DNA-protein cross-links in cells of internal organs of rats after fractional irradiation at various doses.
The influence of daily fractional irradiation of male Wistar rats for 30 days on DNA-protein cross-links (DPC) in spleen, thymus, and liver cells was studied. The level of DPC depended strongly on the daily dose of irradiation and the studied organ. After irradiation at dose 0.5 Gy per day increased DPC level was detected in all organs. The highest level was in the lymphoid organs and the lowest in the liver. After irradiation at dose 0.3 Gy per day DPC formation was detected only in the thymus. The data suggest the existence of a dose threshold for DPC formation during fractional irradiation.
Grigoryev
M V
MV
Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology, Moscow, 109472, Russia. stronzy@openmail.irex.ru.
Kolomijtseva
G Y
GY
Puchkov
P V
PV
D000818:Animals; D004247:DNA / Q000528:radiation effects*; D004249:DNA Damage; D019583:Dose Fractionation, Radiation; D008099:Liver / Q000378:metabolism / Q000528:radiation effects; D008297:Male; D011506:Proteins / Q000528:radiation effects*; D011829:Radiation Dosage; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000378:metabolism / Q000528:radiation effects; D013950:Thymus Gland / Q000378:metabolism / Q000528:radiation effects
D011506:Proteins; D004247:DNA