Is gliadin mispresented to the immune system in coeliac disease? A hypothesis.
The primary pathogenic trigger in coeliac disease (CD) is still unknown. We present the hypothesis that in CD the enterocytes could metabolize gliadin through an immunogenic pathway instead of a tolerogenic one. The result of this abnormal presentation of gliadin to the immune system would be the activation of lamina propria T cells, followed by the onset of enteropathy.
Biagi
F
F
Gastroentrology Unit (GKT), Rayne Institute, St Thomas' Hospital, London, UK.
Zimmer
K P
KP
Thomas
P D
PD
Ellis
H J
HJ
Ciclitira
P J
PJ
D000938:Antigen-Presenting Cells / Q000276:immunology*; D015703:Antigens, CD / Q000276:immunology; D002446:Celiac Disease / Q000276:immunology*; D005805:Genes, MHC Class I / Q000276:immunology; D005903:Gliadin / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007107:Immune System / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D011503:Transglutaminases / Q000276:immunology
D015703:Antigens, CD; D005903:Gliadin; D011503:Transglutaminases