[Effect of local hypotensive therapy on ocular hemodynamics in patients with primary open-angle glaucoma].
Ocular hemodynamics is followed u p in patients with primary open-angle glaucoma after local application of 1% pilocarpine and 0.5% timolol maleate for 30 days. Forty-two patients (48 eyes) aged 47-82 years with initial, well-developed, and far-advanced condition were followed up. Diastolic, m ean dynamic pressure in the orbital artery, and perfusion pressure were measured. A significant decrease of diastolic pressure in the orbital artery, more expressed during the first ten days was observed in all patients. Later this value increased till the end of follow-up, but did not reach the initial level. Hence, patients with visual field loss are characterized by a higher local vascular tone and are less liable to its decrease after the above local hypotensive therapy.
Bakshinskiĭ
P P
PP
D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005123:Eye / Q000098:blood supply*; D005260:Female; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000188:drug therapy* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009880:Ophthalmic Artery / Q000503:physiopathology; D009883:Ophthalmic Solutions; D010277:Parasympathomimetics / Q000008:administration & dosage / Q000627:therapeutic use*; D010862:Pilocarpine / Q000008:administration & dosage / Q000627:therapeutic use*; D013999:Timolol / Q000008:administration & dosage / Q000627:therapeutic use*
D000959:Antihypertensive Agents; D009883:Ophthalmic Solutions; D010277:Parasympathomimetics; D010862:Pilocarpine; D013999:Timolol