title: [Therapy of patients with primary open-angle glaucoma with proxofelin, a combined form of proxodolol].
abstract: Effects of an original Russian combined preparation proxofelin consisting of 1% proxodolol and 0.25% clofelin solutions on intraocular pressure, ocular hemodynamics, pupil size, depth of the anterior chamber, ocular functions, arterial pressure, and heart rate were studied in 59 patients (80 eyes) with primary open-angle glaucoma. The studies were carried out on day 1 after a single instillation of the drug and after 4-8 weeks of its regular use. Obvious hypotensive effect on intraocular pressure is due to a significant increase of the discharge efficacy coefficient (by 0.06 +/- 0.008) and a 40% suppression of aqueous humor production. Comparison of the efficacies of proxofelin and proxodolol in primary open-angle glaucoma showed the advantages of the combined drug. Unlike cloefelin, the drug was well tolerated.
authors: V N
authors: VN
authors: Ermakova
authors: S L
authors: SL
authors: Malinina
authors: M Zh
authors: MZh
authors: Abdulkadyrova
authors: O M
authors: OM
authors: Filippova
authors: G D
authors: GD
authors: Maliuta
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003000:Clonidine / Q000008:administration & dosage / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D010069:Oxadiazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000317:Adrenergic alpha-Antagonists; D000959:Antihypertensive Agents; D004338:Drug Combinations; D009883:Ophthalmic Solutions; D010069:Oxadiazoles; C088649:proxodolol; D003000:Clonidine