Establishment and characterization of a mouse strain (TLL) that spontaneously develops T-cell lymphomas/leukemia.
In this study, a mouse strain (TLL) that spontaneously develops T-cell lymphomas/leukemia with an early onset and high incidence was established and characterized. All tumors analyzed were found to express the alpha,beta T-cell receptor, and the majority of them had a mature, CD3+CD4+CD8- immunophenotype. In a few cases, tumors with a more immature CD3+CD4+CD8+ phenotype were isolated. Expanded phenotyping using a broad panel of lymphocyte differentiation markers confirmed the mature T-cell phenotype of the tumors. Histologic and cell cycle analysis of the tumors revealed an aggressive lymphoblastic malignancy with a very high proliferation rate and widespread engagement of bone marrow and lymphoid as well as nonlymphoid organs. Thus, the TLL mouse strain represents a unique model for the analysis of the oncogenesis and progression of mature T-cell tumors and for the development of therapeutic measures to combat such tumors.
Eriksson
B
B
Department of Cell and Molecular Biology, Umeå University, Sweden.
Johansson
A S
AS
Roos
G
G
Levan
G
G
Holmberg
D
D
D000818:Animals; D015139:Blotting, Southern; D001853:Bone Marrow / Q000473:pathology; D002478:Cells, Cultured; D002678:Chimera / Q000235:genetics; D004195:Disease Models, Animal; D004622:Embryo, Mammalian; D005260:Female; D018390:Gene Targeting; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007135:Immunoglobulin Variable Region / Q000235:genetics; D016130:Immunophenotyping; D015458:Leukemia, T-Cell / Q000235:genetics* / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000235:genetics* / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains / Q000235:genetics*; D013154:Spleen / Q000473:pathology
D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region