title: Octa- and nonaprenylhydroquinone sulfates, inhibitors of alpha1,3-fucosyltransferase VII, from an Australian marine sponge Sarcotragus sp.
abstract: Alpha1,3-fucosyltransferase (Fuc TVII) is a key enzyme in the biosynthesis of selectin ligands. We have isolated two inhibitors of Fuc TVII from a marine sponge Sarcotragus sp. They were characterized as octa- and nonaprenylhydroquinone sulfates on the basis of spectral data. These compounds inhibited Fuc-TVII with IC50 values of 3.9 and 2.4 microg/mL, respectively.
authors: Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan.
authors: T
authors: T
authors: Wakimoto
authors: A
authors: A
authors: Maruyama
authors: S
authors: S
authors: Matsunaga
authors: N
authors: N
authors: Fusetani
authors: K
authors: K
authors: Shinoda
authors: P T
authors: PT
authors: Murphy
mesh_terms: D000818:Animals; D001315:Australia; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005647:Fucosyltransferases / Q000037:antagonists & inhibitors*; D011161:Porifera / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D013729:Terpenes; C119120:nonaprenylhydroquinone sulfate; C119119:octaprenylhydroquinone sulfate; D005647:Fucosyltransferases; C031692:galactoside 3-fucosyltransferase