Elevated day 3 serum follicle stimulating hormone and/or estradiol may predict fetal aneuploidy.
OBJECTIVE
To determine whether baseline serum FSH and/or E2 concentrations can predict the risk for fetal chromosomal abnormalities.


METHODS
Case control study.


METHODS
Reproductive technology program at a university hospital.


METHODS
Patients who underwent dilation and curettage (D + C), and whose products of conception were karyotyped.


METHODS
Patients underwent natural conception or controlled ovarian hyperstimulation followed by intrauterine insemination, in vitro fertilization and embryo transfer, gamete intrafallopian transfer, or zygote intrafallopian transfer.


METHODS
Baseline serum FSH and E2 concentrations and fetal karyotype.


RESULTS
Genetic evaluation of 78 D + C specimens revealed 34 normal and 44 abnormal fetal karyotypes. A significantly greater proportion of women with abnormal fetal karyotype had elevated baseline serum FSH (> or =15 mIU/mL [RIA] or 10 mIU/mL [Immulite]) and/or E2 > or = 50 pg/mL [Immulite]) compared with women of normal fetal karyotype. Among karyotypically abnormal abortuses, autosomal trisomy was the most common abnormality noted (79.5%), followed by mosaicism (6.8%), triploidy (6.8%), monosomy XO (4.5%), and balanced translocation (2.3%).


CONCLUSIONS
Baseline serum FSH and/or E2 concentrations may be valuable as predictors of fetal aneuploidy.
Nasseri
A
A
Department of Obstetrics and Gynecology, Mount Sinai Medical Center, New York, New York 10029, USA.
Mukherjee
T
T
Grifo
J A
JA
Noyes
N
N
Krey
L
L
Copperman
A B
AB
D000030:Abortion, Missed / Q000097:blood; D000022:Abortion, Spontaneous / Q000097:blood; D000328:Adult; D000782:Aneuploidy; D016022:Case-Control Studies; D002869:Chromosome Aberrations; D004107:Dilatation and Curettage; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D005865:Gestational Age; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009006:Monosomy; D009030:Mosaicism; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012099:Reproductive Techniques; D014314:Trisomy
D004958:Estradiol; D005640:Follicle Stimulating Hormone