Cellular microbiology: can we learn cell physiology from microorganisms?
Cellular microbiology is a new discipline that is emerging at the interface between cell biology and microbiology. The application of molecular techniques to the study of bacterial pathogenesis has made possible discoveries that are changing the way scientists view the bacterium-host interaction. Today, research on the molecular basis of the pathogenesis of infective diarrheal diseases of necessity transcends established boundaries between cell biology, bacteriology, intestinal pathophysiology, and immunology. The use of microbial pathogens to address questions in cell physiology is just now yielding promising applications and striking results.
Fasano
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Department of Pediatrics and Physiology, and Gastrointestinal Pathophysiology Section, Center for Vaccine Development, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA. afasano@umaryland.edu
D000595:Amino Acid Sequence; D000818:Animals; D001424:Bacterial Infections / Q000382:microbiology / Q000503:physiopathology*; D002118:Calcium / Q000502:physiology; D002477:Cells / Q000382:microbiology*; D006152:Cyclic GMP / Q000502:physiology; D003967:Diarrhea / Q000382:microbiology / Q000503:physiopathology; D005768:Gastrointestinal Hormones; D006801:Humans; D007413:Intestinal Mucosa / Q000382:microbiology* / Q000502:physiology / Q000503:physiopathology*; D008954:Models, Biological; D008969:Molecular Sequence Data; D045265:Natriuretic Peptides; D010455:Peptides / Q000737:chemistry / Q000502:physiology; D016415:Sequence Alignment; D015398:Signal Transduction
D005768:Gastrointestinal Hormones; D045265:Natriuretic Peptides; D010455:Peptides; C072685:guanylin; D006152:Cyclic GMP; D002118:Calcium