title: Specific attentional dysfunction in adults following early start of cannabis use.
abstract: OBJECTIVE
  The present study tested the hypothesis that chronic interference by cannabis with endogenous cannabinoid systems during peripubertal development causes specific and persistent brain alterations in humans. As an index of cannabinoid action, visual scanning, along with other attentional functions, was chosen. Visual scanning undergoes a major maturation process around age 12-15 years and, in addition, the visual system is known to react specifically and sensitively to cannabinoids.
  
  
  METHODS
  From 250 individuals consuming cannabis regularly, 99 healthy pure cannabis users were selected. They were free of any other past or present drug abuse, or history of neuropsychiatric disease. After an interview, physical examination, analysis of routine laboratory parameters, plasma/urine analyses for drugs, and MMPI testing, users and respective controls were subjected to a computer-assisted attention test battery comprising visual scanning, alertness, divided attention, flexibility, and working memory.
  
  
  RESULTS
  Of the potential predictors of test performance within the user group, including present age, age of onset of cannabis use, degree of acute intoxication (THC+THCOH plasma levels), and cumulative toxicity (estimated total life dose), an early age of onset turned out to be the only predictor, predicting impaired reaction times exclusively in visual scanning. Early-onset users (onset before age 16; n = 48) showed a significant impairment in reaction times in this function, whereas late-onset users (onset after age 16; n = 51) did not differ from controls (n = 49).
  
  
  CONCLUSIONS
  These data suggest that beginning cannabis use during early adolescence may lead to enduring effects on specific attentional functions in adulthood. Apparently, vulnerable periods during brain development exist that are subject to persistent alterations by interfering exogenous cannabinoids.
authors: Department of Psychiatry, Georg August University, Göttingen, Germany.
authors: H
authors: H
authors: Ehrenreich
authors: T
authors: T
authors: Rinn
authors: H J
authors: HJ
authors: Kunert
authors: M R
authors: MR
authors: Moeller
authors: W
authors: W
authors: Poser
authors: L
authors: L
authors: Schilling
authors: G
authors: G
authors: Gigerenzer
authors: M R
authors: MR
authors: Hoehe
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D001288:Attention / Q000187:drug effects; D001289:Attention Deficit Disorder with Hyperactivity / Q000139:chemically induced* / Q000453:epidemiology; D002186:Cannabinoids / Q000378:metabolism; D002188:Cannabis / Q000009:adverse effects*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D011930:Reaction Time / Q000187:drug effects
chemical_list: D002186:Cannabinoids