Sarcoidosis presenting as a tumorlike muscular lesion. Case report and review of the literature.
Sarcoid myopathy presenting as a tumorlike lesion is an exceedingly rare presentation of sarcoidosis. Concurrent extramuscular involvement is common. Chest radiographs, if abnormal, may suggest the diagnosis. Magnetic resonance imaging is the preferred study for diagnosis and follow-up of tumorous sarcoid myopathy. Optimal therapy is not clear. Favorable responses have been cited with surgery or corticosteroids (alone or in combination). Azathioprine or alternative immunosuppressive agents (for example, antimalarials or methotrexate) may have a role in corticosteroid-recalcitrant patients. The role of local radiotherapy is controversial and should be reserved for severe localized disease refractory to aggressive medical therapy.
Zisman
D A
DA
Department of Internal Medicine, University of Michigan, Ann Arbor, USA.
Biermann
J S
JS
Martinez
F J
FJ
Devaney
K O
KO
Lynch
J P
JP
D005260:Female; D006801:Humans; D007866:Leg; D008875:Middle Aged; D009135:Muscular Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D012507:Sarcoidosis / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology