Carcinosarcoma, endometrial intraepithelial carcinoma and endometriosis after tamoxifen therapy in breast cancer.
The fourth case of heterologous mesodermal tumour of the uterine corpus, that developed, years following tamoxifen therapy for breast cancer in a postmenopausal woman with no previous pelvic irradiation, is presented with coincidental endometriosis and endometrial intraepithelial carcinoma. This coincidence after tamoxifen treatment appears to be an indication for the possible carcinogenic potency of tamoxifen.
Friedrich
M
M
Department of Gynecology and Obstetrics, University of Homburg/Saar, Germany.
Villena-Heinsen
C
C
Mink
D
D
Bonkhoff
H
H
Schmidt
W
W
D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology; D002272:Carcinoembryonic Antigen; D002278:Carcinoma in Situ / Q000139:chemically induced*; D002296:Carcinosarcoma / Q000139:chemically induced*; D004715:Endometriosis / Q000139:chemically induced*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D018200:Mixed Tumor, Mullerian / Q000139:chemically induced* / Q000473:pathology / Q000628:therapy; D011960:Receptors, Estrogen / Q000032:analysis; D013629:Tamoxifen / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed; D014594:Uterine Neoplasms / Q000139:chemically induced* / Q000473:pathology / Q000628:therapy
D018931:Antineoplastic Agents, Hormonal; D002272:Carcinoembryonic Antigen; D011960:Receptors, Estrogen; D013629:Tamoxifen