Tremor and seizures associated with chronic manganese intoxication.
Tremor and seizures developed in a 2-year-old girl receiving total parenteral nutrition. T1-weighted images on MRI revealed areas of hyperintensity in the basal ganglia, brainstem and cerebellum. Blood manganese was elevated. The symptoms and MRI abnormalities disappeared after withdrawal of manganese administration. The recommendation of daily parenteral manganese intake was discussed.
Komaki
H
H
Department of Child Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.
Maisawa
S
S
Sugai
K
K
Kobayashi
Y
Y
Hashimoto
T
T
D001921:Brain / Q000473:pathology; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008345:Manganese / Q000008:administration & dosage / Q000097:blood; D020149:Manganese Poisoning; D010289:Parenteral Nutrition, Total; D012640:Seizures / Q000139:chemically induced* / Q000175:diagnosis; D014202:Tremor / Q000139:chemically induced* / Q000175:diagnosis
D008345:Manganese