title: The influence of short-term endurance training on the insulin blood level, binding, and degradation of 125I-insulin by erythrocyte receptors in patients after myocardial infarction.
abstract: OBJECTIVE
  This study was directed toward establishing whether and to what extent, short-term endurance training influences the insulin blood level, and the binding and degradation of 125I-insulin by erythrocyte receptors in patients undergoing rehabilitation after myocardial infarction.
  
  
  METHODS
  The study was conducted in a group of 60 patients who had had myocardial infarction within the past 1.5 to 3 months and who did not have arterial hypertension and diabetes mellitus. All the patients took a symptom-limited cardiopulmonary exercise test. Before and after the test, venous blood was collected to determine lactic acid and insulin blood levels as well as the binding and degradation of 125I-insulin. The study group was randomized into two subgroups. One subgroup entered into a 3-week in-patient rehabilitation course. The control group was discharged from the hospital and was given no recommendations for physical exercise. The same investigation was repeated 3 weeks later.
  
  
  RESULTS
  In the patients (50%) with hyperinsulinemia (insulin resistance index, > 10 microIU/mL), which was detected during the first investigation, insulin blood level decreased from 23.9 +/- 4.4 to 15.0 +/- 1.9 microIU/mL (P < 0.05) after rehabilitation, whereas insulin binding increased from 0.67 +/- 0.05 to 0.85 +/- 0.08 pg 125I/10(11) erythrocytes (P < 0.05). In the control group, which included normal subjects and those with hyperinsulinemia, the results obtained during the first and second investigations showed no statistically significant changes when compared.
  
  
  CONCLUSIONS
  The results suggest that a 3-week endurance training period during rehabilitation after myocardial infarction reduces insulin resistance in patients with hyperinsulinemia.
authors: University School of Physical Education, Department of Cardiac Rehabilitation, Poznań, Poland.
authors: P
authors: P
authors: Dylewicz
authors: I
authors: I
authors: Przywarska
authors: L
authors: L
authors: Szcześniak
authors: T
authors: T
authors: Rychlewski
authors: S
authors: S
authors: Bieńkowska
authors: I
authors: I
authors: Długiewicz
authors: M
authors: M
authors: Wilk
mesh_terms: D000328:Adult; D003627:Data Interpretation, Statistical; D004912:Erythrocytes / Q000378:metabolism*; D005080:Exercise Test; D006801:Humans; D006946:Hyperinsulinism / Q000175:diagnosis; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D007333:Insulin Resistance; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000534:rehabilitation*; D010806:Physical Education and Training; D010807:Physical Endurance; D011972:Receptor, Insulin / Q000378:metabolism*; D013997:Time Factors
chemical_list: D007328:Insulin; D007457:Iodine Radioisotopes; D011972:Receptor, Insulin