General biological aspects of oncogenesis.
Both genetic and epigenetic events play an important role in oncogenic processes. This review discusses the four hypothesis for the origin of neoplastic transformation (mutational genetic, nonmutational genetic, viral, and epigenetic) in the context of a summary of our current knowledge of the pathobiology of cancer.
D'Amato
G
G
Department of Internal Medicine, Jackson Memorial Hospital, Miami, FL, USA.
Patarca
R
R
D000782:Aneuploidy; D017209:Apoptosis; D002450:Cell Communication; D002455:Cell Division; D002471:Cell Transformation, Neoplastic; D002869:Chromosome Aberrations; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D009154:Mutation; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000209:etiology; D011230:Precancerous Conditions / Q000209:etiology; D014960:X Chromosome