title: Novel role for E4 region genes in protection of adenovirus vectors from lysis by cytotoxic T lymphocytes.
abstract: Target cells infected with adenovirus (Ad) vectors containing intact E3 and E4 regions were found to be relatively resistant to lysis by Ad-specific cytotoxic T lymphocytes. Elements from both the E3 and the E4 regions were required for this effect, leading to the identification of a previously undescribed role for E4 gene products in resistance to cytolysis.
authors: Genzyme Corporation, Framingham, Massachusetts 01701-9322, USA. jkaplan@genzyme.com
authors: J M
authors: JM
authors: Kaplan
authors: D
authors: D
authors: Armentano
authors: A
authors: A
authors: Scaria
authors: L A
authors: LA
authors: Woodworth
authors: S E
authors: SE
authors: Pennington
authors: S C
authors: SC
authors: Wadsworth
authors: A E
authors: AE
authors: Smith
authors: R J
authors: RJ
authors: Gregory
mesh_terms: D017503:Adenovirus E3 Proteins / Q000276:immunology; D017504:Adenovirus E4 Proteins / Q000235:genetics / Q000276:immunology*; D000260:Adenoviruses, Human / Q000276:immunology*; D000818:Animals; D005260:Female; D005822:Genetic Vectors / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000276:immunology / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
chemical_list: D017503:Adenovirus E3 Proteins; D017504:Adenovirus E4 Proteins; D007371:Interferon-gamma