title: A statistical evaluation of the Youden Matched-Pairs Procedure.
abstract: AOAC INTERNATIONAL currently permits investigators to use the Youden Matched-Pairs Procedure to obtain estimates of the method performance indicators repeatability and reproducibility (S(r) and SR, respectively). This report explains the statistical model assumptions upon which the procedure is based, provides validity tests for several of these assumptions, explains conditions under which Youdens' "precision error" is not consistent with precision estimate S(r) or SR as defined by AOAC INTERNATIONAL, and indicates when precision estimates based on the procedure should be interpreted with caution or should not be used.
authors: U.S. Food and Drug Administration, Department of Health and Human Services, Washington, DC 20204, USA.
authors: F D
authors: FD
authors: McClure
mesh_terms: D007753:Laboratories / Q000592:standards* / Q000706:statistics & numerical data; D008433:Mathematics; D015233:Models, Statistical; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity