Anti-inflammatory activity of the crude extract from the fruits of Pterodon emarginatus Vog.
The vegetal species Pterodon emarginatus Vog. (Leguminosae/Papilonaceae), popularly known in Brazil as 'sucupira branca', is widely used by domestic medicine as an anti-inflammatory. From these observations, the hexanic crude extract (HCE) of the fruits was obtained and submitted for assessment of its anti-inflammatory activity. For this purpose, the following tests were used: (1) Determination of ED50 and LD50; (2) Paw edema induced by carrageenin, dextran, histamine and nystatin; (3) Peritonitis caused by carrageenin and (4) Granuloma test. The ED50 (oral) in the edema induced by carrageenin was 500 mg/kg, and LD50 (oral) was 4.02 g/kg. In the edema caused by nystatin, there was a significant inhibition by 45% (P < 0.05 student's t-test) at the 6th hour following the treatment. In the granuloma test performed in animals treated with HCE, there was an inhibition of the granulomatous tissue formation by 22%. The migration of neutrophils towards the peritoneal cavity was inhibited in HCE treated animals by 43% (P < 0.05). However, in the edema caused by dextran and histamine, there was no significant response in HCE treated animals.
Carvalho
J C
JC
Laboratório de Fitofármacos, Universidade de Alfenas, Instituto de Farmácia e Nutrição, Minas Gerais, Brazil. jctc@artefinal.com.br
Sertié
J A
JA
Barbosa
M V
MV
Patrício
K C
KC
Caputo
L R
LR
Sarti
S J
SJ
Ferreira
L P
LP
Bastos
J K
JK
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002351:Carrageenan; D003911:Dextrans; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D007887:Fabaceae / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry; D008297:Male; D051379:Mice; D009761:Nystatin; D010936:Plant Extracts / Q000627:therapeutic use; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar
D000893:Anti-Inflammatory Agents; D003911:Dextrans; D010936:Plant Extracts; D009761:Nystatin; D002351:Carrageenan