Developmental expression of the murine Prl-1 protein tyrosine phosphatase gene.
The expression of the murine Prl-1 protein tyrosine phosphatase gene was examined in normal embryos from E10.5 through E18.5. Prl-1 mRNA was detected in the brain, neural tube, and dorsal root ganglia, and in several non-neuronal tissues, including the skeletal system. Heart and skeletal muscle were consistently negative. At E13.5, Prl-1 was expressed in the condensing prechondrogenic cells of the vertebrae, whereas at E18.5, Prl-1 mRNA was localized to the hypertrophic chondrocytes. The dynamic expression of Prl-1 during cartilage differentiation may suggest a functional role in skeletal development.
Rundle
C H
CH
Department of Biochemistry and Molecular Biology, S.C. Johnson Medical Research Center, Mayo Clinic Scottsdale, Arizona 85259, USA.
Kappen
C
C
D000595:Amino Acid Sequence; D000818:Animals; D001842:Bone and Bones / Q000201:enzymology; D001921:Brain / Q000201:enzymology; D002356:Cartilage / Q000201:enzymology* / Q000254:growth & development; D018507:Gene Expression Regulation, Developmental; D005801:Genes, Homeobox / Q000235:genetics; D051379:Mice; D008969:Molecular Sequence Data; D017027:Protein Tyrosine Phosphatases / Q000235:genetics* / Q000378:metabolism
D017027:Protein Tyrosine Phosphatases