Medical treatment of prolactinomas.
Prolactinomas are a common cause of reproductive and sexual dysfunction. Once other causes of hyperprolactinemia have been excluded with a careful history, physical examination, routine chemistries, and a TSH, MR imaging or computerized tomography will delineate the size and extent of the tumor. Medical therapy is the initial treatment of choice. When infertility is the primary indication for treatment, bromocriptine use has an extensive safety experience and is preferred. For other indications, however, cabergoline appears to be more efficacious and better tolerated. Transsphenoidal surgery remains an option, especially for patients with microadenomas, when medical therapy is ineffective.
Molitch
M E
ME
Center for Endocrinology, Metabolism and Molecular Medicine, Northwestern University Medical School, Chicago, Illinois, USA. molitch@nwu.edu
D000818:Animals; D001971:Bromocriptine / Q000627:therapeutic use; D018491:Dopamine Agonists / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000209:etiology; D009490:Neurosecretory Systems; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D011247:Pregnancy; D011388:Prolactin / Q000378:metabolism; D015175:Prolactinoma / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery
D018491:Dopamine Agonists; D001971:Bromocriptine; D011388:Prolactin