Effects of 3alpha- and 3beta-galactosylated alpha-galactosylceramides on the immune system.
We compared effects of alpha-galactosylceramide (alpha-GalCer) and its 3alpha- or 3beta-galactosylated derivatives on the proliferation of murine spleen cells. The 3alpha-galactosylated alpha-GalCer showed stronger proliferative response than the parental alpha-GalCer, but the 3beta-galactosylated alpha-GalCer possessed weaker activity than the alpha-GalCer. In addition, alpha-Gal-3-Cer did not show immunostimulatory activity.
Sakai
T
T
Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Gunma, Japan.
Morita
M
M
Matsunaga
N
N
Akimoto
K
K
Yokoyama
T
T
Iijima
H
H
Koezuka
Y
Y
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D002455:Cell Division / Q000187:drug effects / Q000276:immunology; D002518:Ceramides / Q000138:chemical synthesis / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005699:Galactosylceramides / Q000138:chemical synthesis / Q000494:pharmacology; D007107:Immune System / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000166:cytology / Q000187:drug effects* / Q000276:immunology
C119060:AGL 529; C119061:AGL 533; D000276:Adjuvants, Immunologic; D002518:Ceramides; D005699:Galactosylceramides