title: Preventing posterior capsule opacification by creating a discontinuous sharp bend in the capsule.
abstract: OBJECTIVE
  To clarify which factor--intraocular lens (IOL) design or material--contributes most to the inhibition of migrating lens epithelial cells (LECs).
  
  
  METHODS
  Jinshikai Medical Foundation, Nishi Eye Hospital, Osaka, Japan.
  
  
  METHODS
  After phacoemulsification, an acrylic IOL with sharp optic edges was implanted in 1 eye and a poly(methyl methacrylate) (PMMA) IOL with an optic design similar to that of the acrylic IOL in the contralateral eye of 4 rabbits.
  
  
  RESULTS
  The Miyake view and histopathological findings 3 weeks after surgery revealed that the lens capsule wrapped tightly around the optic edges, conforming to a distinctly sharp rectangular bend there with both IOL types in all rabbits. The migrating-LECs were inhibited at the site, and a massive Soemmering's ring cataract was formed.
  
  
  CONCLUSIONS
  The discontinuous sharp capsule bend created by the sharp optic edges in both IOL types appeared to induce contact inhibition of the migrating LECs. The preventive effect of an acrylic IOL on posterior capsule opacification may be design dependent.
authors: Nishi Eye Hospital, Osaka, Japan.
authors: O
authors: O
authors: Nishi
authors: K
authors: K
authors: Nishi
mesh_terms: D000180:Acrylic Resins; D000818:Animals; D002386:Cataract / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D002465:Cell Movement / Q000502:physiology; D002478:Cells, Cultured; D004847:Epithelial Cells / Q000502:physiology; D005500:Follow-Up Studies; D007903:Lens Capsule, Crystalline / Q000473:pathology*; D019654:Lens Implantation, Intraocular / Q000379:methods*; D007910:Lenses, Intraocular; D018918:Phacoemulsification / Q000009:adverse effects; D019904:Polymethyl Methacrylate; D011474:Prosthesis Design; D011817:Rabbits
chemical_list: D000180:Acrylic Resins; D019904:Polymethyl Methacrylate