Biophysical and biochemical properties of oligodeoxy-nucleotides containing 4'-C- and 5'-C-substituted thymidines.
We have previously reported oligodeoxynucleotides (ODNs) containing 4'-C- and 5'-C-substituted thymidines, which demonstrated certain favorable biophysical and biochemical properties. In this communication, the hybridization and nuclease stability data of the ODNs along with their capability to induce RNase H activity are presented.
Wang
G
G
Research Department, ICN Pharmaceuticals, Inc., Costa Mesa, CA 92626, USA.
Middleton
P J
PJ
Lin
C
C
Pietrzkowski
Z
Z
D015703:Antigens, CD / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008956:Models, Chemical; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D018123:Receptors, Interleukin / Q000378:metabolism; D023062:Receptors, Interleukin-8A; D016914:Ribonuclease H / Q000378:metabolism; D013936:Thymidine / Q000737:chemistry*
D015703:Antigens, CD; D009841:Oligonucleotides; D018123:Receptors, Interleukin; D023062:Receptors, Interleukin-8A; D016914:Ribonuclease H; D013936:Thymidine