Regulation of amelogenin gene expression.
The X-chromosomal amelogenin gene is expressed at a high level by ameloblast cells within the enamel organ for a short time during tooth development. Therefore, expression is both tooth specific and developmentally regulated. A Y-chromosomal amelogenin gene is also active in human and cow, but has not been detected in mouse. Genes and/or cDNAs have been cloned for mouse, human, cow, rat, pig, opossum, and hamster, and analyses have indicated that coding and upstream regions are conserved across species. Alternative splicing is extensive and produces as many as 9 mRNAs from the 7 exon murine gene, resulting from single and multiple exon skipping and alternate 3' site selection within exon 6. The pattern of alternative splicing varies both between species and during development, which is expected to result in some diversity through varying complements of amelogenin proteins associated with this highly conserved gene.
Gibson
C W
CW
Department of Anatomy and Histology, University of Pennnsylvania School of Dental Medicine, Philadelphia 19104, USA.
D017398:Alternative Splicing / Q000235:genetics; D053523:Amelogenin; D000818:Animals; D001483:Base Sequence; D003746:Dental Enamel Proteins / Q000235:genetics* / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D012045:Regulatory Sequences, Nucleic Acid; D012730:Sex Chromosomes / Q000235:genetics; D013045:Species Specificity; D014070:Tooth / Q000196:embryology / Q000254:growth & development*; D014157:Transcription Factors / Q000235:genetics
D053523:Amelogenin; C507200:Amelx protein, mouse; C507201:Amelx protein, rat; D003746:Dental Enamel Proteins; D014157:Transcription Factors