[Metabolism of the androgenic precursor androstenedione and effects of aromatase inhibitors in cultured blood lymphocytes].
Blood lymphocytes from 26 women were cultivated in RPMI-1640 for 72 hrs with or without dexamethasone, dbcAMP, and TPA. Androstenedione conversion was most often activated by the dbcAMP, then by Dex and TPA. Response to dbcAMP was most obvious in women under 50, whereas response to Dex--in women over 50. Aromatase inhibitor fadrosol displayed a tendency towards prevention of the activation of androstenedione conversion in cultivated lymphocytes. A possibility of aromatase gene induction in cultivated lymphocytes cannot be completely excluded and demands further investigation with the aid of molecular-genetic methods.
Bershteĭn
L M
LM
Petrov Research Institute of Oncology, St. Petersburg.
Poroshina
T E
TE
Larionov
A A
AA
Zimarina
T S
TS
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000735:Androstenedione / Q000378:metabolism*; D047072:Aromatase Inhibitors; D003994:Bucladesine / Q000494:pharmacology; D002478:Cells, Cultured; D003907:Dexamethasone / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D017316:Fadrozole / Q000494:pharmacology; D005260:Female; D006801:Humans; D000077289:Letrozole; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D008875:Middle Aged; D009570:Nitriles / Q000494:pharmacology; D014230:Triazoles / Q000494:pharmacology
D047072:Aromatase Inhibitors; D004791:Enzyme Inhibitors; D009570:Nitriles; D014230:Triazoles; D000735:Androstenedione; D003994:Bucladesine; D000077289:Letrozole; D003907:Dexamethasone; D017316:Fadrozole