A nomenclature system for labeling cyclic peptide fragments.
A nomenclature system for labeling fragment ions of cyclic peptides is proposed. A fragment ion is labeled with a four-part descriptor for the general formula xnJZ, where x is the designation for the ion (e.g., lower case a or b, as are used for peptide fragments) and n is the number of amino acid residues in the ion. A b ion is the usual acylium ion or isomeric equivalent consisting of n amino-acid residues, and this ion may lose carbon monoxide to form an a ion. The subscripts J and Z are the one-letter (upper-case) codes for the two amino-acid residues connecting the backbone amide or ester bond, J-Z, that can be viewed as broken to form the decomposing linear ion. The symbol J is for the N-terminal amino-acid residue, and Z is that for the C-terminal amino-acid residue that result from the bond cleavage. The nomenclature system is applicable to a wide range of cyclic peptides, including depsipeptides, cyclic peptides containing modified or unusual amino acids, cyclic peptides bearing a linear peptide moiety, and cyclic peptides that are introduced into the gas phase as metal-ion cationized species.
Ngoka
L C
LC
Department of Chemistry, Washington University, St. Louis, Missouri 63130, USA.
Gross
M L
ML
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D013058:Mass Spectrometry; D010455:Peptides / Q000737:chemistry* / Q000145:classification*; D009626:Terminology as Topic
D010455:Peptides