title: Mesomelic dysplasia with periosteal thickening, radio-humeral dislocation, osteoporosis and multiple fractures.
abstract: We report a boy with a new form of mesomelic dysplasia characterised by short stature, multifocal periosteal thickening, radio-humeral dislocation, osteoporosis and multiple fractures with minimal trauma. Electrophoresis of fibroblast collagens detected defects in type III and type V collagen.
  
  
  CONCLUSIONS
  Bone dysplasias presenting with osteopenia, abnormal trabecular pattern, bone fragility, and periosteal thickening suggest a collagenopathy. A possible collagen defect requires biochemical investigations.
authors: Department of Radiology, Royal Alexandra Hospital for Children, Sydney, Australia.
authors: K
authors: K
authors: Kozlowski
authors: J
authors: J
authors: Masel
mesh_terms: D000015:Abnormalities, Multiple; D001848:Bone Diseases, Developmental; D001851:Bone Diseases, Metabolic; D004392:Dwarfism; D004551:Elbow Joint; D006801:Humans; D007231:Infant, Newborn; D004204:Joint Dislocations; D008297:Male; D010024:Osteoporosis; D010522:Periostitis