title: Brain activation in PTSD in response to trauma-related stimuli.
abstract: BACKGROUND
  Repetitive recall of traumatic memories and chronic intermittent hyperarousal are characteristic of posttraumatic stress disorder (PTSD). Hyperarousal and memory dysfunction implicates "limbic" brain regions, including the amygdaloid complex, hippocampal formation, and limbic cortex, such as the orbitofrontal and anterior cingulate areas. To investigate the neurobiologic role of these brain regions in PTSD, we measured regional cerebral blood flow in PTSD with single photon emission computerized tomography (SPECT) during a symptom provocation paradigm.
  
  
  METHODS
  Fourteen Vietnam veterans with PTSD, 11 combat control subjects, and 14 normal control subjects were studied with [99mTc]HMPAO in two sessions 48 hours apart: one session after exposure to white noise and the other following exposure to combat sounds. Skin conductance, heart rate, and subjective experience were recorded at the time of the studies.
  
  
  RESULTS
  Activation for all three groups occurred in the anterior cingulate/middle prefrontal gyrus. Activation in the region of the left amygdala/nucleus accumbens was found in PTSD patients only. Deactivation was found in all three groups in the left retrosplenial region.
  
  
  CONCLUSIONS
  These findings implicate regions of the "limbic" brain, which may mediate the response to aversive stimuli in healthy individuals and in patients suffering from PTSD.
authors: Psychiatry Service, Ann Arbor VAMC, MI, USA.
authors: I
authors: I
authors: Liberzon
authors: S F
authors: SF
authors: Taylor
authors: R
authors: R
authors: Amdur
authors: T D
authors: TD
authors: Jung
authors: K R
authors: KR
authors: Chamberlain
authors: S
authors: S
authors: Minoshima
authors: R A
authors: RA
authors: Koeppe
authors: L M
authors: LM
authors: Fig
mesh_terms: D001143:Arousal / Q000502:physiology*; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000503:physiopathology; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003130:Combat Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology; D003463:Cues; D005712:Galvanic Skin Response / Q000502:physiology; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D013315:Stress, Psychological / Q000523:psychology; D017741:Survivors / Q000523:psychology; D015899:Tomography, Emission-Computed, Single-Photon; D014481:United States; D014728:Veterans / Q000523:psychology; D014744:Vietnam