Effects of acute and chronic fluoxetine treatment of CRH-induced anxiety.
The effects of acute and chronic fluoxetine treatment on anxiogenic effect of corticotropin-releasing hormone (CRH) were studied in the social interaction test in male Sprague-Dawley rats. Injection of CRH (100 ng, i.c.v.), fluoxetine (5 mg/kg, i.p.) or their combination had significant anxiogenic effects (decrease in total interaction time and increase in self-grooming) in the social interaction test. The effects of CRH and fluoxetine in combination were not additive. Fluoxetine, but not CRH significantly inhibited locomotor activity. After chronic fluoxetine treatment (5 mg/kg/day, 21 days) the acute anxiogenic effects of either CRH or fluoxetine were abolished. Our studies provide evidence for a 5-HT/CRH interaction in the regulation of anxiety.
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Laboratory of Neurochemistry and Experimental Medicine, National Institute of Psychiatry and Neurology, Budapest, Hungary.
Anheuer
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Bagdy
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D000818:Animals; D001007:Anxiety / Q000139:chemically induced*; D001522:Behavior, Animal / Q000187:drug effects*; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology; D004338:Drug Combinations; D005473:Fluoxetine / Q000494:pharmacology*; D006120:Grooming / Q000187:drug effects; D007398:Interpersonal Relations; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012726:Sexual Behavior, Animal / Q000187:drug effects; D013997:Time Factors
D004338:Drug Combinations; D005473:Fluoxetine; D003346:Corticotropin-Releasing Hormone