Cystic lymph node metastases of squamous cell carcinoma of Waldeyer's ring origin.
We analysed in a retrospective study the frequency of cystic lymph node (LN) metastases in neck dissection specimens of 123 patients with primary squamous cell carcinoma (SCC) arising in the palatine tonsils (62 M/14 F), the base of the tongue (38 M/5 F) and the nasopharynx (2 M/2 F). Eighty-two per cent of patients had metastases (64 tonsillar SCC, 33 base of tongue SCC and all four nasopharynx SCC) in 368 LN of a total 2298 sampled LN. Thirty-nine per cent of patients had exclusively solid metastases and 37% of patients had exclusively cystic metastases. A total of 62 patients had some signs of cyst formation in one or more metastatically affected LN (27 with only histological evidence of cyst formation with luminal diameters < 5 mm, 35 with clinically detectable cyst with luminal diameter > 5 mm). Cystic metastases were more common in patients with SCC of the base of the tongue (P = 0.005), while solitary clinically evident cystic metastasis with lumina > 5 mm were found exclusively in tonsillar carcinoma (P = 0.024). In comparison with solid metastases, cyst formation was associated with N-categories (N2b and N3, P = 0.005) in SCC of the base of the tongue origin. No such association was observed for tonsillar SCC (P = 0.65). The primary mechanism of cyst formation was cystic degeneration.
Regauer
S
S
Department of Pathology, University of Graz, Austria.
Mannweiler
S
S
Anderhuber
W
W
Gotschuli
A
A
Berghold
A
A
Schachenreiter
J
J
Jakse
R
R
Beham
A
A
D001935:Branchioma / Q000556:secondary*; D002294:Carcinoma, Squamous Cell / Q000556:secondary*; D003560:Cysts / Q000473:pathology; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000473:pathology*; D009333:Neck; D012189:Retrospective Studies; D014062:Tongue Neoplasms / Q000473:pathology*; D014067:Tonsillar Neoplasms / Q000473:pathology*