[The effect of NC-1900: its ameliorating effects on impairments of learning and memory in the CA1 neurons and its intracellular signal transduction pathways].
Effects of arginine vasopressin (AVP(1-9)) and its analogues on the glycine (Gly)-induced Cl- currents (IGly) were examined in acutely dissociated rat hippocampal CA1 neurons using nystatin perforated and conventional whole-cell patch recording modes under voltage-clamp conditions. The results suggest that the activation of V1 receptor induces IP3 production which release Ca2+ from IP3-sensitive Ca2+ storage sites. The Ca2+ binds to CaM, resulting in the activation of Ca2+/CaM-sensitive adenylate cyclases. Consequently, the activation of PKA inhibits IGly. The inhibitory actions of NC-1900 and its analogues on IGly might be involved in their ameliorating effects on impairments of learning and memory in the CA1 neurons.
Akaike
N
N
Department of Physiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Ohmura
K
K
D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects; D007858:Learning / Q000187:drug effects*; D008568:Memory / Q000187:drug effects*; D051379:Mice; D009842:Oligopeptides / Q000494:pharmacology*; D017966:Pyramidal Cells / Q000187:drug effects; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D051381:Rats; D015398:Signal Transduction / Q000187:drug effects*
C115056:NC 1900; D009842:Oligopeptides; D001127:Arginine Vasopressin; D011761:Pyrrolidonecarboxylic Acid