title: [Chemical modification of allergen leading to changes in its epitopic activity].
abstract: Modification of a model allergen ovalbumin (OA) with succinylation led to a decrease of its allergenicity measured by passive cutaneous anaphylaxis reaction, RAST inhibition assay and basophil histamine release. Modified OA stimulated OA-specific T-cell hybrid 3DO-548 to produce IL-2 at the same level as in case of non-modified OA. Modified OA did not induce anti-OA IgE, but did induce anti-OA IgG antibodies. This approach to chemical modification of allergen-selective blockade of B-cell epitopes while not affecting T-cell epitopes suggests new opportunities in creation of safe and effective allergovaccines.
authors: A A
authors: AA
authors: Babakhin
authors: I S
authors: IS
authors: Gushchin
authors: S M
authors: SM
authors: Andreev
authors: A I
authors: AI
authors: Petrukhina
authors: A V
authors: AV
authors: Viler
authors: B
authors: B
authors: Stokinger
authors: G
authors: G
authors: Nolte
authors: L M
authors: LM
authors: Dubuske
authors: R M
authors: RM
authors: Khaitov
authors: R V
authors: RV
authors: Petrpv
mesh_terms: D000485:Allergens / Q000187:drug effects* / Q000276:immunology; D000818:Animals; D000939:Epitopes / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013268:Stimulation, Chemical
chemical_list: D000485:Allergens; D000939:Epitopes