Galaninergic signalling and adenylate cyclase.
Galanin is a hyperpolarizing, inhibitory neurotransmitter; its recognition by seven transmembrane spanning G-protein-coupled receptors leads to a change in accumulation of cAMP (3'5'-cyclic AMP). Different subtypes of galanin receptor and G-proteins could be manifested in the mode of inhibitory action of galanin receptor on the production of cAMP by adenylate cyclase. Galanin analogues, acting at the adenylate cyclase level as subtype-specific galanin antagonists, can selectively block the inhibitory effect of endogenous galanin and thereby have potential as therapeutic agents for several endocrine, neuroendocrine and neuronal disorders. In this review, the latest results in the field of interplay between galanin-initiated signal transduction and the cAMP pathway are summarized.
Karelson
E
E
Department of Biochemistry, Tartu University, Estonia.
Langel
U
U
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000502:physiology; D019004:Galanin / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D044088:Receptors, Galanin; D018013:Receptors, Neuropeptide / Q000037:antagonists & inhibitors / Q000502:physiology; D015398:Signal Transduction
D007328:Insulin; D044088:Receptors, Galanin; D018013:Receptors, Neuropeptide; D019004:Galanin; D000242:Cyclic AMP; D019204:GTP-Binding Proteins; D000262:Adenylyl Cyclases