Nephroblastoma in experience of pediatrics clinic from Cluj-Napoca between 1974-1997--a clinical and anatomopathological approach.
Based on a retrospective analysis of 60 cases of nephroblastoma, the author reaches the following conclusions: 1) correct diagnosis and treatment of the nephroblastoma depend on the team-work involving the surgeon, the chemotherapist and the pathologist; 2) during the macroscopic analysis the pathologist is asked to: establish/determine if the tumor penetrates the renal capsule, establish the tumor invasion into the renal sinus vessels, establish if the medial limit of the renal sinus is occupied or not by the tumor and, include the nephrectomy specimens in the category over or below 550 g; 3) during the microscopical analysis the pathologist is asked to: actually make the positive diagnosis of nephroblastoma, identify the presence or the absence of the diffuse or focal anaplasia; and 4) based on this data the surgeon will complete the staging while the chemotherapist will choose a certain protocol depending on the stage and on the presence or absence of the anaplasia.
Ples
R
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Department of Pathology, Children's Hospital, Cluj-Napoca, Romania.
D000708:Anaplasia; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis; D012383:Romania; D009396:Wilms Tumor / Q000175:diagnosis / Q000473:pathology*