title: Critical closing pressure in cerebrovascular circulation.
abstract: OBJECTIVE
  Cerebral critical closing pressure (CCP) has been defined as an arterial pressure threshold below which arterial vessels collapse. Hypothetically this is equal to intracranial pressure (ICP) plus the contribution from the active tone of cerebral arterial smooth muscle. The correlation of CCP with ICP, cerebral autoregulation, and other clinical and haemodynamic modalities in patients with head injury was evaluated.
  
  
  METHODS
  intracranial pressure, arterial blood pressure (ABP) and middle cerebral artery blood flow velocity were recorded daily in ventilated patients. Waveforms were processed to calculate CCP, the transcranial Doppler-derived cerebral autoregulation index (Mx), mean arterial pressure (ABP), intracranial pressure (ICP), and cerebral perfusion pressure (CPP).
  
  
  RESULTS
  Critical closing pressure reflected the time related changes in ICP during plateau and B waves. Overall correlation between CCP and ICP was mild but significant (R=0.41; p<0.0002). The mean difference between ABP and CCP correlated with CPP (R=0.57, 95% confidence interval (95% CI) for prediction 25 mm Hg). The difference between CCP and ICP, described previously as proportional to arterial wall tension, correlated with the index of cerebral autoregulation Mx (p<0.0002) and CPP (p<0.0001). However, by contrast with the Mx index, CCP-ICP was not significantly correlated with outcome after head injury.
  
  
  CONCLUSIONS
  Critical closing pressure, although sensitive to variations in ICP and CPP, cannot be used as an accurate estimator of these modalities with acceptable confidence intervals. The difference CCP-ICP significantly correlates with cerebral autoregulation, but it lacks the power to predict outcome after head injury.
authors: Wolfson Brain Imaging Centre, MRC Cambridge Centre for Brain Repair and Academic Neurosurgical Unit, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK. MC141@MEDSCHL.CAM.AC.UK
authors: M
authors: M
authors: Czosnyka
authors: P
authors: P
authors: Smielewski
authors: S
authors: S
authors: Piechnik
authors: P G
authors: PG
authors: Al-Rawi
authors: P J
authors: PJ
authors: Kirkpatrick
authors: B F
authors: BF
authors: Matta
authors: J D
authors: JD
authors: Pickard
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001794:Blood Pressure / Q000502:physiology*; D001930:Brain Injuries / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D013997:Time Factors