Standard serum concentrations and normal fluctuations of CEA, CA 50 and CA 242 during twelve months in men and women aged 60-64 years without malignant disease.
OBJECTIVE
To establish standard serum concentrations of carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 50 and CA 242 in cancer-free subjects in the age group during which cancers are likely to develop.


METHODS
Prospective study.


METHODS
University hospital, Sweden.


METHODS
Blood samples obtained by venepuncture on four occasions during one year.


METHODS
Consultation with the Regional Cancer Registry to exclude those who had previously had malignant disease diagnosed or developed cancer during and up to two years after the end of the clinical part of the study. Serum concentrations of CEA, CA 50, and CA 242.


RESULTS
The 90th centile was 5.6 ng/ml for CEA, 30.1 U/ml for CA 50, and 24.5 U/ml for CA 242. The mean (SD) serum concentrations were 2.6 ng/ml (2.2) for CEA, 13.2 U/ml (11.4) for CA 50, and 10.6 U/ml (9.6) for CA 242. Serum concentrations of CEA were significantly higher (p < 0.001) among smokers. The intraindividual fluctuations were 16%, 16%, and 14%, respectively.


CONCLUSIONS
Serum concentrations of CEA, CA 50, and CA 242 were higher in this study than previously reported, probably because the subjects were older than in other reports. The fluctuations were small. Serum concentrations of CEA were higher in smokers than in non-smokers.
Engarås
B
B
Department of Surgery, Sahlgrenska University Hospital, Göteborg, Sweden.
Hafström
L
L
Kewenter
J
J
Nilsson
O
O
Wedel
H
H
D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood*; D002272:Carcinoembryonic Antigen / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012016:Reference Values
D015295:Antigens, Tumor-Associated, Carbohydrate; C074601:CA 242 antigen; C082699:CA-50 antigen; D002272:Carcinoembryonic Antigen