Synergistic effects of anthraquinones on the purgative activity of rhein anthrone in mice.
This study was performed to determine whether intracaecally administered rhein anthrone and anthraquinones such as aloe-emodin, chrysophanol, emodin or rhein synergistically enhance the purgative action as has been observed for rhein anthrone and aloe-emodin anthrone. These anthraquinones were less potent than rhein anthrone. An equimolar mixture of aloe-emodin and rhein anthrone had synergistic potentiating effects because the ED50 value (50% purgative dose) of the combination was smaller than that calculated additively from the ED50 values of aloe-emodin and rhein anthrone. An equimolar mixture of other anthraquinones and rhein anthrone tended to potentiate the purgative action. These results confirmed that rhein anthrone and aloe-emodin synergistically exert a purgative action as has been observed for rhein anthrone and aloe-emodin anthrone.
Yagi
T
T
Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Hyogo, Japan.
Yamauchi
K
K
D000818:Animals; D000873:Anthracenes / Q000494:pharmacology*; D000880:Anthraquinones / Q000494:pharmacology*; D002400:Cathartics / Q000494:pharmacology*; D004357:Drug Synergism; D004642:Emodin / Q000494:pharmacology*; D005260:Female; D051379:Mice; D009934:Organization and Administration; D000095322:Anthrones
D000873:Anthracenes; D000880:Anthraquinones; D002400:Cathartics; D004642:Emodin; C518327:aloe emodin; C004522:anthrone; D000095322:Anthrones; C027113:chrysophanic acid