Dopaminergic synapses mediate neuronal changes in an analogue of operant conditioning.
Feeding behavior in Aplysia can be modified by operant conditioning in which contingent reinforcement is conveyed by the esophageal nerve (E n.). A neuronal analogue of this conditioning in the isolated buccal ganglia was developed by using stimulation of E n. as an analogue of contingent reinforcement. Previous studies indicated that E n. may release dopamine. We used a dopamine antagonist (methylergonovine) to investigate whether dopamine mediated the enhancement of motor patterns in the analogue of operant conditioning. Methylergonovine blocked synaptic connections from the reinforcement pathway and the contingent-dependent enhancement of the reinforced pattern. These results suggest that dopamine mediates at least part of the neuronal modifications induced by contingent reinforcement.
Nargeot
R
R
Department of Neurobiology and Anatomy and W.M. Keck Center for Neurobiology of Learning and Memory, The University of Texas-Houston Medical School, Houston, Texas 77030, USA.
Baxter
D A
DA
Patterson
G W
GW
Byrne
J H
JH
D000818:Animals; D001048:Aplysia; D003216:Conditioning, Operant / Q000502:physiology*; D004298:Dopamine / Q000502:physiology*; D005724:Ganglia / Q000166:cytology; D017952:Ganglia, Invertebrate / Q000166:cytology; D008755:Methylergonovine / Q000494:pharmacology; D009046:Motor Neurons / Q000187:drug effects / Q000502:physiology*; D009055:Mouth / Q000294:innervation; D010120:Oxytocics / Q000494:pharmacology; D010507:Periodicity; D013569:Synapses / Q000187:drug effects / Q000502:physiology*
D010120:Oxytocics; D004298:Dopamine; D008755:Methylergonovine