Expression of somatostatin receptors in oncocytic (Hürthle cell) neoplasia of the thyroid.
Ten consecutive patients with Hürthle cell lesions of the thyroid (nodule/adenoma/carcinoma) were studied by (111)In-DTPA-D-Phe1-octreotide scintigraphy. Octreotide scintigraphy localized the primary Hürthle cell tumour in eight patients as distinct areas of increased uptake of radionuclide. Two patients with Hürthle cell carcinoma, previously thyroidectomized, had their metastases visualized by octreotide scintigraphy. Northern analyses showed expression of multiple somatostain receptor subtypes. Visualization of the Hürthle cell tumour may be due to a higher expression of somatostatin receptors in the lesions than in surrounding normal thyroid tissue. The tissue/blood (111)In concentration ratios for tumour samples from five patients showed clearly higher values than observed for normal connective tissue, muscle or lymph nodes. A relatively high uptake of (111)In was also observed in goiter tissue, which may lead to misinterpretations. The main indication for octreotide scintigraphy in patients with Hürthle cell carcinoma is suspicion of metastatic disease.
Tisell
L E
LE
Department of Surgery, Sahlgrenska University Hospital, Göteborg, Sweden.
Ahlman
H
H
Wängberg
B
B
Kölby
L
L
Fjälling
M
M
Forssell-Aronsson
E
E
Mölne
J
J
Nilsson
O
O
D018249:Adenoma, Oxyphilic / Q000000981:diagnostic imaging / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015152:Blotting, Northern; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood / Q000378:metabolism*; D015282:Octreotide / Q000031:analogs & derivatives; D004369:Pentetic Acid / Q000031:analogs & derivatives*; D012333:RNA, Messenger / Q000378:metabolism; D011877:Radionuclide Imaging; D017481:Receptors, Somatostatin / Q000097:blood / Q000378:metabolism*; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism*
D007205:Indium Radioisotopes; D009363:Neoplasm Proteins; D012333:RNA, Messenger; D017481:Receptors, Somatostatin; C101130:somatostatin receptor type 1; C071632:SDZ 215-811; D004369:Pentetic Acid; C093733:somatostatin receptor 2; D015282:Octreotide