title: 'Naïve' and 'memory' CD4+ T-cells and T-cell receptor (TCR) V beta repertoire dynamics are independent of the levels of viremia following HIV seroconversion.
abstract: The progression of 'naive' and 'memory' T-cells and the T-cell receptor Vbeta (TCR Vbeta) repertoire dynamics within the peripheral CD4+ T-cell compartment were studied in individuals following HIV seroconversion. Profound TCR Vbeta repertoire perturbations were observed within the CD4+ T-cell pool in treatment-naive patients regardless of their levels of viremia during the first 6-8 months after seroconversion. The ratio of 'naive' to 'memory' CD4+ T-cells as well as the TCR Vbeta repertoire dynamics did not appear to correlate with absolute numbers of CD4 T-cells.
authors: Department of Immunology, ICSM, Chelsea and Westminster Hospital, London, UK.
authors: D J
authors: DJ
authors: King
authors: P
authors: P
authors: Amjadi
authors: R
authors: R
authors: Tilling
authors: S
authors: S
authors: Kinloch-de-Loes
authors: C
authors: C
authors: Loveday
authors: M A
authors: MA
authors: Johnson
authors: G
authors: G
authors: Janossy
authors: A
authors: A
authors: Tarragona
authors: F
authors: F
authors: Gotch
authors: E L
authors: EL
authors: Larsson-Sciard
mesh_terms: D000293:Adolescent; D000328:Adult; D016516:CD4-CD8 Ratio; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D006679:HIV Seropositivity / Q000276:immunology* / Q000821:virology*; D006801:Humans; D007135:Immunoglobulin Variable Region / Q000276:immunology*; D007156:Immunologic Memory / Q000276:immunology*; D008297:Male; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology*; D014766:Viremia / Q000276:immunology
chemical_list: D007135:Immunoglobulin Variable Region; D016693:Receptors, Antigen, T-Cell, alpha-beta