[Study of interferon-inducing activity of para-aminobenzoic acid injected subconjunctivally in rabbits].
Para-aminobenzoic acid (PABA) is an early interferon inductor. The present study assesses the interferon-inducing activity of PABA (0.007 and 0.06% solutions) and poludan (Poly A:U) injected subconjunctivally to rabbits. Interferon (If) titer in the conjunctival washings and anterior chamber humor was assessed 4-48 h after injection of If inductors. After the first injection of 0.007% PABA, If titer in the conjunctival washings was constantly increasing and reached the maximum after 48 h (64-128 U/ml). Repeated injection of PABA after 5 days still more stimulated the production of If, with the peak after 24 h (128 U/ml); after 48 h the titer of If was still high. If titers induced by 0.007% PABA and poludan were compatible after both injections in the conjunctiva but not in the anterior chamber humor. With poludan, the maximum If titer (16 U/ml) was observed 6 h postinjection, after which it was no longer detected, while after PABA the maximum If titer (64 U/ml) was observed during the 4th and 12th hours postinjection and then decreased, remaining rather high after 24 h. After 0.06% PABA, If titers were 2-4 times lower in all experiments than after 0.007% PABA. The detected interferon-inducing activity of PABA suggests its therapeutic efficacy in ocular diseases involving disorders in If production.
Akberova
S I
SI
Tazulakhova
E B
EB
Musaev Galbinur
P I
PI
Leont'eva
N A
NA
Stroeva
O G
OG
D010129:4-Aminobenzoic Acid / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D001082:Aqueous Humor / Q000378:metabolism*; D003228:Conjunctiva / Q000378:metabolism*; D004195:Disease Models, Animal; D005500:Follow-Up Studies; D007267:Injections; D007372:Interferons / Q000096:biosynthesis* / Q000187:drug effects; D016849:Keratitis, Herpetic / Q000188:drug therapy* / Q000378:metabolism; D011131:Polyribonucleotides / Q000008:administration & dosage / Q000493:pharmacokinetics; D011817:Rabbits
D000998:Antiviral Agents; D011131:Polyribonucleotides; C044366:poludan; D007372:Interferons; D010129:4-Aminobenzoic Acid