[Adherence to very active antiretroviral treatment: impact of individualized assessment].
BACKGROUND
To determine if the intervention of individual advice improves adherence and effectiveness to highly active antiretroviral therapy.


METHODS
Randomized open trial. Patients treated with zidovudine + lamivudine + indinavir were assigned (2/1) to conventional care or individual advise. Individual advise consists in adaptation to treatment to patient style of live and detailed information of therapy. Adherence were estimated with structured interview and pillo counts and were considered correct when more than 90% of prescribed drugs were taken.


RESULTS
Patients 170, conventional care: 110 and IA: 60.


RESULTS
24 weeks. Baseline characteristics were similar in both groups. Correct adherence were estimated in 52.7% of conventional care and in 76.7% of individual advise (p = 0.002, relative risk: 1.45; CI 95%: 1.16-1.82). Undetectable viral load (NASBA < 50 copies/ml) in 54.5% of conventional care and in 65% of individual advise (p = 0.18, relative risk: 1.19; CI 95%: 0.93-1.53). Reduction of viral load in the conventional care group 1.02 +/- 0.5 log10/ml, and in the individual advise group 1.98 +/- 0.7 log10/ml.


CONCLUSIONS
The individual advice improve adherence with a tendency to improve effectiveness of highly active antiretroviral therapy.
Knobel
H
H
Servicio de Medicina Interna-Infecciosas, Hospital del Mar, Universidad Autónoma de Barcelona. hernando@intercom.es
Carmona
A
A
López
J L
JL
Gimeno
J L
JL
Saballs
P
P
González
A
A
Guelar
A
A
Díez
A
A
D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D003376:Counseling; D004359:Drug Therapy, Combination; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008297:Male; D010349:Patient Compliance; D010353:Patient Education as Topic; D019562:Viral Load
D019380:Anti-HIV Agents