title: Differential expression of c-fos mRNA in the rat neocortex by in situ hybridization.
abstract: The c-fos mRNA expression pattern in rat neocortex, was determined in the rat kept in a 12:12 light/dark cycle, in constant dark, or in constant light by in situ hybridization. At the beginning of the light period, c-fos mRNA was induced both in the neocortex and suprachiasmatic nucleus (SCN). Transiently increased c-fos mRNA expression was detected from 0830 to 0900 and soon declined to basal levels. Immediately prior to the beginning of the dark period, c-fos mRNA expression also increased and remained elevated in the neocortex following the dark period. In the constant dark group, c-fos mRNA expression showed no transient elevation at the beginning of the light period. On the other hand, c-fos mRNA expression in the constant light group increased during their subjective dark period as well as normal light/dark cycle. These results demonstrate a circadian pattern of c-fos mRNA expression in the neocortex which is similar to that observed previously in the inner and outer nuclear layers of the retina.
authors: Department of Anatomy, Nippon Medical School, Tokyo, Japan.
authors: H
authors: H
authors: Onodera
authors: J
authors: J
authors: Imaki
authors: K
authors: K
authors: Yoshida
authors: K
authors: K
authors: Yamashita
mesh_terms: D000818:Animals; D002940:Circadian Rhythm; D016762:Genes, fos; D017403:In Situ Hybridization; D008297:Male; D019579:Neocortex / Q000378:metabolism*; D012333:RNA, Messenger / Q000032:analysis*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D012333:RNA, Messenger