title: Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis.
abstract: We show that fibroblast growth factor 2 (FGF2) and FGF receptors are transiently expressed by cells of the pseudostratified ventricular epithelium (PVE) during early neurogenesis. A single microinjection of FGF2 into cerebral ventricles of rat embryos at E15.5 increased the volume and total number of neurons in the adult cerebral cortex by 18% and 87%, respectively. Microinjection of FGF2 by the end of neurogenesis, at E20.5, selectively increased the number of glia. Mice lacking the FGF2 gene had fewer cortical neurons and glia at maturity. BrdU studies in FGF2-microinjected and FGF2-null animals suggested that FGF2 increases the proportion of dividing cells in the PVE without affecting the cell-cycle length. Thus, FGF2 increases the number of rounds of division of cortical progenitors.
authors: Child Study Center, Yale University, New Haven, Connecticut 06520, USA.
authors: F M
authors: FM
authors: Vaccarino
authors: M L
authors: ML
authors: Schwartz
authors: R
authors: R
authors: Raballo
authors: J
authors: J
authors: Nilsen
authors: J
authors: J
authors: Rhee
authors: M
authors: M
authors: Zhou
authors: T
authors: T
authors: Doetschman
authors: J D
authors: JD
authors: Coffin
authors: J J
authors: JJ
authors: Wyland
authors: Y T
authors: YT
authors: Hung
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000196:embryology*; D004622:Embryo, Mammalian / Q000033:anatomy & histology / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D005314:Embryonic and Fetal Development / Q000502:physiology; D016222:Fibroblast Growth Factor 2 / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology; D005346:Fibroblast Growth Factors / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout / Q000235:genetics; D008845:Microinjections; D051381:Rats / Q000196:embryology; D013234:Stem Cells / Q000502:physiology
chemical_list: D016222:Fibroblast Growth Factor 2; D005346:Fibroblast Growth Factors