Pain-free intralesional injection of triamcinolone for the treatment of keloid.
Intralesional injection of triamcinolone acetonide (TA) for the treatment of keloid is painful, and lidocaine-mixed preparations are much the same. I have injected TA (10 mg/ml) at the speed of 3-6 ml/hour using an electric syringe pump 40 times for the treatment of 10 keloids, 18 times without lidocaine and 22 times with lidocaine. The 95% confidence intervals (CI) of the 100 mm visual analogue pain scale of the TA alone group and the lidocaine-mixed group were 2.0 to 9.5 mm and 1.0 to 6.7 mm respectively, suggesting that both are practically pain-free. The speed of injection is an important determinant of pain in intralesional chemotherapy. The injection should be extremely slow and lidocaine should be added for sensitive patients.
Ono
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Department of Plastic and Reconstructive Surgery, Toyokawa City Hospital, Japan.
D005938:Glucocorticoids / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D015552:Injections, Intralesional / Q000379:methods; D007627:Keloid / Q000188:drug therapy*; D008875:Middle Aged; D009339:Needles; D010146:Pain / Q000517:prevention & control; D010147:Pain Measurement; D013594:Syringes; D014222:Triamcinolone Acetonide / Q000008:administration & dosage* / Q000627:therapeutic use
D005938:Glucocorticoids; D014222:Triamcinolone Acetonide