Effect of the formulation on the in-vitro release of propranolol from gellan beads.
Gellan gum beads of propranolol hydrochloride, a hydrophilic model drug, were prepared by solubilising the drug in a dispersion of gellan gum and then dropping the dispersion into calcium chloride solution. The droplets formed gelled beads instantaneously by ionotropic gelation. Major formulation and process variables which might influence the preparation of the beads and the drug release from gellan gum beads were studied. Very high entrapment efficiencies were obtained (92%) after modifying the pH of both the gellan gum dispersion and the calcium chloride solution. The beads could be stored for 3 weeks in a wet or dried state without modification of the drug release. Oven-dried beads released the drug somewhat more slowly than the wet or freeze-dried beads. The drug release from oven-dried beads was slightly affected by the pH of the dissolution medium. Gellan gum could be a useful carrier for the encapsulation of fragile drugs and provides new opportunities in the field of bioencapsulation.
Kedzierewicz
F
F
Laboratoire de Pharmacie Galénique, Faculté de Pharmacie, Université Henri Poincaré, Nancy, France. kedziere@pharma.u-nancy.fr
Lombry
C
C
Rios
R
R
Hoffman
M
M
Maincent
P
P
D002122:Calcium Chloride / Q000737:chemistry*; D002214:Capsules; D002626:Chemistry, Pharmaceutical; D016503:Drug Delivery Systems; D004355:Drug Stability; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D007478:Iontophoresis; D011135:Polysaccharides, Bacterial / Q000737:chemistry*; D011433:Propranolol / Q000493:pharmacokinetics*; D012995:Solubility; D012997:Solvents / Q000737:chemistry
D002214:Capsules; D011135:Polysaccharides, Bacterial; D012997:Solvents; C048288:gellan gum; D011433:Propranolol; D002122:Calcium Chloride