A case of chronic neutrophilic leukemia with deletion (11)(q23).
We report a case of chronic neutrophilic leukemia (CNL) in a 68-year-old man. Karyotype showed a clonal abnormality, never described before in CNL: 46,XY,del(11)(q23). Southern blot analysis of the MLL gene did not reveal any rearrangement, and reverse transcriptase polymerase chain reaction (RT-PCR) analysis did not show any fusion of BCR-ABL. Treatment with hydroxyurea and cytosine arabisonide was ineffective.
Terré
C
C
Laboratoire de Cytogénétique, Hôpital André Mignot, Le Chesnay, France.
Garcia
I
I
Bastie
J N
JN
Mayeur
D
D
Decombe
L
L
Gruyer
P
P
Berger
R
R
Castaigne
S
S
D000368:Aged; D002872:Chromosome Deletion; D002880:Chromosomes, Human, Pair 11; D006801:Humans; D015467:Leukemia, Neutrophilic, Chronic / Q000235:genetics*; D008297:Male