title: Endoscopic ultrasound guided fine needle aspiration biopsy: a large single centre experience.
abstract: BACKGROUND
  Endoscopic ultrasound guided fine needle aspiration biopsy (EUS-FNA) is a recent innovation in the evaluation of gastrointestinal and pulmonary malignancies.
  
  
  OBJECTIVE
  To review the experience with EUS-FNA of a large single centre.
  
  
  METHODS
  333 consecutive patients underwent EUS-FNA. Follow up data were available on 327 lesions in 317 patients, including 160 lymph nodes, 144 pancreatic lesions, 15 extraintestinal masses, and eight intramural tumours.
  
  
  RESULTS
  A primary diagnosis of malignancy was obtained by EUS-FNA in 62% of patients with clinically suspicious lesions. The overall accuracy of EUS-FNA for the diagnosis of malignancy was 86%, with sensitivity of 84% and specificity of 96%. With respect to lesion types, the sensitivity, specificity, and accuracy were 85%, 100%, and 89% for lymph nodes; 82%, 100%, and 85% for pancreatic lesions; 88%, 100%, and 90% for perirectal masses; and 50%, 25%, and 38% for intramural lesions, respectively. Compared with size and sonographic criteria, EUS-FNA in the evaluation of lymph nodes provided superior accuracy and specificity, without compromising sensitivity. Inadequate specimens were obtained from only six patients, including 3/5 with stromal tumors. Only one complication occurred.
  
  
  CONCLUSIONS
  EUS-FNA is safe and can readily obtain tissue specimens adequate for cytopathological diagnoses. Compared with size and sonographic criteria, it is a superior modality for the detection of nodal metastases. While providing accurate diagnosis of pancreatic and perirectal malignancies, results suggest the technique is less useful for intramural lesions.
authors: Digestive Disease Centre, Medical University of South Carolina, Charleston, South Carolina, USA.
authors: D B
authors: DB
authors: Williams
authors: A V
authors: AV
authors: Sahai
authors: L
authors: L
authors: Aabakken
authors: I D
authors: ID
authors: Penman
authors: A
authors: A
authors: van Velse
authors: J
authors: J
authors: Webb
authors: M
authors: M
authors: Wilson
authors: B J
authors: BJ
authors: Hoffman
authors: R H
authors: RH
authors: Hawes
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle / Q000379:methods*; D019160:Endosonography / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D005770:Gastrointestinal Neoplasms / Q000473:pathology; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000473:pathology; D012680:Sensitivity and Specificity; D018084:Ultrasonography, Interventional / Q000379:methods*