[The effect of erythromycin on immunity in immunodeficiency].
The effect of 12.5 and 25 mg/kg doses of erythromycin on the immunity of intact mice and in cyclophosphan- and azathioprine-induced immunodeficiency was studied. Erythromycin has no effect on the number of antibody-forming cells in the spleen of intact and immunocompromised with cyclophosphan animals. It increases their number against the background of azathioprine. Immunosuppression may change the character of the effect of erythromycin on delayed hypersensitivity. Erythromycin stimulates phagocyte activity in intact animals and in immunosuppression.
Sakaeva
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DD
Department of Pharmacology, Bashkir State Medical University, Ufa, Russia.
Lazareva
D N
DN
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000917:Antibody Formation / Q000187:drug effects; D001379:Azathioprine; D003520:Cyclophosphamide; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004917:Erythromycin / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D007111:Immunity, Cellular / Q000187:drug effects; D007153:Immunologic Deficiency Syndromes / Q000139:chemically induced* / Q000276:immunology; D007166:Immunosuppressive Agents; D008297:Male; D051379:Mice; D011512:Proteus Infections / Q000188:drug therapy / Q000276:immunology / Q000401:mortality; D011513:Proteus mirabilis; D013997:Time Factors
D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents; D004917:Erythromycin; D003520:Cyclophosphamide; D001379:Azathioprine