Functional recovery from cortical hemiplegia in the rat: effects of a callosotomy.
The present work aimed at studying the participation of the homologous contralateral zone to a unilateral somatomotor cortex lesion, once the animals had showed a significant functional recovery. We studied recovery of coordinated walking after unilateral motor cortex aspiration in rats. A callosotomy was performed 20 days after the initial lesion, without significant effects. We conclude that after this time period, the intact hemisphere plays no role in the recovery process, suggesting that at this time point recovery does not depend on the integrity of corpus callosal fibers at this rostral-caudal level.
Zepeda
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A
Department of Neurosciences, Institute of Cellular Physiology, Universidad Nacional Autónoma de México, Mexico City. angelica@neuro.mpg.de
Montiel
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T
Brailowsky
S
S
D000818:Animals; D001930:Brain Injuries / Q000473:pathology / Q000503:physiopathology*; D003337:Corpus Callosum / Q000473:pathology / Q000502:physiology*; D007839:Functional Laterality / Q000502:physiology; D006429:Hemiplegia / Q000473:pathology / Q000503:physiopathology*; D001239:Inhalation; D008297:Male; D009044:Motor Cortex / Q000293:injuries* / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D013003:Somatosensory Cortex / Q000293:injuries* / Q000473:pathology / Q000503:physiopathology; D013997:Time Factors; D016138:Walking / Q000502:physiology