[The effect of shear stress on vascular endothelium].
Effects of shear stress on intracellular Ca2+ concentration ([Ca2+]i) and membrane potential of intact endothelium of the rat aorta have been investigated. Shear stress and acethylcholine both evoked endothelium-dependent relaxation of the rat aorta, but in contrast to acethylcholine shear stress did not affect [Ca2+]i and membrane potential of the endothelium. These data do not corroborate the hypotheses on involvement of Ca2+ and membrane potential in reception of shear stress by endothelium.
Marchenko
S M
SM
Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000502:physiology; D002118:Calcium / Q000502:physiology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D051381:Rats; D013314:Stress, Mechanical; D014665:Vasodilator Agents / Q000494:pharmacology
D014665:Vasodilator Agents; D000109:Acetylcholine; D002118:Calcium