title: Angiotropic large cell lymphoma presenting as fever of unknown origin.
abstract: BACKGROUND
  Fever has never before been described as the chief complaint and major finding in angiotropic large cell lymphoma (ALCL). ALCL is a rare and usually fatal intravascular tumor characterized by a widespread proliferation of malignant mononuclear cells within vessels of small caliber, causing their blockage. The majority present as high-grade, B-cell lymphomas with a predilection for the central nervous system and the skin.
  
  
  METHODS
  We report a 61-year-old woman who presented with a fever of unknown origin (FUO) that lasted 9 weeks from onset to death. To our knowledge, this is the first case of ALCL to present solely as a FUO, and the second case of ALCL to be diagnosed by muscle biopsy.
  
  
  CONCLUSIONS
  We suggest that this rare malignancy (ALCL) be considered in the differential diagnosis of FUO.
authors: Department of Medicine, Meridia Huron Hospital, East Cleveland, Ohio 44112, USA.
authors: E
authors: E
authors: Kuvliev
authors: T
authors: T
authors: Glamour
authors: R
authors: R
authors: Shekar
authors: B C
authors: BC
authors: West
mesh_terms: D003937:Diagnosis, Differential; D005260:Female; D005335:Fever of Unknown Origin / Q000209:etiology*; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D008875:Middle Aged; D009131:Muscle, Smooth, Vascular / Q000473:pathology*; D009383:Neoplasms, Vascular Tissue / Q000473:pathology*