Signal transduction by a protease cascade.
The dorsoventral axis of the Drosophila embryo is determined by a spatial cue generated by ovarian somatic cells. This cue is communicated to the embryo through an extracellular serine protease cascade active only on the ventral side of the embryo. Studies of the proteases and somatically expressed proteins involved in this signalling process suggest a working model for how the protease cascade is locally activated hours after the ovarian somatic cells have degenerated.
LeMosy
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EK
Dept of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA.
Hong
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CC
Hashimoto
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D000818:Animals; D004330:Drosophila / Q000196:embryology; D029721:Drosophila Proteins; D010450:Endopeptidases / Q000378:metabolism*; D004789:Enzyme Activation; D019476:Insect Proteins / Q000378:metabolism; D008024:Ligands; D008562:Membrane Glycoproteins / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D012697:Serine Endopeptidases / Q000378:metabolism; D015398:Signal Transduction; D015238:Sulfotransferases / Q000378:metabolism; D051193:Toll-Like Receptors
D029721:Drosophila Proteins; D019476:Insect Proteins; D008024:Ligands; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; C068721:Tl protein, Drosophila; D051193:Toll-Like Receptors; C110185:wbl protein, Drosophila; D015238:Sulfotransferases; C115847:pip protein, Drosophila; D010450:Endopeptidases; D012697:Serine Endopeptidases; C115869:ndl protein, Drosophila