Recurrent clear cell carcinoma of the ovary changing into producing parathyroid hormone-related protein (PTH-rP) with hypercalcemia.
We experienced the case of a clear cell carcinoma of the ovary arising from an endometrial cyst, which started to produce parathyroid hormone-related protein (PTH-rP) in a recurrent tumor, thus inducing hypercalcemia. Using immunohistochemical analysis, we demonstrated that the primary carcinoma was immunonegative for PTH-rP, but that the recurrent carcinoma was strongly immunopositive for PTH-rP.
Koshiyama
M
M
Department of Obstetrics and Gynecology, Tenri Hospital, Nara, Japan.
Fujii
H
H
Konishi
M
M
Nanno
H
H
Hayashi
M
M
Tauchi
K
K
Yoshida
M
M
D018262:Adenocarcinoma, Clear Cell / Q000737:chemistry / Q000150:complications / Q000378:metabolism*; D004715:Endometriosis / Q000150:complications; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D007150:Immunohistochemistry; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010051:Ovarian Neoplasms / Q000737:chemistry / Q000150:complications / Q000378:metabolism*; D044162:Parathyroid Hormone-Related Protein; D014176:Protein Biosynthesis; D011506:Proteins / Q000032:analysis
C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins