title: Strain distribution of mice in discriminated Y-maze avoidance learning: genetic and procedural differences.
abstract: The current study was conducted to characterize discriminated avoidance learning in mice by using a Y-maze task. In Experiment 1, the task parameters were manipulated, including the amount of time spent in the start arm, the amount of time to make the avoidance response, and the intertrial interval (ITI) using C57 x SJL F1 hybrid mice. Avoidance performance was significantly improved with longer times to avoid the shock and longer ITIs. In Experiment 2, mice from 4 inbred strains (BALB/cByJ, DBA/2J, C57BL/6J, and SJL/J), an F1 hybrid (C57 x SJL), and 1 outbred strain (CD1) were tested with various ITIs. Strain differences were observed in avoidance learning, with BALB, DBA, C57 x SJL and CD1 mice showing significantly better avoidance learning than C57 mice, which were better than SJL mice. These data demonstrate that Y-maze performance is significantly influenced by the genetic background of the mouse and the parameters of the task.
authors: Department of Neuropharmacology, The Scripps Research Institute, USA. C_Heyser@acad.fandm.edu
authors: C J
authors: CJ
authors: Heyser
authors: J S
authors: JS
authors: McDonald
authors: I Y
authors: IY
authors: Polis
authors: L H
authors: LH
authors: Gold
mesh_terms: D000818:Animals; D001143:Arousal / Q000235:genetics; D001362:Avoidance Learning / Q000502:physiology*; D004597:Electroshock; D004924:Escape Reaction / Q000502:physiology; D005239:Fear / Q000502:physiology*; D005838:Genotype; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D051379:Mice; D008815:Mice, Inbred Strains; D011930:Reaction Time / Q000235:genetics*; D013045:Species Specificity