title: Sequential irrigation with common detergents: a promising new method for decontaminating orthopedic wounds.
abstract: This investigation sought to determine the capacity of irrigation solutions in decontaminating orthopedic wounds challenged with a polymicrobial inoculum. Rats were divided into two groups, a control group and a treatment group. After creation of a dorsolumbar incision and placement of a wire through the spinous process, rats were inoculated with Staphylococcus aureus and Pseudomonas aeruginosa. Wounds were irrigated with control or treated solutions. At 2 weeks, cultures were obtained. There were statistically significant differences between groups regarding total number of culture positive sites (P < 0.001), culture-positive animals (P = 0.02), and quantitative cultures (P < 0.02). Sequential irrigation with surfactants lowers bacteria counts recovered from polymicrobial wounds.
authors: University of Missouri-Columbia Hospital and Clinics, USA.
authors: T
authors: T
authors: Burd
authors: G D
authors: GD
authors: Christensen
authors: J O
authors: JO
authors: Anglen
authors: B J
authors: BJ
authors: Gainor
authors: B P
authors: BP
authors: Conroy
authors: W A
authors: WA
authors: Simpson
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D016009:Chi-Square Distribution; D015169:Colony Count, Microbial; D003902:Detergents / Q000008:administration & dosage*; D004195:Disease Models, Animal; D019637:Orthopedic Procedures / Q000009:adverse effects; D011552:Pseudomonas Infections / Q000628:therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D012965:Sodium Chloride / Q000008:administration & dosage; D012996:Solutions; D013203:Staphylococcal Infections / Q000628:therapy*; D013530:Surgical Wound Infection / Q000209:etiology / Q000628:therapy*; D007507:Therapeutic Irrigation / Q000379:methods*; D016896:Treatment Outcome; D014945:Wound Healing
chemical_list: D003902:Detergents; D012996:Solutions; D012965:Sodium Chloride