Membrane proteins: A tale of barrels and corks.
Crystal structures have been solved for two bacterial outer membrane proteins, FhuA and FepA, which mediate active transport of chelated iron. Analysis of ligand-induced changes in the structure of FhuA has provided our first structural insights into an active transport mechanism for a complex solute.
Sansom
M S
MS
Laboratory of Molecular Biophysics, Department of Biochemistry, The University of Oxford, The Rex Richards Building, South Parks Road, Oxford, OX1 3QU, UK. mark@biop.ox.ac.uk
D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry* / Q000378:metabolism; D001692:Biological Transport; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism; D018360:Crystallography, X-Ray; D004926:Escherichia coli / Q000737:chemistry* / Q000378:metabolism; D029968:Escherichia coli Proteins; D011956:Receptors, Cell Surface; D011991:Receptors, Virus / Q000737:chemistry / Q000378:metabolism
D001425:Bacterial Outer Membrane Proteins; D002352:Carrier Proteins; D029968:Escherichia coli Proteins; C050900:FhuA protein, E coli; D011956:Receptors, Cell Surface; D011991:Receptors, Virus; C029489:enterobactin receptor