title: Pneumococcal vaccine: a second look. Solution for SC or IM injection: pneumococcal vaccine.
abstract: Pneumo 23 degrees , like the pneumococcal vaccines tested in randomised comparative trials, may slightly reduce the incidence of pneumococcal pneumonia in subjects with no particular risk factors, but fails to alter the overall incidence of pneumonia or its related mortality. In subjects at high risk of infection, pneumococcal vaccines have not been proven clinically effective in well-conducted trials.  According to available retrospective studies Pneumo 23 degrees  may, at best, slightly reduce the risk of severe pneumococcal infection.  It has, however, no demonstrated effect on mortality and does not protect against pneumococci with diminished sensitivity to penicillin.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001428:Bacterial Vaccines / Q000008:administration & dosage* / Q000009:adverse effects; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D005334:Fever / Q000139:chemically induced; D005387:Finland; D006801:Humans; D007723:Korea; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D010146:Pain; D011008:Pneumococcal Infections / Q000517:prevention & control*; D012307:Risk Factors; D012871:Skin Diseases; D013296:Streptococcus pneumoniae / Q000276:immunology*; D016896:Treatment Outcome; D014481:United States
chemical_list: D001428:Bacterial Vaccines