FHL-1/reconectin: a human complement and immune regulator with cell-adhesive function.
A novel regulator of the alternative complement pathway with functions similar to that of factor H has been identified in human plasma. The cDNA encoding this factor H-like protein 1 (FHL-1/reconectin) was isolated several years ago. Here, Peter Zipfel and Christine Skerka describe functional analyses revealing that this novel complement regulatory protein forms a molecular link between immune defense and cell adhesion.
Zipfel
P F
PF
Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany. zipfel@uke.uni-hamburg.de
Skerka
C
C
D000818:Animals; D020134:Catalytic Domain / Q000502:physiology; D002448:Cell Adhesion; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D017242:Complement Factor H / Q000235:genetics / Q000502:physiology*; D003170:Complement Pathway, Alternative; D006801:Humans; D013297:Streptococcus pyogenes / Q000378:metabolism / Q000472:pathogenicity
C493495:CFH protein, human; D017242:Complement Factor H