Powerful tools for genetic analysis come of age.
Microscopic arrays of oligonucleotides or cDNA containing up to several hundred thousand different sequences are starting to influence methodologies and paths to discovery in genomics. Gene polymorphisms and mutations can be found and gene expression measured with unprecedented speed and parallelism. The principles of this modern technology and some of the problems awaiting further study are discussed.
Graves
D J
DJ
Department of Chemical Engineering, University of Pennsylvania, Philadelphia 19104-6393, USA.
D001709:Biotechnology / Q000639:trends*; D002874:Chromosome Mapping / Q000639:trends*; D004252:DNA Mutational Analysis / Q000639:trends*; D018076:DNA, Complementary; D015345:Oligonucleotide Probes
D018076:DNA, Complementary; D015345:Oligonucleotide Probes