title: Fragile X premutation is a significant risk factor for premature ovarian failure: the International Collaborative POF in Fragile X study--preliminary data.
abstract: The preliminary results of an international collaborative study examining premature menopause in fragile X carriers are presented. A total of 760 women from fragile X families was surveyed about their fragile X carrier status and their menstrual and reproductive histories. Among the subjects, 395 carried a premutation, 128 carried a full mutation, and 237 were noncarriers. Sixty-three (16%) of the premutation carriers had experienced menopause prior to the age of 40 compared with none of the full mutation carriers and one (0.4%) of the controls. Based on these preliminary data, there is a significant association between fragile X premutation carrier status and premature menopause.
authors: dallingh@nygh.on.ca
authors: D J
authors: DJ
authors: Allingham-Hawkins
authors: R
authors: R
authors: Babul-Hirji
authors: D
authors: D
authors: Chitayat
authors: J J
authors: JJ
authors: Holden
authors: K T
authors: KT
authors: Yang
authors: C
authors: C
authors: Lee
authors: R
authors: R
authors: Hudson
authors: H
authors: H
authors: Gorwill
authors: S L
authors: SL
authors: Nolin
authors: A
authors: A
authors: Glicksman
authors: E C
authors: EC
authors: Jenkins
authors: W T
authors: WT
authors: Brown
authors: P N
authors: PN
authors: Howard-Peebles
authors: C
authors: C
authors: Becchi
authors: E
authors: E
authors: Cummings
authors: L
authors: L
authors: Fallon
authors: S
authors: S
authors: Seitz
authors: S H
authors: SH
authors: Black
authors: A M
authors: AM
authors: Vianna-Morgante
authors: S S
authors: SS
authors: Costa
authors: P A
authors: PA
authors: Otto
authors: R C
authors: RC
authors: Mingroni-Netto
authors: A
authors: A
authors: Murray
authors: J
authors: J
authors: Webb
authors: F
authors: F
authors: Vieri
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005600:Fragile X Syndrome; D006579:Heterozygote; D006801:Humans; D007391:International Cooperation; D008593:Menopause; D008597:Menstrual Cycle; D008875:Middle Aged; D016649:Primary Ovarian Insufficiency; D012307:Risk Factors