Antimitogenic effect of Larrea divaricata Cav.: participation in arachidonate metabolism.
Aqueous extracts of the leaves of Larrea divaricata Cav. exert antimitogenic effects on tumor cells (BW 5147 murine immature T-lymphoma) and normal, stimulated lymphocytes. The effective concentration was four times smaller in the case of tumor cells than in the case of normal, stimulated lymphocytes. Inhibitor studies of arachidonate pathway suggest that the proliferative effect of the extract is due to the activation of lipoxygenase metabolism, while the inhibitory action could be a direct effect.
Anesini
C
C
Cátedra de Farmacología, Facultad de Odontología, Universidad de Buenos Aires and Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Cientificas y Técnicas (CONICET), Argentina.
Genaro
A
A
Cremaschi
G
G
Sterin Borda
L
L
Borda
E
E
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D016718:Arachidonic Acid / Q000378:metabolism*; D002455:Cell Division / Q000187:drug effects; D003208:Concanavalin A / Q000494:pharmacology; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D004230:Dithizone / Q000494:pharmacology; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects; D016399:Lymphoma, T-Cell / Q000473:pathology; D009637:Masoprocol / Q000494:pharmacology; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves; D037121:Plant Lectins; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D016861:Cyclooxygenase Inhibitors; D016859:Lipoxygenase Inhibitors; D010936:Plant Extracts; D037121:Plant Lectins; D003208:Concanavalin A; D016718:Arachidonic Acid; D004230:Dithizone; D009637:Masoprocol