title: Diaschisis in chronic viral encephalitis with Koshevnikov syndrome.
abstract: The authors report a 61-year-old man with chronic viral encephalitis and Koshevnikov syndrome occurring 42 months after initial symptom of right hemiparesis. Serial computed tomography of the brain showed changes in the attenuation of the left temporal lobe lesion over time. Magnetic resonance images of the brain showed enlargement of left temporoparietooccipital lobes with cortical gyral enhancement on T1-weighted images following intravenous administration of gadolinium-DTPA. 99mTc-HMPAO single-photon emission computerized tomography showed increased radioactivity and hyperperfusion in the left temporoparietal region with paradoxically decreased local tissue perfusion at the contralateral right hemisphere. Follow-up magnetic resonance images of the brain 4 years later showed atrophy of bilateral cerebral hemispheres. We postulate that a "transcallosal diaschisis" with subsequent degeneration is a possible mechanism. A brain biopsy from the left temporal lobe lesion showed pictures compatible with viral encephalitis probably herpes simplex encephalitis.
authors: Section of Neurology, Cathay General Hospital, Taipei, Taiwan, ROC.
authors: P
authors: P
authors: Thajeb
authors: K M
authors: KM
authors: Huang
authors: C C
authors: CC
authors: Shih
mesh_terms: D001284:Atrophy; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000821:virology*; D002560:Cerebrovascular Circulation; D002908:Chronic Disease; D003287:Contrast Media; D003337:Corpus Callosum / Q000821:virology*; D018792:Encephalitis, Viral / Q000175:diagnosis*; D017036:Epilepsia Partialis Continua / Q000821:virology*; D005500:Follow-Up Studies; D019786:Gadolinium DTPA; D006561:Herpes Simplex / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009778:Occipital Lobe / Q000821:virology; D010296:Parietal Lobe / Q000098:blood supply / Q000821:virology; D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime; D013702:Temporal Lobe / Q000098:blood supply / Q000473:pathology / Q000821:virology; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime; D019786:Gadolinium DTPA