Importance of CD23 for collagen-induced arthritis: delayed onset and reduced severity in CD23-deficient mice.
Increased expression of the low affinity receptor for IgE, FcepsilonRII/CD23 has been observed in rheumatoid arthritis. In view of this, we have investigated the expression and influence of CD23 in collagen-induced arthritis (CIA), an animal model for rheumatoid arthritis. CD23+ cells were analyzed in lymph nodes of DBA/1 mice immunized with bovine collagen type II (BCII) in CFA or with CFA only. The percentage of CD23+ lymph node cells was increased in both BCII/CFA- and CFA-immunized mice at 1, 3, and 7 wk after immunization compared with unimmunized mice, indicating a role for the adjuvant to trigger general inflammation and CD23 expression. To investigate the functional role of CD23 in CIA, CD23-deficient mice on the DBA/1 genetic background were studied. After immunization with BCII/CFA, these mice developed CIA with delayed onset and reduced severity compared with wild-type mice. These findings suggest that an increased number of CD23+ cells is part of an inflammatory response and that CD23 expression is of pathogenic importance in the arthritic process.
Kleinau
S
S
Department of Genetics and Pathology, Uppsala University, Sweden. Sandra.Kleinau@patologi.uu.se
Martinsson
P
P
Gustavsson
S
S
Heyman
B
B
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000209:etiology* / Q000235:genetics* / Q000276:immunology; D003094:Collagen / Q000276:immunology*; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008817:Mice, Mutant Strains; D017455:Receptors, IgE / Q000096:biosynthesis / Q000172:deficiency / Q000235:genetics* / Q000502:physiology*; D013045:Species Specificity; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D017455:Receptors, IgE; D014409:Tumor Necrosis Factor-alpha; D003094:Collagen