Formation of ondansetron polymorphs.
We used differential scanning calorimetry, infrared spectrophotometry and 1H nuclear magnetic resonance imaging to search for polymorphs of ondansetron. Samples were tested under different conditions of temperature, pulverization and pH, and in different solvents. The factors identified as able to cause the formation of polymorphs were heating to different temperatures for different times, and the use of ethanol and methanol as solvents.
Llácer
J M
JM
Department of Pharmacy and Pharmaceutical Technology, University of Granada, Spain.
Gallardo
V
V
Parera
A
A
Ruiz
M A
MA
D000932:Antiemetics / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D000431:Ethanol; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D008279:Magnetic Resonance Imaging; D000432:Methanol; D017294:Ondansetron / Q000737:chemistry*; D012997:Solvents; D013055:Spectrophotometry, Infrared
D000932:Antiemetics; D012997:Solvents; D000431:Ethanol; D017294:Ondansetron; D000432:Methanol