CD8-suppressor factor and beta-chemokine function as a complementary mechanism to cognate immunity.
Protection against SIV or HIV infection requires specific antibodies and T-cell immune responses. However, a complementary mechanism may be involved, in which CD8-suppressor factors (CD8-SF) and the constitutive beta-chemokines may prevent the virus binding and replicating. Indeed, there is evidence that targeted iliac lymph node (TILN) immunisation with SIVgp120 and p27 or xenoimmunisation with SIV grown in human T-cells generates CD8-SF, RANTES, MIP-1alpha and MIP-1beta which are significantly correlated with protection from SIV infection by the rectal mucosal or intravenous route, respectively. Inhibition of SIV replication in vitro is dependent on the concentration of beta-chemokines generated by immunisation. The critical level for inhibition of SIV replication appears to be higher for rectal mucosal than intravenous challenge by SIV. The mechanism of protection in vivo has not been elucidated but it is likely that the beta-chemokines bind to CCR5 coreceptors which are internalised. Thus, CCR5 coreceptors are either blocked or not expressed on the cell surface for SIV to bind and infect.
Lehner
T
T
Department of Immunology, United Medical, School of Guy's Hospital, London, UK. t.lehner@umds.ac.uk
Wang
Y
Y
Tao
L
L
Bergmeier
L A
LA
Mitchell
E
E
Doyle
C
C
D000818:Animals; D015496:CD4-Positive T-Lymphocytes; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D019742:Chemokines, CC / Q000276:immunology*; D015683:Gene Products, gag / Q000276:immunology; D015699:HIV Envelope Protein gp120 / Q000276:immunology; D006801:Humans; D008198:Lymph Nodes / Q000276:immunology; D008253:Macaca mulatta; D008297:Male; D008562:Membrane Glycoproteins; D011994:Recombinant Proteins / Q000276:immunology; D013491:Suppressor Factors, Immunologic / Q000276:immunology*; D014611:Vaccination; D014759:Viral Envelope Proteins; D014779:Virus Replication
D019742:Chemokines, CC; C066594:Gag protein p27, Simian immunodeficiency virus; D015683:Gene Products, gag; D015699:HIV Envelope Protein gp120; D008562:Membrane Glycoproteins; D011994:Recombinant Proteins; D013491:Suppressor Factors, Immunologic; D014759:Viral Envelope Proteins; C069623:gp120 protein, Simian immunodeficiency virus