[Noradrenaline synthesis during the first week of life and development of inherited stress-induced arterial hypertension in rats].
Increasing of the noradrenaline synthesis with daily i.p. administration of synthetic noradrenaline precursor DL-Threo on the 21-25th day of life of the rats with inherited stress-induced arterial hypertension (ISIAH) resulted in a drop of basal and stress-induced blood pressure in adult animals with no changes in response of the hypothalamic-pituitary-adrenocortical system (HPAS). Reduction of the noradrenaline synthesis with daily i.p. administration of dopamine-hydroxylase inhibitor FLA-57 in 21-25th day old Wistar rats induced no arterial hypertension in adults but decreased their adrenocortical response to emotional stress. Noradrenaline deficit in the brain structures on the 4th week of life in rats seems to be associated with arterial hypertension only in presence of genetic defect determining this pathology. Changes in adult HPAS function due to shortage of noradrenaline in the brain in the end of the 1st month of life do not depend on hypertension.
Maslova
L N
LN
Institute of Cytology and Genetics of the Russian Acad. Sci., Siberian Branch, Novosibirsk, Russia.
Bulygina
V V
VV
Markel'
A L
AL
D000818:Animals; D001381:Azepines / Q000494:pharmacology; D001794:Blood Pressure; D004299:Dopamine beta-Hydroxylase / Q000037:antagonists & inhibitors; D015103:Droxidopa / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006973:Hypertension / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D009638:Norepinephrine / Q000096:biosynthesis* / Q000172:deficiency; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity; D013315:Stress, Psychological / Q000378:metabolism / Q000503:physiopathology
D001381:Azepines; D004791:Enzyme Inhibitors; C015590:4-methyl-1-homopiperazinedithiocarboxylic acid; D004299:Dopamine beta-Hydroxylase; D015103:Droxidopa; D009638:Norepinephrine