title: Is gliadin mispresented to the immune system in coeliac disease? A hypothesis.
abstract: The primary pathogenic trigger in coeliac disease (CD) is still unknown. We present the hypothesis that in CD the enterocytes could metabolize gliadin through an immunogenic pathway instead of a tolerogenic one. The result of this abnormal presentation of gliadin to the immune system would be the activation of lamina propria T cells, followed by the onset of enteropathy.
authors: Gastroentrology Unit (GKT), Rayne Institute, St Thomas' Hospital, London, UK.
authors: F
authors: F
authors: Biagi
authors: K P
authors: KP
authors: Zimmer
authors: P D
authors: PD
authors: Thomas
authors: H J
authors: HJ
authors: Ellis
authors: P J
authors: PJ
authors: Ciclitira
mesh_terms: D000938:Antigen-Presenting Cells / Q000276:immunology*; D015703:Antigens, CD / Q000276:immunology; D002446:Celiac Disease / Q000276:immunology*; D005805:Genes, MHC Class I / Q000276:immunology; D005903:Gliadin / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007107:Immune System / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D011503:Transglutaminases / Q000276:immunology
chemical_list: D015703:Antigens, CD; D005903:Gliadin; D011503:Transglutaminases