Genetic and physical mapping of the CLN6 gene on chromosome 15q21-23.
CLN6, the gene for a variant late infantile neuronal ceroid lipofuscinosis, has been mapped to chromosome 15q21-23 by homozygosity mapping. At present the family resource consists of 31 families. By the analysis of additional polymorphic markers in this resource the critical region has been narrowed down from 12 cM to less than 4 cM. A physical map is being constructed using YAC and PAC clones as a prerequisite to transcript mapping.
Sharp
J D
JD
Department of Paediatrics, University College London Medical School, The Rayne Institute, University Street, London, WC1E 6JJ, United Kingdom.
Wheeler
R B
RB
Lake
B D
BD
Fox
M
M
Gardiner
R M
RM
Williams
R E
RE
D000483:Alleles; D002874:Chromosome Mapping; D002884:Chromosomes, Human, Pair 15; D005260:Female; D015723:Gene Library; D006239:Haplotypes; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D009472:Neuronal Ceroid-Lipofuscinoses / Q000235:genetics*; D010375:Pedigree; D010641:Phenotype; D020161:Physical Chromosome Mapping; D016324:Sequence Tagged Sites