Interaction between capsaicin and nitrate tolerance in isolated guinea-pig heart.
Capsaicin-induced increases in heart rate and coronary flow were blocked by N(G)-nitro-L-Arg-methyl ester (30 mM) in Langendorff-perfused guinea-pig hearts. Neither heart rate nor coronary flow changed by capsaicin in hearts from animals made tolerant to the hypotensive effect of 30 microg/kg nitroglycerin by the administration of 50 mg/kg nitroglycerin subcutaneously 4 times a day over 3 days. We conclude that the effector function of sensory nerves may deteriorate in nitrate tolerance.
Oroszi
G
G
Department of Pharmacology and Pharmacotherapy, Medical University of Pecs, Hungary. oroszi@apacs.pote.hu
Szilvassy
Z
Z
Nemeth
J
J
Ferdinandy
P
P
Szolcsanyi
J
J
Tosaki
A
A
D000818:Animals; D001120:Arginine / Q000494:pharmacology; D002211:Capsaicin / Q000494:pharmacology*; D003326:Coronary Circulation / Q000187:drug effects; D004347:Drug Interactions; D004361:Drug Tolerance; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009566:Nitrates / Q000494:pharmacology*; D005996:Nitroglycerin / Q000494:pharmacology; D010477:Perfusion; D014665:Vasodilator Agents / Q000494:pharmacology
D004791:Enzyme Inhibitors; D009566:Nitrates; D014665:Vasodilator Agents; D001120:Arginine; D005996:Nitroglycerin; D002211:Capsaicin; D019331:NG-Nitroarginine Methyl Ester