Squamometry: an evaluation method for a barrier protectant (tannic acid).
Squamometry for evaluating skin barrier substances is described. Forearms of 8 volunteers were dosed with 0, 0.25, 0.5, and 1% sodium lauryl sulfate (SLS) in distilled water (semi-open method) for 24 h, to skin pretreated with distilled water and 5% tannic acid, a model barrier protectant. Squamometric evaluation indicated the skin damage increased with SLS concentration in a dose-dependent manner, and that tannic acid reduced the damage (p<0.01). The results suggest that squamometry may be a useful method for determining efficacy of skin barrier substances.
Shimizu
T
T
Life Science Research Center, Lion Corporation, Odawara, Kanagawa, Japan.
Maibach
H I
HI
D000368:Aged; D001252:Astringents / Q000494:pharmacology*; D003124:Colorimetry / Q000379:methods; D017449:Dermatitis, Allergic Contact / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D047348:Hydrolyzable Tannins / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D012867:Skin / Q000187:drug effects / Q000473:pathology; D012967:Sodium Dodecyl Sulfate / Q000009:adverse effects; D013501:Surface-Active Agents / Q000009:adverse effects
D001252:Astringents; D047348:Hydrolyzable Tannins; D013501:Surface-Active Agents; D012967:Sodium Dodecyl Sulfate