Synthesis and characterization of self-catalyzed poly(ortho-esters) based on decanediol and decanediol-lactate.
The synthesis of poly(ortho-esters) (POEs) containing lactic acid dimers in the polymer backbone for possible use in controlled drug release applications is described. These autocatalyzed POEs are prepared by the acid catalyzed condensation of 3,9-diethylidene-2,4,8,10-tetraoxaspiro(5,5)undecane with diols to produce linear polymers. The diols used were a mixture of decanediol-lactate and decanediol in various molar ratio to produce polymers with different lactic acid contents. Polymer structures were confirmed by 13C NMR, 1H NMR, and FT-IR and physico-chemical properties, such as molecular weights, glass transition temperatures and viscoelastic behavior, were also determined.
Schwach-Abdellaoui
K
K
School of Pharmacy, University of Geneva, Switzerland.
Heller
J
J
Gurny
R
R
D002152:Calorimetry, Differential Scanning; D002250:Carbon Radioisotopes; D002384:Catalysis; D002845:Chromatography / Q000379:methods; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism*; D005233:Fatty Alcohols / Q000737:chemistry; D007773:Lactates / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry*; D012212:Rheology; D017550:Spectroscopy, Fourier Transform Infrared; D014316:Tritium
C118976:1,10-decanediol-lactate; D002250:Carbon Radioisotopes; D004337:Drug Carriers; D005233:Fatty Alcohols; D007773:Lactates; D011091:Polyesters; D014316:Tritium; C118975:1,10-decanediol