Dermatofibrosarcoma protuberans harboring t(9;22)(q32;q12.2).
More than 20 cases of dermatofibrosarcoma protuberans (DFSP) exhibiting chromosomal abnormalities have been reported. Approximately three fourths of these tumors have harbored supernumerary ring chromosomes, which have been suggested to be specific for this tumor. However, a small number of DFSPs with translocations such as t(2;17), t(X;7), and t(17;22) have recently been reported. We report a DFSP arising in a 23-year-old woman which unexpectedly exhibited the balanced translocation, t(9;22)(q32;q12.2) as the only anomaly with G-band technique. Dual-color fluorescence in situ hybridization (FISH) confirmed these cytogenetic findings. Similar to that previously reported for DFSPs with translocations, the present tumor also lacked ring chromosomes.
Sonobe
H
H
Department of Pathology, Kochi Medical School, Japan.
Furihata
M
M
Iwata
J
J
Ohtsuki
Y
Y
Chikazawa
M
M
Taguchi
T
T
Shimizu
K
K
D000328:Adult; D002892:Chromosomes, Human, Pair 22; D002899:Chromosomes, Human, Pair 9; D018223:Dermatofibrosarcoma / Q000235:genetics*; D005260:Female; D006801:Humans; D012878:Skin Neoplasms / Q000235:genetics*; D014178:Translocation, Genetic