title: Association of high-dose intravenous methylprednisolone with reversal of blindness from lightning in two patients.
abstract: OBJECTIVE
  To report possibly beneficial effects of treatment with high-dose corticosteroids given intravenously to two patients with loss of vision after lightning strikes.
  
  
  METHODS
  Case reports.
  
  
  METHODS
  Two patients who suffered the effects of a lightning strike.
  
  
  METHODS
  High-dose intravenous methylprednisolone (NASCIS-2 Protocol).
  
  
  METHODS
  Vision recovery, pupil responses, and optic nerve appearance.
  
  
  RESULTS
  One patient had unilateral ophthalmoscopically visible abnormality with light perception vision and a relative afferent defect in that eye; vision recovered to 20/25. The other patient had no light perception, nonreactive pupils, and normal fundus examinations in both eyes; vision recovered bilaterally to normal (20/20).
  
  
  CONCLUSIONS
  High-dose intravenous corticosteroid treatment in these patients may have had a role in their visual recovery.
authors: Seacoast Ophthalmology, Portsmouth, New Hampshire 03801, USA.
authors: M E
authors: ME
authors: Norman
authors: B R
authors: BR
authors: Younge
mesh_terms: D000328:Adult; D001766:Blindness / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D015168:Lightning Injuries / Q000150:complications*; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000627:therapeutic use; D009883:Ophthalmic Solutions / Q000008:administration & dosage / Q000627:therapeutic use; D009900:Optic Nerve / Q000502:physiology; D011680:Pupil / Q000502:physiology; D011681:Pupil Disorders / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D014792:Visual Acuity / Q000502:physiology
chemical_list: D009883:Ophthalmic Solutions; D008775:Methylprednisolone