Fine-needle aspiration cytology of a mediastinal seminoma associated with multilocular thymic cyst.
Multiloculated thymic cysts are uncommon lesions that can be either acquired or associated with malignancies. This report describes the fine-needle aspiration (FNA) cytology of a mediastinal seminoma with prominent cystic change, confirmed by surgical pathology examination and ancillary studies performed on both the cytology and tissue specimens. The FNA cytology revealed clusters of malignant oval-to-polygonal-shaped cells with large oval nuclei possessing prominent nucleoli set in a pale-to-eosinophilic cytoplasm. These cells were surrounded by a dense lymphoid infiltrate along with a few noncaseating granulomas. The large malignant seminoma cells stained positive for placental alkaline phosphatase (PLAP) and negative for both low molecular and broad-spectrum cytokeratin. The differential diagnosis of malignancies associated with thymic cysts is presented. To the best of our knowledge, this is the first report of aspiration cytology of a mediastinal seminoma associated with a multilocular cyst.
Silverman
J F
JF
Department of Pathology, Allegheny University of the Health Sciences, Allegheny University Hospital, Pittsburgh, PA 15212-4772, USA. JSilverm@aherf.edu
Olson
P R
PR
Dabbs
D J
DJ
Landreneau
R
R
D001707:Biopsy, Needle; D006801:Humans; D008476:Mediastinal Cyst / Q000150:complications* / Q000473:pathology*; D008479:Mediastinal Neoplasms / Q000150:complications* / Q000473:pathology*; D018239:Seminoma / Q000150:complications* / Q000473:pathology*