Effects of acute hypobaric hypoxia on the appearance of ingested deuterium from a deuterium oxide-labelled carbohydrate beverage in body fluids of humans during prolonged cycling exercise.
To determine whether or not acute hypobaric hypoxia alters the rate of water absorption from a carbohydrate beverage ingested during exercise, six men cycled for 80 min on three randomly assigned different occasions. In one trial, exercise was performed in hypoxia (barometric pressure, P(B) = 594 hPa, altitude 4,400 m) at an exercise intensity selected to elicit 75% of the individual's maximal oxygen uptake (VO2max) previously determined in such conditions. In the two other experiments, the subjects cycled in normoxia (P(B) = 992 hPa) at the same absolute and the same relative intensities as in hypoxia, which corresponded to 55% and 75%, respectively, of their VO2max determined in normoxia. The subjects consumed 400 ml of a 12.5% glucose beverage just prior to exercise, and 250 ml of the same drink at 20, 40 and 60 min from the beginning of exercise. The first drink contained 20 ml of deuterium oxide to serve as a tracer for the entry of water into body fluids. The heart rate (HR) during exercise was higher in hypoxia than in normoxia at the same absolute exercise intensity, whereas it was similar to HR measured in normoxia at the same relative exercise intensity. Both in normoxia and hypoxia, plasma noradrenaline concentrations were related to the relative exercise intensity up to 40 min of exercise. Beyond that duration, when exercise was performed at the highest absolute power in normoxia, the noradrenaline response was higher than in hypoxia at the same relative exercise intensity. No significant differences were observed among experimental conditions, either in temporal profiles of plasma D accumulation or in elimination of water ingested in sweat. Conversely, elimination in urine of the water ingested appeared to be related to the severity of exercise, either high absolute power or the same relative power combined with hypoxia. We concluded that water absorption into blood after drinking a 12.5% glucose beverage is not altered during cycling exercise in acute hypobaric hypoxia. It is suggested that the elimination of water ingested in sweat and urine may be dependent on local circulatory adjustments during exercise.
Koulmann
N
N
Unité de Bioénergétique et Environment, Centre de Recherches du Service de Santé des Armées, Emile Pardé, La Tronche, France.
Melin
B
B
Bourdon
L
L
Péronnet
F
F
Jimenez
C
C
Pouzeratte
N
N
Savourey
G
G
Launay
J C
JC
Bittel
J
J
D000042:Absorption; D000531:Altitude; D001274:Atmospheric Pressure; D001628:Beverages; D001826:Body Fluids / Q000737:chemistry; D003903:Deuterium / Q000032:analysis; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D015444:Exercise; D006339:Heart Rate; D006801:Humans; D000860:Hypoxia; D007700:Kinetics; D008297:Male; D009638:Norepinephrine / Q000097:blood; D010101:Oxygen Consumption; D010953:Plasma Volume; D013542:Sweat; D014556:Urine; D014867:Water / Q000378:metabolism*
D004040:Dietary Carbohydrates; D014867:Water; D003903:Deuterium; D009638:Norepinephrine