T-box genes: what they do and how they do it.
Brachyury is the founder member of the T-box family of transcription factors, which is characterized by a DNA-binding domain of approximately 200 amino acids. Members of the T-box gene family play important roles in the development of both vertebrate and invertebrate embryos, including the control of gastrulation, development of the heart, and perhaps even the decision as to whether to form arm or leg. An understanding of how the T-box genes act requires analysis of how their expression is controlled, identification of their target genes, and an insight into how different family members exert different effects.
Smith
J
J
Division of Developmental Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK NW7 1AA. jim@nimr.mrc.ac.uk
D000818:Animals; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics*; D005326:Fetal Proteins; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D008958:Models, Molecular; D011487:Protein Conformation; D020825:T-Box Domain Proteins; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics*; D000098908:Brachyury Protein
D004268:DNA-Binding Proteins; D005326:Fetal Proteins; D020825:T-Box Domain Proteins; D014157:Transcription Factors; D000098908:Brachyury Protein