title: Occult carcinoma discovered after simple hysterectomy treated with postoperative radiotherapy.
abstract: OBJECTIVE
  Treatment of patients with occult carcinoma of the cervix discovered after simple hysterectomy is controversial. The purpose of this review is to examine our results with postoperative radiotherapy and to compare them to similar reports and to reports of treatment with radical parametrectomy.
  
  
  METHODS
  Between November 1979 and April:, 18 patients were treated with radiotherapy at the University of Virginia for invasive carcinoma of the cervix discovered after simple hysterectomy. Simple hysterectomy was performed in all 18 patients for a variety of indications. After surgery gross residual carcinoma remained in four patients; and microscopic disease was present at the surgical margins in two patients. The remaining patients had no evidence of residual disease. All 18 patients had postoperative radiotherapy with or without brachytherapy. The endpoints for this study were local control, survival, and treatment-related toxicity. Actuarial rates were calculated using the Life Table method.
  
  
  RESULTS
  Median follow-up for all 18 patients was 42 months (range 2-202 months). Both the 5 and the 10-year actuarial local control rates were 88%. Five and 10-year actuarial overall survival rates were both 93%. Two patients had both local and distant cancer recurrences. There were no recurrences among the six patients treated with external beam alone. The remaining patients are all alive without evidence of disease, including two patients who had gross residual disease after surgery, and one patient with both microscopic positive margin and a positive lymph node (the only patient to undergo lymph node sampling). There was no severe acute morbidity and only one patient had severe late morbidity.
  
  
  CONCLUSIONS
  Invasive carcinoma found after simple hysterectomy may be treated safely and effectively with postoperative radiotherapy. Patients with known residual disease following surgery do poorly with either radiotherapy or reoperation, but treatment with radiotherapy alone may be less morbid. Also, for the treatment of minimal disease external beam radiation to the pelvis appears to be as effective and possibly less morbid than radical reoperation.
authors: Department of Therapeutic Radiation and Oncology, The University of Virginia Health Sciences Center, Charlottesville, USA.
authors: C H
authors: CH
authors: Crane
authors: B F
authors: BF
authors: Schneider
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000532:radiotherapy; D000328:Adult; D000368:Aged; D002278:Carcinoma in Situ / Q000601:surgery; D018196:Carcinoma, Adenosquamous / Q000175:diagnosis / Q000532:radiotherapy; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000532:radiotherapy; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D009382:Neoplasms, Unknown Primary / Q000175:diagnosis / Q000532:radiotherapy*; D012189:Retrospective Studies; D002578:Uterine Cervical Dysplasia / Q000601:surgery; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000532:radiotherapy*