Efficacy of parenterally or intramammarily administered tilmicosin or ceftiofur against Staphylococcus aureus mastitis during lactation.
Two antibiotic preparations, tilmicosin and ceftiofur, were tested intramammarily and parenterally against Staphylococcus aureus mastitis in lactating cows. Neither product was effective as a lactating cow treatment at the doses and durations of treatment tested. Injection or infusion of tilmicosin and infusion of ceftiofur resulted in reductions of bacteria present in milk; however, only one quarter treated with infusion of tilmicosin was cured, and no cures were observed for the other treatments. Somatic cell counts were transiently reduced by infusion of ceftiofur and by infusion and injection of tilmicosin; however, they returned to pretreatment values by 28 d posttreatment.
Owens
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Mastitis Research Laboratory, Louisiana Agricultural Experiment Station, Louisiana State University Agricultural Center, Homer 71040, USA.
Nickerson
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SC
Ray
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CH
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002417:Cattle; D002511:Cephalosporins / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D007262:Infusions, Intravenous; D007279:Injections, Subcutaneous; D007774:Lactation; D018942:Macrolides; D008321:Mammary Glands, Animal / Q000187:drug effects*; D008414:Mastitis, Bovine / Q000188:drug therapy*; D008892:Milk / Q000382:microbiology; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000662:veterinary*; D013211:Staphylococcus aureus / Q000302:isolation & purification; D016896:Treatment Outcome; D015645:Tylosin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D018942:Macrolides; C053503:ceftiofur; C052319:tilmicosin; D015645:Tylosin