The novel sarcomeric protein telethonin exhibits developmental and functional regulation.
We have isolated a cDNA clone from a mouse skeletal muscle library which is preferentially expressed in striated muscle and exhibits a high homology to human telethonin, a sarcomeric protein. The mouse telethonin transcript is developmentally regulated in both cardiac and skeletal muscle in vivo and is down-regulated in response to denervation. In the C2C12 muscle cell-line the mouse telethonin transcript exhibited a pattern of accumulation similar to that observed for a contractile protein and suggests a role in myofibrillar assembly.
Mason
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Molecular Physiology Unit, Department of Veterinary Basic Sciences, The Royal Veterinary College, NWI 0TU, London,
Bayol
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Loughna
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D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D003001:Cloning, Molecular; D064211:Connectin; D015536:Down-Regulation; D018507:Gene Expression Regulation, Developmental; D006614:Hindlimb; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D018485:Muscle Fibers, Skeletal / Q000378:metabolism; D009124:Muscle Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000294:innervation / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009928:Organ Specificity; D010641:Phenotype; D010802:Phylogeny; D012333:RNA, Messenger / Q000032:analysis / Q000378:metabolism; D012519:Sarcoplasmic Reticulum / Q000378:metabolism*; D012584:Sciatic Nerve / Q000601:surgery; D017386:Sequence Homology, Amino Acid
D064211:Connectin; D009124:Muscle Proteins; D012333:RNA, Messenger; C577292:TCAP protein, human; C577294:Tcap protein, mouse