Genetic polymorphism of platelet glycoprotein IIIa in patients with acute myocardial infarction and acute ischaemic stroke.
BACKGROUND
It has recently been suggested that the Leu33Pro polymorphism of the platelet glycoprotein IIIa affects the risk of coronary thrombosis. Finland is genetically isolated and has an incidence of cardiovascular disease among the highest in the world. Interestingly, the prevalence of ischaemic heart disease also varies in different parts of the country, being highest in eastern Finland.


METHODS
We studied the Leu33Pro polymorphism using polymerase chain reaction in 133 patients with coronary artery disease, 234 patients with cerebrovascular disease and 326 control subjects originating from two areas of Finland.


RESULTS
The frequencies of the Pro33 allele in the patients with acute myocardial infarction and cerebrovascular attack were 13% and 14%, respectively, and did not differ from the controls (13%). Among patients with acute myocardial infarction from the Helsinki area, the family history of premature coronary artery disease was more often positive in carriers of the Pro33 allele than in non-carriers, but after adjustment for multiple comparisons the difference was no longer significant.


CONCLUSIONS
We could not confirm the original observation that the Pro33 allele constitutes an independent risk factor for coronary artery disease. Further studies are needed to clarify whether co-occurrence of Pro33 and some unrecognized inherited factor pose an additional risk of vascular disease.
Kekomäki
S
S
Finnish Red Cross Blood Transfusion Service, Helsinki, Finland.
Hämäläinen
L
L
Kauppinen-Mäkelin
R
R
Palomäki
H
H
Kaste
M
M
Kontula
K
K
D000328:Adult; D000787:Angina Pectoris / Q000235:genetics; D016824:Antigens, Human Platelet / Q000235:genetics*; D002545:Brain Ischemia / Q000235:genetics*; D016009:Chi-Square Distribution; D004198:Disease Susceptibility; D005260:Female; D005387:Finland / Q000453:epidemiology; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012307:Risk Factors; D018709:Statistics, Nonparametric
D016824:Antigens, Human Platelet; D019039:Platelet Glycoprotein GPIIb-IIIa Complex