Allelic variants of dopamine receptor D4 (DRD4) and serotonin receptor 5HT2c (HTR2c) and temperament factors: replication tests.
The contribution of genetic factors to personality differences between individuals is evidenced by twin and adoption studies. Ebstein et al. [1996, 1997a, 1997b] reported an association between the long repeat allele of the dopamine D4-exon-III receptor polymorphism and the human personality dimension novelty seeking (NS), between the 5HT2c-ser-23 allele and reward dependence, and an interaction between both receptor polymorphisms and reward dependence. Subsequent replication tests mainly reported controversial results for the association between DRD4-exon-III long repeat and NS. We examined a homogeneous study population of 190 healthy male students of middle European descent, aged between 20 and 30 years using Cloninger's TPQ in order to replicate Ebstein's findings. Using a significance level of 1%, no association between the long repeat of the DRD4-exon-III polymorphism and NS and between the 5HT2c receptor polymorphism and reward dependence was found, but a significant interaction effect of DRD4 and 5HT2c receptor polymorphisms on reward dependence was observed in accordance to Ebstein's report.
Kühn
K U
KU
Department of Psychiatry, University of Bonn, Germany.
Meyer
K
K
Nöthen
M M
MM
Gänsicke
M
M
Papassotiropoulos
A
A
Maier
W
W
D000328:Adult; D000704:Analysis of Variance; D005106:Exploratory Behavior; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D010551:Personality; D010556:Personality Tests; D044405:Receptor, Serotonin, 5-HT2C; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D050638:Receptors, Dopamine D4; D011985:Receptors, Serotonin / Q000235:genetics*; D012201:Reward
C493599:DRD4 protein, human; D044405:Receptor, Serotonin, 5-HT2C; D017448:Receptors, Dopamine D2; D011985:Receptors, Serotonin; D050638:Receptors, Dopamine D4