title: New cycloalkylpyrazoles as potential cyclooxygenase inhibitors.
abstract: In this study some cycloalkyl-3-(N-substituted carbamoyl)-1-phenylpyrazoles have been synthesized in order to screen their capability to inhibit human cyclooxygenase. The synthetic pathway is based on the well known property of nitrilimines to undergo 1,3-dipolar cycloaddition reactions. The structures of all the synthesized compounds have been elucidated by means of both analytical and spectroscopic methods.
authors: M C
authors: MC
authors: Cardia
authors: L
authors: L
authors: Corda
authors: A M
authors: AM
authors: Fadda
authors: A M
authors: AM
authors: Maccioni
authors: E
authors: E
authors: Maccioni
authors: A
authors: A
authors: Plumitallo
mesh_terms: D016861:Cyclooxygenase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D016861:Cyclooxygenase Inhibitors; D011720:Pyrazoles