Bacterial solutions to the iron-supply problem.
The insolubility of Fe3+ necessitates special mechanisms for iron acquisition in most organisms. Bacteria use siderophores to chelate Fe3+ and iron in heme, hemoglobin, transferrin and lactoferrin, and employ novel mechanisms for receptor-dependent iron transport and iron-regulated gene expression. These mechanisms involve transfer of energy from the cytoplasmic membrane to the outer membrane to drive active transport and might induce transcription of transport genes by transmitting a signal from the cell surface.
Braun
V
V
Lehrstuhl Mikrobiologie/Membranphysiologie, Universität Tübingen, Auf der Morgenstelle 28, D-72076 Tübingen, Germany. volkmar.braun@mikrobio.uni-tuebingen.de
Killmann
H
H
D001419:Bacteria / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D004734:Energy Metabolism; D017136:Ion Transport; D007501:Iron / Q000378:metabolism*; D008954:Models, Biological; D017262:Siderophores / Q000378:metabolism
D017262:Siderophores; D007501:Iron