[Delta-opiate receptors and heart resistance to arrhythmogenic factors].
Stimulation of peripheral delta-opioid receptors exerted no effect on arrhythmias, whereas that central delta 1- and delta 2-receptor activation decrease the heart susceptibility to arrhythmogenic action of epinephrine. Pre-treatment with the delta-opioid receptor antagonist ICI 174 prevented the antiarrhythmic effect of the central delta-receptors stimulation. The findings suggest that the heart decreased vulnerability to epinephrine-induced arrhythmias following the central delta-receptors stimulation is mediated by an enhanced vagal activity.
Maslov
L N
LN
Institute of Cardiology, Tomsk, Russia.
Ugdyzhekova
D S
DS
Krylatov
A V
AV
Lishmanov
Iu B
IuB
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000503:physiopathology*; D001921:Brain / Q000378:metabolism; D004837:Epinephrine / Q000633:toxicity; D008297:Male; D009294:Narcotics / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017465:Receptors, Opioid, delta / Q000819:agonists; D017450:Receptors, Opioid, mu / Q000819:agonists
D009294:Narcotics; D017465:Receptors, Opioid, delta; D017450:Receptors, Opioid, mu; D004837:Epinephrine