title: Long-term fate of heterotopic liver transplants in rats with portal vein inflow only.
abstract: Previous studies have suggested that hepatic arterial flow in heterotopic partial liver transplants is necessary to ensure graft survival and regenerative capacity. This report presents findings in a syngeneic rat strain (Lewis) that partial liver transplants can be successfully heterotopically transplanted in the long term with the only inflow coming from the portal vein. When the host liver undergoes a nearly complete resection at 3-4 weeks, the transplanted liver regenerates to maintain the health of the host. Moderate to massive hepatocellular necrosis occurs in the first 3 months postoperatively, with recovery by 4-5 months. Liver transplants 8-10 months postoperatively appear architecturally normal. No host liver tissues were found to be regenerating after subtotal host liver resection. We conclude that portal vein reconstruction without hepatic arterial inflow can sustain a partial liver transplant in the long term, replacing the function of the host liver.
authors: The San Diego Microsurgical Institute, California 92103, USA.
authors: C H
authors: CH
authors: Yoo
authors: Y
authors: Y
authors: Wang
authors: J
authors: J
authors: Ha
authors: L
authors: L
authors: Mao
authors: S
authors: S
authors: Kim
authors: T
authors: T
authors: Tarin
authors: P
authors: P
authors: Wolf
authors: T P
authors: TP
authors: Youngkin
authors: J J
authors: JJ
authors: Brems
authors: R F
authors: RF
authors: Gittes
authors: M
authors: M
authors: D'Silva
authors: S
authors: S
authors: Lee
mesh_terms: D000714:Anastomosis, Surgical / Q000379:methods; D000818:Animals; D006498:Hepatectomy; D008099:Liver / Q000098:blood supply* / Q000473:pathology; D008115:Liver Regeneration; D016031:Liver Transplantation / Q000379:methods* / Q000473:pathology; D008297:Male; D008866:Microsurgery / Q000379:methods; D011169:Portal Vein / Q000502:physiology* / Q000601:surgery; D011184:Postoperative Period; D051381:Rats; D011917:Rats, Inbred Lew; D013536:Suture Techniques; D013997:Time Factors; D016042:Transplantation, Heterotopic / Q000379:methods* / Q000473:pathology; D016896:Treatment Outcome