title: Primary melanocytoma arising from the thoracic leptomeninges case.
abstract: Primary melanocytoma arising from the leptomeninges of the spinal cord is very rare. A surgical specimen of a thoracic meningeal tumor was resected from a 75-year-old woman complaining of gait disturbance was investigated. Magnetic resonance imaging and myelography showed a dumb-bell-type tumor in the subdural space at the 1st to 2nd thoracic vertebrae. The tumor was subtotally resected because of adhesion to the lamina and thoracic medulla. The localized, gelatinous black tumor showed a well-defined margin without dissemination or infiltration. The tumor had a thin capsule and was composed of solid proliferation of neoplastic melanocytes. Neither whorl formation nor foci of palisaded nuclei were observed. The neoplastic cells were of two major types: an epithelioid- or polygonal-shaped type and a spindle-shaped type, and had a large nucleus, a prominent nucleolus, coarse chromatin, and melanin-pigments in their cytoplasm. Only a few mitotic figures were observed. They were positive for HMB-45 and S-100 protein. This case was considered to be primary melanocytoma arising from the thoracic leptomeninges.
authors: Department of Orthopedics, Mito Saiseikai General Hospital, Ibaraki, Japan.
authors: H
authors: H
authors: Shimoda
authors: K
authors: K
authors: Oka
authors: Y
authors: Y
authors: Naoi
authors: S
authors: S
authors: Nishida
authors: T
authors: T
authors: Oka
authors: Y
authors: Y
authors: Nakazato
authors: N
authors: N
authors: Mori
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008545:Melanoma / Q000473:pathology*; D008577:Meningeal Neoplasms / Q000473:pathology*; D013120:Spinal Cord Neoplasms / Q000473:pathology