Estimation of oncostatin M (OSM) secretion by peritoneal macrophages with regard to the progression of transplantable melanomas.
The authors have studied the influence of two kinds of transplantable melanomas on the secretion of oncostatin M (OSM) and total proteins by peritoneal macrophages. Culture supernatant samples were tested by ELISA. The macrophages of melanoma-bearing animals released a lower amount of OSM than those of the controls. At the same time the results showed statistically significant increase of protein content in the supernatants of cultured macrophages from melanoma-bearing hamsters in comparison with the controls. However, it has not been possible to demonstrate any relationship between melanoma progression and changes in the secretion of OSM by peritoneal macrophages.
Kozłowska
K
K
Department of Embryology, Medical University, Gdańsk, Poland.
Cichorek
M
M
Zarzeczna
M
M
D000818:Animals; D006224:Cricetinae; D006801:Humans; D017737:Macrophages, Peritoneal / Q000378:metabolism*; D008297:Male; D008546:Melanoma, Experimental / Q000378:metabolism*; D008647:Mesocricetus; D009368:Neoplasm Transplantation; D053683:Oncostatin M; D010455:Peptides / Q000378:metabolism*
C508351:OSM protein, human; D010455:Peptides; D053683:Oncostatin M