Anti-inflammatory doses of ibuprofen: effect on neutrophils and exercise-induced muscle injury.
The purpose of the study was to determine the effect of anti-inflammatory doses of ibuprofen on neutrophils, neutrophil O2* production, and markers of muscle injury. Males (n=10) performed 2 bouts of one-arm eccentric exercise on opposite arms separated by three weeks. Subjects received 2400 mg x d(-1) of ibuprofen or a placebo 5 d before exercise and during 10 d of recovery. Measurements were made before the treatments, pre-exercise, at 4 h, and at 1, 2, 3, 4 and 10 d post-exercise. Circulating neutrophil counts were similar between the treatments at the sampling points. Neutrophil counts were higher (p<0.05) for ibuprofen and were elevated (p<0.05) at 4h post-exercise relative to pre-exercise in both treatments. Stimulated neutrophil O2* production was lower for ibuprofen relative to placebo at pre-exercise and was increased (p<0.05) at 4 h and 4 d of both treatments. CK activity at 3 d post-exercise was lower (p<0.05) for ibuprofen relative to placebo. Isometric strength, soreness, tenderness, and arm angles were similar between the treatments. In conclusion, anti-inflammatory doses of ibuprofen reduced CK activity but not the neutrophil response or other indirect markers of muscle injury during recovery from eccentric arm exercise.
Pizza
F X
FX
Texas Christian University, Exercise Physiology Laboratory, Fort Worth, Texas, USA. FPizza@pop3.utoledo.edu
Cavender
D
D
Stockard
A
A
Baylies
H
H
Beighle
A
A
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D015444:Exercise; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage*; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects / Q000473:pathology*; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007052:Ibuprofen