Simultaneous determination of dimethylarsinic acid and monomethylarsonic acid after derivatization with thioglycol methylate by gas chromatography/mass spectrometry.
A gas chromatography/mass spectrometry (GC/MS) method has been developed to determine two methylated arsenic species in human urine samples. The yield of derivatization for dimethylarsinic acid (DMA) and monomethylarsonic acid (MMA) using thioglycol methylate (TGM) was measured. The detection limit for the derivatized DMA and MMA using the GC/MS method are 0.95 and 0.8 ng cm-3, respectively. This simple and rapid method has good precision and accuracy. Fragmentation routes of derivatized MMA and DMA are suggested on accurate mass measurements.
Mester
Z
Z
Chemistry and Biochemistry Department of University of Horticulture and Food Industry, Budapest, Hungary.
Horváth
G
G
Vitányi
G
G
Lelik
L
L
Fodor
P
P
D001152:Arsenicals / Q000652:urine*; D002101:Cacodylic Acid / Q000652:urine*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007202:Indicators and Reagents; D008970:Molecular Weight; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013864:Thioglycolates
D001152:Arsenicals; D007202:Indicators and Reagents; D013864:Thioglycolates; D002101:Cacodylic Acid; C020300:monomethylarsonic acid; C037474:methyl thioglycolate