[Nerve growth factor auto-antibodies in the sera of mothers of schizophrenic children and children from high risk group].
A level of autoantibodies (aAB) to nerve growth factor (NGF) was measured in blood serum of children from 4 groups: 1) schizophrenic patients; 2) children from the families, in which one of the parents suffered with schizophrenia (high risk groups of schizophrenia); 3) children with residual-organic damages of CNS; 4) control group. This index was also determined in their mothers. Significant elevation of a titer of aAB to NGF was observed in blood of children from groups 1 and 2 as well as in their mothers, as compared with 3 and 4 groups. Among the mothers of the children from 1 and 2 groups there were met women with different endogenous mental disorders, with the disorders of personality as well as mentally healthy women. An increase of a level of aAB to NGF was found in all the women from groups 1 and 2, independently of their mental status including mentally healthy women. Such results allow to consider elevated level of aAB to NGF as a risk factor of mental pathology.
Zakharenko
O M
OM
Kliushnik
T P
TP
Kozlova
I A
IA
Kozlovskaia
G V
GV
Danilovskaia
E V
EV
Bashina
V M
VM
Simashkova
V M
VM
Goriunova
A V
AV
Kalinina
M A
MA
D000293:Adolescent; D001323:Autoantibodies / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008429:Maternal Welfare; D009414:Nerve Growth Factors / Q000097:blood* / Q000276:immunology*; D010554:Personality Disorders / Q000175:diagnosis; D011247:Pregnancy; D012307:Risk Factors; D012559:Schizophrenia / Q000276:immunology*; D012565:Schizophrenic Psychology
D001323:Autoantibodies; D009414:Nerve Growth Factors