Gli genes and limb development.
During development of the limb Shh plays a key role as a mediator of zone of polarizing activity (ZPA). However, the molecular mechanisms by which Shh directs anterior/posterior patterning in the limb remain unknown. Members of the Gli gene family encode zinc-finger transcription factors and represent likely candidates for being regulators of Shh target genes. In this review we would like to summarize the current knowledge on expression and function of Gli genes in limb development.
Theil
T
T
Institut für Molekularbiologie, Medizinische Hochschule Hannover, OE 5250, D-30623 Hannover, Germany.
Kaesler
S
S
Grotewold
L
L
Böse
J
J
Rüther
U
U
D000818:Animals; D002490:Central Nervous System / Q000196:embryology; D005121:Extremities / Q000196:embryology*; D018507:Gene Expression Regulation, Developmental; D053823:Hedgehog Proteins; D006801:Humans; D005810:Multigene Family; D009154:Mutation; D015513:Oncogene Proteins / Q000235:genetics* / Q000502:physiology; D017689:Polydactyly / Q000235:genetics; D011506:Proteins / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction; D015534:Trans-Activators; D014157:Transcription Factors / Q000235:genetics* / Q000502:physiology; D000071676:Zinc Finger Protein GLI1; D016335:Zinc Fingers
D053823:Hedgehog Proteins; D015513:Oncogene Proteins; D011506:Proteins; C509239:SHH protein, human; D015534:Trans-Activators; D014157:Transcription Factors; D000071676:Zinc Finger Protein GLI1