[Physicochemical aspects of cataract genesis].
Based on their own studies and the data available in the literature, the authors consider the physicochemical aspects of cataract genesis. Emphasis is laid on the role of oxidative stress in this diseases. It is suggested that one of the key mechanisms of cataract genesis is the exhausted lenticular potential and oxidative stress, resulting in the formation of products that enhance lenticular photo lesion and imbalance of cyclonucleotide- and Ca(2+)-dependent cascade systems of regulation, which leas to impaired cAMP-dependent protein phosphorylation. Decreased phosphorylation of lenticular fiber proteins reduces their solubility and results in their sorption on the cell membranes, resulting in progressive impairment of the regulatory membrane placement. Light scattering on the folded membrane surfaces in the lenticular fibers is considered to be a main cause of lenticular opacity in cataract.
Deev
A I
AI
Aseĭchev
A V
AV
Vladimirov
Iu A
IuA
D000818:Animals; D002386:Cataract / Q000209:etiology / Q000378:metabolism*; D003459:Crystallins / Q000378:metabolism / Q000528:radiation effects; D006801:Humans; D007908:Lens, Crystalline / Q000378:metabolism* / Q000528:radiation effects; D008027:Light; D051379:Mice; D018384:Oxidative Stress / Q000502:physiology* / Q000528:radiation effects; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012542:Scattering, Radiation
D003459:Crystallins; D017382:Reactive Oxygen Species