Effects of exogenous [Arg8]-vasopressin on borderline-hypertensive Hiroshima rats.
The interaction between [Arg8]-vasopressin and a vasopressin receptor antagonist, [d(CH2)5(1), O-Me-Tyr2, Arg8]-vasopressin, was examined in Hiroshima rats and normotensive control rats under pentobarbital anesthesia. [Arg8]-vasopressin dose-dependently increased the arterial pressure in both the Hiroshima and control rats, the pressor effect being greater in the Hiroshima rats. After the administration of a vasopressin antagonist (0.01 mg/kg), which by itself decreased arterial pressure only in the Hiroshima rats, the dose-response curve for [Arg8]-vasopressin was much more greatly shifted to the right in the control rats. These results indicate that with or without a vasopressin antagonist, the exogenous [Arg8]-vasopressin induced more powerful pressor actions in the Hiroshima rats compared to the control rats.
Teranishi
Y
Y
Department of Physiology, Hiroshima University School of Medicine, Japan.
Kumazaki
T
T
Ozono
R
R
Tsuru
H
H
D000758:Anesthesia; D000818:Animals; D065092:Antidiuretic Hormone Receptor Antagonists; D001127:Arginine Vasopressin / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology; D051381:Rats
D065092:Antidiuretic Hormone Receptor Antagonists; D001127:Arginine Vasopressin; D010424:Pentobarbital