[Hereditary risks of breast cancer. Interaction of genetic factors and hormonal factors].
The association between risk of breast cancer and familial risk is well documented. The first observation was described by Paul Broca around 1850 from his own family. Germinal mutations have been estimated to account for 5 to 10% of breast cancer cases. However, some questions remains unclear in this context of a multifactorial disease. Even if the rise in breast cancer risk associated with BRCAx mutations is well established, the place of a genetic factor among other factors risks of breast cancer remains unclear. The interaction between genetic, environmental and hormonal factors is an important problem. More particularly the effect of oral contraceptives and hormonal replacement therapy in women with or without hereditary susceptibility of breast cancer needs to be addressed.
Plu-Bureau
G
G
Service Endocrinologie Médecine de la reproduction, Hôpital Necker, Paris.
Thalabard
J C
JC
D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics*; D003276:Contraceptives, Oral; D015914:Estrogen Replacement Therapy; D005260:Female; D019398:Genes, BRCA1; D006728:Hormones; D006801:Humans; D012307:Risk Factors
D003276:Contraceptives, Oral; D006728:Hormones