title: Uptake1, uptake2 and the release of [3H]-noradrenaline in uterine artery of pigs during the oestrous cycle.
abstract: Neuronal uptake (uptake1), extraneuronal uptake (uptake2) and the spontaneous release of 2H-noradrenaline (NA) in uterine artery of swine on days 0, 1-2, 13-14 and 16-18 of the oestrous cycle were studied. It was found that uptake1 was lowest on the day of ovulation (day 0) and then it increased by 37.4% (p < 0.05) and by 93.7% (p < 0.01) on days 1-2 and 13-14, respectively. On days 16-18 of the oestrous cycle uptake1 was insignificantly higher (9.3%) compared to the day 0. Also uptake2 was the lowest on day 0 and next it increased to 180.1% (p < 0.01) on days 1-2. Thereafter this value was still higher compared to day 0 but it had decreasing tendency: 140.3% (p < 0.05) on days 13-14 and 113.8% on days 16-18 of the oestrous cycle. Release of neuronal radioactivity was the lowest on day 0 and then it increased by 40.0-44.2% (p < 0.05), 46.8-49.5% (p < 0.05) and 26.1-28.1% (p > 0.05) on days 1-2, 13-14 and 16-18 of the oestrous cycle, respectively. The release of extraneuronal radioactivity was the highest on day 0 (accepted as 100%) and similarly high (88.6-91.8%) on days 13-14 but markedly lower (28.3-36.0%; p < 0.05) on days 1-2 and 16-18 (43.9-50.1%; p < 0.05) compared to the value on day 0 of the oestrous cycle.
authors: Department of Pharmacology, Faculty of Veterinary Medicine, University of Agriculture and Technology, Olsztyn, Poland.
authors: I
authors: I
authors: Dynarowicz
authors: T
authors: T
authors: Trapkowski
authors: T
authors: T
authors: Pirus
mesh_terms: D000042:Absorption; D000818:Animals; D001158:Arteries / Q000294:innervation / Q000378:metabolism*; D004058:Diffusion; D004971:Estrus / Q000502:physiology*; D005260:Female; D066298:In Vitro Techniques; D009474:Neurons / Q000378:metabolism; D009638:Norepinephrine / Q000493:pharmacokinetics / Q000502:physiology*; D012621:Seasons; D013552:Swine / Q000502:physiology*; D014599:Uterus / Q000098:blood supply*
chemical_list: D009638:Norepinephrine