No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease.
Recent reports have suggested that variability in the alpha2-macroglobulin gene is a genetic risk factor for Alzheimer's disease. Here we have both tested a common polymorphism in the gene (I1000V) for association with the disease in a four-site case control study design, and tested the locus for linkage in a large series of sibpairs afflicted with late onset disease. Our results fail to show an association between this polymorphism and disease.
Wavrant-DeVrièze
F
F
Mayo Clinic Jacksonville, FL 32084, USA.
Rudrasingham
V
V
Lambert
J C
JC
Chakraverty
S
S
Kehoe
P
P
Crook
R
R
Amouyel
P
P
Wu
W
W
Holmans
P
P
Rice
F
F
Pérez-Tur
J
J
Frigard
B
B
Morris
J C
JC
Carty
S
S
Cottel
D
D
Tunstall
N
N
Lovestone
S
S
Petersen
R C
RC
Chartier-Harlin
M C
MC
Goate
A
A
Owen
M J
MJ
Williams
J
J
Hardy
J
J
D017668:Age of Onset; D000483:Alleles; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D016022:Case-Control Studies; D005787:Gene Frequency; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008875:Middle Aged; D009679:Nuclear Family; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D000511:alpha-Macroglobulins / Q000235:genetics*
D001057:Apolipoproteins E; D000511:alpha-Macroglobulins