SPA1, a WD-repeat protein specific to phytochrome A signal transduction.
The five members of the phytochrome photoreceptor family of Arabidopsis thaliana control morphogenesis differentially in response to light. Genetic analysis has identified a signaling pathway that is specifically activated by phytochrome A. A component in this pathway, SPA1 (for "suppressor of phyA-105"), functions in repression of photomorphogenesis and is required for normal photosensory specificity of phytochrome A. Molecular cloning of the SPA1 gene indicates that SPA1 is a WD (tryptophan-aspartic acid)-repeat protein that also shares sequence similarity with protein kinases. SPA1 can localize to the nucleus, suggesting a possible function in phytochrome A-specific regulation of gene expression.
Hoecker
U
U
Department of Plant and Microbial Biology, University of California Berkeley, Berkeley, CA 94720, USA.
Tepperman
J M
JM
Quail
P H
PH
D000595:Amino Acid Sequence; D017360:Arabidopsis / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D029681:Arabidopsis Proteins; D018797:Cell Cycle Proteins / Q000737:chemistry* / Q000502:physiology*; D002467:Cell Nucleus / Q000378:metabolism; D003001:Cloning, Molecular; D003624:Darkness; D018506:Gene Expression Regulation, Plant; D008027:Light; D008969:Molecular Sequence Data; D009024:Morphogenesis; D009154:Mutation; D019913:Nuclear Localization Signals; D010834:Phytochrome / Q000378:metabolism*; D051942:Phytochrome A; D010940:Plant Proteins / Q000737:chemistry* / Q000235:genetics / Q000502:physiology; D011494:Protein Kinases / Q000737:chemistry; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D020449:Repetitive Sequences, Amino Acid; D012097:Repressor Proteins / Q000737:chemistry; D016415:Sequence Alignment; D015398:Signal Transduction
D029681:Arabidopsis Proteins; D018797:Cell Cycle Proteins; D019913:Nuclear Localization Signals; C497973:PHYA protein, Arabidopsis; D051942:Phytochrome A; D010940:Plant Proteins; D012333:RNA, Messenger; D012097:Repressor Proteins; C118571:SPA1 protein, Arabidopsis; D010834:Phytochrome; D011494:Protein Kinases