What do we do about Helicobacter pylori?
Heliobacter pylori and nonsteroidal anti-inflammatory drugs (NSAIDs) cause ulcers by different mechanisms. Under some circumstances, patients infected with H pylori may be less prone to NSAID-associated ulcers than those who are H pylori-negative. Eradication trials have yielded differing results. However, those who have studied patients who have a past history of ulcer disease and are already established on NSAIDs have shown no benefit from H pylori eradication.
Hawkey
C J
CJ
University Hospital, Nottingham, Canada. cj.hawkey@nottingham.ac.uk
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D005750:Gastric Juice / Q000187:drug effects / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000382:microbiology*; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D010437:Peptic Ulcer / Q000382:microbiology* / Q000517:prevention & control
D000894:Anti-Inflammatory Agents, Non-Steroidal