title: A new treatment of severe pre-eclampsia by long-term epidural anaesthesia.
abstract: We hypothesised that long term epidural anaesthesia suppresses sympathetic overactivity in pre-eclampsia. Two equal groups of severe pre-eclamptic patients were treated either with long-term epidural anaesthesia (epidural group) or bed rest, diet control, and an antihypertensive drug (control group). After 7 days of epidural block, mean arterial blood pressures decreased, platelet count and serum total protein increased in all cases while proteinuria decreased in four cases. All patients treated with a long-term epidural therapy continued their pregnancies for more than 3 weeks after admission. The infants in the epidural group had 1-min Apgar scores above 8, a body weight of 2240+/-310 g (mean +/- s.d.) and normal neonatal progress. In contrast, the pregnancies of eight patients in the control group were terminated within 2 weeks of admission due to severe pre-eclampsia or foetal distress, the birth weight of the infants was 1590+/-380 g (mean +/- s.d.) and four had neonatal distress. Progressive worsening in the mean arterial pressure, proteinuria, platelet count and serum total protein was found in these patients. Long-term epidural anaesthesia suppresses the sympathetic hyperactivity and thus improves pre-eclamptic condition which may open a new treatment in case of progressive severe pre-eclampsia.
authors: Department of Obstetrics and Gynecology, Hamamastu University School of Medicine, Hamamatsu city, Japan.
authors: N
authors: N
authors: Kanayama
authors: H M
authors: HM
authors: Belayet
authors: S
authors: S
authors: Khatun
authors: N
authors: N
authors: Tokunaga
authors: M
authors: M
authors: Sugimura
authors: T
authors: T
authors: Kobayashi
authors: T
authors: T
authors: Terao
mesh_terms: D000328:Adult; D000767:Anesthesia, Epidural; D000779:Anesthetics, Local / Q000008:administration & dosage*; D001783:Blood Flow Velocity; D001794:Blood Pressure; D002045:Bupivacaine / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007268:Injections, Epidural; D010976:Platelet Count; D011225:Pre-Eclampsia / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D016896:Treatment Outcome; D018608:Ultrasonography, Doppler; D016216:Ultrasonography, Prenatal; D014469:Umbilical Arteries / Q000000981:diagnostic imaging; D014655:Vascular Resistance
chemical_list: D000779:Anesthetics, Local; D002045:Bupivacaine