Synthesis and hypoglycemic effect of chrysin derivatives.
A series of 18 chrysin derivatives, prepared by alkylation and condensation, were fully characterized by NMR and other techniques and tested in vivo against the diabetes mellitus. Several modified compounds especially those with propyl, butyl, octyl and tolyl groups were found to have hypoglycemic effect on diabetec mice in spite of the fact that chrysin itself had inhibited insulin release by 40-60%. None of the test animals died at the maximum dose 500mg/kg and did not cause any significant change in general feature, water and food consumption, body weight and organ weight when we examined the acute oral toxicity of those compounds having significant hypoglycemic effect.
Shin
J S
JS
College of Pharmacy, Seoul National University, Korea.
Kim
K S
KS
Kim
M B
MB
Jeong
J H
JH
Kim
B K
BK
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000633:toxicity; D007004:Hypoglycemic Agents / Q000138:chemical synthesis*; D007700:Kinetics; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D005419:Flavonoids; D007004:Hypoglycemic Agents; C043561:chrysin