title: Proteomics: quantitative and physical mapping of cellular proteins.
abstract: Genome sequencing provides a wealth of information on predicted gene products (mostly proteins), but the majority of these have no known function. Two-dimensional gel electrophoresis and mass spectrometry have, coupled with searches in protein and EST databases, transformed the protein-identification process. The proteome is the expressed protein complement of a genome and proteomics is functional genomics at the protein level. Proteomics can be divided into expression proteomics, the study of global changes in protein expression, and cell-map proteomics, the systematic study of protein-protein interactions through the isolation of protein complexes.
authors: Biomolecular Structure Unit, Glaxo Wellcome Research and Development, Stevenage, UK. wpb0799@glaxowellcome.co.uk
authors: W P
authors: WP
authors: Blackstock
authors: M P
authors: MP
authors: Weir
mesh_terms: D001709:Biotechnology / Q000639:trends*; D016678:Genome; D013058:Mass Spectrometry / Q000639:trends*; D010449:Peptide Mapping / Q000639:trends*; D011506:Proteins / Q000032:analysis / Q000235:genetics / Q000302:isolation & purification
chemical_list: D011506:Proteins