Synthesis of novel chelating agents and their effect on cadmium decorporation.
A series of novel dithiocarbamates, disodium salts of N-glucamyl-N-dithiocarboxyl-amino acids, were synthesized, and their usefullness as an antagonist of cadmium intoxication was investigated. These chelating agents were found to be effective in both acute and repeated exposure cadmium poisoning. The results showed that the cadmium mobilizing properties of disodium N-(2,3,4,5, 6-pentahydroxylhexyl)-N-dithiocarbamate-L-threoninate and disodium N-(2,3,4,5,6-pentahydroxylhexyl)-N-dithiocarbamate-L-cysteinate are clearly superior to those of sodium N-(4-methoxybenzyl)-D-glucamine-N-carbodithioate (MeOBGDTC) revealed in the experiments described here. The toxicity of these novel compounds is modest, and their effect on the concentrations of essential metal ions in the renal cortex is quite small in comparison with that of a group treated with cadmium only. The new dithiocarbomates were identified by MS, rather than by elemental analysis, as they were extremely hygroscopic.
Wang
C
C
School of Pharmaceutical Sciences, Beijing Medical University, Beijing 100083, PRC.
Fang
Y
Y
Peng
S
S
Ma
D
D
Zhao
J
J
D000818:Animals; D002104:Cadmium / Q000378:metabolism*; D002105:Cadmium Poisoning / Q000188:drug therapy; D002614:Chelating Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D051381:Rats; D017208:Rats, Wistar; D013859:Thiocarbamates / Q000138:chemical synthesis* / Q000494:pharmacology
D002614:Chelating Agents; D013859:Thiocarbamates; D002104:Cadmium