[The immunomodulating action of aminoglycoside antibiotics via different administration technics].
It was shown that intramuscular administration of aminoglycosides such as gentamicin and amikacin had an immunosuppressive action in healthy animals. Administration of the antibiotics entrapped in erythrocyte shades increased the immune response. The immunostimulating effect was higher when the aminoglycosides entrapped in allogenic erythrocytes were administered. After the routine administration of the antibiotics they were detected in the blood and urine within the first hours after the administration. After administration of the antibiotics entrapped in erythrocyte shades their detection was later in time. When the aminoglycosides entrapped in allogenic erythrocytes were administered they were not detected in the biological fluids.
Siplivaia
L E
LE
Kursk State Medical University.
Shetsova
E M
EM
Lazarev
A I
AI
Prokopenko
L G
LG
D000276:Adjuvants, Immunologic / Q000008:administration & dosage* / Q000032:analysis / Q000493:pharmacokinetics; D000583:Amikacin / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000032:analysis / Q000493:pharmacokinetics; D000921:Antibody-Producing Cells / Q000187:drug effects; D004337:Drug Carriers; D004910:Erythrocyte Membrane; D005839:Gentamicins / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D051381:Rats; D017208:Rats, Wistar; D012397:Rosette Formation; D013997:Time Factors
D000276:Adjuvants, Immunologic; D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D005839:Gentamicins; D000583:Amikacin