Assessment of flow mismatch with pharmacologic stress test on myocardial contrast echocardiography in a model of critical stenosis: adenosine triphosphate and dipyridamole.
Although adenosine triphosphate (ATP) is a favorable vasodilator because of its short-acting duration, the agent's effectiveness in facilitating the diagnosis of myocardial ischemia with myocardial contrast echocardiography (MCE) is not fully understood. The goal of this study was to examine the efficacy of intravenous ATP administration (0.15 to 0.30 mg/kg/min for 5 minutes) in diagnosing the flow mismatch with MCE. To achieve this, a critical stenosis was produced in the left circumflex artery in 10 anesthetized dogs. The peak intensity ratio of risk area to control area was reduced by ATP from 0.51 +/- 0.19 to 0.31 +/- 0.12 (P <.05). Systolic wall thickening of the risk area did not change significantly (32.8% +/- 9.8% to 27.5% +/- 12.8%). These changes did not differ from those obtained after dipyridamole. We conclude that MCE with intravenous ATP administration is as useful as the dipyridamole method for diagnosing critical coronary stenosis.
Shishido
T
T
Department of Cardiovascular Dynamics and the Cardiology Division of Medicine, Osaka University, Suita, Osaka, Japan.tosjoc@res.ncvc.go.jp
Beppu
S
S
Matsuda
H
H
Miyatake
K
K
D000255:Adenosine Triphosphate / Q000008:administration & dosage; D000418:Albumins; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003287:Contrast Media; D003326:Coronary Circulation / Q000187:drug effects*; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D003331:Coronary Vessels / Q000000981:diagnostic imaging* / Q000187:drug effects; D004176:Dipyridamole / Q000008:administration & dosage; D004195:Disease Models, Animal; D004285:Dogs; D004452:Echocardiography / Q000379:methods; D006339:Heart Rate / Q000187:drug effects; D007275:Injections, Intravenous; D015999:Multivariate Analysis; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging; D009206:Myocardium / Q000473:pathology; D014665:Vasodilator Agents / Q000008:administration & dosage
D000418:Albumins; D003287:Contrast Media; D014665:Vasodilator Agents; D004176:Dipyridamole; D000255:Adenosine Triphosphate