[Circannual rhythm of the risk of IgE-dependent sensitization to acari depending on the birth date. Interpretation and practical consequences in prevention].
The role of allergenic environment during the first weeks of life for the future development of IgE-dependent allergy is well documented for cyclic allergens. That is less evident for permanent antigens as house dust mites. The aim of this work was to find a possible relation between the birth date and house dust mite hypersensitivity to have a better prevention. The result of Rast d1 which show an IgE-dependent allergy to Dermatophagoides pteronyssinus was correlated to the month of birth of 5, 747 children and adolescents with a suspected allergic respiratory disease. Possible bias induced by sex and personal/family history were mathematically corrected. A correlation curve between the month of birth and the frequency of positive Rast d1 was deduced. There is a circannual rhythm risk for house dust mite allergy according to the month of birth. It draw a sinusoid curve with a peak at 104 percent in october and a minimum at 96 percent in april. These data were discussed. The minimum of risk was possibly due to better early ecologic way of life for infants born during the spring. Preventive methods were available against house dust mites. They could be organized for infants. We hope that more pediatricians were concerned by primary prevention of house dust mite allergy.
de Montis
G
G
Hôpital Saint-Vincent de Paul, Faculté Cochin-Port-Royal, Université Paris.
D000053:Acari / Q000276:immunology*; D000293:Adolescent; D000485:Allergens / Q000276:immunology; D000818:Animals; D002648:Child; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D007231:Infant, Newborn; D008297:Male; D010507:Periodicity; D011852:Radioallergosorbent Test; D012130:Respiratory Hypersensitivity / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control; D012307:Risk Factors; D012621:Seasons; D012737:Sex Factors
D000485:Allergens; D007073:Immunoglobulin E