Influence of ionic strength on drug adsorption onto and release from a poly(acrylic acid) grafted poly(vinylidene fluoride) membrane.
Ion exchange resins have several applications in pharmacy for controlled or sustained release of drugs. In the present study, effects of the ionic strengths of adsorption medium and dissolution medium on drug adsorption onto and release from a acrylic acid grafted poly(vinylidene fluoride) (PAA-PVDF) were studied. Despite their porosity, PAA-PVDF membranes act reasonable well as cation exchange membranes. It was observed, that ionic strength of adsorption medium, degree of grafting and concentration of propranolol-HCl in adsorption medium affect propranolol-HCl adsorption onto the membrane. The fluxes of smaller molecules (MW < 500) across the membrane decreased with ionic strength of buffer solution, whereas the fluxes of the large molecules (FITC-dextran, MW 4400) increased with ionic strength. Release rate of adsorbed propranolol-HCl from the membrane into phosphate buffer was greatly affected by ionic strength of adsorption medium. These results can be explained by a cation exchange process between membrane and cations present in the buffer solution and swelling behavior of the grafted PAA chains.
Akerman
S
S
Department of Pharmaceutics, University of Kuopio, Finland.
Svarfvar
B
B
Kontturi
K
K
Näsman
J
J
Urtti
A
A
Paronen
P
P
Järvinen
K
K
D000179:Acrylates / Q000737:chemistry*; D000327:Adsorption; D003692:Delayed-Action Preparations / Q000493:pharmacokinetics*; D008567:Membranes, Artificial; D009994:Osmolar Concentration; D011108:Polymers / Q000737:chemistry; D011433:Propranolol / Q000493:pharmacokinetics*; D014753:Vinyl Compounds / Q000737:chemistry*
D000179:Acrylates; D003692:Delayed-Action Preparations; D008567:Membranes, Artificial; D011108:Polymers; D014753:Vinyl Compounds; C007384:1,1-difluoroethylene; D011433:Propranolol