title: Diverticulitis versus colon cancer: differentiation with helical CT findings.
abstract: OBJECTIVE
  To retrospectively determine the computed tomographic (CT) signs associated with diverticulitis or colon cancer, and to prospectively apply these signs in the differentiation of these diseases.
  
  
  METHODS
  Fifty-eight CT scans in cases of proved diverticulitis (n = 27) or colon cancer (n = 31) were evaluated retrospectively by radiologists (blinded to the proved diagnosis) for the presence or absence of previously reported CT findings. These findings were correlated with the pathologic or final clinical diagnosis. The retrospective findings were applied in a prospective evaluation with a new set of 72 CT scans. The same five radiologists rendered a diagnosis according to a five-point confidence scale from definitely benign to definitely malignant. Individual and consensus readings were correlated with the final diagnosis.
  
  
  RESULTS
  Retrospectively, pericolonic inflammation (P < .01) and segment involvement greater than 10 cm (P < .012) were the most significant findings for diverticulitis; pericolonic lymph nodes (P < .0001) and luminal mass (P < .003) were the most significant findings for colon cancer. Prospectively, an unequivocal diagnosis was made correctly in 16 (40%) of 40 cases of diverticulitis and 21 (66%) of 32 cases of colon cancer.
  
  
  CONCLUSIONS
  When there are no pericolonic lymph nodes adjacent to a segment of colonic wall thickening, with pericolonic inflammatory changes, the most likely diagnosis is diverticulitis. When pericolonic lymph nodes are present, with or without pericolonic edema, the most likely diagnosis is colon cancer.
authors: Department of Radiology, University of Texas Health Science Center at San Antonio 78284-7800, USA.
authors: K N
authors: KN
authors: Chintapalli
authors: S
authors: S
authors: Chopra
authors: A A
authors: AA
authors: Ghiatas
authors: C C
authors: CC
authors: Esola
authors: S F
authors: SF
authors: Fields
authors: G D
authors: GD
authors: Dodd
mesh_terms: D003110:Colonic Neoplasms / Q000000981:diagnostic imaging*; D003287:Contrast Media; D003937:Diagnosis, Differential; D004239:Diverticulitis, Colonic / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011446:Prospective Studies; D012189:Retrospective Studies; D012810:Sigmoid Diseases / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media