[The modulating effect of endothelial relaxing factor on the reactivity of the myocardium and of arterial vascular strips].
Under successive coperfusion of the arterial vascular rings and right atrial trabecula an examination of effects of endothelium-derived NO on reactions of vessel and myocardial trabecula recipient has been done. During arterial rings contraction a relaxing factor was released into solution. By means of chemical de-endothelialization, NO-synthase inhibition and L-arginine the role of endothelium as a source of modulated substances and the role of NO as a main dilated substance for recipient preparations were shown. The direct effect of endothelium-derived NO on a tension and reactivity of myocardial trabecula has been demonstrated.
Zhukova
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AV
A. A. Bogomoletz Institute of Physiology, NAS, Ukraine.
D000818:Animals; D001120:Arginine / Q000494:pharmacology; D016275:Atrial Function; D002339:Carotid Arteries / Q000187:drug effects* / Q000502:physiology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006325:Heart Atria / Q000187:drug effects; D066298:In Vitro Techniques; D009569:Nitric Oxide / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D009599:Nitroprusside / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D010477:Perfusion / Q000379:methods; D011817:Rabbits; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology; D019323:omega-N-Methylarginine / Q000494:pharmacology
D004791:Enzyme Inhibitors; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D009599:Nitroprusside; D019323:omega-N-Methylarginine; D009569:Nitric Oxide; D001120:Arginine; D019001:Nitric Oxide Synthase; D009638:Norepinephrine