Bioavailability of ginkgolides and bilobalide from extracts of ginkgo biloba using GC/MS.
The bioavailability of ginkgolides A, B and bilobalide was studied in rats after single oral administration of 30, 55 and 100 mg/kg Ginkgo extract EGb 761. The plasma levels of the terpene lactones were measured by a specific GC/MS method. The pharmacokinetics of the mentioned substances were found to be dose-linear. For the lowest dose maximum concentrations were 68, 40 and 159 ng/ml and half-lives 1.7, 2.0 and 2.2 h for ginkgolide A, B and bilobalide, respectively. Clearance values ranged from 24.2 to 37.6 ml/min/kg.
Biber
A
A
Koch
E
E
D000818:Animals; D001682:Biological Availability; D003517:Cyclopentanes / Q000302:isolation & purification / Q000493:pharmacokinetics*; D004224:Diterpenes; D005663:Furans / Q000302:isolation & purification / Q000493:pharmacokinetics*; D008401:Gas Chromatography-Mass Spectrometry; D020441:Ginkgo biloba / Q000737:chemistry*; D046934:Ginkgolides; D006207:Half-Life; D007783:Lactones / Q000302:isolation & purification / Q000493:pharmacokinetics*; D008297:Male; D010936:Plant Extracts / Q000737:chemistry; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D015203:Reproducibility of Results
D003517:Cyclopentanes; D004224:Diterpenes; D005663:Furans; D046934:Ginkgolides; D007783:Lactones; D010936:Plant Extracts; C045856:ginkgolide B; C073710:bilobalide