title: Management of patients with acute myocardial infarction at five academic medical centers: clinical characteristics, resource utilization, and outcome.
abstract: BACKGROUND
  Although variability in management of cardiovascular syndromes has been demonstrated among regions, the extent to which variability exists among academic medical centers in different countries in uncertain.
  
  
  METHODS
  This retrospective cohort study includes data on consecutive patients (n = 694) with acute myocardial infarction who were admitted to five teaching hospitals from different countries (84, Brigham and Women's Hospital, USA; 97, Iizuka Hospital, Japan; 64, Hospital de Clinicas de Porto Alegre, Brazil; 62, Universitätsklinikum Charité, Germany; and 387, Hôpital Cantonal Universitaire de Genève, Switzerland) during a one-year period. Data were collected via chart review on clinical characteristics, rates of diagnostic and therapeutic interventions, complications and mortality, length of stay, and one-year follow-up outcomes.
  
  
  RESULTS
  Patients' clinical characteristics varied among these institutions, with the lowest prevalence of antero-septal myocardial infarction at the US hospital. The US hospital had the lowest rate of use of thrombolytic therapy and did not have the highest rate for any invasive procedure. Average length of stay ranged from 7.7 +/- 4.3 days in the US hospital to 47.2 +/- 27.9 days in the Japanese hospital. There were no differences in one-year mortality among the four institutions (4% to 8%, P = 0.881) for which data were available.
  
  
  CONCLUSIONS
  In this nonrandom sample of academic medical centers, the use of aggressive therapies for acute myocardial infarction was at least as common at non-US as US hospitals. Length of stay was much shorter at the US hospital. Despite these variations in management, evidence for differences in outcomes at one year were not detected.
authors: Aso HealthCare Institute, Japan.
authors: K
authors: K
authors: Matsui
authors: C A
authors: CA
authors: Polanczyk
authors: J M
authors: JM
authors: Gaspoz
authors: H
authors: H
authors: Theres
authors: F X
authors: FX
authors: Kleber
authors: A
authors: A
authors: Sobashima
authors: S
authors: S
authors: Okamatsu
authors: J M
authors: JM
authors: Viana
authors: J P
authors: JP
authors: Ribeiro
authors: S
authors: S
authors: Emonet
authors: T H
authors: TH
authors: Lee
mesh_terms: D000046:Academic Medical Centers / Q000191:economics; D000368:Aged; D015331:Cohort Studies; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006295:Health Resources / Q000706:statistics & numerical data*; D006801:Humans; D007527:Isoenzymes; D007902:Length of Stay / Q000191:economics; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000201:enzymology / Q000401:mortality / Q000628:therapy*; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D007527:Isoenzymes; D003402:Creatine Kinase