title: Commentary on the use of run-in periods in clinical trials.
abstract: Concerns have been raised about the applicability of clinicals trials to the so-called "real world" setting of clinical practice when such trials employ run-in periods. In fact, run-in periods are an essential part of good medical practice, and the limited practical applicability of clinical trial results relates more to their rigid artificial protocol setting.
authors: J A
authors: JA
authors: Franciosa
mesh_terms: D002317:Cardiovascular Agents / Q000008:administration & dosage; D006801:Humans; D018579:Patient Selection; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D012107:Research Design
chemical_list: D002317:Cardiovascular Agents