[The role of HSP70 and Ca(2+)-pump from the myocardial sarcoplasmic reticulum in cardioprotective effects during adaptation to physical load in rats].
In the course of adaptation to exercise, enhanced resistance of isolated heart against ischemia and reperfusion correlated with accumulation of cytoprotective proteins of the HSP70 family and increased potency of sarcoplasmic reticulum (SR) Ca2+ pump in the rat myocardium. Blockade of the HSP70 synthesis with guercetin prevented development of protection of the heart against ischemia and reperfusion. In the course of the adaptation, the increased resistance of the Ca2+ pump against detrimental factors preceded its potentiation. The findings suggest that the HSP70 accumulation and increased potency and resistance of the SR Ca2+ transport system in the myocardium are important mechanisms of adaptive protection of the heart.
Pshennikova
M G
MG
Research Institute of General Pathology and Pathophysiology, Russian Acad. Med. Sci., Moscow, Russia.
Prodius
P A
PA
Sazontova
T G
TG
Golantsova
N E
NE
Malyshev
I Iu
IIu
D000222:Adaptation, Physiological; D000818:Animals; D000252:Calcium-Transporting ATPases / Q000502:physiology*; D018840:HSP70 Heat-Shock Proteins / Q000502:physiology*; D008297:Male; D009200:Myocardial Contraction; D017202:Myocardial Ischemia / Q000378:metabolism / Q000503:physiopathology; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000503:physiopathology; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism* / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar; D012519:Sarcoplasmic Reticulum / Q000201:enzymology / Q000378:metabolism*; D013312:Stress, Physiological / Q000378:metabolism / Q000503:physiopathology*
D018840:HSP70 Heat-Shock Proteins; D000252:Calcium-Transporting ATPases