title: Mouse-to-rat testicle transplantation.
abstract: This report details mouse-to-rat testicular transplantation with immediate revascularization. Donor preparation involved grafting a long segment of aorta and inferior vena cava (IVC) containing the testicular artery and vein. The graft aorta and IVC were anastomosed to the rat aorta and IVC, respectively. Vasovasostomy was completed and the scrotal epithelia were anastomosed to draw the graft toward the host scrotal sac. Twenty-nine of 53 transplants were determined to be viable. Histologically, 6- to 18-hr-old grafts displayed moderate to minimal polymorphonuclear neutrophil (PMN) infiltrates. Ischemia set in somewhere between 18-24 hr postoperatively. Beyond 24 hr the grafts displayed progressive infiltration of PMN and perivascular and intertubular lymphocytes, disorganization of the germinal epithelium, and cessation of spermatogenesis.
authors: The San Diego Microsurgical Institute, California 92103, USA.
authors: S
authors: S
authors: Lee
authors: Y
authors: Y
authors: Wang
authors: S
authors: S
authors: Kim
authors: C
authors: C
authors: Cho
authors: T
authors: T
authors: Tarin
authors: B
authors: B
authors: Sileshi
authors: J H
authors: JH
authors: Yoon
authors: G
authors: G
authors: Mazzoni
authors: T
authors: T
authors: Youngkin
authors: P
authors: P
authors: Wolf
authors: R F
authors: RF
authors: Gittes
mesh_terms: D000818:Animals; D004848:Epithelium / Q000601:surgery; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008866:Microsurgery / Q000379:methods; D011184:Postoperative Period; D051381:Rats; D017207:Rats, Sprague-Dawley; D012611:Scrotum / Q000601:surgery; D013536:Suture Techniques; D013737:Testis / Q000473:pathology / Q000637:transplantation*; D013997:Time Factors; D014183:Transplantation, Heterologous / Q000379:methods* / Q000473:pathology; D013521:Urologic Surgical Procedures, Male / Q000379:methods*