Use of a mixture of medium-chain triglycerides and longchain triglycerides versus long-chain triglycerides in critically ill surgical patients: a randomized prospective double-blind study.
Twenty critically-ill surgical patients who needed total parenteral nutrition were randomly enrolled in a double-blind study comparing two intravenous fat emulsions: one containing a mixture of 50% medium-chain triglycerides and 50% long-chain triglycerides and another containing 100% longchain triglycerides. The purpose of this study was to investigate metabolic and biochemical differences between both emulsions with special reference to liver enzymes. After a baseline period of 24 h with only glucose and NaCl infusion, the lipid emulsion was added continuously during 24 h over 5 days. The parenteral nutrition was administered in mixture bags containing amino-acids, glucose and lipids together. Two-thirds of the non-protein calories were administered as glucose 40% and one third as either long-chain triglycerides or a mixture of medium-chain triglycerides and long-chain triglycerides. The total amount of non-protein calories received was the measured energy expenditure during the baseline period plus 10% and was fixed during the study. Plasma substrate concentrations, energy expenditure, and nitrogen balance were determined and arterial blood samples were taken. No toxic effects or complications attributable to one of the two emulsions were observed. There was no significant difference in energy expenditure, nitrogen balance, liver function tests, carnitine, transferrin, pre-albumin, albumin, cholesterol, triglycerides and free fatty acids. The only parameter that showed a different pattern of reaction between the two emulsions was serum bilirubin concentration. In this study no evidence of any advantageous effect of a mixture of medium-chain triglycerides and long-chain triglycerides was seen.
Nijveldt
R J
RJ
Department of Surgery, Free University Hospital, Amsterdam, The Netherlands.
Tan
A M
AM
Prins
H A
HA
de Jong
D
D
van Rij
G L
GL
Wesdorp
R I
RI
van Leeuwen
P A
PA
D000328:Adult; D000368:Aged; D001663:Bilirubin / Q000097:blood; D002331:Carnitine / Q000097:blood; D016638:Critical Illness / Q000628:therapy*; D004311:Double-Blind Method; D002149:Energy Intake; D004734:Energy Metabolism; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage*; D005260:Female; D005947:Glucose / Q000008:administration & dosage; D006801:Humans; D006885:Hydroxybutyrates / Q000097:blood; D008297:Male; D008875:Middle Aged; D010289:Parenteral Nutrition, Total; D011446:Prospective Studies; D014280:Triglycerides / Q000008:administration & dosage* / Q000097:blood / Q000737:chemistry
D005217:Fat Emulsions, Intravenous; D006885:Hydroxybutyrates; D014280:Triglycerides; D005947:Glucose; D001663:Bilirubin; D002331:Carnitine