Octa- and nonaprenylhydroquinone sulfates, inhibitors of alpha1,3-fucosyltransferase VII, from an Australian marine sponge Sarcotragus sp.
Alpha1,3-fucosyltransferase (Fuc TVII) is a key enzyme in the biosynthesis of selectin ligands. We have isolated two inhibitors of Fuc TVII from a marine sponge Sarcotragus sp. They were characterized as octa- and nonaprenylhydroquinone sulfates on the basis of spectral data. These compounds inhibited Fuc-TVII with IC50 values of 3.9 and 2.4 microg/mL, respectively.
Wakimoto
T
T
Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan.
Maruyama
A
A
Matsunaga
S
S
Fusetani
N
N
Shinoda
K
K
Murphy
P T
PT
D000818:Animals; D001315:Australia; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005647:Fucosyltransferases / Q000037:antagonists & inhibitors*; D011161:Porifera / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D004791:Enzyme Inhibitors; D013729:Terpenes; C119120:nonaprenylhydroquinone sulfate; C119119:octaprenylhydroquinone sulfate; D005647:Fucosyltransferases; C031692:galactoside 3-fucosyltransferase