title: Chemomechanical removal of dental caries in deciduous teeth: further studies in vitro.
abstract: OBJECTIVE
  To further investigate the efficacy of N-monochloro-DL-2-aminobutyrate (NMAB) and NMAB containing 2 M urea (NMAB-urea) as chemomechanical caries removal reagents in deciduous teeth using standardised lesions and limited applicator pressure.
  
  
  METHODS
  In vitro.
  
  
  METHODS
  Carious dentine was removed from standardised lesions in deciduous teeth using NMAB, NMAB-urea or isotonic saline (control); 50 lesions were studied with each reagent. The surface of the dentine remaining in cavities where complete caries removal was achieved was examined by light and scanning electron microscopy.
  
  
  RESULTS
  NMAB-urea (but not NMAB) gave significantly improved caries removal compared with saline. The dentine surfaces remaining after complete caries removal were irregular and approximately one third were bacterially contaminated.
  
  
  CONCLUSIONS
  The improved efficacy of NMAB by the addition of urea has been confirmed. Toxicity studies are still necessary prior to clinical use of this reagent.
authors: University of Hong Kong, Prince Philip Dental Hospital, Hong Kong.
authors: H K
authors: HK
authors: Yip
authors: A G
authors: AG
authors: Stevenson
authors: J A
authors: JA
authors: Beeley
mesh_terms: D000613:Aminobutyrates / Q000008:administration & dosage / Q000627:therapeutic use*; D003731:Dental Caries / Q000382:microbiology / Q000473:pathology / Q000628:therapy*; D003737:Dental Cavity Preparation / Q000295:instrumentation / Q000379:methods*; D003804:Dentin / Q000187:drug effects / Q000382:microbiology / Q000648:ultrastructure; D006801:Humans; D007552:Isotonic Solutions / Q000627:therapeutic use; D008855:Microscopy, Electron, Scanning; D012965:Sodium Chloride / Q000627:therapeutic use; D014094:Tooth, Deciduous / Q000187:drug effects / Q000382:microbiology / Q000648:ultrastructure; D014508:Urea / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D000613:Aminobutyrates; D007552:Isotonic Solutions; D012965:Sodium Chloride; C018172:GK 101E; D014508:Urea