title: Absence of Peyer's patches and abnormal lymphoid architecture in chronic proliferative dermatitis (cpdm/cpdm) mice.
abstract: The chronic proliferative dermatitis (cpdm) mutation causes inflammation in multiple organs, most prominently in the skin. Examination of the immune system revealed severe abnormalities in the architecture of lymphoid tissues. Peyer's patches were absent. In contrast, the spleen, lymph nodes, and nasal-associated lymphoid tissues were present. The spleen had normal numbers of T and B cells, but the spleen, lymph nodes, and nasal-associated lymphoid tissues had poorly defined follicles and lacked germinal centers and follicular dendritic cells. The marginal zone in the spleen was absent. The total concentration of serum IgG, IgA, and IgE in cpdm/cpdm mice was significantly decreased, whereas serum IgM was normal. Fecal IgA was low to undetectable in mutant mice, and the concentration of fecal IgM was increased. The titer of DNP-specific Abs following immunization with DNP-keyhole limpet hemocyanin was significantly decreased for all IgG subclasses. In contrast, T cell function appeared normal as assessed by evaluation of the contact hypersensitivity response in cpdm/cpdm mice. The cpdm mutation causes a complex phenotype that is characterized by multiorgan inflammation and the defective development of lymphoid tissues. The cpdm/cpdm mouse may be a useful model to study the factors that control the development of lymphoid tissues, in particular the Peyer's patches, and the mechanisms that control the humoral immune response.
authors: Department of Veterinary Pathobiology, Purdue University, West Lafayette, IN 47907, USA. harm@vet.purdue.edu
authors: H
authors: H
authors: HogenEsch
authors: S
authors: S
authors: Janke
authors: D
authors: D
authors: Boggess
authors: J P
authors: JP
authors: Sundberg
mesh_terms: D000818:Animals; D002908:Chronic Disease; D003872:Dermatitis / Q000097:blood / Q000235:genetics / Q000276:immunology* / Q000473:pathology*; D003877:Dermatitis, Contact / Q000276:immunology; D005243:Feces / Q000737:chemistry; D005260:Female; D005434:Flow Cytometry; D006241:Haptens / Q000276:immunology; D006433:Hemocyanins / Q000276:immunology; D007136:Immunoglobulins / Q000096:biosynthesis / Q000097:blood; D007150:Immunohistochemistry; D007271:Injections, Intradermal; D008221:Lymphoid Tissue / Q000276:immunology / Q000473:pathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D010581:Peyer's Patches / Q000276:immunology / Q000473:pathology*; D013154:Spleen / Q000166:cytology; D014409:Tumor Necrosis Factor-alpha / Q000008:administration & dosage
chemical_list: C042158:2,4-dinitrophenyl keyhole limpet hemocyanin; D006241:Haptens; D007136:Immunoglobulins; D014409:Tumor Necrosis Factor-alpha; D006433:Hemocyanins