Dose-response relationship between sleep duration and human psychomotor vigilance and subjective alertness.
Although it has been well documented that sleep is required for human performance and alertness to recover from low levels after prolonged periods of wakefulness, it remains unclear whether they increase in a linear or asymptotic manner during sleep. It has been postulated that there is a relation between the rate of improvement in neurobehavioral functioning and rate of decline of slow-wave sleep and/or slow-wave activity (SWS/SWA) during sleep, but this has not been verified. Thus, a cross-study comparison was conducted in which dose-response curves (DRCs) were constructed for Stanford Sleepiness Scale (SSS) and Psychomotor Vigilance Task (PVT) tests taken at 1000 hours by subjects who had been allowed to sleep 0 hours, 2 hours, 5 hours or 8 hours the previous night. We found that the DRCs to each PVT metric improved in a saturating exponential manner, with recovery rates that were similar [time constant (T) approximately 2.14 hours] for all the metrics. This recovery rate was slightly faster than, though not statistically significantly different from, the reported rate of SWS/SWA decline (T approximately 2.7 hours). The DRC to the SSS improved much more slowly than psychomotor vigilance, so that it could be fit equally well by a linear function (slope = -0.26) or a saturating exponential function (T = 9.09 hours). We conclude that although SWS/SWA, subjective alertness, and a wide variety of psychomotor vigilance metrics may all change asymptotically during sleep, it remains to be determined whether the underlying physiologic processes governing their expression are different.
Jewett
M E
ME
Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, Mass., USA. mjewett@gcrc.bwh.harvard.edu
Dijk
D J
DJ
Kronauer
R E
RE
Dinges
D F
DF
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001143:Arousal / Q000502:physiology*; D003071:Cognition / Q000502:physiology; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D008297:Male; D011597:Psychomotor Performance / Q000502:physiology*; D012895:Sleep, REM / Q000502:physiology*; D013997:Time Factors