title: Imaging of the thorax in the management of germ cell testicular tumours.
abstract: OBJECTIVE
  To evaluate role of chest computed tomography (CTC) and chest radiography (CXR) in management of patients with testicular germ cell tumours (GCT).
  
  
  METHODS
  An analysis was undertaken of staging and re-assessment CTC and CXR examinations performed on patients with GCT over a 4.5-year period. Data were obtained on clinical presentation, tumour histology, tumour marker levels and clinical course. Consensus review interpretation was combined with these data to obtain a 'standard of reference'. Sensitivity, specificity and predictive values were derived by comparison of original imaging reports to 'standard of reference'.
  
  
  RESULTS
  Six hundred and twenty-three CTC examinations on 207 patients with GCT were included. Intrathoracic metastases were identified in 1% of seminoma patients compared with 20% of non-seminoma (NSGCT) patients. CTC was more accurate than CXR in the detection of intrathoracic metastases at 0.97, 0.96-0.98 (95% CI) compared with 0.91, 0.89-0.93. The agreement between imaging techniques and the standard of reference (determined by Kappa statistic) was respectively 0.96 for CTC and 0.65 for CXR. In GCT patients undergoing re-assessment with both CXR and CTC, CXR never detected unknown intrathoracic metastatic disease. Abdominopelvic lymphadenopathy was associated with intrathoracic metastases (P < 0.001), however re-assessment CTC did identify intrathoracic metastases in 27 cases without concurrent abdominopelvic disease. CXR was negative in 19 of these.
  
  
  CONCLUSIONS
  Routine interval CXRs are unnecessary in NSGCT patients undergoing regular re-assessment CTC due to the low additional yield and limited effect on management. Re-assessment should still include CTC. In low risk, pure seminoma patients (abdominal CT and marker negative) re-assessment CTC can be safely avoided. Baseline CTC is advocated with CXR alone for re-assessment.
authors: Department of Radiology, Western General Hospital, Edinburgh, UK.
authors: P M
authors: PM
authors: White
authors: D J
authors: DJ
authors: Adamson
authors: G C
authors: GC
authors: Howard
authors: A R
authors: AR
authors: Wright
mesh_terms: D005188:False Negative Reactions; D005189:False Positive Reactions; D005500:Follow-Up Studies; D018237:Germinoma / Q000000981:diagnostic imaging* / Q000556:secondary*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D009367:Neoplasm Staging; D012189:Retrospective Studies; D018239:Seminoma / Q000000981:diagnostic imaging / Q000556:secondary; D013736:Testicular Neoplasms / Q000473:pathology*; D013899:Thoracic Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary*; D014057:Tomography, X-Ray Computed