Identification of connexins in human oral mucosa and therapeutic effect of irsogladine maleate on aphthous stomatitis.
We identified connexins 26 and 32 in human oral mucosa. The presence of the connexins indicates the presence of gap junctions in this tissue. However, immunofluorescence study found no significant differences in the expression of the connexins between patients with aphthons stomatitis and controls. Irsogladine maleate, which reinforces gap junctional intercellular communication in vitro, was effective for the treatment of transient and relapsing aphthous stomatitis, as well as symptomatic and drug-induced aphthous stomatitis. It was also useful for prevention of episodes of relapsing aphthous stomatitis, with daily administration preverting recurrence of stomatitis for more than 4 years one patient. These findings suggest that irsogladine maleate accelerates the wound healing process in oral mucosa by reinforcing gap junctional intercellular communication among oral mucosal cells; and that it is useful for the treatment and prevention of aphthous stomatitis.
Hara
A
A
Department of Internal Medicine, National Health Insurance Organization Minamitama Hospital, Hachioji, Tokyo, Japan.
Murata
T
T
Uemura
R
R
Miura
T
T
Fukui
K
K
Matsukawa
H
H
Kasiwagi
K
K
Ito
T
T
Yoshioka
M
M
Hibi
T
T
D000328:Adult; D000368:Aged; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D002450:Cell Communication; D017630:Connexins / Q000378:metabolism*; D005260:Female; D005455:Fluorescent Antibody Technique; D005500:Follow-Up Studies; D017629:Gap Junctions / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D055502:Secondary Prevention; D013281:Stomatitis, Aphthous / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D014227:Triazines / Q000627:therapeutic use*
D000897:Anti-Ulcer Agents; D017630:Connexins; D014227:Triazines; C041836:irsogladine