title: A three-dimensional model for arterial tree representation, generated by constrained constructive optimization.
abstract: The computational method of constrained constructive optimization (CCO) has been generalized in two important respects: (1) arterial model trees are now grown within a convex, three-dimensional piece of tissue and (2) terminal flow variability has been incorporated into the model to account for the heterogeneity of blood flow observed in real vascular beds. Although no direct information from topographic anatomy enters the model, computer-generated CCO trees closely resemble corrosion casts of real arterial trees, both on a visual basis and with regard to morphometric parameters. Terminal flow variability was found to induce transitions in the connective structure early in the trees' development. The present generalization of CCO offers--for the first time--the possibility to generate optimized arterial model trees in three dimensions, representing a realistic geometrical substrate for hemodynamic simulation studies. With the implementation of terminal flow variability the model is ready to simulate processes such as the adaptation of arterial diameters to changes in blood flow rate or the formation of different patterns of angiogenesis induced by changing needs of blood supply.
authors: Department of Medical Computer Sciences, University of Vienna, Wien, Austria. rudolf.karch@akh-wien.ac.at
authors: R
authors: R
authors: Karch
authors: F
authors: F
authors: Neumann
authors: M
authors: M
authors: Neumann
authors: W
authors: W
authors: Schreiner
mesh_terms: D000465:Algorithms; D001158:Arteries / Q000033:anatomy & histology / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D001809:Blood Viscosity / Q000502:physiology; D001810:Blood Volume / Q000502:physiology; D003198:Computer Simulation; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008833:Microcirculation / Q000502:physiology; D008954:Models, Biological; D018919:Neovascularization, Physiologic; D012039:Regional Blood Flow / Q000502:physiology; D013269:Stochastic Processes; D014655:Vascular Resistance / Q000502:physiology; D014661:Vasoconstriction / Q000502:physiology; D014664:Vasodilation / Q000502:physiology