Genotoxic potential of cyclosporin A in patients with renal transplantation.
We analyzed the induction of sister chromatid exchange (SCE) by cyclosporin A (CsA) as a marker of genotoxic potential. In 30 patients undergoing renal transplantation, SCE induction was tested before the introduction of CsA and 3 months later. We found that SCE frequency increased significantly at the end of 3 months. To our knowledge, this is the first study demonstrating in vivo induction of SCE by CsA in humans. We conclude that CsA has a genotoxic potential on human lymphocytes.
Palanduz
S
S
Istanbul Faculty of Medicine, Department of Internal Medicine, Branch of Medical Genetics, Turkey.
Sever
M S
MS
Oztürk
S
S
Taşçioğlu
C
C
Karan
M A
MA
Sönmez
G
G
Cefle
K
K
Güler
K
K
D000293:Adolescent; D000328:Adult; D002478:Cells, Cultured; D016572:Cyclosporine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D007166:Immunosuppressive Agents; D016572:Cyclosporine