Transcriptional regulation: SWItching circuitry.
Proteins of the SWI/SNF family disrupt chromatin, hydrolysing ATP in the process. How they do so is still mysterious, but recent studies indicate that they can be targeted to the nuclear infrastructure and to particular genes, where they cooperate with other enzymes to activate or repress transcription.
Wade
P A
PA
Laboratory of Molecular Embryology, National Institute of Child Heath and Human Development, NIH, Building 18T, Room 106, Bethesda, Maryland 20892-5431, USA.
Wolffe
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AP
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism / Q000648:ultrastructure; D002843:Chromatin / Q000378:metabolism / Q000648:ultrastructure*; D002868:Chromosomal Proteins, Non-Histone; D004265:DNA Helicases; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000166:cytology / Q000235:genetics; D005656:Fungal Proteins / Q000502:physiology; D005786:Gene Expression Regulation / Q000502:physiology*; D019476:Insect Proteins / Q000235:genetics / Q000502:physiology; D008322:Mammals / Q000235:genetics; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics; D008957:Models, Genetic; D005810:Multigene Family; D009687:Nuclear Proteins / Q000235:genetics / Q000502:physiology*; D011401:Promoter Regions, Genetic; D016601:RNA-Binding Proteins; D011965:Receptors, Glucocorticoid / Q000502:physiology; D017412:Ribonucleoprotein, U1 Small Nuclear / Q000235:genetics / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*; D014158:Transcription, Genetic / Q000502:physiology*
D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D029721:Drosophila Proteins; D005656:Fungal Proteins; D019476:Insect Proteins; D009687:Nuclear Proteins; D016601:RNA-Binding Proteins; D011965:Receptors, Glucocorticoid; D017412:Ribonucleoprotein, U1 Small Nuclear; C078562:SWI1 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; C089969:snf protein, Drosophila; D000255:Adenosine Triphosphate; C513194:Smarca4 protein, mouse; D004265:DNA Helicases