Repeated exposure of rats to JP-4 vapor induces changes in neurobehavioral capacity and 5-HT/5-HIAA levels.
Thirty-two Sprague-Dawley rats were exposed for 6 h/d for 14 consecutive days to JP-4 jet fuel vapor (2 mg/L) or room air control conditions. Following a 14- or 60-d recovery period, rats completed a battery of 8 tests selected from the Navy Neurobehavioral Toxicity Assessment Battery (NTAB) to evaluate changes in performance capacity. Exposure to JP-4 vapor resulted in significant changes in neurobehavioral capacity on several tests that varied as a function of the duration of the recovery period. Rats were evaluated for major neurotransmitter and metabolite levels in five brain regions and in the blood serum. Levels of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) were shown to be significantly elevated in several brain regions as well as in the blood serum in the vapor-exposed groups. Results of the rat study are compared to previously reported neurobehavioral evaluations of European manufacturing personnel exposed chronically to jet fuel vapor.
Nordholm
A F
AF
Naval Health Research Institute Detachment-Toxicology, Wright-Patterson Air Force Base, Ohio, USA.
Rossi
J
J
Ritchie
G D
GD
McInturf
S
S
Hulme
M E
ME
McCool
C
C
Narayanan
L
L
MacMahon
K L
KL
Eggers
J
J
Leahy
H F
HF
Wolfe
R E
RE
D000221:Adaptation, Ocular / Q000187:drug effects; D000818:Animals; D001069:Appetite Regulation / Q000187:drug effects; D015415:Biomarkers / Q000097:blood; D001835:Body Weight; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004195:Disease Models, Animal; D004781:Environmental Exposure; D006838:Hydrocarbons / Q000008:administration & dosage / Q000633:toxicity*; D006897:Hydroxyindoleacetic Acid / Q000097:blood; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D017288:Pain Threshold / Q000187:drug effects; D010808:Physical Examination; D051381:Rats; D017207:Rats, Sprague-Dawley; D013216:Reflex, Startle / Q000187:drug effects; D012701:Serotonin / Q000097:blood
D015415:Biomarkers; D006838:Hydrocarbons; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; C029662:JP5 jet fuel