Making sense of the COP9 signalosome. A regulatory protein complex conserved from Arabidopsis to human.
The COP9 signalosome, once defined as a repressor complex of light-activated development in Arabidopsis, has recently been found in humans and is probably present in most multicellular organisms. The COP9 signalosome is closely related to the lid sub-complex of the 26S proteasome in structural composition and probably shares a common evolutionary ancestor. A multifaceted role of the COP9 signalosome in cell-signaling processes is hinted at by its associated novel kinase activity, as well as the involvement of its subunits in regulating multiple cell-signaling pathways and cell-cycle progression. The molecular genetic studies in Arabidopsis suggest that the complex functions as part of a highly conserved regulatory network, whose physiological role in animals remains to be determined.
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Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520-8104, USA. nwei@peaplant.biology.yale.edu
Deng
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D000818:Animals; D017360:Arabidopsis / Q000378:metabolism; D000075686:COP9 Signalosome Complex; D002467:Cell Nucleus / Q000378:metabolism; D006801:Humans; D046912:Multiprotein Complexes; D010447:Peptide Hydrolases; D010940:Plant Proteins / Q000737:chemistry / Q000378:metabolism*; D011506:Proteins; D015398:Signal Transduction
D046912:Multiprotein Complexes; D010940:Plant Proteins; D011506:Proteins; D010447:Peptide Hydrolases; D000075686:COP9 Signalosome Complex