[Interactions between naltrexone, an opioid antagonist, and opioids administered during general anesthesia].
We report a case of a probable interaction between sufentanil and naltrexone, an oral long acting opioid antagonist, prescribed for maintenance of abstinence in alcoholics and opioid addicts. The interaction resulted in an antagonisation of the effects of sufentanil and the necessity to increase the dosage. Anaesthetists should be aware of this potential drug interaction.
Tesson
B
B
Département d'anesthésie-réanimation chirurgicale, CHRU, Angers, France.
Bigot-Viale
A
A
Vigue
J P
JP
Pierrot
M
M
Granry
J C
JC
D000437:Alcoholism / Q000534:rehabilitation*; D000701:Analgesics, Opioid / Q000008:administration & dosage; D000771:Anesthesia, Intravenous; D018686:Anesthetics, Intravenous / Q000008:administration & dosage; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D009271:Naltrexone / Q000627:therapeutic use*; D009292:Narcotic Antagonists / Q000627:therapeutic use*; D019966:Substance-Related Disorders / Q000534:rehabilitation*; D017409:Sufentanil / Q000008:administration & dosage
D000701:Analgesics, Opioid; D018686:Anesthetics, Intravenous; D009292:Narcotic Antagonists; D009271:Naltrexone; D017409:Sufentanil