title: Complete mutism after midbrain periaqueductal gray lesion.
abstract: Several neurophysiological studies have highlighted the role of the midbrain periaqueductal gray matter (PAG) in the initiation of vocalization in various animal species, from frogs to primates. With regard to humans, only two cases of complete mutism following a lesion to the PAG have been reported so far. This article describes a new case of a patient (GM) who, following an ischemic lesion to the periaqueductal gray region of the midbrain, presented with complete and irreversible mutism, though her language comprehension functions and her non-verbal expression capacity were preserved. This clinical case provides evidence that in humans the PAG also acts as a link between different vocalization-eliciting external and internal stimuli (which reach the PAG from sensory and emotional structures) and the vocal-motor coordinating mechanisms in the lower brain stem.
authors: Service de Revalidation Neurologique, CHU Brugmann, Université Libre de Bruxelles, Brussels, Belgium.
authors: A
authors: A
authors: Esposito
authors: G
authors: G
authors: Demeurisse
authors: B
authors: B
authors: Alberti
authors: F
authors: F
authors: Fabbro
mesh_terms: D000368:Aged; D001933:Brain Stem / Q000502:physiology; D002561:Cerebrovascular Disorders / Q000150:complications* / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009155:Mutism / Q000209:etiology*; D010487:Periaqueductal Gray / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D014705:Verbal Behavior