Rapid eye movement sleep changes during the adaptation night in combat veterans with posttraumatic stress disorder.
BACKGROUND
Hyperarousal in posttraumatic stress disorder (PTSD) is manifested during sleep as well as waking. Elevated rapid eye movement sleep (REMS) phasic activity, likely signifying central nervous system alerting, has been identified in PTSD. The authors reasoned that PTSD compared to control subjects would show particularly increased REMS phasic activity on the first night of polysomnography, with adaptation to a novel environment.


METHODS
First-night polysomnograms of 17 veterans with PTSD were compared with those of 11 control subjects. Sleep was also studied in subsets of both groups over two nights.


RESULTS
On the first night, the PTSD subjects had a higher density of rapid eye movements in the first REMS period. This measure was increased on the first compared to the second night, but there was no interaction effect between night and group.


CONCLUSIONS
REMS changes are again demonstrated in veterans with PTSD. Introduction to a novel environment activated a REMS phasic process, but not differentially in PTSD compared to control subjects.
Ross
R J
RJ
Psychiatry Service, Philadelphia Veterans Affairs Medical Center, Pennsylvania 19104, USA.
Ball
W A
WA
Sanford
L D
LD
Morrison
A R
AR
Dinges
D F
DF
Silver
S M
SM
Kribbs
N B
NB
Mulvaney
F D
FD
Gehrman
P R
PR
McGinnis
D E
DE
D000222:Adaptation, Physiological; D000223:Adaptation, Psychological; D000704:Analysis of Variance; D001143:Arousal / Q000502:physiology*; D016022:Case-Control Studies; D003130:Combat Disorders / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D012895:Sleep, REM / Q000502:physiology*; D017741:Survivors / Q000523:psychology; D014481:United States; D014728:Veterans / Q000523:psychology; D014744:Vietnam