title: Correlation of tumor suppressor P53 RNA expression with human immunodeficiency virus disease in rapid and slow progressors.
abstract: OBJECTIVE
  To determine the relation between P53 tumor suppressor RNA expression and human immunodeficiency virus (HIV) disease progression.
  
  
  METHODS
  A quantitative assay of P53 RNA expression was used to analyze a cohort of HIV-negative persons. The assay was then used in longitudinal and cross-sectional studies of HIV slow and rapid progressors.
  
  
  RESULTS
  We demonstrate first that P53 expression in peripheral blood mononuclear cells from HIV-1-seronegative persons is minimal. Longitudinal studies in a small cohort of HIV-1-infected slow and rapid progressors reveal that rapid progressors seem to have greater P53 RNA expression over time. This was validated in a cohort of 26 HIV-1-infected persons in whom the expression of P53 RNA was significantly greater in persons with rapid progression of HIV-1 disease.
  
  
  CONCLUSIONS
  These data suggest that P53 RNA expression may play a role in the pathogenesis of HIV-1 disease, though the mechanism of this interaction remains unknown.
authors: Department of Medicine, University of Maryland, Baltimore, USA.
authors: R J
authors: RJ
authors: McLinden
authors: B
authors: B
authors: Lewis
authors: N L
authors: NL
authors: Michael
authors: R R
authors: RR
authors: Redfield
authors: D L
authors: DL
authors: Birx
authors: J H
authors: JH
authors: Kim
mesh_terms: D000818:Animals; D018791:CD4 Lymphocyte Count; D016466:CHO Cells; D002453:Cell Cycle; D006224:Cricetinae; D018450:Disease Progression; D015870:Gene Expression; D016147:Genes, Tumor Suppressor; D015658:HIV Infections / Q000097:blood / Q000235:genetics* / Q000276:immunology / Q000821:virology; D018023:HIV Seronegativity; D015497:HIV-1 / Q000502:physiology; D006801:Humans; D012333:RNA, Messenger / Q000032:analysis; D016159:Tumor Suppressor Protein p53 / Q000032:analysis / Q000097:blood / Q000235:genetics*; D019562:Viral Load
chemical_list: D012333:RNA, Messenger; D016159:Tumor Suppressor Protein p53