A comprehensive protein resource for the study of bladder cancer: http://biobase.dk/cgi-bin/celis.
In our laboratories we are exploring the possibility of using proteome expression profiles of fresh bladder tumors (transitional cell carcinomas, TCCs; squamous cell carcinomas, SCCs) and random biopsies as fingerprints to subclassify histopathological types and as a starting point to search for protein markers that may form the basis for diagnosis, prognosis, and treatment. Ultimately, the goal of these studies is to identify signaling pathways and components that are affected at various stages of bladder cancer progression and that may provide novel leads in drug discovery. Here we present our ongoing efforts to establish comprehensive two-dimensional polyacrylamide gel electrophoresis (2-D PAGE) databases of TCCs and SCCs which are being constructed based on the proteomic and immunohistochemical analysis of hundreds of fresh tumors, random biopsies and cystectomies received shortly after operation (http://biobase.dk/cgi-bin/celis).
Celis
J E
JE
Department of Medical Biochemistry and Danish Centre for Human Genome Research, University of Aarhus, Aarhus C. jec@biokemi.au.dk
Ostergaard
M
M
Rasmussen
H H
HH
Gromov
P
P
Gromova
I
I
Varmark
H
H
Palsdottir
H
H
Magnusson
N
N
Andersen
I
I
Basse
B
B
Lauridsen
J B
JB
Ratz
G
G
Wolf
H
H
Orntoft
T F
TF
Celis
P
P
Celis
A
A
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000737:chemistry*; D002295:Carcinoma, Transitional Cell / Q000737:chemistry*; D016208:Databases, Factual; D006801:Humans; D020407:Internet; D009363:Neoplasm Proteins / Q000032:analysis*; D001749:Urinary Bladder Neoplasms / Q000737:chemistry*
D009363:Neoplasm Proteins