ABL amplification in a patient with lymphoid blast crisis of chronic myelogenous leukaemia.
Although chronic phase myelogenous leukaemia (CML) is characterised by the Philadelphia (Ph) chromosome leading to a fusion of the BCR and ABL genes, additional genetic alterations involved in blast crisis are poorly understood. We report an at least 15-fold amplification of the ABL oncogene in a 29-year-old male patient with a variant Ph-positive t(19;22)(p13;q11.2) CML who presented in lymphoid blast crisis. Our finding suggests that an amplification of the ABL oncogene might play a part in the appearance of an aggressive phenotype in some cases of CML.
Kenner
L
L
Institute of Pathology, University of Graz, Austria.
Beham-Schmid
C
C
Kerbl
R
R
Schmidt
H H
HH
Sill
H
H
Hoefler
G
G
D000328:Adult; D001752:Blast Crisis / Q000473:pathology*; D015139:Blotting, Southern; D002908:Chronic Disease; D005784:Gene Amplification; D016313:Genes, abl / Q000235:genetics*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics* / Q000473:pathology*; D008214:Lymphocytes / Q000473:pathology*; D008297:Male