title: Sino-aortic denervation augments the increase in blood pressure seen during paradoxical sleep in the rat.
abstract: Using a computer assisted telemetric system, we have re-examined the effect of sino-aortic denervation (SAD) on the changes in arterial blood pressure (AP) and heart rate (HR) during sleep in the rat suitably recovered from the operation. Eight 1 hourly polygraphic recordings were performed 4 weeks after the initial SAD surgery. In the SAD rats, the increase in AP during paradoxical sleep (PS) was much larger than that in sham-operated rats. HR in the SAD rats increased on-going from slow-wave sleep to PS, but it showed no change in sham-operated rats. The present study suggests that chronic SAD causes the enhanced AP increase during PS concomitantly with the persistent hypertension and tachycardia across sleep-wake states.
authors: Department of Physiology, School of Medicine, University of Tokushima, Japan.
authors: H
authors: H
authors: Sei
authors: Y
authors: Y
authors: Morita
authors: K
authors: K
authors: Tsunooka
authors: H
authors: H
authors: Morita
mesh_terms: D000818:Animals; D017763:Autonomic Denervation; D004195:Disease Models, Animal; D006973:Hypertension / Q000175:diagnosis*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012850:Sinus of Valsalva / Q000294:innervation*; D012895:Sleep, REM / Q000502:physiology*; D013610:Tachycardia / Q000175:diagnosis; D014851:Wakefulness