Proteolytic control of growth factor availability.
Most growth factors are released from cells in a form that does not permit immediate interaction with their high affinity receptors. An important mechanism for presentation of these released latent growth factors is activation by the plasminogen activator-plasmin system. The involvement of this system in the biology of Transforming Growth Factor-beta (TGF-beta) is reviewed.
Rifkin
D B
DB
Department of Cell Biology, New York University Medical Center, NY 10016, USA.
Mazzieri
R
R
Munger
J S
JS
Noguera
I
I
Sung
J
J
D000818:Animals; D002352:Carrier Proteins / Q000502:physiology; D005341:Fibrinolysin / Q000502:physiology*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D053779:Latent TGF-beta Binding Proteins; D010960:Plasminogen Activators / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000378:metabolism*
D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; D053779:Latent TGF-beta Binding Proteins; D016212:Transforming Growth Factor beta; D010960:Plasminogen Activators; D005341:Fibrinolysin