title: Low frequency of germline E-cadherin mutations in familial and nonfamilial gastric cancer.
abstract: Little is known about the relative contributions of genetic and environmental factors to the development of gastric cancer. Mutations in the cell adhesion molecule E-cadherin are recognized to be associated with the development of undifferentiated, diffuse and invasive gastric cancers. A recent study of two gastric cancer families has shown that germline mutations in the E-cadherin gene can be causative (Guilford P et al, Nature 1998; 26: 402-405). We have examined the E-cadherin gene for constitutive mutations in a systematic series of 106 gastric cancer patients, 10 with a family history of the disease and 96 sporadic cases. No pathogenic mutations were observed in any of the 106 patients. The results indicate that germline mutations in E-cadherin will not account for more than 3% of gastric cancers.
authors: Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK.
authors: J
authors: J
authors: Stone
authors: S
authors: S
authors: Bevan
authors: D
authors: D
authors: Cunningham
authors: A
authors: A
authors: Hill
authors: N
authors: N
authors: Rahman
authors: J
authors: J
authors: Peto
authors: A
authors: A
authors: Marossy
authors: R S
authors: RS
authors: Houlston
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology / Q000235:genetics*; D015820:Cadherins / Q000235:genetics*; D004782:Environmental Health; D005260:Female; D018095:Germ-Line Mutation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D013274:Stomach Neoplasms / Q000209:etiology / Q000235:genetics*
chemical_list: D015820:Cadherins