title: Studies towards the identification of potent, selective and bioavailable thrombin inhibitors.
abstract: The application of selection criteria, based on potency and physicochemical parameters, to a candidate library of thrombin inhibitors is described. The utility of the approach is exemplified by the discovery of a potent, selective and bioavailable thrombin inhibitor 62.
authors: Novartis Horsham Research Center, West Sussex.
authors: J
authors: J
authors: Ambler
authors: E
authors: E
authors: Baker
authors: D
authors: D
authors: Bentley
authors: L
authors: L
authors: Brown
authors: K
authors: K
authors: Butler
authors: P
authors: P
authors: Butler
authors: D
authors: D
authors: Farr
authors: K
authors: K
authors: Dunnet
authors: D
authors: D
authors: Le Grand
authors: J
authors: J
authors: Hayler
authors: D
authors: D
authors: Janus
authors: D
authors: D
authors: Jones
authors: K
authors: K
authors: Menear
authors: M
authors: M
authors: Mercer
authors: G
authors: G
authors: Smith
authors: M
authors: M
authors: Talbot
authors: M
authors: M
authors: Tweed
mesh_terms: D000925:Anticoagulants / Q000302:isolation & purification / Q000493:pharmacokinetics / Q000494:pharmacology*; D001682:Biological Availability; D013329:Structure-Activity Relationship; D013917:Thrombin / Q000037:antagonists & inhibitors*
chemical_list: D000925:Anticoagulants; D013917:Thrombin