Endoscopic Nd:YAG laser therapy for villous adenomas of the right colon.
BACKGROUND
Endoscopic laser therapy is considered an acceptable treatment of benign colorectal adenomas. The aim of our study was to evaluate the efficacy of Nd:YAG laser to ablate right-sided colonic sessile adenomas.


METHODS
Between January 1990 and February 1996, 56 patients underwent laser therapy because of high operative risk or refusal of surgery. Lesions were located as follows: cecum (23), ascending, (15), and hepatic flexure (18). Six patients (10.7%) had multiple polyps in the ascending colon. Histologic examination showed a tubulovillous pattern in 20 (35.7%) and a villous pattern in 36 (64.3%). Low-grade dysplasia was detected in 44 patients (78. 5%) and high-grade dysplasia in 12 (21.4%).


RESULTS
The number of laser sessions ranged between 1 and 6 (median 3) and complete ablation, histologically confirmed, was achieved in 49 cases (87.5%). Seven patients (12.5%) underwent surgery: 2 for incomplete tumor destruction, 3 because of invasive carcinoma on repeated biopsies. Two patients (3.6%) had complications (one perforation of the cecum and one hemorrhage). Follow-up ranged from 6 to 60 months and no recurrences were observed.


CONCLUSIONS
Laser therapy is an effective method for the destruction of sessile adenomas of the right colon in selected patients.
Conio
M
M
Department of Gastroenterology, National Institute for Cancer Research, National Institute for Cancer Research, Genoa, Italy.
Caroli-Bosc
F X
FX
Filiberti
R
R
Dumas
R
R
Rouquier
P
P
Demarquay
J F
JF
Aste
H
H
Marchi
S
S
Delmont
J P
JP
D018253:Adenoma, Villous / Q000601:surgery*; D000368:Aged; D002430:Cecal Neoplasms / Q000601:surgery*; D003110:Colonic Neoplasms / Q000601:surgery*; D004724:Endoscopy / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017075:Laser Coagulation / Q000379:methods; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D013997:Time Factors