title: [The blood-simulating properties of a recombinant colony-stimulating factor and glycyram during cytostatic myelosuppression].
abstract: The hemostimulating activity of the drug glycyrram and the recombinant granulocytic-macrophagic colony-stimulating factor (CSF) was compared on models of myelosuppression induced by injection of an alkylating agent cyclophospane (CF) or the antimetabolite 5-fluorouracil (5-FU). It was found that glycerram stimulated hematopoiesis more effectively after 5-FU injection but to a lesser extent (in relation to CSF) in CF injection.
authors: Institute of Pharmacology, Tomsk Research Center, Russian Academy of Medical Sciences, Russia.
authors: A M
authors: AM
authors: Dygaĭ
authors: V V
authors: VV
authors: Zhdanov
authors: V I
authors: VI
authors: Masycheva
authors: M Iu
authors: MIu
authors: Minakova
authors: V P
authors: VP
authors: Romanov
authors: N M
authors: NM
authors: Pustoshilova
authors: E V
authors: EV
authors: Simanina
authors: V I
authors: VI
authors: Agafonov
authors: E D
authors: ED
authors: Gol'dberg
mesh_terms: D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology*; D018906:Antineoplastic Agents, Alkylating / Q000494:pharmacology; D001853:Bone Marrow / Q000187:drug effects*; D003114:Colony-Forming Units Assay / Q000706:statistics & numerical data; D003520:Cyclophosphamide / Q000494:pharmacology; D003864:Depression, Chemical; D005472:Fluorouracil / Q000494:pharmacology; D006034:Glycyrrhetinic Acid / Q000494:pharmacology*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology*; D006410:Hematopoiesis / Q000187:drug effects*; D051379:Mice; D008808:Mice, Inbred CBA; D011994:Recombinant Proteins; D013268:Stimulation, Chemical; D013997:Time Factors
chemical_list: D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D018906:Antineoplastic Agents, Alkylating; D011994:Recombinant Proteins; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D003520:Cyclophosphamide; D006034:Glycyrrhetinic Acid; D005472:Fluorouracil