Testicular seminoma in a patient with ataxia-telangiectasia.
The case history of a 27-year-old man with ataxia-telangiectasia (AT) and testicular seminoma is reported. This is the first documented description of such a malignancy in AT, a syndrome associated with a markedly increased risk of malignant disease. Furthermore, alpha-foetoprotein levels have limitations as a tumour marker in this situation because serum levels may be elevated as a biochemical manifestation of AT.
Phillips
H A
HA
Department of Clinical Oncology, Western General Hospitals NHS Trust, Edinburgh, UK.
Howard
G C
GC
D000328:Adult; D001260:Ataxia Telangiectasia / Q000150:complications*; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D018239:Seminoma / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D013736:Testicular Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D000509:alpha-Fetoproteins / Q000032:analysis
D000509:alpha-Fetoproteins