Immunogenetic mechanisms of antibody response to measles vaccine: the role of the HLA genes.
Measles is the most transmissible human disease known to date. In the prevaccine era, virtually every member of each birth cohort was infected with this virus, leading to substantial morbidity and mortality, with millions of deaths on a global scale. At the current time, measles causes an estimated 1 to 1.5 million deaths per year world-wide. Since the advent of live, attenuated measles vaccines measles has been controlled, but not eradicated. Central to the goal of measles eradication are data relating to the influence of immunogenetics on vaccine immunogenicity. In this paper, the results of studies are reviewed executed in my laboratory examining the role of the class I and II HLA genes on the antibody response to measles vaccine.
Poland
G A
GA
Mayo Vaccine Research Group, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA. poland.gregory@mayo.edu
D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters / Q000235:genetics; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D002874:Chromosome Mapping; D005805:Genes, MHC Class I / Q000502:physiology*; D005802:Genes, MHC Class II / Q000502:physiology*; D006684:HLA-DR Antigens / Q000235:genetics; D006801:Humans; D008458:Measles Vaccine / Q000276:immunology*
D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters; D000914:Antibodies, Viral; D006684:HLA-DR Antigens; D008458:Measles Vaccine; C071692:TAP2 protein, human