Biochemical alterations of uterine leiomyoma extracellular matrix in type IV Ehlers-Danlos syndrome.
Collagens and glycosaminoglycans were assessed in 6 leiomyomas from otherwise healthy ("control") patients and 1 leiomyoma from a patient with type IV Ehlers-Danlos syndrome. The type IV Ehlers-Danlos leiomyoma contained less type III collagen and dermatan sulfate than control leiomyomas. This might contribute to the formation of a defective collagen network in type IV Ehlers-Danlos syndrome.
Wegrowski
Y
Y
Laboratory of Biochemistry, UPRESA CNRS (Unite Propre de Recherche de l'Enseignement Supérieur Associée au Centre National de la Recherche Scientifique) 6021, IFR (Institut Federatif de Recherche) 53-Biomolécules, Faculté de Médecine, Reims, France.
Bellon
G
G
Quéreux
C
C
Maquart
F X
FX
D000328:Adult; D003094:Collagen / Q000378:metabolism; D004535:Ehlers-Danlos Syndrome / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism*; D005260:Female; D006025:Glycosaminoglycans / Q000378:metabolism; D006801:Humans; D007889:Leiomyoma / Q000378:metabolism*; D014594:Uterine Neoplasms / Q000378:metabolism*
D006025:Glycosaminoglycans; D003094:Collagen