Death related to midazolam overdose during endoscopic retrograde cholangiopancreatography.
We report a midazolam-related death that occurred during endoscopic retrograde cholangiopancreatography (ERCP). The acute intoxication due to midazolam overdose was confirmed by high-pressure liquid chromatography (HPLC) analysis of the blood samples taken from the patient in the intensive care unit (2.8 microg/ml) and postmortem (2.4 microg/ml). The case strongly emphasizes the necessity of the precautions that should be taken when midazolam is intravenously administered.
Michalodimitrakis
M
M
Department of Forensic Pathology, University of Crete, Iraklion, Greece.
Christodoulou
P
P
Tsatsakis
A M
AM
Askoxilakis
I
I
Stiakakis
I
I
Mouzas
I
I
D014151:Anti-Anxiety Agents / Q000506:poisoning*; D002760:Cholangiopancreatography, Endoscopic Retrograde; D002851:Chromatography, High Pressure Liquid; D016292:Procedural Sedation; D000075202:Contraindications; D062787:Drug Overdose / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D007275:Injections, Intravenous; D007431:Intraoperative Complications; D008297:Male; D008874:Midazolam / Q000506:poisoning*; D008875:Middle Aged
D014151:Anti-Anxiety Agents; D008874:Midazolam