Ramipril reduces QT dispersion in patients with acute myocardial infarction and heart failure.
In a cohort of 67 patients from the Acute Infarction Ramipril Efficacy study, we showed that ramipril therapy was associated with a significant reduction in QT dispersion over a 2-month period after acute myocardial infarction. This reduction of ventricular repolarization inhomogeneity indicates an antiarrhythmic effect and may be an important additional mechanism for the reduced all-cause mortality and sudden death incidence achieved with angiotensin-converting enzyme inhibition after acute myocardial infarction.
Spargias
K S
KS
Institute for Cardiovascular Research, University of Leeds, United Kingdom.
Lindsay
S J
SJ
Hall
A S
AS
Cowan
J C
JC
Ball
S G
SG
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D004562:Electrocardiography / Q000187:drug effects*; D005260:Female; D006333:Heart Failure / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D017257:Ramipril / Q000627:therapeutic use*; D016037:Single-Blind Method
D000806:Angiotensin-Converting Enzyme Inhibitors; D017257:Ramipril