On the possible use of a new boron compound, hydroxysalicylhydroxamato boron(III), and ultrasound in the treatment of female mice bearing the Ehrlich ascites carcinoma cells.
The inhibitory effects of a new boron compound, hydroxy salicylhydroxamato boron (III) (SHB) and ultrasound of frequency 25 KHz (US) on the growth of ascites tumor in female Swiss mice were studied by monitoring the survival and the tumor growth in the treated tumor bearing mice and also the transplantability and the DNA synthesis in the treated tumor (Ehrlich ascites carcinoma) cells. While SHB alone produced a highly significant antitumor activity, US alone produced a small but significant effect. The combination of SHB and US produced significantly greater antitumor activity than SHB alone. The mechanisms of SHB and US actionary are discussed.
Ghosh
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P
Department of Chemistry, Jadavpur University, Calcutta, India.
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Bag
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SP
Sur
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Chatterjee
S N
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D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001896:Boron Compounds / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D051379:Mice; D014464:Ultrasonic Therapy
D000970:Antineoplastic Agents; D001896:Boron Compounds; C118570:hydroxysalicylhydroxamato boron(III)