title: Modulatory potential of Spirulina fusiformis on carcinogen metabolizing enzymes in Swiss albino mice.
abstract: The modulatory potential of Spirulina fusiformis was observed on the hepatic and extrahepatic carcinogen metabolizing enzymes in Swiss albino mice at a dose of 800 mg/kg b.w. given orally. A significant reduction in the hepatic cytochrome P-450 content was observed in the group treated with Spirulina in comparison with the control group. The hepatic glutathione S-transferase activity was induced significantly by Spirulina treatment. There was no change in the extrahepatic glutathione S-transferase activity after the animals were fed with Spirulina.
authors: Department of Zoology, University of Rajasthan, Jaipur, India.
authors: A
authors: A
authors: Mittal
authors: P V
authors: PV
authors: Kumar
authors: S
authors: S
authors: Banerjee
authors: A R
authors: AR
authors: Rao
authors: A
authors: A
authors: Kumar
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000494:pharmacology*; D000458:Cyanobacteria; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects*; D005260:Female; D005982:Glutathione Transferase / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008113:Liver Neoplasms / Q000201:enzymology / Q000517:prevention & control*; D051379:Mice; D053545:Spirulina
chemical_list: D016588:Anticarcinogenic Agents; D001426:Bacterial Proteins; D003577:Cytochrome P-450 Enzyme System; D005982:Glutathione Transferase