Simultaneous monitoring of endothelin-1 and vasopressin plasma levels in migraine.
Vasopressin levels in plasma rise during migraine attacks. Vasopressin also induces endothelin-1 synthesis in endothelial cells, suggesting a role as a mediator of elevated plasma endothelin-1 in migraine. To explore a possible relationship between endothelin-1 and vasopressin in migraine, plasma concentrations of both peptides were monitored simultaneously throughout an attack and during two migraine-free intervals (control) in 20 patients. Endothelin-1 was elevated 6 h after the onset of an attack (3.3 +/- 0.3 pg/ml vs 2.7 +/- 0.2 pg/ml during migraine-free intervals; p = 0.12) whereas vasopressin was increased over control levels (2.8 +/- 0.3 pg/ml) by 3 h (3.6 +/- 0.4 pg/ml; p < 0.05) and remained elevated at 6 h (3.9 +/- 0.5 pg/ml; p < 0.01). These data suggest that vasopressin may act as a peripheral mediator of increased plasma endothelin-1 in migraine.
Hasselblatt
M
M
Department of Neurology, Georg-August-University, and Max-Planck-Institute for Experimental Medicine, Göttingen, Germany.
Köhler
J
J
Volles
E
E
Ehrenreich
H
H
D000328:Adult; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000097:blood*; D008991:Monitoring, Physiologic; D009994:Osmolar Concentration; D014667:Vasopressins / Q000097:blood*
D019332:Endothelin-1; D014667:Vasopressins