Genetic correlation in otosclerosis.
OBJECTIVE
The aim of this study was to determine the relationship of HLA typing in patients with otosclerosis.


METHODS
We used a prospective study in which HLA typing of 100 surgically confirmed otosclerosis patients were compared with age and sex matched normal individuals.


RESULTS
HLA-A3, HLA-A9, HLA-A11, and HLA-B13 were found to be significantly higher (P < .05, .01, and .01, respectively). HLA-A9 and HLA-A11 were found to be higher (P < .01) in patients with a positive family history, indicating genetic heterogenicity.


CONCLUSIONS
Higher values of HLA-A9, HLA-11, and HLA-B13 in patients with otosclerosis compared with normal individuals strongly suggests a genetic, HLA-related component.
Singhal
S K
SK
Department of Otolaryngology and Head & Neck Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Mann
S B
SB
Datta
U
U
Panda
N K
NK
Gupta
A K
AK
D000293:Adolescent; D000328:Adult; D000939:Epitopes; D005260:Female; D006680:HLA Antigens / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D008875:Middle Aged; D010040:Otosclerosis / Q000235:genetics*; D011446:Prospective Studies
D000939:Epitopes; D006680:HLA Antigens