Synthesis of glucuronides of multidrug resistance reversing drug MS-209.
We synthesized the glucuronides of MS-209 to identify the two main unknown metabolites in human urine. Reaction of MS-209 and glucuronyl trichloroacetimidate gave two beta-isomers, which were each glucuronate of (R)- and (S)-MS-209. These spectrum data were identical with the metabolites.
Suzuki
T
T
Life Sciences Laboratory, Performance Materials R&D Center, Mitsui Chemicals, Inc., Mobara, Chiba, Japan.
Mabuchi
K
K
Fukazawa
N
N
D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism* / Q000493:pharmacokinetics / Q000652:urine; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm / Q000502:physiology; D005965:Glucuronates / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology / Q000652:urine; D006801:Humans; D011804:Quinolines / Q000737:chemistry / Q000378:metabolism* / Q000493:pharmacokinetics / Q000652:urine
D000970:Antineoplastic Agents; D005965:Glucuronates; D011804:Quinolines; C087719:dofequidar