Coupling of transcription and translation in Dictyostelium discoideum nuclei.
The nuclei of Dictyostelium discoideum cells have been found to contain polyribosomes active in protein synthesis. mRNA molecules enter nuclear polyribosomes while they are still being synthesized. "Non sense mediated mRNA decay" occurs in the nucleus, through the interaction of the mRNAs containing a nonsense codon with newly formed nuclear ribosomes, rather than with cytoplasmic ribosomes, as previously generally supposed.
Mangiarotti
G
G
Department of Clinical and Biological Sciences, Ospedale S. Luigi, Orbassano, To, Italy.
D000818:Animals; D002467:Cell Nucleus / Q000235:genetics* / Q000378:metabolism; D018389:Codon, Nonsense; D004023:Dictyostelium / Q000166:cytology / Q000235:genetics* / Q000378:metabolism; D011132:Polyribosomes / Q000235:genetics / Q000378:metabolism; D014176:Protein Biosynthesis; D015800:Protozoan Proteins / Q000096:biosynthesis / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
D018389:Codon, Nonsense; D015800:Protozoan Proteins; D012333:RNA, Messenger