Relationship of portal-drained viscera and liver net flux of glucose, lactate, volatile fatty acids, and nitrogen metabolites to milk production in the ewe.
The objectives of this study were, first, to determine the relationship between hepatic glucose release and milk production and, second, to determine the relationship between net hepatic uptake of gluconeogenic precursors and milk production. Nine multiparous ewes were individually penned and fed an alfalfa hay-based diet for ad libitum intake. Catheters were surgically placed in the portal vein, a branch of the hepatic vein, a mesenteric vein, and the abdominal aorta. Metabolite fluxes across the portal-drained viscera and liver were subsequently measured at 1, 3, 6, and 10 wk after parturition. Net hepatic glucose release, net hepatic lactate uptake, and net hepatic propionate uptake increased with increased milk production. Hepatic oxygen consumption increased with increased net hepatic glucose release. Net hepatic glucose release increased with increased hepatic propionate uptake and tended to increase with increases in metabolized amino acid and lactate uptakes. The observed increases in oxygen consumption by the portal-drained viscera with increased milk production were probably the result of increased nutrient flux. Increased hepatic oxygen consumption with increased milk production was probably due to increased glucose and urea synthesis.
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USDA, ARS, Roman L. Hruska US Meat Animal Research Center, Clay Center, NE 68933, USA.
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D000641:Ammonia / Q000097:blood; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D005232:Fatty Acids, Volatile / Q000097:blood; D005260:Female; D005943:Gluconeogenesis; D007774:Lactation / Q000502:physiology*; D019344:Lactic Acid / Q000097:blood; D008099:Liver / Q000098:blood supply / Q000378:metabolism*; D009584:Nitrogen / Q000097:blood; D010101:Oxygen Consumption; D011168:Portal System / Q000502:physiology; D012756:Sheep / Q000502:physiology*; D014781:Viscera / Q000098:blood supply / Q000378:metabolism*
D001786:Blood Glucose; D005232:Fatty Acids, Volatile; D019344:Lactic Acid; D000641:Ammonia; D009584:Nitrogen