title: A gustatory cyclic nucleotide-gated channels CNGgust, is expressed in the retina.
abstract: Cyclic nucleotide-gated (CNG) channels are essential proteins that contribute to the intracellular signal transduction of the senses of sight and smell. Recently, we found a novel CNG channel (CNGgust) in rat taste buds, and demonstrated its possible involvement in taste signal transduction. In the present study, we used RT-PCR and immunostaining to prove that this gustatory CNG channel is expressed in the outer segments of rat cone photoreceptor cells. The study strongly suggests that the senses of taste and sight share, at least in part, a common signal transduction pathway.
authors: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, Japan.
authors: T
authors: T
authors: Misaka
authors: Y
authors: Y
authors: Ishimaru
authors: K
authors: K
authors: Iwabuchi
authors: Y
authors: Y
authors: Kusakabe
authors: S
authors: S
authors: Arai
authors: Y
authors: Y
authors: Emori
authors: K
authors: K
authors: Abe
mesh_terms: D000818:Animals; D054815:Cyclic Nucleotide-Gated Cation Channels; D007150:Immunohistochemistry; D015640:Ion Channel Gating / Q000502:physiology*; D007473:Ion Channels / Q000096:biosynthesis* / Q000235:genetics / Q000502:physiology; D008297:Male; D020419:Photoreceptor Cells, Vertebrate / Q000502:physiology; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D012160:Retina / Q000166:cytology / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015398:Signal Transduction / Q000502:physiology; D013649:Taste / Q000502:physiology*
chemical_list: C108144:Cnga3 protein, rat; D054815:Cyclic Nucleotide-Gated Cation Channels; D007473:Ion Channels; D012333:RNA, Messenger