title: Regional cerebral blood flow during script-driven imagery in childhood sexual abuse-related PTSD: A PET investigation.
abstract: OBJECTIVE
  The purpose of this study was to determine whether anterior limbic and paralimbic regions of the brain are differentially activated during the recollection and imagery of traumatic events in trauma-exposed individuals with and without posttraumatic stress disorder (PTSD).
  
  
  METHODS
  Positron emission tomography (PET) was used to measure normalized regional cerebral blood flow (CBF) in 16 women with histories of childhood sexual abuse: eight with current PTSD and eight without current PTSD. In separate script-driven imagery conditions, participants recalled and imagined traumatic and neutral autobiographical events. Psychophysiologic responses and subjective ratings of emotional state were measured for each condition.
  
  
  RESULTS
  In the traumatic condition versus the neutral control conditions, both groups exhibited regional CBF increases in orbitofrontal cortex and anterior temporal poles; however, these increases were greater in the PTSD group than in the comparison group. The comparison group exhibited regional CBF increases in insular cortex and anterior cingulate gyrus; increases in anterior cingulate gyrus were greater in the comparison group than in the PTSD group. Regional CBF decreases in bilateral anterior frontal regions were greater in the PTSD group than in the comparison group, and only the PTSD group exhibited regional CBF decreases in left inferior frontal gyrus.
  
  
  CONCLUSIONS
  The recollection and imagery of traumatic events versus neutral events was accompanied by regional CBF increases in anterior paralimbic regions of the brain in trauma-exposed individuals with and without PTSD. However, the PTSD group had greater increases in orbitofrontal cortex and anterior temporal pole, whereas the comparison group had greater increases in anterior cingulate gyrus.
authors: Department of Psychiatry, Massachusetts General Hospital, Boston, USA. Ishin01@emerald.tufts.edu
authors: L M
authors: LM
authors: Shin
authors: R J
authors: RJ
authors: McNally
authors: S M
authors: SM
authors: Kosslyn
authors: W L
authors: WL
authors: Thompson
authors: S L
authors: SL
authors: Rauch
authors: N M
authors: NM
authors: Alpert
authors: L J
authors: LJ
authors: Metzger
authors: N B
authors: NB
authors: Lasko
authors: S P
authors: SP
authors: Orr
authors: R K
authors: RK
authors: Pitman
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging; D002245:Carbon Dioxide; D002648:Child; D002650:Child Abuse, Sexual / Q000523:psychology / Q000706:statistics & numerical data*; D015897:Comorbidity; D005260:Female; D006801:Humans; D007092:Imagination / Q000502:physiology; D008032:Limbic System / Q000098:blood supply / Q000000981:diagnostic imaging; D008875:Middle Aged; D010104:Oxygen Radioisotopes; D012039:Regional Blood Flow; D013313:Stress Disorders, Post-Traumatic / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000523:psychology; D014055:Tomography, Emission-Computed; D014705:Verbal Behavior / Q000502:physiology
chemical_list: D010104:Oxygen Radioisotopes; D002245:Carbon Dioxide