Maternal and fetal plasma levels of markers of bone metabolism in gestational diabetic pregnancies.
The aim of this study is to determine whether gestational diabetes has any effect on maternal and fetal bone metabolism. We collected maternal and umbilical cord blood samples from 19 women with gestational diabetes and 19 controls at the time of delivery. The plasma levels of carboxy terminal pro-peptide of type I pro-collagen (PICP) and cross-linked carboxyterminal telopeptide of type I collagen (ICTP) were used to monitor the rate of bone formation and degradation respectively. There is a significant correlation between the 1 hour postprandial blood glucose and the maternal levels of ICTP (r = 0.560, P = 0.004), but there was no significant difference in maternal or fetal levels of PICP and ICTP between the study and control groups (P = 0.411 maternal PICP, P = 0.241 maternal ICTP, P = 0.365 fetal PICP and P = 0.781 fetal ICTP). In the gestational diabetes group, there was a significant correlation between maternal and fetal ICTP (r = 0.694, P = 0.001), but there was no correlation between maternal and fetal levels of PICP (r = 0.334, P = 0.175). Although the maternal levels of ICTP is related to the 1 hour postprandial blood glucose level, gestational diabetes does not affect the maternal or umbilical cord levels of the serum markers of bone metabolism.
Ogueh
O
O
Academic Obstetrics and Gynaecology, Imperial College School of Medicine at Chelsea and Westminster Hospital, London, UK.
Khastgir
G
G
Studd
J
J
Jones
J
J
Alaghband-Zadeh
J
J
Johnson
M R
MR
D015415:Biomarkers / Q000097:blood*; D001842:Bone and Bones / Q000196:embryology* / Q000378:metabolism*; D003094:Collagen / Q000097:blood; D024042:Collagen Type I; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005333:Fetus / Q000378:metabolism; D005502:Food; D005865:Gestational Age; D006801:Humans; D010446:Peptide Fragments / Q000097:blood; D010455:Peptides / Q000097:blood; D011247:Pregnancy; D011347:Procollagen / Q000097:blood
D015415:Biomarkers; D024042:Collagen Type I; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; C052929:collagen type I trimeric cross-linked peptide; C042813:procollagen type I carboxy terminal peptide; D003094:Collagen