Cell-dependent function of HIV-1 Vif for virus replication (Review).
It has been well established that the Vif protein of human immunodeficiency virus type 1 (HIV-1) acts late in the viral life cycle and increases the infectivity of the progeny virions in a producer cell-dependent manner. The virions produced in the absence of Vif in non-permissive cells (Delta Vif) are defective for a step(s) before and/or during reverse transcription. In this review, the functional and structural analyses of these virions including our new data are summarized.
Inubushi
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Department of Virology, The University of Tokushima School of Medicine, Tokushima 770-8503, Japan.
Adachi
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A
D016346:Gene Products, vif / Q000235:genetics / Q000502:physiology*; D016341:Genes, vif; D015497:HIV-1 / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D009154:Mutation; D014779:Virus Replication / Q000235:genetics / Q000502:physiology*; D054320:vif Gene Products, Human Immunodeficiency Virus
D016346:Gene Products, vif; D054320:vif Gene Products, Human Immunodeficiency Virus