Coagulation and fibrinolysis in children, adolescents, and young adults with inflammatory bowel disease.
BACKGROUND
Patients with Crohn's disease and ulcerative colitis have an increased risk of thromboembolic events.


METHODS
Data were collected from 24 patients aged 4.5 to 23 years who had inflammatory bowel disease. Platelet count, antithrombin, fibrinogen, prothrombin fragment F1+2, soluble thrombomodulin, tissue plasminogen activator, D-dimer, and plasminogen activator inhibitor-1 antigen were investigated. In addition the response to activated protein C, the factor V R506Q mutation, protein C, free protein S antigen, and lipoprotein (a) were analyzed. These data were compared with medical treatment, duration, and disease activity, estimated with the Pediatric Crohn's Disease Activity Index or the Clinical Colitis Activity Index.


RESULTS
Forty-five percent of our patients showed an increase in fibrinogen, 29% in prothrombin fragment F1+2, and 20% in platelet count, plasminogen activator inhibitor- antigen, and soluble thrombomodulin. Thrombomodulin was higher in active disease than in inactive disease and in Crohn's disease than in ulcerative colitis. Fibrinogen was also higher with Crohn's disease and tended to be higher in active disease than in ulcerative colitis and inactive disease. Plasminogen activator inhibitor-1 antigen was significantly higher in patients with Crohn's disease than in those with ulcerative colitis and was higher in the patient group treated with steroids.


CONCLUSIONS
As has been shown in adults, young patients with active and inactive inflammatory bowel disease were found to have abnormal coagulation and fibrinolysis. The relevance as a thromboembolic risk factor is discussed.
Weber
P
P
University Children's Hospital, Münster, Germany.
Husemann
S
S
Vielhaber
H
H
Zimmer
K P
KP
Nowak-Göttl
U
U
D000293:Adolescent; D000328:Adult; D001777:Blood Coagulation; D002648:Child; D002675:Child, Preschool; D003093:Colitis, Ulcerative / Q000097:blood*; D003424:Crohn Disease / Q000097:blood*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D005342:Fibrinolysis; D006801:Humans; D008297:Male; D010446:Peptide Fragments / Q000378:metabolism; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D010976:Platelet Count; D011516:Prothrombin / Q000378:metabolism; D018180:Thrombomodulin / Q000097:blood
D010446:Peptide Fragments; D017395:Plasminogen Activator Inhibitor 1; D018180:Thrombomodulin; C045879:prothrombin fragment 1.2; D011516:Prothrombin; D005340:Fibrinogen