title: A pilot study of the disposition of pilocarpine in plasma, saliva and urine after a single oral dose.
abstract: Concentrations of pilocarpine in plasma, saliva and urine from three healthy male volunteers were measured using a fluorescence derivatisation method, following administration of a single 10 mg oral dose. Pharmacokinetic parameter values were estimated from concentration-time profiles. Linear correlations between plasma and saliva pilocarpine concentrations (r2=0.945, n=10, p<0.001; r2=0.954, n=12, p<0.001) and plasma concentrations and salivation rate (r2=0. 863, n=12, p<0.001; r2=0.862, n=15, p<0.001) were established. Pilocarpine and an unidentified metabolite, respectively 20.3% and 34.7% of the oral dose, were excreted into urine.
authors: School of Pharmacy, University of Otago, PO Box 913, Dunedin, New Zealand.
authors: C
authors: C
authors: Aromdee
authors: M M
authors: MM
authors: Ferguson
authors: R
authors: R
authors: Ledger
authors: J
authors: J
authors: Wall
mesh_terms: D000328:Adult; D019540:Area Under Curve; D001711:Biotransformation; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged; D018721:Muscarinic Agonists / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D010862:Pilocarpine / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D010865:Pilot Projects; D012463:Saliva / Q000378:metabolism*; D012472:Salivation / Q000187:drug effects
chemical_list: D018721:Muscarinic Agonists; D010862:Pilocarpine