Effect of compressional force on the crystallinity of directly compressible cellulose excipients.
The effect of compressional force on the crystallinity of low crystallinity cellulose (LCPC), microcrystalline celluloses (Avicel PH-101, PH-102 and PH-302 grades) and powdered cellulose (Solka Floc BW-100) has been investigated using an X-ray diffraction method. Microcrystalline and powdered celluloses showed an increase of about 10% in their crystallinities, compared to the values for the corresponding powders, at a compression pressure of 5-10 MPa. The increase in the crystallinity of LCPC was gradual and reached the maximum value of 5% at a compression pressure of 15 MPa. Further increase in compression pressure (to 77 MPa) had no effect on the crystallinity of LCPC, Avicel PH-101, Avicel PH-302 and Solka Floc BW-100. Avicel PH-102, on the other hand, showed a decrease in crystallinity at 15 MPa. Beyond 15 MPa, however, no statistically significant change in the crystallinity of the product was noted.
Kumar
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Division of Pharmaceutics, College of Pharmacy, University of Iowa, Iowa City 52242, USA. vijay-kumar@uiowa.edu
Kothari
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D002482:Cellulose / Q000737:chemistry*; D003460:Crystallization; D005079:Excipients / Q000737:chemistry*; D011208:Powders / Q000737:chemistry*; D014961:X-Ray Diffraction
D005079:Excipients; D011208:Powders; D002482:Cellulose