Trihexyphenidyl in posthemorrhagic dystonia: motor and language effects.
Trihexyphenidyl has been found to be an effective treatment for dystonic movement disorders, improving gross motor function in patients with axial and torsional dystonia, tremors, and myoclonus. In this report, improvements in fine motor control, language, and oral motor skills are described with trihexyphenidyl in an 8-year-old female who developed dystonia after spontaneous bilateral putamenal hemorrhages. No adverse side effects occurred. The mechanism of action of trihexyphenidyl is believed to be in the basal ganglia where it inhibits muscarinic cholinergic receptors and increases the turnover of dopamine.
Pidcock
F S
FS
Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Hoon
A H
AH
Johnston
M V
MV
D018726:Anti-Dyskinesia Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002543:Cerebral Hemorrhage / Q000150:complications*; D002648:Child; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004421:Dystonia / Q000175:diagnosis* / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D007802:Language; D008279:Magnetic Resonance Imaging; D009048:Motor Skills; D011699:Putamen / Q000473:pathology; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014282:Trihexyphenidyl / Q000008:administration & dosage / Q000627:therapeutic use*
D018726:Anti-Dyskinesia Agents; D014282:Trihexyphenidyl