Heterocyclic analogs of DNA minor groove alkylating agents.
It is generally accepted that neoplastic transformation is related to genes alteration or oncogene activation. In particular, DNA minor groove binding drugs have been extensively studied through the years in order to influence the regulation of gene expression by means of specific interactions with DNA bases moieties. Pyrrolo[2,1-c],[1,4].benzodiazepines (PBDs), CC-1065 and distamycins are three classes of minor groove binders which showed interesting cytotoxicity profiles, refined through already reviewed processes of SAR studies. Among the modifications to the three families of antitumor compounds, heterocyclic substitutions have been extensively applied by many groups in order to either modify the reactivity profile or introduce extra interactions within the minor groove, thus changing the binding site or modulating the binding sequence. The updated material related to these modifications has been rationalised and ordered to offer an overview of the argument.
Baraldi
P G
PG
Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Italy. pgb@ifeuniv.unife.it
Cacciari
B
B
Guiotto
A
A
Romagnoli
R
R
Zaid
A N
AN
Spalluto
G
G
D000477:Alkylating Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D000876:Anthramycin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D001665:Binding Sites; D002626:Chemistry, Pharmaceutical; D018736:DNA Adducts; D015195:Drug Design; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D000477:Alkylating Agents; D000970:Antineoplastic Agents; D018736:DNA Adducts; D006575:Heterocyclic Compounds, 3-Ring; D000876:Anthramycin