title: Differences between relapsing-remitting and chronic progressive multiple sclerosis as determined with quantitative MR imaging.
abstract: OBJECTIVE
  To investigate the cross-sectional relationships among multiple quantitative brain magnetic resonance (MR) imaging measurements in patients with relapsing-remitting versus chronic progressive multiple sclerosis (MS).
  
  
  METHODS
  Thirty-eight patients with MS (relapsing-remitting, 26, chronic progressive, 12) were examined. Lesion volume on T2-weighted MR images, contrast material-enhancing lesion volume, percentage of brain parenchymal volume (brain volume/[brain volume + cerebrospinal fluid volume), and magnetization transfer ratio histogram peak height for the whole brain were calculated.
  
  
  RESULTS
  Significant negative correlation was noted between volume on T2-weighted images and magnetization transfer ratio histogram peak height for both the relapsing-remitting and chronic progressive groups (P < .001 for both). A positive correlation was demonstrated for lesion volume on T2-weighted images and enhancing lesion volume in the relapsing-remitting group (P < .01) but not in the chronic progressive group. Negative correlations were demonstrated for enhancing lesion volume and magnetization transfer ratio histogram peak height (P = .02), for Expanded Disability Status Scale score and magnetization transfer histogram peak height (P = .02), and for Expanded Disability Status Scale score and percentage of brain parenchymal volume in the relapsing-remitting group (P = .004) but not in the chronic progressive group.
  
  
  CONCLUSIONS
  The cross-sectional relationships among multiple quantitative brain MR imaging measurements are different between relapsing-remitting and chronic progressive MS.
authors: Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia 19104-4283, USA.
authors: Y
authors: Y
authors: Miki
authors: R I
authors: RI
authors: Grossman
authors: J K
authors: JK
authors: Udupa
authors: M A
authors: MA
authors: van Buchem
authors: L
authors: L
authors: Wei
authors: M D
authors: MD
authors: Phillips
authors: U
authors: U
authors: Patel
authors: J C
authors: JC
authors: McGowan
authors: D L
authors: DL
authors: Kolson
mesh_terms: D000328:Adult; D019412:Anatomy, Cross-Sectional; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000473:pathology*; D002555:Cerebrospinal Fluid; D002908:Chronic Disease; D003287:Contrast Media; D006233:Persons with Disabilities / Q000145:classification; D018450:Disease Progression; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000503:physiopathology; D009103:Multiple Sclerosis / Q000473:pathology* / Q000503:physiopathology; D011446:Prospective Studies; D012008:Recurrence
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA