Effect of a microwave coagulator on implanted liver neoplasms in rats.
An experimental study was conducted to determine the applicability of a microwave (MW) source for coagulation and dissection of metastatic tumour and liver parenchyma. Twenty PVG rats were studied after implantation of MC28 tumour cells into the liver. Eleven days later they underwent sham laparotomy (control) MW coagulation of the tumour deposit, local resection of the tumour deposit with 2 mm clearance or resection of the tumour with MW coagulation of the resection zone. The control animals all died with blood-stained ascites and heavy tumour burden in the liver. After MW coagulation, tumours disappeared in all but one rat. Local resection also led to tumour clearance in 4 of 5 rats. MW coagulation of the resection zone allowed rapid bloodless resection, and no tumour recurrence was observed after 40-89 days. We conclude that MW coagulation is a potentially useful tool for ablation of hepatic metastasis and as an adjunct to hepatic resection.
Chen
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Department of Surgery, Third Hospital and School of Clinical Medicine of Beijing Medical University, Beijing, China.
Cooper
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Taylor
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Johnson
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D000818:Animals; D003131:Combined Modality Therapy; D004195:Disease Models, Animal; D004564:Electrocoagulation / Q000379:methods*; D007813:Laparotomy / Q000379:methods; D008099:Liver / Q000473:pathology* / Q000601:surgery; D008114:Liver Neoplasms, Experimental / Q000601:surgery*; D008872:Microwaves / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D012513:Sarcoma, Experimental / Q000601:surgery*; D016896:Treatment Outcome