The human HLA-A*0201 allele, expressed in hamster cells, is not a high-affinity receptor for adenovirus type 5 fiber.
The coxsackie B virus and adenovirus receptor (CAR) and the major histocompatibility complex (MHC) class I alpha2 domain have been identified as high-affinity cell receptors for adenovirus type 5 (Ad5) fiber. In this study we show that CAR but not MHC class I allele HLA-A*0201 binds to Ad5 with high affinity when expressed on hamster cells. When both receptors are coexpressed on the cell surface of hamster cells, Ad5 fiber bind to a single high-affinity receptor, which is CAR.
Davison
E
E
Department of Respiratory Medicine & Allergy, The Guy's, King's College and St. Thomas' Hospitals School of Medicine, Thomas Guy House, Guy's Hospital, London SE1 9RT, United Kingdom.
Kirby
I
I
Elliott
T
T
Santis
G
G
D000260:Adenoviruses, Human / Q000378:metabolism*; D000483:Alleles; D000818:Animals; D016466:CHO Cells; D002213:Capsid / Q000378:metabolism*; D036022:Capsid Proteins; D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein; D006224:Cricetinae; D015870:Gene Expression; D015789:HLA-A2 Antigen / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D011991:Receptors, Virus / Q000235:genetics / Q000378:metabolism
C568771:CLMP protein, human; D036022:Capsid Proteins; D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein; D015789:HLA-A2 Antigen; D011991:Receptors, Virus; C018315:hexon capsid protein, Adenovirus