The time and ease of placement of the chlorhexidine chip local delivery system.
The first local delivery system for an antimicrobial agent was a nondegradable tetracycline-impregnated fiber introduced by Goodson et al in 1979. PerioChip, a biodegradable chip containing chlorhexidine, was recently approved by the Food and Drug Administration for the treatment of adult periodontitis. During several multicenter randomized clinical trials, this product, when used as an adjunct to scaling and root planing, was found to reduce probing depth and improve attachment level significantly more than scaling and root planing alone.
MacNeill
S R
SR
Department of Periodontics, School of Dentistry, University of Missouri-Kansas City, USA.
Johnson
V B
VB
Killoy
W J
WJ
Yonke
M
M
Ridenhour
L
L
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D001673:Biodegradation, Environmental; D002710:Chlorhexidine / Q000008:administration & dosage*; D002983:Clinical Competence; D016001:Confidence Intervals; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010514:Periodontal Pocket / Q000188:drug therapy*; D013997:Time Factors
D000891:Anti-Infective Agents, Local; D003692:Delayed-Action Preparations; D002710:Chlorhexidine