Microfibrils from the arterial subendothelium.
Microfibrillar structures of the subendothelium are represented by either type VI collagen or elastin-associated microfibrils which are also referred to as fibrillin-containing microfibrils. These structures are present throughout the subendothelium irrespective of the presence of elastin. The localization, structure, and protein composition of microfibrils are reviewed. The arterial subendothelium is thrombogenic despite its very low content in fibrillar collagens. This thrombogenicity is linked to the microfibrillar structures, essentially to type VI collagen and to thrombospondin-containing microfibrils. Their respective ability to bind the von Willebrand factor and to activate blood platelets is discussed.
Fauvel-Lafève
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Unité 353 INSERM, Institut d'Hématologie, Hôpital Saint-Louis, Paris, France.
D000818:Animals; D001158:Arteries / Q000737:chemistry / Q000648:ultrastructure; D001792:Blood Platelets / Q000502:physiology; D003094:Collagen / Q000502:physiology; D004730:Endothelium, Vascular / Q000737:chemistry* / Q000648:ultrastructure*; D006801:Humans; D009210:Myofibrils / Q000737:chemistry / Q000502:physiology* / Q000648:ultrastructure; D019699:Thrombospondins / Q000502:physiology; D014841:von Willebrand Factor / Q000502:physiology
D019699:Thrombospondins; D014841:von Willebrand Factor; D003094:Collagen