'Naïve' and 'memory' CD4+ T-cells and T-cell receptor (TCR) V beta repertoire dynamics are independent of the levels of viremia following HIV seroconversion.
The progression of 'naive' and 'memory' T-cells and the T-cell receptor Vbeta (TCR Vbeta) repertoire dynamics within the peripheral CD4+ T-cell compartment were studied in individuals following HIV seroconversion. Profound TCR Vbeta repertoire perturbations were observed within the CD4+ T-cell pool in treatment-naive patients regardless of their levels of viremia during the first 6-8 months after seroconversion. The ratio of 'naive' to 'memory' CD4+ T-cells as well as the TCR Vbeta repertoire dynamics did not appear to correlate with absolute numbers of CD4 T-cells.
King
D J
DJ
Department of Immunology, ICSM, Chelsea and Westminster Hospital, London, UK.
Amjadi
P
P
Tilling
R
R
Kinloch-de-Loes
S
S
Loveday
C
C
Johnson
M A
MA
Janossy
G
G
Tarragona
A
A
Gotch
F
F
Larsson-Sciard
E L
EL
D000293:Adolescent; D000328:Adult; D016516:CD4-CD8 Ratio; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D006679:HIV Seropositivity / Q000276:immunology* / Q000821:virology*; D006801:Humans; D007135:Immunoglobulin Variable Region / Q000276:immunology*; D007156:Immunologic Memory / Q000276:immunology*; D008297:Male; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology*; D014766:Viremia / Q000276:immunology
D007135:Immunoglobulin Variable Region; D016693:Receptors, Antigen, T-Cell, alpha-beta