[Role of Epstein-Barr virus in the pathogenesis of lymphogranulomatosis. Immunohistochemical and molecular-biological (hybridization in situ) research].
EBV was found in 72.7% of 66 LGM patients aged from 4 to 76 years. EBV occurred in 100% of lymphoid depletion, 81% of mixed-cell variant and in 66.6% of nodular sclerosis. The occurrence of virus-positive cases was significantly higher at the age of under 10 years and over 50 years (100%). In the intermediate group it was 65.4 (p < 0.01). Necrotic changes in the lymph nodes were observed more frequently (p < 0.05) when EBV was present. The virus-positive cases of mixed-cell LGM are characterized by increased number of tumor and plasma cells (p < 0.05). EBV was also in a latent state without signs of lytic replication. The influence of the virus manifested in higher expression of antigens CD30 (p < 0.05) and bcl oncoproteins (p < 0.01) as well as in weak CD79 expression (p < 0.05).
Leenman
E E
EE
N. N. Petrov Research Institute of Oncology, St-Petersburg.
Afanas'ev
B V
BV
Pozharisskiĭ
K M
KM
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D004854:Herpesvirus 4, Human / Q000502:physiology*; D006689:Hodgkin Disease / Q000473:pathology / Q000821:virology*; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008297:Male; D008875:Middle Aged; D009336:Necrosis