title: RGS proteins: more than just GAPs for heterotrimeric G proteins.
abstract: Members of the newly described RGS family of proteins have a common RGS domain that contains GTPase-activating activity for many Galpha subunits of heterotrimeric G proteins. Their ability to dampen signalling via Galphai-, Galphaq- and Galpha12/13-coupled pathways makes them crucial players in mediating the multitude of cellular processes controlled by heterotrimeric G proteins. Some RGS proteins also contain additional motifs that link them to other signalling networks, where they constitute effector-type molecules. This review summarizes recent findings on RGS proteins, especially those that implicate RGS proteins in more than just enhancing the GTPase activity of their Galpha subunit targets.
authors: Division of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA. ldevries@ucsd.edu
authors: L
authors: L
authors: De Vries
authors: M
authors: M
authors: Gist Farquhar
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D000072261:Dishevelled Proteins; D004331:Drosophila melanogaster / Q000378:metabolism; D020558:GTP Phosphohydrolases / Q000378:metabolism*; D019204:GTP-Binding Proteins / Q000502:physiology*; D020690:GTPase-Activating Proteins; D046911:Macromolecular Substances; D008322:Mammals / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D008954:Models, Biological; D005810:Multigene Family; D009928:Organ Specificity; D010750:Phosphoproteins / Q000502:physiology; D011487:Protein Conformation; D011506:Proteins / Q000145:classification / Q000502:physiology*; D051381:Rats; D015398:Signal Transduction / Q000502:physiology*; D013329:Structure-Activity Relationship; D013347:Subcellular Fractions / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000072261:Dishevelled Proteins; D020690:GTPase-Activating Proteins; D046911:Macromolecular Substances; D008565:Membrane Proteins; D010750:Phosphoproteins; D011506:Proteins; D020558:GTP Phosphohydrolases; D019204:GTP-Binding Proteins