title: Ovarian function after bone marrow transplantation performed before menarche.
abstract: OBJECTIVE
  To examine the long term effect of bone marrow transplantation (BMT) on ovarian function in girls.
  
  
  METHODS
  Eighteen girls who underwent BMT before menarche, had been disease free for more than six years, and were over 14 years of age at the time of study were investigated. The preparative regimen consisted of irradiation and chemotherapy. The occurrence of menarche and changes in basal serum follicle stimulating hormone (FSH) concentrations were studied.
  
  
  RESULTS
  Twelve patients achieved menarche at a median age of 12.8 years. Age at transplant was significantly younger in patients who achieved menarche than in those who did not (mean (SD), 7.2 (0.5) v 11.1 (1.7) years). Basal FSH began to rise to menopausal concentrations after 10 years of age, and the girls who did not experience menarche had a sustained rise in FSH concentrations. Among those with raised FSH concentrations, five girls experienced menarche while serum FSH values were decreasing and four achieved menarche while FSH remained raised.
  
  
  CONCLUSIONS
  The high incidence of menarche suggests a favourable outcome of ovarian function in girls who undergo BMT at a young age.
authors: Department of Pediatrics, Tokai University School of Medicine, Bohseidai, Isehara-shi, Kanagawa-ken 259-1193, Japan.
authors: M
authors: M
authors: Matsumoto
authors: O
authors: O
authors: Shinohara
authors: H
authors: H
authors: Ishiguro
authors: T
authors: T
authors: Shimizu
authors: K
authors: K
authors: Hattori
authors: M
authors: M
authors: Ichikawa
authors: H
authors: H
authors: Yabe
authors: C
authors: C
authors: Kubota
authors: M
authors: M
authors: Yabe
authors: S
authors: S
authors: Kato
mesh_terms: D000293:Adolescent; D000367:Age Factors; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002648:Child; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005500:Follow-Up Studies; D006402:Hematologic Diseases / Q000628:therapy; D006801:Humans; D008572:Menarche; D010053:Ovary / Q000503:physiopathology*; D011379:Prognosis; D017741:Survivors
chemical_list: D005640:Follicle Stimulating Hormone