A single dose of milrinone facilitates separation from cardiopulmonary bypass in patients with pre-existing left ventricular dysfunction.
Milrinone is used during cardiac surgery to facilitate separation from cardiopulmonary bypass (CPB) and/or to treat myocardial dysfunction in the post-bypass period. We have demonstrated, in patients with preoperative depression of systolic function undergoing aorto-coronary artery bypass surgery, sustained improvement in cardiac function after a single loading dose of milrinone 50 micrograms kg-1, administered at the end of bypass, thus significantly decreasing the need for beta-agonist therapy.
Lobato
E B
EB
Department of Anesthesiology, University of Florida College of Medicine, Gainesville, USA.
Florete
O
O
Bingham
H L
HL
D000328:Adult; D002315:Cardiopulmonary Bypass; D002316:Cardiotonic Agents / Q000008:administration & dosage*; D001026:Coronary Artery Bypass; D004334:Drug Administration Schedule; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007430:Intraoperative Care / Q000379:methods*; D020105:Milrinone / Q000008:administration & dosage*; D018487:Ventricular Dysfunction, Left / Q000188:drug therapy*
D002316:Cardiotonic Agents; D020105:Milrinone