[The pharmacological correction of the hepatotoxic action of platidiam].
A single intravenous infusion of 4.5 mg/kg of the new antineoplastic drug platidium induces structural-metabolic changes in the liver of rats (necrosis of hepatocytes, decrease of the glycogen and RNA content and accumulation of lipids in the cytoplasm of the hepatic cells, and increased activity of aspartate- and alaninaminotransferase in blood serum). An additional toxic factor (CCl4) applied one month after platidium infusion revealed incompleteness of reparative processes in the liver. The hepatoprotector essentiale weakens the injurious effect of the cytostatic on the hepatocytes and stimulates regeneration of the liver.
Fomina
T I
TI
Institute of Pharmacology, Tomsk Research Center, Siberian Branch, Russian Academy of Medical Sciences, Russia.
Vetoshkina
T V
TV
Dubskaia
T Iu
TIu
D000208:Acute Disease; D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D002945:Cisplatin / Q000633:toxicity*; D003592:Cytophotometry; D004353:Drug Evaluation, Preclinical; D006651:Histocytochemistry; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008115:Liver Regeneration / Q000187:drug effects; D010713:Phosphatidylcholines / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000970:Antineoplastic Agents; D010713:Phosphatidylcholines; C011246:essential 303 forte; D002945:Cisplatin