Practical applications of immunohistochemistry in hematolymphoid neoplasms.
Immunohistochemistry plays a key role in the diagnosis and classification of hematolymphoid neoplasms. New cell and lineage markers are constantly being discovered and added to the existing long list of antibodies. In this review article we provide general information and new applications of the commonly used hematolymphoid markers. We also discuss the features and applications of some newly discovered markers, such as ALK, fascin, granzyme/perforin, and tryptase. There is no universal "panel" for the diagnosis of hematolymphoid neoplasms. However, in this review article, we provide suggested panels for a given hematolymphoid neoplasm that is based on our experience and that reported in the literature.
Chu
P G
PG
Division of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA.
Chang
K L
KL
Arber
D A
DA
Weiss
L M
LM
D015703:Antigens, CD / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D016591:Histocytological Preparation Techniques; D006801:Humans; D007124:Immunoenzyme Techniques / Q000379:methods*; D016130:Immunophenotyping; D007938:Leukemia / Q000145:classification / Q000175:diagnosis* / Q000378:metabolism; D008223:Lymphoma / Q000737:chemistry / Q000145:classification / Q000175:diagnosis*; D010641:Phenotype
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor