[The molecular aspects of the functional heterogeneity of the GABA receptors].
It is generally accepted that gamma-aminobutyric acid (GABA) is one of the main inhibitory transmitter in the mammalian brain. There are three types of GABA receptors in the vertebrata central nervous system: the GABAA, GABAB and GABAC receptors. The GABAA receptor is a GABA-gated Cl- channel and is the tetramer ore the pentamer made of some classes of subunit (alpha, beta, gamma, delta). GABAB receptors are not affiliated with Cl(-) ionophore. GABAB receptors appear to be coupled to Ca2+ and K+ channels of presynaptic membranes. It seems they regulate the release of neurotransmitters release. The structural and functional properties of GABA receptors are discussed.
Golovko
A I
AI
Medical Military Academy, St.-Petersburg.
Buriakova
L V
LV
Kutsenko
S A
SA
Sviderskiĭ
O A
OA
D000818:Animals; D018755:GABA Agonists / Q000494:pharmacology; D018756:GABA Antagonists / Q000494:pharmacology; D008024:Ligands; D018079:Receptors, GABA / Q000145:classification / Q000187:drug effects / Q000502:physiology*; D013329:Structure-Activity Relationship; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D018755:GABA Agonists; D018756:GABA Antagonists; D008024:Ligands; D018079:Receptors, GABA; D005680:gamma-Aminobutyric Acid