[The role of endothelial mechanosensitivity in vessel bed responses to changes in blood pressure in cats].
In 19 anaesthetised cats, the response of vascular bed to increasing perfusion pressure at a constant blood flow perfusion consisted of two phases: a myogenic constriction and a subsequent arterial dilatation. The latter depended on ability of the endothelium to relax the smooth muscle under stress. The findings suggest that the control of the smooth muscle tone by a stress has to fight against the myogenic constriction and thus determines the changes in vascular resistance induced by an increased arterial pressure.
Mel'kumiants
A M
AM
Institute of Experimental Cardiology, Moscow, Russia.
Balashov
S A
SA
Kartamyshev
S P
SP
Naumov
A Iu
AIu
Sheptutsolov
K V
KV
D000818:Animals; D001158:Arteries / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D002415:Cats; D004730:Endothelium, Vascular / Q000502:physiology; D006614:Hindlimb / Q000098:blood supply; D006706:Homeostasis / Q000502:physiology; D010477:Perfusion; D013314:Stress, Mechanical; D014655:Vascular Resistance / Q000502:physiology; D014664:Vasodilation / Q000502:physiology