The p21-Ras signal transduction pathway and growth regulation in human high-grade gliomas.
Deregulated p21-Ras function, as a result of mutation, overexpression or growth factor-induced overactivation, contributes to at least 30% of human cancer. This article reviews the potential role of the p21-Ras family of GTPases in the regulation of growth of high-grade gliomas and describes how targeting this oncoprotein clinically may provide a novel strategy to counteract glioma proliferation. The application of strategies directed at selectively opposing the deregulated signal transduction pathway of high-grade gliomas may be of potential therapeutic benefit and may offer a whole new arsenal of antineoplastic agents to be included in the multimodal treatment of these challenging neoplasms.
Bredel
M
M
Department of Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Pollack
I F
IF
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D001932:Brain Neoplasms / Q000473:pathology*; D005910:Glioma / Q000473:pathology*; D006801:Humans; D015689:Oncogene Protein p21(ras) / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D015689:Oncogene Protein p21(ras)