CRBP I and CRABP I localisation during olfactory nerve development.
Retinoic acid appears to play a role during the formation of the olfactory system. Immunohistochemistry was used to localise the cellular retinoid binding-proteins for retinol (CRBP I) and retinoic acid (CRABP I) in the embryonic and adult olfactory system. Our results indicate that RA produced by the CRBP I-expressing 'glia-like' cells may act as a neurotrophic factor for the CRABP I-expressing immature olfactory axons.
Gustafson
A L
AL
Department of Pharmaceutical Bioscience, Division of Toxicology, Uppsala Biomedical Centre, Uppsala University, Box 594, 751 24, Uppsala, Sweden. annelee.gustafson@tox.uu.se
Eriksson
U
U
Dencker
L
L
D000818:Animals; D001369:Axons / Q000737:chemistry; D051379:Mice; D008810:Mice, Inbred C57BL; D009830:Olfactory Bulb / Q000737:chemistry / Q000166:cytology / Q000196:embryology; D009832:Olfactory Nerve / Q000737:chemistry* / Q000166:cytology / Q000196:embryology*; D018034:Olfactory Receptor Neurons / Q000737:chemistry / Q000502:physiology / Q000648:ultrastructure; D018168:Receptors, Retinoic Acid / Q000032:analysis*; D012177:Retinol-Binding Proteins / Q000032:analysis*; D054840:Retinol-Binding Proteins, Cellular; D014212:Tretinoin / Q000502:physiology
D018168:Receptors, Retinoic Acid; D012177:Retinol-Binding Proteins; D054840:Retinol-Binding Proteins, Cellular; C082927:retinoic acid binding protein I, cellular; D014212:Tretinoin