A case of multiple sebaceous epithelioma: analysis of microsatellite instability.
Sebaceous gland tumor is a rare disease that is a sign of Muir-Torre syndrome, an autosomal, dominantly inherited genodermatosis characterized by the presence of at least one sebaceous gland tumor and a minimum of one internal malignancy. Recent studies have indicated that defective DNA mismatch repair occurs in Muir-Torre syndrome. Cutaneous lesions may occur before diagnosis of the internal cancer. We describe a 64-year-old male patient with multiple sebaceous epitheliomas with no evident internal malignancy. Microsatellite instability, determined by examining dinucleotide CA repeats at the microsatellite loci, was observed in DNA from one sebaceous epithelioma but not from the other two sebaceous epitheliomas or from one basal cell epithelioma with sebaceous differentiation, suggesting that this condition is unlikely to be due to germ-line mutation of mismatch repair genes.
Ueda
M
M
Department of Dermatology, Kobe University School of Medicine, Japan.
Wang
Y
Y
Sugimura
H
H
Tamura
S
S
Kondoh
M
M
Ichihashi
M
M
D018266:Adenocarcinoma, Sebaceous / Q000235:genetics / Q000473:pathology*; D000328:Adult; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000473:pathology*; D012626:Sebaceous Gland Neoplasms / Q000235:genetics / Q000473:pathology*; D012867:Skin / Q000473:pathology; D013577:Syndrome