title: [Pharmacokinetic data for different 5-aminosalicylic acid and budesonide preparations].
abstract: Different orally and rectally applicable forms of 5-ASA and budesonide have been developed to achieve sufficient high concentrations of the active moieties at the site of inflammation (small and/or large bowel) and to limit the systemic action of the drugs. This concept of drug targeting could be accomplished by both special galenic formulations and by utilizing the pharmacokinetic properties of the agents especially their high intestinal and hepatic presystemic elimination. Thus, 5-ASA and budesonide represent drugs of first choice in the treatment of Crohn's disease and ulcerative colitis. This review describes the various pharmacokinetic and (patho)physiologic factors and their impact on drug delivery and biological availability of the different 5-ASA and budesonide preparations.
authors: Dr. Margarete Fischer-Bosch-Institut für Klinische Pharmakologie, Stuttgart. ulrich.klotz@ikp-stuttgart.de
authors: U
authors: U
authors: Klotz
mesh_terms: D019819:Budesonide / Q000008:administration & dosage / Q000493:pharmacokinetics*; D016503:Drug Delivery Systems; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000097:blood* / Q000188:drug therapy; D019804:Mesalamine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013329:Structure-Activity Relationship
chemical_list: D019804:Mesalamine; D019819:Budesonide