Effects of 2-phenoxyethanol on N-methyl-D-aspartate (NMDA) receptor-mediated ion currents.
The actions were examined of 17 frequently used glycol ether compounds on the glutamate receptor-mediated ion currents. The receptors were expressed in Xenopus oocytes by injection of rat brain mRNA. Most of the 17 glycol ethers exerted no effects on the glutamate subreceptors activated by kainate and N-methyl-D-aspartate (NMDA), whereas 2-phenoxyethanol (ethylene glycol monophenyl ether) caused a considerable reduction of NMDA-induced membrane currents in a reversible and concentration-dependent manner. The threshold concentration of the ethylene glycol monophenyl ether effect was < 10 mumol/l. The concentration for a 50% inhibition (IC50) was approximately 360 mumol/l. The results indicate a neurotoxic potential for 2-phenoxyethanol.
Musshoff
U
U
Institut für Physiologie, Universität Münster, Germany. mushoff@uni-muenster.de
Madeja
M
M
Binding
N
N
Witting
U
U
Speckmann
E J
EJ
D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005026:Ethylene Glycols / Q000494:pharmacology*; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D007473:Ion Channels / Q000187:drug effects* / Q000502:physiology; D007608:Kainic Acid / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects*; D016202:N-Methylaspartate / Q000494:pharmacology; D009865:Oocytes; D012333:RNA, Messenger / Q000008:administration & dosage; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000819:agonists / Q000502:physiology*; D014981:Xenopus
D000777:Anesthetics; D005026:Ethylene Glycols; D018690:Excitatory Amino Acid Agonists; D007473:Ion Channels; D012333:RNA, Messenger; D016194:Receptors, N-Methyl-D-Aspartate; D016202:N-Methylaspartate; C005398:phenoxyethanol; D007608:Kainic Acid