Effect of L-lactic acid on the absorption of calcium in gastrectomized rats.
The effect of dietary L-lactic acid (LA), (0.5, 1.0, or 2.5 g/100 g of diet) on the absorption of calcium in gastrectomized rats was evaluated for 28 d. Calcium phosphate was used as a source of calcium. The apparent calcium absorption ratio and the calcium contents of the femur and tibia in gastrectomized rats fed the control diet were significantly less than those in sham-operated rats. In the gastrectomized rats, the apparent calcium absorption ratio and the calcium contents of bone in the rats fed the lower doses of LA diets (LA 0.5 or 1.0 g/100 g of diet) were not affected; however, the apparent calcium absorption ratio and the calcium contents of bone in the rats fed the highest doses of LA diet (LA 2.5 g/100 g of diet) were greater than those in gastrectomized rats fed the control diet. Dietary LA (2.5 g/100 g of diet) also enhanced the phosphorus absorption and bone phosphorus content in the gastrectomized rats. We speculated that the highest dose of dietary LA might be associated with the dissolving of a water-insoluble form of calcium salt in the diet, thereby facilitating the calcium absorption and resulting in increased bone calcium content in gastrectomized rats.
Chonan
O
O
Yakult Central Institute for Microbiological Research, Tokyo, Japan.
Takahashi
R
R
Yasui
H
H
Watanuki
M
M
D000818:Animals; D001835:Body Weight; D002118:Calcium / Q000032:analysis / Q000378:metabolism*; D002130:Calcium Phosphates / Q000008:administration & dosage; D004435:Eating; D005269:Femur / Q000737:chemistry; D005743:Gastrectomy; D007408:Intestinal Absorption / Q000187:drug effects*; D019344:Lactic Acid / Q000494:pharmacology*; D008297:Male; D010758:Phosphorus / Q000032:analysis / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013977:Tibia / Q000737:chemistry
D002130:Calcium Phosphates; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; D010758:Phosphorus; D019344:Lactic Acid; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous; D002118:Calcium