Evidence for a polyclonal etiology of palmar fibromatosis.
X chromosome inactivation patterns at the androgen receptor locus were evaluated to determine clonality in microdissected lesional tissue and in leukocytes from 2 women with Dupuytren's disease. The tissue from both patients generated a polyclonal pattern of X chromosome inactivation of the human androgen receptor gene. This finding supports a polyclonal reactive process as the underlying etiology for palmar fibromatosis.
Chansky
H A
HA
Department of Orthopaedics, University of Washington School of Medicine, Seattle, USA.
Trumble
T E
TE
Conrad
E U
EU
Wolff
J F
JF
Murray
L W
LW
Raskind
W H
WH
D004303:Dosage Compensation, Genetic; D004387:Dupuytren Contracture / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D007962:Leukocytes; D008875:Middle Aged; D011944:Receptors, Androgen / Q000235:genetics*; D015183:Restriction Mapping
D011944:Receptors, Androgen