Attenuation of anti-ischemic efficacy during chronic therapy with nicorandil in patients with stable angina pectoris.
After 2 weeks of nicorandil therapy, time to ischemia on stress testing was significantly less than on day 1 and not different from placebo. These data are consistent with attenuation of the anti-ischemic effects of this drug and suggest that the potassium channel-opening properties do not compensate for development of attenuation to the nitrate component of nicorandil.
Rajaratnam
R
R
Department of Cardiology, Concord Repatriation General Hospital, University of Sydney, Australia.
Brieger
D B
DB
Hawkins
R
R
Freedman
S B
SB
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy* / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D018592:Cross-Over Studies; D004110:Diltiazem / Q000627:therapeutic use; D004311:Double-Blind Method; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000517:prevention & control; D020108:Nicorandil / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors; D014700:Verapamil / Q000627:therapeutic use
D000319:Adrenergic beta-Antagonists; D002121:Calcium Channel Blockers; D020108:Nicorandil; D014700:Verapamil; D004110:Diltiazem