The expression of palmitoyl-protein thioesterase is developmentally regulated in neural tissues but not in nonneural tissues.
Mutations in a palmitoyl-protein thioesterase (PPT) gene cause infantile neuronal ceroid lipofuscinosis (INCL). INCL is characterized by an extreme and selective neuronal loss in cerebral cortex and retina. Using reverse transcriptase PCR we show that PPT expression is developmentally regulated in rat brain and eyes but not in spleen. The changes in the expression coincide with developmental events in the brain. These data indicate that PPT has an important role in the development of the CNS.
Suopanki
J
J
Institute of Biomedicine, Department of Medical Chemistry, University of Helsinki, Finland. jaana.suopanki@helsinki.fi
Tyynelä
J
J
Baumann
M
M
Haltia
M
M
D000199:Actins / Q000378:metabolism; D000367:Age Factors; D000818:Animals; D001921:Brain / Q000378:metabolism; D002490:Central Nervous System / Q000196:embryology / Q000254:growth & development*; D002531:Cerebellum / Q000378:metabolism; D005123:Eye / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D051381:Rats; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013154:Spleen / Q000378:metabolism; D013869:Thiolester Hydrolases / Q000378:metabolism*; D013997:Time Factors; D014018:Tissue Distribution
D000199:Actins; D013869:Thiolester Hydrolases; C095299:palmitoyl-protein thioesterase