title: [Isotopic study with double phase 99mTc-sestamibi in the localization of parathyroid gland lesions].
abstract: BACKGROUND
  The use of preoperative imaging in patients with hyperparathyroidism remains controversial. The aim of this study is to assess the usefulness of the double-phase 99mTc-sestamibi scintigraphy in the diagnosis of abnormal parathyroid glands in patients with primary hyperparathyroidism.
  
  
  METHODS
  We studied 60 patients presenting with primary hyperparathyroidism who were referred to surgery; four of them had been unsuccessfully operated. 99mTc-sestamibi scintigraphy were performed in all patients previously to surgery. Scintigraphic technique: planar imaging of the neck and thorax was done in the anterior view at 15 and 150 min postinjection of 740 MBq (20 mCi) of 99mTc-sestamibi.
  
  
  RESULTS
  Surgery found 57 adenomas (2.59 [SD, 5.84] g; range 0.160-40), 6 hyperplastic glands (0.34 [SD, 0.26] g) and one carcinoma 8.2 g. The 99mTc-sestamibi was able to localize correctly 60 out of 64 lesions (55/57 adenomas, 4/6 hyperplastic glands and 1/1 carcinoma) (global sensitivity of 94%, adenomas sensitivity of 96%, positive predictive value of 97% and specificity of 98%). Isotopic imaging detected the abnormal tissue in all patients who had undergone unsuccessful previous surgery. PTH (4 [SD, 1.51] pmol/l) and calcium postoperative serum levels (2.13 [SD, 0.22] mmol/l) showed curation of all patients.
  
  
  CONCLUSIONS
  Double phase parathyroid scintigraphy with 99mTc-sestamibi is the method of choice to localize abnormal parathyroid glands.
authors: Servicio de Medicina Nuclear, Hospital de la Santa Creu i Sant Pau, Bercelona.
authors: L
authors: L
authors: Bernà
authors: J
authors: J
authors: Piera
authors: J
authors: J
authors: Rodríguez-Espinosa
authors: A
authors: A
authors: Caixàs
authors: M
authors: M
authors: Puig-Domingo
authors: J
authors: J
authors: Farrerons
authors: M
authors: M
authors: Galofré
authors: F
authors: F
authors: Rousaud
authors: X
authors: X
authors: Matías-Guiu
authors: M
authors: M
authors: Estorch
authors: I
authors: I
authors: Carrió
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010279:Parathyroid Diseases / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi
chemical_list: D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi