Multiple G-protein-coupled pathways inhibit N-type Ca channels of neurons.
Muscarinic receptors depress Ca2+ currents in superior cervical ganglion neurons by two signaling pathways. One is sensitive to pertussis toxin and acts rapidly by a membrane-delimited pathway on the channels. The other is not sensitive to pertussis toxin and acts more slowly through an unknown second messenger. These pathways are shared with several other agonists.
Hille
B
B
Department of Physiology and Biophysics, University of Washington, Seattle 98195, USA.
Beech
D J
DJ
Bernheim
L
L
Mathie
A
A
Shapiro
M S
MS
Wollmuth
L P
LP
D000470:Alkaloids / Q000494:pharmacology; D000818:Animals; D015220:Calcium Channels / Q000378:metabolism*; D005663:Furans; D019204:GTP-Binding Proteins / Q000378:metabolism*; D018721:Muscarinic Agonists / Q000494:pharmacology; D018727:Muscarinic Antagonists / Q000494:pharmacology; D009281:Naphthalenes; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D010095:Oxotremorine / Q000031:analogs & derivatives / Q000494:pharmacology; D018408:Patch-Clamp Techniques; D037342:Pertussis Toxin; D010880:Piperidines; D010890:Pirenzepine / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000378:metabolism*; D017783:Superior Cervical Ganglion / Q000187:drug effects / Q000378:metabolism*; D010566:Virulence Factors, Bordetella / Q000494:pharmacology
D000470:Alkaloids; D015220:Calcium Channels; D005663:Furans; D018721:Muscarinic Agonists; D018727:Muscarinic Antagonists; D009281:Naphthalenes; D010880:Piperidines; D011976:Receptors, Muscarinic; D010566:Virulence Factors, Bordetella; D010890:Pirenzepine; D010095:Oxotremorine; C042743:oxotremorine M; D037342:Pertussis Toxin; D019204:GTP-Binding Proteins; C048172:himbacine