Neuroprotective effects of acetylsalicylic acid in an animal model of focal brain ischemia.
Recent studies have shown neuroprotective effects of acetylsalicylic acid (ASA) in cell cultures and hippocampal slices. The present study demonstrates similar effects in a whole-animal modal of focal ischemic stroke. Focal cortical ischemia was produced in Wistar rats by ligation of the common carotid and middle cerebral arteries. Subjects were sacrificed 8 days after ligation, and infarct volume was assessed via automated densitometry. Significant reductions in infarct volume were seen with i.p. ASA doses of 15 mg/kg and above. Reductions occurred when ASA was injected 2 h or 30 min before ligation, but not when it was injected 8 or 24 h before, or 30 min after ligation.
Khayyam
N
N
Department of Pharmacology, University of Toronto, ON, Canada.
Thavendiranathan
P
P
Carmichael
F J
FJ
Kus
B
B
Jay
V
V
Burnham
W M
WM
D000818:Animals; D001241:Aspirin / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects / Q000473:pathology; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology*; D002544:Cerebral Infarction / Q000473:pathology; D008297:Male; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D018696:Neuroprotective Agents; D001241:Aspirin