title: Antimicrobial triterpenes from Ilex integra and the mechanism of antifungal action.
abstract: Antimicrobial triterpenes were isolated from the fruits of Ilex integra. Their structures were elucidated by spectral data and identified as rotundic acid (1), ulsolic acid (2) and peduncloside (3). Triterpene 1 showed significantly broad antimicrobial activity against bacteria, yeast and filamentous fungi. The antifungal activity of 1 was reversed by fatty acids. Cellular constituents leaked from Candida albicans cells incubated with triterpene 1. These results suggest that the antimicrobial activity of triterpenes in I. integra is due to a change of membrane permeability arising from membrane lipid alteration.
authors: Faculty of Engineering, Fukuyama University, Japan.
authors: H
authors: H
authors: Haraguchi
authors: S
authors: S
authors: Kataoka
authors: S
authors: S
authors: Okamoto
authors: M
authors: M
authors: Hanafi
authors: K
authors: K
authors: Shibata
mesh_terms: D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D002463:Cell Membrane Permeability / Q000187:drug effects; D005638:Fruit / Q000737:chemistry*; D006801:Humans; D007564:Japan; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology; D014197:Trees; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D010936:Plant Extracts; D014315:Triterpenes