Neuronal guidance. A genetic perspective.
Remarkable advances have been made recently to identify the molecules required for the development of neural connections within the brain. A range of ligands and receptors have been uncovered that guide extending neurons to appropriate targets and away from inappropriate areas. These molecules point to the signalling mechanisms that guide the neurons and provide entry points for the further dissection of this process. Here I highlight the part genetic screens and analyses have played in revealing some of the key players in neuronal guidance.
Tear
G
G
Department of Biochemistry, Imperial College, London, UK. guy.tear@kcl.ac.uk
D001369:Axons; D018507:Gene Expression Regulation, Developmental; D009474:Neurons / Q000166:cytology*