title: Isometric torque about the knee joint generated by microstimulation of the cat L6 spinal cord.
abstract: Isometric torque was generated about the knee joint by microstimulation of the cat L6 spinal cord using a single microelectrode. The torque responses varied with microstimulation location. Appreciable extension torque was generated by microstimulation in ventrolateral locations of the L6 spinal cord. Stimulation parameters (intensity, frequency and pulse-width) also influenced the extension torque. Specific stimulation parameters (100 microA intensity, 40 Hz frequency and 0.20 ms pulse-width) appear best suited for mapping the spinal cord based on knee joint torque responses. Low levels of cocontraction of the extensor and flexor could be achieved when extension torque was produced, but also varied with the stimulation locations. There are locations in the L6 ventral horn where microstimulation could evoke sustained extension for at least 4 min with only a slight change in torque. This study suggests the possibility of restoring lower limb function in patients with spinal cord injury above the lumbar level.
authors: Department of Pharmacology, University of Pittsburgh, PA 15261, USA.
authors: C
authors: C
authors: Tai
authors: A M
authors: AM
authors: Booth
authors: C J
authors: CJ
authors: Robinson
authors: W C
authors: WC
authors: de Groat
authors: J R
authors: JR
authors: Roppolo
mesh_terms: D000818:Animals; D002415:Cats; D004599:Electric Stimulation Therapy; D004567:Electrodes, Implanted; D004576:Electromyography; D006614:Hindlimb / Q000503:physiopathology*; D007537:Isometric Contraction / Q000502:physiology*; D007719:Knee Joint / Q000503:physiopathology*; D008297:Male; D008839:Microelectrodes; D018763:Muscle Fatigue; D018482:Muscle, Skeletal / Q000503:physiopathology; D013116:Spinal Cord / Q000473:pathology; D013119:Spinal Cord Injuries / Q000534:rehabilitation*