Simple one-pot synthesis of a 2'-tritium labeled C-deoxynucleoside.
The deoxygenation and 2'-labeling of a C-ribonucleoside by reductive elimination with tri-n-butyltin hydride[3H] in a one-pot reaction is described. The approach is a safe, simple, efficient, and general method for 2'-labeling of nucleosides.
Lutz
S
S
Department of Chemistry, University of Florida, Gainesville 32611, USA.
Benner
S A
SA
D003853:Deoxyribonucleosides / Q000138:chemical synthesis*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D014316:Tritium / Q000737:chemistry
D003853:Deoxyribonucleosides; D019275:Radiopharmaceuticals; D014316:Tritium