title: Recurrent macular corneal dystrophy type II 49 years after penetrating keratoplasty.
abstract: Recurrence of macular corneal dystrophy after keratoplasty is rare. We report light microscopic, immunohistochemical, electron microscopic, and serologic findings in a 78-year-old woman who underwent regrafting 49 years following the first penetrating keratoplasty. Examination of the corneal button revealed deposits of glycosaminoglycans in the graft beneath the Bowman layer, throughout the stroma, and in the endothelium with positive staining for antigenic keratan sulfate. By transmission electron microscopy, intracellular and extracellular deposits of a fibrillogranular material were detected in the stroma, Descemet membrane, and endothelium. The serum level of antigenic keratan sulfate was normal. Our findings indicate that macular corneal dystrophy type II may show late recurrence after penetrating keratoplasty with intense deposition of antigenic keratan sulfate in all corneal layers.
authors: Department of Ophthalmology and University Eye Hospital, University of Erlangen-Nürnberg, Erlangen, Germany.
authors: M
authors: M
authors: Küchle
authors: C
authors: C
authors: Cursiefen
authors: D C
authors: DC
authors: Fischer
authors: U
authors: U
authors: Schlötzer-Schrehardt
authors: G O
authors: GO
authors: Naumann
mesh_terms: D000368:Aged; D003315:Cornea / Q000378:metabolism / Q000601:surgery / Q000648:ultrastructure*; D003317:Corneal Dystrophies, Hereditary / Q000209:etiology* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007632:Keratan Sulfate / Q000378:metabolism; D015948:Keratoplasty, Penetrating / Q000009:adverse effects*; D012008:Recurrence; D012086:Reoperation
chemical_list: D007632:Keratan Sulfate