title: Dopamine D1 receptor gene polymorphism and schizophrenia in Japan.
abstract: We studied the relationship between schizophrenia and the DdeI polymorphism in the 5' untranslated region (5'UTR) of the dopamine D1 receptor (DRD1) gene. This polymorphism is an A (A1 allele) to G (A2 allele) transition in the 5' UTR of exon 2 at bp -48 (A-48G). One hundred forty-eight schizophrenics and 148 control subjects were investigated. No significant differences in genotypic counts and allele frequencies between schizophrenics and controls were found. Although a significant difference between the patients classified as disorganized type and the controls was discovered both in genotypic counts and allele frequencies, neither association proved significant when a Bonferroni correction was used. Moreover, there were no differences in scores of main symptoms of schizophrenia based on the Manchester Scale between patients with A1/A1 genotype and those with A1/A2 genotype. These findings suggest that this gene may not be involved in the pathogenesis of schizophrenia.
authors: Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors: H
authors: H
authors: Kojima
authors: O
authors: O
authors: Ohmori
authors: T
authors: T
authors: Shinkai
authors: T
authors: T
authors: Terao
authors: T
authors: T
authors: Suzuki
authors: K
authors: K
authors: Abe
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D005260:Female; D005838:Genotype; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D017447:Receptors, Dopamine D1 / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D017447:Receptors, Dopamine D1