title: [The usefulness of transjugular hepatic biopsy in the evaluation of liver disease in candidates for heart transplantation].
abstract: Heart transplantation is a universally accepted procedure in the treatment of terminal heart diseases. However, the presence of advanced liver disease in the potential receptors represents a contraindication for heart transplantation. On the other hand, the true diagnosis of liver disease not secondary to heart disease may be difficult requiring confirmatory liver biopsy. Nonetheless, percutaneous liver biopsy may be difficult to perform due to presence of coagulation alterations, marked dilatation of the hepatic veins, etc. The aim of this study was to evaluate the efficacy and safety of transjugular hepatic biopsy in the presence of severe coagulopathy in potential heart transplantation receptors with suspicion of liver disease and contraindication of percutaneous liver biopsy. Over a 9-year period, 350 potential heart transplantation patients were evaluated. In 23 patients (6.7%) transjugular hepatic biopsy was performed with aspiration needle followed by a hemodynamic study in 17 cases. The transjugular hepatic biopsy was completed in 22 cases (95.6%) with adequate material for the diagnosis being obtained in 21 (91.3% of the total cases indicated). Histologic study showed significant inflammatory infiltrates or alteration of the hepatic architecture in 4 patients (18%), all being positive for some viral markers (AgHBs or anti-HCV). The obtaining of a certain histologic diagnosis modified the consideration of liver disease as a definitive contraindication and allowed the performance of heart transplantation in 17 patients (73.9%). No complications were observed in association with the procedure. The transjugular hepatic biopsy is a feasible, effective and safe alternative for obtaining liver tissue in patients under evaluation for heart transplantation with suspicion of severe liver disease. The establishment of a correct histologic diagnosis may modify the clinical decision in an important number of patients.
authors: Laboratorio de Hemodinámica Hepática, Hospital General Universatario Gregorio Marañón Madrid.
authors: A
authors: A
authors: Parera
authors: R
authors: R
authors: Bañares
authors: R
authors: R
authors: Alvarez
authors: J
authors: J
authors: Casariego
authors: J A
authors: JA
authors: Carneros
authors: M
authors: M
authors: Salcedo
authors: J
authors: J
authors: Palomo
authors: E
authors: E
authors: Cos
mesh_terms: D001706:Biopsy / Q000379:methods*; D000075202:Contraindications; D005240:Feasibility Studies; D006331:Heart Diseases / Q000150:complications / Q000601:surgery; D016027:Heart Transplantation; D006801:Humans; D008107:Liver Diseases / Q000150:complications / Q000473:pathology*; D008875:Middle Aged; D018579:Patient Selection