title: Smooth pursuit performance in families with multiple occurrence of schizophrenia and nonpsychotic families.
abstract: BACKGROUND
  Eye tracking dysfunction (ETD) has been put forward as a trait marker for biological susceptibility to schizophrenia with the hope of identifying a link to specific cerebral lesions.
  
  
  METHODS
  Eye movements were recorded using infrared oculography in 8 families (67 members) showing multiple occurrence of schizophrenia and in 9 nonpsychotic families (80 members). Triangle wave stimuli at 15 degrees/s and 30 degrees/s were used and gains (eye velocity/target velocity), rates and amplitudes of different saccade categories (catch-up, back-up, anticipatory saccades, and squarewave-jerks) were determined.
  
  
  RESULTS
  In the relatives, the same deficit in maintenance of smooth pursuit performance was found as was seen in the schizophrenic patients. This deficit, which was not observed in the nonpsychotic families, consisted of lower gains for leftward as compared to rightward pursuit. This was emphasized most clearly at 30 degrees/s and was associated with an excess of catch-up saccades in the schizophrenic patients, whereas in the relatives a tendency to exhibit more and larger anticipatory saccades was observed.
  
  
  CONCLUSIONS
  The results confirm the hypothesis that eye-tracking dysfunction is a phenotypic marker for genetic liability to schizophrenia. Neurophysiologically, a cerebral dysfunction which includes one or more of the oculomotor centers can be assumed in subjects who carry a genetic susceptibility to schizophrenia.
authors: Department of Psychiatry, University of Luebeck School of Medicine, Germany.
authors: R
authors: R
authors: Lencer
authors: C P
authors: CP
authors: Malchow
authors: K
authors: K
authors: Krecker
authors: A
authors: A
authors: Nolte
authors: M
authors: M
authors: Pinnow
authors: S Z
authors: SZ
authors: von Siefart
authors: E
authors: E
authors: Schwinger
authors: V
authors: V
authors: Arolt
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001921:Brain / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011698:Pursuit, Smooth / Q000502:physiology*; D012438:Saccades / Q000502:physiology*; D012559:Schizophrenia / Q000235:genetics* / Q000503:physiopathology*