[Creutzfeldt-Jakob disease and transfusional risk: the point in 1998].
As both iatrogenic and experimental transmission of Creutzfeldt-Jakob disease (CJD) have been demonstrated, potential blood transfusion-related CJD through blood component contamination is not unlikely. Recent studies also suggest that B lymphocytes would play a crucial role in the disease pathogenesis. However, to date, there is no epidemiological evidence suggesting that classical transmission of CJD would involve B lymphocytes. To reduce the theoretical risk of such transmission and as no biological marker of the disease is currently available, at-risk blood donors are excluded and leukocyte depletion has been introduced. Furthermore, the recent discovery of a new variant of the disease (nwCJD) which is caused by the bovine agent and has typical tropism for lymphoreticular tissues should lead to close surveillance.
Laperche
S
S
Laboratoire de virologie transfusionnelle, Institut national de la transfusion sanguine, Paris.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D002417:Cattle; D007562:Creutzfeldt-Jakob Syndrome / Q000453:epidemiology / Q000635:transmission*; D005602:France / Q000453:epidemiology; D006801:Humans; D012307:Risk Factors; D065227:Transfusion Reaction