Early diagnosis of dementia: which tests are indicated? What are their costs?
Dementia is reversible in a minority of patients, and these should be diagnosed but without subjecting the majority with irreversible disease to an excessive set of investigations. Should a battery of ancillary investigations be performed routinely in dementia? Or can these tests be carried out as clinically indicated? Three arguments are important to answer this question. (a) Reversible dementia is rare: about 1% of cases. (b) If the clinical criteria for diagnosing primary degenerative disease are used consistently, the results of investigations can be predicted with sufficient accuracy, except those of blood tests. (c) Treatment of reversible dementia has the best results in its most frequent causes: depression and drug intoxication; however, treatment of medical and surgical causes of dementia may also be effective. Based on these three considerations, we propose the following guideline in the setting of a memory clinic: to perform blood tests in every patient with dementia, but also to perform other tests, such as electroencephalography (EEG) and computed tomography (CT), as clinically indicated.
van Crevel
H
H
Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands.
van Gool
W A
WA
Walstra
G J
GJ
D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis; D001057:Apolipoproteins E / Q000235:genetics; D003363:Cost Control; D003362:Cost-Benefit Analysis; D003704:Dementia / Q000097:blood / Q000139:chemically induced / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D015140:Dementia, Vascular / Q000097:blood / Q000175:diagnosis; D003952:Diagnostic Imaging / Q000191:economics; D003955:Diagnostic Tests, Routine / Q000191:economics; D006801:Humans; D008875:Middle Aged; D009426:Netherlands; D009483:Neuropsychological Tests; D017410:Practice Guidelines as Topic; D011237:Predictive Value of Tests; D015995:Prevalence; D020033:Protein Isoforms / Q000235:genetics; D013702:Temporal Lobe / Q000473:pathology; D016896:Treatment Outcome
D001057:Apolipoproteins E; D020033:Protein Isoforms