title: Long-term effects on the regulation of pancreatic secretion after gastric surgery.
abstract: BACKGROUND
  Apart from smoking, known risk factors for the development of pancreatic carcinoma are few, gastric resection being proposed as one. The trophic effect of cholecystokinin (CCK) on the pancreatic gland is well known from animal experience and increased concentrations of CCK in plasma have been shown to induce pancreatic neoplasia experimentally. In several studies the release of CCK in response to food ingestion has been shown to be increased following gastric surgery. However, in those studies, the time between surgery and investigation of the CCK response was short, and methods of CCK analysis have since improved.
  
  
  METHODS
  In patients, partially gastrectomized 8 years (median) earlier, we studied the plasma concentrations of CCK, insulin and gastrin, as well as some specific pancreatic enzymes. The findings were compared to an age-matched control group of individuals not subjected to gastric surgery.
  
  
  RESULTS
  Basal CCK concentrations in the operated group were found to be lower, but increased postprandially to the same level as in controls. Serum levels of specific pancreatic enzymes were equal in the 2 groups.
  
  
  CONCLUSIONS
  It is possible that a disturbed regulation of pancreatic secretion, or a secretory dysfunction within the gland, following partial gastrectomy, could contribute to the development of pancreatic carcinoma. However, our findings do not favor the idea of plasma CCK as a promotor of pancreatic carcinoma.
authors: Department of Surgery and Surgical Pathophysiology, Lund University, University Hospital MAS (UMAS), Malmö, Sweden.
authors: M
authors: M
authors: Hedberg
authors: L
authors: L
authors: Janzon
authors: J F
authors: JF
authors: Rehfeld
authors: A
authors: A
authors: Borgström
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002766:Cholecystokinin / Q000096:biosynthesis* / Q000097:blood; D015331:Cohort Studies; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects; D005755:Gastrins / Q000096:biosynthesis* / Q000097:blood; D006801:Humans; D007328:Insulin / Q000096:biosynthesis* / Q000097:blood; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000201:enzymology* / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000209:etiology; D011184:Postoperative Period; D011863:Radioimmunoassay; D012016:Reference Values; D012680:Sensitivity and Specificity
chemical_list: D005755:Gastrins; D007328:Insulin; D002766:Cholecystokinin