[Loss of heterozygosity and microsatellite instability in laryngeal carcinoma near p16 gene].
OBJECTIVE
To search for the minimal overlap region of tumor suppressor gene in laryngeal carcinoma and discuss the correlation of p16 gene with laryngeal carcinogenesis.


METHODS
Five microsatellite polymorphism markers near p16 gene were selected to detect loss of heterozygosity (LOH) and microsatellite instability (MI) in 60 cases of laryngeal squamous cell carcinoma.


RESULTS
The frequencies of LOH in 5 markers were less than 23.1%, while the frequencies of MI in 2 markers were higher, with the highest frequency (46.1%) in D9S1752.


CONCLUSIONS
The results suggest that the deletion of p16 gene does not play an important role in the laryngeal carcinogenesis and there may exist a gene around D9S1752 participating in the development of laryngeal carcinoma, which correlates with the mutation of repair gene.
Wu
D
D
Department of Medical Genetics, China Medical University, Shenyang, 110001, P. R. China.
Fu
W
W
Jiang
L
L
Zhang
X
X
Li
F
F
Guo
X
X
Sun
K
K
D017353:Gene Deletion; D019942:Genes, p16; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics*; D019656:Loss of Heterozygosity; D018895:Microsatellite Repeats