Expression and regulation of collagenase-3 (MMP-13) in human malignant tumors.
Human collagenase-3 (MMP-13) is a matrix metalloproteinase originally identified in breast carcinomas. Recent studies have revealed that this enzyme is also produced by a variety of malignant tumors including head and neck carcinomas, chondrosarcomas and basal cell carcinomas of the skin. In all cases, the expression of collagenase-3 is associated with aggressive tumors. Different cytokines, growth factors and tumor promoters are able to up-regulate collagenase-3 expression in tumor cells or in stromal cells surrounding epithelial tumor cells. Functional analysis of the collagenase-3 gene promoter has allowed the identification of AP-1 and OSE-2 elements mediating, at least in part, its expression in both normal and pathological conditions.
Balbín
M
M
Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Oviedo, Spain.
Pendás
A M
AM
Uría
J A
JA
Jiménez
M G
MG
Freije
J P
JP
López-Otín
C
C
D001943:Breast Neoplasms / Q000201:enzymology; D002357:Cartilage Diseases / Q000201:enzymology; D017364:Collagenases / Q000235:genetics*; D015971:Gene Expression Regulation, Enzymologic; D006258:Head and Neck Neoplasms / Q000201:enzymology; D006801:Humans; D053509:Matrix Metalloproteinase 13; D009369:Neoplasms / Q000201:enzymology*
D017364:Collagenases; C507079:MMP13 protein, human; D053509:Matrix Metalloproteinase 13