Cytotoxic effects of different concentrations of neutral and alkaline EDTA solutions used as root canal irrigants.
The cytotoxic effects of neutral and alkaline EDTA solutions were evaluated and compared with those of sodium hypochlorite solution using an established cell line: L929. Cytotoxicity was assessed by a quantitative technique at five observation periods (1, 3, 6, 12, and 24 h). All tested agents showed moderate to severe cytotoxicity in the present experimental model in a concentration-dependent manner.
Koulaouzidou
E A
EA
Department of Dental Pathology and Therapeutics, Dental School, Aristotle University, Thessaloniki, Greece.
Margelos
J
J
Beltes
P
P
Kortsaris
A H
AH
D000704:Analysis of Variance; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D004492:Edetic Acid / Q000633:toxicity*; D006863:Hydrogen-Ion Concentration; D007739:L Cells / Q000187:drug effects; D051379:Mice; D012388:Root Canal Irrigants / Q000633:toxicity*; D012973:Sodium Hypochlorite / Q000633:toxicity
D012388:Root Canal Irrigants; D004492:Edetic Acid; D012973:Sodium Hypochlorite