title: Nonsurgical management of gallstone disease.
abstract: Cholelithiasis is a common disease in the United States associated with significant morbidity. Surgical treatment with cholecystectomy has been increasing with a significant cost to the health care system. Surgical management is not without risk. Cholecystectomy has also been associated with a significant morbidity and mortality in elderly patients. Cholecystectomies are often performed unnecessarily in gallstone patients for nonspecific symptoms. Many patients with nonspecific pain, which may have a psychogenic component, continue to experience similar pain after cholecystectomy. There are problems in determining the symptom status of patients. Patients who believe surgery will relieve symptoms may maximize their symptoms, whereas patients who are reluctant to undergo surgery may minimize their symptoms. Although cholecystectomy is the mainstay of gallstone treatment, bile acid therapy and, if available, ESWL and topical dissolution are nonsurgical treatment alternatives in selected patients. In selected cases, in particular in the elderly and in other patients at increased risk from surgery, nonsurgical management offers lower morbidity and mortality than does operative treatment. The decision for surgical versus nonsurgical management should be based on both objective selection criteria and patient choice.
authors: Department of Medicine, George Washington University Medical Center, Washington, DC, USA.
authors: D E
authors: DE
authors: Howard
authors: H
authors: H
authors: Fromm
mesh_terms: D002763:Cholecystectomy; D002769:Cholelithiasis / Q000628:therapy*; D000075202:Contraindications; D006801:Humans; D008096:Lithotripsy; D008738:Methyl Ethers / Q000627:therapeutic use; D011422:Propionates / Q000627:therapeutic use; D012307:Risk Factors
chemical_list: D008738:Methyl Ethers; D011422:Propionates; C043243:methyl tert-butyl ether; C069373:ethyl propionate