title: Cytotoxic effects of different concentrations of neutral and alkaline EDTA solutions used as root canal irrigants.
abstract: The cytotoxic effects of neutral and alkaline EDTA solutions were evaluated and compared with those of sodium hypochlorite solution using an established cell line: L929. Cytotoxicity was assessed by a quantitative technique at five observation periods (1, 3, 6, 12, and 24 h). All tested agents showed moderate to severe cytotoxicity in the present experimental model in a concentration-dependent manner.
authors: Department of Dental Pathology and Therapeutics, Dental School, Aristotle University, Thessaloniki, Greece.
authors: E A
authors: EA
authors: Koulaouzidou
authors: J
authors: J
authors: Margelos
authors: P
authors: P
authors: Beltes
authors: A H
authors: AH
authors: Kortsaris
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D004492:Edetic Acid / Q000633:toxicity*; D006863:Hydrogen-Ion Concentration; D007739:L Cells / Q000187:drug effects; D051379:Mice; D012388:Root Canal Irrigants / Q000633:toxicity*; D012973:Sodium Hypochlorite / Q000633:toxicity
chemical_list: D012388:Root Canal Irrigants; D004492:Edetic Acid; D012973:Sodium Hypochlorite