Isolated clinic hypertension is not an innocent phenomenon: effect on the carotid artery structure.
This study examines the common carotid intimal-medial wall thickness (CCA-IMT) in untreated patients with elevated clinic blood pressure (BP) but normal ambulatory BP (isolated clinic hypertension, n = 22), in comparison with a group with elevated clinic and ambulatory BP (hypertensives, n = 41) and a group with normal clinic and ambulatory BP (normotensives, n = 17) readings. The three groups did not differ in age, male/female ratio, lipid profile, glucose tolerance test, or smoking habits. No difference existed in CCA-IMT values between the groups with hypertension (0.67 +/- 0.18 mm) and isolated clinic hypertension (0.68 +/- 0.14 mm), but the values in these two groups were significantly higher (one-way ANOVA; F = 8.09, P < .001) than in the group of normotensives (0.50 +/- 0.09 mm). The CCA-IMT did not correlate with clinic systolic or diastolic BP readings or with BP derivatives of 24-h ambulatory monitoring. Mean 24-h BP in the isolated clinic hypertensives did not differ from that in the normotensives, whereas both were lower than in the hypertensives. We conclude that changes in the CCA-IMT occuring in subjects with isolated clinic hypertension are equal to the changes in sustained hypertension, indicating that isolated clinic hypertension may not be a benign condition.
Zakopoulos
N
N
Athens University, Department of Clinical Therapeutics, Greece.
Papamichael
C
C
Papaconstantinou
H
H
Dubbins
P A
PA
Burrell
C J
CJ
Lekakis
J
J
Stamatelopoulos
S
S
Moulopoulos
S
S
D000328:Adult; D000704:Analysis of Variance; D018660:Blood Pressure Monitoring, Ambulatory; D017536:Carotid Artery, Common / Q000473:pathology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000473:pathology / Q000503:physiopathology*; D008055:Lipids / Q000097:blood; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D012907:Smoking; D017539:Tunica Intima / Q000473:pathology
D008055:Lipids