Brain androgen-inducible aromatase is critical for adolescent organization of environment-specific social interaction in male rats.
Previous observations have indicated that specific behavioral responses to anxiogenic stimuli emerge over adolescent development in male rats and that gonadal androgens during puberty are essential for this emergence. The objective of the current study was to evaluate mechanisms via which androgens might be organizing the brain during adolescence for appropriate mature adaptive responses. Male rats were exposed to fadrozole (an aromatase inhibitor, 5 mg/kg), flutamide (an androgen receptor antagonist, 10 mg/kg), or MK-434 (a 5 alpha-reductase inhibitor, 10 mg/kg) from day 29 to 60 and tested for environment-specific social interaction (SI) at 60 days of age. The emergence of adult-typical SI was impaired by exposure to the aromatase inhibitor and to the antiandrogen, whereas exposure to the 5 alpha-reductase inhibitor was without effect. Peripheral indices of drug effects indicated that the respective mechanisms had been altered by the different compounds. These results suggest that testosterone induction of aromatase is critical for the organization of mature SI behavior in male rats over adolescent development.
Kellogg
C K
CK
Department of Brain and Cognitive Sciences, University of Rochester, Rochester, New York 14627, USA.
Lundin
A
A
D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000378:metabolism; D058891:5-alpha Reductase Inhibitors; D000222:Adaptation, Physiological / Q000187:drug effects / Q000502:physiology; D000223:Adaptation, Psychological / Q000502:physiology*; D000726:Androgen Antagonists / Q000494:pharmacology; D000818:Animals; D001141:Aromatase / Q000378:metabolism*; D047072:Aromatase Inhibitors; D001835:Body Weight; D001921:Brain / Q000201:enzymology*; D001923:Brain Chemistry / Q000187:drug effects / Q000502:physiology; D013196:Dihydrotestosterone / Q000097:blood; D004791:Enzyme Inhibitors / Q000494:pharmacology; D017316:Fadrozole / Q000494:pharmacology; D018120:Finasteride / Q000031:analogs & derivatives / Q000494:pharmacology; D005485:Flutamide / Q000494:pharmacology; D008297:Male; D009929:Organ Size; D011467:Prostate / Q000502:physiology; D051381:Rats; D020318:Rats, Long-Evans / Q000502:physiology*; D011944:Receptors, Androgen / Q000502:physiology; D012741:Sexual Maturation / Q000187:drug effects / Q000502:physiology; D012930:Social Dominance; D013739:Testosterone / Q000097:blood*
C088478:17 beta-benzoyl-4-aza-5 alpha-androst-1-ene-3-one; D058891:5-alpha Reductase Inhibitors; D000726:Androgen Antagonists; D047072:Aromatase Inhibitors; D004791:Enzyme Inhibitors; D011944:Receptors, Androgen; D013196:Dihydrotestosterone; D013739:Testosterone; D018120:Finasteride; D005485:Flutamide; D001141:Aromatase; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase; D017316:Fadrozole