New cycloalkylpyrazoles as potential cyclooxygenase inhibitors.
In this study some cycloalkyl-3-(N-substituted carbamoyl)-1-phenylpyrazoles have been synthesized in order to screen their capability to inhibit human cyclooxygenase. The synthetic pathway is based on the well known property of nitrilimines to undergo 1,3-dipolar cycloaddition reactions. The structures of all the synthesized compounds have been elucidated by means of both analytical and spectroscopic methods.
Cardia
M C
MC
Corda
L
L
Fadda
A M
AM
Maccioni
A M
AM
Maccioni
E
E
Plumitallo
A
A
D016861:Cyclooxygenase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D016861:Cyclooxygenase Inhibitors; D011720:Pyrazoles