Neurofibromatosis-Noonan syndrome and acute lymphoblastic leukemia: a report of two cases.
Two boys with neurofibromatosis-Noonan syndrome in whom acute lymphoblastic leukemia (ALL) developed are described. Both patients demonstrated B-lineage leukemias with normal cytogenetics. They were treated with combination chemotherapy and remain in remission off therapy. Patients with neurofibromatosis-Noonan syndrome may be at increased risk for ALL.
Klopfenstein
K J
KJ
Division of Hematology/Oncology, Columbus Children's Hospital, Ohio 43205, USA.
Sommer
A
A
Ruymann
F B
FB
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002675:Child, Preschool; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics; D016514:Genes, Neurofibromatosis 1; D011905:Genes, ras; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D017253:Neurofibromatoses / Q000150:complications* / Q000235:genetics; D025542:Neurofibromin 1; D009634:Noonan Syndrome / Q000150:complications* / Q000235:genetics; D010641:Phenotype; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000209:etiology*; D011506:Proteins / Q000502:physiology; D012074:Remission Induction; D012306:Risk
D025542:Neurofibromin 1; D011506:Proteins