Novel role for E4 region genes in protection of adenovirus vectors from lysis by cytotoxic T lymphocytes.
Target cells infected with adenovirus (Ad) vectors containing intact E3 and E4 regions were found to be relatively resistant to lysis by Ad-specific cytotoxic T lymphocytes. Elements from both the E3 and the E4 regions were required for this effect, leading to the identification of a previously undescribed role for E4 gene products in resistance to cytolysis.
Kaplan
J M
JM
Genzyme Corporation, Framingham, Massachusetts 01701-9322, USA. jkaplan@genzyme.com
Armentano
D
D
Scaria
A
A
Woodworth
L A
LA
Pennington
S E
SE
Wadsworth
S C
SC
Smith
A E
AE
Gregory
R J
RJ
D017503:Adenovirus E3 Proteins / Q000276:immunology; D017504:Adenovirus E4 Proteins / Q000235:genetics / Q000276:immunology*; D000260:Adenoviruses, Human / Q000276:immunology*; D000818:Animals; D005260:Female; D005822:Genetic Vectors / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000276:immunology / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D017503:Adenovirus E3 Proteins; D017504:Adenovirus E4 Proteins; D007371:Interferon-gamma