title: Model for the regulation of energy balance and adiposity by the central nervous system.
abstract: In 1995, we described a new model for adiposity regulation. Since then, data regarding the biology of body weight regulation has accumulated at a remarkable rate and has both modified and strengthened our understanding of this homeostatic system. In this review we integrate new information into a revised model for further understanding this important regulatory process. Our model of energy homeostasis proposes that long-term adiposity-related signals such as insulin and leptin influence the neuronal activity of central effector pathways that serve as controllers of energy balance.
authors: Department of Medicine, University of Washington, Harborview-Medical Center and the VA Puget Sound Health Care System, Seattle 98108, USA. mschwart@u.washington.edu
authors: M W
authors: MW
authors: Schwartz
authors: D G
authors: DG
authors: Baskin
authors: K J
authors: KJ
authors: Kaiyala
authors: S C
authors: SC
authors: Woods
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D019167:Appetite Stimulants; D001835:Body Weight; D004734:Energy Metabolism; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007031:Hypothalamus / Q000502:physiology; D008954:Models, Biological; D009478:Neuropeptide Y / Q000502:physiology
chemical_list: D019167:Appetite Stimulants; D009478:Neuropeptide Y