title: High-intensity basal ganglia lesions on T1-weighted images in two toddlers with elevated blood manganese with portosystemic shunts.
abstract: We report two toddlers with portosystemic shunts who had symmetrical high-signal globus pallidus lesions on T1- but not T2-weighted MRI, and measurement of whole blood manganese at 2 years of age. These cases suggest that portosystemic shunts can cause elevation of blood manganese and result in manganese accumulation in the globus pallidus, causing high signal on T1-weighted images even in asymptomatic toddlers.
authors: Department of Pediatrics, Faculty of Medicine, Kyushu University, Fukuoka, Japan. k-ihara@mailserver.med.kyushu-u.ac.jp
authors: K
authors: K
authors: Ihara
authors: T
authors: T
authors: Hijii
authors: R
authors: R
authors: Kuromaru
authors: M
authors: M
authors: Ariyoshi
authors: R
authors: R
authors: Kira
authors: J
authors: J
authors: Fukushige
authors: T
authors: T
authors: Hara
mesh_terms: D001927:Brain Diseases / Q000175:diagnosis; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D005693:Galactosemias / Q000150:complications / Q000209:etiology; D005917:Globus Pallidus / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008345:Manganese / Q000097:blood*; D011169:Portal Vein / Q000002:abnormalities*
chemical_list: D008345:Manganese