title: Biophysical and biochemical properties of oligodeoxy-nucleotides containing 4'-C- and 5'-C-substituted thymidines.
abstract: We have previously reported oligodeoxynucleotides (ODNs) containing 4'-C- and 5'-C-substituted thymidines, which demonstrated certain favorable biophysical and biochemical properties. In this communication, the hybridization and nuclease stability data of the ODNs along with their capability to induce RNase H activity are presented.
authors: Research Department, ICN Pharmaceuticals, Inc., Costa Mesa, CA 92626, USA.
authors: G
authors: G
authors: Wang
authors: P J
authors: PJ
authors: Middleton
authors: C
authors: C
authors: Lin
authors: Z
authors: Z
authors: Pietrzkowski
mesh_terms: D015703:Antigens, CD / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008956:Models, Chemical; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D018123:Receptors, Interleukin / Q000378:metabolism; D023062:Receptors, Interleukin-8A; D016914:Ribonuclease H / Q000378:metabolism; D013936:Thymidine / Q000737:chemistry*
chemical_list: D015703:Antigens, CD; D009841:Oligonucleotides; D018123:Receptors, Interleukin; D023062:Receptors, Interleukin-8A; D016914:Ribonuclease H; D013936:Thymidine