Dose response studies: how do we make them conclusive?
In this paper we discuss how to make meaningful use of a dose response study. It is argued that concepts like the minimal effective dose are not clinically meaningful and that the purpose of a dose response study should be to identify the drug potency in relation to a known active control. We also discuss various ways of carrying out the analysis.
Källén
A
A
Astra Draco AB, Lund, Sweden.
Larsson
P
P
D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation / Q000706:statistics & numerical data* / Q000639:trends; D006801:Humans; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D010600:Pharmacology / Q000706:statistics & numerical data* / Q000639:trends
D004364:Pharmaceutical Preparations