title: Large juxtamedullary glomeruli and afferent arterioles in healthy primates.
abstract: BACKGROUND
  Differences in the functional demands of superficial and juxtaglomerular nephrons could result in differences in glomerular size between these two types of nephrons. This concept is based on animal models in which the juxtamedullary glomeruli and afferent arteriole diameters are indeed larger than those in the outer cortical zones. However, this difference was not confirmed in human necropsy studies. To obtain further information in living primates, we have made unbiased estimates of glomerular and afferent arteriole dimensions in three cortical zones (superficial, midcortical, and juxtamedullary) in young, adult, normotensive monkeys.
  
  
  METHODS
  In each animal (N = 6), the right kidney was perfusion fixed and prepared for unbiased stereological estimation of glomerular number and size. The left kidney vasculature was fixed while relaxed and at a known intravascular pressure. Thereafter, afferent arteriolar dimensions were estimated using light and confocal microscopy.
  
  
  RESULTS
  The mean glomerular volume was variable between animals (coefficient of variation, 23%) and was largest in the juxtamedullary zone. Afferent arteriolar lumen diameter varied little between animals (coefficient of variation, 3%), but was also the largest in the juxtamedullary zone. No sclerotic glomeruli were found in any of the animals.
  
  
  CONCLUSIONS
  The findings show that in normal primates, as previously shown in other animals, juxtamedullary glomeruli and afferent arteriolar diameters are larger compared with those in the outer cortical zones.
authors: Department of Nephrology, Aarhus University Hospital, Denmark. karin@farm.au.dk
authors: K
authors: K
authors: Skov
authors: J R
authors: JR
authors: Nyengaard
authors: A
authors: A
authors: Patwardan
authors: M J
authors: MJ
authors: Mulvany
mesh_terms: D000818:Animals; D001160:Arterioles / Q000033:anatomy & histology*; D002522:Chlorocebus aethiops / Q000033:anatomy & histology*; D007672:Kidney Cortex / Q000033:anatomy & histology / Q000098:blood supply; D007678:Kidney Glomerulus / Q000033:anatomy & histology* / Q000098:blood supply; D008297:Male; D018613:Microscopy, Confocal