and L-1210 lymphoma. Influenza virus strains differed by their antitumor activity which correlated with their interferonogenic activity. Antitumor activity of influenza virus depended on the site of application, dose of the virus, and interferonogenic activity. Virus therapy of tumors stimulated specific cytotoxic activity towards tumor antigens.
Kiseleva
I V
IV
Egorov
A Iu
AIu
Aleksandrova
G I
GI
Aksenov
O A
OA
Osipova
Z A
ZA
Maĭorova
L P
LP
Klimov
A I
AI
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D002455:Cell Division; D003080:Cold Temperature; D003602:Cytotoxicity, Immunologic; D009980:Influenza A virus / Q000502:physiology*; D007369:Interferon Inducers; D007372:Interferons / Q000096:biosynthesis; D008223:Lymphoma / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D009368:Neoplasm Transplantation
D007369:Interferon Inducers; D007372:Interferons