The comparison of gonadotropin-releasing hormone agonist therapy and intraperitoneal Ringer's lactate solution in prevention of postoperative adhesion formation in rat models.
OBJECTIVE
To evaluate gonadotropin-releasing hormone agonists (GnRH-a) therapy and intraperitoneal Ringer's lactate solution (RL) for the prevention of postsurgical adhesion formation in rat models.


METHODS
Forty rats were randomized into four groups: Group I was the control; in group II, RL was applied at the surgery; group III and IV received preoperative subcutaneous injections of the GNRH-a leuprolide acetate and only the diluent of the GNRH-a respectively. A standard lesion was created over the uterus of each rat. Adhesions were scored at relaparotomy 3 weeks later. Analysis of variance (Kruskal-Wallis) and Mann-Whitney U-tests were used for the statistical evaluation.


RESULTS
The average adhesion scores were 2.7+/-0.26, 1.4+/-0.27, 0.9+/-0.18, and 2.5+/-0.34 in groups I, II, III, and IV respectively. There were significant differences between the scores of groups I and II (P<0.01), groups I and III (P<0.001), groups II and IV (P<0.05), and groups III and IV (P<0.01); but not between the scores of groups II and III, and groups I and IV (P>0.05).


CONCLUSIONS
GNRH-a was successful in reducing postoperative adhesion formation but was not superior to intraperitoneal RL.
Canbaz
M A
MA
Department of Obstetrics and Gynecology, Ondokuz Mayis University, Samsun, Turkey.
Ustün
C
C
Koçak
I
I
Yanik
F F
FF
D000818:Animals; D005260:Female; D007552:Isotonic Solutions / Q000008:administration & dosage / Q000627:therapeutic use*; D016729:Leuprolide / Q000008:administration & dosage / Q000627:therapeutic use*; D010532:Peritoneal Diseases / Q000517:prevention & control; D011183:Postoperative Complications / Q000517:prevention & control*; D051381:Rats; D000077325:Ringer's Lactate; D000267:Tissue Adhesions / Q000517:prevention & control*
D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D016729:Leuprolide