Translocation (2;3)(p21;q26) as the sole anomaly in a case of primary myelofibrosis.
Translocation t(2p;3q) is a rare but recurrent finding in myeloid disorders. We present the first case of primary myelofibrosis with t(2;3)(p21;q26) as the sole chromosomal anomaly. The comparison with the 11 other previously published myeloid-associated t(2p;3q) cases confirms that this nonrandom translocation involves a pluripotent stem cell and is associated with a poor prognosis.
Herens
C
C
Department of Human Genetics, University of Liège, Belgium.
Hermanne
J P
JP
Tassin
F
F
Fassotte
M F
MF
Thiry
A
A
Jamar
M
M
Schaaf-Lafontaine
N
N
Fillet
G
G
Koulischer
L
L
D000368:Aged; D002889:Chromosomes, Human, Pair 2; D002893:Chromosomes, Human, Pair 3; D006801:Humans; D008297:Male; D055728:Primary Myelofibrosis / Q000235:genetics*; D014178:Translocation, Genetic