title: Genetic correlation in otosclerosis.
abstract: OBJECTIVE
  The aim of this study was to determine the relationship of HLA typing in patients with otosclerosis.
  
  
  METHODS
  We used a prospective study in which HLA typing of 100 surgically confirmed otosclerosis patients were compared with age and sex matched normal individuals.
  
  
  RESULTS
  HLA-A3, HLA-A9, HLA-A11, and HLA-B13 were found to be significantly higher (P < .05, .01, and .01, respectively). HLA-A9 and HLA-A11 were found to be higher (P < .01) in patients with a positive family history, indicating genetic heterogenicity.
  
  
  CONCLUSIONS
  Higher values of HLA-A9, HLA-11, and HLA-B13 in patients with otosclerosis compared with normal individuals strongly suggests a genetic, HLA-related component.
authors: Department of Otolaryngology and Head & Neck Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors: S K
authors: SK
authors: Singhal
authors: S B
authors: SB
authors: Mann
authors: U
authors: U
authors: Datta
authors: N K
authors: NK
authors: Panda
authors: A K
authors: AK
authors: Gupta
mesh_terms: D000293:Adolescent; D000328:Adult; D000939:Epitopes; D005260:Female; D006680:HLA Antigens / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D008875:Middle Aged; D010040:Otosclerosis / Q000235:genetics*; D011446:Prospective Studies
chemical_list: D000939:Epitopes; D006680:HLA Antigens