Regulating the onset of mitosis.
In eukaryotes, G2/M progression is mediated by activation of mitosis promoting factor (MPF). To ensure faithful chromosome segregation, the activity of key mitotic inducers and inhibitors are coupled with chromosome replication, spindle pole duplication, morphogenesis, and DNA damage. Evidence gathered in the past two years has underscored the importance of positioning MPF and its regulators in the proper place at the proper time to ensure orderly progression through the G2/M transition. Altering the spatial organization of G2/M regulators also contributes to prevention of mitosis following DNA damage.
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Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. ryoma.ohi@mcmail.vanderbilt.edu
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D000818:Animals; D001692:Biological Transport; D016203:CDC2 Protein Kinase / Q000502:physiology*; D002451:Cell Compartmentation; D002453:Cell Cycle / Q000502:physiology; D019926:Cyclin B / Q000502:physiology*; D004249:DNA Damage; D029721:Drosophila Proteins; D005057:Eukaryotic Cells / Q000166:cytology / Q000378:metabolism; D005656:Fungal Proteins / Q000502:physiology; D005658:Fungi / Q000166:cytology / Q000502:physiology; D016195:G2 Phase; D006801:Humans; D016200:Maturation-Promoting Factor / Q000502:physiology*; D008938:Mitosis / Q000502:physiology*; D008954:Models, Biological; D010766:Phosphorylation; D020033:Protein Isoforms / Q000502:physiology; D011499:Protein Processing, Post-Translational / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000502:physiology; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D008941:Spindle Apparatus / Q000502:physiology; D014714:Vertebrates / Q000502:physiology; D014982:Xenopus laevis / Q000502:physiology
C503698:CycB protein, Drosophila; D019926:Cyclin B; D029721:Drosophila Proteins; D005656:Fungal Proteins; D020033:Protein Isoforms; D011505:Protein-Tyrosine Kinases; D017346:Protein Serine-Threonine Kinases; D016203:CDC2 Protein Kinase; D016200:Maturation-Promoting Factor