[A comparative study of the transport dynamics of the peptide moiety of the milk ceruloplasmin molecule in the body of rats with embryonic and adult types of copper metabolism].
In chase experiments, we followed the distribution of [125I]-ceruloplasmin prepared from human breast milk orally administered to young rats. Experiments were conducted using six-day-old rat pups (the embryonic type of copper metabolism) or 35-day-old ones (the adult type of copper metabolism). Using the technique of rocket immunoelectrophoresis, we have demonstrated that in six-day-old rats [125I]-ceruloplasmin was transferred from the gastrointestinal tract to the bloodstream and could be detected there over a period of 4 h. In 35-day-old rats, milk ceruloplasmin was digested in the upper part of the intestinal tract. The dynamic aspects of the distribution of labeled milk ceruloplasmin in the body of six-day old rats over a period of 4 h point out that, under the conditions of embryonic copper metabolism, it can serve as a transporter of copper ions to extrahepatic organs. We discuss the role of milk ceruloplasmin in copper metabolism in mammals during the neonatal period.
Puchkova
L V
LV
Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg, Russia.
Aleĭnikova
T D
TD
Bichevaia
N K
NK
Mokshina
S A
SA
Platonova
N A
NA
Sasina
L K
LK
Skvortsova
N N
NN
Tsymbalenko
N V
NV
Chebotar'
N A
NA
Gaĭtskhoki
V S
VS
D000818:Animals; D000831:Animals, Newborn; D001692:Biological Transport; D002570:Ceruloplasmin / Q000032:analysis / Q000493:pharmacokinetics*; D003300:Copper / Q000378:metabolism*; D004622:Embryo, Mammalian; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008892:Milk / Q000378:metabolism*; D010455:Peptides / Q000032:analysis / Q000493:pharmacokinetics*; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution
D007457:Iodine Radioisotopes; D010455:Peptides; D003300:Copper; D002570:Ceruloplasmin