Comparison of the biodistribution in mice of 111indium oxine encapsulated into poly(lactic-co-glycolic)-D,L-85/15 and poly(epsilon caprolactone) nanocapsules.
Poly(lactic-co-glycolic)-D,L-85/15 (PLAGA) nanocapsules and poly(epsilon caprolactone) (PCL) nanocapsules were labeled with a relatively long half-life compound that is usually used in humans; that is, 111In-labelled oxine (111In oxine). This labeling technique led to a high 111In oxine entrapment efficiency and good stability during dialysis against phosphate buffer and phosphate buffered albumin solution. Because of these characteristics, the nanocapsules biodistribution was followed up after intravenous administration for up to 96 h by determining the gamma activity in the tissues after sampling. The administration of the PCL-encapsulated 111In oxine led to a decrease in the blood radioactivity and an increase in the liver radioactivity compared with the solution. This effect was even more pronounced with the PLAGA nanocapsules. Finally, the activity level in other tissues, such as the kidneys, the lungs, and the spleen, appeared to be rather low and only slightly affected by the encapsulation into one or the other polymer.
Marchal-Heussler
L
L
Novartis Pharma, Pharmaceutical Development, Basel, Switzerland.
Thouvenot
P
P
Hoffman
M
M
Maincent
P
P
D000818:Animals; D004339:Drug Compounding; D005079:Excipients; D007205:Indium Radioisotopes / Q000493:pharmacokinetics; D007275:Injections, Intravenous; D007668:Kidney / Q000378:metabolism; D019344:Lactic Acid; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D051379:Mice; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics*; D015125:Oxyquinoline / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D011091:Polyesters; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers; D013154:Spleen / Q000378:metabolism; D014018:Tissue Distribution
D005079:Excipients; D007205:Indium Radioisotopes; D009942:Organometallic Compounds; D011091:Polyesters; D011108:Polymers; C032950:indium oxine; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; C016240:polycaprolactone; D011100:Polyglycolic Acid; D019344:Lactic Acid; D015125:Oxyquinoline