title: Improvement of pressure flow parameters with finasteride is greater in men with large prostates. Finasteride Urodynamics Study Group.
abstract: OBJECTIVE
  We assess the effect of finasteride, a 5alpha-reductase inhibitor, on objective voiding parameters in men with lower urinary tract symptoms and benign prostatic enlargement on digital rectal examination (known as clinical benign prostatic enlargement) in a double-blind placebo controlled multicenter study using strict standard pressure flow study techniques.
  
  
  METHODS
  A modification of the Abrams-Griffiths nomogram was used by 1 reader to ensure that all patients met objective criteria for bladder outlet obstruction at baseline. After performing a pressure flow study patients with obstruction were randomized 2:1 to receive 5 mg. finasteride (81) or placebo (40) daily. A second pressure flow study was performed at month 12. At baseline and month 12 free urinary flow studies and transrectal ultrasound were performed, and International Prostate Symptom Score questionnaires were completed. Patients were treated between May 1994 and July 1996.
  
  
  RESULTS
  Finasteride caused a significant decrease (-8.1 cm. water) in detrusor pressure at maximum flow (p <0.05 versus placebo p = 0.02), increase (+1.1 ml. per second) in maximum flow rate (p <0.05 versus placebo p = 0.02) and decrease (-22.8%) in prostate volume (p <0.05 versus placebo p <0.001). Men with prostates larger than 40 cc had greater improvement in detrusor pressure at maximum flow (between group difference -14.5 cm. water, 95% confidence interval -26.2 to -2.6, p = 0.02) and maximum flow rate (mean treatment effect +1.6 ml. per second, 95% confidence interval -0.2 to 3.0, p = 0.02) compared to those with prostates 40 cc or less (between group differences not significant).
  
  
  CONCLUSIONS
  Finasteride treatment resulted in improvements in urodynamic parameters, which were greater in men with large prostates.
authors: Department of Urology, Southmead Hospital, Bristol, United Kingdom.
authors: P
authors: P
authors: Abrams
authors: W
authors: W
authors: Schäfer
authors: T L
authors: TL
authors: Tammela
authors: D M
authors: DM
authors: Barrett
authors: H
authors: H
authors: Hedlund
authors: H J
authors: HJ
authors: Rollema
authors: A
authors: A
authors: Matos-Ferreira
authors: J
authors: J
authors: Nordling
authors: R
authors: R
authors: Bruskewitz
authors: J T
authors: JT
authors: Andersen
authors: T
authors: T
authors: Hald
authors: P
authors: P
authors: Miller
authors: R
authors: R
authors: Kirby
authors: S
authors: S
authors: Mustonen
authors: A
authors: A
authors: Cannon
authors: C A
authors: CA
authors: Jacobsen
authors: G J
authors: GJ
authors: Gormley
authors: M P
authors: MP
authors: Malice
authors: M A
authors: MA
authors: Bach
mesh_terms: D000368:Aged; D004311:Double-Blind Method; D018120:Finasteride / Q000494:pharmacology*; D006801:Humans; D008297:Male; D011312:Pressure; D011470:Prostatic Hyperplasia / Q000150:complications / Q000503:physiopathology*; D001748:Urinary Bladder Neck Obstruction / Q000209:etiology / Q000503:physiopathology*; D014563:Urodynamics / Q000187:drug effects*
chemical_list: D018120:Finasteride