[A pivotal role of activated hepatic macrophage in the progression of alcoholic liver disease].
Our clinical and experimental research results indicated the possibility that gut-derived endotoxin contributes to the development of alcoholic liver disease. Long-term ethanol consumption resulted in an enhanced secretory function of hepatic macrophage accompanied by an ultrastructural feature of activation. The liver of rats fed on ethanol-diet were found to have an enhanced ability to produce CINC-1 (rat IL-8) after endotoxin injection. This chemokine may contribute to neutrophil recruitment into the liver in alcoholic liver injury. Females exhibited a greater ability to produce CINC-1 than males, and this fact may account for the gender difference in susceptibility to alcohol-related liver disease.
Yamada
S
S
Department of Clinical Pathophysiology, School of Health Sciences, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan.
D000818:Animals; D054360:Chemokine CXCL1; D019743:Chemokines, CXC; D002630:Chemotactic Factors / Q000096:biosynthesis; D004731:Endotoxins / Q000494:pharmacology; D005260:Female; D006133:Growth Substances / Q000096:biosynthesis; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008099:Liver / Q000166:cytology*; D008108:Liver Diseases, Alcoholic / Q000209:etiology* / Q000473:pathology; D008262:Macrophage Activation; D008264:Macrophages / Q000502:physiology*; D008297:Male; D051381:Rats; D012737:Sex Factors
C475829:CXCL1 protein, human; D054360:Chemokine CXCL1; D019743:Chemokines, CXC; D002630:Chemotactic Factors; C513297:Cxcl1 protein, rat; D004731:Endotoxins; D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins