title: Transmyocardial laser revascularization: a qualitative systematic review.
abstract: OBJECTIVE
  To evaluate the status of transmyocardial laser revascularization (TMLR) from an evidence-based perspective to help hospitals make resource management decisions.
  
  
  METHODS
  Qualitative systematic review of the clinical literature.
  
  
  METHODS
  We searched the reference databases MEDLINE, BIOSIS, EMBASE, SciSearch, and Current Contents to identify all articles related to TMLR published between January 1985 and March 1997. We collected, analyzed, and summarized clinical studies in evidence tables.
  
  
  RESULTS
  The cumulative evidence available in the medical literature regarding the safety and effectiveness of TMLR encompasses approximately 2000 patients treated worldwide, primarily those with medically refractory angina. Preliminary data suggest that TMLR has an acceptable survival rate and effectively relieves angina in approximately 75% of patients. Data showing improved myocardial perfusion, cardiac function, or prognosis are inconclusive. The mechanism by which TMLR relieves angina is not yet known.
  
  
  CONCLUSIONS
  Early evidence regarding TMLR suggests it will be useful for treating patients with end-stage coronary artery disease. Definitive recommendations await critical analysis of the results of ongoing randomized clinical trials, post-market surveillance studies, and third-party payer acceptance.
authors: Clinical Practice Advancement Center, University HealthSystem Consortium, Oak Brook, IL 60523, USA.
authors: J P
authors: JP
authors: Cummings
authors: T A
authors: TA
authors: Ratko
authors: K A
authors: KA
authors: Matuszewski
mesh_terms: D006801:Humans; D014487:Centers for Medicare and Medicaid Services, U.S.; D003327:Coronary Disease / Q000601:surgery; D003625:Data Collection; D003659:Decision Making, Organizational; D019317:Evidence-Based Medicine; D015276:Health Care Rationing; D007349:Insurance, Health, Reimbursement; D053685:Laser Therapy / Q000009:adverse effects / Q000191:economics / Q000379:methods; D009204:Myocardial Revascularization / Q000009:adverse effects / Q000191:economics / Q000379:methods; D013503:Surgery Department, Hospital / Q000458:organization & administration; D013673:Technology Assessment, Biomedical; D016896:Treatment Outcome; D014481:United States; D014486:United States Food and Drug Administration