title: Systemically administered capsazepine prevents the capsaicin-induced functional desensitization and loss of substance P-like immunoreactivity (SP-LI) in guinea-pig bronchi.
abstract: In this study, we investigated whether the systemically administered capsazepine can prevent the capsaicin-induced desensitization ex vivo in guinea-pig bronchi. Pretreatment with capsaicin (2.5, 5 and 10 mg/kg, s.c.) induced the functional desensitization and the loss of substance P-like immunoreactivity (SP-LI) with a similar potency (ED50: 3.31 +/- 0.57 and 4.81 +/- 0.89 mg/kg, respectively) in isolated guinea-pig bronchi. Capsazepine (30 mg/kg, s.c.) co-administered with capsaicin (5 mg/kg, s.c.) prevented the capsaicin (5 mg/kg, s.c.)-induced functional desensitization and loss of SP-LI. These results suggest that capsazepine can antagonize systemically the desensitizing action of capsaicin at the level of receptor, preventing the loss of SP-LI and the establishment of functional desensitization in guinea-pig bronchi.
authors: Korea Research Institute of Chemical Technology, Taejon.
authors: Y S
authors: YS
authors: Jung
authors: T S
authors: TS
authors: Cho
authors: C H
authors: CH
authors: Moon
authors: B
authors: B
authors: Lee
authors: S M
authors: SM
authors: Lee
authors: H S
authors: HS
authors: Shin
mesh_terms: D000818:Animals; D001980:Bronchi / Q000737:chemistry / Q000187:drug effects*; D002211:Capsaicin / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D008297:Male; D013373:Substance P / Q000032:analysis* / Q000276:immunology
chemical_list: D013373:Substance P; C071423:capsazepine; D002211:Capsaicin