title: Serial assessment of sympathetic reinnervation after orthotopic heart transplantation. A longitudinal study using PET and C-11 hydroxyephedrine.
abstract: BACKGROUND
  Little is known about the progressiveness of sympathetic reinnervation late after cardiac transplantation (HTX). The aim of the present study was to describe individual growth of sympathetic terminals after HTX by a longitudinal quantitative assessment.
  
  
  RESULTS
  In 20 patients after HTX, dynamic PET with C-11 hydroxyephedrine (HED) was performed twice within 3.0+/-0.5 years. According to the time interval between HTX and first PET, subgroups of patients early (group A, <1.5 years; n=7), intermediate (group B, 1.5 to 7 years; n=7) and late (group C, >7 years; n=6) after HTX were defined. At the time of first HED PET, 10 patients were completely denervated (7 in group A, 2 in group B, and 1 in group C). Only 3 remained denervated at second PET. A significant increase of reinnervated myocardium between first and second PET was found in all 3 groups (0% to 9+/-9% of left ventricle for group A, P<0.05; 13+/-12% to 23+/-17% for group B, P<0.05; 21+/-21% to 37+/-23% for group C, P<0.05). The magnitude of increase was similar between groups. Reinnervation was first surveyed in the basal anterior region, then toward apex, septal, and lateral wall. Inferior wall remained denervated. The largest reinnervated area surveyed in an individuum was 66% of the left ventricle.
  
  
  CONCLUSIONS
  The present data confirm the low likelihood of sympathetic reinnervation within 18 months after HTX. Once the reinnervation process is initiated, a continuous growth is observed even late after HTX, suggesting a progressive nature of reinnervation. Reinnervation, however, remained regionally heterogeneous, and a complete restoration was not found until 15 years after HTX.
authors: Nuklearmedizinische Klinik und Poliklinik der Technischen Universität München, Germany. frank.bengel@lrz.tu-muenchen.de
authors: F M
authors: FM
authors: Bengel
authors: P
authors: P
authors: Ueberfuhr
authors: S I
authors: SI
authors: Ziegler
authors: S
authors: S
authors: Nekolla
authors: B
authors: B
authors: Reichart
authors: M
authors: M
authors: Schwaiger
mesh_terms: D000328:Adult; D004809:Ephedrine / Q000031:analogs & derivatives; D005260:Female; D005500:Follow-Up Studies; D006329:Heart Conduction System / Q000503:physiopathology*; D016027:Heart Transplantation; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D009416:Nerve Regeneration / Q000502:physiology*; D009638:Norepinephrine / Q000378:metabolism; D011184:Postoperative Period; D013564:Sympathetic Nervous System / Q000503:physiopathology*; D014055:Tomography, Emission-Computed
chemical_list: C065363:3-hydroxyephedrine; D004809:Ephedrine; D009638:Norepinephrine