Regulation of LEF-1/TCF transcription factors by Wnt and other signals.
LEF-1/TCF transcription factors mediate a nuclear response to Wnt signals by interacting with beta-catenin. Wnt signaling and other cellular events that increase the stability of beta-catenin result in transcriptional activation by LEF-1/TCF proteins in association with beta-catenin. In the absence of Wnt signaling, LEF-1/TCF proteins repress transcription in association with Groucho and CBP. The LEF-1/TCF transcription factors can also interact with other cofactors and play an architectural role in the assembly of multiprotein enhancer complexes, which may allow for the integration of multiple signaling pathways.
Eastman
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Howard Hughes Medical Institute, Department of Microbiology and Immunology, 513 Parnassus Avenue, University of California San Francisco, CA 94143, USA.
Grosschedl
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D000818:Animals; D002448:Cell Adhesion; D003598:Cytoskeletal Proteins / Q000502:physiology; D004268:DNA-Binding Proteins / Q000502:physiology*; D029721:Drosophila Proteins; D051157:Frizzled Receptors; D005786:Gene Expression Regulation / Q000502:physiology*; D015801:Helminth Proteins / Q000502:physiology; D019476:Insect Proteins / Q000502:physiology; D051821:Lymphoid Enhancer-Binding Factor 1; D008565:Membrane Proteins / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D008957:Models, Genetic; D009687:Nuclear Proteins / Q000502:physiology; D011506:Proteins / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000502:physiology; D043562:Receptors, G-Protein-Coupled; D011993:Recombinant Fusion Proteins / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D015534:Trans-Activators; D014157:Transcription Factors / Q000502:physiology*; D014158:Transcription, Genetic / Q000502:physiology*; D051153:Wnt Proteins; D029961:Zebrafish Proteins; D051176:beta Catenin
C495267:CTNNB1 protein, mouse; D003598:Cytoskeletal Proteins; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D051157:Frizzled Receptors; D015801:Helminth Proteins; D019476:Insect Proteins; C497574:Lef1 protein, mouse; D051821:Lymphoid Enhancer-Binding Factor 1; D008565:Membrane Proteins; D009687:Nuclear Proteins; D011506:Proteins; D011518:Proto-Oncogene Proteins; D043562:Receptors, G-Protein-Coupled; D011993:Recombinant Fusion Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D051153:Wnt Proteins; D029961:Zebrafish Proteins; D051176:beta Catenin; C058784:fz protein, Drosophila