Development of inflammatory hypersensitivity and augmentation of sodium channels in rat dorsal root ganglia.
The development of thermal allodynia in relationship to sodium channel augmentation in dorsal root ganglia (DRGs) was studied in albino rats. Paw withdrawal latencies were measured hourly following complete Freund's adjuvant (CFA) injections. Sodium channels were demonstrated with immunocytochemistry. Sustained minimum latencies were attained between 10 and 12 h post-injection. Sodium channel labeling began to increase at 23 h post-injection and reached maximum levels by 24 h. Thermal hypersensitivity is thus established 12 h before sodium channel augmentation can be demonstrated.
Gould
H J
HJ
Department of Neurology, Louisiana State University Medical Center, 1542 Tulane Avenue, New Orleans, LA 70112, USA. hgould@lsumc.edu
Gould
T N
TN
Paul
D
D
England
J D
JD
Liu
Z P
ZP
Reeb
S C
SC
Levinson
S R
SR
D000818:Animals; D018450:Disease Progression; D005727:Ganglia, Spinal / Q000503:physiopathology*; D006358:Hot Temperature; D006967:Hypersensitivity / Q000503:physiopathology*; D007150:Immunohistochemistry; D009443:Neuritis / Q000503:physiopathology*; D017288:Pain Threshold; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time / Q000502:physiology; D015222:Sodium Channels / Q000502:physiology*
D015222:Sodium Channels