title: Increases in 4-hydroxynonenal and hexanal in bone marrow of rats subjected to total body X-ray irradiation: association with antioxidant vitamins.
abstract: Radiation-induced lipid peroxidation and its association with antioxidant vitamins in the bone marrow (BM), of rats subjected to total body irradiation (TBI) of X-rays at a dose of 3 Gy was investigated. The concentration of vitamin C in the BM decreased at 4 h, and reached about 2% of the control level at 24 h after irradiation. The concentration of vitamin E in the BM also decreased to 43% at 24 h. Corresponding to the decrease in vitamin E concentration, the concentration of 4-hydroxynonenal (HNE) in the BM increased 2.5-fold at 24 h. Similarly, increases in the concentrations of hexanal and thiobarbituric acid-reactive substances (TBA-RS) were detected in the BM. In the plasma, these parameters of lipid peroxidation were unchanged up to 48 h, but were increased at 96 h after irradiation. Four days of vitamin E administration to rats (p.o. 460 mg/kg body weight) prior to the 3 Gy X-irradiation increased the vitamin E concentration in the BM to 1.3-fold the control level, but did not attenuate the increases in HNE and hexanal in the BM. The slight accumulation of vitamin E in the BM as a result of the vitamin E treatment may be partly related to this lack of vitamin E effect.
authors: Division of Applied Food Research, The National Institute of Health and Nutrition, Tokyo, Japan.
authors: K
authors: K
authors: Umegaki
authors: M
authors: M
authors: Sano
authors: K
authors: K
authors: Suzuki
authors: I
authors: I
authors: Tomita
authors: T
authors: T
authors: Esashi
mesh_terms: D000447:Aldehydes / Q000032:analysis*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001853:Bone Marrow / Q000737:chemistry* / Q000528:radiation effects*; D015853:Cysteine Proteinase Inhibitors / Q000032:analysis*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014810:Vitamin E / Q000494:pharmacology; D014815:Vitamins / Q000494:pharmacology; D014916:Whole-Body Irradiation
chemical_list: D000447:Aldehydes; D000975:Antioxidants; D015853:Cysteine Proteinase Inhibitors; D014815:Vitamins; D014810:Vitamin E; C010463:n-hexanal; C027576:4-hydroxy-2-nonenal