[Invertors--intracellular regulators of plasma membrane function].
It has been found that the activation of protein biosynthesis in various cells (hepatocytes, adrenocorticocytes, thyrocytes and myocardiocytes), caused by different factors such as multiple hormones, regeneration, hyperfunction etc., leads to the development of plasmatic membrane hyperpolarization. It has also been shown that during protein biosynthesis activation under genome control there have been synthesized the intracellular regulators of plasmatic membrane state, called invertors. The invertors regulate the activity of membrane enzymes and ion channels, as well as adapt plasma membrane state to the needs of cell. With increasing age, the invertors synthesis alters, and this becomes an important genome-membraneous mechanism of aging. An experimental lifespan prolongation promotes to maintain the synthesis of invertors.
Frol'kis
V V
VV
Institute of Gerontology, Academy of Medical Sciences of Ukraine, Kiev.
D000818:Animals; D002462:Cell Membrane / Q000201:enzymology / Q000235:genetics / Q000502:physiology*; D016922:Cellular Senescence / Q000502:physiology; D004789:Enzyme Activation / Q000502:physiology; D016678:Genome; D007473:Ion Channels / Q000502:physiology; D008564:Membrane Potentials / Q000502:physiology; D010452:Peptide Biosynthesis / Q000502:physiology; D010455:Peptides / Q000502:physiology*; D014176:Protein Biosynthesis
D007473:Ion Channels; D010455:Peptides