title: [Spectrum of neurological symptoms in dissections of brain-supplying arteries].
abstract: OBJECTIVE
  Dissection of extracranial arteries that supply the brain is a common cause of ischemic stroke in youngish persons. Yet this disease, with its warning and early symptoms, is inadequately known among the population as well as doctors. This study was undertaken to demonstrate the incidence, severity and sequelae of this condition, important in both routine general and hospital practice, with particular emphasis on early signs and diagnosis.
  
  
  METHODS
  The data from 33 patients (20 men, 13 women, average age 42 [21-72] years) who during one year had been treated in the authors' hospital for carotid (n = 23) or vertebral (n = 10) artery dissection were analysed.
  
  
  RESULTS
  The admission diagnosis of dissection, based on the history and ultrasound findings was in almost all cases confirmed by magnetic resonance imaging (wall haematoma), magnetic resonance angiograhy, computed tomography-angiography or conventional angiography. Typical warning and early symptoms such as whiplash sensation unilateral pain in the throat, neck and head or Horner's syndrome were elicited in nearly 50% of patients, while known causes such as trauma or connective tissue disease were confirmed in only 27%. Neurological deficits of ischemic infarction, some of them severe, persisted in two-thirds of patients, brain death occurred in one.
  
  
  CONCLUSIONS
  Dissection of carotid or vertebral arteries is a statistically and medically relevant cause of stroke in youngish persons that can be diagnosed by attention to typical warning and early symptoms and the performance of noninvasive tests. The often life-threatening sequelae of possible cerebral ischemia can be diagnosed and even averted by early recognition of the cause.
authors: Neuroradiologische Klinik, Ruprecht-Karls-Universität Heidelberg. markus_bertram@ukl.uni-heidelberg.de
authors: M
authors: M
authors: Bertram
authors: P
authors: P
authors: Ringleb
authors: J
authors: J
authors: Fiebach
authors: E
authors: E
authors: Orberk
authors: T
authors: T
authors: Brandt
authors: W
authors: W
authors: Hacke
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000784:Aortic Dissection / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology; D001921:Brain / Q000098:blood supply*; D002545:Brain Ischemia / Q000175:diagnosis / Q000209:etiology; D002340:Carotid Artery Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology; D002343:Carotid Artery, Internal; D002533:Cerebral Angiography; D002544:Cerebral Infarction / Q000175:diagnosis / Q000209:etiology; D002561:Cerebrovascular Disorders / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013997:Time Factors; D018616:Ultrasonography, Doppler, Duplex; D014711:Vertebral Artery / Q000000981:diagnostic imaging