NR2B-containing NMDA receptors are up-regulated in temporal cortex in schizophrenia.
Saturation analyses of [3H]L-689,560, [3H]CGP 39653 and NMDA-specific [3H]ifenprodil binding revealed an equivalent increase (0.7 pmol/mg) in the number of [3H]L-689,560 and [3H]ifenprodil binding sites in superior temporal cortex (BA22) from drug-treated chronic schizophrenic patients and control subjects. No differences were observed between control and schizophrenic subjects for [3H]CGP 39653 binding in BA22, or for any of the radioligands binding to pre-motor cortex (BA6). Since [3H]L-689,560, [3H]CGP 39653 and [3H]ifenprodil label the glycine, glutamate and ifenprodil sites of the NMDA receptor complex, which are associated with NR1, NR1/NR2A and NR1/NR2B subunits respectively, our findings suggest that NR2B-containing receptors are selectively up-regulated in superior temporal cortex in schizophrenia.
Grimwood
S
S
Merck Sharp & Dohme Neuroscience Research Laboratories, Harlow, Essex, UK.
Slater
P
P
Deakin
J F
JF
Hutson
P H
PH
D015763:2-Amino-5-phosphonovalerate / Q000031:analogs & derivatives / Q000494:pharmacology; D000634:Aminoquinolines / Q000494:pharmacology; D001665:Binding Sites / Q000502:physiology; D002102:Cadaver; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D006801:Humans; D007536:Isomerism; D010880:Piperidines / Q000494:pharmacology; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D012016:Reference Values; D012559:Schizophrenia / Q000378:metabolism*; D013702:Temporal Lobe / Q000378:metabolism*; D015854:Up-Regulation / Q000502:physiology*
D000634:Aminoquinolines; D018691:Excitatory Amino Acid Antagonists; D010880:Piperidines; D016194:Receptors, N-Methyl-D-Aspartate; C069052:CGP 39653; C074617:4-trans-2-carboxy-5,7-dichloro-4-phenylaminocarbonylamino-1,2,3,4-tetrahydroquinoline; D015763:2-Amino-5-phosphonovalerate; C010739:ifenprodil