title: Lipid-lowering medication and risk of cancer.
abstract: Low or declining levels of serum cholesterol have been associated with increased mortality from cancer. We conducted a population-based cohort study of 1882 patients from one Danish county who received lipid-lowering drugs between January 1, 1991 and December 31, 1994. During the follow-up period of up to 4 years, 41 cancers were observed among users of lipid-lowering drugs, with 42.9 expected, to yield an age- and sex-standardized incidence ratio of 1.0 (95% confidence interval, 0.7-1.3). Although limited by small numbers and short follow-up period, examination by site of cancer and type of drug provided no evidence of an association. Further research is needed, however, with longer follow-up to assess more fully any potential cancer risk with these medications.
authors: Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen.
authors: J H
authors: JH
authors: Olsen
authors: C
authors: C
authors: Johansen
authors: H T
authors: HT
authors: Sørensen
authors: J K
authors: JK
authors: McLaughlin
authors: L
authors: L
authors: Mellemkjaer
authors: F H
authors: FH
authors: Steffensen
authors: J F
authors: JF
authors: Fraumeni
mesh_terms: D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D000960:Hypolipidemic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D012306:Risk
chemical_list: D000960:Hypolipidemic Agents