Effect of dialyser biocompatibility on recovery from acute renal failure after cadaver renal transplantation.
BACKGROUND
It has been reported that patients with acute renal failure (ARF) requiring haemodialysis show an improved recovery of renal function when the dialysis treatment is performed using a biocompatible membrane rather than a bioincompatible membrane. However, most recent published human trials have not been able to confirm these findings.


METHODS
Over a 2-year period, we prospectively studied 53 patients with ARF after cadaver renal transplantation who required haemodialysis and randomized them into two treatment groups. One group underwent dialysis with a cuprophane membrane and the other group underwent haemodialysis with a more biocompatible membrane, polysulfone. All patients received an immunosuppressive regimen which included azathioprine, prednisone and cyclosporine.


RESULTS
There was no difference by patient characteristics or immunosuppressive regimen before acute tubular necrosis (ATN) recovery. In both groups the number of haemodialysis sessions required prior to the recovery of renal function (6.57+/-2.79 vs 6.05+/-2.40), the number of oliguric days (16.25+/-5.14 vs 14.40+/-4.67) and the number of hospital days (33.38+/-12.85 vs 30.10+/-11.00), were not statistically different. There was also no difference in long-term allograft outcome.


CONCLUSIONS
Our data demonstrate that the use of a more biocompatible membrane had no influence on the recovery from acute renal failure after renal transplantation.
Romão
J E
JE
Division of Nephrology, Hospital das Clínicas, University of São Paulo School of Medicine, Brazil.
Abensur
H
H
de Castro
M C
MC
Ianhez
L E
LE
Massola
V C
VC
Sabbaga
E
E
D058186:Acute Kidney Injury / Q000628:therapy*; D000328:Adult; D000368:Aged; D001672:Biocompatible Materials; D002102:Cadaver; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D011446:Prospective Studies; D006435:Renal Dialysis
D001672:Biocompatible Materials; D008567:Membranes, Artificial