title: Five-year 224-patient prospective histological study of clinical applications using a synthetic bone alloplast.
abstract: Clinical and histologic evaluations of a synthetic bone were performed in 224 patients in a well monitored environment. This material (Bioplant HTR, Bioplant Inc., South Norwalk, CT) was used to obliterate cysts, treat periodontal defects, correct jawbone contours and deficiencies, and gain sufficient support for the placement of dental implants in maxillary subantral augmentation. Implants were positioned either at the time of the synthetic bone graft or after the new supporting tissue was formed. Evidence of new bone formation between the synthetic granules and host tissue was observed during histological examinations. After the material was placed, tissue that could strengthen and augment the inferior wall of the maxillary sinus formed in 3 months. This was observed both clinically and radiographically. After 8 to 12 months, this tissue provided sufficient hard tissue support for the placement of dental implants. This clinical study reconfirmed the applicability of a synthetic bone for bone replacement and augmentation in oral and maxillofacial surgery. No complications caused by infection, inflammation, or rejection of the implanted graft material were observed.
authors: Department of Periodontology, University of Medicine and Dentistry of New Jersey, Newark, USA.
authors: A G
authors: AG
authors: Haris
authors: G
authors: G
authors: Szabo
authors: A
authors: A
authors: Ashman
authors: T
authors: T
authors: Divinyi
authors: Z
authors: Z
authors: Suba
authors: K
authors: K
authors: Martonffy
mesh_terms: D000328:Adult; D000540:Alveolar Ridge Augmentation / Q000379:methods*; D001861:Bone Regeneration; D018786:Bone Substitutes; D016025:Bone Transplantation / Q000379:methods*; D003758:Dental Implantation, Endosseous / Q000379:methods*; D005260:Female; D006801:Humans; D007568:Jaw / Q000502:physiology; D007570:Jaw Cysts / Q000601:surgery; D008297:Male; D008443:Maxillary Sinus / Q000502:physiology / Q000601:surgery; D008768:Methylmethacrylates; D008875:Middle Aged; D019647:Oral Surgical Procedures / Q000379:methods*; D056948:Orthognathic Surgical Procedures; D011102:Polyhydroxyethyl Methacrylate; D011446:Prospective Studies; D014945:Wound Healing
chemical_list: D018786:Bone Substitutes; D008768:Methylmethacrylates; D011102:Polyhydroxyethyl Methacrylate; C040206:HTR composite