[Active oxygen metabolites in provision and control of natural cytotoxic reactions].
Whether the redox active compounds that are able to generate and capture free oxygen radicals utilized in natural cytotoxicity (NCT) are involved in the provision and control of NCT in the body of man and animals is discussed. Evidence is given for the participation of endogenous metal-binding peptido(proteo)glycans (MBPPG) in the establishment and maintenance of regulatory balance in the complex of NCT reactions. Cyanobacterial exometabolites and their related metal-binding amphipathic compounds yielded in the exosystem was substantiated to be involved in the rational limitation of lymphocytic cytotoxicity. The findings suggest that exogenous redox active microbial products exert their action on NCT cells by changing the rate of generation and capture of free oxygen radicals by exogenous MBPPG.
Cheknev
S B
SB
D000818:Animals; D001665:Binding Sites; D003602:Cytotoxicity, Immunologic / Q000502:physiology*; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism; D010084:Oxidation-Reduction; D017382:Reactive Oxygen Species / Q000378:metabolism*
D017382:Reactive Oxygen Species