title: Vertical transmission of Treponema pallidum to various litters and generations of guinea pigs.
abstract: The transmission of congenital syphilis was studied in a 4-generation guinea pig family with 10 litters and 38 offspring. By use of one or all of the following tests (ELISA-IgM, polymerase chain reaction, and rabbit infectivity), transplacental infection was demonstrated through 5 litters and up to 4 generations. Twenty-eight (93%) of 30 animals were positive by >/=1 test, and 2 (7%) were negative by 1 or 3 tests. While transmission of the pathogen appeared to be unaffected by the maternal acquisition of immunity, signs of smoldering infection in the young was suggested by the decline in humoral responses in successive progeny and by unusual rabbit infectivity test results. With each pregnancy there was a remarkable booster in the maternal humoral response, which dropped significantly prior to term. These findings shed new light on the understanding and interpretation of serologic testing during pregnancy and the perinatal period.
authors: Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany, NY 12201-0509, USA. wicherk@wadsworth.org.
authors: K
authors: K
authors: Wicher
authors: R E
authors: RE
authors: Baughn
authors: F
authors: F
authors: Abbruscato
authors: V
authors: V
authors: Wicher
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006168:Guinea Pigs; D007075:Immunoglobulin M / Q000097:blood; D018445:Infectious Disease Transmission, Vertical; D016133:Polymerase Chain Reaction / Q000379:methods; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology / Q000382:microbiology; D011817:Rabbits; D013587:Syphilis / Q000635:transmission*; D013590:Syphilis, Congenital / Q000276:immunology / Q000382:microbiology / Q000635:transmission*; D014210:Treponema pallidum / Q000276:immunology / Q000302:isolation & purification
chemical_list: D000907:Antibodies, Bacterial; D007075:Immunoglobulin M