Annexins.
The annexins are a family of proteins that bind anionic phospholipid surfaces in a Ca(2+)-dependent manner (general reviews include Raynal & Pollard 1994, Swairjo & Seaton 1994, Seaton 1996, Mollenhauer, 1997). Due to this functional property, individual annexins have been discovered independently by numerous laboratories with diverse experimental goals. Ca2+ characteristically causes the annexins to shift from a soluble to membrane associated state. This shift is believed to be the mechanism that underlies annexin cellular function.
Seaton
B A
BA
Department of Physiology, Boston University School of Medicine, MA 02118, USA.
Dedman
J R
JR
D000818:Animals; D017302:Annexins / Q000737:chemistry* / Q000378:metabolism*; D001665:Binding Sites; D002118:Calcium / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D017433:Protein Structure, Secondary
D017302:Annexins; D002118:Calcium