title: DNA pooling and dense marker maps: a systematic search for genes for cognitive ability.
abstract: Pooling DNA from subjects within a group and comparing the pooled DNA across groups for a dense map of DNA markers offers a solution to the conundrum that linkage is systematic but not powerful whereas allelic association is powerful but not systematic. We used DNA pooling to screen 66 markers on chromosome 22 in original and replication samples of children of high general cognitive ability (g) and controls of average g. Although none of these markers survived our three-stage screening design (original pooling, replication pooling, individual genotyping), the results of DNA pooling were largely confirmed by individual genotyping. We can therefore exclude associations of major effect size on chromosome 22 for g, a key variable for cognitive neuroscience research on learning and memory.
authors: Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, UK.
authors: L
authors: L
authors: Hill
authors: I W
authors: IW
authors: Craig
authors: P
authors: P
authors: Asherson
authors: D
authors: D
authors: Ball
authors: T
authors: T
authors: Eley
authors: T
authors: T
authors: Ninomiya
authors: P J
authors: PJ
authors: Fisher
authors: D
authors: D
authors: Turic
authors: P
authors: P
authors: McGuffin
authors: M J
authors: MJ
authors: Owen
authors: K
authors: K
authors: Chorney
authors: M J
authors: MJ
authors: Chorney
authors: C P
authors: CP
authors: Benbow
authors: D
authors: D
authors: Lubinski
authors: L A
authors: LA
authors: Thompson
authors: R
authors: R
authors: Plomin
mesh_terms: D000483:Alleles; D002648:Child; D002874:Chromosome Mapping; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics; D003071:Cognition / Q000502:physiology*; D004247:DNA / Q000032:analysis* / Q000235:genetics; D004591:Electrophoresis, Polyacrylamide Gel; D005819:Genetic Markers / Q000502:physiology*; D005838:Genotype; D006801:Humans; D007361:Intelligence Tests; D019655:Quantitative Trait, Heritable; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D005819:Genetic Markers; D004247:DNA