Ability of human plasma to protect against ionising radiation is inversely correlated with age.
Human blood plasma from persons 30-80 years of age have been measured by a total antioxidant assay using a highly fluorescent molecule, beta-phycoerythrin (BPE), as the target for radiation-generated free radicals. The plasma samples showed an inverse relationship between radioprotective ability and donor age. The results are consistent with data showing that protein from older subjects provides less protection against oxidative stress than that from middle-aged subjects.
Lenton
K J
KJ
Radiation Biology and Health Physics Branch, AECL, Chalk River Laboratories, Ontario, Canada. klenton@courrier.usherb.ca
Greenstock
C L
CL
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood* / Q000528:radiation effects; D000975:Antioxidants / Q000378:metabolism / Q000528:radiation effects; D001798:Blood Proteins / Q000378:metabolism / Q000528:radiation effects; D016166:Free Radical Scavengers / Q000097:blood; D006801:Humans; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology; D010799:Phycoerythrin / Q000378:metabolism; D010949:Plasma / Q000502:physiology* / Q000528:radiation effects; D011832:Radiation Injuries / Q000097:blood / Q000517:prevention & control; D011835:Radiation Protection; D011839:Radiation, Ionizing; D011837:Radiation-Protective Agents
D000975:Antioxidants; D001798:Blood Proteins; D016166:Free Radical Scavengers; D011837:Radiation-Protective Agents; D010799:Phycoerythrin