[A case of cerebral juvenile pilocytic astrocytoma: observation of the development of the tumor].
A case with cerebral juvenile pilocytic astrocytoma (JPA) was reported. The patient was 33-month-old boy, who developed headache and loss of activity on December, 1994. Although he was indicated macrocephaly at the age of just 1 year, CT scan showed no abnormality at that time. On admission, MRI revealed multiple large cysts with an enhanced mural nodule in the left frontal lobe. The tumor was totally removed, and histologically diagnosed as JPA, because of alternating two types of structures of loose knit tissue composed of satellite astrocytes and compact tissue consisting of highly fibrillate cells. MIB-1 percent positivity was almost negative. We summarized and discussed the clinicopathological and proliferating characteristics of the cerebral JPA. These considerations suggested that the tumor already existed at the age of 1 year and developed during these 20 months, according to the theory that the growth rate of JPAs is programmed to slow down as the patient grows.
Sugiyama
K
K
Department of Neurosurgery, Hiroshima University School of Medicine, Japan.
Kurisu
K
K
Arita
K
K
Ohba
S
S
Mizoue
T
T
Harada
K
K
Sadatomo
T
T
Yoshioka
H
H
Hama
S
S
Uozumi
T
T
D001254:Astrocytoma / Q000473:pathology* / Q000601:surgery; D001932:Brain Neoplasms / Q000473:pathology* / Q000601:surgery; D002455:Cell Division; D002675:Child, Preschool; D005500:Follow-Up Studies; D005625:Frontal Lobe; D006801:Humans; D008297:Male