Clinical hypothyroidism associated with trimethoprim-sulfadiazine administration in a dog.
Treatment of a 9-year-old spayed female mixed-breed dog with trimethoprim-sulfadiazine for a prolonged period resulted in clinical signs of hypothyroidism, and results of thyroid gland function tests were indistinguishable from those associated with endogenous hypothyroidism. Drug-induced hypothyroidism was diagnosed on the basis of history, normal thyroid uptake of sodium pertechnetate, and complete recovery of thyroid gland function after administration of trimethoprim-sulfadiazine was discontinued.
Gookin
J L
JL
Department of Companion Animal and Special Species Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA.
Trepanier
L A
LA
Bunch
S E
SE
D000818:Animals; D000892:Anti-Infective Agents, Urinary / Q000009:adverse effects*; D004283:Dog Diseases / Q000139:chemically induced*; D004285:Dogs; D004338:Drug Combinations; D005260:Female; D007037:Hypothyroidism / Q000139:chemically induced / Q000662:veterinary*; D013411:Sulfadiazine / Q000009:adverse effects*; D014295:Trimethoprim / Q000009:adverse effects*; D000096926:Benzenesulfonamides
D000892:Anti-Infective Agents, Urinary; D004338:Drug Combinations; D013411:Sulfadiazine; D014295:Trimethoprim; C024873:sulfadiazine, trimethoprim drug combination; D000096926:Benzenesulfonamides