[The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, liposomes with L-DOPA and "empty" liposomes on the phospholipid composition of the murine liver].
The effect on the liver phospholipid composition of 1-methyl-4-phenyl -1,2,3,6-tetrahydropyridine (MPTP) and liposomes containing L-DOPA and those devoid of it was studied in experiments on C57B1/6 mice. The content of separate phospholipid fractions was expressed in percentage of lipid phosphorus, in nmol lipid phosphorus per 1 mg tissue, and in nmol lipid phosphorus per 1 mg protein. It was found that the content of phosphatidylinositide and phosphatidylethanolamine changed under the effect of MPTP. Injection of liposomes stabilized the level of these phospholipids. The concentration of phosphatidylethanolamine was not restored in animals injected liposomes devoid of L-DOPA. The main changes occurring under the effect of liposomes took place in the sphyngomyelin and phosphatidylcholine fractions.
Podgornyĭ
G N
GN
Research Center, Tver State Medical Academy, Russia.
Namestnikova
I V
IV
Sliusar'
N N
NN
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000494:pharmacology*; D000818:Animals; D002855:Chromatography, Thin Layer; D015259:Dopamine Agents / Q000494:pharmacology*; D004337:Drug Carriers; D007980:Levodopa / Q000494:pharmacology*; D008081:Liposomes / Q000494:pharmacology*; D008099:Liver / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010743:Phospholipids / Q000032:analysis / Q000378:metabolism*; D013997:Time Factors
D015259:Dopamine Agents; D004337:Drug Carriers; D008081:Liposomes; D010743:Phospholipids; D007980:Levodopa; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine