Primary intracerebral Hodgkin's disease: report of a case with Epstein-Barr virus association and review of the literature.
A case of primary intracerebral Hodgkin's disease (HD) without dural attachment in a 54-year-old immunocompetent patient is described. The infiltrate was located superficially in the occipital lobe and corresponded to the histologic type of nodular sclerosis. A typical immunohistochemical profile (membrane and cytoplasmic staining with dotlike Golgi enhancement of CD30, moderate cytoplasmic staining of CD15 in the Golgi area, membrane staining of CD20 of <10% of blastic cells, CD45RB negative) and in addition Epstein-Barr virus (EBV) latent membrane protein was detectable in Reed-Sternberg cells. Staging revealed no other organ sites of involvement. After combined surgery, postoperative radiotherapy, and chemotherapy, there are no signs of recurrence or systemic disease on follow-up for >1 year. To the authors' best knowledge, an association of EBV with primary central nervous system HD has not been demonstrated before.
Klein
R
R
Institute of Pathology, Division Neuropathology, University of Würzburg, Germany.
Müllges
W
W
Bendszus
M
M
Woydt
M
M
Kreipe
H
H
Roggendorf
W
W
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000473:pathology* / Q000628:therapy / Q000821:virology; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D006566:Herpesviridae Infections / Q000473:pathology* / Q000821:virology; D004854:Herpesvirus 4, Human / Q000302:isolation & purification / Q000472:pathogenicity*; D006689:Hodgkin Disease / Q000473:pathology* / Q000628:therapy / Q000821:virology; D006801:Humans; D007124:Immunoenzyme Techniques; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D011344:Procarbazine / Q000627:therapeutic use; D016896:Treatment Outcome; D014412:Tumor Virus Infections / Q000473:pathology* / Q000821:virology; D014750:Vincristine / Q000627:therapeutic use
D014408:Biomarkers, Tumor; D011344:Procarbazine; D014750:Vincristine; D003520:Cyclophosphamide; D011241:Prednisone