The pathology of pituitary tumors.
The pathologist plays an important role in the distinction of pituitary adenomas from other tumors and tumor-like lesions of the sellar region, and in the accurate morphologic characterization of pitutiary adenomas. A clinicopathologic classification of pituitary adenomas is based on cell differentiation correlated with clinical evidence of hormone secretion; this classification emphasizes clinically relevant features that can offer guidance for patient management. The application of a rational approach to the immunohistochemical analysis of these lesions can be used to evaluate pathogenetic and prognostic markers and to predict responses to specific therapeutic modalities.
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Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada.
D000236:Adenoma / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology; D000324:Adrenocorticotropic Hormone / Q000096:biosynthesis; D000818:Animals; D019382:Human Growth Hormone / Q000096:biosynthesis; D006801:Humans; D010911:Pituitary Neoplasms / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology*; D011388:Prolactin / Q000096:biosynthesis; D013972:Thyrotropin / Q000096:biosynthesis
D019382:Human Growth Hormone; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D013972:Thyrotropin