title: Six-week treatment with Ukrain in rabbits. Part II: Serum levels of gonadal hormones.
abstract: The effect of 6-week treatment with Ukrain at doses of 0.3, 1.5, and 3.0 mg/kg i.v. on the serum levels of steroid hormones, i.e., estradiol, testosterone, and progesterone, was studied in rabbits of both sexes. It is demonstrated that Ukrain treatment exerts minor changes in serum hormone levels. The level of estradiol was increased in the serum of male rabbits following Ukrain treatment only at the dose of 1.5 mg/kg i.v. Similarly, the estradiol serum level was increased after Ukrain given at 1.5 mg/kg i.v. in female rabbits. In male rabbits Ukrain application at 0.3 mg/kg i.v. increased the serum testosterone level. Serum testosterone levels were not altered following Ukrain administration up to 3.0 mg/kg i.v. in female rabbits. Ukrain raised the serum progesterone levels in male rabbits at the doses of 0.3 and 3.0 mg/kg i.v. in females, only the highest dose of Ukrain produced a significant increase of serum progesterone.
authors: Department of Pharmacology and Toxicology, Medical University School, Lublin, Poland.
authors: E
authors: E
authors: Jagiello-Wójtowicz
authors: Z
authors: Z
authors: Kleinrok
authors: M
authors: M
authors: Feldo
authors: A
authors: A
authors: Chodkowska
authors: V
authors: V
authors: Szklarczyk
authors: E M
authors: EM
authors: Urbanska
mesh_terms: D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001600:Berberine Alkaloids; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000097:blood; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood*; D008297:Male; D010617:Phenanthridines; D011374:Progesterone / Q000097:blood; D011817:Rabbits; D013739:Testosterone / Q000097:blood; D013997:Time Factors
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D001600:Berberine Alkaloids; D012739:Gonadal Steroid Hormones; D010617:Phenanthridines; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; C060921:ukrain