The efficacy of short-term danazol prophylaxis in hereditary angioedema patients undergoing maxillofacial and dental procedures.
OBJECTIVE
This study evaluated the efficacy of short-term danazol prophylaxis in hereditary angioedema patients undergoing maxillofacial or dental procedures.


METHODS
Twelve patients with a history of edema after dental procedures were administered danazol (600 mg/d) 4 days preoperatively and 4 days postoperatively. The serum levels of complement components were determined preoperatively and postoperatively as well as at 6, 12 and 24 hours in six patients.


RESULTS
None of the 12 patients developed angioneurotic edema. The serum levels of the complement components were decreased immediately after surgery and returned to normal within 24 hours.


CONCLUSIONS
The short-term prophylactic use of danazol in patients with hereditary angioedema undergoing oral surgery is an effective preventive measure.
Farkas
H
H
Department of Oto-Rhino-Laryngology, National Institute of Immunology and Haematology, Budapest, Hungary.
Gyeney
L
L
Gidófalvy
E
E
Füst
G
G
Varga
L
L
D000328:Adult; D000799:Angioedema / Q000097:blood / Q000517:prevention & control*; D003613:Danazol / Q000008:administration & dosage*; D017742:Dental Care for Chronically Ill / Q000379:methods*; D004965:Estrogen Antagonists / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011300:Preoperative Care; D013515:Surgery, Oral; D013997:Time Factors
D004965:Estrogen Antagonists; D003613:Danazol