Phosphorylcholine: friend or foe of the immune system?
Phosphorylcholine (PC) is a structural component of a variety of prokaryotic and eukaryotic pathogens. In some cases, PC in infectious agents can benefit the infected host due to its targeting by both the innate and adaptive immune responses. However, as discussed here, PC exhibits a surprising range of immunomodulatory properties that might be to the detriment of the host.
Harnett
W
W
Dept of Immunology, University of Strathclyde, Glasgow, UK. w.harnett@strath.ac.uk
Harnett
M M
MM
D000818:Animals; D016207:Cytokines / Q000378:metabolism; D005057:Eukaryotic Cells / Q000737:chemistry; D006801:Humans; D007110:Immunity, Active; D008214:Lymphocytes / Q000378:metabolism; D010767:Phosphorylcholine / Q000276:immunology* / Q000378:metabolism; D011387:Prokaryotic Cells / Q000737:chemistry
D016207:Cytokines; D010767:Phosphorylcholine