title: Hyperacute stroke: simultaneous measurement of relative cerebral blood volume, relative cerebral blood flow, and mean tissue transit time.
abstract: OBJECTIVE
  To investigate additional information provided by maps of relative cerebral blood flow in functional magnetic resonance (MR) imaging of human hyperacute cerebral ischemic stroke.
  
  
  METHODS
  Diffusion-weighted and hemodynamic MR imaging were performed in 23 patients less than 12 hours after the onset of symptoms. Maps of relative cerebral blood flow and tracer mean tissue transit time were computed, as were maps of apparent diffusion and relative cerebral blood volume. Acute lesion volumes on the maps were compared with follow-up imaging findings.
  
  
  RESULTS
  In 15 of 23 subjects (65%), blood flow maps revealed hemodynamic abnormalities not visible on blood volume maps. A mismatch between initial blood flow and diffusion findings predicted growth of infarct more often (12 of 15 subjects with infarcts that grew) than did a mismatch between initial blood volume and diffusion findings (eight of 15). However, lesion volumes on blood volume and diffusion maps correlated better with eventual infarct volumes (r > 0.90) than did those on blood flow and tracer mean transit time maps (r approximately 0.6), likely as a result of threshold effects. In eight patients, blood volume was elevated around the diffusion abnormality, suggesting a compensatory hemodynamic response.
  
  
  CONCLUSIONS
  MR imaging can delineate areas of altered blood flow, blood volume, and water mobility in hyperacute human stroke. Predictive models of tissue outcome may benefit by including computation of both relative cerebral blood flow and blood volume.
authors: Department of Radiology, Massachusetts General Hospital, MGH-NMR Center, Charlestown 02129, USA.
authors: A G
authors: AG
authors: Sorensen
authors: W A
authors: WA
authors: Copen
authors: L
authors: L
authors: Ostergaard
authors: F S
authors: FS
authors: Buonanno
authors: R G
authors: RG
authors: Gonzalez
authors: G
authors: G
authors: Rordorf
authors: B R
authors: BR
authors: Rosen
authors: L H
authors: LH
authors: Schwamm
authors: R M
authors: RM
authors: Weisskoff
authors: W J
authors: WJ
authors: Koroshetz
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D001810:Blood Volume; D001921:Brain / Q000473:pathology*; D002545:Brain Ischemia / Q000175:diagnosis* / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D017352:Echo-Planar Imaging; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D013997:Time Factors