RNA splicing: What has phosphorylation got to do with it?
Many pre-mRNA splicing factors are phosphorylated in vivo, but the role of this modification has been unclear. Recent observations suggest that phosphorylation modulates protein-protein interactions within the spliceosome, thereby contributing to dynamic structural reorganization of the spliceosome during splicing.
Misteli
T
T
National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. mistelit@mail.nih.gov
D000818:Animals; D005057:Eukaryotic Cells / Q000378:metabolism; D008957:Models, Genetic; D009687:Nuclear Proteins / Q000737:chemistry* / Q000502:physiology; D010749:Phosphoprotein Phosphatases / Q000502:physiology*; D010766:Phosphorylation; D011494:Protein Kinases / Q000502:physiology*; D011499:Protein Processing, Post-Translational; D012322:RNA Precursors / Q000378:metabolism*; D012326:RNA Splicing; D016601:RNA-Binding Proteins; D017411:Ribonucleoproteins, Small Nuclear / Q000502:physiology; D000068103:Serine-Arginine Splicing Factors; D017381:Spliceosomes / Q000502:physiology
D009687:Nuclear Proteins; D012322:RNA Precursors; D016601:RNA-Binding Proteins; D017411:Ribonucleoproteins, Small Nuclear; D000068103:Serine-Arginine Splicing Factors; D011494:Protein Kinases; D010749:Phosphoprotein Phosphatases