title: Serotonin-containing cell bodies in novel brain locations: effects of light input.
abstract: Cell bodies staining positively for serotonin (5HT) appear in the suprachiasmatic nuclei (SCN) of hamsters that have been held in constant darkness (DD) for several months but are otherwise untreated. No such cell bodies are found in the SCN of animals that have been bilaterally enucleated for the same amount of time; however, in enucleated hamsters 5HT-containing cell bodies appear in the superior colliculus. These data provide the first indication that changes in sensory input can modulate 5HT levels in cells bodies outside of the raphe nuclei.
authors: Department of Biology and NSF Center for Biological Timing, University of Virginia, Charlottesville 22903, USA.
authors: S
authors: S
authors: Yamazaki
authors: V
authors: V
authors: Alones
authors: W
authors: W
authors: Irelan
authors: M
authors: M
authors: Menaker
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism*; D006224:Cricetinae; D003624:Darkness; D015353:Eye Enucleation; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D008647:Mesocricetus; D009474:Neurons / Q000378:metabolism*; D017440:Photoperiod; D011903:Raphe Nuclei / Q000166:cytology / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*; D013194:Staining and Labeling; D013477:Superior Colliculi / Q000166:cytology / Q000378:metabolism; D013493:Suprachiasmatic Nucleus / Q000166:cytology / Q000378:metabolism; D014018:Tissue Distribution / Q000502:physiology
chemical_list: D012701:Serotonin