title: Examining the immune response in sentinel lymph nodes of mice and men.
abstract: Recently, it was recognized that an immune response develops along one of two major pathways. One leads to a destructive immune response (type 1), while the alternative leads to a nondestructive immune response (type 2). Our studies in animal models suggest that therapeutic vaccines induce a tumor-specific type 1 immune response while ineffective vaccines induce a type 2 response. These results have led us to examine the immune response in sentinel lymph nodes draining tumor vaccines of patients entered onto clinical trials for melanoma, breast and renal cell cancer.
authors: Robert W. Franz Cancer Research Center, Earle A. Chiles Research Institute, Providence Poartland Medical Center, Portland, OR 97213, USA.
authors: Y
authors: Y
authors: Chu
authors: H M
authors: HM
authors: Hu
authors: H
authors: H
authors: Winter
authors: W J
authors: WJ
authors: Wood
authors: T
authors: T
authors: Doran
authors: D
authors: D
authors: Lashley
authors: J
authors: J
authors: Bashey
authors: J
authors: J
authors: Schuster
authors: J
authors: J
authors: Wood
authors: B A
authors: BA
authors: Lowe
authors: J T
authors: JT
authors: Vetto
authors: A D
authors: AD
authors: Weinberg
authors: R
authors: R
authors: Puri
authors: J W
authors: JW
authors: Smith
authors: W J
authors: WJ
authors: Urba
authors: B A
authors: BA
authors: Fox
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000276:immunology* / Q000628:therapy; D019496:Cancer Vaccines; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000276:immunology* / Q000628:therapy; D008198:Lymph Nodes / Q000276:immunology*; D008207:Lymphatic Metastasis / Q000276:immunology*; D008297:Male; D008545:Melanoma / Q000276:immunology* / Q000628:therapy; D051379:Mice
chemical_list: D019496:Cancer Vaccines