Dimer formation by tRNAs.
Available data on formation of dimers and other oligomers by "mature" tRNAs and the transcripts of their genes show that the dimers may be formed in vitro during the purification of individual tRNAs as well as on heating and subsequent cooling of tRNA preparations. The functional activity of dimers varies for different tRNAs. Structural analysis of tRNAs that are able or unable to form dimers suggests the importance of the hairpin melting temperature for dimer formation. Pathways of dimer formation and specific structural features of tRNA dimers are discussed.
Kholod
N S
NS
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 117984, Russia. xolod@imb.imb.ac.ru
D000604:Amino Acyl-tRNA Synthetases / Q000378:metabolism; D001483:Base Sequence; D019281:Dimerization; D004355:Drug Stability; D008274:Magnesium / Q000737:chemistry; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D012329:RNA, Bacterial / Q000737:chemistry; D012331:RNA, Fungal / Q000737:chemistry; D012343:RNA, Transfer / Q000737:chemistry* / Q000235:genetics; D012344:RNA, Transfer, Ala / Q000737:chemistry; D012365:RNA, Transfer, Tyr / Q000737:chemistry; D013696:Temperature
D012329:RNA, Bacterial; D012331:RNA, Fungal; D012344:RNA, Transfer, Ala; D012365:RNA, Transfer, Tyr; D012343:RNA, Transfer; D000604:Amino Acyl-tRNA Synthetases; D008274:Magnesium