title: Effect of high-density extremely low frequency magnetic field on sister chromatid exchanges in mouse m5S cells.
abstract: The induction of sister chromatid exchanges (SCEs) was evaluated in the cultured mouse m5S cells after exposure to extremely low frequency magnetic field (ELFMF; 5, 50 and 400 mT). Exposure to 5 mT and 50 mT ELFMF led to a very small increase in the frequency of SCEs, but no significant difference was observed between exposed and unexposed control cells. The cells exposed to 400 mT ELFMF exhibited a significant elevation of the SCE frequencies. There was no significant difference between data from treatments with mitomycin-C (MMC) alone and from combined treatments of MMC plus ELFMF (400 mT) at any MMC concentrations from 4 to 40 nM. These results suggest that exposure to highest-density ELFMF of 400 mT may induce DNA damage, resulting in an elevation of the SCE frequencies. We suppose that there may be a threshold for the elevation of the SCE frequencies, that is at least over the magnetic density of 50 mT.
authors: Graduate School of Human and Environmental Studies, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.
authors: H
authors: H
authors: Yaguchi
authors: M
authors: M
authors: Yoshida
authors: Y
authors: Y
authors: Ejima
authors: J
authors: J
authors: Miyakoshi
mesh_terms: D000818:Animals; D018929:Cell Culture Techniques; D002460:Cell Line; D002470:Cell Survival / Q000528:radiation effects; D008280:Magnetics / Q000009:adverse effects*; D051379:Mice; D016685:Mitomycin / Q000633:toxicity*; D009152:Mutagenicity Tests / Q000295:instrumentation / Q000379:methods*; D009153:Mutagens / Q000633:toxicity*; D012854:Sister Chromatid Exchange / Q000528:radiation effects*
chemical_list: D009153:Mutagens; D016685:Mitomycin