Effects of cadmium on lipid peroxides and superoxide dismutase in hepatic, renal and testicular tissue of rats.
Daily i.p. administration of 0.5 mg cadmium (Cd)/kg body weight to rats for 3 mo enhanced lipid peroxidation and inhibited superoxide dismutase (SOD) activity in liver, kidney and testes. Accumulation of Cd and SOD inhibition was maximum in liver followed by kidney and testes, indicating a direct effect of Cd on SOD activity. This suggests a role of free radicals in causing cellular damage with long-term exposure to cadmium.
Patra
R C
RC
Division of Medicine, Indian Veterinary Research Institute, Izatnagar, India.
Swarup
D
D
Senapati
S K
SK
D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D066298:In Vitro Techniques; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism*; D013737:Testis / Q000187:drug effects* / Q000378:metabolism; D013997:Time Factors
D008054:Lipid Peroxides; D002104:Cadmium; D013482:Superoxide Dismutase