Calcium-binding proteins and development.
The known roles for calcium-binding proteins in developmental signaling pathways are reviewed. Current information on the calcium-binding characteristics of three classes of cell-surface developmental signaling proteins (EGF-domain proteins, cadherins and integrins) is presented together with an overview of the intracellular pathways downstream of these surface receptors. The developmental roles delineated to date for the universal intracellular calcium sensor, calmodulin, and its targets, and for calcium-binding regulators of the cytoskeleton are also reviewed.
Beckingham
K
K
Dept. Biochemistry and Cell Biology, Rice University, Houston TX 77251-1892, USA.
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Andruss
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D000818:Animals; D015820:Cadherins / Q000737:chemistry / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000737:chemistry* / Q000378:metabolism*; D004330:Drosophila; D004627:Embryonic Induction / Q000502:physiology*; D005314:Embryonic and Fetal Development / Q000502:physiology*; D004815:Epidermal Growth Factor / Q000737:chemistry; D006801:Humans; D016023:Integrins / Q000737:chemistry / Q000502:physiology; D008958:Models, Molecular; D011487:Protein Conformation; D015398:Signal Transduction / Q000502:physiology*
D015820:Cadherins; D002135:Calcium-Binding Proteins; D016023:Integrins; D004815:Epidermal Growth Factor