Antigen-based immunotherapy for autoimmune disease: from animal models to humans?
Insights into tolerance and autoimmune processes have led to novel immunotherapeutics for inhibiting autoimmune disease in animal models. However, recent studies question the immune basis of some of these therapeutic strategies and raise concerns about their efficacy and safety. Here, we discuss the feasibility of extending the success of antigen-based immunotherapeutics for T-cell-mediated autoimmune diseases from animal models to humans.
Tian
J
J
Dept of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095-1735, USA.
Olcott
A
A
Hanssen
L
L
Zekzer
D
D
Kaufman
D L
DL
D000818:Animals; D001324:Autoantigens / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy*; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D006801:Humans; D007108:Immune Tolerance; D007167:Immunotherapy / Q000379:methods; D013601:T-Lymphocytes / Q000276:immunology
D001324:Autoantigens