title: Carotid endarterectomy in patients with significant renal dysfunction.
abstract: OBJECTIVE
  Recent reports suggest that carotid endarterectomy (CEA) should not be performed in patients with end-stage renal disease (ESRD) because of an unacceptable rate of perioperative stroke and other morbidity. Because these conclusions were based on a small number of patients, we reviewed the perioperative and long-term outcome of patients with ESRD and chronic renal insufficiency (CRI) who underwent CEA at our institution.
  
  
  METHODS
  The 1081 patients who had a CEA between 1990 and 1997 were cross-referenced with those patients in whom renal insufficiency had been diagnosed. These charts were reviewed for patient demographics and perioperative and long-term outcome. Patients undergoing CEA during a 1-year period (1993) served as controls.
  
  
  RESULTS
  Fifty-one CEAs were performed in 44 patients with CRI (32 in 27 patients) and ESRD (19 in 17 patients). In the CRI+ESRD group, 66.7% were symptomatic, and 70.7% of the control group were symptomatic. Six operations (11.8%) in the CRI+ESRD group were redo endarterectomies. There were no perioperative strokes in the CRI+ESRD group, but one patient died 29 days postoperatively because of a myocardial infarction, for a combined stroke-mortality rate of 2.0%. The control group had a 2.6% combined stroke-mortality rate. Long-term survival analysis revealed a 4-year survival rate of 12% for patients with ESRD and 54% for patients with CRI, compared with 72% for controls (P <.05).
  
  
  CONCLUSIONS
  CEA can be performed safely in patients with ESRD or CRI, with perioperative stroke and death rates equivalent to that of patients without renal dysfunction. However, the benefit of long-term stroke prevention in the asymptomatic patient with ESRD is in question because of the high 4-year mortality rate of this patient population.
authors: Ochsner Clinic and Foundation, New Orleans, LA 70121, USA.
authors: W C
authors: WC
authors: Sternbergh
authors: C L
authors: CL
authors: Garrard
authors: M D
authors: MD
authors: Gonze
authors: J D
authors: JD
authors: Manord
authors: J C
authors: JC
authors: Bowen
authors: S R
authors: SR
authors: Money
mesh_terms: D000368:Aged; D016893:Carotid Stenosis / Q000150:complications* / Q000401:mortality / Q000601:surgery; D003404:Creatinine / Q000097:blood; D016894:Endarterectomy, Carotid; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications* / Q000401:mortality; D008297:Male; D016019:Survival Analysis
chemical_list: D003404:Creatinine