Synthesis of novel 4'-C-methyl-pyrimidine nucleosides and their biological activities.
Two novel 4'-C-methylnucleosides, 4'-methylBVDU 9 and 4'-methylBVaraU 10, were synthesized. The former was derived from 3',5'-di-O-acetyl-2'-deoxy-4'-C-methyluridine 12, and the latter was produced via glycosylation between 4-C-methyl-D-ribose derivative 11 and a silylated bromovinyl uracil. 4'-MethylBVDU 9 exhibited particularly potent anti-varicella-zoster virus (VZV) activity in vitro.
Kitano
K
K
Biochemicals Division, Yamasa Corporation, Choshi, Chiba, Japan.
Machida
H
H
Miura
S
S
Ohrui
H
H
D000998:Antiviral Agents / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007700:Kinetics; D008956:Models, Chemical; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000378:metabolism* / Q000494:pharmacology
D000998:Antiviral Agents; D011741:Pyrimidine Nucleosides