title: Adenosine, the anxiolytic-like principle of the Arillus of Euphoria longana.
abstract: According to traditional usage, the extract of Longan Arillus was tested for its anxiolytic-like effect by application of the Vogel-type anti-conflict method in mice. The extract indicated significant activity at a dose of 2 g/kg, s.c., and results of the bioassay-oriented isolation revealed adenosine to be the active principle. Adenosine produced the anti-conflict effect significantly at a dose of 30 mg/kg, s.c. Adenine, uridine, and 5-methyluridine did not exhibit the effect, although these compounds were isolated from the extract. Some other related compounds such as AMP and c-AMP showed no effect, except for inosine. Adenosine also contributed to the analgesic effect which was observed in the extract by the writhing method.
authors: Faculty of Pharmaceutical Sciences, Chiba University, Japan. emi@p.chiba.u.ac.jp
authors: E
authors: E
authors: Okuyama
authors: H
authors: H
authors: Ebihara
authors: H
authors: H
authors: Takeuchi
authors: M
authors: M
authors: Yamazaki
mesh_terms: D000241:Adenosine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001007:Anxiety / Q000139:chemically induced*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D014151:Anti-Anxiety Agents; D000241:Adenosine