title: Lung air spaces: MR imaging evaluation with hyperpolarized 3He gas.
abstract: Thirty-two magnetic resonance imaging examinations of the lungs were performed in 16 subjects after inhalation of 1-2 L of helium 3 gas that was laser polarized to 10%-25%. The distribution of the gas was generally uniform, with visualization of the fissures in most cases. Ventilation defects were demonstrated in smokers and in a subject with allergies. The technique has potential for evaluating small airways disease.
authors: Department of Radiology, University of Virginia Health Sciences Center, Charlottesville 22908, USA.
authors: E E
authors: EE
authors: de Lange
authors: J P
authors: JP
authors: Mugler
authors: J R
authors: JR
authors: Brookeman
authors: J
authors: J
authors: Knight-Scott
authors: J D
authors: JD
authors: Truwit
authors: C D
authors: CD
authors: Teates
authors: T M
authors: TM
authors: Daniel
authors: P L
authors: PL
authors: Bogorad
authors: G D
authors: GD
authors: Cates
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D000368:Aged; D001249:Asthma / Q000473:pathology; D005260:Female; D006371:Helium / Q000008:administration & dosage; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007554:Isotopes; D007834:Lasers; D008168:Lung / Q000473:pathology* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D010100:Oxygen / Q000097:blood; D011656:Pulmonary Emphysema / Q000473:pathology; D012119:Respiration; D006255:Rhinitis, Allergic, Seasonal / Q000473:pathology; D012907:Smoking / Q000473:pathology
chemical_list: D007554:Isotopes; D006371:Helium; D010100:Oxygen