Stressor-induced alterations in serotonergic activity in an animal model of depression.
The present study examined the effect of two neurogenic stressors (air puff and restraint) and a metabolic stressor (lipopolysaccharide; LPS 100 microg/kg, i.p.) on accumbal serotonergic neurotransmission in the olfactory bulbectomized (OB) rat model of depression. Both air puff and restraint stress caused greater increases in accumbal 5-HIAA in OB than in sham-operated rats. In contrast, bulbectomy resulted in a blunted serotonergic response to a challenge with LPS (a metabolic stressor). In addition, OB rats displayed significantly lower basal levels of 5-HIAA than sham-operated counterparts, a finding consistent with previous reports of the OB rat being a model of hyposerotonergic depression. The relevance of these findings to stressor-provoked depressive-like behaviors in the OB rat are discussed.
Connor
T J
TJ
Department of Pharmacology, National University of Ireland, Galway.
Song
C
C
Leonard
B E
BE
Anisman
H
H
Merali
Z
Z
D000388:Air; D000818:Animals; D003863:Depression / Q000209:etiology / Q000503:physiopathology*; D005110:Extracellular Space / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008070:Lipopolysaccharides; D008297:Male; D009714:Nucleus Accumbens / Q000378:metabolism; D009830:Olfactory Bulb / Q000601:surgery; D009994:Osmolar Concentration; D010812:Physical Stimulation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012149:Restraint, Physical; D012701:Serotonin / Q000502:physiology*; D013312:Stress, Physiological / Q000139:chemically induced / Q000209:etiology / Q000503:physiopathology*; D009435:Synaptic Transmission / Q000502:physiology*
D008070:Lipopolysaccharides; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid