Nackt (nkt), a new hair loss mutation of the mouse with associated CD4 deficiency.
A spontaneous recessive mutation named nackt (symbol: nkt) affecting hair growth and T-cell development was discovered in a moderately inbred stock of mice. Skin lesions were characterized by sparse rough coat, bare patches around the eyes and neck, and a scratching behavior throughout life. Fluorescence-activated cell sorter analysis indicated a deficiency in the CD4(+) 8(-) T-cell subset in the thymus and a marked decrease in CD4(+) T cells in peripheral lymphoid organs. Linkage analysis using a set of molecular markers and an F2 intersubspecific cross indicated that the mutation maps to the central region of mouse chromosome 13, in a region homologous to human chromosome 5q22-q35.
Benavides
F
F
Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina, Pacheco de Melo 3081, 1425 Buenos Aires, Argentina.
Giordano
M
M
Fiette
L
L
Bueno Brunialti
A L
AL
Martin Palenzuela
N
N
Vanzulli
S
S
Baldi
P
P
Schmidt
R
R
Dosne Pasqualini
C
C
Guénet
J
J
D000505:Alopecia / Q000235:genetics*; D000818:Animals; D001522:Behavior, Animal; D015704:CD4 Antigens / Q000235:genetics*; D002874:Chromosome Mapping; D003872:Dermatitis / Q000235:genetics*; D005808:Genes, Recessive; D008040:Genetic Linkage; D006239:Haplotypes; D051379:Mice; D008817:Mice, Mutant Strains; D009154:Mutation; D016176:T-Lymphocyte Subsets; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology
D015704:CD4 Antigens