Genetic vaccines.
In a few short years, genetic vaccine technology has moved rapidly from a novel concept to an important strategy for the development of human and veterinary vaccines, for numerous indications. This article discusses current areas in which further refinements in technology will influence a variety of infectious disease treatments, including intramuscular and intradermal inoculation, gene gun inoculation, the mechanism of antigen presentation, and the use of genetic adjuvants.
Haynes
J R
JR
Vaccine Research Department, Heska Corporation, Fort Collins, Colorado, USA. haynesj@heska.com
D000276:Adjuvants, Immunologic; D000818:Animals; D002986:Clinical Trials as Topic; D016207:Cytokines / Q000008:administration & dosage* / Q000235:genetics*; D006801:Humans; D007114:Immunization / Q000379:methods; D019444:Vaccines, DNA / Q000008:administration & dosage* / Q000276:immunology*
D000276:Adjuvants, Immunologic; D016207:Cytokines; D019444:Vaccines, DNA