New vaccines against tuberculosis. The status of current research.
The increasing realization that the current vaccine for tuberculosis, bacille Calmette-Guérin (BCG), is of varying effectiveness, and is less protective in adults than in children, has prompted new research for a replacement. New research has resulted in innovative approaches, including the use of sub-unit vaccines, auxotropic vaccines, DNA vaccines, and recombinant vaccines, among others. This article reviews these approaches and test results in animal models, and discusses their potential for use in humans.
Orme
I M
IM
Department of Microbiology, Colorado State University, Fort Collins, USA.
D000328:Adult; D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology*; D002648:Child; D002986:Clinical Trials as Topic; D006801:Humans; D009161:Mycobacterium / Q000276:immunology*; D012106:Research; D014376:Tuberculosis / Q000517:prevention & control*
D001428:Bacterial Vaccines