Fragile X premutation is a significant risk factor for premature ovarian failure: the International Collaborative POF in Fragile X study--preliminary data.
The preliminary results of an international collaborative study examining premature menopause in fragile X carriers are presented. A total of 760 women from fragile X families was surveyed about their fragile X carrier status and their menstrual and reproductive histories. Among the subjects, 395 carried a premutation, 128 carried a full mutation, and 237 were noncarriers. Sixty-three (16%) of the premutation carriers had experienced menopause prior to the age of 40 compared with none of the full mutation carriers and one (0.4%) of the controls. Based on these preliminary data, there is a significant association between fragile X premutation carrier status and premature menopause.
Allingham-Hawkins
D J
DJ
dallingh@nygh.on.ca
Babul-Hirji
R
R
Chitayat
D
D
Holden
J J
JJ
Yang
K T
KT
Lee
C
C
Hudson
R
R
Gorwill
H
H
Nolin
S L
SL
Glicksman
A
A
Jenkins
E C
EC
Brown
W T
WT
Howard-Peebles
P N
PN
Becchi
C
C
Cummings
E
E
Fallon
L
L
Seitz
S
S
Black
S H
SH
Vianna-Morgante
A M
AM
Costa
S S
SS
Otto
P A
PA
Mingroni-Netto
R C
RC
Murray
A
A
Webb
J
J
Vieri
F
F
D000293:Adolescent; D000328:Adult; D005260:Female; D005600:Fragile X Syndrome; D006579:Heterozygote; D006801:Humans; D007391:International Cooperation; D008593:Menopause; D008597:Menstrual Cycle; D008875:Middle Aged; D016649:Primary Ovarian Insufficiency; D012307:Risk Factors