[The effect of L-arginine on the ultrastructure of atrial cardiomyocytes in experimental hypercholesterolemia].
The results of electronmicroscopic study of the right atrium in experimental hypercholesterolemia revealed a disturbance of ultrastructural organisation of both cardiomyocytes and endothelial cells of blood microvessels. Intake of L-arginine--a precursor of synthesis of nitric oxide (NO)--with atherogenic diet was found to prevent to some extent the damage of ultrastructural organisation of cardiomyocytes and to stimulate the production of atrial granules. A significant number of secretory components, which differ in terms of structure and function, revealed in the endothelium of blood microvessels may testify to the fact that upon administration of L-arginine the paracrine effect of hormonal regulation is enhanced manifesting itself through an increase of synthesis and secretion of natriuretic hormone in atrial cardiomyocytes. A tissue hormonal system is displayed through an increase of synthesis and secretion of atrial natriuretic hormone in cardiomyocytes. On the other hand, a NO precursor L-arginine may produce a correcting effect upon the ultrastructure of endotheliocytes in hypercholesterolemia.
Stechenko
L O
LO
A. A. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kiev.
Sahach
V F
VF
Tkachenko
M M
MM
Skybins'ka
T R
TR
Andriienko
T V
TV
D000818:Animals; D001120:Arginine / Q000494:pharmacology* / Q000627:therapeutic use; D002784:Cholesterol / Q000097:blood; D004036:Diet, Atherogenic; D004353:Drug Evaluation, Preclinical; D006321:Heart / Q000187:drug effects*; D006325:Heart Atria / Q000187:drug effects / Q000648:ultrastructure; D006937:Hypercholesterolemia / Q000097:blood / Q000209:etiology / Q000473:pathology* / Q000517:prevention & control; D008854:Microscopy, Electron; D009206:Myocardium / Q000648:ultrastructure*; D011817:Rabbits
D001120:Arginine; D002784:Cholesterol