[Experimental model of subfebrile condition of central origin].
Central model of subfebrility was experimentally developed using administration of fresh homologous blood from an unanesthetised donor into the rat brain lateral ventricle. Rectal temperature significantly increased by the end of the 1st day of the administration. Duration of the hyperthermic response was about 8 days. The body temperature rise varied from 0.45 to 0.7 degrees C. The central subfebrility had no initial fenrile phase. An increased level of glucose in the blood serum during central subfebrility suggests an altered activity of the sympathetic nervous system to be one of the causes of the subfebrility development.
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Institute of Physiology of the Belorussian Nat. Acad. Sci., Minsk, Belorussia.
D000818:Animals; D001769:Blood; D001831:Body Temperature; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D004195:Disease Models, Animal; D005335:Fever of Unknown Origin / Q000503:physiopathology*; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D013238:Stereotaxic Techniques