Modulatory potential of Spirulina fusiformis on carcinogen metabolizing enzymes in Swiss albino mice.
The modulatory potential of Spirulina fusiformis was observed on the hepatic and extrahepatic carcinogen metabolizing enzymes in Swiss albino mice at a dose of 800 mg/kg b.w. given orally. A significant reduction in the hepatic cytochrome P-450 content was observed in the group treated with Spirulina in comparison with the control group. The hepatic glutathione S-transferase activity was induced significantly by Spirulina treatment. There was no change in the extrahepatic glutathione S-transferase activity after the animals were fed with Spirulina.
Mittal
A
A
Department of Zoology, University of Rajasthan, Jaipur, India.
Kumar
P V
PV
Banerjee
S
S
Rao
A R
AR
Kumar
A
A
D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000494:pharmacology*; D000458:Cyanobacteria; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects*; D005260:Female; D005982:Glutathione Transferase / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008113:Liver Neoplasms / Q000201:enzymology / Q000517:prevention & control*; D051379:Mice; D053545:Spirulina
D016588:Anticarcinogenic Agents; D001426:Bacterial Proteins; D003577:Cytochrome P-450 Enzyme System; D005982:Glutathione Transferase